AgingHallmarkDB


Deregulated Nutrient Sensing

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Matched Disease Name Matched Aging Hallmark Sentence PMID
Increased insulin level, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance and hyperinsulinemia are often found in first-degree relatives of non-insulin-dependent diabetes mellitus (NIDDM) patients, and are currently considered a familial trait of this population at increased risk for diabetes.7476284
Diabetes MellitusDeregulated Nutrient SensingIn this population, the current view of insulin resistance in "early" diabetes was supported by insulin-specific measurements.7476300
Glucose Intolerance (disease)Deregulated Nutrient SensingAging is associated with an increased accumulation of abdominal fat, glucose intolerance, and insulin resistance.7476341
Polycystic Ovary Syndrome, HyperandrogenismDeregulated Nutrient SensingHormonally regulated serine phosphorylation of human P450c17 suggests a possible mechanism for human adrenarche and may be a unifying etiologic link between the hyperandrogenism and insulin resistance that characterize the polycystic ovary syndrome.7479852
Eyelid Xanthoma, DyslipidemiasDeregulated Nutrient SensingTo know the prevalence and types of dyslipidemia associated with xanthelasma.7485205
Eyelid Xanthoma, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe findings support the notion that xanthelasma is a marker of dyslipidemia, and underline the need to determine a full lipid profile in these patients to detect those potentially at increased risk of cardiovascular disease.7485205
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe relation between the C-peptide concentration in twenty-four-hour urine specimens and atherogenic risk factors was investigated in 38 patients with noninsulin-dependent diabetes mellitus in an attempt to determine the significance of urine C-peptide in diagnosing "syndrome X," which is characterized by insulin resistance.7486212
ObesityDeregulated Nutrient SensingThe beta 3AR may be one of the loci contributing to obesity and hyperinsulinemia/insulin resistance in Japanese subjects.7487991
Hyperinsulinism, NEUROD1 wt AlleleDeregulated Nutrient SensingAlthough insulin sensitivity was not measured, fasting hyperinsulinaemia in NSY mice suggests that insulin resistance may also contribute to the pathogenesis of NIDDM.7489831
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAccording to data on the accumulation of atherogenic risks (hypertension, dyslipidaemia, and smoking), IMT increased linearly in non-IGT and IGT subjects.7489842
Hyperinsulinism, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance and hyperinsulinaemia in mild to moderate progressive chronic renal failure and its association with aerobic work capacity.7489839
Glucose Intolerance (disease), Overweight, ObesityDeregulated Nutrient SensingThe prevalence of overweight or obesity increased, and the rates of glucose intolerance changed little.7496233
Diabetes Mellitus, metabolic disturbance, ObesityDeregulated Nutrient SensingThe risk of diabetes increased with the increased central obesity and metabolic disturbances associated with insulin resistance.7497867
Hypertensive (finding)Deregulated Nutrient SensingIn conclusion, our results indicate that in nonobese hypertensive patients, insulin resistance does not have any influence on the 24-hour blood pressure profile or on left ventricular mass index.7498973
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingHigh intracellular calcium can cause insulin resistance, as seen in non-insulin-dependent diabetes mellitus (NIDDM) patients.7518543
NEUROD1 wt AlleleDeregulated Nutrient SensingOur data indicate that elevated PHF may be responsible for insulin resistance in a fraction of NIDDM patients and suggest that PHF may be related to serum cholesterol levels in NIDDM.7518543
Renal Insufficiency, Glucose Intolerance (disease)Deregulated Nutrient SensingRenal dysfunction and glucose intolerance appeared when the blood level of FK506 was high.7526689
Glucose Intolerance (disease), NeoplasmsDeregulated Nutrient SensingCurative resection ameliorates glucose intolerance, while tumor persistence can enhance serum glucose levels.7532931
Angiosarcoma of liver, Insulin-resistant diabetes mellitusDeregulated Nutrient Sensing[Coincidence of hepatic angiosarcoma and insulin-resistance diabetes mellitus with high-dose intraperitoneal insulin therapy].7534000
diabeticDeregulated Nutrient SensingIn six type 2 diabetic subjects and a subject with type A insulin resistance, islet amyloid deposits were reactive to anti-IAPP8-17 antibody, but not to anti-N-terminal and C-terminal flanking peptide antibodies.7535678
Increased insulin level, Dyslipidemias, Non-insulin Hypoglycemic, Diabetes MellitusDeregulated Nutrient Sensing[Dyslipidemia and hyperinsulinemia in normoglycemic-obese relatives of patients with non-insulin dependent diabetes mellitus].7548306
Coronary heart diseaseDeregulated Nutrient SensingBoth the insulin resistance syndrome and phenotype B have also been related to increased risk of coronary heart disease.7550534
Increased insulin level, Cardiovascular DiseasesDeregulated Nutrient SensingHyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance.7554195
Increased insulin level, Hypertrophic CardiomyopathyDeregulated Nutrient SensingInsulin resistance, hyperinsulinemia, and myocardial hypertrophy frequently coexist in patients.7554195
Hypothalamic Dysfunction Syndromes, Hypogonadotropic hypogonadismDeregulated Nutrient SensingIsolated combined growth hormone and gonadotrophin deficiency due to hypothalamic dysfunction, associated with insulin resistance.7554320
Hyperlipidemia, Hypogonadotropic hypogonadismDeregulated Nutrient SensingThe presence of congenital combined growth hormone and gonadotrophin deficiency on the basis of a suprapituitary defect suggests the existence of common or related pathways regulating GnRH and GHRH synthesis or secretion and may have contributed to the ultimate development of insulin resistance and hyperlipidaemia.7554320
Dyslipoproteinemias, Glucose Intolerance (disease)Deregulated Nutrient SensingJapanese men with glucose intolerance frequently have small LDL, and this abnormality is associated with other dyslipoproteinemias and increased waist-to-hip ratio.7555476
NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance is associated with high plasma ouabain-like immunoreactivity concentration in NIDDM.7556980
Hypertensive (finding), NEUROD1 wt AlleleDeregulated Nutrient SensingSix of 57 NIDDM patients studied exhibited very high (> 1500 pmol/l) plasma OLI concentrations, showed marked insulin resistance and were all hypertensive.7556980
Hypertension, CTCAEDeregulated Nutrient SensingThese results indicate that hypertension is independently associated with glucose tolerance and insulin resistance in three Caucasian cohorts.7556987
Hypertensive (finding)Deregulated Nutrient Sensing[Blood insulin in fasting conditions as a simple marker of insulin resistance in hypertensive patients].7569442
Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is associated to hypertension, obesity and diabetes and may be an independent cardiovascular risk factor.7569442
Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore pharmacological interventions should aim to improve insulin sensitivity.7575750
Diabetes MellitusDeregulated Nutrient SensingBoth groups were comparable in age, body-mass index and duration of diabetes and had a similar degree of insulin resistance at baseline.7575750
NEUROD1 wt AlleleDeregulated Nutrient SensingLinkage analysis of 19 candidate regions for insulin resistance in familial NIDDM.7589821
HyperlipidemiaDeregulated Nutrient SensingHowever, patients with antibodies against endothelial cell and/or cardiolipin had a lower prevalence of hyperlipidaemia/dyslipidaemia when compared to patients without these antibodies (P < 0.05).7595183
Hyperlipidemia, Blood VesselDeregulated Nutrient SensingThe lower occurrence of hyperlipidaemia/dyslipidaemia in patients with autoantibodies, in comparison to patients without the antibodies, suggests that these antibodies have a role in vascular damage.7595183
Werner SyndromeDeregulated Nutrient SensingThese results demonstrate that insulin resistance in the patient with Werner's syndrome is caused by a defect that cannot be detected by means employed in this study, and suggest that the defect is present at the steps distal to the autophosphorylation of tyrosine kinase of insulin receptors.7599691
diabeticDeregulated Nutrient SensingAn association between insulin resistance and blood pressure levels has been found both in non-diabetic subjects and in type 2 diabetic patients.7599758
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingPrevalence and correction of hypothyroidism in a large cohort of patients referred for dyslipidemia.7605150
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingAll patients referred for diagnosis and treatment of dyslipidemia should be screened for hypothyroidism by measurement of thyrotropin values.7605150
Obesity, Abdominal, NEUROD1 wt AlleleDeregulated Nutrient SensingThe Trp64Arg allele of the beta 3-adrenergic receptor is associated with abdominal obesity and resistance to insulin and may contribute to the early onset of NIDDM:7609751
DyslipidemiasDeregulated Nutrient SensingIn type IV dyslipidaemia LDL-C may increase moderately.7612280
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingSeveral risk factors for the development of microalbuminuria such as: blood glucose unbalance, high blood pressure, dyslipidemia, genetic susceptibility have been described and discussed.7613502
ObesityDeregulated Nutrient SensingRecent studies have shown that central obesity (increased waist to hip ratio [WHR]) is related to insulin resistance and aging.7616857
Sleep Apnea, Obstructive, Hypertension, CTCAEDeregulated Nutrient Sensing[Glucose tolerance, insulin resistance and arterial hypertension in patients with obstructive sleep apnea syndrome].7617595
Sleep Apnea, Obstructive, Overweight, Hypertension, CTCAEDeregulated Nutrient SensingThe reduced glucose tolerance and increased insulin resistance in combination with arterial hypertension in this patient group is indicative that a combination of adiposity and OSAS represents a particularly high risk factor for the development of arterial hypertension even though the pathological mechanism responsible for the development of arterial hypertension is also present in members of both the normal weight OSAS group and the overweight group without OSAS who exhibit a metabolic predisposition for the development of hypertension.7617595
ObesityDeregulated Nutrient SensingInsulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.7623569
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient Sensing[Increase of gamma-glutamyltranspeptidase in patients with compensated hypoalphalipoproteinemia and type IIa dyslipidemias].7627821
Coronary heart diseaseDeregulated Nutrient SensingUric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome.7631632
AtherosclerosisDeregulated Nutrient SensingThe data suggest that serum uric acid may be involved in the obesity-insulin resistance syndrome, which in turn may explain the relation of serum uric acid to coronary atherosclerosis.7631632
Glucose Intolerance (disease), Cardiac ArrhythmiaDeregulated Nutrient SensingGlucose intolerance, cardiac arrhythmia, and estrogen replacement therapy were not significant predictors.7631731
Polycystic Ovary SyndromeDeregulated Nutrient SensingThere has been much debate concerning the relative contribution of insulin resistance to the development of polycystic ovaries (PCO).7634500
Hyperinsulinism, diabeticDeregulated Nutrient SensingThis suggests that body mass is a more important determinant of BMD than hyperinsulinaemia or insulin resistance in diabetic women.7638560
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDue to the fact that similar data were obtained for type II diabetic patients, an unknown relation to insulin resistance might be the underlying cause and should be further investigated.7645365
Glucose Intolerance (disease), Demographics DomainDeregulated Nutrient SensingFurthermore the potential for DM to increase with age, as has been suggested before, has been evaluated using the IGT as a proportion of total glucose intolerance (IGT/TGI) for the same parts of the tested sample.7648801
Diabetes MellitusDeregulated Nutrient SensingWe conclude, that physiologically elevated levels of FFa could potentially be responsible for a large part of the peripheral insulin resistance in patients with non-insulin-dependent diabetes mellitus.7657800
Hypertension, CTCAE, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance that exists in patients with essential hypertension and in those with non-insulin-dependent diabetes mellitus (NIDDM) may be the common denominator for the impaired glucose homeostasis and elevated blood pressure (BP) levels in patients with NIDDM.7662219
Weight decreased, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn spite of the potential benefits of reversal of insulin resistance and weight reduction, altering therapy of type II diabetes mellitus from insulin to tolazamide may increase blood pressure, thereby increasing cardiovascular risk.7662230
Laryngoonychocutaneous syndromeDeregulated Nutrient SensingInsulin resistance syndrome in postmenopausal women with cardiological syndrome X.7662453
Congenital AbnormalityDeregulated Nutrient SensingWomen with syndrome X tend to be insulin resistant and have lipid and lipoprotein abnormalities, but do not exhibit all characteristics of the insulin resistance syndrome.7662453
Acanthosis Nigricans, Polycystic Ovary SyndromeDeregulated Nutrient SensingAssociation of acanthosis nigricans with insulin resistance in patients with polycystic ovary syndrome.7662572
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingThis study was designed to explore the association of insulin resistance and acanthosis nigricans (AN) in patients with polycystic ovary syndrome (PCOS).7662572
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThese findings support the view that obese PCOS patients with AN do not have significantly higher insulin resistance than obese patients without AN.7662572
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingInsulin resistance is a necessary, but not the only, factor leading to the development of AN in patients with PCOS.7662572
MicroalbuminuriaDeregulated Nutrient SensingLongitudinal study of associations of microalbuminuria with the insulin resistance syndrome and sodium-lithium countertransport in nondiabetic subjects.7670946
Microalbuminuria, Myocardial Ischemia, diabeticDeregulated Nutrient SensingMicroalbuminuria in diabetic patients is associated with ischemic heart disease and insulin resistance.7670946
Chronic Obstructive Airway Disease, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAssociated diseases were: hypertension (45%), diabetes (40%), dyslipidemia (29%), chronic obstructive lung disease (6%).7671273
Peripheral arterial occlusive diseaseDeregulated Nutrient Sensing[Incidence of insulin resistance in peripheral arterial occlusive disease patients.7672743
ObesityDeregulated Nutrient SensingEpidemiologic study of central obesity, insulin resistance and associated disturbances in the urban population of North India.7676761
Coronary Artery Disease, ObesityDeregulated Nutrient SensingCentral obesity in association with insulin resistance is a strong predictor of coronary artery disease (CAD) in South Asians; however the prevalence of central obesity and insulin resistance in Indians are unknown.7676761
ObesityDeregulated Nutrient SensingThese findings indicate the existence of a modest degree of insulin resistance with a modest tendency to central obesity in the urban population of North India.7676761
Glucose Intolerance (disease), Hypertension, CTCAE, Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of glucose intolerance, diabetes mellitus, hypertension, hypertriglyceridemia and CAD were significantly higher in the higher quintiles of WHR above 0.88 compared to lower quintiles.7676761
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance may play a role in the pathogenesis of essential hypertension.7677082
Hyperlipidemia, Glucose Intolerance (disease), Hypertension, CTCAE, AtherosclerosisDeregulated Nutrient SensingExcess free fatty acid may cause the enhancement of lipid synthesis and gluconeogenesis as well as insulin resistance, resulting in hyperlipidemia, glucose intolerance, and hypertension and finally atherosclerosis.7695182
Dyslipidemias, Diabetes Mellitus, Heart failure, Simultaneous, ObesityDeregulated Nutrient SensingThe percentage of patients with concomitant diseases (dyslipidemia, diabetes, obesity, cardiac failure) is very high.7709040
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingUndiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project.7712700
Diabetes MellitusDeregulated Nutrient SensingTransient neonatal diabetes and later onset diabetes: a case of inherited insulin resistance.7717741
Diabetes MellitusDeregulated Nutrient SensingBoth her mother and sister had profound insulin resistance; neither had clinical diabetes.7717741
Diabetes MellitusDeregulated Nutrient SensingThis is the first time inherited insulin resistance has been implicated in the pathogenesis of permanent diabetes developing after transient neonatal diabetes.7717741
Hypercholesterolemia, Dyslipidemias, HyperlipidemiaDeregulated Nutrient SensingMetabolism of low density lipoproteins in nephrotic dyslipidemia: comparison of hypercholesterolemia alone and combined hyperlipidemia.7723244
Nephrons, Dyslipidemias, HyperlipidemiaDeregulated Nutrient SensingAnother pattern of dyslipidemia in nephrotic patients is an elevation of both cholesterol and triglyceride levels (combined hyperlipidemia).7723244
DyslipidemiasDeregulated Nutrient SensingIt has been postulated that the underlying cause of nephrotic dyslipidemia is an hepatic overproduction of apolipoprotein B (apo B)-containing lipoproteins.7723244
DyslipidemiasDeregulated Nutrient SensingThese data indicate that the metabolism of LDL is strikingly different between the two forms of nephrotic dyslipidemia.7723244
Cardiac complication, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingIn addition to the typical dyslipidaemia found in CAPD patients, high levels of Lp(a) and specific isoform patterns may in turn contribute to the elevated risk of coronary artery disease and other cardiovascular complications.7724034
Non-insulin HypoglycemicDeregulated Nutrient Sensing[Insulin resistance and combined therapy with sulfonylurea and insulin in non-insulin dependent diabetics].7725640
Diabetes MellitusDeregulated Nutrient SensingResults suggest that body mass index, physical inactivity, glucose level, and parental diabetes appear to be independent risk factors for diabetes, while triglyceride and systolic blood pressure levels may be markers for an adverse cardiovascular risk factor profile associated with diabetes and may reflect an insulin resistance syndrome.7728283
Glucose Intolerance (disease), Traumatic injuryDeregulated Nutrient SensingThese findings have implications for care: the elderly trauma patient will be weaker than a younger counterpart, and nutrition will need to be provided early, with the glucose intolerance of elderly people borne in mind.7728694
Hyperlipidemia, Microvascular AnginaDeregulated Nutrient Sensing[The significance of insulin resistance and hyperlipidemia in microvascular angina (syndrome X)].7732710
HyperlipoproteinemiasDeregulated Nutrient SensingThese findings suggest a pathogenetic role of insulin resistance, hyperlipoproteinemia and elevated levels of fibrinogen for impaired myocardial coronary reserve.7732710
Werner SyndromeDeregulated Nutrient SensingThese results suggest that the patients with Werner's syndrome express normal insulin receptors and that the primary genetic lesion for insulin resistance is not in the insulin receptor gene.7736897
Werner SyndromeDeregulated Nutrient SensingInsulin resistance in Werner's syndrome is thus likely by a post-receptor defect.7736897
Postprandial hyperlactemiaDeregulated Nutrient SensingIt is suggested that postprandial hyperlipidaemia is a characteristic trait of the insulin resistance syndrome and that the defect in lipid removal is related to the low HDL cholesterol in this syndrome.7738484
Cardiovascular DiseasesDeregulated Nutrient SensingThe insulin resistance syndrome is likely to be an important reason for the increased propensity for cardiovascular disease in smokers.7738484
Kidney Failure, Chronic, Electronic Source Report FormDeregulated Nutrient SensingPatients with end-stage renal failure (ESRF) on dialysis treatment have increased insulin resistance which is associated with hypersecretion of beta-cell products.7738722
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiabetes and glucose intolerance have been shown to increase the risk of cardiovascular mortality in a number of different populations.7743621
Glucose Intolerance (disease), Sudden death, Diabetes MellitusDeregulated Nutrient SensingThe relations seen in these analyses indicate that individuals with glucose intolerance or diagnosed diabetes are at increased risk for sudden death.7743621
Increased insulin levelDeregulated Nutrient SensingRelation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia.7749841
Lipemia - observationDeregulated Nutrient SensingWe examined the relation between insulin resistance, plasma glucose and insulin responses to meals, lipoprotein lipase (LPL) activity, and postprandial lipemia in a population of 37 healthy nondiabetic individuals.7749841
Steatohepatitis, Hyperinsulinism, Hypertension, CTCAEDeregulated Nutrient SensingAssociation between hepatic steatosis, insulin resistance and hyperinsulinaemia as related to hypertension in alcohol consumers and obese people.7752170
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, OverweightDeregulated Nutrient SensingIn overweight women with polycystic ovary syndrome (PCOS), increased insulin resistance has been observed.7752909
Spinal Cord Injuries, Depressed mood, DyslipidemiasDeregulated Nutrient SensingSeveral reports indicate that dyslipidemia, primarily depressed high density lipoprotein cholesterol, is common in persons with spinal cord injury.7753565
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingDietary change and obesity associated with glucose intolerance in Alaska Natives.7759744
Increased insulin level, ObesityDeregulated Nutrient SensingSeveral dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance.7761392
ObesityDeregulated Nutrient SensingTo examine whether increased PTPase activity is associated with adipose tissue insulin resistance in human obesity we measured PTPase enzyme activity towards the insulin receptor in homogenates of subcutaneous adipose tissue from a series of six lean and six nondiabetic, obese (body mass index > 30) subjects.7769120
ObesityDeregulated Nutrient SensingThese studies suggest that increased PTPase activity towards the insulin receptor is a pathogenetic factor in the insulin resistance of adipose tissue in human obesity and provide evidence for a potential role of the LAR PTPase in the regulation of insulin signalling in disease states.7769120
Infarction, Hypercholesterolemia, Dyslipidemias, Occlusion of artery (disorder)Deregulated Nutrient SensingCT-scan and MRI suggested temporal-parietal infarction due to Sylvian artery occlusion in a 9-month-old infant with familial hypercholesterolemia (type 2 A dyslipidemia).7779744
Weight GainDeregulated Nutrient Sensingto investigate whether increased insulin resistance is associated with a reduced risk of weight gain among Hispanic and non-Hispanic white persons in Colorado.7780493
Hypertension, CTCAEDeregulated Nutrient SensingThe association of hypertension with insulin resistance has been reported.7794582
Hypertension, CTCAEDeregulated Nutrient SensingThese results suggest that insulin resistance or plasma insulin level plays a role in the pathogenesis of essential hypertension.7794582
HyperinsulinismDeregulated Nutrient SensingInsulin resistance was presumed to develop in normal glucose tolerance subjects with hyperinsulinaemia.7806019
Chronic kidney disease stage 5, Dyslipidemias, physiopathologicalDeregulated Nutrient SensingDyslipidemia is one of the first metabolic dysfunction observed among patients with end stage renal disease.7808932
DyslipidemiasDeregulated Nutrient SensingThe findings are consistent with the hypothesis that in CESD increased intrahepatic synthesis of cholesterol stimulates hepatic secretion of VLDL apoB and this may partly account for the dyslipidemia.7813057
HyperinsulinismDeregulated Nutrient SensingThe present study provides further evidence that a relationship exists between blood pressure and hyperinsulinaemia or insulin resistance.7814857
Glucose Intolerance (disease)Deregulated Nutrient SensingCONCLUSIONS--This study highlights the high prevalence of glucose intolerance in elderly south Indians having low mean BMI (mean +/- SD; urban 21.7 +/- 4.6, rural 17.9 +/- 3.3 kg/m2).7821141
Hyperinsulinism, Data types - Address, OverweightDeregulated Nutrient SensingWe conclude that patients with AD have hyperinsulinaemia and insulin resistance, and this may be secondary to being overweight but a causal relationship cannot be excluded.7825486
Hepatosplenomegaly, Hypereosinophilia, Diabetic KetoacidosisDeregulated Nutrient SensingDue to the progression of hypereosinophilia, hepatosplenomegaly and peripheral lymphoadenopathy, severe insulin resistance associated with diabetic ketoacidosis occurred repeatedly, despite intravenous administration of over 1,000 U per day of human insulin.7827382
Diabetes Mellitus, Coronary heart diseaseDeregulated Nutrient SensingDiabetes mellitus caused by insulin resistance significantly contributes to early coronary heart disease in South Asian immigrant patients, in accordance with the literature on the present population of India.7830825
AtherosclerosisDeregulated Nutrient SensingThese findings strengthen the belief that genetic factor are important in the development of insulin resistance and atherosclerosis.7830825
Cancer-related fatigue, Acidosis, Chronic Kidney DiseasesDeregulated Nutrient SensingTo test the hypothesis that acidosis contributes to the insulin resistance of chronic renal failure (CRF) and impairs the action of insulin to decrease protein degradation, eight CRF patients were studied using the combined L-[1-13C]leucine-euglycemic clamp technique before (acid) and after (NaHCO3) 4 wk treatment with NaHCO3 (pH: acid 7.29 +/- 0.01 vs. NaHCO3 7.36 +/- 0.01, P < 0.001).7840169
Cancer-related fatigue, Acidosis, palladiumDeregulated Nutrient SensingIn conclusion, acidosis contributes to the insulin resistance of CRF but does not affect the action of insulin on PD.7840169
Hypertension, CTCAE, Turner Syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTurner syndrome is associated with insulin resistance, increased incidence of type II diabetes, and hypertension, all of which are cardiovascular risk factors.7844670
Diabetes MellitusDeregulated Nutrient SensingClinical and laboratory studies showed that plasmasorption used in multiple-modality treatment helps effectively control a purulent process, reduces intoxication of the body, corrects the development of insulin resistance in patients with maxillofacial phlegmons coursing in the presence of diabetes mellitus.7846708
Hypertension, CTCAE, Liver Cirrhosis, diabeticDeregulated Nutrient Sensing[Decrease of insulin resistance after splenectomy in a diabetic patient with liver cirrhosis and portal hypertension.7849151
Glucose Intolerance (disease), Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingLiver cirrhosis is characterized by an increased incidence of glucose intolerance, diabetes and insulin resistance.7849151
Cardiovascular Diseases, diabeticDeregulated Nutrient SensingRelationship between insulin resistance and risk factors for cardiovascular disease in Japanese non-insulin-dependent diabetic patients.7851274
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, diabetic, Complications of Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingTo investigate whether a resistance to insulin-stimulated glucose uptake (IR) is associated with the risk factors (RF) for cardiovascular disease (CVD) in non-insulin-dependent diabetic (NIDDM) patients, we determined the degree of IR in 135 adult NIDDM patients who had no advanced diabetic complications.7851274
Weight decreasedDeregulated Nutrient SensingThe results clearly showed the vigorous weight reduction conducted the significant decrease of the insulin resistance as well as normalizations of blood pressures and several biochemical parameters.7851833
Metabolic DiseasesDeregulated Nutrient SensingOur experience from the case suggested that insulin resistance may closely related with the metabolic disorders of the disease "syndrome X".7851834
Microalbuminuria, Hypertensive (finding)Deregulated Nutrient SensingTo examine whether microalbuminuria in non-diabetic, treated hypertensive men is associated with insulin resistance and measures of endothelial function, thrombogenesis and fibrinolysis.7852923
Microalbuminuria, ObesityDeregulated Nutrient SensingMicroalbuminuria was associated with insulin resistance but obesity was a confounding factor.7852923
Hypertensive (finding)Deregulated Nutrient SensingDyslipidaemias in white and black treated essential hypertensive patients.7853326
Glucose Intolerance (disease), Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingPlasma lipid abnormalities and risk factors for coronary artery disease in Japanese subjects with diabetes mellitus and glucose intolerance.7859608
Diabetes MellitusDeregulated Nutrient SensingWe suggest that a westernized lifestyle induces peripheral insulin resistance and promotes the development of diabetes among Japanese.7859631
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingBy the cooperation of members of the Japan Diabetes Society, we collected data on 144 twin pairs with diabetes or glucose intolerance.7859635
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingComparison of groups with varying degrees of glucose intolerance revealed that a family history of diabetes increased in parallel with the impairment of glucose tolerance.7859636
Glucose Intolerance (disease), metabolic disturbanceDeregulated Nutrient SensingGlucose intolerance was also associated with increased blood glucose concentration during the OGTT and with other metabolic disturbances such as increased serum lipids, increased blood pressure, and physical inactivity.7863144
Glucose Intolerance (disease), Liver CirrhosisDeregulated Nutrient SensingGlucose intolerance in liver cirrhosis: role of hepatic and non-hepatic influences.7865613
Glucose Intolerance (disease), Cholestasis, Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingThere was no association between glucose intolerance or diabetes and the aetiology of cirrhosis, the duration of the disease, the biochemical indicators of hepatocyte damage, cholestasis and/or liver function.7865613
Hepatobiliary Disorder, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAfter manifestation of liver disease, glucose intolerance or diabetes cannot be explained by the clinical, histological or biochemical signs of liver disease.7865613
Uremia, Glucose Intolerance (disease), Hyperparathyroidism, SecondaryDeregulated Nutrient SensingBefore calcitriol treatment, uraemic patients with secondary hyperparathyroidism displayed a significant higher triglyceride and a significant lower HDL-C and apoprotein A-I as well as marked glucose intolerance with an increment of the area below the glucose curve when compared with healthy control subjects.7874841
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingDiabetes was associated with advanced age, had a greater impact in the low-income group, and showed increased odds ratio for hypertension, dyslipidemias, and myocardial infarction in men and women and for obesity only in women.7882814
Glucose Intolerance (disease), NEUROD1 wt AlleleDeregulated Nutrient SensingConsumption of seal oil and salmon, high in omega-3 fatty acids, appears to lower the risk of glucose intolerance and is a potentially modifiable risk factor for NIDDM in Alaska Natives.7882827
Increased insulin level, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingHyperinsulinemia, which is considered a hallmark of insulin resistance, precedes the development of non-insulin-dependent diabetes mellitus (NIDDM).7883115
DyslipidemiasDeregulated Nutrient SensingAlthough heterozygosity for apo E1 alone did not impair the interaction of VLDL with cellular receptors in vitro, its presence in subjects with type III HLP suggests that apo E1, perhaps in combination with secondary factors, may be causative for the dyslipidemia.7883834
Increased insulin level, Hyperlipidemia, Atherosclerosis, Insulin resistance syndrome, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingThere is the accumulating evidence that chronic day-long hyperinsulinemia is associated with an insulin-resistance syndrome characterized by the development of hypertension, hyperlipidemia, atherosclerosis and non insulin depend diabetes.7885957
Obesity, AbdominalDeregulated Nutrient SensingThis finding suggests that regular aerobic exercise may prevent the age-associated increase in abdominal obesity and insulin resistance.7900795
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThese results suggest that long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensive patients and terazosin seems to be an antihypertensive agent with beneficial effects for hypertensive patients with either dyslipidemia or impaired glucose metabolism.7908168
Coronary heart diseaseDeregulated Nutrient SensingWe investigated the association between fasting insulin concentration--an indicator of insulin resistance in nondiabetic individuals--cardiovascular risk factors, and coronary heart disease in a study of 390 men in the town of Zutphen.7918315
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThese results suggest that perindopril can be used effectively to treat hypertension in patients with glucose intolerance without affecting glucose and lipid metabolism.7923313
TriglyceridesDeregulated Nutrient SensingInsulin resistance and hypertriacylglycerolaemia are part of the X syndrome and are supposed to be interrelated.7923327
TriglyceridesDeregulated Nutrient SensingHypertriacylglycerolaemia exists as an independent factor which is rather the consequence than cause of insulin resistance.7923327
DyslipidemiasDeregulated Nutrient SensingThe apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.7923858
Coronary Arteriosclerosis, NEUROD1 wt AlleleDeregulated Nutrient SensingEvidence of higher insulin resistance in NIDDM patients with ischaemic heart disease.7926345
NEUROD1 wt AlleleDeregulated Nutrient SensingIn NIDDM this association is less clear possibly due to the poor significance of insulin and C-peptide concentrations as an index of insulin resistance.7926345
Myocardial Ischemia, NEUROD1 wt AlleleDeregulated Nutrient SensingTherefore, only a direct measurement of insulin sensitivity could clarify the possible relationship between insulin resistance and IHD in NIDDM.7926345
Hypertension, CTCAEDeregulated Nutrient SensingAspects of insulin resistance in urbanisation-related hypertension in Zimbabwe: a preliminary report.7932509
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingInsulin resistance has been associated with essential hypertension, obesity and old age.7932509
Hypertension, CTCAEDeregulated Nutrient SensingThese findings suggest that insulin resistance may play a role in urbanisation-related hypertension.7932509
Hypertriglyceridemia, Obesity, diabeticDeregulated Nutrient SensingInsulin resistance is associated with hypertriglyceridemia and elevated free fatty acid (FFA) concentrations in obese and diabetic individuals, but it is unclear to what extent this relationship is independent of obesity and is present in healthy individuals.7934980
glycation, Dyslipidemias, Kidney Failure, Diabetes MellitusDeregulated Nutrient SensingModification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.7937786
Hyperthyroidism, Glucose Intolerance (disease)Deregulated Nutrient SensingDuring the day abnormally high postprandial blood glucose levels were seen, pointing to the glucose intolerance usually seen in the hyperthyroid state.7941923
Hyperthyroidism, Glucose Intolerance (disease), insulinoma, HypoglycemiaDeregulated Nutrient SensingAs shown in this case, concurrent hyperthyroidism and an insulinoma may lead to consecutive episodes of glucose intolerance and hypoglycemia within the same 24-hour period.7941923
No metabolic abnormalities, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes.7955995
Hypertension, CTCAEDeregulated Nutrient Sensing[The role of beta 2-adrenoceptor on the pathogenesis of insulin resistance in essential hypertension].7958101
Hypertension, CTCAEDeregulated Nutrient SensingThe role of beta 2-adrenoceptor on the pathogenesis of insulin resistance in essential hypertension (EH) was explored.7958101
Increased insulin levelDeregulated Nutrient SensingIn addition, hyperinsulinemia was observed during the 75g glucose tolerance test and the presence of insulin resistance was suggested.7959530
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient SensingHyperglycemia and glucose intolerance are characteristic of both the metabolic responses to injury and normal aging.7966476
Apolipoprotein E, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingApolipoprotein E alleles, dyslipidemia, and coronary heart disease.7966894
Apolipoprotein E, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingApolipoprotein E alleles are important genetic markers for dyslipidemia and CHD.7966894
Acanthosis NigricansDeregulated Nutrient SensingIt was concluded that acanthosis nigricans is highly prevalent among Native Americans and that its presence suggests insulin resistance.7977931
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThe findings suggest that obesity and cigarette smoking are important factors in the development of glucose intolerance in middle-aged Japanese men.7981843
Increased insulin levelDeregulated Nutrient SensingIn short-term studies (4 to 6 months) we have reported that antihypertensive treatment with beta-adrenergic blockade and thiazide diuretics induced insulin resistance, hyperinsulinemia, and a deranged lipid profile; the ACE inhibitor captopril increased insulin sensitivity without affecting serum lipids.7985599
Werner Syndrome, Diabetes MellitusDeregulated Nutrient SensingPrevious reports suggest that insulin resistance is involved in the development of diabetes associated with Werner's syndrome.7988348
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingGlucose intolerance was associated with high triglyceride, low HDL cholesterol and central obesity in European but not in Afro-Caribbean men.7988778
deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingThe pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and insulin deficiency.7989470
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingEssential hypertension is frequently associated with insulin resistance and hyperinsulinemia.7995624
Hypertensive (finding)Deregulated Nutrient SensingIt is concluded that salt restriction may increase insulin resistance in hypertensive patients.7997846
Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingPatients with non-insulin-dependent diabetes mellitus (NIDDM) exhibit insulin resistance and decreased glucose transport in skeletal muscle.8013748
NEUROD1 wt AlleleDeregulated Nutrient SensingThe newly-diagnosed NIDDM patients mostly suffered from diseases related to the insulin resistance syndrome, and we thus recommend measurement of non-fasting blood-glucose as a screening procedure in such patients.8016951
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe most common risk factors in the young group were dyslipidemia (67%) and cigarette smoking (65%), and in the octogenarian group were dyslipidemia (52%) and hypertension (50%).8021047
Primary malignant neoplasm, Weight decreased, NeoplasmsDeregulated Nutrient SensingEffects of tumor removal and body weight loss on insulin resistance in patients with cancer.8023270
Weight decreased, NeoplasmsDeregulated Nutrient SensingThis study was conducted to evaluate the effects of tumor removal and body weight loss on insulin resistance.8023270
Primary malignant neoplasm, Malnutrition, NeoplasmsDeregulated Nutrient SensingOur results would suggest that insulin resistance in patients with cancer was not caused by cancer-associated malnutrition but at least in part by tumor itself.8023270
Glucose Intolerance (disease), Fibrosis Assessment, Beta-cell dysfunctionDeregulated Nutrient SensingRoles of insulin resistance and beta-cell dysfunction in the pathogenesis of glucose intolerance in cystic fibrosis.8027259
deficiency aspects, Glucose Intolerance (disease)Deregulated Nutrient SensingWe conclude that 1) glycohemoglobin is a strong correlate of insulin deficiency in CF; and 2) glucose intolerance in this group of CF patients occurred as a consequence of concomitant insulin deficiency and insulin resistance.8027259
Impaired, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingIn conclusion obesity causes not only glycemic impairment, but also atherogenic alterations of plasma lipidic parameters "per se" and/or through insulin-resistance; therefore it must be considered a pathologic condition or, at least, a risk factor of cardio-vascular diseases and treated with the greatest care.8028743
Glucose Intolerance (disease)Deregulated Nutrient SensingSerum calcium increased glucose intolerance from 1.76 to 2.0, 2.08, 1.96 and 2.0 mmol/l, respectively; vitamin D reached supraphysiological levels initially and returned to normal levels, and parathyroid hormone levels were normalized.8029165
Neuropathy, Dyslipidemias, Retinal Diseases, Kidney Diseases, Hypertension, CTCAEDeregulated Nutrient SensingAs a group these prisoners were obese with a high prevalence of smoking, hypertension, dyslipidaemia, retinopathy, nephropathy and neuropathy.8035969
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensinghad a high percentage of risks factors (diabetes mellitus 55%, nicotinism 85%, dyslipidemia 22.5%) and history of previous myocardial infarction in 33% of cases.8038989
Uremia, Glucose Intolerance (disease)Deregulated Nutrient SensingDisturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia.8041868
Left Ventricular HypertrophyDeregulated Nutrient SensingWe found that LVH in men is associated with indices of enhanced sympathetic nervous system reactivity and with elevated fasting insulin and triglyceride levels, which may be caused by insulin resistance.8044964
Left Ventricular Hypertrophy, Hypertension, CTCAE, HyperkineticDeregulated Nutrient SensingWe suggest that early LVH in young men is a manifestation of hyperkinetic borderline hypertension, a state previously shown to be associated with increased sympathetic nervous system activity and insulin resistance.8044964
Coronary heart diseaseDeregulated Nutrient SensingIt recently has been hypothesized that increased plasma plasminogen activator inhibitor-1 (PAI-1) activity could be a possible link between insulin resistance and coronary heart disease.8049187
Cardiac complication, NEUROD1 wt AlleleDeregulated Nutrient SensingPeripheral, rather than hepatic, insulin resistance and atherogenic lipoprotein phenotype predict cardiovascular complications in NIDDM.8050454
Microalbuminuria, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingA cross-sectional study from our Department showed that peripheral insulin resistance, hypertension, microalbuminuria and lipid abnormalities are associated in NIDDM.8050454
Extrahepatic, HyperinsulinismDeregulated Nutrient SensingHowever, it is unknown to what extent hyperinsulinaemia reflects resistance to insulin action at hepatic, extrahepatic or at both sites.8050454
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus.8053615
Dyslipidemias, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingTo assess clinical efficacy and tolerability of cholestyramine therapy in patients with dyslipidemia and non-insulin-dependent diabetes mellitus (NIDDM).8053615
Increased insulin level, diabeticDeregulated Nutrient SensingKnown and newly diagnosed diabetic patients were excluded from this study, since serum insulin and C-peptide levels are indicators of insulin resistance and hyperinsulinemia in non-diabetics only.8059770
Increased insulin level, OverweightDeregulated Nutrient SensingBesides overweight, physical activity and dietary factors such as the intake of fatty acids, fiber, carbohydrates, and alcohol, were independently associated with hyperinsulinemia and insulin resistance.8059770
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with non-insulin-dependent diabetes mellitus (NIDDM) are at high risk of cardiovascular disease for many reasons and especially due to the fact that dyslipidemias are more frequent in this group of patients.8067175
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance--not hyperinsulinemia--is pathogenic in essential hypertension.8072428
Hypertension, CTCAEDeregulated Nutrient SensingA correlation between essential hypertension and insulin resistance/hyperinsulinemia is well documented, and there is adequate reason to believe that this association is causal.8072428
Hypertension, CTCAEDeregulated Nutrient SensingCorrection of insulin resistance usually aids blood pressure control, and in addition may mitigate the excess cardiovascular risk associated with hypertension.8072428
diabeticDeregulated Nutrient SensingTo study the effect of insulin and sulfonylurea (SU) therapy on glycaemic control, insulin resistance and cardiovascular risk factors in type 2 diabetic subjects.8077888
Hyperlipidemia, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient Sensing[Prevalences of diabetes, glucose intolerance, hyperlipemia and risk factors as a function of socioeconomic level].8079061
Dyslipidemias, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingDespite the significant role that dyslipidemia is believed to play in the development of cardiovascular disease in diabetes, most studies examining diabetic dyslipidemia in the United States have not been population based, and very little data are available for African Americans with diabetes.8087927
Dyslipidemias, atherosclerotic, NEUROD1 wt AlleleDeregulated Nutrient SensingIn African-American and white men and women in the United States, NIDDM is associated with a pattern of dyslipidemia that may potentiate the atherosclerotic process.8087927
Dyslipidemias, diabeticDeregulated Nutrient SensingDiabetic treatment should include aggressive treatment of dyslipidemia to reduce this increased risk.8087927
Primary malignant neoplasmDeregulated Nutrient SensingWhole body glucose use was 55% lower in patients than in control subjects (17 +/- 3 mumol/kg/minute versus 38 +/- 3 mumol/kg/minute, P = 0.002), consistent with insulin resistance in cancer.8111717
Glucose Intolerance (disease), Liver CirrhosisDeregulated Nutrient SensingIn conclusion, glucose intolerance in cirrhosis results from two abnormalities that occur simultaneously: (a) insulin resistance of muscle and (b) an inadequate response (even when comparable to that of controls) of the beta-cells to appropriately secrete insulin to overcome the defect in insulin action.8119686
Hyperglycemia, Impaired health, Cirrhotic, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus in insulin-resistant cirrhotic patients develops as the result of progressive impairment in insulin secretion together with the development of hepatic insulin resistance leading to fasting hyperglycemia and a diabetic glucose tolerance profile.8119686
Glucose Intolerance (disease), Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingPathogenesis of glucose intolerance and diabetes mellitus in cirrhosis.8119686
Glucose Intolerance (disease), Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance and diabetes mellitus are both prevalent in cirrhosis, yet the pathogenesis of impaired glucose metabolism remains unknown.8119686
ObesityDeregulated Nutrient SensingConfluent and reticulated papillomatosis: a case with concurrent acanthosis nigricans associated with obesity and insulin resistance.8136544
Dyslipidemias, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingSeveral studies have indicated that insulin resistance, elevated blood pressure (BP), and dyslipidemia precede the onset of non-insulin-dependent diabetes mellitus (NIDDM).8138060
Increased insulin levelDeregulated Nutrient SensingSeveral studies have shown that hyperinsulinemia and insulin resistance are associated with high triglyceride and low high-density lipoprotein (HDL) cholesterol levels.8148350
Increased insulin levelDeregulated Nutrient SensingHowever, previous studies have been cross-sectional, and thus the presence of hyperinsulinemia or insulin resistance could be a consequence of the underlying lipid disorder instead of its cause.8148350
TG gene, NEUROD1 wt AlleleDeregulated Nutrient SensingThe results suggest that in NIDDM (1) insulin sensitivity is determined mainly by percentage body fat and REE, (2) the insulin level determines the TG level directly, whereas the lipoproteins are influenced indirectly as a reflection of the degree of insulin resistance, and (3) insulin sensitivity is not related to blood pressure in a normotensive population.8159111
Increased insulin levelDeregulated Nutrient SensingThe sympathoadrenal system therefore, along with hyperinsulinemia, may contribute to the increased cardiovascular risk associated with the insulin resistance syndrome.8159112
DyslipidemiasDeregulated Nutrient SensingThese data suggest that (1) epinephrine plays an important role in regulating lipid and lipoprotein metabolism in humans, and (2) decreased adrenal medullary activity may contribute to the dyslipidemia (increased triglycerides and decreased HDL-C) commonly observed among the obese.8159112
thromboembolic, Diabetes Mellitus, Cerebrovascular accident, Hemorrhagic, Glucose Intolerance (disease)Deregulated Nutrient SensingThis study was conducted to determine whether glucose intolerance and diabetes increase the risk of thromboembolic, hemorrhagic, and total stroke independent of other risk factors.8165689
Obesity, Abdominal, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingIn South Asians (Indians, Pakistanis, and Bangladeshis) settled overseas, high rates of coronary disease and non-insulin-dependent diabetes occur in association with central obesity and insulin resistance.8172093
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingIt is concluded that acute mental stress induces a state of insulin resistance in IDDM patients, which can be demonstrated by an IGIT to appear 1 h after maximal stress and to last more than 5 h.8174837
Amino Acid Metabolism, Inborn ErrorsDeregulated Nutrient SensingObesity-associated hyperaminoacidemia is traditionally interpreted as a consequence of insulin resistance.8177054
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingWe performed two different experiments to investigate the effects of both obesity-associated insulin resistance and the insulin resistance of non-insulin-dependent diabetes mellitus (NIDDM) on amino acid metabolism.8177054
Hypertension, CTCAEDeregulated Nutrient SensingWe were interested to know the extent of insulin resistance in a group of young, non-obese patients with hypertension.8185276
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension, dyslipidemia, and diabetes mellitus should be treated.8187462
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingMarkers on chromosome 4q have recently been shown to be associated with insulin resistance in Pima Indians, a population in which insulin resistance precedes and predicts the development of non-insulin-dependent diabetes mellitus (NIDDM).8194666
NEUROD1 wt AlleleDeregulated Nutrient SensingThe U.K. NIDDM population was selected for insulin resistance by studying patients whose obesity-corrected fasting plasma insulin before treatment was above the 98th percentile.8194666
Coronary ArteriosclerosisDeregulated Nutrient SensingLewis phenotypes, insulin resistance, and risk of ischaemic heart disease.8198876
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingAlthough mutations in the glucokinase gene are implicated in the pathogenesis of glucose intolerance in pedigrees with maturity-onset diabetes of the young, the role of such mutations in typical Type 2 diabetes is poorly characterized.8200207
Stanford Cancer InstituteDeregulated Nutrient SensingSCI subjects had significantly higher mean glucose and insulin values at several points during the OGTT when compared with controls, suggesting an accentuated state of insulin resistance in those with SCI.8201966
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and glucose intolerance have been suggested to be involved in the pathogenesis of various cardiovascular diseases.8206582
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingRole of glucose intolerance in cardiac diastolic function in essential hypertension.8206582
Heart Diseases, Glucose Intolerance (disease), NeoplasmsDeregulated Nutrient SensingWe would urge caution in the use of this form of therapy, particularly in older patients who may have occult neoplasms, impaired glucose intolerance or pre-existing cardiac disease.8208913
Pancreatic carcinoma, Neoplasms, Diabetes MellitusDeregulated Nutrient SensingThe diabetes mellitus that occurs in patients with pancreatic cancer is characterized by marked insulin resistance that declines after tumor resection.8277951
Diabetes MellitusDeregulated Nutrient SensingSince IAPP may cause insulin resistance, its overproduction may contribute to the diabetes that occurs in these patients.8277951
Glucose Intolerance (disease), Hypertriglyceridemia, Hypertension, CTCAEDeregulated Nutrient SensingThe associates of gout-obesity, hypertriglyceridemia, glucose intolerance, and hypertension, strikingly resemble those of insulin resistance.8288709
HyperuricemiaDeregulated Nutrient SensingIn the present study we determined whether hyperuricemia is associated with insulin resistance and, if so, whether this association can be explained by other components of the syndrome.8288709
Angina PectorisDeregulated Nutrient SensingInsulin resistance, lipoproteins, body fat and hemostasis in nonobese men with angina and a normal or abnormal coronary angiogram.8294690
Increased insulin level, Hypertension, CTCAE, Coronary heart disease, Congenital AbnormalityDeregulated Nutrient SensingRisk factors for coronary heart disease, including lipoprotein abnormalities, hypertension and adiposity, may be metabolically interlinked, with insulin resistance and hyperinsulinemia being pivotal to these disturbances.8294690
Increased insulin level, Coronary heart diseaseDeregulated Nutrient SensingThese findings provide new evidence of the central role of insulin resistance and hyperinsulinemia in the development of risk factors associated with coronary heart disease.8294690
Increased insulin level, Glucose Intolerance (disease), HypertriglyceridemiaDeregulated Nutrient SensingIn conclusion, LDL cholesterol metabolism improved in hypercholesterolemic subjects treated with pravastatin, but the hypertriglyceridemia, insulin resistance, relative glucose intolerance, and hyperinsulinemia present in patients with type IIB HLP either did not improve with treatment or was somewhat worse.8296701
Hypertension, CTCAE, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance may be a mechanism linking non-insulin-dependent diabetes mellitus (NIDDM) to hypertension and cardiovascular mortality.8314023
Hyperinsulinism, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and not hyperinsulinaemia determines erythrocyte Na+/Li+ countertransport in non-insulin-dependent diabetes mellitus.8523391
Hypertension, CTCAE, HyperinsulinismDeregulated Nutrient SensingInsulin resistance and increased erythrocyte Na+/Li+ countertransport activity are well documented in subjects with essential hypertension, raising the question whether compensatory hyperinsulinaemia might be responsible for activating Na+/Li+ countertransport.8523391
HyperinsulinismDeregulated Nutrient SensingIt is concluded that increased Na+/Li+ countertransport may be a cellular marker for insulin resistance, but that hyperinsulinaemia is not likely to be the factor which mediates this relation.8523391
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese observations suggest that the homozygous Arg252-->His mutation is responsible for the type A insulin resistance of the proband, whereas in the heterozygous state, the mutation results in mild insulin resistance indistinguishable from that observed in noninsulin-dependent diabetes mellitus.8530617
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia is an important risk factor for atherosclerotic vascular disease.8534686
Diabetes MellitusDeregulated Nutrient SensingTo conclude, plasma TBARS were increased in impaired glucose tolerance and in diabetes and they were related to prevailing plasma glucose and insulin levels, suggesting a role for insulin resistance in increased lipid peroxidation process.8542741
Diabetes Mellitus, Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance increases during adolescence, and is exaggerated in patients with insulin dependent diabetes mellitus (IDDM).8548941
Increased insulin level, Ischemic strokeDeregulated Nutrient SensingRole of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke.8553400
Increased insulin level, Ischemic stroke, AtherosclerosisDeregulated Nutrient SensingAlthough insulin resistance and hyperinsulinemia play a crucial role in the pathogenesis of atherosclerosis, little is known about their roles in ischemic stroke.8553400
Increased insulin level, Ischemic strokeDeregulated Nutrient SensingThe purpose of this study was to clarify whether insulin resistance and hyperinsulinemia are causative factors in the pathogenesis of ischemic stroke.8553400
Cerebrovascular accidentDeregulated Nutrient SensingSteady state plasma glucose levels were significantly higher in the atherothrombotic infarction group compared with control subjects and the other two stroke groups, indicating the presence of insulin resistance in patients with atherothrombotic infarction.8553400
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingInsulin resistance in association with compensatory hyperinsulinemia and dyslipidemia may be an important pathogenetic factor underlying the development of atherothrombotic infarction.8553400
Neuropathy, Hyperglycemia, Dyslipidemias, GDC Comorbidity Terminology, Diabetes Mellitus, diabetic, Diabetes Mellitus, Insulin-Dependent, Hypoglycemia, CDISC SDTM Lesion Complexity Terminology, Obesity, Kidney Diseases, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient Sensing1) On the basis of data from intervention trials in IDDM that prove that intensive glycemic control reduces microvascular and neuropathic complications, coupled with epidemiologic and basic scientific data that support the strong likelihood of a similar benefit in NIDDM, the goal of treatment in NIDDM should be near-normal glycemia (glycohemoglobin level no higher than 1.0% above the upper normal limit); 2) glycemic targets should be adjusted individually according to clinical factors such as increased risk for hypoglycemia, advanced age, or reduced life expectancy from comorbid conditions; 3) some degree of comprehensive and repetitive instruction about diet and exercise and the use of blood glucose self-monitoring for all patients is essential to achieve the chosen targets; 4) intensive management of hyperglycemia should be instituted early and should initially emphasize diet and exercise therapy; staged introduction of oral hypoglycemic agents and finally insulin regimens of increasing complexity are recommended as needed to achieve glycemic targets; 5) comprehensive care must also include aggressive attempts to reduce cardiovascular risk factors (particularly hypertension, smoking, dyslipidemia, and obesity) as well as prevention of nephropathy and neuropathy; 6) the complex interaction among treatment regimens for hyperglycemia, dyslipidemia, obesity, and hypertension ideally requires a team approach, using a physician, diabetes educator, nurse, dietitian, and other health professionals; health insurers should make these resources available to generalists who currently care for most diabetic patients.8554214
Atherosclerosis, NEUROD1 wt Allele, Diabetes MellitusDeregulated Nutrient SensingOther areas of discussion centered on basic research, that is, the fundamental cause of insulin resistance and the genetics of NIDDM and the loss of protection against atherosclerosis in postmenopausal women with diabetes.8554215
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese coordinated actions indicate that physical training is able to influence the mechanisms of type 2 diabetes with insulin resistance when the etiology of type 1 diabetes is not influenced by physical training.8556419
TraumaticDeregulated Nutrient SensingInsulin resistance and autonomic function in traumatic lower limb amputees.8563461
Kidney Diseases, Hypertrophy, HyperlipoproteinemiasDeregulated Nutrient SensingACE inhibitors and calcium antagonists are otherwise for diabetics drugs of first choice which can arrest the progression of nephropathy, effectively reduced the blood pressure without causing deterioration of insulin resistance and hyperlipoproteinaemia and lead even to regression of hypertrophy of the vascular wall and left ventricle.8578695
Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingGlycaemic control alone is often insufficient to control diabetic dyslipidaemia and other cardiovascular risk factors associated with NIDDM.8582541
Retinal DiseasesDeregulated Nutrient SensingIndeed, in patients with inadequate metabolic control, the prevalence of retinopathy was significantly increased in those with higher endogenous insulin secretion (51.4 versus 20.6%, p < 0.02) and thus probably higher insulin resistance.8586152
Dyslipidemias, Ascites, HepatomegalyDeregulated Nutrient SensingA regimen of dietary lipid restriction, gemfibrozil, and niacin resulted in significant but partial improvement of the dyslipidemia and resolution of the hepatomegaly and ascites.8589283
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThus, although patients with mitochondrial gene mutation had a high frequency of diabetes, the proportion of mutant DNA evaluated by blood samples may not necessarily indicate glucose intolerance in the members with the mutation.8591702
Proteinuria, Dyslipidemias, diabetic, Diabetes Mellitus, Retinal Diseases, Hypertension, CTCAE, Non-compliance, Breast Fibrocystic Change, Non-Proliferative TypeDeregulated Nutrient SensingThe factors analyzed were: diabetic (non-proliferative and proliferative) retinopathy, family histories of diabetes and hypertension, smoking, dyslipidemia, first examination proteinuria and non-compliance.8591710
Microvascular Angina, diabeticDeregulated Nutrient SensingPrevalence of macro- and microvascular diseases in non-insulin-dependent diabetic and borderline glucose-intolerant subjects with insulin resistance syndrome.8591713
Microvascular AnginaDeregulated Nutrient SensingWe conclude that the insulin resistance syndrome preferentially increases the development of CAD, and is also involved in the progression of microvascular diseases.8591713
Cardiovascular DiseasesDeregulated Nutrient SensingThe results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account.8591825
Glucose Intolerance (disease), HyperinsulinismDeregulated Nutrient SensingGlucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men.8591825
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance in essential hypertensive patients with impaired glucose tolerance.8593759
Increased insulin level, Hypertensive (finding), Glucose Intolerance (disease)Deregulated Nutrient SensingThese data show that in hypertensive patients without glucose intolerance insulin resistance might compensatorily augment second-phase insulin secretion and lead to hyperinsulinemia.8593759
Increased insulin level, Glucose Intolerance (disease), Hyperglycemia, Postprandial, Antihypertensive AgentsDeregulated Nutrient SensingIn hypertensives with glucose intolerance, insulin resistance might induce postprandial hyperglycemia, which leads to hyperinsulinemia because of second phase insulin secretion at a level similar to that of normotensives.8593759
Hypertensive (finding), Glucose Intolerance (disease)Deregulated Nutrient SensingThe hypertensive patients without glucose intolerance showed a significantly lower insulin-mediated glucose disposal and a compensating increase in second-phase insulin secretion compared with normotensives without glucose intolerance.8593759
Glucose Intolerance (disease), Antihypertensive AgentsDeregulated Nutrient SensingIn hypertensives with glucose intolerance, insulin-mediated glucose disposal was significantly lower and second-phase insulin secretion was comparable to that in normotensives without glucose intolerance.8593759
Glucose Intolerance (disease), Antihypertensive AgentsDeregulated Nutrient SensingAfter 3 months of angiotensin-converting enzyme (ACE) inhibition with oral administration of delapril, blood pressure was significantly reduced in the hypertensives with glucose intolerance (n = 9).8593759
Hyperlipidemia, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingHyperlipidemia associated with non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance is characterized by high triglyceride levels; raised levels of total low-density lipoprotein (LDL), which is made up of small, dense, cholesterol-rich particles; low levels of high-density lipoprotein (HDL); and glycosylation of apolipoproteins.8595642
DyslipidemiasDeregulated Nutrient SensingA comparison of lovastatin, an HMG-CoA reductase inhibitor, with gemfibrozil, a fibrinic acid derivative, in the treatment of patients with diabetic dyslipidemia.8595642
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe prevalence of clinically recognized hypertension and dyslipidemia increased 8.5-fold and 3.1- to 8.3-fold, respectively, in the overweight cohort versus the lean cohort (P < .05 to P < .0001).8596496
Increased insulin level, Glucose Intolerance (disease), Obesity, Diabetes MellitusDeregulated Nutrient SensingThis study presents evidence for a continuum form obesity to diabetes via glucose intolerance and hyperinsulinemic diabetes.8597498
Non-insulin Hypoglycemic, Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingTo establish whether the relation between size at birth and non-insulin dependent diabetes is mediated through impaired beta cell function or insulin resistance.8601111
ObesityDeregulated Nutrient SensingThis relation seems to be mediated through insulin resistance rather than through impaired beta cell function and to depend on an interaction with obesity in adult life.8601111
metabolic disturbanceDeregulated Nutrient SensingMetabolic disturbances, possibly related to insulin resistance, may provide a pathway through which fetal growth affects blood pressure.8601110
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance was observed only in the subjects with overt diabetes.8603770
Massive Osteolyses, Glycogen Storage Disease, Dyslipidemias, DiseaseDeregulated Nutrient SensingLiver glycogen storage diseases (GSD) are disorders associated with severe dyslipidaemia which can induce cell membrane alterations.8611649
Cardiac complication, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingIn addition to the typical dyslipidemia found in CAPD patients, high levels of Lp(a) and fibrinogen may contribute to the elevated risk of coronary artery disease and other cardiovascular complications.8616169
Diabetes MellitusDeregulated Nutrient SensingIslet amyloid polypeptide is currently studied with regard to a role for insulin resistance in non-insulin-dependent diabetes.8616529
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAs adults, individuals with consistently elevated insulin versus those with consistently decreased insulin had increased (P<.05) prevalence of obesity (36-fold), hypertension (2.5-fold), and dyslipidemia (3-fold), which was attributed to both baseline insulin and change of insulin from baseline to follow-up.8616941
Increased insulin level, Glucose Intolerance (disease), CirrhoticDeregulated Nutrient SensingIn conclusion, these results suggest that hyperinsulinemia may be implicated in the glomerular hyperfiltration and sodium retaining tendency of preascitic cirrhotic patients with glucose intolerance.8617419
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of symptoms was often associated with the duration of diabetes and poor glycemic control as were complications, but complications were often also associated with dyslipidemias and an elevated mean arterial pressure.8620254
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingOur results indicate that hyperinsulinemia is associated with high factor VII activity in a general Japanese population as well as with high blood pressure and dyslipidemia.8620342
Cardiovascular Diseases, NEUROD1 wt AlleleDeregulated Nutrient SensingThere is limited evidence that raised hematocrit levels may be associated with insulin resistance, which links cardiovascular disease with NIDDM.8621006
Increased insulin level, Metabolic Diseases, Dyslipidemias, Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingFurthermore, our findings suggest that abnormalities in fibrinolytic function in older hypertensive men are likely due to the primary effects of other metabolic disorders that usually accompany hypertension, such as hyperinsulinemia and dyslipidemia.8621196
Acanthosis NigricansDeregulated Nutrient SensingInsulin resistance frequently accompanies endocrine-associated acanthosis nigricans.8621823
Acanthosis Nigricans, HyperandrogenismDeregulated Nutrient SensingWe describe a patient with acanthosis nigricans associated with hyperandrogenism and extreme insulin resistance that spontaneously resolved after a marked decrease in insulin receptor antibodies.8621823
Weight GainDeregulated Nutrient SensingRelationship of insulin resistance to weight gain in nondiabetic Asian Indian, Creole, and Chinese Mauritians.8622608
ObesityDeregulated Nutrient SensingThere is evidence from animal models that postprandial insulin hypersecretion may precede the development of obesity and insulin resistance, but it is not clear if this is the case in humans.8622608
Weight GainDeregulated Nutrient SensingRecently, two longitudinal studies have suggested that insulin resistance acts to limit further weight gain rather than to promote it.8622608
Weight GainDeregulated Nutrient SensingInsulin resistance predicted weight gain in Chinese men independently of baseline age and BMI.8622608
Weight GainDeregulated Nutrient SensingThese data provide suggestive but not convincing evidence that insulin resistance may limit weight gain, and contradictory evidence in one ethnic group that insulin resistance promotes weight gain.8622608
Coronary Stenosis, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingNo subjects had overt diabetes mellitus, hypertension, dyslipidemia, obesity or angiographically detected significant baseline coronary stenosis.8626958
Hyperlipidemia, Muscle hypertrophy, Fatty Liver, Hyperglycemia, Hirsutism, Hepatomegaly, Acanthosis NigricansDeregulated Nutrient SensingThe diagnosis is made on the basis of loss of body fat, muscular hypertrophy, acanthosis nigricans, hirsutism, hepatomegaly with fatty liver, hyperlipidemia and hyperglycemia with insulin resistance.8629139
ObesityDeregulated Nutrient SensingThe authors conclude that, in addition to significant genetic influences on fasting insulin, environmental or behavioral factors (particularly nongenetic variation in obesity) are important determinants of fasting insulin and the insulin resistance syndrome.8633616
HypersensitivityDeregulated Nutrient SensingThere have been rare reports of allergic reactions to endogenously secreted insulin manifested as insulin resistance.8634879
HyperinsulinismDeregulated Nutrient SensingHowever, this observation was not confirmed by other studies and is still a matter of controversy; furthermore, it is not known whether it represents a primary event or is secondary to hyperinsulinaemia and insulin resistance.8635675
Hyperinsulinism, insulinomaDeregulated Nutrient SensingIn order to address this issue in patients with pure non-genetically determined hyperinsulinaemia, we examined the alternative splicing of insulin receptor mRNAs in skeletal muscle of eight patients with surgically confirmed insulinoma and insulin resistance and in eight healthy subjects, using the reverse transcriptase-polymerase chain reaction technique.8635675
Ataxia Telangiectasia, Diabetes MellitusDeregulated Nutrient SensingWe conclude that insulin resistance and islet beta-cell dysfunction are characteristics of diabetes mellitus in ataxia-telangiectasia.8638204
Dyslipidemias, Infection, Cataract, Polyuria, Diabetic Retinopathy, Kidney Diseases, NocturiaDeregulated Nutrient SensingWhen their sugars are controlled, older diabetics will have less nocturia and polyuria; fewer infections; better wound healing; a decrease in the rate of progression of cataracts, diabetic retinopathy, and nerve and renal disease; and better control of dyslipidemia.8641590
Glucose Intolerance (disease), Jaundice, ObstructiveDeregulated Nutrient SensingGlucose intolerance and impaired insulin secretion are often associated with obstructive jaundice.8644011
Glucose Intolerance (disease), Cushing SyndromeDeregulated Nutrient SensingFactors influencing the development of glucose intolerance in Cushing syndrome.8651039
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAdverse levels of LDL-C in childhood persist over time, progress to adult dyslipidemia, and relate to obesity and hypertension as well.8651840
Mortality, Premature, Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingHealth risks also increase with excess abdominal/visceral fat (as estimated by a waist-hip ratio [WHR] > 1.0 for males and > 0.8 for females), high blood pressure (> 140/90), dyslipidemias (total cholesterol and triglyceride concentrations of > 200 and > 225 mg/dl, respectively), non-insulin-dependent diabetes mellitus, and a family history of premature death due to cardiovascular disease (e.g., parent, grandparent, sibling, uncle, or aunt dying before age 50).8653537
ThrombosisDeregulated Nutrient SensingA possible cause of accelerated atherothrombosis in the syndrome of insulin resistance appears to be an elevated blood concentration of plasminogen activator inhibitor type-1 (PAI-1).8669417
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingWhen to treat dyslipidaemia of patients with chronic renal failure on haemodialysis?8671784
Cancer-related fatigue, Dyslipidemias, Chronic Kidney Diseases, AtherosclerosisDeregulated Nutrient SensingThere are no specific recommendations for management of dyslipidaemia in patients with chronic renal failure (CRF) on haemodialysis, in which atherosclerosis is a common cause of morbidity and mortality.8671784
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingThese results clearly demonstrated that duration of diabetes, smoking, hypertension, and dyslipidemia are major risk factors for MA in NIDDM patients.8674883
Hypertension, CTCAE, Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, in nonobese NIDDM patients, age, hypertension, and dyslipidemia were found to be risk factors for MA.8674883
Injury of kidneyDeregulated Nutrient SensingInsulin resistance, elevated glomerular filtration fraction, and renal injury.8675252
Hypertension, CTCAEDeregulated Nutrient SensingThe development of insulin resistance may be an early step in the development of hypertension; however, the mechanism for this process is not known.8675252
Hypertension, CTCAE, Injury of kidneyDeregulated Nutrient SensingThe worsening of insulin resistance and hypertension could increase both systemic and glomerular capillary pressures and predispose an individual to renal injury.8675252
Hypertensive (finding), Injury of kidneyDeregulated Nutrient SensingThis suggests that a greater degree of insulin resistance, not increased dietary salt, may predispose older mildly hypertensive subjects to renal injury by worsening renal hemodynamics through the elevation of glomerular filtration fraction and resultant glomerular hyperfiltration.8675252
AtherosclerosisDeregulated Nutrient SensingThe insulin resistance atherosclerosis study (IRAS) objectives, design, and recruitment results.8680609
Increased insulin levelDeregulated Nutrient SensingForthcoming cross-sectional analyses will help to disentangle the association between insulin resistance and CVD, apart from the concomitant hyperinsulinemia and related CVD risk factors.8680609
DyslipidemiasDeregulated Nutrient SensingA high frequency of dyslipidemia was found among UDDM group in our study.8683643
Tuberculosis, Pulmonary, Glucose Intolerance (disease)Deregulated Nutrient SensingThe frequency of glucose intolerance was studied in 106 patients with pulmonary tuberculosis attending Nazimabad Chest Clinic.8683828
Glucose Intolerance (disease), Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance was detected in 52 (49%) patients, 31 Impaired Glucose Tolerance (IGT), 21 Diabetes Mellitus (DM).8683828
Dyslipidemias, HyperinsulinismDeregulated Nutrient SensingDyslipidaemia and hyperinsulinaemia have been proposed as aetiological factors.8689846
Impaired T cell function, NEUROD1 wt AlleleDeregulated Nutrient SensingThis suggests that beta cell dysfunction, rather than increased insulin resistance, is responsible for the development of NIDDM.8689855
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance and impaired insulin secretion are thought to be the primary defects in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM).8690169
TG gene, Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingFrequency of dyslipidemia in the studied sample was 24.4% for high TG, 23.6% for low HDL-C, 23.6% for high LDL-C, 14.9% for Lp(a) excess (Lp(a) > or = 30 mg/dl; overweight and obesity were more prevalent among women.8696067
Graves Disease, Glucose Intolerance (disease)Deregulated Nutrient SensingUntreated Graves' disease was associated with glucose intolerance due to quantitative as well as qualitative beta-cell defects.8706294
Coronary Artery DiseaseDeregulated Nutrient SensingDemonstration of insulin resistance in coronary artery disease documented with angiography.8720524
Coronary Artery Disease, AtherosclerosisDeregulated Nutrient SensingTo evaluate the relation between insulin resistance and coronary atherosclerosis, insulin sensitivity in lean nondiabetic, normotensive subjects with and without obstructive coronary artery disease (CAD).8720524
Coronary StenosisDeregulated Nutrient SensingThe correlation between insulin resistance and degree of coronary stenosis was also investigated.8720524
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingHyperinsulinemia in the presence of insulin resistance aggravates dyslipidemia and may stimulate the atheromatous process by an as-yet-unknown mechanism.8720524
Glucose Intolerance (disease)Deregulated Nutrient SensingIncreased proinsulin and proinsulin-to-insulin molar ratio in elderly, but not in obese, subjects without glucose intolerance.8720525
Amyloidosis, NEUROD1 wt AlleleDeregulated Nutrient SensingHowever, the question remains whether chronic overstimulation of insulin and islet amyloid polypeptide (IAPP) secretion in states of insulin resistance could lead to formation of islet amyloidosis and hence NIDDM in some patients.8720529
Familial generalized lipodystrophyDeregulated Nutrient SensingWe studied pancreatic islet pathology in congenital generalized lipodystrophy, a genetic syndrome of extreme insulin resistance that may provide some clues.8720529
AmyloidosisDeregulated Nutrient SensingThese observations suggest that chronic presence of extreme insulin resistance may induce premature and severe islet amyloidosis as well as beta-cell atrophy.8720529
Hyperproinsulinemia, Increased insulin levelDeregulated Nutrient SensingThese results indicate that when specific assays for insulin are used, Asian subjects show postglucose load hyperinsulinemia and fasting hyperproinsulinemia compared with white subjects, suggesting increased insulin secretion and/or the presence of underlying insulin resistance in this ethnic group.8720531
Beta-cell dysfunction, Diabetes MellitusDeregulated Nutrient SensingThese results suggest that beta-cell dysfunction rather than insulin resistance plays the most important role in the future development of diabetes in a high-risk Caucasian population.8720611
HyperglycemiaDeregulated Nutrient SensingLaboratory examination showed hyperglycemia, increased glycosilated hemoglobin (HbA1c) and insulin resistance on euglycemic glucose clamp.8723046
DyslipidemiasDeregulated Nutrient SensingOur data indicates that this mutation may be a relatively common cause of dyslipidemia in the Spanish population.8724110
Hypertension, CTCAEDeregulated Nutrient SensingWhereas insulin resistance was higher in patients with hypertension, the increase in insulin resistance with age was much more apparent in normotensive patients, resulting in similar insulin levels at high ages.8728302
Increased insulin levelDeregulated Nutrient SensingThe results of this study show that hyperinsulinemia is associated with raised blood pressure in elderly people, and suggest that the age-associated increase in insulin resistance is diminished in patients with raised blood pressure.8728302
hydroxyurea, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia occurred with the highest prevalence (p = 0.36), the highest positive predictive value (v = 0.44) and, together with HU and diabetes, the highest nosologic specificity (f = 0.55 in both cases).8730125
DyslipidemiasDeregulated Nutrient SensingHis brother also had typical features of CTX without the presence of dyslipidaemia.8730343
ObesityDeregulated Nutrient SensingThere was an increase of proinsulin related to obesity and increased glucose levels, suggesting that proinsulin levels increase with insulin resistance.8731348
Hypertension, CTCAEDeregulated Nutrient SensingIt is suggested that insulin resistance was associated with sodium sensitivity, and they might play a role in the development of hypertension in childhood.8731845
DyslipidemiasDeregulated Nutrient SensingHowever, dyslipidemia appears to manifest only if VLDL production is also increased.8732773
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingHyperinsulinemia was the major determinant of excessive VLDL synthesis and dyslipidemia among the subjects heterozygous for the A291S mutation in this study.8732773
Hypertension, CTCAEDeregulated Nutrient SensingImpaired fibrinolysis and insulin resistance in patients with hypertension.8735180
Hypertension, CTCAEDeregulated Nutrient SensingPatients with hypertension were further subdivided into two groups: insulin resistance (SSPG > 190 mg/dL, n = 14) and no insulin resistance (SSPG < 190 mg/dL, n = 14).8735180
Hypertensive (finding)Deregulated Nutrient SensingAs compared to normal controls, hypertensive patients, either with or without insulin resistance, had a significant (P < .005) increases in PAI-1 activity (18.6 +/- 1.3 upsilon 8.1 +/- 0.8 IU/mL), PAI-1 antigen (31.1 +/- 2.0 upsilon 12.7 +/- 0.9 ng/mL) and tPA antigen (15.5 +/- 0.9 upsilon 8.8 +/- 0.9 ng/mL), and significant decrease in tPA activity (0.43 +/- 0.05 upsilon 1.02 +/- 0.16 IU/mL) than normotensive controls.8735180
Hypertensive (finding)Deregulated Nutrient SensingFurthermore, hypertensive patients with insulin resistance had significantly higher PAI-1 activity (22.0 +/- 2.2 upsilon 15.3 +/- 0.8 IU/mL, P = .006) and tPA antigen (17.4 +/- 1.2 upsilon 13.6 +/- 1.3 ng/mL, P = .02) than did hypertensive patients without insulin resistance.8735180
Hypertensive (finding)Deregulated Nutrient SensingHowever, PAI-1 antigen was insignificantly higher (34.1 +/- 2.9 upsilon 28.1 +/- 2.4 ng/mL, P = .06) and tPA activity insignificantly lower (0.42 +/- 0.08 upsilon 0.43 +/- 0.08 IU/mL, P = .47) in hypertensive patients with insulin resistance than in those without insulin resistance.8735180
Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingThus, patients with hypertension have impaired fibrinolytic activity due to increased PAI-1 when compared to normotensive controls, and the magnitude of this fibrinolytic defect is greater in hypertensive patients who have insulin resistance.8735180
No metabolic abnormalities, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance with associated metabolic abnormalities may be one of the causes for impaired fibrinolysis in hypertension.8735180
Gestational Diabetes, Exceptionally large baby (disorder), Glucose Intolerance (disease)Deregulated Nutrient SensingIn patients with GDM the degree of glucose intolerance (determined by FBG on the GTT) and maternal weight were the only variables that significantly increased the risk of macrosomia and operative delivery.8735291
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia in patients with chronic renal failure and in renal transplant patients.8737552
Glucose Intolerance (disease), Diabetes Mellitus, NEUROD1 wt Allele, Beta-Cell Function MeasurementDeregulated Nutrient SensingThe findings suggest that in this age group in a Caucasian population, not only does insulin resistance precede glucose intolerance and NIDDM, but also loss of early insulin response indicating impaired beta-cell function to be an early feature of the process culminating in diabetes.8739917
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance and impaired insulin secretion can be involved in the development of non-insulin-dependent diabetes mellitus (NIDDM), but their relative importance or temporal relationship are poorly understood.8745206
NEUROD1 wt AlleleDeregulated Nutrient SensingWe conclude that the increased insulin secretion compensates for the peripheral insulin resistance of subjects with slightly deteriorated glucose tolerance, implying that insulin resistance plays an important role in the pathogenesis of NIDDM in some fraction of Japanese population.8745206
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingTo elucidate this issue, we studied 51 subjects with borderline glucose intolerance (BGI) and 18 normal glucose tolerant subjects (NGT) according to the Japan Diabetes Society criteria.8745206
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance and hyperinsulinemia have been linked with essential hypertension.8747309
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingAge-associated increases in glucose intolerance and hypertension are also well established.8747309
Senile cataract, DyslipidemiasDeregulated Nutrient SensingSome persons with treatable disorders such as senile cataract and dyslipidaemia were also detected by the screening programme.8758055
Increased insulin level, Hypertensive (finding)Deregulated Nutrient SensingHypertensive patients frequently show resistance to insulin-stimulated glucose uptake and hyperinsulinemia.8761899
Hypertensive (finding), Overweight, Glucose Intolerance (disease)Deregulated Nutrient SensingPeople with the following attributes: female, overweight, hypertensive and with glucose intolerance were those with more concern about health and prevention.8762691
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIntracellular fat may underlie a major part of the insulin resistance in normal subjects, as well as type II diabetics.8769349
Diabetes MellitusDeregulated Nutrient SensingLack of a relationship between urinary albumin excretion rate and insulin resistance in patients with non-insulin-dependent diabetes mellitus.8781291
Microalbuminuria, NEUROD1 wt AlleleDeregulated Nutrient SensingThus, resistance to insulin-mediated glucose disposal occurs in patients with NIDDM in the absence of microalbuminuria, and we could not detect any relationship between UAE and insulin resistance in this population.8781291
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThe study was performed to determine the relationship between urinary albumin excretion (UAE) and resistance to insulin-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM).8781291
Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingNon-insulin dependent diabetes mellitus (NIDDM) affects more than 100 million people worldwide and is associated with severe metabolic defects, including peripheral insulin resistance, elevated hepatic glucose production, and inappropriate insulin secretion.8782826
Glucose Intolerance (disease), ParesisDeregulated Nutrient SensingAffected individuals also have proximal muscle weakness, facial involvement, nonspecific abnormalities on muscle biopsy, normal cardiac conduction, and no glucose intolerance.8784800
Uremia, Dyslipidemias, Diabetic AngiopathiesDeregulated Nutrient SensingDyslipidemia possibly contributes to the vascular complications commonly afflicting uremic patients.8785232
NEUROD1 wt AlleleDeregulated Nutrient SensingTherefore, mutations in the HK2 gene could contribute to skeletal muscle insulin resistance in NIDDM.8786021
NEUROD1 wt AlleleDeregulated Nutrient SensingThe data thus seem to rule out mutations in the HK2 gene as a major cause of inherited insulin resistance in NIDDM.8786021
Microvascular Angina, HyperlipoproteinemiasDeregulated Nutrient SensingInsulin resistance and hyperlipoproteinemia in microvascular angina: risk factors or pathogenetic link?8789672
Hyperlipoproteinemias, Microvascular Angina, Hypertensive heart diseaseDeregulated Nutrient SensingThe metabolic profile in patients with microvascular angina suggests a pathogenetic role of insulin resistance and hyperlipoproteinemia in the setting of impaired myocardial coronary reserve and in early stages of hypertensive heart disease.8789672
Increased insulin levelDeregulated Nutrient SensingLong-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance.8790020
Increased insulin levelDeregulated Nutrient SensingLong-term use of nicotine-containing chewing gum was associated with insulin resistance and hyperinsulinemia.8790020
Cardiovascular morbidity, No metabolic abnormalitiesDeregulated Nutrient SensingThese findings suggest that nicotine is the major constituent in cigarette smoke that leads to insulin resistance, metabolic abnormalities associated with the insulin resistance syndrome, and increased cardiovascular morbidity.8790020
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingHigh glycosylated hemoglobin levels increase the risk of progression to diabetes mellitus in subjects with glucose intolerance.8792104
Glucose Intolerance (disease), NEUROD1 wt AlleleDeregulated Nutrient SensingThe results showed that the combination of HbA1c level and OGTT enables more precise prediction of progression to NIDDM in subjects with glucose intolerance.8792104
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHigh prevalence of dyslipidaemia despite adequate glycaemic control in patients with diabetes.8799011
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe suggest that an active strategy of early detection and drug treatment for dyslipidaemia is needed for patients with diabetes mellitus.8799011
Diabetes Mellitus, Insulin-Dependent, HypoglycemiaDeregulated Nutrient SensingInsulin-dependent diabetic women may rarely develop exaggerated insulin sensitivity in the first trimester of pregnancy resulting in severe hypoglycaemia, but spontaneous improvement occurs with increasing insulin resistance in the second and third trimesters.8799666
HyperglycemiaDeregulated Nutrient SensingAlimentary hyperglycemia in patients with subtotal gastrectomy is associated with decreased insulin secretion but not with insulin resistance.8803702
HyperglycemiaDeregulated Nutrient SensingThese results suggest that in patients with alimentary hyperglycemia, glucose tolerance was impaired due to a decreased pancreatic sensitivity to blood glucose and not due to insulin resistance.8803702
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient SensingPatients were categorized into three groups by OGTT; 8 cases were in group I (normal), 19 cases in group II (alimentary hyperglycemia), and 9 cases in group III (glucose intolerance).8803702
diabetic, Insulin resistance syndromeDeregulated Nutrient SensingThe population is characterized by a large percentage of elderly patients, diabetic patients, and patients with the clinical characteristics of the insulin-resistance syndrome.8806347
Glucose Intolerance (disease), Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThis suggests that RT has the potential to ameliorate and perhaps prevent the development of insulin resistance and may reduce the risk for glucose intolerance and non-insulin-dependent diabetes mellitus (NIDDM) in postmenopausal women.8808989
Electrocardiogram abnormal, Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingElectrocardiographic abnormalities and other cardiovascular risk factors were common among these hypertensives, with dyslipidaemia, past or current smoking and lack of physical exercise being present in the majority of those studied.8809371
Non-insulin Hypoglycemic, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance characterizes non-insulin dependent diabetes (NIDDM).8813436
Hyperestrogenism, HyperandrogenismDeregulated Nutrient SensingInsulin resistance may coexist in clinical syndromes with hyperestrogenism and hyperandrogenism, suggesting that the ovary may be sensitive to effects of insulin.8813436
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingElevated plasma cholesteryl ester transfer protein (CETP) mass is characteristic of combined hyperlipidaemia (CHL), an atherogenic dyslipidaemia characterized by increased levels of both very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) and subnormal levels of high-density lipoprotein (HDL).8817163
Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore, pharmacological intervention should aim to improve insulin sensitivity.8817248
UremiaDeregulated Nutrient SensingAbnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance.8820510
Schistosomiasis, Glucose Intolerance (disease), Pancreatic Diseases, Diabetes MellitusDeregulated Nutrient Sensingglucose load in children with schistosomiasis suggest that auto-immune aggression against the islet cells contributes in the pathogenesis of pancreatic disease in these patients, and might increase the risk for developing glucose intolerance and diabetes.8820621
Microalbuminuria, Glucose Intolerance (disease)Deregulated Nutrient SensingHigher prevalence rates of micro- and macroalbuminuria were also found among Arizona participants than participants with similar degrees of glucose intolerance from the other two sites.8821844
Glucose Intolerance (disease), AcromegalyDeregulated Nutrient SensingThese results indicate that octreotide improves insulin resistance at the insulin receptor site by lowering plasma levels of GH and insulin in acromegalic patients with glucose intolerance.8822314
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingBefore octreotide therapy, 2 patients had normal responses of plasma glucose and insulin to 75-g OGTT (normal glucose tolerance: NGT) and 4 showed hyperinsulinemia or glucose intolerance (glucose intolerance: GIT).8822314
Increased insulin level, NEUROD1 wt AlleleDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients.8827527
Depression, CTCAE, OverweightDeregulated Nutrient SensingWe concluded that: (1) data indicative of insulin resistance correlated to both depression and sleep alterations; (2) overweight is related to NSSD, sleep alterations, and hormonal changes.8834092
Chronic disease, ObesityDeregulated Nutrient SensingThe differential effect of obesity on glucose, blood pressure, and lipid levels in the Inuit compared with non-Inuit suggests a type of selective insulin resistance, the underlying mechanism of obesity and several chronic diseases.8838915
Dyslipidemias, Sialorrhea, Abdominal PainDeregulated Nutrient SensingDyslipidaemia in a boy with recurrent abdominal pain, hypersalivation and decreased lipoprotein lipase activity.8839720
Acanthosis Nigricans, Syndrome, Diabetes MellitusDeregulated Nutrient SensingAbsence of acanthosis nigricans in a patient with the type B syndrome of insulin resistance and preexisting diabetes.8842610
cell wall thickeningDeregulated Nutrient SensingInsulin resistance as an independent risk factor for carotid wall thickening.8843883
Hypertension, CTCAE, Carotid Intima-Media ThicknessDeregulated Nutrient SensingIn conclusion, insulin resistance was the strongest risk factor for carotid intima-media thickness, followed by lower high-density lipoprotein cholesterol and hypertension.8843883
Congenital AbnormalityDeregulated Nutrient SensingThese results suggest that in salt-sensitive essential hypertensives increased pressor responses to angiotensin and norepinephrine and elevation of BP as well as insulin resistance may result from inherited abnormalities of intracellular calcium metabolism.8846505
AtherosclerosisDeregulated Nutrient SensingFemoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance.8857823
AtherosclerosisDeregulated Nutrient SensingThe authors also evaluated the association of insulin resistance with atherosclerosis in a cross-sectional setting.8857823
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe association of the G-A mutation at np 3316 with glucose intolerance suggests the importance of this area for the development of diabetes.8858117
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance in non-obese hypertensive subjects--its role in free fatty acid metabolism.8858377
Hypertension, CTCAE, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingNon insulin dependent diabetes mellitus (NIDDM) and essential hypertension (EH) are two of several manifestations of the insulin resistance syndrome.8860097
Diabetes MellitusDeregulated Nutrient SensingLevels of von Willebrand factor, insulin resistance syndrome, and a common vWF gene polymorphism in non-insulin-dependent (type 2) diabetes mellitus.8862946
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingTo examine the association between von Willebrand Factor (vWF) concentrations and features of the insulin resistance syndrome, 208 patients with Type 2 (non-insulin-dependent) diabetes (NIDDM) and 80 healthy controls were studied.8862946
NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, these findings show vWF concentrations are elevated in NIDDM and are weakly related to features of the insulin resistance syndrome.8862946
Hypertension, RenovascularDeregulated Nutrient SensingIn conclusion, renovascular hypertension is not associated with insulin resistance.8864417
Glucose Intolerance (disease), Liver carcinoma, Liver CirrhosisDeregulated Nutrient Sensing[Glucose intolerance after percutaneous ethanol injection therapy (PEI) in liver cirrhosis patients with hepatocellular carcinoma].8865748
UremiaDeregulated Nutrient SensingIt could be explained, at least in part, by the insulin resistance present in uremia.8865877
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingDespite controlling for physician selection, we demonstrated increased rates of abdominal delivery, glucose intolerance, and hypertension in older patients.8866293
HypogonadismDeregulated Nutrient SensingIt has been suggested that a relative hypogonadism might be a primary event, because other studies have shown that testosterone deficiency is followed by insulin resistance, which is ameliorated by testosterone substitution.8866567
Hypertensive (finding)Deregulated Nutrient SensingTo establish the prevalence of insulin resistance in hypertensive subjects.8866908
Hypertensive (finding)Deregulated Nutrient SensingA similar prevalence of insulin resistance in hypertensive patients was found (31%) if the 95th percentile of the non-normally distributed insulin sensitivity index (M/I at clamp) was used to define the cutoff limit for insulin resistance: (4.4 mg/kg per min)/(mU/l x 100).8866908
Non-insulin Hypoglycemic, Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance in hypertension was also associated with an increased heart rate (+3 beats/min faster than in non-insulin resistant hypertensive patients, P < 0.01), but no significant differences in blood pressure were found between insulin resistant and non-insulin resistant hypertensive patients.8866908
Hyperglycemia, Hypertensive (finding), Diabetes MellitusDeregulated Nutrient SensingWhen insulin resistance was defined as an M-value at clamp of < 4.4 mg/kg per min, based on calculations from a healthy control sample, about 25% of a sample of hypertensive subjects, taking no antihypertensive treatment and with no history of diabetes mellitus or hyperglycaemia, was found to be insulin resistant.8866908
LipolysisDeregulated Nutrient SensingThus, insulin resistance in ageing appears selective on glucose utilization, inhibition of lipolysis and feedback inhibition of the B-cell secretion.8872059
teratologic, NEUROD1 wt Allele, Cardiovascular DiseasesDeregulated Nutrient SensingThe constellation of anomalies associated with insulin resistance is a plausible additional cause of ischemic cardiovascular disease and of NIDDM.8875083
TG gene, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingIn both groups, glucose intolerance was associated with increasing age, higher BMI, WHR, BP, Ualb, serum TG, and insulin levels as well as higher prevalence rates of positive family history of diabetes.8875088
Hypertensive (finding)Deregulated Nutrient SensingA prediction model for estimating insulin resistance in hypertensive patients is presented.8879599
Hypertension, CTCAE, Coronary heart diseaseDeregulated Nutrient SensingThese findings suggest that risk to coronary heart disease and hypertension through insulin resistance already operates in school-aged children.8886342
Weight Gain, Glucose Intolerance (disease)Deregulated Nutrient SensingPoor pregnancy weight gain was associated with the late development of glucose intolerance (P < .001).8887193
ObesityDeregulated Nutrient SensingSerum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study.8892415
HyperinsulinismDeregulated Nutrient SensingThe relation with insulin independent of body mass index suggests a possible role for leptin in insulin resistance or hyperinsulinaemia.8892415
Hyperinsulinism, NEUROD1 wt AlleleDeregulated Nutrient SensingThis data suggests that insulin resistance, or hyperinsulinaemia, does not play a major role in the development of NIDDM in Korea.8894474
NEUROD1 wt AlleleDeregulated Nutrient SensingTaken together with the rarity of obese NIDDM in Korea, it maybe suggested that the insulin secretory capacity of Korean people being smaller than Western people they cannot compensate for the insulin resistance imposed by recent changes in life style.8894474
Cell secretion, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance and secretory defects seem to be present in Swedish obese elderly, NIDDM subjects.8894488
Hyperinsulinism, NEUROD1 wt AlleleDeregulated Nutrient SensingIn the Japanese-Americans, diminished early insulin release to an oral glucose challenge and increased insulin resistance characterized by hyperinsulinaemia are suspected to be some of the important risk factors for NIDDM.8894497
Hyperglycemia, Dyslipidemias, NEUROD1 wt Allele, Cardiovascular DiseasesDeregulated Nutrient SensingAlthough classic cardiovascular risk factors are operative in subjects with NIDDM, other factors closely related to insulin resistance syndrome such as diabetic dyslipidemia and hyperglycemia itself may contribute to an excessive cardiovascular disease risk in subjects with NIDDM.8898803
NEUROD1 wt AlleleDeregulated Nutrient SensingThe main determinants of IMT in NIDDM patients were related to both postglucose insulin levels and abnormal lipoprotein profiles characteristic of NIDDM and insulin resistance syndrome.8898803
Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore, pharmacological intervention should aim to improve insulin sensitivity.8901147
Hyperlipidemia, Apolipoprotein EDeregulated Nutrient SensingEffect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients.8902145
ObesityDeregulated Nutrient SensingRecent studies have suggested that a missense Trp64Arg mutation in the beta3 adrenergic receptor (ADRB3) gene was involved in obesity and insulin resistance.8903328
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingInsulin resistance was related to obesity, but not to a family history of hypertension, as had previously been reported by other research groups.8906517
Hypercholesterolemia, Glucose Intolerance (disease), Hypertriglyceridemia, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of hypercholesterolemia, hypertriglyceridemia, hypertension, and overweight rose with increasing degrees of glucose intolerance.8908393
Obesity, Diabetes MellitusDeregulated Nutrient SensingEfforts to prevented diabetes should be focused on ways to reduce insulin resistance and obesity.8922541
HyperuricemiaDeregulated Nutrient SensingThese data indicate that, already in young, essentially health subjects, hyperuricaemia associates with several components of the so-called insulin resistance syndrome, thus suggesting that increased levels of uric acid might be another member of this syndrome.8923153
Hyperuricemia, ObesityDeregulated Nutrient SensingIn addition, these data suggest that obesity and central body fat distribution, rather than hyperinsulinaemia/insulin resistance, play a major role in linking hyperuricaemia with CVD risk factors clustering in the insulin resistance syndrome.8923153
Osteogenesis, Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingFrom this study, obesity was shown to be the major risk factor of ossification of the nucal ligament, and obesity and glucose intolerance were risk factors in ossification of the anterior longitudinal ligament and ossification of the posterior longitudinal ligament.8923634
Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingFood additive eikonol is recommended for wide administration in elderly NIDDM patients with atherogenic dyslipidemias.8926697
Cerebrovascular Disorders, Dyslipidemias, Coronary Artery Disease, Cerebrovascular accidentDeregulated Nutrient SensingAlthough dyslipidemia is a well established risk factor for coronary artery disease, its relationship to ischemic cerebrovascular disease has remained unclear, perhaps because of the heterogeneous nature of strokes.8929151
Increased insulin level, Sick Sinus Syndrome, Diabetes MellitusDeregulated Nutrient SensingAssociation of sick sinus syndrome with hyperinsulinemia and insulin resistance in patients with non-insulin-dependent diabetes mellitus: report of four cases.8929644
Increased insulin level, NEUROD1 wt AlleleDeregulated Nutrient SensingBecause insulin is a physiological regulator of cell-membrane Na+/K+-ATPase, we speculate that malfunction of the sinus node automaticity may be caused by chronic exposure to hyperinsulinemia secondary to insulin resistance in these NIDDM patients.8929644
Muscle CrampDeregulated Nutrient SensingThus, partial PGAM deficiency, insulin resistance and mild diabetic sensory-motor polyneuropathy can induce severe cramps.8933190
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt is also applied to dyslipidemia in patients with diabetes mellitus.8935222
Generalized amyotrophyDeregulated Nutrient Sensinginsulin resistance or skeletal muscle wasting, may be suggested by the present data.8938547
Beta-cell dysfunction, NEUROD1 wt AlleleDeregulated Nutrient SensingWe conclude that both beta-cell dysfunction and insulin resistance are present in first-degree relatives of NIDDM.8946153
Glucose Intolerance (disease), Beta-cell dysfunctionDeregulated Nutrient SensingThe progression of beta-cell dysfunction and glucose intolerance with age suggests that beta-cell dysfunction is the key factor in the apparition and progression of the disease.8946153
Glucose Intolerance (disease)Deregulated Nutrient SensingWe conclude that glucose intolerance is associated with impaired peripheral large-fibre nerve function, an association which seems to apply even in the non-diabetic range.8946154
NEUROD1 wt Allele, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, diabeticDeregulated Nutrient SensingObesity and insulin resistance are important risk factors for the development of noninsulin-dependent diabetes (NIDDM) and are prevalent among predisposed first degree relatives of diabetic individuals.8954053
Obesity, Diabetes MellitusDeregulated Nutrient SensingRecent molecular screening and analysis of a common missense mutation of the beta 3-adrenergic receptor gene suggested this locus as a strong candidate for increased obesity, earlier age of diabetes onset, and insulin resistance.8954053
NEUROD1 wt AlleleDeregulated Nutrient SensingWe conclude that the beta 3-adrenergic receptor locus does not play an important role in NIDDM susceptibility or in the insulin resistance syndrome among members of families with a strong predisposition to NIDDM.8954053
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThese results show that Papua New Guineans are by no means protected from dyslipidemia and serve warning that, unless effective preventative strategies can be developed, this and similar rapidly developing populations can expect an increasing incidence of coronary heart disease.8956625
insulinoma, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe conclude that insulin resistance was caused by postreceptor changes in obese Type 2 diabetes, whereas a decreased insulin binding capacity together with post-receptor defect was present in insulinoma patients.8960900
Fatty degenerationDeregulated Nutrient SensingIncreased steatosis of the liver is associated with reduced insulin clearance, contributing to insulin resistance in non-diabetic Japanese men and women.8963349
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThe Trp64-->Arg allele of the beta 3-adrenergic receptor gene was recently proposed to be associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), features of insulin resistance and a tendency to gain weight.8968849
Increased insulin level, Diabetes Mellitus, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingObesity is a common component of non-insulin-dependent diabetes mellitus (NIDDM) and plays an important role in the development of insulin resistance and hyperinsulinemia.8969285
Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingIt has been assumed that the etiology for this increased rate of NIDDM is related to the morbid obesity and concomitant insulin resistance, but this remains controversial.8969285
Health Information Exchange, ObesityDeregulated Nutrient SensingIn summary, this study demonstrates that nondiabetic PWS subjects manifest (1) a reduced beta-cell response to glucose stimulation, (2) a significantly increased HIE compared with obese controls, and (3) a dissociation of obesity and insulin resistance, in contrast to normal obese subjects.8969285
Increased insulin level, Obesity, Abdominal, Hyperglycemia, Dyslipidemias, Hostility, Hypertension, CTCAE, FatigueDeregulated Nutrient SensingIn 90 middle-aged male volunteers, psychosocial stress-related variables, defined as feelings of excessive tiredness and as personality and behavioral factors reflecting a stress-inducing life-style (type A behavior, hostility, and anger), were significantly correlated with the hyperinsulinemia, hyperglycemia, dyslipidemia, hypertension, increased abdominal obesity, and increased plasminogen activator inhibitor-1 (PAI-1) antigen comprising the IRS.8969288
Obesity, Abdominal, Hostility, Dyslipidemias, FatigueDeregulated Nutrient SensingHostility was related to elevated systolic blood pressure (SBP) and elevated triglycerides (TGs) (canonical r = .38, chi2(14) = 23.2, P = .052), whereas feelings of excessive tiredness were related to abdominal obesity, augmented glycemic responses to glucose ingestion, dyslipidemia, and increased PAI-1 antigen (canonical r = .39, chi2(24) = 36.8, P = .046).8969288
Increased insulin levelDeregulated Nutrient SensingCigarette smoking is not associated with hyperinsulinemia: evidence against a causal relationship between smoking and insulin resistance.8969291
Hyperinsulinism, NEUROD1 wt AlleleDeregulated Nutrient SensingAlthough insulin has been shown to stimulate ovarian steroidogenesis and hyperinsulinaemia has been implicated in the raised androgen levels found in diseases associated with significant insulin resistance, ovarian function has not been studied so far in women with NIDDM.8977760
Increased insulin level, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingHyperinsulinemia was defined as fasting insulin > or = 95th percentile (20 microU/mL) among the subset of subjects (n = 504) who were nonobese and free of clinical diabetes and glucose intolerance.8978879
Insulin resistance syndromeDeregulated Nutrient SensingGenetic and environmental architecture of the features of the insulin-resistance syndrome.8981957
Insulin resistance syndromeDeregulated Nutrient SensingThe contribution of genetic and environmental effects to the clustering of metabolic factors contained in insulin-resistance syndrome (IRS) is still unclear.8981957
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingBody mass index was higher in subjects with glucose intolerance, but the frequency of obesity showed a relative decrease with worsening of glucose tolerance.8982019
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThese results show that glucose intolerance, especially impaired glucose tolerance and undetected diabetes mellitus, is common in the elderly.8982019
Dyslipidemias, Cerebrovascular accident, Myocardial Ischemia, Diabetes MellitusDeregulated Nutrient SensingDiastolic blood pressures were significantly lower (p < 0.05) in patients with stroke and in those with ischemic heart disease, diabetes mellitus, or dyslipidemia, as compared with patients with no comorbidity.8986459
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance in patients with a recent diagnosis of coronary artery disease.8986933
Coronary Artery DiseaseDeregulated Nutrient SensingTo elucidate whether insulin resistance is present in coronary artery disease (CAD) at diagnosis and to study its relationship with other known cardiovascular risk factors.8986933
CDISC SDTM Immunogenicity Specimen Assessments Test Name TerminologyDeregulated Nutrient SensingThe IST consisted of a constant infusion of glucose, insulin and somatostatin for 150 min; insulin resistance was estimated by determining the steady-state plasma glucose (SSPG) concentrations during the last 60 min of the test.8986933
Coronary ArteriosclerosisDeregulated Nutrient SensingThese results suggest that insulin resistance might play a role in the development of coronary atherosclerosis and that its early diagnosis might be important in the prophylaxis of CAD.8986933
CCL21 protein, humanDeregulated Nutrient SensingIn this young adult African-American population, elevated SLC activity is detected in association with metabolic and lipid alterations typical of insulin resistance.9002529
Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingThe activity of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is associated with insulin resistance (IR) and the risk of venous and arterial thrombotic cardiovascular disease (CVD) in the general population, and may behave as an acute-phase reactant.9005966
Hypertension, CTCAEDeregulated Nutrient SensingTrp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system.9008254
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingA putative pathogenic mutation in the beta3-adrenergic receptor gene (Trp64Arg) has been reported to be associated with higher diastolic blood pressure as well as clinical features of the insulin resistance syndrome and an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians and Finns.9008254
Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingBecause essential hypertension is reported to be associated with insulin resistance, we studied the mutation in Japanese patients with essential hypertension to clarify associations of this mutation with hypertension, insulin resistance, and basal adrenergic state in hypertensive subjects.9008254
Hypertension, CTCAEDeregulated Nutrient SensingThese data suggest that Trp64Arg mutation in the beta3-adrenergic receptor gene does not play a major role in susceptibility to essential hypertension or in insulin resistance and basal adrenergic state in hypertension.9008254
Coronary heart diseaseDeregulated Nutrient SensingMost discussions of relations of insulin resistance to coronary heart disease risk factors have focused on insulin-stimulated glucose uptake, but insulin suppression of plasma free fatty acid (FFA) levels is also important in lipid and lipoprotein metabolism.9012639
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingTo identify groups with impaired insulin suppression of FFAs, we studied a multiethnic cohort of 1521 women and men at four US centers that comprise the Insulin Resistance Atherosclerosis Study (IRAS): 682 with normal glucose tolerance, 352 with impaired glucose tolerance, and 487 with non-insulin-dependent diabetes.9012639
Noncommunicable DiseasesDeregulated Nutrient SensingWe could also observe a varying degree of transition in cardiovascular risks related to insulin resistance from the rural to the urban area with rapid emergence of non-communicable diseases as a result of modernization.9015672
NEUROD1 wt AlleleDeregulated Nutrient SensingIn contrast, the peptide does not seem to improve insulin resistance in NIDDM.9024239
DyslipidemiasDeregulated Nutrient SensingFurthermore, children with this LDL subclass showed increased body fatness and dyslipidemia, including elevated plasma triglyceride and apolipoprotein (apo) B concentrations and decreased plasma high-density lipoprotein (HDL) cholesterol and apo A-I concentrations, compared with children without this phenotype.9030819
Obesity, Abdominal, Diabetes Mellitus, diabetic, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingPrompted by the recent findings that a tryptophan to arginine (Trp64Arg) mutation in the beta3-adrenergic receptor gene was associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians, with abdominal obesity and insulin resistance in Finns, and with an increased capacity to gain weight in French whites, we studied the prevalence of this mutation in 231 diabetic and 95 nondiabetic Japanese subjects and assessed its contribution to the development of obesity and NIDDM.9030829
Dyslipidemias, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, although the Trp64Arg mutation is not uncommon in Japanese, it does not appear to be associated with obesity, NIDDM, age at diagnosis of NIDDM, or dyslipidemia.9030829
Coronary heart diseaseDeregulated Nutrient SensingThere was no evidence of insulin resistance as a major pathogenic factor in the group with coronary heart disease.9036291
Increased insulin level, Diabetes MellitusDeregulated Nutrient SensingMost studies suggest that the maximum benefit from exercise is most likely to occur in patients with mild diabetes in whom insulin resistance and hyperinsulinemia are present (i.e.9036570
Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingMost patients with cirrhosis have insulin resistance and impaired glucose tolerance, and 20% eventually develop diabetes.9039943
NEUROD1 wt Allele, MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)Deregulated Nutrient SensingIn contrast to patients with NIDDM, MODY3 patients did not show any features of the insulin resistance syndrome.9045858
Hyperglycemia, physiopathologicalDeregulated Nutrient SensingRelationship of insulin resistance to microvascular dysfunction in subjects with fasting hyperglycaemia.9049487
HyperinsulinismDeregulated Nutrient SensingThese results suggests that hyperinsulinaemia, as a result of insulin resistance, may have a detrimental effect on microvascular function in the prediabetic state.9049487
Cardiovascular DiseasesDeregulated Nutrient SensingThe prevalence of insulin resistance and other cardiovascular disease risk factors in healthy elderly southwestern Nigerians.9050777
Hyperinsulinism, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient Sensingthe subjects had a relatively high prevalence of multiple CHD risk factors (about 20% had > 4 risk factors), an observation considered paradoxical in view of the reportedly low CHD prevalence in this population; (iii) these CHD risk factors (increased body mass and blood pressure (BP), hyperinsulinaemia and insulin resistance) were more prevalent in the women and in urban residents; (iv) hyperinsulinaemia (20%) and insulin resistance (35%) were common in the population, and were associated, on regression analyses, to such other CHD risk factors as BP and body mass, particularly in women, suggesting, as in Caucasians, that insulin resistance could be an important index of CHD risk; and (v) the excess of multiple CHD risk factors in the women, is due at least in part, to their increased tendency to obesity (8%) and reduced physical activity (83%).9050777
Arteriosclerosis, Dyslipidemias, DiseaseDeregulated Nutrient Sensing[Incidence of dyslipidemia and diseases associated with arteriosclerosis in a hospital population].9053820
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia is a major risk factor for atherosclerosis in adults and children.9057686
Dyslipidemias, Retinal Diseases, Kidney Diseases, ObesityDeregulated Nutrient SensingAN was associated with retinopathy, with nephropathy (only in IDDM), and with BP levels, but not with dyslipidemia, smoking, or obesity.9069569
Primary malignant neoplasm, Gall Bladder Diseases, Gout, Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Arthritis, Respiration Disorders, Overweight, Hypertension, CTCAEDeregulated Nutrient SensingOverweight and obese adults are at increased risk for morbidity and mortality associated with many acute and chronic medical conditions, including hypertension, dyslipidemia, coronary heart disease, diabetes mellitus, gallbladder disease, respiratory disease, some types of cancer, gout, and arthritis.9072680
Increased insulin level, No metabolic abnormalities, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPatients with CHD have hyperinsulinemia and subtle metabolic abnormalities related with insulin resistance even in absence of overt risk factors.9078598
ObesityDeregulated Nutrient SensingHowever, in contemporary children obesity is a stronger determinant of insulin level and insulin resistance than size at birth.9084971
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingIn adults low birthweight and thinness at birth are associated with increased risk of glucose intolerance and non-insulin-dependent diabetes mellitus.9084971
Glucose Intolerance (disease)Deregulated Nutrient SensingHypovitaminosis D may be a significant risk factor for glucose intolerance.9084975
Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingImpaired glucose tolerance resulting from insulin resistance in subjects with cirrhosis or diabetes mellitus is not affected by phlebotomy treatment.9088667
Glucose Intolerance (disease)Deregulated Nutrient SensingIncreased age, higher socioeconomic class, and higher WHR were proven to be independent risk factors for glucose intolerance in either area.9096979
deficiency aspects, Diabetes MellitusDeregulated Nutrient SensingIn patients with diabetes mellitus, poor image quality is frequently obtained with FDG-PET, due to relative or absolute insulin deficiency and peripheral insulin resistance.9106773
Weight Gain, DyslipidemiasDeregulated Nutrient SensingThe Trp64Arg mutation of the beta 3-adrenergic receptor (beta 3AR) is prevalent in several ethnic groups and is associated with weight gain, and some features of syndrome X such as insulin resistance and dyslipidaemia.9112025
Obesity, Visceral, Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingNevertheless, it is not known at present whether this mutation is associated with visceral obesity, which is an important risk factor for the development of hypertension, dyslipidaemia, insulin resistance, non-insulin-dependent diabetes mellitus, and atherosclerosis.9112025
Liver Cirrhosis, diabeticDeregulated Nutrient SensingSeveral studies have demonstrated that diabetic patients with cirrhosis require insulin treatment because of insulin resistance.9126802
Liver Cirrhosis, diabeticDeregulated Nutrient SensingThe aim of this study was to ascertain whether long-term treatment with silymarin is effective in reducing lipoperoxidation and insulin resistance in diabetic patients with cirrhosis.9126802
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia causes development of atherosclerosis in chronic hemodialysis patients.9132551
Disorder of soft tissue, Dyslipidemias, Blood Vessel, Amyloidosis, UremiaDeregulated Nutrient SensingIn uraemia, the rise of AGEs is even more marked than in diabetics and is associated with a variety of tissue disorders including vascular damage, dyslipidaemia, and beta 2-microglobulin amyloidosis.9132640
Fatty Liver, Increased insulin level, ObesityDeregulated Nutrient SensingPrevious reports have revealed that fatty liver involving obesity is closely related to insulin resistance or hyperinsulinemia in adulthood.9138179
Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingFrom the Insulin Resistance Atherosclerosis Study and the San Luis Valley Diabetes Study.9144749
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingPersons with non-insulin-dependent diabetes mellitus (NIDDM) are at increased risk for cardiovascular disease, partly due to concomitant worsening of traditional risk factors including dyslipidemia and hypertension.9144749
Coronary heart diseaseDeregulated Nutrient SensingAmong this sample of nondiabetic men, moderate drinkers had the lowest levels of fasting insulin resistance index and fasting insulin, consistent with lower levels of insulin resistance and thus lower risk for coronary heart disease.9149662
Primary malignant neoplasmDeregulated Nutrient SensingThese considerations rationalize many findings in animal and epidemiologic studies, and suggest that non-diabetic insulin resistance may be a significant cancer risk factor.9160283
AtherosclerosisDeregulated Nutrient SensingIncreased IGF activity associated with insulin resistance may also promote benign hyperplasias-most notably atherosclerosis.9160283
Coronary heart diseaseDeregulated Nutrient SensingThis study does not support the concept that insulin resistance is an early atherogenic risk factor in offspring at risk for coronary disease because of their family history.9160815
Hypertension, CTCAE, Infection, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThe screen revealed high rates of smoking and excessive drinking, of preventable infections and their sequelae, and of hypertension, insulin resistance, diabetes and renal disease.9161065
Metabolic Syndrome XDeregulated Nutrient SensingWe suggest that the sympathetic nervous system may be involved in the pathophysiology of the characteristic insulin resistance or metabolic cardiovascular syndrome in young men.9162435
Massive Osteolyses, Glycogen Storage Disease, Dyslipidemias, DiseaseDeregulated Nutrient SensingLiver glycogen storage diseases (GSD) are disorders associated with severe dyslipidaemia which can induce cell membrane alterations and possibly reduced cell deformability.9163069
Weight GainDeregulated Nutrient SensingHowever, it is unknown whether insulin secretion rises to compensate for insulin resistance or high insulin secretion promotes body weight gain and the development of insulin resistance.9166675
Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingThe triglyceride-lowering effects of omega-3 fats and HDL cholesterol-raising effects of exercise may be appropriate management for dyslipidemia in NIDDM.9167099
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe age-standardized prevalence of dyslipidaemia increased in each location between 1978 (n = 1197) and 1991 (n = 1748) with the prevalence of hypercholesterolaemia (> or = 5.5 mmol/l) increasing from 18% to 36% (P < 0.001), and that of hypertriglyceridaemia (> or = 2.0 mmol/l) increasing from 9% to 15% (P < 0.001) in the capital city, Apia.9169164
DyslipidemiasDeregulated Nutrient SensingCurrent levels of dyslipidaemia in Western Samoa are similar to those observed in developed Western populations, and are increasing rapidly.9169164
Antihypertensive AgentsDeregulated Nutrient SensingAmong the hypertensives, there was a 2.0- to 3.6-fold higher risk of having a clustering of the insulin-resistance associated cardiovascular risk factors compared with that of the normotensives.9169999
Hypertensive (finding)Deregulated Nutrient SensingAmong the hypertensive subjects in the highest quartile of fasting plasma insulin there was a six- to 12-fold increase in risk associated with having two or more insulin resistance-associated cardiovascular risk factors compared with the subjects in the lowest quartile.9169999
Breast Carcinoma, Hyperinsulinism, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWhile most examined conditions seemed unrelated to breast cancer risk, the association with late-onset diabetes is of special interest as it suggests a role of hyperinsulinaemia and insulin resistance in breast cancer promotion.9184190
TG gene, DyslipidemiasDeregulated Nutrient SensingHigh triglyceride (TG) and low HDL cholesterol (HDL-C) is the characteristic dyslipidemia seen in insulin-resistant subjects.9194762
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingIn conclusion, the present results showed that high TG-low HDL-C, the characteristic dyslipidemia seen in insulin-resistant subjects, was at least as powerful a predictor of IHD as isolated high LDL-C.9194762
Glucose Intolerance (disease)Deregulated Nutrient SensingIt is suggested that an increase in mean BMI to the levels in the Europid population will be associated with a substantial increase in glucose intolerance in Chinese people.9196645
HyperandrogenismDeregulated Nutrient SensingA useful test to determine insulin resistance in obese hyperandrogenic women].9196992
Coronary Arteriosclerosis, Myocardial Ischemia, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, we demonstrated frequent disturbances in glucose metabolism indicating insulin resistance in patients with ischemic heart disease without a history of diabetes, but we could not demonstrate a relation between these disturbances and degree of coronary atherosclerosis.9200389
Complications of Diabetes MellitusDeregulated Nutrient SensingPotential mechanisms for the relationship of higher complex levels and diabetic complications include an altered fibrinolytic response and/or insulin resistance.9201602
Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingThe diabetes or impaired glucose tolerance that occurs in most patients with pancreatic cancer is characterized by profound insulin resistance.9211494
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient Sensing[Prevalence of glucose intolerance, diabetes mellitus, and high serum insulin levels in a Japanese urban population].9212655
Increased insulin level, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAn epidemiological study was conducted to investigate the prevalence of diabetes mellitus, glucose intolerance and hyperinsulinemia in an urban population.9212655
Increased insulin levelDeregulated Nutrient SensingThis syndrome is characterized by a persistent state of insulin resistance and compensatory hyperinsulinemia that may be etiologically related to the four risk factors.9214569
Vascular Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingClustering of risk factors for cardiovascular disease related to insulin resistance may account for the increased incidence of vascular disease in these conditions and in non-diabetic subjects.9218152
Cardiac complication, Hypertension, CTCAEDeregulated Nutrient SensingInfluence of aging on progression of cardiovascular complications associated with insulin resistance in patients with essential hypertension.9220277
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingHyperinsulinemia or insulin resistance is suggested to play a role in the pathogenesis of hypertension and its target organ diseases.9220277
Cardiac Hypertrophy, Hypertensive (finding), Hypertension, CTCAE, AtherosclerosisDeregulated Nutrient SensingThese results suggest that aging decreases insulin sensitivity even in essential hypertensive subjects and that insulin resistance does not affect the progression of cardiac hypertrophy and atherosclerosis in elderly patients with essential hypertension.9220277
NEUROD1 wt AlleleDeregulated Nutrient SensingRenal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM.9222647
Diabetes MellitusDeregulated Nutrient SensingTo determine the influences of renal function and insulin resistance on plasma leptin concentrations, we measured plasma leptin concentrations and performed the euglycaemic hyperinsulinaemic clamp studies in 57 patients with non-insulin-dependent diabetes mellitus with a wide range of renal function.9222647
Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingComparison of bezafibrate and simvastatin in the treatment of dyslipidaemia in patients with NIDDM.9223394
DyslipidemiasDeregulated Nutrient SensingFibrates and HMG CoA reductase inhibitors are commonly used in the treatment of diabetic dyslipidaemia.9223394
Glucose Intolerance (disease), CirrhoticDeregulated Nutrient SensingGlucose intolerance is encountered in the majority of cirrhotic patients.9225841
Hypertriglyceridemia, Dyslipidemias, NEUROD1 wt AlleleDeregulated Nutrient SensingAcipimox, being widely prescribed for treating hypertriglyceridemia, is also used in NIDDM patients for their dyslipidemia.9229195
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingImpairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries.9231040
Weight GainDeregulated Nutrient SensingIn contrast, longitudinal studies in adults show that insulin sensitivity and low fasting insulin concentrations are associated with increased weight gain, whereas insulin resistance seems to protect against weight gain.9231660
DyslipidemiasDeregulated Nutrient SensingThe use of AAD, although clinically safe and without side effects, had no effect on the dyslipidemia in our group of CAPD patients.9237290
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients.9237784
Hypertension, CTCAE, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingAlthough insulin resistance has been involved in the pathogenesis of essential hypertension in non-diabetic patients, few studies were performed regarding to the association between insulin resistance, hypertension and nephropathy in diabetes mellitus.9240760
Diabetic Nephropathy, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingThese results suggest that insulin resistance is involved in the etiology of hypertension in NIDDM patients, and that this derangement has an important role for the progression of diabetic nephropathy.9240760
Coronary Artery DiseaseDeregulated Nutrient SensingIntra-abdominal fat, lipid metabolism and insulin resistance in coronary artery disease.9240769
Cardiovascular DiseasesDeregulated Nutrient SensingClinical impact of insulin resistance syndrome in cardiovascular diseases and its therapeutic approach.9240771
Coronary ArteriosclerosisDeregulated Nutrient SensingInsulin resistance significantly correlated with coronary atherosclerosis score.9240771
doxorubicin/procarbazine/vincristine protocolDeregulated Nutrient SensingInsulin resistance syndrome who fulfilled all the criteria was 9-10% for VAP.9240771
Increased insulin levelDeregulated Nutrient SensingIn atherothrombotic brain infarction (ATTI) with the same exclusion criteria, the similar insulin resistance and hyperinsulinemia have been observed, but not in embolic (cardiac origin) or lacunar infarction.9240771
Increased insulin level, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn essential hypertension without diabetes and obesity, hyperinsulinemia was noted in 25-35% and insulin resistance in 56-88%.9240771
Increased insulin levelDeregulated Nutrient SensingInsulin resistance rather than hyperinsulinemia is more closely associated with blood pressure.9240771
Cardiovascular Diseases, Diabetes Mellitus, Angina Pectoris, Variant, Arteriopathic diseaseDeregulated Nutrient SensingCardiovascular diseases (vasospastic and obstructive AP, brain cortical artery diseases) are prone to develop diabetes because of insulin resistance and also promote the generation of cumulative risk factors resulting in a vicious cycle.9240771
Cardiovascular DiseasesDeregulated Nutrient SensingEfforts to alleviate insulin resistance is crucial for the primary and secondary prevention of cardiovascular diseases.9240771
Cancer-related fatigue, HyperinsulinismDeregulated Nutrient SensingThis suggests that insulin resistance and hyperinsulinaemia contribute to elevated serum leptin concentrations in CRF.9249764
Cancer-related fatigue, Glucose Intolerance (disease)Deregulated Nutrient SensingConsequently, extremely elevated serum leptin may play a role in reducing glucose-stimulated insulin secretion and glucose intolerance in CRF.9249764
Diabetic Nephropathy, DyslipidemiasDeregulated Nutrient SensingRecent studies suggest that dyslipidaemia accelerates the progression of diabetic nephropathy, but the various pathomechanisms underlying such abnormalities are not completely delineated.9249767
Renal Insufficiency, Dyslipidemias, diabeticDeregulated Nutrient SensingWe isolated, radiolabelled, and characterized very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL) from eight diabetic patients with moderate impairment of renal function and dyslipidaemia and studied their interaction with LDL receptors in human glomerular epithelial cells.9249767
Fibrosis AssessmentDeregulated Nutrient SensingInsulin resistance with altered secretory kinetics and reduced proinsulin in cystic fibrosis patients.9252906
Congenital glucose-galactose malabsorptionDeregulated Nutrient SensingThe ratio of glucose to insulin, an indicator of insulin resistance, increased in CF patients with progression of carbohydrate intolerance.9252906
Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingIn CF patients with impaired glucose tolerance or diabetes, integrated insulin release is not diminished, indicating that insulin resistance is likely to contribute to hyperglycemia in CF patients with IGT or DM.9252906
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingThese data indicate that the Asp905Tyr polymorphism of the PP1 G subunit is not associated with essential hypertension, nor with insulin resistance and/or hyperinsulinemia in Japanese patients with essential hypertension, suggesting that the polymorphism plays little if any role in susceptibility to insulin resistance or hypertension.9260986
DyslipidemiasDeregulated Nutrient SensingThe risk associated with the apo E polymorphism is unrelated to dyslipidemia.9261250
Coronary Artery Disease, AtherosclerosisDeregulated Nutrient SensingInsulin resistance is known to be associated with atherosclerosis and coronary artery disease.9267146
Glucose Intolerance (disease), Coronary Artery DiseaseDeregulated Nutrient SensingThese data suggest that aging is associated with glucose intolerance, insulin resistance, and an increased risk of coronary artery disease, but that the effect of aging on coronary artery disease cannot be explained by insulin resistance alone.9267146
Glucose Intolerance (disease), Coronary Artery DiseaseDeregulated Nutrient SensingOther factors, such as glucose intolerance and increased blood pressure, in addition to insulin resistance, appear to be responsible of the increased risk for coronary artery disease in the elderly.9267146
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance and hyperinsulinemia have been linked to essential hypertension.9267147
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThese results indicate that 1) reduction in insulin sensitivity plays a role in age-related acceleration of hypertension and of glucose intolerance; 2) in patients with essential hypertension, selective insulin resistance with respect to glucose metabolism can be found even in those who are young; and 3) both sodium retention and pressor system activation via insulin might cause blood pressure to increase in patients with essential hypertension.9267147
Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingSome epidemiological studies showed that the prevalence of hypertension, glucose intolerance, and diabetes mellitus increase with advancing age.9267147
diabetic, NEUROD1 wt AlleleDeregulated Nutrient SensingMuscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients.9267990
NEUROD1 wt AlleleDeregulated Nutrient SensingThese findings indicate that the M416V mutation of the GYS1 gene is one of the factors contributing to the insulin resistance in the Japanese population and may play some role in the pathogenesis of NIDDM.9267990
Malignant Neoplasms, Diabetes Mellitus, Non-Insulin-Dependent, Syndrome, Cardiovascular DiseasesDeregulated Nutrient SensingFor example, occurrence of different cancers within pedigrees was suggestive of familial cancer syndromes, and clustering of noninsulin-dependent diabetes and cardiovascular disease suggested an insulin resistance syndrome.9268102
Increased insulin level, Cardiovascular DiseasesDeregulated Nutrient SensingThe authors conclude that a clustering of cardiovascular disease risk factors in nondiabetic subjects is not only associated with hyperinsulinemia but also with insulin resistance.9270410
Cushing SyndromeDeregulated Nutrient SensingAlthough it is well established that hypercortisolism causes insulin resistance, the mechanisms responsible for impaired insulin action in Cushing's syndrome are unclear.9274705
Cushing SyndromeDeregulated Nutrient SensingPatients with Cushing's syndrome show marked peripheral insulin resistance and enhanced hepatic G/G6P cycle activity.9274705
HyperinsulinismDeregulated Nutrient SensingDuring hyperinsulinaemia G/G6P cycle activity was increased but insulin resistance was predominantly due to reduced peripheral glucose uptake.9274705
NEUROD1 wt AlleleDeregulated Nutrient SensingResults thus suggest that acarbose improved insulin resistance in some patients with NIDDM (responders as classified by principal component analysis).9279483
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingEffect of acarbose on glucose intolerance in patients with non-insulin-dependent diabetes mellitus.9279483
Glucose Intolerance (disease), Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingWe evaluated the effect of acarbose, an alpha-glucosidase inhibitor, on glucose intolerance in patients with non-insulin-dependent diabetes mellitus (NIDDM).9279483
Increased insulin level, Glucose Intolerance (disease), Ovarian Hyperandrogenism, ObesityDeregulated Nutrient SensingOvarian hyperandrogenism can be associated with insulin resistance, hyperinsulinemia, glucose intolerance, and obesity.9284746
Diabetic Nephropathy, diabeticDeregulated Nutrient SensingInsulin resistance in non-obese, non-insulin-dependent diabetic patients with diabetic nephropathy.9284889
Diabetic Nephropathy, NEUROD1 wt AlleleDeregulated Nutrient SensingTo investigate the association between insulin resistance and diabetic nephropathy, peripheral insulin sensitivity indices (M/I values) were evaluated via euglycemic-hyperinsulinemic clamp in 45 non-obese, non-insulin-dependent diabetic (NIDDM) subjects.9284889
Microalbuminuria, Kidney Diseases, Obesity, Uremia, NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, the present cross-sectional study demonstrated in non-obese NIDDM patients with nephropathy that microalbuminuria did not affect peripheral insulin resistance, but uremia did, as in nondiabetic patients, and that the peripheral insulin resistance was significantly contributed to by the degree of obesity and uremia.9284889
NEUROD1 wt AlleleDeregulated Nutrient SensingWhole body insulin resistance characterizes patients with NIDDM, but it is not known whether insulin also has impaired ability to stimulate myocardial glucose uptake (MGU) in these patients.9287051
NEUROD1 wt AlleleDeregulated Nutrient SensingAs studied by [18F]FDG PET under stable normoglycemic hyperinsulinemic conditions, MGU is not reduced in patients with NIDDM and CAD in spite of peripheral insulin resistance.9287051
Vascular Diseases, Hypertriglyceridemia, HyperinsulinismDeregulated Nutrient SensingBoth hyperinsulinaemia and insulin resistance are associated with fasting hypertriglyceridaemia and both increased VLDL production and increased plasma triglyceride concentrations commonly occur in association with abnormal glucose tolerance and atheromatous vascular disease.9288540
Vascular DiseasesDeregulated Nutrient SensingWe suggest that abnormal NEFA suppression plays an important part in the increase in risk of vascular disease associated with insulin resistance.9288540
Microalbuminuria, Peripheral Vascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Diabetic NephropathyDeregulated Nutrient SensingIt is concluded that microalbuminuria in Type 2 diabetes reflects both the existence of diabetic nephropathy and peripheral vascular disease which is often associated with the insulin resistance syndrome.9288546
NEUROD1 wt AlleleDeregulated Nutrient SensingOur data suggest that a high plasma NEFA concentration is a risk marker for deterioration of glucose tolerance independent of the insulin resistance or the insulin secretion defect that characterize subjects at risk for NIDDM.9300248
Sialorrhea, ObesityDeregulated Nutrient SensingInsulin resistance and insulin hypersecretion are established features of obesity.9303923
Obesity, AbdominalDeregulated Nutrient SensingIn nondiabetic, normotensive obese subjects, the prevalence of insulin resistance is relatively low, and is exceeded by the prevalence of insulin hypersecretion, particularly in women with central obesity.9303923
Chronic glomerulonephritis, DyslipidemiasDeregulated Nutrient SensingIn the more homogeneous subgroup of patients with chronic glomerulonephritis the association between dyslipidaemia and the rate of progression was even more pronounced.9306342
Increased insulin level, Glucose Intolerance (disease), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingInsulin resistance has been hypothesized to unify the clustering of hypertension, glucose intolerance, hyperinsulinemia, increased levels of triglyceride and decreased HDL cholesterol, and central and overall obesity.9313755
Increased insulin levelDeregulated Nutrient SensingInsulin resistance (reflected by hyperinsulinemia) alone did not appear to underlie all features of the insulin resistance syndrome.9313755
Glucose Intolerance (disease), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingGlucose intolerance and hypertension were linked to the central syndrome through shared correlations with insulin levels and obesity.9313755
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingGlucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality.9322802
Chronic diseaseDeregulated Nutrient SensingJapanese individuals living outside Japan are more susceptible to chronic diseases included in the insulin resistance syndrome.9322996
Increased insulin level, Glucose Intolerance (disease), OverweightDeregulated Nutrient SensingThe association of overweight, hyperinsulinemia, glucose intolerance, and high blood pressure can be detected early, but the significance of these findings would be better explained by longitudinal studies.9322998
ObesityDeregulated Nutrient SensingRaised serum urate appears to be an integral part of the cluster of risk factors associated with the insulin resistance syndrome that include obesity, raised serum triglycerides, and serum cholesterol.9326988
HypertriglyceridemiaDeregulated Nutrient SensingGemfibrozil treatment of hypertriglyceridemia: improvement on fibrinolysis without change of insulin resistance.9327717
Hepatobiliary Disorder, Glucose Intolerance (disease)Deregulated Nutrient SensingLiver disease is accompanied by "insulin resistance" of glucose metabolism, whereby glucose intolerance occurs despite relatively increased plasma insulin concentration.9346691
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThis study shows that in Vietnamese people, essential hypertension is associated with a significant increase in BMI, which however remains far lower than the definition threshold of occidental obesity and with a state of insulin resistance found despite very slight or no excess weight.9347408
Hypertensive (finding)Deregulated Nutrient SensingIt is concluded that moderate salt restriction seems not to adversely influence insulin resistance or serum lipids in hypertensive patients.9350069
Hypertension, CTCAEDeregulated Nutrient SensingEarly insulin-secretion abnormalities may be the very first step towards the development of insulin resistance and an important factor initiating the hypertension in hypertension-prone individuals.9350591
Increased insulin level, Atherosclerosis, Congenital AbnormalityDeregulated Nutrient SensingIt has been suggested that insulin resistance and consequent hyperinsulinemia promote atherosclerosis, but few prospective studies have reported the relationships between hyperinsulinemia and the development of ST-T abnormalities in the 12-lead resting electrocardiogram (ECG) in populations in which atherosclerosis is rare.9353609
Increased insulin level, Glucose Intolerance (disease), Congenital Abnormality, AtherosclerosisDeregulated Nutrient SensingHyperinsulinemia was related to the development of ST-T abnormalities in ECGs in the absence of the development of clinical signs of atherosclerosis, independent of blood pressure and other risk factors in men and women with mild glucose intolerance.9353609
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThe fact that significant metabolic improvement was seen in the obese nondiabetic hyperinsulinemic women studied suggests that Ergoset could be of therapeutic benefit in clinical conditions of hyperglycemia and/or dyslipidemia.9353611
Arteriosclerosis Obliterans, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance and arteriosclerosis obliterans in patients with NIDDM.9353618
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe chromium requirement is postulated to increase with increased glucose intolerance and diabetes.9356027
AtherosclerosisDeregulated Nutrient SensingInsulin sensitivity and intake of vitamins E and C in African American, Hispanic, and non-Hispanic white men and women: the Insulin Resistance and Atherosclerosis Study (IRAS).9356542
Atherosclerosis, Diabetes Mellitus, Obesity, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingElevated fasting insulin concentrations and insulin resistance have been associated with non-insulin-dependent diabetes mellitus (NIDDM), obesity, atherosclerosis, and hypertension.9356542
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCigarette smoking and insulin resistance in patients with noninsulin-dependent diabetes mellitus.9360516
NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, chronic cigarette smoking seems to markedly aggravate insulin resistance in patients with NIDDM.9360516
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingThus, a low Mg concentration in nondiabetic subjects was associated with relative insulin resistance, glucose intolerance, and hyperinsulinemia.9360541
Increased insulin level, Hypertension, CTCAE, Diabetes Mellitus, Coronary heart diseaseDeregulated Nutrient SensingHyperinsulinemia is associated with insulin resistance and with the development of diabetes, hypertension, and coronary heart disease.9361683
Skeletal muscle weaknessDeregulated Nutrient SensingThe findings suggest that skeletal muscle weakness may precede and predict the development of insulin resistance, and raise the intriguing possibility of some common cause in skeletal muscle pathophysiology.9361683
Glucose Intolerance (disease), Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingThere was a progressive increase with age in the prevalence of glucose intolerance, hypertension, dyslipidaemia and obesity.9363738
Adenoma, Carcinoma, Glucose Intolerance (disease)Deregulated Nutrient SensingThere was a trend toward increased incidence of glucose intolerance among carcinoma patients but no significant differences in clinical signs or symptoms between adenoma and carcinoma patients could be made.9366310
Alzheimers DiseaseDeregulated Nutrient SensingAssociation between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study.9366728
Alzheimers DiseaseDeregulated Nutrient SensingTo determine the association between features of the insulin resistance syndrome and Alzheimer's disease.9366728
Alzheimers DiseaseDeregulated Nutrient SensingPresence of features of the insulin resistance syndrome and diagnosis of Alzheimer's disease by detailed neurological and neuropsychological evaluation.9366728
Alzheimers DiseaseDeregulated Nutrient SensingFeatures of the insulin resistance syndrome are associated with Alzheimer's disease independently of apolipoprotein E4 phenotype.9366728
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingCox models were used to adjust for age, sex, smoking, glucose intolerance, total cholesterol, and prior cardiovascular disease.9369249
Increased insulin level, ObesityDeregulated Nutrient SensingInsulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity.9369268
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is thought to be a pathogenetic factor, predisposing genetically prone individuals to develop the microvascular complications of diabetes.9371478
Glucose Intolerance (disease), Kidney Diseases, diabeticDeregulated Nutrient SensingWe conclude that offspring of diabetic parents with nephropathy do not show higher risk of glucose intolerance or insulin resistance compared to those with diabetic parents without nephropathy.9371478
diabeticDeregulated Nutrient SensingThe relatively high plasma glucose values in the presence of normal insulin secretion in both groups of offspring of diabetic parents suggest the presence of insulin resistance.9371478
Glucose Intolerance (disease)Deregulated Nutrient SensingIncreased prednisolone dose and older age are strongly associated with the development of posttransplant glucose intolerance.9381545
Glucose Intolerance (disease), Hypertriglyceridemia, Obesity, Diabetes MellitusDeregulated Nutrient SensingEach one of the three diets was offered ad libitum to adult rats of line IIMb/Fm beta (beta), affected by obesity, hypertriglyceridemia and glucose intolerance or diabetes.9382678
TG gene, DyslipidemiasDeregulated Nutrient SensingOur data suggest that the polymorphisms at the LPL gene, as the linkage markers with an aetiologic mutation at or around LPL gene, may constitute one of the genetic determinants for the population variation in plasma TG levels, as well as for the common dyslipidemia in Chinese populations.9387400
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingImpaired glycogen synthesis after insulin stimulation accounts for most of the insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM).9389424
NEUROD1 wt Allele, diabeticDeregulated Nutrient SensingIn conclusion, the new Gln71His and Met416Val substitutions and other variants of the glycogen synthase gene are unlikely to make a major contribution to insulin resistance and NIDDM in diabetic patients from eastern Finland.9389424
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingNon-insulin-dependent diabetes mellitus (NIDDM) is caused by peripheral insulin resistance and impaired beta cell function.9389749
CDISC SDTM Immunogenicity Specimen Assessments Test Name TerminologyDeregulated Nutrient SensingThe IST showed marked insulin resistance in both parents and the older, homozygous son, and moderate resistance in the younger son.9389749
Weight Gain, NEUROD1 wt Allele, Increase in blood pressureDeregulated Nutrient SensingWe reached the following conclusions: 1) after an initial good response, glycemic control deteriorates more in obese than in nonobese patients with NIDDM; 2) in obese patients, weight gain per se cannot explain the poor glycemic response to combination or insulin therapy, but it may induce a disproportionately large increase in insulin requirements because of greater insulin resistance in the obese than in the nonobese; 3) in nonobese patients, glycemic control improves equally during 1 yr with combination therapy with insulin and insulin alone, but combination therapy with insulin is associated with less weight gain than treatment with insulin alone; 4) weight gain appears harmful, as it is associated with increases in blood pressure and low density lipoprotein cholesterol.9398709
Hypertension, CTCAEDeregulated Nutrient Sensing[Insulin resistance and essential hypertension in Vietnamese subjects].9404424
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingSeveral epidemiological and experimental studies suggest that essential arterial hypertension is associated with hyperinsulinism and insulin resistance in obese subjects and also in subjects with normal body weight.9404424
Hypertensive (finding)Deregulated Nutrient SensingThe aim of this study was to look for insulin resistance in hypertensive Vietnamese subjects, despite a markedly lower BMI in Vietnam than in occidental countries.9404424
Hypertensive (finding)Deregulated Nutrient SensingThus, despite under-nutrition, hypertensive Vietnamese patients have a moderate but significant increase in BMI and fat mass without predominant abdominal localization, and a state of insulin-resistance, compared with normotensive healthy subjects.9404424
Beta-cell dysfunction, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingIn the Korean population, beta-cell dysfunction, as measured by high proinsulin levels, seems to be associated with subsequent development of NIDDM, whereas regional and general obesity and fasting insulin levels, which may be a surrogate for insulin resistance, were not.9405904
Coronary heart diseaseDeregulated Nutrient SensingRelation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians.9409247
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSmall, dense LDL has been shown to be associated with the insulin resistance syndrome and coronary heart disease (CHD).9409247
Thickened, Angina Pectoris, VariantDeregulated Nutrient SensingInsulin resistance as an independent risk factor for carotid artery wall intima media thickening in vasospastic angina.9409326
Increased insulin level, Coronary Artery Disease, Angina Pectoris, VariantDeregulated Nutrient SensingStudies have shown the presence of insulin resistance together with compensatory hyperinsulinemia in vasospastic angina as well as obstructive coronary artery disease.9409326
Dental Plaque, Angina Pectoris, VariantDeregulated Nutrient SensingThe patients with vasospastic angina showed a significant increase in the average intima media thickness of the carotid wall and frequency of plaque formation, although they were comparable to the control subjects in risk factors other than insulin resistance.9409326
Increased insulin level, Coronary Artery Vasospasm, AtherosclerosisDeregulated Nutrient SensingThese results suggest that insulin resistance in association with compensatory hyperinsulinemia may be an important pathogenic factor for the development of coronary artery spasms and systemic early atherosclerosis.9409326
Hypertensive (finding), NEUROD1 wt AlleleDeregulated Nutrient SensingThese findings indicate that, in hypertensive patients with NIDDM, ie, in subjects who have established insulin resistance, treatment with nebivolol and atenolol neither further deteriorated insulin sensitivity nor adversely affected the lipid profile.9416986
Hyperglycemia, NEUROD1 wt AlleleDeregulated Nutrient SensingHyperglycemia rather than insulin resistance is related to reduced coronary flow reserve in NIDDM.9421384
Hyperglycemia, NEUROD1 wt AlleleDeregulated Nutrient SensingTo clarify if coronary flow reserve (CFR) is related to insulin resistance or hyperglycemia in normotensive NIDDM, myocardial blood flow (MBF) at baseline and during dipyridamole loading were measured with 13N-ammonia positron-emission tomography.9421384
NEUROD1 wt AlleleDeregulated Nutrient SensingCFR in patients with well-controlled NIDDM was significantly higher than in those with poorly controlled NIDDM, whereas insulin resistance was comparable between the two groups.9421384
NEUROD1 wt AlleleDeregulated Nutrient SensingCFR in NIDDM patients was not related to the degree of insulin resistance.9421384
NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, control of blood glucose concentration rather than insulin resistance is most likely related to the reduced CFR in NIDDM.9421384
Hyperlipidemia, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThis is caused, at least in part, by a higher prevalence of obesity-related coronary risk factors such as hyperlipidemia, hypertension, sedentary lifestyle, insulin resistance, and diabetes.9421764
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingFurther studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes.9425261
Chronic liver disease, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance and diabetes mellitus are both prevalent in patients with chronic liver diseases.9430016
Hypertensive (finding)Deregulated Nutrient SensingNaCl sensitivity of essential hypertensive patients is related to insulin resistance.9431856
HyperinsulinismDeregulated Nutrient SensingInsulin resistance was not associated with overt hyperinsulinaemia among these patients.9431856
Hypertensive (finding), Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingTo evaluate insulin sensitivity of essential hypertensive patients with different salt sensitivities of blood pressure in the absence of confounding factors such as obesity, glucose intolerance and the inclusion both of normotensive and of hypertensive subjects that have affected most previous studies.9431856
Hypertensive (finding), Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThis study showed that essential hypertensive patients with high NaCl sensitivities were relatively insulin resistant compared with those with low NaCl sensitivities, independently of confounding factors such as age, obesity and glucose intolerance.9431856
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAdditional therapy for hypertension and dyslipidemia was started if necessary.9439556
ObesityDeregulated Nutrient SensingLow levels of DHA and other LCPUFAs in skeletal muscle membrane phospholipid are associated with insulin resistance and obesity in adults.9440487
DiseaseDeregulated Nutrient SensingEarly changes in skeletal muscle membrane phospholipid FA saturation may play a role in the subsequent development of diseases associated with insulin resistance.9440487
Increased insulin levelDeregulated Nutrient SensingPrevious work in younger males with recurrent idiopathic calcium urolithiasis (RCU) demonstrated inappropriately high postprandial phosphaturia, hyperinsulinemia and insulin resistance, but normal glycemia.9443652
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingIntensive risk factor reduction in patients with dyslipidemias and coronary atherosclerosis has been shown to result in alterations in coronary artery morphology and reduced clinical events.9444880
Dyslipidemias, diabeticDeregulated Nutrient SensingThe data suggest that pravastatin is effective and safe in the treatment of dyslipidemia in both type-1 and type-2 diabetic patients.9451475
NEUROD1 wt AlleleDeregulated Nutrient SensingResults show that expression of hybrids is increased in fat of NIDDM patients compared to control subjects and is correlated with in vivo insulin sensitivity thus raising the possibility that alterations in expression of hybrids which bind IGF-I with higher affinity than insulin may contribute, at least in part, to insulin resistance.9453239
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe results suggest that celiprolol improves insulin sensitivity of hypertensive patients with dyslipidemia in long-term therapy.9456288
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingIn conclusion, the results indicate that, in microalbuminuric NIDDM patients, effective treatment of dyslipidaemia could be associated with stabilization of urinary albumin excretion.9466127
Hypertension, CTCAEDeregulated Nutrient SensingRecent retrospective studies of older adults have demonstrated a correlation between lower birth weight and hypertension and insulin resistance.9470007
Coronary Artery DiseaseDeregulated Nutrient Sensing'True' fasting serum insulin level, insulin resistance syndrome and coronary artery disease.9472456
Hypoglycemia, AtherosclerosisDeregulated Nutrient SensingIncreased fasting serum insulin level not associated with hypoglycemia is considered to be a practical indicator of the insulin resistance syndrome, a frequent risk factor for atherosclerosis in industrialized countries.9472456
Apolipoproteins B, Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, ObesityDeregulated Nutrient SensingThere was a significant correlation between elevated 'true' fasting serum insulin level and various constituents of the insulin resistance syndrome, such as obesity, dyslipidemia (hypertriglyceridemia, increased apolipoprotein B and decreased high-density lipoprotein cholesterol and apolipoprotein A1 concentrations), increased serum glucose, uric acid levels, and plasminogen activator inhibitor type I concentration, as well as increased frequency of diabetes.9472456
Coronary Artery DiseaseDeregulated Nutrient SensingAn increase of 'true' fasting serum insulin level is a useful practical index to identify patients with the insulin resistance syndrome exposed to increased risk of coronary artery disease.9472456
Myocardial IschemiaDeregulated Nutrient SensingInsulin resistance has been related to the pathogenesis and development of ischemic heart disease (IHD).9479557
Myocardial IschemiaDeregulated Nutrient SensingThe aim of this study was to clarify the relationship between insulin resistance and DHEA-S in patients with IHD.9479557
Myocardial IschemiaDeregulated Nutrient SensingInsulin resistance, defined as an insulin sensitivity index (ISI) below the normal range derived from the control group, was present in 78% of IHD patients; they also displayed, as a group, lower ISI (P < 0.0001) than controls.9479557
No metabolic abnormalities, Myocardial IschemiaDeregulated Nutrient SensingIn conclusion, insulin sensitivity is lower in patients with IHD, even when major metabolic abnormalities associated with insulin resistance are excluded.9479557
Proteinuria, Hypercholesterolemia, Glucose Intolerance (disease)Deregulated Nutrient SensingFemale prevalence rates of glucose intolerance, hypercholesterolemia and proteinuria were significantly higher in 25-27 BMI than in 23-25.9483954
Diabetes MellitusDeregulated Nutrient SensingCross-sectional measurements at age 70 showed that high 24-hour BP, nondipping, insulin resistance, and diabetes all were related to low cognitive function.9495261
Metabolic Syndrome XDeregulated Nutrient SensingReduced peripheral sensitivity to insulin-stimulated glucose disposal, insulin resistance, is considered to be central in the metabolic cardiovascular syndrome.9495639
AtherosclerosisDeregulated Nutrient SensingIntensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study.9496984
AtherosclerosisDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study, conducted in Oakland, Calif; Los Angeles, Calif; the San Luis Valley, Colo; and San Antonio, Tex.9496984
Glucose Intolerance (disease), HypertriglyceridemiaDeregulated Nutrient SensingHypertriglyceridaemia is associated with glucose intolerance and insulin resistance.9502184
Dyslipidemias, Vascular Diseases, Hypertension, CTCAE, atheroscleroticDeregulated Nutrient SensingWe can confirm that hypertension and dyslipidaemia, which are two of the main risk factors for vascular diseases on an atherosclerotic basis, are often associated.9504350
Acute myocardial infarctionDeregulated Nutrient SensingDyslipidemias have a detrimental effect on left ventricular systolic function in patients with a first acute myocardial infarction.9514445
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingCategorical definitions for glucose intolerance imply that risk thresholds exist, but metabolic risk for type 2 diabetes mellitus or cardiovascular disease may increase continuously as glucose intolerance increases.9518396
Increased insulin level, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingInsulin resistance or compensatory hyperinsulinemia has been associated with hypertension and dyslipidemia in cross-sectional studies.9519724
Increased insulin level, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men.9519724
Increased insulin level, Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingThese findings demonstrate the role of hyperinsulinemia in incident hypertension and dyslipidemia and suggest that both hypertension and dyslipidemia are associated with insulin metabolism disturbance, independently of obesity and body weight.9519724
diabeticDeregulated Nutrient SensingFactors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men.9525530
Diabetes MellitusDeregulated Nutrient SensingThese consistently identified composite factors may represent markers for underlying pathophysiologic mechanisms of the insulin resistance syndrome and risk of non-insulin-dependent diabetes mellitus.9525530
Glucose Intolerance (disease), Hypertension, CTCAE, OverweightDeregulated Nutrient SensingHypertension is no longer rare in Alaska Natives and is associated with overweight, non-indigenous diet, mechanized activities, and glucose intolerance.9526689
Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingTo study the regulation of the interstitial glucose concentration in skeletal muscle, nine control subjects and nine older and overweight non-insulin-dependent diabetes mellitus (NIDDM) subjects with extreme insulin resistance were investigated with microdialysis in the medial femoral muscle before and during a euglycemic insulin clamp.9530127
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle.9535149
Hypertension, CTCAEDeregulated Nutrient SensingThe association between hypertension and insulin resistance might be explained by increased activity of the principal glucocorticoid, cortisol.9535410
Hypertension, CTCAEDeregulated Nutrient SensingIn this report, we examine whether increased glucocorticoid sensitivity or secretion is associated with insulin resistance and is a cause or consequence of hypertension.9535410
Hyperglycemia, Hypertension, CTCAEDeregulated Nutrient SensingIn both populations, increased dermal glucocorticoid sensitivity was associated with relative hypertension, insulin resistance, and hyperglycemia.9535410
Hypertension, CTCAEDeregulated Nutrient SensingIt may be mediated by an abnormal glucocorticoid receptor, and it may contribute to the association between hypertension and insulin resistance.9535410
Acromegaly, Diabetic KetoacidosisDeregulated Nutrient SensingAcromegaly in a woman presenting with diabetic ketoacidosis and insulin resistance.9536592
AcromegalyDeregulated Nutrient SensingAcromegaly should be considered in the differential diagnosis of unexplained insulin resistance.9536592
Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSusceptibility to insulin resistance in Arabian peninsula men is strongly supported, suggesting that control of obesity and promotion of exercise are the best approach to CHD prevention.9537269
Hyperlipidemia, Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingFamilial combined hyperlipidaemia (FCHL) represents the most common genetic dyslipidemia with a prevalence of 1.0-2.0%.9537421
ObesityDeregulated Nutrient SensingThese specific assays for insulin indicate that after adjusting for obesity nondiabetic Pima Indians are truly hyperinsulinemic, which is consistent with their insulin resistance as measured by other methods.9538983
Irregular Menstruation, Increased insulin level, Diabetes Mellitus, HyperandrogenismDeregulated Nutrient SensingThis association may be because of insulin resistance and hyperinsulinemia, which predict type 2 diabetes, also causing hyperandrogenism and menstrual irregularity.9540014
deficiency aspects, Glucose Intolerance (disease), Obesity, Diabetes MellitusDeregulated Nutrient SensingWe speculate that the rise in Type 2 diabetes in Indian urban populations may have been triggered by mild obesity in mothers, leading to glucose intolerance during pregnancy, macrosomic changes in the fetus, and insulin deficiency in adult life.9545123
NEUROD1 wt AlleleDeregulated Nutrient SensingPioglitazone (AD-4833) ameliorates insulin resistance in patients with NIDDM.9550126
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingBoth insulin resistance and abdominal fat patterning are related to aging, and have been related to cardiovascular disease (CVD) risk factors such as dyslipidemia and hypertension.9550536
Inflammation, Thrombophilia, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingFactor VII coagulant activity (VIIc) and hypercoagulability in chronic renal disease and dialysis: relationship with dyslipidaemia, inflammation, and factor VII genotype.9550647
Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingA persistent inflammatory response and the dyslipidaemia of renal disease may contribute to coagulation activation and increased cardiovascular risk.9550647
Increased insulin levelDeregulated Nutrient SensingThese clinical features were compatible with leprechaunism; however, the absence of hyperinsulinemia and insulin resistance prevented the diagnosis of leprechaunism.9560023
Diabetes MellitusDeregulated Nutrient SensingIn addition, analytical data point to a possible contribution of excessive hepatic glucose production to the pathogenesis of the insulin resistance in non-insulin-dependent diabetes mellitus.9560529
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance, dehydroepiandrosterone sulfate and sex hormone-binding globulin in essential hypertension.9566859
CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology, Hypertensive (finding)Deregulated Nutrient SensingIn 15 non-treated hypertensive patients, insulin resistance was measured by an insulin suppression test (IST).9566859
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingDisorders in lipid metabolism (dyslipidemia) can result to the chronic heart disease.9567502
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent, Kidney DiseasesDeregulated Nutrient SensingIn type 2 diabetes, CAD is likely to be linked with the insulin resistance associated with the type 2 "process," while CAD in type 1 diabetes has, so far, been more closely linked to renal disease.9571351
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingBecause the etiologies of type 1 and type 2 diabetes are different, it is possible that some CAD in type 1 diabetes may be related to the coexistence of type 2 diabetes susceptibility (i.e., insulin resistance).9571351
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingThis supports the concept that insulin resistance may contribute to development of CAD in type 1 diabetes.9571351
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Diabetes Mellitus, Non-Insulin-Dependent, Arteriopathic diseaseDeregulated Nutrient SensingImproving dyslipidemia in type 2 diabetic subjects had no effect on the progress of ultrasonically measured arterial disease, although the lower rate of "definite CHD events" in the treated group suggests that this might result in a reduction in the incidence of coronary heart disease.9571357
HD Term Type, Glucose Intolerance (disease), Hypertriglyceridemia, Hypoinsulinaemia (disorder)Deregulated Nutrient SensingThus, intravenous 1,25(OH)2D3 therapy corrected glucose intolerance, insulin resistance, hypoinsulinemia as well as hypertriglyceridemia in patients on HD, in the absence of PTH suppression.9573552
ObesityDeregulated Nutrient SensingImpaired stimulation of glucose metabolism and reduced suppression of lipolytic activity have both been suggested as important defects related to the insulin resistance of adolescent obesity.9575836
ObesityDeregulated Nutrient SensingObesity type and clustering of insulin resistance-associated cardiovascular risk factors in middle-aged men and women.9578244
ObesityDeregulated Nutrient SensingTo examine different clusterings of the insulin resistance-associated cardiovascular risk factors with respect to different types of obesity.9578244
Hypertriglyceridemia, Hyperinsulinism, Dyslipidemias, ObesityDeregulated Nutrient SensingThe prevalence of a cluster consisting of dyslipidaemia (hypertriglyceridaemia and/or low HDL-cholesterol) and insulin resistance (abnormal glucose metabolism and/or hyperinsulinaemia) was found to be 4% in the control subjects, 18% in the abdominal adipose subjects (WHR > or = 1.00 in men and > or = 0.88 in women with a BMI < 30 kg/m2), 28% in the 'pure' obese subjects (BMI> or = 30 kg/m2 with WHR < 1.00 in men and < 0.88 in women), and 46% in the central obese subjects (subjects showing both 'pure' obesity and abdominal adiposity).9578244
ObesityDeregulated Nutrient SensingClusterings of insulin resistance-associated abnormalities were related to the type of obesity in both middle-aged men and middle-aged women.9578244
Glucose Intolerance (disease)Deregulated Nutrient SensingThere was no evidence of tachyphylaxis or evidence to suggest development of glucose intolerance.9578821
Diabetes MellitusDeregulated Nutrient SensingWe conclude that in transgenic mice expressing hIAPP, insulin resistance can induce overt, slow-onset diabetes associated with islet amyloid and decreased beta-cell mass.9588445
Obesity, Diabetes MellitusDeregulated Nutrient SensingFirst-degree family history of diabetes may confer insulin resistance that is independent of obesity.9588451
Microalbuminuria, AtherosclerosisDeregulated Nutrient SensingMicroalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study.9588452
Microalbuminuria, Hyperglycemia, NEUROD1 wt AlleleDeregulated Nutrient SensingHowever, the relationship between insulin resistance and microalbuminuria in patients with NIDDM could be due to hyperglycemia, which can cause both insulin resistance and an increase in albumin excretion rate.9588452
MicroalbuminuriaDeregulated Nutrient SensingLittle is known about microalbuminuria and insulin resistance in nondiabetic subjects.9588452
Microalbuminuria, ObesityDeregulated Nutrient SensingOur results suggest a relationship between insulin resistance and microalbuminuria in nondiabetic subjects that is partially dependent on blood pressure, glucose levels, and obesity.9588452
Fatty Liver, SteatohepatitisDeregulated Nutrient SensingWe hypothesized that elevated GGT levels are a marker for visceral fat, and specifically for hepatic steatosis (fatty liver), and that hepatic steatosis leads to hepatic insulin resistance.9589232
NEUROD1 wt AlleleDeregulated Nutrient SensingA reduced capacity to deposit and/or conserve LBF may be an independent factor associated with (or may be a marker of) the metabolic manifestations of the insulin resistance syndrome in women with NIDDM.9589249
AVP gene, Diabetes MellitusDeregulated Nutrient SensingHer case was complicated by non-insulin-dependent diabetes mellitus with severe insulin resistance, central diabetes insipidus, and hyposecretion of GH.9589656
HyperuricemiaDeregulated Nutrient SensingRelations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study.9590604
Obesity, Abdominal, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThe Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR) has been linked to earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), insulin resistance, abdominal obesity, and an increased capacity to gain weight in some European and Japanese populations.9591756
DiseaseDeregulated Nutrient SensingPlasma ACE levels, but not ACE genotype, correlated with lipids, plasma glucose, and blood pressure, suggesting that elevated plasma ACE levels may contribute to the link between insulin resistance and CAD disease or may be a consequence of it.9591757
Hypertension, CTCAE, Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance was higher in essential hypertension than in coronary heart disease.9594141
Hypertension, CTCAE, Coronary heart diseaseDeregulated Nutrient SensingIt is suggested that the interaction between insulin resistance and angiotensin II and endothelins might be involved in the development of essential hypertension and coronary heart disease.9594141
Diabetes Mellitus, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingTo evaluate whether a structural defect in the human glucose transporter gene GLUT1 could be involved in the aetiology of insulin resistance, a key factor of non-insulin-dependent diabetes mellitus (NIDDM) and obesity, we performed single-strand conformation polymorphism (SSCP) analysis in 40 subjects (20 NIDDM patients and 20 subjects with familial obesity).9600248
Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes in Mexicans was high and it may be related to a genetic susceptibility for an insulin resistance syndrome.9608783
HyperglycemiaDeregulated Nutrient SensingHyperglycaemia due to insulin resistance caused by interferon-gamma.9609368
HyperglycemiaDeregulated Nutrient SensingThe injection of IFN-gamma may cause hyperglycaemia because of insulin resistance, rather than beta-cell injury.9609368
Hypertensive (finding), Atherosclerosis, Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingOf 5,284 residents studied from 1993 to 1994 the prevalence of risk factors of atherosclerosis such as obesity, disorders of lipid metabolism and glucose intolerance were higher in hypertensive who were normotensive due to antihypertensive drugs than in the non-hypertensive residents.9611991
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingPrevalences of type 2 diabetes, the insulin resistance syndrome, and coronary heart disease in an elderly, biethnic population.9614614
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo compare the prevalences of type 2 diabetes, the various cardiovascular risk factors encompassing the insulin resistance syndrome (IRS), and coronary heart disease (CHD) in elderly Hispanics compared with non-Hispanic whites.9614614
Microalbuminuria, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPrevalences of total and central obesity, dyslipidemia, hypertension, and microalbuminuria also were determined.9614614
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe higher prevalences of dyslipidemia in Hispanics could be explained by a higher prevalence of diabetes.9614614
DyslipidemiasDeregulated Nutrient SensingThese findings suggest that PTH does not play a significant role in the dyslipidemia of renal failure.9617494
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingChildhood obesity increases the risk of obesity in adulthood and is associated with cardiovascular disease (CVD) risk factors such as hypertension, diabetes mellitus, and dyslipidemia.9625086
Cardiovascular morbidity, Diabetes MellitusDeregulated Nutrient SensingMarkers of insulin resistance are associated with cardiovascular morbidity and predict overall mortality in long-standing non-insulin-dependent diabetes mellitus.9625290
Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThese data indicate that in patients with long-standing type 2 diabetes mellitus and poor metabolic control, CHD and overall mortality are related to insulin release and to insulin administration, suggesting that markers of insulin resistance represent additional risk factors for CHD and for mortality.9625290
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingReduction of insulin resistance, together with achievement of good metabolic control, might prevent morbidity and mortality in long-standing type 2 diabetes mellitus.9625290
Ovarian HyperandrogenismDeregulated Nutrient SensingOvarian hyperandrogenism is associated with insulin resistance to both peripheral carbohydrate and whole-body protein metabolism in postpubertal young females: a metabolic study.9626116
ObesityDeregulated Nutrient SensingWe conclude that obesity in young postpubertal females is associated with insulin resistance for both peripheral carbohydrate and protein metabolism, and that patients with the OH syndrome have even greater insulin resistance as compared with simple obesity, regardless of treatment for the androgen excess.9626116
Increased insulin level, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus.9631870
Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingBecause the changes were observed to be associated with insulin resistance and type 2 diabetes mellitus, they may be modifiable by reduction of insulin resistance with insulin sensitizers and stringent control of hyperglycemia.9631870
Dyslipidemias, ObesityDeregulated Nutrient SensingThe association of obesity and dyslipidemia, namely high triglycerides and low HDL-cholesterol levels, is well known, but, as far as we are aware, the possible influence of obesity on the efficacy of current hypolipidemic drugs has never been studied.9632956
TG geneDeregulated Nutrient SensingThis simple assay for in vivo detection of LDL-LPO, emphasises the possible atherogenic effect of TG through their oxidative capacity and suggests the integration of LPO to the cluster of associated risk factors: high TG, low HDL-C and insulin resistance.9634641
Increased insulin levelDeregulated Nutrient SensingAs a result of this study, it seems reasonable to consider all obese children and adults as being at risk for hyperinsulinism and insulin resistance.9642626
NEUROD1 wt AlleleDeregulated Nutrient SensingHowever, NIDDM patients with the Tyr allele, which was previously reported to be associated with insulin resistance, tended to have lower BMIs than those without this allele (Asp/Asp: 24.5 +/- 1.1 kg/m2, Asp/Tyr: 22.6 +/- 0.4 kg/m2, Tyr/Tyr: 22.8 + 0.3 kg/m2, P = 0.06 by analysis of variance).9653600
NEUROD1 wt AlleleDeregulated Nutrient SensingStiffness indexes beta of the common carotid and femoral arteries are associated with insulin resistance in NIDDM.9653616
FBN2 wt Allele, NEUROD1 wt AlleleDeregulated Nutrient SensingTo investigate the association between arterial wall stiffness indexes beta of the common carotid artery (CCA) and the femoral artery (FA) and insulin resistance in NIDDM subjects in a cross-sectional study.9653616
Arterial Stiffness, FBN2 wt Allele, NEUROD1 wt AlleleDeregulated Nutrient SensingArterial stiffness indexes beta of CCA and FA were associated with insulin resistance in NIDDM subjects.9653616
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingAmong these 36, 21 had coronary disease; the other 15 had, at least, another risk factor, besides dyslipidemia.9656510
Non-compliance, DyslipidemiasDeregulated Nutrient Sensing[Factors involved in the non-compliance of the pharmacologic treatment of dyslipidemia].9656579
Left Ventricular Hypertrophy, Ventricular hypertrophyDeregulated Nutrient SensingLeft ventricular hypertrophy (LVH) has been associated with insulin resistance, a condition with an impaired insulin-mediated vasodilation in skeletal muscle.9657539
Cardiovascular systemDeregulated Nutrient SensingThis indicates that impaired peripheral blood flow (and thereby increased afterload) may be a possible mechanism explaining the previously found association between insulin resistance and cardiovascular hypertrophy.9657539
Increased insulin levelDeregulated Nutrient SensingOur results suggest that the lowered glucose tolerance which follows gastrectomy results from disturbance of the hormonal relationship between pancreas and intestine (entero-insular axis), which causes increased intestinal glucose absorption, and the insulin resistance which occurs in response to hyperinsulinemia in patients with normal fasting plasma glucose.9659817
Microalbuminuria, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingMicroalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study.9662052
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was defined as levels of HDL-cholesterol in the lowest and/or levels of triglyceride in the highest tertile.9662052
Hyperinsulinism, DyslipidemiasDeregulated Nutrient SensingNo associations were found with impaired glucose tolerance, hyperinsulinaemia, IR or dyslipidaemia.9662052
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, immunoglobulin A, Cardiac DeathDeregulated Nutrient SensingElevated levels of IgA, IgE, and IgG are associated with myocardial infarction and cardiac death in men with dyslipidemia.9665352
Dyslipidemias, Coronary ThrombosisDeregulated Nutrient SensingThe present data suggest that, for dyslipidemia to cause coronary atherothrombosis, an immune response reflected by elevated levels of these immunoglobulin classes is an important determinant.9665352
Increased insulin levelDeregulated Nutrient SensingHematocrit and hemoglobin are independently related to insulin resistance and compensatory hyperinsulinemia in healthy, non-obese men and women.9667230
Increased insulin levelDeregulated Nutrient SensingThus, these results suggest that Hct and Hgb concentrations be added to the cluster of variables related to insulin resistance and compensatory hyperinsulinemia.9667230
Weight Gain, Coronary Artery DiseaseDeregulated Nutrient SensingThe changes in lipid levels and blood pressure that occur with excessive weight gain with intensive therapy are similar to those seen in the insulin resistance syndrome and may increase the risk of coronary artery disease in this subset of subjects with time.9669786
Immature, Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingEpidemiological studies have suggested an association between glucose intolerance and hyperinsulinemia with premature CHD in Indian Asians.9672061
Polycystic Ovary Syndrome, metabolic disturbanceDeregulated Nutrient SensingMetabolic disturbances associated with insulin resistance are present in most women with polycystic ovary syndrome.9674665
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThis association, if consistently present, could provide more evidence for a synergistic role for insulin resistance and altered fibrinolysis in the pathogenesis of CHD.9681596
Diastolic blood pressure, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingDiabetic and IGT subjects were older and had higher levels of BMI, triglyceride, systolic and diastolic blood pressure, and higher prevalence of obesity, hypertension, and dyslipidemia but indulged in less physical activity than non-diabetic subjects.9686696
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingFurthermore, these findings support the hypothesis that cardiovascular disease risk commences with rising glucose concentrations before 'conventionally-defined' glucose intolerance occurs.9686697
Tumor necrosisDeregulated Nutrient SensingAdvancing age and insulin resistance: role of plasma tumor necrosis factor-alpha.9688632
Obesity, Diabetes MellitusDeregulated Nutrient SensingWe report a study of 10 candidate genes presumably involved in diabetes or insulin resistance or obesity among Pondicherian Tamil Indians, an isolated population with a high prevalence of diabetes.9690058
Dyslipidemias, diabeticDeregulated Nutrient SensingOur data demonstrate an increased platelet adhesion and aggregation in diabetic patients and suggest a modulatory role of diabetic dyslipidemia.9692617
Hypertension, CTCAEDeregulated Nutrient SensingHypertension and insulin resistance in a native unindustrialised rural population of India.9699937
Glucose Intolerance (disease), AtherosclerosisDeregulated Nutrient SensingUltrasonographic manifestations of carotid atherosclerosis and glucose intolerance in elderly eastern Finnish men.9702446
Hypertensive (finding), HyperinsulinismDeregulated Nutrient SensingHyperinsulinaemia in hypertensive subjects: validity of a test for the detection of insulin resistance in clinical practice.9702932
Hypertensive (finding), HyperinsulinismDeregulated Nutrient SensingTo determine the prevalence of hyperinsulinaemia in non-diabetic hypertensive subjects and to investigate the validity of a simple test for the detection of insulin resistance/hyperinsulinaemia.9702932
Antihypertensive AgentsDeregulated Nutrient SensingOur results suggest that hyperinsulinaemia/insulin resistance in hypertensives becomes identifiable by using simple measurements of BMI, WHR, serum triglycerides and HDL cholesterol as well as the oral glucose tolerance test as means.9702932
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance in essential hypertension is related to plasma renin activity.9705039
Hypertension, CTCAEDeregulated Nutrient SensingIn conclusion, the present investigation showed that insulin resistance is associated with elevated levels of PRA in patients with untreated essential hypertension.9705039
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingAgents that ameliorate insulin resistance and reduce circulating insulin levels could provide a new therapeutic modality for PCOS.9709933
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingWe conclude that a fasting G:I ratio may be useful as a screening test for insulin resistance in obese non-Hispanic white PCOS women.9709933
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient Sensingobesity, type 2 diabetes mellitus, dyslipidemia, or hypertension) were detected.9709965
No metabolic abnormalities, Diabetes MellitusDeregulated Nutrient SensingThe finding of an association between high plasma levels of TNF-alpha and several metabolic abnormalities characteristic for the insulin resistance syndrome suggests that TNF-alpha may be involved in the pathogenesis of non-insulin-dependent diabetes mellitus.9714125
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingTo investigate the number of people with intolerance to glucose (ITG) and undiagnosed diabetes (DM) among primary care users at risk.9717347
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient Sensing[The selective detection of glucose intolerance and diabetes in primary care.9717347
Muscle damage, pancreatic juiceDeregulated Nutrient SensingEccentric exercise (ECC) causes muscle damage, insulin resistance, and increased pancreatic beta-cell secretion in young individuals.9725813
Hypertension, CTCAEDeregulated Nutrient SensingDeteriorated insulin resistance was described in patients with essential hypertension.9727207
Conn Syndrome, Hypertension, CTCAEDeregulated Nutrient SensingThe objective of the present study was to test at the receptor and postreceptor level the presence of insulin resistance in hypertension with primary hyperaldosteronism.9727207
Conn SyndromeDeregulated Nutrient SensingIt may be stated that primary hyperaldosteronism is associated with insulin resistance at the postreceptor level.9727207
Renal Insufficiency, Communicable Diseases, Glucose Intolerance (disease)Deregulated Nutrient SensingThe overall rates of infection, impaired renal function (31.5% vs 21.4%), and glucose intolerance (7.0% vs 4.3%) did not differ significantly between the tacrolimus and cyclosporine treatment groups.9730426
Dyslipidemias, Shock, CardiogenicDeregulated Nutrient SensingOn multivariate analysis, cardiogenic shock on admission and absence of dyslipidemia were strong and independent predictors (p = 0.01) of IRA reocclusion.9732878
Osteoporosis, Vascular calcification, Ulcer, Cataract, Glucose Intolerance (disease), Werner Syndrome, HypogonadismDeregulated Nutrient SensingWerner's syndrome associates early aging in young adults, small height, cataract, glucose intolerance, hypogonadism, skin ulcers, vascular calcifications and osteoporosis.9747202
Diabetes Mellitus, Insulin-Dependent, Dyslipidemias, Hyperglycemia, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMoreover, the presence and importance of abnormalities such as high low-density lipoprotein (LDL) cholesterol and triglycerides levels as CHD risk factors in insulin-dependent diabetes mellitus type 1 have been downplayed, while increasing evidence suggests that the management of type 1 patients should include control of dyslipidemia and hyperglycemia and an effective antihypertensive treatment able also to reduce risk factors for coronary artery events.9747962
ObesityDeregulated Nutrient SensingSimilarly, biochemical parameters considered as general markers of insulin resistance (often associated with obesity) did not correlate significantly with leptinemia.9750462
Increased insulin levelDeregulated Nutrient SensingThe symptoms develop on the background of insulin resistance and are associated with hyperinsulinism.9750464
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingIt has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension.9752890
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingOn the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established.9752890
ObesityDeregulated Nutrient SensingThese data indicate that obesity decreases glucose tolerance by way of progressively increased insulin resistance and, in the case of prolonged duration, by decreased insulin secretion as well.9753008
Metabolic DiseasesDeregulated Nutrient SensingPrevalence of insulin resistance in metabolic disorders: the Bruneck Study.9753305
Metabolic DiseasesDeregulated Nutrient SensingThe prevalence of insulin resistance in the most common metabolic disorders is still an undefined issue.9753305
Hypercholesterolemia, Hypertension, CTCAE, HyperuricemiaDeregulated Nutrient SensingIn isolated hypercholesterolemia, hypertension, or hyperuricemia, prevalence rates of insulin resistance were not higher than that in nonobese normal subjects.9753305
Hyperuricemia, Dyslipidemias, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingAn appreciable number of subjects (n = 85, 9.6% of the whole population) was insulin resistant but free of IGT, NIDDM, dyslipidemia, hyperuricemia, and hypertension.9753305
Hyperglycemia, Saint LuciaDeregulated Nutrient SensingBCAAs solution causes hyperglycemia in mild LC due to insulin resistance, whereas it causes only a slight increase in severe LC due to hepatic glucagon resistance.9754734
Glucose Intolerance (disease)Deregulated Nutrient SensingThere was a gradual decrease in mean height (cm) as glucose intolerance became more severe: N: 161.0 +/- 6.2, OAV:160.2 +/- 6.1, GDM:158.7 +/- 6.3, Type II diabetes 158.2 +/- 7.0 (p < 0.001, analysis of variance].9754816
DyslipidemiasDeregulated Nutrient SensingThe presence of small LDL particles appears to be an early and unexplained feature of the uraemic dyslipidaemia.9761510
Dysfunctional ventilatory weaning responseDeregulated Nutrient SensingInsulin resistance may contribute to the previously unexplained association between ventilatory function impairment and cardiovascular mortality.9762792
Dysfunctional ventilatory weaning response, Coronary heart diseaseDeregulated Nutrient SensingThese findings are consistent with the possibility that insulin resistance may be one of the factors mediating the previously unexplained prospective association between impairment of ventilatory function and risk of mortality from coronary heart disease.9762793
Glucose Intolerance (disease)Deregulated Nutrient SensingAdditional adjustment for baseline postcarbohydrate challenge glucose levels made little difference to the results, suggesting that baseline glucose intolerance was not a significant source of bias.9762793
Hyperlipidemia, USF1 wt AlleleDeregulated Nutrient SensingFamilial combined hyperlipidemia (FCHL) is characterized by hyperlipidemia and insulin resistance, but intracellular defect in insulin action is unknown.9763525
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingImpaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?9763525
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingIn FCHL family members without dyslipidemia and in control subjects, FFAs during the clamp correlated positively with levels of total triglycerides (P<0.001) and very low density lipoprotein cholesterol (P=0.008).9763525
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingWe conclude that in patients with FCHL, and also in their first-degree relatives, insulin's suppressive effect on FFA levels is impaired, which may precede dyslipidemia in FCHL.9763525
AdrenarcheDeregulated Nutrient SensingRecently, pronounced adrenarche and insulin resistance have each been related to low birth weight.9768664
Hypertension, CTCAEDeregulated Nutrient SensingThe relationship between insulin resistance and abnormality of cellular calcium metabolism in patients with essential hypertension.9772426
Weight GainDeregulated Nutrient SensingWeight gain and the risk of developing insulin resistance syndrome.9773723
Weight GainDeregulated Nutrient SensingMoreover, there was a strong graded association between categories of weight gain and risk of insulin resistance syndrome.9773723
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingIn this study both sets of criteria diagnosed a similar number of diabetic subjects, but many of the subjects shifted between glucose intolerance categories.9773731
Beta-cell dysfunctionDeregulated Nutrient SensingThe abnormalities of glucose metabolism in nondippers could be explained by insulin resistance and beta-cell dysfunction.9773741
Hypertensive (finding), Hypertension, CTCAE, Glucose Intolerance (disease)Deregulated Nutrient SensingThe goals of this study were to compare glucose tolerance in dipper and nondipper hypertensive patients and to explore the cause of glucose intolerance in essential hypertension.9773741
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThe dyslipidemia of chronic renal failure may worsen after the commencement of continuous ambulatory peritoneal dialysis (CAPD).9773795
Hyperglycemia, Weight decreased, Diabetes MellitusDeregulated Nutrient SensingWeight loss can therefore, at least in the short term, act to decrease the risk of developing diabetes by reducing insulin resistance, and thus relieving beta-cell stress, the factor ultimately responsible for hyperglycaemia in predisposed individuals.9777320
AtherosclerosisDeregulated Nutrient SensingRelationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study.9781617
AtherosclerosisDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study (IRAS) is a multicenter epidemiologic study conducted at four clinical centers in California, Texas, and Colorado.9781617
OverweightDeregulated Nutrient SensingACE inhibition but not angiotensin II antagonism reduces plasma fibrinogen and insulin resistance in overweight hypertensive patients.9781930
Hypertensive diseaseDeregulated Nutrient SensingThese findings suggest that insulin resistance may play a role in the pathogenesis of the hypertensive disorders of pregnancy.9790393
NEUROD1 wt AlleleDeregulated Nutrient SensingWe studied an extended pedigree in which multiple members are affected by late-onset NIDDM associated with insulin resistance and performed linkage analysis with four microsatellite markers in the MODY3 region of chromosome 12q.9792550
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThese results confirm that the association between reduced fetal growth and glucose intolerance is mediated through insulin resistance and depends upon an interaction with obesity in adult life.9794098
Glucose Intolerance (disease), Failure (biologic function)Deregulated Nutrient SensingFailure to stratify by gestational age in previous studies could account for inconsistencies in the relations of insulin resistance and glucose intolerance to size at birth and for the detection of stronger associations with ponderal index than with birthweight.9794098
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAfter adjusting for adult body mass index, prevalence of glucose intolerance (defined as diabetes or impaired glucose tolerance) was inversely related to birthweight.9794098
Adenoma, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan).9794177
Metabolic Diseases, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingThe association of clusters of risk factors and their relations with coronary heart disease provide important clues that may be used in understanding the metabolic disorders associated with insulin resistance and diabetes.9801017
Blood Glucose, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOther vascular risk factors able to influence fibrinolytic parameters such as glycemia, obesity, hypertension, dyslipidemia, and oxidative stress were also considered.9801931
AtherosclerosisDeregulated Nutrient SensingA cross-sectional analysis was conducted among 623 postmenopausal women in the Insulin Resistance Atherosclerosis Study (IRAS).9802722
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingImpaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study.9802726
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe frequencies of dyslipidemia and nonlipid risk factors in patients with and without CHD were determined and compared.9810294
Glucose Intolerance (disease), Peripheral Arterial DiseasesDeregulated Nutrient SensingGlucose intolerance, physical signs of peripheral artery disease, and risk of cardiovascular events: the Framingham Study.9812089
Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance was associated with a 2-fold excess occurrence of physical signs of PAD (P< .01 ).9812089
Glucose Intolerance (disease), Choline Dehydrogenase, Mitochondrial, Cerebrovascular accident, Congestive heart failureDeregulated Nutrient SensingFemoral and carotid bruits were generally associated with greater increased risk of CHD, CHF, and CVA than was glucose intolerance alone.9812089
Glucose Intolerance (disease), BruitDeregulated Nutrient SensingParticularly in women, the concomitant presence of bruits augmented the CVD risk of glucose intolerance.9812089
Glucose Intolerance (disease)Deregulated Nutrient SensingPhysical findings of PAD appear to signify a compromised arterial circulation to the heart and brain as well as the limbs in persons with glucose intolerance.9812089
Hypertension, CTCAEDeregulated Nutrient SensingTo elucidate the role of hypertension as part of a state of insulin resistance.9816552
Microalbuminuria, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, HypertrophyDeregulated Nutrient Sensinginsulin resistance, on renal function with microalbuminuria, changes of some echocardiographic signs of hypertrophy and compliance of the left ventricle in patients with hypertension and type II diabetes mellitus.9820056
Microalbuminuria, NatriuresisDeregulated Nutrient SensingIn addition to the anticipated drop of blood pressure a declining trend of insulin resistance was recorded, there was a significant decline of microalbuminuria and a rise of natriuresis, the left ventricle mass declined and its compliance improved.9820056
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAgeing is one of the major risk factors for glucose intolerance including impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus.9833938
Coronary Artery DiseaseDeregulated Nutrient SensingSmaller LDL particles are associated with an increased risk for coronary artery disease and have been found predominantly in subjects with the insulin resistance syndrome.9839097
metabolic disturbanceDeregulated Nutrient SensingAlthough insulin resistance has been suggested to be a basic defect, little is known about the relation between this predisposing factor (and associated metabolic disturbances) and LDL size distribution in young and metabolically healthy subjects.9839097
Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingDyslipidaemia (any one of low-HDL-cholesterol, high triglyceride or high cholesterol) was common in both normotensives and hypertensives (40.5% vs 46.4%).9844943
Hyperglycemia, Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingHypertensives showed significantly higher levels of total cholesterol, triglyceride, blood glucose, urate and more clustering of hyperglycaemia and dyslipidaemia than normotensives even after adjustment for BMI.9844943
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingAbdominal visceral fat (AVF) is an obesity-related phenotype thought to be associated with insulin resistance, diabetes mellitus, and atherosclerosis.9851757
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingCurrent zinc intake and risk of diabetes and coronary artery disease and factors associated with insulin resistance in rural and urban populations of North India.9853535
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingTo determine the association between current zinc intake and prevalence of coronary artery disease (CAD) and diabetes as well as factors associated with insulin resistance.9853535
Hypertriglyceridemia, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingLower consumption of dietary zinc and low serum zinc levels were associated with an increased prevalence of CAD and diabetes and several of their associated risk factors including hypertension, hypertriglyceridemia and other factors suggestive of mild insulin resistance in urban subjects.9853535
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of CAD, diabetes and glucose intolerance was significantly higher among subjects consuming lower intakes of dietary zinc.9853535
Non-insulin Hypoglycemic, Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing[Relationship between medical treatment compliance and the degree of control in patients with high blood pressure, non-insulin dependent diabetes mellitus and dyslipidemia].9859088
Diabetes Mellitus, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingAssociation of central obesity and insulin resistance with high prevalence of diabetes and cardiovascular disease in an elderly population with low fat intake and lower than normal prevalence of obesity: the Indian paradox.9861517
Cardiovascular Diseases, Diabetes Mellitus, Insulin resistance syndromeDeregulated Nutrient SensingTo test the hypothesis that high prevalences of cardiovascular disease and diabetes in urban population of India are manifestations of insulin-resistance syndrome.9861517
Dyslipidemias, Obesity, Abdominal, Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingImpaired lipolysis has been proposed as a pathogenic factor contributing to clustering of abdominal obesity and dyslipidaemia in Type II (non-insulin-dependent) diabetes mellitus--that is, the metabolic syndrome (MSDR).9867220
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe association between insulin resistance and coronary heart disease (CHD) is strong in the British Indian-Asian population.9868972
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAdipocyte metabolism may contribute to both insulin resistance and CHD.9868972
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingIt is concluded that glucose intolerance and central obesity are common in this region of Uzbekistan, about which there was previously little information.9868981
Hypertension, CTCAEDeregulated Nutrient SensingTo determine whether kinetic abnormalities in the onset of insulin action contribute to the insulin resistance in obesity-associated hypertension.9869012
DyslipidemiasDeregulated Nutrient SensingFibrinolytic potential is significantly increased by oestrogen treatment in postmenopausal women with mild dyslipidaemia.9875081
DyslipidemiasDeregulated Nutrient SensingHormone replacement treatment with 17 beta-oestradiol for nine weeks significantly increased fibrinolytic potential in postmenopausal women with mild dyslipidaemia.9875081
Primary malignant neoplasmDeregulated Nutrient SensingCirculating interleukin 6 concentrations and insulin resistance in patients with cancer.9876070
Primary malignant neoplasmDeregulated Nutrient SensingThe mechanism of insulin resistance in patients with cancer is not clear.9876070
Primary malignant neoplasmDeregulated Nutrient SensingThese results may suggest that IL-6 is related to insulin resistance in patients with cancer.9876070
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe studied factors manifesting an increase in risk for the development of GSD were age (P<0.05), high body mass index (P< 0.05), diabetes mellitus (adjusted odds ratio: 1.998; P< 0.05) and glucose intolerance (adjusted odds ratio: 2.056; P<0.05) by multivariate analysis.9883999
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAge, high body mass index, diabetes mellitus and glucose intolerance are the risk factors for developing GSD in Taiwan.9883999
Diastolic blood pressureDeregulated Nutrient SensingIn addition, simple linear regressions revealed that both systolic and diastolic blood pressure correlated significantly with serum leptin and the insulin resistance index in both groups.9886890
MicroalbuminuriaDeregulated Nutrient SensingThe O'Sullivan test, on its own or with the microalbuminuria test, seems very useful for identifying obese subjects with resistance to insulin.9887576
Electrocardiogram: myocardial infarction (finding), Coronary Artery Disease, AtherosclerosisDeregulated Nutrient SensingPolymorphisms of angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) genes have been reported to be associated with myocardial infarction and coronary artery disease, both of which are closely related to atherosclerosis and insulin resistance.9893168
Cell secretion, Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Glucose Intolerance (disease)Deregulated Nutrient SensingWomen with polycystic ovary syndrome (PCOS) are insulin resistant, have insulin secretory defects, and are at high risk for glucose intolerance.9920077
Glucose Intolerance (disease), Prostate Cancer Outcomes StudyDeregulated Nutrient SensingWe performed this study to determine the prevalence of glucose intolerance and parameters associated with risk for this in PCOS women.9920077
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of glucose intolerance was 31.1% impaired glucose intolerance (IGT) and 7.5% diabetes.9920077
Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingWe conclude that 1) PCOS women are at significantly increased risk for IGT and type 2 diabetes mellitus at all weights and at a young age; 2) these prevalence rates are similar in 2 different populations of PCOS women, suggesting that PCOS may be a more important risk factor than ethnicity or race for glucose intolerance in young women; and 3) the American Diabetes Association diabetes diagnostic criteria failed to detect a significant number of PCOS women with diabetes by postchallenge glucose values.9920077
Tumor necrosis, Diabetes MellitusDeregulated Nutrient SensingRecent research suggests that tumor necrosis factor-alpha (TNF alpha) may play an important role in obesity-associated insulin resistance and diabetes.9920095
Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingWe studied the relationship between TNF alpha and the anthropometric and physiological variables associated with insulin resistance and diabetes in an isolated Native Canadian population with very high rates of type 2 diabetes mellitus (DM).9920095
Diabetes MellitusDeregulated Nutrient SensingIf confirmed, these data suggest new opportunities for research that include exploring a possible role for carotenoids in the pathogenesis of insulin resistance and diabetes.9921962
Tumor necrosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe role of tumor necrosis factor-alpha in insulin resistance has been studied in 59 patients with Type 2 diabetes, 28 with android type obesity and 35 healthy lean controls.9925347
Obesity, Diabetes MellitusDeregulated Nutrient SensingAccording to these data the cytokine might play a role in insulin resistance in obesity as well in Type 2 diabetes.9925347
Glucose Intolerance (disease)Deregulated Nutrient SensingThe total amount of time spent on physical activity decreased with increasing glucose intolerance.9927216
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThe etiology of non-insulin-dependent diabetes mellitus (NIDDM) is usually explained as a combination of peripheral insulin resistance and impaired beta-cell function.9930938
CDISC SDTM Immunogenicity Specimen Assessments Test Name TerminologyDeregulated Nutrient SensingThe IST showed marked insulin resistance in both parents and the older son, and moderate resistance in the younger son, previously not described.9930938
NEUROD1 wt AlleleDeregulated Nutrient SensingPFK1-M-deficiency leads to a metabolic state typical for early NIDDM in homozygously affected humans, especially concerning insulin resistance and loss of first phase beta-cell insulin secretion, and may contribute to the manifestation of NIDDM in a subgroup of patients.9930938
Liver CirrhosisDeregulated Nutrient SensingMost patients with cirrhosis of the liver have detectable insulin resistance.9930950
Obesity, Diabetes MellitusDeregulated Nutrient SensingBased on the fact that his urinary C-peptide levels increased, the diabetes mellitus may have been due to insulin resistance with obesity.9932637
Cardiovascular DiseasesDeregulated Nutrient SensingLeptin, important for body weight regulation, may be involved in the pathogenesis of the insulin resistance syndrome, associated with cardiovascular disease.9933268
Increased insulin level, HyperparathyroidismDeregulated Nutrient SensingDisturbances of glucose metabolism with hyperinsulinism and peripheral insulin resistance are frequently observed in patients with hyperparathyroidism.10025037
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingThese data show that serum C3 correlates with a cluster of conventional risk factors for myocardial infarction resembling insulin resistance.10063429
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance was identified from the blood glucose level, HbA1c level and history of diabetes mellitus.10064971
Glucose Intolerance (disease)Deregulated Nutrient SensingThe results suggest that the prevalence of glucose intolerance depends on the environment in which people live.10064971
Cardiovascular Diseases, AtherosclerosisDeregulated Nutrient SensingMS alone and clusters of AP, AO, and HLP characterized by insulin resistance, accelerate the development of cardiovascular diseases associated with atherosclerosis.10067244
TG gene, Increased insulin level, DyslipidemiasDeregulated Nutrient SensingDyslipidemia in the presence of MS and in combinations of AP with AO and HLP was characterized by increased levels of TG and total CS and decreased content of CS and high-density lipoproteins, which was associated with basal hyperinsulinemia.10067244
Hypertension, CTCAE, Coronary Arteriosclerosis, Diabetes MellitusDeregulated Nutrient SensingNon-insulin-dependent diabetes, hypertension and ischaemic heart disease, with insulin resistance, are associated with low birth weight (the 'Small Baby Syndrome').10070502
Increased insulin level, Glucose Intolerance (disease), Depressed mood, AtherosclerosisDeregulated Nutrient SensingDecreased fibrinolysis in the presence of subclinical disease in subjects with hyperinsulinemia or glucose intolerance is consistent with the premise that depressed plasmin generation may enhance the progression of atherosclerosis in these people.10073949
Microalbuminuria, Hypertension, CTCAEDeregulated Nutrient SensingTherefore, it is suspected that microalbuminuria is a renal facet of insulin resistance, and a predictor value of hypertension.10075379
Apolipoprotein E, Cholelithiasis, Glucose Intolerance (disease)Deregulated Nutrient SensingThe role of apolipoprotein E and glucose intolerance in gallstone disease in middle aged subjects.10075965
Hyperleucinemia, Increased insulin level, DyslipidemiasDeregulated Nutrient SensingTo determine if fat deposition within mid-thigh muscle, represented by low density lean tissue density, is associated with age, low physical fitness, hyperleptinemia, hyperinsulinemia and dyslipidemia in women.10078845
CD55 gene, HypertriglyceridemiaDeregulated Nutrient SensingInsulin resistance is associated with hypertriglyceridemia, low serum high-density lipoprotein cholesterol (HDL-C) concentrations and high serum total cholesterol (TC) to HDL-C ratios.10083765
ObesityDeregulated Nutrient SensingThis reduction in 11betaHSD1 activity raises new questions as to the primary role of 11betaHSD1 in the pathogenesis of insulin resistance and central obesity.10084590
ThalassemiaDeregulated Nutrient SensingMoreover non-diabetic thalassaemic patients showed a clear reduction of both beta-cell function and insulin resistance indices (HOMA model).10091158
Glucose Intolerance (disease), Primary Hypothyroidism, ThalassemiaDeregulated Nutrient SensingGlucose intolerance and primary hypothyroidism were less frequent (24 and 5.7%, respectively) and milder than in thalassaemia major patients.10091174
Insulin resistance syndromeDeregulated Nutrient SensingGlucose tolerance and insulin-resistance syndrome among St. Lawrence Island Eskimos.10093304
NEUROD1 wt Allele, Insulin resistance syndromeDeregulated Nutrient SensingAlthough NIDDM prevalence was not high compared to non-Native U.S. residents, elements of the insulin-resistance syndrome exist in this subarctic population.10093304
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe transition in glucose intolerance from Cameroon to Jamaica and Britain suggests that environment determines diabetes prevalence in these populations of similar genetic origin.10097925
Inflammatory Bowel DiseasesDeregulated Nutrient SensingMoreover, glucocorticoids, which are widely used in the treatment of inflammatory bowel disease, are notoriously related to insulin resistance.10102952
Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSubjects with diabetes, hypertension, and heart disease reported lower predicted VO2max than their healthier counterparts (p < .0001), but this was not the case for dyslipidemia subjects (27.6 +/- 7.6 vs. 27.4 +/- 8.2 ml/kg/min, respectively; p > .58).10181139
Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA larger proportion of diseased subjects was in the lowest fitness quintile for diabetes, hypertension, and heart disease, but not for dyslipidemia.10181139
Hypertensive (finding)Deregulated Nutrient SensingThe prevalence of hyperinsulinemia/insulin resistance in hypertensive individuals, as well as the effects of insulin on myocytic and fibroblastic growth, are well known in both epidemiologic and animal models.10192231
Hypertensive (finding), Central visual impairmentDeregulated Nutrient SensingHyperinsulinemia/insulin resistance could cause an altered collagen/muscular ratio, which could potentially explain, at least in part, the CVI alterations detected in hypertensive patients.10192231
Angina PectorisDeregulated Nutrient SensingAngiotensin I converting enzyme gene polymorphism and insulin resistance in patients with angina pectoris.10192232
Angina PectorisDeregulated Nutrient SensingIn conclusion, the D allele was not associated with higher insulin resistance in patients with angina pectoris; that is, patients with the ID and DD genotypes were associated with a significantly lower risk of insulin resistance, compared to those with the II genotype.10192232
Endothelial dysfunction, ObesityDeregulated Nutrient SensingC-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue?10195925
Endothelial dysfunctionDeregulated Nutrient SensingWe have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction.10195925
Endothelial dysfunction, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingMoreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease.10195925
Weight Gain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRecently, a mutation in the beta 3AR gene (Trp64Arg) has been reported to be associated with features of insulin resistance, weight gain and early onset of Type 2 Diabetes Mellitus.10197086
Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance syndrome has recently been described as a unifying hypothesis to explain the relationship between the many risk factors of coronary heart disease.10198911
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBoth defective insulin secretion and insulin resistance have been reported in relatives of type 2 diabetic subjects.10199785
Hyperlipidemia, Premature coronary artery atherosclerosis, Dyslipidemias, USF1 wt Allele, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingFamilial combined hyperlipidemia (FCHL) is a common dyslipidemia predisposing to premature coronary heart disease (CHD).10205279
NEUROD1 wt AlleleDeregulated Nutrient SensingSince the therapeutic dose of nicorandil did not affect pancreatic B-cell function but caused insulin resistance in both healthy and NIDDM subjects, we conclude that K-ATP channels play a regulatory role in insulin-mediated glucose transport in humans.10206433
DiseaseDeregulated Nutrient SensingInsulin resistance and human disease: a short history.10212844
Dyslipidemias, Vascular System InjuriesDeregulated Nutrient SensingNearly all patients present with dyslipidemia, a prominent vascular risk factor, probably responsible for the high rate of vascular injury.10215333
Hypertriglyceridemia, ObesityDeregulated Nutrient SensingMultivariate analysis indicated that older age and high level of low-density-lipoprotein cholesterol corresponded to an elevated Lp(a) level, while hypertriglyceridemia, low high-density-lipoprotein cholesterol level, obesity and high insulin resistance corresponded to a lower Lp(a) level.10217355
Hypertriglyceridemia, metabolic disturbanceDeregulated Nutrient SensingWhile hypertriglyceridaemia may exert an influence independent of other lipid factors, insulin resistance is probably the underlying metabolic disturbance.10217356
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingClinico-hemodynamic parameters, lipid blood spectrum and plasmic hemostasis were studied in 28 elderly CHD patients divided into groups by dyslipidemia type (IIA, IIB, IV).10222562
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe proposed balanced antiatherogenic vegetarian diet proved to be an effective monotherapy of dyslipidemia in elderly patients with coronary heart disease.10222562
Glucose Intolerance (disease), Pancreatic carcinomaDeregulated Nutrient SensingThe mechanisms responsible for glucose intolerance in patients with pancreatic cancer remain controversial.10228759
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingThe authors compared the abilities of descriptive and valuational health-related quality-of-life measures to discriminate healthy participants (n=39) from those on diets for dyslipidemia (n=35) and angina patients (n=30).10231077
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingOn the rating scale, the time tradeoff, and the General Health Perception subscale of the SF-36 Health Survey, the participants with dyslipidemia or angina reported lower mean scores than the healthy participants.10231077
Congestive heart failureDeregulated Nutrient SensingPrevious studies have demonstrated that insulin resistance is a common feature of congestive heart failure (CHF), but the clinical significance of such insulin resistance is still debated.10235092
AcromegalyDeregulated Nutrient SensingInsulin-mediated pseudoacromegaly in a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired phosphatidylinositol 3-kinase activity in fibroblasts.10320056
Acanthosis Nigricans, Obesity, HypothyroidismDeregulated Nutrient SensingAcanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: improvement by diet control.10325466
Acanthosis Nigricans, Obesity, HypothyroidismDeregulated Nutrient SensingWe report on a 27-year-old man with acanthosis nigricans (AN) associated with severe obesity, insulin resistance and hypothyroidism.10325466
HypothyroidismDeregulated Nutrient SensingThis confirms that AN may be mainly attributed to insulin resistance rather than hypothyroidism per se.10325466
Weight GainDeregulated Nutrient SensingWeight gain and insulin resistance during nicotine replacement therapy.10326169
Weight Gain, Myocardial Ischemia, Coronary heart diseaseDeregulated Nutrient SensingAlthough the cessation of smoking reduces the increased risk for ischemic heart disease, it is associated with marked weight gain and presumably insulin resistance, both of which heighten the risk of coronary heart disease.10326169
Weight GainDeregulated Nutrient SensingSmoking cessation is associated with weight gain and improvement in insulin resistance.10326169
Weight GainDeregulated Nutrient SensingNicotine is the main ingredient in cigarette smoke causing insulin resistance, but the withdrawal of another, unknown ingredient in cigarette smoke is responsible for the weight gain associated with smoking cessation.10326169
Autoimmune Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is not an autoimmune disease but rather results from both insulin resistance and a nonautoimmune insulin secretory defect.10331401
TG gene, ObesityDeregulated Nutrient SensingIf fasting TG was <1.7 mmol/l (isolated low HDL cholesterol), individuals were similar to the general population in terms of insulin resistance and obesity.10331414
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingThe higher prevalence of isolated low HDL cholesterol, the young age at which individuals exhibit this phenotype (mean age 32.5 years), along with the greater propensity for Asian Indians to develop insulin resistance and IGT contribute to the threefold increased incidence of myocardial infarction in those <65 years of age in this ethnic group.10331414
diabeticDeregulated Nutrient SensingHomeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas.10332688
diabeticDeregulated Nutrient SensingThe 80 subjects, selected because they had not received insulin therapy, were among 111 diabetic participants in a clamp study for evaluation of insulin resistance from May 1993 to December 1997 in Osaka City University Hospital.10332688
Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Kidney DiseasesDeregulated Nutrient SensingFurthermore, there was an excess of risk factors for development of Type II diabetes (higher fasting plasma glucose concentrations, higher prevalence of hypertension, higher waist-hip ratio and a tendency towards more glucose intolerance) among previously non-diabetic parents of patients with nephropathy.10333042
Autoimmune Diseases, Obesity, Beta-Cell Function MeasurementDeregulated Nutrient SensingThis observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance.10333047
Hypertension, CTCAEDeregulated Nutrient SensingRole of insulin resistance in the genesis of sodium sensitivity in essential hypertension.10333344
Hypertension, CTCAEDeregulated Nutrient SensingThese results showed that insulin resistance might participate in the genesis of sodium sensitivity in essential hypertension by enhancing tubular sodium reabsorption, as reflected in decreased FE(Na) and augmented creatinine clearance.10333344
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance seemed elevated in sodium sensitive state of essential hypertension, leading to future cardiovascular events.10333344
Dyslipidemias, Hypertension, CTCAE, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingThe increased cardiovascular risk in subjects with NIDDM is partly explained by an association with established risk factors like hypertension, dyslipidemia, and obesity.10333913
Hyperhomocysteinemia, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHyperhomocysteinemia did not cluster with other cardiovascular risk factors, like hypertension, obesity, or dyslipidemia.10333913
Maturity Onset Diabetes of the Young Pathway, Diabetes mellitus autosomal dominant type II (disorder), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur findings indicate the existence of forms of early-onset autosomal-dominant type 2 diabetes that are distinct from MODY and are frequently characterized by insulin resistance, similar to later-onset type 2 diabetes.10333942
Hyperglycemia, Dyslipidemias, Pathologic Intimal Thickening, Diabetes MellitusDeregulated Nutrient SensingOur data suggest that hyperglycemia, together with a clustering of risk factors, and in particular dyslipidemia, may cause intimal-medial thickening in the early phases of diabetes.10333954
ObesityDeregulated Nutrient SensingVariation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects.10337870
ObesityDeregulated Nutrient SensingAn alanine to threonine substitution at codon 54 of the fatty acid binding protein 2 (FABP2) gene has been associated with insulin resistance in Pima Indians and with obesity in aboriginal Canadians.10337870
ObesityDeregulated Nutrient SensingThese results suggest that the polymorphism at codon 54 of the FABP2 gene is not a major contributing factor to obesity and insulin resistance in Japanese subjects.10337870
Tumor necrosis, ObesityDeregulated Nutrient SensingRecently an important role of the cytokine tumor necrosis factor-alpha in mediating insulin resistance of obesity through its overexpression in fat tissue has been reported.10340439
ObesityDeregulated Nutrient SensingIn order to examine the relation of insulin resistance to obesity and to serum neopterin, as a parameter of immune activation, we studied 1234 otherwise healthy outpatients, who visited the physician's office for a medical health check-up.10340439
Tumor necrosisDeregulated Nutrient SensingThe data may indicate that moderate immune stimulation plays a role in the development of insulin resistance, and an influence of tumor necrosis factor-alpha seems to be probable.10340439
Diabetes MellitusDeregulated Nutrient SensingHypothalamic arousal, insulin resistance and Type 2 diabetes mellitus.10342336
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (DM) develops when insulin resistance overcomes the capacity of compensatory insulin secretion.10342336
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingA polymorphism of the glucocorticoid receptor gene, with 13.7% homozygotes in the male Swedish population, parallels receptor dysfunction, and may be responsible for the associated insulin resistance, central obesity and hypertension.10342336
No endocrine abnormalities, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe results suggest that an hypothalamic arousal syndrome, with parallel activation of the HPA axis and the central sympathetic nervous system, is responsible for development of endocrine abnormalities, insulin resistance, central obesity, dyslipidaemia and hypertension, leading to frank disease, including Type 2 DM.10342336
Hyperinsulinism, Polycystic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance with compensatory hyperinsulinaemia has been reported in adult polycystic kidney disease (APKD) patients.10344369
Communicable Diseases, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingA significant correlation was found between chronic C pneumoniae infection and dyslipidemias in the AMI and CHD groups (P =.003; P =.10347340
Increased insulin level, Hypertension, CTCAE, MPV17 geneDeregulated Nutrient SensingInsulin resistance and hyperinsulinemia induce glomerular hypertension and hyperfiltration, which may result in glomerulosclerosis.10354294
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingObesity was more prevalent among those with glucose intolerance (IGT + DM) than those with NGT, and those who were obese had the highest prevalence of glucose intolerance.10355474
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingA greater percentage of those with glucose intolerance had more than one positive obesity measure as compared to those with NGT, and those with more than one index consistent with obesity had a greater prevalence of IGT + DM.10355474
Glucose Intolerance (disease), Demographics Domain, ObesityDeregulated Nutrient SensingPrevalence rates of DM and obesity are high among the Louisiana Coushatta, and obesity is associated with glucose intolerance.10355474
Diabetes MellitusDeregulated Nutrient SensingBirth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults.10372247
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe insulin resistance of low-birth-weight Pima Indians may explain their increased risk for type 2 diabetes.10372247
Cardiovascular DiseasesDeregulated Nutrient SensingMany studies have shown that this phenomenoa is associated with a increased morbility of cardiovascular disease, and insulin resistance may be the common link between the risk factors.10374288
Cardiovascular DiseasesDeregulated Nutrient SensingThe insulin resistance is associated with a clustering of risk factors of cardiovascular disease, more cluste-ring, more resistant.10374288
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingAlthough numerous studies have demonstrated obesity as an aspect of the insulin resistance syndrome in cardiovascular disease (CVD), the mechanism is not clear.10375053
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingInsulin resistance, often associated with obesity, is hypothesized to be involved in the pathogenesis of essential hypertension and may relate to increased left ventricular mass (LVM).10385774
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingLow birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men.10388964
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingTo investigate the association between low birth weight and glucose intolerance in relation to family history of diabetes.10388964
Ischemic strokeDeregulated Nutrient SensingAspects of insulin resistance, as reflected by elevated waist-to-hip ratios and elevated fasting insulin levels, may also contribute to a greater risk of ischemic stroke.10388971
Increased insulin levelDeregulated Nutrient SensingWhether serum leptin levels are associated with insulin resistance independent of the effects of hyperinsulinemia and adiposity is an important unanswered question.10388973
Ischemic stroke, diabeticDeregulated Nutrient SensingInsulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke.10388988
Hypertension, CTCAE, AtherosclerosisDeregulated Nutrient SensingIn addition to classic risk factors (e.g., hypertension), insulin resistance is an important risk factor for the development of atherosclerosis.10388988
Diabetes Mellitus, Non-Insulin-Dependent, Ischemic strokeDeregulated Nutrient SensingMultiple logistical regression analysis showed that insulin resistance was an independent risk factor for all subtypes of ischemic stroke in type 2 diabetic patients.10388988
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSince there is a Pro12Ala substitution in this domain, we tested whether it is related to type 2 diabetes or insulin resistance.10389855
Glucose Intolerance (disease), CholelithiasisDeregulated Nutrient SensingThe findings add to evidence that glucose intolerance is associated with a modest increase in the risk of gallstone disease.10395054
DyslipidemiasDeregulated Nutrient SensingAn increase in serum lipoprotein(a) was also observed in the subjects with the heterozygous mutation, but the Trp64Arg mutation was not associated with other dyslipidemia, blood pressure or ischemic changes on the electrocardiogram.10395234
Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.10402440
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously.10402440
Choline Dehydrogenase, Mitochondrial, Cerebrovascular accidentDeregulated Nutrient SensingIn women, the insulin resistance factor did not predict CHD events (HR 1.06, CI 0.82, 1.36), but factor 2 (previous stroke, low HDL cholesterol and high triglycerides) (HR 1.34, CI 1.10402440
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingOur study supports the notion that the insulin resistance syndrome is a risk factor for CHD in elderly men.10402440
Dyslipidemias, Prediabetes syndromeDeregulated Nutrient SensingDyslipidemia in patients with diabetic uremic patients remains unclear.10412780
DyslipidemiasDeregulated Nutrient SensingMixed dyslipidemia with moderately elevated low-density lipoprotein (LDL) cholesterol and high levels of triglyceride-rich lipoproteins is common in this condition.10412782
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt is not known, however, whether patients with type 2 diabetes on dialysis with this form of dyslipidemia derive benefit from lipid-lowering therapy.10412782
Vascular lesions, DyslipidemiasDeregulated Nutrient SensingThe resolution of this question is important because the genesis of vascular lesions in this condition is multifactorial and the precise role of dyslipidemia has not been defined.10412782
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance, a major factor in the pathogenesis of type 2 diabetes mellitus, is due mostly to decreased stimulation of glycogen synthesis in muscle by insulin.10413736
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThe aim of this study was to investigate the association of insulin secretion and insulin resistance with the development of non-insulin-dependent diabetes mellitus (NIDDM) in obese (body mass index (BMI) > or = 25 kg/m2) and non-obese Japanese.10414932
Diabetes MellitusDeregulated Nutrient SensingWe conclude that most cases of diabetes in Japanese begin with decreased insulin secretion, but a small group of diabetes patients may start with insulin resistance, especially obese subjects.10414932
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria.10414936
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingTherefore, OGTT remains a valuable test in diagnosing diabetes and classifying various categories of glucose intolerance.10414936
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingPakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in Baluchistan province.10414940
Beta-cell dysfunctionDeregulated Nutrient SensingFasting concentrations and secretion response of insulin, proinsulin, and C-peptide to glucose ingestion was significantly increased in the PI-treated group suggesting a beta-cell dysfunction in addition to peripheral insulin resistance.10416516
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingTreatment of dyslipidemia and its frequently associated complications (manifest atherosclerosis) is very pretentious from the economic aspect.10422514
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo identify abnormally expressed genes contributing to muscle insulin resistance in type 2 diabetes, we screened the mRNA populations from normal and diabetic human skeletal muscle using cDNA differential display and isolated abnormally expressed cDNA clones of mitochondrial-encoded NADH dehydrogenase 1 (ND1), cytochrome oxidase 1, tRNA(leu), and displacement loop.10426366
Endocrine System DiseasesDeregulated Nutrient SensingSuccessful treatment for these endocrinopathies resulted in greatly improved blood sugar control because of a reduction in insulin resistance.10426577
Cushing Syndrome, AcromegalyDeregulated Nutrient SensingThis is the first report describing insulin resistance before and after treatment in a case of acromegaly accompanied by adrenal preclinical Cushing's syndrome.10426577
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAmong the aged senior citizens in Taiwan, individuals with old age, lower serum high-density lipoprotein level, diabetes and glucose intolerance are at high risk for developing GSD.10430304
Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingProtein tyrosine phosphatases (PTPs) are required for the dephosphorylation of the insulin receptor (IR) and its initial cellular substrates, and it has recently been reported that PTP-1B may play a role in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus (DM).10444024
square decimeter, ObesityDeregulated Nutrient SensingThese data suggest that the insulin resistance of obesity and DM2 is characterized by the increased expression of a catalytically impaired PTP-1B in adipose tissue and that impaired PTP-1B activity may be pathogenic for insulin resistance in these conditions.10444024
Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingWe suggest large losses of chromium over many years may exacerbate an already compromised chromium status in NIDDM patients and might contribute to the developing insulin resistance seen in patients with type 2 diabetes.10445219
Obesity, AtherosclerosisDeregulated Nutrient SensingAssociations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women.10446082
Obesity, AtherosclerosisDeregulated Nutrient SensingObesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all be determinants of an increased acute-phase response.10446082
diabeticDeregulated Nutrient SensingThe efficacy and safety of treatment with troglitazone combined with an alpha-glucosidase inhibitor, in obese type 2 diabetic patients who were previously administered alpha-glucosidase inhibitors alone, in improving glycaemic control and reducing insulin resistance were studied.10446691
Hypercholesterolemia, Hyperinsulinism, Family history, AtherosclerosisDeregulated Nutrient SensingTo study the relationship between hyperinsulinaemia, insulin resistance, leptin and atherosclerosis in subjects with familial hypercholesterolaemia (FH).10447228
Family historyDeregulated Nutrient SensingFasting insulin concentrations and calculated insulin resistance were similar in FH subjects with overt CAD compared to those without.10447228
Family historyDeregulated Nutrient SensingIn the absence of other causes of insulin resistance, FH subjects have normal fasting insulin levels and, in general, they are not insulin resistant.10447228
Family history, AtherosclerosisDeregulated Nutrient SensingInsulin resistance appears to play little role in the pathogenesis of accelerated atherosclerosis in FH.10447228
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingThe relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study.10447516
HyperglycemiaDeregulated Nutrient SensingThis could be secondary to hyperglycaemia or insulin resistance or due to a defect in insulin secretion.10447516
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (low insulin sensitivity) was not related to the intact proinsulin:insulin ratio in subjects with Type II diabetes.10447516
Primary malignant neoplasmDeregulated Nutrient SensingInsulin resistance was connected with the alterations of substrate utilization in patients with cancer.10454248
Primary malignant neoplasmDeregulated Nutrient SensingTo elucidate the contribution of insulin resistance to substrate utilization, insulin sensitivity and substrate oxidation were examined in 19 cancer patients and five normal controls using the euglycemic hyperinsulinemic glucose clamp technique combined with indirect calorimetry.10454248
Primary malignant neoplasmDeregulated Nutrient SensingIn cancer patients with insulin resistance, decreased glucose uptake was closely associated with a rapid decrease in glucose storage, an increase in fat oxidation and a mild decrease in glucose oxidation, suggesting that insulin resistance was connected with the alterations of substrate utilization which may induce host depletion.10454248
Proteinuria, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingData on fasting glucose, obesity, persistent proteinuria, smoking, hypertension, and dyslipidemia were obtained at diagnosis for confirmed incidence cases.10455512
Glucose Intolerance (disease), Digestive System DisordersDeregulated Nutrient SensingSuch operations may cause digestive disorders, glucose intolerance, and late postsplenectomy infection.10457309
HypoglycemiaDeregulated Nutrient SensingHowever, GH therapy resulted in increased insulin resistance during hypoglycemia, without changes in the counterregulatory hormonal responses, serum IGFBP-1, or serum FFA.10459565
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingSixty-seven (84%) had sole hypercholesterolemia, 13 (16%) subjects had mixed dyslipidemia.10460070
ObesityDeregulated Nutrient SensingWe postulate that this may reflect decreased lipoprotein and/or hepatic lipase activity related to insulin resistance and its association with obesity.10460697
Alzheimers Disease", Apolipoprotein E, Data types - AddressDeregulated Nutrient SensingHigher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (APOE)-epsilon4 allele.10461029
HAIR-AN syndromeDeregulated Nutrient SensingAN often forms HAIR-AN syndrome consisted of hyperandrogenizm, insulin resistance and AN.10462985
Hyperactive behavior, Congenital AbnormalityDeregulated Nutrient SensingOf note, syndrome X patients also manifested Na(+)/Li(+) countertransport hyperactivity which, in turn, is known to induce peripheral insulin resistance and consequent abnormalities in insulin secretion and lipid turnover.10464063
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThese high-risk CHD survivors would benefit from more aggressive measures aimed at correcting their dyslipidaemias.10464785
Left Ventricular Hypertrophy, Hypertensive (finding)Deregulated Nutrient SensingIn this study, we examined the relationships between insulin resistance and LVH and LVDF in hypertensive patients from the therapeutic perspective.10466471
Left Ventricular HypertrophyDeregulated Nutrient SensingThe results of this study indicate that insulin resistance is an important factor affecting LVH and LVDF.10466471
Dyslipidemias, ObesityDeregulated Nutrient SensingThese two groups were entirely comparable for all criteria (sociodemographic criteria, risk factors, cardiovascular history, duration of disease) except for obesity and dyslipidaemia, for which prevalence was higher in the naftidrofuryl group.10467531
Myotonic DystrophyDeregulated Nutrient SensingMyotonic dystrophy (MyD) is a systemic disorder in which insulin resistance is well recognized.10468921
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingReduced glucose effectiveness as a feature of glucose intolerance: evidence in elderly type-2 diabetic subjects.10476312
Coronary Artery DiseaseDeregulated Nutrient SensingAttention has been paid to the relationship between insulin resistance and coronary artery disease.10478807
Coronary Stenosis, Calcinosis, AtherosclerosisDeregulated Nutrient SensingTo evaluate the role of insulin resistance on coronary atherosclerosis, angiographic semiquantitative scores of coronary stenosis and calcification were evaluated.10480298
Hypercholesterolemia, Hypertension, CTCAE, HyperuricemiaDeregulated Nutrient SensingThe incidence of hypertension, smoking habits, hypercholesterolemia, and hyperuricemia were also the same among the insulin resistance subgroups.10480298
diabeticDeregulated Nutrient SensingCompared with control subjects, diabetic patients were more obese, hyperglycemic, and had worse lipid profile, higher blood pressures, UAE, insulin resistance index, plasma insulin, and cortisol concentrations (all P < 0.001) but lower GH concentrations (P < 0.05).10480508
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results suggest that abnormalities in vascular reactivity and biochemical markers of endothelial cell activation are present early in individuals at risk of developing type 2 diabetes, even at a stage when normal glucose tolerance exists, and that factors in addition to insulin resistance may be operative.10480619
Glucose Intolerance (disease)Deregulated Nutrient SensingWomen had greater responses than men in both the micro- and macrovascular circulatory tests, but a similar progressive reduction was observed in both sexes with increasing degrees of glucose intolerance.10480619
Non-insulin Hypoglycemic, Hyperinsulinism, Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingThere is considerable evidence that insulin resistance with compensatory hyperinsulinaemia is an early and modifiable defect in the pathogenesis of non-insulin dependent diabetes (NIDDM).10480704
NEUROD1 wt AlleleDeregulated Nutrient SensingUsing a specific assay, we have addressed the hypothesis that an elevation of serum true insulin concentration, reflecting insulin resistance, is an early event in the pathogenesis of NIDDM.10480704
Hyperinsulinism, NEUROD1 wt AlleleDeregulated Nutrient SensingThese findings are consistent with the hypothesis that the majority of cases of adult onset NIDDM in this population are characterized by the early development of insulin resistance with compensatory true hyperinsulinaemia.10480704
Glucose Intolerance (disease), Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThese results suggest a dose-response relation of glucose intolerance at baseline with CHD incidence, CHD mortality, and total mortality, independent of other risk factors, in this cohort of middle-aged and older Japanese-American men.10480768
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingThere is substantial evidence that glucose intolerance is associated with an increased risk of cardiovascular disease.10480780
Gestational Diabetes, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of new criteria for type 2 diabetes on the rate of postpartum glucose intolerance in women with gestational diabetes.10486471
Gestational Diabetes, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingOur purpose was to determine the impact of the 1997 American Diabetes Association diagnostic criteria for type 2 diabetes mellitus on the rate of postpartum glucose intolerance in women with gestational diabetes.10486471
Mice, Inbred NOD, Insulin, diabeticDeregulated Nutrient SensingWe have previously shown that alterations of vagal control of heart rate variations are found in more than half of non diabetic obese subjects (Int J Obes 1995) and are associated with a more severe insulin resistance in noninsulin dependent diabetic patients (Metabolism 1998).10486673
Mice, Inbred NODDeregulated Nutrient SensingThe aim of this study was to examine whether parasympathetic alterations are also associated with a more severe insulin resistance in non diabetic obese subjects.10486673
Insulin resistance syndromeDeregulated Nutrient SensingThis data suggests that cardiac parasympathetic alterations should take part in the insulin-resistance syndrome and might account for the poor cardiovascular prognosis linked to this syndrome.10486673
Increased insulin level, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHowever insulin resistance is a common feature of obesity and essential hypertension, it is unclear if chronic hyperinsulinemia per se contributes to sympathetic overactivation.10486674
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingThe effects of dyslipidemia on left ventricular systolic function in patients with stable angina pectoris.10487494
Congestive heart failure, Dyslipidemias, Coronary Artery Disease, Heart failureDeregulated Nutrient SensingLarge-scale clinical trials have shown that long-term treatment with lipid-lowering therapy results in a significant reduction in the occurrence of heart failure among patients with coronary artery disease without previous evidence of congestive heart failure, suggesting dyslipidemia may have an adverse effect on left ventricular performance.10487494
HypertriglyceridemiaDeregulated Nutrient SensingInsulin resistance is associated with atherogenic lipoprotein phenotype, including small dense LDL particle, hypertriglycemia and low HDL cholesterol levels.10487503
Increased insulin levelDeregulated Nutrient SensingIn patients with insulin resistance syndrome, troglitazone improved the atherogenic lipoprotein phenotype as well as hyperinsulinemia.10487503
atheroscleroticDeregulated Nutrient SensingOur data suggest that troglitazone therapy could reduce the atherosclerotic risk due to insulin resistance even in non-diabetic patients.10487503
SyndromeDeregulated Nutrient SensingWe report here that antiinsulin receptor (anti-IR) autoantibodies (AIRs) from a newly diagnosed patient with type B syndrome of insulin resistance induced cellular resistance not only to insulin but also to insulin-like growth factor I (IGF-I) for the stimulation of phosphatidylinositol 3-kinase and mitogen-activated protein kinase activities and of glycogen and DNA syntheses.10487687
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance, exercise capacity and body composition in subjects with two hypertensive parents.10489104
Hypertension, CTCAEDeregulated Nutrient SensingTo study insulin resistance in subjects with strong genetic predisposition to essential hypertension, compared with non-disposed subjects.10489104
ObesityDeregulated Nutrient SensingIn the present study we have revealed that a specific combination of alleles in OB and OB-R, two candidate genes for obesity, may confer an increased risk for the development of insulin resistance in Nauruan males.10490782
Paresis, Traumatic injuryDeregulated Nutrient SensingSurgery and accidental trauma are associated with a transient period of insulin resistance, substrate catabolism and muscle weakness.10491345
ParesisDeregulated Nutrient SensingIn conclusion, the muscle weakness associated with post-operative insulin resistance is not related to a decreased specific tension or a loss of myofibrillar proteins.10491345
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine whether the serine/threonine kinase Akt (also known as protein kinase B) is activated in vivo by insulin administration in humans, and whether impaired activation of Akt could play a role in insulin resistance, we measured the activity and phosphorylation of Akt isoforms in skeletal muscle from 3 groups of subjects: lean, obese nondiabetic, and obese type 2 diabetic.10491408
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn these 405 patients, HbA1c was > or = 7% in 56.6%, and hypertension and dyslipidaemia were found in 59.8% and 46.5% of the patients, respectively.10493712
Obesity, Abdominal, Hyperinsulinism, DyslipidemiasDeregulated Nutrient SensingAssociations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males.10497620
Diabetes MellitusDeregulated Nutrient SensingFasting insulin levels in 30 patients with HCV-related cirrhosis and diabetes mellitus were elevated significantly, which was consistent with insulin resistance.10498660
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes, insulin resistance and dyslipidaemia in lipodystrophic HIV-infected patients on highly active antiretroviral therapy (HAART).10499191
Lipodystrophy, Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient SensingThus, lipodystrophy during HAART was associated with diabetes, insulin resistance and hypertriglyceridaemia.10499191
Diabetes MellitusDeregulated Nutrient SensingIncreased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance.10499882
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingAlthough most of patients with non-insulin-dependent diabetes mellitus (NIDDM) have insulin resistance, it is unknown whether a molecule might interfere with insulin action.10499882
NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, glycoprotein PC-1 activity of dermal fibroblasts is correlated with insulin resistance in patients with NIDDM.10499882
Diabetic NephropathyDeregulated Nutrient SensingTNF-alpha, IGF-I and leptin are agents which influence insulin resistance, they play probably a part in the pathogenesis of diabetic nephropathy and influence mutually their production.10510538
ObesityDeregulated Nutrient SensingInsulin resistance seems to be a metabolic aberration associated with obesity.10513036
ObesityDeregulated Nutrient SensingBody fat distribution, especially upper body segment obesity is related to insulin-resistance.10513036
Lipolysis, ObesityDeregulated Nutrient SensingAlso, the high rate of lipolysis present in obesity and in insulin resistance could lead to an impaired glucose oxidation in muscle.10513036
Non-insulin Hypoglycemic, Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, DiseaseDeregulated Nutrient SensingImpaired insulin action is also central to a cluster of diseases including non-insulin dependent diabetes, hypertension, dyslipidemias and atherosclerosis.10513036
Dyslipidemias, ObesityDeregulated Nutrient SensingMost of them were relatives of diabetics and/or themselves had obesity and/or dyslipidaemia.10520305
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, a third of the mothers with type 2 diabetes, and all but 1 of the siblings, had evidence of insulin resistance.10520614
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn addition, the incidence of diagnosed and undiagnosed type 2 diabetes or of insulin resistance in the families of adolescents with type 2 diabetes is striking.10520614
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThese findings raise the possibility that previously described relationships between soluble adhesion molecules in patients with hypertension, type 2 diabetes, and dyslipidemia may be due to the presence of insulin resistance in these clinical syndromes and suggests that insulin resistance may predispose individuals to coronary heart disease by activation of cellular adhesion molecules.10522984
Dyslipidemias, Kidney Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia and the progression of renal disease in chronic renal failure patients.10528663
Cancer-related fatigue, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia is common in patients with chronic renal failure (CRF), and there is increasing evidence to support the role of dyslipidaemia as a contributing factor in the progression of chronic renal disease.10528663
Proteinuria, Cancer-related fatigue, Dyslipidemias, Kidney Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingThese results suggest a limited role for dyslipidaemia in the progression of chronic renal disease to dialysis in CRF patients, in contrast with the powerful influence of proteinuria, baseline creatinine clearance and nephropathy type in predicting this progression.10528663
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIn univariate analysis we found a higher risk of AMI for men and women with hypertension, dyslipidaemia, diabetes and lower levels of education, for older women, for male smokers and for men with family histories of CHD.10534136
HD Term Type, DyslipidemiasDeregulated Nutrient SensingLow-molecular-weight heparin (LMWH) has been suggested as providing safe, efficient, convenient and possibly more cost-effective anticoagulation for haemodialysis (HD) than unfractionated heparin, with fewer side-effects and possible benefits on uraemic dyslipidaemia.10534515
Hypertensive (finding), Dyslipidemias, ObesityDeregulated Nutrient SensingObesity in hypertensive patients is associated with dyslipidemia and insulin resistance, both of which are improved by weight control.10539741
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Overweight, DiseaseDeregulated Nutrient SensingOverweight is accepted as risk factor for various diseases such as hypertension and diabetes mellitus, dyslipidemias and cardiovascular diseases.10540568
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance was found in six (10.4%) patients and diabetes mellitus in five (8.6%) patients in the TB group.10546470
Communicable Diseases, Glucose Intolerance (disease)Deregulated Nutrient SensingThe results suggest that glucose intolerance occurs in the setting of infection and is reversible following adequate antimicrobial treatment.10546470
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe purpose of this study was to investigate the association among insulin resistance, high density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD), and to test the hypothesis that HDL-C may ameliorate the adverse effects of insulin.10551691
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingA receiver operating characteristic (ROC) curve analysis indicated that HDL-C and insulin resistance were significant discriminators of CHD (area under ROC curve: 0.72 and 0.69, respectively).10551691
Increased insulin level, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe interaction between HDL-C and the association of insulin resistance with CHD was significant: subjects with hyperinsulinemia and high HDL-C had no increased risk of CHD.10551691
Hypoalphalipoproteinemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMultivariate conditional logistic regression analysis showed that hyperinsulinemic hypoalphalipoproteinemia was a stronger indicator for CHD than either HDL-C or insulin resistance alone (-2 log likelihood: 19.0 vs. 12.6 or 15.7).10551691
Increased insulin level, Hypoalphalipoproteinemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingHyperinsulinemic hypoalphalipoproteinemia was a more potent indicator for CHD than either insulin resistance or low serum HDL-C levels alone, and the adverse effects of hyperinsulinemia seem to be ameliorated by high HDL-C levels.10551691
ObesityDeregulated Nutrient SensingObesity, insulin resistance and disturbed glucose metabolism cluster within the Insulin Resistance Syndrome (IRS).10555133
Primary Hypothyroidism, Hyperprolactinemia, Adrenal cortical hypofunctionDeregulated Nutrient SensingThe patients also presented DM with insulin resistance, hyperprolactinemia, slight primary hypothyroidism and hypoadrenocorticism.10563749
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAssociation of nonalcoholic fatty liver disease with insulin resistance.10569299
Non-alcoholic Fatty Liver Disease, Obesity, Diabetes MellitusDeregulated Nutrient SensingWe tested the hypothesis that there is an association between nonalcoholic fatty liver disease and insulin resistance that is independent of diabetes and obesity.10569299
Increased insulin level, Hypoglycemia, Non-alcoholic Fatty Liver Disease, HypertriglyceridemiaDeregulated Nutrient SensingPatients with nonalcoholic fatty liver disease were characterized by fasting and glucose-induced hyperinsulinemia, insulin resistance, postload hypoglycemia, and hypertriglyceridemia.10569299
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance [odds ratio (OR) = 15 per percent increase, 95% confidence interval (CI): 3.0 to 70], fasting triglyceride level (OR = 3.1 per mmol/liter increase, 95% CI: 1.1 to 8.9), 180-minute blood glucose level (OR = 4.3 per mmol/ liter decrease, 95% CI: 1.6 to 12), and average insulin concentration in response to oral glucose (OR = 3.0 per 100 pmol/liter increase, 95% CI: 1.5 to 6.2) were independently associated with nonalcoholic fatty liver disease.10569299
Increased insulin level, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease is associated with insulin resistance and hyperinsulinemia even in lean subjects with normal glucose tolerance.10569299
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease is frequently associated with type 2 diabetes mellitus, obesity, and dyslipidemia, but some patients have normal glucose tolerance or normal weight.10569299
Hypertension, CTCAEDeregulated Nutrient SensingA close association between insulin resistance and dehydroepiandrosterone sulfate in subjects with essential hypertension.10580744
Hypertensive (finding)Deregulated Nutrient SensingSteady state plasma glucose was significantly higher in hypertensive subjects indicating insulin resistance compared with control subjects.10580744
ObesityDeregulated Nutrient SensingWe hypothesized that this variant may be associated with obesity and insulin resistance when combined with a westernized lifestyle.10582543
Cardiovascular DiseasesDeregulated Nutrient SensingLeptin is involved in the regulation of bodyweight and metabolism in man and might also be involved in the pathophysiology of the insulin resistance syndrome, which is associated with the development of cardiovascular diseases.10583712
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased glucose intolerance related to digoxin treatment in patients with type 2 diabetes mellitus.10583713
Endothelial dysfunctionDeregulated Nutrient SensingThe negative relationship between von Willebrand factor levels and glucose disposal in the low-risk group may indicate that insulin resistance can induce an endothelial dysfunction even in non-diabetic subjects.10583718
Weight GainDeregulated Nutrient SensingThis impaired GH secretion together with the clozapine-induced insulin resistance might be mechanisms behind weight gain during clozapine therapy.10584769
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient Sensing(a) To study whether there was an increased prevalence of glucose intolerance in the parents of probands with Type 1 diabetes and (b) to look for any possible link between the glucose intolerance in the parents with HLA-DQB1 alleles transmitted in excess to the Type 1 diabetes offspring.10585618
AtherosclerosisDeregulated Nutrient SensingInsulin resistance is associated with increased risk of atherosclerosis.10591678
Increased insulin level, Hyperparathyroidism, Glucose Intolerance (disease)Deregulated Nutrient SensingPatients with hyperparathyroidism have alterations in carbohydrate metabolism characterized by insulin resistance, hyperinsulinemia, and glucose intolerance.10598202
Kidney Failure, ChronicDeregulated Nutrient SensingImpact of dialysis therapy on insulin resistance in end-stage renal disease: comparison of haemodialysis and continuous ambulatory peritoneal dialysis.10607769
Uremia, AtherosclerosisDeregulated Nutrient SensingInsulin resistance contributes to the pathogenesis of atherosclerotic cardiovascular disease and, thus, has an important impact on the mortality of uraemic patients.10607769
UremiaDeregulated Nutrient SensingHaemodialysis (HD) is known to improve insulin resistance observed in uraemia.10607769
UremiaDeregulated Nutrient SensingHowever, it is not known whether continuous ambulatory peritoneal dialysis (CAPD) alleviates insulin resistance in adult uraemic patients.10607769
Uremia, HD Term TypeDeregulated Nutrient SensingThe objective of this study was to compare the effect of two different dialysis modalities, HD and CAPD, on insulin resistance in adult uraemic patients and to identify the possible predictive factors for changes in insulin resistance.10607769
Kidney Failure, Chronic, HD Term TypeDeregulated Nutrient SensingInsulin resistance was examined in 19 non-diabetic patients with end-stage renal disease (ESRD) before and after dialysis therapy (HD, n=10; CAPD, n=9), as well as in 10 healthy controls using the hyperinsulinaemic euglycaemic glucose clamp technique.10607769
HD Term Type, Coronary ArteriosclerosisDeregulated Nutrient SensingCAPD therapy, in spite of its possible adverse effects in patients with atherosclerotic disease, has been shown to improve insulin resistance in adult uraemic patients, similarly to HD therapy.10607769
Glucose Intolerance (disease), Acromegaly, Diabetes MellitusDeregulated Nutrient SensingAlthough growth hormone excess (acromegaly) in association with glucose intolerance and diabetes mellitus is well documented in adult medicine, it is much less common in the paediatric age group.10614552
ObesityDeregulated Nutrient SensingOur data suggest that among Eskimo people insulin resistance may be less prevalent or severe than among American Indians, but that obesity is associated with increased insulin resistance.10615832
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia may be an important contributor to this.10617243
NEUROD1 wt AlleleDeregulated Nutrient SensingPersons in the NIDDM and IGT groups had decreased beta cell function compared to persons in the NGT group, but did not have increased peripheral insulin resistance as estimated from the OGTT data.10619320
Increased insulin level, Hypertensive (finding), ObesityDeregulated Nutrient SensingOur data demonstrated that in this cohort of elderly hypertensive participants with a high prevalence of central obesity, impaired glycemic control was common, but was not associated with fasting hyperinsulinemia or peripheral insulin resistance.10619320
Glucose Intolerance (disease), Cardiovascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingIncreased risk for cardiovascular disease in persons with glucose intolerance (impaired glucose tolerance and type 2 diabetes mellitus) is not fully explained by concomitant elevations in traditional atherosclerosis risk factors.10634338
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingHyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function.10634338
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingHyperinsulinemia is associated primarily with impaired fibrinolysis in subjects with glucose intolerance.10634338
Increased insulin level, Glucose Intolerance (disease), Thrombosis, Cardiovascular DiseasesDeregulated Nutrient SensingExcess risk for cardiovascular disease associated with hyperinsulinemia and glucose intolerance may be mediated in part by enhanced potential for acute thrombosis.10634338
Weight GainDeregulated Nutrient SensingProspective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity.10643681
ObesityDeregulated Nutrient SensingEffect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man.10643689
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingPakistan National Diabetes Survey prevalence of glucose intolerance and associated factors in North West at Frontier Province (NWFP) of Pakistan.10646320
Diabetes MellitusDeregulated Nutrient SensingIn contrast, there was no association between insulin resistance and either autonomic function or the circadian rhythm of sympathovagal balance, regardless of diabetes status.10648499
Biliary calculi, Diabetes MellitusDeregulated Nutrient SensingWe hypothesized that insulin resistance rather than diabetes status may be a primary factor involved in gallstone formation.10655249
Hypertensive (finding)Deregulated Nutrient SensingBorderline hypertensive patients display normal glucose tolerance with basal insulin resistance and normal dynamic insulin sensitivity.10656171
Hypertension, CTCAEDeregulated Nutrient SensingBecause borderline hypertension often degenerates into overt disease, our results point to a progression that leads to the well-known insulin resistance proper to sustained hypertension.10656171
Glucose Intolerance (disease)Deregulated Nutrient SensingCross-sectional studies have demonstrated an association between high non-esterified fatty acid (NEFA) concentrations and glucose intolerance.10656229
Hyperglycemia, Attack behavior, DyslipidemiasDeregulated Nutrient SensingAssociation of dyslipidemia with hyperglycemia, the high level of lipidic peroxides and the diminution of body capacity of annihilating them, actually represents an increase in risk factors for onset of vascular attacks.10660970
Obesity, Abdominal, ObesityDeregulated Nutrient SensingBirth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances.10663216
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe insulin resistance syndrome was defined as the combination of hypertension, insulin resistance and dyslipidaemia.10663216
Obesity, Abdominal, Dyslipidemias, ObesityDeregulated Nutrient SensingLow birth weight predicts high blood pressure, insulin resistance, truncal obesity and high plasminogen activator inhibitor-1 activity but not the abdominal obesity or dyslipidaemia present in the insulin resistance syndrome.10663216
DysgeusiaDeregulated Nutrient SensingThe cluster of disturbances associated with low birth weight is a subset of the disturbances that are clustered in the general population as the insulin resistance syndrome.10663216
Presenile dementia, DyslipidemiasDeregulated Nutrient SensingThe effect of APOE on dementia may be mediated through dyslipidemia and atherogenesis through its effect on cholesterol metabolism.10668701
Presenile dementia, Dyslipidemias, Data types - AddressDeregulated Nutrient SensingPresence of APOE epsilon4/* seems to increase the risk for dementia and AD independently of its effect on dyslipidemia and atherogenesis.10668701
DyslipidemiasDeregulated Nutrient SensingThe "classic" risk factors--like dyslipidemia--are not always present in significant percentages in patients suffering from PAOD of the lower limbs.10670255
Atherosclerosis, NEUROD1 wt Allele, Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to clarify whether insulin resistance contributes to atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM).10670747
Cutaneous plaque, AtherosclerosisDeregulated Nutrient SensingThese data suggest that insulin resistance in the peripheral tissues but not the splanchnic tissues may independently contribute to carotid arterial wall thickness and especially to plaque lesion, and that habitual exercise might reduce insulin resistance leading to attenuation of atherosclerosis.10670747
Premenopause, Antihypertensive AgentsDeregulated Nutrient SensingThe hypothesis to be tested in hypertensives was that men have more pronounced insulin resistance and other cardiovascular risk factors than pre-menopausal, but not post-menopausal, women.10673732
Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Malignant Neoplasms, Obesity, Hypertension, CTCAE, DiseaseDeregulated Nutrient SensingObesity greatly increases the risks of developing diseases, including diabetes mellitus, hypertension, dyslipidaemia, coronary artery disease, and some cancers.10673848
Obesity, AbdominalDeregulated Nutrient SensingThis clustering is attributed to an insulin resistance syndrome promoted by abdominal obesity.10678282
Hypertension, CTCAEDeregulated Nutrient SensingRelative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension.10678546
Hypertensive disease, Hyperinsulinism, Muscle hypertrophyDeregulated Nutrient SensingHigh systolic blood pressure was related to vascular hypertrophy, whereas hyperinsulinaemia and insulin resistance were not, suggesting that longstanding high blood pressure is a far more important determinant for structural vascular changes than insulin resistance at this stage of the hypertensive disease.10678546
Hypertensive (finding), HyperinsulinismDeregulated Nutrient SensingHowever, hyperinsulinaemia and insulin resistance were associated with low distensibility of the common carotid arteries in the subgroup of never treated hypertensive patients.10678546
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThese results suggest that higher plasma IRI levels and/or insulin resistance are closely related to the pathogenesis of hypertension in patients with diabetes mellitus.10678547
Uremia, DyslipidemiasDeregulated Nutrient SensingUnderstanding the mechanism(s) of elevated apoC-III in uremia may help to clarify the causes of uremic dyslipidemia.10681649
Gestational Diabetes, Glucose Intolerance (disease)Deregulated Nutrient SensingWomen diagnosed with GDM who have unrecognized Type 2 DM are also at high risk, but perinatal mortality is low in women with milder degrees of glucose intolerance in pregnancy.10691157
Cushing Syndrome, Hypertension, CTCAEDeregulated Nutrient SensingRecent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.10692082
ObesityDeregulated Nutrient SensingIncreasing obesity and plasma cortisol concentrations make independent and sex-specific contributions to variations in blood pressure and aspects of the insulin resistance syndrome.10692082
Hyperhomocysteinemia, Coronary Artery DiseaseDeregulated Nutrient SensingHyperhomocysteinemia as well as insulin resistance are considered to be risk factors for the development of coronary artery disease.10692093
Hypertensive (finding)Deregulated Nutrient SensingHowever, a 2-h clamp results in lower insulin sensitivity values in elderly, hypertensive patients due to the fact that steady state is not reached, demonstrating a higher prevalence of insulin resistance in such a population.10697300
Diabetes MellitusDeregulated Nutrient SensingWe examined the effect of an oleic-acid-rich diet on insulin resistance and endothelium-dependent vasoreactivity in type 2 diabetes.10700478
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingChange from polyunsaturated to monounsaturated diet in type 2 diabetes reduced insulin resistance and restored endothelium-dependent vasodilatation, suggesting an explanation for the anti-atherogenic benefits of a Mediterranean-type diet.10700478
ObesityDeregulated Nutrient SensingInsulin resistance, a well-known feature of obesity, is associated with several pathological changes, which are potentially arrhythmogenic.10701717
Premature ventricular contractions, ventricular massDeregulated Nutrient SensingIt appears that in obese normotensive subjects, ventricular ectopic beats are related to age, insulin resistance, left ventricular mass index, and decreased intracellular magnesium content.10701717
Coronary Artery DiseaseDeregulated Nutrient SensingSerum N-acetyl-beta-D-gulucosaminidase activity increases in association with insulin resistance in patients with coronary artery disease.10704622
Coronary Artery DiseaseDeregulated Nutrient SensingOur results suggested that serum NAG activity correlates with the severity of coronary artery disease in relation to plasma insulin level and insulin resistance, and thus can be an indicator of coronary artery disease based upon abnormalities of glucose metabolism.10704622
Hyperlipidemia, Cardiovascular Diseases, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIt is well known that obesity is closely related to non-insulin-dependent diabetes mellitus, hyperlipidemia, hypertension and cardiovascular disease, and the insulin resistance associated with obesity is supposed to play a central role for the development of these diseases.10704695
Obesity, HostilityDeregulated Nutrient SensingThe results are consistent with those of prior research and also suggest that, in older men, hostility may be associated with a pattern of obesity, central adiposity, and insulin resistance, which can exert effects on blood pressure and serum lipids.10705906
Coronary heart disease, diabeticDeregulated Nutrient SensingLDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: The Strong Heart Study.10712410
Dyslipidemias, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingThus, even at concentrations well below the National Cholesterol Education Program target of 130 mg/dL, LDL cholesterol is a strong independent predictor of coronary heart disease in individuals with diabetes, even when components of diabetic dyslipidemia are present.10712410
diabeticDeregulated Nutrient SensingIncreased urinary albumin excretion (UAE) in diabetic and nondiabetic subjects is frequently associated with insulin resistance syndrome and central obesity.10718833
Cushing SyndromeDeregulated Nutrient SensingCushing's syndrome is also characterized by central obesity and insulin resistance.10718833
daytime sleepiness, Sleep Apnea, CTCAE, Obesity, Visceral, FatigueDeregulated Nutrient SensingSleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia.10720054
Apnea, ObesityDeregulated Nutrient Sensing3) Is apnea a factor independent from obesity in the development of insulin resistance?10720054
Obesity, Visceral, Sleep Apnea, CTCAE, Sequela of disorderDeregulated Nutrient SensingWe conclude that there is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition.10720054
Primary malignant neoplasm, Glucose Intolerance (disease)Deregulated Nutrient SensingOver the 4 h feeding period, changes in insulin and glucose concentrations in cancer patients suggested relative glucose intolerance.10731472
Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn patients with the clinical syndrome of insulin resistance--defined as diabetes, hypertension, and obesity--mortality was reduced by abciximab treatment from 5.1% to 2.3%, p = 0.044.10732889
Dyslipidemias, Premature coronary artery atherosclerosisDeregulated Nutrient SensingHereditary dyslipidemias and combined risk factors in children with a family history of premature coronary artery disease.10735834
Premature coronary artery atherosclerosis, DyslipidemiasDeregulated Nutrient SensingSchoolchildren aged 10-11 with a family history of premature coronary artery disease (CAD), were examined in order to identify children with genetically determined dyslipidemias and a combination of risk factors.10735834
Hyperlipidemia, Hypercholesterolemia, Dyslipidemias, Family history, HereditaryDeregulated Nutrient SensingOf the remaining 38 children, 23 had non-hereditary abnormalities of low (LDL) or high density lipoprotein (HDL) cholesterol or apolipoprotein B. Fifteen children were suspected to have genetically determined dyslipidemias or a combination of risk factors: in four, possible familial hypercholesterolaemia (FH); in five, possible familial combined hyperlipidaemia; in three, hereditary low HDL cholesterol; and in three a combination of high LDL cholesterol and Lp(a) lipoprotein concentrations.10735834
Glucose Intolerance (disease), Acromegaly, Has difficulty doing (qualifier value)Deregulated Nutrient SensingOur data confirm that in acromegalic patients: airway difficulties occurred more frequently; severe haemodynamic instability did not typically occur during surgery for acromegaly; pulmonary gas exchange was not altered during operation; glucose intolerance may be an intraoperative problem; and fluid regulation may be altered.10743450
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingMain risk factors (cholesterol, smoking, systolic blood pressure, glucose intolerance and diabetes) could only explain one third of this gradient.10746111
ObesityDeregulated Nutrient SensingInsulin resistance, 2 h plasma glucose, insulin and obesity aggregated as the major domain.10746487
Glucose Intolerance (disease), Cirrhotic, shunt occlusionDeregulated Nutrient SensingThese results indicate that decreased portal flow due to extrahepatic shunt and consequent impairment of insulin metabolism play a role in glucose intolerance observed in cirrhotic patients and that shunt occlusion improves glucose metabolism.10749336
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingA study was undertaken in order to determine if hypertension in Bahrainis is associated with the same factors as those related to glucose intolerance.10750606
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThe age-adjusted prevalence of hypertension (defined as current treatment for hypertension, systolic blood pressure > or = 160 mmHg or diastolic blood pressure > or = 95 mmHg) rose with increasing degrees of glucose intolerance.10750606
Increased insulin levelDeregulated Nutrient SensingThese results show that small size at birth is associated with increased insulin resistance and hyperinsulinemia in young adult life but that these relationships are restricted to the male gender in this age group.10751205
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPravastatin compared to bezafibrate in the treatment of dyslipidemia in insulin-treated patients with type 2 diabetes mellitus.10751747
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBoth HMG-CoA reductase inhibitors and fibric acid derivates are used for the treatment of dyslipidemia in Type 2 diabetes patients.10751747
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingThe independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear.10753036
AnemiaDeregulated Nutrient SensingOur study proves the beneficial effect of EPO treatment on insulin resistance in dialysis patients which could be attributed to the EPO itself and not to the correction of anaemia and is accompanied by improvement in triglyceride levels.10754408
Hypertension, CTCAE, Myocardial Ischemia, DyslipidemiasDeregulated Nutrient SensingThe most frequent vascular risk factors were hypertension (42%), smoking (64%), and dyslipidemia (52%); 30% had previous ischemic heart disease.10763352
First Degree Relative, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEndothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance.10769277
Increased insulin level, AtherosclerosisDeregulated Nutrient SensingAmong the pathogenetic factors leading to atherosclerosis, the role of insulin resistance and hyperinsulinemia as independent risk factors is still under debate.10769277
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this study, we examined the association between ED and insulin resistance in normotensive and normoglycemic first-degree relatives (FDRs) of patients with type 2 diabetes mellitus (DM).10769277
Demographics DomainDeregulated Nutrient SensingThere is a significant association between ED and insulin resistance in young FDRs of DM subjects independent of the classic cardiovascular risk factors.10769277
Fetal Growth RetardationDeregulated Nutrient SensingInsulin resistance early in adulthood in subjects born with intrauterine growth retardation.10770173
Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingMild-to-severe hypertension was found in 24 of 50 (48%) patients, type-2 diabetes in 12 of 50 (24%), and glucose intolerance in 6 of 50 (12%) patients.10770179
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin-like growth factor I (IGF-I) is an important regulator of many aspects of growth, differentiation, and development, and as low birth weight has been associated with impaired glucose tolerance and overt type 2 diabetes in adult life, we considered the genes encoding the IGF-I and the IGF-I receptor (IGF-IR) as candidates for low birth weight, insulin resistance, and type 2 diabetes.10770205
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance was demonstrated in hypertensive patients and in salt-sensitive subjects.10775552
Hypertension, CTCAEDeregulated Nutrient SensingThese results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension.10775552
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSince this amino acid substitution may cause a reduction in the transcriptional activity of PPARgamma, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes.10777704
NEUROD1 wt AlleleDeregulated Nutrient SensingFrom this model springs the inference that NIDDM is a cumulative dyslipidaemia-over-time process.10777986
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingDespite assuming that obesity and insulin resistance precedes DM, FFQ may not be useful in the assessment of unfavorable dietary patterns among subjects at risk for glucose intolerance, such as Japanese-Brazilians with elevated BMI.10778035
Tumor necrosis, Non-insulin Hypoglycemic, Diabetes MellitusDeregulated Nutrient SensingGLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity.10778531
Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingHence, it is likely that there is a close interaction between GLUT-4, TNF-alpha, EFAs, daf-genes, melatonin and leptin that may have relevance to the development of insulin resistance, obesity, NIDDM, complications due to NIDDM, longevity and ageing.10778531
diabeticDeregulated Nutrient SensingEffects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients.10781642
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingTherefore, although the individual risk of hypertriglyceridemia is increased in women with the haplotype T, C at -482, -455, it appears that the -482, -455 and SstI APOC-III gene polymorphisms are not major contributors to the risk of dyslipidemia in the population of northern France.10781646
Dyslipidemias, diabeticDeregulated Nutrient SensingType 2 diabetic patients exhibited the classical dyslipidemia of the insulin resistance syndrome and delayed clearance of both hepatic and intestinal particles.10781648
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingThe association between angiotensin-converting enzyme (ACE) as well as apolipoprotein B polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial.10781757
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAtorvastatin for the management of Type 2 diabetic patients with dyslipidaemia.10782562
TG gene, Cardiac complication, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia, particularly increased triglycerides (TG) and low HDL-cholesterol (HDL-C), represents an important risk factor for Type 2 diabetes (T2DM) macrovascular complications.10782562
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe sensitivity for detecting dyslipidemia was generally higher for abdominal obesity, based on either WHR or WC, than for criteria based on the other risk factors under study.10785570
HypertriglyceridemiaDeregulated Nutrient SensingBody mass index, insulin resistance, mutations in other candidate genes (Asn291Ser and Asp9Asn in the LPL gene, apoE isoforms, polymorphisms in the apoA-II gene and in the apoAI-CIII-AIV gene cluster, and in the IRS-1 gene) could be ruled out as possible factors contributing to the expression of hypertriglyceridemia in this family.10787434
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThis relationship was largely explained by obesity, hypertension, and dyslipidemia.10789610
AcromegalyDeregulated Nutrient SensingAlthough insulin resistance is a common feature of acromegaly, it remains unclear whether the extent of insulin resistance per se determines the abnormal glucose tolerance.10792333
HyperglycemiaDeregulated Nutrient SensingSeveral other questions remain open due to scanty informations on LDL-concentrations, and a complete lack of data concerning insulin/insulin resistance, hyperglycemia, respectively.10802893
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingAssociation between angiotensin-converting enzyme (ACE) as well as apolipoprotein (apo) AI, B, and E polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial.10803441
Metabolic Diseases, ObesityDeregulated Nutrient SensingAccordingly, it is suggested that evaluating Pmax by ultrasonography may be the most sensitive and reliable method of predicting insulin resistance-associated metabolic derangements in children, compared with other conventional indices of obesity.10804731
Coronary ArteriosclerosisDeregulated Nutrient SensingThese results suggest that there is an association between high insulin resistance and coronary vascular endothelial cell dysfunction, and that insulin resistance may be an indicator of early stage coronary artery atherosclerosis not detectable by angiography.10806013
Glucose Intolerance (disease)Deregulated Nutrient SensingIn Wadena, glucose intolerance increased sharply among the obese.10808062
Insulin resistance - type ADeregulated Nutrient SensingThe type B insulin-resistance syndrome is characterized by the presence of anti-insulin receptor antibodies that cause severe insulin resistance.10808065
HypersensitivityDeregulated Nutrient SensingWe describe a patient with type B insulin resistance syndrome who was treated successfully with human recombinant (hr) IGF-1, although this treatment provoked a severe allergic reaction.10808065
Insulin resistance - type ADeregulated Nutrient SensingThe patient was diagnosed with type B insulin-resistance syndrome by the presence of anti-insulin receptor antibodies.10808065
Increased insulin level, Hypertriglyceridemia, Obesity, AtherosclerosisDeregulated Nutrient SensingCentral body fat distribution has been shown to be related to hyperinsulinemia, insulin resistance, hypertriglyceridemia, and atherosclerosis to a greater degree than general obesity.10808240
DyslipidemiasDeregulated Nutrient SensingBezafibrate and simvastatin combination therapy for diabetic dyslipidaemia: efficacy and safety.10809995
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingReverse correlation between urine nitric oxide metabolites and insulin resistance in patients with type 2 diabetes mellitus.10811296
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe studied the possible relationship between nitric oxide (NO) production and insulin resistance in patients with type 2 diabetes mellitus.10811296
diabeticDeregulated Nutrient SensingGlucose infusion rate (GIR) was measured as a reverse index for insulin resistance by euglycemic glucose clamp study using an artificial pancreas in 20 of 102 diabetic patients.10811296
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings suggest that NO production is closely related with insulin resistance in patients with type 2 diabetes.10811296
Hypertriglyceridemia, Hypoalphalipoproteinemia, FamilialDeregulated Nutrient SensingHypertriglyceridemia and low high density lipoprotein-cholesterol (HDLc) seem to be related with insulin resistance.10812581
Alzheimers Disease", Apolipoprotein E, Data types - AddressDeregulated Nutrient SensingHigher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele.10818510
Hypertension, CTCAEDeregulated Nutrient SensingCorrelative factors of insulin resistance in essential hypertension.10821137
Hypertension, CTCAE, metabolic disturbanceDeregulated Nutrient SensingEssential Hypertension (EH) is correlated with a metabolic disturbance characterized by insulin resistance (IR).10821137
Carotid Intima-Media ThicknessDeregulated Nutrient SensingRelation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects.10821297
Carotid Intima-Media Thickness, Cardiovascular DiseasesDeregulated Nutrient SensingTo assess whether there is an association between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects free from symptomatic cardiovascular disease.10821297
Hypertension, CTCAE, Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingIt is concluded that the association between insulin resistance, as assessed by the HOMA method in non-diabetic subjects, and atherosclerosis is explained by its covariance with established risk factors for cardiovascular disease of which hypertension seems to be the most significant.10821297
Hypertensive (finding), Hypertension, CTCAE, Glucose Intolerance (disease)Deregulated Nutrient SensingTo compare the muscle morphology in hypertensive subjects with that in controls and to test the hypothesis of a relation between heart rate, development of hypertension and muscle morphology that is independent of glucose intolerance.10826558
Retinal Diseases, Complications of Diabetes MellitusDeregulated Nutrient SensingThese results suggest that an abnormal fibrinolytic state, especially overproduction of PAI-1, may be a pathogenic factor in the development of diabetic complications such as retinopathy, which may be improved by correction of the insulin resistance with troglitazone.10831180
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingObesity is a major risk factor for cardiovascular disease frequently associated with hypertension, dyslipidemia, and diabetes.10831182
HypercholesterolemiaDeregulated Nutrient SensingReport of the Working Group on Hypercholesterolemia and Other Dyslipidemias.10834048
physiopathologicalDeregulated Nutrient SensingIslet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance.10834425
Apolipoprotein EDeregulated Nutrient SensingApolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study.10834428
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance and the apolipoprotein (apo) allele e4 have both been associated with coronary heart disease (CHD).10834428
Autoimmune reactionDeregulated Nutrient SensingMoreover, it can also suggest that both autoimmune insulitis and insulin resistance may coexist in parallel.10838742
Chronicity, DyslipidemiasDeregulated Nutrient SensingThe reduction of the E-selectin plasma levels was proportional to the values of total cholesterol and triglycerides; the chronicity and the dyslipidemia may be responsible for the basal diminished biosynthetic endothelial function; in the severe hypercholesterolemics the lipid-lowering treatment caused a significant decrease of E-selectin, due to a probable reduced endothelial irritation dependent on the hyperlipemic stress.10838833
Ventricular hypertrophyDeregulated Nutrient SensingLeft ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men.10840010
Antihypertensive AgentsDeregulated Nutrient SensingAssociations between left ventricular (LV) geometry and the insulin resistance syndrome have been found, mostly in small studies of middle-aged hypertensives.10840010
HypertrophyDeregulated Nutrient SensingSeveral components of the insulin resistance syndrome were related to thick LV walls and concentric remodeling but less to LV hypertrophy in this population-based sample of elderly men.10840010
Demographics DomainDeregulated Nutrient SensingWe conclude that this gene abnormality does not play a role in the pathogenesis of insulin resistance and type-2 DM.10844412
Non-insulin Hypoglycemic, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA study of dyslipidemia and platelet adhesiveness in non-insulin dependent diabetes mellitus.10846630
Dyslipidemias, Obesity, Arteriopathic diseaseDeregulated Nutrient SensingObesity, dyslipidemia and increased platelet adhesiveness are interconnected and make diabetics more susceptible to arterial disease with increased risk of vascular episodes.10846630
PancreasDeregulated Nutrient SensingReduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels.10852463
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus is associated with insulin resistance, reduced B cell function, and an increase in the proinsulin (PI) to immunoreactive insulin (IRI) ratio (PI/IRI); the latter is thought to be an indication of B cell dysfunction.10852463
Increased insulin level, Endometrial CarcinomaDeregulated Nutrient Sensing[The nature of hyperinsulinemia (insulin resistance) in endometrial carcinoma: of plasma levels of insulin and c-peptide].10853419
Increased insulin level, Endometrial CarcinomaDeregulated Nutrient SensingObese (BMI index 28 kg/m2) reproductive endometrial carcinoma patients showed pronounced hyperinsulinemia and resistance to insulin.10853419
Iron deficiency anemiaDeregulated Nutrient Sensing[Unusual cause of chronic iron-deficiency anemia and insulin resistance: cholesterol embolism].10855367
AnemiaDeregulated Nutrient SensingA 73 year-old female patient developed CED disclosed by iron deficiency anemia with chronic digestive bleeding associated with major insulin resistance.10855367
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingInsulin resistance has not been reported although prior diabetes is often mentioned as a predisposing factor for atherosclerosis.10855367
Arterial Stiffness, diabeticDeregulated Nutrient SensingThe insulin resistance syndrome is related to arterial stiffness in diabetic subjects.10855542
Arterial StiffnessDeregulated Nutrient SensingWhether the insulin resistance syndrome is also related to arterial stiffness in non-diabetic subjects is less clear.10855542
Hypertension, CTCAE, Endothelial dysfunctionDeregulated Nutrient SensingA possible link between endothelial dysfunction and insulin resistance in hypertension.10855737
Atherosclerosis of renal artery, Coronary Artery Disease, diabetic, AtherosclerosisDeregulated Nutrient SensingCarotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study).10856382
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPatients with dyslipidemia are at increased risk of coronary heart disease (CHD), while treatment to reduce low density lipoprotein cholesterol (LDL-C) concentrations lessens this risk.10856770
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur prospective findings are consistent with previous, mainly cross-sectional reports, suggesting that low levels of testosterone and SHBG play some role in the development of insulin resistance and subsequent type 2 diabetes.10857940
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRosiglitazone is a potent peroxisome proliferator-activated receptor gamma agonist that decreases hyperglycemia by reducing insulin resistance in patients with type 2 diabetes mellitus.10859151
Vascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIf present, this association may be modified by diabetes, which is also associated with dyslipidemia that predisposes to macrovascular disease.10861896
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe dyslipidemia in present study not correlate with the risk of developing cardiovascular disease reinforcing the earlier finding of increased levels of HDL-c at higher altitudes.10862268
ObesityDeregulated Nutrient SensingThese results suggest that the degree of clustering of risk variables of Syndrome X varies with age from childhood to adulthood and is likely influenced by the age-related changes in obesity and the attendant insulin resistance.10866058
Kidney Failure, Chronic, Arteriosclerosis, DyslipidemiasDeregulated Nutrient SensingElevated plasma homocysteine (Hcy), dyslipidemia and hemorheological abnormalities all occur commonly in end-stage renal disease (ESRD) and are recognized risk factors for arteriosclerosis.10867536
Increased insulin levelDeregulated Nutrient SensingThe goal of this study was to define the relationship between a quantitative measure of the ability of physiological hyperinsulinemia to stimulate glucose disposal and several surrogate measures of insulin resistance.10868826
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingTime trends in testing for glycemic test and control and screening for dyslipidemia, use of lipid-lowering drugs, and microalbuminuria were evaluated as measures of care process.10868830
Obesity, diabeticDeregulated Nutrient SensingReduced beta-cell compensation to the insulin resistance associated with obesity in members of caucasian familial type 2 diabetic kindreds.10868835
Increased insulin level, Glucose Intolerance (disease), HyperglycemiaDeregulated Nutrient SensingTransgenic mice exhibit fasting hyperglycemia and hyperinsulinemia and glucose intolerance in later life, indicating an age-related decline in glucocompetence.10868969
Increased insulin levelDeregulated Nutrient SensingSex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children.10870035
Coronary heart diseaseDeregulated Nutrient SensingHigh triglyceride associated with reduced HDL, indicating insulin resistance and small dense LDL, was shown to be associated with excess coronary disease.10872616
Weight GainDeregulated Nutrient SensingAll the risk factors tended to cluster, and this was shown to be promoted by insulin resistance induced by weight gain.10872616
Cardiovascular DiseasesDeregulated Nutrient SensingThe Framingham Study is now engaged in quantifying the independent contributions of homocysteine Lp(a), insulin resistance, small dense LDL, C reactive protein, clotting factors and genetic determinants of cardiovascular disease.10872616
Inflammation, AtherosclerosisDeregulated Nutrient SensingChronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).10880413
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingOf CD1 mice fed with betel-nut or associated nitrosamines 8.5% develop glucose intolerance with marked obesity.10884715
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRole of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with non-insulin-dependent diabetes mellitus.10888395
NEUROD1 wt AlleleDeregulated Nutrient SensingAlthough elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-D-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial.10888395
Skeletal muscle structure, NEUROD1 wt AlleleDeregulated Nutrient SensingInsulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM.10888395
Glucose Intolerance (disease), Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe family history of diabetes (RR 10.1; IC95% 2.7-15.8, p < 0.01), glucose intolerance (RR 9.8; IC95% 1.7-13.4, p < 0.01), abdominal obesity (RR 6.1; IC95% 1.5-10.1, p < 0.01), and the low FG/I ratio and high IL 2-h PG (RR 3.3; IC95% 1.4-8.2, p < 0.05) were strong predictors for type 2 diabetes.10893848
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingG-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia.10894818
ObesityDeregulated Nutrient SensingFurther, black offspring of both diabetics and non-diabetics had unfavorable profiles of obesity and abdominal fat measures, blood pressure, insulin, and insulin resistance index (P = 0.0001).10896837
Diabetes MellitusDeregulated Nutrient SensingInsulin (P = 0.0001) and the insulin resistance index (P = 0.0001) were independently associated with conditions of impaired fasting glucose or type 2 diabetes.10896837
Williams Syndrome, Diabetes MellitusDeregulated Nutrient SensingOur results indicate that insufficient insulin secretion, which could not overcome insulin resistance, might play a crucial role in the pathophysiology and progression of diabetes in WS along with insulin resistance due to a post-receptor defect.10898130
HyperuricemiaDeregulated Nutrient SensingPhysical activity was associated with serum insulin level and with factors associated with insulin, ie, heart rate, hyperuricemia, diastolic blood pressure, and high-density lipoprotein cholesterol level, and with gamma-glutamyltransferase level, a possible marker of hepatic insulin resistance.10904453
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance and diabetes mellitus are associated with physical inactivity, but it is unclear whether preventive interventions should aim at increasing overall energy expenditure or increasing participation in vigorous, fitness-enhancing activities.10909950
Increased insulin levelDeregulated Nutrient SensingExposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance.10911003
Tumor necrosisDeregulated Nutrient SensingPrevious studies have demonstrated a role for tumor necrosis factor-alpha (TNF-alpha) in insulin resistance.10916281
AtherosclerosisDeregulated Nutrient SensingSince the IMT-CCA is an earlier asymptomatic sign of atherosclerosis, this study indicates that insulin resistance per se may accelerate atherogenesis.10918528
diabeticDeregulated Nutrient Sensing[Alteration of fatty acid components of erythrocyte membrane and insulin resistance in diabetic patients].10923482
NEUROD1 wt AlleleDeregulated Nutrient SensingTo study the effect of alteration of erythrocyte membrane fatty acid components and fluidity on insulin resistance (ISR) in NIDDM patients.10923482
Hyperlipidemia, USF1 wt AlleleDeregulated Nutrient SensingDyslipidemias and insulin resistance often present simultaneously, as in familial combined hyperlipidemia (FCHL), and therefore may have a common genetic background.10924736
Hyperlipidemia, USF1 wt AlleleDeregulated Nutrient SensingWe conclude that the Ala12 isoform of PPARgamma2 ameliorates the insulin resistance and unfavorable lipid and lipoprotein profiles in FCHL and hyperlipidemic elderly subjects.10924736
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingThe Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.10924736
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingTherefore, 228 nondiabetic members of FCHL families and 866 nondiabetic elderly subjects with (n=217) and without dyslipidemia (n=649) were genotyped.10924736
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingThe allele frequencies of the Pro12A1a substitution did not differ between elderly subjects with or without dyslipidemia or 27 probands with FCHL.10924736
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingHowever, this substitution was associated with low fasting insulin levels both in FCHL family members (P = 0.036 adjusted for gender and age) and elderly subjects with dyslipidemia (P=0.050) but not in elderly subjects without dyslipidemia (P=0.080).10924736
DyslipidemiasDeregulated Nutrient SensingIn addition, the Ala12 allele of PPARgamma2 was associated with low BMI (P= 0.034) and low total triglycerides (P=0.027), and increased HDL-cholesterol (P < 0.001) in elderly subjects with dyslipidemia (n=299) but not among any other study groups.10924736
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance in peripheral tissues, increased hepatic gluconeogenesis, and impaired insulin secretion are the underlying factors in the development of type 2 diabetes.10929918
DyslipidemiasDeregulated Nutrient SensingCardiac transplant patients are at increased risk of dyslipidemia, a known pathogenetic factor in chronic rejection.10930822
Glucose Intolerance (disease)Deregulated Nutrient SensingThese mice showed severe insulin resistance and glucose intolerance from an early age.10932232
Coronary heart diseaseDeregulated Nutrient SensingAssociations between lipoprotein lipase gene polymorphisms and insulin resistance in coronary heart disease.10934810
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingVariants of the LPL gene (Pvu II and Hind III polymorphisms) may increase the risk of developing coronary heart disease (CHD) but their effect on insulin resistance remains unknown.10934810
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingWe suggest that the LPL gene Hind III allele might be associated with insulin resistance in nondiabetic men with CHD.10934810
Increased insulin level, Hypertriglyceridemia, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMMS was defined as the occurrence of two or more of either hypertension, type 2 diabetes mellitus, dyslipidemia, hypertriglyceridemia or hyperinsulinemia.10942873
Tumor necrosisDeregulated Nutrient SensingTumor necrosis factor-alpha (TNFalpha) and its soluble receptor 2 (TNFR2) are expressed in adipose tissue and are possibly involved in the pathogenesis of insulin resistance.10946872
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingReduced size at birth has been proposed to be a risk factor for insulin resistance and type 2 diabetes.10946909
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe prevalences of hypertension, dyslipidemia, diabetes mellitus, cigarette smoking and obesity were determined in both sexes and compared using the chi-square test.10951822
Diabetes MellitusDeregulated Nutrient SensingThe Nagoya-Shibata-Yasuda (NSY) mouse closely mimics human Type II (non-insulin-dependent) diabetes mellitus in that the onset is age-dependent, the animals are not severely obese, and both insulin resistance and impaired insulin response to glucose contribute to disease development.10952468
ObesityDeregulated Nutrient SensingPlasma leptin has been shown to correlate positively with many indices of obesity, as well as insulin resistance.10954026
diabeticDeregulated Nutrient SensingThese results suggest that serum ferritin can be employed as a marker of not only glucose homeostasis but also insulin resistance both in type 2 diabetic and control subjects.10957894
Demographics Domain, Diabetes Mellitus, Beta-Cell Function MeasurementDeregulated Nutrient SensingImpaired glucose tolerance (IGT) and diabetes mellitus (DM) were associated with greater insulin resistance and impaired beta-cell function compared to normal glucose tolerance (NGT).10963828
Dyslipidemias, ObesityDeregulated Nutrient SensingAlternative training programs should be considered to maximize caloric expenditure and modify specific risk factors such as obesity and dyslipidemia.10966557
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe present study shows that, although the Q allele of the human glycoprotein PC-1 gene is associated with surrogate measures of insulin resistance, it may not be enough to increase the susceptibility to type 2 diabetes.10969847
Diabetes MellitusDeregulated Nutrient SensingThe K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians.10969849
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, the K121Q polymorphism of the human PC-1 gene is not associated with type 2 diabetes or insulin resistance among Danish Caucasians.10969849
Dyslipidemias, diabeticDeregulated Nutrient SensingAtorvastatin, a known substrate of the CYP3A4 pathway, is often used in combination with troglitazone for diabetic patients with dyslipidemia.10971778
Impaired T cell function, Family historyDeregulated Nutrient SensingSubjects with 'both' IGT and FH had features of insulin resistance (higher BMI, systolic and diastolic blood pressure and triglyceride concentration) as well as beta cell dysfunction with a lower % B and 30 min insulin-glucose ratio compared to controls.10975211
AtherosclerosisDeregulated Nutrient SensingCigarette smoking, environmental tobacco smoke exposure and insulin sensitivity: the Insulin Resistance Atherosclerosis Study.10976855
AtherosclerosisDeregulated Nutrient SensingInsulin sensitivity and tobacco use history were measured in 1481 participants in the Insulin Resistance Atherosclerosis Study (IRAS).10976855
Cardiovascular Diseases, Dyslipidemias, Nephrotic Syndrome, Abnormality of the peripheral nervous system, Retinal DiseasesDeregulated Nutrient SensingClinical abnormalities included peripheral and central nervous system abnormalities as well as retinopathy, dyslipidemia, cardiovascular disease, and nephrotic syndrome.10977796
Dyslipidemias, ObesityDeregulated Nutrient SensingThis article details the dyslipidemia of obesity and its cardiovascular consequences and presents some ways in which it can be managed.10981054
Increased insulin level, Dyslipidemias, Hypertension, CTCAE, AtherosclerosisDeregulated Nutrient SensingRegular physical exercise may prevent or ameliorate conditions associated with hyperinsulinemia including dyslipidemia, hypertension, and atherosclerosis in this group.10983904
No metabolic abnormalities, NEUROD1 wt AlleleDeregulated Nutrient SensingThe persistence of insulin resistance and of high neutral lipid exchanges between triglyceride rich lipoproteins and HDL in insulin-treated NIDDM patients probably explain the inefficiency of insulin therapy to correct HDL apoA-I metabolic abnormalities.10996359
Breast CarcinomaDeregulated Nutrient SensingRelations of insulin resistance and serum concentrations of estradiol and sex hormone-binding globulin to potential breast cancer risk factors.11011124
Increased insulin level, Breast CarcinomaDeregulated Nutrient SensingThere is a hypothesis that hyperinsulinemia or insulin resistance may be a mediator for breast cancer risk factors.11011124
Breast CarcinomaDeregulated Nutrient SensingWe also examined whether insulin resistance would explain the association of breast cancer risk factors with serum estradiol and sex hormone-binding globulin (SHBG).11011124
Breast CarcinomaDeregulated Nutrient SensingThere is a possibility that effect of BMI on breast cancer risk is mediated by both insulin resistance and estrogen metabolism.11011124
Glucose Intolerance (disease)Deregulated Nutrient SensingFurthermore, the proportionally constant participation of PI to insulin secretion observed in various stages of glucose intolerance suggests that the results obtained in the past with non specific insulin radioimmunoassays remain valid.11011219
Uremia, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingBecause of the presence of dyslipidemia and the high incidence of cardiovascular and neoplastic diseases in uremic patients, we evaluated CLA and its metabolites in these patients in order to evaluate their metabolism and site distribution.11012903
HypertriglyceridemiaDeregulated Nutrient SensingThese results suggest that PI could be responsible for the development of hypertriglyceridemia by a mechanism independent of insulin resistance which remains to be elucidated.11014386
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons.11018080
Dyslipidemias, Adjuvant, NEUROD1 wt AlleleDeregulated Nutrient SensingAdjuvant lipostabil is recommended in combined treatment of NIDDM in marked dyslipidemia, alisat--in moderate dyslipidemia.11019431
Nephritis, Tubulointerstitial, Dyslipidemias, Lupus NephritisDeregulated Nutrient SensingThis article focuses on the role of lipids in the progression of glomerular, vascular and tubulo-interstitial lesions in two patients with lupus nephritis associated with pronounced hyper- and dyslipidemia.11020963
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity and hypertension, the major modifiable clinical determinants of left ventricular mass, are both associated with a state of insulin resistance.11021954
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFurther surveillance in this population is essential in verifying the impact of dyslipidemia as a risk of cardiovascular disease in Thai elderly people.11023086
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia were treated with similar goals in each group.11023140
Familial generalized lipodystrophy, Myeloid Leukemia, Chronic, Autosomal recessive inheritanceDeregulated Nutrient SensingCongenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth.11023150
Muscle Fibers, Fast-Twitch, Myeloid Leukemia, ChronicDeregulated Nutrient SensingWe conclude that insulin resistance in patients with CGL is associated with an increased proportion of type II muscle fibers but not reduced capillary density.11023150
OverweightDeregulated Nutrient SensingAlong with genetically low postprandial insulin secretion, they are found to be less tolerable to being overweight to develop insulin resistance.11024579
Weight GainDeregulated Nutrient SensingThe body weight change in the prediabetic era consisting of 508 male patients treated on their diet alone was reviewed and it was found that a few kilograms of weight gain could be a cause of insulin resistance.11024579
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingTo determine whether variation in the IRS-1 gene contributes to genetic susceptibility to insulin resistance and Type 2 diabetes in Mexican Americans, the entire coding region of the IRS-1 gene was screened for variation in 31 unrelated subjects with Type 2 diabetes using single-stranded conformational polymorphism analysis (SSCP) and dideoxy sequence analysis.11025561
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingPrevalence and phenotypic distribution of dyslipidemia in type 1 diabetes mellitus: effect of glycemic control.11025785
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingData on the prevalence of dyslipidemia in type 1 diabetes mellitus are scarce and are based on total triglyceride and total cholesterol concentrations alone.11025785
Dyslipidemias, diabeticDeregulated Nutrient SensingAfter glycemic optimization (mean +/- SD glycosylated hemoglobin decrease, 2.2 +/- 1.96 percentage points), the prevalence of LDL-C levels greater than 4.13 mmol/L (>160 mg/dL) became lower in diabetic men than in nondiabetic men (9.7% vs 17.5%; P =.04), but women showed frequencies of dyslipidemia similar to their nondiabetic counterparts.11025785
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe improvement caused by glycemic optimization puts forward intensive therapy as the initial treatment of choice for dyslipidemia in poorly controlled type 1 diabetes.11025785
Focal glomerulosclerosis, DyslipidemiasDeregulated Nutrient SensingFrom retrospective studies, it has been suggested that aggressive lipid-lowering with low-density lipoprotein apheresis (LDL-A) may not only improve dyslipidemia but also decrease urinary albumin excretion and increase serum levels of albumin in patients with focal segmental sclerosis.11029600
Diabetes MellitusDeregulated Nutrient SensingIRS-2 inactivation in mice induces a form of diabetes characterized by peripheral insulin resistance and reduced beta cell mass.11030756
Failure, Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingConversely, among overweight patients there was a parallel increase in fasting plasma glucose (P for trend = 0.037) and fasting C-peptide according to the dosage of the D1057 allele, suggesting that higher insulin resistance and relative beta cell failure contributed to the increased risk of type 2 diabetes in overweight carriers of this allele.11030756
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe majority (74.1%) had moderate and severe grades of ED on admission to the studies, 31% had hypertension, 16% had documented coronary artery disease, 16% had dyslipidemia and 16% had diabetes.11035390
Increased insulin level, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate the contribution of the liver to whole-body insulin resistance in patients with type 2 diabetes mellitus, we analyzed the early decline (slope "a") in the baseline plasma glucose level following acute hyperinsulinemia in the initial phase of a euglycemic hyperinsulinemic clamp study, rather than using an isotope-dilution method.11036875
diabeticDeregulated Nutrient SensingSlope "a" was comparable among groups of diabetic and non-diabetic subjects, and did not correlate well with glucose infusion rate (GIR), an index of peripheral (primarily skeletal muscle) insulin resistance.11036875
Obesity, diabeticDeregulated Nutrient SensingIn contrast, slope "a" was significantly lower in obese (BMI > 25) type 2 diabetic patients compared with their non-obese counterparts, consistent with the general belief that obesity is a condition of insulin resistance in liver as well as in peripheral tissues.11036875
Hepatobiliary Disorder, Malignant Neoplasms, Glucose Intolerance (disease)Deregulated Nutrient SensingIt is often associated with glucose intolerance, liver disease, and malignant tumors of the lungs.11045160
Increased insulin levelDeregulated Nutrient SensingInsulin resistance and hyperinsulinemia: No independent relation to left ventricular mass in humans.11056098
Increased insulin level, Cardiac HypertrophyDeregulated Nutrient SensingHyperinsulinemia and insulin resistance may contribute to the development of cardiac hypertrophy.11056098
HyperinsulinismDeregulated Nutrient SensingTo clarify the role of insulin resistance and hyperinsulinaemia in the pathogenesis of obesity-related hypertension.11057433
Coronary heart diseaseDeregulated Nutrient SensingThese results demonstrate that variations in concentrations of RLPs are highly correlated with changes in sigmaIRI, consistent with the possibilities that 1) RLP measurements are useful estimates of insulin resistance; and 2) an increase in RLP concentrations may provide the mechanistic link between insulin resistance and coronary heart disease.11061501
Microunit per MilliliterDeregulated Nutrient SensingLipodystrophic children had higher fasting insulinaemia (7.0+/-8.5 versus 3.0+/-2.3 microU/ml; P = 0.07), suggesting a certain degree of insulin-resistance.11061653
Lipodystrophy, DyslipidemiasDeregulated Nutrient SensingInsulin-resistance occurs in lipodystrophic children only, whereas dyslipidaemia exists in non-lipodystrophic children as well, suggesting that dyslipidaemia could reflect subclinical alteration of the adipose tissue.11061653
Lipodystrophy, Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingHypercholesterolaemia (23% versus 15%; P = 0.59 ) and hypertriglyceridaemia (15% versus 11%; P = 0.76) were observed with the same proportion in the lipodystrophic as in the non-lipodystrophic groups; 23% of the non-lipodystrophic children had dyslipidaemia.11061653
Breast Carcinoma, Hirsutism, ItalyDeregulated Nutrient SensingMarkers of insulin resistance and sex steroid hormone activity in relation to breast cancer risk: a prospective analysis of abdominal adiposity, sebum production, and hirsutism (Italy).11065009
Breast CarcinomaDeregulated Nutrient SensingInsulin resistance and increased levels of serum steroids have been hypothesized to be relevant etiological factors for breast cancer.11065009
Breast CarcinomaDeregulated Nutrient SensingMeasurements of markers of insulin resistance and elevated serum steroids may identify women at high risk for breast cancer.11065009
Hirsutism, Breast CarcinomaDeregulated Nutrient SensingThe present study analyzed the association of breast cancer with markers of insulin resistance and elevated serum sex steroids, abdominal adiposity, increase in sebum production and hirsutism in a case-control study nested in a prospective cohort study.11065009
Hypertension, CTCAEDeregulated Nutrient SensingThe results also indicate a central activation of the sympathetic nervous system, such as in the early phases of hypertension, correlating with insulin resistance.11068954
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingInteraction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus.11073182
Dyslipidemias, Cardiovascular Diseases, lipoprotein disorderDeregulated Nutrient SensingA genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism.11073182
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe frequency of the Asn/Ser genotype was significantly increased in normoglycaemic subjects with hypertriglyceridaemia (> 1.7 mmol/1), and was associated with dyslipidaemia and increased systolic blood pressure.11073182
Prostate Cancer Outcomes Study, Endocrine System Diseases, Obesity, Hyperandrogenism, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder characterized by obesity, hyperandrogenism, and insulin resistance.11073846
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingTo investigate the safety and efficacy of niacin in daily doses of 1.5 and 3.0 g in patients with ischemic heart disease and dyslipidemia.11075282
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingNiacin is a safe, effective and a low cost alternative in the treatment of patients with ischemic heart disease and dyslipidemia.11075282
Lipoatrophic Diabetes Mellitus, Insulin resistance syndromeDeregulated Nutrient SensingLipoatrophic diabetes mellitus is a rare insulin-resistance syndrome.11077638
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn middle-aged siblings of patients with type 2 diabetes mellitus normal glucose tolerance is associated with insulin resistance and with increased insulin secretion.11078993
Depression, CTCAEDeregulated Nutrient SensingInsulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis.11079812
Increased insulin level, Glucose Intolerance (disease), Depression, CTCAEDeregulated Nutrient SensingA high proportion of patients with depression develop glucose intolerance accompanied by hyperinsulinemia, suggestive of reduced insulin sensitivity (insulin resistance).11079812
CarcinogenesisDeregulated Nutrient SensingThis observation illustrates the multistep process of carcinogenesis in the non-cirrhotic liver and raises the question of i) the origin of this iron overload possibly linked to insulin resistance syndrome and ii) the role of iron as a co-carcinogen.11084432
Increased insulin level, Muscle (organ)Deregulated Nutrient SensingAccording to our hypothesis, muscle loss allows for the full expression of hyperinsulinemia and insulin resistance, which allows the fuel previously directed to the muscle to be deposited as adipose tissue.11090303
Cardiovascular DiseasesDeregulated Nutrient SensingThe known metabolic cardiovascular disease risk factors associated with insulin resistance syndrome (IRS) do not adequately explain the excess cardiovascular disease risk attributed to this syndrome, and abnormalities in hemostatic variables may contribute to this excess risk.11092431
Tumor necrosisDeregulated Nutrient SensingGiven that the NcoI polymorphism of the tumor necrosis factor-beta (TNF-beta) gene has been shown to be associated with tumor necrosis factor-alpha (TNF-alpha) secretory capacity, we know that this TNF-beta gene polymorphism may influence insulin resistance.11092520
Obesity, Diabetes MellitusDeregulated Nutrient SensingLeptin, an adipose tissue-derived product of the obesity (OB) gene, is an important regulator of energy metabolism and may be associated with the occurrence of insulin resistance and diabetes in humans.11093287
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingInsulin resistance syndrome in childhood, characterized by high blood pressure, dyslipidemia, and hyperinsulinemia, may be an early marker of cardiovascular risk.11093287
Skeletal muscle structureDeregulated Nutrient SensingObese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle.11093291
diabeticDeregulated Nutrient SensingHybrid receptors (HRs), insulin receptor (IR)/insulin-like growth factor I receptor (IGF-I-R) heterodimers have been reported increased in skeletal muscle of obese and type 2 diabetic patients and to contribute to the patient insulin resistance.11095457
ObesityDeregulated Nutrient SensingTo investigate whether or not the increased expression of hybrid receptors is an early defect (probably genetic) of insulin resistance, we measured by specific enzyme-linked immunosorbent assays both IR, IGF-I-R, and HR content in skeletal muscle of healthy nonobese, nondiabetic subjects either insulin sensitive or insulin resistant, and also in patients with moderate obesity.11095457
Thrombosis, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRisk factors like hypertension, diabetes mellitus, dyslipidemia and smoking contribute to the pathogenesis of atherothrombosis.11111140
Skeletal muscle structureDeregulated Nutrient SensingIt is hypothesized that these impairments in fatty acid utilization may play a role in the etiology of skeletal muscle and hepatic insulin resistance.11118013
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingWe estimated risk for type 2 diabetes and milder degrees of glucose intolerance associated with parental diabetes among subjects of the population-based Framingham Offspring Study, in which participants are primarily Caucasian and at relatively low risk for diabetes and for which both parental and offspring phenotypes were ascertained by direct examination.11118026
Glucose Intolerance (disease), Diabetes Mellitus, diabeticDeregulated Nutrient SensingFor maternal diabetes to confer excess risk for mild but not overt glucose intolerance, offspring of diabetic fathers may transit abnormal to impaired glucose tolerance relatively quickly, or diabetic mothers may transmit risk for a mild slowly progressive form of abnormal glucose tolerance in addition to overt diabetes.11118026
Hyperglycemia, HEPATIC LIPASE DEFICIENCY (disorder)Deregulated Nutrient Sensingmin(-1) or 60.4 vs. 51.4% of EGP, P < 0.02), GNG was within normal limits (less than the mean +/- 2 SD of controls or <65.3%) in 11/14 (79%) patients with mild to moderate hyperglycemia (FPG <10 mM) and in 5/13 (38%) of patients with severe hyperglycemia (FPG 10-20 mM); 3) that elevated GNG in T2DM was associated with a 43% decrease in prehepatic insulin secretion, i.e., with hepatic insulin deficiency; and 4) that FPG correlated significantly with glucose clearance (insulin resistance) (r = 0.70) and with GNG (r = 0.50) or EGP (r = 0.45).11120655
Hyperglycemia, HEPATIC LIPASE DEFICIENCY (disorder)Deregulated Nutrient SensingWe conclude 1) that peripheral insulin resistance is at least as important as GNG (and EGP) as a cause of postabsorptive hyperglycemia in T2DM and 2) that GNG and EGP in T2DM are increased under conditions of significant hepatic insulin deficiency and thus probably represent a late event in the course of T2DM.11120655
Hypertension, CTCAEDeregulated Nutrient SensingThese findings offer a potential mechanistic explanation of the links among insulin resistance, impaired insulin-mediated vasodilatation and hypertension.11121808
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingThe displayed lipid profile is also known as the atherogenic profile and is associated with insulin resistance, type 2 diabetes mellitus, and an increased risk of cardiovascular disease.11127274
Triglycerides, diabeticDeregulated Nutrient SensingRemnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.11128349
diabeticDeregulated Nutrient SensingUnivariate regression analysis showed that insulin resistance was positively correlated with BMI (r = 0.254, P = 0.019), HbA1c levels (r = 0.278, P = 0.011), RLP cholesterol levels (r = 0.315, P = 0.004), and triglyceride levels (r = 0.332, P = 0.002) and was negatively correlated with HDL cholesterol levels (r = -0.301, P = 0.006) in our diabetic patients.11128349
diabeticDeregulated Nutrient SensingMultiple regression analysis showed that insulin resistance was independently associated with serum triglyceride levels, which explained 13.5% of the variability of insulin resistance in our nonobese Japanese type 2 diabetic patients.11128349
diabeticDeregulated Nutrient SensingThese results indicate that 1) nonobese Japanese type 2 diabetic patients with insulin resistance are characterized by high RLP cholesterol and triglyceride levels, and low HDL cholesterol levels; and 2) the level of serum triglycerides is an independent predictor of insulin resistance in these patients.11128349
macroangiopathy, Hyperhomocysteinemia, Diabetes Mellitus, Non-Insulin-Dependent, Kidney DiseasesDeregulated Nutrient SensingHyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance.11128359
macroangiopathy, Diabetes Mellitus, Non-Insulin-Dependent, Kidney DiseasesDeregulated Nutrient SensingElevated plasma tHcy levels in type 2 diabetes is associated with a higher prevalence of macroangiopathy and nephropathy when assessed from creatinine clearance indexes and is not associated with different degrees of insulin resistance.11128359
MicroalbuminuriaDeregulated Nutrient SensingRisk variables of insulin resistance syndrome in African-American and Caucasian young adults with microalbuminuria: the Bogalusa Heart Study.11130771
MicroalbuminuriaDeregulated Nutrient SensingThese results suggest that microalbuminuria is not necessarily an intrinsic component of the insulin resistance syndrome, at least in the young adult age.11130771
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of Type 2 diabetes mellitus was very high especially in older subjects, and fibrinogen was associated with increasing glucose intolerance in men but not in women.11131105
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe clustering of hypertension, insulin resistance, and obesity remains unexplained.11136689
Hypertension, CTCAEDeregulated Nutrient SensingClustering of hypertension and insulin resistance in Hispanic Americans is accounted for in part by heritable factors both associated with and independent of BMI.11136689
Peripheral Vascular Diseases, Dyslipidemias, diabeticDeregulated Nutrient SensingThe only significant differences were a higher prevalence of peripheral vascular disease and dyslipidemia in the diabetic group and a higher prevalence of hemispheric transient ischemic attacks among the nondiabetic patients.11137935
Dyslipidemias, Vascular Diseases, Nephrotic Syndrome, Hypertension, CTCAEDeregulated Nutrient SensingMany other factors--linked to the time of TP--may be involved in vascular diseases, such as nephrotic syndrome, dyslipidemia, hypertension and drugs.11140810
Obesity, diabeticDeregulated Nutrient SensingIn conclusion, no major difference was associated with TNF1 and TNF2 polymorphisms in terms of obesity, blood pressure, lipids, or glucose in young, older, or diabetic Japanese men, although FPG was significantly higher in older men, possibly through increased insulin resistance.11145126
Retinal Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingAdditional adjustment for baseline insulin resistance, blood pressure, body mass index, presence of cardiovascular disease and retinopathy, current smoking, or estimates of glomerular filtration rate did not materially affect the results.11145936
Obesity, Diabetes MellitusDeregulated Nutrient SensingMajor determinants of fasting triglycerides, namely, diabetes, obesity, other factors related to insulin resistance, and male sex, were not independently associated with postprandial responses.11156865
ObesityDeregulated Nutrient SensingThe independent atherogenic influence of postprandial lipids may relate more to smoking and diet than to obesity and insulin resistance.11156865
Dyslipidemias, HIV, HMGA2 ProteinDeregulated Nutrient SensingHuman immunodeficiency virus (HIV) lipodystrophy (LIPO) is characterized by increased visceral adiposity, peripheral fat atrophy, dyslipidemia, and insulin resistance.11158000
Kidney Failure, Chronic, Cardiovascular morbidity, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is common in end-stage renal disease (ESRD), and hemodialysis patients have increased cardiovascular morbidity and mortality.11158861
Sepsis, Hypermetabolism, Traumatic injuryDeregulated Nutrient SensingPatients with sepsis and trauma are characterised by hypermetabolism, insulin resistance and protein catabolism.11161543
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt is not related to dyslipidemia or diabetes.11165964
Acanthosis NigricansDeregulated Nutrient SensingFour had acanthosis nigricans which is a cutaneous marker of insulin resistance and the other four had high plasma levels of insulin and/or C peptide.11168330
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingConcordance between fasting and 2-h post-glucose challenge criteria for the diagnosis of diabetes mellitus and glucose intolerance in high risk individuals.11168338
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe new lower fasting criteria might be too insensitive to identify a large proportion of individuals with diabetes or impaired glucose intolerance, particularly in a high-risk population.11168338
HypertriglyceridemiaDeregulated Nutrient SensingMaximal post-prandial triglyceride increase reflects post-prandial hypertriglyceridaemia and is associated with the insulin resistance syndrome.11168339
HypertriglyceridemiaDeregulated Nutrient SensingTo assess the value of maximal post-prandial triglyceride increase after a high fat, low carbohydrate (CHO) test meal, as index of post-prandial hypertriglyceridaemia and its relation with insulin resistance.11168339
Left Ventricular Hypertrophy, Hypertension, CTCAE, ObesityDeregulated Nutrient Sensing-Dyslipidemia and indices of a low dietary intake of linoleic acid and high intake of saturated and monounsaturated fats, as well as hypertension and obesity, at age 50 predicted the prevalence of LVH 20 years later in this prospective longitudinal cohort study, thereby suggesting that lipids may be important in the origin of LVH.11171792
Elevated diastolic blood pressure, ObesityDeregulated Nutrient SensingThese cases and a small LDL peak particle size were characterized by the features of the insulin resistance syndrome, ie, general and central obesity, elevated diastolic blood pressure, low serum concentrations of high-density lipoprotein (HDL) and apolipoprotein A1 (apoA1), increases in serum triglycerides and circulating insulin peptides, and low insulin-mediated glucose uptake.11172485
MicroalbuminuriaDeregulated Nutrient SensingThe underlying linkage might be microalbuminuria and insulin resistance.11189206
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingThe most important risk factor was smoking (60%) followed by dyslipidaemia (47%) and family history of coronary artery disease (20%).11194015
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingHow cost-effective is the treatment of dyslipidemia in patients with diabetes but without cardiovascular disease?11194239
diabeticDeregulated Nutrient SensingGender-related difference in relationship between insulin resistance and serum leptin level in Japanese type 2 diabetic and non-diabetic subjects.11200943
diabeticDeregulated Nutrient SensingTo investigate the possible existence of an independent correlation, we have assessed serum leptin levels and insulin resistance in Japanese diabetic and non-diabetic subjects by means of Homeostatic Model Assessment (HOMA-R).11200943
Antihypertensive AgentsDeregulated Nutrient SensingInsulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake.11204310
Antihypertensive AgentsDeregulated Nutrient SensingThis study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake.11204310
HyperandrogenismDeregulated Nutrient SensingA radical modification in diet designed to reduce insulin resistance and also involving increased phytoestrogen intake decreases the bioavailability of serum sex hormones in hyperandrogenic postmenopausal women.11205485
Obesity, Diabetes MellitusDeregulated Nutrient SensingOur data suggest that, similar to Type II (non-insulin-dependent) diabetes mellitus, the metabolic burden of obesity and insulin resistance could preferentially precipitate postpubertal clinical onset in male subjects with slowly progressive subclinical (immune-mediated) diabetes.11206410
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance (IR) in older individuals is associated with risk factors for coronary artery disease.11213873
Retinal DiseasesDeregulated Nutrient SensingMarkers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes.11213880
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHomeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes.11213893
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHOMA-IR may constitute a useful method not only for diagnosing insulin resistance, but also for follow-up during the treatment of patients with type 2 diabetes.11213893
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingThe combination of atorvastatin with micronised fenofibrate in patients with severe mixed dyslipidemia may have a favourable effect on some major coronary artery disease risk factors.11214768
Hypoglycemia, Autoimmune reactionDeregulated Nutrient SensingInsulin receptor antibodies can induce severe hypoglycemia or insulin resistance in rare autoimmune syndromes.11217151
Impaired cognition, Feeling powerless, Edema, Glucose Intolerance (disease), Behavioral ticDeregulated Nutrient SensingChronic stress also induced glucose intolerance, suppressed male sexual behaviour, induced behavioural depression (Porsolt's swim despair test and learned helplessness test) and cognitive dysfunction (attenuated retention of learning in active and passive avoidance tests), and immunosuppression (leucocyte migration inhibition and sheep RBC challenged increase in paw oedema in sensitized rats).11218827
DyslipidemiasDeregulated Nutrient SensingIn patients with mixed dyslipidemia, fluvastatin ER 80 mg reduced triglycerides by 21.8% (median 28%) and increased HDL-C by 14.5%.11219479
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with type 2 diabetes and hypertension constitute a high risk category with a more atherogenic risk factor profile related to the insulin resistance syndrome.11220508
Hypertensive (finding)Deregulated Nutrient SensingA study of the influence of insulin resistance on left ventricular mass in hypertensive patients.11229109
Hypertensive (finding)Deregulated Nutrient SensingTo study the influence of insulin resistance on the left ventricular mass in hypertensive subjects.11229109
Increased insulin level, Hypertension, CTCAE, Ventricular hypertrophyDeregulated Nutrient SensingThus, in patients with essential hypertension, hyperinsulinemia (insulin resistance) has a role in promoting left ventricular hypertrophy.11229109
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe new thiazolidinedione drugs such as troglitazone which increase insulin sensitivity in patients with glucose intolerance and diabetes, may be very useful in cases where insulin resistance has resulted in diabetes.11229192
Apolipoprotein E, HypertriglyceridemiaDeregulated Nutrient SensingThe present study was undergone to establish whether apolipoprotein C-III (apoC-III) and apolipoprotein E (apoE) associated with apo B (apoC-III LpB and apoE LpB, respectively), considered to be markers of remnant accumulation, play a role in the hypertriglyceridemia associated with insulin resistance and whether they are related to other biological abnormalities frequently observed in this syndrome.11231921
Corneal Endothelial Cell LossDeregulated Nutrient SensingMarkers of the endothelial damage, plasminogen activator inhibitor-1, tissue plasminogen activator, and von Willebrand factor, which are often increased in the case of insulin resistance, were tested for their correlation with the markers of remnant accumulation.11231921
ObesityDeregulated Nutrient SensingIncreased total and intraabdominal fat (IAF) obesity as well as other metabolic conditions associated with the insulin resistance syndrome (IRS) are related to low levels of sex hormone-binding globulin (SHBG) in young and older Caucasian (CAU) and young African-American (AA) women.11231984
Coronary Artery DiseaseDeregulated Nutrient SensingThese data support the physiologic relevance of the GL as a potential risk factor for coronary artery disease in free-living women, particularly those prone to insulin resistance.11237932
ObesityDeregulated Nutrient SensingAlthough obesity is often associated with insulin resistance and a cluster of metabolic disturbances, the existence of a subgroup of healthy but obese individuals has been postulated.11238480
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingUnder these circumstances they develop high rates of obesity, insulin resistance and type 2 diabetes.11238781
Coronary Artery DiseaseDeregulated Nutrient SensingWhite blood cell count and insulin resistance in patients with coronary artery disease.11240402
Glucose Intolerance (disease), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPatients with glucose intolerance, arterial hypertension or obesity were excluded.11240402
Hypertensive (finding), Hypertension, CTCAE, Endothelial dysfunctionDeregulated Nutrient SensingInsulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension.11240849
Endothelial dysfunctionDeregulated Nutrient SensingEndothelial dysfunction is related to hyperinsulinaemia/insulin resistance, which could be one of the pathogenetic determinants of EH and its complications.11240849
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum insulin, proinsulin and proinsulin/insulin ratio in type 2 diabetic patients: as an index of beta-cell function or insulin resistance.11242807
No metabolic abnormalitiesDeregulated Nutrient SensingAlthough insulin resistance and decreased insulin secretion are characteristics of established type 2 DM, which of these metabolic abnormalities is the primary determinant of type 2 DM is controversial.11242807
Impaired T cell functionDeregulated Nutrient SensingIt is also not well known how insulin resistance and beta cell dysfunction influence serum insulin, proinsulin, proinsulin/insulin ratio in type 2 DM.11242807
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPhysical activity may have both a preventive effect and a secondary preventive effect of lessening insulin resistance in persons with type 2 diabetes.11249259
Hypercholesterolemia, Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingFibrinolytic parameters and insulin resistance in young survivors of myocardial infarction with heterozygous familial hypercholesterolemia.11253736
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingPatients with previous myocardial infarction had significantly higher levels of insulin, insulin resistance, triglycerides, t-PA antigen, PAI-1 antigen and activity, and significantly lower values of HDL cholesterol.11253736
Premature coronary artery atherosclerosis, DyslipidemiasDeregulated Nutrient SensingThe kindred was ascertained for premature coronary heart disease and was expanded based on familial dyslipidemia.11260209
Weight GainDeregulated Nutrient SensingThe insulin resistance caused by olanzapine is normally attributed to the weight gain associated with the drug.11261526
Dyslipidemias, Liver Dysfunction, Diabetes MellitusDeregulated Nutrient SensingBiochemistry and oral glucose tolerance tests showed diabetes mellitus, dyslipidemia, and hepatic dysfunction in the index case.11265260
Increased insulin level, HyperglycemiaDeregulated Nutrient SensingAt present, the patient presents severe hyperglycemia and hyperinsulinemia with a marked insulin resistance.11265632
Low-Density Lipoproteins, Coronary Artery DiseaseDeregulated Nutrient SensingVisceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men.11266194
Glucose Intolerance (disease), Coronary Artery Disease, HyperlipoproteinemiasDeregulated Nutrient SensingVisceral fat accumulation plays an important role in the occurrence of coronary artery disease (CAD) associated with a cluster of multiple risk factors, such as glucose intolerance, insulin resistance and hyperlipoproteinemia.11266194
Nonalcoholic Steatohepatitis, Mitochondrial abnormalitiesDeregulated Nutrient SensingNonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities.11266382
Fatty Liver DiseaseDeregulated Nutrient SensingWe tested the hypothesis that NASH is associated with 2 defects: (1) peripheral insulin resistance, which increases lipolysis, delivery of free fatty acids (FFA) to the liver, and hepatic fatty acid beta oxidation, thereby creating oxidative stress; and (2) an abnormality within the hepatocytes that might render them more susceptible to injury from oxidative stress.11266382
Fatty Liver, Fatty Liver DiseaseDeregulated Nutrient SensingNASH and fatty liver were both associated with insulin resistance, with mean glucose infusion rates (normal/fatty liver/NASH) of step 1, 4.5/1.6/0.9; step 2, 9.5/7.7/4.5 (P < 0.03 for both steps).11266382
Fatty Liver DiseaseDeregulated Nutrient SensingThese data indicate that peripheral insulin resistance, increased fatty acid beta oxidation, and hepatic oxidative stress are present in both fatty liver and NASH, but NASH alone is associated with mitochondrial structural defects.11266382
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results suggest that insulin resistance per se is a significant risk factor for CAD in Japanese patients with type 2 diabetes.11269890
Diabetes Mellitus, Cerebrovascular accidentDeregulated Nutrient SensingIs insulin resistance or diabetes mellitus associated with stroke?11269894
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and/or diabetes are risk factors for coronary artery disease.11269894
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingThe prescription of statins in patients with coronary artery disease and dyslipidemia is high; however, its adherence is far from satisfactory, due to the high cost of the medication.11270314
Diabetes MellitusDeregulated Nutrient SensingIn this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population.11270682
Dyslipidemias, Depression, CTCAEDeregulated Nutrient SensingDespite increasing evidence of an association between lower cholesterol levels and negative mood, no study has specifically investigated this relationship in obese people, a population at high risk for both dyslipidaemia and depression.11274685
Dyslipidemias, ObesityDeregulated Nutrient SensingIn this program, we evaluated the effects of a combination of exercise training and a diet on cardiovascular risk factors such as obesity, dyslipidemia, and poor exercise performance in obese subjects.11279836
Weight decreased, DyslipidemiasDeregulated Nutrient SensingA combination of aerobic exercise and a mild hypocaloric diet significantly contributed not only to weight loss but also to the improvement of dyslipidemia and exercise performance, but either hypocaloric diet or mild exercise independently did less.11279836
Hyperglycemia, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe purpose of the present article is to report on the influence of hyperglycemia on the left ventricular diastolic dysfunction independently of dyslipidemia, obesity, and systemic arterial hypertension, usually present in diabetic patients.11282180
Diastolic dysfunction, Hyperglycemia, Dyslipidemias, ObesityDeregulated Nutrient SensingIndependently of dyslipidemia and obesity, a relationship was found between hyperglycemia and diastolic dysfunction of the left ventricle in patients belonging to group A (p <0.05, odds ratio [OR] 12.1).11282180
GoutDeregulated Nutrient SensingIncreased visceral fat accumulation further aggravates the risks of insulin resistance in gout.11288032
GoutDeregulated Nutrient SensingGout patients possess some factors that are included in the insulin resistance syndrome, irrespective of the presence of VFO, and the insulin resistance risk factors observed in gout become more prominent when it is complicated with VFO.11288032
DyslipidemiasDeregulated Nutrient SensingMonotherapy with sulfonylurea may result in the exhaustion of pancreatic beta-cell function, fat accumulation, and dyslipidemia.11288035
ObesityDeregulated Nutrient SensingThe beta(3)-adrenergic receptor (AR) gene variant (Trp64Arg) has been reported to be associated with obesity and insulin resistance in humans.11288039
diabeticDeregulated Nutrient SensingFrom these results, it can be concluded that bezafibrate reduces serum triglycerides, insulin resistance, and fasting blood glucose levels in non-obese Japanese type 2 diabetic patients.11288046
Chronic Kidney DiseasesDeregulated Nutrient SensingThe insulin resistance state is common in humans and animals with chronic renal failure.11288821
Dyslipidemias, Coronary Artery Disease, Coronary Artery VasospasmDeregulated Nutrient SensingDyslipidemia in patients with coronary vasospasm has been characterized by a low level of high-density lipoprotein (HDL) cholesterol without elevation of low-density lipoprotein (LDL) cholesterol, distinct from patients with organic coronary artery disease.11288968
Dyslipidemias, Coronary Artery VasospasmDeregulated Nutrient SensingThe midband lipoprotein was frequently detected in patients with coronary vasospasm, suggesting that dyslipidemia with disordered triglyceride-rich lipoprotein metabolism may be linked to the genesis of coronary artery spasm.11288968
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings support a role for the PPAR-gamma2 Pro12Ala variant in the etiology of type 2 diabetes and the insulin resistance syndrome.11289057
Cessation of life, Glucose Intolerance (disease)Deregulated Nutrient SensingSubclinical states of glucose intolerance and risk of death in the U.S.11289466
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough clinically evident type 2 diabetes is a well-established cause of mortality, less is known about subclinical states of glucose intolerance.11289466
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe results show that 74.1% of patients had moderate or severe grades of ED on inclusion into the studies, 31% had hypertension, 16% had documented coronary artery disease, 16% had dyslipidemia, and 16% had diabetes.11289567
Diabetes MellitusDeregulated Nutrient SensingFurther, an increase of insulin resistance and development of non-insulin-dependent diabetes mellitus has been described after treatment with IFN-alpha.11293453
TG gene, DyslipidemiasDeregulated Nutrient SensingMaximum mean increases in HDL-C level (21%) and median decreases in TG level (31%) with fluvastatin XL 80 mg HS occurred in patients with type IIb dyslipidemia and the highest baseline TG.11293552
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia in type 2 diabetes has been shown to be related to the incidence of macrovascular events.11293949
Angina PectorisDeregulated Nutrient SensingThe + allele, by influencing iNOS expression, could thus contribute to indices of insulin resistance and angina severity in male CAD patients.11294696
Obesity, Muscle (organ)Deregulated Nutrient SensingThese results suggest that RT may be useful in ameliorating insulin resistance that often occurs with physical inactivity, obesity, and loss of muscular strength in older insulin resistant men and women.11300234
Colorectal CarcinomaDeregulated Nutrient SensingHigh intake of refined carbohydrates and markers of insulin resistance are associated with colorectal cancer.11300319
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingPossession of the coagulation factor XIII Val34Leu (FXIIIVal34Leu) polymorphism is associated with protection against myocardial infarction (MI) in Caucasians, in the absence of features of insulin resistance.11307805
Coronary ArteriosclerosisDeregulated Nutrient SensingThe role of this polymorphism in the UK Asian population, with its high prevalence of insulin resistance and ischaemic heart disease, is unknown.11307805
Cardiovascular DiseasesDeregulated Nutrient SensingFXIII B-subunit levels are strongly linked to risk factors for cardiovascular disease, suggesting an underlying association with insulin resistance.11307805
Tumor necrosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus.11311966
Tumor necrosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe analyzed serum concentrations of tumor necrosis factor-alpha (TNF-alpha) for their role in insulin resistance in 12 obese men with untreated Type 2 diabetes mellitus and in 6 age-and BMI-matched obese controls.11311966
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese data suggest that high levels of serum TNF-alpha in patients with insulin resistance are related to high levels of fasting insulin and HOMA-R. We conclude that TNF-alpha may be involved in the pathogenesis of Type 2 diabetes mellitus in obese men.11311966
Microalbuminuria, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMicroalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population.11311969
Increased insulin level, Microalbuminuria, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThese results show that microalbuminuria in the Korean general population is associated with hyperinsulinemia and central obesity, and suggest that microalbuminuria is a feature of the insulin resistance syndrome independent of hypertension or type 2 diabetes.11311969
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingPrevalence and determinants of diabetes mellitus and glucose intolerance in a Canarian Caucasian population - comparison of the 1997 ADA and the 1985 WHO criteria.11318846
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes mellitus and glucose intolerance in Guia is one of the highest among studied Caucasian populations.11318846
Dyslipidemias, AtherosclerosisDeregulated Nutrient Sensing[J-curve between alcohol consumption and carotid atherosclerosis in patients with dyslipidemia].11322030
Thrombus, Hypertensive (finding)Deregulated Nutrient SensingThese parameters described a prothrombotic state associated with an insulin resistance state, an increased vWF release, raised sP-Sel and TNFalpha levels and, maybe, low NO bioavailability, which could lead to a higher risk of development of thrombotic events in hypertensive diabetic patients (Group A) than in the hypertensive patients in Group B.11323020
Hyperglycemia, Hypertension, CTCAEDeregulated Nutrient SensingHyperglycemia related to insulin resistance in hypertension in Tanzania is associated with increased urinary 8-OHdG.11327625
Apolipoproteins B, Glucose Intolerance (disease), Coronary ArteriosclerosisDeregulated Nutrient SensingGlucose intolerance was present in about one-half the recipients and was associated with age, a positive family history of ischaemic heart disease, acute rejection, higher levels of serum triglycerides, apolipoprotein B and 2-h insulin, and lower levels of serum HDL cholesterol.11328915
Apolipoproteins B, Glucose Intolerance (disease)Deregulated Nutrient SensingAfter adjustment for age and sex, lower HDL cholesterol (P=0.005), higher serum triglycerides (P<0.001), apolipoprotein B (P=0.039) and 2-h insulin (P<0.001) were still associated with post-transplant glucose intolerance.11328915
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTraditional risk factors like hypertension, dyslipidaemia and diabetes mellitus are common, but cannot completely account for the high prevalence of CVD in this population.11328915
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe treatment of obesity and insulin resistance in adults often proves ineffective because the vicious cycle leading to type 2 diabetes may have become entrenched and, to some extent, may be irreversible.11335776
Weight Gain, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEarly detection and therapy of the obese adolescent with a family history of type 2 diabetes may interrupt the cycle of weight gain and insulin resistance that leads to glucose intolerance in adulthood.11335776
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingWe reasoned that drugs that increase glucose tolerance in diabetic patients might prove useful in preventing the progression to glucose intolerance in high-risk patients.11335776
Hypertension, CTCAE, Overweight, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHypertension, dyslipidemia and overweight contribute substantially to cardiovascular disease risk.11340101
Cerebrovascular DisordersDeregulated Nutrient SensingInsulin resistance and elevated levels of tissue plasminogen activator in first-degree relatives of South Asian patients with ischemic cerebrovascular disease.11340211
Increased insulin level, Cerebrovascular accidentDeregulated Nutrient SensingSouth Asians stroke relatives exhibit hyperinsulinemia, increased insulin resistance, and increased tissue plasminogen activator levels.11340211
Atherosclerosis, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe common insulin resistance syndrome, with obesity, dyslipidemia, hyperglycemia, and hypertension, is associated with increased risk of atherosclerosis.11342468
AtherosclerosisDeregulated Nutrient SensingEarly atherosclerosis in rare monogenic forms of insulin resistance, however, has not been extensively documented.11342468
LMNA wt AlleleDeregulated Nutrient SensingAll LMNA mutation carriers had FPLD with insulin resistance.11342468
LMNA wt Allele, Increased insulin level, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingRare LMNA mutations that underlie FPLD with insulin resistance and hyperinsulinemia are also associated with early CHD, notably in women.11342468
Cardiovascular DiseasesDeregulated Nutrient SensingThis suggests that abnormalities of the nuclear envelope can result in a phenotype that recapitulates most of the important attributes of the common insulin resistance syndrome, including accelerated cardiovascular disease.11342468
LMNA wt AlleleDeregulated Nutrient SensingFPLD thus appears to be an appropriate human monogenic model for the common insulin resistance syndrome.11342468
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingIn addition, LMNA mutation carriers had significantly more type 2 diabetes, hypertension, and dyslipidemia than normal family control subjects.11342468
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to ascertain whether the presence of hypertension conveys a more severe degree of insulin resistance in type 2 diabetes mellitus and, if so, which biochemical pathways are involved.11344209
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThese results indicate that hypertension markedly aggravates insulin resistance featuring type 2 diabetes mellitus.11344209
Glucose Intolerance (disease), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingGlucocorticoid excess frequently results in obesity, insulin resistance, glucose intolerance, and hypertension and may be the product of altered glucocorticoid hormone action.11344242
Hypertensive (finding), diabeticDeregulated Nutrient SensingThis applies not only to postmenopausal women, elderly people, obese and diabetic subjects, hypertensive subjects with insulin resistance but also to young subjects.11344644
Weight GainDeregulated Nutrient SensingAlthough the mechanism is not yet known, it has been hypothesized that perhaps damage to the pancreatic islet cells, weight gain, dysregulation of the sympathetic system, and insulin resistance are contributing factors.11346063
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Prevalence of type 2 diabetes mellitus and glucose intolerance in the Setif area (Algeria)].11353884
DyslipidemiasDeregulated Nutrient SensingWomen who developed IFG during the menopausal transition exhibited significantly higher levels of body fatness and dyslipidemia, premenopausally, compared with the women who did not develop IFG.11360146
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe occurrence of obesity and dyslipidemia was relatively high in the Aymara population, although the frequency of sedentary habits, and the prevalence of hypertension were low.11369169
Hypertension, CTCAEDeregulated Nutrient SensingSetback in insulin resistance has been described in patients with essential hypertension.11374224
DyslipidemiasDeregulated Nutrient SensingHigh-flux hemodialysis has been reported to attenuate renal dyslipidemia.11374763
Calcification of coronary artery, Cardiovascular DiseasesDeregulated Nutrient SensingReduced heart-rate variability clusters with other cardiovascular disease risk factors, especially those that are more common in the insulin resistance syndrome, and is associated with increased coronary calcification in asymptomatic young adults.11375379
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingEfficacy of atorvastatin in achieving National Cholesterol Education Program low-density lipoprotein targets in women with severe dyslipidemia and cardiovascular disease or risk factors for cardiovascular disease: The Women's Atorvastatin Trial on Cholesterol (WATCH).11376309
Dyslipidemias, ObesityDeregulated Nutrient SensingWe have determined the efficacy and frequency of achieving target levels for LDL-C with atorvastatin on the basis of National Cholesterol Education Program Adult Treatment Panel II recommendations in 318 women according to the presence of CVD (198 women) or risk factors for CVD (120 women) and the presence of mixed dyslipidemia with obesity with or without CVD (72 women).11376309
Dyslipidemias, ObesityDeregulated Nutrient SensingThe presence of mixed dyslipidemia with obesity did not affect the frequency of achieving LDL-C targets.11376309
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThe concordance rates for glucose intolerance, overall obesity and low HDL-cholesterol were significantly higher among monozygotic than dizygotic twins indicating a genetic influence on the development of these phenotypes.11380071
NeoplasmsDeregulated Nutrient SensingLoss of body weight after removal of the tumor correlated with a dramatic reduction of insulin resistance to such a degree that diet alone proved sufficient for satisfactory glycemic control.11388080
ObesityDeregulated Nutrient SensingEndothelin-1 levels are not related to blood pressure, but are higher in healthy young men with insulin resistance and obesity.11391030
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingA number of risk factors have been identified in young and middle-aged adults, such as dyslipidemia, hypertension and diabetes.11393007
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingIn conclusion, dyslipidaemia in patients with HIV infection was significantly associated with adherence to PI-containing antiretroviral therapy.11394983
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSo far, it is not clear if increased cholesterogenesis in type 2 diabetes is related to the degree of glycemic control or depends on the commonly associated dyslipidemia or both.11395032
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Smoking, AtherosclerosisDeregulated Nutrient SensingSmoking is associated with increased hepatic lipase activity, insulin resistance, dyslipidaemia and early atherosclerosis in Type 2 diabetes.11395034
Dyslipidemias, Atherosclerosis, diabeticDeregulated Nutrient SensingWe have studied the relationships between hepatic lipase activity, smoking, dyslipidaemia insulin resistance, and early atherosclerosis in 67 Type 2 diabetic subjects, 47 non-smokers and 20 smokers.11395034
Dyslipidemias, diabeticDeregulated Nutrient SensingWe suggest that smoking accentuates the dyslipidaemia of Type 2 diabetic subjects and this is associated with increased hepatic lipase activity.11395034
Cardiovascular DiseasesDeregulated Nutrient SensingThe potential role of haemostatic risk markers is largely unexplored in South Asians, who have increased morbidity and mortality from cardiovascular disease and an increased prevalence of insulin resistance.11395044
DyslipidemiasDeregulated Nutrient SensingThese results suggest that elevated PAI-1 and fibrinogen in Asians of both genders may contribute to the increased vascular risk experienced in this population; however, the role of dyslipidaemia and Factor VII are not clear in these processes.11395044
Dyslipidemias, ObesityDeregulated Nutrient SensingThese results suggest that obesity and abdominal AT accumulation are the critical correlates of elevated plasma CRP levels found in men with atherogenic dyslipidemia of the insulin resistance syndrome.11397704
Weight Gain, Obesity, VisceralDeregulated Nutrient SensingIncreasing leptin fails to prevent weight gain and the hypogonadal-obesity cycle ensues causing further visceral obesity and insulin resistance.11399122
DyslipidemiasDeregulated Nutrient SensingThe progressive insulin resistance leads to a high triglyceride-low HDL pattern of dyslipidemia and increased cardiovascular risk.11399122
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingSubjects with IFG had a non-trivial undiagnosed diabetes mellitus rate (30% in men and 42% in women) and a high rate of glucose intolerance and undiagnosed DM combined (75% in men and 86% in women).11403519
IFNG wt Allele, Glucose Intolerance (disease), Demographics DomainDeregulated Nutrient SensingWomen with IFG had a 1.6 fold higher risk (p = 0.04) for undiagnosed DM and a 2.1 fold higher risk (p = 0.01) for glucose intolerance and DM when compared to men.11403519
AlbuminuriaDeregulated Nutrient SensingInsulin resistance precedes the appearance of albuminuria in non-diabetic subjects: 6 years follow up study.11403858
Hypertension, CTCAE, AlbuminuriaDeregulated Nutrient SensingInsulin resistance appeared earlier than the appearance of hypertension and albuminuria.11403858
AlbuminuriaDeregulated Nutrient SensingTherefore, the appearance of insulin resistance should be regarded as a remarkable mediator of albuminuria.11403858
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology, Tumor necrosisDeregulated Nutrient SensingTemporary reversal by topotecan of marked insulin resistance in a patient with myelodysplastic syndrome: case report and possible mechanism for tumor necrosis factor alpha (TNF-alpha)-induced insulin resistance.11404500
Tumor necrosis, Obesity, Diabetes MellitusDeregulated Nutrient SensingTumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor.11404500
Myelodysplasia, Respiratory Distress Syndrome, NewbornDeregulated Nutrient SensingWe report here a remarkable degree of insulin resistance in a patient with adult respiratory distress syndrome and myelodysplasia.11404500
Dyslipidemias, Biliary calculi, Diabetes MellitusDeregulated Nutrient SensingDiabetes, gallstones and dyslipidaemia are widespread, metabolically related, disorders that can affect the liver, often in a clinically silent fashion.11407669
NEUROD1 wt AlleleDeregulated Nutrient SensingIn conclusion, troglitazone can restore coronary circulation by improving insulin resistance in patients with NIDDM.11407727
Fetal Growth RetardationDeregulated Nutrient SensingInsulin resistance and insulin-like growth factors in children with intrauterine growth retardation.11408754
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAs expected, body weight and fat distribution were associated with diabetes, hypertension, dyslipidemia and with a worsening of lipid profile.11410818
Blood GlucoseDeregulated Nutrient SensingA moderately high but still normal glycemia might be a preclinical sign of insulin resistance or other disturbance of glucoregulation.11415852
Weight decreased, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance precedes weight loss in adults without diabetes : the Rancho Bernardo Study.11415955
Weight decreased, OverweightDeregulated Nutrient SensingInsulin resistance is closely associated with both aging and overweight; yet in old age, weight loss is common, although insulin resistance increases.11415955
Adrenal incidentalomaDeregulated Nutrient SensingThe improvement of insulin resistance in patients with adrenal incidentaloma by surgical resection.11422115
Adrenal Cortical AdenomaDeregulated Nutrient SensingAll 12 patients with adrenocortical adenoma exhibited insulin resistance based on the SSPG (6.9-13.2 mmol/l).11422115
Cushing Syndrome, Adrenal Cortical Adenoma, NeoplasmsDeregulated Nutrient SensingBefore surgical removal of the tumours, the SSPG titre was relatively higher in the patients with pre-clinical Cushing's syndrome than in those with non-functioning with adrenocortical adenoma (mean value 11.65 vs. 8.99 mmol/l), whereas 2 of the 3 patients with non-adrenocortical tumours did not have insulin resistance.11422115
Hypertension, CTCAE, Non-Functioning Adrenal Cortex AdenomaDeregulated Nutrient SensingHigh prevalences of disturbed glucose tolerance, insulin resistance and hypertension were found among the patients with non-functioning adrenocortical tumours.11422115
Hypertension, CTCAE, Adrenal Cortical AdenomaDeregulated Nutrient SensingAdrenocortical adenoma may be one of the risk factors for insulin resistance that is believed to induce disturbed glucose tolerance and/or hypertension.11422115
square decimeterDeregulated Nutrient SensingThis insulin resistance was further aggravated by the nicotine infusion in DM2 but not in Ctr (4.6 +/- 0.3 vs. 10.9 +/- 0.3 mg kg(-1) LBM min(-1); P < 0.0001).11422660
square decimeterDeregulated Nutrient SensingAt this low infusion rate, nicotine aggravated the insulin resistance in DM2 but not in Ctr.11422660
Exceptionally large baby (disorder), Glucose Intolerance (disease)Deregulated Nutrient SensingAmniotic fluid insulin at 14-20 weeks' gestation: association with later maternal glucose intolerance and birth macrosomia.11423512
Premature coronary artery atherosclerosisDeregulated Nutrient SensingAssociation of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease.11427204
Acanthosis NigricansDeregulated Nutrient Sensing[Successful symptomatic tazarotene treatment of juvenile acanthosis nigricans of the familial obesity-associated type in insulin resistance].11428078
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is an important factor in causation of macrovascular disease in type 2 diabetics.11428472
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe role of simvastatin in the management of dyslipidemia in patients with type 2 diabetes mellitus is not very well elucidated, particularly in the context of the recent American Diabetes Association criteria 2001.11428472
Dyslipidemias, Diabetes Mellitus, Coronary heart diseaseDeregulated Nutrient SensingThe American Diabetes Association suggests that aggressive therapy of diabetic dyslipidemia will reduce the risk of coronary heart disease in diabetics and that optimal levels are serum low-density lipoprotein cholesterol <2.60 mmol/L (< 100 mg/dl), high-density lipoprotein cholesterol >1.1 5 mmol/L (>45 mg/dl) and triglycerides <2.30 mmol/L, (<200 mg/dl).11428472
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThis study was planned to compare the effect of simvastatin together with behavioral modification and behavioral modification alone, in age, sex and body mass index matched patients with type 2 diabetes mellitus with dyslipidemia, in reaching the target levels of various lipids as suggested by the American Diabetes Association criteria 2001.11428472
Low-Density LipoproteinsDeregulated Nutrient SensingIt was observed that low-density lipoprotein dyslipidemia was most prevalent.11428472
DyslipidemiasDeregulated Nutrient SensingIn our study, behavioral modification alone did not achieve the target levels of various lipids in diabetic dyslipidemia as per the American Diabetes Association guidelines.11428472
Calcification of coronary artery, DyslipidemiasDeregulated Nutrient SensingSignificant association between the progression of coronary artery calcification and dyslipidemia in patients on chronic hemodialysis.11431183
Polycystic Ovary SyndromeDeregulated Nutrient Sensing[Effects of metformin on insulin resistance and on ovarian steroidogenesis in women with polycystic ovary syndrome].11431640
Weight decreased, Blood PressureDeregulated Nutrient SensingProbably, weight loss improves insulin resistance and decrease in the plasma insulin level causes a reduction in blood pressure and urinary albumin excretion rate.11431901
Heart Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe part of the cardiovascular risk factors was about 36% for smoking, 13% for diabetes mellitus, 60% for dyslipidemia and 40% for heart disease.11435677
Obesity, Coronary heart diseaseDeregulated Nutrient SensingC-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites.11447077
Choline Dehydrogenase, Mitochondrial, metabolic disturbance, ObesityDeregulated Nutrient SensingCRP values were strongly associated with conventional CHD risk factors, measures of obesity, and metabolic disturbances associated with insulin resistance in both racial groups.11447077
Inflammation, ObesityDeregulated Nutrient SensingCRP was associated with many other cardiovascular risk factors, particularly markers of obesity and insulin resistance, markers of inflammation and acute phase reaction, and hormone replacement therapy.11448405
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe risk of post-transplant diabetes increased parallel to pre-transplant degree of glucose intolerance, but was considerable even in normal glucose tolerance.11448794
Fetal malnutrition without mention of light-for-datesDeregulated Nutrient Sensing"The fetal programming hypothesis" suggests that the association is caused by intrauterine malnutrition while a new hypothesis "the fetal insulin hypothesis" proposes that genetically determined insulin resistance also contributes significantly to the association.11449017
Atherosclerosis, Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance is associated with accelerated atherosclerosis, especially coronary heart disease.11453033
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Corneal Endothelial Cell LossDeregulated Nutrient SensingThese results indicate that endothelial dysfunction may be associated with the pathogenesis of insulin resistance syndrome as well as insulin resistance, and that the plasma TM might reflect endothelial damage better than the plasma vWF in the state of insulin resistance in patients with type 2 diabetes.11453033
Tumor necrosisDeregulated Nutrient SensingTumor necrosis factor-alpha (TNF-alpha) may play an important role in insulin resistance.11453240
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this study, we hypothesized that TNF-alpha produced due to periodontal inflammation synergistically affects insulin resistance as well as TNF-alpha produced from adipose tissues in insulin-resistant type 2 diabetes patients.11453240
AtherosclerosisDeregulated Nutrient SensingRecent evidence suggests that increased activity of plasma plasminogen activator inhibitor-1, an important component of the insulin resistance syndrome, plays a crucial role in the pathogenesis of atherosclerosis.11456143
Damage, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAll in all, the therapeutic strategy will be increasingly be oriented to such additional risk factors as diabetes mellitus, dyslipidemia or already present organic damage.11460393
Hypertension, CTCAEDeregulated Nutrient SensingIncreased insulin resistance in salt sensitive essential hypertension.11464258
Hypertensive (finding)Deregulated Nutrient SensingSalt sensitive essential hypertensive patients are more insulin resistant than salt resistant patients when both salt sensitivity and insulin resistance are accurately measured.11464258
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingIndirect measures of both insulin and salt sensitivity and/or the presence of modifying factors, such as obesity or glucose intolerance, may account for differences in previous studies.11464258
Hypertensive (finding), diabeticDeregulated Nutrient SensingThus, an abundant sodium intake may improve glucose tolerance and insulin resistance, especially in diabetic, salt-sensitive, and or medicated essential hypertensive subjects.11465650
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn addition to severe hypertension, 64 per cent of the patients had other significant high-risk factors for cardiovascular disease: 44 per cent had dyslipidemia, 28 per cent had diabetes mellitus, 15 per cent were smokers.11471361
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance as a major determinant of increased coronary heart disease risk in postmenopausal women with Type 2 diabetes mellitus.11472467
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIncreased insulin resistance in association with elevated PAI-1 and dyslipidaemia appears to underpin the increased risk of CHD in women with Type 2 DM.11472467
DyslipidemiasDeregulated Nutrient SensingProbands and first degree relatives showed dyslipidemia, increased plasma insulin and glucose concentrations, higher waist--hip ratio (WHR), and blood pressure, than spouses.11472750
Increased insulin level, Metabolic Syndrome XDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are considered key components in the metabolic cardiovascular syndrome and as independent risk factors for CVD.11472752
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome XDeregulated Nutrient SensingNAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance.11473047
No metabolic abnormalities, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance, associated metabolic abnormalities, and elevated homocysteine levels are risk factors for cardiovascular disease (CVD).11473077
Increased insulin level, HyperhomocysteinemiaDeregulated Nutrient SensingHyperhomocysteinemia and abnormal urinary albumin excretion are both associated with hyperinsulinemia and may partially account for increased risk of CVD associated with insulin resistance.11473077
Diffuse Axonal Injury, Glucose Intolerance (disease), Peripheral Neuropathy, Diabetes MellitusDeregulated Nutrient SensingOf patients with diabetes, 10% have peripheral neuropathy at the time of their diagnosis, suggesting that axonal injury may occur early in the course of glucose intolerance.11473085
Uremia, HypertriglyceridemiaDeregulated Nutrient SensingAssociation of hypertriglyceridemia and insulin resistance in uremic patients undergoing CAPD.11475344
Uremia, Increased insulin level, HyperlipidemiaDeregulated Nutrient SensingInsulin resistance (or its compensatory hyperinsulinemia) is commonly observed in uremic patients, but its association with hyperlipidemia in these patients has not been studied.11475344
HypertriglyceridemiaDeregulated Nutrient SensingThese results indicate that insulin resistance is an important factor in the development of hypertriglyceridemia in CAPD patients.11475344
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingIn conclusion, the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high and it is among the highest previously reported worldwide.11483632
Diabetes MellitusDeregulated Nutrient SensingThe mechanism by which protease inhibitors cause diabetes is unclear; however, studies have noted insulin resistance and increased proinsulin.11485138
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPeripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes.11485987
DyslipidemiasDeregulated Nutrient SensingWe suggest that terazosin may be a reasonable choice because of the beneficial effect on the lipid profile in older symptomatic BPH patients with a higher ratio of dyslipidemia.11490211
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone improved insulin resistance and glycemic control, as well as Tg and HDL-C - which suggests that pioglitazone may reduce cardiovascular risk for patients with type 2 diabetes.11491207
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus.11491207
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe prevalence of hypertension increased with age whereas smoking and dyslipidaemia decreased in both men and women.11494627
Coronary heart diseaseDeregulated Nutrient SensingCardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease.11498464
Increased insulin level, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingWe conclude that cardiovascular risk factors associated with the insulin resistance syndrome (hyperinsulinemia, low high density lipoprotein cholesterol, high total and very low density lipoprotein triglycerides, and high fibrinogen) are likely to contribute indirectly to early-onset CHD.11498464
Dyslipidemias, Obesity, VisceralDeregulated Nutrient SensingPostprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression?11500319
DyslipidemiasDeregulated Nutrient SensingA delay in the conversion of chylomicrons to remnants probably contributed to postprandial dyslipidemia in viscerally obese subjects.11500319
Dyslipidemias, HypopituitarismDeregulated Nutrient SensingThe dyslipidemia associated with hypopituitarism may contribute to increased vascular mortality.11502830
DyslipidemiasDeregulated Nutrient SensingIn men there was a significant decrease of non-HDL cholesterol, in women, there was a significant increase of subjects with diabetic dyslipidaemia.11505716
Pancreatic carcinoma, ObesityDeregulated Nutrient SensingBy virtue of their influence on insulin resistance, obesity and physical inactivity may increase risk of pancreatic cancer.11509056
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingType 1 diabetes is associated with a high risk of coronary heart disease (CHD), despite the absence of dyslipidemia.11522707
Turner SyndromeDeregulated Nutrient SensingMuscle fiber composition and capillary density in Turner syndrome: evidence of increased muscle fiber size related to insulin resistance.11522717
Turner Syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo assess muscle fiber composition and capillary density in Turner syndrome, a condition linked with insulin resistance and increased frequency of type 2 diabetes, and link these findings with insulin sensitivity and physical fitness.11522717
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance may play an important role in the development of hypertension in young males.11524829
Dyslipidemias, ObesityDeregulated Nutrient SensingThe main dyslipidemia associated with obesity is elevated serum triglyceride and decreased serum high-density lipoprotein cholesterol (HDL-C) levels.11526363
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe DM group had significantly more female patients (45.4 vs 21.1%, p < 0.0001), older age (62.5 +/- 8.2 vs 60.5 +/- 10.8 y, p < 0.007), less smoking (21.8 vs 43.2%, p < 0.0001), more dyslipidemia (56.8 vs 41.9%, p < 0.0001) and a higher incidence of hypertension (51.8 vs 42.5%, p = 0.01).11529371
ObesityDeregulated Nutrient SensingIn females, the index of obesity, insulin resistance, or lipid metabolism did not differ significantly between the subjects with or without the beta(3)-AR gene variant either in the obese and non-obese group.11532330
Obesity, Visceral, ObesityDeregulated Nutrient SensingHowever, in males, when obesity becomes obvious, the beta(3)-AR gene variant is considered to influence the enhancement of insulin resistance, in association with visceral obesity.11532330
Colorectal CarcinomaDeregulated Nutrient SensingMarkers of insulin resistance and colorectal cancer mortality.11535544
Colorectal Carcinoma, Congenital AbnormalityDeregulated Nutrient SensingOur analyses indicate that participants with high levels of blood glucose and a cluster of metabolic abnormalities linked to insulin resistance experienced a significant increased risk of colorectal cancer mortality compared with participants without the cluster.11535544
Increased insulin level, No metabolic abnormalities, Colorectal CarcinomaDeregulated Nutrient SensingOur findings are supportive of the hypotheses that glucose metabolism hyperinsulinemia, insulin resistance, and metabolic abnormalities associated with it may play a significant role in the etiology of colorectal cancer.11535544
Cardiovascular DiseasesDeregulated Nutrient SensingThese factors may contribute to the well-known relationship between insulin resistance and cardiovascular disease risk and might potentially become therapeutic targets in insulin resistant subjects.11549682
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingApoE4 allele is associated with obesity independent of dyslipidemia in women but not men with a family history of diabetes.11553047
Dyslipidemias, diabeticDeregulated Nutrient SensingThus, Gly15Gly polymorphism of apM-1 gene might play a role in dyslipidaemia in type 2 diabetic patients.11571669
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient Sensinghypertension, smoking, dyslipidemia and diabetes) and is more common in patients with cardiovascular disease.11573052
Hyperlipidemia, Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingThe most common inherited dyslipidemia, familial combined hyperlipidemia (FCHL), is associated with insulin resistance.11574425
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingPossible pleiotropic effects of this insulin sensitivity locus on dyslipidemias in FCHL remain to be elucidated.11574425
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, concomitant disease, SimultaneousDeregulated Nutrient Sensing56% had no concomitant disease, 36% had either diabetes, dyslipidemia or coronary heart disease, 8% had at least two concomitant diseases.11575213
Dyslipidemias, diabetic, Blood GlucoseDeregulated Nutrient SensingIn addition, 30% of patients with dyslipidemia reached the target LDL-C as defined by French recommendations (ANAES 1996) and 30% of the diabetic patients reached the target value for glycemia recommended by ADA (1997).11575213
Kidney Failure, Chronic, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is an independent factor affecting atherosclerotic arterial wall changes and cardiovascular events in ESRD.11576913
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingRisk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C. Our aims were to investigate the host and viral specific factors associated with diabetes mellitus (DM) and insulin resistance in chronic hepatitis C patients.11580152
Fibrosis Assessment, Hepatitis CDeregulated Nutrient SensingWe observed that insulin resistance in non-diabetic HCV-infected patients was related to grading of liver fibrosis, and occurs already at an early stage in the course of HCV infection.11580152
Hypertension, CTCAE, Endothelial dysfunction, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCerebrovascular risk factors, including hypertension, smoking, diabetes mellitus, aging, dyslipidemia, and hyperhomocyst(e)inemia are linked to endothelial dysfunction.11583722
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe rising prevalence of type 2 diabetes, a condition associated with insulin resistance, is commonly attributed to changes in dietary patterns and physical activity levels in susceptible populations.11586491
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingLow serum levels of high-density lipoprotein (HDL) cholesterol or apolipoprotein A-I and high serum levels of insulin increase the risk of coronary heart disease (CHD) and can indicate insulin resistance.11589836
Metabolic DiseasesDeregulated Nutrient SensingThe association of hepatic iron overload with metabolic disorders has been coined as the insulin resistance-associated hepatic iron overload syndrome (IR-HIO).11592595
ObesityDeregulated Nutrient SensingThis data suggests that increased phospholipid transfer protein activity in obese subjects is a consequence of obesity itself without the contribution of insulin resistance and can be explained by increased synthesis of phospholipid transfer protein from the enlarged mass of adipose tissue.11596664
Diabetes MellitusDeregulated Nutrient SensingOxidative stress could contribute to diabetes and its complications by predisposing to insulin resistance.11596674
ObesityDeregulated Nutrient SensingCoronary endothelial dysfunction indicated as CFVR, body fat distribution and insulin resistance was quantitatively correlated in obesity.11597360
Microalbuminuria, Cardiovascular Diseases, diabeticDeregulated Nutrient SensingMicro-albuminuria is associated with insulin resistance and a high blood pressure and predicts an increased risk of cardiovascular disease in both diabetic and non-diabetic populations.11598395
Microalbuminuria, Coronary heart diseaseDeregulated Nutrient SensingThe association between micro-albuminuria, insulin resistance, and coronary heart disease may be a consequence of growth retardation representing a common antecedent.11598395
diabeticDeregulated Nutrient SensingThis suggests that insulin resistance is not necessarily an essential component of Korean elderly lean diabetic women.11641528
Glucose Intolerance (disease), AcromegalyDeregulated Nutrient SensingRisk factors for glucose intolerance in active acromegaly.11668352
Glucose Intolerance (disease), Acromegaly, diabeticDeregulated Nutrient SensingIn the present retrospective study we determined the frequency of glucose intolerance in active untreated acromegaly, and searched for risk factors possibly supporting the emergence of the diabetic condition.11668352
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, the abnormal regulation of GCR mRNA is likely to play a significant role in the insulin resistance observed in obese patients with Type II diabetes.11672459
AtherosclerosisDeregulated Nutrient SensingCross-sectional analysis of the IRAS (Insulin Resistance Atherosclerosis Study), a large (n=1559) tri-ethnic population (non-Hispanic whites, African-Americans and Mexican-Americans) across different states of glucose tolerance.11673759
Increased insulin level, diabeticDeregulated Nutrient SensingThe purpose of this study was to explore the relation between insulin resistance and plasma levels of soluble adhesion molecules and to examine the effects of acute hyperinsulinemia on these molecules in type 2 diabetic individuals.11679465
diabeticDeregulated Nutrient SensingOverall adiposity, rather than insulin resistance, may be a determinant of plasma levels of ICAM-1 and E-selectin in type 2 diabetic individuals.11679465
Osteogenesis, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance is frequently found in patients with ossification of the posterior longitudinal ligament of the spine.11679606
Increased insulin levelDeregulated Nutrient SensingThese results suggest that the lipid characteristics in postmenopausal women might be associated with insulin resistance and/or hyperinsulinemia, and relative hyperandrogenicity which thus induces an increase in the amount of Free T and a decrease in the SHBG within physiological ranges.11686310
Dyslipidemias, Diabetes Mellitus, Coronary heart diseaseDeregulated Nutrient SensingAlthough individuals with diabetes mellitus frequently have dyslipidaemias and high blood pressure, much of the increased risk for coronary heart disease is not explained by these and other classical risk factors.11686665
Hyperglycemia, Dyslipidemias, Diabetic Angiopathies, Hypertension, CTCAEDeregulated Nutrient SensingCombined treatment of hyperglycaemia, dyslipidaemia and hypertension significantly decreases the frequency and severity of diabetic microvascular and macrovascular complications.11688065
Hypertension, CTCAE, Albuminuria, Dyslipidemias, diabeticDeregulated Nutrient SensingHypertension was diagnosed in 54% of the diabetic patients, albuminuria in 53% and dyslipidaemia in 47%; there were 40 smokers (17%).11688065
Increased insulin level, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNinety percent of patients had an increased body mass index (BMI), 35% had dyslipidemia, 40% had sub-clinical diabetes (only 3% had overt diabetes), 60% had hyperinsulinemia, and more than 90% had enhanced levels of lipid peroxidation markers.11690701
Increased insulin level, Steatohepatitis, Fatty degeneration, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Liver CirrhosisDeregulated Nutrient SensingOur data indicate that in our country, NAFLD may occur in young males with an increased BMI, with or without hyperinsulinemia, dyslipidemia and diabetes, generally associated with disorders of redox status, and that it may be differentiated from steatosis to steatohepatitis or cirrhosis only with a liver biopsy.11690701
ObesityDeregulated Nutrient SensingInsulin resistance in obesity: body-weight or energy balance?11691649
cardiovascular problemDeregulated Nutrient SensingIncreased red blood cell count could be considered as a new aspect of the insulin resistance syndrome that could contribute to the increased risk of developing cardiovascular problems.11692171
Nonalcoholic SteatohepatitisDeregulated Nutrient SensingNinety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease.11693332
Diabetes Mellitus, Fatty Liver DiseaseDeregulated Nutrient SensingDiabetes or insulin resistance were present in almost all in this cohort of patients with NASH.11693332
Diabetes MellitusDeregulated Nutrient SensingStudies of glucose tolerance demonstrated unsuspected diabetes in six, and insulin resistance (the hallmark of syndrome X) in 85% of those tested.11693332
Fatty Liver DiseaseDeregulated Nutrient SensingWe hypothesize that NASH is a disorder of genetic etiology and is the hepatic manifestation of syndrome X, the insulin resistance syndrome.11693332
DyslipidemiasDeregulated Nutrient SensingImprovement of HAART-associated insulin resistance and dyslipidemia after replacement of protease inhibitors with abacavir.11698228
Hypercholesterolemia, HypertriglyceridemiaDeregulated Nutrient SensingIn addition, a reversal of baseline insulin resistance, hypercholesterolemia and hypertriglyceridemia was observed in the majority of patients.11698228
DyslipidemiasDeregulated Nutrient SensingFor comparable BMI and age, healthy AIs have physiologic markers for insulin resistance, dyslipidemia, and increased cardiovascular risk, compared with Caucasians.11701707
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus.11701715
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSkeletal muscle insulin resistance (IR) is typically severe in type 2 diabetes mellitus (DM).11701715
Kidney Failure, Chronic, DyslipidemiasDeregulated Nutrient SensingWe conclude that fluvastatin may be used safely to correct dyslipidemia in patients with end-stage renal failure through the peri-transplant period.11703619
ObesityDeregulated Nutrient SensingThe adrenergic receptor system is involved in thermogenesis and in the activation of lipid mobilization in fat cells, and polymorphisms in the beta-2 and beta-3 adrenoceptor genes (BAR2 and BAR3) have been reported to be associated with obesity and insulin resistance.11706779
Blood GlucoseDeregulated Nutrient SensingThus, the odds ratio for insulin resistance was 5.9 for a glycemia >= 110 mg/dl, 2.6% for BMI >= 25 kg/m(2) and 2.2 for triglycerides >= 150 mg/dl.11707218
Coronary heart diseaseDeregulated Nutrient SensingLeg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study.11707479
Coronary heart diseaseDeregulated Nutrient SensingLeg length is the component of stature related to insulin resistance and coronary heart disease risk.11707479
Coronary heart diseaseDeregulated Nutrient SensingThe reported associations suggest that pre-adult influences are important in the aetiology of coronary heart disease and insulin resistance.11707479
Hypercholesterolemia, Dyslipidemias, Insulin, Diabetes MellitusDeregulated Nutrient SensingPolicosanol is a well defined mixture of higher aliphatic primary alcohols isolated from sugar cane wax with cholesterol-lowering effects proven for a dose range from 5-20 mg/day in patients with type II hypercholesterolemia and dyslipidemia associated with noninsulin dependent diabetes mellitus.11708574
Hypertension, CTCAEDeregulated Nutrient SensingImpaired endothelial function with decreased nitric oxide production is shared by insulin resistance and essential hypertension.11710784
Hypertension, CTCAEDeregulated Nutrient SensingThus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension.11710784
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingOf all the patients enrolled in the three trials, 38% were smokers, 25% had a history of myocardial infarction (MI) or stroke, and 52% had a history of dyslipidemia.11712773
Hypertension, CTCAEDeregulated Nutrient SensingStanford Asian-Pacific Program in Hypertension and Insulin Resistance.11715069
Tumor necrosisDeregulated Nutrient Sensing[The mechanism of tumor necrosis factor-alpha (TNF-alpha) induced insulin resistance by variation in promoter region of TNF-alpha gene].11715473
LipolysisDeregulated Nutrient SensingThe difference in the degree of lipolysis led by the variant of the promoter region of TNF-alpha may be one of the mechanisms for the variation in the degree of insulin resistance in general population.11715473
Glucose Intolerance (disease)Deregulated Nutrient SensingWe hypothesize that the mechanism by which clozapine may produce glucose intolerance may require a preexisting latent defect in insulin secretion and insulin action.11724088
Hypertension, CTCAEDeregulated Nutrient SensingCentral adiposity, insulin resistance and hypertension are clearly interrelated but the mechanisms underlying this association have not been thoroughly elucidated.11725158
DyslipidemiasDeregulated Nutrient SensingIncreased concentration of fibrinogen, dyslipidemia and impaired fibrinolysis are regarded as important risk factors for CVD.11728524
hormone-sensitive lipase activityDeregulated Nutrient SensingThis study provides additional evidence for a role for HSL in the development of insulin resistance, from which carriers of the -60G allele, associated here with markers of insulin sensitivity in women, and with lower NEFA levels in men, might be protected.11731226
Myocardial IschemiaDeregulated Nutrient SensingVariation in the TC/HDL-C ratio may be associated with more substantial alterations in metabolic indices predictive of ischemic heart disease risk and related to the insulin resistance syndrome than variation in the LDL-C/HDL-C ratio.11732933
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingThe objective of the present study was to present evidence that the LDL-C/HDL-C ratio may underestimate ischemic heart disease risk in overweight hyperinsulinemic patients with high triglyceride (TG)-low HDL-C dyslipidemia.11732933
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingReduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity.11734573
Increased insulin levelDeregulated Nutrient SensingIn conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia.11734573
ObesityDeregulated Nutrient SensingThe Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.11739459
ObesityDeregulated Nutrient SensingIn conclusion, the Q121 PC-1 variant and obesity have independent and additive effects in causing insulin resistance.11739459
Increased insulin level, Hypertriglyceridemia, Coronary heart disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingDecreased HDL-C is often associated with other coronary heart disease risk factors such as obesity, hyperinsulinemia and insulin resistance, hypertriglyceridemia and hypertension.11743583
DyslipidemiasDeregulated Nutrient SensingAlthough several genes have been identified for rare forms of dyslipidemia, the genes accounting for major variation in HDL-C levels have yet to be identified.11743583
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThe associations between hypertension, insulin resistance and glucose intolerance are poorly understood.11744037
Hypertension, CTCAEDeregulated Nutrient SensingThe association between hypertension and insulin resistance is unlikely to be explained by altered microvascular structure and function.11744037
Glucose Intolerance (disease), Diabetic Glomerulosclerosis, Diabetes MellitusDeregulated Nutrient SensingWe report on 3 patients without overt diabetes, but with glucose intolerance, all male, aged 43-66 years, with histological features of diabetic glomerulosclerosis.11744813
Coma (genus), Glucose Intolerance (disease), Diabetic KetoacidosisDeregulated Nutrient SensingThe severity of reported cases ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma.11747852
Increased insulin level, Hypertriglyceridemia, Hyperlipoproteinemia Type IDeregulated Nutrient SensingIn this family, hyperinsulinemia as a marker of insulin resistance may be a strong determinant of hypertriglyceridemia in the carrier with heterozygous LPL deficiency.11750290
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingIt is concluded that glucose intolerance and central obesity are common in this rural Central Asian community.11755475
Glucose Intolerance (disease), AniridiaDeregulated Nutrient SensingPAX6 mutation as a genetic factor common to aniridia and glucose intolerance.11756345
Abnormality, Glucose Intolerance (disease)Deregulated Nutrient SensingTaken together, our present observations suggest that heterozygous mutations in the PAX6 gene can induce eye anomaly and glucose intolerance in individuals harboring these mutations.11756345
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingAtherosclerosis is associated with insulin resistance (IR) and dyslipidaemia.11757080
No metabolic abnormalities, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to compare the leptin concentration, and its relationship with some anthropometric and biochemical parameters related to insulin resistance in 140 moderately obese type 2 diabetics (T2DM) and 160 age and weight matched non-diabetic controls in order to get a better insight into the possible role of leptin in the metabolic abnormalities of diabetes.11762704
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingAlthough mean blood pressure and blood lipids were up to recently deemed adequate, a (too) high proportion of diabetic patients exhibited either hypertension and/or dyslipidaemia according to revised therapeutic goals cut-offs.11770224
Inflammation, Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingOur study investigated whether familial hypoalphalipoproteinemia, a genetic form of dyslipidemia characterized by very low HDL levels, might be associated with increased inflammation markers such as C-reactive protein.11772869
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow testosterone levels in men and high testosterone levels in women predict insulin resistance and incident type 2 diabetes in older adults.11772901
ObesityDeregulated Nutrient SensingLeptin is important for the control of body weight and has been proposed to be a link between obesity and the insulin resistance syndrome.11775042
Hyperleucinemia, OverweightDeregulated Nutrient SensingHyperleptinemia can be an important link in the development of overweight and the insulin resistance syndrome in subjects receiving antipsychotic drugs, especially atypical agents like clozapine.11775042
HyperlipidemiaDeregulated Nutrient SensingLaboratory investigation revealed a type V hyperlipidemia pattern, insulin resistance, and high alpha-tocopherol levels.11781404
Hypertensive (finding), Insulin resistance syndromeDeregulated Nutrient Sensing[Study on relationship between insulin-resistance and syndrome differentiation typing in hypertensive patients].11783264
Hypertensive (finding)Deregulated Nutrient SensingTo find the relationship between insulin-resistance and Syndrome Differentiation typing (SDT) in hypertensive patients.11783264
Hypertensive (finding)Deregulated Nutrient Sensing(1) Compared with healthy subjects, all hypertensive patients had apparent insulin resistance (P < 0.05).11783264
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance is one of the pathological basis for SDT in hypertension.11783264
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes MellitusDeregulated Nutrient SensingWith the purpose of determining how certain risk factors for type 2 diabetes such as family history of diabetes, obesity and dyslipidemia, affect the glucose-insulin response to a glucose challenge, 135 individuals (77 women and 58) men were studied.11787271
DyslipidemiasDeregulated Nutrient SensingDyslipidemia increased the basal and post challenge glucose insulin values only in men (p < 0.002).11787271
Increased insulin level, Dyslipidemias, Diabetes Mellitus, Obesity, DeficitDeregulated Nutrient SensingWe conclude that, without alteration of the glycemic response, the presence of risk factors as obesity, dyslipidemia or family history of diabetes leads to basal hyperinsulinemia, as well as glucose stimulated hyperinsulinemia, however the coexistence of obesity and family history of diabetes, is responsible for a deficit in the insulin secretion by the pancreas.11787271
ObesityDeregulated Nutrient SensingInhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity.11788478
AtherosclerosisDeregulated Nutrient SensingInsulin resistance is associated with an increased risk of atherothrombotic vascular disease, but the mechanisms are poorly understood.11788478
ObesityDeregulated Nutrient SensingInsulin resistance and the persistence of obesity from childhood into adulthood.11788625
ObesityDeregulated Nutrient SensingInsulin resistance and obesity are associated in children as they are in adults.11788625
Weight GainDeregulated Nutrient SensingHowever, although insulin resistance seems to oppose further weight gain in adults, opposite results have been found in children.11788625
ObesityDeregulated Nutrient SensingIn boys, insulin resistance was not a significant predictor of adult obesity.11788625
ObesityDeregulated Nutrient SensingIn obese girls, insulin resistance during childhood appears to oppose the risk of obesity in adulthood.11788625
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAffected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.11788685
Dyslipidemias, Occlusion of artery (disorder)Deregulated Nutrient SensingIn patients with arterial occlusion of the lower extremities with baseline dyslipidaemia statin treatment proved protective, i.e.11789002
Increased insulin levelDeregulated Nutrient SensingTo study the relationship between insulin-resistance (IR), hyperinsulinemia and TCM Syndrome Differentiation-typing.11789282
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular disease (CVD) is associated with dyslipidemia and frequently with insulin resistance, both of which are in general no alleviated by antilipidemic drugs.11789299
HyperglycemiaDeregulated Nutrient SensingSubjects with isolated 2 h hyperglycaemia were mainly characterised by normal basal insulin secretion and by a marked insulin resistance associated with a blunted first-phase insulin secretion after the glucose load.11791152
Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, HereditaryDeregulated Nutrient SensingType 2 diabetes mellitus is a heterogeneous inherited disorder characterized by chronic hyperglycemia resulting from pancreatic beta-cell dysfunction and insulin resistance.11791216
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate the protein expression of insulin receptor substrate-1 (IRS-1), protein tyrosine phosphatase with two src-homology 2 (SH-PTP(2)) in adipose tissues of type II diabetic patients, and explore molecular mechanisms of insulin resistance from adipose tissues of type II diabetic individuals.11798533
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe abnormal changes in expression of IRS-1 and SH-PTP(2) protein in adipose tissues of the patients with type II diabetic mellitus may be one of the mechanisms of leading to insulin resistance.11798533
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe abdominal subcutaneous adipose tissue of type II diabetic patients, as visceral adipose tissues, contributes to their insulin resistance.11798533
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient Sensing[Dyslipidemia-related risk factors for myocardial infarction and polymorphism of ApoE gene among myocardial infarction patients and their siblings].11798896
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia is an important risk factor for MI, and polymorphism of ApoE may be an indirect risk factor of coronary heart disease genetically.11798896
DyslipidemiasDeregulated Nutrient SensingLipid values obtained from portable lipid analyzers may be useful for screening, but they should not be used to make clinical decisions regarding the diagnosis and management of dyslipidemia in individual patients.11805009
Premenopause, OverweightDeregulated Nutrient SensingHomocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausal women.11806465
Prostate Cancer Outcomes Study, Precocious pubarche, Pancreatic Polypeptide, Polycystic Ovary SyndromeDeregulated Nutrient SensingIn both obese and nonobese women, polycystic ovary syndrome (PCOS) is essentially a disorder of hyperinsulinemic insulin resistance, and it may be heralded by precocious pubarche (PP; appearance of pubic hair in girls aged <8 y).11809921
Fetal Growth Retardation, Glucose Intolerance (disease), Islets of LangerhansDeregulated Nutrient SensingGlucose intolerance in adults born with intrauterine growth retardation (IUGR) may involve peripheral insulin resistance and/or abnormal endocrine pancreas development during fetal life.11812745
Inflammation, Diabetes MellitusDeregulated Nutrient SensingChronic low-grade inflammation may be involved in the pathogenesis of insulin resistance and type 2 diabetes.11812755
Breast CarcinomaDeregulated Nutrient SensingThis study supports the hypothesis of moderate, direct associations between glycemic index or glycemic load and breast cancer risk and, consequently, a possible role of hyperinsulinemia/insulin resistance in breast cancer development.11822751
Aortic Stiffness, Carotid Intima-Media ThicknessDeregulated Nutrient SensingIn these elderly participants, aortic stiffness was positively associated with risk factors associated with the insulin resistance syndrome, increased common carotid intima-media thickness, heart rate, and decreased physical activity measured several years earlier.11824854
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingA significant correlation has been demonstrated in adults between WBC counts and some risk factors for coronary heart disease (CHD), including insulin resistance.11831107
diabeticDeregulated Nutrient SensingFrom these results, it can be concluded that short-term (7 days) low-intensity physical exercise combined with hospital diet reduces serum triglycerides, insulin resistance, and fasting glucose levels without affecting BMI in non-obese Japanese type 2 diabetic patients.11832998
Hypertension, CTCAE, Ischemic stroke, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTo prevent ischemic stroke, strict control of diabetes, hypertension, and dyslipidemia and monitoring of CCA-IMT may be important.11833056
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity, diabetes, alcohol, dyslipidaemia and family history were important determinants of hypertension.11837752
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is universal but hypercholesterolemia per se is present in around 50% of dialysis patients.11840368
Hypotension, diabeticDeregulated Nutrient SensingInsulin resistance is associated with reduced nocturnal falls of blood pressure in normotensive, nonobese type 2 diabetic subjects.11848170
diabeticDeregulated Nutrient SensingThus, our results suggest that insulin resistance is associated with decreased nocturnal BP fall in type 2 diabetic subjects.11848170
Dyslipidemias, diabeticDeregulated Nutrient SensingCoronary risk and dyslipidemia in type 2 diabetic patients.11848328
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingA prospective study was carried out to find out the percentage of dyslipidemia in type 2 diabetics, to study the pattern of dyslipidemia, categorize the levels of LDL, HDL and triglycerides into higher, borderline and lower risk of developing coronary heart disease in type 2 diabetics and to compare the lipid profile with non-diabetics.11848328
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe major concern which our study highlights is the high percentage of LDL dyslipidemia majority of whom fell in higher risk of developing CHD.11848328
DyslipidemiasDeregulated Nutrient SensingThese studies suggest a mechanism linking central obesity with insulin resistance and dyslipidaemia.11850747
Acquired Immunodeficiency Syndrome, DyslipidemiasDeregulated Nutrient SensingLipid metabolism is partly regulated by both steroid hormones and cytokines and we have previously reported that dyslipidaemia in LD-positive men is correlated to an increase in cortisol : DHEA ratio (Christeff et al., AIDS 1999;13:2251).11851726
Dyslipidemias, ObesityDeregulated Nutrient SensingGlycaemic control and obesity are the major determinants of diabetic dyslipidaemia in Hong Kong Chinese.11852371
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidaemia plays a major role in the increased mortality in diabetes.11852371
Hypoglycemia, Dyslipidemias, Obesity, diabeticDeregulated Nutrient SensingWith multiple regression analysis (stepwise), dyslipidaemia was mainly associated with glycaemia, obesity and age in diabetic patients, and obesity, male gender and age in non-diabetic subjects.11852371
Dyslipidemias, diabeticDeregulated Nutrient SensingWe have confirmed the high prevalence and increased risk of dyslipidaemia in Chinese type 2 diabetic patients.11852371
Myocardial IschemiaDeregulated Nutrient SensingExacerbation of the proinflammatory process may be a mechanism whereby a high intake of rapidly digested and absorbed carbohydrates increases the risk of ischemic heart disease, especially in overweight women prone to insulin resistance.11864854
Inflammation, DyslipidemiasDeregulated Nutrient SensingIncreased levels of adhesion molecules are associated with inflammation, dyslipidaemia, and cardiovascular events.11865089
palladium, Dyslipidemias, Peritonitis, Cardiovascular DiseasesDeregulated Nutrient SensingDifferent comorbidity factors such as the presence of cardiovascular disease, age over 70 and dyslipidemia at the start of PD were analyzed as well as the incidence of peritonitis, the peritonitis-free interval, need for hospitalization, mortality rate, early mortality rate, survival curves (log rank) and the impact factor (Cox) on mortality for the different variables.11867950
Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe did not find a significantly different percentage of diabetes, smoking, hypertension, dyslipidemia, myocardial infarction, and previous transient ischemic attack between the 2 groups of patients.11872889
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingAlthough children and adolescents with type 1 DM seem not to show alterations in cardiac mass and function or early atherosclerotic changes in the first few years after diagnosis, their cardiovascular risk is increased as they present with dyslipidemia at an early stage of the disease.11874183
Glucose Intolerance (disease), ThalassemiaDeregulated Nutrient SensingAcarbose is a well-tolerated agent for the management of thalassemic patients with glucose intolerance and normal or increased insulin secretion.11874186
Cardiovascular DiseasesDeregulated Nutrient SensingSecondary dyslipidaemia in pHPT has attracted little attention, although morbidity and mortality associated with cardiovascular diseases have been reported to be increased in these patients.11874418
DyslipidemiasDeregulated Nutrient SensingProatherosclerotic dyslipidaemia characterizes mild pHPT and is effectively reversed by parathyroidectomy.11874418
Cessation of life, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingAs dyslipidaemia might contribute to the increased risk of cardiovascular diseases and death observed in pHPT, the findings favour operative intervention rather than conservative surveillance in mild, asymptomatic pHPT in postmenopausal females.11874418
Sleep Apnea, ObstructiveDeregulated Nutrient SensingObstructive sleep apnea is independently associated with insulin resistance.11874812
Atherosclerosis, Osage languageDeregulated Nutrient SensingInsulin resistance is a known risk factor for atherosclerosis, and we postulate that OSA represents a stress that promotes insulin resistance, hence atherogenesis.11874812
Sleep Disorders, Osage languageDeregulated Nutrient SensingOur findings suggest that OSA is independently associated with insulin resistance, and its role in the atherogenic potential of sleep disordered breathing is worthy of further exploration.11874812
OverweightDeregulated Nutrient SensingSleep-disordered breathing and insulin resistance in middle-aged and overweight men.11874813
ObesityDeregulated Nutrient SensingMultivariable linear regression analyses revealed that increasing AHI was associated with worsening insulin resistance independent of obesity.11874813
Sleep-Disordered Breathing, Glucose Intolerance (disease)Deregulated Nutrient SensingThus, sleep-disordered breathing is a prevalent condition in mildly obese men and is independently associated with glucose intolerance and insulin resistance.11874813
Increased insulin level, Dyslipidemias, Gall Bladder Diseases, ObesityDeregulated Nutrient SensingHyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease.11880221
Increased insulin level, Dyslipidemias, Gall Bladder Diseases, ObesityDeregulated Nutrient SensingIn men, hyperinsulinemia and dyslipidemia may have some role in the etiology of gallbladder disease beyond their association with obesity, whereas in women, increased body size, central adiposity, and hormone replacement therapy may be more important determinants of gallbladder disease.11880221
Tumor necrosisDeregulated Nutrient SensingTumor necrosis factor-alpha (TNF-alpha) is increasingly recognized as a key component in the development of insulin resistance and increased blood pressure.11882518
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients.11886934
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur data indicate that both obese non-diabetic and obese type 2 diabetic patients have a blunted suppressive action of insulin on glucose production, indicating hepatic and renal insulin resistance.11886934
Glucose Intolerance (disease)Deregulated Nutrient SensingOur research suggests that ApaI polymorphism may be associated with glucose intolerance independent of defective insulin secretion and BsmI polymorphism with insulin resistance in a nondiabetic Caucasian population.11887173
Cushing SyndromeDeregulated Nutrient SensingThe slight hypercortisolism observed in some such patients may significantly contribute to this state of insulin resistance.11889151
Chronic heart failureDeregulated Nutrient SensingDifferentiation of the metabolic and vascular effects of insulin in insulin resistance in patients with chronic heart failure.11897212
Chronic heart failureDeregulated Nutrient SensingChronic heart failure (HF) is associated with insulin resistance.11897212
Dyslipidemias, Diabetes Mellitus, Cardiac complication, Obesity, OverweightDeregulated Nutrient SensingPatients aged 55 and older with newly diagnosed isolated systolic AH had the following most common factors of risk of cardiovascular complications: overweight, obesity, smoking, dyslipidemia, diabetes mellitus.11899825
Dyslipidemias, Overweight, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn treated patients these risk factors are: overweight, obesity, dyslipidemia, diabetes mellitus, smoking.11899825
Central visual impairment, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingIn IHD without CVI dyslipidemia in most cases was associated with one of the additional risk factors (hypertension, smoking, diabetes mellitus) while in CVI it combined with two or three additional risk factors.11899828
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin or insulin resistance is considered a coronary heart disease (CHD) risk factor, but proinsulin may have a stronger association with CHD than insulin.11901041
Hyperinsulinism, DyslipidemiasDeregulated Nutrient SensingSmoking was also associated with hyperinsulinaemia, dyslipidaemia and high blood pressure, i.e.11902817
Arthritis, DyslipidemiasDeregulated Nutrient SensingThe acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis.11908557
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThis may relate to insulin resistance and dyslipidemia, which were both reported to correlate with the acute phase response in RA.11908557
Arthritis, DyslipidemiasDeregulated Nutrient SensingWe investigated whether insulin resistance and dyslipidemia could be explained by the acute phase response as well as excess weight in inflammatory arthritis.11908557
Arthritis, DyslipidemiasDeregulated Nutrient SensingInsulin resistance and dyslipidemia were highly prevalent in patients with inflammatory arthritis.11908557
Malignant neoplasm of endometriumDeregulated Nutrient SensingInitiation and/or promotion of endometrial cancer is known to be associated with estrogen and androgen (androstenedione) excess as well as with hyperinsulinemia/insulin resistance.11911969
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and Type II diabetes share common associations with retarded fetal growth and accelerated growth during childhood.11914739
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThey are dissimilar, however, in that insulin resistance is associated with thinness in childhood and low maternal BMI, while Type II diabetes is associated with high BMI in childhood and high maternal BMI.11914739
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn individuals with type 2 diabetes, these regular variations are altered, which has been implicated in the development of insulin resistance and hyperglycemia.11916916
ObesityDeregulated Nutrient SensingObesity is associated with insulin resistance, particularly when body fat has a central distribution.11916919
Cardiovascular morbidity, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIndividuals with chronic renal disease are at high risk of cardiovascular morbidity and mortality, and therefore the management of dyslipidemia is particularly important in this patient population.11918754
Diabetes MellitusDeregulated Nutrient SensingThe relationship between parity and risk of diabetes is controversial, and little information is available regarding associations between parity and measures of insulin resistance and beta-cell function.11919126
Diabetic Retinopathy, Dyslipidemias, diabeticDeregulated Nutrient SensingPro12Ala polymorphism of PPAR(gamma2) gene is not associated with diabetic retinopathy but is associated with dyslipidemia in male type 2 diabetic patients.11928067
Increased insulin level, Carcinogenesis, Dyslipidemias, Complications of Diabetes Mellitus, Diabetes Mellitus, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEspecially hyperinsulinemia as an independent secondary risk factor for hypertension, dyslipidemia--in consequences late diabetic complications and perhaps carcinogenesis may play an important role as a predictor of diabetes type 2 and biochemical marker of effectiveness of non-pharmacological and pharmacological approach in the global concept of diabetes type 2 treatment (Z. Szybinski).11928582
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingOf them diabetes was confirmed in 11 patients, impaired glucose tolerance was observed in 9, and glucose intolerance was excluded in 22 subjects.11928585
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingDepending on a contribution of the primary risk factors of type 2 Diabetes Mellitus (2-DM) mainly genetic factors and obesity--an independent cause of insulin receptor resistance--glucose intolerance and 2-DM may overlap the Syndrome X.11928588
Glucose Intolerance (disease)Deregulated Nutrient SensingIn the persons with glucose intolerance and new-diagnosed 2-DM insulinemia increased 2-3 fold depending on BMI, and gender.11928588
Increased insulin level, Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingObesity and insulinemia in 2 h-OGTT in multiple analysis have been identified as a strong predictors and risk factors of impaired glucose intolerance (IGT) 2-DM fasting insulinemia may be useful as an indicator of the peripheric insulin receptor resistance.11928588
TG gene, Microunit per MilliliterDeregulated Nutrient SensingDespite a significant fall in fasting insulin levels (9.9 to 8.3 mU/l, range 8.85-19.8 to 6.33-11.6, P < 0.001) and insulin resistance (2.7 to 1.9, range 1.2-10.4 to 1-6.2, P < 0.001), mean serum TG and HDL levels were unaffected by IGF-I normalization.11940041
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe study included 45 patients with type 2 diabetes mellitus and dyslipidemia; 31 of these patients received a TZD (troglitazone), and 14 patients received metformin.11942773
HyperleucinemiaDeregulated Nutrient SensingOverweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia.11943833
Hyperleucinemia, OverweightDeregulated Nutrient SensingTo evaluate the influence of overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia.11943833
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLight-to-moderate alcohol consumption is associated with a lower prevalence of type 2 diabetes, reduced insulin resistance, and more favorable vascular risk profile in the severely obese.11943832
Acute Cerebrovascular AccidentsDeregulated Nutrient Sensing[Relation between insulin-like growth factor-1 and insulin resistance in patients with acute stroke].11953210
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingFasting plasma glucose concentration was an inadequate parameter in diagnosing diabetes and intermediate categories of glucose intolerance in our cohort of subjects.11957556
ObesityDeregulated Nutrient SensingDairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study.11966382
Hyperinsulinism, Polycystic Ovary Syndrome, ObesityDeregulated Nutrient SensingHyperinsulinaemia and insulin resistance are usually associated phenomena of obesity and the polycystic ovary syndrome (PCO syndrome).11968579
diabeticDeregulated Nutrient SensingIn conclusion, serum thioredoxin levels may reflect the status of insulin resistance in Type 2 diabetic patients.11972307
Hyperproinsulinemia, Blood Glucose, Diabetes MellitusDeregulated Nutrient SensingHyperproinsulinemia and proinsulin-to-insulin ratios in Swedish middle-aged men: association with glycemia and insulin resistance but not with family history of diabetes.11978587
Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingThese findings indicate that elevated proinsulin and proinsulin/insulin ratios are secondary to increased demands on beta-cell secretion induced by hyperglycemia and insulin resistance with no discernible influence of family history of diabetes.11978587
Peripheral Vascular Diseases, Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingHyperglycemia, as well as smoking, dyslipidemia, and blood pressure are potentially modifiable risk factors for the development of PVD.11978687
diabeticDeregulated Nutrient SensingRelationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients.11979383
diabeticDeregulated Nutrient SensingFrom these results, it can be suggested that (1) both subcutaneous and visceral abdominal fat areas are independently associated with insulin resistance and (2) visceral fat area, but not the subcutaneous one, is associated with serum triglyceride levels in our nonobese Japanese type 2 diabetic patients.11979383
Hypertensive (finding)Deregulated Nutrient SensingWe conclude that in lean, postmenopausal hypertensive women insulin resistance is increased compared with age- and weight-matched normotensive women.11986914
Hypertensive (finding)Deregulated Nutrient SensingThus, insulin resistance may possibly be involved as a pathogenetic factor in lean, postmenopausal hypertensive women.11986914
Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Dyslipidemia and cardiovascular risk in type 2 diabetes mellitus patients with associated diabetic nephropathy].11987671
Proteinuria, Microalbuminuria, Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Cardiac complicationDeregulated Nutrient SensingDiabetes patients with concomitant diabetic nephropathy are especially destined to cardiovascular complications due to the presence of microalbuminuria or proteinuria, that are potent inductors of dyslipidaemia.11987671
Diabetic Nephropathy, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSince dyslipidaemia is closely related to the progression of cardiovascular disease and mortality, an aggressive lipid-lowering therapy is recommended, irrespectively of its potential effect on diabetic nephropathy.11987671
Lipodystrophy, Complication AspectsDeregulated Nutrient SensingOur results indicate that serum adiponectin and leptin levels are extremely low in patients with generalized lipodystrophies and may be related to severe insulin resistance and its metabolic complications in lipodystrophies.11994394
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe role of diminished beta cell reserve and insulin resistance in secondary sulfonylurea failure of type 2 diabetes mellitus.11999824
Failure, diabeticDeregulated Nutrient SensingThe objectives of this study were to determine beta cell secretory reserve and insulin resistance of secondary SU failure type 2 diabetic patients who had fairly good glycemic control compared with those who were SU responsive and the disparity of beta cell responses to glucose and non-glucose stimuli were examined in these two groups.11999824
Thrombosis, Hypertension, CTCAE, Retinal Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMagnesium deficiency is common in type 2 diabetes and may have a negative impact on glucose homeostasis and insulin resistance, as well as on the evolution of complications such as retinopathy, thrombosis and hypertension.12001011
ObesityDeregulated Nutrient SensingTo determine whether racial differences in insulin resistance between African American (AA) and white women exist in postmenopausal women and whether they are related to physical fitness and/or obesity.12006632
Diabetic NephropathyDeregulated Nutrient SensingKK-Ay mice with insulin resistance and high urine mAlb level might be useful as models for the early stage of diabetic nephropathy.12012732
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Reference value and cut-off value for diagnosis of insulin resistance in type 2 diabetes mellitus].12014020
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese values should be available for the diagnosis of insulin resistance in type 2 diabetes mellitus.12014020
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingWe studied 20 non-diabetic hypertensive patients with mixed dyslipidaemia in whom serum metabolic parameters, including uric acid levels in serum and urine, were measured before and after eight weeks of indapamide administration (2.5 mg once daily).12017210
deficiency aspects, Diabetes Mellitus, Insulin-Dependent, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Autoimmune reactionDeregulated Nutrient SensingWhereas the pathogenesis of type 1 diabetes results from the autoimmune destruction of beta cells, leading to insulin deficiency, in type 2 diabetes insulin resistance as well as impaired insulin secretion are present; mechanisms that interact closely in the development of glucose intolerance.12017759
Dyslipidemias, Hypertension, CTCAE, vinyltriethoxysilaneDeregulated Nutrient SensingCigarette smoking, hypertension, dyslipidemia, physical inactivity, and alcohol consumption were not associated with risk of VTE.12020191
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingRisk factors include smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity.12022485
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingHigher ALT concentrations were cross-sectionally associated with obesity and whole-body and hepatic insulin resistance and prospectively associated with a decline in hepatic insulin sensitivity and the development of type 2 diabetes.12031978
Short statureDeregulated Nutrient SensingShortness at birth is associated with insulin resistance in pre-pubertal Jamaican children.12032649
Short statureDeregulated Nutrient SensingShortness at birth is related to insulin resistance.12032649
diabeticDeregulated Nutrient SensingThe diabetic patient showed insulin resistance, low AIR(Glucose), and low Sg.12037739
Chronic progressive external ophthalmoplegia, Diabetes MellitusDeregulated Nutrient SensingOvert diabetes in CPEO seems to be a combination of insulin resistance, an insulin secretion defect, and impaired glucose effectiveness.12037739
MicroalbuminuriaDeregulated Nutrient SensingAssociation of the insulin resistance syndrome and microalbuminuria among nondiabetic native Americans.12039992
MicroalbuminuriaDeregulated Nutrient SensingThis study investigated the association between microalbuminuria and the insulin resistance syndrome (IRS) among nondiabetic Native Americans.12039992
Glucose Intolerance (disease), Hypertension, CTCAE, Cardiovascular renal disease, ObesityDeregulated Nutrient SensingHealth promotion efforts should focus on lowering the prevalence of hypertension, as well as glucose intolerance and obesity, in this population at high risk for renal and cardiovascular disease.12039992
Atherosclerosis, Peripheral arterial occlusive disease, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingMany risk factors (age, hypertension, diabetes, tobacco use, dyslipidemia, etc) have been associated with atherosclerosis and the development of peripheral arterial occlusive disease.12042719
Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia.12047397
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingHypoalphalipoproteinemia (HALP) is a dyslipidemia characterized by low HDL-cholesterol (HDL-C) levels with important genetic contribution.12048121
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms via which pioglitazone improves insulin resistance in patients with type 2 diabetes mellitus.12050251
Dyslipidemias, Intermediate density lipoprotein cholesterol measurement (procedure), atheroscleroticDeregulated Nutrient SensingWe conclude that increasing the dose of atorvastatin leads to dose-dependent, preferential and progressive reduction in particle numbers of atherogenic VLDL-2, IDL and dense LDL, and concomitantly, to enhanced cellular cholesterol efflux in type IIB dyslipidemia, thereby diminishing the atherosclerotic burden in subjects characterised by high cardiovascular risk.12052475
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingTo evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS).12057717
Glucose Intolerance (disease)Deregulated Nutrient SensingOur data suggest that glucose intolerance should precede lipid intolerance.12059096
Cessation of life, Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingInsulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death.12060058
Cessation of life, Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingTo compare the incidence of myocardial infarction and death in non-diabetic subjects with and without insulin resistance.12060058
Cessation of life, Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingInsulin resistance, as assessed by the HOMA method, was in this cohort of middle-aged non-diabetic subjects associated with an increased incidence of myocardial infarction and death.12060058
Hypertension, CTCAEDeregulated Nutrient SensingConsidering the conditions of principal interest-glucose intolerance, hypertension and obesity-one-half of all subjects demonstrated one or more of these conditions.12060063
Glucose Intolerance (disease), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingCentral obesity was the most common condition, followed by hypertension and then glucose intolerance.12060063
Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus results from an inadequate adaptation of the functional pancreatic beta cell mass in the face of insulin resistance.12060768
Hyperlipidemia, LipoatrophyDeregulated Nutrient SensingWe performed an observational study in which efavirenz was substituted for a PI for 41 patients receiving HAART who had prolonged virus suppression, clinical signs of severe lipoatrophy, hyperlipidemia, and insulin resistance.12060877
Hyperlipidemia, LipoatrophyDeregulated Nutrient SensingWe conclude that, for PI-treated patients who present with lipoatrophy, hyperlipidemia, and insulin resistance, substituting efavirenz for PIs can maintain virus suppression and immunologic response to HAART, but it does not improve the lipid profile or resolve insulin resistance or lipoatrophy.12060877
Diabetes MellitusDeregulated Nutrient SensingIncreased plasma atrial natriuretic peptide (ANP) levels and impaired ANP action have been reported in patients with diabetes or insulin resistance.12063641
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is present in patients with Type 2 diabetes mellitus as well as in obese patients without diabetes.12071295
Hypertensive (finding), HypertriglyceridemiaDeregulated Nutrient SensingExacerbation of insulin resistance and postprandial triglyceride response in newly diagnosed hypertensive patients with hypertriglyceridaemia.12080433
TG gene, Hypertensive (finding), HypertriglyceridemiaDeregulated Nutrient SensingThe purpose of the study is to examine the differences in insulin resistance and postprandial triglyceride (TG) response between hypertensive patients with or without hypertriglyceridaemia.12080433
HypertriglyceridemiaDeregulated Nutrient SensingThe results provide a rationale for the alleviation of insulin resistance and hypertriglyceridaemia in these atherosclerosis-prone hypertensive patients.12080433
Inflammation, Hyperinsulinism, DyslipidemiasDeregulated Nutrient SensingMen were centrally more obese and had increased markers of endothelial activation, inflammation and the anti-fibrinolytic state as well as hyperinsulinaemia and dyslipidaemia, compared with women.12080455
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe association between insulin resistance (IR) and obesity and its causal relationship with type 2 diabetes is well recognized.12082884
Steatohepatitis, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCorrelations with weight parameters and pre-existing co-morbidities including diabetes, hypertension, dyslipidemia and hepatic steatosis were made.12082884
diabeticDeregulated Nutrient SensingIn all four ethnic groups (African-American, n = 55; Asian-American, n = 66; Caucasian, n = 217; Hispanic-American, n = 193), IFG/IGT and diabetic subjects exhibited progressively increasing insulin resistance and decreasing beta-cell function.12086947
Beta-Cell Function MeasurementDeregulated Nutrient SensingBoth insulin resistance and impaired beta-cell function are associated with impaired glucose metabolism in all ethnic groups, with beta-cell function seeming to be more important in determining glucose disposal.12086947
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.12086969
Hyperglycemia, No metabolic abnormalities, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThus, the results of the present study emphasizes the importance of other underlying metabolic abnormalities, such as abdominal obesity and related atherogenic dyslipidemia, in the modulation of the CAD risk associated with hyperglycemia.12088772
Kidney Failure, ChronicDeregulated Nutrient SensingInsulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease.12089386
AtherosclerosisDeregulated Nutrient SensingInsulin resistance is closely associated with atherosclerosis and cardiovascular mortality in the general population.12089386
Kidney Failure, Chronic, AtherosclerosisDeregulated Nutrient SensingPatients with end-stage renal disease (ESRD) are known to have insulin resistance, advanced atherosclerosis, and a high cardiovascular mortality rate.12089386
Kidney Failure, Chronic, Cardiovascular systemDeregulated Nutrient SensingWe evaluated whether insulin resistance is a predictor of cardiovascular death in a cohort of ESRD.12089386
Kidney Failure, ChronicDeregulated Nutrient SensingThese results indicate that insulin resistance is an independent predictor of cardiovascular mortality in ESRD.12089386
Dyslipidemias, Overweight, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient Sensingdiabetes without overweight, dyslipidaemia and hypertension) is a condition of insulin resistance.12099955
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingOverweight, central fat distribution, dyslipidaemia, hypertension and poor glycometabolic control are strong independent predictors of insulin resistance in Type 2 diabetes.12099955
Dyslipidemias, ObesityDeregulated Nutrient SensingSubjects, who had dyslipidemia or obesity, were instructed to walk (consecutive 60 minutes, one times daily) and to consume no more than 20% total fat and 300 mg/d of cholesterol for four weeks.12101821
Hyperleucinemia, Sleep Apnea, ObstructiveDeregulated Nutrient SensingInsulin resistance, hyperleptinemia, and obstructive sleep apnea in Launois-Bensaude syndrome.12105284
Hyperleucinemia, Sleep Apnea, Obstructive, Obesity, Osage languageDeregulated Nutrient SensingObesity is known to be closely associated with insulin resistance, hyperleptinemia, and obstructive sleep apnea (OSA).12105284
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingFamily and personal history of diabetes, hypertension, coronary heart disease, dyslipidemia, obesity, and biochemical data were compared between groups.12105842
Lipodystrophy, Steatohepatitis, LEPTIN DEFICIENCY OR DYSFUNCTION, HypertriglyceridemiaDeregulated Nutrient SensingSevere lipodystrophy is associated with leptin deficiency and insulin resistance, hypertriglyceridemia, and hepatic steatosis.12107209
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPolymorphism in the calpain-10 gene is linked to type 2 diabetes, insulin resistance, and decreased thermogenesis.12107250
Obesity, diabeticDeregulated Nutrient SensingHyperglycaemic siblings of Type II (non-insulin-dependent) diabetic patients have increased PAI-1, central obesity and insulin resistance compared with their paired normoglycaemic sibling.12107743
diabeticDeregulated Nutrient SensingFirst-degree relatives of Type II (non-insulin-dependent) diabetic patients in cross-sectional studies have increased insulin resistance, associated cardiovascular risk factors and abnormalities of fibrinolysis and coagulation.12107743
Gammopathy, DyslipidemiasDeregulated Nutrient SensingIn her history, we noted right optic neuritis, monoclonal gammopathy and dyslipidemia treated by fenofibrate.12108181
Hypertensive (finding)Deregulated Nutrient SensingThese results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI.12109775
Nephrotic Syndrome, DyslipidemiasDeregulated Nutrient SensingPatients with nephrotic syndrome have impaired endothelial function probably related to dyslipidemia.12110017
Dyslipidemias, Nephrotic SyndromeDeregulated Nutrient SensingStatin therapy significantly improves dyslipidemia and brachial artery endothelial function in patients with nephrotic syndrome.12110017
Dyslipidemias, Endothelial dysfunction, Nephrotic Syndrome, Cardiovascular DiseasesDeregulated Nutrient SensingThe findings also suggest a role for dyslipidemia in endothelial dysfunction and the risk for cardiovascular disease in nephrotic syndrome.12110017
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia characterised by increased levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides was obeserved in 64%, 12% and 44% of the teenagers, respectively.12113288
DyslipidemiasDeregulated Nutrient SensingThe observation that many dialysis patients receiving lipid-lowering therapy had not achieved recommended LDL-C and TC levels suggests that more efficient treatment of dyslipidaemia may be indicated in this patient population.12113597
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpaired insulin action is a key feature of type 2 diabetes and is also found, to a more extreme degree, in familial syndromes of insulin resistance.12118251
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThat mutant molecules primarily involved in either carbohydrate or lipid metabolism can combine to produce a phenotype of extreme insulin resistance provides a model of interactions among genes that may underlie common human metabolic disorders such as type 2 diabetes.12118251
Hyperlipidemia, Cardiovascular DiseasesDeregulated Nutrient SensingHyperlipidemia and insulin resistance frequently develop after renal transplantation, contributing to cardiovascular disease.12118856
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingHypertriglyceridemia was considered to be due to either diabetic dyslipidemia and/or tamoxifen.12120888
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThe patients were characterized by a high frequency of obesity and/or glucose intolerance.12121348
DyslipidemiasDeregulated Nutrient SensingDiabetic dyslipidemia is characterized by high triglyceride levels; low high-density lipoprotein cholesterol levels; small, dense low-density lipoprotein particles; and high free fatty acid levels.12123399
DyslipidemiasDeregulated Nutrient SensingWe evaluated the efficacy and safety of once-daily extended-release (ER) niacin in patients with diabetic dyslipidemia.12123399
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow doses of ER niacin (1000 or 1500 mg/d) are a treatment option for dyslipidemia in patients with type 2 diabetes.12123399
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance was assessed by an oral glucose tolerance test and defined as impaired glucose tolerance or diabetes mellitus.12131253
Glucose Intolerance (disease)Deregulated Nutrient SensingThese findings suggest that common types of physical activity such as bicycling and gardening may contribute to the prevention of glucose intolerance in elderly men12131253
Proteinuria, Glucose Intolerance (disease)Deregulated Nutrient SensingPreexisting diabetic injury in the donor may increase the risk for proteinuria, compromised renal function, and posttransplant glucose intolerance.12134115
Hypertensive (finding)Deregulated Nutrient SensingCombination therapy of exercise and angiotensin-converting enzyme inhibitor markedly improves insulin sensitivities in hypertensive patients with insulin resistance.12135133
Hypertensive (finding)Deregulated Nutrient SensingThe present study investigated whether the combination of exercise (increased production of BK) and ACEI (delay in breakdown of BK) might further improve insulin sensitivity in hypertensive patients with insulin resistance (HOMA-R>1.8).12135133
Hypertensive (finding)Deregulated Nutrient SensingThe combination of walking and ACEI further lowered blood concentrations of insulin and HOMA-R, which suggests that this treatment is beneficial for hypertensive patients with insulin resistance.12135133
Fatty degeneration, Failure (biologic function)Deregulated Nutrient SensingWe propose that the relationship between leptin and steatosis reflects a pathogenic role of leptin in hepatic insulin resistance and/or a failure of the antisteatotic actions of leptin ("peripheral leptin resistance").12143049
Dyslipidemias, Ischemic stroke, atheroscleroticDeregulated Nutrient SensingProtruding atherosclerotic aortic plaques and dyslipidaemia: correlation to subtypes of ischaemic stroke.12143784
Dyslipidemias, Venous StrokeDeregulated Nutrient SensingSevere plaques in the proximal aorta together with dyslipidaemia are seen more frequently in patients with atherothrombotic stroke.12143784
diabeticDeregulated Nutrient SensingThe differences disappeared in the diabetic subjects, probably as a result of increased prevalence of insulin resistance in this group.12145220
Calcification of coronary artery, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCoronary artery calcification in type 2 diabetes and insulin resistance: the framingham offspring study.12145227
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingWe categorized glucose tolerance by type 2 diabetes therapy (diagnosed diabetes) or with an oral glucose tolerance test (OGTT) (IFG, IGT, and OGTT-detected diabetes) and insulin resistance as an elevated fasting insulin level, in subjects attending the fifth examination (1991-1995) of the Framingham Offspring Study.12145227
Diabetes MellitusDeregulated Nutrient SensingOf 325 subjects aged 31-73 years, 51% were men, 11.2% had IFG/IGT, and 9.9% had diabetes (2.8% with diagnosed diabetes); 14.5% had insulin resistance.12145227
AtherosclerosisDeregulated Nutrient SensingIn age- and sex-adjusted models, subjects with insulin resistance were more likely to have subclinical atherosclerosis than those without insulin resistance (2.1, 1.01-4.2), but further risk factor adjustment weakened this association.12145227
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results suggest the LMNA 1908C/T single nucleotide polymorphism (SNP) is not associated with the prevalence of type 2 diabetes, although it may be a factor predisposing to insulin resistance and dyslipidemia in some Japanese.12145775
Dyslipidemias, Atherosclerosis, Obesity, Coronary heart diseaseDeregulated Nutrient SensingObesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease.12145779
Dyslipidemias, ObesityDeregulated Nutrient SensingElevated plasma apoC-III concentration is also a feature of dyslipidemia in obesity that contributes to the kinetic defects in apoB metabolism.12145779
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results show that a family history of Type 2 diabetes is an independent contributor of CRP concentrations, in addition to age, total fatness, central fat accumulation, and insulin resistance.12147152
Glucose Intolerance (disease), Insulin insensitivityDeregulated Nutrient SensingSubjects with poorer glucoregulation showed higher evoked glucose and insulin, suggestive of a mild glucose intolerance accompanied by mild insulin insensitivity.12148936
Peripheral Vascular DiseasesDeregulated Nutrient SensingCompared with controls, men with peripheral vascular disease had adverse metabolic profiles (relative insulin resistance and greater total cholesterol levels).12149100
AcromegalyDeregulated Nutrient SensingNo correlation was observed in acromegalic patients, although those with severe insulin resistance showed the lowest ghrelin values (161+/-20 pmol/l).12153739
OverweightDeregulated Nutrient SensingDecreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent.12160192
Hypertensive (finding), HyperuricemiaDeregulated Nutrient SensingHyperuricemia and hyperinsulinemia/insulin resistance are commonly seen in obese subjects and hypertensive patients.12160192
Overweight, HyperuricemiaDeregulated Nutrient SensingTo clarify whether the insulin resistance plays a role in hyperuricemia, we investigated alterations in serum uric acid (UA) concentrations during treatment with a low-energy diet or an insulin-sensitizing agent in overweight hypertensive patients.12160192
OverweightDeregulated Nutrient SensingThe amelioration of insulin resistance by either a low-energy diet or troglitazone decreased the serum UA level in overweight hypertensive patients.12160192
Increased insulin levelDeregulated Nutrient SensingInsulin resistance or hyperinsulinemia, independent of body weight and BP, may play an important role in UA metabolism in multiple risk factor syndrome.12160192
Dyslipidemias, Diabetes Mellitus, Congestive heart failureDeregulated Nutrient SensingIn summary, we demonstrated that the major cardiovascular risk factors age, diabetes, CHF, smoking, and dyslipidemia are important prognostic factors in the years after nonfatal MI.12160913
Weight Gain, ObesityDeregulated Nutrient SensingInsulin resistance is a known sequela of obesity; however, the relationship of insulin resistance to future weight gain remains unclear.12161515
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingPure uric acid stone formers have a much higher incidence of either diabetes or glucose intolerance.12164880
Increased insulin level, Congestive heart failureDeregulated Nutrient SensingCongestive heart failure (CHF) has previously been shown to be associated with insulin resistance and hyperinsulinemia.12167382
cell injuryDeregulated Nutrient SensingAlthough we are only beginning to understand the molecular mechanisms that mediate life span extension, the similarities between longevity regulatory pathways in organisms ranging from yeast to mice suggest that insulin/ IGF-1 signaling pathways may also regulate cell damage and longevity in humans.12169020
DyslipidemiasDeregulated Nutrient SensingFibric acid derivatives and HMG-CoA reductase inhibitors are effective in combination for treating patients with familial dysbetalipoproteinaemia and severe combined dyslipidaemia, but combination therapy affects compliance and increases the risk of side effects.12181212
TG gene, DyslipidemiasDeregulated Nutrient SensingHDL-C levels in patients with type IIa, IIb, or IV dyslipidemia were increased by a respective 10.9% (P < 0.001), 16.1% (P < 0.001), and 12.1% (P < 0.05), whereas TG levels were decreased by a respective 27.7% (P < 0.001), 46.4% (P < 0.001), and 40.2% (P < 0.05).12182255
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingIn the study population with moderate dyslipidemia (types IIa and IIb), it promoted beneficial changes in major lipid risk factors for cardiovascular disease.12182255
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe p85alpha subunit of phosphatidyl inositol 3 kinase (PIK3R1) and the regulatory subunit 3 of protein phosphatase 1 (PPP1R3) were selected as candidate genes because both encode key proteins involved in insulin signalling and because polymorphisms in these genes have been previously implicated in insulin resistance or type II diabetes.12185156
Data types - AddressDeregulated Nutrient SensingThe results support the hypothesis for a common genetic aetiology predisposing to insulin resistance and AD.12185156
Behavior, Cardiovascular DiseasesDeregulated Nutrient SensingThe association between physical activity, dietary behaviors, and elevated cardiovascular disease risk factor components of the insulin resistance syndrome in adults with mental retardation was identified.12186577
Increased insulin level, Obesity, AbdominalDeregulated Nutrient SensingThose who participated in more frequent bouts of physical activity or who consumed lower dietary fat intakes were approximately one third as likely to have hyperinsulinemia and abdominal obesity compared to those who participated in less frequent physical activity or who consumed higher fat intakes, suggesting that these behaviors are protective against elevated components of the insulin resistance syndrome.12186577
Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to investigate the associations between components of adult height (leg length, trunk length, ratio of leg to trunk length) and Type II (non-insulin-dependent) diabetes mellitus and insulin resistance.12189439
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results suggest that poor infant nutrition is an important causal factor in the development of Type II diabetes and insulin resistance in later life.12189439
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOne patient had type 2 diabetes treated by diet alone and one had a history of glucose intolerance.12190177
Hyperproinsulinemia, Hyperleucinemia, Cardiovascular DiseasesDeregulated Nutrient SensingHyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases.12190889
Coronary Artery DiseaseDeregulated Nutrient Sensing[Potential role of leptin and insulin resistance assessed by the glucose clamp technique in coronary artery disease].12194643
Coronary Artery DiseaseDeregulated Nutrient SensingLeptin may correlate with insulin resistance and be an important factor in patients with coronary artery disease.12194643
Coronary Artery DiseaseDeregulated Nutrient SensingTherefore, we examined whether plasma leptin levels and insulin resistance are linked with coronary artery disease.12194643
Coronary Artery DiseaseDeregulated Nutrient SensingPlasma leptin levels are correlated with insulin resistance and may be associated with coronary artery disease.12194643
LipodystrophyDeregulated Nutrient SensingA CLA-induced insulin resistance has previously been described only in lipodystrophic mice.12196420
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of total glucose intolerance (diabetes mellitus + impaired glucose tolerance) was 18.4%.12197326
Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease), square decimeterDeregulated Nutrient SensingTo know the prevalence of type 2 diabetes mellitus (DM2) and glucose intolerance (GIT) in the adult population in Asturias.12199991
Dyslipidemias, diabeticDeregulated Nutrient SensingThese data indicate that in diabetic patients, extended-release niacin (1) is effective for separately treating diabetic dyslipidemias associated with abnormal LDL size, HDL-2, and Lp(a) independently of glycated hemoglobin levels; (2) must be used with modern and aggressive oral hypoglycemic agents or insulin treatment; and (3) is a major drug for the treatment of diabetic dyslipidemias because of its broad spectrum of effectiveness for the ALP and Lp(a).12200755
Somatotropin deficiencyDeregulated Nutrient SensingOur results suggest that short-term administration of the highest GH dose induced insulin resistance, whereas the lowest dose (0.0017 mg/kg/day) could represent the optimal starting dose in GHD adults due to its beneficial effects on beta-cell function without compromising SI.12201825
Dyslipidemias, Coronary heart disease, Diabetes Mellitus, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAEDeregulated Nutrient SensingThe increased prevalence of coronary heart disease (CHD) in UK resident Indo-Asians is unexplained by the traditional cardiovascular risk factors of dyslipidaemia, hypertension, smoking and diabetes mellitus.12202835
Glucagonoma, Glucose Intolerance (disease), Jaundice, ObstructiveDeregulated Nutrient SensingOne patient (glucagonoma) presented with obstructive jaundice and mild glucose intolerance.12206598
Cerebrovascular DisordersDeregulated Nutrient Sensing[Relationship between insulin resistance and clustering of risk factors of cerebrovascular disease].12212210
Cerebrovascular DisordersDeregulated Nutrient SensingTo study the relationship between insulin resistance and clustering of risk factors of cerebrovascular disease.12212210
Cerebrovascular DisordersDeregulated Nutrient SensingInsulin resistance is associated with clustering of risk factors of cerebrovascular disease, the more resistant, the more clustered.12212210
OverweightDeregulated Nutrient SensingThe association between overweight, high blood pressure (BP), and insulin resistance is well established, but the role of body fat distribution in this association has yet to be fully elucidated.12219872
OverweightDeregulated Nutrient SensingThe aim of this study was to investigate the role of central adiposity in the association between overweight, high BP, and insulin resistance.12219872
Obesity, Coronary heart diseaseDeregulated Nutrient SensingRelationship between obesity, insulin resistance, and coronary heart disease risk.12225719
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingObesity and insulin resistance are both powerful predictors of CHD risk, and insulin resistance at any given degree of obesity accentuates the risk of CHD and type 2 diabetes.12225719
ObesityDeregulated Nutrient SensingMale gender, central obesity, elevated fasting glucose, and insulin resistance were associated with less favorable lipid levels.12226139
Weight decreased, DyslipidemiasDeregulated Nutrient SensingTo characterize dyslipidemia before and after weight loss in the severely obese.12226139
Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidemia of obesity is related to weight distribution, insulin sensitivity, and impaired glucose tolerance.12226139
Deficit, Diabetes MellitusDeregulated Nutrient SensingType 2 Diabetes is characterized by a deficit in early insulin secretion and increased insulin resistance.12235731
DyslipidemiasDeregulated Nutrient SensingPatients undergoing cardiac transplantation are at increased risk of dyslipidemia (60% to 80%).12236939
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was also present in at least half of both types of patients.12240795
LipodystrophyDeregulated Nutrient SensingClinical, endocrine and metabolic studies in the kindred of familial partial lipodystrophy--a syndrome of insulin resistance.12240840
LMNA wt AlleleDeregulated Nutrient SensingThe majority (2/3rd) of female members showed typical phenotypic features of FPLD, with a clustering of cardiovascular risk factors and insulin resistance syndrome.12240840
LMNA wt Allele, Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingMore than half the men without phenotypic features of FPLD had either IGT/DM, dyslipidemia, hypertension or cardiovascular disease.12240840
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingSubclinical hypothyroidism was associated with a high prevalence of dyslipidemia and a high prevalence of CAD.12242320
Biliary calculi, Cardiovascular Diseases, Dyslipidemias, Respiratory problem, Degenerative polyarthritis, Malignant Neoplasms, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity increases the risk for type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, respiratory problems, certain cancers, gallstones, osteoarthritis, and lowered life expectancy.12269468
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingThe prevalence of DM significantly increased in subjects by increases in blood pressure, and triglyceride and the relative risk in the prevalence of DM was significantly high with dyslipidemia (Odds ratio 2.29, 95% CI: 1.16-3.49).12298429
Diabetes Mellitus, Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingType 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), at least in the majority of patients characterized by insulin resistance and increased visceral fat, appears to be precipitated by the exposure of tissues to excessive levels of free fatty acids; this can contribute to the muscle insulin resistance, excessive hepatic gluconeogenesis, and beta cell dysfunction that collaborate to impair glycemic control.12323111
HyperglycemiaDeregulated Nutrient SensingThe resultant hyperglycemia, in turn, exacerbates the insulin resistance and beta cells dysfunction.12323111
Prediabetes syndrome, HaitiDeregulated Nutrient SensingA new strategy for achieving rapid loss of body fat - hepatothermic therapy (HT), an integrated approach involving exercise training, low-fat, low-glycemic-index food choices, and a supplementation program that promotes hepatic fatty acid oxidation - shows promise for alleviating the excessive fat exposure at the root of the diabetic syndrome, as well as the underlying insulin resistance syndrome responsible for increased macrovascular risk.12323111
Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIndependent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance.12351442
Hyperglycemia, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingClustering of classical cardiovascular risk factors is insufficient to account for the excess coronary artery disease (CAD) of patients with diabetes, and chronic hyperglycemia and insulin resistance (IR) are obvious culprits.12351442
Muscle (organ)Deregulated Nutrient SensingInsulin resistance is frequently associated with increased lipid content in muscle and liver.12351443
diabetic, Muscle (organ)Deregulated Nutrient SensingIn conclusion, these results indicate that IMCLs relate to insulin resistance in type 2 diabetic patients at baseline and that insulin-mediated near-normoglycemia for approximately 3 days reduces fasting glucose production but stimulates lipid accumulation in liver and muscle without affecting insulin sensitivity.12351443
AtherosclerosisDeregulated Nutrient SensingRisk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities study.12351449
AtherosclerosisDeregulated Nutrient SensingThe extent to which groupings of insulin resistance-related cardiovascular risk factors synergize to produce atherosclerosis beyond what is expected from their additive effects is uncertain.12351449
DyslipidemiasDeregulated Nutrient SensingOxLDL increase may explain the high atherogenic potency of dyslipidemia in the prediabetic state.12351454
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOur results show that postmenopausal women with diabetes had increased dyslipidemia compared with nondiabetic women.12351460
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingThe increased risk of coronary heart disease associated with type 2 diabetes may be partially explained by dyslipidemia characterized by high plasma triacylglycerol (TAG), low HDL cholesterol, and a predominance of atherogenic small dense LDLs.12351465
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFish oil supplementation may partially correct the dyslipidemia of type 2 diabetic patients.12351465
diabeticDeregulated Nutrient SensingHowever, the putative very important aspect of diabetic dyslipidemia-the predominance of small dense LDL particles-was unaffected by fish oil.12351465
diabeticDeregulated Nutrient SensingElevated CRP in diabetic women might reflect a particular sensitivity to insulin levels or might reflect insulin resistance.12351483
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingSyndrome X (clustering of insulin resistance, dyslipidaemia and hypertension) in adults with central obesity has been suggested to be a consequence of poor foetal development.12355325
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia is considered to be indicative of insulin resistance.12357293
diabeticDeregulated Nutrient SensingWe aimed at elucidating the interrelations between leptin, insulin and insulin resistance in type 2 diabetic patients.12357293
Autonomic nervous systemDeregulated Nutrient SensingFurthermore, heart rate recovery after exercise was related to several of the major components of the insulin resistance syndrome, thereby establishing a link between this syndrome and cardiac autonomic nervous activity.12360163
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most common CVR factors were dyslipidemia (59.5%), smoking (19%) and diabetes (16%).12365077
Hypertensive disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNearly two patients out of three presented at least one other major cardiovascular risk factor in addition to HBP (cigarette smoking, diabetes mellitus or dyslipidemia): 63.9% in 1999 and 64.4% in 2000.12365081
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe present study implies that younger women with CAD may have a higher prevalence of dyslipidemia, diabetes and smoking.12368928
Diabetes MellitusDeregulated Nutrient SensingTo asses whether clinically severe insulin resistance and poor metabolic control in patients with type 11 diabetes are associated with aberrant expression or function of the p21ras pathway.12369726
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTaken together, these data indicate that clinically significant severe insulin resistance does not modify the expression, regulation and activation of p21ras pathway in PBMC of patients with type II diabetes.12369726
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingSupplementation with t10c12 CLA markedly increased 8-iso-PGF(2alpha) (578%) and C-reactive protein (110%) compared with placebo (P<0.0001 and P<0.01, respectively) and independent of changes in hyperglycemia or dyslipidemia.12370214
Type 2Deregulated Nutrient SensingThe insulin resistance syndrome among type II diabetics.12370709
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingRelationships of the systolic blood pressure response during exercise with insulin resistance, obesity, and endurance fitness in men with type 2 diabetes mellitus.12370842
Demographics DomainDeregulated Nutrient SensingBased on these results, insulin resistance was suggested to be independently associated with the resting DBP and SBP response to standardized exercise intensity in type 2 DM patients.12370842
Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingPeritoneally dialyzed subjects (CAPD) are prone to dyslipidemia and have a high risk of cardiovascular death.12371384
Hypertensive (finding)Deregulated Nutrient SensingCarotid hemodynamic alterations in hypertensive patients with insulin resistance.12372671
AtherosclerosisDeregulated Nutrient SensingInsulin resistance (IR) is implicated in the pathogenesis of atherosclerosis.12372671
Dyslipidemias, Kidney FailureDeregulated Nutrient SensingFenofibrate is a potent hypolipemic agent, widely used in patients with renal insufficiency in whom dyslipidemia is frequent.12372935
Increased insulin level, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance and hyperinsulinemia has been reported in patients with chronic renal failure.12372963
Obesity, diabeticDeregulated Nutrient SensingImpact of Prol2Ala variant in the peroxisome proliferator-activated receptor (PPAR) gamma2 on obesity and insulin resistance in Japanese Type 2 diabetic and healthy subjects.12375694
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingWe examined the roles of the Pro12Ala variant of PPAR gamma2 in obesity and insulin resistance in 402 Japanese patients with type 2 diabetes and 116 control subjects.12375694
diabeticDeregulated Nutrient SensingThese data suggest that the Pro12Ala polymorphism of PPAR gamma2 does not influence insulin resistance but body composition in Japanese diabetic subjects.12375694
HyperglycemiaDeregulated Nutrient SensingThese data demonstrate that overexpression of hIGFBP-3 results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance.12376320
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and other cardiovascular disease risk factors.12376440
Dyslipidemias, ObesityDeregulated Nutrient SensingBelonging to manual social classes in childhood and in adulthood was independently associated with increased insulin resistance, dyslipidaemia, and general obesity.12376440
Dyslipidemias, ObesityDeregulated Nutrient SensingWomen who were in manual social classes in childhood remained at increased risk of insulin resistance, dyslipidaemia, and obesity--even if they moved into non-manual social classes in adulthood--compared with women who were in non-manual social classes at both stages.12376440
Obesity, Abdominal, Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingPrevalence rates of overweight,obesity, central obesity and dyslipidaemia.12380877
TG gene, DyslipidemiasDeregulated Nutrient SensingCompared to lean subjects, obese men and women had significantly higher mean serum TC, TG, LDL-C and a higher prevalence of dyslipidaemia.12380877
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPatient characteristics were comparable on recruitment excluding family history of cardiovascular disease (P=0.003), dyslipidaemia (P=0.004) and previous history of MI (P=0.007).12383139
Aortic arch calcification, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingIn simple regression analysis the gravity of aortic arch calcification was positively correlated with age (p=0.01), diabetes mellitus (p=0.014), hypertension (p=0.022), dyslipidemia (p=0.038) and coronary artery disease (p=0.041).12384643
Aortic arch calcification, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingGravity of aortic arch calcification in adult Greek patients may easily be assessed on routine chest X-rays and is positively correlated with coronary artery disease, as well as important cardiovascular risk factors (age, diabetes mellitus, hypertension and dyslipidemia).12384643
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship.12393073
Hypertension, CTCAEDeregulated Nutrient SensingOur findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese.12393073
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is closely related to developing type 2 diabetes mellitus.12402978
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe investigated the interactions among visceral fat accumulation, FFA metabolism and insulin resistance in 20 patients with type 2 diabetes mellitus, including 11 obese and 9 non-obese subjects.12402978
SR 202, HypertrophyDeregulated Nutrient SensingIn vivo, decreasing PPARgamma activity, either by treatment with SR-202 or by invalidation of one allele of the PPARgamma gene, leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance.12403851
TG geneDeregulated Nutrient SensingInsulin resistance is often accompanied by elevated plasma triglycerides (TG) and a preponderance of small, dense low-density lipoprotein (LDL) particles.12404201
TG geneDeregulated Nutrient SensingHowever, it remains unclear whether or not insulin resistance is related to LDL particle size, independent of plasma TG.12404201
Dyslipidemias, ObesityDeregulated Nutrient SensingPeroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia.12406034
Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingThese symptoms and signs include risk factors for cardiovascular disease such as hypertension, phenotype IV lipoproteinemia, insulin resistance, cardiac and vascular dysfunction, and morbidity in cardiovascular diseases.12412780
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNeither homeostasis model assessment nor quantitative insulin sensitivity check index can predict insulin resistance in elderly patients with poorly controlled type 2 diabetes mellitus.12414910
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, neither HOMA IR nor QUICKI should be used as an index of insulin resistance in elderly patients with poorly controlled type 2 diabetes mellitus.12414910
Hyperglycemia, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingHyperglycemia, dyslipidemia, and hypertension were evaluated as obesity-related complications.12419927
Tumor necrosisDeregulated Nutrient SensingThe cytokine tumour necrosis factor-alpha (TNF-alpha) is involved in the development of obesity-linked insulin resistance.12421433
Diabetes MellitusDeregulated Nutrient SensingOur data in a large and modern day pHPT series, with a preponderance of asymptomatic patients, confirm increased insulin resistance and pre-valence of IGT and undiagnosed diabetes.12421435
AcromegalyDeregulated Nutrient SensingGrowth hormone receptor antagonist improves insulin resistance in acromegaly.12423627
SialorrheaDeregulated Nutrient SensingGrowth hormone hypersecretion is a known cause of insulin resistance.12423627
Weight decreased, AcromegalyDeregulated Nutrient SensingThe results show that the Pegvisomant is an effective agent for improving insulin resistance in subjects who have acromegaly and that this effect is independent of weight loss.12423627
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no relation between ischemic ETT and other major cardiac risk factors (hypertension, dyslipidemia, smoking, sex, duration of diabetes, BMI, and glycated hemoglobin levels).12424409
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiabetes or glucose intolerance occurred in 18 GH-treated men vs 7 not receiving GH (P =.006).12425705
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingBecause adverse effects were frequent (importantly, diabetes and glucose intolerance), GH interventions in the elderly should be confined to controlled studies.12425705
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingBecause mortality rate after MI has been previously shown to be increased in diabetic patients, screening for glucose intolerance appears to be as essential as for standard cardiovascular risk factors.12426825
diabeticDeregulated Nutrient SensingThe (-)786T-C mutation of the eNOS gene is associated with insulin resistance in both Japanese non-diabetic subjects and Type II diabetic patients.12436344
Diabetes MellitusDeregulated Nutrient SensingApolipoprotein E kinetics: influence of insulin resistance and type 2 diabetes.12439646
Obesity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance related to obesity and diabetes is characterized by an increase in plasma TG-rich lipoprotein concentrations.12439646
ObesityDeregulated Nutrient SensingWhereas obesity did not influence apoE kinetic parameters in itself, insulin resistance may lead to an increase in VLDL apoE production and fractional catabolic rates.12439646
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone has been shown to be effective and well tolerated in the treatment of patients with type 2 diabetes, as it reduces insulin resistance and improves glycaemic control and abnormal lipid profiles.12439788
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSubjects with smoking habit, dyslipidemia, and diabetes mellitus were excluded from the study.12441213
Hyperlipidemia, Glucose Intolerance (disease)Deregulated Nutrient SensingClinical lipoatrophy in HIV-1 patients on HAART is not associated with increased abdominal girth, hyperlipidaemia or glucose intolerance.12444941
Hyperlipidemia, Glucose Intolerance (disease), LipoatrophyDeregulated Nutrient SensingLipoatrophic patients on HAART with neither increase in abdominal circumference, nor hyperlipidaemia nor glucose intolerance may have side-effects to protease inhibitor treatment, to nucleoside reverse transcriptase inhibitor treatment (stavudine) or suffer from a drug-independent condition.12444941
Dyslipidemias, Diabetes Mellitus, Sleep Apnea, CTCAE, Depression, CTCAE, Asthma, Acid refluxDeregulated Nutrient SensingMajor improvements have occurred in diabetes, asthma, gastroesophageal reflux, dyslipidemia, sleep apnea and depression.12448387
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia (high triacylglycerols and low HDL cholesterol) was more prevalent among Hispanics with than without diabetes.12450885
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHispanics with diabetes were at higher risk of dyslipidemia than were those without diabetes.12450885
Insulin Secretion, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVariants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians.12453914
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.12453914
Increased insulin levelDeregulated Nutrient SensingHowever, both a low prepregnancy maternal BMI and older maternal age at delivery were associated with hyperinsulinemia and evidence of insulin resistance in the offspring.12453959
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThere is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults.12453959
GDC Comorbidity Terminology, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingComorbid conditions of hypertension and dyslipidemia were not as well managed.12453965
GDC Comorbidity Terminology, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe comorbid conditions of hypertension and dyslipidemia are not optimally managed according to the ADA guidelines.12453965
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingDiabetes mellitus, impaired fasting glucose level, or insulin resistance are associated with increased risk of cardiovascular disease.12456232
Cataract, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingObesity increases the risk of developing cataract overall, and of PSC cataract in particular; the etiology of PSC cataract may be mediated at least in part by glucose intolerance and insulin resistance, even in the absence of clinical diabetes.12461675
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, ObesityDeregulated Nutrient SensingHypertension, dyslipidemia and type 2 diabetes, important cardiovascular risk factors, are strongly linked to obesity.12464375
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe lowest values of the areas were noted in detecting women with dyslipidemia and the highest in detecting those with type 2 diabetes.12464375
Critical IllnessDeregulated Nutrient SensingThese data suggest that hepatic insulin resistance in prolonged critically ill patients, reflected by high serum IGFBP-1 levels, is not overcome by intensive insulin therapy, and that this may affect patient outcome.12466347
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Postprandial hyperlactemiaDeregulated Nutrient SensingPostprandial hyperlipemia and small, dense LDL particles are features of dyslipidemia in type 2 diabetes.12469362
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is characterized by beta cell dysfunction and insulin resistance (IR).12477148
Impaired T cell functionDeregulated Nutrient SensingWe found that both IFG and DM were associated with beta cell dysfunction, insulin resistance, and elevated serum triglycerides.12477148
IFNG wt Allele, Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe conclude that the Ghanaian patients with IFG and type 2 diabetes were non-obese and exhibited severe beta cell dysfunction, insulin resistance, and elevated triglycerides, but none of the other conventional risk factors, at the time of diagnosis.12477148
Glucose Intolerance (disease)Deregulated Nutrient SensingHowever, the well established cardiovascular risk factors, such as body mass index, body fat distribution, and blood pressure did not track with the increasing glucose intolerance in the native Ghanaians.12477148
Hypercholesterolemia, CD55 gene, DyslipidemiasDeregulated Nutrient SensingTo determine the percentage of hypercholesterolemic patients who had met the criteria as total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), defined by the Chinese National Recommendations for Prevention and Treatment of Dyslipidemia.12482372
DyslipidemiasDeregulated Nutrient SensingData from this study indicated that a significant gap still existed between dyslipidemia prevention principles and clinical practices, suggesting that more aggressive treatment of dyslipidemia is needed.12482372
AtherosclerosisDeregulated Nutrient SensingTo illustrate the impact of westernization of lifestyle on the development of pre-clinical atherosclerosis in Japanese people, we compared risk factors for atherosclerosis such as serum lipids, blood pressure, BMI, insulin resistance, and smoking habits between non-diabetic native Japanese and non-diabetic Japanese Americans.12482552
Dyslipidemias, Kidney FailureDeregulated Nutrient SensingAtorvastatin and the dyslipidemia of early renal failure.12482566
Electrocardiogram: myocardial infarction (finding), AtherosclerosisDeregulated Nutrient SensingSince insulin resistance represents an important risk factor for atherosclerotic vascular disease and myocardial infarction, we investigated the involvement of the PC-1 K121Q polymorphism in the development of myocardial infarction.12483464
DyslipidemiasDeregulated Nutrient SensingLDL phenotype B is a component of diabetic dyslipidaemia, but its diagnosis is cumbersome.12486496
Dyslipidemias, Hyperinsulinism, Illness (finding), Obesity, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingThis report confirms findings in previous studies that fast-growing BPH is a risk factor for NIDDM, hypertension, tallness, obesity, dyslipidaemia and hyperinsulinaemia.12487736
ovarian neoplasmDeregulated Nutrient SensingThis study supports the hypothesis of a direct association between GI and GL and ovarian cancer risk and, consequently, of a possible role of hyperinsulinemia/insulin resistance in ovarian cancer development.12488297
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe aims were to estimate the prevalence of glucose intolerance and 7-yr incidence of Type II (non-insulin-dependent) diabetes mellitus in this population.12488952
diabeticDeregulated Nutrient SensingC-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients.12489071
diabeticDeregulated Nutrient SensingThese results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients.12489071
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingIn low and moderate risk patients (n=31) with borderline hypertension, dyslipidemia and pronounced obesity mainly non-drug measures were employed directed at lowering of excess body mass.12494181
Proteinuria, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn very high risk patients (n=79) with diabetes, excessive body mass, dyslipidemia and proteinuria complex therapy consisting of antihypertensive and hypoglycemic drugs and non-drug interventions was used.12494181
Cerebrovascular DisordersDeregulated Nutrient SensingLeptin may be an important link for the development of cerebrovascular disease in the insulin resistance syndrome in men.12499713
Hyperlipidemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMicronized fenofibrate may be considered an effective first-line therapy for patients with primary hyperlipidemia, particularly those with type IIb mixed dyslipidemia or type 2 diabetes.12500022
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe Pro12Ala polymorphism in the PPARgamma2 gene has been associated with reduced risk of type 2 diabetes and insulin resistance.12502512
Diabetes MellitusDeregulated Nutrient SensingWe demonstrated an association between the Ala allele and reduced risk of diabetes and insulin resistance in twins.12502512
ObesityDeregulated Nutrient SensingTo assess the independent associations of a broad range of early life risk factors and adult obesity with adult insulin resistance.12502664
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance is an important risk factor for type 2 diabetes and coronary heart disease.12502664
ObesityDeregulated Nutrient SensingThe degree of obesity did not relate to insulin resistance but was independently correlated with inflammatory proteins, uric acid, and systolic BP, variables that were often abnormal in this population.12502667
Obesity, Blood GlucoseDeregulated Nutrient SensingIn these grossly obese children, both insulin resistance and impaired insulin secretion contribute to the elevation of glycemia, and the degree of obesity is related to cardiovascular risk factors independently of insulin resistance.12502667
Dyslipidemias, Hyperlipoproteinemia Type IIIDeregulated Nutrient SensingPatients with dysbetalipoproteinaemia diagnosed by the presence of cholesterol-enriched very-low-density lipoproteins (VLDL) and/or dyslipidaemia associated with homozygosity for apolipoprotein E2 or carriers of the apoE2 (Arg145-->Cys) mutation.12506591
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingPatients with severe mixed hyperlipidaemia or clinical stigmata of dyslipidaemia should be assessed at a lipid clinic for a specific diagnosis and initiation of therapy.12506591
Prostate carcinomaDeregulated Nutrient SensingBecause high waist-to-hip ratio (WHR) and high serum insulin levels have been reported to be associated with an increased risk of prostate cancer, we assessed the relationship between insulin resistance and prostate cancer risk in Chinese men.12509402
Prostate carcinomaDeregulated Nutrient SensingRelative to men in the lowest tertiles, men in the highest tertile of insulin sensitivity had a reduced risk of prostate cancer (odds ratio [OR] = 0.35, 95% confidence interval [CI] = 0.21 to 0.60), but men in the highest tertile of insulin resistance had an increased risk of prostate cancer (OR = 2.78, 95% CI = 1.63 to 4.72).12509402
Prostate carcinomaDeregulated Nutrient SensingBecause of the retrospective design of this study, the role of insulin resistance in prostate cancer needs to be confirmed in prospective studies.12509402
square decimeter, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results suggest that in patients with DM2, the levels of fasting and absorptive FFA are significantly elevated, which is negatively correlated with the decline of ISI, implying the association of abnormal fasting and absorptive FFA and insulin resistance in patients with type 2 diabetes.12515147
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHowever, no differences were observed between the two groups as far as blood glucose control, arterial hypertension and dyslipidaemia were concerned.12518120
Demographics DomainDeregulated Nutrient SensingIn a prospective observational study, eight Type 2 DM patients with severe insulin resistance (insulin dose 1.92 +/- 0.66 U/kg per day (mean +/-sd)), in poor metabolic control (HbA(1c) 12.0 +/- 1.7%), were treated with i.v.12519325
Dyslipidemias, ObesityDeregulated Nutrient SensingIndices of obesity, dyslipidemia, and insulin resistance in apparently healthy Caribbean subjects.12526016
Dyslipidemias, Liver DysfunctionDeregulated Nutrient SensingLiver dysfunction in HNF-1alpha-null mice includes severe hepatic glycogen accumulation and dyslipidemia.12529398
Thrombus, Ischemic strokeDeregulated Nutrient SensingClustering of thrombotic factors with insulin resistance in South Asian patients with ischaemic stroke.12529744
Thrombus, Cerebrovascular accidentDeregulated Nutrient SensingWe aimed to investigate significant correlations of insulin resistance with thrombotic factors in South Asians with stroke.12529744
Thrombus, Ischemic stroke, Vascular DiseasesDeregulated Nutrient SensingThere is extensive clustering of metabolic and thrombotic factors with insulin resistance in South Asian patients with ischaemic stroke, which may contribute to high prevalence of vascular disease in this population.12529744
Cerebrovascular accidentDeregulated Nutrient SensingCoagulation factor VII activity, Arg/Gln353 polymorphism and features of insulin resistance in first-degree-relatives of South Asian patients with stroke.12529745
Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingCirculating levels of Factor VII:C are determined by R353Q genotype and cluster with other risk factors associated with insulin resistance in South Asian ischaemic stroke patients, first-degree relatives and control subjects but are not related to stroke or a family history of stroke.12529745
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes.12535753
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingEndothelial activation and acute-phase reaction correlate with insulin resistance and obesity in type 2 diabetic patients.12535753
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance and risk of chronic kidney disease in nondiabetic US adults.12538749
Chronic Kidney DiseasesDeregulated Nutrient SensingThe prevalence of CKD was significantly and progressively higher with increasing levels of serum insulin, C-peptide, HbA1c, and HOMA-insulin resistance.12538749
Increased insulin level, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThese findings combined with knowledge from previous studies suggest that the insulin resistance and concomitant hyperinsulinemia are presented in CKD patients without clinical diabetes.12538749
Chronic Kidney DiseasesDeregulated Nutrient SensingFurther studies into the causality between insulin resistance and CKD are warranted.12538749
Coronary Arteriosclerosis, Myocardial IschemiaDeregulated Nutrient SensingProspective studies have indicated that hyperinsulinaemia/insulin resistance is a risk factor for ischaemic heart disease (IHD), the risk decreasing with time of follow-up.12542553
diabeticDeregulated Nutrient SensingPlasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects.12547850
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe combined rates of glucose intolerance (diabetes, IGT, and IFG) were 32.3% (27.8-36.7%) for women and 49.8% (43.1-56.4%) for men (P < 0.0001).12547854
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes and glucose intolerance is extremely high among adult Arab Americans in Michigan and represents a major clinical and public health problem.12547854
DyslipidemiasDeregulated Nutrient SensingAtorvastatin treatment in diabetic dyslipidemia results in a significant dose-dependent decrease in HL activity, regardless of sex or the LIPC promoter variant.12547874
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingThese results show that the C242T mutation in the p22 phox gene is associated with progression of asymptomatic atherosclerosis in the subjects with type 2 diabetes and is also associated with insulin resistance in nondiabetic subjects.12547880
Glucose Intolerance (disease), ObesityDeregulated Nutrient Sensing1) Visceral obesity, more than age per se, correlates with glucose intolerance in middle-aged subjects; 2) aging does not influence in vitro adipose tissue glucose uptake.12547885
Traumatic injuryDeregulated Nutrient SensingInsulin resistance after surgery is caused by the surgical trauma and presumably also by other factors, such as starvation and immobilization.12553947
Dyslipidemias, ObesityDeregulated Nutrient SensingThese observations reinforce the importance of visceral obesity in the pathogenesis of dyslipidemia in men, and they suggest that visceral AT and liver fat carry independent health risk.12554597
Increased insulin level, Metabolic Diseases, Cardiovascular Diseases, Prostate Cancer Outcomes Study, Obesity, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is considered a metabolic disorder closely related to obesity, insulin resistance (IR), hyperinsulinemia and unfavorable lipid profile, all increasing the risk for the occurrence of cardiovascular diseases.12557616
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingInsulin treatment was started for his diabetes together with a special diet for dyslipidemia.12557965
Hypertriglyceridemia, Dyslipidemias, Coronary Artery Vasospasm, Angina Pectoris, VariantDeregulated Nutrient SensingWe conclude that patients with coronary spastic angina had smaller LDL particles, associated not with hypertriglyceridemia but low serum levels of both HDL-cholesterol and vitamin E. Dyslipidemia with small, dense LDL may be related to the genesis of coronary vasospasm.12559540
Hypertension, CTCAEDeregulated Nutrient SensingLeukocyte angiotensin II levels inpatients with essential hypertension:relation to insulin resistance.12559679
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingInsulin resistance is involved in the pathogenesis of type 2 diabetes, hypertension, and atherosclerosis.12559679
Hypertension, CTCAEDeregulated Nutrient SensingAngiotensin (Ang) converting enzyme inhibitors and Ang II type 1 receptor antagonists improve insulin resistance in patients with essential hypertension, which suggest that tissue Ang II is involved in insulin resistance in patients with hypertension.12559679
Dyslipidemias, Kidney Diseases, Cardiovascular AgentsDeregulated Nutrient SensingDyslipidemia frequently complicates chronic nephropathies and increases the risk of renal and cardiovascular events.12566371
Adolescent (age group), Prostate Cancer Outcomes Study, HIV, Lipodystrophy, Polycystic Ovary SyndromeDeregulated Nutrient SensingTo report a case of polycystic ovary syndrome (PCOS) in an adolescent infected with human immunodeficiency virus (HIV) and lipodystrophy whose insulin resistance was induced by highly active antiretroviral therapy (HAART).12568857
Lipodystrophy, Obesity, AbdominalDeregulated Nutrient SensingAfter 34 months of HAART this adolescent showed lipodystrophy with central obesity and insulin resistance after oral glucose tolerance test (OGTT).12568857
Lipodystrophy, Hirsutism, Amenorrhea, AcneDeregulated Nutrient SensingAfter 56 weeks of HAART, the adolescent showed more severe evidence of lipodystrophy and insulin resistance, and she developed acne, hirsutism, and amenorrhea.12568857
LipodystrophyDeregulated Nutrient SensingLipodystrophy and insulin resistance are well-recognized side effects of HAART.12568857
Lipodystrophy, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome might be an additional side effect secondary to insulin resistance and lipodystrophy.12568857
Metabolic Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingOn the other hand, 28% of the population was treated for known metabolic chronic diseases (CVD, diabetes, dyslipidemias and hypertension), whereas the remaining 33% of the Quebec population (BMI greater than 25 kg/m2) were characterized by an altered metabolic profile predictive of an increased CVD risk.12571695
Coronary heart diseaseDeregulated Nutrient Sensing[Relation between insulin resistance and A1166C molecular variant of type 1 angiotensin II receptor gene in patients with coronary heart disease].12575209
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingNo significant association between A1166C molecular variant of AT1R gene and insulin resistance was found in Chinese with CHD.12575209
Tumor necrosis, Cerebral HemorrhageDeregulated Nutrient Sensing[Effects of nao-yi-an on tumor necrosis factor alpha and insulin resistance of acute intracerebral hemorrhagic patients].12575232
Coronary heart diseaseDeregulated Nutrient Sensing[Preliminary study on relationship between TCM syndrome-type and insulin resistance in coronary heart disease].12575550
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo observe the relationship between TCM Syndrome-type and insulin resistance (ISR) in coronary heart disease (CHD).12575550
Hyperinsulinism, Liver CirrhosisDeregulated Nutrient SensingPatients with cirrhosis of the liver suffer from hyperinsulinaemia and a certain degree of insulin resistance.12577452
HyperinsulinismDeregulated Nutrient SensingDespite hyperinsulinaemia which persisted for one month after the operation, the insulin resistance did not deteriorate.12577452
Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and dyslipidaemia variables were closely related and loaded on the same factor.12581260
Blood coagulation, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient Sensing[Study on stroke syndrome of Chinese medicine and its relationship with blood hypercoagulative status and insulin resistance in diabetic ischemic stroke patients].12585102
Blood coagulation, Ischemic stroke, SyndromeDeregulated Nutrient SensingTo study the relationship of TCM Syndromes, involving Viscera Syndrome and involving Meridian Syndrome, with blood hypercoagulative state and insulin resistance in patients with diabetic ischemic stroke.12585102
Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingThere is close relationship between blood hypercoagulative state, insulin resistance and TCM Stroke Syndromes in patients with diabetic ischemic stroke.12585102
Coronary heart diseaseDeregulated Nutrient Sensing[Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease].12585165
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo explore the effect of puerarin in improving the insulin resistance (IR) and its closely related abnormal lipid and fibrinolytic activity in patients with coronary heart disease (CHD).12585165
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus was defined as glucose intolerance treated either dietary, with oral hypoglycemics or with insulin.12587082
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingOur data contradict previous findings suggesting an increased risk for insulin resistance, type II diabetes and atherosclerotic vascular disease in carriers of the mutation.12588284
ArteriosclerosisDeregulated Nutrient SensingAssociation between insulin resistance and carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance.12588774
Dental PlaqueDeregulated Nutrient SensingIn normal-type subjects, univariate analysis showed that insulin resistance, but not insulin secretion, was associated with the presence of carotid plaque.12588774
ArteriosclerosisDeregulated Nutrient SensingThese data suggest the possibility that the presence of higher insulin resistance could be a risk factor for carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance.12588774
Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance of the mothers was associated with an early middle-aged onset of diabetes, reduction in the insulin secretory capacity, early requirement of insulin therapy, and increases in the daily insulin dose.12590018
CardiomyopathiesDeregulated Nutrient SensingThis study suggests a direct link between insulin resistance and acromegalic cardiomyopathy.12590638
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose tolerance normalized in patients with preoperative glucose intolerance (n=7) or diabetes mellitus (n=3).12590638
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.12591951
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThese data demonstrate that low glucose disposal rates are robustly associated with the development of diabetes in the FH+ individuals, but insulin resistance per se is not sufficient for the development of diabetes in individuals without family history of disease and strongly suggest a familial factor, not detectable in our current measures of the dynamic responses of glucose or insulin to an IVGTT is an important risk factor for type 2 diabetes.12591951
Increased insulin levelDeregulated Nutrient SensingBesides hyperinsulinemia, they had insulin resistance and impaired carbohydrate tolerance.12592900
ObesityDeregulated Nutrient SensingAssociation of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare.12601637
ObesityDeregulated Nutrient SensingPAI-1 levels are associated with insulin resistance, irrespective of obesity.12601637
Metabolic DiseasesDeregulated Nutrient SensingThis associated metabolic disorder includes peripheral insulin resistance, which may be caused by factors produced by the PC.12604916
Glucose Intolerance (disease), Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance or overt diabetes occurs in 80% of patients with pancreatic cancer (PC).12604916
Hypertensive (finding)Deregulated Nutrient SensingThere is substantial but not conclusive evidence that insulin resistance is related to left ventricular mass (LVM) in hypertensive individuals.12608937
Insulin SecretionDeregulated Nutrient SensingThis study compared both categories with respect to the degree of insulin secretion abnormalities and insulin resistance.12610051
Deficit, teratologicDeregulated Nutrient SensingOur cross-sectional data from the RIAD study demonstrate that isolated IFG and isolated IGT are different with respect to the degree of insulin resistance and anomalies in insulin secretion, and that subjects with IGT exhibit a deficit in the early and late phases of insulin secretion.12610051
diabeticDeregulated Nutrient SensingWhether the adipocyte-derived protein adiponectin is associated with insulin resistance independently of the effects of adiposity and the diabetic state is an important question.12611616
Hypoadiponectinemia, AtherosclerosisDeregulated Nutrient SensingBecause adiponectin is thought to have an anti-atherogenic action, the presence of hypoadiponectinemia may predispose subjects to atherosclerosis, and may progress the atherogenesis in insulin resistance.12611616
Disturbance, DyslipidemiasDeregulated Nutrient SensingA large prevalence of body weight disturbances and high frequency of dyslipidemias are the main characteristics of this population.12616806
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension was found in 47% and dyslipidemia in 55%; 69% were smokers.12616807
AtherosclerosisDeregulated Nutrient SensingAssociations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis.12624279
AtherosclerosisDeregulated Nutrient SensingAlthough these findings suggest an association with insulin resistance and atherosclerosis, this hypothesis has yet been tested only partially.12624279
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSubjects with smoking habit, dyslipidaemia and diabetes mellitus were excluded from the study.12624606
Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingIn total, 907 participants, 537 hypertensive and 370 nonhypertensive, from 311 Taiwanese families were drawn from the Stanford Asia and Pacific Program for Hypertension and Insulin Resistance for the study.12624610
Cardiovascular DiseasesDeregulated Nutrient SensingLow birth weight has been linked to insulin resistance and cardiovascular disease.12629115
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings suggest that resistin may play a role in the pathogenesis of type 2 diabetes and insulin resistance-related hypertension.12629116
Proteinuria, Glucose Intolerance (disease), Glomerulosclerosis (disorder)Deregulated Nutrient SensingIn addition, glucose intolerance and proteinuria for men were found to be significant risk factors for glomerular sclerosis.12631368
Proteinuria, Glucose Intolerance (disease)Deregulated Nutrient SensingIn addition, glucose intolerance, total cholesterol, ECG abnormalities, and proteinuria affect either glomerular or vascular changes.12631368
Demographics Domain, Diabetes Mellitus, diabeticDeregulated Nutrient SensingMoreover, patients were further categorized into normal fasting glucose and glucose intolerance (diabetes mellitus (DM) and impaired fasting glucose) according to the diagnostic criteria of American Diabetic Association.12632506
Glucose Intolerance (disease), Hepatitis C, ChronicDeregulated Nutrient SensingIn conclusion, 34.6 % of Chinese patients with chronic hepatitis C had glucose intolerance.12632506
Glucose Intolerance (disease), Hepatitis C, Diabetes MellitusDeregulated Nutrient SensingChronic hepatitis C patients who were older in age, obese, had previous IFN treatment history and had family history of diabetes were prone to develop glucose intolerance.12632506
Polycystic Ovary Syndrome, Pituitary Adenoma, Disorder of endocrine ovaryDeregulated Nutrient SensingInhibition of growth hormone excess reduces insulin resistance and ovarian dysfunction in a lean case of polycystic ovary syndrome with a growth-hormone-producing pituitary adenoma.12637795
Obesity, Abdominal, AtherosclerosisDeregulated Nutrient SensingThe Trp64Arg variant of the beta3-adrenergic receptor gene is reported to be associated with abdominal obesity and resistance to insulin, and as a consequence, this variant may be a genetic factor in the development of atherosclerosis.12647276
Hyperglycemia, Hypertensive (finding), Dyslipidemias, Left Ventricular HypertrophyDeregulated Nutrient SensingHyperglycemia and/or dyslipidemia, even mild, seem to increase the risk of VA in the hypertensive patient with or without LVH.12652262
HyperglycemiaDeregulated Nutrient SensingBased on our study and published data, a putative pathogenic pathway was suggested: LPL enzyme deficiency causes elevated plasma triglyceride level and subsequent insulin resistance; both increased free fatty acids and insulin resistance promote gluconeogenesis and hyperglycaemia, a vicious circle leading to type 2 diabetes.12655575
Dyslipidemias, ObesityDeregulated Nutrient SensingIndependent of other factors, important contributors to obesity and dyslipidemia in this population were dietary factors such as meat (p < 0.001) and fish (p < 0.05), and a lower REE (p < 0.05).12656207
Dyslipidemias, ObesityDeregulated Nutrient SensingThese findings suggest that unhealthy diet and lower energy expenditure are important contributors to obesity and dyslipidemia in Tanzania.12656207
Glycogen Storage Disease Type V, ObesityDeregulated Nutrient Sensing[McArdle's disease with insulin resistance caused by obesity].12661110
Glycogen Storage Disease Type VDeregulated Nutrient SensingWe reported a 29-year-old woman with McArdle's disease accompanied with insulin resistance.12661110
ObesityDeregulated Nutrient SensingHer obesity might be a causative factor of insulin resistance.12661110
Uremia, HD Term Type, DyslipidemiasDeregulated Nutrient SensingMultiple logistic regression analysis showed that independent risk factors of AOL of cerebral arteries were uremic state, dyslipidemia, and age in all subjects and dyslipidemia and age in HD patients (R.2=0.162, p=0.0004; R.2 =0.138, p=0.0145, respectively).12662216
HD Term Type, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingOur findings suggest that chronic renal failure maintained by hemodialysis increases the prevalence of AOL, and that age and dyslipidemia are also significantly associated with AOL in HD patients.12662216
deficiency aspects, Diabetes MellitusDeregulated Nutrient SensingFurther study may address whether diabetes is causally associated with insulin deficiency or insulin resistance.12663569
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSubjects with IPH exhibited distinctly impaired early-phase insulin secretion and only mild insulin resistance, indicating that reduced insulin secretion is the primary determinant of deterioration from NGT to IGT and IPH in development of type 2 diabetes in these subjects.12663599
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDecreased synthesis of nitric oxide (NO) and dyslipidemia are implicated in the development of atherosclerosis.12666069
Hyperlipidemia, Myocardial Ischemia, Polycystic Ovary SyndromeDeregulated Nutrient SensingHomocysteine is a risk factor for ischemic heart disease; similarly as is hyperlipidemia or insulin resistance, which frequently occur in women with polycystic ovary syndrome.12667010
Polycystic Ovary SyndromeDeregulated Nutrient SensingWe conclude that homocysteine is increased in women with polycystic ovary syndrome and is probably linked to androgen levels but not to markers of insulin resistance or with lipid metabolism.12667010
DyslipidemiasDeregulated Nutrient SensingLp(a) levels vary in different dyslipidaemias according to the underlying disease.12668913
Diabetes MellitusDeregulated Nutrient SensingIn animals, acceleration of neonatal growth is thought to increase the later propensity to insulin resistance and non-insulin-dependent diabetes, whereas slow growth as a consequence of undernutrition is thought to have a beneficial effect.12672313
ObesityDeregulated Nutrient SensingThe Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men.12673785
Dyslipidemias, ObesityDeregulated Nutrient SensingThe Pro12Ala PPARgamma2 polymorphism has been variably associated with obesity, insulin sensitivity, and dyslipidemia.12673785
Glucose Intolerance (disease), Amenorrhea, Oligomenorrhea, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes and glucose intolerance were statistically significantly associated with amenorrhea and oligomenorrhea.12679164
methionineDeregulated Nutrient SensingIn obese, insulin-resistant patients with T2DM who are inadequately controlled on MET, the addition of an agent that reduces insulin resistance may be a more rational and innovative approach than the addition of an insulin secretagogue.12681023
DyslipidemiasDeregulated Nutrient SensingTwo lipid abnormalities--increased cholesterol and atherogenic dyslipidemia--are potential targets of lipid-lowering therapy.12686335
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingPatients with chronic renal failure commonly suffer from a secondary form of complex dyslipidaemia, and may benefit from lipid-lowering treatment.12686673
Cardiovascular DiseasesDeregulated Nutrient SensingRecently, serum GGT concentrations have been associated with many cardiovascular disease risk factors or components of the insulin resistance syndrome.12687334
Hypertension, CTCAE, Psychiatric, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThus, we find unethical do not treat hypertension, dyslipidemia and diabetes in severe psychiatric patients.12693284
Dyslipidemias, Chronic Kidney Diseases, Corneal Endothelial Cell LossDeregulated Nutrient SensingThe relationships between plasma ADPN, serum cholesterol, and serum albumin suggest that this adipocyte protein may serve to mitigate endothelial damage triggered by dyslipidemia and other risk factors in patients with chronic renal diseases.12694320
Malignant neoplasm of endometrium, NeoplasmsDeregulated Nutrient SensingTumor estrogen content in endometrial cancer has clinical significance that is modified in the presence of certain endocrine characteristics related to insulin resistance.12695909
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingIn light of the fact that the development of insulin resistance in adipocytes is responsible for the excessive free fatty acid flux that gives rise to the diabetic syndrome, a favorable impact of ACE inhibition on adipocyte insulin responsiveness - complemented by a potentiation of the direct action of bradykinin on skeletal muscle - offers a satisfying explanation for the prevention of diabetes observed during ACE inhibitor therapy.12699703
Diabetes MellitusDeregulated Nutrient SensingThe transition from IGT to diabetes was accompanied by a progressive deterioration of insulin reserve as well as insulin resistance.12701062
Glucose Intolerance (disease)Deregulated Nutrient SensingIn conclusion, both impaired insulin secretion and insulin resistance may contribute to the underlying mechanisms of glucose intolerance in Japanese subjects.12701062
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPresence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes.12706317
Increased insulin levelDeregulated Nutrient SensingInsulin resistance was estimated using HOMA(IR), basal hyperinsulinemia and I(0)/G(0) ratio.12706317
Alzheimers Disease", Dyslipidemias, Data types - AddressDeregulated Nutrient SensingThe statin treatment of dyslipidemia is associated with a reduced risk of development of Alzheimer disease (AD).12707064
Metabolic Diseases, Dyslipidemias, OverweightDeregulated Nutrient SensingMetabolic disorders were found in 97% of the non-steatosis patients (overweight: 40%, perturbed sugar metabolism: 47%, dyslipidemia: 79.5%).12712916
Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingThe prevalences were: overweight, 67.8%; obesity, 14.4%; central obesity, 72.2%; hypertension, 4.4%; dyslipidemia, 44.4%; hyperuricemia, 5.6%; GAD65 antibody positivity, 4.4%; smoking, 25.6%; chronic alcohol use, 0.0%.12713144
Non-insulin Hypoglycemic, Obesity, Abdominal, Premature coronary artery atherosclerosis, Dyslipidemias, Diabetes Mellitus, Coronary Artery DiseaseDeregulated Nutrient SensingSo the higher incidence of non-insulin dependent diabetes mellitus with central obesity suggesting insulin resistance along with unique profile of dyslipidemia, higher incidence of smoking and familial predisposition of premature coronary artery disease may be responsible for higher incidence of coronary artery disease at a premature younger age in this population.12715632
Autonomic nervous system disordersDeregulated Nutrient SensingThese findings suggest that marked autonomic dysfunction, rather than other confounding factors, is related to increased insulin resistance in DM.12716078
Hyperlipidemia, Glucose Intolerance (disease), Ventricular Fibrillation, Hypertension, CTCAEDeregulated Nutrient SensingVisceral-fat (VF) accumulation is suggested to be a major contributor to such cardiovascular-disease risk factors as hypertension (H), glucose intolerance (G), and hyperlipidemia (L).12716082
Wolff-Parkinson-White Syndrome, Autosome, Hypertrophic CardiomyopathyDeregulated Nutrient SensingMutations in the PRKAG2 gene that encodes the gamma2 regulatory subunit of AMP-activated protein kinase have been shown to cause autosomal dominant Wolff-Parkinson-White (WPW) syndrome associated with hypertrophic cardiomyopathy.12716108
LMNA wt Allele, Diabetes MellitusDeregulated Nutrient SensingPatients with FPLD are predisposed to metabolic complications of insulin resistance such as diabetes.12716787
Glucose Intolerance (disease)Deregulated Nutrient SensingWe found that glycemic status influenced LDL oxidizability, with a paradoxical reduction in LDL oxidizability, as indicated by a lower LDL oxidation rate with increased extent and duration of glucose intolerance.12716803
ObesityDeregulated Nutrient SensingTo estimate leptin production in long-term steroid therapy, insulin resistance and obesity.12718213
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingIdentification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans.12719377
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingRisk factors for coronary heart disease (CHD), including prethrombotic changes in hemostasis, cluster with the insulin resistance (IR) syndrome.12724002
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingPrevalence of hypertension was higher in subjects with glucose intolerance.12725257
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingAlthough young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging.12727934
Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Peripheral Vascular DiseasesDeregulated Nutrient SensingUtilization of lipid-lowering drugs in elderly persons with increased serum low-density lipoprotein cholesterol associated with coronary artery disease, symptomatic peripheral arterial disease, prior stroke, or diabetes mellitus before and after an educational program on dyslipidemia treatment.12730252
Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Peripheral Vascular DiseasesDeregulated Nutrient SensingWe report the prevalence of use of lipid-lowering drugs in elderly persons with increased serum low-density lipoprotein (LDL) cholesterol associated with coronary artery disease (CAD), symptomatic peripheral arterial disease (PAD), prior stroke, and diabetes mellitus before and after an educational program on the treatment of dyslipidemia.12730252
Dyslipidemias, Cerebrovascular accident, Diabetes MellitusDeregulated Nutrient SensingA 5-month educational program on dyslipidemia treatment given to physicians and nurse practitioners in an academic nursing home improved the prevalence of use of lipid-lowering drugs in persons with increased serum LDL cholesterol associated with CAD, symptomatic PAD, prior stroke, and diabetes mellitus.12730252
Dyslipidemias, PoliomyelitisDeregulated Nutrient SensingPolio patients have a high prevalence of dyslipidemia.12736884
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOf patients not at target levels, 14.4%, 27.5%, and 86.7% reported receiving no therapy for hyperglycemia, hypertension, and dyslipidemia, respectively.12741441
Glucose Intolerance (disease), Hepatitis C, Liver CirrhosisDeregulated Nutrient SensingTaken together, the findings indicate that cirrhosis appears to be a more important predictor of glucose intolerance than HCV infection, and the combination of both factors increases the risk of DM in our populations.12743775
ObesityDeregulated Nutrient SensingMutations in the peroxisome proliferator-activated receptor-gamma 2 (PPAR-gamma 2) gene may cause obesity and insulin resistance.12746759
SteatohepatitisDeregulated Nutrient SensingThe aim of study was to investigate whether or not insulin resistance exists in patients with steatohepatitis.12749246
SteatohepatitisDeregulated Nutrient SensingOur findings demonstrate that insulin resistance does exist in patients with steatohepatitis and the pathophysiological mechanisms causing resistance is not clear but insulin action is an issue of further investigation.12749246
Abnormality of mitochondrial metabolismDeregulated Nutrient SensingMitochondrial dysfunction in the elderly: possible role in insulin resistance.12750520
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly.12750520
Dyslipidemias, Diabetes Mellitus, Anemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingOther cardiovascular risk factors analyzed were arterial hypertension, diabetes mellitus, obesity, cigarette smoking, anemia, and dyslipidemia.12753281
Cancer-related fatigue, Diabetic Nephropathy, Dyslipidemias, diabetic, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAn increase of VLDL apo CIII is a prominent feature of dyslipidemia in CRF patients, regardless of whether they are diabetic or nondiabetic, whereas an increase of VLDL apo CI is more specific to diabetic nephropathy and is closely associated with an increase of VLDL particle numbers, a new risk factor for CHD.12753304
Muscle hypertrophyDeregulated Nutrient SensingVascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies.12756402
HypertrophyDeregulated Nutrient SensingIn conclusion, insulin resistance was not related to LV hypertrophy or reduced LV function.12756402
Hypertension, CTCAE, HereditaryDeregulated Nutrient Sensing[Is insulin resistance a common pathway for hereditary and environmental factors-induced hypertension?].12757656
Hypertension, CTCAE, HereditaryDeregulated Nutrient SensingInsulin resistance is a common route for hereditary and environmental factors to induce hypertension.12757656
Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient SensingHypertriglyceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance: evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes.12759893
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThis effect may partially be relevant to the clinical benefits of gemfibrozil in the treatment of dyslipidemia and atherosclerosis.12763281
Dyslipidemias, Atherosclerosis, diabeticDeregulated Nutrient SensingHence our patients are at increased risk of developing atherosclerosis therefore periodic check up of lipids in diabetic patients and effective treatment of the dyslipidemia along with a tight metabolic control was recommended.12764995
Breast Carcinoma, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes.12766105
DyslipidemiasDeregulated Nutrient SensingDyslipidemia may be a major contributor in this process and can be influenced by lipid-lowering drugs (statins).12768071
Xanthoma, DyslipidemiasDeregulated Nutrient SensingTherefore, in this patient, xanthoma of bone was the first sign of dyslipidemia.12771840
Alopecia, HeredityDeregulated Nutrient SensingHair loss, insulin resistance, and heredity in middle-aged women.12775957
Hypercholesterolemia, Coronary Artery Disease, Androgenetic AlopeciaDeregulated Nutrient SensingThe association of androgenic alopecia (AGA) with insulin resistance, coronary artery disease and hypercholesterolemia has been previously reported in men, but no such association has been reported in women with female androgenic alopecia (AGA).12775957
Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovarian syndrome is quite common among Caucasian women, and its association with insulin resistance is well documented.12775957
Hypertensive (finding), Albuminuria, Metabolic Syndrome XDeregulated Nutrient SensingAlbuminuria is independent of insulin resistance and other phenotypic components of the metabolic syndrome in never-treated, non-diabetic essential hypertensive men.12777954
Microalbuminuria, Antihypertensive AgentsDeregulated Nutrient SensingMicroalbuminuria is more frequent in obese hypertensives but this association is explained by higher blood pressure more than insulin resistance.12777954
Glucose Intolerance (disease), Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAlthough conventional risk factors such as glucose intolerance, hypertension, and dyslipidemia probably contribute, there may also be direct effects of GH/IGF-I excess on the vasculature.12788854
Obesity, Visceral, Prostate Cancer Outcomes Study, Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Endocrine System Diseases, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS), a common endocrine disorder of reproductive-aged women, is associated with multiple risk factors for coronary heart disease (CHD), such as diabetes mellitus, dyslipidemia, visceral obesity, and hypertension.12788855
ObesityDeregulated Nutrient SensingSeveral markers of chronic immune activation have been found in association with obesity and insulin resistance.12788878
Hypertensive (finding)Deregulated Nutrient SensingThere was no relation between SUA and insulin resistance in these hypertensive groups.12797630
DyslipidemiasDeregulated Nutrient SensingA systematic secondary preventive strategy may help achieve an adequate control of dyslipidemia in most CAD patients.12797928
Insulin resistance syndrome, Electrocardiogram: myocardial infarction (finding), Metabolic Syndrome X, ObesityDeregulated Nutrient SensingThat sex hormones, insulin, and obesity all correlate with the constellation of risk factors for myocardial infarction (MI) that has come to be known as "syndrome X," the "insulin-resistance syndrome," or the "metabolic syndrome" suggests that any one or more of them could underlie and link the risk factors to form the constellation.12800107
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBearing in mind that the main defects in type 2 diabetes mellitus are reduced FPIS and insulin resistance, and the favourable effect vitamin D3 had on them, we suggest vitamin D3 deficiency may at least partly contribute to the impairment of insulin secretion and probably of insulin action.12800453
Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance characterizes type 1 diabetes mellitus with nephropathy.12803834
diabeticDeregulated Nutrient SensingWe measured urinary excretion of PC-1 (alkaline phosphodiesterase I), a potential factor of insulin resistance, and N-acetyl-beta-D-glucosaminidase (NAGA) in 62 type 1 diabetic patients with different damage to the kidney.12803834
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a key feature of type 2 diabetes mellitus.12803833
Saint Helena Islands, Dyslipidemias, Myocardial Ischemia, HypothyroidismDeregulated Nutrient SensingThe increased risk for ischemic heart disease (IHD) associated with subclinical hypothyroidism (SH) has been partly attributed to dyslipidemia.12804105
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAll subjects had type 2 diabetes and a modest dyslipidaemia (mean LDL-cholesterol 3.2 mmol/l and median triglycerides 1.8 mmol/l) and had a previous myocardial infarction.12818407
TG gene, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingHigh apoCIII concentration in apoB lipoproteins is a prominent component of atherogenic dyslipidemia, and explains the risk of coronary heart disease (CHD) associated with high triglyceride (TG).12818412
TG gene, Dyslipidemias, diabeticDeregulated Nutrient SensingWe hypothesized that diabetic people have atherogenic dyslipidemia with apoCIII in excess of that accounted for by their high TG levels.12818412
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingSedentarism (87.2%), dyslipidemias (71.5%), high blood pressure (13.5%), obesity (13.1%), smoking (12.4%) and diabetes (2.8%) were the more prevalent RF.12818466
Hypertensive diseaseDeregulated Nutrient SensingThe insulin resistance index (HOMA-IR) in the HBP and the NBP groups were 2.49+/-0.2 and 1.95+/-0.13 (p<0.05).12819902
Hypertensive (finding), Hyperinsulinism, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingWe found clustering of hyperinsulinaemia, insulin resistance and truncal obesity in hypertensive Ghanaian subjects but dissociation between insulin resistance, hypertension and atherogenic lipid and lipoprotein profile.12819902
Coma (genus), Glucose Intolerance (disease), Diabetic KetoacidosisDeregulated Nutrient SensingSeverity of disease ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma.12820816
LipodystrophyDeregulated Nutrient SensingThese results suggest that adiponectin and the TNFalpha system are related to lipodystrophy, insulin resistance and metabolic alterations in patients under PI-based HAART.12824788
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingBoth women had atherosclerosis risk factors: current smoking, use of estrogen containing pill, dyslipidemia and/or familial cardiovascular history.12829221
Kidney DiseasesDeregulated Nutrient SensingIncreased resistin blood levels are not associated with insulin resistance in patients with renal disease.12830457
Kidney DiseasesDeregulated Nutrient SensingWe explored the potential role of resistin in the pathophysiological process of insulin resistance encountered in patients with renal disease.12830457
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitus.12837046
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this pilot, randomized, double-blind study, we compared the effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia and type 2 diabetes mellitus.12837046
HyperglycemiaDeregulated Nutrient SensingDelayed glucose clearance after hyperglycemia may contribute to insulin resistance.12840207
Hyperglycemia, PostprandialDeregulated Nutrient SensingIn conclusion, modest increases in abdominal adiposity and circulating lipids are associated with abnormal glucose clearance in clinically healthy older men; this may be a precursor to the development of insulin resistance and related complications that arise from prolonged postprandial hyperglycemia.12840207
Retinal Vein Occlusion, AtherosclerosisDeregulated Nutrient SensingInsulin resistance and atherosclerosis in branch retinal vein occlusion.12842202
Retinal Vein Occlusion, atheroscleroticDeregulated Nutrient SensingTo investigate insulin resistance and atherosclerotic change in patients with branch retinal vein occlusion (BRVO).12842202
DyslipidemiasDeregulated Nutrient SensingEfficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia.12843167
DyslipidemiasDeregulated Nutrient SensingThis fact forms a contrast with a high degree of dyslipidemia control.12848599
Inflammation, Dyslipidemias, Diabetes Mellitus, Obesity, No metabolic abnormalitiesDeregulated Nutrient SensingOn the other hand, several metabolic abnormalities such as dyslipidemia, hyperinsulinemia/insulin-resistance, diabetes, and obesity causes inflammation followed by a later rise in arterial BP.12850386
Carotid AtherosclerosisDeregulated Nutrient SensingIndeed, age (P <.001), insulin resistance syndrome score (P =.05), IL-1 beta (P <.05), and severity of carotid atherosclerosis (P <.05) were the only significant predictor of systolic BP.12850386
Disease, Diabetes MellitusDeregulated Nutrient SensingThe increased levels of insulin on an empty stomach and in 120-th minute of OGT test at an early stage of diabetes type 2 provide a good insight into insulin resistance disorders, whereas the values of the alfa index of stimulation (the level of insulin in the 60-th minute of OGT test/the level of insulin on an empty stomach) point to a disorder in insulin secretion.12858649
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, pediatric post-transplant diabetes may be related to reversible insulin resistance.12859535
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThus, pravastatin reduced potentially atherogenic remnant particles, a prominent component of diabetic dyslipidemia associated with coronary events; these results may contribute to its demonstrated effectiveness in reducing coronary heart disease in diabetics.12860210
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, AtherosclerosisDeregulated Nutrient SensingThe human adiponectin gene has been implicated in the pathophysiology of obesity, type II diabetes mellitus, dyslipidemia and atherosclerosis.12861229
Heart DiseasesDeregulated Nutrient SensingOur findings do not support the hypothesis that susceptibility to heart disease in South Asians results from a combination of high insulin resistance and high Lp(a) levels.12864778
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingSedentarism (87.2%), dyslipidemias (71.5%), high blood pressure (13.5%), obesity (13.1%), smoking (12.4%) and diabetes (2.8%) were the most prevalent RF.12870232
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Obesity, NEUROD1 wt AlleleDeregulated Nutrient SensingGlucose intolerance (GI) is preceded by a prolonged period of Insulin Resistance (IR) and is an advanced stage towards the development of Type 2 Diabetes Mellitus (NIDDM), whose incidence is increasing in the pediatric population, along with obesity.12870237
Diabetes Mellitus, Dyslipidemias, Overweight, AtherosclerosisDeregulated Nutrient SensingComplications of overweight, such as type-2 diabetes Mellitus, dyslipidemia and diffuse atheromatosis are common.12870238
Hyperplastic Polyp, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn patients with diabetes mellitus, dyslipidemia or more than two cardiovascular risk factors, vitamin C decreased endothelial and platelet-derived MP levels by approximately 70% and 13%, respectively.12871555
Cushing Syndrome, DyslipidemiasDeregulated Nutrient SensingThe dyslipidemia and elevation of lactate dehydrogenase activity in this series indicated the need for routine laboratory testing in Cushing's syndrome patients.12874666
Cardiovascular DiseasesDeregulated Nutrient SensingIn Europid populations, low birth weight of offspring predicts insulin resistance in the mother and cardiovascular disease in both parents.12882927
Malignant tumor of colon, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is an important risk factor for development of type 2 diabetes as well as other chronic conditions, including hypertension, cardiovascular disease, and colon cancer.12882937
AtherosclerosisDeregulated Nutrient SensingWe have previously measured insulin action in a large cohort of subjects (Insulin Resistance and Atherosclerosis Study [IRAS] Family Study) using the minimal model approach.12882937
Dilated Cardiomyopathy PathwayDeregulated Nutrient SensingEffect of beta-blockers on insulin resistance in patients with dilated cardiomyopathy.12890914
Doctor of ChiropracticDeregulated Nutrient SensingBeta-blocker therapy in patients with DCM improved not only cardiac function, but also insulin resistance.12890914
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Mucopolysaccharidosis IDeregulated Nutrient SensingHowever, after adjusting for age, sex, dyslipidemia, diabetes, hypertension and tobacco use, the difference in the prevalence of CAD between the various categories of MPS was not significant.12893021
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingThe clinical benefits of treating dyslipidemia in patients with diabetes should be at least equivalent to, if not more substantial than, the benefits observed among those with cardiovascular disease.12893398
Hepatitis CDeregulated Nutrient SensingInsulin resistance/beta-cell function and serum ferritin level in non-diabetic patients with hepatitis C virus infection.12895270
Hepatitis C, Liver diseasesDeregulated Nutrient SensingSince impaired glucose tolerance and iron overload are frequently demonstrated in hepatitis C virus (HCV)-related liver diseases, in this study we investigated insulin resistance, pancreatic beta-cell function, i.e., insulin secretion, and serum ferritin levels in patients with HCV infection, especially non-diabetic patients.12895270
Hepatitis C, Liver diseasesDeregulated Nutrient SensingInsulin resistance was connected with impaired glucose tolerance and the severity of liver diseases in non-diabetic patients with HCV infection.12895270
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe demonstrated that fasting insulin levels strongly inversely correlated with QUICKI in three different groups: 215 healthy nondiabetic nonobese subjects, 62 nondiabetic obese subjects, and 44 patients with glucose intolerance or type 2 diabetes mellitus.12897376
Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingPostprandial hypertriglyceridemia associated with insulin resistance is one of the cardiovascular risk factors in obesity and type 2 diabetes.12898471
Tumor necrosisDeregulated Nutrient SensingAllelic variants of the tumor necrosis factor-alpha (TNF-alpha) gene seem to contribute to insulin resistance increasing the transcription rate of TNF-alpha.12898475
diabeticDeregulated Nutrient SensingInsulin resistance, parameters of carbohydrate metabolism, anthropometric parameters, interactions in diabetic patients.12898939
diabeticDeregulated Nutrient SensingWe did not find any significant relationships between insulin resistance and anthropometric parameters in the diabetic group.12898939
Vascular Diseases, Lipid Metabolism Disorders, diabeticDeregulated Nutrient Sensing[Lipids disorder, macrovascular diseases, and insulin resistance in Chinese diabetic patients].12905764
Lipid Metabolism DisordersDeregulated Nutrient SensingInsulin resistance was more severe in all patients with lipid disorder except in L-HDL group, particularly in the HY-C-T-L-HDL group.12905764
Vascular Diseases, Lipid Metabolism Disorders, diabeticDeregulated Nutrient Sensing(2) Nearly two thirds of Chinese diabetic patients have lipid disorder, which is the strong risk factor of macrovascular diseases and aggravates insulin resistance.12905764
Hypertriglyceridemia, Lipid Metabolism DisordersDeregulated Nutrient Sensing(3) There was severe insulin resistance in patients with hypertriglyceridemia or with hypertriglyceridemia plus other lipid disorder.12905764
Increased insulin levelDeregulated Nutrient Sensing[Compensated hyperinsulinemia based on selective insulin resistance predicts elevation of blood pressure in non-diabetic adults].12905769
Increased insulin levelDeregulated Nutrient SensingTo investigate if hyperinsulinemia or insulin resistance could predict the elevation of blood pressure in non-diabetic adults.12905769
Diabetes MellitusDeregulated Nutrient SensingPossible contributing factors are elevated blood pressure values, changes in vascular reactivity, concentrations of lipids, fibrinogen and carboxyhemoglobin, in patients with diabetes mellitus, the quality of diabetes control and insulin resistance.12911864
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Beta-Cell Function MeasurementDeregulated Nutrient SensingThe onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance, and impaired beta-cell function.12915397
Hypokalemia, Cushing Syndrome, Diabetes MellitusDeregulated Nutrient SensingThis case is unusual in that the patient was relatively young and the clinical presentation of Cushing's syndrome was dominated by uncontrolled diabetes, insulin resistance, and hypokalemia.12917066
Postmenopausal stateDeregulated Nutrient SensingEffects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial.12917202
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe increase in blood pressure that accompanies the obese state is almost invariably associated with alterations in metabolism (insulin resistance and dyslipidaemia) and the neurohumoral profile (activation of the renin-angiotensin system, sympathetic overactivity), which potentiate the cardiovascular risk associated with hypertension.12923410
ObesityDeregulated Nutrient SensingObesity is characterised by a marked insulin resistance which involves an abnormal regulation of K(+) uptake and metabolism.12923648
ObesityDeregulated Nutrient SensingThe present data can be interpreted in the light of the insulin resistance syndrome of obesity, which causes an abnormal regulation of the Na-KATPase and of K(+) channels during physical exercise.12923648
Pancreatitis, Dyslipidemias, Liver diseasesDeregulated Nutrient SensingIn conclusion, Alstrom syndrome is a disease of systemic multi-organ involvement, and hepatic disease and pancreatitis, possibly due to dyslipidemia, appear to be manifestations of Alstrom syndrome.12926522
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingInsulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes.12933352
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a key pathogenic factor of type 2 diabetes (T2DM); in contrast, in type 1 diabetes (T1DM) it is considered a secondary alteration.12933352
HyperglycemiaDeregulated Nutrient SensingIn conclusion, in T1DM, T2DM, and OFF, IMCL content was associated with insulin resistance, demonstrating that IMCL accretion is a marker of insulin resistance common to both primary genetically determined and secondary metabolic (chronic hyperglycemia) alterations.12933352
Acute myocardial infarctionDeregulated Nutrient SensingThe effect of insulin resistance (IR) on the fatty acid metabolism of myocardium, and therefore on the recovery of left ventricular (LV) wall motion, has not been established in patients with acute myocardial infarction (AMI).12939551
Heart Diseases, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingDyslipidemias, hypertension, obesity, cigarette smoking and cardiac diseases were found to be the most prevalent single risk factors.12940842
Dyslipidemias, ObesityDeregulated Nutrient Sensing[Effect of oral inulin administration on lipid profile and insulin sensitivity in subjects with obesity and dyslipidemia].12942586
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin lispro reduces insulin antibodies in a patient with type 2 diabetes with immunological insulin resistance.12951276
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingDrug therapy management (DTM) for patients with dyslipidemias identified frequent drug therapy problems associated with both hyperlipidemia and other conditions.12952316
AcromegalyDeregulated Nutrient SensingEvaluation of insulin resistance in acromegalic patients before and after treatment with somatostatin analogues.12952367
Endothelial dysfunctionDeregulated Nutrient SensingEndothelial dysfunction and insulin resistance have been strongly associated with reduced vascular reactivity in T2DM.12954157
Cardiovascular DiseasesDeregulated Nutrient SensingRelation of insulin resistance to markers of preclinical cardiovascular disease: the Strong Heart Study.12955795
Hypercholesterolemia, Glucose Intolerance (disease), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe prevalence of severe hypertension and current smoking significantly decreased, while that of glucose intolerance, hypercholesterolemia, and obesity greatly increased among the cohorts.12958323
DiseaseDeregulated Nutrient SensingTo determine whether serum gamma GTP activity could be associated with the status of various disorders caused by increased insulin resistance levels, namely, insulin resistance syndrome, a cross-sectional study for 11,884 Japanese men was performed.12960502
Inflammation, Dyslipidemias, Venous Thromboembolism, vinyltriethoxysilaneDeregulated Nutrient SensingVenous thromboembolism (VTE) involves inflammation and a relation with dyslipidemia which remains controversial.12969812
Diabetes MellitusDeregulated Nutrient SensingA low birth weight is associated with insulin resistance and type 2 diabetes.12974743
AtherosclerosisDeregulated Nutrient SensingThese results indicate that doxazosin can be used safely in patients with insulin resistance, while its positive effect on endothelial function may lessen the subsequent incidence of atherosclerosis.14506621
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Acanthosis Nigricans, LipodystrophyDeregulated Nutrient SensingThe lipodystrophy causes severe insulin resistance, resulting in acanthosis nigricans, diabetes, dyslipidaemia, and increased risk of cardiovascular disease.14510863
AcromegalyDeregulated Nutrient SensingIn acromegalic patients, somatostatin analogues treatment reduces insulin resistance, and also impairs insulin secretion.14510913
Hypertension, CTCAEDeregulated Nutrient SensingThe association of insulin resistance (IR) and essential hypertension is well known, but a causal relationship has not been proven.14511355
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance (IR) commonly is associated with nonalcoholic steatohepatitis (NASH).14512888
Hepatobiliary Disorder, Fatty Liver DiseaseDeregulated Nutrient SensingIn conclusion, improving insulin sensitivity with rosiglitazone resulted in improved histologic markers of NASH, an observation suggesting that insulin resistance contributes to its development and that improving insulin sensitivity may be important in treating this liver disease.14512888
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingAmong Japanese Americans, CRP may be a risk factor for development of type 2 diabetes independent of either obesity or insulin resistance.14514575
Diabetes MellitusDeregulated Nutrient SensingThe Accelerator Hypothesis predicts earlier onset in heavier people, without necessarily a change in risk, and views type 1 and type 2 diabetes as the same disorder of insulin resistance, set against different genetic backgrounds.14514593
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a function of fat mass, and increasing body weight in the industrialized world has been accompanied by earlier presentation (i.e., acceleration) of type 2 diabetes.14514593
Tumor necrosis, Cardiovascular DiseasesDeregulated Nutrient SensingLeptin and tumor necrosis factor (TNF)-alpha are associated with insulin resistance and cardiovascular disease.14514596
AtherosclerosisDeregulated Nutrient SensingInsulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.14514631
Weight Gain, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWith intensive therapy, subjects with a family history of type 2 diabetes had greater central weight gain and dyslipidemia characterized by higher triglyceride levels and greater cholesterol in VLDLs and intermediate-density lipoproteins compared with subjects with no family history.14514648
Dyslipidemias, Myocardial Ischemia, Hyperuricemia, Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingThe choice of antihypertensives in relation to comorbidities and laboratory findings revealed that many hypertensive patients with dyslipidemia were on beta-blockers and diuretics, 39.3% of patients with ischemic heart disease were on beta-blockers, approximately 20% of patients with hyperuricemia were on diuretics, and 27.6% and 10.4% of patients with isolated systolic hypertension were on diuretics and calcium-channel blockers, respectively.14519051
Uremia, Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance, a strong risk factor for atherosclerotic vascular disease, is present in uremic patients without diabetes on continuous ambulatory peritoneal dialysis (CAPD) therapy.14520628
Cardiac complicationDeregulated Nutrient SensingAmelioration of insulin resistance may reduce associated long-term cardiovascular complications.14520628
Diabetes MellitusDeregulated Nutrient SensingROS improved insulin resistance in CAPD patients without diabetes.14520628
Cardiovascular DiseasesDeregulated Nutrient SensingIt is now well recognised that, in addition to total body fat, fat distribution is a major risk factor for cardiovascular disease and insulin resistance/diabetes in both adults and children.14522692
Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingKidney transplant recipients are not only prone to dyslipidemia but also have a high risk of cardiovascular death.14529894
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingUremic dyslipidemia characterized by reduced high-density lipoprotein (HDL) cholesterol levels is one of the major contributors to the high incidence of cardiovascular disease in hemodialysis patients.14531818
Hyperlipidemia, Obesity, Abdominal, diabeticDeregulated Nutrient SensingUnlike the 747 normoglycemic patients, both IFG (n=94) and diabetic (n=267) subjects showed an insulin resistance profile, with abdominal obesity, and dislipidemia characterized by high triglycerides in the presence of low high density lipoprotein-cholesterol and high normal or elevated blood pressure.14532941
Dyslipidemias, Overweight, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of dyslipidaemia hypertension and diabetes were significantly increased in overweight and obese groups.14535102
DyslipidemiasDeregulated Nutrient SensingRagaglitazar is a novel dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist intended to restore insulin sensitivity and correct diabetic dyslipidemia.14551179
Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance and other risk factors for coronary heart disease in elderly men.14555884
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe risk of CHD increased 2.5-fold in known diabetics compared with those with normal glucose tolerance, 2.2-fold among those in the highest compared with the lowest quintile of insulin resistance, and 2.4-fold among those in the highest compared with the lowest quintile of fasting insulin.14555884
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance is a significant risk factor for CHD.14555884
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt has been suggested that Japanese, categorized as having normal weight (BMI<25.0), as defined by WHO (2000), have a tendency toward increased incidences of dyslipidemia and diabetes.14557832
Dyslipidemias, ObesityDeregulated Nutrient SensingThe Mongolians had a higher prevalence of obesity and a higher body fat percent, but a lesser gradation of dyslipidemia, than did the BMI-matched Japanese groups.14557832
diabeticDeregulated Nutrient SensingPlatelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients.14564674
diabeticDeregulated Nutrient SensingThese results indicate that not only BMI, HbA(1c), and triglycerides levels but also platelet counts are independent predictor of insulin resistance in non-obese Japanese type 2 diabetic patients.14564674
Hypoadiponectinemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus.14564678
HypoadiponectinemiaDeregulated Nutrient SensingBoth subcutaneous and visceral fat accumulation contribute to insulin resistance in these subjects, and the contribution of visceral fat may be mediated, in part, by hypoadiponectinemia.14564678
diabeticDeregulated Nutrient SensingArterial wall thickness is associated with insulin resistance in type 2 diabetic patients.14566088
diabeticDeregulated Nutrient SensingThe aim of the present study was to investigate the independent association of the intimal-medial thickness of carotid and femoral arteries (CA-IMT and FA-IMT), a marker of atheroscelosis, with insulin resistance in type 2 diabetic patients.14566088
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe evaluated CA-IMT and FA-IMT by high-resolution ultrasonography and insulin resistance determined by euglycemic hyperinsulinemic clamp in 119 type 2 diabetic subjects, 71 males and 48 females (age, 54 +/- 12 (SD) years).14566088
Diabetes Mellitus, Non-Insulin-Dependent, diabetic, AtherosclerosisDeregulated Nutrient SensingIn conclusion, insulin resistance is associated with both CA-IMT and FA-IMT in type 2 diabetic patients, suggesting that it is an independent risk factor for the development of atherosclerosis in type 2 diabetes.14566088
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe following variables showed a positive correlation with dyslipidemia: increased age (P<0.001), male sex (P<0.001), low familial income (P<0.001), familial history (P<0.01), overweight/obesity (P<0.001), waist measure (P<0.001), high blood pressure (P<0.001), and diabetes mellitus (P<0.001).14569370
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe following prevalences were observed: of dyslipidemias 24.2%; of hypercholesterolemia, 4.2%; of elevated LDL-C, 3.5%; of low HDL-C, 18.3%; and of hypertriglyceridemia, 17.1%.14569370
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingSex, age, dyslipidemia, obesity, hypertension, clinic cardiac status, coronary angiographic lesions and coronary revascularisation procedures were noted.14573964
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffective exercise modality to reduce insulin resistance in women with type 2 diabetes.14578226
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingIslet amyloid has been suggested to be an important link between insulin resistance and beta-cell dysfunction in type 2 diabetes.14578294
Failure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings suggest that islet amyloid deposits reflect greater insulin resistance and islet failure in a subgroup of type 2 diabetic patients.14578294
diabeticDeregulated Nutrient SensingInsulin resistance was computed with linear regression based on an equation previously validated in clamp studies on type 1 diabetic adults.14578303
SLC25A20 gene, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance was associated with CAC (OR 1.6 in type 1 diabetes and 1.4 in control subjects, P < 0.001), independent of coronary artery disease risk factors.14578303
diabeticDeregulated Nutrient SensingAfter adjusting for insulin resistance, the CAC male excess in diabetic patients decreased from OR 2.2 (P < 0.001) to 1.8 (P = 0.04).14578303
Calcification of coronary artery, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men.14578303
Diabetes Mellitus, Non-Insulin-Dependent, DiseaseDeregulated Nutrient SensingType 2 diabetes is a heterogeneous disorder characterized by defects in the early phase of insulin secretion after meals and in insulin resistance at its early stage.14581145
Peripheral Vascular Diseases, Increased insulin levelDeregulated Nutrient SensingAlthough age, FPG, plasma HbA1c, serum total-cholesterol, HDL-cholesterol concentrations, and systolic and diastolic blood pressure were at same levels in group A as group B, body mass index, HOMA-R, serum triglyceride concentrations were significantly higher in group A, indicating the existence of insulin resistance in group A. Hyperinsulinemia may be involved in the development of PVD in moderately hyperglycemic patients.14581153
AtherosclerosisDeregulated Nutrient SensingComparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the Insulin Resistance Atherosclerosis Study (IRAS).14581403
Vascular Diseases, Thrombosis, Inflammation, Atherosclerosis, Dyslipidemias, Dysglycemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingRisk factors for vascular disease include obesity, dyslipidemia, hypertension, dysglycemia, insulin resistance, inflammation, thrombosis, and subclinical atherosclerosis.14581403
Increased insulin level, Thrombosis, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThere were significant differences in measures of abdominal obesity, dyslipidemia, hyperinsulinemia, and thrombosis between subjects with elevated apoB but normal LDLC versus those with elevated LDLC but normal apoB.14581403
Diabetes Mellitus, Obesity, Insulin resistance syndromeDeregulated Nutrient SensingThese considerations may rationalize recent evidence that high dietary intakes of calcium and/or dairy products may reduce risk for obesity, diabetes, and insulin-resistance syndrome, and they predict that other dietary measures which down-regulate PTH - such as good vitamin D status, and moderation in phosphate and salt intakes - may likewise be beneficial in these respects.14592784
HyperparathyroidismDeregulated Nutrient SensingConsistent with this position are reports that body weight is elevated in elderly subjects with both primary and secondary hyperparathyroidism; furthermore, insulin resistance is a well-known complication of both forms of hyperparathyroidism.14592784
Obesity, Diabetes MellitusDeregulated Nutrient SensingThe fact that regular alcohol consumption is associated with decreased PTH secretion may help to explain why moderate drinkers are less prone to insulin resistance, diabetes, and - in women - obesity.14592784
Hyperglycemia, Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingCompared with a similar-size subpopulation with high body mass index, persons with EWET were older and had more dyslipidemia, hyperglycemia, and hyperuricemia.14594778
Dyslipidemias, Increased insulin level, Prediabetes syndrome, HyperuricemiaDeregulated Nutrient SensingCompared with "prediabetes," EWET identified more persons with hyperinsulinemia, dyslipidemia, and hyperuricemia.14594778
AtherosclerosisDeregulated Nutrient SensingWhole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study.14594783
AtherosclerosisDeregulated Nutrient SensingWe evaluated data from the Insulin Resistance Atherosclerosis Study (IRAS Exam I, 1992-1994).14594783
Hippocampal atrophy, Diabetes MellitusDeregulated Nutrient SensingWe investigated the association between diabetes mellitus, insulin resistance and the degree of hippocampal and amygdalar atrophy on magnetic resonance imaging (MRI) accounting for vascular pathology.14595538
Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes mellitus and, in non-diabetic subjects, insulin resistance was assessed for 506 participants in whom hippocampal and amygdalar volumes on MRI were measured.14595538
Amygdaloid structureDeregulated Nutrient SensingFurthermore, increasing insulin resistance was associated with more amygdalar atrophy on MRI.14595538
Fatty Liver, Hyperlipidemia, Diabetes Mellitus, Fatty Liver DiseaseDeregulated Nutrient SensingWhen a patient on a glucocorticoid therapy shows signs of fatty liver, diabetes mellitus, hyperlipidemia, an insulin resistance, NASH should be considered as one of the differential diagnosis.14598660
Hyperglycemia, No metabolic abnormalitiesDeregulated Nutrient SensingApparently, it results from insulin resistance and hyperglycaemia and contributes to coexisting metabolic abnormalities.14601484
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLow PON1 has been shown in oxidative stress-associated processes such as dyslipidemia, diabetes mellitus, advancing age, and smoking.14602783
Glucose Intolerance (disease)Deregulated Nutrient SensingThese results suggest that a high intake of alcohol and a decreased P/S ratio contribute to the risk of glucose intolerance in contemporary Japanese.14604220
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe observations in dyslipidaemic Asian Indians suggest high prevalence rates of generalized and abdominal obesity, and that high values of W-HR alone predisposes to atherogenic dyslipidaemia.14604306
Dyslipidemias, ObesityDeregulated Nutrient SensingThe revised criteria for the BMI-based diagnosis of obesity will lead to a more rational management of dyslipidaemia in Asian Indians.14604306
DyslipidemiasDeregulated Nutrient SensingMeasurement or anticipation of patients most susceptible to lipoprotein subfraction abnormalities may influence therapeutic choices for the optimal management of dyslipidemia.14605511
HIV InfectionsDeregulated Nutrient SensingInsulin resistance complicating pregnancy in a human immunodeficiency virus-infected patient treated with protease inhibitors and corticosteroids.14607060
Premature Obstetric LaborDeregulated Nutrient SensingWe report a case of a pregnant HIV-infected woman receiving highly active antiretroviral therapy who developed acute onset of severe insulin resistance during treatment for preterm labor.14607060
Glucose Intolerance (disease), HIVDeregulated Nutrient SensingProtease inhibitor therapy in human immunodeficiency virus (HIV)-infected adults has been associated with onset or aggravation of glucose intolerance.14607060
Glucose Intolerance (disease)Deregulated Nutrient SensingWe found that HIV-positive pregnant women receiving highly active antiretroviral therapy may be at increased risk for development of glucose intolerance.14607060
Increased insulin levelDeregulated Nutrient SensingWaist-to-hip ratio (WHR) is a marker for insulin resistance and hyperinsulinemia.14607804
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients.14610526
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe aims of this study were to test the possible association between nonalcoholic fatty liver disease (NAFLD) and iron and insulin resistance, and to determine the prevalence of NAFLD in apparently healthy obese subjects.14610526
Fatty LiverDeregulated Nutrient SensingMultiple logistic regression analysis showed waist circumference and insulin resistance to be independently associated with fatty liver.14610526
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingSerum ferritin level and insulin resistance were two major risk factors predicting NAFLD.14610526
Increased insulin level, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAs both hyperinsulinemia induced by insulin resistance and iron overload represented by ferritin elevation might damage hepatocytes, we concluded that these two factors were significantly associated with NAFLD in obese patients.\14610526
TG gene, Dyslipidemias, Federated States of MicronesiaDeregulated Nutrient SensingFor %FM and FM(trunk)/FM(legs) in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia.14610531
TG gene, DyslipidemiasDeregulated Nutrient SensingIn males, ORs of the third tertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia.14610531
Dyslipidemias, Federated States of MicronesiaDeregulated Nutrient SensingExcess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects.14610531
insulinomaDeregulated Nutrient SensingExtended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.14613923
Microunit per MilliliterDeregulated Nutrient SensingSouth Asians had greater insulin resistance than Europeans (fasting insulin geometric mean, 7.1 versus 4.7 microU/ml, and 2-h insulin, 37.3 versus 14.1 microU/ml, respectively).14614356
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTo establish the population-level predictive validity of the Framingham Heart Study risk equation used to derive cardiovascular disease risk-prediction charts for New Zealand management guidelines on raised blood pressure and dyslipidaemia.14615804
ObesityDeregulated Nutrient SensingThe highest correlations were noted between the insulin resistance factor and the obesity factor (r = 0.887) and the insulin resistance factor and the lipid factor (r = 0.835).14617224
Hypertensive (finding)Deregulated Nutrient SensingA higher intensity of medical treatment is needed to achieve BP control in obese hypertensive patients characterized by insulin resistance.14620926
Hypertension, CTCAEDeregulated Nutrient SensingThese findings suggest an important role of insulin resistance in predicting the future incidence of hypertension in middle-aged Japanese men.14621182
Diabetes Mellitus, Non-Insulin-Dependent, Overweight, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is more common in overweight individuals and is associated with increased risk for type 2 diabetes mellitus and cardiovascular disease.14623617
Weight decreased, Overweight, ObesityDeregulated Nutrient SensingGiven the current epidemic of obesity and the fact that lifestyle interventions, such as weight loss and exercise, decrease insulin resistance, a relatively simple means to identify overweight individuals who are insulin resistant would be clinically useful.14623617
Overweight, Cardiovascular DiseasesDeregulated Nutrient SensingTo evaluate the ability of metabolic markers associated with insulin resistance and increased risk for cardiovascular disease to identify the subset of overweight individuals who are insulin resistant.14623617
Hepatobiliary DisorderDeregulated Nutrient SensingElevated levels of IGFBP-1 in liver disease have been attributed to insulin resistance; however, the relationships between these analytes have not been defined.14624764
Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, ST3GAL4 geneDeregulated Nutrient SensingWe concluded that the new rat model of type 2 diabetes established with conjunctive treatment of low dose of STZ and high fat diet was characterized by hyperglycemia and light impaired insulin secretion function accompanied by insulin resistance, which resembles the clinical manifestation of type 2 diabetes.14625406
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingAn evaluation of pharmaceutical treatment of dyslipidaemia among patients without diagnosed atherosclerotic disease in Belgium.14627185
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is caused by reduced insulin secretion and insulin resistance in skeletal muscle and liver.14633813
Metabolic Syndrome XDeregulated Nutrient SensingHowever, this might be reflecting the cluster of risk factors, associated with metabolic syndrome, in which insulin resistance plays a major role.14634687
HyperinsulinismDeregulated Nutrient SensingIntima-media thickness of the carotid arteries in subjects with hyperinsulinaemia (insulin resistance).14635730
Hyperinsulinism, Metabolic Syndrome X, AtherosclerosisDeregulated Nutrient SensingThe metabolic syndrome is characterised by hyperinsulinaemia (insulin resistance) leading to an increased risk of atherosclerotic cardiovascular diseases.14635730
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingSubjects were divided into subgroups according to the stages of glucose intolerance (normal glucose tolerance, n = 46; impaired glucose tolerance, n = 26; diabetes mellitus, n = 19).14635730
Glucose Intolerance (disease)Deregulated Nutrient SensingIn hyperinsulinaemic subjects only a trend of increasing IMT values and that of decreasing lumen diameter of the internal carotid arteries were observed when subgroups classified according to the stages of glucose intolerance were compared.14635730
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreases in PKC-theta (the major isoenzymic form of PKC in skeletal muscle) protein and isozyme activity have been reported in skeletal muscle from patients with type 2 diabetes mellitus (T2DM) and dietary-induced rodent models of insulin resistance, but the underlying biochemical mechanism is unclear and muscle PKC-theta mRNA expression has not been previously reported in patients with T2DM or in relation to in-vivo measurements of insulin sensitivity.14636302
Glucose Intolerance (disease), AcromegalyDeregulated Nutrient SensingInsulin resistance leading, in some cases, to glucose intolerance is an important contributory factor to the cardiovascular morbidity and mortality associated with acromegaly.14640992
Steatohepatitis, Cushing Syndrome, ObesityDeregulated Nutrient SensingHepatic steatosis may occur in association with insulin resistance and obesity, two features commonly seen in Cushing's syndrome (CS).14640995
Hypertension, CTCAE, Complications of Diabetes Mellitus, DyslipidemiasDeregulated Nutrient SensingTwo hundred and ninety-five patients were divided into the T2DM group (n = 233) and the LADA group (n = 62) to compare the age of onset, body mass index, HbA(1c), C-peptide, hypertension, dyslipidemia and chronic diabetic complications.14642146
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingCompared with T2DM, LADA patients were younger at their ages of onset, had lower C-peptide and body mass index, and also had less cases with hypertension and with dyslipidemia.14642146
Diabetes MellitusDeregulated Nutrient SensingBirthweight of offspring and paternal insulin resistance and paternal diabetes in late adulthood: cross sectional survey.14647894
Diabetes MellitusDeregulated Nutrient SensingTo confirm this we examined the association between offspring birthweight and paternal insulin resistance and diabetes in late adulthood.14647894
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingOffspring birthweight is inversely associated with paternal insulin resistance and diabetes in late adulthood, supporting the hypothesis that genetic factors related to insulin action contribute to the association between birthweight and adult cardiovascular disease and diabetes risk.14647894
DyslipidemiasDeregulated Nutrient SensingIn 62% of 18,627 patients who also had dyslipidemia, low-density lipoprotein cholesterol was less than 130 mg/dL.14650370
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEvaluation of human resistin assays with serum from patients with type 2 diabetes and different degrees of insulin resistance.14651328
ObesityDeregulated Nutrient SensingResistin is a peptide hormone encoded at the RSTN gene that since its detection in mice is considered to be an important link between obesity and insulin resistance.14651328
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingMany of our patients (54%-97%) with dyslipidemia would not have been eligible for inclusion in earlier studies of hyperlipidemia and primary prevention.14651827
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe presence of seven health risk indicators (obesity, dyslipidemia, high blood pressure, diabetes mellitus, sedentary lifestyle, smoking, and excessive alcohol use) was assessed.14664303
Dyslipidemias, ObesityDeregulated Nutrient SensingFour risk indicators (obesity, dyslipidemia, high blood pressure, and sedentary lifestyle) were identified as significant areas of concern.14664303
Polycystic Ovary SyndromeDeregulated Nutrient SensingRelationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome.14667885
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingTo test the interdependence between insulin resistance (IR) and gonadotropin dissociation (GD) in polycystic ovary syndrome (PCOS).14667885
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingInsulin resistance and GD do not appear to be related events in PCOS, suggesting that each one might be determined by different genetic disorders.14667885
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe conclude that improvement of glycemic control in type 2 diabetes improves most of the components of diabetic dyslipidemia, including a shift towards larger LDL particles in subjects with phenotype B.14669158
Tumor necrosisDeregulated Nutrient SensingWhat is the contribution of differences in three measures of tumor necrosis factor-alpha activity to insulin resistance in healthy volunteers?14669161
Depression, CTCAEDeregulated Nutrient SensingAssociation of insulin resistance with depression: cross sectional findings from the British Women's Heart and Health Study.14670883
Cushing Syndrome, Adrenal incidentaloma, OverweightDeregulated Nutrient SensingSubclinical Cushing's syndrome (SCS) caused by adrenal incidentalomas is frequently associated with overweight and insulin resistance.14671173
Hepatitis B, Chronic, Non-cirrhoticDeregulated Nutrient SensingMechanisms of increased insulin resistance in non-cirrhotic patients with chronic hepatitis C virus infection.14675263
Non-cirrhoticDeregulated Nutrient SensingIn the present study, the authors focused on non-cirrhotic and non-diabetic patients with chronic HCV infection and evaluated the factors responsible for increases in insulin resistance.14675263
Fibrosis AssessmentDeregulated Nutrient SensingHomeostasis model assessment of insulin resistance and IRI levels increased parallel with the progression of fibrosis.14675263
Inflammation, Fibrosis Assessment, Hepatitis CDeregulated Nutrient SensingCollectively, hepatic fibrosis and inflammation appear to play key roles in the increase in insulin resistance in patients with chronic HCV infection.14675263
Hyperhomocysteinemia, Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingWithin the various patient groups and often despite treatment, there was a high prevalence of hypertension, smoking, dyslipidaemia, hyperhomocystemia and overweight.14677480
Diabetes, AutoimmuneDeregulated Nutrient SensingInsulin resistance in latent autoimmune diabetes of adulthood.14679095
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes.14679095
Diabetes MellitusDeregulated Nutrient SensingMean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes.14679095
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingExcessive iron stores may promote insulin resistance and lead to the development of type 2 diabetes.14684399
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe independent risk factors associated with the maximum IMT were age, diabetes mellitus, smoking, and intact parathyroid hormone (PTH) (R = 0.569, p < 0.0001), while factors associated with the mean IMT were age, hypertension, dyslipidemia, intact PTH, and lipoprotein (a) (R = 0.602, p < 0.0001).14686748
HypertriglyceridemiaDeregulated Nutrient SensingDiurnal TG profiles can be used to investigate postprandial lipaemia in both lean and mildly obese subjects and may help to detect subjects with an underlying disposition for hypertriglyceridaemia related to insulin resistance, i.e.14687241
Diabetes Mellitus, Non-Insulin-Dependent, Blood GlucoseDeregulated Nutrient SensingDecrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects.14693409
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a key characteristic of first-degree relatives of patients with type 2 diabetes.14693981
HeredityDeregulated Nutrient SensingThese results suggest that heredity explains a substantial proportion of the variability of the factors that underlie the insulin resistance syndrome in American Indians and that these factors are genetically independent.14694207
ObesityDeregulated Nutrient SensingThe pathogenesis has been related to metabolic risk factors, insulin resistance, and obesity.14694226
Obesity, AtherosclerosisDeregulated Nutrient SensingThis study was designed to examine the relationship between obesity and regional patterns of adiposity, insulin resistance, and five independent measures of subclinical atherosclerosis.14694226
Vascular Diseases, Atheroma, Hyperglycemia, ObesityDeregulated Nutrient SensingThese findings suggest that obesity may play an important role in the early phase of subclinical macrovascular disease related to vessel stiffness, whereas hyperglycemia and insulin resistance in conjunction with other risk factors have important roles in progression from vessel stiffness to atheroma formation in type 2 diabetes.14694226
Inflammation, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and non-traditional cardiovascular (CV) risk factors, such as lipoprotein(a) (Lp(a)), homocysteine, oxidative stress and inflammation, are important determinants in the increased CV risk of hemodialysis (HD) patients.14694274
Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingObesity is an important risk factor for the occurrence of coronary artery disease (CAD) in Western countries and furthermore, it often coexists with other CAD risk factors such as hypertension, dyslipidemia and diabetes mellitus.14695464
Diabetes MellitusDeregulated Nutrient SensingAssociations of measures of lung function with insulin resistance and Type 2 diabetes: findings from the British Women's Heart and Health Study.14704837
Diabetes MellitusDeregulated Nutrient SensingForced expiratory flow in the central period of FVC was not associated with insulin resistance or diabetes.14704837
Diabetes MellitusDeregulated Nutrient SensingLung function measures which predominantly reflect lung volume are inversely associated with insulin resistance and Type 2 diabetes.14704837
SMN1 wt AlleleDeregulated Nutrient SensingHigh-titre ANA but not SMA positivity is associated with insulin resistance.14705824
Hypertensive (finding)Deregulated Nutrient SensingOur data suggest that increased circulating insulin, not the state of insulin resistance, suppresses urine 20-HETE excretion in obese hypertensive subjects.14707157
Diabetes Mellitus, Acth-Independent Macronodular Adrenal HyperplasiaDeregulated Nutrient SensingUnilateral adrenalectomy improves insulin resistance and diabetes mellitus in a patient with ACTH-independent macronodular adrenal hyperplasia.14709842
Microunit per MilliliterDeregulated Nutrient SensingFasting insulin concentration was increased to 42.6 microU/ml, and the homeostasis model insulin resistance index (HOMA-R) was calculated to be 15.5 (with a normal range of less than 2.5), indicating severe insulin resistance.14709842
Glucose Intolerance (disease), Cushing SyndromeDeregulated Nutrient SensingInsulin resistance and glucose intolerance are recognized as features of mild hypercortisolism.14709842
Dyslipidemias, Hypopituitarism, ObesityDeregulated Nutrient SensingDyslipidemia and obesity are common in adult patients with hypopituitarism.14709849
Rhabdomyolysis, DyslipidemiasDeregulated Nutrient SensingAlthough rhabdomyolysis is a rare adverse event associated with this class of drugs, their prevalent use in the management of dyslipidemia makes it increasingly important for clinicians to understand the nature of this condition.14712320
Steatohepatitis, dysmetabolic syndrome, Precocious, Diabetes MellitusDeregulated Nutrient SensingThe patient presented also a complex dysmetabolic syndrome characterized by insulin resistance, diabetes mellitus type 2, acanthosis nigricans, liver steatohepatitis, and signs of precocious atherogenesis.14715828
Diabetes MellitusDeregulated Nutrient SensingHigh doses of testosterone treatment resulted in a severe imbalance in the estradiol to testosterone ratio together with the occurrence of insulin resistance and diabetes mellitus type 2.14715828
Acanthosis Nigricans, SteatohepatitisDeregulated Nutrient SensingEstrogen treatment resulted in an improvement of acanthosis nigricans, insulin resistance, and liver steatohepatitis, coupled with a better glycemic control and the disappearance of two carotid plaques.14715828
ObesityDeregulated Nutrient SensingResistin is an adipocyte-derived peptide that might play a role in obesity and insulin resistance.14715842
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingIn conclusion, plasma resistin concentrations are elevated in patients with type 2 diabetes, but are not associated with insulin resistance or obesity.14715842
ObesityDeregulated Nutrient SensingObesity is characterized by increased leptin levels and insulin resistance, whereas blunted GH secretion is paired with normal, low, or high plasma IGF-I levels.14715846
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe present results suggested that radiation dose was related to 1) fatty liver, which clustered the metabolic CHD risk factors associated with insulin resistance syndrome and 2) atherogenic lipid profiles.14717339
Periodontitis, StressDeregulated Nutrient SensingStress is associated with poor oral hygiene, increased glucocorticoid secretion that can depress immune function, increased insulin resistance and potentially increased risk of periodontitis.14719755
Cessation of life, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWhen only one of the 3 risk factors, namely hypertension, dyslipidemia and smoking, was present, CVD accounted for 36.8% of all deaths; when all the 3 factors co-existed, CVD accounted for 50% of all deaths.14724116
Fibrosis Assessment, Hepatitis B, ChronicDeregulated Nutrient SensingInsulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected].14724822
Hepatitis B, Chronic, fibrogenesisDeregulated Nutrient SensingWe hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection.14724822
Hepatobiliary DisorderDeregulated Nutrient SensingHepatitis C virus may induce insulin resistance irrespective of the severity of liver disease, and this effect seems to be genotype specific.14724822
Hepatitis CDeregulated Nutrient SensingFurther, our findings support the hypothesis that insulin resistance may contribute to fibrotic progression in chronic hepatitis C virus infection.14724822
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance plays a major aetiological role in the development of fatty liver disease.14725689
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe inverse association between birth weight and CHD may in part be mediated via insulin resistance.14729890
HIV-Associated Lipodystrophy SyndromeDeregulated Nutrient SensingThis study tested the hypothesis that in patients with HIV-associated lipodystrophy, adiponectin levels were related to insulin resistance, TNF-alpha and IL-6 and treatment with nucleoside analogues.14738456
Lipodystrophy, Adipose Tissue AtrophyDeregulated Nutrient SensingIn conclusion, the finding of no difference between the two lipodystrophic groups with regard to adiponectin, indicates that low levels of adiponectin reflects fat atrophy, whereas the insulin resistance was best explained by increased truncal fat mass.14738456
ObesityDeregulated Nutrient SensingResistin is thought to be an important link between obesity and insulin resistance.14740159
ObesityDeregulated Nutrient SensingIt has been suggested that genetic polymorphism in the promoter of resistin gene is a determinant of resistin mRNA expression and possibly associated with obesity and insulin resistance.14740159
Diabetes MellitusDeregulated Nutrient SensingThe presence of CAD was associated with current, past or passive smoking, a history of diabetes and high blood pressure, a positive family risk factors in this study; levels were below history of CAD, body fat percentage, waist-hip ratio (WHR), low apolipoprotein A1 or low HDL, lipoprotein (a), glucose, insulin, insulin resistance, C-reactive protein (CRP), total cholesterol to HDL ratio (TC/HDL) and creatinine on univariate conditional logistic regression analysis.14741073
Periodontal Diseases, Dyslipidemias, Endothelial dysfunction, Cardiovascular DiseasesDeregulated Nutrient SensingBased on our data, periodontal disease showed significant associations with biomarkers of endothelial dysfunction and dyslipidemia, which may potentially mediate the association between periodontal and cardiovascular disease.14742654
deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingType 2 diabetes is associated with insulin deficiency and insulin resistance and, increasingly, with patients who are overweight or obese.14742789
Diabetes Mellitus, Non-Insulin-Dependent, Endothelial dysfunctionDeregulated Nutrient SensingIn type 2 diabetes, rosiglitazone therapy for insulin resistance ameliorates endothelial dysfunction independent of glucose control.14747233
ArteriosclerosisDeregulated Nutrient SensingInsulin resistance is an independent risk factor for arteriosclerosis and cardiovascular mortality.14747233
ArteriosclerosisDeregulated Nutrient SensingHowever, the mechanism by which insulin resistance contributes to arteriosclerosis is unknown.14747233
Endothelial dysfunctionDeregulated Nutrient SensingTherefore, we asked whether therapy for insulin resistance ameliorates any endothelial dysfunction.14747233
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a major contributor toward endothelial dysfunction in type 2 diabetes.14747233
Endothelial dysfunctionDeregulated Nutrient SensingBoth endothelial dysfunction and insulin resistance are amenable to treatment by rosiglitazone.14747233
Diabetes MellitusDeregulated Nutrient SensingWhile the incidence of diabetes increases with age, a decrease in beta-cell function independent of age-related insulin resistance has not been conclusively determined.14747296
HyperglycemiaDeregulated Nutrient SensingHowever, after hyperglycemia for an additional 2 h, the ability to maintain insulin secretion, commensurate with the degree of insulin resistance, was decreased in all aging rats (P < 0.05).14747296
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingC/IF plaques correlated with age, tobacco consumption, diabetes mellitus, and dyslipidaemia.14749711
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFour cardiovascular risk factors seem to be involved in these alterations, namely tobacco consumption, dyslipidaemia, diabetes and increased PP.14749711
Fibrosis Assessment, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingRelative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver.14752836
HFE gene, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Obesity, Fibrosis, LiverDeregulated Nutrient SensingOur goal was to define the relative impact of iron overload, genetic mutations of HFE, and insulin resistance on the severity of liver fibrosis in a population of subjects with nonalcoholic fatty liver disease (NAFLD) who had low prevalence of obesity and no overt symptoms of diabetes.14752836
Fibrosis Assessment, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn conclusion, the current study indicates that insulin resistance is a major, independent risk factor for advanced fibrosis in patients with NAFLD.14752836
Dyslipidemias, ObesityDeregulated Nutrient SensingWe underline strong association with dyslipidemia and obesity.14755953
Hypertension, CTCAE, Coronary Arteriosclerosis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe were looking for clinical and biological criteria of diabetes and co-morbidities (hypertension, dyslipidemias, ischaemic heart diseases).14755953
Increased insulin levelDeregulated Nutrient SensingThe uniform pattern of OGTT values was considered due to insulin resistance and hyperinsulinism.14755979
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingIn conclusion fenofibrate is the drug which can be choose in diabetic dyslipidemia without cardiac disease.14756060
Increased insulin level, Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingThe growing recognition that colorectal cancer may be promoted by hyperinsulinemia and insulin resistance suggests that a diet inducing high blood glucose levels and an elevated insulin response may contribute to a metabolic environment conducive to tumor growth.14759990
Hypertensive (finding)Deregulated Nutrient SensingExercise blood pressure is related to insulin resistance in subjects with two hypertensive parents.14763663
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance has been implicated in the pathogenesis of essential hypertension.14763663
Hypertension, CTCAEDeregulated Nutrient SensingSince elevated blood pressure during physical exertion is a predictor of future hypertension, these findings may suggest that insulin resistance is involved in the pathogenesis of essential hypertension.14763663
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise.14764782
Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingCommon associated diseases among these patients were hypertension; 38 (64.4%), ischemic heart disease; 26 (44%), diabetes mellitus; 24 (40.7%), dyslipidemia; 19 (32.2%) and renal insufficiency; 13 (22%).14765938
diabeticDeregulated Nutrient SensingBody mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea.14767863
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe degree of insulin resistance in 267 Korean non-obese (body mass index [BMI] < 25 kg/m(2)) >/= patients with type 2 diabetes mellitus was analyzed, and the factors responsible for the insulin resistance were examined.14767863
TG gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results suggest that the BMI is the most important determinant of insulin resistance, while TG and HDL-C levels might be good markers of insulin resistance in non-obese patients with type 2 diabetes mellitus in Korea.14767863
Breast CarcinomaDeregulated Nutrient SensingEvaluation of the synergistic effect of insulin resistance and insulin-like growth factors on the risk of breast carcinoma.14770423
Breast CarcinomaDeregulated Nutrient SensingThe results of the current study suggest that insulin resistance and IGFs may synergistically increase the risk of breast carcinoma.14770423
methyldopa, DyslipidemiasDeregulated Nutrient SensingThere was a highly significant, direct association of indicators of dyslipidemia such as increasing HDL/LDL quotient and decreasing HDL with the severity of AMD.14872268
Precocious pubarche, Dyslipidemias, HyperandrogenismDeregulated Nutrient SensingPremature pubarche, hyper-insulinism, dyslipidemia, and hyperandrogenism, and some combinations of these, can be associated with reduced fetal growth.14960029
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was a significant association between increasing severity of ED and the presence of diabetes, hypertension, dyslipidemia, smoking, increased BMI, increased values of EDV, decreased values of PSV, RI and rigidometer (P<0.001 for each).14963466
No metabolic abnormalities, Premature coronary artery atherosclerosisDeregulated Nutrient SensingMetabolic abnormalities related to insulin resistance in patients with premature coronary atherosclerosis appear to be important mediators of major plasma oxidative damage.14966465
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingValidation of capillary glucose measurements to detect glucose intolerance or type 2 diabetes mellitus in the general population.14967156
Dyslipidemias, diabeticDeregulated Nutrient SensingThe effect of glycemic control in type 2 diabetic patients with diabetes-related dyslipidemia.14968220
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, diabetic, AtherosclerosisDeregulated Nutrient SensingThe glycemic control in type 2 diabetes significantly improves diabetic related dyslipidemia, and would be expected to reduce the risk of atherosclerosis.14968220
Cardiovascular DiseasesDeregulated Nutrient SensingThe EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I.14968294
Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is thought to be a key predictor for the development of Type 2 diabetes mellitus and cardiovascular disease (CVD), a leading cause of morbidity and premature mortality in Europe.14968294
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingDevelopment of Type 2 diabetes, dyslipidaemia, obesity, hypertension and cardiovascular events are additional endpoints.14968294
Lipolysis, Hypermetabolism, No metabolic abnormalities, Glucose Intolerance (disease)Deregulated Nutrient SensingMany endocrinological and metabolic abnormalities are observed, like hypermetabolism, glucose intolerance, increased proteolysis and lipolysis.14969155
Breast CarcinomaDeregulated Nutrient SensingBecause insulin resistance and high blood leptin levels are associated with breast cancer, losing weight to improve these parameters may reduce the risk of recurrence.14981223
Diabetes MellitusDeregulated Nutrient SensingThis study tested whether relations between insulin resistance and beta-cell function differ between current smokers, former smokers and non-smokers, and if having diabetes modifies smoking-related effects.14984456
diabeticDeregulated Nutrient SensingInsulin resistance was for normoglycaemic persons highest for current smokers, and for diabetic persons lowest for current smokers (P=0.021).14984456
Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingHyperglycaemia and insulin resistance are common in severely burned patients, even if they have not previously had diabetes.14987787
HyperglycemiaDeregulated Nutrient SensingRecent studies suggest that hyperglycaemia and insulin resistance are harmful and that correcting blood glucose to normal levels with insulin might improve the prognosis significantly.14987787
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes.14988285
ObesityDeregulated Nutrient SensingInsulin resistance and obesity may be the earliest manifestations of IRS in children with a parental history of the syndrome.14988301
Coronary Artery Disease, AtherosclerosisDeregulated Nutrient SensingInsulin sensitivity, insulinemia, and coronary artery disease: the Insulin Resistance Atherosclerosis Study.14988302
Hypertension, CTCAE, Endothelial dysfunction, cell wall thickeningDeregulated Nutrient SensingClose association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension.15001196
Hypertensive (finding), Endothelial dysfunctionDeregulated Nutrient SensingEndothelial dysfunction and insulin resistance were observed in hypertensive subjects and were associated with carotid wall thickening.15001196
Endothelial dysfunctionDeregulated Nutrient SensingOur findings suggest that endothelial dysfunction and early structural vascular changes were related to insulin resistance.15001196
Malignant neoplasm of endometriumDeregulated Nutrient SensingAdiponectin, an adipocyte-secreted hormone, is closely and inversely associated with insulin resistance and was recently found to be inversely and independently associated with endometrial cancer.15001594
Breast Carcinoma, ObesityDeregulated Nutrient SensingBecause insulin resistance in the setting of obesity has also been associated with the development of breast cancer, we have hypothesized that decreased adiponectin levels might underlie the association between breast cancer and obesity/insulin resistance.15001594
Glucose Metabolism Disorders, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance underlies most glucose disorders in adults and is associated with an increased risk of cardiovascular disease.15010644
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingEighty-nine per cent of patients had hypertension, 68% had dyslipidaemia, 32% were diabetic and 38% were previous smokers.15012697
Dyslipidemias, Nephrotic SyndromeDeregulated Nutrient SensingThe combined dyslipidaemia that accompanies the nephrotic syndrome increases the cardiovascular risk and appears to worsen long-term renal function.15012735
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThis study supports the potential role of insulin resistance in the development of poor clinical outcomes in patients with NAFLD.15017611
Coronary heart diseaseDeregulated Nutrient SensingTemperature at birth, coronary heart disease, and insulin resistance: cross sectional analyses of the British women's heart and health study.15020510
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingCold outdoor temperature at birth is associated with increased coronary heart disease, insulin resistance, dyslipidaemia, and poor lung function.15020510
Beta-cell dysfunctionDeregulated Nutrient SensingWe sought to evaluate the association between insulin resistance (IR), beta-cell dysfunction, and HCV among orthotopic liver transplant (OLT) recipients.15021833
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingClinical practice guidelines for managing dyslipidemias in kidney transplant patients: a report from the Managing Dyslipidemias in Chronic Kidney Disease Work Group of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative.15027968
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingEvidence from the general population indicates that treatment of dyslipidemias reduces CVD, and evidence in kidney transplant patients suggests that judicious treatment can be safe and effective in improving dyslipidemias.15027968
Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemias are very common in CKD and in transplant patients.15027968
ObesityDeregulated Nutrient SensingResistin is a recently discovered signal molecule, which could help elucidation of the pathophysiology of the insulin resistance and its correlation with obesity.15034607
Insulin resistance syndrome, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe proportions of 15 : 0 and 17 : 0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P<0.0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD.15035691
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPharmacist intervention for dyslipidemia appears to have a greater impact in patients with diabetes.15040652
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingEven though dietary intervention resulted in reductions in body mass index (21.0+/- 1.2 vs. 20.1 +/- 1.1 kg/m(2), P<0.01), it did not change dyslipidemia present in the offspring of hypertensive individuals.15042250
Atherosclerosis, Dyslipidemias, VAD I protocol, Data types - Address, HypogonadismDeregulated Nutrient SensingOur results indicate that VaD is associated with atherogenic dyslipidemia, in particular, small dense LDL and carotid atherosclerosis, whereas AD is associated with hyposomatomedinemia and hypogonadism rather than atherosclerosis.15045695
Lipodystrophy, Hyperglycemia, Dyslipidemias, SteatohepatitisDeregulated Nutrient SensingLeptin, an adipocyte hormone, when replaced in patients with lipodystrophy, improves insulin resistance, hyperglycemia, dyslipidemia, and hepatic steatosis.15045701
AtherosclerosisDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study (IRAS) Family Study recruited extended pedigrees of Hispanic descent from San Antonio, TX (SA) and San Luis Valley, CO (SLV).15047638
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThese findings highlight the importance of risk factors, such as high blood pressure and dyslipidaemia, in increasing CVD risk in those with diabetes.15049931
Atherosclerosis, Dais (plant), Dyslipidemias, diabetic, Coronary Artery DiseaseDeregulated Nutrient SensingThe Diabetes Atherosclerosis Intervention Study (DAIS) examined the effects of fenofibrate or placebo on the progression of coronary artery disease (CAD) in 418 type 2 diabetic subjects with dyslipidemia.15050487
RestenosisDeregulated Nutrient SensingOur findings suggest that insulin resistance measured by the homeostasis model assessment predicts restenosis after coronary stent placement in nondiabetic patients.15050499
Weight GainDeregulated Nutrient SensingHowever, their influence on weight gain, insulin resistance and other cardiovascular risk factors, as well as possible differences in obese and lean subjects, have not been fully evaluated.15057672
Weight Gain, ObesityDeregulated Nutrient SensingWeight gain was inversely related to age (beta= - 0.125, R = 0.38, p = 0.046), and insulin resistance was related to obesity at baseline (beta = 0.85, R = 0.46, p = 0.02).15057672
Hyperphagia, Obesity, Hypothalamic structureDeregulated Nutrient SensingSimilarly, patients with hypothalamic damage may develop central obesity, insulin resistance, and hyperphagia.15057893
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingThe majority of patients developed elevated glucose levels and dyslipidemia by time of diagnosis of NAFLD.15057893
Weight Gain, Dyslipidemias, Pituitary Diseases, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn conclusion, patients with hypothalamic and/or pituitary disease are at risk of excessive weight gain, impaired glucose tolerance, and dyslipidemia with subsequent development of NAFLD.15057893
HIV-Associated Lipodystrophy Syndrome, Fatty infiltrationDeregulated Nutrient SensingImprovement of fat redistribution, insulin resistance and hepatic fatty infiltration in HIV-associated lipodystrophy syndrome by pioglitazone: a case report.15061300
Inflammation, Coronary heart diseaseDeregulated Nutrient SensingThe extinction of those birth cohorts would result in a relative increase in cases coming from a 2nd subpopulation, which was characterized by insulin resistance and chronic expression of low-grade inflammation markers and was comparatively less vulnerable to die acutely from coronary heart disease.15061621
Hypertension, CTCAE, Albuminuria, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThe results demonstrate on the one hand, very high indices of cardiovascular risk (smoking, hypertension, dyslipidaemia and albuminuria) and on the other, good quality primary health care providing good detection and follow up management of type 2 diabetic patients.15063599
Carotid Atherosclerosis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAfter adjusting for age, smoking habits, consumption of alcohol, and the presence of diabetes mellitus and dyslipidemia, female subjects with the T allele of T43839A had more severe carotid atherosclerosis compared to individuals with the A allele.15064106
Colorectal CarcinomaDeregulated Nutrient SensingWe used the concentration of plasma C-peptide (an indicator of insulin production) to determine whether insulin and insulin resistance are associated with the risk of developing colorectal cancer.15069117
Colorectal CarcinomaDeregulated Nutrient SensingElevated insulin production, as reflected by elevated concentrations of plasma C-peptide, may predict the risk of developing colorectal cancer, independently of BMI, factors related to insulin resistance, or levels of IGF-I and IGFBP-3.15069117
Rabson-Mendenhall SyndromeDeregulated Nutrient SensingEfficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome.15070911
HIV-Associated Lipodystrophy SyndromeDeregulated Nutrient SensingRecombinant methionyl human leptin (r-metHuLeptin) therapy has shown clear efficacy in the treatment of severe insulin resistance associated with lipodystrophy syndromes and low leptin levels.15070911
Rabson-Mendenhall SyndromeDeregulated Nutrient SensingWe treated two siblings with Rabson-Mendenhall syndrome (severe insulin resistance and presumed insulin receptor mutations).15070911
Acanthosis Nigricans, Diabetes MellitusDeregulated Nutrient SensingThe brother and sister, aged 13 and 11 yr, respectively, had severe acanthosis nigricans, insulin resistance, and diabetes.15070911
Liver damageDeregulated Nutrient Sensing(2) Prolonged excessive insulin/IGF signaling accelerates cellular damage in cerebral neurons.15082091
Hyperinsulinism, Dyslipidemias, Coronary Arteriosclerosis, Benign prostatic hypertrophy, Diabetes Mellitus, Obesity, Hyperuricemia, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingPrevious studies have shown that non-insulin-dependent diabetes mellitus (NIDDM), hypertension, atherosclerotic disease manifestations, tallness, obesity, dyslipidaemia, hyperuricaemia, hyperinsulinaemia and high alanine aminotransferase (ALAT) levels are risk factors for development of benign prostatic hyperplasia (BPH).15083641
Dyslipidemias, Hyperinsulinism, Prostate carcinoma, Hyperuricemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe results of the present study suggest that the prostate gland volume, the BPH growth rate, hypertension, obesity, dyslipidaemia, hyperuricaemia, hyperinsulinaemia and high ALAT levels are risk factors for the development of clinical prostate cancer.15083641
ObesityDeregulated Nutrient SensingUric acid nephrolithiasis, a condition associated with a low urinary pH, has been linked to obesity and insulin resistance.15086484
ObesityDeregulated Nutrient SensingThe results confirm the previously proposed scheme that obesity may sometimes cause uric acid nephrolithiasis by producing excessively acid urine due to insulin resistance.15086484
Polycystic Ovary SyndromeDeregulated Nutrient SensingFlutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome.15087595
Hypertension, CTCAE, Dysglycemia, Dyslipidemias, ObesityDeregulated Nutrient SensingThe MS is defined as the clustering of three or more of the cardiovascular risk factors of dysglycemia, hypertension, dyslipidemia, and obesity.15093872
Diabetes MellitusDeregulated Nutrient SensingFasting insulin levels and insulin resistance increased at baseline in all subjects with diabetes and decreased during OAAM supplementation.15094102
Left Ventricular HypertrophyDeregulated Nutrient SensingThe SV/PP ratio was related to main components of the insulin resistance syndrome, concentric LVH and a low E/A ratio.15097228
HIV InfectionsDeregulated Nutrient SensingThe level of interleukin-18 (IL-18) is elevated in patients with HIV infection as well as in people with insulin resistance (IR).15097301
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThere are significant associations of lipid profiles with hemostatic factors, the directions of which suggest novel pathways by which dyslipidemia may contribute to coronary heart disease.15099276
diabeticDeregulated Nutrient SensingHowever, a small subset of these patients develops postoperative insulin resistance regardless of their preoperative diabetic status.15103177
HyperglycemiaDeregulated Nutrient SensingTen patients (3%) had postoperative hyperglycemia (serum glucose > or =250 mg/dl or 13.9 mmol/l) due to insulin resistance.15103177
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia was detected in 80%, insulin resistance in 92%.15108431
DyslipidemiasDeregulated Nutrient SensingThus, the P143L polymorphism may play a role in causing decreased HDL-C levels, leading to increased risk of dyslipidemia and CAD in Chinese.15110745
Weight decreased, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOrlistat leads to improved glycemic control in obese type 2 diabetic patients, which is attributed to decreased insulin resistance associated with weight loss.15111524
Weight decreased, diabeticDeregulated Nutrient SensingThe results of this study suggest that apart from decreasing insulin resistance as a result of weight loss, orlistat may increase postprandial GLP-1 levels, thereby enhancing the insulin secretory response to the meal and blunting the postprandial rise in glucose in type 2 diabetic patients.15111524
SteatohepatitisDeregulated Nutrient SensingSteatohepatitis may be the only manifestation of insulin resistance and warrants further evaluation.15112913
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingVeterans with IHD were more likely to have dyslipidemia (81 vs. 53%), were equally likely to be treated (54 vs. 50%), and were more likely to have optimal LDL levels (30 vs. 16%) compared with veterans without IHD, all P values <0.01.15113780
Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingComparative analysis was performed between the cases and controls regarding dyslipidemia, BMI, hypertension, diabetes, and ischemic heart disease after age adjustment with logistic regression.15114275
Diabetes MellitusDeregulated Nutrient SensingParallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes.15114470
Hypertensive (finding)Deregulated Nutrient SensingComparison of effects of exercise and diuretic on left ventricular geometry, mass, and insulin resistance in older hypertensive adults.15117727
Increased insulin levelDeregulated Nutrient SensingExercise training reduced glucose-stimulated hyperinsulinemia (before: 13.65 +/- 2.6 vs. 9.84 +/- 1.5 mU.ml(-1).min; P = 0.04) and insulin resistance.15117727
Hypertensive (finding)Deregulated Nutrient SensingUnlike hydrochlorothiazide, exercise training can improve insulin resistance and aerobic capacity in older hypertensive people.15117727
TG geneDeregulated Nutrient SensingInsulin resistance is often associated with increased triglyceride (TG) and decreased HDL-cholesterol (HDL-C) concentrations and increased small LDL particles.15117857
AURKAIP1 gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe studied the effect of pioglitazone, a thiazolidinedione that reduces insulin resistance, on the AIP of patients with type 2 diabetes.15117857
Non-Functioning Adrenal Cortex Adenoma, Cushing Syndrome, Glucose Intolerance (disease), Obesity, Adrenal Gland Hyperfunction, Hypertension, CTCAEDeregulated Nutrient SensingImprovement of hypercortisolemia even in a moderate case of Cushing's syndrome not only ameliorates hypertension, obesity and glucose intolerance, but also restores the accompanying dysfunctions of anterior pituitary, suggesting the clinical importance of early discovery and treatment of functioning adrenocortical incidentalomas.15118271
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance has been proposed as the initial step in the cascade toward type 2 diabetes mellitus.15120209
Hyperactive behavior, Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disordersDeregulated Nutrient SensingWe hypothesize that neurovascular interactions, in particular arterial elongation, causes compression of the right lateral medulla, triggering a state of autonomic dysfunction including hyperactivity of pancreatic endocrine function, and predisposes to insulin resistance and the development of type 2 diabetes.15120209
Hyperandrogenemia, Hyperlipidemia, HIV, Polycystic Ovary SyndromeDeregulated Nutrient SensingHuman immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome.15121620
Hypertension, CTCAE, Dyslipidemias, Lupus Erythematosus, SystemicDeregulated Nutrient SensingFrequencies of risk factors among the SLE patients compared to controls were hypertension (30% vs 24%), smoking (23% vs 24%), and dyslipidemia (17.7% vs 17%).15124249
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe risk factors found to be most strongly associated with presence of angiographically-detected CAD in the population studied were diabetes mellitus, dyslipidaemia, age and male gender.15125091
MicroalbuminuriaDeregulated Nutrient SensingAccordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance.15126010
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe did not consider screening targeted to persons with dyslipidemia, and we used studies of people whose diabetes was detected clinically to estimate screening benefits.15126252
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingA transition of T to C at nucleotide position 16189 in the hypervariable D-loop region of mitochondrial DNA (mtDNA) has attracted research interest for its probable correlation with increasing insulin resistance and development of diabetes mellitus (DM) in adult life.15126308
Cerebrovascular accident, Pathology, Cardiovascular DiseasesDeregulated Nutrient SensingTaken together, we suggest that the mtDNA 16189 variant is a predisposing genetic factor for the development of insulin resistance and may be related to various phenotypic expressions in adult life such as development of DM and vascular pathologies involved in stroke and cardiovascular diseases.15126308
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingSubclinical hypothyroidism (sHT) is associated with dyslipidemia and enhanced cardiovascular risk.15126526
Ketoacidosis, Diabetes MellitusDeregulated Nutrient SensingThe recognition of diabetes mellitus type 2 as the underlying illness in some patients who present with ketoacidosis means that these patients can be specifically treated for their basic problem, which is insulin resistance.15129562
Acromegaly, Chronic diseaseDeregulated Nutrient SensingThe aim of the study was to evaluate ApN secretion in patients with acromegaly, a chronic disease associated with insulin resistance and increased cardiovascular mortality, and to correlate ApN levels with hormonal, metabolic and cardiovascular parameters.15132722
Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingMoreover, concentrations of adiponectin are reduced in individuals with obesity, insulin resistance and cardiovascular disease.15132729
Obesity, AbdominalDeregulated Nutrient SensingFasting plasma adiponectin and ghrelin levels were found to be associated with central obesity or insulin resistance.15132729
Dyslipidemias, Depression, CTCAE, ObesityDeregulated Nutrient SensingThe leading risk factors were obesity, dyslipidemia, and depression.15133378
Hyperlipidemia, Dyslipidemias, USF1 wt Allele, Premature coronary artery atherosclerosisDeregulated Nutrient SensingFamilial combined hyperlipidemia (FCHL) is the most common familial dyslipidemia, and is implicated in up to 20% of cases of premature coronary heart disease.15136067
Pituitary gland enlarged, ObesityDeregulated Nutrient SensingFamilial juvenile autoimmune hypothyroidism, pituitary enlargement, obesity, and insulin resistance.15142366
deficiency aspects, Autoimmune Thyroid Disease Pathway, ObesityDeregulated Nutrient SensingBecause of the unusual association of autoimmune thyroid disease, insulin resistance and obesity rather than insulin deficiency, we searched for possible genetic abnormalities.15142366
Autoimmune Thyroid Disease PathwayDeregulated Nutrient SensingThe HLA haplotypes did not cosegregate with autoimmune thyroid disease or insulin resistance.15142366
Pituitary gland enlarged, Obesity, Hypothyroidism, AutoimmuneDeregulated Nutrient SensingIn conclusion, the remarkably high incidence of childhood autoimmune hypothyroidism, pituitary enlargement, insulin resistance and obesity in this family is not linked to known HLA types or known gene defects.15142366
Weight GainDeregulated Nutrient SensingWeight gain over time in individuals with relative insulin resistance at baseline, as measured by QUICKI, was the greatest among those who consumed a higher percent of energy from fat.15146168
Weight GainDeregulated Nutrient SensingFurther investigation into the relationship between insulin resistance, diet, and weight gain is warranted.15146168
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn subjects with type 2 diabetes and impaired glucose tolerance, high coffee consumption (>/=5 cups day(-1)) was inversely associated with insulin resistance.15147528
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMost cases are due to the cluster of classical risk factors, such as smoking, diabetes, high blood pressure and dyslipidaemia.15147532
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIt has been suggested that dyslipidaemia, an important CHD risk factor, may be worsened by dialysis.15149883
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingWe speculate that, with repeated dialysis, dyslipidaemia may get progressively worse and further accentuate CHD risk.15149883
Glucose Intolerance (disease), Periodontal DiseasesDeregulated Nutrient SensingThe severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study.15153457
Hyperinsulinism, EpilepsyDeregulated Nutrient SensingFamilial hyperinsulinaemia associated with epilepsy and mental retardation--a syndrome of familial insulin resistance.15154952
Autosome, Hyperandrogenism, Genes, RecessiveDeregulated Nutrient SensingVariants of type A insulin resistance, characterized by female hyperandrogenism and 'acromegaloid' features, have been ascribed to genetic defects of the insulin receptor or post-receptor pathways via autosomal dominant or recessive inheritance patterns.15154952
Epilepsy, Congenital Rubella SyndromeDeregulated Nutrient SensingWhilst a variety of congenital syndromes of insulin resistance are identified by their characteristic clinical phenotypes, an association with epilepsy and mental retardation has not previously been reported.15154952
Acanthosis Nigricans, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe eldest has features of severe insulin resistance with dyslipidaemia, acanthosis nigricans, 'acromegaloid features' and diabetes requiring high dose insulin therapy in combination with a glitazone.15154952
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe frequency of smoking, hypertension, and dyslipidaemia was similar in the two groups, but plasma homocysteine was higher in patients with PAPS (mean (SD) 11.9 (6.2) v 8.2 (3.4) micromol/l, p = 0.037).15155372
Weight GainDeregulated Nutrient SensingAssociations between lower birth weight and insulin resistance may be dependent on rapid weight gain during the early postnatal years.15156313
Hypoglycemia, Reactive hypoglycemiaDeregulated Nutrient SensingThe findings demonstrate the coexistence of severe postprandial hypoglycemia, insulin resistance, and impaired insulin clearance and suggest that hypoglycemia should be considered as a phenotype linked to heterozygote mutations in the insulin receptor gene.15161766
Ventricular hypertrophyDeregulated Nutrient SensingCandesartan, an angiotensin II receptor blocker, improves left ventricular hypertrophy and insulin resistance.15164328
Left Ventricular HypertrophyDeregulated Nutrient SensingAngiotensin II receptor blockers (ARB) have been reported to regress LVH and improve insulin resistance.15164328
Left Ventricular HypertrophyDeregulated Nutrient SensingWe tested the hypothesis that candesartan, an ARB, could regress LVH, in association with improvement of insulin resistance in EH patients.15164328
Left Ventricular HypertrophyDeregulated Nutrient SensingOur findings suggest that pharmacological blockade of angiotensin II receptors by candesartan could improve LVH in never-treated EH patients, which may relate to the improvement of insulin resistance.15164328
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMarkers of insulin resistance are often apparent in nondiabetic relatives of subjects with type 2 diabetes.15166304
Diabetes Mellitus, Family history, diabeticDeregulated Nutrient SensingWhether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known.15166304
Family historyDeregulated Nutrient SensingThere was no evidence for a stronger association of FH score with visceral fat accumulation than with subcutaneous fat or insulin resistance.15166304
Family history, Diabetes MellitusDeregulated Nutrient SensingThe absence of an association between FH score and insulin resistance/fat accumulation in San Luis Valley is consistent with the idea that the expression of transmitted diabetes genes may be suppressed in leaner, more physically active populations.15166304
Diabetes MellitusDeregulated Nutrient SensingA family with severe insulin resistance and diabetes due to a mutation in AKT2.15166380
Autosome, Diabetes MellitusDeregulated Nutrient SensingHere we describe a mutation in the gene encoding the protein kinase AKT2/PKBbeta in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus.15166380
Steatohepatitis, Glucose Intolerance (disease), Hepatotoxicity, Breast CarcinomaDeregulated Nutrient SensingTamoxifen induced hepatotoxicity in breast cancer patients with pre-existing liver steatosis: the role of glucose intolerance.15167162
Glucose Intolerance (disease), HepatotoxicityDeregulated Nutrient SensingGlucose intolerance before the beginning of tamoxifen treatment seems to be a predictor of the hepatotoxicity, unrelated to baseline BMI.15167162
Hypertension, CTCAEDeregulated Nutrient SensingBeing born small for gestational age (SGA) is associated with insulin resistance, hypertension and increased cardiovascular morbidity/mortality in adulthood.15167451
Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingSympathetic nerve hyperactivity is a well-known risk factor for cardiovascular disease mortality and is proposed to link insulin resistance with hypertension.15167451
Hypertension, CTCAE, Depression, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingMen with co-morbid medical conditions and risk factors, including cardiovascular disease, hypertension, dyslipidemia,and depression all reported higher prevalence of ED.15171225
diabeticDeregulated Nutrient SensingRelationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients.15171689
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThiazolidinedione therapy in the prevention/delay of type 2 diabetes in patients with impaired glucose tolerance and insulin resistance.15171752
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRecent studies suggest that early treatment with TZDs may prevent the progression from insulin resistance (IR) to type 2 diabetes mellitus (T2DM).15171752
DyslipidemiasDeregulated Nutrient SensingHowever, the relationship between dyslipidemia and asymptomatic chronic HBV infection is still unclear.15175824
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results suggest that isohumulones can improve insulin sensitivity in high fat diet-fed mice with insulin resistance and in patients with type 2 diabetes.15178687
Diabetes MellitusDeregulated Nutrient SensingA polymorphism in the IL-6 gene, a G-to-C substitution 176 bp upstream of the ATG translation initiation site, has been associated with diabetes prevalence and insulin resistance.15180970
Hyperlipidemia, Neurosecretory Systems, ObesityDeregulated Nutrient SensingReplacement therapy with recombinant methionyl human leptin (r-metHuLeptin) improves obesity, insulin resistance, hyperlipidemia, and neuroendocrine dysfunction associated with low-leptin states.15181040
AtherosclerosisDeregulated Nutrient SensingInsulin resistance has been implicated as an important initiating factor in coronary atherosclerosis.15187569
Coronary ArteriosclerosisDeregulated Nutrient SensingHowever, associations between insulin resistance and specific morphologic features of atherosclerotic coronary arteries remain unclear.15187569
Coronary ArteriosclerosisDeregulated Nutrient SensingWe ultrasonographically evaluated the morphologic features of atherosclerotic coronary arteries in nondiabetic patients with insulin resistance.15187569
Dyslipidemias, diabeticDeregulated Nutrient SensingTwenty Type 2 diabetic patients with dyslipidemia were treated 3 months with simvastatin (20 mg daily) and then 3 months with fenofibrate (200 mg daily) with 2 months of wash-out between the two treatments.15189781
Fatty Liver, Hypertensive (finding)Deregulated Nutrient SensingIncreased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance.15194655
Fatty Liver, Hypertensive (finding)Deregulated Nutrient SensingThe aim of the present study was to test the hypothesis that fatty liver with normal liver enzymes occurs more frequently in arterial hypertensive patients and to establish whether this condition is associated with insulin resistance.15194655
Fatty LiverDeregulated Nutrient SensingStepwise logistic regression and multivariate regression analysis were used on the combined sample to identify variables independently associated with fatty liver and insulin resistance.15194655
Hypertensive (finding)Deregulated Nutrient SensingHypertensive patients had a significantly higher prevalence of fatty liver (30.9% v 12.7%; p<0.041), higher insulin resistance (mean 2.27 (SD 1.81) v 1.56 (0.70); p = 0.022), and slightly higher body mass index (24.9 (3.0) v 24.0 (2.2); p = 0.043) than controls.15194655
Hypertension, CTCAEDeregulated Nutrient SensingMultivariate regression analysis showed insulin resistance to be predicted by alanine transaminase (p = 0.002), presence of arterial hypertension (p = 0.029), and body mass index (p = 0.048).15194655
Hypertensive (finding), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe higher prevalence of non-alcoholic fatty liver in non-obese hypertensive patients with normal liver enzymes appears to be related to increases in insulin resistance and body weight.15194655
Dyslipidemias, Atherosclerosis, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIt thus represents a candidate gene for the risk of dyslipidemia, atherosclerosis, and coronary heart disease (CHD).15199365
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingThe present study was performed to evaluate the association between the PPARalpha polymorphism L162V and the presence of dyslipidemia and/or atherosclerotic disease in patients with DM-2 in comparison with nondiabetic controls.15199365
Coronary Artery DiseaseDeregulated Nutrient Sensing[Study on correlation of insulin resistance with TCM syndrome type and activity of fibrinolytic system in patients with coronary arterial disease].15199623
Coronary Artery DiseaseDeregulated Nutrient SensingTo study the correlation of insulin resistance (IR) with TCM syndrome type and activity of fibrinolytic system in patients with coronary arterial disease (CAD).15199623
Glucose Intolerance (disease), HypertriglyceridemiaDeregulated Nutrient SensingA logistic regression analysis identified environmental toxin exposure and hypertriglyceridaemia, but not glucose intolerance or alcohol overuse as significant risk factors that deserve further investigation as possible causes of CIAP.15201191
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance did not appear to be an important mediating factor in the association between leg length and CHD.15201241
Acute myocardial infarction, DyslipidemiasDeregulated Nutrient Sensing[Statins in dyslipidemia associated with acute myocardial infarct].15202301
Endothelial dysfunction, AtherosclerosisDeregulated Nutrient SensingRecently, it was suggested that a "vascular insulin resistance" could explain this association, causing endothelial dysfunction and hence atherosclerosis.15204243
Endothelial dysfunctionDeregulated Nutrient SensingVascular insulin response is intact in non-diabetic CAD patients in spite of insulin resistance and endothelial dysfunction.15204243
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSubjects predisposed to Type 2 diabetes due to a small birth size are strongly protected from glucose intolerance by regular exercise.15207998
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingCarriers of the Arg allele did not have a higher prevalence of newly detected (OR 0.49, 95% CI 0.24-1.01) or treated (OR 0.71, 0.37-1.35) Type 2 diabetes in the first study, or a higher prevalence of glucose intolerance (OR 1.07, 0.71-1.59) in the second study.15209769
Obesity, Diabetes MellitusDeregulated Nutrient SensingPhysical health status is already reduced prior to diabetes diagnosis, perhaps because of obesity or other aspects of the insulin resistance syndrome.15209777
Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, Malignant Neoplasms, INTERCURRENT INFECTIONDeregulated Nutrient SensingSubjects had no symptoms of intercurrent infection, known diabetes, treated dyslipidaemia, a chronic inflammatory condition, liver disease or malignancy.15211367
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe subjects were matched for age, gender, body mass index and the patients with smoking habit, dyslipidaemia, and diabetes mellitus were excluded from the study.15215878
Cardiovascular morbidity, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSubjects with type 2 diabetes experience an increased cardiovascular morbidity and mortality, related to a high prevalence of hypertension, dyslipidemia, and obesity.15216449
Anxiety, CTCAE 3.0, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingOur data suggest that self-reported social anxiety is associated with two established risk factors for cardiovascular disease: dyslipidemia and increased WHR.15219655
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes.15221799
Diabetes MellitusDeregulated Nutrient SensingMutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown.15221799
Arterial Stiffness, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes.15223220
Arterial Stiffness, Stiff toe, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingShort-term aerobic exercise significantly decreased arterial stiffness in both common carotid and femoral arteries, and the reduction of stiffness was associated with improvement of insulin resistance in type 2 diabetes.15223220
Microalbuminuria, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria.15223221
Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingTo evaluate the relationship between insulin resistance and endothelial function in type 2 diabetes patients with or without microalbuminuria and to explore the pathophysiological mechanisms of the increased macrovascular risk in type 2 diabetes mellitus.15223221
Microalbuminuria, Grade A1 albuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Endothelial dysfunctionDeregulated Nutrient SensingCompared with type 2 diabetes patients with normoalbuminuria, patients with microalbuminuria had more severe insulin resistance, more prominent endothelial dysfunction, and higher plasma FFA, PAI-1, and vWF levels.15223221
Cardiac complication, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingTherefore we speculate that insulin resistance and endothelial dysfunction may act within the metabolic syndrome to increase the cardiovasular risk in this subset of patients, and improving insulin resistance and endothelial dysfunction may reduce the morbidity and mortality from macrovascular complications in type 2 diabetes patients.15223221
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThese findings suggest that both glucose intolerance and hypertension could have independent but not synergistic effects on endothelial function--reflected by albumin loss in urine.15224799
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingEthnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study.15226165
DyslipidemiasDeregulated Nutrient SensingOur findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia.15226165
GoutDeregulated Nutrient Sensing[Insulin resistance syndrome in patients with gout and its influence on formation of clinical characteristics of the disease].15230133
Cardiomyopathy, Familial IdiopathicDeregulated Nutrient SensingInsulin resistance in idiopathic dilated cardiomyopathy: a possible etiologic link.15234411
Cardiomyopathy, Familial IdiopathicDeregulated Nutrient SensingThis study was designed to quantify the prevalence of abnormal glucose tolerance and insulin resistance in patients with idiopathic dilated cardiomyopathy (IDCM).15234411
Heart failure, Ischemic cardiomyopathyDeregulated Nutrient SensingInsulin resistance is an independent risk factor for mortality in patients with heart failure (HF) and is a known risk factor for ischemic cardiomyopathy.15234411
DyslipidemiasDeregulated Nutrient SensingThe mean levels of total cholesterol, triglyceride, LDL-cholesterol, MDA and AuAb-oxLDL were decreased while HDL-cholesterol and TAS were increased significantly after lipid-lowering therapy in patients with dyslipidemia.15238825
Nonalcoholic Steatohepatitis, Hypertriglyceridemia, Diabetes Mellitus, Hepatomegaly, Lipodystrophy, HypoleucinemiaDeregulated Nutrient SensingGeneralized lipodystrophy is characterized by adipose tissue absence, hypoleptinemia, hypertriglyceridemia, insulin resistance, diabetes, hepatomegaly, and nonalcoholic steatohepatitis.15240593
Dyslipidemias, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, coronary artery disease, and dyslipidemia were significantly associated with ET-1 levels.15240968
Hyperlipidemia, HypoadiponectinemiaDeregulated Nutrient SensingIn addition to aggravation of insulin resistance and hyperlipidemia, some hypoadiponectinemia specific mechanisms may stand behind the association.15246202
Breast CarcinomaDeregulated Nutrient SensingInsulin, macronutrient intake, and physical activity: are potential indicators of insulin resistance associated with mortality from breast cancer?15247127
Hypertension, CTCAEDeregulated Nutrient SensingShort-term endurance training after coronary artery bypass grafting improves insulin resistance parameters in patients with hypertension.15247957
Coronary ArteriosclerosisDeregulated Nutrient SensingIt has been shown that short-term exercise training improves insulin resistance parameters in patients with ischaemic heart disease.15247957
Dyslipidemias, Hyperinsulinism, Diabetes Mellitus, Hyperferritinaemia, OverweightDeregulated Nutrient SensingThe majority of patients were young overweight or obese males, with dyslipidaemia (20-60%), diabetes (10.5%), hyperinsulinaemia (40%), hyperferritinaemia (35%).15248380
Non-alcoholic Fatty Liver Disease, Hyperinsulinism, Dyslipidemias, diabeticDeregulated Nutrient SensingThe typical Italian patient with non-alcoholic fatty liver disease is a young male, obese, not diabetic, with a variable incidence of dyslipidaemia and hyperinsulinaemia.15248380
ObesityDeregulated Nutrient SensingObesity and high blood pressure: a clinical phenotype for the insulin resistance syndrome in African Americans.15249791
Cardiovascular DiseasesDeregulated Nutrient SensingThe high prevalence of insulin resistance syndrome in African Americans predisposes this population to higher morbidity and mortality from cardiovascular disease.15249791
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingPrevalence of prediabetes (24.4%), diabetes (19.2%), and insulin resistance syndrome (87.2%) were highest in the obese-high BP group (p<0.001).15249791
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingEffects of simvastain combined with omega-3 fatty acids on high sensitive C-reactive protein, lipidemia, and fibrinolysis in patients with mixed dyslipidemia.15250255
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPatients with CHD and CHD risk equivalents with mixed dyslipidemia were treated with 10 or 20 mg simvastatin for 6-12 weeks.15250255
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIn CHD and CHD risk equivalent patients with mixed dyslipidemia, dyslipidemia's therapeutic effect using simvastatin and omega-3 fatty acids may result from not only the combination of lipid adjustment, but also enhancement of their own nonlipid influences.15250255
Diabetes MellitusDeregulated Nutrient SensingAlthough insulin resistance plays an important role in the development of diabetes in many ethnic populations, the differences in insulin sensitivity between NGT and IGT and between IGT and DM are small in Japanese patients.15254872
diabeticDeregulated Nutrient SensingJapanese type 2 diabetic patients are characterized by a larger decrease in insulin secretion and show less attribution of insulin resistance.15254872
Glucose Intolerance (disease)Deregulated Nutrient SensingOn the other hand, as glucose intolerance increases, insulin secretion decreases most remarkably both between NGT and IGT and between IGT and DM in Japanese patients.15254872
Coronary heart diseaseDeregulated Nutrient SensingRisk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood.15254876
Inflammation, Cardiovascular DiseasesDeregulated Nutrient SensingThis raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation.15254876
Tumor necrosis, No metabolic abnormalities, ObesityDeregulated Nutrient SensingTumor necrosis factor-alpha (TNF-alpha) seems to be increased in obese subjects, suggesting its role as a proinflammatory cytokine to insulin resistance and metabolic abnormalities in obesity.15254878
Tumor necrosis, Liver CirrhosisDeregulated Nutrient SensingIncreased serum soluble tumor necrosis factor receptor levels are associated with insulin resistance in liver cirrhosis.15254888
Liver CirrhosisDeregulated Nutrient SensingInsulin resistance is present in nearly all patients with liver cirrhosis, but its etiology remains unclear.15254888
Tumor necrosis, ObesityDeregulated Nutrient SensingRecent studies have shown that tumor necrosis factor-alpha (TNF-alpha) system is involved in the insulin resistance of human obesity.15254888
Liver CirrhosisDeregulated Nutrient SensingThis study explored whether TNF-alpha system activity was associated with insulin resistance in liver cirrhosis.15254888
Liver CirrhosisDeregulated Nutrient SensingOur study demonstrated that elevated sTNF-RII levels were associated with insulin resistance in liver cirrhosis.15254888
Glucose Intolerance (disease), Beta-cell dysfunctionDeregulated Nutrient SensingIn conclusion, the primacy of beta-cell dysfunction in the process of developing glucose intolerance was strongly suggested in the Japanese general population.15254892
Ketoacidosis, Diabetes MellitusDeregulated Nutrient SensingMain features of this form of diabetes mellitus are the severe insulin resistance and the absence of ketoacidosis.15256772
Hyperlipidemia, Premature coronary artery atherosclerosis, Dyslipidemias, USF1 wt Allele, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDecreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD).15258200
DyslipidemiasDeregulated Nutrient SensingThese dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis.15258200
DyslipidemiasDeregulated Nutrient SensingFinnish families ascertained for dyslipidemias thus suggest that 10q11, 2q31, and 20q13.32 harbor loci for HDL-C and TGs.15258200
Cardiovascular DiseasesDeregulated Nutrient SensingHigh PBF levels were associated with increased risk of cardiovascular disease and insulin resistance.15258201
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance in Japanese adolescents with type 2 diabetes mellitus.15260081
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt was revealed that insulin resistance is present not only in obese adolescents with type 2 diabetes mellitus, but also in non-obese adolescents with type 2 diabetes mellitus.15260081
DyslipidemiasDeregulated Nutrient SensingAtorvastatin improves diabetic dyslipidemia and increases lipoprotein lipase activity in vivo.15262189
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA major factor contributing to cardiovascular mortality in type 2 diabetes is dyslipidemia, characterized by low HDL cholesterol and high triglycerides, rather than elevated LDL cholesterol.15262189
DyslipidemiasDeregulated Nutrient SensingOur data demonstrate that atorvastatin induces a significant improvement of diabetic dyslipidemia and a significant increase of LPL activity.15262189
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Obesity, HyperandrogenismDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) occurs in around 10% women of reproductive age and is characterised by obesity, hyperandrogenism, insulin resistance and adverse lipid profile.15262192
ETV3 wt AlleleDeregulated Nutrient SensingElevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women.15262834
Hypertension, CTCAEDeregulated Nutrient SensingVisceral fat in hypertension: influence on insulin resistance and beta-cell function.15262911
diabeticDeregulated Nutrient SensingPreferential visceral adipose tissue (VAT) deposition has been associated with the presence of insulin resistance in obese and diabetic subjects.15262911
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and insulin resistance might increase the risk of fatty liver in the patients with type 2 diabetes.15268806
Dyslipidemias, Toxic effectDeregulated Nutrient SensingClinicians need to remain cognizant of this potential adverse event and discuss signs and symptoms of muscle toxicity with patients in order improve the benefits-to-risks of treating dyslipidemia with statins.15269925
HyperproinsulinemiaDeregulated Nutrient SensingSagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men.15277437
Cardiovascular systemDeregulated Nutrient SensingIt is clinically important to find noninvasive markers of insulin resistance and hyperproinsulinemia because they both predict cardiovascular and diabetes risk.15277437
HyperproinsulinemiaDeregulated Nutrient SensingSagittal abdominal diameter (SAD) or "supine abdominal height" is a simple anthropometric measure previously shown to predict mortality in men, but its association with insulin resistance and hyperproinsulinemia is unknown.15277437
Sandawe language, HyperproinsulinemiaDeregulated Nutrient SensingIn multiple regression analyses, including all anthropometric measures, SAD was the only independent anthropometric predictor of insulin resistance (P < 0.001) and hyperproinsulinemia (P < 0.001).15277437
Sandawe language, HyperproinsulinemiaDeregulated Nutrient SensingIn obese men, SAD seems to be a better correlate of insulin resistance and hyperproinsulinemia (i.e., cardiovascular risk) than other anthropometric measures.15277437
Inflammation, Dyslipidemias, Vascular DiseasesDeregulated Nutrient SensingDyslipidaemia, inflammation and oxidative stress are prominent risk factors that potentially cause vascular disease in haemodialysis patients.15280524
DyslipidemiasDeregulated Nutrient SensingThis randomized crossover study demonstrates a potent effect of high-flux haemodialysis on uraemic dyslipidaemia.15280524
DyslipidemiasDeregulated Nutrient SensingLow ACP1 activity/high ADA activity joint genotype was also positively associated with dyslipidemia.15281007
HirsutismDeregulated Nutrient SensingA 65-year-old woman presented with elevated testosterone levels, hirsutism and insulin resistance.15283061
HypoadiponectinemiaDeregulated Nutrient SensingUnhealthy lifestyles may cause hypoadiponectinemia and insulin resistance followed by insulin resistance syndrome, i.e.15283178
Calcification of coronary artery, SLC25A20 geneDeregulated Nutrient SensingWe examined the association of insulin resistance and MetSyn with coronary artery calcification (CAC) in 840 asymptomatic nondiabetic subjects.15289378
Cardiovascular DiseasesDeregulated Nutrient SensingThese findings support the use of biomarkers of insulin resistance in addition to NCEP MetSyn criteria in assessing cardiovascular disease risk.15289378
Coma (genus), Glucose Intolerance (disease), Diabetic KetoacidosisDeregulated Nutrient SensingThe severity of cases ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma.15291665
ObesityDeregulated Nutrient SensingAdiponectin is decreased in obesity and seems to be involved in insulin resistance.15292306
Weight decreasedDeregulated Nutrient SensingThe significant weight loss in 16 children was associated with a significant increase in adiponectin (P = 0.010) and a decrease in insulin resistance (P = 0.013), whereas there were no changes in the 26 children without significant weight loss.15292306
Weight decreasedDeregulated Nutrient SensingSignificant weight loss led to an increase in adiponectin levels and an improvement of insulin resistance.15292306
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingWe conclude that, in this population of elderly, diabetic patients undergoing rehabilitation, dietary supplementation with chromium is beneficial in moderating glucose intolerance.15296075
DyslipidemiasDeregulated Nutrient SensingExcept for cigarette smoking and slight dyslipidaemia, classical risk factors for stroke/embolism were absent.15297005
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHeritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.15298351
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim of this study was to measure the heritability estimates for metabolic traits and the features of the insulin resistance syndrome in families with an increased genetic susceptibility to Type 2 diabetes.15298351
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn families with a high risk of Type 2 diabetes, the heritability estimates for fasting glucose, pancreatic beta cell function and the features of the insulin resistance syndrome were all high.15298351
Arterial StiffnessDeregulated Nutrient SensingThe observed increasing arterial stiffness (or decreased elasticity) with increasing number of risk factors related to insulin resistance syndrome in free-living, asymptomatic young adults has important implications for prevention.15306189
Diabetes MellitusDeregulated Nutrient SensingApplication of YYHT principle in treating patients with diabetes mellitus type 2 of secondary failure to sulfonylurea agents could alleviate the peripheral resistance to insulin, inhibit TNF-alpha, and protect the vascular endothelial cells.15307693
Diabetes MellitusDeregulated Nutrient Sensing[Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines].15307695
Diabetes MellitusDeregulated Nutrient SensingSerum CRP concentrations and factors related to insulin resistance were determined in middle-aged Finnish men who participated in a population-based cohort study and were free of diabetes at baseline.15309290
Inflammation, Metabolic Syndrome X, Obesity, Diabetes MellitusDeregulated Nutrient SensingLow-grade inflammation may increase the risk of the metabolic syndrome and diabetes in middle-aged men, but some of the risk is mediated through obesity and factors related to insulin resistance.15309290
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin regulates glucose homeostasis by binding and activating the insulin receptor, and defects in insulin responses (insulin resistance) induce type 2 diabetes.15314154
Increased insulin level, Glucose Intolerance (disease), HyperglycemiaDeregulated Nutrient SensingConsequently, SH2-B-/- knockout mice developed age-dependent hyperinsulinemia, hyperglycemia, and glucose intolerance.15314154
Glucose Intolerance (disease), Hypertriglyceridemia, Obesity, Fatty Liver DiseaseDeregulated Nutrient SensingThis study confirmed the contribution of obesity, glucose intolerance, and hypertriglyceridemia to NASH development in the Japanese population.15318095
Malignant neoplasm of endometriumDeregulated Nutrient SensingInsulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer.15322863
Malignant neoplasm of endometriumDeregulated Nutrient SensingTo study the frequency of insulin resistance (IR) in endometrial cancer patients, its relation to the clinical course of the disease and DNA damage, and to evaluate possible approaches to the pharmacological correction of IR in the patients studied.15322863
Malignant neoplasm of endometrium, NeoplasmsDeregulated Nutrient SensingThe signs of insulin resistance syndrome and its association with the clinical and pathological features of the disease and DNA damage in somatic cells (micronucleus frequency in peripheral blood lymphocytes) and endometrial normal and tumor tissue (alkaline unwinding) were determined in 99 endometrial cancer patients.15322863
Increased insulin levelDeregulated Nutrient SensingOn the other hand, hyperinsulinemia and other hormonal-metabolic disturbances typical of insulin resistance syndrome do not increase the probability of DNA damage of somatic cells (according to the data of micronucleus test).15322863
NeoplasmsDeregulated Nutrient SensingThus, insulin resistance/hyperinsulinemia is associated with a more aggressive course of the disease in certain groups of the patients but--in contrast to excessive estrogenic stimulation--does not result in increased genotoxic damage in tumor and normal tissues.15322863
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of the cardiovascular disease risk factors, dyslipidemia, hypertension, and diabetes mellitus, is increased in the setting of obesity.15328940
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe incidence rates of dyslipidemia, hypertension, and diabetes mellitus do not increase with a greater degree of obesity above a body mass index of 34.99 kg/m2.15328940
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNone of the traditional cardiovascular risk factors (hypertension, diabetes mellitus, dyslipidaemia, significant family history, smoking, male gender and increased age) was predictive.15329749
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingConcomitant diabetes mellitus was present in 31%, hypertension in 58% and dyslipidaemia in 63% of patients.15329751
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe majority of patients were males in their sixth decade with underlying dyslipidaemia or hypertension.15329751
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingLeptin and dyslipidemia are risk factors for cardiovascular disease.15331885
Cardiac complication, DyslipidemiasDeregulated Nutrient SensingDyslipidemia may be a risk factor for cardiovascular complications in marasmic children in the future.15331885
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCirculating adiponecin levels are reduced in states of insulin resistance such as type 2 diabetes.15333487
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingEfficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia.15333967
Hypertensive (finding)Deregulated Nutrient SensingEffects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.15335180
Dyslipidemias, AlbuminuriaDeregulated Nutrient SensingAlbuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p<0.01).15338128
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a major cause of type 2 diabetes mellitus (T2DM).15338456
Cushing Syndrome, Depressed moodDeregulated Nutrient SensingLipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment.15349009
Diabetes MellitusDeregulated Nutrient SensingAssociation between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus.15349727
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance, estimated by homeostasis model assessment, and Type 2 diabetes were diagnosed in 803 and 635 patients respectively.15349727
Diabetes MellitusDeregulated Nutrient SensingUnivariate analysis revealed that plasma MCP-1 levels were significantly and positively correlated with WHR ( p=0.011), insulin resistance ( p=0.0097) and diabetes ( p<0.0001).15349727
Diabetes MellitusDeregulated Nutrient SensingIn multivariate analysis, the G allele retained statistical significance as a negative predictor of insulin resistance (OR=0.78, 95% CI: 0.65-0.93, p=0.0060) and diabetes (OR=0.80, 95% CI: 0.66-0.96, p=0.018).15349727
Diabetes MellitusDeregulated Nutrient SensingIn a large cohort of Caucasians, the MCP-1 G-2518 gene variant was significantly and negatively correlated with plasma MCP-1 levels and the prevalence of insulin resistance and Type 2 diabetes.15349727
Weight Gain, DyslipidemiasDeregulated Nutrient SensingIn addition, many antipsychotic drugs have been associated with weight gain and some with dyslipidaemia.15352932
Dyslipidemias, ObesityDeregulated Nutrient SensingWhen directly measured, the actual prevalence of obesity was above population norms and two-thirds of patients had a dyslipidaemia.15352932
Dyslipidemias, ObesityDeregulated Nutrient SensingObesity, dyslipidaemias and smoking in an inpatient population treated with antipsychotic drugs.15352932
Sleep-Disordered Breathing, Glucose Intolerance (disease)Deregulated Nutrient SensingClinic-based studies suggest that sleep-disordered breathing (SDB) is associated with glucose intolerance and insulin resistance.15353412
Sleep-Disordered Breathing, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus.15353412
Glucose Intolerance (disease)Deregulated Nutrient SensingSleep-related hypoxemia was also associated with glucose intolerance independently of age, gender, body mass index, and waist circumference.15353412
OverweightDeregulated Nutrient SensingPrenatal growth restriction is associated with insulin resistance but relatively increased adiponectin concentrations, provided overweight does not ensue.15355450
Diabetes MellitusDeregulated Nutrient SensingThe contributions of circulating adiponectin to the increased risks for developing insulin resistance and type-2 diabetes in formerly SGA subjects merit further studies.15355450
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined the effect of pioglitazone (PIO) on circulating adipocytokine levels to elucidate the mechanisms by which thiazolidinediones improve insulin resistance in type 2 diabetes mellitus (T2DM).15356026
Retinal Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetes.15356034
Diabetic Retinopathy, PDR geneDeregulated Nutrient SensingIn this cross-sectional, case-control study we explored the association of proliferative diabetic retinopathy (PDR) with insulin resistance (IR) in type 2 diabetics with serum creatinine less than 2.0 mg/dl.15356034
ObesityDeregulated Nutrient SensingOverexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins.15356040
ObesityDeregulated Nutrient SensingOverexpression of 11beta-HSD-1 in murine adipose tissue results in glucocorticoid receptor (GR)alpha overexpression, central obesity, and insulin resistance.15356040
ObesityDeregulated Nutrient SensingIn conclusion, expression of 11beta-HSD-1 in sc adipose tissue is increased in human acquired obesity and is closely related to accumulation of sc and intraabdominal fat and features of insulin resistance.15356040
ObesityDeregulated Nutrient SensingGlucocorticoids play an important role in the pathogenesis of obesity and insulin resistance.15356090
Failure (biologic function), Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingFailure to down-regulate 11beta-HSD1 activity in patients with diabetes may potentiate dyslipidemia, insulin resistance, and obesity.15356090
Increased insulin level, insulinomaDeregulated Nutrient SensingWe followed a case of insulinoma that caused primary hyperinsulinemia, and measured the change in visceral fat and insulin resistance before and after surgical resection of the insulinoma.15356380
Increased insulin levelDeregulated Nutrient SensingThese results suggest that hyperinsulinemia might be one of the factors that enhance visceral adiposity and insulin resistance.15356380
Hypertension, CTCAEDeregulated Nutrient SensingPrevalence of hypertension, low HDL-cholesterol, high triglycerides and insulin resistance and the prevalence of most disease outcomes increased with increasing degrees of overweight/obesity.15356666
Poor fine motor coordination, Diabetes Mellitus, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingOver 60% of the prevalence of high insulin resistance was attributable to overweight and obesity as was over a third of diabetes and hypertension, a quarter of locomotor disability and a fifth of major CVD.15356666
Microvascular Angina, DyslipidemiasDeregulated Nutrient SensingThese findings suggest that microvascular disease in the retina may result from processes distinct from dyslipidaemia.15359242
Hypertension, CTCAE, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingOur findings suggest that subclinical hypothyroidism in middle-aged women is associated with hypertension and dyslipidemia.15361814
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Annex: Prevalence of insulin resistance and its association with type 2 diabetes and other cardiovascular risk factors].15362265
Diabetes Mellitus, Arteriopathic diseaseDeregulated Nutrient SensingWe present the results of an epidemiological research undertaken in the province of Cordoba (Argentina) with the aim of studying insulin-resistance (IR) in relation to the increased risk for diabetes and its association with risk factors of arterial disease (RFAD).15362265
Hypertensive (finding), Endothelial dysfunction, Ventricular hypertrophyDeregulated Nutrient SensingPlasma ADMA appears to play a major role in endothelial dysfunction in hypertensive patients, independent of insulin resistance or left ventricular hypertrophy.15363823
Hypertensive (finding)Deregulated Nutrient SensingEffect of amlodipine-atorvastatin combination on fibrinolysis in hypertensive hypercholesterolemic patients with insulin resistance.15363826
Hypertensive (finding), Dyslipidemias, Low-Density LipoproteinsDeregulated Nutrient SensingDyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles.15363830
Coronary ArteriosclerosisDeregulated Nutrient SensingIn women, LDL particle size may mediate some of the atherogenic effects of low-HDL cholesterol-high-triglyceride dyslipidemia, but does not appear to be independently associated with the extent of coronary atherosclerosis in either sex.15363830
Hypertriglyceridemia, Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidaemia in obesity is characterized by hypertriglyceridaemia, low HDL-C levels, small, dense HDL particles and increased phospholipid transfer protein (PLTP) activity.15365582
Weight decreased, Dyslipidemias, ObesityDeregulated Nutrient SensingOur results suggest that dyslipidaemia in obesity is--at least partially--reversible by weight loss.15365582
Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease.15365613
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn men with diabetes, increased insulin resistance (homeostasis model assessment, HOMA) was associated with increased levels of haemostatic markers and dyslipidaemia.15365613
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIncreased insulin resistance among men with Type 2 diabetes is associated with increased prevalence of CHD and of activated haemostasis and dyslipidaemia.15365613
Thrombosis, Diabetes Mellitus, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingReducing insulin resistance in men with diabetes may reduce their tendency to develop thrombosis and hence CHD risk.15365613
ObesityDeregulated Nutrient SensingThe relative effects of obesity and insulin resistance on cardiovascular risk factors in nondiabetic and normotensive men.15366636
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe presence of insulin resistance was found to accentuate the risk factors for CHD, with the exception of LDL-C and Apo A-I in the obese.15366636
Coronary Restenosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingComparison of frequency of insulin resistance after coronary stenting in patients with type 2 diabetes mellitus with versus without coronary restenosis.15374787
Restenosis, diabeticDeregulated Nutrient SensingThe large incidence of restenosis after coronary angioplasty in diabetic patients renders this procedure less effective than in nondiabetics, and insulin resistance could be a relevant cause of restenosis in such patients.15374787
Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disordersDeregulated Nutrient SensingMicroalbuminuria, cardiovascular autonomic dysfunction, and insulin resistance in patients with type 2 diabetes mellitus.15375795
Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disordersDeregulated Nutrient SensingWe tested the hypothesis that the presence of microalbuminuria would correlate with cardiovascular autonomic dysfunction and insulin resistance in type 2 diabetic patients.15375795
DyslipidemiasDeregulated Nutrient SensingThe effect of statins and fibrates on interferon-gamma and interleukin-2 release in patients with primary type II dyslipidemia.15380456
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingOxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients.15381345
Left Ventricular HypertrophyDeregulated Nutrient SensingThe levels of fasting triglyceride and insulin, as well as insulin resistance index (IRI), were higher in the LVH group than in the control group.15447860
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCirculating C-peptide concentrations are associated with insulin resistance and the development of type 2 diabetes.15447918
Diabetes MellitusDeregulated Nutrient SensingFurthermore, our study suggests that these nutrients play divergent roles in the development of insulin resistance and type 2 diabetes.15447918
Injury of liver, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingElevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study.15448093
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingOur objective was to investigate the associations of elevated AST and ALT with incident type 2 diabetes among 906 participants in the Insulin Resistance Atherosclerosis Study who were nondiabetic at baseline.15448093
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingAmong coronary risk factors, 63% had hypertension, 27% had diabetes, 52% had dyslipidemia, 31% smoked and 21% had a family history of atherosclerosis.15449548
beta ThalassemiaDeregulated Nutrient SensingAbnormal glucose tolerance is common in multiply transfused beta-thalassemia major patients, which could be attributed to progressive and early loss of beta-cell mass, along with persistent insulin resistance.15450007
Executive dysfunctionDeregulated Nutrient SensingInsulin resistance and executive dysfunction in older persons.15450050
Presenile dementia, Demographics Domain, Executive dysfunction, Diabetes MellitusDeregulated Nutrient SensingTo evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia.15450050
Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe frequency of diabetes, hypertension, dyslipidemia, previous myocardial infarction were common, yet not different between groups (P=NS).15450555
ObesityDeregulated Nutrient SensingAdiponectin and resistin, two recently discovered adipocyte-secreted hormones, may link obesity with insulin resistance and/or metabolic and cardiovascular risk factors.15451915
Rheumatoid Arthritis, SpondylitisDeregulated Nutrient SensingEffects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis.15458960
Tumor necrosisDeregulated Nutrient SensingTumour necrosis factor alpha (TNFalpha) may be an important mediator of insulin resistance.15458960
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is independently associated with postprandial alterations of triglyceride-rich lipoproteins in type 2 diabetes mellitus.15458975
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo evaluate the role of insulin resistance in development of postprandial dyslipidemia in type 2 diabetic patients in an experimental setting in which these patients were compared with nondiabetic subjects at similar glucose and insulin blood levels.15458975
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, HyperglycemiaDeregulated Nutrient SensingInsulin resistance is also associated with postprandial lipoprotein abnormalities in type 2 diabetes after acute correction for hyperglycemia and hyperinsulinemia.15458975
InflammationDeregulated Nutrient SensingThe cluster of MS components based on insulin resistance may cause low-grade inflammation.15459460
Communicable Diseases, HyperglycemiaDeregulated Nutrient SensingTo evaluate whether hyperglycaemia in the first 48 h after infrainguinal vascular surgery is a risk factor for post-operative infection, independent from factors associated with insulin resistance and surgical stress.15465374
Arterial StiffnessDeregulated Nutrient SensingImpact of an exercise program on arterial stiffness and insulin resistance in hemodialysis patients.15466276
Arterial StiffnessDeregulated Nutrient SensingArterial stiffness and insulin resistance are independent risk factors for cardiovascular mortality in this population.15466276
Glucose Intolerance (disease), Overweight, diabeticDeregulated Nutrient SensingExercise reduces insulin resistance and glucose intolerance in sedentary, overweight individuals and diabetic patients.15466276
Arterial StiffnessDeregulated Nutrient SensingThe purpose of this study was to determine the impact of an exercise program on arterial stiffness and insulin resistance in a group of patients on hemodialysis.15466276
Arterial StiffnessDeregulated Nutrient SensingThe effect of exercise training on arterial stiffness and insulin resistance in 11 patients who were on chronic hemodialysis was evaluated.15466276
Arterial StiffnessDeregulated Nutrient SensingThese findings suggest that 3 mo of aerobic exercise training improves arterial stiffness, an independent risk factor for cardiovascular mortality in patients who are on hemodialysis, and has no impact on insulin resistance.15466276
Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingBoth Mg deficit and obesity may independently lead to a higher risk for insulin resistance and cardiovascular disease.15466953
Glucose Intolerance (disease), Duodenal Somatostatin-Producing Neuroendocrine TumorDeregulated Nutrient SensingLarge duodenal somatostatinoma in the third portion associated with severe glucose intolerance.15468970
Inflammation, HIV Infections, Hypertriglyceridemia, Dyslipidemias, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAlthough it is likely that the greatest proportion of CHD risk in the HIV+ subjects may be accounted for by pathological conditions linked to HIV infection in interaction with mediating processes such as inflammation, central obesity, and dyslipidemia, which was greater than in controls, it appears that PI medications may exacerbate oxidative stress and hypertriglyceridemia to enhance this risk.15470277
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes as well as glucose intolerance was greater in men and in the regions of the Center and South of Italy.15471153
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension was the most common risk factor detected in all patients, followed by smoking (83.3%), dyslipidemia (83.3%) and diabetes (33.3%).15471296
ETV3 wt AlleleDeregulated Nutrient SensingWe conclude that antioxidative activity of small, dense HDL subfractions of altered chemical composition is impaired in MetS and associated with elevated oxidative stress and insulin resistance.15472192
Hyperglycemia, HyperlipidemiaDeregulated Nutrient SensingIt has been proposed that the hexosamine pathway acts as a nutrient-sensing pathway, protecting the cell against abundant fuel supply, and that accumulation of hexosamines represents a biochemical mechanism by which hyperglycemia and hyperlipidemia induce insulin resistance.15472217
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe hypothesized that if an increased flux through the hexosamine pathway caused insulin resistance in humans, the hexosamine levels should be increased in adipose and/or muscle tissue in insulin-resistant subjects, such as patients with type 2 diabetes and obese individuals.15472217
Lipodystrophy, Dyslipidemias, Hearing problemDeregulated Nutrient SensingReasons for switching were treatment simplification (45%), lipodystrophy (24%), renal problems (23%), and dyslipidemia (8%).15472856
Heart Diseases, Dyslipidemias, Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingLower frequencies have been presented for cardiac diseases (27.0%), Diabetes Mellitus (19.9%), and dyslipidemia (15.6%) as risk factors for ischemic stroke in old people of both genders and all ages after 60.15476081
Thrombosis, Dyslipidemias, Behcet Syndrome, ThrombophiliaDeregulated Nutrient SensingTo determine the prevalence of the most common thrombophilias and dyslipidaemia in patients with Behcet's disease with and without thrombosis.15479893
Thrombosis, Dyslipidemias, Behcet SyndromeDeregulated Nutrient SensingBlood samples from 107 patients with Behcet's disease who had or did not have thrombosis were analysed for factor V Leiden, prothrombin G20210A polymorphism, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, factor VIII level, homocysteine and C reactive protein concentrations, dyslipidaemia, and plasma glucosylceramide.15479893
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingHowever, dyslipidaemia, predominantly hypertriglyceridaemia, might be a risk factor.15479893
InflammationDeregulated Nutrient SensingAn inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance.15486052
Kaposi Sarcoma, Dyslipidemias, Malignant NeoplasmsDeregulated Nutrient SensingSeventy-seven percent of the patients smoked cigarettes, 57% had dyslipidemia, and 43% had a malignancy (most commonly Kaposi sarcoma).15486847
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingResults were then compared to those of 30 control subjects and 16 unrelated patients with primary hypercholesterolemia (Type IIA dyslipidemia) before and after atorvastatin therapy.15488884
SchizophreniaDeregulated Nutrient SensingInsulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients.15491236
Inflammation, ThrombosisDeregulated Nutrient SensingIn conclusion, apoB is more closely associated with central adiposity, insulin resistance, thrombosis, and inflammation than NHDLC.15492304
Hyperandrogenemia, Prostate Cancer Outcomes Study, Endocrine System Diseases, Obesity, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is a common endocrinopathy with symptoms such as obesity, insulin resistance and hyperandrogenemia.15497495
Hypertension, CTCAE, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingHypertension and dyslipidemia are risk factors for atherosclerosis and occur together more often than expected by chance.15498972
Toxic effectDeregulated Nutrient SensingA deleterious consequence of increased mitochondrial efficiency would be a reduced utilization of energy substrates, especially fatty acids, leading to intracellular triglyceride accumulation and lipotoxicity, thus contributing to the onset of skeletal muscle insulin resistance.15504966
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn the United States, obesity is a major clinical and public health problem causing diabetes, dyslipidemia, and hypertension, as well as increasing cardiovascular and total mortality.15505128
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingMultiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normal-weight group.15505132
Inflammation, ObesityDeregulated Nutrient SensingEffects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery.15507518
Inflammation, Endothelial dysfunction, ObesityDeregulated Nutrient SensingMetabolic alterations such as insulin resistance are thought to underlie the endothelial dysfunction and low grade inflammation found in morbid obesity.15507518
Inflammation, Glucose Intolerance (disease), Acute myocardial infarction, Diabetes MellitusDeregulated Nutrient SensingInflammation, insulin resistance, and glucose intolerance in acute myocardial infarction patients without a previous diagnosis of diabetes mellitus.15509644
Overweight, Diabetes MellitusDeregulated Nutrient SensingThe diabetes was associated with overweight, overage and higher insulin, HbA1C and insulin resistance levels.15511355
Metabolic Syndrome X, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD) is considered to be the liver component of the metabolic syndrome and is frequently associated with obesity, dyslipidemia and type II diabetes mellitus (NIDDM).15513385
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia, with elevated triglycerides and/or hypercholesterolemia, was now present in 65 patients (81%).15513385
Diabetes MellitusDeregulated Nutrient SensingWe therefore hypothesized that an impaired meal-related vascular response might be an in vivo marker of vascular insulin resistance, related to the presence of diabetes and/or higher age.15513964
diabeticDeregulated Nutrient SensingTherefore, meal ingestion results in impaired vasodilator responses in older nondiabetic and diabetic adults, related to aging rather than insulin resistance.15513964
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe results suggest that hyperinsulinemia/insulin resistance may be responsible for low progesterone levels during the luteal phase in PCOS.15517078
Acromegaly, Atherosclerosis, Somatotropin deficiencyDeregulated Nutrient SensingAtherosclerosis and insulin resistance are common complications of adult growth hormone deficiency (GHD) and acromegaly.15519253
Acromegaly, Somatotropin deficiencyDeregulated Nutrient SensingAdiponectin levels are similar in patients with GHD and healthy controls, whereas in patients with acromegaly, insulin resistance appears to be not closely related to adiponectin levels compared with BMI.15519253
Acromegaly, Somatotropin deficiencyDeregulated Nutrient SensingThe different relationship between adiponectin and QUICKI observed in the adult GHD and acromegaly groups presumably reflects differences in the mechanisms of insulin resistance under states of GH deficiency or excess.15519253
AtherosclerosisDeregulated Nutrient SensingWe measured F2-isoPM in urine of 52 participants of the Insulin Resistance Atherosclerosis Study by both methods.15519902
Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNearly half of the study sample (46%) was aware of the fact that a healthy lifestyle may contribute to stroke prevention, but only 24% mentioned that medical follow-up and control of hypertension, dyslipidemia and diabetes mellitus reduce the risk of stroke.15521679
ObesityDeregulated Nutrient SensingResistin, a peptide hormone, has been discussed controversially as a missing link between obesity and insulin resistance.15523596
Kidney Failure, ChronicDeregulated Nutrient SensingPatients with end-stage renal disease (ESRD) are known to have insulin resistance.15523598
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIt is considered that the determination of apolipoproteins may be useful not only for the detection of risk factors for atherosclerosis, but also for a better insight concerning the mechanisms involved in the development of an atherogenic dyslipidemia.15523947
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia, elevated LDL cholesterol and reduced nocturnal blood pressure dipping denote lacunar strokes occurring during nighttime.15525295
DyslipidemiasDeregulated Nutrient SensingThe mean low-density lipoprotein (LDL) cholesterol level was significantly higher amongst patients with nocturnal strokes (133.3 +/- 35.2 mg/dl vs. 115.5 +/- 39.8 mg/dl; P = 0.04), as well as the proportion of patients with any dyslipidemia (94% vs. 77.8%; P = 0.047).15525295
Dyslipidemias, Stroke, LacunarDeregulated Nutrient SensingDyslipidemia, especially elevated LDL cholesterol is more prevalent in nocturnal lacunar strokes especially when combined with a reduced nocturnal dipping of blood pressure.15525295
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingA study of 48 patients with angina pectoris carried out, in which the structural lipids of the hair were analyzed and correlated with the manifestations of angina and the potential incidence of dyslipidemia.15526542
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingThe analysis of the hair has been shown to be also useful in detecting latent dyslipidemia associated with angina pectoris.15526542
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingAlso, through the analysis of hair, large scale epidemiologic studies can be carried out on the association between dyslipidemia and angina pectoris.15526542
Cerebrovascular Disorders, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingEarlier studies have shown that the fatty acid binding protein 2 (FABP2) T54 allele is associated with dyslipidemia, which in turn correlates with the incidence of cerebrovascular disease (CVD).15527447
Beta-cell dysfunctionDeregulated Nutrient SensingOral anti-diabetic combinations that address insulin resistance and beta-cell dysfunction (e.g.15529514
Autoimmune Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTwo of the three insulin resistant children had positive GADA and one of them had positive ICA, therefore showing "mixed" features of both type 1 (autoimmunity) and type 2 diabetes (insulin resistance).15529623
Coronary Artery Disease, Turner SyndromeDeregulated Nutrient SensingIn addition, insulin resistance may be present in up to 50% of women with Turner syndrome and an atherogenic lipid profile (increased cholesterol, triglycerides) favors the development of coronary artery disease.15529627
Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt AlleleDeregulated Nutrient SensingNIDDM: new once-daily intervention for type 2 diabetes mellitus: Diaprel MR. Pharmacological treatment of hyperglycemia should address to both abnormalities in T2DM treatment, that is reduction of insulin resistance and restoration of normal insulin secretion.15529633
Hirsutism, HypertriglyceridemiaDeregulated Nutrient SensingThe severity of hypertriglyceridemia and hirsutism in females was related to that of insulin resistance.15531479
HyperglycemiaDeregulated Nutrient SensingCritical illness is associated with insulin resistance and hyperglycemia.15531485
Hypoadiponectinemia, AcromegalyDeregulated Nutrient SensingWe hypothesized that hypoadiponectinemia was present in acromegaly, as in other conditions with increased insulin resistance and cardiovascular risk.15531496
Hypoadiponectinemia, AcromegalyDeregulated Nutrient SensingHypoadiponectinemia, reversible with GH-lowering therapies, may contribute to the increased insulin resistance and cardiovascular risk in patients with acromegaly.15531496
ObesityDeregulated Nutrient SensingAdiponectin, a novel adipocytokine with insulin sensitizing properties, is inversely related to obesity and insulin resistance in adults.15531504
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBoth the point at which sensitivity equaled specificity and the shortest distance in the receiver operating characteristic curves for hypertension, dyslipidemia, diabetes, or >/=2 of these risk factors suggested a BMI cutoff of 24 and a waist circumference cutoff of 80 cm for both men and women.15531658
Burn Specimen Source CodesDeregulated Nutrient SensingThis decrease may be the result of marked insulin resistance, as suggested by the elevated insulin to glucose ratio in burn patients.15534457
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingThese subjects fell into three distinct lipid patterns: atherogenic dyslipidemia, isolated hypercholesterolemia, and mixed dyslipidemia.15539961
Menstrual abnormalities, Arthralgia, Diabetes Mellitus, Glucose Intolerance (disease), Headache, Erectile dysfunction, Hypertension, CTCAEDeregulated Nutrient SensingPatients were reviewed for the presence of headaches, arthralgias, hypertension, menstrual abnormalities, impotence, glucose intolerance or diabetes.15542931
Obesity, diabeticDeregulated Nutrient SensingSince obesity affects insulin resistance, the diabetic patients were also divided into two groups: those with a BMI of <23, and those with a BMI of >23.15543562
DyslipidemiasDeregulated Nutrient SensingOf the vascular risk factors, both the smoking (7.5 +/-4.7 ng/mL) and dyslipidemia groups (7.4+/-4.4 ng/mL) showed significantly increased plasma TGF-beta1 levels, compared to the non-smokers (5.5+/-2.8 ng/mL), and those without dyslipidemia (4.8+/-2.8 ng/mL) (P<0.05).15546028
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDebate surrounds the relative importance of impaired beta-cell secretory function versus insulin resistance in type 2 diabetes.15551159
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingNon-HDL cholesterol is now recommended as an index of risk associated with combined dyslipidemia, and it has also been found useful in predicting coronary heart disease (CHD) risk in patients with diabetes.15552218
Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing), therapy of dyslipidemias, antihypertensive therapy and diabetes control.15552230
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia in patients with angiographically confirmed coronary artery disease--an opportunity for improvement.15553311
Steatohepatitis, ObesityDeregulated Nutrient SensingOur data suggest that hepatic steatosis can increase insulin resistance independently of obesity.15553597
Demographics Domain, Hypercholesterolemia, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalences of diabetes mellitus (DM) (24.7%, 33.6%, 41.1% and 44.7%, respectively) and impaired glucose tolerance (IGT) (5.9%, 8.0%, 9.3% and 11.0%, respectively) steadily increased, whereas dyslipidemia (high total cholesterolemia, high triglyceridemia, or low high-density lipoproteinemia) and hypertension remained unchanged.15557709
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingIn 1993, DM and dyslipidemia were significant predictors for MVD (Odds Ratio: 2.72 and 2.68, respectively).15557709
DyslipidemiasDeregulated Nutrient SensingIn conclusion, fenofibrate effectively improves atherogenic dyslipidemia by reducing remnants and small LDL, as well as by increasing HDL particles.15557710
DiastoleDeregulated Nutrient SensingInsulin resistance (P = .01), serum triglycerides (P = .01), C-reactive protein (P = .03), and blood pressure (P = .07 for both systolic and diastolic) improved more with the low-glycemic load diet.15562127
Diabetes MellitusDeregulated Nutrient SensingThese results show an inverse association between vitamin D status and diabetes, possibly involving insulin resistance, in non-Hispanic whites and Mexican Americans.15562190
Bipolar Disorder, Diabetes MellitusDeregulated Nutrient SensingDepressive symptoms, insulin resistance, and risk of diabetes in women at midlife.15562197
InflammationDeregulated Nutrient SensingClinical and epidemiological data indicate that inflammation may be associated with insulin resistance.15562214
Chronic infectious disease, HypoalphalipoproteinemiasDeregulated Nutrient SensingAlthough a possible confounding variable could be a degree of insulin resistance within the group of patients with low HDL-C levels, our results indicate that C-reactive protein levels are increased in subjects with nonselected hypoalphalipoproteinemia and that chronic infections do not appear to mediate this relationship.15562377
HyperglycemiaDeregulated Nutrient SensingInsulin resistance after the androgen-deprivation therapy might lead to marked hyperglycemia in these patients.15562380
Weight decreasedDeregulated Nutrient SensingIn addition, weight reduction was achieved in patients with insulin resistance during this study.15563963
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?15565368
diabeticDeregulated Nutrient SensingPrevious studies have suggested that the high bone density often observed in type 2 diabetic patients may be explained by insulin resistance.15565368
FBXO8 gene, Alcoholic Intoxication, ChronicDeregulated Nutrient SensingThe high-risk group was also associated with other non-lipid factors such as overweight -54% (BMI > 25Kg/m2), glucose intolerance-55% (FBS > 6.1 mmol/L), and alcoholism (55%).15565928
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome XDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD), a common entity in the general population, has been shown to be linked with insulin resistance and metabolic syndrome.15566509
IGA GlomerulonephritisDeregulated Nutrient SensingThese same factors are central in the metabolic or insulin resistance syndrome and may have a pathogenetic role in the progression of IgAN.15572382
Milk (body substance)Deregulated Nutrient SensingHigh intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys.15578035
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient SensingThey develop fasting hyperglycemia and glucose intolerance and are at risk for greater insulin resistance than mice lacking GLUT4 in only one tissue.15578099
Diabetes MellitusDeregulated Nutrient SensingGenetic determinants limiting this "metabolic flexibility" may contribute to insulin resistance and type 2 diabetes in humans.15578099
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is the central defect in the development of type 2 diabetes, preceding its onset by 10-20 years.15579187
AtherosclerosisDeregulated Nutrient SensingCorrelations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations.15579191
AtherosclerosisDeregulated Nutrient SensingThe aim of this study was to determine the correlations of plasma adiponectin concentration with insulin resistance and atherosclerosis.15579191
AtherosclerosisDeregulated Nutrient SensingThe results suggest that adiponectin plays a role in lipid metabolism and correlates with atherosclerosis either directly or through insulin resistance.15579191
Fibrosis Assessment, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingLeptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease.15582127
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHuman plasma leptin and several indicators of insulin resistance were measured in 88 NAFLD patients and matched controls.15582127
Fibrosis Assessment, Diabetes MellitusDeregulated Nutrient SensingBy multivariate analysis, the significant association between leptin and fibrosis was abolished (adjusted P = 0.3) when controlling for confounders including age, gender, BMI, diabetes and insulin resistance.15582127
Acquired (qualifier value)Deregulated Nutrient SensingAcquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins.15585588
Intra-Abdominal Fat, ObesityDeregulated Nutrient SensingWe conclude that acquired obesity is associated with increases in intra-abdominal and liver fat and insulin resistance, independent of genetic factors.15585588
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingTwenty-five patients with stable angina and dyslipidemia undergoing clinical treatment were studied prospectively.15587571
DyslipidemiasDeregulated Nutrient SensingEffects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.15587767
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThe sustained, favourable effects of pioglitazone on important components of diabetic dyslipidaemia may contribute to reduced cardiovascular disease risk, among patients with type 2 diabetes.15587767
HyperinsulinismDeregulated Nutrient SensingProbably as a result of hyperinsulinaemia associated with insulin resistance.15587841
Tumor necrosis, Hypertensive (finding), diabeticDeregulated Nutrient SensingEffect of amlodipine on insulin resistance & tumor necrosis factor-alpha levels in hypertensive obese type 2 diabetic patients.15591634
Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingTumour necrosis factor-alpha (TNF-alpha) has been suggested to play a key role in insulin resistance (IR) in obesity and may contribute to the development of type 2 diabetes mellitus.15591634
Fatty degenerationDeregulated Nutrient SensingIn nondiabetic subjects, a progressive (P < 0.05) increase in mean homeostasis model of insulin resistance was recorded from the group without steatosis to the groups with mild/moderate and severe steatosis.15598693
ObesityDeregulated Nutrient SensingObesity per se increased the levels of the risk factors, but central adiposity contributed to a greater extent to adverse high-density lipoprotein-cholesterol, triglyceride, and insulin resistance levels.15601976
Heart Failure, DiastolicDeregulated Nutrient SensingInsulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure.15604330
Heart Failure, Diastolic, Inflammation, dihydrofolic acid bindingDeregulated Nutrient SensingTo evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF).15604330
dihydrofolic acid bindingDeregulated Nutrient SensingInsulin resistance and inflammatory activation are present in older patients with SHF and DHF.15604330
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe hypothesized that the AIG(glu) decreases in Type 2 diabetes mellitus as a consequence of insulin resistance, whereas it remains intact in Type 1 diabetes.15606692
Skeletal muscle structure, diabeticDeregulated Nutrient SensingBecause no changes in muscle blood flow were detected, insulin resistance appears to be the main cause for the observed decreased AIG(glu) in skeletal muscle in Type 2 diabetic patients.15606692
Presenile dementia, Diabetes MellitusDeregulated Nutrient SensingDiabetes, insulin resistance, and dementia among HIV-1-infected patients.15608521
Asthma, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia resolved or improved in 87% and asthma was cured or improved in 89% of those affected.15608802
Diabetes MellitusDeregulated Nutrient SensingThe overall age-standardised prevalence of diabetes (both known and newly diagnosed) was 10.6% and the age-standardised prevalence of insulin resistance was 37.0%.15608803
Diabetes MellitusDeregulated Nutrient SensingDiabetes is a common disorder among this population, but insulin resistance is even more prevalent, especially among young age groups.15608803
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis is considerable cause for concern given that insulin resistance is believed to be the underlying cause of most cases of type 2 diabetes mellitus, and is confirmed by these data to be associated with a high degree of cardiovascular risk.15608803
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingMen with type III hyperlipidemia had the highest calorie intake and those with type IV dyslipidemia had the highest alcohol intake.15611703
AtherosclerosisDeregulated Nutrient SensingDietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population.15613260
Heart Diseases, Diabetes MellitusDeregulated Nutrient SensingThe present study identified highly consistent associations of distinct dietary patterns with measures of insulin resistance and adiposity, which are risk factors for diabetes and heart disease.15613260
Three Vessel Coronary Disease, Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients were predominantly men (70%), commonly presented with two- or three-vessel disease, and frequently had hypertension, a history of myocardial infarction and dyslipidemia.15614334
Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingAccumulating evidence suggests that insulin resistance in patients with diabetes and the metabolic syndrome may impair endothelial function, uncovering a proinflammatory, proatherosclerotic vascular phenotype.15614340
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease.15617368
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe found that 57.8% of all patients had hypertension or dyslipidemia; 30.7% had both.15617368
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSixteen percent of all patients had diabetes mellitus, and 66.3% of these patients had concomitant hypertension and dyslipidemia.15617368
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingWe hypothesized that insulin resistance would be associated with nondipping in patients who did not have frank diabetes mellitus or hypertension.15619409
Increased insulin level, Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingThe polycystic ovary syndrome (PCOS) is characterized by insulin resistance with compensatory hyperinsulinemia.15623819
Hyperandrogenemia, Prostate Cancer Outcomes Study, Acanthosis NigricansDeregulated Nutrient SensingWomen with PCOS and the MBS differ from their counterparts lacking the MBS in terms of increased hyperandrogenemia, lower serum SHBG, and higher prevalence of acanthosis nigricans, all features that may reflect more severe insulin resistance.15623819
TG geneDeregulated Nutrient SensingA second component, related to the insulin resistance syndrome, may be principally genetic and associated with the high TG, low HDL, and LDL phenotype B observed in these Mexican children.15623835
Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was a high prevalence of risk factors for ischemic heart disease (cigarette smoking, diabetes mellitus, hypertension and dyslipidemia) (65% had one or more risk factors) with no relation to educational level.15626273
Sleep Apnea, ObstructiveDeregulated Nutrient SensingInsulin resistance is a typical feature of the obstructive sleep apnea syndrome (OSAS).15627868
Weight decreasedDeregulated Nutrient SensingDynamic strength training improves insulin sensitivity in men with insulin resistance independently on weight loss or increase in aerobic capacity.15628572
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance was observed in 31 treated patients (38%), of whom 22 (27%) had impaired glucose tolerance and six (7%) had diabetes mellitus.15628647
Abnormal circulating valine concentration, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was the predominant metabolic abnormality in the treated group, observed in 58 patients (72%).15628647
diabeticDeregulated Nutrient SensingB. Ludvik et al., have recently shown the effect of Caiapo (Ipomoea batatas L.) on reducing fasting blood glucose and insulin resistance in type-2 diabetic patients.15630271
Turban, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of type 2 diabetes and dyslipidemia in turban aboriginal populations is higher than that of their rural counterparts.15631206
Metabolic Diseases, Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingThe degree of abnormalities in body fat depots and the degree of tissue insulin resistance were in parallel with the number of other metabolic diseases (hypertension and dyslipidemia) associated in type 2 diabetic patients.15631769
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension is often accompanied by other cardiovascular risk factors such as dyslipidemia, smoking, diabetes and increased body mass index (BMI).15633617
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes.15634339
Diabetes Mellitus, Non-Insulin-Dependent, Traumatic injuryDeregulated Nutrient SensingInsulin resistance is a cardinal feature of type 2 diabetes and also a consequence of trauma such as surgery.15634339
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe insulin resistance directly after surgery and cell isolation was different from insulin resistance of type 2 diabetes; adipocytes from patients with type 2 diabetes remained insulin resistant after overnight incubation.15634339
Kidney Failure, Chronic, Glucose Intolerance (disease)Deregulated Nutrient SensingWe propose that the elevated HbA1c level may be due to the repetitive exposure of patients' RBCs to the high glucose level in dialysate (200 mg/dl) or may reflect true glucose intolerance in non-diabetic patients with ESRD.15636425
AtherosclerosisDeregulated Nutrient SensingAdiponectin is a new anti-inflammatory protein secreted exclusively by adipocytes and plays a protective role against insulin resistance and atherosclerosis.15638879
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Obesity, Chronic disease, Cerebrovascular Disorders, Hypertension, CTCAEDeregulated Nutrient SensingDiabetes, coronary hearth disease, hypertension, cerebrovascular disease and dyslipidemia are chronic diseases associated with obesity.15641468
Steatohepatitis, ObesityDeregulated Nutrient SensingThe excess risk associated with central obesity might be related to insulin resistance and hepatic steatosis.15645407
Acromegaly, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study was performed to test the effect of neurosurgery in acromegaly (sharing at baseline insulin resistance but not increased visceral fat with type 2 diabetes) on insulin sensitivity, adiponectin concentrations and ALT activity.15653112
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingOdds ratios of 1 kg increase in leg LTM were only significant for dyslipidaemia in men and hypercholesterolaemia in women (both 0.93).15656878
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)Deregulated Nutrient SensingInsulin resistance index and other clinical data were compared in sex-, age- and duration-matched MODY3 and MODYX patients.15657605
Maturity Onset Diabetes of the Young PathwayDeregulated Nutrient SensingA majority of Chinese MODY patients are due to defects in unknown genes and appear to be characterized by insulin resistance.15657605
diabeticDeregulated Nutrient SensingInsulin resistance decreased by 21.9% in the sibutramine-treated diabetic patients and by 38.5% in the nondiabetic group.15660196
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingAdipose tissue distribution (visceral vs subcutaneous) has been shown to be an important predictor of insulin resistance, diabetes and cardiovascular disease, independent of body mass index.15672110
Eye AbnormalitiesDeregulated Nutrient SensingLeprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene.15672252
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe development of insulin resistance is a critical step in the pathogenesis of type 2 diabetes.15673056
Ventricular hypertrophy, Hypertrophic CardiomyopathyDeregulated Nutrient SensingBecause mutations in the gene for AMP-activated protein kinase gamma2 (PRKAG2) cause an accumulation of cardiac glycogen and left ventricular hypertrophy that mimics hypertrophic cardiomyopathy, we hypothesized that hypertrophic cardiomyopathy might also be clinically misdiagnosed in patients with other mutations in genes regulating glycogen metabolism.15673802
Dyslipidemias, atherosclerotic, diabeticDeregulated Nutrient SensingAdiponectin, predominantly synthesized in the adipose tissue, seems to have substantial anti-inflammatory properties and to be a major modulator of insulin resistance and dyslipidemia, mechanisms that are associated with an increased atherosclerotic risk in diabetic patients.15677512
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingRecently, insulin resistance (IR) was proposed as a primary pathogenic mechanism in non-alcoholic steatohepatitis (NASH).15682659
Bipolar DisorderDeregulated Nutrient SensingInsulin resistance and depressive symptoms in middle aged men: findings from the Caerphilly prospective cohort study.15684022
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance in patients with chronic kidney disease.15685504
Chronic Kidney DiseasesDeregulated Nutrient SensingIt has been reported that insulin resistance appears at an earlier stage of chronic kidney disease (CKD).15685504
No metabolic abnormalities, Acidosis, Chronic Kidney DiseasesDeregulated Nutrient SensingHowever, few data are available concerning what factors of metabolic abnormalities, such as apolipoprotein (Apo) profile or acidosis, might be associated with insulin resistance in patients with CKD.15685504
Decline in functional statusDeregulated Nutrient SensingWe found that insulin resistance correlated linearly with decline in renal function.15685504
Chronic Kidney DiseasesDeregulated Nutrient SensingIndependent variables related to insulin resistance were bicarbonate and Apo A-1/B levels in patients with CKD.15685504
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes.15688209
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe degree of association varied in relation to the glycaemic status: no insulin resistance: r(2)=6.5% (p<0.001), insulin resistance without type 2 diabetes: r(2)=21.0% (p<0.001), type 2 diabetes: r(2)=25.4 (p<0.001).15688209
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingDonor-related as well as nonimmunologic factors, such as hypertension and dyslipidemia, are associated with increased risk for renal allograft damage progression.15689401
ObesityDeregulated Nutrient SensingWe conclude that increases in LpB:C-III in childhood and adolescence are associated with insulin resistance and obesity supporting the need for prevention programs.15690311
Tumor necrosisDeregulated Nutrient SensingTumor necrosis factor alpha has a key role in insulin resistance.15690319
Hyperglycemia, Tumor necrosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMetformin is able to reverse insulin resistance and hyperglycemia in high-risk subjects for type 2 diabetes mellitus independently of the effects on tumor necrosis factor alpha system activity.15690319
TG gene, Dyslipidemias, ObesityDeregulated Nutrient SensingInsulin resistance and obesity are associated with a dyslipidemia composed of high levels of triglycerides (TG), low levels of high-density lipoprotein cholesterol (HDL-C), and no change in level of low-density lipoprotein cholesterol (LDL-C).15690322
AtherosclerosisDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study is a multicenter cohort study of middle-aged men and women.15690322
Weight Gain, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingTo determine the frequency and risk factors of NAFLD and chronological ordering between NAFLD, weight gain, and features of insulin resistance, a historical cohort study was conducted in a Japanese workplace.15690483
Communicable Diseases, Injury of liver, Hepatitis BDeregulated Nutrient SensingA cohort free of previous liver injury, alcohol consumption of more than 140 g/wk, and hepatitis B or C infection (529 of 1537 subjects), and a subcohort of 287 subjects free of insulin resistance-related features were identified.15690483
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingControl of hypertension was achieved in 34.5%, dyslipidemia in 50.3% and diabetes in 35.5%.15691431
Proteinuria, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFactors independently associated with a bad integral control were: diabetes (OR = 0.33; 95%CI: 0.23-0.47), dyslipidemia (OR = 0.34; 95%CI: 0.24-0.48), proteinuria (OR = 0.36; 95%CI: 0.18-0.71).15691431
Proteinuria, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes, dyslipidemia or proteinuria predisposed to a worse control and the number of complementary tests performed to the patients was related to a better control.15691431
Metabolic Syndrome XDeregulated Nutrient SensingThe findings suggest that metabolic syndrome and insulin resistance are not synonymous anthropometrically, metabolically, hemodynamically, or hormonally in patients with high-normal BP.15691610
Hypertensive (finding)Deregulated Nutrient SensingAdiponectin, insulin resistance, and left ventricular structure in dipper and nondipper essential hypertensive patients.15691614
Hypertensive (finding)Deregulated Nutrient SensingIn the absence of major cardiovascular risk factors, nondipper essential hypertensive patients show more prominent insulin resistance and lower adiponectin compared to dippers.15691614
Refractory anemias, Cardiovascular morbidity, Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingCardiovascular morbidity and mortality appear to be enhanced in rheumatoid arthritis (RA), which might be due to an increased prevalence of cardiovascular risk factors such as dyslipidemia.15693084
AHSG protein, humanDeregulated Nutrient SensingFetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance.15698447
Kidney DiseasesDeregulated Nutrient SensingThe reasons for this association in the presence of nephropathy are unclear, but may be secondary to proatherogenic insulin resistance.15698447
DyslipidemiasDeregulated Nutrient SensingFollowing the educational program, the use of aspirin, clopidogrel, or warfarin increased from 69 to 99%, the use of beta- blockers increased from 57 to 98%, the use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers increased from 41 to 97%, and the use of lipid-lowering drugs in patients with dyslipidemia increased from 54 to 98% in patients without contraindications to these drugs.15705260
Hypertriglyceridemia, ObesityDeregulated Nutrient SensingThe development of this complication is strongly associated with three clinical risk factors; specifically, insulin resistance, central obesity, and hypertriglyceridemia, however a genetic predisposition to THS has yet to be investigated.15706422
Lupus Erythematosus, Discoid, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingOur findings suggest that patients with cutaneous discoid lupus erythematosus have an increased risk of atherosclerosis due to the marked dyslipidemia associated with the disease.15708553
Glucose Intolerance (disease), Obesity, AbdominalDeregulated Nutrient SensingRecent studies show that African-Caribbean women who have a high level of internalized racism (INR) are at increased risk for abdominal obesity and glucose intolerance.15712783
Dyslipidemias, ObesityDeregulated Nutrient SensingIn women, increases of obesity indexes by quartile analyses showed linear increases of odds ratios for dyslipidemia (p values <0.01 by trend test).15716594
Dyslipidemias, ObesityDeregulated Nutrient SensingAs a simple and non-invasive method for a detection of obesity and dyslipidemia, anthropometric measurements could be efficiently used in clinical and epidemiologic fields.15716594
Proteinuria, Hypertension, CTCAE, Dyslipidemias, HypoalbuminemiaDeregulated Nutrient SensingThe patients presented with hypertension, significant proteinuria, hypoalbuminemia, and dyslipidemia.15717645
Hyperglycemia, DyslipidemiasDeregulated Nutrient Sensing[Activated factor XII in patients with hyperglycaemia and dyslipidaemia].15717806
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere are increased levels of FXIIa in patients with dyslipidaemia and also elevated levels of FXIIa have been reported in patients with diabetes mellitus.15717806
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingPlasma leptin concentration in patients with Type 2 diabetes: relationship to cardiovascular disease risk factors and insulin resistance.15717875
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is common in Type 2 diabetes which, in turn, is associated with a markedly increased risk of cardiovascular disease.15717879
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingAmong patients with Type 2 diabetes, insulin resistance is not a risk factor for cardiovascular disease.15717879
Myotonic Dystrophy, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingOne of the clinical features of myotonic dystrophy is insulin resistance with non-obese diabetes mellitus (DM).15717887
Myotonic DystrophyDeregulated Nutrient SensingRecently, the mechanism of insulin resistance in patients with myotonic dystrophy was revealed.15717887
Increased insulin level, Myotonic Dystrophy, Demographics DomainDeregulated Nutrient SensingIt is important to choose the optimal treatment for DM in myotonic dystrophy, because the patients have hyperinsulinemia caused by specific mechanism and could not reduce the insulin resistance.15717887
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingEthnic, gender, and age-related differences in treatment and control of dyslipidemia in hypertensive patients.15720044
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingThese data were confirmed after the stratification of patients into younger (<65 y) and older (>/=65 y) or into subjects with and without a family history of dyslipidemia or vascular diseases.15721016
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThis dyslipidemia increased the risk of coronary disease by 50% over 10 years.15721096
DyslipidemiasDeregulated Nutrient SensingThere are increasing reports of dyslipidemia and cardiovascular events associated with highly active antiretroviral therapy.15721096
Dyslipidemias, HIVDeregulated Nutrient SensingAccordingly, minimizing dyslipidemia associated with highly active antiretroviral therapy may preserve life expectancy among adults who have the human immunodeficiency virus.15721096
Fibrosis, Liver, Hepatitis CDeregulated Nutrient SensingInsulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients.15726693
Steatohepatitis, Fibrosis Assessment, Hepatitis CDeregulated Nutrient SensingWe measured the levels of insulin resistance (as HOMA score) and leptin in 221 non-diabetic chronic hepatitis C patients, to assess their impact on liver steatosis and fibrosis, relative to other factors, using a multivariable logistic regression.15726693
Fatty degenerationDeregulated Nutrient SensingLevels of insulin resistance were not correlated with the presence of steatosis.15726693
Hepatitis C, fibrogenesisDeregulated Nutrient SensingThus, insulin resistance (but not leptin) may play a role in fibrogenesis in chronic hepatitis C patients infected with genotype non-3.15726693
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSex disparity in the management of dyslipidemia among patients with type 2 diabetes mellitus in a managed care organization.15726854
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTo determine whether there were sex-related differences in the management of dyslipidemia among managed care enrollees with diabetes mellitus.15726854
Arterial Stiffness, Hypertensive (finding)Deregulated Nutrient SensingArterial stiffness is related to insulin resistance in nondiabetic hypertensive older adults.15728211
Arterial Stiffness, HyperglycemiaDeregulated Nutrient SensingBoth insulin resistance and hyperglycemia may contribute to the development of arterial stiffness.15728211
Arterial Stiffness, Hypertensive (finding)Deregulated Nutrient SensingOlder nondiabetic hypertensive adults were recruited to test the following hypotheses: (1) insulin resistance is associated with arterial stiffness, and (2) this relationship is independent of glucose tolerance status.15728211
Arterial Stiffness, Hypertensive (finding)Deregulated Nutrient SensingThese results suggest that in hypertensive, nondiabetic, older adults, insulin resistance is associated with arterial stiffness independent of glucose tolerance status.15728211
Increased insulin level, ObesityDeregulated Nutrient SensingThe role of ghrelin in childhood obesity, a state associated with hyperinsulinism and insulin resistance, is not fully understood.15728212
ObesityDeregulated Nutrient SensingAlterations in ghrelin suppression in OW children may be yet another manifestation of the insulin resistance of obesity.15728212
Diabetes MellitusDeregulated Nutrient SensingWe identified a mitochondrial intramembrane protease, known as presenilins-associated rhomboid-like protein (PSARL) that is associated with insulin resistance and type 2 diabetes.15729572
Communicable Diseases, Chlamydia, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient Sensing[Chlamydia pneumoniae infection increases the risk of coronary artery disease in the patients with dyslipidemia].15730813
Communicable Diseases, Chlamydia, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingTo investigates the role of chlamydia pneumoniae (CP) infection in the development of coronary artery disease (CAD) in the patients with dyslipidemia, and to examine the gender related differences in this role.15730813
DyslipidemiasDeregulated Nutrient SensingCP infection increases the risk of CAD only in patients with dyslipidemia, and this increase was greater in women than in men.15730813
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia.15731489
Obesity, AbdominalDeregulated Nutrient SensingContribution of abdominal visceral obesity and insulin resistance to the cardiovascular risk profile of postmenopausal women.15734855
Pre-EclampsiaDeregulated Nutrient SensingCompared to women with uncomplicated pregnancies, those with a history of preeclampsia had significantly elevated levels of fasting serum triglycerides, insulin and glucose, and a higher fasting insulin resistance index, suggesting that women with prior preeclampsia were relatively insulin resistant.15735370
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCorrelation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes.15736103
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe studied the correlation between the adiponectin-leptin (A/L) ratio and parameters of insulin resistance in 220 Japanese patients with type 2 diabetes (138 men and 82 women).15736103
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results suggested that the A/L ratio was effective in relevance as a parameter of insulin resistance to adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than HOMA-R as the FPG level elevated, in patients with type 2 diabetes.15736103
diabeticDeregulated Nutrient SensingRed wine consumption improves insulin resistance but not endothelial function in type 2 diabetic patients.15736107
diabeticDeregulated Nutrient SensingTo determine whether red wine improves insulin resistance in diabetic patients and to explore the relation between insulin sensitivity and endothelial function, we studied vascular reactivity and insulin-mediated glucose uptake in 9 type 2 diabetic patients before and after 2 weeks of red wine consumption (360 mL/d, wine-treated diabetics) and 8 type 2 diabetic patients who did not consume wine (control diabetics).15736107
diabeticDeregulated Nutrient SensingIn conclusion, red wine consumption for 2 weeks markedly attenuates insulin-resistance in type 2 diabetic patients, without affecting vascular reactivity and nitric oxide production.15736107
diabeticDeregulated Nutrient SensingSoluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients.15736116
diabeticDeregulated Nutrient SensingFrom these results, it can be concluded that in conjunction with serum triglycerides and serum leptin, serum E-selectin is another important independent factor associated with insulin resistance in nonobese Japanese type 2 diabetic patients.15736116
Hypertensive diseaseDeregulated Nutrient SensingIn conclusion, cellular insulin resistance in EBV-transformed lymphoblasts is associated with young Japanese subjects with HBP.15736115
Primary malignant neoplasm, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe Trp64Arg polymorphism in the beta3AR gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes; little is known about its possible association with cancer.15743038
Kidney DiseasesDeregulated Nutrient SensingRenal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study.15743998
Renal Insufficiency, Chronic Kidney DiseasesDeregulated Nutrient SensingIn patients with chronic kidney diseases, a syndrome of insulin resistance is present even in the earliest stage of renal dysfunction, and several components of this syndrome are associated with CV events.15743998
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus.15744804
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance, which implies impairment of insulin signaling in the target tissues, is a common cause of type 2 diabetes.15744804
diabeticDeregulated Nutrient SensingIn conclusion, the plasma adiponectin concentrations were closely related to the insulin resistance parameters in Korean type 2 diabetic patients.15744804
Peripheral Vascular Diseases, HypoglycemiaDeregulated Nutrient SensingUnfortunately, first-and second-generation beta-blockers are associated with the worsening of insulin resistance, deterioration of glycemic control, peripheral vasoconstriction, potentially worsening peripheral vascular disease, and more frequent and severe hypoglycemia.15745836
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingIschemic non-embolic stroke in the elderly is associated with dyslipidemia and several predictor metabolic factors, which could be substantially modified by lifestyle changes and therapeutic intervention.15749186
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe 64Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension.15751274
Dyslipidemias, Peripheral Arterial Diseases, Diabetes Mellitus, Infarction, Chronic Obstructive Airway Disease, Depression, CTCAE, Cerebrovascular Disorders, Hypertensive (finding), Kidney FailureDeregulated Nutrient SensingIn the univariate analysis, hypertensive subjects presented more frequently non-Q-wave infarction and ST segment depression than did normotensive subjects, even if hypertensive subjects more frequently had diabetes, dyslipidemia, renal failure, peripheral artery disease, cerebrovascular disease, and chronic obstructive pulmonary disease (P < .01 for all).15752942
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and insulin resistance are common features of Type 2 Diabetes.15754730
Diabetes, Autoimmune, diabeticDeregulated Nutrient SensingMain positive change observed in patients received only diabetic diet, where was a decrease of insulin resistance and in patients with latent autoimmune diabetes (type LADA), where was a increase insulin secretion and decrease of daily dose of insulin requiring.15754961
Obesity, AtherosclerosisDeregulated Nutrient SensingAdiponectin, an adipocyte-derived protein, seems to be a link between obesity, insulin resistance, and atherosclerosis.15758248
Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingSuch a relationship has been considered by others concerning the well-described association between diabetes and carcinoma of the pancreas, in which the underlying pathophysiologic process seems to be insulin resistance.15760789
Dyslipidemias, Hepatitis CDeregulated Nutrient SensingBaseline cholesterol > 200 mg/dL and triglycerides > 150 mg/dL were independent risk factors for dyslipidaemia, while hepatitis C coinfection appeared to be protective.15761071
Dyslipidemias, Coronary Artery Disease, emotional dependency, Diabetes MellitusDeregulated Nutrient SensingNo association, however, was found in group A between MPV and age, gender, duration of diabetes, insulin dependency, BMI, HbA1c, coronary artery disease or dyslipidaemia.15763888
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance plays an important role in the pathogenesis of coronary artery disease (CAD).15765163
Hepatitis C, ChronicDeregulated Nutrient SensingInsulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients.15765399
Hepatitis C, ChronicDeregulated Nutrient SensingWe evaluated the effect of insulin resistance and viral factors on sustained virological response in patients with chronic hepatitis C treated with peginterferon plus ribavirin.15765399
Fibrosis Assessment, Hepatitis CDeregulated Nutrient SensingInsulin resistance, fibrosis, and genotype are independent predictors of the response to antiviral therapy in chronic hepatitis C patients treated with peginterferon plus ribavirin.15765399
Microalbuminuria, Dyslipidemias, Electrocardiogram: left ventricle hypertrophy (finding), Cardiovascular DiseasesDeregulated Nutrient SensingIn men, furthermore, mortality was predicted by previous cardiovascular disease, left ventricular hypertrophy and microalbuminuria, whilst in women mortality was predicted by high blood pressure and dyslipidemia.15765637
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingHypertension, dyslipidemia, and diabetes mellitus were all present in 43.3% of men and 29.1% of women with obesity class 3.15767503
Increased insulin level, Angina Pectoris, VariantDeregulated Nutrient SensingInsulin resistance relates to acetylcholine-induced microvascular vasoconstriction in a patient with vasospastic angina: potential implication of causalities between hyperinsulinemia and coronary microcirculation failure.15772782
Chest PainDeregulated Nutrient SensingMicrovascular vasoconstriction must be considered when a patient with insulin resistance presents with chest pain.15772782
Premature aging syndromeDeregulated Nutrient SensingReduced phosphorylation of transcription factor Elk-1 in cultured fibroblasts of a patient with premature aging syndrome and insulin resistance.15772901
Hypertension, CTCAEDeregulated Nutrient SensingThe relative change in MFVR and M/IG were inversely related, supporting the hypothesis that peripheral vascular changes in hypertension may induce insulin resistance.15775796
DyslipidemiasDeregulated Nutrient SensingThe higher postprandial HBA levels reflect increased hepatic FFA delivery and may aggravate insulin resistance and dyslipidemia, leading to increased cardiovascular risk.15784707
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia, especially lowered high-density lipoprotein cholesterol, also played an important role (HR=2.09, 95% CI=1.33-3.29) in CHD events.15785294
Diabetes Mellitus, Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity.15787895
Obesity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is well recognized both in type 1 diabetes mellitus (T1DM) and in obesity.15787895
OverweightDeregulated Nutrient SensingStudies concerning the relation between insulin resistance and overweight in T1DM have not yet been carried out.15787895
OverweightDeregulated Nutrient SensingT1DM children with insulin resistance based on ID/kg are not more overweight than insulin-sensitive children with T1DM.15787895
OverweightDeregulated Nutrient SensingID/m2 and ID/IW seem to reflect a better tool than ID/kg to describe the influence of overweight on insulin resistance in T1DM.15787895
Inflammation, Tumor necrosisDeregulated Nutrient SensingIncreased levels of inflammation markers, such as C-reactive protein (CRP) and tumor necrosis factor-alpha , have been found in insulin resistance syndrome.15791041
Lipemia - observation, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIncreased postprandial lipemia is part of diabetic dyslipidemia and is associated with accelerated atherosclerosis.15793183
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased urinary albumin excretion, insulin resistance, and related cardiovascular risk factors in patients with type 2 diabetes: evidence of a sex-specific association.15793194
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWhile the relevant role of insulin resistance in the pathogenesis of increased urinary albumin excretion (UAE) is well established in type 1 diabetes, its contribution in type 2 diabetes is controversial.15793194
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur aim was to investigate whether insulin resistance was associated with increased UAE in a large cohort of patients with type 2 diabetes.15793194
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingFinally, ACR was significantly higher in men with two or more insulin resistance-related cardiovascular risk factors (i.e., abdominal obesity, dyslipidemia, and arterial hypertension) than in men with fewer than two insulin resistance-related cardiovascular risk factors (0.90 [0.2-115.1] vs. 1.56 [0.1-1367.6], respectively, P = 0.005).15793194
diabeticDeregulated Nutrient SensingIn type 2 diabetic patients, increased UAE is strongly associated with insulin resistance and related cardiovascular risk factors.15793194
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe definition of dyslipidemia in patients with hypertension was used only when triglyceride or HDL-cholesterol was at abnormal level.15793775
Hypertensive (finding), Dyslipidemias, Metabolic Syndrome XDeregulated Nutrient SensingThe LPL H-X haplotype was one of the protective factors of dyslipidemia of metabolic syndrome in hypertensive patients.15793775
Retinal Dystrophies, Blindness, hearing impairment, Obesity, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlstrom syndrome is a recessively inherited genetic disorder characterized by congenital retinal dystrophy that leads to blindness, hearing impairment, childhood obesity, insulin resistance, and type 2 diabetes mellitus.15795345
Hepatobiliary Disorder, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingPlasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity.15797948
Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingMitochondrial dysfunction has been reported to contribute to insulin resistance (IR) in the elderly and type 2 diabetes.15798952
metabolic disturbanceDeregulated Nutrient SensingDecreased insulin sensitivity, a delayed biological effect, and insulin resistance may serve as the early predictors of carbohydrate metabolic disturbances and severe metabolic pathology.15801640
UremiaDeregulated Nutrient SensingIt is known that insulin resistance in uraemia may be improved with erythropoietin (EPO) and vitamin D therapy.15802034
UremiaDeregulated Nutrient SensingA two-month EPO therapy significantly decreased PC-1 activity to the control values, suggesting that an effect on PC-1 expression could be implicated in the amelioration of insulin resistance in uraemic patients treated with EPO.15802034
MULTISYSTEM DISORDER, HAIR-AN syndrome, HyperandrogenismDeregulated Nutrient SensingThe HAIR-AN syndrome is a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN).15802076
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance measured by the euglycaemic insulin clamp predicts subsequent CHD in elderly men.15803331
UremiaDeregulated Nutrient SensingExperimental studies have shown that increased levels of parathyroid hormone (PTH) in uremia may cause elevation of intracellular calcium, predisposing to insulin resistance and lipid metabolism abnormalities.15807180
Obesity, Abdominal, AtherosclerosisDeregulated Nutrient SensingAbdominal obesity predicts declining insulin sensitivity in non-obese normoglycaemics: the Insulin Resistance Atherosclerosis Study (IRAS).15811139
Diabetes MellitusDeregulated Nutrient SensingWaist circumference should be considered, in addition to BMI, when identifying individuals at high risk of diabetes or the insulin resistance syndrome.15811139
Hypertensive (finding)Deregulated Nutrient SensingEffects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients.15811141
Ventricular FibrillationDeregulated Nutrient SensingThis was associated with WHR reduction, decreases in VF and insulin resistance.15811141
Dyslipidemias, diabeticDeregulated Nutrient SensingCerivastatin increases FVR responses to ACH in type 2 diabetic men with mild dyslipidaemia but only following NO synthase inhibition.15811145
Morbid obesityDeregulated Nutrient Sensing59 patients with morbid obesity were studied with anthropometric assessment and with carbohydrate metabolism assessment through an oral glucose overload and measurement of insulin resistance, before and after a dietary intervention alternating diets of very low caloric content with conventional low-calorie diets.15811276
DyslipidemiasDeregulated Nutrient SensingQuantitative effect of glycaemic improvement on the components of diabetic dyslipidaemia: a longitudinal study.15811569
DyslipidemiasDeregulated Nutrient SensingBivariate correlations and step-wise, multivariate analysis were performed to find predictors of change in the different components of diabetic dyslipidaemia.15811569
DyslipidemiasDeregulated Nutrient SensingIn conclusion, for the component of diabetic dyslipidaemia for which less therapeutic tools are available, glycaemic improvement is most effective.15811569
Impaired health, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn addition, nonobese elderly persons with type 2 diabetes show a marked impairment in insulin release accompanied by mild insulin resistance, whereas obese elderly persons have marked insulin resistance in the presence of "adequate" levels of insulin.15814869
Cell secretionDeregulated Nutrient SensingMarked beta secretory defects seem to be the rule, whereas a significant degree of insulin resistance is unusual.15814869
Hypertensive (finding), Dyslipidemias, Blood PressureDeregulated Nutrient SensingThe use of antiplatelet drugs, lipid-lowering drugs for dyslipidemia, beta blockers, and ACE inhibitors or angiotensin-receptor blockers, reduction of blood pressure to <140/90 mmHg in hypertensive persons, and reduction of hemoglobin A1c in diabetics to <7% in older persons with PAD needs to be increased in all clinical settings.15814871
Overweight, ObesityDeregulated Nutrient SensingOwing the strong correlations between components of the MS and obesity with hs-CRP levels, previous studies about the associations of hs-CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects.15816996
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was defined as TC > or = 220 mg/dl or TG > or = 150 mg/dl.15830273
Kidney Failure, Chronic, DyslipidemiasDeregulated Nutrient SensingThe cumulative incidences of ESRD, per 1000 screenees, were 1.12 for those without dyslipidemia and 2.53 for those with dyslipidemia.15830273
Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance in men with treated hypertension at increased risk for cardiovascular disease: results of a 3-year study.15831352
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is an independent risk factor for cardiovascular disease.15831352
Heart Diseases, Obesity, HereditaryDeregulated Nutrient SensingHereditary antecedents: AHT--46.8%; ischemic cardiopathy and myocardial infarction--15.6%; obesity and dyslipidemia--15.0%; stroke--10.8%.15832974
Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingThese results are promising for health care providers providing advice to postmenopausal women for lifestyle changes to reduce risk of insulin resistance, coronary heart disease, and diabetes.15833948
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingFifty-two percent of patients had dyslipidemia, and 87.6% were overweight, obese, or morbidly obese; tobacco use was documented in 19.5%.15839181
Dyslipidemias, Overweight, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingQuality improvement programs should emphasize the importance of treating hypertensive diabetic patients to their goal BP, as well as controlling other major cardiovascular disease risk factors, such as smoking, dyslipidemia, and overweight or obesity, that are prevalent among these high-risk patients.15839181
hepato-renalDeregulated Nutrient SensingInsulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients.15840056
Kidney Failure, Acute, Critical IllnessDeregulated Nutrient SensingInsulin resistance in critically ill patients with acute renal failure.15840772
Hyperglycemia, Acute respiratory failure, Critical IllnessDeregulated Nutrient SensingHyperglycemia associated with insulin resistance has been associated with adverse outcomes in critically ill intensive care unit (ICU) patients but has not been examined specifically in patients with ARF.15840772
SurvivorsDeregulated Nutrient SensingMean insulin concentrations were significantly higher (431 +/- 508 vs. 234 +/- 189 pmol/l, P = 0.03), mean homeostasis model of insulin resistance levels were significantly higher (24.1 +/- 30.0 vs. 11.7 +/- 12.5, P = 0.04), and IGFBP-3 concentrations were significantly lower (1,190 +/- 498 vs. 1,470 +/- 581 microg/l, P = 0.02) among nonsurvivors compared with survivors.15840772
Hyperglycemia, Acute respiratory failure, Critical IllnessDeregulated Nutrient SensingInsulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF.15840772
Cerebrovascular Disorders, Diabetes Mellitus, Insulin-Dependent, Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingThe present association between low serum HDL-cholesterol and ischaemic stroke patients suggests that aggressive management of dyslipidaemia may protect against cerebrovascular disease in Type 1 diabetes.15842508
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance.15842511
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.15842511
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingFor the ABCC8 exon 18 and the KCNJ11 variant, associations were stronger for studies of clinical diabetes than newly detected glucose intolerance.15842514
Glucose Intolerance (disease), AniridiaDeregulated Nutrient SensingPAX6 is also involved in the development of the endocrine pancreas, and reported to be a genetic factor common to aniridia and glucose intolerance, although the latter is usually mild.15842522
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingStatins have been shown to significantly reduce morbidity and mortality in patients with coronary artery disease (CAD), and also in patients with dyslipidaemia when statins are taken regularly.15842555
Dyslipidemias, MyopathyDeregulated Nutrient SensingBecause the risk for myopathy increases when 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) are used with other agents known to inhibit cytochrome P450 3A4 in patients with dyslipidemia, we sought to quantify this risk in a diverse, real-world sample of patients receiving statin therapy.15843281
ObesityDeregulated Nutrient SensingThe adipokine resistin is suggested to be an important link between obesity and insulin resistance.15843582
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance predisposes to cardiovascular disease and shortens human lifespan.15851602
Diabetes MellitusDeregulated Nutrient SensingData on associations between dietary patterns and the risk of insulin resistance and type 2 diabetes are sparse.15853117
DyslipidemiasDeregulated Nutrient SensingPioglitazone, alone and with metformin, improved lipid components of diabetic dyslipidaemia more than did their respective comparison groups.15854187
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingAwareness and treatment of dyslipidemia in young adults with type 1 diabetes.15855566
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia is a preventable major risk factor for coronary heart disease (CHD).15855566
Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDespite an increased risk of CHD in type 1 diabetes, little is known concerning awareness and adequacy of dyslipidemia treatment in this population.15855566
Dyslipidemias, diabeticDeregulated Nutrient SensingType 1 diabetic subjects had significantly less dyslipidemia than nondiabetic control subjects (47 vs. 58%, P < 0.001), and a higher percentage of those with abnormal lipids were aware of (52 vs. 34%, P < 0.0001), on medication for (36 vs. 9%, P < 0.0001), and in control of their lipid levels (15 vs. 1.4%, P < 0.001).15855566
Diabetes Mellitus, Insulin-Dependent, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia, a major risk factor for CHD, remains largely undiagnosed and undertreated in high-risk populations, such as patients with type 1 diabetes.15855566
Acute Coronary Syndrome, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance is common in Japanese patients with acute coronary syndrome who were not previously diagnosed with diabetes.15855586
Glucose Intolerance (disease), Pancreatic carcinomaDeregulated Nutrient SensingBeta-cell function and insulin resistance evaluated by HOMA in pancreatic cancer subjects with varying degrees of glucose intolerance.15855820
Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingDiabetes associated with pancreatic cancer is likely due to a combination of marked decline in BCF and increased insulin resistance.15855820
Glucose Intolerance (disease), Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingIn addition, we studied 73 pancreatic cancer subjects with glucose intolerance; 21 had impaired FPG and 51 had diabetes.15855820
Increased insulin levelDeregulated Nutrient Sensingfasting hyperinsulinemia (>20.0 microIU/ml) in 32.2%, insulin resistance (I/G>0.30) in 73.7%; in the group of patients with hyperinsulinemia 66.7% had abdominal adiposity.15858253
Colorectal CarcinomaDeregulated Nutrient SensingPeroxisome proliferator-activated receptor-gamma (PPARgamma) has been hypothesized as being involved in colorectal cancer given its role in adipocyte development and insulin resistance.15860437
DyslipidemiasDeregulated Nutrient SensingHemodialysis patients have uremic dyslipidemia, represented by elevated serum intermediate-density lipoprotein cholesterol (IDL-C) levels, and an increased cardiovascular mortality rate.15861352
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingLong-term blockade of the renin-angiotensin system may have a beneficial effect on the acceleration of atherosclerosis and uremic dyslipidemia.15861352
Dyslipidemias, OsteoporosisDeregulated Nutrient SensingWe propose that POMC is among the likely susceptibility genes for osteoporosis and may also be involved in dyslipidemia.15864412
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingConcurrent hypertension and dyslipidemia; obesity and dyslipidemia; and hypertension and obesity occurred in 44.4%, 42.5% and 33.1% of type-2 diabetics, respectively.15868776
Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingIn view of these results, it could be speculated that the adiponectin gene variant, or a mutation in linkage with it, determines lower adiponectin gene expression, causing in turn an increased risk to develop insulin resistance, atherosclerosis and cardiovascular disease.15877215
Dyslipidemias, Chronic disease, ObesityDeregulated Nutrient SensingThe nutritional status was inadequate due to the prevalence of obesity, which results in the appearance of other chronic diseases, such as dyslipidemias.15880207
Prostate carcinomaDeregulated Nutrient SensingHigh insulin levels and insulin resistance have been implicated in prostate cancer development, which has prompted a recent investigation of a possible role for germline variation in the insulin gene (INS) and prostate cancer risk.15880482
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingA cross-sectional survey of lipid levels, cardiovascular disease and risk factors in outpatients treated for dyslipidemia.15882669
Diabetes MellitusDeregulated Nutrient SensingWhile a strong inverse association has been reported between dairy consumption and the insulin resistance syndrome among young obese adults, the relation between dairy intake and type 2 diabetes is unknown.15883237
HypoadiponectinemiaDeregulated Nutrient SensingThe mechanism of hypoadiponectinemia in patients with FRSPH is probably independent of insulin resistance.15884764
Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingAdiponectin, an adipocyte-derived hormone found in lower concentration with greater adiposity, is suggested to reduce the risk of insulin resistance, atherosclerosis, and cardiovascular disease.15886241
Glucose Intolerance (disease), Illness (finding)Deregulated Nutrient SensingDiminished tissue sensitivity to beta-adrenergic signals may contribute to the impaired insulin response and exaggerated glucose intolerance displayed by older patients after injury and during acute illness.15887790
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrevalence and control of dyslipidemia among persons with diabetes in the United States.15890427
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMany persons with diabetes remain uncontrolled for dyslipidemia.15890427
Obesity, AbdominalDeregulated Nutrient SensingIncreased plasma leptin levels with aging suggest resistance to leptin action and may explain why elderly subjects have abdominal obesity and insulin resistance.15893114
Dyslipidemias, Cardiovascular Diseases, AtherosclerosisDeregulated Nutrient SensingChronic hemodialysis patients show a high incidence and prevalence of cardiovascular disease of multifactorial etiology and an association between dyslipidemia and accelerated atherosclerosis.15893756
Diabetes Mellitus, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accidentDeregulated Nutrient SensingBody mass index (OR 1.08; 95% CI 1.05-1.11), diabetes mellitus (1.4; 1.09-1.79), ischemic heart disease (1.38, 1.08-1.75) and stroke (1.30; 1.0-1.69) were independent factors associated with dyslipidemia.15893756
Schizophrenia, ObesityDeregulated Nutrient SensingGender differences in association of plasma adiponectin with obesity reflect resultant insulin resistance in non-diabetic Japanese patients with schizophrenia.15896219
Adenoma of large intestineDeregulated Nutrient SensingAssociation of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance.15897559
Carcinogenesis, Obesity, AbdominalDeregulated Nutrient SensingColorectal carcinogenesis is thought to be related to abdominal obesity and insulin resistance.15897559
Carcinogenesis, Obesity, AbdominalDeregulated Nutrient SensingThis study may offer a new insight to understanding the relationship of colorectal carcinogenesis with abdominal obesity and insulin resistance.15897559
Apolipoproteins B, Dyslipidemias, diabeticDeregulated Nutrient SensingA potential role of apolipoprotein B in the risk stratification of diabetic patients with dyslipidaemia.15904989
DyslipidemiasDeregulated Nutrient SensingDiabetic dyslipidaemia is characterised by retention of atherogenic particles, which are depleted of cholesterol.15904989
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined the potential role of apolipoprotein B in the risk stratification of Omani patients with type 2 diabetes and dyslipidaemia.15904989
Dyslipidemias, diabeticDeregulated Nutrient SensingThese findings suggest that the ratios of apoB/LDL cholesterol and apoB/non-HDL cholesterol may have a role in the risk stratification of diabetic patients with dyslipidaemia.15904989
DyslipidemiasDeregulated Nutrient SensingMeasuring VLDL-cholesterol may be helpful for understanding the pathological features of diabetic dyslipidaemia.15907189
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe rates of overweight, obesity, and dyslipidemia rose significantly (p < 0.05) independently from age, federal state, and gender.15909748
ObesityDeregulated Nutrient SensingThis risk was independent of age, sex, obesity, triglyceride level, HDL cholesterol and pattern of insulin resistance.15910632
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingA multivariate statistical analysis showed that male sex, age, and dyslipidaemia were independent predictors of critical atherosclerosis.15917275
ObesityDeregulated Nutrient SensingBoth total and central obesity are associated with insulin resistance and with an atherogenic lipoprotein profile.15917851
Acanthosis Nigricans, Polycystic Ovary Syndrome, HyperandrogenismDeregulated Nutrient SensingParticular forms of polycystic ovary syndrome with severe hyperandrogenism, acanthosis nigricans, and marked insulin resistance, defining the type A insulin resistance syndrome, are due to insulin receptor gene mutations.15919811
Acanthosis Nigricans, LipodystrophyDeregulated Nutrient SensingThis mutation cosegregated with impaired glucose tolerance, insulin resistance, and acanthosis nigricans in the absence of clinical lipodystrophy in the family.15919811
DiseaseDeregulated Nutrient SensingThis study further extends the vast range of diseases linked to LMNA mutations and identifies another genetic cause for the type A insulin resistance syndrome.15919811
Diabetes MellitusDeregulated Nutrient SensingTo test the hypothesis that lower vital capacity is cross-sectionally associated with features of insulin resistance and is an independent predictor of incident type 2 diabetes.15920070
Diabetes MellitusDeregulated Nutrient SensingPulmonary factors related to vital capacity deserve attention as possible risk factors for insulin resistance and diabetes.15920070
square decimeterDeregulated Nutrient Sensingbeta-Cell function declined significantly in the patients with IGT and DM2, and insulin resistance increased significantly.15921179
Obesity, Structure of posterior cerebral arteryDeregulated Nutrient SensingBecause insulin resistance in the setting of obesity is associated with the development of PCa, we hypothesized that decreased adiponectin levels might underlie the association between PCa and obesity/insulin resistance.15922427
Asthma, Allergy - Charge Type ReasonDeregulated Nutrient SensingThe authors hypothesise that insulin resistance may play a role in asthma and allergy.15923242
Liver CirrhosisDeregulated Nutrient SensingHyperglucagonemia has been described to be associated with insulin resistance in patients with liver cirrhosis.15926112
Dyslipidemias, Multiple Chronic Conditions, Depression, CTCAE, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients had multiple diseases including type 2 diabetes mellitus (n = 23), hypertension (n = 48), depression (n = 18), and dyslipidemia (n = 9).15928261
Vascular Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe cross-sectional IRIS-II study tried to assess the prevalence of insulin resistance and macrovascular disease in orally treated patients with Type 2 diabetes.15929679
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingThe results confirm that fasting intact proinsulin is a suitable measure for beta-cell dysfunction and insulin resistance in type 2 diabetes and may be used to support therapeutic decisions.15929679
Kidney DiseasesDeregulated Nutrient SensingInsulin resistance and postprandial triglyceride levels in primary renal disease.15931621
No metabolic abnormalities, Dyslipidemias, Kidney FailureDeregulated Nutrient SensingRenal failure is associated with a range of metabolic abnormalities including insulin resistance and dyslipidemia.15931621
Kidney Failure, Kidney DiseasesDeregulated Nutrient SensingWe examined the role of creatinine clearance (CrCl) and body composition in the development of insulin resistance in patients with primary renal disease and a variable degree of renal failure.15931621
Decline in functional statusDeregulated Nutrient SensingInsulin resistance increased with decline in renal function and was significantly higher in patients with CrCl less than 60 mL/min compared to subjects with CrCl greater than 60 mL/min or carefully matched controls.15931621
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingGenetic polymorphism of apo E has been reported as an important dyslipidemia genetic marker associated with coronary artery disease.15936467
DyslipidemiasDeregulated Nutrient SensingWe think that these results corroborate that in the etiology of the dyslipidemia, there is more than one associate genetic marker.15936467
Metabolic Syndrome XDeregulated Nutrient SensingThe metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men.15939060
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMost were taking medications for hypertension (67%) and dyslipidemia (62%).15939916
Diabetes MellitusDeregulated Nutrient SensingGroup I comprised patients with insulin resistance, abnormal fasting blood glucose or glucose tolerance, type 2 diabetes.15940190
Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingProtective food commodities in the prevention of cardiovascular disease, insulin resistance syndrome or diabetes are crucial components of the vegetarian diet.15940383
DyslipidemiasDeregulated Nutrient SensingLow plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia.15941898
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased serum resistin levels in patients with type 2 diabetes are not linked with markers of insulin resistance and adiposity.15944845
Hyperlipidemia, ObesityDeregulated Nutrient SensingHowever, there was no correlation in either patient group between serum resistin levels and markers of insulin resistance, obesity or hyperlipidaemia.15944845
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTaken together, these findings demonstrate that serum resistin levels are increased in patients with type 2 diabetes, but this increase is not linked to markers of insulin resistance or adiposity.15944845
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGastric bypass has repeatedly been shown to improve and even cure type 2 diabetes by substantially improving insulin resistance.15946424
Weight decreased, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe changes in insulin resistance seen after gastric bypass, which are responsible for the resolution or improvement of type 2 diabetes occur within 6 days of the surgery, before any appreciable weight loss has occurred.15946424
Arthropathy, Dyslipidemias, Morbid obesity, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingRegarding the diseases associated with morbid obesity, arterial hypertension was observed in 67.9% (n=76) of the patients, joint diseases in 55.4% (n=62), dyslipidemia in 40.2% (n=45), and diabetes type 2 in 27.7% (n=31).15946458
Cerebrovascular accidentDeregulated Nutrient SensingPrior research has indicated an association between insulin resistance and stroke; we sought to determine if this association persists after adjusting for stroke risk factors, including glycemic control.15947493
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe results reinforce the importance of interventions to reduce physical inactivity, alcohol consumption, obesity and dyslipidemia, so as to prevent increasing incidence of diabetes.15947833
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLiver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus.15948897
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingElevated ALT levels are associated with insulin resistance, and subjects with NAFLD have features of the metabolic syndrome that confer high-risk cardiovascular disease.15948897
Nonalcoholic Steatohepatitis, HypomagnesemiaDeregulated Nutrient SensingHypomagnesemia, insulin resistance, and non-alcoholic steatohepatitis in obese subjects.15950075
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingAs nonalcoholic steatohepatitis (NASH) seems to be related to insulin resistance, the aim of this study was to determine the potential relationship between DSML and NASH in obese subjects.15950075
Non-insulin Hypoglycemic, Insulin Resistance, Diabetes MellitusDeregulated Nutrient SensingWe compared obese individuals with the diagnosis of diabetes, insulin-resistance, and non-insulin resistance to a control group of non-obese, non-insulin-resistant subjects.15950075
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingInsulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown.15951550
Fatty Liver, Fibrosis AssessmentDeregulated Nutrient SensingLogistic regression and multivariate regression analysis were used to identify variables independently associated with insulin resistance, fatty liver, and fibrosis.15951550
Fatty degenerationDeregulated Nutrient SensingIndependent risk factors for steatosis were insulin resistance in genotype 1 patients (p = 0.001) and viral load in genotype 3 patients (p = 0.003).15951550
Fatty degenerationDeregulated Nutrient SensingAmong genotype 1 patients, independent parameters associated with insulin resistance were age (p = 0.04) and steatosis (p = 0.004).15951550
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingThis study shows that insulin resistance is the cause rather than the consequence of steatosis and fibrosis in genotype 1 patients and that increased circulating insulin is a risk factor for fibrosis through insulin resistance induced steatosis.15951550
Kidney Failure, Chronic, insensitivityDeregulated Nutrient SensingThe CAPD treatment may lead to insulin insensitivity in non-diabetic end-stage renal disease patients and the high glucose content of CAPD solutions may be responsible for insulin resistance in CAPD patients.15951871
Glucose Intolerance (disease), Beta-cell dysfunctionDeregulated Nutrient SensingIn conclusion, elevated serum GGT levels predict glucose intolerance probably via insulin resistance rather than beta-cell dysfunction.15952086
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Association between insulin resistance and cholesteryl ester transfer protein gene polymorphism in type 2 diabetes mellitus].15952120
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo study the association between cholesteryl ester transfer protein (CETP) gene polymorphism and insulin resistance in type 2 diabetes.15952120
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma lipids, fasting insulin, insulin sensitivity index and insulin resistance index were determined in 108 patients with type 2 diabetes.15952120
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt may be an important risk factor of insulin resistance in type 2 diabetes.15952120
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance in type 2 diabetes subjects was investigated before and 6 months after insulin administration in 43 type 2 diabetes patients (28 females and 15 males).15955377
Weight Gain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, insulin treatment of type 2 diabetes patients leads to decrease in insulin resistance due to reduction in glucose toxicity and plasma atherogenicity despite weight gain.15955377
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingType 1 diabetes developed in a type 2 diabetic patient with severe insulin resistance.15955587
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe report a 38-year-old female with severe insulin resistance who developed type 1 diabetes after being diagnosed with type 2 diabetes.15955587
Muscle CrampDeregulated Nutrient SensingFurther, a hyperinsulinemic-euglycemic cramp study using an artificial pancreas showed that the patient had severe insulin resistance [glucose infusion rate 1.8 mg/(min kg); normal, 7.4+/-2.4 (mean+/-S.D.)].15955587
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingGuidelines for the management of dyslipidemia in patients with chronic kidney disease are based on results from the fasting lipid profile, which can be difficult to obtain from patients on an afternoon or night dialysis schedule.15957136
Cardiac complication, Dyslipidemias, HyperfibrinogenemiaDeregulated Nutrient SensingIn peritoneally dialyzed patients glucose load into the peritoneum, dyslipidemia and hiperfibrinogenemia may further contribute at the cardiovascular complications.15962607
Ovarian enlargementDeregulated Nutrient SensingOvarian enlargement is a constant feature of syndromes of extreme insulin resistance.15963065
Lipodystrophy, Rabson-Mendenhall Syndrome, SyndromeDeregulated Nutrient SensingSeven young patients with syndromes of extreme insulin resistance (five with lipodystrophy, one with Type B syndrome and one with Rabson-Mendenhall syndrome) were studied.15963065
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe objective was to determine whether systems of care implemented within a large medical group are associated with improved treatment and control of dyslipidemia in a high-risk group of coronary heart disease patients.15963307
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, MS geneDeregulated Nutrient SensingIn most cases, it is the hallmark of non-alcoholic fatty liver disease (NAFLD), a potentially progressive disease associated with insulin resistance and the metabolic syndrome (MS).15966506
Hepatocellular necrosisDeregulated Nutrient SensingWe tested the hypothesis that insulin resistance per se might be associated with hepatocellular necrosis.15966506
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingWe conclude that in obesity insulin resistance is a risk factor for raised liver enzyme levels, possibly related to NAFLD.15966506
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, diabeticDeregulated Nutrient SensingDiabetes disappeared in 97% of diabetic subjects, blood pressure normalized in 53% of subjects with hypertension and serum lipid levels returned to normal in 88% of subjects with dyslipidemia.15970974
HyperglycemiaDeregulated Nutrient SensingA common variant in mitochondrial DNA (mtDNA) at bp 16189 (T-->C transition) has been associated with small birth size, adulthood hyperglycemia, and insulin resistance in Caucasians.15972579
Increased insulin levelDeregulated Nutrient SensingThis clustering is commonly associated with pre-diabetic hyperinsulinemia and it reflects peripheral insulin resistance.15977101
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn logistic regression analysis, NAFLD was associated with a percent FMV in the lower tertile (OR, 6.7; 95% CI, 1.26-36.1), after adjustment for age, sex, body mass index, and insulin resistance.15981216
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn type 2 diabetes, microalbuminuria is strongly related to insulin resistance.15983223
Prediabetes syndrome, AtherosclerosisDeregulated Nutrient SensingNuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study.15983261
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingElevated insulin resistance, blood pressure, and dyslipidemia (including small dense LDL) predicted incident diabetes.15983261
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe enrolled subjects with a diagnosis of type 2 diabetes (treated with diet alone or oral monotherapy) and dyslipidemia (not treated with any lipid-lowering agents).15983299
Impaired mitochondrial functionDeregulated Nutrient SensingThese data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.15983313
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe disease is determined by many risk factors such as age, gender, diabetes, dyslipidemia, smoking, as well as elevated serum levels of lipoprotein (a) (Lp(a)), homocysteine, C-reactive protein (CRP) and uric acid.15985286
DyslipidemiasDeregulated Nutrient SensingThe interaction between thyroid function and insulin sensitivity is an important contributor to diabetic dyslipidemia and may justify T4 replacement in some patients.15985488
Tumor necrosisDeregulated Nutrient SensingVisceral adipose tissue and tumor necrosis factor alpha were the only predictors of calculated insulin resistance ( P < .05), explaining 43% of the variability.15988694
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIntact proinsulin is a marker for pancreatic beta-islet cell secretion status, and elevated levels indicate insulin resistance of type 2 diabetic patients with a high diagnostic specificity.15991797
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingOur additional finding that intact proinsulin is stable in EDTA whole blood samples, which can be obtained from the routine.sample for HbA1c measurement, is increasing the probability of the acceptance of this marker for routine assessment of beta-cell dysfunction and insulin resistance in type 2 diabetes.15991797
Thrombosis, DyslipidemiasDeregulated Nutrient SensingHigh IL-6, TNF-alpha, and dyslipidemia are risk factors for thrombosis.15992611
DyslipidemiasDeregulated Nutrient SensingB+ patients showed increased HSP70-2, IL-6, IFN-gamma, TNF-alpha and dyslipidemia as compared to B- carriers.15992611
AlbuminuriaDeregulated Nutrient SensingThe inclusion of albuminuria and insulin resistance by the WHO has made it the most discriminative criterion in identifying at risk individuals in all age groups.16005365
Abnormal circulating valine concentrationDeregulated Nutrient SensingThese results suggest that the predisposing metabolic abnormality in non-obese subjects with IGT alone or IFG alone and in progression to IFG+IGT might be deterioration of early phase insulin secretion, whereas insulin resistance might be the major contributory factor in obese subjects.16005368
No metabolic abnormalities, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingTo investigate the clinical characteristics and predisposing metabolic abnormalities in the development of glucose intolerance and diabetes mellitus in obese and non-obese Korean subjects.16005368
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingStrategies to improve nutrition and to identify and treat cardiovascular risk factors such as dyslipidaemia and hypertension are urgently required.16005463
DyslipidemiasDeregulated Nutrient SensingHowever, the C-allele has suggested to be linked to dyslipidemia.16005884
Hyperlipidemia, Glucose Intolerance (disease)Deregulated Nutrient SensingTo report a case of epidural lipomatosis in a patient with abnormal adipose tissue distribution, glucose intolerance and mixed hyperlipidemia.16007467
Impaired cognitionDeregulated Nutrient SensingInsulin resistance in cognitive impairment: the InCHIANTI study.16009759
Impaired cognitionDeregulated Nutrient SensingTo test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population.16009759
Impaired cognition, Cerebrovascular accidentDeregulated Nutrient SensingThe insulin resistance profile of patients in the CI/SF+ group was similar to that of individuals who had experienced stroke, whereas the profile of individuals with cognitive impairment without subcortical features (CI/SF- group) was similar to that of individuals in the no CI group.16009759
Impaired cognitionDeregulated Nutrient SensingCognitive impairment with but not without subcortical features is associated with biochemical and clinical features of insulin resistance syndrome.16009759
Impaired cognitionDeregulated Nutrient SensingIn epidemiologic populations, insulin resistance might contribute to cognitive impairment through a vascular mechanism.16009759
Extrahepatic, Hepatitis C, Diabetes Mellitus, Non-Insulin-Dependent, Liver diseasesDeregulated Nutrient SensingHepatitis C virus (HCV) causes extrahepatic manifestations as well as liver diseases, and contributes to insulin resistance and type 2 diabetes mellitus.16012764
Hepatitis CDeregulated Nutrient SensingInsulin resistance induces HCV infection, which causes an increase in the incidence of extrahepatic manifestations in HCV-infected individuals.16012764
Insulin resistance syndromeDeregulated Nutrient SensingHigh-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome.16012940
Dyslipidemias, Depression, CTCAEDeregulated Nutrient SensingIt is strongly associated with increasing age, dyslipidemia, and depression.16014053
Dyslipidemias, Biliary calculi, Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingIncreasing age, familial history of the disease, unhealthy lifestyle, overweight, dyslipidemia, type 2 diabetes and high plasma insulin levels are all associated with gallstones.16014208
Inflammation, Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThese results suggest a possible role of subclinical inflammation in insulin resistance and glucose intolerance in Japanese, but it only partly explains the link between obesity and impaired glucose homeostasis.16020877
Glucose Intolerance (disease), Behavior DisordersDeregulated Nutrient SensingThe findings are consistent with an inverse linear relation between a cluster of core protective, lifestyle-related factors and the prevalence of both glucose intolerance and insulin resistance.16026378
ObesityDeregulated Nutrient SensingIndeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005).16029943
Prostate carcinomaDeregulated Nutrient SensingThese results suggest that genetic variants in the DNA repair pathways may be involved in prostate cancer etiology and that other risk factors, including preserved foods and insulin resistance, may modulate prostate cancer risk in combination with genetic susceptibility in these repair pathways.16030105
Congestive heart failureDeregulated Nutrient SensingInsulin resistance and risk of congestive heart failure.16030278
Diabetes Mellitus, Obesity, Congestive heart failureDeregulated Nutrient SensingDiabetes and obesity are established risk factors for congestive heart failure (CHF) and are both associated with insulin resistance.16030278
Obesity, Congestive heart failureDeregulated Nutrient SensingTo explore if insulin resistance may predict CHF and may provide the link between obesity and CHF.16030278
Congestive heart failure, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance predicted CHF incidence independently of established risk factors including diabetes in our large community-based sample of elderly men.16030278
Obesity, Congestive heart failureDeregulated Nutrient SensingThe previously described association between obesity and subsequent CHF may be mediated largely by insulin resistance.16030278
Diabetes MellitusDeregulated Nutrient SensingImmune gene variants in man and in animal models were found to affect insulin resistance and diabetes incidence.16032528
Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingLeptin might have a beneficial effect on CHD in type 2 diabetes, probably by counteracting the effect of insulin-like molecules or insulin resistance.16038995
No metabolic abnormalitiesDeregulated Nutrient SensingCigarette smoking is associated with increased insulin resistance and other metabolic abnormalities.16039294
Dyslipidemias, Depressed moodDeregulated Nutrient SensingOn the other hand, dyslipidemia was less common in patients with depressed LV function (35.4% vs. 56.9%, p = 0.01).16041968
Dyslipidemias, Diabetes Mellitus, physiopathological, ImpairedDeregulated Nutrient SensingAfter adjustment for ST-elevation location and number of vessels with critical stenosis, diabetes and smoking were associated with a significantly higher risk of LVEF impairment (diabetes: OR = 3.73, 95% CI 1.25-11.16; smoking: OR = 3.9, 95% CI 1.37-11.07) and dyslipidemia with a significantly lower risk of LV dysfunction (OR: 0.37, 95% CI 0.15-0.88).16041968
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdministration of DHEA to rats and mice reduces visceral fat accumulation, and improves insulin resistance in experimental models of diet-induced obesity and/or Type 2 diabetes.16042365
palladium, Malnutrition, Dyslipidemias, peritonealDeregulated Nutrient SensingThe high Levels of glucose, glucose degradation products (GDPs), and lactate buffer present in standard peritoneal dialysis (PD) solutions contribute to peritoneal damage, malnutrition, and dyslipidemia.16048260
Cholelithiasis, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance is a risk factors for non-alcoholic fatty liver disease (NAFLD) and for gallstone disease (GD).16048564
AtherosclerosisDeregulated Nutrient SensingInsulin resistance has been proposed as an important risk factor in the development of atherosclerosis.16050951
Coronary StenosisDeregulated Nutrient SensingThese results suggest that insulin resistance may play a major role in the development of diffuse coronary artery stenosis.16050951
InflammationDeregulated Nutrient SensingKnowledge of the factors which simultaneously contribute to insulin-resistance-related inflammation may contribute to early therapeutic targeting.16052331
AtherosclerosisDeregulated Nutrient SensingIL-18 has recently been described as one of the factors which, in addition to insulin resistance, may also contribute to atherosclerosis.16052331
Turner Syndrome, PseudohermaphroditismDeregulated Nutrient SensingFemale pseudohermaphroditism due to classical 21-hydroxylase deficiency and insulin resistance in a girl with Turner syndrome.16052861
HyperandrogenismDeregulated Nutrient SensingImprovement in insulin resistance after treatment of hyperandrogenism has not been previously reported.16052861
Diastolic dysfunction, Hypertension, CTCAE, HypertrophyDeregulated Nutrient SensingLeft ventricular (LV) hypertrophy and diastolic dysfunction, which are common cardiac consequences of hypertension, are modified by insulin resistance.16053992
Hypertensive (finding)Deregulated Nutrient SensingThe present study assessed the hypothesis that primary treatment of insulin resistance may reverse such cardiac changes in hypertensive patients.16053992
Hypertensive (finding)Deregulated Nutrient SensingThe present findings demonstrate that pioglitazone improves LV diastolic function without LV mass regression in hypertensive patients in proportion to the amelioration of insulin resistance.16053992
Inflammation, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingHemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension.16060120
Inflammation, Hyperparathyroidism, AnemiaDeregulated Nutrient SensingThe prevalence of insulin resistance and its relationship between anemia, secondary hyperparathyroidism, inflammation, and cardiac parameters in chronic hemodialysis patients.16060127
Kidney Failure, ChronicDeregulated Nutrient SensingInsulin resistance (IR) frequently accompanies end-stage renal disease (ESRD).16060127
Kidney Failure, ChronicDeregulated Nutrient SensingBecause insulin resistance is an independent risk factor of cardiovascular mortality in ESRD patients, it was accepted that being able to correct the insulin resistance could be a novel therapeutic approach in this cohort.16060127
Steatohepatitis, ObesityDeregulated Nutrient SensingObesity and insulin resistance play a major role in the development of liver steatosis (LS), but also relative leptin resistance has been reported to correlate with LS in humans.16061835
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingInsulin resistance and carotid atherosclerosis in 221 patients with potential hyperglycemia.16075748
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingTo investigate the relationship between insulin resistance and carotid atherosclerosis in patients with potential hyperglycemia.16075748
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHaving diabetes (HR 0.86; 95% CI 0.79 to 0.94) and dyslipidemia (HR 0.71; 95% CI 0.66 to 0.76) increased the rate of persistence.16076920
Coronary heart diseaseDeregulated Nutrient SensingPlasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women.16076942
Vascular Diseases, Diabetes MellitusDeregulated Nutrient SensingIt is premature to consider adiponectin as a root for vascular disease in women despite its association with insulin resistance and diabetes.16076942
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOverweight Hispanic children with a family history of type 2 diabetes may represent a unique population given that pubertal insulin resistance was not evident once analyses controlled for body composition.16077712
Metabolic Syndrome X, ObesityDeregulated Nutrient SensingTraditional cardiovascular risk factors such as central obesity, high blood pressure and insulin resistance, all constituents of metabolic syndrome, have been associated with increased levels of C-reactive protein (CRP).16077717
ObesityDeregulated Nutrient SensingSerum resistin is not associated with obesity or insulin resistance in humans.16080635
Obesity, Diabetes MellitusDeregulated Nutrient SensingResistin has proposed link with obesity related insulin resistance and type 2 diabetes.16080635
ObesityDeregulated Nutrient SensingIt is suggested that circulating resistin levels are not associated with obesity or insulin resistance in humans.16080635
RestenosisDeregulated Nutrient SensingInsulin resistance as a predictor for restenosis after coronary stenting.16080969
RestenosisDeregulated Nutrient SensingThe rationale of this study was to determine whether insulin resistance is an independent risk factor for restenosis after coronary stenting.16080969
RestenosisDeregulated Nutrient SensingHowever, it has not been determined whether insulin resistance is independently related to restenosis after coronary stenting.16080969
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingRestenosis was influenced by insulin resistance [Relative Risk (RR) 2.06; 95 percent confidence interval (95%CI) 1.20 to 3.56], diabetes mellitus (DM: RR 1.92; 95%CI 1.25 to 2.95), and final minimal lumen diameter (RR 2.83; 95%CI 1.32 to 6.06).16080969
Diabetes MellitusDeregulated Nutrient SensingDysfunction in mitochondrial oxidative phosphorylation plays a central role in insulin resistance and type 2 diabetes.16082529
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFurther surveillance in this population is essential in verifying the impact of dyslipidemia as a risk of cardiovascular disease in rural Thai adults.16083223
Acute myocardial infarction, Glucose Intolerance (disease)Deregulated Nutrient SensingLeft ventricular diastolic function in normotensive subjects 2 months after acute myocardial infarction is related to glucose intolerance.16084165
Glucose Intolerance (disease), Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction, LeftDeregulated Nutrient SensingBoth glucose intolerance and myocardial infarction are independently associated with impaired left ventricular (LV) function.16084165
Hyperglycemia, Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingIndependent of LVEF, the pattern of abnormal LV filling in normotensive subjects 2 months after AMI is a function of the severity of glucose intolerance, restrictive in the majority of the diabetic patients and nonrestrictive in the majority of the euglycemic patients, impaired glucose tolerance, and stress hyperglycemia.16084165
Demographics Domain, Cardiovascular Diseases, Refractory anemias, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingFrequencies of risk factors among the RA patients compared with controls were hypertension (28% versus 32%), smoking (37% versus 29%), dyslipidemia (23% versus 25%), diabetes mellitus (DM) (14% versus 14%), and family history of cardiovascular disease (CVD) (4% versus 7%).16084220
ETV3 wt AlleleDeregulated Nutrient SensingBoth the MetS and insulin resistance are strong and mutually independent predictors of vascular risk among angiographed coronary patients.16091486
Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingSelenium as a component of glutathione peroxidase may be beneficial in insulin resistance, hence potentially may modify the risk of diabetes and cardiovascular disease (CVD).16093402
palladium, Dyslipidemias, Mental disordersDeregulated Nutrient SensingDyslipidemia, psychological disorders and presence of at least 1 risk factor were significantly associated with PD.16094040
Cryoglobulinemia, DyslipidemiasDeregulated Nutrient SensingPrednisone administration was effective in classical cryoglobulinaemia symptoms and also in dyslipidaemia.16095015
Fatty Liver, Hyperglycemia, Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingThe abnormal rates for conventional IHD risk factors including hypertension, dyslipidemia, hyperglycemia and overweight increased in accordance with the severity of fatty liver.16097054
Nonalcoholic SteatohepatitisDeregulated Nutrient SensingInsulin resistance and oxidative stress induced by products of small intestinal bacterial activity are putative factors in the pathogenesis of non-alcoholic steatohepatitis.16097995
HypoglycemiaDeregulated Nutrient SensingTherefore, we suspected that she had reactive hypoglycemia associated with insulin resistance and treated her with 15 mg/day pioglitazone.16098929
HypoglycemiaDeregulated Nutrient SensingThus, we believe that pioglitazone is effective for reactive hypoglycemia and aggravated glycemic metabolism associated with insulin resistance.16098929
Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, NephrolithiasisDeregulated Nutrient SensingInsulin resistance is a central feature of type 2 diabetes mellitus (DM) and may increase the risk of kidney stone formation.16105055
Kidney CalculiDeregulated Nutrient SensingBecause insulin resistance can precede the diagnosis of DM by decades, we also prospectively examined the relation between kidney stones and the diagnosis of incident DM.16105055
Glucose Intolerance (disease), Coronary heart diseaseDeregulated Nutrient SensingGlucose intolerance is associated with C-reactive protein and intima-media anatomy of the common carotid artery in patients with coronary heart disease.16108851
Glucose Intolerance (disease), Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance was associated with hs-CRP and cIMa in patients with coronary heart disease without known diabetes mellitus.16108851
Dyslipidemias, DysglycemiaDeregulated Nutrient SensingDyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients.16109522
Muscular Atrophy, Cerebrovascular accident, Diabetes MellitusDeregulated Nutrient SensingStroke patients have gross muscular atrophy and high prevalence of diabetes and insulin resistance.16109906
Dyslipidemias, Antihypertensive Agents, ObesityDeregulated Nutrient SensingPrevalence of obesity and dyslipidaemia in hypertensives seen in Abuja, Nigeria.16112955
Dyslipidemias, Hypertension, CTCAE, Antihypertensive Agents, ObesityDeregulated Nutrient SensingThis is a report of observations on a hospital-based study over the prevalence of obesity and dyslipidaemia seen in hypertensives attending our hypertension clinic.16112955
Vascular Diseases, Metabolic Syndrome X, Atherosclerosis, Dyslipidemias, ObesityDeregulated Nutrient SensingThe LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases.16117820
AlopeciaDeregulated Nutrient SensingWe hypothesized that not only the mental aspects but also certain physical aspect of women's health, such as insulin resistance, have an important role in the determination of HRQOL among women with hair loss.16120206
AlopeciaDeregulated Nutrient SensingFurthermore, the prevalence rates of IGR and insulin resistance measured by QUICKI were higher among the women with hair loss than those with normal hair.16120206
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingThe use of Achilles tendon sonography to distinguish familial hypercholesterolemia from other genetic dyslipidemias.16123315
DyslipidemiasDeregulated Nutrient SensingSonographic AT characteristics are normal in non-FH dyslipidemias.16123315
ItalyDeregulated Nutrient SensingThe functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.16123373
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2 diabetes.16123373
Diabetes MellitusDeregulated Nutrient SensingTRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance.16123373
diabeticDeregulated Nutrient SensingWe here report that the prevalent TRB3 missense Q84R polymorphism is significantly (P < 0.05) associated with several insulin resistance-related abnormalities in two independent cohorts (n = 178 and n = 605) of nondiabetic individuals and with the presence of a cluster of insulin resistance-related cardiovascular risk factors in 716 type 2 diabetic patients (OR 3.1 [95% CI 1.2-8.2], P = 0.02).16123373
Diabetes MellitusDeregulated Nutrient SensingDespite the presence of severe insulin resistance, the patient did not develop overt diabetes mellitus at the time of investigation.16127220
Glucose Intolerance (disease), Colorectal CarcinomaDeregulated Nutrient SensingGlucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People.16127231
Glucose Intolerance (disease), Colorectal CarcinomaDeregulated Nutrient SensingGlucose intolerance may increase the risk of developing colorectal cancer.16127231
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingSOD and GPx activities and TAS were lower in men with advanced coronary atherosclerosis that in age-matched clinically healthy men with similar dyslipidemia and were even further decreased compared with clinically healthy men without dyslipidemia.16127364
insulinoma, NEUROD1 wt AlleleDeregulated Nutrient SensingNIDDM is characterized by progressive insulin resistance and the failure of insulin-producing pancreatic beta cells to compensate for this resistance.16127460
Increased insulin level, InflammationDeregulated Nutrient SensingHyperinsulinemia, inflammation, and prolonged activation of the insulin receptor (INSR) have been shown to induce insulin resistance by decreasing INSR substrate (IRS) protein levels.16127460
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCharacteristics of type 2 diabetes in terms of insulin resistance in Korea.16127772
diabeticDeregulated Nutrient SensingThe aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients.16127772
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance.16127772
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingOld age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.16127772
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingTwenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance.16127779
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAttenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.16129690
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease.16129690
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInhibition of serine 307 phosphorylation by rapamycin mimicked type 2 diabetes and reduced the sensitivity of IRS1 tyrosine phosphorylation in response to insulin, while stimulation of the phosphorylation by okadaic acid, in cells from patients with type 2 diabetes, rescued cells from insulin resistance.16129690
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings identify a molecular mechanism for insulin resistance in non-selected patients with type 2 diabetes.16129690
Glucose Intolerance (disease), Dyslipidemias, ObesityDeregulated Nutrient SensingThe features of the MS were characterized as five factors (obesity, dyslipidemia, elevated blood pressure, glucose intolerance, and insulin resistance), which were combined to create an MS summary score.16129731
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingBasing on above mentioned results it may be concluded that essential hypertension (especially if complicated with dyslipidemia) impairs fibrinolysis, what might be related to renin-angiotensin system activation in lipid metabolism disorders.16130596
Diabetes MellitusDeregulated Nutrient SensingThe proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions.16132956
diabeticDeregulated Nutrient SensingUsing Homa and modified Homa formula to evaluate the insulin resistance and islet beta cell function both in the normal and diabetic subjects was similar.16134594
Colorectal Carcinoma, ColitisDeregulated Nutrient SensingA pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation.16136044
Carcinogenesis, Colorectal Carcinoma, ColitisDeregulated Nutrient SensingColorectal cancer risk is associated with biochemical markers for B-vitamin deficiency, insulin resistance and colonic inflammation, suggesting that these three conditions are each involved in colon carcinogenesis.16136044
ColitisDeregulated Nutrient SensingOur supplemental strategy modestly affected some of the biomarkers associated with folate metabolism and insulin resistance, but had no effect on those associated with colonic inflammation.16136044
Diabetes MellitusDeregulated Nutrient SensingEffect of jiang zhuo mixture on blood glucose level and insulin resistance in diabetes.16136948
Endothelial dysfunctionDeregulated Nutrient SensingThe role of intact proinsulin and adiponectin in endothelial dysfunction and insulin resistance has been receiving increasing attention.16138267
diabeticDeregulated Nutrient SensingInterleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients.16140413
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInterleukin-6 (IL-6), a powerful inflammatory mediator, plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes.16140413
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings highlight that IL-6-174 G > C polymorphism affects insulin resistance in type 2 diabetes, where C+ carriers have an insulin resistance "IL-6-sensitive", while C- carriers do not.16140413
diabeticDeregulated Nutrient SensingThe identification of two categories of diabetic patients may, therefore, lead to different therapeutic strategies in the management of insulin resistance.16140413
Diabetic Nephropathy, Tumor necrosis, ObesityDeregulated Nutrient SensingThe G-308A polymorphism in the promoter region of the tumor necrosis factor alpha (TNF-alpha) gene has been reported to be associated with insulin resistance and obesity, both of which may increase the risk of diabetic nephropathy.16141456
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus was defined as glucose intolerance either treated dietary, with oral hypoglycemics or with insulin.16142517
Apolipoprotein E, DyslipidemiasDeregulated Nutrient SensingApolipoprotein E polymorphism is an important genetic marker for dyslipidemia.16142566
Fatty LiverDeregulated Nutrient SensingTNFalpha induces insulin resistance and promoter polymorphisms of TNFalpha gene affect the release of this cytokine, implicated in the pathogenesis of HCV-related diabetes and fatty liver.16143422
Liver damage, Fatty degenerationDeregulated Nutrient SensingTNFalpha pathway activity was correlated with LDL cholesterol, steatosis, and insulin resistance, which, in turn, was correlated with the severity of liver damage.16143422
InflammationDeregulated Nutrient SensingFurthermore, it may be involved in regulative processes taking place in insulin resistance and inflammation.16144855
Hypertension, CTCAEDeregulated Nutrient SensingHypertension, and not sex hormones or insulin resistance affects left ventricular mass in aging men.16145986
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin.16150198
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingTo explore the correlation of nonalcoholic fatty liver (NAFL) with insulin resistance and the intervention of it by Gankangyin(GKY).16150198
Burn Specimen Source Codes, Acinetobacter, Glucose Intolerance (disease)Deregulated Nutrient SensingAcinetobacter infection is associated with acquired glucose intolerance in burn patients.16151285
Burn Specimen Source Codes, Glucose Intolerance (disease)Deregulated Nutrient Sensingwas associated with the acquisition of glucose intolerance in burn patients.16151285
Communicable Diseases, Glucose Intolerance (disease)Deregulated Nutrient Sensinginfection were 9.8 times more likely to develop glucose intolerance than those without the infection (P < .0001).16151285
Communicable Diseases, Burn Specimen Source Codes, Glucose Intolerance (disease)Deregulated Nutrient Sensinginfection, 47% had glucose intolerance, compared with 12% in those with infection of the burn only (P = .03).16151285
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingStatins have been shown to significantly reduce morbidity and mortality both in patients with coronary artery disease and in those with dyslipidemia when they are taken regularly.16151763
Tumor necrosis, diabeticDeregulated Nutrient SensingThree measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients.16154427
diabeticDeregulated Nutrient SensingIn contrast, insulin resistance was not associated with TNF-alpha, nor sTNF-R (sTNF-R1 and sTNF-R2) in our diabetic patients.16154427
diabeticDeregulated Nutrient SensingFrom these results, it can be concluded that peripheral levels of TNF-alpha system activity are not a major factor responsible for insulin resistance in nonobese Japanese type 2 diabetic patients.16154427
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingDyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy.16156880
Dyslipidemias, Diabetes Mellitus, Smoking, AtherosclerosisDeregulated Nutrient SensingSmoking, dyslipidemia, diabetes, and age were all found to increase the degree of atherosclerosis (p < 0.01 to 0.05).16162761
DyslipidemiasDeregulated Nutrient SensingTreatment with high-dose simvastatin reduces secretion of apolipoprotein B-lipoproteins in patients with diabetic dyslipidemia.16162940
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHMG-CoA reductase inhibitors (statins) are effective lipid-altering drugs for the treatment of dyslipidemia in patients with type 2 diabetes mellitus.16162940
Dyslipidemias, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingMean age of the patients enrolled was 64 +/- 12 years; 69% are men, 26% have diabetes, 79% have dyslipidemia, and 72% have coronary artery disease (CAD) > or = 50%.16169331
Primary malignant neoplasmDeregulated Nutrient SensingSirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.16170353
Carcinoma of lung, Breast CarcinomaDeregulated Nutrient SensingHere, we show that Sirt1 inhibitor, Sirtinol, induced senescence-like growth arrest characterized by induction of senescence-associated beta-galactosidase activity and increased expression of plasminogen activator inhibitor 1 in human breast cancer MCF-7 cells and lung cancer H1299 cells.16170353
Sleep Apnea, ObstructiveDeregulated Nutrient SensingData on the effects of OSAS treatment with continuous positive airway pressure (CPAP) on blood glucose and insulin resistance are conflicting.16171273
Dyslipidemias, Coronary Artery Disease, Peripheral Vascular Diseases, Autonomic neuropathy, Hypertension, CTCAEDeregulated Nutrient SensingSerum C-peptide level was higher in patients with dyslipidemia (p = 0.045), hypertension (p = 0.001), coronary artery disease (p = 0.001), peripheral vascular disease (p = 0.001) and autonomic neuropathy (p = 0.001).16173326
Lipodystrophy, Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient SensingPatient 2 was a 24-yr-old Caucasian female with generalized lipodystrophy, hypertriglyceridemia, and severe insulin resistance diabetes who required more than 200 U of insulin daily.16174718
Apolipoprotein E, DyslipidemiasDeregulated Nutrient SensingThe objective of this work was to study the distribution of apolipoprotein E (APOE) genotypes in a sample of the Portuguese population, and its association with the dyslipidemias observed.16176168
AtherosclerosisDeregulated Nutrient SensingPlasma adiponectin is associated with insulin resistance and atherosclerosis.16179286
Hyperlipidemia, Diabetes MellitusDeregulated Nutrient SensingPlasma lipids were measured in 17 subjects, 16 of whom had hyperlipidemia and 14 presented with either documented insulin resistance or diabetes mellitus.16181372
Alzheimers DiseaseDeregulated Nutrient SensingConnective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology.16186174
Non-insulin Hypoglycemic, "Alzheimers Disease", Data types - Address, Diabetes MellitusDeregulated Nutrient SensingThe goal of this study was to further explore potential mechanisms through which diabetogenic dietary conditions that result in promotion of insulin resistance (IR), a feature of non-insulin dependant diabetes mellitus (type-2 diabetes), may influence Alzheimer's disease (AD).16186174
GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingACS was associated with insulin resistance and increased levels of specific insulin, proinsulin, and high proinsulin-to-insulin ratios.16186285
ObesityDeregulated Nutrient SensingIn stratified analyses, this CRP-diabetes association was stronger in subjects without obesity or other risk factors related to insulin resistance and in nondrinking subjects.16186286
Obesity, Diabetes MellitusDeregulated Nutrient SensingOur findings suggest that elevated CRP concentration is a significant predictor of diabetes in the general Japanese population, independent of obesity and insulin resistance.16186286
Choline Dehydrogenase, Mitochondrial, Hypertriglyceridemia, Dyslipidemias, diabeticDeregulated Nutrient SensingDyslipidemia contributes significantly to CHD in diabetic patients, in whom lipid abnormalities include hypertriglyceridemia, low HDL cholesterol, and increased levels of small, dense LDL particles.16186406
Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.16186408
Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD).16186408
Vertigo, Peripheral, Tinnitus, Dyslipidemias, Depression, CTCAE, Hypertension, CTCAEDeregulated Nutrient SensingIn multivariable analysis, only female sex, self-reported depression, tinnitus, hypertension, and dyslipidemia had an independent effect on vestibular vertigo.16186531
Insulin resistance syndromeDeregulated Nutrient SensingNo comparable associations were found with other traits of the insulin-resistance syndrome (e. g.; body mass index, waist to hip ratio).16189801
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo present a retrospective analysis of the effects of human U-500 insulin in 20 patients with type 2 diabetes and insulin resistance.16191489
Nonalcoholic Steatohepatitis, Prostate Cancer Outcomes Study, Weight decreased, Polycystic Ovary Syndrome, Fatty Liver DiseaseDeregulated Nutrient SensingTo report a case of biopsy-documented nonalcoholic steatohepatitis (NASH), which improved appreciably through moderate exercise and weight loss in a young woman with polycystic ovary syndrome (PCOS) and insulin resistance.16191492
Prostate Cancer Outcomes Study, Fatty Liver DiseaseDeregulated Nutrient SensingIn addition, we review the recent literature regarding the association of insulin resistance with NASH and PCOS.16191492
Hyperlipidemia, dysmetabolic syndrome, Prostate Cancer Outcomes Study, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWomen with PCOS and insulin resistance have an increased risk of developing many of the consequences of the dysmetabolic syndrome, including type 2 diabetes, hypertension, and hyperlipidemia.16191492
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis.16192263
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingObese people are at high risk for developing diabetes, dyslipidemia, hypertension, and cardiovascular diseases, which lead to an increased risk of mortality.16194025
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity was found in 56%, hypertension in 29%, dyslipidemia in 54%, diabetes in 24%, smoking history in 82%, and habitual physical activity in 13% in young patients.16195612
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPeroxisome proliferator-activated receptors (PPARs) present a therapeutic target, and simultaneous activation of PPAR-alpha and PPAR-gamma may provide improvements in glycemic control and dyslipidemia in patients with type 2 diabetes.16199244
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIn a predominantly low income population and without continuous assistance from the State to purchase statins, the achievement of preconized objectives for LDL-cholesterol, by 3rd Guidelines on Dyslipidemia of Brasilian Society of Cardiology, is low and also significantly lower among very old patients, with a high risk profile for atherosclerosis.16200261
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular Disease and a family history of dyslipidemia were present in 55 & 60% of the samples, respectively.16205024
Dyslipidemias, Family historyDeregulated Nutrient SensingA family history of dyslipidemia, an elevated LDL-C level, and a high FH score exhibited a statistically significant association with mutations.16205024
Dyslipidemias, Family historyDeregulated Nutrient SensingLDL-R gene mutation was significantly associated with family history of dyslipidemia, LDL-C Level and FH score.16205024
Glucose Intolerance (disease), Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingDeceleration time was shortened with a worsening degree of glucose intolerance in all the patients (P=0.0005), in those with left ventricular hypertrophy (P=0.0006) and in those without left ventricular hypertrophy (P=0.033).16205440
Hypertensive (finding), Glucose Intolerance (disease)Deregulated Nutrient SensingIn hypertensive patients, left ventricular diastolic function is determined by left ventricular mass index and the status of preclinical glucose intolerance, independent of age, gender, race, body mass index, blood pressure level, nocturnal drop in blood pressure or lipid level.16205440
Diabetes MellitusDeregulated Nutrient SensingInfluence of glucose control and improvement of insulin resistance on microvascular blood flow and endothelial function in patients with diabetes mellitus type 2.16207627
Inflammation, ObesityDeregulated Nutrient SensingThe significant association of severe obesity in nondiabetic and normotensive patients suggests that other obesity-associated mechanisms such as insulin resistance and inflammation should be further explored.16209988
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia among black patients with type 2 diabetes.16211122
DyslipidemiasDeregulated Nutrient SensingThe total number of patients with diabetic dyslipidaemia (DD) was 56 (90.3%).16211122
Dyslipidemias, ObesityDeregulated Nutrient SensingLonger TV viewing (>14 h per week) was associated with an increased risk of insulin resistance, obesity and dyslipidaemia in both men and women.16211373
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus.16212119
Diabetes MellitusDeregulated Nutrient SensingRecently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogenesis of obesity-related insulin resistance, but its relevance to human diabetes remains uncertain.16212119
Overweight, diabeticDeregulated Nutrient SensingTherefore, we assessed the relationship between serum resistin concentrations and insulin resistance in lean, overweight and obese (OW/OB) non-diabetic and diabetic Saudi women.16212119
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingResistin concentrations are elevated in patients with type 2 diabetes and are associated with obesity and insulin resistance.16212119
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingA case control study was conducted within the prospective cohort of the Insulin Resistance Atherosclerosis Study: 26 cases who developed type 2 diabetes in the follow-up period and 26 controls who remained free of type 2 diabetes were randomly selected.16222068
diabeticDeregulated Nutrient SensingStepwise regression analyses showed that body mass index or insulin resistance index was the major factor determining plasma esRAGE in all, nondiabetic or diabetic population.16224056
Tuberous xanthoma, DyslipidemiasDeregulated Nutrient SensingHe subsequently developed refractory dyslipidemia, palmar crease, and tuberous xanthomas.16227109
Acute myocardial infarction, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance is associated with a high incidence of left ventricular (LV) dysfunction after acute myocardial infarction (AMI).16229911
Autonomic neuropathy, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients with SMI were older and had a higher prevalence of autonomic neuropathy, hypertension, and dyslipidemia than those without.16230776
diabeticDeregulated Nutrient SensingImpaired nonoxidative glucose disposal and decrease in mitochondrial glucose oxidation both contribute to insulin resistance in diabetic subjects.16234307
Proteinuria, Edema, Diabetic Retinopathy, Glucose Intolerance (disease), Chronic Kidney DiseasesDeregulated Nutrient SensingHere, we present three patients with edema, heavy proteinuria, chronic renal failure, in whom no past or present symptomatic glucose intolerance or diabetic retinopathy were found.16240902
Dyslipidemias, Kidney Diseases, ObesityDeregulated Nutrient SensingSpecific population characteristics (high prevalences of central obesity, dyslipidaemia, renal disease) may make the WHO definition preferable to the ATPIII definition in these population groups.16241926
LMNA wt Allele, DyslipidemiasDeregulated Nutrient SensingThis case demonstrates the benefits of PPARgamma-agonists on glycaemic control and dyslipidaemia in a patient with FPLD.16241930
Diabetes MellitusDeregulated Nutrient SensingFor non-diabetic men and women, the body size factor (body size/insulin resistance factor for men) was strongly associated with diabetes incidence (OR=2.30, 95% CI 1.41-3.74 and OR=2.06, 95% CI 1.33-3.17, respectively).16242698
Coronary heart diseaseDeregulated Nutrient SensingCross-sectional associations of resistin, coronary heart disease, and insulin resistance.16249281
Metabolic Syndrome XDeregulated Nutrient SensingMetabolic syndrome may not capture all the CVD risk associated with insulin resistance.16249452
Obesity, AtherosclerosisDeregulated Nutrient SensingFree fatty acids are associated with obesity, insulin resistance, and atherosclerosis in renal transplant recipients.16249742
AtherosclerosisDeregulated Nutrient SensingInsulin resistance (IR) may be implicated in the pathogenesis of atherosclerosis in renal transplant recipients (RTRs) and be contributed to, in part, by free fatty acids (FFAs), produced in excess in centrally obese individuals.16249742
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOur data indicate that young asymptomatic male smokers tend to have hypertension, dyslipidaemia and increased production of free oxygen radicals, perhaps by attenuation of oxidative stress by cigarette smoking.16251776
Dyslipidemias, Kidney FailureDeregulated Nutrient SensingEpidemiological studies suggest that dyslipidemia is an independent risk factor for the development of renal insufficiency in otherwise healthy individuals.16253720
Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingThis study suggests that arterial changes occur early in the course of renal disease progression and may be related to dyslipidemia in the early stages.16253725
Dyslipidemias, Depressed mood, HepatomegalyDeregulated Nutrient SensingCESD patients present in childhood with hepatomegaly and dyslipidemia characterized by elevated total and low-density lipoprotein cholesterol (LDL-C), with elevated triglycerides and depressed high-density lipoprotein cholesterol (HDL-C).16255772
Dyslipidemias, ObesityDeregulated Nutrient SensingChanging relationships of obesity and dyslipidemia in Greek children: 1982-2002.16256184
ObesityDeregulated Nutrient SensingALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance.16261187
Inflammation, Obesity, AtherosclerosisDeregulated Nutrient SensingInflammation in adipose tissue may link obesity to insulin resistance and atherosclerosis.16261187
ObesityDeregulated Nutrient SensingWe investigated ALOX5AP expression in adipose tissue, and association of gene polymorphisms with obesity and insulin resistance.16261187
ObesityDeregulated Nutrient SensingALOX5AP haplotypes that associate with CVD are not associated with obesity or insulin resistance.16261187
ObesityDeregulated Nutrient SensingInvestigated ALOX5AP haplotypes are not major primary risk factors for obesity and insulin resistance.16261187
Dyslipidemias, Breast Carcinoma, ObesityDeregulated Nutrient SensingHigh levels of serum insulin and obesity often coexist with dyslipidemia in the insulin resistance syndrome (IRS), but the contribution of lipids to breast cancer outcome is unclear.16261412
AIRE wt Allele, Addison Disease, Hypothyroidism, Glucose Intolerance (disease), HypoparathyroidismDeregulated Nutrient SensingAPECED was suspected first because she developed progressively hypoparathyroidism, adrenocortical failure, glucose intolerance, and hypothyroidism.16263818
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingTo study the difference in prevalence of dyslipidemia, hypercholesterolemia, hypertriglyceridemia and low blood high-density lipoprotein cholesterol (HDL-C) between the residents of urban and rural areas of varied regions in China.16266538
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia has become one of important risk factors threatening health of Chinese people, with hypertriglyceridemia and low blood HDL-C as two major types in those aged 18 and over.16266538
DyslipidemiasDeregulated Nutrient SensingIt is very important to pay more attention to earlier comprehensive prevention and control of dyslipidemia.16266538
NeoplasmsDeregulated Nutrient SensingTumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.16269335
Primary malignant neoplasmDeregulated Nutrient SensingInactivation of HIC1 results in upregulated SIRT1 expression in normal or cancer cells; this deacetylates and inactivates p53, allowing cells to bypass apoptosis and survive DNA damage.16269335
Primary malignant neoplasmDeregulated Nutrient SensingSince aging increases promoter hypermethylation and epigenetic silencing of HIC1, we speculate that the resultant upregulation of SIRT1 may be a double-edged sword that both promotes survival of aging cells and increases cancer risk in mammals.16269335
Autosomal Recessive Disorder, Myeloid Leukemia, Chronic, Familial generalized lipodystrophyDeregulated Nutrient SensingCongenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near complete absence of adipose tissue since birth and insulin resistance.16269843
Hypertension, CTCAE, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingRecent changes in lifestyle and diet of Alaskan Eskimos, leading to obesity, hypertension, insulin resistance and DM, contribute to an increased risk for cardiovascular disease.16277121
Glucose Intolerance (disease), Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingCHD was significantly related to age, glucose intolerance and insulin.16277121
Glucose Intolerance (disease)Deregulated Nutrient SensingThis finding suggests that high consumption of C20-C22 omega-3 FAs protects against the development of the MS and glucose intolerance.16277123
Periodontal Diseases, ObesityDeregulated Nutrient SensingObesity is a significant predictor of periodontal disease and insulin resistance appears to mediate this relationship.16277579
Periodontal Diseases, ObesityDeregulated Nutrient SensingFurthermore, obesity is associated with high plasma levels of TNFalpha and its soluble receptors, which in turn may lead to a hyperinflammatory state increasing the risk for periodontal disease and also accounting in part for insulin resistance.16277579
Periodontal Diseases, Periodontal Infection, Obesity, Diabetes MellitusDeregulated Nutrient SensingFurther studies of the molecular basis of insulin resistance and its relationship to diabetes, periodontal disease, and obesity are necessary to fully test the hypothesis that adipocyte production of proinflammatory cytokines is a pathogenic factor linking obesity to diabetes and periodontal infections.16277579
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrescreening tools for diabetes and obesity-associated dyslipidaemia: comparing BMI, waist and waist hip ratio.16278693
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn men, BMI had a nonsignificantly higher sensitivity than waist or WHR for both diabetes and dyslipidaemia (77 vs 74 and 66% P<0.3, 0.09; 56 vs 54 and 49% P<0.5, 0.16).16278693
Cardiovascular DiseasesDeregulated Nutrient SensingIndividual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol.16280425
Alzheimers Disease", Data types - Address, Memory impairmentDeregulated Nutrient SensingInsulin resistance (impaired insulin action) has been associated with Alzheimer disease (AD) and memory impairment, independent of AD.16286438
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIn this large prospective cohort, atherogenic dyslipidemias were associated with the subsequent development of hypertension among healthy women.16287773
Primary malignant neoplasmDeregulated Nutrient SensingControl of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.16288004
Primary malignant neoplasmDeregulated Nutrient SensingCollectively, these findings uncovered a novel function for the longevity gene sirt1 as a potential target for diagnosis and/or treatment of cancer resistance to chemotherapy.16288004
Carcinogenesis, Colorectal CarcinomaDeregulated Nutrient SensingBecause both adiposity and insulin resistance have been associated with risk of colorectal cancer, we hypothesized that adiponectin is associated with colorectal carcinogenesis.16288122
Dyslipidemias, OverweightDeregulated Nutrient SensingEffects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia.16291982
Dyslipidemias, OverweightDeregulated Nutrient SensingSelective CB1-receptor blockade with rimonabant significantly reduces body weight and waist circumference and improves the profile of several metabolic risk factors in high-risk patients who are overweight or obese and have an atherogenic dyslipidemia.16291982
Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingRecording the presence of insulin resistance will aid the practitioner in determining if a low-risk patient is in peril for development of type 2 diabetes and/or CVD.16293162
Increased insulin levelDeregulated Nutrient SensingSince hyperinsulinemia is a hallmark of T2DM, it is important to verify that increased insulin production is not due to increased insulin resistance.16293352
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingIn these patients the most pronounced risk factors for CVD were dyslipidemia and hyperglycemia, which justify the need for the early detection of these factors as well as strict metabolic control.16296632
ObesityDeregulated Nutrient SensingIn conclusion, our data indicate that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism.16298335
Dyslipidemias, diabeticDeregulated Nutrient SensingIncreased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population.16298371
Diabetes MellitusDeregulated Nutrient SensingThese results suggest that higher apo C-III may contribute to the increased cardiovascular risk in subjects with insulin resistance and type 2 diabetes through its effects on triglycerides and LDL particle size.16298371
Glucose Intolerance (disease), Periodontal Diseases, Diabetes MellitusDeregulated Nutrient SensingIn addition, periodontal disease has been associated with development of glucose intolerance and poor glycemic control among adults with diabetes.16304554
Diabetes MellitusDeregulated Nutrient SensingOur hypothesis is that RAGE may be involved in the evolution of insulin resistance in addition to mediating glucotoxic complications of diabetes mellitus.16305072
Glucose Intolerance (disease), Polycystic Ovary SyndromeDeregulated Nutrient SensingRisk factors for glucose intolerance in Danish women with polycystic ovary syndrome.16305707
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Glucose Intolerance (disease)Deregulated Nutrient SensingWomen with polycystic ovary syndrome (PCOS) are reported to be at risk for glucose intolerance.16305707
Glucose Intolerance (disease)Deregulated Nutrient SensingAn OGTT may be necessary to find all cases of impaired glucose intolerance.16305707
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe Hertfordshire Cohort Study based in the U.K. was the first to report associations between fetal or infant growth and the prevalence of adult glucose intolerance and diabetes.16306332
Fatty Liver, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance, fatty liver, high serum leptin, hypertension, and acantosis nigricans were already evident in many slim prepubertal children.16306379
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was observed in 33 controls (33%) and 40 hypertensive patients (40%).16307156
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe present data indicate that dyslipidaemia affects a substantial proportion of healthy and hypertensive Congolese subjects.16307156
HypertrophyDeregulated Nutrient SensingWhen individual variations in six month changes were examined, participants attaining the greatest increases in fitness and reductions in abdominal fatness, insulin resistance and BP showed a modest trend towards physiological hypertrophy characterised by increased cardiac size and improved LV diastolic function.16308413
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe dyslipidemia of type 2 diabetic patients is characterized by high VLDL, abnormal LDL composition and low HDL cholesterol concentrations.16308886
Heat-Shock ResponseDeregulated Nutrient SensingInduction of heat shock proteins may combat insulin resistance.16309849
Vascular Diseases, Heat-Shock Response, Diabetes MellitusDeregulated Nutrient SensingMoreover, there is reason to believe that heat shock protein induction may have a favorable impact on the microvascular complications of diabetes, and on the increased risk for macrovascular disease associated with diabetes and insulin resistance syndrome.16309849
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with type 2 diabetes mellitus are at increased risk of cardiovascular disease, partly owing to dyslipidaemia, which can be amenable to fibrate therapy.16310551
Increased insulin level, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAlthough the prevalence of insulin resistance (IR) and compensatory hyperinsulinemia (CH) is increased in patients with nonalcoholic fatty liver disease, the role of IR/CH in regulation of hepatic fat content in healthy volunteers with normal concentrations of alanine transaminase (ALT) has not been defined.16311087
AtherosclerosisDeregulated Nutrient SensingPeroxisome proliferator-activated receptor (PPAR)gamma is involved mainly in adipocyte differentiation and has been suggested to play an important role in the pathogenesis of insulin resistance and atherosclerosis.16314192
Heart Diseases, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThirty percent had developed heart disease, hypertension, or dyslipidemia.16319262
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of garlic on dyslipidemia in patients with type 2 diabetes mellitus.16320801
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensingdyslipidemia in patients with type 2 diabetes mellitus.16320801
Dyslipidemias, diabeticDeregulated Nutrient SensingThis 12 week randomized, single-blind, placebo controlled study was conducted on Type 2 diabetic patients with newly diagnosed dyslipidemia (n=70).16320801
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study suggests possible small short term benefits of garlic on dyslipidemia in type 2 diabetic patients.16320801
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe findings show that the insulin resistance of PCOS is qualitatively different from that of type 2 diabetes.16322388
Hypertension, CTCAE, diabetic, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAmong diabetic patients, the presence of severe diabetes (as defined by the coexistence of hypertension, dyslipidaemia and insulin treatment) was significantly associated with SH (adjusted odds ratio, 3.8; 95% confidence interval, 1.4-10.2; P = 0.017).16322389
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim of this study is to evaluate the factors contributing to increasing glucose intolerance after onset of type 2 diabetes in Japanese subjects.16324919
Inflammation, HyperhomocysteinemiaDeregulated Nutrient SensingHyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children.16324922
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingObesity is an independent risk factor for the development of cardiovascular disease frequently associated with hypertension, dyslipemia, diabetes, and insulin resistance.16324922
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe mutations of 3394 (T-->C) and 14693 (A-->G) may contribute to the genetic predisposition to type 2 diabetes; 16189 (T-->C) variant is associated with insulin resistance and risk factor of diabetes.16331560
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes.16334613
Hypertension, CTCAE, Kidney Diseases, Obesity, Diabetes MellitusDeregulated Nutrient SensingRisk factors significantly associated with renal disease were age [P=0.018; odds ratio (OR) 2.7], hypertension (P=0.023; OR 2.13), pulse pressure (P=0.04; OR 0.10), diabetes mellitus (P=0.08; OR 4.48), obesity (P=0.000; OR 7.7), and insulin resistance index (P=0.04; OR 4.95).16336570
Hepatobiliary DisorderDeregulated Nutrient SensingPotential role of interleukin-18 in liver disease associated with insulin resistance.16339124
Hepatobiliary Disorder, ObesityDeregulated Nutrient SensingInterleukin (IL)-18 has been associated with obesity and insulin resistance, both risk factors for the development of liver disease, but the role of IL-18 in liver disease associated with insulin resistance is presently unknown.16339124
Hepatobiliary DisorderDeregulated Nutrient SensingIL-18 could contribute to the development of liver disease associated with insulin resistance.16339124
DyslipidemiasDeregulated Nutrient SensingLLT at discharge was positively associated with a previous medical history of dyslipidemia (P<0.001), lipid testing (P=0.004), and elevated low-density lipoprotein levels (P<0.001).16339479
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe also demonstrated that serum MDA levels of the patients with and those without hypertension (p = 0.846), diabetes mellitus (p = 0.891), or dyslipidemia (p = 0.38) were not significantly different.16340171
Kidney TransplantationDeregulated Nutrient SensingBecause insulin resistance plays a significant role in the development of PTDM, we treated 40 consecutive patients with PTDM after liver and kidney transplantation with the insulin sensitizer rosiglitazone (ROSI).16340782
Weight decreasedDeregulated Nutrient SensingImprovements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes.16352858
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingThe potential for early vasculopathy in individuals exposed to intermediate dose irradiation suggests a need to manage dyslipidemia and reduce vascular risk factors throughout the posttreatment period.16353211
Klinefelter Syndrome, Hypogonadism, Primary hypogonadism, Deficiency of testosterone biosynthesisDeregulated Nutrient SensingIn contrast, increased insulin resistance was found in both hypergonadotropic and hypogonadotropic men with hypoandrogenism, patients with Klinefelter's syndrome and men with idiopathic gonadotropin deficiency.16353672
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is considered to be one of the cornerstones in the state that ultimately leads to clinically established type 2 diabetes mellitus.16353672
HypogonadismDeregulated Nutrient SensingTherefore, supplementation with testosterone might play a role in improving both insulin resistance and hypogonadism.16353672
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe mechanisms by which testosterone causes insulin resistance is unknown, and larger studies on androgen treatment in type 2 diabetic patients are necessary.16353672
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.16356084
Glucose Intolerance (disease)Deregulated Nutrient SensingIncreased plasma levels of thioredoxin in patients with glucose intolerance.16357448
Glucose Intolerance (disease), Coronary Artery DiseaseDeregulated Nutrient SensingThe aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD).16357448
Glucose Intolerance (disease), Demographics DomainDeregulated Nutrient SensingIn multivariate logistic regression analysis, glucose intolerance (DM or IGT) was only independently associated with the high levels of thioredoxin.16357448
Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance was associated with the high levels of thioredoxin.16357448
Hypertensive (finding), diabeticDeregulated Nutrient SensingIt has been suggested that insulin resistance is involved in the impaired vascular endothelial function not only in diabetic patients but also in hypertensive patients.16364837
Hypertensive (finding), Endothelial dysfunctionDeregulated Nutrient SensingThe present study assessed the hypothesis that primary treatment of insulin resistance may reverse endothelial dysfunction in hypertensive subjects.16364837
Increased insulin level, Hypertensive (finding), HyperglycemiaDeregulated Nutrient SensingThe present findings demonstrate that pioglitazone improves endothelial function in nondiabetic hypertensive individuals with insulin resistance, and that the improvement is associated with the amelioration of insulin resistance itself rather than that of hyperglycemia or hyperinsulinemia.16364837
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingTherapeutic goal attainment in patients with hypertension and dyslipidemia.16365611
Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingWe sought to ascertain treatment patterns and attainment of therapeutic goals in patients with isolated and concomitant hypertension and dyslipidemia, both with and without diabetes mellitus (DM) and symptomatic cardiovascular disease.16365611
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingLow HDL-cholesterol and hypertriglyceridaemia are, therefore, common among European patients treated for dyslipidaemia.16368042
Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrevalence of diabetes, hypertension, dyslipidemia, and heart failure (HF) was higher in obese patients.16368306
AtherosclerosisDeregulated Nutrient SensingAdiponectin, an adipocyte-derived hormone is implicated in insulin resistance and atherosclerosis.16369465
Prediabetes syndrome, Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingWe conclude that decreased plasma adiponectin and insulin resistance coexist in subjects with prediabetes, diabetes and atherosclerosis.16369465
AtherosclerosisDeregulated Nutrient SensingAdiponectin concentration is an independent correlate of insulin resistance and atherosclerosis.16369465
Endothelial dysfunctionDeregulated Nutrient SensingThese interrelationships might amplify insulin resistance and endothelial dysfunction.16369774
Ventricular FibrillationDeregulated Nutrient SensingInsulin resistance was reversed by exercise (40.1 +/- 7.7 vs. 27.6 +/- 5.6 units, P < 0.01) and correlated with changes in VF (r = 0.66, P < 0.01) and maximal oxygen consumption (r = -0.48, P < 0.05) but not adipocytokines.16373444
Dyslipidemias, Chest PainDeregulated Nutrient SensingA moderate, but useful, increase in detection rates of dyslipidaemia is possible if lipid testing is offered to all patients presenting with chest pain, and not just to those who are admitted to wards for further investigation and management of suspected acute coronary syndromes.16373798
HypercholesterolemiaDeregulated Nutrient SensingRelationship between insulin resistance and lipid peroxidation and antioxidant vitamins in hypercholesterolemic patients.16373994
Increased insulin levelDeregulated Nutrient SensingSeveral studies have reported that insulin resistance and compensatory hyperinsulinemia increased lipid peroxidation, suggesting the linking to each other.16373994
HypercholesterolemiaDeregulated Nutrient SensingWe investigated the relationships between insulin resistance index HOMA-IR and lipid peroxidation, plasma antioxidant status in non-diabetic, hypercholesterolemic patients.16373994
HypercholesterolemiaDeregulated Nutrient SensingOur data showed that the insulin resistance of hypercholesterolemic patients increased oxidative stress and negatively influenced plasma antioxidant system.16373994
Glucose Intolerance (disease), Electrocardiogram: myocardial infarction (finding), Diabetes MellitusDeregulated Nutrient SensingIn conclusion, UAE was significantly and positively associated with cIMa in both the common carotid and the brachial arteries as well as with left ventricular septum thickness and glucose intolerance in patients with a history of previous myocardial infarction without known diabetes mellitus.16374441
Steatohepatitis, Fibrosis Assessment, Fatty degeneration, Hepatitis CDeregulated Nutrient SensingInsulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C. Conflicting data exist regarding the relationship between hepatitis C virus genotype 1 and hepatic steatosis as well as the latter's role in the progression of fibrosis and treatment response.16374856
DyslipidemiasDeregulated Nutrient SensingThe -1131T-->C polymorphism of the apolipoprotein A-V gene (APO A-V) is tightly linked to lipid metabolism and has been associated with increased triglyceride levels and familial dyslipidemia.16375582
Dyslipidemias, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia treatment dramatically decreases coronary heart disease risk in diabetes, yet only a minority of these patients are screened or achieve optimal low-density lipoprotein (LDL) cholesterol levels.16378790
Dyslipidemias, diabeticDeregulated Nutrient SensingBrief educational detailing either through direct or electronic communication favorably impacts provider behavior regarding dyslipidemia care for diabetic patients.16378790
ADIPOQ protein, human, AcromegalyDeregulated Nutrient SensingThe results suggest that adiponectinemia does not directly affect development of insulin resistance in acromegaly.16379314
Glucose Intolerance (disease), Coronary Artery DiseaseDeregulated Nutrient SensingPatients with coronary artery disease (CAD) have relatively low adiponectin levels and high prevalence of glucose intolerance.16381996
Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingIt has not been established firmly whether dyslipidemia contributes independently to the progression of kidney disease.16382017
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRoutine laboratory data and total Hcy were recorded, as well as the history of diabetes, hypertension, dyslipidemia, and overweight.16382457
Mitochondria, Diabetes MellitusDeregulated Nutrient SensingRecent evidence points toward mitochondrial aberrations as a major contributor to the development of insulin resistance and diabetes, and UCP3 is reduced in diabetes.16384852
Behavior DisordersDeregulated Nutrient SensingOur recent observations have indicated that insulin resistance could, at least in part, account for the pathogenesis of lifestyle-related diseases.16385239
Behavior DisordersDeregulated Nutrient SensingIn addition to insulin resistance syndrome, alcohol-related diseases should be cared to address the issues of lifestyle-related diseases.16385239
Diabetes Mellitus, Insulin-Dependent, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingClinical use of the lag plot is illustrated in seven case studies spanning the range from no diabetes, through glucose intolerance, early-onset type 2 diabetes mellitus, type 1 diabetes, intensified therapy, pump therapy, and finally islet cell transplantation.16386092
palladium, Dyslipidemias, Mental disorders, Diabetes MellitusDeregulated Nutrient SensingConcomitant diseases and medical comorbidities such as diabetes, dyslipidemia, psychological disorders and the presence of at least one risk factor were significantly associated with PD in patients with ED.16386353
Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingVariables considered risk factors were obesity (BMI >25), dyslipidemia, hypertension, prior thoracic surgery, diabetes, and history of ischemic heart disease.16386612
Weight Gain, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and weight gain secondary to lifestyle changes in living renal transplant donors.16387071
Hyperglycemia, Prostate carcinomaDeregulated Nutrient SensingHyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy.16388523
Hyperglycemia, Structure of posterior cerebral artery, Cardiovascular DiseasesDeregulated Nutrient SensingThe current data suggested that men with PCa who are receiving long-term ADT are at risk for developing insulin resistance and hyperglycemia, thus leading to their increased risk of cardiovascular disease.16388523
Hyperparathyroidism, Primary, HypophosphatemiaDeregulated Nutrient SensingHypophosphatemia is associated with impaired glucose tolerance and insulin resistance in primary hyperparathyroidism.16391583
DyslipidemiasDeregulated Nutrient SensingDo eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia?16392769
DyslipidemiasDeregulated Nutrient SensingThus, this preliminary study suggested that eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia.16392769
Increased insulin level, Coronary ArteriosclerosisDeregulated Nutrient SensingDevelopment and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia.16392771
Microunit per MilliliterDeregulated Nutrient SensingThe presence of insulin resistance was defined according to the guidelines reported our previous study: insulin levels of 64.0 mU/l or higher 2 h after the 75 g-OGTT.16392771
Coronary Artery DiseaseDeregulated Nutrient SensingThe results suggested that insulin resistance is an independent risk factor for coronary artery disease in Japanese subjects, as has also been demonstrated in the case of individuals in Europe and USA.16392771
Ventricular Dysfunction, Left, Coronary heart diseaseDeregulated Nutrient SensingAssociation between insulin resistance and impaired cardiac fatty acid metabolism may contribute to left ventricular dysfunction in patients with maintenance hemodialysis without coronary diseases.16395255
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingElevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance.16395259
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingWe also investigate possible links with inflammation and the insulin resistance present in patients with chronic kidney disease (CKD).16395259
Chronic Kidney Diseases, Dyslipidemias, Anemia, Hypertension, CTCAEDeregulated Nutrient SensingIn the tertiary care of CKD, treatment of hypertension is largely inadequate, whereas therapy of anemia and dyslipidemia is frequently omitted.16395261
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance is an established risk factor for CHD in the general population.16395749
Lupus Erythematosus, SystemicDeregulated Nutrient SensingInsulin resistance in the context of SLE was not strongly related to current or recent steroid therapy; it was, however, associated with higher levels of ox-LDL.16395749
Choline Dehydrogenase, Mitochondrial, Lupus Erythematosus, SystemicDeregulated Nutrient SensingInsulin resistance may therefore represent an additional CHD risk factor in patients with SLE.16395749
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance/compensatory hyperinsulinemia predict carotid intimal medial thickness in patients with essential hypertension.16399488
Hypertension, CTCAEDeregulated Nutrient SensingTo test this hypothesis, we attempted to see if there was a link between insulin resistance (IR) and carotid intimal medial thickness (IMT), an early index of CVD, in patients with essential hypertension.16399488
Primary malignant neoplasmDeregulated Nutrient SensingCentral and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens.16399897
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAlthough statin therapy improves cardiovascular risk in diabetes, dyslipidaemia in diabetes may be more responsive to combined statin and fibrate therapy.16401310
Diabetes MellitusDeregulated Nutrient SensingHowever, in Caucasian-Brazilians, the 1888A allele was significantly associated with diabetes (12.3% in patients vs. 3.5% in control subjects; OR=3.881; 95% CI 2.106-7.164; P<0.001) and also with higher levels of insulin resistance.16401312
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe present study indicates the association of the mitochondrial G1888A variant with Type 2 diabetes and insulin resistance in Caucasian-Brazilian patients from southern Brazil.16401312
Sleep Apnea, ObstructiveDeregulated Nutrient SensingObstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance.16402923
diabeticDeregulated Nutrient SensingTwenty-one patients undergoing diabetic treatments (two mild, nine moderate and 10 severe) were excluded from the assessment of insulin resistance and plasma adiponectin measurements.16402923
ObesityDeregulated Nutrient SensingSleep-disordered breathing was associated with insulin resistance independent of obesity.16402923
Sleep-Disordered Breathing, Sleep Apnea, Obstructive, ObesityDeregulated Nutrient SensingAlthough treatment of sleep-disordered breathing with nasal continuous positive airway pressure reportedly improves insulin sensitivity, our findings suggest that treatment of obesity is also essential in ameliorating insulin resistance at least through increased plasma adiponectin levels in OSAS.16402923
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia is an important, modifiable CHD risk factor.16404837
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia increased with advancing age and increasing BMI; notwithstanding, a high prevalence of dyslipidemia was observed in the youngest tertile as well.16404837
Inflammation, Demographics Domain, Dyslipidemias, Kidney Diseases, Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia and inflammation may promote renal disease via mechanisms of vascular endothelial cell dysfunction in type II diabetes mellitus (DM).16408124
Fatty Liver DiseaseDeregulated Nutrient SensingBoth conditions (NAFL and NASH) occur in the setting of peripheral insulin resistance.16416185
Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingRecently, obstructive sleep apnea (OSA) has been proposed as an independent risk factor for insulin resistance.16416185
SteatohepatitisDeregulated Nutrient SensingGreater insulin resistance can result in more severe hepatic steatosis among group B patients, leading to an overproduction of reactive oxygen species, which may accelerate telomere erosion.16420506
Cardiovascular morbidity, DyslipidemiasDeregulated Nutrient SensingHowever, increased cardiovascular morbidity and dyslipidaemia have also been recognized in mild pHPT, which also seem to be normalized after parathyroidectomy.16420548
Hypercholesterolemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing11.2 dollars for high blood pressure, 3.8 dollars for diabetes, and 30.6 dollars for dyslipidemia (using generic drugs except for hypercholesterolemia).16423280
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, serum adiponectin was lowered in women with type 2 diabetes mellitus, and this difference could only be partly explained by insulin resistance, insulin secretion, family history of diabetes, and inflammation.16423625
Diabetes Mellitus, Non-Insulin-Dependent, MS geneDeregulated Nutrient SensingThis study demonstrates that increased levels of sP-selectin and sCD40L are seen in Asian Indian subjects with IGT, type 2 diabetes mellitus, MS, and insulin resistance.16423632
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingMice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis.16423904
HypertriglyceridemiaDeregulated Nutrient SensingEvaluation of insulin resistance was made through the HOMA, QUICKI and McAuley indices and the triglycerides/high density lipoprotein (HDL) cholesterol ratio.16428124
Hepatitis, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingAs would be expected, hypertension, dyslipidaemia, diabetes and heart disease were the most common comorbidities; renal failure and hepatitis were least likely.16428152
ObesityDeregulated Nutrient SensingOther features of FCH are obesity and insulin resistance.16432543
Obesity, AtherosclerosisDeregulated Nutrient SensingSerum leptin levels have also been associated with obesity, insulin resistance and atherosclerosis.16432543
ObesityDeregulated Nutrient SensingA difference in high-density lipoprotein cholesterol (HDL-c) levels was present between carriers and non-carriers of an Arg allele, 1.21 vs 1.28 mmol/l, respectively (P=0.04), but no differences in obesity, insulin resistance and other lipid parameters were found.16432543
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, ObesityDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is associated with menstrual and reproductive abnormalities, insulin resistance, and obesity.16434451
Prostate Cancer Outcomes Study, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrevalence of PCOS and targeted cardiovascular risk factors [hypertension, dyslipidemia, diabetes mellitus, and body mass index (BMI)] were measured.16434451
Cholelithiasis, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingSerum insulin, insulin resistance, beta-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: a community-based study in Kinmen, Taiwan.16437664
Cholelithiasis, Beta-cell dysfunctionDeregulated Nutrient SensingTo explore the association of serum insulin, insulin resistance, and beta-cell dysfunction with gallstone disease (GSD) in type 2 diabetics.16437664
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingSerum insulin, insulin resistance, and beta-cell dysfunction are risk factors for GSD in females, but not males with type 2 diabetes.16437664
Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, TYMS wt Allele, Turner SyndromeDeregulated Nutrient SensingMild insulin resistance appears to be an early metabolic defect in girls with Turner syndrome (TS).16439845
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Tachycardia, VentricularDeregulated Nutrient SensingDyslipidemia is associated with ventricular tachyarrhythmia in patients with acute ST-segment elevation myocardial infarction.16440066
Tachyarrhythmia, DyslipidemiasDeregulated Nutrient SensingThis study suggests that dyslipidemia imposes a higher risk of developing tachyarrhythmia in the acute phase of STEMI.16440066
DyslipidemiasDeregulated Nutrient SensingRecent guidelines have targeted low-density lipoprotein (LDL) cholesterol for treatment of dyslipidemia.16442398
Mucoepidermoid CarcinomaDeregulated Nutrient SensingMucoepidermoid carcinomas (MECs) of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) translocation resulting in a MECT1-MAML2 fusion in which the CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2.16444749
Scoliosis, unspecified, Dyslipidemias, CLEFT LIP/PALATE WITH ABNORMAL THUMBS AND MICROCEPHALYDeregulated Nutrient SensingDysautonomia, dyslipidemia, and scoliosis were more frequent in VEDS patients than in JHS patients.16447226
Somatotropin deficiency, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingAn atherogenic lipid profile, insulin resistance, obesity, and increased body and trunk fat in GHD adults may cause the higher risk of cardiovascular disease in these patients.16449951
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, ObesityDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is associated with insulin resistance and a high incidence of obesity.16452543
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes, hypertension, and dyslipidemia in Mexican Americans and non-Hispanic whites.16459207
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAwareness of hypertension and dyslipidemia are significantly lower in Mexican Americans (57% vs 71% for hypertension, and 33% vs 56% for dyslipidemia).16459207
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingTreatment rates for hypertension and dyslipidemia are also significantly lower in Mexican Americans (42% vs 61% for hypertension; 14% vs 30% for dyslipidemia).16459207
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe significantly higher prevalence of diabetes in Mexican Americans, in contrast to hypertension and dyslipidemia, may sensitize healthcare providers to its detection and treatment.16459207
Gestational Diabetes, Diabetes MellitusDeregulated Nutrient SensingGDM mothers in urban India are more obese and more adipose than non-diabetic mothers, frequently have a family history of diabetes and show metabolic features of insulin resistance syndrome, suggesting high cardiovascular risk.16459528
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium.16461837
DyslipidemiasDeregulated Nutrient SensingBlack and Hispanic Americans had prevalence of dyslipidemia that was comparable to that of non-Hispanic whites but were less likely to be treated and controlled.16461837
DyslipidemiasDeregulated Nutrient SensingControl of dyslipidemia was achieved less commonly in the CVD high- and intermediate-risk groups than in the low-risk group.16461837
Glucose Intolerance (disease), Thalassemia, Diabetes MellitusDeregulated Nutrient SensingEvolution of glucose intolerance and diabetes in transfused patients with thalassemia.16462709
Depressed moodDeregulated Nutrient SensingWe propose that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver.16463046
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingElevated plasma glucose can further increase hepatic fat content through multiple pathways, resulting in overproduction of VLDL(1) particles and leading to the characteristic dyslipidaemia associated with type 2 diabetes.16463046
DyslipidemiasDeregulated Nutrient SensingThe effect of simvastatin on triglyceride-rich lipoproteins in patients with type 2 diabetic dyslipidemia: a SILHOUETTE trial sub-study.16466606
TG gene, DyslipidemiasDeregulated Nutrient SensingTo determine if simvastatin effectively decreases the elevated levels of triglyceride (TG), TG-rich lipoproteins, and small, dense LDL particles, which are characteristic of diabetic dyslipidemia.16466606
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe incidence of dyslipidaemias was of 61% with hypercholesterolaemia and hypertriglyceridaemia rates of 41% and 21%, respectively.16468265
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe role of dyslipidemia is essential in the development of atherosclerosis, therefore continuing care of dyslipidemic patients is an extremely important task in cardiovascular prevention.16468604
AtherosclerosisDeregulated Nutrient SensingTowards understanding of glycaemic index and glycaemic load in habitual diet: associations with measures of glycaemia in the Insulin Resistance Atherosclerosis Study.16469159
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPotatoes, a high glycemic form of carbohydrate, are hypothesized to increase insulin resistance and risk of type 2 diabetes.16469985
Hyperlipidemia, Fatty Liver DiseaseDeregulated Nutrient SensingFifty-four children diagnosed as NASH showed significantly higher incidence of hyperlipidemia, insulin resistance and higher body mass index as compared with 24 subjects without fatty liver changes.16470923
Fatty Liver DiseaseDeregulated Nutrient SensingSevere disturbance of lipid metabolism and insulin resistance may be involved in the mechanism of NASH.16470923
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThe patients had no history of myocardial infarction, coronary revascularisation, familial dyslipidaemia, diabetes or renal disease.16473514
Cardiovascular DiseasesDeregulated Nutrient SensingNumerous studies have shown that psychosocial stresses lead to the disturbance of the metabolism of lipids, insulin resistance and eventually to cardiovascular diseases.16480250
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of 'at least one risk factor' from the three major cardiovascular risk factors (hypertension, dyslipidaemia and diabetes) was also evaluated.16480535
Cardiac HypertrophyDeregulated Nutrient SensingMutations in the gene encoding the gamma2 subunit of AMP-activated protein kinase (PRKAG2) cause familial cardiac hypertrophy and electrophysiological abnormalities, with glycogen accumulation in the heart of affected patients.16487706
Dyslipidemias, Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is one of the main risk factors for atherosclerosis, usually the underlying cause of cardiovascular diseases which are the major cause of morbidity and mortality in developed countries.16487912
ObesityDeregulated Nutrient SensingInfluence of obesity and insulin resistance on left atrial size in children.16489973
Hypertrophy, ObesityDeregulated Nutrient SensingLeft atrial (LA) enlargement has been linked to obesity and insulin resistance in adults.16489973
Hypertrophy, Cardiovascular DiseasesDeregulated Nutrient SensingLA enlargement is present in childhood and is related to abdominal OB and insulin resistance, suggesting that children with central OB are at increased risk for cardiovascular disease.16489973
Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus and insulin resistance are associated with an increased risk of myocardial infarction (MI).16490431
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingSmoking should be stopped and hypertension, diabetes mellitus, dyslipidaemia and hypothyroidism treated.16492065
Endothelial dysfunction, diabeticDeregulated Nutrient SensingAdipocytokines are involved in the development of insulin resistance and endothelial dysfunction in diabetic patients.16492207
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlcohol use may confer increased risks not only of type 2 diabetes mellitus but also of preceding glucose intolerance status.16494963
TG gene, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingIt has been well established that dyslipidemia is a significant risk factor for coronary artery disease (CAD), however, the association between fasting triglyceride (TG) and the occurrence of CAD is controversial.16501284
Hypertension, CTCAE, Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingKidney transplant recipients are prone to hypertension, dyslipidemia, and cardiovascular death.16504676
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe associated SNPs and haplotype are the same as those observed to be associated with type 2 diabetes, insulin resistance, and fasting glucose in previous studies.16505227
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHaplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.16505254
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThus, the genes that encode the various AMPK subunits are intriguing candidates for the inherited basis of type 2 diabetes.16505254
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe therefore set out to test for the association of common variants in the genes that encode three selected AMPK subunits with type 2 diabetes and related phenotypes.16505254
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOf the seven genes that encode AMPK isoforms, we initially chose PRKAA2, PRKAB1, and PRKAB2 because of their higher prior probability of association with type 2 diabetes, based on previous reports of genetic linkage, functional molecular studies, expression patterns, and pharmacological evidence.16505254
ObesityDeregulated Nutrient SensingPlasminogen activator inhibitor 1 is thought to play a role in the pathogenesis of obesity and insulin resistance.16507937
Edema, diabeticDeregulated Nutrient SensingPioglitazone improved glycaemic control and inflammatory markers over 9 weeks but had no effect on microcirculatory variables associated with oedema or insulin resistance in type 2 diabetic patients treated with insulin.16508777
Glucose Intolerance (disease)Deregulated Nutrient SensingA recent study indicated that having deep pockets is significantly associated with past development of glucose intolerance in non-diabetic individuals using an oral glucose tolerance test (OGTT).16512753
GoutDeregulated Nutrient Sensing[Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)].16514819
GoutDeregulated Nutrient SensingTo evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR).16514819
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia associated with insulin resistance is an independent risk factor in the development of BPH.16516184
Increased insulin level, Dyslipidemias, Benign prostatic hypertrophyDeregulated Nutrient SensingHyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia.16516184
Increased insulin level, Metabolic Diseases, DyslipidemiasDeregulated Nutrient SensingPrevious studies have reported the association between hyperinsulinemia, dyslipidemia and BPH in patients with metabolic disorders like diabetes.16516184
Gall Bladder DiseasesDeregulated Nutrient SensingGallbladder disease is associated with insulin resistance in a high risk Hispanic population.16516330
Metabolic Syndrome XDeregulated Nutrient SensingGS is associated to insulin resistance, fatty liver and to metabolic syndrome, but not to serum CRP in a high risk Hispanic population.16516330
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingHigh levels of IL-6 are associated with hyperglycaemia, dyslipidemia and provoke insulin resistance.16518702
Ischemic cardiomyopathyDeregulated Nutrient SensingIn conclusion, high levels of IL-6 unmask the phenotypes (higher insulin resistance and zinc deficiency) in relation to the genotypes with subsequent risk of developing ischaemic cardiomyopathy in NIDDM-atherosclerotic patients carrying AA genotype.16518702
DyslipidemiasDeregulated Nutrient SensingThe study revealed that dyslipidemia is very common in type 2 diabetics and the most common abnormality seen was increased serum triglyceride levels (73.3%).16519073
Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe associated cardiovascular risk factors such as diabetes, hypertension, dyslipidemia, previous myocardial infarction and previous coronary artery bypass grafting/percutaneous transluminal coronary angioplasty were similar in both the groups.16521631
Hyperplastic PolypDeregulated Nutrient SensingRelationships between MP concentrations and parameters reflecting insulin resistance in patients were also studied.16523191
Apolipoproteins B, Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingSince adiponectin and chronic subclinical inflammation have been reported to predict the development of type 2 diabetes and since abnormalities in apolipoprotein B metabolism occur in the early course of insulin resistance, these findings may be compatible with the association between liver markers and risk of diabetes.16523413
Diabetes MellitusDeregulated Nutrient SensingThere is no certain evidence about the incidence of diabetes mellitus under the influence of corticosteroids, due to increase of hepatic glucose production, insulin resistance and exhaustion of pancreatic beta-cells because of stimulated endogenous secretion.16526267
Hyperglycemia, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThe present findings suggest that compliance with clinical recommendations in primary care as a measure to retard complications in patients with type 2 diabetes should be improved, especially with regard to control of hyperglycaemia, hypertension and dyslipidemia.16529163
Nonalcoholic Steatohepatitis, Chronic liver disease, Fibrosis Assessment, Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic steatohepatitis (NASH) is common cause of chronic liver disease strongly associated with insulin resistance leading to fibrosis.16531962
Hypertensive (finding), Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is associated with high risk for cardiovascular disease and lipid management is arguably necessary, especially in hypertensive subjects.16532712
DyslipidemiasDeregulated Nutrient SensingUrgent strategies are required to prevent increasing levels of dyslipidaemia in Thailand, as well as to develop and promulgate treatment guidelines that incorporate locally-relevant risk prediction functions.16536111
Diabetes MellitusDeregulated Nutrient SensingCarotenoids may reduce the risk for diabetes mellitus, but little is known about the association of insulin resistance with serum carotenoids in non-diabetic subjects.16537987
AtherosclerosisDeregulated Nutrient SensingEfficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis.16538000
atheroscleroticDeregulated Nutrient SensingGlimepiride appears to improve insulin resistance and atherosclerotic disorders.16538000
Diabetes MellitusDeregulated Nutrient SensingHaemochromatosis subjects with diabetes exhibited further declines in acute insulin response to glucose, insulin resistance, or both.16538487
Obesity, Diabetes MellitusDeregulated Nutrient SensingDiabetes is usually associated with obesity and concomitant insulin resistance.16538487
Diabetes Mellitus, Non-Insulin-Dependent, Increased insulin level, Breast CarcinomaDeregulated Nutrient SensingThere is growing evidence of a link between type 2 diabetes and breast cancer, possibly through insulin resistance and/or hyperinsulinemia.16538527
Breast Carcinoma, Diabetes MellitusDeregulated Nutrient SensingFurther studies are required to better characterize the processes that link insulin resistance, diabetes and breast cancer.16538527
Rheumatoid Arthritis, NecrosisDeregulated Nutrient SensingAnti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis.16539824
Inflammation, Cardiovascular Diseases, Refractory anemias, Rheumatoid Arthritis, Endothelial dysfunctionDeregulated Nutrient SensingSystemic inflammation, insulin resistance, and endothelial dysfunction have been implicated in the development of cardiovascular disease in rheumatoid arthritis (RA).16539824
Refractory anemias, Endothelial dysfunctionDeregulated Nutrient SensingSince insulin resistance can promote endothelial dysfunction and anti-TNF-alpha blockade yield a rapid improvement of endothelial function, we have sought to assess whether TNF-alpha blockade may also result in a reduction of insulin serum levels and improvement of insulin resistance in RA patients who require this therapy because of severe and refractory disease.16539824
Refractory anemiasDeregulated Nutrient SensingOur study confirms a rapid beneficial effect of infliximab on insulin resistance and insulin sensitivity in RA patients treated periodically with this drug.16539824
ObesityDeregulated Nutrient SensingAlthough data suggest that physical activity is associated with decreased insulin resistance, recommendations for exercise training are not specific for age or level of obesity.16540829
Diabetes Mellitus, Non-Insulin-Dependent, Increased insulin level, Breast CarcinomaDeregulated Nutrient SensingEvidence suggests that women with type 2 diabetes may be at increased risk of breast cancer, possibly due to chronic exposure to insulin resistance and/or hyperinsulinemia.16541321
Diabetes Mellitus, Non-Insulin-Dependent, Breast CarcinomaDeregulated Nutrient SensingThese results support the possibility that insulin resistance or some other aspect of type 2 diabetes may promote breast cancer, and may further direct treatment and prevention strategies.16541321
NeoplasmsDeregulated Nutrient SensingBased on the observations that SIRT1 is upregulated in tumor cells, the hypothesis is that deregulation of SIRT1 expression may promote tumorigenesis by altering cellular signaling or by inducing modulation of chromatin remodeling leading to promotion of tumorigenesis.16546327
Hypertensive (finding), Damage, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidaemia, high plasma glucose levels, the duration of hypertension and being on antihypertensive therapy appear to be the main predictors of hypertensive cardiac damage.16547554
Inflammation, Hypertension, CTCAE, Diabetes Mellitus, Congestive heart failureDeregulated Nutrient SensingStepwise adjustment for inflammation, hypertension, insulin resistance, and diabetes mellitus did not decrease the relative risk of a greater waist circumference for the development of CHF (all HR=1.27-1.32, 95% CI=1.02-1.61 per SD increase).16551307
Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity, inflammation, insulin resistance and cardiovascular disease (CVD) risk are inter-related.16552404
Hypertension, CTCAE, AtherosclerosisDeregulated Nutrient SensingPhysical activity, insulin sensitivity, and hypertension among US adults: findings from the Insulin Resistance Atherosclerosis Study.16554349
Inflammation, Dyslipidemias, Heart failure, Coronary heart diseaseDeregulated Nutrient SensingRelationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease.16556684
Inflammation, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSerum adiponectin is associated with the presence of atherogenic dyslipidemia and with NT-proBNP concentration but not with markers of systemic inflammation in patients with manifest CHD.16556684
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThus, atherogenic dyslipidemia may link adiponectin with the progression of atherosclerosis.16556684
Dyslipidemias, Diabetes Mellitus, Coronary heart diseaseDeregulated Nutrient SensingAlthough small dense low-density lipoprotein (sd-LDL) has an established association with diabetic dyslipidemia, previous studies have failed to show an association between sd-LDL and diabetes among coronary heart disease patients.16565554
diabetic, AtherosclerosisDeregulated Nutrient SensingThe natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study.16567536
ObesityDeregulated Nutrient SensingInsulin resistance is promoted already in childhood by obesity and possibly by high-saturated fat intake.16567815
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingSex- and season-dependent differences in residual functional beta cell mass and/or insulin resistance have been identified at diagnosis of type 1 diabetes.16570164
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVisceral adipose tissue as an indicator of insulin resistance in nonobese patients with new onset type 2 diabetes mellitus.16570234
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and type 2 diabetes mellitus are characterized by insulin resistance.16570234
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe determined the relationship between insulin resistance and visceral adipose tissue (VAT) and their correlation with bioimpedance analysis in nonobese new onset type 2 diabetes patients.16570234
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was also found in a significant number of cases, mostly elevated LDL, low HDL and elevated Lp(a).16570759
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia correlating to insulin resistance is one of the key features in type 2 diabetes (T2D).16572495
ObesityDeregulated Nutrient SensingThis association is independent of obesity, insulin resistance, and the content of triglycerides within HDL particles.16574896
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIncreased serum uric acid (SUA) levels are linked to obesity, dyslipidemia, diabetes and hypertension.16575272
ObesityDeregulated Nutrient SensingWe speculate that the escalating prevalence of obesity and insulin resistance among adolescents might negatively influence male reproductive function for the next generation.16582411
Glucose Intolerance (disease), Fibrosis AssessmentDeregulated Nutrient SensingC282Y/H63D compound heterozygous individuals who had glucose intolerance had more severe fibrosis compared with those without glucose intolerance (1.0+/-1.0 vs. 0.1+/-0.3, P=0.01).16584391
Glucose Intolerance (disease), Fibrosis AssessmentDeregulated Nutrient SensingHowever, glucose intolerance may be important risk factor for the development of hepatic fibrosis in subjects with the C282Y/H63D HFE genotype.16584391
Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingWe studied in the Insulin Resistance Atherosclerosis Study the relation of incident diabetes to dynamic changes of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen.16585388
ObesityDeregulated Nutrient SensingHowever, its role in the treatment of insulin resistance and obesity in children and adolescents is less clearly defined.16595599
Primary malignant neoplasmDeregulated Nutrient SensingInhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.16596166
Primary malignant neoplasmDeregulated Nutrient SensingThe class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb gene silencing in Drosophila.16596166
Breast CarcinomaDeregulated Nutrient SensingIn contrast, inhibition of SIRT1 by pharmacologic, dominant negative, and siRNA (small interfering RNA)-mediated inhibition in breast and colon cancer cells causes increased H4-K16 and H3-K9 acetylation at endogenous promoters and gene re-expression despite full retention of promoter DNA hypermethylation.16596166
Primary malignant neoplasmDeregulated Nutrient SensingFurthermore, SIRT1 inhibition affects key phenotypic aspects of cancer cells.16596166
Diabetes MellitusDeregulated Nutrient SensingIn CARDIA, higher serum carotenoid concentrations are associated with lower risk of diabetes and insulin resistance in nonsmokers but not in smokers.16597706
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingAfter myocardial infarction carvedilol improves insulin resistance compared to metoprolol.16598518
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingWe compared effects of carvedilol and metoprolol on insulin resistance and serum lipid levels after myocardial infarction.16598518
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingIn patients after myocardial infarction, carvedilol added to background therapy improved insulin resistance and lipid profile.16598518
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingData on dyslipidemia in type 1 diabetes is scarce.16603826
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingGood management of diabetes seems to be of paramount importance in controlling dyslipidemia.16603826
Coronary Artery DiseaseDeregulated Nutrient SensingAttenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate.16606809
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingDevelopment of insulin resistance (IR) may be important in the pathogenesis of both metabolic syndrome and type 2 diabetes mellitus.16606809
Cessation of life, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingTo study the benefit of the therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (simvastatin) associated with diet in treating dyslipidemia in elderly patients, considering that they are more exposed to sudden death, myocardial infarction and stroke.16610166
Cessation of life, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingBased on the fact that dyslipidemia is a major, independent cardiovascular risk factor, we consider that therapy with hydroxymethylglutaryl coenzyme-A-reductase inhibitors is beneficial in elderly patients because of their efficacity, minimal side effects and protection against sudden death, myocardial infarction and stroke.16610166
HyperthyroidismDeregulated Nutrient SensingSerum levels of ghrelin and its relationship with insulin resistance were evaluated in 48 patients with hyperthyroidism and 43 euthyroid healthy controls.16612106
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingYKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance.16612564
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingYKL-40 participates in inflammatory states and vascular processes, which implies that comparison can be made with other inflammatory markers associated with insulin resistance and type 2 diabetes (T2D).16612564
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingYKL-40 and hsCRP are elevated in patients with T2D and are related to insulin resistance.16612564
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance is an important risk factor for coronary artery disease.16614503
Increased insulin level, No metabolic abnormalitiesDeregulated Nutrient SensingAlthough several observations suggest that insulin resistance/compensatory hyperinsulinemia (IR/CH) has a direct effect on endothelial function, independently of the metabolic abnormalities associated with the defect in insulin action, this relation has not been evaluated in apparently healthy individuals.16616036
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNone of the men had known history of diabetes or dyslipidemia.16617314
Increased insulin level, Glucose Intolerance (disease), DyslipidemiasDeregulated Nutrient SensingDevelopment of cookie test for the simultaneous determination of glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia.16618974
Increased insulin level, Glucose Intolerance (disease), DyslipidemiasDeregulated Nutrient SensingA new cookie test was developed for the simultaneous evaluation of multiple risk factors such as glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia.16618974
Increased insulin level, Postprandial hyperlactemiaDeregulated Nutrient SensingIn addition, hyperinsulinemia, insulin resistance (AUC insulin, and/or AUC insulin X AUC glucose), and postprandial hyperlipidemia (DeltaTG, Triglyceride; DeltaRLP, remnant like particles) have been simultaneously uncovered.16618974
Increased insulin level, Behavior Disorders, Diabetes Mellitus, Postprandial hyperlactemiaDeregulated Nutrient SensingIn 64 subjects with lifestyle-related diseases, cookie test revealed hyperinsulinemia and insulin resistance in 56% respectively, postprandial hyperlipidemia in 39%, diabetes and IGT in 22-23% of each of the subjects and all showed at least one abnormal value.16618974
Increased insulin level, Glucose Intolerance (disease), Postprandial hyperlactemiaDeregulated Nutrient SensingSimultaneous evaluation of glucose intolerance, hyperinsulinemia, insulin resistance, and postprandial hyperlipidemia was also possible.16618974
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe risk factors of hypertension, poor glycaemic control, dyslipidaemia and cigarette smoking were present in a fair proportion of the study patients.16619728
Metabolic Diseases, OverweightDeregulated Nutrient SensingInsulin resistance in Brazilian adolescent girls: association with overweight and metabolic disorders.16621110
OverweightDeregulated Nutrient SensingBrazilian overweight girls with higher insulin resistance had high risk of developing MS.16621110
TG gene, diabeticDeregulated Nutrient SensingOur study results suggest that PG suppresses increases in postprandial glucose and TG levels, and improves insulin resistance; and, in addition, that PG may have a favorable impact on oxidative stress in type 2 diabetic patients.16622303
Immunoglobulin M, Dyslipidemias, Blood GlucoseDeregulated Nutrient SensingPatients with IGM had more dyslipidemia, higher levels of fasting glycemia, triglycerides and urea and lower HDL cholesterol.16623355
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCardiovascular risk factors were found in a significant proportion of our sample (hypertension in 56.3%, diabetes mellitus in 38.0%, current or previous smoking in 51.4%, dyslipidemia in 67.6%).16623357
InflammationDeregulated Nutrient SensingIt has already been demonstrated that insulin resistance (IR) is associated with the stimulation of erythroid progenitors and with increased levels of inflammation markers.16628283
MicroalbuminuriaDeregulated Nutrient SensingThe systolic blood pressure, high sensitive C-reactive protein (hsCRP) and insulin resistance were independently related with microalbuminuria on the logistic regression analysis.16629224
MicroalbuminuriaDeregulated Nutrient SensingThese finding suggest that the systolic blood pressure, hsCRP and insulin resistance are the independent risk factors for microalbuminuria in normoglycemic, normotensive adults.16629224
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWaist and hip circumferences were both positively associated with the presence of hypertension, dyslipidemia, and diabetes.16631430
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHowever, after adjustment for BMI and age, hip circumference exhibited a significant dose-dependent inverse relationship with dyslipidemia and diabetes in women, but not men.16631430
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIncreasing adjusted waist circumference was associated with increased risk of hypertension and diabetes in Chinese and dyslipidemia in women only.16631430
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe value of u-ACR was significantly higher in patients with dyslipidemia (P<.001) but not in those with CA stenosis or hypertension.16632783
Chronic Kidney DiseasesDeregulated Nutrient SensingA drop of less than 10% from mean daytime values (nondipping) is associated with chronic kidney disease, insulin resistance, and cardiovascular events.16636209
Dyslipidemias, HyperlipoproteinemiasDeregulated Nutrient SensingAs such, in patients with type III hyperlipoproteinemia, it is essential to search for exacerbating factors, particularly because the amelioration of such factors may rectify the effects of the underlying dyslipidemia.16638727
Malignant neoplasm of endometriumDeregulated Nutrient SensingAssociation between adiponectin, insulin resistance, and endometrial cancer.16639730
Malignant neoplasm of endometriumDeregulated Nutrient SensingThe authors hypothesized that insulin resistance also contributes to an increased risk for endometrial cancer.16639730
Increased insulin levelDeregulated Nutrient SensingAdiponectin is a protein secreted by adipose cells and has been shown to be a surrogate marker for insulin resistance, with low levels of adiponectin correlated with hyperinsulinemia and degree of insulin resistance.16639730
Malignant neoplasm of endometriumDeregulated Nutrient SensingThis suggested that insulin resistance is independently associated with endometrial cancer.16639730
Endothelial dysfunctionDeregulated Nutrient SensingAssociation between insulin resistance and endothelial dysfunction in renal transplant recipients.16640526
Endothelial dysfunctionDeregulated Nutrient SensingEndothelial dysfunction is significantly associated with insulin resistance in normoglycemic RTR but explains a rather small part of the variation.16640526
Communicable DiseasesDeregulated Nutrient SensingBurden of infection and insulin resistance in healthy middle-aged men.16644637
Communicable Diseases, InflammationDeregulated Nutrient SensingWe hypothesized that burden of infection could be associated with chronic low-grade inflammation, resulting in insulin resistance.16644637
EnterovirusDeregulated Nutrient SensingPathogen burden showed the strongest association with insulin resistance, especially with enteroviruses and C. pneumoniae seropositivity.16644637
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and microalbuminuria: a cross-sectional, case-control study of 158 patients with type 2 diabetes and different degrees of urinary albumin excretion.16644705
MicroalbuminuriaDeregulated Nutrient SensingA role for insulin resistance in the pathogenesis of microalbuminuria has been suggested but is still unproven.16644705
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn type 2 diabetes, more severe insulin resistance is independently associated with microalbuminuria.16644705
MicroalbuminuriaDeregulated Nutrient SensingLongitudinal studies are needed to clarify the role of insulin resistance in the pathogenesis of microalbuminuria and related complications.16644705
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingVariants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.16644716
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough the -592C/A polymorphism was not associated with type 2 diabetes, nondiabetic homozygous carriers of the A allele showed increased BMI and insulin resistance and lower plasma IL-10 levels compared with the other genotypes.16644716
ObesityDeregulated Nutrient SensingThe ATA/ATA composite genotype was associated with an increased risk for obesity (1.96 [1.16-3.31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01).16644716
ObesityDeregulated Nutrient SensingThis study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians.16644716
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigh circulating IL-6 levels have been associated with insulin resistance and greater risk of type 2 diabetes.16644865
Cholestatic liver disease, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe recognition of dyslipidemia and atherosclerosis in those with cholestatic liver disease and the normalization of lipid profile after liver transplantation warrant further study.16645435
Hypertensive (finding), Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCardiovascular risk factors as Body Mass Index (BMI), diabetes, a family history of dyslipidemia and diabetes were more frequent among prehypertensive and hypertensive individuals, than in normotensive ones.16649511
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPatients had an overall prevalence of smoking, obesity, hypertension, dyslipidemia, and diabetes mellitus about twice that of the reference group.16649830
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingAlthough previous studies have shown that African subjects have a lower visceral adipose depot size than European subjects, abdominal obesity is still associated with insulin resistance and dyslipidaemia.16649973
Primary malignant neoplasm, Neoplasms, Eccrine acrospiromaDeregulated Nutrient SensingClear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer.16670462
Arterial Stiffness, Antihypertensive AgentsDeregulated Nutrient SensingInsulin resistance is associated with arterial stiffness in nondiabetic hypertensives independent of metabolic status.16671332
Arterial Stiffness, Hypertensive (finding)Deregulated Nutrient SensingWe sought to determine whether insulin resistance (IR) is related to arterial stiffness in nondiabetic hypertensive patients, independent of metabolic status and gender.16671332
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBeta cell function, insulin resistance and plasma adiponectin concentrations are predictors for the change of postprandial glucose in non-diabetic subjects at risk for type 2 diabetes.16673209
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance, impaired insulin secretion, and low adiponectin levels have been shown to be predictors for type 2 diabetes.16673209
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingApproximately 15-40% of the patients had obtained the treatment goals for hypertension, dyslipidemia and type 2 diabetes.16674875
Arterial StiffnessDeregulated Nutrient SensingEffect of postprandial insulinemia and insulin resistance on measurement of arterial stiffness (augmentation index).16675046
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia and elevated blood pressure are associated significantly already with modest rises in waist girth adjusted for age and smoking.16678831
Overweight, ObesityDeregulated Nutrient SensingAs the prevalence of overweight and obesity increases, the risk of insulin resistance rises.16679218
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingAssociation of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus.16681424
Proteinuria, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn the New-DM patients, 41.8% were accompanied with hypertension, 43.2% with proteinuria, and 67.6% with dyslipidemia.16681969
Proteinuria, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingProteinuria, dyslipidemia, and hypertension were the concomitant disorders frequently found in New-DM.16681969
Beta-cell dysfunction, Diabetes MellitusDeregulated Nutrient SensingBoth insulin resistance and beta-cell dysfunction are implicated in this patients' diabetes pathophysiology.16684489
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOverweight or obesity, dyslipidemia and insulin resistance were risk factors of hypertension in Mongolian people.16685579
DyslipidemiasDeregulated Nutrient SensingAmong 4,885 patients receiving treatment for dyslipidemia, 79.7% were non-Hispanic white (NHW) and 8.4% were AA.16686806
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.16691186
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType II diabetes is caused by a failure of the pancreatic beta-cells to compensate for insulin resistance leading to hyperglycaemia.16691186
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFASL and FAS map to loci linked to type II diabetes and estimates of insulin resistance, respectively.16691186
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects.16691186
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis drug, because of its decreasing effect on insulin resistance, is used alone or combined with type 2 diabetic drugs.16698744
DyslipidemiasDeregulated Nutrient SensingStatins, drugs used to treat dyslipidemia, may have anticancer properties.16702371
Glucose Intolerance (disease), Hyperparathyroidism, PrimaryDeregulated Nutrient SensingPrevalence of glucose intolerance in primary hyperparathyroidism and the benefit of parathyroidectomy.16703622
Demographics Domain, Glucose Intolerance (disease), Hyperparathyroidism, Primary, Diabetes MellitusDeregulated Nutrient SensingIncreased prevalence of diabetes mellitus (DM) in primary hyperparathyroidism (PHPT) is established, but not glucose intolerance (GI), nor benefit from parathyroidectomy on GI.16703622
Coronary Artery Disease, Dyslipidemias, Heart failure, Diabetes MellitusDeregulated Nutrient SensingPatients who died were older, more frequently had a history of diabetes or coronary artery disease, were more likely to have heart failure at admission, had higher troponin-I, myoglobin and creatinine levels, and were less likely to have dyslipidemia or to be a smoker.16712744
Inflammation, Cardiovascular DiseasesDeregulated Nutrient SensingPlasma leptin is associated with insulin resistance, inflammation and disturbances in haemostasis independent of waist circumference, suggesting possible pathways by which leptin may influence risk of cardiovascular disease.16712853
Obesity, AbdominalDeregulated Nutrient SensingThe prevalence of insulin resistance, general and abdominal obesity, low HDL-C and physical inactivity was higher in women than men in the 2 age groups.16714005
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type 2 diabetes mellitus.16714840
Diabetes MellitusDeregulated Nutrient SensingIn this study, we investigated the association between the serum CRP concentrations and parameters of adiposity and insulin resistance in both Japanese type 2 diabetes patients and non-diabetic subjects.16714840
Metabolic Syndrome XDeregulated Nutrient SensingAn increase in the number of risk factors for metabolic syndrome was highly correlated with an increased baPWV, probably due to insulin resistance.16715651
Increased insulin level, "Alzheimers Disease", Data types - Address, Memory impairmentDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are risk factors for memory impairment and Alzheimer disease (AD).16717209
Malabsorption Syndrome, diabeticDeregulated Nutrient SensingTo investigate non-invasively the incidence of absorption of carbohydrates in diabetic patients during an oral glucose tolerance test (OGTT) and to determine whether malabsorption may be associated with insulin secretion and insulin resistance.16718794
Malabsorption SyndromeDeregulated Nutrient SensingInsulin resistance may be overestimated by using these markers if the patient has carbohydrate malabsorption, or that carbohydrate malabsorption may be present prior to the development of insulin resistance.16718794
Malabsorption SyndromeDeregulated Nutrient SensingHence carbohydrate malabsorption should be taken into account for estimating insulin resistance and beta-cell function.16718794
ObesityDeregulated Nutrient SensingIn AS, severe childhood obesity, waist circumference, and body fat decrease with age, whereas insulin resistance increases.16720663
Obesity, AbdominalDeregulated Nutrient SensingAging is associated with insulin resistance, primarily as a result of physical inactivity and increased abdominal obesity.16720745
Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTestosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.16728551
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe investigated the effect of testosterone treatment on insulin resistance and glycaemic control in hypogonadal men with type 2 diabetes.16728551
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTestosterone replacement therapy reduces insulin resistance and improves glycaemic control in hypogonadal men with type 2 diabetes.16728551
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingLow levels of testosterone in men have been shown to be associated with type 2 diabetes, visceral adiposity, dyslipidaemia and metabolic syndrome.16728551
Heart Diseases, Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Cerebrovascular accidentDeregulated Nutrient SensingCoexistence of insulin resistance and inflammation effectively predicts cardiac disease but not stroke in Japanese patients with type 2 diabetes mellitus.16730841
Inflammation, macroangiopathyDeregulated Nutrient SensingIt is well known that insulin resistance (IR) and inflammation (IF) are associated with macroangiopathy.16730841
Toxic effectDeregulated Nutrient SensingPeroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.16731822
Diabetes MellitusDeregulated Nutrient SensingEpidemiological studies suggest that high body iron stores are associated with insulin resistance and type 2 diabetes.16732023
Hyperglycemia, Cardiac complication, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHyperglycaemia in Type 2 diabetes has a major role in the development of microvascular complications, whereas the dyslipidaemia is the major cause of macrovascular complications.16732709
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn patients with Type 2 diabetes, activation of PPAR-alpha and PPAR-gamma with the fibrates and glitazones improves dyslipidaemia and increases insulin sensitivity, respectively.16732709
Increased insulin levelDeregulated Nutrient SensingObese children exhibited hyperinsulinemia and insulin resistance; however, trans fatty acid intake or their plasma levels were not associated with them.16733524
Blood GlucoseDeregulated Nutrient SensingOverall, tight glycemic regulation is achieved in a broad critical care cohort with optimized insulin and nutrition delivery, effectively managing glycemia even with high effective insulin resistance.16734548
ThalassemiaDeregulated Nutrient SensingInsulin resistance and beta cell function in chronically transfused patients of thalassemia major.16735760
Increased insulin level, Splenomegaly, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance, compensated by hyperinsulinemia, sets in early even before the onset of frank diabetes mellitus and correlated well with age, chelation therapy and indicators of iron overload like total units of blood transfused, splenomegaly and serum ferritin.16735760
Multiparity, Glucose Intolerance (disease)Deregulated Nutrient SensingGlyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multiparity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group.16738156
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAdherence with follow-up, physician recommendations, and new diagnoses of diabetes, hypertension, and dyslipidemia.16739759
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingHypertension was the most commonly encountered risk factor followed by dyslipidemia, diabetes mellitus, and obesity.16740438
Dyslipidemias, diabeticDeregulated Nutrient SensingThe effects of different doses of atorvastatin on plasma endothelin-1 levels in type 2 diabetic patients with dyslipidemia.16741040
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTwenty-nine type 2 diabetic patients with dyslipidemia were enrolled and randomly assigned to receive atorvastatin orally at 10 mg (A10; n = 10), 20 mg (A20; n = 10), or 40 mg (A40; n = 9) daily for 12 weeks.16741040
Dyslipidemias, diabeticDeregulated Nutrient SensingThe clinical significance of these biphasic lipid-independent statin effects is unknown and the present study suggests that 20 mg atorvastatin may have the best benefits in treating diabetic patients with dyslipidemia.16741040
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCardiovascular disease had been diagnosed previously in 0.7% of workers, hypertension in 6.2%, diabetes in 1.2%, and dyslipidemia in 8.9%.16750139
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingRetrospective review of sex differences in the management of dyslipidemia in coronary heart disease: an analysis of patient data from a Maryland-based health maintenance organization.16750470
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingStatins effectively treat dyslipidemia and reduce the risk of CHD mortality.16750470
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe objective of this study was to evaluate the treatment of dyslipidemia in patients with CHD and determine if sex differences exist.16750470
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingA significant gap in dyslipidemia treatment in these CHD patients remained, particularly for women.16750470
Alzheimers DiseaseDeregulated Nutrient SensingNeuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.16751189
Alzheimers DiseaseDeregulated Nutrient SensingIn this study we report for the first time that promotion of the NAD+-dependent sirtuin, SIRT1-mediated deacetylase activity, may be a mechanism by which CR influences Alzheimer disease (AD)-type amyloid neuropathology.16751189
Amyloid NeuropathiesDeregulated Nutrient SensingThese results demonstrate for the first time a role for SIRT1 activation in the brain as a novel mechanism through which CR may influence AD amyloid neuropathology.16751189
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Kidney DiseasesDeregulated Nutrient SensingType 2 diabetes mellitus in young people was associated with early onset nephropathy and dyslipidaemia (almost from diagnosis), thus suggesting the need for earlier diagnosis.16751833
Immature, DyslipidemiasDeregulated Nutrient SensingThe presence of dyslipidemia was more prevalent among offspring adolescents of premature CAD patients, but it was responsive to nutritional intervention.16751940
AtherosclerosisDeregulated Nutrient SensingWe previously showed that 3'-end haplotypes in the LPL gene influence atherosclerosis and insulin resistance.16755277
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIt should be implemented in cases that are aged over 40 with at least one additional risk such as hypertension, obesity, dyslipidemia.16756047
Acute myocardial infarctionDeregulated Nutrient SensingInsulin resistance in nondiabetic patients with acute myocardial infarction.16757401
RestenosisDeregulated Nutrient SensingRecent studies have shown that insulin resistance (IR) is an independent predictor of early restenosis after coronary stenting.16757401
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine how these multiple roles may relate to insulin resistance, we studied the regulation of GSK-3 protein expression and phosphorylation in skeletal muscle and isolated adipocytes from nonobese healthy control (HC), obese control (OC), and obese type 2 diabetic (OT2D) subjects.16757548
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffect of chromium on the insulin resistance in patients with type II diabetes mellitus.16761396
Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingThe aim of the present study was to evaluate the effect of chromium on the insulin resistance in diabetic patients with type II diabetes mellitus.16761396
Diabetes MellitusDeregulated Nutrient SensingChromium included early in the complex therapy of diabetes is beneficial in the reduction of the degree of insulin resistance.16761396
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingDyslipidemia has become a common problem in HIV disease, especially in patients on combination antiretroviral (ARV) therapy.16770290
Pain Distress Question, Small Fiber Neuropathy, Diabetes MellitusDeregulated Nutrient SensingSomatic cutaneous small sensory fiber neuropathy (SSFN) can be an early manifestation of impaired glucose tolerance and diabetes mellitus and/or insulin resistance among obese subjects and is often associated with pain, wound occurrence and impaired wound healing.16770330
Chronic liver diseaseDeregulated Nutrient SensingResistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases.16771945
Increased insulin level, Liver CirrhosisDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are present in nearly all patients with liver cirrhosis.16771945
Liver DysfunctionDeregulated Nutrient SensingElevated resistin may contribute to insulin resistance in advanced liver dysfunction.16771945
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingUse of U-500 regular insulin by continuous subcutaneous insulin infusion in patients with type 2 diabetes and severe insulin resistance.16772195
Diabetes Mellitus, Non-Insulin-Dependent, Failure (biologic function)Deregulated Nutrient SensingTo determine the safety and efficacy of U-500 regular insulin delivered by continuous subcutaneous insulin infusion (CSII) as treatment for patients with type 2 diabetes and severe insulin resistance (mean 24-hour insulin requirement, 1.46 U/kg daily) who had failure of previous insulin therapy with either multiple daily injection (MDI) regimens or CSII using U-100 insulin analogues.16772195
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe study group consisted of 9 patients with type 2 diabetes and severe insulin resistance with hemoglobin A1c (A1C) values that exceeded 7.0%.16772195
Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingEndogenous hyperinsulinemia, along with insulin resistance, is associated with hypertension.16772245
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingOther underlying risk factors were diabetes mellitus, smoking, cardiovascular disease and dyslipidemia.16773973
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, in view of the strong association between type 2 diabetes and UA stone formation, it is proposed that UA nephrolithiasis may be added to the conditions that potentially are associated with insulin resistance.16775030
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpaired insulin secretion (IS) and insulin resistance (IR) play an essential role in the pathogenesis of type 2 diabetes mellitus.16776626
Hyperglycemia, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalences of insulin resistance, dyslipidemia, hypertension and hyperglycemia were higher among higher WC categories for both men and women.16780737
Tumor necrosis, Obesity, Diabetes MellitusDeregulated Nutrient SensingTumour necrosis factor (TNF)alpha is implicated in the relationship between obesity and insulin resistance/ type 2 diabetes.16784178
HypercholesterolemiaDeregulated Nutrient SensingInsulin resistance, adipokines, and oxidative stress in nondiabetic, hypercholesterolemic patients: leptin as an 8-epi-prostaglandin F2alpha determinant.16784964
SchizophreniaDeregulated Nutrient SensingInsulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report.16786820
Schizophrenia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBy direct measurement, this study provides evidence of insulin resistance and susceptibility to type 2 diabetes in patients with schizophrenia who are free of antipsychotic drugs.16786820
ObesityDeregulated Nutrient SensingACS1 expression was negatively correlated with measures of insulin resistance and central obesity (ACS1 versus HOMA: r = -0.28, P<0.05; ACS1 versus WHR: r = -0.23, P<0.05), with an opposite trend for FATP4.16788709
Angina Pectoris, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Hypertensive (finding)Deregulated Nutrient SensingOut of 8780 ABPM recordings we identified 79 hypertensive patients (both genders) who suffered a first nonfatal ischemic event, either cerebrovascular (stroke or transient ischemic attack) (STR/TIA, n = 48) or coronary (myocardial infarction, angina or coronary bypass/PTCA) (COR, n = 31) and 223 control-hypertensive patients (CTR) without any events during the same period who were fully matched (at the time of ABPM) for age, gender, antihypertensive therapy, presence of dyslipidemia or diabetes, and casual blood pressure (BP), in the proportion of 1 STR/TIA to 3 CTR and 1 COR to 6 CTR.16789404
Chronic heart failure, Cachexia, Congestive heart failureDeregulated Nutrient SensingIt is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism.16789974
DyslipidemiasDeregulated Nutrient SensingSustained improvement of dyslipidaemia in HAART-treated patients replacing stavudine with tenofovir.16791015
DyslipidemiasDeregulated Nutrient SensingThe substitution of tenofovir for stavudine causes a sustained improvement of dyslipidaemia.16791015
Acromegaly, Cardiomyopathies, Cardiac complication, Glucose Intolerance (disease), Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingIncreased morbidity and mortality with acromegaly is associated with cardiovascular complications, hypertension, glucose intolerance, cardiomyopathy and coronary artery disease.16793566
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient Sensing[Association of serum leptin and insulin resistance with nonalcoholic fatty liver disease].16793619
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingIncreased leptin level, HOMA-IR, BMI and dyslipidemia can be important risk factors of NAFLD, and serum leptin level and HOMA-IR are positively correlated with the severity of NAFLD.16793619
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Hyperparathyroidism, PrimaryDeregulated Nutrient SensingDyslipidemia, hypertension, diabetes mellitus and also primary hyperparathyroidism (pHPT) are associated with an increased risk of cardiovascular diseases.16793947
AcromegalyDeregulated Nutrient SensingEffects of the long-acting somatostatin analogue Lanreotide Autogel on glucose tolerance and insulin resistance in acromegaly.16793952
Dyslipidemias, diabeticDeregulated Nutrient SensingAlmost the half (41 %) was diabetic, and 27 % had dyslipidemia.16796409
Dyslipidemias, diabeticDeregulated Nutrient SensingWe hypothesized that the combination of TZD+fibrate may be better than the sulfonylurea + statin approach regarding modifying the adipokine profile in diabetic patients with dyslipidemia.16799399
Dyslipidemias, Obesity, diabeticDeregulated Nutrient SensingIn a survey of 98 consecutive admissions of diabetic patients, <40% had a MS; this is a low value compared to younger diabetic adults, due to a low prevalence of obesity and dyslipidemia.16799400
OverweightDeregulated Nutrient SensingSurrogate indexes vs. euglycaemic-hyperinsulinemic clamp as an indicator of insulin resistance and cardiovascular risk factors in overweight and obese postmenopausal women.16799402
OverweightDeregulated Nutrient SensingSurrogate measures of insulin resistance, in particular fasting insulin, are simple tools appropriate for epidemiological studies that can be used as substitutes for the EH clamp to estimate glucose disposal and cardiovascular risk factors in overweight and obese postmenopausal women.16799402
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingVisceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease.16799888
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver diseases are often associated with obesity, insulin resistance, and excessive visceral fat accumulation.16799888
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe severity of fatty liver was positively correlated with visceral fat accumulation and insulin resistance in both obese and nonobese subjects, suggesting that hepatic fat infiltration in nonalcoholic fatty liver disease may be influenced by visceral fat accumulation regardless of body mass index.16799888
Hypogonadism, HypothyroidismDeregulated Nutrient SensingThe prevalence of hypothyroidism in splenectomized patients was significantly higher (P = 0.005), whereas the presence of hypogonadism, impaired glucose homeostasis and insulin resistance, although more frequent, was not statistically significant.16800840
Fatty Liver, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingTo investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in a group of obese children (BMI > 97th %) and to establish correlations between the severity of hepatic fatty infiltration, auxological findings and parameters of insulin resistance.16801180
Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingAlthough studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse.16801582
Diabetes MellitusDeregulated Nutrient SensingUse of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).16801588
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingShort stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.16801590
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur study supports the hypothesis that adult markers of prepubertal growth, especially leg length-to-height ratio, are associated with adiposity, insulin resistance, and type 2 diabetes in the general U.S. population.16801590
DyslipidemiasDeregulated Nutrient SensingIn patients on hemodialysis, dyslipidemia is generally characterized by increased concentrations of LDL cholesterol and triglycerides, and a decreased concentration of HDL cholesterol, as also confirmed by our study.16802568
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingRecently it was reported that adipokines are closely associated with the common risk factors for NAFLD, such as obesity, diabetes, dyslipidemia, and insulin resistance.16804347
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe risk factors found were Hypertension in 37 (80.4%) of patients, diabetes in 16 (34.8%), and Dyslipidaemia in 20 (43.5%).16805167
Hypoadiponectinemia, AtherosclerosisDeregulated Nutrient SensingPresent and further clinical relevant to atherosclerosis in this patient should be imformative concerning the pathogenesis and treatment of atherosclerosis in the presence of hypoadiponectinemia and insulin resistance.16806559
Breast CarcinomaDeregulated Nutrient SensingInsulin resistance, growth factors and cytokine levels in overweight women with breast cancer before and after chemotherapy.16807226
Breast CarcinomaDeregulated Nutrient SensingTo evaluate insulin values, insulin resistance, growth factors and cytokine levels in women suffering from breast cancer and the effect of chemotherapy on these parameters.16807226
Apolipoprotein E, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPolymorphism of the apolipoprotein E (APOE) gene has been associated with dyslipidemia and cardiovascular disease.16815257
Dyslipidemias, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingCardiovascular diseases are more common in renal transplant recipients than in the general population, and a number of 'traditional' risk factors, such as smoking, diabetes mellitus and dyslipidaemia, are known to be associated with an increased risk.16815854
Diabetes MellitusDeregulated Nutrient SensingIncreasingly strong links are being recognized between diabetes, insulin resistance and liver fat accumulation [e.g.16817817
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe results suggest that glucosamine ingestion may affect glucose levels and consequent glucose uptake in patients who have untreated diabetes or glucose intolerance.16818461
Obesity, VisceralDeregulated Nutrient Sensing[The relationship between testosterone and dehydroepiandrosterone sulfate concentrations, insulin resistance and visceral obesity in elderly men].16821208
Increased insulin level, Hypercholesterolemia, metabolic disturbanceDeregulated Nutrient SensingIn these men also changes of body composition (visceral obesity, increasing of fat mass), and metabolic disturbances (hypercholesterolemia, hyperinsulinism and insulin resistance) are common disorders.16821208
Testosterone Deficiency, CTCAE, Obesity, VisceralDeregulated Nutrient SensingVisceral obesity and insulin resistance may be either reasons or effects of testosterone deficiency.16821208
Testosterone Deficiency, CTCAE, Obesity, VisceralDeregulated Nutrient SensingProbably also DHEA-S deficiency is the risk factor of visceral obesity and insulin resistance, but it is not clear, whether this possible influence is independent from testosterone deficiency.16821208
ObesityDeregulated Nutrient SensingDHEA-S and testosterone deficiency were independently associated with higher insulin resistance and obesity.16821208
Coronary heart diseaseDeregulated Nutrient Sensing[Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease--preliminary study].16821209
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe aim of this study was to analyze the influence of DHEA therapy on insulin resistance (FIRI, FG/FI) and serum lipids in men with angiographically verified coronary heart disease (CHD).16821209
Dyslipidemias, Hypertension, CTCAE, Hyperuricemia, ObesityDeregulated Nutrient SensingObesity, hypertension, and dyslipidemia are the major factors associated with hyperuricemia in this study.16821269
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingPhysicians should be aware of the possibility of dyslipidemia, particularly hypertriglyceridemia, following treatment with capecitabine.16821596
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTargeting insulin resistance in type 2 diabetes patients suboptimally controlled with insulin.16822926
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingMultiple cardiovascular risks (dyslipidemia, hypertension, and diabetes) are addressed.16823999
Complications of Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes.16824933
Increased insulin level, Overweight, Pre-EclampsiaDeregulated Nutrient SensingIt is controversial whether insulin resistance (IR) is present in preeclamptic patients, and it is unclear if hyperinsulinemia is dependent upon being overweight during pregnancy or on preeclampsia per se.16824935
Hyperlipidemia, Thrombosis, Inflammation, Hyperglycemia, Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingUnexpectedly, evidence was developed that four major attributes of sympathetic activation represent four major risk factors; attributes of sympathetic activation are a tendency toward thrombosis and vasoconstriction, lipidemia, inflammation, and hyperglycemia, and corresponding risk factors are endothelial dysfunction (which expresses thrombosis/vasoconstriction and epitomizes this tendency), dyslipidemia, inflammation, and insulin resistance.16828234
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingThese findings, plus other information, provide evidence that dyslipidemia acts mainly as a marker of risk of IHD, rather than being the basic mechanism of this disorder.16828234
Thrombosis, Atherosclerosis, Dyslipidemias, Infarction, atheroscleroticDeregulated Nutrient SensingIt seems generally accepted that dyslipidemia results rather automatically in infarction through the sequence of atherosclerosis, atherosclerotic complications, and thrombosis.16828234
Metabolic Diseases, Somatotropin deficiencyDeregulated Nutrient SensingInsulin resistance may play a role in glucose and lipid metabolism disorders associated with GHD.16829702
AlopeciaDeregulated Nutrient SensingAssociation of insulin resistance linked diseases and hair loss in elderly men.16830609
Androgenetic Alopecia, Myocardial IschemiaDeregulated Nutrient SensingPrevious investigations have shown an association of androgenetic alopecia (AGA) with insulin resistance related disorders such as ischemic heart disease.16830609
Blood GlucoseDeregulated Nutrient SensingAdditionally, other measures of glycemia and insulin resistance also dose-dependently increased with increasing fasting and post-load glucose levels (p<0.001 for all).16840831
Angina Pectoris, Cardiovascular Diseases, Blood Glucose, Coronary heart disease, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance is clearly associated with increasing risk of cardiovascular disease, but the association among increasing glycemia and cardiovascular risk factors, angina and coronary heart disease in normoglycemic subjects is less clear, particularly in Chinese.16840831
Organ Dysfunction ScoresDeregulated Nutrient SensingA growing body of animal and human data has correlated insulin resistance with organ dysfunction.16843864
Biliary calculi, GallbladderDeregulated Nutrient SensingThese data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance.16843864
Gallbladder, Biliary calculi, Acalculous CholecystitisDeregulated Nutrient SensingWe conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation.16843864
Peripheral Vascular Diseases, Dyslipidemias, Diabetes Mellitus, Congestive heart failureDeregulated Nutrient SensingThe frequency of diabetes, congestive heart failure, peripheral vascular disease, and dyslipidemia were common, but not different between groups.16844637
Bipolar Disorder, HostilityDeregulated Nutrient SensingThe severity of depressive symptoms, hostility, and anger expression was positively associated with estimated insulin resistance (IR) and insulin in women but not in men.16846323
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and declining beta-cell function are the core defects in type 2 diabetes mellitus.16846554
Diabetic NephropathyDeregulated Nutrient SensingThe correlation of insulin resistance and renal function in non diabetic chronic kidney disease patients.16858947
Injury of kidneyDeregulated Nutrient SensingA greater degree of insulin resistance may predispose to renal injury by worsening renal hemodynamics through the elevation of glomerular filtration fraction.16858947
Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingHowever, there are sparse data on the relationship between insulin resistance, glomerular filtration rate (GFR) and body composition in chronic kidney disease (CKD) without diabetes.16858947
Chronic Kidney DiseasesDeregulated Nutrient SensingIn non-diabetic CKD patients, the independent factor for insulin resistance was the amount of total body fat.16858947
LipodystrophyDeregulated Nutrient SensingLipodystrophy, an altered development and/or repartition of body fat, is associated with alterations of lipid and glucose metabolism with insulin resistance.16860281
diabeticDeregulated Nutrient Sensing[The influence hypocaloric diet in insulin resistance, functional active beta-cell and metabolism lipids in type 2 diabetic patients].16862952
diabeticDeregulated Nutrient SensingIt was investigated the influence of traditional hypocaloric diet on dynamic of glucaemia, insulin resistance, beta-cell function, lipid peroxidation, level of hormone resistin and enzymes of antioxidant system in type 2 diabetic patients.16862952
diabeticDeregulated Nutrient SensingOur results show that diet therapy improves metabolic control in type 2 diabetic patients, and as a result of a diet were normoglucaemia, decrease of insulin resistance, lipid peroxidation, but also decrease of enzymes of antioxidant system and moderate decrease of beta-cell function.16862952
Overweight, ObesityDeregulated Nutrient SensingHowever, by multiple logistic regression, female gender, overweight and obesity, and elevated WBC count were all found to be independent risk factors of insulin resistance, but age, RBC and platelet counts were not.16863009
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingStudies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.16865358
Obesity, Diabetes MellitusDeregulated Nutrient SensingThis polymorphism has been studied in relation to insulin resistance, type 2 diabetes and obesity in several populations with conflicting results.16865358
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNo significant associations with type 2 diabetes or related quantitative metabolic traits, including measures of insulin resistance, were detected.16865358
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity is associated with insulin-resistance (IR), type 2 diabetes (T2D) and a constellation of cardiovascular risk factors at the early years of life.16868146
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.16868148
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe ACAA-insertion/deletion polymorphism at the 3' UTR of IGFIIR is associated with type 2 diabetes and influences surrogate markers of insulin resistance in non-diabetic subjects.16868148
DyslipidemiasDeregulated Nutrient SensingThese results suggest that whereas chronic dyslipidemia associated with elevated triglycerides may reduce auditory function, short-term dietary changes may not.16868509
Hepatobiliary Disorder, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingA simple lifestyle advice program significantly improves insulin resistance, and the liver disease in pediatric NAFLD.16871574
Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Heart Diseases, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of complications was estimated using the 2nd assumption, as was the prevalence of hypertension, dyslipidemia, Ischemic Heart Disease (IHD) and stroke in the non-diabetic population in 2014.16871830
Data types - Address, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingWe extended this line of research by attempting to correlate the deficits in insulin/IGF signaling and energy production with mitochondrial dysfunction, oxidative injury, and compensatory cyto-protective responses in brains with different Braak Stage severities of AD.16873964
Hypertensive (finding), ObesityDeregulated Nutrient SensingIn untreated individuals, a significant interaction was observed between obesity and insulin resistance as related to FPRNa (P = 0.002): the highest age-adjusted levels of FPRNa were detected in obese hypertensive and obese insulin-resistant participants.16877967
Asthma, Dyslipidemias, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThe most common co-morbidity was diabetes mellitus, found in 98 (38.4%), followed by dyslipidemia in 50 (19.6%), bronchial asthma in 28 (11.0%) and renal diseases in 12 (4.7%).16883084
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingGH peak response to GHRH-arginine and cardiovascular risk factors, including obesity, insulin resistance, low levels of high density lipoprotein (HDL) cholesterol, elevated triglycerides, and hypertension.16886956
DyslipidemiasDeregulated Nutrient SensingContemporary management of dyslipidemia in high-risk patients: targets still not met.16887414
Metabolic Syndrome XDeregulated Nutrient SensingCutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults.16891815
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingThus, in general, it augments glucose intolerance in diabetic patients.16891829
Persian language, ObesityDeregulated Nutrient SensingThe lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment.16894240
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingCranial irradiation was strongly related to GH deficiency, and in turn lower insulin-like growth factor 1 (IGF-1), higher fasting insulin, abdominal obesity, and dyslipidemia, particularly in women.16894525
HypogonadismDeregulated Nutrient Sensing[Hypogonadism may cause insulin resistance in young males].16894938
HypogonadismDeregulated Nutrient Sensing(2) HOMA-IR and fast insulin levels were significantly higher in the hypogonadism group than in the control, which suggests that lower serum testosterone may cause insulin resistance in young male patients.16894938
Hyperglycemia, Critical Illness, Diabetes MellitusDeregulated Nutrient SensingHyperglycemia and insulin resistance frequently occur in critically ill patients even without a history of diabetes.16895955
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingAlthough the VPSO group resembled the PCOS group in their 17PROG response to the GnRHag test, they differed in having significantly smaller ovaries and lower body mass index and in lacking evidence of peripheral androgen excess and of insulin resistance.16895960
Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingDiabetes of short duration with insulin use conferred a substantially elevated risk for pancreatic cancer and may reflect insulin resistance that is elicited by pancreatic cancer.16896032
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingEfficacy and safety of coadministered amlodipine and atorvastatin in patients with hypertension and dyslipidemia: results of the AVALON trial.16896273
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingConcomitant administration of amlodipine and atorvastatin is an effective and well tolerated treatment for coexisting hypertension and dyslipidemia.16896273
Dyslipidemias, Retinal Diseases, Diabetes MellitusDeregulated Nutrient SensingAn accumulation of certain genotypes of candidate genes for diabetes mellitus type 2 is associated with the severity of dyslipidemia and microvascular late complications, e.g., grade of retinopathy.16896567
Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingInsulin resistance differed substantially between lean (BMI < 25 kg/m2), overweight or obese (BMI > or = 25 kg/m2), and type 2 diabetic individuals.16899806
Overweight, ObesityDeregulated Nutrient SensingIn conclusion, a superior fasting-based index estimate to distinguish between the presence and absence of insulin resistance in overweight and obesity could not be identified despite the use of the large datasets.16899806
Cardiovascular DiseasesDeregulated Nutrient SensingMenopause, insulin resistance, and risk factors for cardiovascular disease.16900080
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingFamilial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease.16901766
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAn association between nonalcoholic fatty liver disease (NAFLD) and the insulin resistance (IR) syndrome exists.16901766
HIV Infections, Diabetes MellitusDeregulated Nutrient SensingTo determine factors associated with diabetes, insulin resistance, and abnormal glucose tolerance in older men with or at risk of HIV infection.16903984
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDirect association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance.16911630
diabeticDeregulated Nutrient SensingIn addition, within the group of diabetic patients, the TT genotype was commoner in subjects with increased homeostasis model assessment (HOMA) index for insulin resistance.16911630
diabeticDeregulated Nutrient SensingMoreover, within the diabetic subjects, this CD36 snp was associated with insulin resistance (HOMA index).16911630
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study.16913878
Hypertension, CTCAEDeregulated Nutrient SensingWe explored the relations of leukocyte telomere length, expressed by terminal restriction fragment (TRF) length, with insulin resistance, oxidative stress and hypertension.16913878
Hypertension, CTCAE, Antihypertensive AgentsDeregulated Nutrient SensingCollectively, these observations suggest that hypertension, increased insulin resistance and oxidative stress are associated with shorter leukocyte telomere length and that shorter leukocyte telomere length in hypertensives is largely due to insulin resistance.16913878
Heart failureDeregulated Nutrient SensingThe aim of this study was to investigate the hemodynamic response to the beta-adrenergic agonist isoproterenol and to identify molecular deficiencies that may be predictive of cardiac failure in a low-birth weight rodent model that develops insulin resistance and type 2 diabetes in adulthood.16914429
Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Obesity, Erectile dysfunction, Hypertension, CTCAE, atheroscleroticDeregulated Nutrient SensingErectile dysfunction (ED) is associated with clinical atherosclerosis and several atherosclerotic risk factors including smoking, hypertension, dyslipidemia, diabetes mellitus, obesity and sedentary lifestyle.16915303
Inflammation, Thrombosis, DyslipidemiasDeregulated Nutrient SensingWe conclude that selected biomarkers for endothelial function, thrombosis and dyslipidemia but not inflammation are associated with the degree of ED in this cross-sectional analysis.16915303
Thrombus, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and thrombotic processes are both clearly involved in atherogenesis and its secondary complications.16916537
Apolipoproteins BDeregulated Nutrient SensingMoreover, increasing CRP concentration in this paediatric population was associated with an enhanced CV risk profile, consisting of increased adiposity, higher insulin resistance, worsening lipid profile (higher total cholesterol, triglycerides, low-density lipoprotein cholesterol, apolipoprotein B and total cholesterol : high-density-lipoprotein cholesterol ratio), increased leptin and decreased adiponectin.16918582
HyperglycemiaDeregulated Nutrient SensingIn conclusion, the present study suggested that the A/L ratio might be more useful than HOMA-R to accurately assess insulin resistance in subjects without hyperglycemia.16919546
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingInadequate treatment of dyslipidemia in people with type 2 diabetes: quality assessment of diabetes care in a Danish County.16923628
NAD-Dependent Deacetylase Sirtuin-3, MitochondrialDeregulated Nutrient SensingHuman SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1.16923962
Prostate carcinomaDeregulated Nutrient SensingDHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins.16923962
Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingWhile hs-CRP associates with insulin resistance and subclinical atherosclerosis in ealy-state type 2 diabetes, our data suggest that hs-CRP is a useful marker of subclinical atherosclerosis in early-state type 2 diabetes mellitus independent of factors that directly reflect insulin resistance.16926521
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPolymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.16936218
Colorectal Carcinoma, Structure of beta Cell of islet, Hyperinsulinism, Diabetes MellitusDeregulated Nutrient SensingThe neoplastic process in the colon is not associated with hyperinsulinaemia or insulin resistance, but in CRC patients, pancreatic B-cell dysfunction typical of the early stages of diabetes is seen.16938722
AtherosclerosisDeregulated Nutrient SensingThis was a population-based, prospective cohort study (the Atherosclerosis and Insulin Resistance study) conducted in Goteborg, Sweden, among 313 Caucasian men without cardiovascular or other clinically overt diseases.16940451
Communicable Diseases, DyslipidemiasDeregulated Nutrient SensingPeriodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression.16941280
ObesityDeregulated Nutrient SensingHowever, more recent data suggest that low androgen levels are associated with adverse cardiovascular risk factors, including an atherogenic lipid profile, obesity and insulin resistance.16943795
Dyslipidemias, Diabetes Mellitus, Thyroid Diseases, Nephrotic Syndrome, Obesity, Kidney FailureDeregulated Nutrient SensingThe exclusion criteria were renal failure, nephrotic syndrome, thyroid or liver disease, diabetes mellitus, obesity, pregnancy and taking drugs that induce dyslipidemia.16944155
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSince dyslipidemia is common in diabetes and is associated with increased cardiovascular risk, we tested the hypothesis that Thr-54 is associated with increased cardiovascular risk in patients with diabetes.16945373
Inflammation, RestenosisDeregulated Nutrient SensingInsulin resistance or inflammation is known to be related with lipoprotein lipase activity and these factors are also closely associated with the pathogenesis of bare-metal stent restenosis.16948449
DyslipidemiasDeregulated Nutrient SensingThese modifications are independent of the degree of dyslipidemia and may represent an indicator of reduced cardiovascular risk.16948972
Glucose Intolerance (disease), Hepatocellular AdenomaDeregulated Nutrient SensingHepatic adenomatosis in a young woman with glucose intolerance.16951669
Alcoholic Intoxication, Chronic, Dyslipidemias, Sedentary, Smoking, Diabetes Mellitus, Coronary heart disease, Hypertension, CTCAEDeregulated Nutrient SensingPersonal antecedents for coronary disease (smoking, dyslipidemia, diabetes mellitus, arterial hypertension, family antecedents, sedentarism, and alcoholism) were analyzed.16951828
HypoadiponectinemiaDeregulated Nutrient SensingInsulin resistance and hypoadiponectinemia were found in these MS children.16953257
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThis case report suggests that the incretin mimetic exenatide decreases hepatic fat accumulation and may play a role in the future treatment of NAFLD, and the associated insulin resistance and cardiovascular risk factors in an ever-growing high-risk population.16953843
Glucose Intolerance (disease)Deregulated Nutrient SensingWe concluded that isoprostanes may not be causally involved in the development of glucose intolerance, insulin resistance or deteriorating BCF.16956690
Glucose Intolerance (disease)Deregulated Nutrient SensingIsoprostanes, a marker of lipid peroxidation, may not be involved in the development of glucose intolerance.16956690
Glucose Intolerance (disease), Hepatitis CDeregulated Nutrient SensingIn conclusion, this community based study has shown that in a single population, chronic HCV infection is associated with glucose intolerance and, despite that, a favourable lipid pattern.16956918
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOverweight, hypertension, dyslipidemia (men only), smoking (men only), and diabetes (women only) contributed significantly to elevated hs-CRP levels.16963054
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOverweight individuals with hypertension, dyslipidemia, and diabetes had a high prevalence of elevated hs-CRP levels in both sexes.16963054
Hypertensive disease, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingMedical conditions such as coronary artery disease, arterial hypertension, and dyslipidemia did not diminish this recovery.16964557
Colorectal CarcinomaDeregulated Nutrient SensingVitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer.16965239
Primary malignant neoplasmDeregulated Nutrient SensingWe investigated interactions between foods (dairy products, red and processed meat, and whole and refined grains) and dietary patterns (sucrose-to-fiber ratio and glycemic index) associated with insulin resistance with the FokI polymorphism of the VDR gene and colon and rectal cancer risk.16965239
Postmenopausal state, Breast CarcinomaDeregulated Nutrient SensingThese results suggest a reduction in breast cancer risk for women with insulin resistance syndrome who consume high-fat diets and no association between specific sources of fat during midlife and risk of postmenopausal breast cancer.16968865
Diabetes MellitusDeregulated Nutrient SensingAn unchanged or increased GGT level over time, even when GGT is in the normal range, is correlated with increasing insulin resistance and is associated with a risk of incident type 2 diabetes in both sexes, independently of baseline GGT, which is itself a diabetes risk factor.16969645
Electrocardiogram: left ventricle hypertrophy (finding), ObesityDeregulated Nutrient SensingInsulin resistance and fasting insulin is not associated with left ventricular hypertrophy in healthy people, independent of obesity.16970048
Diabetes MellitusDeregulated Nutrient SensingLong-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetes.16970952
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDevelopment of insulin resistance (IR) and the progressive failure of the pancreatic beta-cell function (BCF) may be important in the pathogenesis of type 2 diabetes.16970952
Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingSimilarly, of all subjects with hypertension, 29.1% had diabetes (known or newly diagnosed) and 43.0% had glucose intolerance of some form.16978379
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity, insulin resistance and type 2 diabetes are linked to increased TNF-alpha action.16979382
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma DS-TNFR2 concentration was significantly decreased among patients with glucose intolerance or type 2 diabetes mellitus (p=0.026).16979382
Dyslipidemias, Disease of capillaries, Diabetes Mellitus, macroangiopathy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 1 diabetes is associated with a favorable lipid pattern and with microangiopathy, which is not true for type 2 diabetes, which is related to dyslipidemia and macroangiopathy.16981430
Prostate carcinomaDeregulated Nutrient SensingAndrogen deprivation therapy with a gonadotropin-releasing hormone (GnRH) agonist is associated with increased fat mass and insulin resistance in men with prostate cancer, but the risk of obesity-related disease during treatment has not been well studied.16983113
Coronary Artery Disease, Left ventricular ejection fractionDeregulated Nutrient SensingMyocardial insulin resistance (IR) is a feature of coronary artery disease (CAD) with reduced left ventricular ejection fraction (LVEF).16984986
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, ObesityDeregulated Nutrient SensingA total of 151 middle-aged men and women, with hypertension, dyslipidemia, type 2 diabetes, or obesity were enrolled.16990155
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia and insulin resistance (IR) are risk factors for coronary heart disease (CHD) in adults.16990559
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingUsing either criterion, diabetes was identified in 265 (9.6%) subjects and glucose intolerance in 568 (20.5%) subjects.16990663
DyslipidemiasDeregulated Nutrient SensingAdditionally, Cpn seropositivity was significantly associated with dyslipidemia and elevated IL-6, known risk factors for CAD.17000560
Hypotension, CTCAE, Dyslipidemias, Kidney Failure, Cervical Intraepithelial NeoplasiaDeregulated Nutrient SensingOn univariate logistic analysis, age, pre-existing renal insufficiency, intra-aortic balloon pump (an indirect indicator of haemodynamic instability), dyslipidaemia, and postprocedural hypotension were risk indicators for the development of CIN after primary PCI.17001234
HypothyroidismDeregulated Nutrient SensingAlthough insulin resistance in thyroid hormone excess is well documented, information on insulin action in hypothyroidism is limited.17003097
Lipodystrophy, deficiency aspects, Fatty LiverDeregulated Nutrient SensingLipin deficiency causes lipodystrophy, fatty liver, and insulin resistance in mice, whereas adipose tissue lipin overexpression results in increased adiposity but improved insulin sensitivity.17003347
ObesityDeregulated Nutrient SensingLipin expression in skeletal muscle, however, was not related to obesity or insulin resistance.17003347
Inflammation, Hypertension, CTCAE, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingThe ramifications of these findings with respect to insulin resistance, sympathetic tone, inflammation and hypertension, often associated with pathologic atrial fibrillation, are discussed.17005327
Kidney Failure, Chronic, AtherosclerosisDeregulated Nutrient SensingDespite the favourable effects of adiponectin on the vasculature and insulin resistance (IR), levels are increased in patients with end-stage kidney disease (ESKD), in whom both IR and atherosclerosis are prevalent.17005524
Glucose Intolerance (disease), Liver diseases, Peripheral Neuropathy, HyperuricemiaDeregulated Nutrient SensingOne patients had the complication of central and peripheral neuropathy, One patients had the complication of glucose intolerance, One patients had the complication of chronic hepatopathy and hyperuricaemia.17007380
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone.17007957
atheroscleroticDeregulated Nutrient SensingInsulin resistance is related to the atherosclerotic process.17007957
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this study, we examined the association between endothelial function and insulin resistance in 48 subjects with type 2 diabetes.17007957
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThere is a significant association between vascular endothelial dysfunction and insulin resistance in type 2 diabetes.17007957
Glucose Intolerance (disease), Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis increase in association with other cardiovascular risk factors that include dyslipidemia, insulin resistance, glucose intolerance, type II diabetes mellitus, suggest the necessity of accurate prevention strategies.17008856
Cardiovascular morbidity, Dyslipidemias, Kidney FailureDeregulated Nutrient SensingPatients with dyslipidemia and advanced renal failure are at markedly increased risk of cardiovascular morbidity and mortality.17009078
Endothelial dysfunction, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIt has been postulated that high serum concentrations of adiponectin, an emerging biomarker that is linked to insulin resistance and endothelial dysfunction, may be protective against T2DM and CHD.17010797
HostilityDeregulated Nutrient SensingHostility and urine norepinephrine interact to predict insulin resistance: the VA Normative Aging Study.17012525
HostilityDeregulated Nutrient SensingPrevious research has produced mixed results pertaining to the association between hostility and insulin resistance.17012525
HostilityDeregulated Nutrient SensingWe hypothesized that hostility may interact with circulating norepinephrine (NEPI) levels, indexed by 24-hour urine concentrations, to affect insulin resistance.17012525
HostilityDeregulated Nutrient SensingIndividuals with high stress and high hostility were more likely to have insulin resistance.17012525
OverweightDeregulated Nutrient SensingAlthough markedly overweight, the glucose tolerance was normal and insulin levels indicated no remarkable insulin resistance on the 75 g oral glucose tolerance test.17016000
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingObese patients, particularly the class III obese, were significantly younger and had higher prevalence of diabetes, hypertension, and dyslipidemia (P < 0.0001).17020562
Hyperlipidemia, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingThe obese children were studied according to coexistence of hypertension, hyperlipidemia, positive family history of cardiovascular diseases and insulin resistance.17020652
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt is hypothesized that proinflammatory cytokines contribute to atherogenesis, peripheral insulin resistance, and the development of hypertension and type II diabetes.17021763
ObesityDeregulated Nutrient SensingInsulin resistance plays an important role in the development of obesity.17026496
No metabolic abnormalities, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and associated metabolic abnormalities occur more commonly in the overweight/obese, and these changes increase the risk of cardiovascular disease (CVD).17027570
Hypertensive (finding), Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMore than half (51%) were hypertensive, whereas 28% had dyslipidemia, 56% were past or current smokers, and 6% had diabetes.17027581
Diabetes MellitusDeregulated Nutrient SensingOur objective was to delineate the potential role of adipogenesis in insulin resistance and type 2 diabetes.17030965
OverweightDeregulated Nutrient SensingThe effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese.17031391
OverweightDeregulated Nutrient SensingTo evaluate if CLA as a mixture of the main isomers trans-10 cis-12 and cis-9 trans-11 affects the insulin resistance in healthy overweight and obese male and female adults.17031391
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingThe suggested correlation between a T-to-C transition at the nucleotide 16189 in mitochondrial DNA (mtDNA) with increasing insulin resistance and adult-onset diabetes mellitus (DM) is debatable.17032725
Sleep Apnea, ObstructiveDeregulated Nutrient SensingOSAS is associated with reduced levels of adiponectin independently of insulin-resistance and BMI.17033258
Hypertension, CTCAE, Peripheral Arterial Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTo avoid confounding factors, conditions known to affect endothelial function like diabetes mellitus, hypertension, dyslipidemia, smoking, coronary and peripheral artery disease were excluded from both groups.17036158
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingActually, 35% of all AMI patients do not survive the first day after acute onset and in up to 90% of them classic risk factors (hypertension, dyslipidemia, diabetes, cigarette smoking) were present.17039323
Hyperglycemia, ObesityDeregulated Nutrient SensingLipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.17040956
ObesityDeregulated Nutrient SensingResistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents.17040961
Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding), ObesityDeregulated Nutrient SensingSex-related differences in the relations of insulin resistance and obesity to left ventricular hypertrophy in Japanese hypertensive patients.17044662
Left Ventricular Hypertrophy, ObesityDeregulated Nutrient SensingBoth insulin resistance and obesity have a well-known association with LV hypertrophy.17044662
Hypertensive (finding), ObesityDeregulated Nutrient SensingWe enrolled 91 never-treated hypertensive patients (49 men and 42 women) to assess the possible relations of insulin resistance and obesity to LV geometry.17044662
Left Ventricular Hypertrophy, Hypertensive (finding), ObesityDeregulated Nutrient SensingIn conclusion, these findings indicate the presence of sex-related differences in the relations of insulin resistance and obesity to LV hypertrophy in Japanese hypertensive patients.17044662
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingPrevalence of dyslipidemia in non-obese prepubertal children and its association with family history of diabetes, high blood pressure, and obesity.17045120
Dyslipidemias, ObesityDeregulated Nutrient SensingBecause obesity masks the need for screening, there is no previous description of dyslipidemia in healthy normal-weight children.17045120
Nonesterified Fatty Acids Measurement, Cardiomyopathy, Familial Idiopathic, Ventricular DysfunctionDeregulated Nutrient SensingDecreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction.17045185
Heart failureDeregulated Nutrient SensingInsulin resistance, a common comorbidity in heart failure patients, and medical therapy may modify myocardial metabolism in complex fashions.17045185
Cardiomyopathy, Familial IdiopathicDeregulated Nutrient SensingTherefore, we characterized myocardial oxidative and free fatty acid (FFA) metabolism in patients with idiopathic dilated cardiomyopathy (IDCM) and investigated the contributions of insulin resistance and beta-blocker therapy.17045185
Depressed moodDeregulated Nutrient SensingHowever, when LV function is further depressed and insulin resistance manifested, myocardial FFA uptake and oxidation are, in turn, upregulated.17045185
HypoadiponectinemiaDeregulated Nutrient SensingHypoadiponectinemia is significantly associated with cardiovascular risk factors such as insulin resistance and atherogenic lipid profiles in nonobese, apparently healthy subjects.17046559
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingAdiponectin levels are significantly lower in obese adult patients with type 2 diabetes mellitus, essential hypertension, dyslipidemia, and cardiovascular disease.17046559
ObesityDeregulated Nutrient SensingA common genetic background contributes to the clustering of different MSX component traits and central obesity or insulin resistance.17047637
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus.17048191
OverweightDeregulated Nutrient SensingInsulin resistance, oxidative stress markers and the blood antioxidant system in overweight elderly men.17050115
HyperglycemiaDeregulated Nutrient SensingIt was indicated that the increased insulin resistance and hyperglycemia in elderly men are related to body mass and that they cause intensified oxidative modifications of LDL.17050115
SchizophreniaDeregulated Nutrient SensingWe conducted a prospective, open study comparing body weight, parameters of insulin resistance in schizophrenia patients treated with either clozapine (n = 10) or amisuLpride ( n = 12).17050656
DyslipidemiasDeregulated Nutrient SensingRosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia.17050799
DyslipidemiasDeregulated Nutrient SensingCharacteristics predicting dyslipidemia in drug-naive type 2 diabetes patients.17051750
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe necessity of treatment for dyslipidemia increased with the duration of diabetes.17051750
Hyperlipidemia, Dyslipidemias, ObesityDeregulated Nutrient SensingEffect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia.17054424
Aortic arch structure, DyslipidemiasDeregulated Nutrient SensingMultivariate logistic regression analysis showed that two factors had an independent predictive value of positive DSE: aortic arch atheroma (p = 0.007) and dyslipidemia (p = 0.09).17057380
Steatohepatitis, Hepatitis C, Chronic, NecrosisDeregulated Nutrient SensingHepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor-alpha in chronic hepatitis C patients.17059516
Fatty degenerationDeregulated Nutrient SensingSteatosis and insulin resistance (IR) have a pathogenic role in chronic hepatitis C (HCV).17059516
Inflammation, DyslipidemiasDeregulated Nutrient SensingMoreover, uric acid level was associated with calcium/phosphate metabolism, dyslipidemia, and inflammation.17059995
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance and blood pressure circadian variation in an obese hypertensive population.17060061
Damage, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance (IR) is related to arterial hypertension and target organ damage.17060061
Antihypertensive AgentsDeregulated Nutrient SensingInsulin resistance is not associated with nocturnal blood pressure reduction in obese hypertensives.17060061
Malignant neoplasm of endometrium, Diabetes Mellitus, Non-Insulin-Dependent, Polycystic Ovary Syndrome, ObesityDeregulated Nutrient SensingAdiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer.17062769
Fibrosis Assessment, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingLeptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease.17062890
HyperglycemiaDeregulated Nutrient SensingTCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.17065361
Diabetes MellitusDeregulated Nutrient SensingWhile high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas.17065666
Increased insulin level, Cardiovascular DiseasesDeregulated Nutrient SensingTrends in hyperinsulinemia among nondiabetic adults in the U.S. Insulin resistance and compensatory hyperinsulinemia have been proposed as increasing risk for a variety of abnormalities and clinical syndromes, including type 2 diabetes and cardiovascular disease.17065674
ObesityDeregulated Nutrient SensingObesity in U.S. adolescents represents the most important risk factor for insulin resistance, independent of sex, age, or race/ethnicity.17065679
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of insulin resistance in obese children foreshadows a worrisome trend for the burden of type 2 diabetes in the U.S.17065679
Diabetes MellitusDeregulated Nutrient SensingThe dysregulation of adipokines is closely associated with the pathogenesis of insulin resistance and type 2 diabetes.17065684
ObesityDeregulated Nutrient SensingRetinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance.17065684
Diabetes MellitusDeregulated Nutrient SensingPlasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance.17065684
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingLow levels are associated with obesity, insulin resistance, and type 2 diabetes.17065691
Diabetes MellitusDeregulated Nutrient SensingIn the context of diabetes, ROS is suggested to trigger different forms of insulin resistance involving different mechanisms.17066297
Bipolar DisorderDeregulated Nutrient SensingAssociations between depressive symptoms and insulin resistance: the Hoorn Study.17066302
Depression, CTCAEDeregulated Nutrient SensingThe association between depression and insulin resistance has been investigated in only a few studies, with contradictory results reported.17066302
Bipolar DisorderDeregulated Nutrient SensingThe association between depressive symptoms and insulin resistance was similar for men and women.17066302
Bipolar DisorderDeregulated Nutrient SensingWe found only weak associations between depressive symptoms and insulin resistance, which did not differ among different glucose metabolism subgroups or between men and women.17066302
Hashimoto Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Hashimoto's hypothyroidism associated with insulin resistance in type 2 diabetes].17066592
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingDyslipidemic patients show a worse compliance than hypertensive patients, and dyslipidemia worsened global compliance in hypertensive patients.17067241
Hypokalemia, SeizuresDeregulated Nutrient SensingHypokalemia (P= 0.001) and insulin resistance (P= 0.025) were more common and seizures (P= 0.01) less frequently reported with the use of TH.17067329
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOf 600 men who received a single 10 mg dose of vardenafil, 32% had hypertension, 16% had diabetes and 19% had dyslipidaemia.17073835
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFirst-dose SEP-2 and SEP-3 success rates were 84% and 66% in men with hypertension (n = 191); 84% and 72% in men with dyslipidaemia (n = 116); and 75% and 58% in men with diabetes (n = 95).17073835
Primary malignant neoplasm, ObesityDeregulated Nutrient SensingImpact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study.17075121
Primary malignant neoplasm, ObesityDeregulated Nutrient SensingAlthough many studies have demonstrated that smoking, alcohol, obesity, and insulin resistance are risk factors for cancer, the role of those factors on cancer survival has been less studied.17075121
Diagnosis, Primary malignant neoplasm, ObesityDeregulated Nutrient SensingPrediagnosis risk factors for cancer development (smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients.17075121
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSouth Asian adults are known to have very high rates of Coronary heart disease (CHD) and insulin resistance and, even as adolescents, may show higher risk factors for CHD.17077065
Pancreatic enzyme, Dyslipidemias, PancreasDeregulated Nutrient SensingCan pancreatic steatosis explain the finding of pancreatic hyperenzymemia in subjects with dyslipidemia?17079938
Pancreatic enzyme, Dyslipidemias, Pancreas, Fatty degenerationDeregulated Nutrient SensingIt has been proposed by some investigators that benign pancreatic hyperenzymemia could result from pancreatic steatosis that they believe would have been caused by dyslipidemia; their diagnosis of steatosis was based on the finding of a hyperechogenic pancreas at ultrasound.17079938
Pancreatic enzyme, DyslipidemiasDeregulated Nutrient SensingIn addition, 6 subjects with benign pancreatic hyperenzymemia but who did not have dyslipidemia or hyperechogenic pancreas and 10 healthy subjects with none of these conditions were also studied as controls.17079938
Dyslipidemias, Fatty infiltrationDeregulated Nutrient SensingMagnetic resonance imaging showed normal pancreas with no signs of fatty infiltration in all 18 subjects with dyslipidemia, including those with both dyslipidemia and hyperechogenic pancreas at ultrasound.17079938
Pancreatic enzyme, Dyslipidemias, PancreasDeregulated Nutrient SensingThe finding of a completely normal pancreas at magnetic resonance imaging does not support the proposed model in which pancreatic hyperenzymemia in subjects with dyslipidemia is attributed to pancreatic steatosis.17079938
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Hypertension, CTCAE, Mental disordersDeregulated Nutrient SensingThere were significant associations between increased severity of ED and presence of diabetes, hypertension, dyslipidemia, ischemic heart disease, myocardial infarction, and psychological disorders.17081221
Hypertension, CTCAE, Diabetic Angiopathies, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe higher risk for lower esRAGE was still significant even after adjusted either with body mass index, hypertension, dyslipidemia and vascular complications, but was confounded by age and diabetes.17082489
Chronic Kidney DiseasesDeregulated Nutrient SensingPrevious research has reported reduced serum 25-hydroxyvitamin D levels in patients with chronic kidney disease (CKD), although the relationship between vitamin D status and insulin resistance (IR) in patients with CKD has not been examined in the general population.17082756
Obesity, Abdominal, Dyslipidemias, ObesityDeregulated Nutrient SensingIn conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.17087055
Myocardial IschemiaDeregulated Nutrient SensingThe investigation was performed in three groups of subjects with a different prevalence of insulin resistance: 72 non-diabetics with ischemic heart disease, 117 young blood donors and 63 type 2 diabetics on diet therapy only.17087600
Abnormal circulating valine concentration, Diabetes Mellitus, Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits.17091361
Sandawe languageDeregulated Nutrient SensingWaist circumference and SAD were positively correlated with leptin and insulin resistance and negatively correlated with adiponectin.17093174
Weight decreasedDeregulated Nutrient SensingAfter moderate weight loss, midthigh subcutaneous AT, IAT, low-density lean tissue, leptin, and insulin resistance decreased significantly; no significant changes in adiponectin were observed.17093174
Weight decreased, InfiltrationDeregulated Nutrient SensingEven in older women, moderate weight loss improves body fat distribution, muscle lipid infiltration, and insulin resistance.17093174
Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolism, Diabetes MellitusDeregulated Nutrient SensingMitochondrial dysfunction and increased intramyocellular lipid (IMCL) content have both been implicated in the development of insulin resistance and type 2 diabetes mellitus, but the relative contributions of these two factors in the aetiology of diabetes are unknown.17093944
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe finding that in vivo mitochondrial function is decreased in type 2 diabetes patients compared with controls whereas IMCL content is similar suggests that low mitochondrial function is more strongly associated with insulin resistance and type 2 diabetes than a high IMCL content per se.17093944
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity, hypertension and dyslipidaemia were present in most patients, diabetes in 17.3% of them.17096010
Glucose Intolerance (disease)Deregulated Nutrient SensingThe first 6 months after birth may be the most critical period for growth, in relation to development of glucose intolerance.17096117
Fever, CTCAE, Coughing, Dyslipidemias, Anemia, DyspneaDeregulated Nutrient SensingThe patients presented with fever, cough, dyspnea, anemia, and dyslipidemia.17097960
Hypertension, CTCAEDeregulated Nutrient SensingHypertension, body mass index (BMI), and non-Caucasian self-identity were directly related to insulin resistance (IR); however, age, CD4 lymphocyte count, and rates of treatment with HAART were not.17099311
Hypoadiponectinemia, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingHypoadiponectinemia has been implicated in the development of obesity-related conditions, including dyslipidemia and coronary heart disease (CHD).17101706
Coinfection, Lipodystrophy, Hepatitis CDeregulated Nutrient SensingAmong HIV-infected patients, hepatitis C virus (HCV) coinfection is associated with increased rates of lipodystrophy and insulin resistance.17105512
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingAfter controlling for duration of protease inhibitor (PI) therapy, race, alanine aminotransferase (ALT) concentration and platelet count, HCV remained an independent predictor of hypercholesterolaemia (RR=0.369; P=0.01) and any dyslipidaemia (RR=0.531; P=0.019).17105512
DyslipidemiasDeregulated Nutrient SensingHCV coinfection independently predicted lower rates of dyslipidaemia among HIV-infected patients.17105512
DyslipidemiasDeregulated Nutrient SensingIn addition, the rate of dyslipidaemias was lower among HCV-monoinfected than HIV/HCV-coinfected patients (29.5% vs 50.5; P=0.002).17105512
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe area under the receiver-operating characteristic curve for WHtR was significantly higher than for all other anthropometric parameters with respect to all risk conditions in women and to dyslipidemia and type 2 diabetes in men.17105840
Hypertriglyceridemia, Metabolic Syndrome XDeregulated Nutrient SensingOur results suggest that genetic variation at the eNOS locus is associated with features of metabolic syndrome, and might represent a new genetic susceptibility component for insulin resistance, hypertriglyceridemia, and low HDL-cholesterol concentrations.17110473
TG gene, CD55 gene, Dyslipidemias, Family historyDeregulated Nutrient SensingWe compared the obtained serum lipid profile with that of the Lipid Research Clinic (LRC) and calculated the predictive value of FH for detecting those children with dyslipidemia.Overall, for both genders and for age groups, the mean serum triglycerides (TG) and its percentiles were significantly higher, and the mean and percentiles of total, low-density, and high-density cholesterol (TC, LDL-C, and HDL-C respectively) were significantly lower than the LRC values.17111289
Dyslipidemias, Family historyDeregulated Nutrient SensingThe sensitivity, and specificity, positive and negative predictive values for FH in detecting those children with dyslipidemia were 28.4, 70.3.17111289
ObesityDeregulated Nutrient SensingOlder lean women showed lower levels of ghrelin (p<0.05) than young lean women, with no differences regarding BP, obesity, lipids, adipokines or insulin resistance (IR).17113660
HypertrophyDeregulated Nutrient SensingIts lower increase may be due, in addition to the characteristics of their chest walls, to insulin resistance which may limit the increase in lactic acid during effort, and to the hypertrophy of muscle fibers previously noted, which may be linked to a lower increase in plasma K(+) during physical exercise.17114876
Diabetes MellitusDeregulated Nutrient SensingHaemoglobin A1c is not a surrogate for glucose and insulin measures for investigating the early life and childhood determinants of insulin resistance and Type 2 diabetes in healthy children.17116188
Diabetes MellitusDeregulated Nutrient SensingResearch into early life and childhood determinants of insulin resistance and Type 2 diabetes are complicated by requirements for fasting blood samples and glucose tolerance tests.17116188
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAbdominal obesity and insulin resistance in patients with type 2 diabetes in a Swedish community.17118860
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo explore the association between abdominal obesity and insulin resistance in patients with type 2 diabetes.17118860
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWC provides a feasible measure for insulin resistance in the vast majority of subjects with type 2 diabetes.17118860
Obesity, NephrolithiasisDeregulated Nutrient SensingFuture research should focus on more obese subjects in whom insulin resistance and particular kidney functions should also be examined to further substantiate the role of obesity in low-urine pH-associated conditions, for example, nephrolithiasis.17119545
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese findings suggest that leptin resistance exists in patients with NAFLD and leptin resistance is positively correlated with NAFLD, the same as in insulin resistance.17125610
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingRelationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people.17129741
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe common Leu162Val polymorphism in the gene encoding PPARalpha has inconsistently shown association with quantitative traits related to obesity, type 2 diabetes, and dyslipidaemia.17129741
DyslipidemiasDeregulated Nutrient SensingIn addition, the Leu162Val polymorphism was not associated with WHO-defined obesity or dyslipidaemia in case-control settings involving 961 obese and 2563 lean subjects and 1399 dyslipidaemic and 4399 normolipidaemic subjects, respectively.17129741
Presenile dementia, Impaired cognitionDeregulated Nutrient SensingInsulin resistance is a potentially modifiable midlife risk factor for cognitive decline and dementia.17130206
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance, inflammatory biomarkers, and adipokines in patients with chronic kidney disease: effects of angiotensin II blockade.17130263
Chronic Kidney DiseasesDeregulated Nutrient SensingPatients with chronic kidney disease (CKD) present a high prevalence of insulin resistance (IR).17130263
Dyslipidemias, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingAlthough substantial evidence suggests that treatment of dyslipidemia with statins reduces mortality and morbidity that are associated with cardiovascular disease, only a few studies have examined the efficacy of statins on inflammatory and fibrinolytic status in patients with chronic kidney disease (CKD).17130267
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingThe long-term impact of dietary carbohydrate type, in particular sucrose, on insulin resistance and the development of diabetes and atherosclerosis is not established.17130505
LipodystrophyDeregulated Nutrient SensingGastric bypass for insulin resistance due to lipodystrophy.17132423
LipodystrophyDeregulated Nutrient SensingWe report a 41-year-old woman with severe insulin resistance due to partial lipodystrophy, who was successfully treated with gastric bypass surgery.17132423
AtherosclerosisDeregulated Nutrient SensingCarbohydrate nutrition, glycaemic load, and plasma lipids: the Insulin Resistance Atherosclerosis Study.17132647
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertrophy, Hypertension, CTCAEDeregulated Nutrient SensingReduced eGFR was associated with increased prevalence of established cardiovascular risk factors [cardiovascular disease, diabetes, hypertension, left ventricular (LV) hypertrophy, and dyslipidaemia] and higher levels of inflammatory markers [interleukin 6 (IL-6), C-reactive protein], endothelial markers [von Willebrand factor (vWF) and tissue plasminogen activator], activated coagulation markers (fibrin D-dimer), and blood viscosity.17132648
Kidney Failure, Chronic, diabeticDeregulated Nutrient SensingPrevalence, severity and predictors of HOMA-estimated insulin resistance in diabetic and nondiabetic patients with end-stage renal disease.17136689
Kidney Failure, Chronic, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevalence of insulin resistance (IR) is increased in type 2 diabetes and in end-stage renal disease (ESRD).17136689
Hyperglycemia, Postprandial, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingThis case suggests that postprandial hyperglycemia and insulin resistance might be one of the possible underlying mechanisms of paroxysmal atrial fibrillation.17136822
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThe utility of non-HDL in managing dyslipidemia of stage 5 chronic kidney disease.17140163
Hypertriglyceridemia, Dyslipidemias, Coronary heart disease, Kidney Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingThe Kidney Disease Outcomes Quality Initiative (K/DOQI) treatment guidelines for managing dyslipidemia in patients with chronic kidney disease (CKD) designate CKD as a high-risk category for coronary heart disease and, in Stage 5 CKD patients, recommend maintaining low-density lipoprotein (LDL) < 100 mg/dl and, for patients with hypertriglyceridemia (> or = 200 mg/ dl), non-high-density lipoprotein (non-HDL) < 130 mg/dl, the latter to achieve very low-density lipoprotein (VLDL) < 30 mg/dl.17140163
Chronic Kidney Diseases, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingIn Stage 5 CKD patients at hemodialysis inception, dyslipidemia is highly prevalent with predominance of the atherogenic triad (hypertriglyceridemia, elevated VLDL and reduced HDL).17140163
SteatohepatitisDeregulated Nutrient SensingIntake of nutrients strongly affects insulin resistance, carbohydrate and lipid metabolism, and hepatic steatosis.17140767
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with at least two cardiovascular risk factors in addition to dyslipidemia (primary prevention) or with past cardiovascular disease (secondary prevention) were recruited by general practitioners (GPs).17141490
Carotid Intima-Media ThicknessDeregulated Nutrient SensingWe measured the carotid intima-media thickness (IMT), LDL particle size, and insulin resistance in 136 nondiabetic subjects.17142132
AtherosclerosisDeregulated Nutrient SensingWe conclude that LDL particle size was associated with insulin resistance, but age, triglyceride, and HDL-C contributed independently to the variability in LDL particle size, and LDL particle size was not a predictor of preclinical atherosclerosis in nondiabetic Koreans.17142132
Weight decreased, Carotid Intima-Media ThicknessDeregulated Nutrient SensingIn the 24 obese children with substantial weight loss, intima-media thickness, blood pressure, triglycerides, insulin, and insulin resistance index decreased significantly, whereas high-density lipoprotein cholesterol increased significantly.17142516
Weight decreasedDeregulated Nutrient SensingIn the 32 obese children without substantial weight loss, there were no significant changes apart from an increase of insulin and insulin resistance index.17142516
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAmong the offspring, lower birthweight was associated with an increased risk of glucose intolerance (impaired glucose tolerance, impaired fasting glucose or type 2 diabetes) and higher cholesterol and triacylglycerol concentrations (p < 0.05 for all adjusted for sex and age).17143606
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlternate-day dosing of atorvastatin: effects in treating type 2 diabetic patients with dyslipidaemia.17143784
AtherosclerosisDeregulated Nutrient SensingAssociation of insulin resistance with distance to wealthy areas: the multi-ethnic study of atherosclerosis.17148499
Vascular calcificationDeregulated Nutrient SensingLeptin is associated with adiposity and insulin resistance and may play a direct role in vascular calcification.17148566
Hyperglycemia, Dyslipidemias, InflammationDeregulated Nutrient SensingThe variability of hyperglycemia, dyslipidemia, and inflammation with age progression was also studied for comparison.17151300
Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Heart Diseases, ObesityDeregulated Nutrient SensingHyperglycemia showed no variability with age whereas dyslipidemia correlated positively with age progression, as well as obesity, low physical activity, and family history of heart disease or diabetes.17151300
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingSwitch to 1.5 grams MMF monotherapy for CNI-related toxicity in liver transplantation is safe and improves renal function, dyslipidemia, and hypertension.17154392
Renal Insufficiency, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingWe attempted the complete weaning off CNI in 42 individuals presenting chronic renal dysfunction and/or dyslipidemia and/or arterial hypertension and simultaneously introduced 1.5 gm/day MMF.17154392
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingStrain gradient significantly decreased in parallel with the presence of dyslipidemia and/or type 2 diabetes.17158335
Dyslipidemias, CardiomyopathiesDeregulated Nutrient SensingThe groups were similar in respect to race, creatinine, cholesterol, and history of dyslipidemia and cardiomyopathy.17161055
Diabetes Mellitus, diabetic, Obesity, Hypertension, CTCAE, Complications of Diabetes MellitusDeregulated Nutrient SensingOur results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies.17161225
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis suggests that glucose intolerance (type 2 diabetes mellitus) is an important factor that disturbs Cr metabolism.17161231
Coronary Artery Disease, Heart failureDeregulated Nutrient SensingPatients with coronary artery disease and heart failure exhibit myocardial insulin resistance, and this is greater in those with T2DM.17161251
Inflammation, physiopathological, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance, inflammation, and blood pressure determine vascular dysfunction in CKD.17162147
Inflammation, Dyslipidemias, Systolic hypertension, physiopathological, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance, inflammation, systolic hypertension, and increased pulse pressure, but not dyslipidemia, were associated with vascular dysfunction and may be targets for future interventional strategies to reduce CVD risk in patients with CKD.17162147
Colorectal CarcinomaDeregulated Nutrient SensingInsulin, glucose, insulin resistance, and incident colorectal cancer in male smokers.17162243
Increased insulin level, Colorectal Carcinoma, HyperglycemiaDeregulated Nutrient SensingData from this prospective study of male smokers provide limited support for hyperinsulinemia, hyperglycemia, and/or insulin resistance as CRC risk factors.17162243
Obesity, AbdominalDeregulated Nutrient SensingInsulin resistance appears to be a weak determinant of DM in Turkish women while abdominal obesity is the main determinant.17162275
Weight decreasedDeregulated Nutrient SensingReductions in circulating RBP-4 may contribute to improved insulin resistance in morbidly obese subjects after weight loss.17164313
Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingThe effect of fluvastatin on cICAM-1 as a biomarker of endothelial dysfunction in patients with dyslipidemia.17164750
Dyslipidemias, diabeticDeregulated Nutrient SensingIn type 2 diabetic patients, tesaglitazar dose-dependently reduced FPG levels at doses > or = 0.5 mg. Other markers of glycemic control, atherogenic dyslipidemia, and measures associated with insulin resistance were improved at doses > or = 0.5 mg or > or = 1.0 mg. Study limitations included that the majority of patients were white, patients had good glycemic control at baseline, and the increased number of early withdrawals in the tesaglitazar 2.0 mg and 3.0 mg doses limits conclusions about the efficacy of these doses.17166340
HyperglycemiaDeregulated Nutrient Sensing[Study of relationship between stress hyperglycemia and insulin-resistance related factors].17166359
HyperglycemiaDeregulated Nutrient SensingTo observe related factors in the stress hyperglycemia (SHG) of critical illness and to investigate possible pathogenesis of insulin-resistance (IR).17166359
IGA GlomerulonephritisDeregulated Nutrient SensingInsulin resistance and the progression of IgA glomerulonephritis.17166857
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingInsulin resistance was associated with obesity but not with PCOS.17166864
Tumor necrosisDeregulated Nutrient SensingTumor necrosis factor-alpha (TNF-alpha) has an increased expression in the adipose tissue of obese subjects and is involved in insulin resistance.17167711
Obesity, AtherosclerosisDeregulated Nutrient SensingResistin (RSN) is an adipocytokine involved in insulin resistance, obesity and atherosclerosis.17173885
Diabetes MellitusDeregulated Nutrient SensingOur data suggest that noncoding SNPs may increase diabetes susceptibility in Caucasians and may contribute to insulin resistance and reduced insulin secretion.17174134
Congestive heart failureDeregulated Nutrient SensingInsulin resistance is present in the setting of congestive heart failure.17174230
ObesityDeregulated Nutrient SensingLittle is known about obesity and insulin resistance in college students.17175904
ObesityDeregulated Nutrient SensingLeptin is a hormone secreted by fat cells and has been shown to strongly correlate with both obesity and insulin resistance in children and adults.17175904
ObesityDeregulated Nutrient SensingLeptin was associated with fasting insulin (beta+/-SE = 0.30+/-0.06, p < .001) and insulin resistance (beta+/-SE = 0.41+/-0.20, p < .001) independent of total fat, gender, and age, suggesting other mechanisms of leptin and insulin regulation besides obesity.17175904
AtherosclerosisDeregulated Nutrient SensingAdiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly.17178123
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAmelioration of insulin resistance could improve both glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus.17178700
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingThe age-adjusted prevalences of hypertension, dyslipidaemia and overweight in males were significantly higher (p < 0.001) than in females.17180353
Bowens DiseaseDeregulated Nutrient SensingStrong expression of a longevity-related protein, SIRT1, in Bowen's disease.17180656
Primary malignant neoplasmDeregulated Nutrient SensingSIRT1 regulates cell survival via deacetylation of p53 and forkhead transcription factors, and overexpression of SIRT1 is reported to be essential for cell growth and survival in some kinds of cancer.17180656
Skin carcinomaDeregulated Nutrient SensingOverexpression of SIRT1 is frequently observed in all kinds of non-melanoma skin cancers included in this study.17180656
Skin CarcinogenesisDeregulated Nutrient SensingIn addition, no obvious difference between AK and SCC was observed in the expression of SIRT1, suggesting that overexpression of SIRT1 may have some relevance to the early stage of skin carcinogenesis.17180656
Skin carcinomaDeregulated Nutrient SensingWe suppose that SIRT1 could be one of the critical targets for future therapy with the aim of inhibiting cell proliferation and promoting apoptosis in non-melanoma skin cancers.17180656
Increased insulin level, Primary malignant neoplasm, Inflammation, Depressed moodDeregulated Nutrient SensingThese lifestyle patterns may increase cancer risk by several mechanisms including increased estrogens and testosterone, hyperinsulinemia and insulin resistance, increased inflammation, and depressed immune function.17182820
ETV3 wt Allele, Congestive heart failureDeregulated Nutrient SensingMetS was associated with about a twofold increased likelihood of self-reported CHF and it may serve as a surrogate indicator for the association between insulin resistance and CHF.17183018
Acute Coronary SyndromeDeregulated Nutrient SensingThe findings suggest that in this case the CD36 deficiency type 1 was the pathogenic mechanism of acute coronary syndrome relative to insulin resistance and modification of the lipid profile.17186996
Congestive heart failureDeregulated Nutrient SensingIndices of insulin resistance were higher amongst CHF patients compared with controls, with no ethnic variation.17187880
Congestive heart failureDeregulated Nutrient SensingOn multivariate regression analysis of patients and healthy controls, CHF was independently associated with smoking habit, adiponectin and insulin resistance (all P<0.01).17187880
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingParticular attention is given to dyslipidemia, blood pressure, diabetes mellitus, and tobacco cessation.17189584
Dyslipidemias, SimultaneousDeregulated Nutrient SensingThe main aim was to obtain data on the therapeutic approaches to patients observed in cardiology hospital outpatient clinics with high blood pressure and/or dyslipidemia as well as other concomitant diseases, in order to plan future wider-ranging studies and to analyze the main risk factors of cardiovascular conditions in this population.17190239
Dyslipidemias, Diabetes Mellitus, Pathology, Coronary heart diseaseDeregulated Nutrient SensingOf these patients, 87.7% had high blood pressure, 75.8% had dyslipidemia and 63.5 % had both pathologies; the prevalence of diabetes was high and that of coronary disease was very high.17190239
Depressed moodDeregulated Nutrient SensingThe herein presented longitudinal data do not exclude the HPA system as a major contributor to insulin resistance in depressed patients, but underscore the assumption of additional factors.17194262
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study.17194277
Dyslipidemias, ObesityDeregulated Nutrient SensingWe suggest that patients taking SSRIs be carefully monitored for obesity and dyslipidemia.17194277
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingDyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques: evidence for a corrective effect of statins.17196206
DyslipidemiasDeregulated Nutrient SensingIn patients with untreated dyslipidemia (ApoB/ApoA1 ratio >0.7) (D+) (n=44), TF antigen (TF) tended to be higher than in those without dyslipidemia (D-) (n=16).17196206
Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingAmong analyzed clinical risk factors and biological parameters, including CRP, dyslipidemia was the only independent predictor for low plaque TFPI and high TF/TFPI ratio.17196206
DyslipidemiasDeregulated Nutrient SensingThese results indicate that dyslipidemia is associated with a shift of the TF/TFPI balance and of TF activity toward higher plaque thrombotic potential.17196206
Cardiovascular Diseases, Microalbuminuria, Dyslipidemias, Diabetes Mellitus, diabetic, Obesity, Renal Insufficiency, Hypertension, CTCAEDeregulated Nutrient SensingImpaired renal function was 38.2% and 49.1% respectively in the subjects with diabetes and IGR; (3) The prevalence of microalbuminuria was significantly higher in the diabetic patients with hypertension, central obesity, dyslipidemia, history of cardiovascular disease or selinity.17198559
DyslipidemiasDeregulated Nutrient SensingThese data suggest that the dyslipidaemia previously attributed to smoking occurs primarily in those smokers who are also insulin resistant.17199720
ObesityDeregulated Nutrient SensingIntramuscular lipid content increases with aging and obesity and is directly related to impaired glucose tolerance and insulin resistance.17200170
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA high prevalence of coronary risk factors was present: systemic hypertension (64%), diabetes mellitus (40%), dyslipidemia (35%), smoking (33%) and previous CAD (32%).17203791
Glucose Intolerance (disease), Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingThese abnormalities in LV function were more common not only in subjects with diabetes, but also in patients with prediabetic condition, impaired glucose intolerance.17204040
TG gene, CD55 gene, Dyslipidemias, HypertriglyceridemiaDeregulated Nutrient SensingUrban men had a significantly higher prevalence of dyslipidemia (TC > or =240 and LDL-C > or = 60 mg/dl) than rural men (25.9 vs. .3.7 per cent for TC and 16.7 vs. 3.7 percent for LDL-C, p < 0.001) while the prevalence of hypertriglyceridemia (> or =200 mg/dl) and low HDL-C (< 40 mg/dl) was significantly higher in rural women (18.2 vs. 7.9 percent for TG and 15.0 vs. 3.8 per cent of HDL-C, p < 0.001).17205863
DyslipidemiasDeregulated Nutrient SensingMigration to urban centers and adopting an urban lifestyle is likely related to the rising lipid level and prevalence of dyslipidemia.17205863
ObesityDeregulated Nutrient SensingLack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile.17211557
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes.17211560
Congenital AbnormalityDeregulated Nutrient SensingThis situation may cause, at least in part, RBC-WBC function abnormalities and insulin resistance because of inconvenient membrane fluidity.17211560
Dyslipidemias, Diabetes Mellitus, Congestive heart failure, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingPreexisting medical conditions (hypertension, dyslipidemia, diabetes mellitus, congestive heart failure, chronic renal disease) also significantly affected the risk for CVEs.17213003
Diabetes MellitusDeregulated Nutrient SensingAs early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion.17213521
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe results of an age- and sex-adjusted logistic regression analysis indicated that BMI obesity was associated with dyslipidemia (p=0.04), WC obesity was associated with dyslipidemia (p=0.07), and 'obesity' was associated with diabetes (p=0.06) and dyslipidemia (p=0.01).17213689
Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to investigate the association between insulin resistance and physical fitness, leptin concentration, body composition and family history for diabetes in non-selected young children.17215165
Diabetes MellitusDeregulated Nutrient SensingThe influence of family history for diabetes on insulin resistance is shown as a trend at this age.17215165
TG geneDeregulated Nutrient SensingThe apo A-I/HDL cholesterol ratio significantly increased by 3% in men at 2:30 p.m. and by 5% both in men and women at 5:00 p.m. Postprandial serum TG were higher and HDL cholesterol and apo A-I were lower in subjects of both genders with insulin resistance (high HOMA(IR)) than in those with low HOMA(IR).17217150
Dental PlaqueDeregulated Nutrient SensingCompared to subjects identified by NCEP definition, subjects identified in excess by IDF (3.1-11.7%) showed less insulin resistance and lower IMT and plaque extent indistinguishable from MetS-free subjects.17217376
ETV3 wt Allele, AtherosclerosisDeregulated Nutrient SensingOur data suggest that the IDF definition includes subjects as MetS sufferers above these detected by NCEP or WHO, who exhibit considerably less insulin resistance and carotid atherosclerosis blurring the distinction between health and disease.17217376
Dyslipidemias, Ischemic stroke, Tacca leontopetaloidesDeregulated Nutrient SensingIdentification of dyslipidemia and treatment with lipid-lowering agents are established targets for quality performance during hospitalization for ischemic stroke and transient ischemic attack (TIA).17219502
Tacca leontopetaloides, Ischemic stroke, DyslipidemiasDeregulated Nutrient SensingMeasurement of LDL-C was most strongly and independently associated with diagnosis of ischemic stroke (vs. TIA, P = .02) and history of dyslipidemia (P = .05).17219502
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingIndependent predictors for being prescribed lipid-lowering agents at discharge were diagnosis of ischemic stroke (P = .0009), LDL-C testing (P = .0002), high risk of future coronary events according to national guidelines (P = .02), and history of dyslipidemia (P< .0001).17219502
Inflammation, Hypertension, CTCAEDeregulated Nutrient SensingOxidative stress (OS), inflammation and insulin resistance are among the mechanisms that have been recently implicated in pathogenesis of essential hypertension (EH).17220028
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEvaluation of glucose intolerance in adolescents relative to adults with type 2 diabetes mellitus.17220060
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingObesity and glucose intolerance are also a problem in developing countries.17220060
DyslipidemiasDeregulated Nutrient SensingEffect of atorvastatin on type 2 diabetic dyslipidemia.17220473
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is considered to play an important role in the development of cardiovascular disease, which limits long-term renal transplant survival.17220787
ObesityDeregulated Nutrient SensingOur results indicate that obesity, distribution of obesity, and prednisolone treatment are the predominant determinants of insulin resistance long term after transplantation.17220787
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance after renal transplantation could be managed favorably by weight and prednisolone dose reduction, which may reduce cardiovascular disease.17220787
Vascular System InjuriesDeregulated Nutrient SensingKey role of insulin resistance in vascular injury among hemodialysis patients.17224326
Hypertensive (finding), diabeticDeregulated Nutrient SensingInsulin resistance prevails not only among diabetic patients but also among hypertensive and obese patients.17224326
HD Term Type, Cardiovascular DiseasesDeregulated Nutrient SensingThe relationship between insulin resistance and cardiovascular diseases was investigated in hemodialysis (HD) patients.17224326
HD Term Type, Vascular System InjuriesDeregulated Nutrient SensingThe present results provide evidence that angiotensin inhibition improves insulin resistance, possibly preventing vascular injury in HD patients.17224326
HD Term TypeDeregulated Nutrient SensingFinally, our findings suggest that insulin resistance is prognostic of cardiovascular events in HD patients.17224326
ObesityDeregulated Nutrient SensingThe lack of association between inflammatory markers and HOMA-IR suggests that obesity may precede the elevation of these markers in the evolution of insulin resistance in youth.17224334
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensingglucose infusion, respectively, to further elucidate the mechanisms behind the glucose intolerance in patients with type 2 diabetes.17225124
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe suggest that this phenomenon contributes both to the glucose intolerance and to the reduced incretin effect observed in patients with type 2 diabetes.17225124
ObesityDeregulated Nutrient SensingReduced serum levels of adiponectin in obesity and insulin resistance seem paradoxical, since adipose tissue is the only source of adiponectin, and reports on that subject are contradictory.17226110
Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingUse of the IDF definition, which requires central obesity, is associated with greater insulin resistance but similar levels of other cardiovascular disease risk factors than the use of the AHA/NHLBI definition, which does not require central obesity.17228055
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe IDF definition may be more appropriate for the identification of those with insulin resistance and increased risk of type 2 diabetes.17228055
Glucose Intolerance (disease), Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe incidence of hypertension, glucose intolerance, insulin resistance and dyslipidemia was lower compared with obese women.17228087
ETV3 wt Allele, ObesityDeregulated Nutrient SensingAlthough they are not sufficient to support the hypothesis of differences in the underlying pathophysiological processes between these groups, our results illustrate the difficulty of using a single unifying definition of MetS, and suggest that different benefits may be obtained from treatments targeting obesity, blood pressure or insulin resistance.17229178
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingDyslipidemia [low high-density lipoprotein (HDL)-cholesterol] and impaired fasting glucose were more prevalent among the Brazilians, and increased blood pressure and abdominal obesity (in men) among the Italians.17229178
Diabetes MellitusDeregulated Nutrient SensingThiazolidinediones (TZD) may improve insulin resistance in patients with diabetes and HIV.17235334
Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingRisk factors for coronary artery disease (hypertension, diabetes mellitus, dyslipidemia, smoking, and obesity) were obtained from medical records to identify possible simultaneous risk factors for coronary artery disease.17236987
Increased insulin level, Liver CirrhosisDeregulated Nutrient SensingInsulin resistance in liver cirrhosis was higher than the other type 2 DM, and impaired hepatic insulin degradation might be an important mechanism of hyperinsulinemia in liver cirrhosis.17237630
Rheumatoid ArthritisDeregulated Nutrient SensingImpact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis.17237906
DyslipidemiasDeregulated Nutrient SensingIncreased insulin resistance and dyslipidemia were known risk factors in patients with active RA, however, the regulation of these metabolic parameters by TNF-alpha is poorly understood.17237906
Hypertensive (finding), diabeticDeregulated Nutrient SensingIn conclusion, Telmisartan improved insulin resistance with increased serum leptin level in hypertensive and type 2 diabetic patients.17240472
Diabetes MellitusDeregulated Nutrient SensingThree definitions were applied: National Cholesterol Education Program (NCEP), European Group for the Study of Insulin Resistance (EGIR) and International Diabetes Federation (IDF) criteria.17241181
Prediabetes syndrome, PrehypertensionDeregulated Nutrient SensingSurrogate markers of insulin resistance in assessing individuals with new categories "prehypertension" and "prediabetes".17243912
Prediabetes syndrome, PrehypertensionDeregulated Nutrient SensingThere are few data on the impact of insulin resistance on the recently defined categories of prehypertension (PHT) and prediabetes (PDM).17243912
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn postmenopausal women, endogenous estradiol (E2) and free testosterone (T) have been positively associated with glucose intolerance and type 2 diabetes.17244779
DyslipidemiasDeregulated Nutrient SensingThere is a primary focus in cholesterol management on the elevated low-density lipoprotein cholesterol (LDL-C) component of dyslipidemia and a secondary focus on the other components of dyslipidemia, such as low high-density lipoprotein cholesterol (HDL-C), high triglycerides (TGs), and high non-HDL-C.17249907
DyslipidemiasDeregulated Nutrient SensingCombination therapy to treat dyslipidemia has become common in many patients; however, it can also increase the risk of serious adverse effects.17253923
Glucose Intolerance (disease), Structure of beta Cell of isletDeregulated Nutrient SensingPancreatic B-cell function decreases as glucose intolerance develops.17257277
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA 12-month randomized trial was conducted in 72 patients with type 2 diabetes, HbA1c>or=8%, blood pressure (BP)>130/80 mmHg and dyslipidemia.17258926
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingMetabolic syndrome increases the risk for type 2 diabetes and cardiovascular disease (CVD) and may be associated with insulin resistance.17259468
Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingMetabolic syndrome increased risk for diabetes regardless of insulin resistance.17259468
Metabolic Syndrome XDeregulated Nutrient SensingMetabolic syndrome by ATP III criteria may require insulin resistance to increase risk for CVD.17259468
Diabetes Mellitus, Non-Insulin-Dependent, Beta-Cell Function MeasurementDeregulated Nutrient SensingInsulin resistance and impaired beta-cell function are key elements in the pathogenesis of type 2 diabetes.17259491
Inflammation, Kidney Failure, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingBecause renal failure per se is associated with both increased levels of circulating peptides and marked insulin resistance, even in the absence of diabetes mellitus, we hypothesized that visfatin could be a factor linking inflammation, kidney disease, and insulin resistance in this patient group.17261426
Diabetes Mellitus, Non-Insulin-Dependent, Prostate Cancer Outcomes Study, Lipoatrophic Diabetes Mellitus, Polycystic Ovary SyndromeDeregulated Nutrient SensingWe examined the relationship between insulin resistance and vascular function in three insulin-resistant states (type 2 diabetes, non-HIV lipodystrophic diabetes, and nondiabetic polycystic ovary syndrome [PCOS]) and in healthy control subjects.17261751
physiopathologicalDeregulated Nutrient SensingInsulin resistance, free fatty acids, adiponectin, or C-reactive protein did not associate with vascular dysfunction.17261751
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAmong these different types of patients with insulin resistance, we found abnormal endothelium-dependent vasodilation only in the patients with type 2 diabetes.17261751
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe human acyl-CoA-binding protein (ACBP) is a potential candidate gene of type 2 diabetes (T2D), since it plays a central role in determining the intracellular concentration of activated fatty acids which contribute to insulin resistance.17262885
Diabetes MellitusDeregulated Nutrient SensingAfter adjustment for these factors, adiponectin was significantly inversely associated with insulin resistance, triglyceride, C-reactive protein (but not interleukin 6), tissue plasminogen activator and alanine aminotransferase and positively associated with high-density lipoprotein cholesterol (HDL-cholesterol) and Factor VIII, factors associated with diabetes.17264850
Inflammation, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and erythrocyte sedimentation rate (ESR, a non-specific marker of inflammation) are known risk factors for cardiovascular disease.17264953
ObesityDeregulated Nutrient SensingAlthough obesity is associated with increased ESR, it is unclear whether insulin resistance is associated with ESR in humans.17264953
ObesityDeregulated Nutrient SensingIn conclusion, ESR is independently associated with either insulin resistance or obesity in a sex-specific manner.17264953
Tumor necrosis, Cardiac dysfunction, Dilated Cardiomyopathy PathwayDeregulated Nutrient SensingPatients with dilated cardiomyopathy possess insulin resistance independently of cardiac dysfunction or serum tumor necrosis factor-alpha.17268122
Doctor of Chiropractic, Dilated Cardiomyopathy Pathway, Congestive heart failureDeregulated Nutrient SensingIt has recently been reported that insulin resistance is prevalent in patients with dilated cardiomyopathy (DCM); however, it remains unclear whether insulin resistance is directly induced by DCM or if it is caused by congestive heart failure associated with DCM.17268122
Tumor necrosisDeregulated Nutrient SensingWe also measured the level of serum tumor necrosis factor (TNF)-alpha as a possible causative factor for inducing insulin resistance.17268122
Doctor of Chiropractic, Cardiac dysfunctionDeregulated Nutrient SensingIn conclusion, patients with DCM possess insulin resistance independently of the severity of cardiac dysfunction or serum TNF-alpha, suggesting that insulin resistance in patients with DCM may be closely associated with the pathogenic condition of DCM itself.17268122
ObesityDeregulated Nutrient SensingPatients with insulin resistance and obesity, who commonly have low HDL, may therefore benefit from addition of herring to the diet.17268414
Hypertensive disease, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIn spite of an overall similar prevalence of smoking, and a lower incidence of dyslipidemia and HTN, moderate CKD patients had a higher prevalence of Whitehall criteria abnormal ECG findings compared with the patients with DM.17269521
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingHigh frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.17272748
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBecause mitochondria play pivotal roles in both insulin secretion from the pancreatic beta cells and insulin resistance of skeletal muscles, we performed a large-scale association study to identify mitochondrial haplogroups that may confer resistance against or susceptibility to type 2 diabetes mellitus (T2DM).17273962
Lichen Planus, Demographics Domain, Diabetes Mellitus, diabeticDeregulated Nutrient SensingTo establish the prevalence of diabetes mellitus (DM) and insulin resistance in patients with lichen planus (LP), and to examine whether diabetic status showed any relation with the type of LP.17275122
Increased insulin levelDeregulated Nutrient SensingThis fact must be considered for the diagnosis of hyperinsulinism and insulin resistance in children.17277855
Prostate carcinomaDeregulated Nutrient SensingInsulin resistance is inversely related to prostate cancer: a prospective study in Northern Sweden.17278097
Prostate carcinomaDeregulated Nutrient SensingFactors related to insulin resistance have been implicated in prostate cancer development, however, few analytical studies support such an association.17278097
Prostate carcinoma, NeoplasmsDeregulated Nutrient SensingOur data suggest that androgens, which are inversely associated with insulin resistance, are important in the early prostate cancer development, whereas insulin resistance related factors may be important for tumour progression.17278097
Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingThe frequencies of other then hyperglycaemia risk factors were: arterial hypertension - 67%, obesity and overweight respectively 38% and 26%, smoking - 32%, dyslipidemia - 28%.17278782
Hyperleucinemia, Hypertensive (finding)Deregulated Nutrient SensingWe investigated the effect of a slow-release alpha1-receptor blocker, bunazosin hydrochloride, on leptin levels and insulin resistance in obese hypertensive patients with hyperleptinemia.17283868
Hyperleucinemia, Hypertensive (finding), ObesityDeregulated Nutrient SensingIn conclusion, bunazosin hydrochloride reduced the plasma leptin level and improved insulin resistance in hypertensive patients with obesity and hyperleptinemia.17283868
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow birth weight (LBW), a surrogate marker of an adverse fetal milieu, is linked to muscle insulin resistance, impaired insulin-stimulated glycolysis, and future risk of type 2 diabetes.17284623
OverweightDeregulated Nutrient SensingAlthough an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.17285123
diabeticDeregulated Nutrient Sensing(2) The frequency of C allele is significantly lower in type 2 diabetic patients with insulin resistance compare with those without insulin resistance (P is 0.0121).17285539
HyperglycemiaDeregulated Nutrient SensingIn contrast to other diseases occurring in the intensive care unit, hyperglycemia or insulin resistance plays no significant role.17286217
Fetal Growth RetardationDeregulated Nutrient SensingInsulin resistance has been linked to intrauterine growth retardation (IUGR); adiponectin is a protein with insulin-sensitizing properties.17287418
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSome authors suggest that increased serum resistin levels are associated with obesity, visceral fat, insulin resistance, type 2 diabetes and inflammation, while others failed to observe such correlations.17287419
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVariants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.17287471
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance.17287471
HyperhomocysteinemiaDeregulated Nutrient SensingFurthermore, multiple regression analysis showed that hyperhomocysteinemia was closely related to insulin resistance and visceral adiposity.17291621
Hyperhomocysteinemia, IAPP geneDeregulated Nutrient SensingOur results indicate that the presence of hyperhomocysteinemia in our population of Japanese patients with type 2 diabetes-associated insulin resistance was associated with increased visceral but not subcutaneous adiposity.17291621
Cardiac complication, Obesity, AtherosclerosisDeregulated Nutrient SensingInsulin resistance constitutes a pathophysiologic link between obesity, atherosclerosis, and/or cardiovascular complications.17292720
Diabetes MellitusDeregulated Nutrient SensingThe FABP2 Ala54Thr polymorphism has been associated with insulin resistance and diabetes in several populations.17292994
RestenosisDeregulated Nutrient SensingHemoglobin A1C, insulin, and insulin resistance at the time of the PCI are not associated with restenosis.17293264
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRetinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes.17299074
Diabetes MellitusDeregulated Nutrient SensingUnderstanding the relationship of these adipokines to insulin resistance may foster the development of new treatments for diabetes.17299074
Lipodystrophy, Pancreatitis, Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient Sensinglipodystrophy and early childhood diabetes with extreme insulin resistance and hypertriglyceridemia leading to recurrent pancreatitis, was assessed at an academic medical center.17299075
ObesityDeregulated Nutrient SensingThese lipid changes were associated with insulin resistance, a pathogonomic characteristic of acquired obesity in these young adult twins.17299598
Inflammation, ObesityDeregulated Nutrient SensingOur results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.17299598
OverweightDeregulated Nutrient SensingInsulin resistance and degree of overweight were associated with the MS.17301109
Increased insulin level, Carcinogenesis, Malignant neoplasm of endometrium, Diabetes MellitusDeregulated Nutrient SensingAlthough there is accumulating evidence that hyperinsulinemia in the context of insulin resistance is associated with carcinogenesis, only one prospective study of endometrial cancer incidence, in relation to diabetes, addressed this issue and showed no significant positive association.17301260
OverweightDeregulated Nutrient SensingSerum adiponectin and leptin levels and insulin resistance in children born large for gestational age are affected by the degree of overweight.17302868
ObesityDeregulated Nutrient SensingThe adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features.17302872
Diabetes MellitusDeregulated Nutrient SensingResistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents.17303077
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRosiglitazone and carotid IMT progression rate in a mixed cohort of patients with type 2 diabetes and the insulin resistance syndrome: main results from the Rosiglitazone Atherosclerosis Study.17305652
AtherosclerosisDeregulated Nutrient SensingInsulin resistance is associated with progression of atherosclerosis.17305652
Diabetes Mellitus, Non-Insulin-Dependent, Carotid Intima-Media ThicknessDeregulated Nutrient SensingWe assessed the effect of 12 months of treatment with rosiglitazone (RSG) on the progression of carotid intima-media thickness (IMT) in people with type 2 diabetes mellitus (T2DM) or the insulin resistance syndrome (IRS).17305652
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPhysical inactivity, low education, dyslipidemia, hypertension and diabetes were associated with CHD.17306273
HD Term Type, DyslipidemiasDeregulated Nutrient SensingAn elevated PLTP activity in HD patients may be considered as a further aspect of uremic dyslipidemia in HD patients.17308375
Demographics Domain, Dyslipidemias, Diabetes Mellitus, GYPB gene, Hyperuricemia, "Sjogrens SyndromeDeregulated Nutrient SensingTo analyze the prevalence and clinical significance of associated metabolic alterations [dyslipidemia, diabetes mellitus (DM), and hyperuricemia] in a large series of unselected patients with primary Sjogren's syndrome (SS).17309127
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingIn comparison with controls, patients with primary SS showed a higher frequency of dyslipidemia (47% vs 33%; p = 0.002), DM (28% vs 18%; p = 0.006), and hyperuricemia (9% vs 4%; p = 0.007).17309127
Dyslipidemias, Demographics Domain, HyperuricemiaDeregulated Nutrient SensingPatients with primary SS showed a higher prevalence of associated dyslipidemia, DM, and hyperuricemia in comparison with an age and sex-matched control group.17309127
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.17309383
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study was done to determine whether the supplement of Agaricus blazei Murill extract improves insulin resistance in type 2 diabetes.17309383
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSupplement of ABM extract improves insulin resistance among subjects with type 2 diabetes.17309383
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingManagement of dyslipidaemia in patients with type 2 diabetes in Australian primary care.17309401
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo examine the frequency of dyslipidaemia and treatment with lipid-lowering drugs in patients with type 2 diabetes managed in Australian primary care.17309401
Malignant neoplasm of liver, Glucose Intolerance (disease)Deregulated Nutrient SensingThis study implies that glucose intolerance may be an independent risk factor for liver cancer.17310595
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) has been consistently associated with obesity and insulin resistance.17311652
Fatty Liver DiseaseDeregulated Nutrient SensingSubjects with NASH had more severe insulin resistance when compared to those with simple fatty liver.17311652
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance is higher in subjects with NASH versus those with simple fatty liver.17311652
Hepatitis C, HIV InfectionsDeregulated Nutrient SensingHepatitis C virus infection is associated with insulin resistance among older adults with or at risk of HIV infection.17314526
Communicable Diseases, Hepatitis C, HIV InfectionsDeregulated Nutrient SensingTo determine the associations of hepatitis C virus (HCV) infection with insulin resistance and abnormal glucose tolerance in a cohort of older adults with or at risk of HIV infection.17314526
Weight Gain, Autoimmune Diseases, Demographics Domain, Kidney FailureDeregulated Nutrient SensingImportant in this connection is the so-called 'accelerator hypothesis', which postulates a common basis for both type-I and type-2 DM with genetic predisposition, insulin resistance (caused by rapid weight gain) and autoimmunity, leading to beta-cell insufficiency, as 'accelerators'.17315492
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingDiabetes and atherosclerosis are burgeoning health problems complicating obesity-associated insulin resistance (IR).17316097
Cushing Syndrome, Polycystic Ovary Syndrome, Adrenal Cortical AdenomaDeregulated Nutrient SensingUnilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome.17318025
HyperandrogenismDeregulated Nutrient SensingClinical signs of insulin resistance are often present: acanthosis nigricans, signs of hyperandrogenism.17320032
Lipodystrophy, Pancreatitis, Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient SensingAll lipodystrophies are associated with dysmetabolic alterations with insulin resistance, altered glucose tolerance or diabetes and hypertriglyceridemia leading to a risk of acute pancreatitis.17320032
Diabetes MellitusDeregulated Nutrient SensingThe association between leptin and incident diabetes is mediated by insulin resistance.17322479
Obesity, Diabetes MellitusDeregulated Nutrient SensingBy contrast, the positive association between IL-6 and diabetes appeared to be independent of obesity and insulin resistance.17322479
Tumor necrosis, ObesityDeregulated Nutrient SensingTumour necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine which has been closely linked to obesity and insulin resistance.17322487
Refractory anemias, SimultaneousDeregulated Nutrient SensingThis finding may implicate that TNFalpha blockade causes better glycaemic control in RA patients with concomitant diabetes, possibly by improving insulin resistance.17322487
Sleep Apnea Syndromes, Acromegaly, Hypertension, CTCAEDeregulated Nutrient SensingSleep apnoea syndrome (SAS) is common in acromegaly and both diseases are independently associated with hypertension and insulin resistance contributing to increased morbidity and mortality.17322492
Diabetes MellitusDeregulated Nutrient SensingTen patients had a homeostasis assessment model score > or = 4 indicating insulin resistance and one had diabetes mellitus requiring insulin.17322492
Hypertension, CTCAEDeregulated Nutrient SensingImportantly, a marked reduction of GH excess by transsphenoidal adenomectomy may cure SAS and improve insulin resistance and hypertension.17322492
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe tested the extent to which altered plasma adipokine levels may contribute to the increased carotid artery intima-media thickness (IMT) associated with type 2 diabetes mellitus and with male gender, independently of conventional cardiovascular risk factors, insulin resistance, and plasma C-reactive protein (CRP).17322499
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingPeroxisome proliferator-activated receptor (PPAR)-gamma, a member of the nuclear hormone receptor family, which is involved in the differentiation of adipose tissue, is reported to be associated with the pathogenesis of type 2 diabetes mellitus, insulin resistance and atherosclerosis.17322631
Androgenetic AlopeciaDeregulated Nutrient SensingThe presence of insulin resistance and comparison of various insulin sensivity indices in women with androgenetic alopecia.17324822
Dyslipidemias, Failure (biologic function)Deregulated Nutrient SensingFailure to be at goal was common even among those with previously diagnosed dyslipidemia (159/527, 30%) and those taking lipid-lowering agents (LLA) (71/370, 19%).17325272
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingMany patients hospitalized with ischemic stroke/TIA, including those with known dyslipidemia and those taking lipid lowering agents, have measured low-density lipoprotein (LDL) that is higher than recommended by national guidelines.17325272
Coronary Artery DiseaseDeregulated Nutrient SensingDual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease.17327326
Coronary Artery DiseaseDeregulated Nutrient SensingDual ET(A)+ET(B) receptor blockade acutely enhances insulin sensitivity in patients with insulin resistance and coronary artery disease, indicating an important role for endogenous ET-1.17327326
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHere, we investigated POPs and insulin resistance, a frequent pathogenic precursor of type 2 diabetes.17327331
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes MellitusDeregulated Nutrient SensingThese findings, coupled with those concerning diabetes prevalence, suggest that OC pesticides and nondioxin-like PCBs may be associated with type 2 diabetes risk by increasing insulin resistance, and POPs may interact with obesity to increase the risk of type 2 diabetes.17327331
Lipodystrophy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAnalysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes.17327441
LipodystrophyDeregulated Nutrient SensingIn summary, although heterozygous loss-of- function mutations in AKT2 can cause a syndrome of severe insulin resistance and lipodystrophy in humans, such mutations are uncommon causes of these syndromes.17327441
Lipodystrophy, Diabetes MellitusDeregulated Nutrient SensingMutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes.17327460
Obesity, Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance has been found to increase the risk of NASH, and obesity, and decreased levels of adiponectin are important factors in determining the severity of insulin resistance.17331160
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingTen percent, 26% and 73% of people with hyperglycemia, hypertension and dyslipidemia, respectively, were not on medications.17331807
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMost patients treated with either insulin or oral antidiabetic agents were on monotherapy as were those treated for hypertension and dyslipidemia.17331807
HyperandrogenismDeregulated Nutrient SensingThese findings are relevant to understanding the pathogenesis of insulin resistance in hyperandrogenic women.17332526
TG gene, DyslipidemiasDeregulated Nutrient SensingAmong women, TC and TG were strongly associated with age, body mass index (BMI) and family history of dyslipidemia.17333747
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingMore emphasis should be placed on understanding the epidemiology of hypercholesterolemia and other dyslipidemias in Thai men and women.17333747
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingOther variables commonly associated with type 2 diabetes, such as elevated BMI, hypertension or dyslipidaemia, did not independently contribute to the variance in hippocampal volume.17334649
Mucoepidermoid CarcinomaDeregulated Nutrient SensingMECT1, TORC1, or WAMTP1) to the Notch coactivator MAML2 is a characteristic feature of low-grade mucoepidermoid carcinomas of salivary and bronchial glands.17334997
Dyslipidemias, diabeticDeregulated Nutrient SensingLow HDL-cholesterol is common in European Type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan-European survey.17335463
Dyslipidemias, diabeticDeregulated Nutrient SensingTo measure the prevalence of low high-density lipoprotein (HDL)-cholesterol (men < 1.03 mmol/l; women < 1.29 mmol/l) in European Type 2 diabetic patients receiving treatment for dyslipidaemia.17335463
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe pan-European Survey of HDL-cholesterol measured lipids and other cardiovascular risk factors in 3866 patients with Type 2 diabetes and 4436 non-diabetic patients undergoing treatment for dyslipidaemia in 11 European countries.17335463
ETV3 wt AlleleDeregulated Nutrient SensingAlso endothelium-independent vasodilation (EIDV) induced by intra-brachial infusion of sodium nitroprusside was impaired in subjects with MetS and in insulin resistance.17335830
Chronic Kidney Insufficiency, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingA potentially modifiable risk factor for cardiovascular disease in patients with mild chronic renal insufficiency is dyslipidemia.17336698
Liver CirrhosisDeregulated Nutrient SensingInsulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4.17337499
diabeticDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4) has been identified as a novel adipokine mediating systemic insulin resistance, and elevated serum RBP4 indicates overt or impending insulin resistance in lean, obese, and type 2 diabetic subjects.17337499
Chronic liver disease, Lymphoproliferative Disorder of the Skin, Liver CirrhosisDeregulated Nutrient SensingAs insulin resistance is present in nearly all patients with liver cirrhosis, we evaluated RBP4 in patients with chronic liver disease (CLD).17337499
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Liver CirrhosisDeregulated Nutrient SensingRBP4 appears, unlike in obesity or type 2 diabetes, not to be a relevant systemic factor in the pathogenesis of insulin resistance in liver cirrhosis.17337499
diabeticDeregulated Nutrient SensingInsulin supplementation in diabetic subjects with CFTR deltaF508 mutation seems a rational therapy for consideration, although this does not preclude that therapy directed toward insulin resistance could also interact.17337503
CrexDeregulated Nutrient SensingParticipants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05).17341128
DyslipidemiasDeregulated Nutrient SensingAmong the type 2 diabetics, 68.8% had high blood pressure, and 98.2% had dyslipidemia.17341330
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe average number of medications that the patients were taking to treat type 2 diabetes was 1.3; to treat high blood pressure, 1.9; and to treat dyslipidemia, 0.6.17341330
Dyslipidemias, Retinal Diseases, Kidney DiseasesDeregulated Nutrient SensingAmong the study population in Medellin, the three chronic complications with the greatest impact on prognosis and health care costs of the diabetics were nephropathy, retinopathy, and dyslipidemia.17341330
DyslipidemiasDeregulated Nutrient SensingSerum lipid levels of the two groups were all close to the proper scopes of Principles for the prevention of dyslipidemia recommended by dyslipemia group of the editorial board of Chinese Journal of Cardiology.17343187
Infertility, Prostate Cancer Outcomes Study, Hirsutism, Weight decreased, Polycystic Ovary SyndromeDeregulated Nutrient SensingInsulin resistance, infertility, and hirsutism, common characteristics of polycystic ovary syndrome (PCOS), improve with even modest weight loss.17344488
Hypertension, CTCAE, Myocardial Ischemia, DyslipidemiasDeregulated Nutrient SensingHypertension, ischemic heart disease and dyslipidemia were found in 59.4%, 18.9% and 11.3% respectively.17344774
Breast CarcinomaDeregulated Nutrient SensingAccumulating evidence suggests that energy regulation, particularly insulin resistance, may influence breast cancer risk.17348446
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt has been suggested that Japanese subjects categorized as having normal weight (body mass index [BMI]<25.0) as defined by WHO (2000) have a tendency toward increased incidence of dyslipidemia and diabetes.17350486
Hepatobiliary Disorder, DyslipidemiasDeregulated Nutrient SensingAlthough we did not determine the cutoffs of the upper normal limits for AST, ALT, and GGT levels, we would suggest screening asymptomatic patients with dyslipidemia and also subjects with a family history of liver disease.17352018
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingAmong components of MS, serum GGT may be more associated with dyslipidemia and abnormal glucose tolerance, suggesting that serum GGT has more relationship with hepatic insulin resistance regardless of non-alcoholic fatty liver disease.17353063
ObesityDeregulated Nutrient SensingAssociation between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians.17353152
ObesityDeregulated Nutrient SensingAnthropometric markers of obesity are simple means that may be used as markers of cardiovascular risk and insulin resistance.17353152
Lupus ErythematosusDeregulated Nutrient SensingType B insulin resistance syndrome associated with systemic lupus erythematosus.17360301
Lupus ErythematosusDeregulated Nutrient SensingTo document a case of type B insulin resistance syndrome associated with systemic lupus erythematosus.17360301
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingOf these, some require glucose intolerance and others require obesity for the diagnosis.17363755
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn a previous study, regular aerobic physical activity in overweight/obese patients with type 2 diabetes mellitus was found to have significant beneficial effects on glycemic control, insulin resistance, cardiovascular risk factors, and oxidative stress.17365936
Microalbuminuria, diabeticDeregulated Nutrient SensingThe prevalence of microalbuminuria tended to decrease after six months of aerobic exercise in type 2 diabetic patients, independently of any improvement in insulin resistance and oxidative stress parameters.17365936
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingEffects of rosuvastatin on lipids, lipoproteins and apolipoproteins in the dyslipidaemia of diabetes.17367312
HyperhomocysteinemiaDeregulated Nutrient SensingThe present study was undertaken to evaluate the impact of impaired fasting glucose (IFG), insulin resistance (IR) and hyperhomocysteinaemia (Hhcy) on cognitive function (CF) in a sample of non-diabetic elderly subjects.17367706
Obesity, Diabetes MellitusDeregulated Nutrient SensingWestern style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance.17372899
AtherosclerosisDeregulated Nutrient SensingModulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis.17374708
Fever, CTCAEDeregulated Nutrient SensingLPS induced fever, blood, and adipose TNF and IL-6 and increased homeostasis model assessment of insulin resistance.17374708
Hypertension, CTCAE, Depression, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLogistic regression was used to adjust for factors that might be associated with switching (dose, age and the presence of hypertension, dyslipidaemia, diabetes or depression).17378846
Endothelial dysfunctionDeregulated Nutrient SensingInsulin resistance may be linked to endothelial dysfunction by several mechanisms, including disturbances in signaling pathways common to both insulin action and NO production.17379002
Endothelial dysfunctionDeregulated Nutrient SensingAsymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, may contribute to endothelial dysfunction, and elevated ADMA levels have been associated with both insulin levels and the degree of insulin resistance.17379002
Abnormal gastric motilityDeregulated Nutrient SensingIn a gastric emptying test by external ultrasonography, gastric emptying activity was significantly decreased in subjects with a high HOMA-R. We conclude that insulin resistance induces abnormal gastric motility.17380029
Abnormal gastric motilityDeregulated Nutrient SensingThough abnormal gastric motility is related to HOMA-R, the findings herein suggest that incretin, showing insulin resistance, or an adipocyokine might be related to the differences in EGG in both groups.17380029
Dyslipidemias, diabeticDeregulated Nutrient SensingAssociation between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia.17380302
Hyperlipidemia, Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingThioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic dyslipidaemia, since TXNIP is the strongest glucose-responsive gene in pancreatic B-cells, TXNIP deficiency in a mouse model is associated with hyperlipidaemia and TXNIP is located in the 1q21-1q23 chromosomal Type 2 diabetes mellitus (DM) locus.17381501
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingAlthough documented traditional cardiovascular risk factors (hypertension, diabetes, smoking, and dyslipidemia) increase the risk of developing coronary artery disease, their influence on the treatments and outcomes of patients with non-ST-segment elevation myocardial infarction (NSTEMI) has not been fully elucidated.17383286
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance is associated with increased risk of major cardiovascular events in patients with preexisting coronary artery disease.17383294
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance per se is an independent risk factor for cardiovascular events and new diabetes in patients with preexisting coronary artery disease.17383294
AtherosclerosisDeregulated Nutrient SensingAdipocyte hormones, resistin and adiponectin are implicated in insulin resistance and atherosclerosis.17383891
Chronic Kidney DiseasesDeregulated Nutrient SensingSubjects with CKD have increased insulin levels and insulin resistance index (IRI).17383891
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe insulin secretion/insulin resistance index is useful as a predictor of future development of type 2 diabetes.17384342
ObesityDeregulated Nutrient SensingCentral obesity is associated with insulin resistance through factors that are not fully understood.17384344
ObesityDeregulated Nutrient SensingResistin is derived from fat tissue in rodents, and serum levels are elevated in animal models of obesity and insulin resistance.17384443
Blood Clot, DyslipidemiasDeregulated Nutrient SensingThe child had been on dialysis, calcitriol, calcium carbonate, and presented dyslipidemia and calcified thrombi in various vessels and organs in the course of his condition.17384823
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOnly 64.7% of the respondents reported that they seek to determine the presence of diabetes mellitus, and 56.4% check for dyslipidemia.17384840
diabeticDeregulated Nutrient SensingThe insulin resistance index progressively increased when the glucose tolerance stage changed from NGT through diabetic subjects.17385686
ObesityDeregulated Nutrient SensingObesity and insulin resistance are the predominant features in the deterioration of glucose tolerance in Thais.17385686
Hypertensive (finding)Deregulated Nutrient SensingEvaluation of insulin resistance and sodium sensitivity in normotensive offspring of hypertensive individuals.17386322
Hypertension, CTCAEDeregulated Nutrient SensingSodium sensitivity (SS) and insulin resistance (IR) might be a common link in the pathogenesis of essential hypertension.17386322
Endothelial dysfunctionDeregulated Nutrient SensingEndothelial dysfunction is related to insulin resistance and inflammatory biomarker levels in obese prepubertal children.17389466
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe recent observations that Peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1A) is responsible for the induction of reactive oxygen species (ROS) detoxifying agents and that ROS triggers insulin resistance, support the role that this gene could play in the onset of Type 2 diabetes mellitus (T2DM).17390150
Diabetes MellitusDeregulated Nutrient SensingIGT, insulin resistance and type 2 diabetes are far more common in obese Turkish children than previously thought.17391156
Sandawe languageDeregulated Nutrient SensingSagittal abdominal diameter (SAD), a simple marker of intra-abdominal fat, predicts insulin resistance and cardiovascular mortality in men.17391519
Sandawe languageDeregulated Nutrient SensingOverall, SAD showed a slightly higher correlation with most cardiovascular risk factors, especially insulin resistance, insulin, CRP, apolipoprotein B and triglycerides (all P-values < 0.01) than other anthropometric measures.17391519
Sandawe languageDeregulated Nutrient SensingSAD explained a greater proportion of the variation of insulin resistance and CRP levels, even independently of the other anthropometric measures.17391519
Sandawe language, InflammationDeregulated Nutrient SensingSAD identifies insulin resistance, subclinical inflammation or raised serum lipids in a Swedish population with a large proportion of immigrant women from the Middle East.17391519
Cereals, Inflammation, Obesity, Diabetes MellitusDeregulated Nutrient SensingWhole grain intake and its cross-sectional association with obesity, insulin resistance, inflammation, diabetes and subclinical CVD: The MESA Study.17391554
Cereals, Inflammation, Obesity, Diabetes MellitusDeregulated Nutrient SensingConcordant with previous research, whole grain intake was inversely associated with obesity, insulin resistance, inflammation and elevated fasting glucose or newly diagnosed diabetes.17391554
HyperinsulinismDeregulated Nutrient SensingOur study shows that in severely obese, non-diabetic, hyperinsulinaemic patients undergoing a nutritional programme, rosiglitazone is more effective than metformin in producing favourable changes in fasting-based indexes of glucose metabolism, with a reduction of both insulin resistance and hyperinsulinaemia.17394563
Dyslipidemias, Atherosclerosis, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAtherosclerosis may also participate in a feed-forward cycle as aging, diabetes, dyslipidemia, and hypertension may also represent independent downstream consequences of global sympathetic bias.17400398
ObesityDeregulated Nutrient SensingsP-selectin plasma levels in obesity: association with insulin resistance and related metabolic and prothrombotic factors.17400434
Cardiovascular Diseases, Dyslipidemias, Hypothalamo-Hypophyseal System, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingCardiovascular disease, hypertension, dyslipidaemia and obesity in patients with hypothalamic-pituitary disease.17403957
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOf the 152 patients, 36.8% had treated hypertension and 28.2% had treated dyslipidaemia.17403957
ObesityDeregulated Nutrient SensingThe raising prevalence of obesity among children increases the risk of insulin resistance and its adverse metabolic consequences.17406738
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance.17408525
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAn increase in association in men with several cardiovascular risk factors (smoker, dyslipidemia and hypertension) was also observed.17409181
Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive (finding)Deregulated Nutrient SensingAlthough the prevalences of grades I and II HR were higher and grade 0 HR was lower in the hypertensive group, respectively (P < 0.001 for all), differences according to obesity, diabetes mellitus, hypertriglyceridemia (P < 0.001 for all), and dyslipidemia (P < 0.01) were also significant between the 2 groups.17409584
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIndependent correlates of in-hospital mortality were untreated dyslipidaemia, advanced age, diabetes, and low blood pressure.17412730
Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disordersDeregulated Nutrient SensingWe tested the hypothesis that increased abdominal visceral accumulation (VFA) is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients not receiving insulin treatment.17415564
Depressed mood, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results demonstrate that the level of VFA is associated with depressed cardiovascular autonomic function and insulin resistance in patients with type 2 diabetes mellitus.17415564
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia and associated factors among the hypertensive rural chinese population.17416291
Cessation of life, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia plays a crucial rule in the development of cardiovascular disease, which has become the leading cause of death in most developed countries as well as in developing countries.17416291
Hypertensive (finding), Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThis study demonstrated that the prevalence of dyslipidemia was relatively high among rural hypertensive patients in China and there were many modifiable risk factors for dyslipidemia such as hypertension, weight, and impaired glucose metabolism.17416291
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTo prevent dyslipidemia and to reduce the increasing burden of cardiovascular disease in rural areas with the undeveloped economy of China, the first aim for us is to reduce these risk factors.17416291
Adenoma of large intestineDeregulated Nutrient SensingInsulin resistance-related genes and advanced left-sided colorectal adenoma.17416760
Colorectal NeoplasmsDeregulated Nutrient SensingInsulin resistance has been linked with colorectal neoplasia through a number of mechanistic and observational studies.17416760
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance recently has been reported to play a major role in nonalcoholic fatty liver disease (NAFLD).17419265
Fatty LiverDeregulated Nutrient SensingWe evaluated the influence of fertility on fatty liver injury in fertile and postmenopausal women with insulin resistance.17419265
Nonalcoholic Steatohepatitis, Liver damage, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingWe demonstrate that fertility is an important factor in fatty liver damage of NAFLD with insulin resistance, suggesting that estrogen may exacerbate nonalcoholic steatohepatitis.17419265
Sleep-Disordered Breathing, Glucose Intolerance (disease), Obesity, Diabetes MellitusDeregulated Nutrient SensingTo determine the association between sleep-disordered breathing (SDB) and obesity, diabetes and glucose intolerance among middle-aged men and women in Finland.17419721
Sleep-Disordered Breathing, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAfter adjustments for age, body mass index, smoking and central nervous system-affecting medication, SDB was independently associated with diabetes and glucose intolerance in men, but not in women.17419721
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAmong individuals with T2DM, cortisol levels during the DEX/CRH test were positively associated with glycosylated hemoglobin (P = 0.05), independent of age, body mass index, hypertension, and dyslipidemia.17426095
AtherosclerosisDeregulated Nutrient SensingAlanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study.17429060
Hyperglycemia, Impaired T cell functionDeregulated Nutrient SensingET-1 is also a mediator that is elevated in conditions such as insulin resistance, hyperglycemia, oxidative stress, and endothelial cell dysfunction.17429733
Myocardial Contraction, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingHowever, diabetes, hypertension, dyslipidemia, myocardial infraction, and obesity have not had such effects.17433083
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe medical history concerning diabetes mellitus, arterial hypertension, dyslipidaemia, smoking and obesity was taken from every participant.17436151
Complications of Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim was to investigate the association between RBP4 and various markers related to insulin resistance and diabetic complications in type 2 diabetic patients.17440021
Complications of Diabetes MellitusDeregulated Nutrient SensingThe current study shows that RBP4 is associated with variables related to insulin resistance and diabetic complications.17440021
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus.17440034
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is typically more severe in obese individuals with type 2 diabetes (T2DM) than in similarly obese non-diabetics but whether there are group differences in body composition and whether such differences contribute to the more severe IR of T2DM is uncertain.17440034
Colorectal NeoplasmsDeregulated Nutrient SensingInsulinlike growth factor I receptor and estrogen receptor beta expressions are inversely correlated in colorectal neoplasms and affected by the insulin resistance syndrome.17442373
Colorectal CarcinomaDeregulated Nutrient SensingThe results suggest the combined effect of IGF-I and estrogens in colorectal cancer, with a distinctive role in individuals with the insulin resistance syndrome.17442373
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensinguPAR MFI Index was increased from 0.78 +/- 0.86 in control group to 1.91 +/- 1.97 and 3.33 +/- 2.52 in dyslipidemia group and hypertension + obesity group, respectively, P<0.05.17445414
Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidemia and obesity may contribute to the increase of uPAR expression.17445414
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur findings suggest that the -238G>A and -308G>A polymorphisms of TNF-alpha alter circulating free fatty acids and insulin resistance in obese subjects with type 2 diabetes mellitus.17445540
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLack of association of CPT1A polymorphisms or haplotypes on hepatic lipid content or insulin resistance in Japanese individuals with type 2 diabetes mellitus.17445541
Diabetes MellitusDeregulated Nutrient SensingAccumulation of fat in the liver is associated with insulin resistance and type 2 diabetes mellitus.17445541
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe have now investigated the contribution of the CPT1A locus to hepatic lipid content (HLC), insulin resistance, and susceptibility to type 2 diabetes mellitus.17445541
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNeither haplotypes nor SNPs of CPT1A were found to be associated either with susceptibility to type 2 diabetes mellitus or with HLC or insulin resistance in type 2 diabetic patients.17445541
Acanthosis NigricansDeregulated Nutrient SensingRegression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndrome.17445543
HypoglycemiaDeregulated Nutrient SensingAutoantibodies directed against specific epitopes in the insulin receptor are rarely the cause of either recurrent hypoglycemia or a severe form of insulin resistance (type B insulin resistance).17445543
Autoimmune DiseasesDeregulated Nutrient SensingType B insulin resistance occurs more commonly in women of African heritage and is frequently associated with a history of other autoimmune diseases.17445543
Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNT-pro-BNP remained predictive of total and cardiovascular mortality after accounting for age, sex, diabetes mellitus, body mass index, smoking, hypertension, dyslipidemia, glomerular filtration rate, presence or absence of CAD on angiography, cardiovascular medication, revascularization at baseline, clinical signs of heart failure, LV systolic function, and C-reactive protein.17446333
Obesity, AbdominalDeregulated Nutrient SensingShort stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceio, north-eastern Brazil.17446818
Obesity, AbdominalDeregulated Nutrient SensingTo test the hypothesis that short stature is associated with abdominal obesity, insulin resistance and lipid profile changes.17446818
OverweightDeregulated Nutrient SensingShort stature, when associated with overweight, is a risk factor for increased insulin resistance and alterations in lipid profile.17446818
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance as predictor of the angiographic severity and extent of coronary artery disease.17453676
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance (IR) is frequently observed in patients with coronary artery disease (CAD).17453676
Microalbuminuria, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingEighty-two patients with T2DM without symptoms of CAD, and with >or=1 CV risk factor (hypertension, dyslipidaemia, premature familial CAD, smoking or microalbuminuria) underwent a diagnostic stress test and coronary angiography irrespective of stress test results.17454845
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe HIV cohort had significantly higher proportions of hypertension (21.2 vs. 15.9%), diabetes (11.5 vs. 6.6%), and dyslipidemia (23.3 vs. 17.6%) than the non-HIV cohort (P < 0.0001 for each comparison).17456578
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingAdiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease.17457380
Iron-Refractory Iron Deficiency Anemia, Glucose Intolerance (disease), Hypertension, CTCAE, Retinal DiseasesDeregulated Nutrient SensingHe was known for arterial hypertension (risk factor), mild microcytic anaemia and mild glucose intolerance, which may be responsible for some unusual features of the retinopathy.17458812
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObese type 2 diabetes is recently increasing in Korea, indicating a shift from insulin secretory defects to insulin resistance.17459510
Diabetes MellitusDeregulated Nutrient SensingComparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes.17460368
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, pioglitazone was superior to metformin for the improvement of insulin resistance and adiponectin, and both drugs were equally effective in reducing vWF and aldosterone in subjects with IGT and early diabetes.17460368
Antihypertensive AgentsDeregulated Nutrient SensingIn conclusion, in contrast with the reports that telmisartan may decrease insulin resistance by an effect associated with its molecular structure, 8 weeks of telmisartan treatment in the present study had a neutral effect on insulin resistance in hypertensive MetS patients, and similar results were obtained for losartan.17460371
Hypertension, CTCAE, Ventricular hypertrophyDeregulated Nutrient SensingHigh-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension.17460382
Diabetic Nephropathy, Dyslipidemias, Kidney Failure, ChronicDeregulated Nutrient SensingThe remarkably high level of apoB48 in diabetic ESRD seems to be attributable to dyslipidemia induced by both diabetic nephropathy and ESRD.17462654
Diabetes MellitusDeregulated Nutrient SensingFurther, we propose that CA activity is a good candidate for a biomarker of diabetes mellitus for the early detection of insulin resistance because the CA activity variation was proportional to the severity of the diabetes.17464559
Cardiac dysfunction, MyocardiumDeregulated Nutrient SensingInsulin resistance is associated with various cardiac dysfunctions both molecularly and clinically, including cardiac muscle relaxation and blood flow.17467109
Heart failureDeregulated Nutrient SensingAlthough, these dysfunctions result in heart failure, relationship between insulin resistance and severity of heart failure is not well studied yet.17467109
Chronic heart failureDeregulated Nutrient SensingInsulin resistance seems to be one of the important targets in managing the chronic heart failure.17467109
diabeticDeregulated Nutrient SensingFurthermore, there is evidence to suggest that testosterone replacement therapy reduces insulin resistance and visceral adiposity in type 2 diabetic men.17468196
Kidney Failure, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance may contribute to cardiovascular disease and the progression of renal insufficiency in patients with chronic kidney disease (CKD).17468355
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Systolic hypertension, Coronary heart disease, Diabetes Mellitus, Cerebrovascular accident, Heart failure, Depression, CTCAE, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingObesity and depression are two major diseases which are associated with many other health problems such as hypertension, dyslipidemia, diabetes mellitus, coronary heart disease, stroke, myocardial infarction, heart failure in patients with systolic hypertension, low bone mineral density and increased mortality.17470289
Obesity, Abdominal, Cardiovascular Diseases, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingLow testosterone correlates with such risk factors of cardiovascular diseases as dyslipidemia, atherosclerosis, low fibrinolysis, insulin resistance and abdominal obesity.17472002
Glucose Intolerance (disease), AtherosclerosisDeregulated Nutrient SensingGlucose intolerance and insulin resistance/hyperinsulinemia are thought to influence the progression of atherosclerosis.17473485
Glucose Intolerance (disease)Deregulated Nutrient SensingRecently, the frequency of patients who have glucose intolerance has been increasing in Japan.17473485
Glucose Intolerance (disease), Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe rate of glucose intolerance and the levels of post-prandial glucose and insulin were high in the CHD group.17473485
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGlucagon plays an important role in postprandial hyperglycemia in type 2 diabetes (T2DM), and coexists with insulin resistance and impaired fibrinolysis.17473573
Nonalcoholic Steatohepatitis, Dyslipidemias, Liver Cirrhosis, Williams SyndromeDeregulated Nutrient SensingO verproduction of types I and III collagen and nonalcoholic steatohepatitis secondary to insulin resistance and dyslipidemia possibly contribute to cirrhosis in WS.17476199
Rheumatoid ArthritisDeregulated Nutrient SensingInsulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy.17476613
Refractory anemiasDeregulated Nutrient SensingPatients with RA had marked insulin resistance (glucose infusion rate (GIR) area under the curve (AUC) was 499+/-55 mg/kg in the RA group compared to 710+/-77 mg/kg in the control group; p<0.05).17476613
Refractory anemias, Inflammation, Disease remissionDeregulated Nutrient SensingRA patients with active disease showed marked insulin resistance that was not influenced by anti-TNFalpha therapy despite a reduction in systemic inflammation during the treatment.17476613
Glucose Intolerance (disease), GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingMoreover, glucose intolerance prevalence is lower in the follow-up after the ACS episode.17478004
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingFifty percent of patients were men, 32% were diabetic, 70% had hypertension, and 58% had dyslipidemia.17478140
Hyperglycemia, Dyslipidemias, diabetic, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingAs elderly diabetic patients are usually polymorbid, diabetes mellitus in old age is needed a more comprehensive approach to not only the treatment of hyperglycemia but also of hypertension, dyslipidemia and other associated diseases.17481770
ObesityDeregulated Nutrient SensingRegular alcohol consumption improves insulin resistance in healthy Japanese men independent of obesity.17482151
AutosomeDeregulated Nutrient SensingA mutation in the gamma2 subunit of the AMP activated protein kinase gene (PRKAG2) was identified in the four members of the family, with an autosomal dominant inheritance.17483151
Hyperlipidemia, Partial lipodystrophy, Dyslipidemias, USF1 wt Allele, Diabetes Mellitus, Non-Insulin-Dependent, DiseaseDeregulated Nutrient SensingInterestingly, the gene for CRABP-II is located on chromosome 1q21-23, which is a region that has been linked with disorders such as familial combined hyperlipidemia (FCHL), type 2 diabetes mellitus, and partial lipodystrophy, all of which are characterized by dyslipidemia.17484622
Peripheral Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingThe type of dyslipidemia in patients with peripheral arterial disease (PAD) is still ill defined.17485096
TG gene, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone hydrochloride produced beneficial effects on dyslipidemia in patients with type 2 diabetes, compared with the baseline and the glibenclamide group, as demonstrated by increases in high-density lipoprotein cholesterol (HDL-C) levels and low-density lipoprotein cholesterol (LDL) particle size, a fall in TG levels, and an increased ratio of visceral to subcutaneous fat volumes (V/S).17485893
Glucose Intolerance (disease), Prostate carcinomaDeregulated Nutrient SensingGlucose intolerance during hormonal therapy for prostate cancer.17486109
Glucose Intolerance (disease), Haiti, Structure of posterior cerebral arteryDeregulated Nutrient SensingTherefore, glucose intolerance should be considered during HT for PCa.17486109
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPreventing cardiovascular disease among Canadians: what are the potential benefits of treating hypertension or dyslipidemia?17487292
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTreatments for hypertension and dyslipidemia to prevent the development of cardiovascular disease compete for the same finite number of health care dollars.17487292
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTreating dyslipidemia was associated with an average increased life expectancy of 1.67 years and 1.81 years of life free of cardiovascular disease.17487292
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe potential benefits associated with treating hypertension or dyslipidemia to prevent cardiovascular disease are substantial.17487292
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHowever, compared with hypertension guidelines, dyslipidemia guidelines target higher-risk patients.17487292
Dyslipidemias, Peripheral Arterial DiseasesDeregulated Nutrient SensingDiagnosis and treatment of dyslipidemia are neglected in patients with peripheral artery disease.17487761
Communicable Diseases, Hypocortisolism secondary to another disorderDeregulated Nutrient SensingInsulin resistance declined with adrenal suppression and infection control, and wound healing improved dramatically.17490929
InfectionDeregulated Nutrient SensingIn our patient, substantially increased glucocorticoid levels were associated with severe insulin resistance, retarded wound healing, and persistent infections.17490929
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIncreased BMI was associated with increased prevalence of diabetes mellitus, hypertension and dyslipidaemia in both studies (p<0.001).17493087
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn both studies, prevalence of diabetes mellitus, hypertension and dyslipidaemia occurred across all ranges of BMI, but increased with higher BMI.17493087
One Vessel Coronary Disease, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Hypertensive (finding)Deregulated Nutrient SensingThe men had severe coronary disease with 69% having a prior myocardial infarction, 90% prior coronary artery bypass graft or percutaneous coronary intervention, 49% with three vessel coronary artery disease, 86% were not candidates for further revascularisation, 71% hypertensive, 83% dyslipidaemia, 42% diabetes mellitus, 75% smoking and 68% using nitrates.17493089
Acute Coronary Syndrome, DyslipidemiasDeregulated Nutrient SensingImplication of the new low-density lipoprotein goals in dyslipidemia management of patients with acute coronary syndrome.17493419
Dyslipidemias, Heart failure, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingCurrent evidence supports statin use in individuals with recognized heart failure and concomitant coronary heart disease, dyslipidemia, or diabetes mellitus.17495255
Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is involved in glucose intolerance, type 2 diabetes mellitus and hypertension.17496462
In-Stent Restenosis IndicatorDeregulated Nutrient SensingRemnant-like lipoprotein particle level and insulin resistance are associated with in-stent restenosis in patients with stable angina.17496497
RestenosisDeregulated Nutrient SensingOur findings suggest that high serum remnant-like lipoprotein particles cholesterol level, and not insulin resistance may be an independent risk factor on in-stent restenosis in nondiabetic patients with stable angina.17496497
icodextrin, DyslipidemiasDeregulated Nutrient SensingNo significant difference in serum lipid parameters was found between groups A, B, and C. These results demonstrate the lack of the effect of amino acid or icodextrin-based peritoneal solutions on dyslipidemia of CAPD patients.17497445
Cancer-related fatigueDeregulated Nutrient SensingIt was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease.17497447
Fatty Liver Disease, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe components of MS (obesity, hypertension, and dyslipidaemia) are associated with the presence of NASH in patients with CH-B.17498244
millicurieDeregulated Nutrient SensingFurther prospective cohort studies that follow a normal cognitive group and MCI patients with and without insulin resistance are necessary.17502006
Prostate carcinomaDeregulated Nutrient SensingFurthermore, SIRT1 down-regulation by small interfering RNA or by pharmacological means increased the sensitivity of androgen-responsive genes to androgen stimulation, enhanced the sensitivity of prostate cancer cell proliferative responses to androgens, and decreased the sensitivity of prostate cancer cells to androgen antagonists.17505061
Prostate carcinomaDeregulated Nutrient SensingCollectively, these findings identify SIRT1 as a corepressor of AR and elucidate a new molecular pathway relevant to prostate cancer growth and approaches to therapy.17505061
DyslipidemiasDeregulated Nutrient SensingDyslipidemia was defined as two consecutive total cholesterol (TC) values above recommended levels.17507323
F11 gene, DyslipidemiasDeregulated Nutrient SensingWe found almost a sixfold higher risk of IS in patients with dyslipidaemia and high levels of FXI.17511793
F11 gene, DyslipidemiasDeregulated Nutrient SensingFurther studies should elucidate the role of FXI in IS and therapeutic approaches should become apparent for patients with dyslipidaemia and high-FXI plasma levels.17511793
Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and self-rated symptoms of depression in Swedish women with risk factors for diabetes: the Women's Health in the Lund Area study.17512316
Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingPrevious studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance.17512316
Obesity, Abdominal, Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, lifestyle factors such as physical inactivity and abdominal obesity, but not insulin resistance, seem to be related to self-rated symptoms of depression in women with risk factors for diabetes mellitus.17512316
Depression, CTCAEDeregulated Nutrient SensingThe relationship between insulin resistance and major depression needs to be further examined.17512316
ObesityDeregulated Nutrient SensingThe aim of this study is to examine when impairment of early-phase insulin secretion occurs and whether it can be related to increase in insulin resistance caused by obesity.17512320
Immature, DyslipidemiasDeregulated Nutrient SensingDominance of smoking and dyslipidemias that are the preventable risk factors in premature CHD patients is an important threat for our community health.17513205
ObesityDeregulated Nutrient SensingThe present study suggests that increasing rates of obesity among Inuit will have health consequences and that anthropometry is a useful tool to indirectly assess insulin resistance/sensitivity.17515252
AcromegalyDeregulated Nutrient SensingInsulin resistance and insulin secretion in non-diabetic acromegalic patients.17516294
Refractory anemias, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no significant difference between RA and non-RA subjects in the risk imparted with respect to the other CV risk factors (ie, family cardiac history, hypertension, dyslipidaemia, body mass index, or diabetes mellitus).17517756
DyslipidemiasDeregulated Nutrient SensingEffect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia.17519084
DyslipidemiasDeregulated Nutrient SensingTherefore, we evaluated the effect of ezetimibe (a selective cholesterol transport inhibitor) on the concentrations of lipoprotein subfractions in patients with primary dyslipidaemia.17519084
DyslipidemiasDeregulated Nutrient SensingPatients (n = 50) with primary dyslipidaemias were recruited.17519084
No metabolic abnormalitiesDeregulated Nutrient SensingMetabolic abnormalities related to insulin resistance are also uncommon in this condition.17523150
Weight decreased, ObesityDeregulated Nutrient SensingObesity, insulin resistance, and weight loss have been associated with changes in hypothalamic-pituitary-adrenal (HPA) axis.17526821
ARCN1 gene, InflammationDeregulated Nutrient SensingInsulin resistance and inflammation - A further systemic complication of COPD.17530505
InflammationDeregulated Nutrient SensingSystemic inflammation in other populations is a factor in atherogenesis and has been associated with insulin resistance.17530505
ARCN1 gene, InflammationDeregulated Nutrient SensingWe assessed the association between systemic inflammation and insulin resistance in non-hypoxaemic patients with COPD.17530505
Tumor necrosisDeregulated Nutrient SensingInsulin resistance was related to interleukin-6 (IL-6), r=0.276, p=0.039, and tumour necrosis factor alpha soluble receptor I, r=0.351, p=0.008.17530505
ARCN1 gene, InflammationDeregulated Nutrient SensingWe demonstrated greater insulin resistance in non-hypoxaemic patients with COPD compared with healthy subjects, which was related to systemic inflammation.17530505
Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Cerebrovascular accidentDeregulated Nutrient SensingAge, hypertension, dyslipidemia, and atrial fibrillation were independent risk factors for stroke in this cohort.17531924
Breast CarcinomaDeregulated Nutrient SensingRelation between insulin resistance and breast cancer among Chilean women.17531933
Breast CarcinomaDeregulated Nutrient SensingThe association between insulin resistance and breast cancer, however, remains largely unexplored.17531933
InflammationDeregulated Nutrient SensingSecondary outcomes included endothelial-independent glyceryl trinitrate-mediated dilatation (GTNMD), large-artery compliance (C1), and levels of lipids, lipoproteins, and oxidized low-density lipoprotein, as well as markers of insulin resistance and inflammation.17533020
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIn patients with advanced CKD, atorvastatin is associated with improvement in dyslipidemia and small-artery stiffness, but not endothelial function.17533020
DyslipidemiasDeregulated Nutrient SensingFor males various modifiable risk factors were associated with the presence of CAD, particularly DM and dyslipidemia.17533472
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe profound effect of telmisartan to lower cholesterol suggests a potential use in hypertensive patients with dyslipidemia.17533580
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingWe found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule.17535270
Glucose Intolerance (disease)Deregulated Nutrient SensingFasting blood glucose was higher in IR subjects ([means +/- SD] 94.1 +/- 8.1 vs. 87.9 +/- 8.2, P < 0.05), indicating a very mild glucose intolerance.17536070
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn models using patients without risk factors (hypertension, obesity, smoking or dyslipidaemia ) as a referent group and comparing them to patients with the risk factor and with ID/II, and with DD genotypes, all models (except for smoking) favoured an increasing trend of risk with patients having the risk factor and DD genotype at the highest risk in women.17537156
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingSimilar trends for hypertension and dyslipidaemia were also observed in men.17537156
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingIn genotype 1 CHC patients, insulin resistance played a significant role in the response to antiviral therapy.17540037
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingIn CHC patients insulin resistance strongly influences the response to antiviral treatment in patients infected with genotype 1.17540037
PrehypertensionDeregulated Nutrient SensingPrehypertension and insulin resistance in a nationally representative adult population.17541327
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Hypertensive disease, Hypertension, CTCAEDeregulated Nutrient SensingHypertension (HTN) and dyslipidemia are major risk factors for coronary heart disease (CHD).17541329
Increased insulin level, Chronic Kidney DiseasesDeregulated Nutrient SensingWe sought to determine the prevalence of hyperinsulinemia and insulin resistance in pediatric patients with chronic kidney disease (CKD) stages 2-4.17541791
Increased insulin level, Chronic Kidney DiseasesDeregulated Nutrient SensingWe conclude that hyperinsulinemia and insulin resistance are frequent in pediatric CKD.17541791
Atheroma, Obesity, AtherosclerosisDeregulated Nutrient SensingResistin, a novel adipokine linked to insulin resistance and obesity in rodents, which is derived mainly from macrophages and identified in atheromas in human, has been shown to play a potential role in atherosclerosis.17543176
Prostate carcinomaDeregulated Nutrient SensingInsulin resistance-related gene polymorphisms and risk of prostate cancer.17548707
Glucose Intolerance (disease), Hypertriglyceridemia, Dental PlaqueDeregulated Nutrient SensingThe following risk factors were significantly related in univariate logistic models: glucose intolerance and coronary calcified lesions (p = 0.001), and hypertriglycemia and non-calcified plaque lesions (p = 0.048).17548955
Glucose Intolerance (disease)Deregulated Nutrient SensingOur results suggest that glucose intolerance might be closely related to the presence of coronary calcified lesions among traditional CAD risk factors.17548955
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingPrepubertal girls with obesity or insulin resistance are also at risk to develop the full PCOS phenotype after puberty.17550211
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWith a mean of two risk factors, the overall incidence of comorbidities was hypertension in 37%, dyslipidaemia in 28%, diabetes in 26%, coronary artery disease in 18% and lower urinary tract symptoms in 46%.17552959
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThere are currently 1.85 million reproductive-aged women in the United States with diabetes or glucose intolerance.17554614
Atherosclerosis of renal artery, AtherosclerosisDeregulated Nutrient SensingWhole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study.17556684
AtherosclerosisDeregulated Nutrient SensingThis study evaluated 1178 participants in the Insulin Resistance Atherosclerosis Study.17556684
FBN2 wt AlleleDeregulated Nutrient SensingThe relation between whole-grain intake and CCA IMT remained significant after adjustment for mediating pathways (lipids, adiposity, and insulin resistance), nutrient constituents, and a principal components-derived healthy dietary pattern.17556684
Increased insulin levelDeregulated Nutrient SensingThe patient was diagnosed with severe GH deficiency with modest fasting hyperinsulinemia and insulin resistance and started on GH replacement therapy, an alpha-glucosidase inhibitor (acarbose) and a diet low in simple carbohydrates.17556873
Sleep Apnea, Obstructive, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes.17557769
Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingThe effects of continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) on insulin resistance are not clear.17557769
Diabetes Mellitus, Non-Insulin-Dependent, Osage languageDeregulated Nutrient SensingTherapeutic CPAP does not significantly improve measures of glycaemic control or insulin resistance in men with type 2 diabetes and OSA.17557769
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingA negative association between T and insulin resistance as well as impaired glucose intolerance has been demonstrated and in type 2 diabetic men TS improves metabolic parameters.17558968
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingAlthough non-alcoholic steatohepatitis (NASH) is generally considered a hepatic manifestation of insulin resistance, there are no reports showing the link of AGE to NASH.17559366
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results from a sample of Iranian type 2 diabetes cases and controls provide evidence that the 1484insG genotype of the PTPN1 gene may be associated with insulin resistance and other cardiovascular risk factors in non-diabetic male subjects.17560463
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSubjects with obesity and elevated fasting blood glucose are at high risk of developing type 2 diabetes which may be reduced by a dietary intervention leading to an improvement of insulin resistance.17562226
Hypertensive (finding), Dyslipidemias, ObesityDeregulated Nutrient SensingOverweight or obesity were present in 82.6% of patients, 97% were hypertensive and 92.6% presented dyslipidemia.17564559
DyslipidemiasDeregulated Nutrient SensingTo determine the efficacy and safety of adding ezetimibe to maximally tolerated lipid lowering therapy in patients with HIV dyslipidemia.17565701
Increased insulin level, ObesityDeregulated Nutrient SensingMCP-1 is likely to participate in obesity, hyperinsulinemia, and insulin resistance in POCS.17565837
Diabetes MellitusDeregulated Nutrient SensingPlasma retinol-binding protein 4 (RBP4) may be a new adipokine linked to obesity-induced insulin resistance and type 2 diabetes.17568782
Diabetes MellitusDeregulated Nutrient SensingTherefore, further studies evaluating RBP4 as a regulator of systemic insulin resistance and type 2 diabetes will need to take renal function into consideration.17568782
SLC16A1 wt AlleleDeregulated Nutrient SensingThe MCT group showed an across-time reduction in body weight and WC, an increase in serum C-peptide concentration, a reduction in homeostasis model assessment of insulin resistance, and a decrease in serum cholesterol concentration (P < .05, repeated measures).17570262
Polycystic Ovary SyndromeDeregulated Nutrient SensingEstimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome.17570263
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, metabolic disturbance, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) is an independent risk factor for cardiovascular disease and is a prevalent metabolic disturbance among women with polycystic ovary syndrome (PCOS).17570263
Degenerative polyarthritisDeregulated Nutrient SensingOral glucosamine in doses used to treat osteoarthritis worsens insulin resistance.17570985
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn animals, the compound is known to cause insulin resistance, the underlying abnormality in type 2 diabetes mellitus.17570985
Degenerative polyarthritisDeregulated Nutrient SensingInsulin resistance in humans taking oral glucosamine in doses used for osteoarthritis has not been studied.17570985
Degenerative polyarthritisDeregulated Nutrient SensingOur data indicate that persons with underlying poorer insulin sensitivity are at risk for worsening insulin resistance and vascular function with the use of glucosamine in doses used to treat osteoarthritis.17570985
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity.17571165
Muscle (organ)Deregulated Nutrient SensingInsulin resistance in these tissues was associated with reduced insulin-stimulated insulin receptor substrate 1- (IRS-1-) and IRS-2-associated PI3K activity in muscle and liver, respectively.17571165
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThere is a beneficial effect on the co-morbid conditions like hypertension and dyslipidemia.17571741
Increased insulin level, Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients.17575088
Increased insulin levelDeregulated Nutrient SensingThis study demonstrates a direct relationship between aldosterone, insulin resistance, and hyperinsulinemia in white subjects.17575088
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe Barriers to Insulin Treatment Questionnaire appears to be a reliable and valid measure of psychological insulin resistance in patients with type 2 diabetes.17575092
Acromegaly, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus is accompanied in some acromegalic patients with insulin resistance.17575366
Inflammation, Hypoadiponectinemia, Hypertriglyceridemia, AtherosclerosisDeregulated Nutrient SensingCurrent findings suggest that relative importance of hypertriglyceridemia and enhanced inflammation, rather than insulin resistance, as the downstream events of hypoadiponectinemia leading to atherosclerosis in the Japanese general population.17575367
Amyotrophic Lateral Sclerosis, "Alzheimers Disease", Nerve DegenerationDeregulated Nutrient SensingSIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.17581637
Amyotrophic Lateral Sclerosis, Neurotoxicity Syndromes, Data types - AddressDeregulated Nutrient SensingHere, we report that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults.17581637
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingIn cell-based models for AD/tauopathies and ALS, SIRT1 and resveratrol, a SIRT1-activating molecule, both promote neuronal survival.17581637
Nerve DegenerationDeregulated Nutrient SensingFurthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred significant protection against neurodegeneration.17581637
Neurodegenerative DisordersDeregulated Nutrient SensingThus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention.17581637
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMost studies of diet in glucose intolerance and type 2 diabetes have focused on intakes of fat, carbohydrate, fibre, fruits and vegetables.17583796
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingCounselling on lifestyle changes to address hypertension helps patients reduce risk factors such as smoking, high alcohol consumption, overweight, dyslipidemia, negative stress and physical inactivity.17584423
Diabetes MellitusDeregulated Nutrient SensingAssociation of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study.17586736
Diabetes MellitusDeregulated Nutrient SensingWe measured oxidative stress using the ratio of urine 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha) to creatinine and used age- and sex-adjusted regression models to test the association of oxidative stress with insulin resistance in individuals without diabetes and among subgroups at elevated risk of diabetes.17586736
Diabetes MellitusDeregulated Nutrient SensingSystemic oxidative stress is associated with insulin resistance in individuals at average or elevated risk of diabetes even after accounting for BMI.17586736
ArteriosclerosisDeregulated Nutrient SensingOur results did not confirm the influence of insulin resistance on the development of arterial sclerosis lesions.17587749
Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia and type 2 diabetes mellitus (T2DM) increase atherosclerotic coronary heart disease (CHD) risk.17588297
Hyperhomocysteinemia, Dyslipidemias, Ischemic stroke, HypothyroidismDeregulated Nutrient SensingSubclinical hypothyroidism, hyperhomocysteinemia and dyslipidemia: investigating links with ischemic stroke in Turkish patients.17588311
Glucose Intolerance (disease)Deregulated Nutrient SensingThe rate of glucose intolerance, morbidity and mortality were 24.1%, 24.8% and 13.6%, respectively.17589925
diabeticDeregulated Nutrient SensingIn muscle, resistance to insulin-mediated glucose uptake is thought to underlie the pre-Type 2 diabetic condition.17593244
ObesityDeregulated Nutrient SensingObesity and physical inactivity (silent epidemic) are the dominant causes of insulin resistance.17593634
Metabolic DiseasesDeregulated Nutrient SensingThus, precise insulin resistance measurement in individuals at risk for metabolic diseases would support clinical risk stratification.17595351
Labor (Childbirth)Deregulated Nutrient SensingHowever, the gold standard for measuring insulin resistance, the hyperinsulinemic clamp test, is too labor intensive to be performed in large clinical studies/settings.17595351
Chronic myocardial ischemia, Electrocardiogram: myocardial infarction (finding), DyslipidemiasDeregulated Nutrient SensingDyslipidemia worsens a prognosis in patients with chronic heart ischemic disease, who underwent myocardial infarction.17598652
ObesityDeregulated Nutrient SensingWhen adjusting for this influence, we found a nongenetic negative association between birth weight and glucose tolerance as well as insulin resistance that was partially independent of adult obesity.17598817
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingBirth weight is nongenetically associated with glucose intolerance in elderly twins, independent of adult obesity.17598817
Increased insulin levelDeregulated Nutrient SensingThe possibility that hyperinsulinemia and/or insulin resistance may directly increase haptoglobin levels has never been tested.17598972
Increased insulin levelDeregulated Nutrient SensingHigher haptoglobin serum levels seem to be a strong marker of hyperinsulinemia, independently of BMI, body fat distribution, insulin resistance and related parameters.17598972
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingFemale patients presenting with HS should prompt investigations for underlying PCOS and insulin resistance.17601419
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Clinically significant macular edemaDeregulated Nutrient SensingThe study involved 47 patients with type II diabetes mellitus and dyslipidemia, with CSME.17605275
Hypertensive (finding), Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTreatment patterns of hypertension and dyslipidaemia in hypertensive patients at higher and lower risk of cardiovascular disease in primary care in the United Kingdom.17611550
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingFew studies have investigated the presence of dyslipidaemia in hypertensive individuals.17611550
Hypertensive (finding), Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThis retrospective cohort study examined treatment patterns for hypertension and dyslipidaemia among hypertensive patients in UK primary care.17611550
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe analysed the prevalence of risk factors and the prevalence and incidence of treatment for hypertension, dyslipidaemia and for both conditions between January 1997 and December 2001.17611550
Demographics Domain, Arthropathy, Dyslipidemias, Diabetes Mellitus, Hypertensive diseaseDeregulated Nutrient SensingPresence of diabetes mellitus (DM); high blood pressure (HBP), dyslipidemia and arthropathy were assessed.17612378
Dyslipidemias, PathologyDeregulated Nutrient SensingAssociated pathologies were present in 80,8% of the studied women: 46,9% (n = 61) with dyslipidemia; 42,3% (n = 55) with HBP; 33,1% (n = 43) with arthropaties; and 16,2% (n = 21) with DM.17612378
Hypertensive disease, Dyslipidemias, OverweightDeregulated Nutrient SensingOverweight and obese I women showed a higher prevalence of dyslipidemia (56%) and (52%), respectively; while in Obese II and Obese III, 38,7% and 47,1% presented HBP respectively.17612378
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingThere was a positive correlation (Spearman) among DM, HBP and dyslipidemia (p < 0,05) with age; and significant correlation (Pearson, p < 0,05) between W/H ratio and DM.17612378
Hypertensive disease, Dyslipidemias, Pathology, ArthropathyDeregulated Nutrient SensingThere was a high prevalence of associated pathologies in the valued women, being the most frequent dyslipidemia, HBP and arthropathy, which are directly proportional with the age and the IC/C.17612378
Diabetes MellitusDeregulated Nutrient SensingRosiglitazone (RSG) has been reported to reduce blood pressure (BP) in patients with type-2 diabetes, but similar effects in non-diabetic people with insulin resistance is less clear.17612907
Type 2, Diabetic RetinopathyDeregulated Nutrient SensingA community-based study of the relationship between insulin resistance/beta-cell dysfunction and diabetic retinopathy among type II diabetics in Kinmen, Taiwan.17613850
Type 2, Diabetic Retinopathy, Beta-cell dysfunction, GDC Disease Response TerminologyDeregulated Nutrient SensingTo explore whether insulin resistance and beta-cell dysfunction are both related to diabetic retinopathy (DR) in type II diabetics by using a community-based study in Kinmen, Taiwan.17613850
GDC Disease Response Terminology, Beta-cell dysfunction, Diabetes MellitusDeregulated Nutrient SensingBased on the multiple logistic regression, DR was found to be strongly related to both baseline insulin resistance (IR) and beta-cell dysfunction regardless of duration of diabetes.17613850
Diabetic Retinopathy, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingInsulin resistance and beta-cell dysfunction are both associated with diabetic retinopathy in type II diabetes.17613850
Prostate Cancer Outcomes Study, Dyslipidemias, Obesity, Hypertension, CTCAE, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is commonly associated with insulin resistance, obesity, dyslipidemia and hypertension.17616856
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is an important modifiable risk factor for cardiovascular disease (CVD).17617298
DyslipidemiasDeregulated Nutrient SensingStudies suggest that dyslipidemia is underdiagnosed and undertreated in Canada.17617298
DyslipidemiasDeregulated Nutrient SensingPatients with dyslipidemia fell mostly into very-high-risk (45.7%) or low-risk (31.1 %) categories for CAD.17617298
Hypertension, CTCAE, Coronary Artery Disease, Prostate carcinoma, DyslipidemiasDeregulated Nutrient SensingCoronary artery disease, benign hypertension, and dyslipidemia reduced the odds of late-stage prostate cancer.17619718
Diabetic Nephropathy, DyslipidemiasDeregulated Nutrient SensingIn recent studies, apolipoprotein E (apo E) genetic polymorphism in association with dyslipidemia have been proposed as the one of the risk factors for the development of diabetic nephropathy.17624465
Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTherefore, we aimed for investigating the association among apo E genetic polymorphism, dyslipidemia and the development of diabetic nephropathy in type 2 diabetic patients.17624465
Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese data suggest that E4 carrier might be associated with the protection for the development of diabetic nephropathy in type 2 diabetic patients without respect to dyslipidemia.17624465
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance in a US population with background exposure to POPs.17624515
Sleep Apnea, Obstructive, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity is an important risk factor for obstructive sleep apnoea syndrome (OSAS), insulin resistance and cardiovascular disease.17626108
DyslipidemiasDeregulated Nutrient SensingAlthough tesaglitazar is no longer in clinical development, these data indicate that dual PPARalpha/gamma agonism may be a useful pharmacological approach to improve the atherogenic dyslipidaemia associated with insulin resistance.17631296
PsychiatricDeregulated Nutrient SensingIndividuals had evaluation of glucose tolerance, insulin resistance (insulin suppression test), lipid concentrations, and psychiatric status before and after switching to aripiprazole for 4 months.17632220
Sleep Apnea, ObstructiveDeregulated Nutrient Sensing[The research of the correlation of obstructive sleep apnea-hypopnea syndrome and insulin resistance].17634025
Sleep Apnea, ObstructiveDeregulated Nutrient SensingTo investigate whether obstructive sleep apnea-hypopnea syndrome (OSAHS) is relevant to insulin resistance (IR) and whether it is an independent factor of IR.17634025
ObesityDeregulated Nutrient SensingThe improvement in insulin resistance was independent of the improvement in obesity.17634702
Kidney Failure, ChronicDeregulated Nutrient SensingInsulin resistance is a predictor of cardiovascular mortality in patients with end-stage renal disease.17635748
Hyperinsulinism, Cardiovascular DiseasesDeregulated Nutrient SensingARB that ameliorate insulin resistance and hyperinsulinaemia could also provide effective options for preventing cardiovascular disease in patients with MHD.17635748
Obesity, AbdominalDeregulated Nutrient SensingAlcohol intake, insulin resistance, and abdominal obesity in elderly men.17636095
Obesity, Abdominal, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance, insulin secretion, and abdominal obesity are major predictors of diabetes, but the links with alcohol intake remain contradictory because of limited data.17636095
Prostate carcinomaDeregulated Nutrient SensingSIRT1 is significantly elevated in mouse and human prostate cancer.17638871
Primary malignant neoplasmDeregulated Nutrient SensingEvidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer.17638871
Primary malignant neoplasmDeregulated Nutrient SensingTo better understand the relationship among SIRT1, energy balance, and cancer, two experiments were done.17638871
Prostatic Neoplasms, NeoplasmsDeregulated Nutrient SensingSecond, immunohistochemistry was done on human prostate tumors to determine if SIRT1 was differentially expressed in tumor cells versus uninvolved cells.17638871
CarcinogenesisDeregulated Nutrient SensingResults show that SIRT1 is not increased in the dorsolateral prostate (DLP) of calorie-restricted mice during carcinogenesis.17638871
AdenocarcinomaDeregulated Nutrient SensingIn contrast, when examined in the DLP as a function of pathologic score, SIRT1 was significantly elevated in mice with poorly differentiated adenocarcinomas compared with those with less-advanced disease.17638871
Adenocarcinoma of prostate, NeoplasmsDeregulated Nutrient SensingHIC-1, which has been shown to regulate SIRT1 levels, was markedly reduced in the same tumors, suggesting that a reduction in HIC-1 may be in part responsible for the increased expression of SIRT1 in prostatic adenocarcinomas.17638871
Prostatic Neoplasms, Primary malignant neoplasmDeregulated Nutrient SensingFurthermore, immunostaining of human prostate tumors showed that cancer cells had greater SIRT1 expression than uninvolved cells.17638871
CarcinogenesisDeregulated Nutrient SensingIn conclusion, DLP SIRT1 expression from calorie-restricted mice was not altered during carcinogenesis.17638871
Adenocarcinoma, Prostate carcinomaDeregulated Nutrient SensingHowever, SIRT1 expression was increased in mice with poorly differentiated adenocarcinomas and in human prostate cancer cells.17638871
Prostate carcinoma, NeoplasmsDeregulated Nutrient SensingBecause SIRT1 may function as a tumor promoter, these results suggest that SIRT1 should be considered as a potential therapeutic target for prostate cancer.17638871
Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingThis study tested the hypothesis that RBP4 is a marker of insulin resistance and the metabolic syndrome in patients with type 2 diabetes or coronary artery disease (CAD) or in non-diabetic control subjects without CAD.17639305
Beta-Cell Function MeasurementDeregulated Nutrient SensingInsulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant.17642423
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPossible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes.17644622
diabeticDeregulated Nutrient SensingIn type 2 diabetic patients, both AUC(IRG) and AUC(CPR) increased with increasing BMI, basal CPR level, and homeostasis model assessment of insulin resistance value.17644622
deficiency aspects, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIntraislet insulin deficiency and alpha-cell insulin resistance may be the primary contributors to this condition in type 1 and type 2 diabetes, respectively.17644622
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingApart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men.17646192
Hypercholesterolemia, atheroscleroticDeregulated Nutrient SensingLow apelin levels in hypercholesterolemia seem associated with insulin resistance, which needs to be investigated in larger populations as well as in other atherosclerotic conditions.17647139
diabeticDeregulated Nutrient SensingPreheparin lipoprotein lipase mass is a practical marker of insulin resistance in ambulatory type 2 diabetic patients treated with oral hypoglycemic agents.17651713
AtherosclerosisDeregulated Nutrient SensingAdipocyte cytokines regulate glucose metabolism and insulin resistance and adiponectin is thought to have a protective effect against atherosclerosis.17651832
Increased insulin level, HyperglycemiaDeregulated Nutrient SensingThese mutant mice also showed obesity-independent insulin resistance, hyperinsulinemia, impaired glucose tolerance, age-dependent hyperglycemia, and shortened life span.17652166
Complication Aspects, Coronary heart disease, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMany HIV-infected patients on highly active antiretroviral therapy (HAART) experience metabolic complications including dyslipidaemia and insulin resistance, which may increase their coronary heart disease (CHD) risk.17652317
Kidney Failure, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance and low HDL-cholesterol are also common in chronic kidney disease (CKD), but it is not clear whether they are early or late phenomenons in the development of renal failure.17653600
Renal Insufficiency, DyslipidemiasDeregulated Nutrient SensingThese findings suggest that even early impairment of renal function may be associated with insulin resistance and dyslipidemia, regardless of renal albumin leakage.17653600
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingLow HDL-cholesterol (HDL-C) is frequently accompanied by high triacylglycerol levels in diabetic dyslipidaemia, increasing the risk of CHD.17653691
Critical IllnessDeregulated Nutrient SensingCorrelation of calculated indices of insulin resistance (QUICKI and HOMA) with the euglycaemic hyperinsulinaemic clamp technique for evaluating insulin resistance in critically ill patients.17655809
Critical IllnessDeregulated Nutrient SensingInsulin resistance was measured in 30 critically ill medical patients by the euglycaemic hyperinsulinaemic clamp technique (M-value) as well as calculated using QUICKI and HOMA.17655809
Critical IllnessDeregulated Nutrient SensingAlthough QUICKI and HOMA indicated insulin resistance in the critically ill medical patients, both indices did not correlate with the M-value.17655809
Critical IllnessDeregulated Nutrient SensingTherefore, the euglycaemic hyperinsulinaemic clamp technique remains the gold standard for estimating insulin resistance in critically ill patients.17655809
Diabetes Mellitus, Non-Insulin-Dependent, Increased insulin level, Breast CarcinomaDeregulated Nutrient SensingIt has been suggested that type 2 diabetes may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia.17659440
Steatohepatitis, ObesityDeregulated Nutrient SensingThese results support the concept that obesity predisposes to hepatic steatosis; but in addition, insulin resistance beyond that induced by obesity alone and a relatively high ratio of truncal-to-lower body fat usually combined with obesity to produce an elevated liver fat content.17659597
Hyperhomocystinemia, DyslipidemiasDeregulated Nutrient SensingIn conclusion, a high homocysteine level is an independent and important risk factor of CAD and the relative risk of CAD conferred by homocystinemia is similar to that of dyslipidemia in the Chinese population at high risk of CAD.17659928
Overweight, Insulin resistance syndromeDeregulated Nutrient SensingThe prevalence of overweight, high blood pressure and insulin-resistance syndrome was 16.6 %, 3.7 % and 1.2 %, respectively.17663905
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn multivariate analysis, allogeneic HSCT (RR: 14.5; P =.003), and at least 2 of 4 cardiovascular risk factors (hypertension, dyslipidemia, diabetes, obesity) (RR: 12.4; P =.02) were associated with a higher incidence of arterial events after HSCT.17664354
LipolysisDeregulated Nutrient SensingInsulin resistance, associated with increased lipolysis, results in a high exposure of nonadipose tissue to lipids.17666465
AtherosclerosisDeregulated Nutrient SensingRate of change and instability in body mass index, insulin resistance, and lipid metabolism as predictors of atherosclerotic vascular disease.17666474
Hypertrophic CardiomyopathyDeregulated Nutrient SensingThe report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic cardiomyopathy, glycogen storage, and "pseudo PHK deficiency" prompted us to screen this gene in our patient.17667862
Hepatitis C, ChronicDeregulated Nutrient SensingSuppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy.17668875
Obesity, Hypertension, CTCAE, Disease, Cardiovascular DiseasesDeregulated Nutrient SensingSA is a common disorder associated with major morbid conditions, including hypertension, obesity, cardiovascular disease, and insulin resistance.17669711
Glucose Intolerance (disease), Liver carcinoma, Hepatitis CDeregulated Nutrient SensingSignificance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection.17671700
Liver carcinoma, Communicable Diseases, Glucose Intolerance (disease), Hepatitis C, FAM126A geneDeregulated Nutrient SensingGlucose intolerance frequently is found in hepatocellular carcinoma (HCC) patients with hepatitis C virus (HCV) infection; however, the significance of glucose intolerance remains unclear.17671700
Glucose Intolerance (disease), Hepatitis C, FAM126A geneDeregulated Nutrient SensingTo assess the significance of glucose intolerance, we analyzed 118 HCC patients with HCV infection.17671700
Glucose Intolerance (disease), FAM126A geneDeregulated Nutrient SensingIn conclusion, this study is the first to demonstrate the significance of glucose intolerance in prognosis of male HCC patients and down-regulation of SHIP2 expression in HCC.17671700
Hyperlipidemia, Dyslipidemias, USF1 wt Allele, Coronary Artery DiseaseDeregulated Nutrient SensingFamilial combined hyperlipidemia (FCHL) characterized by high serum total cholesterol and/or triglycerides (TGs) is a common dyslipidemia predisposing to coronary artery disease (CAD).17673701
ObesityDeregulated Nutrient SensingIn this way, it was possible to cope with the insulin resistance caused by anti-psychotic pharmacotherapy (clozapine) and the obesity which had developed as a result of clozapine.17675772
Weight decreasedDeregulated Nutrient SensingAs seen in our patient metformin therapy causes weight loss and decreases insulin resistance.17675772
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPatients in the increasing obesity class had a higher prevalence of diabetes, hypertension and dyslipidemia and were more likely to be women.17680619
diabeticDeregulated Nutrient SensingRelationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.17681171
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingAbdominal fat accumulation (visceral/hepatic) has been associated with hepatic insulin resistance (IR) in obesity and type 2 diabetes (T2DM).17681171
Sleep Apnea, CTCAE, Diabetes MellitusDeregulated Nutrient SensingTreatment for sleep apnea may improve insulin resistance in diabetes mellitus.17682308
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingDyslipidemia, often found in type 2 diabetes mellitus (T2DM) patients, plays an important role in the progression of cardiometabolic syndrome.17684468
Chronic heart failureDeregulated Nutrient SensingEffect of selective and non-selective beta-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure.17694376
Hyperleucinemia, Chronic heart failure, Congestive heart failureDeregulated Nutrient SensingChronic heart failure (CHF) is characterized by increased insulin resistance and hyperleptinaemia.17694376
Congestive heart failureDeregulated Nutrient SensingWe aimed to study effects of selective and non-selective beta-blockers on body weight, insulin resistance, plasma concentrations of leptin and resistin in patients with CHF.17694376
Hepatitis C, Demographics Domain, Liver CirrhosisDeregulated Nutrient SensingCirrhosis of the liver from alcohol and hepatitis C infection, on the other hand, may give rise to insulin resistance or may result in progressive impairment of insulin secretion leading to DM.17694770
Glucose Intolerance (disease), Cerebrovascular accident, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and glucose intolerance are highly prevalent after stroke, contributing to worsening cardiovascular disease risk and a predisposition to recurrent stroke.17702957
Diabetes MellitusDeregulated Nutrient SensingThese preliminary findings suggest that progressive aerobic exercise can reduce insulin resistance and prevent diabetes in hemiparetic stroke survivors.17702957
Hypertension, CTCAE, OverweightDeregulated Nutrient SensingPRINCIPLES AND QUESTIONS UNDER STUDY: The prevalence of overweight is increasing in Swiss children, and they are at increased risk for hypertension and insulin resistance.17705105
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingA total of 376 patients with primary dyslipidaemia (209 men), without overt vascular disease, had their cardiovascular risk estimated using the Framingham equation.17708367
Rheumatism, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Peripheral Arterial Diseases, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Heart failure, Malignant Neoplasms, Kidney Diseases, Alcohol abuse, Hypertension, CTCAEDeregulated Nutrient SensingExclusion criteria were diabetes mellitus, hypertension, dyslipidemia, evident stroke, smoking, documented coronary artery disease, history of myocardial infarction, heart failure, acute or chronic infection, malignancy, peripheral artery disease, renal disease, rheumatologic diseases, alcohol abuse, and certain drugs that may affect endothelial function.17711428
TG gene, DyslipidemiasDeregulated Nutrient SensingThe decreasing order of dyslipidemia prevalence of the two communities was: elevated TG, decreased HDL-C, elevated LDL-C and TC.17711685
TG gene, DyslipidemiasDeregulated Nutrient SensingDyslipidemia of the two communities was TG and decreased.17711685
Ventricular hypertrophy, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertensive (finding)Deregulated Nutrient SensingThe sedentary lifestyle, smoking, high body mass index, dyslipidemia were found in 52.5%, 34.4%, 31.8%, 24.5%, and microproteinuria, left ventricular hypertrophy, coronary artery disease and diabetes in 21.0%, 23.6%, 20.1%, 26.7% hypertensive patients, respectively.17711690
HyperglycemiaDeregulated Nutrient SensingInsulin resistance is commonly cited as the mechanism for hyperglycemia, a theory supported by the efficacy of insulin- sensitizing medications in reported cases.17713311
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingPositive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia.17714716
Dyslipidemias, Diabetes Mellitus, diabeticDeregulated Nutrient SensingThailand diabetes registry project: current status of dyslipidemia in Thai diabetic patients.17715835
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingTo determine the prevalence of dyslipidemia in adult Thai type 2 diabetes who attended diabetes clinics in university and tertiary-care hospitals.17715835
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe overall prevalence of dyslipidemia found in this population was 73.3%, hypertension was 63.3% and obesity (BMI >25 kg/m2) was 52.6%.17717877
Dyslipidemias, Complications of Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of dyslipidemia and hypertension were high in this population, which may be associated with the high prevalence of diabetic complications.17717877
Obesity, Diabetes MellitusDeregulated Nutrient SensingElevated LDL-cholesterol level predicts diabetes in centrally obese women but not men: relative roles of insulin resistance and central obesity.17721029
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingBaseline clinical characteristics did not differ between groups except for more frequent hypertension and dyslipidemia in controls.17721626
Disease, Diabetes MellitusDeregulated Nutrient SensingIn an attempt to understand how specific variants of different genes interact and intervene in the molecular and physiological mechanisms of disorders such as diabetes or insulin resistance, the search for gene-gene interactions is constantly growing.17727676
Peripheral Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was found to independently affect occurrence of PVD (OR = 5.37, [95% CI 1.05-27.5], P = 0.05).17728365
Dyslipidemias, Gastritis, XanthomatosisDeregulated Nutrient SensingTo investigate the relationship among gastric xanthomatosis (GX), H pylori, dyslipidemia, and gastritis in Korea, a well-known H pylori endemic area.17729413
Dyslipidemias, Infection caused by Helicobacter pylori, Gastritis, AtrophicDeregulated Nutrient SensingMoreover, dyslipidemia and atrophic gastritis are found to be related to GX, but H pylori infection is not.17729413
Hyperglycemia, Coronary heart disease, Cerebrovascular accidentDeregulated Nutrient SensingOur findings suggest that in women in the 60-79 y age range, insulin resistance, rather than insulin secretion or chronic hyperglycaemia, is a more important risk factor for coronary heart disease and stroke.17760500
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Thyroid Diseases, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of diabetes mellitus, dyslipidemia, hypertension, and thyroid disease is higher in older women, placing these women at increased risk of cardiovascular disease.17762424
Chronic liver disease, Liver carcinomaDeregulated Nutrient SensingImmunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease.17763954
FAM126A geneDeregulated Nutrient SensingImmunohistochemical evidence of activation of the Akt-mTORC1 pathway is associated with HCC.17763954
Angina Pectoris, Dyslipidemias, Diabetes Mellitus, Heart failure, Hypertension, CTCAEDeregulated Nutrient SensingPrevalence of diabetes, hypertension, dyslipidemia, and heart failure was similar among the anginal post-EECP anginal classes.17765644
Dyslipidemias, AlbuminuriaDeregulated Nutrient SensingAmelioration of albuminuria may be related to specific constellations of risk factors including race and dyslipidaemia.17766000
Metabolic Syndrome XDeregulated Nutrient SensingIn the US population, apoB/apoAI ratio is significantly associated with insulin resistance in non-diabetic subjects, independently of the traditional risk factors, metabolic syndrome components, and inflammatory risk factors.17766927
Ischemia, DyslipidemiasDeregulated Nutrient Sensing[Correlation of dyslipidemia in patients with critical ischemia in Hospital Barao de Lucena - Recife/PE].17768802
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThere are studies that confirm the association between dyslipidaemia and the genesis of atherosclerosis process in world literature.17768802
Ischemia, DyslipidemiasDeregulated Nutrient SensingThe goal of this study is to evaluate the incidence of the dyslipidaemia in patients with critical limb ischemia.17768802
Renal Insufficiency, InflammationDeregulated Nutrient SensingResistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction.17785630
Inflammation, Coronary heart diseaseDeregulated Nutrient SensingThis association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation.17785630
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingTreatment of hypertension and dyslipidemia or their combination among US managed-care patients.17786069
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes arises when insulin resistance-induced compensatory insulin secretion exhausts.17786204
Beta-cell dysfunctionDeregulated Nutrient SensingInsulin resistance and/or beta-cell dysfunction result from the interaction of environmental factors (high-caloric diet and reduced physical activity) with a predisposing polygenic background.17786204
Beta-cell dysfunctionDeregulated Nutrient SensingHowever, associations of these variations with insulin resistance and/or beta-cell dysfunction were not assessed.17786204
EXT2 gene, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingIn contrast, the other reported type 2 diabetes candidate SNPs within the EXT2 and LOC387761 loci did not associate with insulin resistance or beta-cell dysfunction, respectively.17786204
Dyslipidemias, diabetic, Cardiovascular systemDeregulated Nutrient SensingDiabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths.17786383
DyslipidemiasDeregulated Nutrient SensingThis investigation is an attempt to evaluate the diagnostic value of HbA(1c) in predicting diabetic dyslipidemia.17786383
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThe proportion of patients with hyperglycemia and dyslipidemia was not significantly different between the 2 groups.17803009
Diabetes Mellitus, Non-Insulin-Dependent, atherosclerotic, Diabetes MellitusDeregulated Nutrient SensingThe evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes.17823381
Dyslipidemias, diabeticDeregulated Nutrient SensingWe may expect better management of oral health in diabetic patients with control of dyslipidemia in addition to blood glucose.17827833
Non-alcoholic Fatty Liver Disease, Demographics DomainDeregulated Nutrient SensingObese patients with type 2 DM and insulin resistance develop more severe NAFLD and early sinusoidal fibrosclerosis.17846888
Failure (biologic function)Deregulated Nutrient SensingThe 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth.17848410
Hypertension, CTCAEDeregulated Nutrient SensingPreterm birth is associated with postnatal growth failure, abdominal fat accumulation, insulin resistance, and hypertension, resembling increased glucocorticoid bioactivity.17848410
Increased insulin level, Rabson-Mendenhall Syndrome, Hyperglycemia, Congenital AbnormalityDeregulated Nutrient SensingRabson-Mendenhall syndrome is a rare genetic disorder characterized by severe insulin resistance, extreme hyperinsulinemia, postprandial hyperglycemia, growth retardation, and dysmorphisms.17849153
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRisk factors included hypertension (11 patients, 58%), smoking (14, 74%), diabetes (6, 30%), and dyslipidemia (12, 63%).17849948
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSome studies indicate that the Trp64Arg polymorphism in the gene encoding the beta3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.17852419
Dyslipidemias, Cerebrovascular accident, Coronary Artery Disease, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingThese patients were older, had more rate of hypertension, dyslipidemia, coronary arterial disease, peripheral vascular disease and previous stroke than non-diabetic patients.17853961
InflammationDeregulated Nutrient SensingC-reactive protein (CRP) was also measured since systemic inflammation is associated with insulin resistance in non-renal patients and inflammation is negatively modulated by ghrelin in experimental models.17854954
HyperglycemiaDeregulated Nutrient SensingOverdoses of calcium channel blocker agents result in hyperglycemia, primarily due to the blockade of pancreatic L-type calcium channels and insulin resistance on the cellular level.17855820
DyslipidemiasDeregulated Nutrient SensingOn the basis of a high correlation, non-HDL-C (non-high-density lipoprotein cholesterol) and apoB (apolipoprotein B) have been suggested to be of equivalent value for clinical practice; however, the strength of this relationship has not been examined in detail in patients with dyslipidaemia.17868037
ObesityDeregulated Nutrient SensingAssociation between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.17870627
ObesityDeregulated Nutrient SensingWe found that the individual polymorphisms were not associated with obesity, but the (-866G; rs659366)-(Del; 45bp)-(-55T; rs1800849) haplotype was significantly associated with obesity and its presence in the control group increased about nine times the insulin resistance risk.17870627
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingThe interplay of insulin resistance and beta-cell dysfunction involves the development of type 2 diabetes in Chinese obeses.17873317
Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingAbdominal obesity, insulin resistance and hypertension: impact on left ventricular mass and function in women.17874012
Hypertension, CTCAE, Electrocardiogram: left ventricle hypertrophy (finding), ObesityDeregulated Nutrient SensingOur results indicate an association among hypertension, central obesity and left ventricular hypertrophy through increases in sympathetic activity and insulin resistance.17874012
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe retinol-binding protein 4 (RBP4) has been linked to the insulin resistance state in obesity and type 2 diabetes in animal studies.17875187
Schizophrenia, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Bipolar DisorderDeregulated Nutrient SensingCompared with schizophrenia patients, those with bipolar disorder were 19% more likely to have diabetes, 44% more likely to have coronary artery disease, and 18% more likely to have dyslipidemia, after adjustment.17878500
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus.17878672
Aortic Stiffness, diabeticDeregulated Nutrient SensingWe tested the hypothesis that tHcy correlates with aortic stiffness and insulin resistance in type 2 diabetic patients.17884450
Diabetes Mellitus, Non-Insulin-Dependent, Aortic StiffnessDeregulated Nutrient SensingIn conclusion, our results indicate that the elevated level of tHcy in Japanese patients with type 2 diabetes mellitus is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV and the HOMA index are independent predictors of tHcy.17884450
diabeticDeregulated Nutrient SensingDiabetic rat studies suggest that skeletal muscle neuronal NOS (nNOS) micro protein expression may be reduced in human insulin resistance.17884453
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingBoth ectopic fat accumulation and changes of the amount of several adipocyte secreting proteins (adipokines) are thought to contribute to the development of insulin resistance associated with obesity and type 2 diabetes mellitus.17884455
diabeticDeregulated Nutrient SensingContribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging.17884459
Dyslipidemias, LYST wt AlleleDeregulated Nutrient SensingWhereas there was little association between USF1 genotype and metabolic or CVD traits in older adults from CHS, the USF1 low-risk dyslipidemia allele was associated with higher plasma C-reactive protein and interleukin (IL)-6 levels and with increased risk of mortality, particularly attributable to noncardiovascular causes.17885212
Proteinuria, DyslipidemiasDeregulated Nutrient SensingProteinuria and dyslipidemia are nonimmune risk factors implicated in the deterioration of kidney function and associated with an increased risk of accelerated atherogenesis.17889157
Hypertension, CTCAE, Myocardial Ischemia, DyslipidemiasDeregulated Nutrient SensingThe incidence of arterial hypertension and dyslipidemia was higher among ischemic heart disease recipients.17889185
Dyslipidemias, HaitiDeregulated Nutrient SensingDyslipidemia is a common problem among heart transplant (HT) recipients; it is a frequent risk factor in these patients that is exacerbated by immunosuppressive drugs.17889199
Dyslipidemias, HaitiDeregulated Nutrient SensingStatins are effective drugs to treat dyslipidemia in HT recipients, but control is suboptimal in some patients.17889199
TG geneDeregulated Nutrient SensingDespite similar levels of total body fat, non-obese women had lower systolic blood pressure, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL)-cholesterol levels, insulin resistance indices, and RBP4 levels than non-obese women with visceral adiposity and had higher high-density lipoprotein-cholesterol levels.17890490
TG geneDeregulated Nutrient SensingSimilarly, obese women without visceral adiposity had lower blood pressure, total cholesterol, TG levels, insulin resistance indices, and RBP4 levels than obese women with visceral adiposity.17890490
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe frequency of smoking, hypertension, and dyslipidemia was similar across groups.17894012
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMuscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study.17895577
diabeticDeregulated Nutrient SensingOur data suggest that lower-extremity muscle strength is independently associated with insulin resistance, which seems to be consistent with previous reports that resistance training improves glycemic control in type 2 diabetic patients.17895577
Weight decreasedDeregulated Nutrient SensingTherapy with exenatide often results in weight loss, which further assists in decreasing insulin resistance.17896900
Weight Gain, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThis weight gain led to insulin resistance and the development of type 2 diabetes; thus he had characteristics of both types 1 and 2 diabetes, or double diabetes.17896900
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Blood GlucoseDeregulated Nutrient SensingWe sought to determine whether childbearing increases incidence of type 2 diabetes after accounting for preconception glycemia and gestational glucose intolerance.17898128
Hypertension, CTCAEDeregulated Nutrient SensingStudy on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution.17898946
Hypertensive (finding)Deregulated Nutrient SensingDecrease of insulin sensitivity and increase of insulin resistance are more obvious in hypertensive patients with genotype G of the 3 genes of SM constitution than in those of PI constitution.17898946
Hypertensive (finding)Deregulated Nutrient SensingTherefore, the difference in constitution might be one of the genetic characteristics for insulin resistance in hypertensive patients.17898946
Breast CarcinomaDeregulated Nutrient SensingIt is unclear whether associations between sedentary time or physical activity and percent breast density are mediated through serum insulin levels or insulin resistance, factors also associated with physical activity and breast cancer risk.17903077
Albuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpaired flow-mediated vasodilatation and insulin resistance in type 2 diabetic patients with albuminuria.17904244
Diabetic Nephropathy, Endothelial dysfunction, Atherosclerosis, diabeticDeregulated Nutrient SensingThese results suggested that endothelial dysfunction which may be due to impaired NO production and insulin resistance underlie the association between diabetic nephropathy and atherosclerosis in diabetic patients.17904244
Increased insulin level, Pancreatic carcinomaDeregulated Nutrient SensingHyperinsulinemia and insulin resistance have been proposed as underlying mechanisms for the increase in pancreatic cancer among long-standing diabetics and obese individuals.17905943
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study showed improvements in glycaemic control and dyslipidaemia in patients with type 2 diabetes poorly controlled with existing sulphonylurea therapy.17907109
Microalbuminuria, Obesity, VisceralDeregulated Nutrient SensingT2DM in young people is associated with marked visceral obesity, insulin resistance and microalbuminuria.17907114
Acromegaly, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus develops in about 10% of acromegalic patients, usually secondary to insulin resistance caused by growth hormone excess.17908670
Proteinuria, Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingExclusion criteria were absence of gross proteinuria, hypertension, dyslipidaemia or cardiovascular disease.17910281
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingA lower frequency of the PRM -352T allele of the STX1A gene was observed in overweight/obese subjects with impaired glucose regulation, particularly among individuals with combined glucose intolerance and overt diabetes.17912268
Increased insulin level, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHomologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a rat model of type 2 diabetes mellitus.17913278
Kidney FailureDeregulated Nutrient Sensing[Renal failure and insulin resistance: effect of the dialysis dose].17915164
Chronic Kidney DiseasesDeregulated Nutrient SensingIn patients with chronic renal failure, adapted dialysis, determined by the Kt/V index, correlated negatively with insulin resistance.17915164
Gestational DiabetesDeregulated Nutrient Sensing[Heterogeneity of insulin resistance level in gestational diabetes mellitus.17915408
Gestational DiabetesDeregulated Nutrient SensingThe evaluation of insulin resistance (IR) level in population of women with gestational diabetes(GDM) and its relation to treatment of GDM.17915408
Gestational DiabetesDeregulated Nutrient SensingBoth, frequency of insulin therapy and daily insulin doses are associated with insulin resistance level at the GDM diagnosis.17915408
TG gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe investigated the association between the serum butyrylcholinesterase (BChE) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) in Japanese patients with type 2 diabetes and non-diabetic subjects.17917325
AcromegalyDeregulated Nutrient SensingInsulin resistance index and fibrinogen levels were higher in patients with active acromegaly than patients and subjects in control groups.17917813
Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and diabetes mellitus have recently been reported to affect cognition in patients with hepatitis C cirrhosis awaiting liver transplantation.17919230
muscle massDeregulated Nutrient SensingPlasma ammonium ion levels were related to insulin resistance (r=0.42, P<0.001) and muscle mass (r=0.28, P=0.003).17919230
heliumDeregulated Nutrient SensingNutritional status and insulin resistance might be implicated in the pathogenesis of HE.17919230
Communicable Diseases, Hepatitis CDeregulated Nutrient SensingHepatitis C virus (HCV) infection causes insulin resistance.17919242
Liver carcinoma, Hepatitis CDeregulated Nutrient SensingBecause increased insulin resistance is a risk factor for development of hepatocellular carcinoma and reduced long-term survival, insulin resistance is a therapeutic target in patients with HCV infection.17919242
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe study population comprised patients within the General Practice Research Database who began treatment for hypertension, dyslipidaemia or both between 1997 and 2001.17919356
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingNevertheless, there is a large unmet need for initiating and maintaining antihypertensive and lipid-lowering therapy in patients with hypertension and dyslipidaemia.17919356
DyslipidemiasDeregulated Nutrient SensingEligible patients were those treated pharmacologically for dyslipidemia in the Cegedim Strategic Data general practice network.17919548
Dyslipidemias, Diabetes Mellitus, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPatients with diabetes had a similarly increased risk of mixed dyslipidemias, whereas patients with a history of CHD did not.17919548
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients with a greater number of nonlipid CV risk factors or with diabetes had a significantly increased risk of mixed dyslipidemias involving elevated TGs and/or low HDL-C in addition to elevated LDL-C.17919548
DyslipidemiasDeregulated Nutrient SensingThe effect of pioglitazone as add-on therapy to metformin or sulphonylurea compared to a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia.17919894
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingDiabetic dyslipidaemia contributes to the increased risk of cardiovascular disease in patients with Type 2 diabetes.17919894
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis paper examines the effectiveness of adding pioglitazone to metformin or a sulphonylurea (SU) compared with a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia in patients with Type 2 diabetes.17919894
Cardiovascular morbidity, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe beneficial effects of pioglitazone on diabetic dyslipidaemia may help combat the increased cardiovascular morbidity and mortality observed in patients with Type 2 diabetes while providing stable glycaemic control.17919894
DyslipidemiasDeregulated Nutrient SensingHigh amounts of dietary fructose may contribute to dyslipidemia in adults, but there are few data in children.17921399
AnemiaDeregulated Nutrient SensingAge- and body mass index-dependent relationship between correction of iron deficiency anemia and insulin resistance in non-diabetic premenopausal women.17921683
AnemiaDeregulated Nutrient SensingNo prospective studies have evaluated the effects of correction of iron deficiency anemia on insulin resistance in non-diabetic premenopausal women.17921683
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBlood pressure measurements, combined with a clinical questionnaire that included educational and socio-economic data, and standard blood samples for the detection of dyslipidemia and diabetes mellitus, were collected.17921815
DyslipidemiasDeregulated Nutrient SensingHowever, dyslipidemia prevalence was significantly higher in the high-education group (27.1% as compared with 16.9% in the lowest-education group; P < 0.01).17923677
Steatohepatitis, Metabolic Syndrome XDeregulated Nutrient SensingThe present study suggests that liver steatosis may be considered with some metabolic risk factors and particularly in the presence of insulin resistance and metabolic syndrome.17923799
Dyslipidemias, Fatty degeneration, Obesity, Diabetes MellitusDeregulated Nutrient SensingSteatosis of the liver has a close association with metabolic conditions such as obesity, dyslipidemia and diabetes mellitus.17923799
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAmong patients with diabetic dyslipidemia plus CHD, the use of statins increased almost threefold instead of a large reduction in the percentage with non-statin class.17924453
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingROC curve analysis suggested WC cut-off points of 85 cm in men and 85 cm in women for the optimum detection of high blood pressure, diabetes and dyslipidaemia.17924868
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRisk factors included hypertension (93.7%), overweight/obesity (54.3%), dyslipidemia (44.9%), diabetes (42.1%), and smoking (24.3%).17925609
Hypertensive (finding), Heart failure, Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance independently predicts heart failure and coronary disease, and has been related to thick left ventricular walls, mainly in studies of hypertensive samples not fully accounting for the influence of blood pressure.17932091
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCerebral arterial pulsatility and insulin resistance in type 2 diabetic patients.17933415
diabeticDeregulated Nutrient SensingThe aim of the present study was to investigate the association of insulin resistance with the pulsatility index (PI) of cerebral arteries in type 2 diabetic patients.17933415
diabeticDeregulated Nutrient SensingThe PI was significantly higher in diabetic patients than in healthy controls (p<0.05) and also higher in patients with insulin resistance than that seen in insulin sensitive diabetic patients (p<0.05).17933415
Cerebrovascular, Diabetes MellitusDeregulated Nutrient SensingPI could be a useful marker in the detection of diabetic cerebrovascular changes, and insulin resistance showed correlations with PI, but age and the duration of diabetes contributed independently to the variability in the PI.17933415
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHowever, little is known about the dyslipidaemia associated with stroke in South Asians.17935546
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingUsing a case-control study, we investigated features of the dyslipidaemia in South Asian patients with stroke compared with South Asian subjects with no history of clinically detectable stroke.17935546
Arterial StiffnessDeregulated Nutrient SensingFMD was reduced in FDR, with or without insulin resistance, whereas arterial stiffness was significantly increased only in FDR with insulin resistance.17935958
Glucose Intolerance (disease), Hypertriglyceridemia, Polycystic Ovary SyndromeDeregulated Nutrient SensingBiological testing confirmed glucose intolerance associated with a severe insulin resistance, hypertriglyceridemia and polycystic ovary syndrome.17936664
Lipodystrophy, No metabolic abnormalities, Hypertriglyceridemia, Dermatomyositis, Childhood TypeDeregulated Nutrient SensingLipodystrophy and metabolic abnormalities, primarily hypertriglyceridemia and insulin resistance, have been reported in juvenile dermatomyositis.17938031
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of dyslipidemia and age-adjusted hypertension was lower among Bedouins (5.8% vs. 18.2%, P < 0.01 and 17% vs. 21%, P < 0.001 respectively).17939626
Increased insulin level, Sensorineural Hearing Loss (disorder), Blindness, Cone-Rod Dystrophies, Multiple System Atrophy, Obesity, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlstrom Syndrome is multisystemic, with cone-rod retinal dystrophy leading to juvenile blindness, sensorineural hearing loss, obesity, insulin resistance with hyperinsulinemia, and type 2 diabetes mellitus.17940554
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThere is therefore considerable need for cardiovascular risk-factor intervention, particularly for hypertension and obesity, as well as dyslipidaemia, along with tight metabolic control.17940668
Hyperglycemia, TSC22D3 gene, HyperinsulinismDeregulated Nutrient SensingIn particular, it is not clear whether short-term glucose-induced hyperglycaemia and hyperinsulinaemia as well as a glucocorticoid-induced increase in insulin resistance are reflected in appreciable alterations in serum visfatin levels in humans.17940983
TSC22D3 geneDeregulated Nutrient SensingFurthermore, the results of our study do not support the notion that glucocorticoid-induced insulin resistance is likely to be related to changes in serum concentrations of visfatin.17940983
diabeticDeregulated Nutrient SensingThese data suggest that PPAR-g Pro12Ala may affect blood lipid levels and the abdominal fat storage of diabetic Ugyurs and Kazaks and may be associated with fat storage and insulin resistance in Hans.17941898
Bipolar DisorderDeregulated Nutrient SensingInsulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts.17942838
Bipolar DisorderDeregulated Nutrient SensingTo investigate whether the association between insulin resistance (IR) and depressive symptoms is present already in young adult males.17942838
ObesityDeregulated Nutrient SensingContradictory results have been published regarding the influence of insulin resistance on these rheological parameters in obesity.17942983
Hyperglycemia, Obesity, Visceral, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingKey features are visceral obesity, dyslipidemia, hyperglycemia in the non-diabetic range, and arterial hypertension.17943407
Hyperuricemia, Metabolic Syndrome XDeregulated Nutrient SensingSubjects with hyperuricaemia but not with insulin resistance exhibited an increased risk to develop the metabolic syndrome.17945241
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and type 2 diabetes are associated with decreased expression of genes that regulate oxidative phosphorylation in skeletal muscle.17948130
Diabetes Mellitus, Non-Insulin-Dependent, Gaucher Disease, Type 1Deregulated Nutrient SensingOverweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy.17950007
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSingle nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes.17950019
Diabetes MellitusDeregulated Nutrient SensingAdditionally, the previously described association between the PRKAA2 (AMPK alpha2-subunit) haplotype and type 2 diabetes was tested for replication.17950019
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur findings suggest that genetic variants of LKB1-AMPK-TORC2 pathway components may exert a weak influence on the occurrence of type 2 diabetes in Japanese.17950019
Cardiovascular DiseasesDeregulated Nutrient SensingAdiponectin may play an important role in the regulation of body weight, insulin resistance, and cardiovascular disease.17950098
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient SensingFurthermore, these mice showed a basal hyperglycemia and glucose intolerance which disappeared with age.17950578
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingThis observation suggests that the low HDL-C/low Apo A-I phenotype may result from a genetic defect directly affecting HDL metabolism, even in the context of a dyslipidemia which, like FCHL, is associated with low plasma HDL-C.17950741
Adrenal Androgen Excess, HyperandrogenismDeregulated Nutrient SensingTo ascertain an association between the a priori known insulin resistance caused by antipsychotic agents and divalproex and adrenal hyperandrogenism and to determine whether the associated hyperandrogenism is reversible with insulin sensitizers.17954415
Adrenal Androgen ExcessDeregulated Nutrient SensingInsulin resistance caused by antipsychotic agents and divalproex is associated with adrenal hyperandrogenism.17954415
Hypertension, CTCAE, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingCardiovascular risk factors, particularly hypertension and dyslipidaemia were prevalent in the studied patients with stroke.17957322
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingDiabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity.17958881
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingInsulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT).17959864
Autoimmune Diseases, Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingInsulin resistance can modulate progression to type 1 diabetes in individuals with ongoing islet autoimmunity.17959864
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingThese data suggest that insulin resistance accelerates progression to type 1 diabetes in antibody-positive relatives in whom insulin secretion is markedly reduced but does not affect progression when insulin secretion is relatively well preserved.17959864
Fat-free massDeregulated Nutrient SensingImprovement in HbA(1c) was related to decreased body fat (r = 0.484, P = 0.004) and improvement in insulin resistance was related to decreased body fat (r = 0.37, P = 0.03) and central adiposity (r = 0.38, P = 0.02), as well as increased fat-free mass (r = -0.46, P = 0.005).17965035
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cessation of life, Kidney FailureDeregulated Nutrient SensingPrimary PCI was associated positively with younger age, male sex, known dyslipidemia, and prior PCI (all P < .03), and negatively with diabetes, renal failure, prior myocardial infarction or bypass surgery, and higher predicted death by the Mediqual Atlas Outcomes score (all P < .01).17967609
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere were no significant differences in terms of diabetes mellitus, hypertension, dyslipidemia, plasma fibrinogen level, smoking, gender and family history of CAD with and without the FVL mutation in the patient group.17982311
diabeticDeregulated Nutrient SensingIn the basal condition, in both healthy control individuals and diabetic patients, the whole blood viscosity at higher shear rate (450/s) was significantly correlated in a negative way with the index of insulin resistance (P < 0.05), and in a positive way with the haematocrit value (P < 0.05) and the platelet count (P < 0.01).17982315
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingCurrent smoking was reported by 77.1% of patients, while a history of dyslipidemia, hypertension, or diabetes was found in 29.3%, 7.3%, and 4.9% of patients, respectively.17983529
DyslipidemiasDeregulated Nutrient SensingCompared with APOE*3/*3 homozygotes, patients with the APOE*4 allele had 1.3 times higher risk for CAD after ignoring dyslipidemia, but this risk was modified after adjusting for dyslipidemia.17985658
ARCN1 gene, Primary malignant neoplasm, Demographics Domain, Presenile dementia, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Heart failure, HaitiDeregulated Nutrient SensingData were collected on sociodemographic endpoints, type of dementia, Barthel Index (BI), Lawton Index (LO), Mini-Mental State Examination (MMSE), Charlson Index, total number of drugs, history of high blood pressure (HT), diabetes (DM), dyslipidemia (DL), heart failure (HF), chronic obstructive pulmonary disease (COPD) and cancer.17988595
Dyslipidemias, PsoriasisDeregulated Nutrient SensingDyslipidaemia was present in 50.9% of the patients with psoriasis, compared with 44.2% of the controls (p=0.015).17989888
Overweight, ObesityDeregulated Nutrient SensingConditions such as overweight or obesity in which a degree of insulin resistance may be present may also be important.17991664
DyslipidemiasDeregulated Nutrient SensingA low plasma HDL-cholesterol concentration is a major characteristic of diabetic dyslipidemia.17991668
Hyperlipidemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingFenofibrate, a fibric acid derivative, is used to treat diabetic dyslipidemia, hypertriglyceridemia, and combined hyperlipidemia alone or in combination with statins.17994463
Inflammation, No metabolic abnormalitiesDeregulated Nutrient SensingMore metabolic abnormalities were associated with higher risk of inflammation, urinary albumin, and insulin resistance.17998025
AtherosclerosisDeregulated Nutrient SensingLow concentrations of endogenous androgens have been linked with insulin resistance and atherosclerosis.17998764
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingObesity is associated with insulin resistance, which is the main pathogenic factor for nonalcoholic fatty liver disease (NAFLD).18004085
Weight decreasedDeregulated Nutrient SensingThe results demonstrate that weight loss results in a decrease in normal ALT levels as well as insulin resistance.18004085
Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingDue to a vicious circle in which HCV favors insulin resistance and, alternatively, insulin resistance facilitates the persistence of HCV, HCV patients have often diabetes associated with liver cirrhosis.18018363
AtherosclerosisDeregulated Nutrient SensingInsulin resistance is associated with a variety of atherosclerosis risk factors.18024935
ObesityDeregulated Nutrient SensingVisceral obesity increases risk of insulin resistance and type 2 diabetes.18025413
Fatty Liver, Muscle hypertrophyDeregulated Nutrient SensingIt is characterized by a lack of adipose tissue throughout the body from birth, muscular hypertrophy, advanced bone age, fatty liver, and insulin resistance.18026908
Steatohepatitis, Hepatitis BDeregulated Nutrient SensingAssociation of chronic hepatitis B virus infection with insulin resistance and hepatic steatosis.18028349
Virus Diseases, HIVDeregulated Nutrient SensingChronic viral infections such as human immunodeficiency virus and hepatitis C virus (HCV) may decrease tissue response to insulin, thereby causing insulin resistance.18028349
SteatohepatitisDeregulated Nutrient SensingIn addition, insulin resistance is associated with hepatic steatosis.18028349
SteatohepatitisDeregulated Nutrient SensingThe present study therefore aimed to investigate the association of chronic HBV infection with insulin resistance and hepatic steatosis.18028349
SteatohepatitisDeregulated Nutrient SensingChronic HBV infection seems not to be associated with insulin resistance or hepatic steatosis in HBV carriers.18028349
Oxygen saturation below reference rangeDeregulated Nutrient SensingFatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance.18030445
Dyslipidemias, ObesityDeregulated Nutrient SensingAnimal and human data implicate hepatic desaturase activities in insulin resistance, obesity and dyslipidaemia.18030445
Blood coagulationDeregulated Nutrient SensingFibrates produce additional actions such as reduction of inflammatory state, insulin resistance and activation of blood coagulation, along with stimulation of fibrinolysis.18030873
Lipodystrophy, Aortic Valve Stenosis, Hypertrophic CardiomyopathyDeregulated Nutrient SensingA novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy.18031308
Aortic Valve Stenosis, Hypertrophic CardiomyopathyDeregulated Nutrient SensingThe patient showed atypical fat distribution, insulin resistance, severe aortic stenosis and hypertrophic cardiomyopathy.18031308
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia and other cardiovascular risk factors in a Canadian First Nation pediatric population with type 2 diabetes mellitus.18036065
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe objectives of this study were to describe the prevalence of dyslipidemia in a population of youth with type 2 diabetes mellitus (T2DM) and to examine the relationship between the lipid parameters and other known cardiovascular risk factors.18036065
Nonketotic Hyperglycinemia, Systolic hypertension, ObesityDeregulated Nutrient SensingThe proband was a 13.5-yr-old boy with marked non-ketotic hyperglycemia, obesity, systolic hypertension, and insulin resistance.18036134
HyperglycemiaDeregulated Nutrient SensingIn utero hyperglycemia has been associated with insulin resistance (IR) in children; however, there are limited data in low-risk populations.18036135
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidaemia did not discriminate survival amongst South Asian patients.18036165
Fatty Liver, Dyslipidemias, Glucose Intolerance (disease), Obesity, Hypertension, CTCAEDeregulated Nutrient SensingAt the time of the baseline examinations, significant clinical associations were found between fatty liver and obesity (p<0.001), hypertension (p<0.001), dyslipidemia (p<0.001), and glucose intolerance (p<0.001).18037775
Sensorineural Hearing Loss (disorder), square decimeter, Fatty Liver, Autosomal Recessive Disorder, Obesity, Retinitis Pigmentosa, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlstrom syndrome (AS) is an autosomal recessive disorder characterized by progressive pigmentary retinopathy, sensorineural hearing loss, fatty liver infiltration, obesity, insulin resistance and early-onset type 2 diabetes mellitus (DM2).18038714
square decimeterDeregulated Nutrient SensingEarly onset of insulin resistance and DM2 are key components of this syndrome.18038714
square decimeterDeregulated Nutrient SensingWe suggest that early initiation of combined therapy comprising a high dose of metformin plus rosiglitazone may be valuable in managing insulin resistance and DM2 in children with AS.18038714
Failure (biologic function), Beta-Cell Function MeasurementDeregulated Nutrient SensingSecondary treatment failure is often attributed to the development of obesity-related insulin resistance in combination with continued loss of beta-cell function.18039725
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance is frequently observed in patients with essential hypertension (EHT), and the renin-angiotensin system (RAS) has been demonstrated to modulate the status of insulin resistance.18041161
Increased insulin levelDeregulated Nutrient SensingHowever, there was no significant relationship between PRA and indices of insulin resistance and hyperinsulinemia in patients with RVHT.18041161
Coronary Artery DiseaseDeregulated Nutrient SensingThe effects of exercise training on insulin resistance in patients with coronary artery disease.18043303
Weight decreasedDeregulated Nutrient SensingTwelve weeks of moderate exercise training in the absence of weight loss did not result in significant change in insulin resistance in patients with CAD.18043303
Kidney Failure, ChronicDeregulated Nutrient SensingWe have used a randomised, matched-paired, double-blind, placebo-controlled experimental design to determine the capability of intravenous L-carnitine supplementation to modify insulin resistance and protein catabolism in non-diabetic patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis treatment.18045815
Peripheral Vascular Diseases, Dyslipidemias, MicroalbuminuriaDeregulated Nutrient SensingOdd ratios further increased, again as expected, with dyslipidemia (2.19; 95% CI, 1.54-3.12; P<.0001), peripheral arterial disease (2.61; 95% CI, 1.77-3.85; P<.0001), microalbuminuria (3.03; 95% CI, 1.91-4.82; P<.0001), and abnormal electrocardiographic findings (3.06; 1.68; 95% CI, 2.08-4.48; P<.0001).18046097
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSmall molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.18046409
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes.18046409
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingMen were more likely to smoke and have a history of heart disease and dyslipidemia.18048851
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSmoking was observed more in men (72 vs 26%) and systemic arterial hypertension in women (65 vs 48%), There were no differences in diabetes mellitus and dyslipidemia frequencies.18050935
Diabetes MellitusDeregulated Nutrient SensingIncidence of childhood diabetes increased between 1994-2003, driven primarily by nT1, suggesting a role for behavioral and/or environmental determinants of insulin resistance.18051928
ObesityDeregulated Nutrient SensingRecently, local renin-angiotensin system of adipose tissue has been suggested as a possible contributor to the development of insulin resistance in patients with obesity.18052686
Inflammation, diabeticDeregulated Nutrient SensingTo avoid an increase in insulin resistance, it seems important to attend to radically non-vital teeth as well as any other dental inflammation in diabetic patients.18052712
DyslipidemiasDeregulated Nutrient SensingWe also modeled the effect of treating obesity-related increases in blood pressure and dyslipidemia.18057339
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingFor dyslipidaemia and hyperuricaemia, the corresponding figures were 331 (54%) and 191 (31%).18057428
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingIn total, 264 (43%) patients were newly diagnosed as having dysglycaemia, dyslipidaemia, or hyperuricaemia.18057428
Diabetes MellitusDeregulated Nutrient SensingAndrogen excess is associated with insulin resistance and the development of diabetes in African American women.18059208
Diabetes MellitusDeregulated Nutrient SensingThis prospective study demonstrates that relative androgen excess is associated with insulin resistance and increases the risk for development of diabetes in premenopausal African American women.18059208
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects.18060751
Increased insulin levelDeregulated Nutrient SensingWe evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects.18060751
Increased insulin levelDeregulated Nutrient SensingSubjects with isolated insulin resistance had also higher BP whereas subjects with isolated hyperinsulinemia had lower BP.18060751
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia and insulin resistance might contribute with distinct and independent mechanisms to the development of several metabolic and hemodynamic disorders often clustering in the same individual.18060751
Increased insulin level, Hyperuricemia, Hypertriglyceridemia, Hypertension, CTCAEDeregulated Nutrient SensingIn particular, hypertriglyceridemia, low HDL-cholesterol and hyperuricemia seem to be related to both hyperinsulinemia and insulin resistance, whereas hypertension seems to be related only to insulin resistance.18060751
InflammationDeregulated Nutrient SensingOne possible mediator may be inflammation, but longitudinal data relating FA composition to inflammation taking insulin resistance into account are limited.18062827
Bipolar DisorderDeregulated Nutrient SensingInsulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study.18063093
Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDepression is associated with an increased risk of incident diabetes, and insulin resistance is thought to be the underlying link between them.18063093
Kidney DiseasesDeregulated Nutrient SensingBody mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients.18065581
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance has been noted in patients with chronic kidney disease (CKD).18065581
Chronic Kidney DiseasesDeregulated Nutrient SensingThe determinants of insulin resistance have not been well-studied in CKD patients.18065581
Diabetes MellitusDeregulated Nutrient SensingThe objective of this study was to examine the degree and determinants of insulin resistance in persons without diabetes but with stage 3-4 CKD.18065581
Chronic Kidney DiseasesDeregulated Nutrient SensingWhereas insulin resistance is highly prevalent in stage 3-4 CKD, the primary determinant of insulin resistance in this population is BMI, specifically, fat mass.18065581
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe following prevalences were found: hypertension: 14.7%; diabetes: 2.3%; dyslipidemia: 18.7%; obesity: 15.6%; increased waist circumference: 24.1%; and smoking: 15.6%.18066452
DyslipidemiasDeregulated Nutrient SensingAnacetrapib produced dose-dependent lipid-altering effects with peak lipid-altering effects of 129% (mean 51.1 [SD 3.8]-114.9 [7.9] mg/dL) increase in HDL-C and a 38% (138.2 [11.4]-77.6 [7.9] mg/dL) decrease in LDL-C in patients with dyslipidaemia.18068514
Inflammation, ObesityDeregulated Nutrient SensingOur findings suggest that severe insulin resistance of Mc4rKO fed a HFD, as reported in other models of obesity such as leptin-deficient (Lep(ob)/Lep(ob)) and KK-A(y) mice, is linked to reduced serum adiponectin and high levels of inflammation in adipose tissue.18070757
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFunctional studies suggest that the nonsynonymous K121Q polymorphism in the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) may confer susceptibility to insulin resistance; genetic evidence on its effect on type 2 diabetes, however, has been conflicting.18071025
Weight decreasedDeregulated Nutrient SensingThe amelioration of insulin resistance in this group could not be totally explained by weight loss.18071341
Lipodystrophy, Hyperlipidemia, Diabetes MellitusDeregulated Nutrient SensingPartial lipodystrophy (PL) is most commonly characterized by loss of subcutaneous fat in the extremities with preservation of truncal fat and is associated with insulin resistance, diabetes and hyperlipidaemia.18076675
Chronic Kidney Diseases, Hyperuricemia, ObesityDeregulated Nutrient SensingThe prevalence of obesity, hyperuricemia, chronic kidney disease (CKD), insulin resistance and MS was 42.2, 31.2, 30.9, 36.0 and 47.5%, respectively.18082342
Chronic Kidney Diseases, HyperuricemiaDeregulated Nutrient SensingMale gender, CKD, BMI>23 kg/m(2) and insulin resistance were all independent risk factor for hyperuricemia with the covariate of age.18082342
Chronic Kidney Diseases, HyperuricemiaDeregulated Nutrient SensingWhen age and BMI were controlled, females had significantly higher prevalence of CKD and insulin resistance, but less hyperuricemia than males (P all<0.05).18082342
HyperuricemiaDeregulated Nutrient SensingAdjusted for age, BMI and GFR, hyperuricemia and MS were both independent risk factors for insulin resistance in females (P=0.006, <0.001, respectively).18082342
HyperuricemiaDeregulated Nutrient SensingIn males, MS remained significantly associated with insulin resistance (P=0.002) but not hyperuricemia (P=0.813).18082342
HyperuricemiaDeregulated Nutrient SensingStudies related to insulin resistance may be needed when hyperuricemia was identified in older women.18082342
Dyslipidemias, ObesityDeregulated Nutrient Sensing[Screening for dyslipidemia based on family history combined with obesity in children].18087547
Dyslipidemias, ObesityDeregulated Nutrient SensingTo explore the significance of family history combined with obesity in screening dyslipidemia in children.18087547
Hyperlipidemia, Hypercholesterolemia, Dyslipidemias, HypertriglyceridemiaDeregulated Nutrient SensingThe percentages of dyslipidemia in non-obese children without family history, non-obese children with family history, obese children without family history, and obese children with family history were as follows: hyperlipidemia: 7.9%, 9.6%, 30.1% and 31.5%, respectively; hypercholesterolemia: 0.9%, 1.5%, 3.3% and 2.9%, respectively; hypertriglyceridemia: 7.1%, 8.6%, 29.2% and 31.3% respectively.18087547
Dyslipidemias, ObesityDeregulated Nutrient SensingFamily history combined with obesity is important in identifying dyslipidemia in children.18087547
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingA missense mutation of the human ADRB3 gene replacing tryptophan with arginine at codon 64 (Trp64Arg) has been related to obesity, insulin resistance, earlier onset of noninsulin-dependent diabetes mellitus and hypertension.18088254
HypertriglyceridemiaDeregulated Nutrient SensingPostprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs).18089891
Diabetes MellitusDeregulated Nutrient SensingAdjusted for age, sex, family history of diabetes, race/ethnicity, income and education, insulin resistance was reduced by 17% (95% confidence interval = -31% to -1%) for an increase from the 10th to 90th percentiles of resources.18091002
Microalbuminuria, ObesityDeregulated Nutrient SensingUAE of 10-29 mg/day (hyperalbuminuria), below the conventionally used limit to define microalbuminuria, is already associated with a more adverse cardiovascular risk profile, and is exquisitely sensitive to interventions that reduce obesity, BP, and insulin resistance.18091752
Diabetes MellitusDeregulated Nutrient SensingEvidence shows that even a slight reduction in body mass may improve carbohydrate tolerance, lipid profile and insulin resistance, reduce insulin levels and finally delay or reduce risk of diabetes mellitus.18159849
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance accompanies hyperinsulinemia, a major indicator of insulin resistance.18159849
Histiocytosis, Langerhans-Cell, HypopituitarismDeregulated Nutrient SensingHowever, the insulin resistance index GIR was decreased in patients with LCH without anterior pituitary deficiency compared to controls (P = 0.033).18160417
Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingIn vivo elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor.18160637
Fibrosis Assessment, Hepatitis CDeregulated Nutrient SensingInsulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis.18164296
Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Hepatitis CDeregulated Nutrient SensingOur study was designed to test the association between insulin resistance (IR) and hepatitis C virus (HCV) genotypes, serum HCV RNA level and liver fibrosis stage in a large prospective cohort of chronic hepatitis C (CHC) patients.18164296
Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingThis study investigated the relationship between oxidative stress, insulin resistance, steatosis and fibrosis in CHC.18164507
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingIgG against malondialdehyde-albumin adducts and HOMA-IR were measured as markers of oxidative stress and insulin resistance, respectively, in 107 consecutive CHC patients.18164507
Fatty degenerationDeregulated Nutrient SensingInsulin resistance and steatosis were evident in 80% and 70% of the patients, respectively.18164507
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingIn patients infected by HCV genotype non-3, oxidative stress and insulin resistance contribute to steatosis, which in turn exacerbates both insulin resistance and oxidative stress and accelerates the progression of fibrosis.18164507
HyperlipidemiaDeregulated Nutrient SensingInsulin resistance and oxidative stress in familial combined hyperlipidemia.18164710
Hyperlipidemia, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingFamilial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress.18164710
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCalpain-10 (CAPN10) has been identified as a susceptibility gene in type 2 diabetes mellitus (T2DM) and insulin resistance.18167206
Increased insulin level, Saint Lucia, Liver CirrhosisDeregulated Nutrient SensingLiver cirrhosis (LC) is characterized by an elevated number of circulating proinflammatory cytokines, hyperinsulinemia and insulin resistance.18171344
Obesity, Abdominal, Colonic adenomasDeregulated Nutrient Sensing[Abdominal obesity, insulin resistance, and the risk of colonic adenoma].18172342
Increased insulin level, Carcinogenesis, Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity and hyperinsulinemia or insulin resistance are of interest in connection with colon carcinogenesis.18172342
Colonic adenomasDeregulated Nutrient SensingHowever, insulin resistance was not related to colonic adenoma.18172342
Hypertensive disease, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSingle-pill amlodipine/atorvastatin therapy was well tolerated and effectively targeted HTN and dyslipidemia in this population of African Americans who were at risk of cardiovascular disease.18174006
Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingSIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.18174544
ARCN1 geneDeregulated Nutrient SensingTo determine the expression of SIRT1 in lungs of smokers and patients with COPD, and to elucidate the regulation of SIRT1 in response to cigarette smoke in macrophages, and its impact on nuclear factor (NF)-kappaB regulation.18174544
ARCN1 geneDeregulated Nutrient SensingPeripheral lungs of smokers and patients with COPD showed decreased levels of nuclear SIRT1, as compared with nonsmokers, associated with its post-translational modifications (formation of nitrotyrosine and aldehyde carbonyl adducts).18174544
ARCN1 geneDeregulated Nutrient SensingSIRT1 levels were reduced in macrophages and lungs of smokers and patients with COPD due to its post-translational modifications by cigarette smoke-derived reactive components, leading to increased acetylation of RelA/p65.18174544
ARCN1 geneDeregulated Nutrient SensingThus, SIRT1 plays a pivotal role in regulation of NF-kappaB-dependent proinflammatory mediators in lungs of smokers and patients with COPD.18174544
Endothelial dysfunction, diabeticDeregulated Nutrient SensingAdvanced endothelial dysfunction in diabetic patients with multiple risk factors; importance of insulin resistance.18174660
diabeticDeregulated Nutrient SensingThe present study was undertaken to determine whether the accumulation of cardiovascular risk factors and insulin resistance are associated with endothelial function in diabetic patients.18174660
Endothelial dysfunction, diabeticDeregulated Nutrient SensingThe present results suggest that the accumulation of cardiovascular risk factors is associated with endothelial dysfunction in diabetic patients, and that insulin resistance as well as high blood pressure could play a pathogenic role in the development of endothelial dysfunction.18174660
Carotid Intima-Media Thickness, Dyslipidemias, macroangiopathy, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing101 patients with type 2 diabetes without macroangiopathy stratified by the number of cardiovascular risk factors (dyslipidemia, hypertension, obesity) and 9 normal control subjects were studied for vascular endothelial functions by measuring flow-mediated vasodilation (FMD) using a high-resolution ultrasound method, brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT), and the ankle-brachial index (ABI).18174660
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is a risk factor for cardiovascular disease.18174771
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingWe also evaluated the presence of the insulin-resistance hepatic iron overload and of non-alcoholic fatty liver disease.18177470
Anxiety, CTCAE 3.0, AtherosclerosisDeregulated Nutrient SensingAssociations between trait anxiety, insulin resistance, and atherosclerosis in the elderly: a pilot cross-sectional study.18178323
Atherosclerotic lesionDeregulated Nutrient SensingRecent evidence is accumulating to show that insulin resistance (IR) plays a central role in determining the clinical manifestations of established atherosclerotic lesions.18178323
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingGenome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.18179892
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingIn vitro gene expression analysis in human coronary endothelial cells revealed that resistin induced fatty acid binding protein, a key molecule of insulin resistance, diabetes, and atherosclerosis.18180399
Decreased HDL cholesterol concentration, Diastolic hypertensionDeregulated Nutrient SensingIn longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all P < 0.05).18180784
Increase in blood pressureDeregulated Nutrient SensingLarger decreases in adiponectin over the menopause transition were associated with greater increases in systolic blood pressure, insulin and insulin resistance and with greater decreases in HDL-c.18180784
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCommon cardiovascular risk factors were: arterial hypertension (66.7%), dyslipidemia (58.9%), diabetes (42.9%), and smoking (27.4%).18187280
Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity is a major risk factor for insulin resistance and type 2 diabetes mellitus (T2DM).18188531
Alzheimers Disease", Data types - Address, Diabetes Mellitus, Apolipoprotein E4, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is a risk factor for late-onset Alzheimer's disease (AD), and studies suggest that pathogenic effects of diabetes and insulin resistance may be associated with non-APOE4 AD.18189240
Diabetes Mellitus, Data types - Address, Overweight, ObesityDeregulated Nutrient SensingWe also examined for interactions involving weight status as overweight and obesity are independent risk factors for insulin resistance, diabetes and AD.18189240
ObesityDeregulated Nutrient SensingThe inverse correlation between adiponectin and insulin resistance may manifest in the later phase of obesity development.18191043
Hypertensive (finding)Deregulated Nutrient SensingIndividuals with two hypertensive parents had high insulin, insulin resistance and low-density lipoprotein cholesterol.18192842
palladium, Pancreatic carcinomaDeregulated Nutrient SensingBefore the PD, the insulin curve suggested the presence of insulin resistance in pancreatic cancer patients, which was not observed after the operation.18192877
HyperinsulinismDeregulated Nutrient SensingWe report that rs2918419 was linked with hyperinsulinaemia and insulin resistance in men.18194492
Polycystic Ovary SyndromeDeregulated Nutrient SensingAlthough elevated levels of serum triglycerides are well documented with use of this drug, to the best of our knowledge this is the first report of a patient in whom polycystic ovary syndrome, a condition known to be associated with insulin resistance, manifested during isotretinoin therapy.18194936
Hyperglycemia, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe main outcome measures were prevalence of dyslipidemia, hyperglycemia, and hypertension; self-reported health status; and health care expenditures.18195001
Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity in older women: potential role for disrupted fatty acid reesterification in insulin resistance.18198225
Nonesterified Fatty Acids Measurement, Obesity, AbdominalDeregulated Nutrient SensingOur objectives were to examine the role of abdominal obesity on adipose tissue, hepatic, and peripheral insulin resistance in aging, and to examine impaired free fatty acid metabolism as a mechanism in these relations.18198225
Hypertriglyceridemia, NeoplasmsDeregulated Nutrient SensingIt was suggested that hypertriglyceridemia was brought about by early-onset insulin resistance in fat tissue prior to development of tumors.18198613
Amyotrophic Lateral Sclerosis, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is a protective factor in amyotrophic lateral sclerosis.18199832
NeoplasmsDeregulated Nutrient SensingMammalian Sir2 (SIRT1) has also been found to regulate premature cellular senescence induced by the tumor suppressors PML and p53.18203716
CarcinogenesisDeregulated Nutrient SensingThe sirtuins and silent information regulator 1 (SIRT1) in particular, are known to play a role in the response to DNA damage, metabolism, longevity and carcinogenesis.18204789
levothyroxineDeregulated Nutrient SensingIn this context, we identified L-thyroxin, insulin and sodium nitroprusside to be potent activators of human SIRT1 expression.18204789
levothyroxineDeregulated Nutrient SensingIn addition, treatment of PBMCs with sodium nitroprusside was associated with a significant cellular lifespan extension, while L-thyroxin and insulin were unable to prolong lifespan, suggesting that isolated upregulation of SIRT1 is in fact insufficient to promote longevity.18204789
ObesityDeregulated Nutrient SensingTo measure plasma ghrelin levels in children and adolescents, analyze the associated factors, and investigate the role of ghrelin in obesity, insulin resistance and reproductive physiology.18205273
Hypertension, CTCAE, Stricture of artery, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension, dyslipidemia and diabetes were risk factors for the development of intracranial arterial stenosis.18206033
Refractory anemias, Dyslipidemias, Comorbidity, Angina PectorisDeregulated Nutrient SensingA comorbidity of dyslipidemia, prior angina, percutaneous coronary intervention (PCI) within 6 months was more common in patients with RA, P < 0.05.18208658
Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Degenerative polyarthritis, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient Sensing172 sedentary older adults with overweight or obesity, type 2 diabetes, hypertension, dyslipidemia, or osteoarthritis were enrolled in a randomized controlled trial with a 3-month follow-up.18209255
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingPatients with Stage D HF are frequently males with dyslipidemia and coronary artery disease.18215606
GDC Comorbidity Terminology, Dyslipidemias, Arthritis, Psoriatic, Hypertension, CTCAEDeregulated Nutrient SensingPreexisting comorbid conditions included psoriatic arthropathy (13%), dyslipidemia (14.1%) and hypertension (20.2%).18216476
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe relationship between dyslipidaemia and cardiovascular disease is well documented.18218195
Lupus ErythematosusDeregulated Nutrient SensingType B insulin resistance syndrome induced by increased activity of systemic lupus erythematosus in a hemodialysis patient.18218307
Lupus Erythematosus, SystemicDeregulated Nutrient SensingThe presented patient developed a Type B insulin resistance syndrome induced by increased activity of SLE after she had been treated with hemodialysis for 5 years.18218307
Hypoglycemia, Lupus Erythematosus, SystemicDeregulated Nutrient SensingType B insulin resistance syndrome must be considered in the differential diagnosis of hypoglycemia in SLE patients on dialysis.18218307
Proteinuria, Kidney FailureDeregulated Nutrient SensingImpact of age, body mass index, insulin resistance and proteinuria on the kidney function in obese patients with Type 2 diabetes and renal insufficiency.18218312
DyslipidemiasDeregulated Nutrient SensingComplications of dyslipidemia increase the risk, but direct evidence is limited, so a cohort prospective study (Japan-CDM) was conducted.18219157
Hypercholesterolemia, Arteriosclerosis, Dyslipidemias, OsteoporosisDeregulated Nutrient SensingOsteoporosis has been linked with arteriosclerotic vascular diseases, suggesting that hypercholesterolemia or dyslipidemia may be a common pathogenetic factor underlying these diseases.18219179
Hypercholesterolemia, Dyslipidemias, FractureDeregulated Nutrient SensingThese results indicate increased bone turnover in hypercholesterolemic or dyslipidemic patients regardless of gender, and suggest the importance of treating hypercholesterolemia or dyslipidemia in order to prevent not only arteriosclerotic complications but also osteoporotic bone loss and subsequent fractures.18219179
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo establish the frequency of dyslipidemia in obese Israeli children and adolescents and its association with other cardiovascular disease (CVD) risk factors.18219218
Coronary heart disease, Diabetes MellitusDeregulated Nutrient Sensing[Effects of a superselective beta1-adrenoblocker nebivolol on the course of coronary heart disease and insulin resistance in patients with diabetes mellitus type 2 after coronary artery bypass grafting].18220029
Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo study safety and effects of nebivolol on the course of coronary heart disease (CHD) and insulin resistance (IR) in patients with diabetes mellitus type 2 (DM-2) after coronary artery bypass grafting.18220029
DyslipidemiasDeregulated Nutrient SensingThis lowered the risk of effects of diabetic atherogenic dyslipidemia.18220029
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is prevalent in children with type 1 diabetes mellitus (T1DM), with an association between elevated hemoglobin A1c (HbA1c), serum lipid levels, and oxidative stress.18221422
Beta-Cell Function MeasurementDeregulated Nutrient SensingInsulin resistance fell once normal thyroid function was restored and helped to attenuate further beta-cell destruction when beta-cell mass was relatively well preserved.18221436
Weight decreasedDeregulated Nutrient SensingMetformin, without weight loss or increased physical activity, resulted in restoration of menstrual cycle, reduction in serum T, and improvement in insulin resistance (IR).18222436
Weight GainDeregulated Nutrient SensingHigh birth weight and early postnatal weight gain protect obese children and adolescents from truncal adiposity and insulin resistance: metabolically healthy but obese subjects?18223033
Cardiovascular DiseasesDeregulated Nutrient SensingLow birth weight (LBW), no early catch-up weight, and subsequent fat accumulation have been associated with increased risks of insulin resistance from childhood onward and later cardiovascular disease.18223033
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAfter adjusting for these variables, multivariate analysis showed weight increase, waist-to-hip ratio and the indices of insulin resistance and beta-cell function were significantly associated with the risk for type 2 diabetes.18226046
Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIt has been demonstrated that parents and brothers of PCOS women exhibit insulin resistance and related metabolic defects.18230657
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingIn addition, insulin resistance became evident as the subjects got older, which may place them at risk for the development of type 2 diabetes and cardiovascular disease.18230657
Metabolic DiseasesDeregulated Nutrient SensingVisfatin and lipocalin-2 are novel adipokines associated with insulin resistance (IR) and obesity-related metabolic disorders.18230827
Fatty LiverDeregulated Nutrient SensingAre saturated fatty acids and insulin resistance associated with fatty liver in obese children?18234396
ObesityDeregulated Nutrient SensingObesity and insulin resistance (IR) play an important role in pathogenesis of FL.18234396
Inflammation, Endothelial dysfunctionDeregulated Nutrient SensingBoth biomarkers of endothelial dysfunction correlated significantly with markers of inflammation (interleukin-6 [IL-6] and C-reactive protein [CRP]), hepatic function (gamma-glutamyl transferase [GGT]), and insulin resistance, with t-PA showing stronger associations with adiposity, hepatic function, and insulin resistance than vWF.18235054
Hepatitis CDeregulated Nutrient SensingProspective study of liver transplant recipients with HCV infection: evidence for a causal relationship between HCV and insulin resistance.18236394
Communicable Diseases, Hepatitis CDeregulated Nutrient SensingAn association between hepatitis C virus (HCV) infection and insulin resistance (IR) has been recently reported.18236394
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingGenotyping for beta(1)Ser49Gly polymorphism in type II diabetic patients may have clinical benefit to predict obesity, thereby contributing to the prevention of insulin resistance.18239290
Smoking Status, Obesity, Visceral, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAnalysis of covariance showed that interaction between BMI and visceral obesity (f=7.202, p=0.007) was significantly associated with IMT, in addition to age, visceral obesity, smoking status, hypertension, dyslipidemia and uric acid.18239322
Diastolic dysfunction, Hypertensive (finding)Deregulated Nutrient SensingDiastolic dysfunction is associated with insulin resistance, but not with aldosterone level in normotensive offspring of hypertensive families.18239385
ObesityDeregulated Nutrient SensingResistin is thought to be involved in the development of obesity and insulin resistance.18239575
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHeart transplant recipients often suffer from obesity, dyslipidemia, and hypertension thought to be related to triple-drug immunosuppression and poor adherence to diet and exercise.18240698
Hepatobiliary Disorder, DyslipidemiasDeregulated Nutrient SensingTherefore variations in the plasma lipid profile due to primary (genetic) or secondary (environmental) dyslipidemia could affect the development of liver disease.18241317
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR), or low insulin sensitivity, is a major risk factor in the pathogenesis of type 2 diabetes and cardiovascular disease.18242418
ObesityDeregulated Nutrient SensingThe anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra) is the most highly elevated known cytokine in human obesity, and its serum levels are strongly associated with the degree of insulin resistance in non-diabetic patients.18243027
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe increased load on the pancreas from insulin resistance induced by chronically short sleep durations can, over time, compromise beta-cell function and lead to type 2 diabetes.18246976
ARCN1 gene, Primary malignant neoplasm, Demographics Domain, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Heart failureDeregulated Nutrient SensingData were collected on sociodemographic variables, Barthel index, Lawton index), Minimental State Examination, total number of drugs, history of high blood pressure (HBP), diabetes mellitus (DM), dyslipidemia (DL), heart failure (HF), chronic obstructive pulmonary disease (COPD) and cancer.18247277
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingStaged diabetes management according to individual patient insulin resistance and beta-cell function ameliorates glycaemic control in type 2 diabetes mellitus.18248646
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe new SDM strategy, based on individual data on insulin resistance and insulin secretion, may provide valuable clinical benefits in non-obese Korean patients with type 2 diabetes.18248646
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAmong MS-positive subjects, insulin resistance ranged from 94.8% (EGIR) to 49.2% (IDF), whereas type 2 diabetes mellitus (excluded by EGIR and AACE criteria) rated 59.9% by World Health Organization and 22% to 24% by ATP III, IDF, or American Heart Association/National Heart, Lung, and Blood Institute.18249207
Glucose Intolerance (disease), HyperuricemiaDeregulated Nutrient SensingBoth NCEP- and IDF-MS were associated with glucose intolerance and hyperuricemia.18250613
ObesityDeregulated Nutrient Sensing[Study on the relationships of childhood obesity and the duration of sleep as well as insulin resistance].18251279
Dyslipidemias, Mental disorders, Diabetes MellitusDeregulated Nutrient SensingIncreased risk of diabetes and dyslipidemia is associated with major mental illness and antipsychotic drug use.18251625
Diabetes MellitusDeregulated Nutrient SensingOur findings provide a mechanistic explanation for the involvement of these genetic variations in the development of insulin resistance and type 2 diabetes.18252792
Inflammation, ETV3 wt AlleleDeregulated Nutrient SensingOur findings suggest that higher circulating adiponectin levels may mitigate against adipose-related inflammation, insulin resistance and MetS as much in lean as obese persons.18253163
Deficiency of butyryl-CoA dehydrogenase, Hypertensive (finding), Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingSCAD was significantly more prevalent in patients aged > or = 60 (13.2%, vs 6.25%; p < .001), in symptomatic patients (16.45% vs 6.32%; p < .001), in diabetics (15.96% vs 7.39%; p < .001), in patients with ischemic heart disease (17.65% vs 7.22%; p < .001), in hypertensive patients (12% vs 7.54%; p = .025), and in patients with dyslipidemia (12.53% vs 6.56%; p < .025).18258161
Chronic Kidney DiseasesDeregulated Nutrient SensingGlucose metabolism, insulin resistance, and renal pathology in non-diabetic chronic kidney disease.18259103
AtherosclerosisDeregulated Nutrient SensingThe relation between insulin resistance and atherosclerosis is widely recognized, but it remains unknown whether glucose metabolism/insulin resistance is related to renal pathology in humans.18259103
Chronic Kidney DiseasesDeregulated Nutrient SensingAlthough precise mechanisms remain unknown, glucose metabolism/insulin resistance seem to play pathogenic roles in formation and progression of renal pathological changes, especially tubulointerstitial and vascular lesions, in non-diabetic CKD.18259103
DyslipidemiasDeregulated Nutrient SensingMore than 80% of symptomatic postmenopausal women had atherogenic dyslipidemias.18260873
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe latter stands as the basis upon which diabetes, hypertension, and atherogenic dyslipidemia tend to build up.18264836
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe reveal a previously unrecognized role for DGKdelta in contributing to hyperglycemia-induced peripheral insulin resistance and thereby exacerbating the severity of type 2 diabetes.18267070
PliabilityDeregulated Nutrient SensingDGKdelta deficiency causes peripheral insulin resistance and metabolic inflexibility.18267070
Obesity, Coronary heart diseaseDeregulated Nutrient SensingThe influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary disease.18268512
Hyperlipidemia, Congenital Abnormality, Coronary heart disease, Obesity, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAEDeregulated Nutrient SensingObesity promotes the development and progression of coronary heart disease (CHD), in part, through its association with hyperlipidemia, hypertension, clotting abnormalities and insulin resistance.18268512
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance is a hallmark of type 2 diabetes and commonly observed in other energy-stressed settings such as obesity, starvation, inactivity and ageing.18269172
Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingIn the Insulin Resistance and Atherosclerosis Study (IRAS), we have previously shown a protective effect of plasma alpha-tocopherol concentration against diabetes incidence among persons not taking vitamin E supplements.18269637
Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, daytime sleepiness, FatigueDeregulated Nutrient SensingFatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance.18270241
Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, Daytime somnolence, FatigueDeregulated Nutrient SensingFatigue in NAFLD appears to be unrelated to either severity of underlying liver disease or insulin resistance, but is associated with significant daytime somnolence.18270241
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, HyperandrogenismDeregulated Nutrient SensingHyperandrogenia and insulin resistance are heritable family traits, likely to cluster in children of polycystic ovary syndrome (PCOS) mothers.18270257
AtherosclerosisDeregulated Nutrient SensingA slight but significant increase in prolonged insulin secretion, which is associated with the early stage of insulin resistance, in subjects with NGT, may play an important role in the pathogenesis of atherosclerosis.18270458
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA low plasma HDL-C level is characteristic of atherogenic dyslipidemia in patients with type 2 diabetes.18270459
Metabolic Syndrome XDeregulated Nutrient SensingIdentifying metabolic syndrome patients may direct therapy focusing on treatment of insulin resistance by reducing weight and increasing physical activity.18273039
AtherosclerosisDeregulated Nutrient SensingInsulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation.18273540
Dyslipidemias, diabeticDeregulated Nutrient SensingThe baseline prevalence of high blood pressure and dyslipidemia is higher in diabetic patients (70.4% vs. 54% and 73.2% vs. 50.6%, respectively).18275764
Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSeveral PCOS women present abdominal adiposity (visceral fat) with a level of peripheral insulin resistance (IR), similar to that present in women with type 2 diabetes, in association with an increased incidence of impaired glucose tolerance.18277351
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingAssociation of hypertensive diastolic blood pressure with dyslipidemia during exercise in apparently healthy subjects.18277829
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingConcurrent hypertension and dyslipidaemia in THIN increased from 5.5% (1.1%) in 1998 to 13.5% (4.5%) in 2003 and 17.4% (7.1%) in 2006.18279464
Dyslipidemias, Chronic Kidney Diseases, Coronary heart diseaseDeregulated Nutrient SensingWe assessed sociodemographic and clinical data, cardiovascular risk factors, coronary disease risk categories, dyslipidemia characteristics, functional CKD stage, and pharmacological treatments.18279629
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMetformin improved glycemic control and reduced insulin resistance in obese type 2 diabetes mellitus patients.18280440
HyperglycemiaDeregulated Nutrient SensingInitial insulin therapy led to rapid reduction in hyperglycemia with reduced insulin resistance.18280440
Colorectal, Increased insulin level, AcromegalyDeregulated Nutrient SensingIs there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly?18283256
Colorectal, AcromegalyDeregulated Nutrient SensingTo evaluate a relation between insulin level, insulin resistance and its anthropometric markers and colorectal lesions in patients with acromegaly.18283256
Increased insulin level, Acromegaly, PathologyDeregulated Nutrient SensingThe study results show a relation between hyperinsulinemia, insulin resistance and colon pathologies in acromegaly.18283256
Kidney Failure, Chronic, InflammationDeregulated Nutrient SensingThe cornerstone of high CVD incidence in ESRD patients is endothelial dysfunction which results from inflammation, oxidative stress and insulin resistance.18285698
HD Term TypeDeregulated Nutrient SensingFor patients receiving HD, the high-flux dialyzer with synthetic polysulfone membranes fails to provide a better anti-inflammatory or antioxidative effect than the low-flux dialyzer; however, the high-flux dialyzer does significantly improve insulin resistance in this short-term study.18285698
Fatty LiverDeregulated Nutrient SensingLow hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans.18286258
ObesityDeregulated Nutrient SensingOur data suggest that high hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity.18286258
Hepatitis C, Chronic, Hepatitis C, Hepatitis B, Diabetes MellitusDeregulated Nutrient SensingPrevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients.18290778
Renal Insufficiency, Dyslipidemias, Diabetes Mellitus, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingBaseline differences in demography, cardiovascular risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia, renal impairment), and severity of peripheral arterial disease (ankle-brachial indices, TcPO(2), prior arterial reconstruction) were not significant.18295105
ObesityDeregulated Nutrient SensingOverweight or obesity and insulin resistance were prevalent.18300117
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCAD risk factors were hypertension (53%), dyslipidemia (48%), smoking (34%) and diabetes (34%).18301868
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDespite associations with total adiponectin and insulin resistance, our data go against any apparent association between HMW adiponectin levels and incident CHD events.18303082
HyperglycemiaDeregulated Nutrient SensingInsulin resistance, hyperglycaemia, diastolic blood pressure and MMP-9 levels were also reduced (P < 0.017).18307460
Prostate carcinoma, ObesityDeregulated Nutrient SensingAdipocytokines, obesity, and insulin resistance during combined androgen blockade for prostate cancer.18308111
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidaemia as a predictor of hypertension in middle-aged men.18308688
AtherosclerosisDeregulated Nutrient SensingThe independent contribution of insulin resistance to atherosclerosis is still under debate.18309150
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingOverweight, elevated waist circumference, hypertension, and dyslipidemia were more prevalent in the city.18310309
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMetabolic risk factors, insulin-resistance and lifestyle in children of type 2 diabetes patients in Karachi, Pakistan.18313164
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo assess metabolic risk factors, insulin-resistance and lifestyle in children aged 8-20 years of patients with type 2 diabetes and to compare these with children aged 8-20 years of non-diabetic subjects.18313164
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe presence of abdominal obesity and dyslipidemia in men and abdominal obesity in women revealed positive impacts on uric acid levels.18314213
Steatohepatitis, Non-alcoholic Fatty Liver Disease, HyperglycemiaDeregulated Nutrient SensingNonalcoholic fatty liver, affecting 34% of the U.S. population, is characterized by hepatic insulin resistance, which is more marked in the presence of steatohepatitis, and frequently precedes hyperglycemia.18316359
Fatty LiverDeregulated Nutrient SensingThe molecular mechanisms underlying the relationship between fatty liver and insulin resistance are still undergoing definition and have not been evaluated in humans.18316359
SteatohepatitisDeregulated Nutrient SensingFOXO1 expression and activity are increased in patients with steatohepatitis, and mRNA levels are correlated with hepatic insulin resistance.18316359
HIV, DyslipidemiasDeregulated Nutrient SensingTreatment of human immunodeficiency virus (HIV) with protease inhibitors (PIs) is associated with insulin resistance, triglyceride-rich dyslipidemia, and fat redistribution.18317438
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension was present in 77.8%, diabetes in 27.8% and dyslipidemia in 32.4%.18317619
Acute Coronary Syndrome, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingThe relationship between coronary artery disease (CAD) and dyslipidemia in acute coronary syndromes has been rarely demonstrated in clinical and epidemiological studies.18317637
Diabetes MellitusDeregulated Nutrient SensingLow testosterone levels are common and associated with insulin resistance in men with diabetes.18319314
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance.18319314
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes.18319314
ObesityDeregulated Nutrient SensingThus, TNF-alpha may contribute to the insulin resistance of overall obesity, whereas IL-6 may be one of the mediators of the hyperinsulinemic state specifically related to excess visceral adiposity.18319319
Hyperhomocysteinemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and hyperhomocysteinemia are independent risk factors for the occurrence of recurrent CRVO.18320516
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingPostprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance.18321693
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPostprandial lipoprotein abnormalities in type 2 diabetes are associated with insulin resistance.18321693
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue.18321693
AtherosclerosisDeregulated Nutrient SensingDesigned as a cross-sectional, epidemiologic study, the Insulin Resistance Atherosclerosis Study was conducted in four centers: San Antonio (Texas), San Luis Valley (Colorado), and Oakland and Los Angeles (California).18322051
Impaired cognition, Anemia, ObesityDeregulated Nutrient SensingIn the elderly, a combination of high folate levels and low vitamin B-12 status may be associated with an increased risk of cognitive impairment and anemia and, in pregnant women, with an increased risk of insulin resistance and obesity in their children.18326588
Cerebrovascular Disorders, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPopulation II was comprised of 158 subjects with or without either CAD or cerebro-vascular disease, and matched for age, sex, smoking status, weight category and the presence of hypertension, dyslipidemia, and diabetes.18327409
Dyslipidemias, Cardiovascular Diseases, diabeticDeregulated Nutrient SensingDyslipidemia is still under-treated despite the availability of effective pharmacological agents and the greatly increased risk of cardiovascular diseases in diabetic patients.18330400
Hypertension, CTCAE, Psoriasis, DyslipidemiasDeregulated Nutrient SensingDermatologists taking care of patients with psoriasis should be aware of this association and advise the patients to reduce additional risk factors such as smoking, hypertension or dyslipidemia.18331320
HyperglycemiaDeregulated Nutrient SensingPost-operative insulin resistance and hyperglycaemia are associated with an impaired outcome after surgery.18331374
HyperglycemiaDeregulated Nutrient SensingPre-operative oral carbohydrate loading (CHO) reduces post-operative insulin resistance with a reduced risk of hyperglycaemia during post-operative nutrition.18331374
Lipolysis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPeroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists such as thiazolidinediones (TZDs) improve insulin sensitivity in type 2 diabetes mellitus (T2DM) through effects on fat metabolism whereas GH stimulates lipolysis and induces insulin resistance.18331610
Turner Syndrome, Dyslipidemias, Obesity, Hypertension, CTCAE, Impaired T cell functionDeregulated Nutrient SensingThe primary pathogenic event is beta cell dysfunction, but insulin resistance also plays a central role and is worsened by the presence of hypertension, obesity and dyslipidemia which are common in Turner syndrome.18333365
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient Sensingblood pressure, dyslipidemia, diabetes, obesity, smoking, alcohol intake, physical activity and fruit and vegetable intake.18335048
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSome studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.18335327
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIndividuals with at least one risk factor of type 2 diabetes should have screening test to diagnose glucose intolerance.18335394
Dyslipidemias, Uterine FibroidsDeregulated Nutrient SensingTo analyze the possible association between insulin resistance and dyslipidemia with uterine fibroids, using objective metabolic measurements.18336822
Uterine FibroidsDeregulated Nutrient SensingInsulin resistance was not shown to be a risk factor for fibroids.18336822
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA single nucleotide polymorphism (S89N) in the gene encoding U-II (UTS2) is associated with the onset of Type 2 diabetes and insulin resistance in the Japanese population.18338983
Diabetes Mellitus, Insulin-Dependent, Glucose Intolerance (disease), Impaired healthDeregulated Nutrient SensingDevelopment of glucose metabolism impairment ranging from glucose intolerance to insulin-dependent diabetes is observed in the evolution of these patients.18339976
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe study purpose was to compare the prevalence of dyslipidemia between a self-reported survey, Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD), and survey and laboratory data from National Health and Nutrition Examination Survey (NHANES 1999-2002).18346311
TG gene, DyslipidemiasDeregulated Nutrient SensingComponents of dyslipidemia were uniformly less in SHIELD than NHANES: high TC = 17 vs. 35%, high LDL-C = 10 vs. 14%, high TG = 7 vs. 17% and low HDL-C = 5 vs. 24%; all comparisons p < 0.01.18346311
TG gene, DyslipidemiasDeregulated Nutrient SensingDyslipidemia prevalence was lower in self-reported SHIELD than the objectively assessed NHANES, with especially low self-report of high TG and low HDL-C. Self-reported prevalence of dyslipidemia may under-report the prevalence based on laboratory data.18346311
HD Term Type, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingUnfortunately, growing number of type 2 diabetic hemodialysis (HD) patients with insulin resistance are now being diagnosed in Japan.18346811
Childhood onset fluency disorderDeregulated Nutrient SensingThe effects of childhood-onset diabetes and insulin resistance in nondiabetic individuals on SHBG and testosterone in children and young adults are poorly understood.18346991
Diabetes MellitusDeregulated Nutrient SensingIn those without diabetes, greater insulin resistance had a small, nonsignificant association with lower SHBG and higher free testosterone.18346991
Pulmonary Emphysema, CachexiaDeregulated Nutrient SensingPulmonary emphysema is associated with cachexia and disregulation of the hormones regulating the glycolipid metabolism, insulin resistance, and altered substrate utilization.18347203
Stanford Cancer InstituteDeregulated Nutrient SensingThe increased levels of IMCL might interfere with the glucose uptake in skeletal muscle; potentially predisposing persons with incomplete SCI to the development of peripheral insulin resistance.18347608
Hyperhomocysteinemia, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingHowever, these patients did demonstrate risk factors such as dyslipidemia and hyperhomocysteinemia for the development of atherosclerosis.18348424
AcromegalyDeregulated Nutrient SensingIMAT is greater in acromegaly, a novel finding, which suggests that increased AT in muscle could be associated with GH-induced insulin resistance.18349062
Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingLittle is known about the association of endothelial nitric oxide synthase (NOS3) gene polymorphisms and the presence of insulin resistance and the early evolution of atherosclerosis in nondiabetic subjects with cardiovascular disease (CAD) and stent implantation.18349107
Weight decreasedDeregulated Nutrient SensingWeight loss of 3-7% body weight yielded greater decreases in 2-h glucose (P < 0.01), insulin concentration (P < 0.04), and insulin resistance (P < 0.03) in men than in women.18356403
Edema, Dyslipidemias, Disorder of macula due to diabetes mellitusDeregulated Nutrient SensingAssociation of dyslipidaemia with macular oedema and hard exudates in diabetic maculopathy.18356786
Dyslipidemias, diabeticDeregulated Nutrient SensingIt has been observed that the appearance of hard exudates is consistent with the appearance of dyslipidaemia, which is typical for diabetic patients.18356786
Obesity, VisceralDeregulated Nutrient SensingContribution of the lean body mass to insulin resistance in postmenopausal women with visceral obesity: a Monet study.18356851
Ventricular FibrillationDeregulated Nutrient SensingThe contribution of VF to insulin resistance seems to be exacerbated by increased LBM in PM women.18356851
Renal Insufficiency, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is believed to be associated with the development of renal dysfunction.18359317
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingIt is well known that obesity and insulin resistance are closely related to the development of type 2 diabetes.18360022
Kidney DiseasesDeregulated Nutrient SensingHowever, the exact pathogenic mechanism underlying the insulin resistance in renal disease has not been clarified.18360022
HD Term TypeDeregulated Nutrient SensingIn conclusion, insulin resistance and CRP were related to fat-related parameters such as BMI, VFA and SFA in HD patients.18360022
Dyslipidemias, HaitiDeregulated Nutrient SensingAlthough the prevalences of all of the disorders showed significant progression from the sustained NT group towards the WCH and HT groups, the prevalence of dyslipidemia was significantly higher in the WCH group (P < 0.05 for all).18360067
Demographics Domain, Atherosclerosis, Dyslipidemias, Haiti, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDue to the gradually increased prevalences of obesity, IGT or DM, and CHD from the sustained NT group towards the WCH and HT groups and the highest prevalence of dyslipidemia in the WCH group, WCH should preferentially be accepted as an alarming sign of a deterioration in health rather than being a predisposing factor of HT or atherosclerosis alone.18360067
Dyslipidemias, Obesity, HaitiDeregulated Nutrient SensingThe significantly higher prevalence of dyslipidemia in the WCH group than in the HT group may be explained by the increased amount of adipose tissue in the HT cases, since the prevalence of obesity was the highest in the HT group.18360067
Weight Gain, Dyslipidemias, ObesityDeregulated Nutrient SensingThus, the high prevalence of WCH even in early decades may represent increased susceptibility to future weight gain, and dyslipidemia in patients with WCH may be a preliminary sign of obesity.18360067
Weight Gain, DyslipidemiasDeregulated Nutrient SensingTherefore, the management of WCH should focus on the prevention of dyslipidemia and excess weight gain.18360067
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingDeterminants of poor LDL cholesterol control were no lipid-lowering treatment, no previous diagnosis of ischemic heart disease, no antihypertensive treatment, and dyslipidemia.18361907
Dyslipidemias, GDC Disease Response TerminologyDeregulated Nutrient SensingClinical studies suggest that dyslipidemia is associated with the initiation and progression of DR.18362112
AcromegalyDeregulated Nutrient SensingWe therefore studied intra-abdominal fat and insulin resistance in acromegalic patients after a 3-month octreotide-washout period, i.e., during untreated acromegaly, and during PEG treatment.18362292
Lipolysis, Acromegaly, Glucose Intolerance (disease)Deregulated Nutrient SensingAcromegalic patients have increased lipolysis and decreased fat mass as well as reduced insulin sensitivity and glucose intolerance.18362292
AtherosclerosisDeregulated Nutrient SensingBACKGROUND Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved mainly in adipocyte differentiation and has been suggested to play an important role in the pathogenesis of insulin resistance (IR) and atherosclerosis.18362424
Sleep Apnea, CTCAE, Sleep Apnea, Obstructive, ObesityDeregulated Nutrient SensingAssociation of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea.18365276
Sleep Apnea, CTCAEDeregulated Nutrient SensingThe aim of the study was to investigate the association of sleep apnea severity with insulin resistance, leptin, and CRP levels in a cohort of male patients.18365276
Sleep Apnea, Obstructive, Sleep Apnea, CTCAE, ObesityDeregulated Nutrient SensingInsulin resistance estimated by the HOMA method in male patients with OSAS was not associated with sleep apnea severity independent of obesity.18365276
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThere is evidence that dyslipidemia is associated with chronic kidney disease (CKD).18366658
Dyslipidemias, Obesity, VisceralDeregulated Nutrient SensingMoreover, the genotype 877C/T contributed to both dyslipidemia and high FPG independent of age, sex, and visceral obesity.18370833
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes, male gender, and waist circumference were positively associated with a high ABI, and smoking and dyslipidemia were inversely associated with a high ABI.18371562
Albuminuria, Dyslipidemias, Diabetes Mellitus, Renal Insufficiency, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of albuminuria and renal dysfunction on development of dyslipidaemia in type 2 diabetes--the Hong Kong Diabetes Registry.18372388
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA prospective cohort of 2761 type 2 diabetic patients without significant dyslipidaemia and having at least one measurement of TC, LDL-C and HDL-C during 2.8 years of follow-up was analysed.18372388
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance frequently occurs in non-diabetic patients with cardiovascular disease.18374336
Biliary calculi, Biliary Tract Cancer, ObesityDeregulated Nutrient SensingObesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary cancer.18375961
Inflammation, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe association between obesity and hypertension was positive and direct (B=0.43, p<0.01) without the intermediation of inflammation or insulin resistance.18378435
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOur study has demonstrated that obesity plays the central role in leading to hypertension and a pro-inflammatory state, insulin resistance and dyslipidaemia.18378435
Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingElevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD).18381580
Somatotropin deficiencyDeregulated Nutrient SensingLow-dose GH replacement in women with GHD decreased total and visceral adipose tissue and improved cardiovascular markers, with a relatively modest increase in IGF-1 levels and without worsening insulin resistance.18381581
ObesityDeregulated Nutrient SensingObesity, particularly central obesity, is considered as a systemic inflammatory condition and is related strongly to insulin resistance.18383516
Malignant neoplasm of endometriumDeregulated Nutrient SensingThe current results suggested that, in the Chinese population that was studied, obesity-related insulin resistance and proinflammatory effects may play an important role in endometrial cancer risk, and these effects were modified significantly by the CRP SNP rs1130864.18383516
Dyslipidemias, diabeticDeregulated Nutrient SensingDyslipidemia was documented in 50% of diabetic patients.18383562
Metabolic Syndrome X, ObesityDeregulated Nutrient SensingDuring this time, obesity, insulin resistance and the metabolic syndrome have also increased in prevalence.18384705
Dyslipidemias, atherosclerotic, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingTwenty five patients (67%) had other atherosclerotic risk factors such as smoking, dyslipidemia, hypertension and diabetes.18386616
Thrombus, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingBoth the thrombotic risk and the probability of stenosis detection were augmented by additional risk factors such as smoking, hypertension and dyslipidemia.18386616
Impaired T cell functionDeregulated Nutrient SensingWe have demonstrated in the present study the predominant role of beta cell dysfunction as compared to that of insulin resistance in the deterioration of glucose tolerance in non-obese women.18389389
Dyslipidemias, Myocardial Infarction, Cerebrovascular accident, Heart Diseases, Diabetes Mellitus, Obesity, OverweightDeregulated Nutrient SensingFamilial antecedents with risk for AHT were assessed: EAHT (36.7%), ischemic cardiopathy (13.3%), myocardial infarct (13.7%), stroke (15%), diabetes mellitus (13.2%), obesity (27.5%), and dyslipidemia (31.8%), as well as body mass index (BMI)--34.9% overweight persons and 32.9% suffering from obesity; repartition on blood groups, behaviour type (A--67.8%), sedentary lifestyle (35.8%), stress (extra-familial--32.1%), active tobacco smoking (52.1%), excess coffee (> 3 cup daily--35.7%), alcohol (10.1%) and salt (31.0%) consumption.18389797
Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe major medical history was hypertension (74.9%), followed by dyslipidemia (54.4%), diabetes mellitus (26.6%), and ischemic heart disease (18.0%).18389988
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and its co-morbidities are often present in patients with NAFLD.18390575
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingAtherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease.18390868
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAdiponectin is closely related to atherogenic dyslipidaemia and may be a clinical important mediator of recurrent coronary heart disease (CHD).18390868
DyslipidemiasDeregulated Nutrient SensingIn contrast, LDL-cholesterol and markers of atherogenic dyslipidaemia were independently associated with secondary CVD events (relative risk per unit increase: LDL-cholesterol: 1.54; 95%CI 1.18-2.01; P = 0.001, triglycerides: 1.58; 95%CI 1.31-1.90; P < 0.0001 and HDL-cholesterol: 0.34; 95%CI 0.14-0.79; P = 0.01).18390868
DyslipidemiasDeregulated Nutrient SensingIn contrast, approaching atherogenic dyslipidaemia may represent a promising target in secondary prevention programs for high-risk patients.18390868
Ischemic myocardial dysfunctionDeregulated Nutrient SensingMyocardial scar and insulin resistance predict cardiovascular events in severe ischaemic myocardial dysfunction: a perfusion-metabolism positron emission tomography study.18391729
Dyslipidemias, Diabetes Mellitus, Claudication (finding), CLU protein, human, Kidney FailureDeregulated Nutrient SensingWhile in the CLI group, patients were older, with higher rates of female sex, diabetes (62% vs. 48%, p<0.001) and severe renal failure, claudicants were significantly younger, with higher rates of smokers among men (75% vs. 51%, p<0.001) and moderate dyslipidemia (52% vs. 36%, p<0.001).18391869
ACSM3 gene, Dyslipidemias, Diabetes Mellitus, Musculoskeletal Pain, Acyl Carrier ProteinDeregulated Nutrient Sensingthe prevalence of CAD among RVHD patients is low, whereas it is high among NVHD patients; the rheumatic etiology does not seem to have any beneficial effects on the prevalence of CAD; gender, age, SAH, TACP, dyslipidemia and diabetes were identified as being strongly associated with the presence of CAD.18392400
Allergic sensitization, Asthma, ObesityDeregulated Nutrient SensingAssociation of obesity and insulin resistance with asthma and aeroallergen sensitization.18394132
Asthma, Obesity, Allergy - Charge Type ReasonDeregulated Nutrient SensingIt has been hypothesized that obesity and insulin resistance may play a role in the development of asthma and allergy.18394132
Allergic sensitization, Allergic asthma, Intrinsic asthmaDeregulated Nutrient SensingInsulin resistance was asssociated with aeroallergen sensitization and allergic asthma, but not nonallergic asthma.18394132
Allergic asthma, Obesity, Intrinsic asthmaDeregulated Nutrient SensingThe associations of obesity with aeroallegen sensitization and allergic asthma became nonsignificant after adjustment for insulin resistance, whereas the association of obesity with nonallergic asthma was unaffected.18394132
Allergic sensitization, Allergic asthma, ObesityDeregulated Nutrient SensingObesity may be related to an increased risk of aeroallergen sensitization and allergic asthma through mechanisms also involved in the development of insulin resistance.18394132
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance has been assigned a pivotal role in the pathological progression associated with type 2 diabetes and other chronic metabolic diseases.18395354
Non-alcoholic Fatty Liver Disease, HepatitisDeregulated Nutrient SensingInsulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase.18397231
Hepatitis CDeregulated Nutrient SensingRecent studies using transgenic mouse models have demonstrated that the presence of hepatitis C virus (HCV) singularly induces insulin resistance (IR).18397231
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, to date, the various associations between factors related to the course of type 2 diabetes, like metabolic compensation, beta cell secretory dysfunction, insulin resistance and IL-12 serum levels, remain unclear.18397831
AtherosclerosisDeregulated Nutrient SensingThis finding gives us hope that treatment to decrease peripheral insulin resistance and to avoid excessive proinsulin secretion might be successful in the prevention of IL-12-induced atherosclerosis.18397831
Hand muscle atrophyDeregulated Nutrient SensingUsing PABPN1 nematodes that show muscle cell degeneration and abnormal motility, we found that increased dosage of the sirtuin and deacetylase sir-2.1/SIRT1 exacerbated muscle pathology, an effect dependent on the transcription factor daf-16/FoxO and fuel sensor aak-2/AMPK (AMP-activated protein kinase), while null mutants of sir-2.1, daf-16 and aak-2 were protective.18397876
Muscular Dystrophy, OculopharyngealDeregulated Nutrient SensingAltogether, our data identify Sir2 and AMPK inhibition as therapeutic strategies for muscle protection in OPMD, extending the value of druggable proteins in cell maintenance networks to polyalanine diseases.18397876
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTreatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.18397984
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingIn vitro and in vivo studies have then showed its effects on hyperglycemia and dyslipidemia.18397984
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe objective of the study was to evaluate the efficacy and safety of berberine in the treatment of type 2 diabetic patients with dyslipidemia.18397984
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOne hundred sixteen patients with type 2 diabetes and dyslipidemia were randomly allocated to receive berberine (1.0 g daily) and the placebo for 3 months.18397984
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBerberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.18397984
Malnutrition, Chronic inflammation, Atherosclerosis, Dyslipidemias, Cessation of lifeDeregulated Nutrient SensingAtherosclerotic cardiovascular disease is the most common cause of death among hemodialysis patients; it has been attributed to increased oxidative stress, dyslipidemia, malnutrition, and chronic inflammation.18400731
Presenile dementia, Glucose Intolerance (disease), Impaired cognitionDeregulated Nutrient SensingImpaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.18401020
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Kidney Failure, Diabetes MellitusDeregulated Nutrient SensingIn particular patients having additional cardiac risk factors like diabetes mellitus, dyslipidemia, increased waist circumference as well as concomitant diseases like myocardial infarction, heart- as well as kidney failure would benefit from an effective antihypertensive therapy.18402243
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.18402781
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance.18402781
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThis parameter should be considered in addition to other well-known risk factors such as diabetes, hypertension, smoking, and dyslipidemia.18404269
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined whether reduction of both non-oxidative glucose disposal and glucose oxidation contributes to insulin resistance in type 2 diabetes.18410564
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn addition, exercise improves insulin resistance mainly by increasing non-oxidative glucose disposal in type 2 diabetes.18410564
Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTwo of four major cardiac risk factors (hypertension and diabetes) were recorded in 90% of patient records; however, arguably the most important reversible risk factors for cardiac disease (dyslipidemia and smoking) were only reported 80% of the time.18411042
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate the effects of extended-release metformin (MXR) compared with immediate-release metformin (MIR) on post-prandial glycaemic excursion, chronic glycaemia, lipid profiles, insulin resistance and islet function in type 2 diabetes.18412932
diabeticDeregulated Nutrient SensingDiabetic patients with poor glycemic control may be associated with neuronal dysfunction/damage in brain in accordance with A1C levels and, in some, extend with insulin resistance.18413166
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance following cardiothoracic surgery in patients with and without a preoperative diagnosis of type 2 diabetes during treatment with intravenous insulin therapy for postoperative hyperglycemia.18413197
Diabetes MellitusDeregulated Nutrient SensingTo assess insulin resistance postoperatively in patients with (DM) and without (nonDM) a prior diagnosis of diabetes.18413197
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAfter adjustments were made for age, race, ethnicity, and sex in the quasi-Poisson model, CCS was associated with hypertension, dyslipidemia, and diabetes (P < .001 for all diseases).18413889
Malignant tumor of colon, Neoplastic Cell TransformationDeregulated Nutrient SensingThe SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.18414679
Primary malignant neoplasmDeregulated Nutrient SensingThe Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals.18414679
Malignant tumor of colon, NeoplasmsDeregulated Nutrient SensingHere we show that CR induces a two-fold increase SIRT1 expression in the intestine of rodents and that ectopic induction of SIRT1 in a beta-catenin-driven mouse model of colon cancer significantly reduces tumor formation, proliferation, and animal morbidity in the absence of CR.18414679
Colonic NeoplasmsDeregulated Nutrient SensingConsistent with this, a significant inverse correlation was found between the presence of nuclear SIRT1 and the oncogenic form of beta-catenin in 81 human colon tumor specimens analyzed.18414679
Intestinal NeoplasmsDeregulated Nutrient SensingTaken together, these observations show that SIRT1 suppresses intestinal tumor formation in vivo and raise the prospect that therapies targeting SIRT1 may be of clinical use in beta-catenin-driven malignancies.18414679
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance improved in 38% of the 21 patients with diabetes mellitus.18415756
Coronary heart diseaseDeregulated Nutrient SensingCoronary heart disease likelihood, significantly associated with Lp(a) concentrations, is independent of MS and insulin resistance.18418227
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe objective of our study was to determine values of key lipid and lipoprotein fractions in PCOS, and their possible relation to insulin resistance.18418429
Prostate Cancer Outcomes Study, DyslipidemiasDeregulated Nutrient SensingPCOS patients compared with controls had increased indices of insulin resistance, basal insulin (p < 0.001), and HOMA index (p < 0.001), and worsened insulin resistance-related dyslipidemia with decreased HDL cholesterol (p < 0.01), elevated triglycerides (p = 0.010), and pronounced LDL oxidation (p < 0.001).18418429
Prostate Cancer Outcomes Study, DyslipidemiasDeregulated Nutrient SensingIn conclusion, characteristic dyslipidemia of insulin resistance and unfavorable proatherogenic lipoprotein ratios were present only in women with PCOS and not in controls.18418429
Prostate Cancer Outcomes Study, Precocious atherosclerosisDeregulated Nutrient SensingElevated OxLDL and the relation of apoE and nonesterified fatty acids with insulin resistance suggest that women with PCOS are at increased risk for premature atherosclerosis.18418429
InflammationDeregulated Nutrient SensingT-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance.18420999
InflammationDeregulated Nutrient SensingAdipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR).18420999
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingIn conclusion, FABP4 plasma concentrations hold strong potential for development as a clinical biomarker for atherogenic dyslipidemia, independent of obesity and insulin resistance, in type 2 diabetic subjects.18421072
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPlasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes.18421072
Dyslipidemias, diabeticDeregulated Nutrient SensingType 2 diabetic subjects were categorized according the presence of atherogenic dyslipidemia.18421072
DyslipidemiasDeregulated Nutrient SensingHigh FABP4 and low adiponectin levels are independent predictors of atherogenic dyslipidemia.18421072
Microalbuminuria, White matter lesions, diabeticDeregulated Nutrient SensingThe role of microalbuminuria and insulin resistance as significant risk factors for white matter lesions in Japanese type 2 diabetic patients.18423105
Microalbuminuria, Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with microalbuminuria and insulin resistance in patients with type 2 diabetic mellitus (DM) not receiving insulin treatment.18423105
MicroalbuminuriaDeregulated Nutrient SensingMultivariate logistic analysis revealed that WML was independently predicted by the microalbuminuria and insulin resistance (p<0.005, p<0.0005, respectively).18423105
MicroalbuminuriaDeregulated Nutrient SensingThe results of this preliminary study indicate that the presence of WML was associated with the microalbuminuria and insulin resistance in these Japanese patients with type 2 DM; larger cohort studies are warranted to confirm these findings.18423105
HyperglycemiaDeregulated Nutrient SensingDespite insulin resistance, however, obese patients did not incur longer periods of hyperglycemia.18426344
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAbout 50% of the patients with diabetes were more often female, with a greater prevalence of hypertension and dyslipidemia.18431886
Familial benign pemphigus, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Obesity, Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingHypertension and hypertensive heart disease (HHD) are inter-related phenotypes frequently observed with other comorbidities such as diabetes, obesity, and dyslipidemia, which probably reflect the complex gene-gene and/or gene-environment interactions resulting in HHD.18435473
Breast CarcinomaDeregulated Nutrient SensingHigh insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome.18437560
Breast CarcinomaDeregulated Nutrient SensingHigh insulin levels in women with locoregional breast cancer reflect the presence of insulin resistance and are associated with other components of the IRS.18437560
Tumor necrosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLeptin and tumor necrosis factor-alpha (TNF-alpha) play important role in homeostasis and insulin resistance in the treatment of Type 2 diabetes (T2DM).18438653
Alzheimers DiseaseDeregulated Nutrient SensingGenetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.18438697
Data types - AddressDeregulated Nutrient SensingWe conclude that there is no real association with SNPs available in the present study between SIRT1, PPARD or PGC-1alpha genes and AD risk in the Finnish population.18438697
Heart Diseases, Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingDiet has been related to several characteristics of metabolic syndrome (MSDR) and insulin resistance, which carry an increased risk for diabetes and heart disease.18442502
Diabetes MellitusDeregulated Nutrient SensingTo examine the cross-sectional association between macronutrient intake, sex, and MSDR and insulin resistance in American Indians without diabetes.18442502
Cerebrovascular Disorders, Dyslipidemias, Cerebrovascular accident, Diabetes MellitusDeregulated Nutrient SensingAlthough they had increased risk factors, including previous stroke (30 of 203 vs 16 of 244, p = 0.004), diabetes (66 of 203 vs 32 of 244, p < 0.0001), cerebrovascular disease (45 of 203 vs 24 of 244, p = 0.003), and dyslipidemia (191 of 203 vs 63 of 244, p < 0.0001), they had better outcomes.18442531
Restenosis, Diabetes MellitusDeregulated Nutrient SensingRobust evidence demonstrates that diabetes mellitus and insulin resistance are among the main risk factors for restenosis in patients requiring percutaneous myocardial revascularization.18442619
Critical IllnessDeregulated Nutrient SensingPrevalence, incidence, and clinical resolution of insulin resistance in critically ill patients: an observational study.18443133
Critical IllnessDeregulated Nutrient SensingThe primary objective of this study was to measure the prevalence, incidence, and resolution of insulin resistance (IR) in critically ill patients.18443133
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingSelective thyromimetics for atherosclerosis and dyslipidaemia: another old target making progress.18447589
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe history of thyromimetics in atherosclerosis and dyslipidaemia is reviewed as the background to the recent publication of the first human data on a new selective thyromimetic, KB-2115 (eprotirome).18447589
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingEffectiveness of a fenofibrate 145-mg nanoparticle tablet formulation compared with the standard 160-mg tablet in patients with coronary heart disease and dyslipidemia.18447655
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingTo compare the effectiveness of a fenofibrate 145-mg nanoparticle tablet formulation with the standard 160-mg tablet in patients with dyslipidemia and coronary heart disease.18447655
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHypertension was reported in 53%, obesity in 27%, dyslipidemia in 26%, and diabetes in 23% of the patients.18448013
Hormone abnormality, Cardiovascular DiseasesDeregulated Nutrient SensingClinical studies suggest that menstrual irregularities are associated with metabolic and hormonal abnormalities, insulin resistance and a hyperestrogenic/hyperandrogenic imbalance, that may influence the risk of cardiovascular disease.18450435
Inflammation, Albuminuria, Obesity, Congestive heart failureDeregulated Nutrient SensingRecently, increasing interest has emerged on the potential role of novel risk factors such as systemic inflammation, insulin resistance, and albuminuria in the pathophysiology of CHF and their relationship with obesity.18452784
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingMost patients exhibited cardiovascular risk factors other than dyslipidemia: hypertension in 34%, diabetes in 11%, and smoking in 18%.18456039
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance is a risk factor for NASH and GD.18459024
Gall Bladder Diseases, Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance was more common in concurrent NASH and gallbladder disease.18459024
Fibrosis Assessment, Gall Bladder Diseases, Fatty Liver DiseaseDeregulated Nutrient SensingThe mechanism between insulin resistance, fibrosis stage, NASH, and gallbladder disease is unknown.18459024
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn persons with impaired glucose tolerance (IGT), both impaired insulin secretion and insulin resistance contribute to the conversion to type 2 diabetes mellitus (T2DM).18460558
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe investigated the association of -1131T>C and S19W polymorphisms with diabetic dyslipidemia in 400 Caucasian T2D patients divided in 2 groups: group N with 130 normotriglyceridemics (TG<90th percentile) and group M with 270 moderately hypertriglyceridemics.18468520
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results suggest that in T2D APOA5 polymorphisms contribute to modulate dyslipidemia.18468520
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and type 2 diabetes are associated with an atherogenic lipoprotein profile.18469202
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined the role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated with type 2 diabetes.18469202
DyslipidemiasDeregulated Nutrient SensingImpact of dyslipidaemia on arterial structure and function in urban indigenous Australians.18471818
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia (low HDL-cholesterol or elevated triglycerides) is independently associated with non-invasive measures of cardiovascular disease in a relatively healthy and young subgroup of this high-risk population.18471818
Cerebrovascular DisordersDeregulated Nutrient SensingOn the other hand, insulin resistance represents an independent factor in the etiology of age-associated coronary and cerebrovascular disease.18473910
Federated States of MicronesiaDeregulated Nutrient SensingThe present study may suggest possible involvement of adiponectin in bone metabolism, independently of FM and insulin resistance even in elderly post-menopausal women.18475046
Weight decreasedDeregulated Nutrient SensingShort-term dietary weight loss can improve insulin resistance but long-term studies are lacking.18476986
diabeticDeregulated Nutrient SensingThiazolidine derivatives increase circulating adiponectin, particularly the high molecular weight isoform, which has been shown to well correlate with amelioration of insulin resistance by thiazolidines in diabetic patients.18480556
Diabetes Mellitus, Non-Insulin-Dependent, square decimeter, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD).18482457
Coronary StenosisDeregulated Nutrient SensingAssociation of insulin resistance with de novo coronary stenosis after percutaneous coronary artery intervention in hemodialysis patients.18483462
AtherosclerosisDeregulated Nutrient SensingInsulin resistance may be involved in the progression of nonculprit coronary atherosclerosis after PCI in hemodialysis patients.18483462
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe gender, age, incidence of hypertension, diabetics, smoking, and dyslipidemia were similar among the three groups.18484157
Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo reveal the exact link between adipose tissue, inflammation, and cardiovascular disease (CVD), we studied the association of C-reactive protein (CRP) with insulin resistance and adipocytokines in Asian Indian subjects.18484906
Inflammation, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingThe association of CRP with insulin resistance, adipocytokines, and resistin reveals close links between inflammation, CVD, and adipose tissue.18484906
Communicable Diseases, Steatohepatitis, Hepatitis C, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVirus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. Hepatitis C virus (HCV) infection disturbs glucose and lipid metabolism contributing to the development of liver steatosis, insulin resistance and type 2 diabetes mellitus.18486982
Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingOn the other hand, insulin resistance and steatosis have been found to be associated with increased rates of fibrosis progression and lower rates of response to interferon therapy in chronic hepatitis C (CHC).18486982
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingThe molecular mechanisms contributing to insulin resistance in CHC are not well understood.18486982
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingHCV-induced over-expression of PP2A in the liver contributes to the pathogenesis of insulin resistance in patients with CHC.18486982
Diabetes MellitusDeregulated Nutrient SensingReduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes.18488190
Diabetes MellitusDeregulated Nutrient SensingAdverse levels of adipokines are associated with insulin resistance in individuals at low or high diabetes risk.18492747
Diabetes Mellitus, Non-Insulin-Dependent, square decimeter, ObesityDeregulated Nutrient SensingAdaptation to states of enhanced metabolic demand is associated with increased glucose metabolism and GLUT4 gene expression, whereas states of insulin resistance such as type 2 diabetes mellitus (DM2), obesity, and aging are associated with impaired regulation of GLUT4 gene expression and function.18492767
CaviaDeregulated Nutrient SensingThe HMW-to-total ADPN ratio, a better predictor for insulin resistance, was significantly and positively correlated with PWV (r = 0.34, p < 0.01) and CAVI (r = 0.24, p = 0.05).18493156
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion, peripheral insulin resistance, and increased hepatic glucose production.18496642
Diabetes MellitusDeregulated Nutrient SensingIGFBP-1 increased 32% (95% CI 17-49%) during the 10 years in those developing diabetes and was increased in relation to insulin levels, suggesting the emergence of hepatic insulin resistance.18496669
Dyslipidemias, Spinal FracturesDeregulated Nutrient SensingBy logistic regression analysis with multivariate adjustment, age (P < 0.01), dyslipidemia (P < 0.05), and the presence of vertebral fracture (P < 0.05) were independent risk factors for echogenic carotid plaques.18496724
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelation among left ventricular mass, insulin resistance, and hemodynamic parameters in type 2 diabetes.18497461
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAge-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions.18501007
Polycystic Ovary SyndromeDeregulated Nutrient SensingThe evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function.18501898
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThere was a significant insulin resistance in PCOS patients.18501898
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingExistence of insulin resistance alone may not be an adequate factor for deterioration of endothelial function and carotid IMT in young, nonobese patients with PCOS.18501898
ObesityDeregulated Nutrient SensingOther factors such as duration of insulin resistance, older age, presence of obesity, and inflammatory markers may play an important role in this process.18501898
DyslipidemiasDeregulated Nutrient SensingUraemic dyslipidaemia, which is characterized by low HDL-cholesterol (HDL-C) and elevated triglycerides' levels, may contribute to this elevated cardiovascular risk.18503096
Dyslipidemias, Chronic rejection of renal transplantDeregulated Nutrient SensingClinical correlation between dyslipidemia and pediatric chronic allograft nephropathy.18503482
Dyslipidemias, HaitiDeregulated Nutrient SensingThis study provides suggestive evidence that treatment with ezetimibe plus low-dose simvastatin is well tolerated by HT recipients and may be effective for treatment of dyslipidemia in HT recipients with statins intolerance or resistance.18503971
ObesityDeregulated Nutrient SensingImpaired endothelial function in obesity may reduce blood flow to sites of metabolism, contributing to impaired fat oxidation and insulin resistance.18504447
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingThe prevalence of hypertension, impaired glucose metabolism, dyslipidemia, and obesity was 45%, 65%, 65%, and 25%, respectively.18506093
Dyslipidemias, Overweight, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHigh prevalence factors for cardiovascular risk were observed, such as: overweight and obesity, hypertension, dyslipidemia, sedentariness and inadequate diet.18506342
Dyslipidemias, Alagille SyndromeDeregulated Nutrient SensingDyslipidemia does not seem to be a phenotypic expression in first degree relatives of children with Alagille syndrome.18507066
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose.18509807
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpaired acute insulin response (AIR) and insulin resistance (IR) are characteristics of Type 2 diabetes (T2DM).18509807
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4) has been found to induce insulin resistance and to be increased in type 2 diabetes.18514142
Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, Insulin resistance syndromeDeregulated Nutrient SensingThe reduction of muscle mass may be responsible for reduced insulin sensitivity and decreased glucose uptake, thus increasing the risk for hyperglycemia and insulin-resistance syndrome in elderly subjects with type 2 diabetes mellitus.18514633
Hypertension, CTCAEDeregulated Nutrient SensingTo identify important factors that may contribute to abnormal glucose tolerance in elderly patients with treated hypertension with primary reference to changes in the following parameters: calculated insulin resistance, endogenous insulin processing and secretion; platelet cation concentration and membrane ATPase activity.18516349
Hypertensive (finding)Deregulated Nutrient SensingThe derived measure of insulin resistance in the hypertensive patients showed a significant increase in the progression from NG to IGT and DM.18516349
Hypertension, CTCAEDeregulated Nutrient SensingOur findings support the strong link between essential hypertension, insulin resistance/hyperinsulinaemia and regional adiposity.18516349
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is considered one of the main risk factors for cardiovascular disease (CVD), which is more frequent in older individuals.18516398
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAt 6-month follow-up, the patient continued to have elevated glycosylated hemoglobin, hypertension, dyslipidemia, and excess weight.18519838
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of leptin with insulin resistance, body composition, and lipid parameters in postmenopausal women and men in type 2 diabetes mellitus.18521457
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine the association of leptin with insulin resistance, body composition, and lipid parameters in postmenopausal women and men with type 2 diabetes mellitus (T2DM).18521457
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingType 2 diabetes mellitus seemed more effective on insulin resistance than obesity.18521457
Proteinuria, Albuminuria, diabeticDeregulated Nutrient SensingDiabetic patients with MVC and mvc had higher insulin resistance, higher plasmatic levels of total homocysteine and a higher incidence ofalbuminuria or proteinuria.18522290
Glucose Intolerance (disease), Diabetes Mellitus, Blood GlucoseDeregulated Nutrient SensingThere is a moderate prevalence of diabetes and a high prevalence of total disorders of glycemia, which suggests that this community, unlike other rural communities in Africa, is well into an epidemic of glucose intolerance.18523142
Data types - AddressDeregulated Nutrient SensingWe used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity.18525125
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe purpose of this study is to explore the attitudes that contribute to psychological insulin resistance (PIR) in insulin-naive patients with type 2 diabetes and to identify predictors of PIR.18535324
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThis process is dampened in patients with diabetes mellitus and dyslipidemia.18535371
PathologyDeregulated Nutrient SensingModulation of SIRT1 expression in different neurodegenerative models and human pathologies.18538940
PathologyDeregulated Nutrient SensingWe examined the expression of SIRT1 in several experimental paradigms of human pathologies.18538940
Neurotoxicity SyndromesDeregulated Nutrient SensingSubsequently, SIRT1 expression was compared in these different paradigms of neurotoxicity.18538940
HD Term TypeDeregulated Nutrient SensingSIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses.18538940
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe emergence of type 2 diabetes in young populations has mirrored a rising prevalence of obesity and insulin resistance during childhood and adolescence.18539644
ObesityDeregulated Nutrient SensingAt the same time, the role of adipokines as links between obesity and insulin resistance is becoming more appreciated.18539644
metabolic disturbanceDeregulated Nutrient SensingThe metabolic disturbances associated with insulin resistance appear to be more advanced in girls.18539644
Inflammation, Congenital neurologic anomalies, Dyslipidemias, Coronary Arteriosclerosis, Renal Insufficiency, Hypertension, CTCAEDeregulated Nutrient SensingIn the general population, RVO is associated with hypertension, dyslipidemia, and renal dysfunction, but not with atherosclerotic disease, systemic inflammation, and hematologic abnormalities.18539932
Weight Gain, Diabetes Mellitus, Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe accelerator/beta-cell stress hypothesis regards insulin resistance as one common basis for type 1 and type 2 diabetes and weight increase as an important trigger of type 1 diabetes.18540867
Hypertension, CTCAEDeregulated Nutrient SensingObesity-related cardiometabolic risk factors contribute to interindividual variation in REE, with hypertension and insulin resistance being associated with a higher REE.18541558
Dyslipidemias, Aortic valve disorderDeregulated Nutrient SensingThese findings may have important implications for the efficacy of and targets for dyslipidemia therapies in calcific aortic valve disease.18541828
Dyslipidemias, Hypertension, CTCAE, Alcoholic Intoxication, Chronic, Diabetes MellitusDeregulated Nutrient SensingThe risk factors were: arterial hypertension, 40.3%; smoking, 32.7%; dyslipidemia, 16.0%; diabetes mellitus, 10.6%; alcoholism, 6.7%.18543194
DyslipidemiasDeregulated Nutrient SensingAlthough visceral adipose tissue (VAT) has been strongly linked with dyslipidemia, the importance of intermuscular adipose tissue (IMAT) to dyslipidemia and exercise responses is less well understood.18544640
DyslipidemiasDeregulated Nutrient SensingReducing IMAT through aerobic exercise may be functionally related to some improvements in atherogenic dyslipidemia in men.18544640
Adrenal Gland HyperfunctionDeregulated Nutrient SensingGrowth hormone (GH) deficiency and hypercortisolemia predispose to abdominal adiposity and insulin resistance, and GH secretion is decreased in obese adults.18544645
OverweightDeregulated Nutrient SensingWe hypothesized that low-peak GH on the GH-releasing hormone (GHRH)-arginine stimulation test and high cortisol in overweight adolescents would be associated with higher regional fat, insulin resistance, and lipids.18544645
DyslipidemiasDeregulated Nutrient SensingThis increased prevalence was due to dyslipidemias rather than higher blood pressure, glucose, or waist circumference.18545157
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingWe have evaluated the use of the immunosuppressant mycophenolate mofetil (MMF) in the treatment of severe insulin resistance caused by neutralising anti-insulin antibodies in type 1 diabetes mellitus (T1DM).18547238
SchizophreniaDeregulated Nutrient SensingPrevalence of insulin resistance in schizophrenia in HUKM.18551931
Microalbuminuria, HypertriglyceridemiaDeregulated Nutrient SensingInsulin resistance is the major determinant for microalbuminuria in severe hypertriglyceridemia: implication for high-risk stratification.18552465
Diabetes Mellitus, Non-Insulin-Dependent, Polycystic Ovary SyndromeDeregulated Nutrient SensingAn observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet.18555837
Polycystic Ovary SyndromeDeregulated Nutrient SensingLow birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome.18555843
Peripheral Vascular Diseases, InflammationDeregulated Nutrient SensingAssociation of insulin resistance and inflammation with peripheral arterial disease: the National Health and Nutrition Examination Survey, 1999 to 2004.18559705
Peripheral Vascular Diseases, InflammationDeregulated Nutrient SensingAlthough the role of inflammation in the pathophysiology of peripheral arterial disease (PAD) is well established, the contribution of insulin resistance (IR) to PAD is less clear.18559705
Prostate Cancer Outcomes Study, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPCOS cases exhibit an adverse coronary heart disease (CHD) profile at an early age, including insulin resistance, dyslipidemia and increased central adiposity.18561521
Calcification of coronary artery, Chronic Kidney DiseasesDeregulated Nutrient SensingCoronary artery calcification, ADMA, and insulin resistance in CKD patients.18562597
SLC25A20 geneDeregulated Nutrient SensingHowever, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC.18562597
Chronic kidney disease mineral and bone disorder, SLC25A20 geneDeregulated Nutrient SensingCAC becomes more prevalent and severe with a decline in GFR, and plasma ADMA levels and insulin resistance, independent of factors associated with CKD-MBD, are correlated with CAC.18562597
Hyperglycemia, Metabolic Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by insulin resistance and hyperglycemia.18564365
Malignant tumor of colon, HypertriglyceridemiaDeregulated Nutrient SensingEpidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer.18565233
Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Anemia, Obesity, Kidney FailureDeregulated Nutrient SensingThe prevalence of comorbidities was high: atrial fibrillation, 46%; diabetes, 38%; obesity, 64%; dyslipidemia, 60%; anemia, 27%; and renal failure, 7%.18570782
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingRelationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children.18571268
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIt has been known that nonalcoholic fatty liver disease (NAFLD) as one of obesity-related comorbidities is related with insulin resistance.18571268
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingSo, we investigated the relation between insulin resistance and NAFLD, using serum alanine aminotransferase (ALT) as a surrogate of NAFLD among obese children in Korea.18571268
Weight decreased, DyslipidemiasDeregulated Nutrient SensingWeight loss in the CRD group led to improvements in both insulin sensitivity and dyslipidemia, but the change in the former was less than in RSG-treated patients, and improvement in lipid metabolism not as great as with FEN.18572037
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingSafety and efficacy of simvastatin for the treatment of dyslipidemia in human immunodeficiency virus-infected patients receiving efavirenz-based highly active antiretroviral therapy.18576906
DyslipidemiasDeregulated Nutrient SensingThese preliminary comparative data suggest that simvastatin can be safely and effectively used to treat dyslipidemia in HIV-infected patients receiving efavirenz-based HAART without compromising viral or immunologic control.18576906
leukemia, DiseaseDeregulated Nutrient SensingA similar prevalence has also been reported in older children evaluated echocardiographically for other diseases such as insulin-resistance and leukemia.18577303
Diabetes MellitusDeregulated Nutrient SensingTreatment with pioglitazone increased plasma adiponectin levels and improved ED-FMD in patients with stable CAD and no evidence of diabetes or insulin resistance.18580598
HypercholesterolemiaDeregulated Nutrient SensingSignificant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance.18581044
Hypercholesterolemia, Cardiovascular DiseasesDeregulated Nutrient SensingIt is supposed that the coexistence of higher insulin resistance and hypercholesterolemia for carriers of the D19H polymorphism may result in a greater risk of cardiovascular disease.18581044
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingClinical variables increasing the likelihood of full screening were clozapine treatment and a known diagnosis of diabetes or dyslipidaemia.18582345
Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingPrevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004.18585505
DyslipidemiasDeregulated Nutrient SensingImproved treatment efforts to target the spectrum of dyslipidemia are needed.18585505
Dyslipidemias, Depression, CTCAE, ObesityDeregulated Nutrient SensingThose in the weight-loss group were less likely to be in a race group at higher risk for obesity, have depression or dyslipidemia, or have taken >30 days of a sulfonylurea alone or with metformin.18587618
DyslipidemiasDeregulated Nutrient SensingHighly active antiviral therapy (HAART) results in a sharp decrease in HIV-related morbidity and mortality, but also induces adverse effects such as dyslipidemia, which is difficult treat because of drug interactions.18588813
DyslipidemiasDeregulated Nutrient SensingRosuvastatin was safe and effective for treating dyslipidemia in HAART-treated HIV-infected patients.18588813
Obesity, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines.18589336
Hyperglycemia, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingInsulin resistance is associated with hyperglycemia and dyslipidemia and promotes atherosclerosis.18589336
Cerebrovascular accident, Diabetes MellitusDeregulated Nutrient SensingAlthough insulin resistance is associated with adipocytokines, little is known about the association in patients with stroke without diabetes mellitus.18589336
Tumor necrosisDeregulated Nutrient SensingWe measured insulin resistance, the plasma level of tumor necrosis factor (TNF)-alpha, adiponectin, and the visceral fat area.18589336
Increased insulin levelDeregulated Nutrient SensingIn all, 21 of 60 patients (35.0%) had insulin resistance and 35 (58.3%) had hyperinsulinemia.18589336
Cerebrovascular accident, AtherosclerosisDeregulated Nutrient SensingWe recommend that obese patients with stroke should be examined for insulin resistance to reduce the risk of the development of atherosclerosis.18589336
Blood GlucoseDeregulated Nutrient SensingThis prospective study reports inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance.18591391
LipodystrophyDeregulated Nutrient SensingLoss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld mouse, and LPIN1 expression and common genetic variation were recently suggested to influence adiposity and insulin sensitivity in humans.18591397
Lipodystrophy, Unknown (origin) (qualifier value)Deregulated Nutrient SensingLPIN1 exons, exon/intron boundaries, and 3' untranslated region were sequenced in 158 patients with idiopathic severe insulin resistance (including 23 lipodystrophic patients) and 48 control subjects.18591397
HIV InfectionsDeregulated Nutrient SensingInsulin resistance in HIV infection: drugs, host responses, or restoration to health?18591716
HyperlipidemiaDeregulated Nutrient SensingProtease inhibitors (PIs) are widely assumed to be associated with a syndrome of insulin resistance accompanied by hyperlipidemia and fat redistribution.18591716
HIV InfectionsDeregulated Nutrient SensingThis article summarizes a presentation on insulin resistance in HIV infection made by Carl Grunfeld, MD, PhD, at the 10th Annual Ryan White HIV/AIDS Program Clinical Update in Phoenix in June 2007.18591716
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingThe findings provide important evidence concerning the hypertension as a public health problem and its association with dyslipidemia and abdominal obesity in the rural area of Minas Gerais.18592091
Critical IllnessDeregulated Nutrient SensingInsulin resistance is common and often multifactorial in acutely critically ill patients.18595867
Aortic Aneurysm, ThoracicDeregulated Nutrient SensingThe authors present a case in which a patient developed severe insulin resistance following surgical repair of a thoracic aorta aneurysm.18595867
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension was present in 1524 (78.1%) and dyslipidemia in 764 (39.1%).18596402
DyslipidemiasDeregulated Nutrient SensingThe dyslipidaemia was equally severe in both genders.18599067
Dyslipidemias, MS geneDeregulated Nutrient SensingExcess risk for low HDL-C, dyslipidemia and MS is associated with the rare alleles of the APOA5 SNPs and non-carriers of common haplotype in women.18601598
AtherosclerosisDeregulated Nutrient SensingBefore telmisartan therapy, low preheparin LpL mass concentration was closely associated with the pathogenesis of insulin resistance and the presence of coronary atherosclerosis.18603820
Coronary heart diseaseDeregulated Nutrient SensingQuality of life and insulin resistance in patients with coronary heart disease.18607164
Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingIn patients with coronary heart disease and without known diabetes mellitus an estimated measure of quality of life was significantly and independently associated with poor insulin resistance.18607164
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingUsing coding data from an electronic medical record to identify all adults with an underlying diagnosis of hyperlipidemia enrolled to this PBRN, children at risk for dyslipidemia were identified.18612063
Diabetes MellitusDeregulated Nutrient SensingAmong well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance.18612115
ACACA wt AlleleDeregulated Nutrient SensingAs rates of fatty acid oxidation can influence the ability of the heart to withstand an ischemic insult, we examined the expression of MCD, ACC, and AMPK in the newborn human heart.18614968
ACACA wt AlleleDeregulated Nutrient SensingIn contrast, a negative correlation in both ACC and AMPK expression and age was observed.18614968
ACACA wt AlleleDeregulated Nutrient SensingThis indicates that increased expression of MCD, and the decreased expression of ACC and AMPK are important regulators of the maturation of fatty acid oxidation in the newborn human heart.18614968
Thrombosis, Hypertension, CTCAE, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingStroke patients in particular can benefit from pharmacotherapy for thrombosis, hypertension, and dyslipidemia but are at high risk for medication nonpersistence.18616796
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingEligible adults were aged > or =25, overweight or obese (BMI=25-45 kg/m2), and on medications for hypertension and/or dyslipidemia.18617080
Increased insulin level, Colorectal CarcinomaDeregulated Nutrient SensingEvidence implicating hyperinsulinemia and insulin resistance in the etiology of colorectal cancer suggests that a diet characterized by a high glycemic index and load may increase the risk of this disease, but previous studies have yielded inconsistent results.18618276
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe HIV patients had a greater prevalence of dyslipidemia, diabetes, and PAD, which was symptomatic in five of them and in one subject from the general population.18620492
No metabolic abnormalitiesDeregulated Nutrient SensingImpaired restrictive pulmonary function has been reported to be associated with insulin resistance and metabolic abnormalities.18625672
Abnormality of mitochondrial metabolismDeregulated Nutrient SensingRecent studies suggest that mitochondrial dysfunction and impaired expression of genes involved in oxidative phosphorylation (OXPHOS) may play a key role in the pathogenesis of insulin resistance in aging and type 2 diabetes.18628517
Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingHowever, the study does not support the hypothesis that muscle mitochondrial dysfunction per se is the underlying key metabolic defect that explains or precedes whole body insulin resistance in LBW subjects at risk for developing type 2 diabetes.18628517
Dyslipidemias, Hypertension, CTCAE, NeuropathyDeregulated Nutrient SensingHypertension (73.1%), dyslipidemia (63.2%), and neuropathy (52.1%) were the most common co-morbidities.18632023
Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingTelmisartan, an angiotensin II type 1 receptor blocker, improves coronary microcirculation and insulin resistance among essential hypertensive patients without left ventricular hypertrophy.18633172
Hypertension, CTCAEDeregulated Nutrient SensingHypertension and insulin resistance are associated with reduced coronary vasodilatory capacity, possibly caused by structural changes in the coronary resistance vessels.18633172
Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingThe goal of this study was to compare the effect of an angiotensin receptor blocker (ARB) with that of a calcium channel blocker (CCB) on coronary flow reserve and insulin resistance among essential hypertensive patients without left ventricular hypertrophy.18633172
Hypertensive (finding)Deregulated Nutrient SensingIn conclusion, this study demonstrates that antihypertensive therapy with telmisartan, but not nifedipine, has a beneficial effect on coronary microcirculation and insulin resistance among essential hypertensive patients.18633172
Hypertension, CTCAEDeregulated Nutrient SensingHOMA-estimated insulin resistance is associated with hypertension in Iranian diabetic and non-diabetic subjects.18633753
Hyperglycemia, Critical IllnessDeregulated Nutrient SensingThe cornerstone of hyperglycaemia in critically ill patients is insulin resistance and it remains refractory to intensive insulin protocols.18636232
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingWe found several synergistic effects between the studied polymorphisms and classical risk factors such as hypertension, obesity, diabetes and dyslipidaemia: the presence of the DD genotype of ACE I/D (and also ACE11860 GG) increases the odds of developing CAD when associated to each one of these classical risk factors, particularly when considering the male and early onset CAD subgroup analysis; AGT235 TT also increases the CAD risk in the presence of hypertension and dyslipidaemia, and AT1R1166 interacts positively with hypertension, smoking and obesity.18637188
Prostate carcinomaDeregulated Nutrient SensingExpression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.18637271
Prostate carcinomaDeregulated Nutrient SensingEZH2 expression increases during prostate cancer progression, whereas BMI-1 and SIRT1 are not well investigated.18637271
Malignant neoplasm of prostateDeregulated Nutrient SensingExpression of EZH2, BMI-1, SIRT1, and the DNA methyltransferases DNMT1 and DNMT3B measured by qRT-PCR in 47 primary prostate cancers was compared to APC, ASC, GSTP1, RARB2, and RASSF1A hypermethylation and LINE-1 hypomethylation.18637271
Malignant neoplasm of prostateDeregulated Nutrient SensingSIRT1 appears to be generally increased in prostate cancers.18637271
Dyslipidemias, Angina Pectoris, Congestive heart failureDeregulated Nutrient SensingPatients in the SES group had more dyslipidemia, history of congestive heart failure, and ostial lesions; patients treated with PES had more previous coronary artery bypass surgery, unstable angina, and type C lesions.18638589
ObesityDeregulated Nutrient SensingElevated serum retinol-binding protein (RBP) concentration has been associated with obesity and insulin resistance, but accompanying retinol values have not been reported.18641048
ObesityDeregulated Nutrient SensingInvestigations into the role of RBP in obesity and insulin resistance should include retinol to facilitate the measurement of apo-RBP and retinol:RBP.18641048
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDiabetes was defined as FPG > or = 6.93 mmol/L; dyslipidemia was based on Adult Treatment Panel III and hypertension on Joint National Committee VI recommendations.18641193
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of at least 1 risk factor and at least 2 risk factors of the 3 major risk factors for cardiovascular disease (hypertension, dyslipidemia, and diabetes) was also evaluated.18641193
Primary malignant neoplasm, DyslipidemiasDeregulated Nutrient SensingMonitoring of the lipid profile should be considered in cancer patients receiving capecitabine, particularly those with a known diagnosis of dyslipidemia.18641989
Dyslipidemias, Blood Coagulation Disorders, Inherited, Fatty Liver DiseaseDeregulated Nutrient SensingFatty liver disease is mainly caused by alcohol consumption, excessive body weight, dyslipidemia and impaired glucose tolerance, but inherited disorders can sometimes be involved.18644654
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSince the mortality rate due to cardiovascular disease continues to increase, research into dyslipidemia has been emphasized in not only adults but also paediatric populations.18647280
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFor each child, data were collected on body height (cm), body weight (kg), sitting height (cm), waist circumference, upper arm circumference, serum lipid levels, as well as familial history of dyslipidemia and early onset cardiovascular disease.18647280
DyslipidemiasDeregulated Nutrient SensingLogistic regression analysis suggested that WHR, diastolic blood pressure and positive familial history were risk factors for dyslipidemia in children.18647280
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingBMI, WHR, diastolic pressure and familial history of dyslipidemia and early-onset cardiovascular disease were risk factors for dyslipidemia in Chinese children.18647280
Dyslipidemias, Fatty degeneration, Diabetes Mellitus, Obesity, Hyperuricemia, OverweightDeregulated Nutrient SensingThe prevalence of overweight, obesity, diabetes, dyslipidemia and hyperuricemia were also significantly higher in patients with steatosis than those without it (chi2 values 17.00, 169.45, 6.12, 116.67 and 76.34, all P less than 0.05).18647531
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.18647954
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular systemDeregulated Nutrient SensingAll women at high risk for cardiovascular death have accelerated telomere erosion, not caused by type 2 diabetes per se but likely linked to other risk factors, including dyslipidemia.18650367
Hypertension, CTCAEDeregulated Nutrient SensingThere were significant interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension, corresponding relative excess risk due to interactions were 0.799 and 0.651, respectively.18654021
Hypertension, CTCAEDeregulated Nutrient SensingIncreased CRP was associated with hypertension, there were interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension in Mongolian people.18654021
Dyslipidemias, ObesityDeregulated Nutrient SensingThe objective of the study was to identify the prevalence of obesity and dyslipidaemia in primary care physicians.18664023
Dyslipidemias, ObesityDeregulated Nutrient SensingIn Mexico the prevalence of obesity and dyslipidaemia in primary care physicians was higher than expected.18664023
Structure of posterior cerebral arteryDeregulated Nutrient SensingWhile in BPH serum resistin levels correlated with insulin resistance, inflammatory status and cortisol, in PCa positive correlation with F/T PSA ratio and cortisol was observed.18665756
HD Term Type, Dyslipidemias, Vascular DiseasesDeregulated Nutrient SensingPlasma adiponectin and leptin are expected as contributors related to dyslipidemia, suggesting these may be targets of prevention of vascular diseases in maintenance HD patients.18670142
Endothelial dysfunction, Postprandial hyperlactemiaDeregulated Nutrient SensingInsulin resistance is associated with postprandial hyperlipidemia and endothelial dysfunction.18670365
Metabolic Syndrome XDeregulated Nutrient SensingPatients with metabolic syndrome, characterized by insulin resistance, are at increased cardiovascular risk.18670365
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe main associated diseases were hypertension, dyslipidemia, and diabetes.18672602
Renal Insufficiency, DyslipidemiasDeregulated Nutrient SensingPopulation pharmacokinetics of rosuvastatin: implications of renal impairment, race, and dyslipidaemia.18674408
Dyslipidemias, Kidney FailureDeregulated Nutrient SensingA population pharmacokinetic analysis of rosuvastatin in healthy volunteers, subjects with dyslipidaemia, and renal failure patients was performed using non-linear mixed-effects modelling and a two-compartment pharmacokinetic model with simultaneous first- and zero-order absorption.18674408
DyslipidemiasDeregulated Nutrient SensingRosuvastatin CL/F was reduced in subjects with dyslipidaemia, but it is important to realise that the safety/efficacy profile of rosuvastatin has been well established in this population.18674408
CD55 gene, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThis analysis explores what proportion of the UK population with cardiovascular disease (CVD) and TC levels at or below target may still be at risk because of residual dyslipidaemia.18674409
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients with diabetes were more likely than non-diabetics to have abnormalities of both HDL-C (28.9 vs. 16.4%; p<0.0001) and triglyceride (44.9 vs. 29.5%; p<0.0001) despite normal TC and LDL-C. Around 60% of high-risk patients have residual dyslipidaemias despite achieving the Quality and Outcomes Framework (QOF) TC target.18674409
Neurologic Deficits, Stanford Cancer Institute, Diabetes MellitusDeregulated Nutrient SensingNeurologic deficit combined with increased insulin resistance has a greater macrovascular impact on SCI veterans than on those who do not have diabetes.18674979
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is common in patients with chronic kidney disease.18676075
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingIn hypertensive patients with moderate dyslipidemia and decreased eGFR, pravastatin was not superior to usual care in preventing clinical renal outcomes.18676075
Hyperlipidemia, metabolic disturbanceDeregulated Nutrient SensingBoth conditions can be very disturbing to patients and have been associated with metabolic disturbances such as insulin resistance and hyperlipidemias.18677013
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEfficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitus.18678301
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis randomized, multicenter, double-blinded, placebo-controlled study evaluated the efficacy and safety of CP-778,875 in subjects with mixed dyslipidemia and type 2 diabetes.18678301
Amyotrophic Lateral Sclerosis, DyslipidemiasDeregulated Nutrient SensingOur findings indicate that statins treatment for dyslipidemia in patients with ALS does not carry any survival risks.18678378
OverweightDeregulated Nutrient SensingEstimating insulin resistance may inform dietary recommendations for overweight children.18678809
HPT geneDeregulated Nutrient SensingIn this sample of originally normotensive men, circulating LPT level was a significant predictor of the risk to develop HPT over 8 yr, independently of BMI and insulin resistance.18682500
Polycystic Ovary Syndrome, Ventricular Dysfunction, LeftDeregulated Nutrient SensingSubclinical impairment of left ventricular function in young obese women: contributions of polycystic ovary disease and insulin resistance.18682502
ObesityDeregulated Nutrient SensingObesity and insulin resistance (IR) may produce disturbances of left ventricular (LV) function.18682502
Apolipoproteins B, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingApolipoprotein B and insulin resistance are good markers of carotid atherosclerosis in patients with type 2 diabetes mellitus.18684539
Carotid Atherosclerosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this study, we investigated that Apo B concentrations and insulin resistance (HOMA-R) can be good markers of carotid atherosclerosis in patients with type 2 diabetes.18684539
Cessation of life, DyslipidemiasDeregulated Nutrient SensingThe 2006 Canadian dyslipidemia guidelines will prevent more deaths while treating fewer people--but should they be further modified?18685741
Cessation of life, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingTo compare the effectiveness and efficiency of the 2003 and 2006 Canadian dyslipidemia guidelines for statin treatment in reducing deaths from coronary artery disease (CAD) in the Canadian population.18685741
Cessation of life, DyslipidemiasDeregulated Nutrient SensingFrom a population perspective, the 2006 Canadian dyslipidemia recommendations are an improvement of earlier versions, preventing more CAD events and deaths with fewer statin prescriptions.18685741
Critical IllnessDeregulated Nutrient SensingTo observe the changes in blood glucose, serum insulin level and insulin resistance of critically ill patients during the acute stage and explore the relationship between the changes and their prognosis.18687177
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPattern of dyslipidaemia among Nigerians with type 2 diabetes mellitus.18689135
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia is common among patients with type 2 diabetes mellitus in Nigeria with majority of the patients having a combined dyslipidaemia.18689135
Increased insulin level, Pancreatic carcinoma, HyperglycemiaDeregulated Nutrient SensingAlthough it has been hypothesized that hyperglycemia, hyperinsulinemia, and insulin resistance are involved in the development of pancreatic cancer, results from epidemiologic studies of added sugar intake are inconclusive.18689380
Dyslipidemias, ThrombocytopeniaDeregulated Nutrient SensingDanazol was resumed to treat persistent thrombocytopenia, while lovastatin was replaced with ezetimibe 10 mg QD to treat high cholesterol (dyslipidemia).18691993
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population.18692268
Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe sterol regulatory element-binding protein (SREBP)-1c gene has been identified as a susceptibility gene in metabolic diseases such as type 2 diabetes mellitus (T2DM), obesity, dyslipidemia and insulin resistance.18692268
diabeticDeregulated Nutrient SensingMoreover, the SNP (rs11868035) is closely related to insulin resistance (IR) in diabetic patients.18692268
DyslipidemiasDeregulated Nutrient SensingThese findings indicate that the SREBP-1c SNPs rs2297508 and rs11868035 are associated with a significantly increased risk of T2DM and dyslipidemia in the Chinese population.18692268
Hypertensive (finding), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe angiotensin II receptor blocker telmisartan improves insulin resistance and has beneficial effects in hypertensive patients with type 2 diabetes and poor glycemic control.18692932
Hypertensive (finding), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results indicate that telmisartan improves insulin resistance and gives beneficial effects in hypertensive patients with type 2 diabetes and a poor glycemic control.18692932
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingWe collected data on smoking, diabetes, hypertension, dyslipidemia, and cardiovascular disease history.18692981
OverweightDeregulated Nutrient SensingInsulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren.18693476
Diabetes MellitusDeregulated Nutrient SensingIn addition, a notable increase in the risk of insulin resistance and type 2 diabetes mellitus has emerged.18693476
OverweightDeregulated Nutrient SensingTo determine the prevalence of insulin resistance and impaired glucose tolerance in overweight and obese schoolchildren.18693476
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of impaired glucose tolerance and insulin resistance in obese children indicates a worrisome trend in the incidence of type 2 diabetes in Costa Rica.18693476
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is a major risk factor of cardiovascular disease in patients on maintenance haemodialysis.18693593
Obesity, AtherosclerosisDeregulated Nutrient SensingObesity represents a risk factor for insulin resistance, type 2 diabetes mellitus, and atherosclerosis.18695074
Obesity, AtherosclerosisDeregulated Nutrient SensingA metabolically benign obesity that is not accompanied by insulin resistance and early atherosclerosis exists in humans.18695074
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe coronary artery disease (CAD) risk factors were smoking (66%), hypertension (41%), diabetes mellitus (44%), and dyslipidemia (46%).18697380
Hypertension, CTCAE, Blood GlucoseDeregulated Nutrient SensingA prospective study of glycemia, body size, insulin resistance and the risk of hypertension in Mauritius.18698207
Haplotypes, Diabetes MellitusDeregulated Nutrient SensingIn addition, the 1221/1121 haplogenotype is under-represented in individuals that fulfil the International Diabetes Federation (IDF) diagnostic criteria for MS. Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population.18698425
Acanthosis NigricansDeregulated Nutrient SensingThe second objective was determining the relation of acanthosis nigricans and insulin-resistance.18700035
Acanthosis NigricansDeregulated Nutrient SensingNo statistical significance was found between the presence of acanthosis nigricans and insulin resistance.18700035
ObesityDeregulated Nutrient SensingInsulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence.18700035
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia is one of the major risk factors of coronary artery disease.18700621
Inflammation, Diabetes MellitusDeregulated Nutrient SensingInflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.18700811
Blood Glucose, Diabetes MellitusDeregulated Nutrient SensingObserved associations between serum CRP and insulin resistance, glycemia, and diabetes are likely to be noncausal.18700811
Cardiovascular Diseases, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary heart disease, Heart failure, Chronic Kidney DiseasesDeregulated Nutrient SensingPatients with CKD were significantly more likely to be older, to have atherogenic dyslipidemia and a history of cardiovascular diseases (coronary heart disease, prior myocardial infarction, heart failure) (p < 0.01).18702327
Diabetes Mellitus, Non-Insulin-Dependent, metabolic disturbance, ObesityDeregulated Nutrient SensingIndividuals with obesity and/or metabolic disturbances (insulin resistance and type 2 diabetes) have increased plasma ASP.18702682
ObesityDeregulated Nutrient SensingIn addition, exercise participation, even in the absence of difference in physical fitness, may be protective against development of central obesity and insulin resistance in this understudied Korean population.18702942
Metabolic Syndrome XDeregulated Nutrient SensingThese data suggest that fetuin-A might be a regulator of insulin resistance and/or metabolic syndrome.18702951
Hypertension, CTCAE, Kidney DiseasesDeregulated Nutrient SensingIs there a link between insulin resistance and chronic kidney disease in men with treated hypertension?18703873
CachexiaDeregulated Nutrient SensingThe current findings indicated that subcutaneous WAT does not contribute to the systemic inflammatory reaction and does not induce adipocyte insulin resistance in cancer cachexia.18704987
HaploinsufficiencyDeregulated Nutrient SensingAberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.18708577
Malignant neoplasm of prostateDeregulated Nutrient SensingWe report here that Rheb GTPase, the upstream activator of the mTOR complex 1 (mTORC1) is amplified in human prostate cancers.18708577
Aggressive Non-Hodgkin LymphomaDeregulated Nutrient SensingWe find that Rheb, a proximal activator of mTORC1, can produce rapid development of aggressive and drug-resistant lymphomas.18708578
LymphomaDeregulated Nutrient SensingNotably, RHEB is highly expressed in some human lymphomas, resulting in mTORC1 activation and increased sensitivity to rapamycin and FTI.18708578
Primary malignant neoplasmDeregulated Nutrient SensingIn summary, the Rheb GTPase is an oncogenic activity upstream of mTORC1 and eIF4E and a direct therapeutic target of farnesyltransferase inhibitors in cancer.18708578
Proteinuria, Kidney Failure, Chronic, Dyslipidemias, Anemia, Chronic Kidney DiseasesDeregulated Nutrient SensingTimely recognition of risk factors for CKD progression and their treatment by correction of high blood pressure, reduction of proteinuria, correction of anaemia and dyslipidaemia (to lower cardiovascular risk) may retard progression of CKD to end-stage renal disease, thus delaying the need for renal replacement therapy.18709007
Obesity, Dyslipidemias, Chronic disease, Diabetes MellitusDeregulated Nutrient SensingThese changes can induce a significant increase in the prevalence of some chronic diseases, such as obesity, dyslipidemia, and diabetes mellitus.18710332
AtherosclerosisDeregulated Nutrient SensingSelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.18710632
Endothelial dysfunctionDeregulated Nutrient SensingPerivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction.18712517
DyslipidemiasDeregulated Nutrient SensingPPARG mutations may cause insulin resistance and dyslipidemia, but little is known about the mechanisms of the abnormalities of lipid metabolism.18713822
Prediabetes syndrome, Insulin Secretion, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingUsing our thoroughly phenotyped cohort of subjects at an increased risk for type 2 diabetes, we assessed the association of the nine latest genetic variants with the predominant prediabetes traits, i.e., obesity, impaired insulin secretion, and insulin resistance.18714373
Malignant neoplasm of skinDeregulated Nutrient SensingCollectively, we conclude that AMPK contributes to UV- and H(2)O(2)-induced apoptosis via multiple mechanisms in human skin keratinocytes and AMPK plays important roles in UV-induced signal transduction ultimately leading to skin photoaging and even skin cancer.18715874
Inflammation, Cachexia, AnorexiaDeregulated Nutrient SensingAnorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia.18718696
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIf an individual was diagnosed with diabetes, hypertension, or dyslipidemia, each item was recorded as a positive finding.18719340
Liver DysfunctionDeregulated Nutrient SensingCommon SNPs in ADIPOR2 are associated with LFT in T2DM subjects, which suggests a possible role of this receptor in liver dysfunction associated with insulin resistance.18719649
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was strong association between diabetes mellitus and dyslipidaemia (P < 0.05).18720629
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn regression analysis, diabetes was the second most important factor after obesity in secondary dyslipidaemia.18720629
Diabetes MellitusDeregulated Nutrient SensingRecently, we found that soluble CD36 is increased in plasma from patients with diabetes strongly correlated with insulin resistance.18723424
Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingRisk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes.18752331
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAlterations in glucose metabolism and insulin resistance in subjects with normal ALT should also be considered in the selection of NAFLD cases for histological assessment of disease severity and progression.18752331
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study demonstrates that 48 hours of bed rest has no significant effect on insulin resistance or standard metabolic variables in normal subjects and patients with type 2 diabetes.18753098
Platelet Glycoprotein IV Deficiency, Hypertriglyceridemia, Hypertension, CTCAEDeregulated Nutrient SensingPatients with CD36 deficiency (CD36-D) have postprandial hypertriglyceridemia, insulin resistance, and hypertension.18753675
Dyslipidemias, OverweightDeregulated Nutrient SensingFor patients with T1DM, being overweight was associated with higher blood pressure and dyslipidemia.18753706
Hypertriglyceridemia, Dyslipidemias, Hypercholesterolemia, FamilialDeregulated Nutrient SensingThe prevalences of hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, impaired glucose tolerance (IGT), and WCH were similar to excess weight in that they increased significantly until the seventh decade of life and decreased thereafter significantly (P < 0.05 in most steps).18753728
Demographics Domain, Hypertriglyceridemia, Dyslipidemias, Haiti, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE, Hypercholesterolemia, FamilialDeregulated Nutrient SensingOn the other hand, the prevalences of hypertension (HT), diabetes mellitus (DM), and coronary heart disease (CHD) always increased significantly with age without any decrease (P < 0.05 in most steps), indicating their irreversibility in contrast to the reversibility of excess weight, hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, IGT, and WCH.18753728
Cardiovascular DiseasesDeregulated Nutrient SensingC-reactive protein, insulin resistance and risk of cardiovascular disease: a population-based study.18753952
Inflammation, Metabolic DiseasesDeregulated Nutrient SensingC-reactive protein (CRP), a marker of inflammation, and insulin resistance (IR), a metabolic disorder, are closely related.18753952
Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity in males and insulin resistance in females were prevalent in children who were at elementary school level.18756035
Biliary calculiDeregulated Nutrient SensingInsulin resistance is associated with gallstones even in non-obese, non-diabetic Korean men.18756051
Biliary calculi, Obesity, Diabetes MellitusDeregulated Nutrient SensingIt remains unclear as to whether insulin resistance alone or in the presence of wellknown risk factors, such as diabetes or obesity, is associated with gallstones in men.18756051
Cholelithiasis, ObesityDeregulated Nutrient SensingThe aim of this study was to determine whether insulin resistance is associated independently with gallstone disease in non-diabetic men, regardless of obesity.18756051
Biliary calculi, ObesityDeregulated Nutrient SensingInsulin resistance was positively associated with gallstones in non-diabetic Korean men, and this occurred regardless of obesity.18756051
Biliary calculiDeregulated Nutrient SensingGallstones appear to be a marker for insulin resistance, even in non-diabetic, nonobese men.18756051
Dyslipidemias, atherosclerotic, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingAlthough previous studies suggest that treatment of dyslipidemia with statins reduces mortality and morbidity that are associated with cardiovascular disease, only a few studies have examined the efficacy of statins on atherosclerotic status in patients with chronic kidney disease (CKD).18758125
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIdentifying health-related quality of life (HRQL) domains for multiple chronic conditions (diabetes, hypertension and dyslipidemia): patient and provider perspectives.18759755
methyldopa, Inflammation, Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingThis finding may suggest that pathogenic processes linking to wider venular caliber be shared by early AMD and common cardiovascular risk factors such as inflammation, dyslipidemia, and endothelial dysfunction.18760764
diabeticDeregulated Nutrient SensingIn subgroup analysis, Japanese obese diabetic -2518AA carriers had a higher MCP-1 concentration and increased insulin resistance than obese diabetic -2518G carriers.18762729
Cardiomyopathy, Familial Idiopathic, MyocardialDeregulated Nutrient SensingTrimetazidine improved whole-body insulin sensitivity and glucose control in these insulin-resistant idiopathic dilated cardiomyopathy patients, thus hypothetically countering the myocardial damage of insulin resistance.18765391
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingPrevalence and particularities of dyslipidaemia in subjects with coronary heart disease.18767409
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe purpose of the study was to evaluate the lipid profile and the prevalence of dyslipidaemia and other risk factors in subjects with and without coronary heart disease.18767409
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidaemia was higher in group 1 than in group 2 (91.2% vs. 85.3%; p = 0.01).18767409
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe study found a high prevalence of dyslipidaemia in Romanian patients with coronary heart disease.18767409
Weight decreased, Increased insulin level, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingWe also observed marked weight loss and resolution of hypertension, dyslipidemia and hyperinsulinemia.18769731
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingKnown risk factors like dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile.18769801
Beta-cell dysfunctionDeregulated Nutrient SensingThe results do not support beneficial effects of CLA/n-3 LC-PUFA for beta-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced.18772894
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia, especially low HDL cholesterol, in Iranian adults is very high.18774906
Diabetes MellitusDeregulated Nutrient SensingElevated C-reactive protein (CRP), IL-6 and retinol-binding protein 4 (RBP4) levels are associated with insulin resistance and diabetes mellitus.18775100
Diabetic KetoacidosisDeregulated Nutrient Sensingthat culminated in emergency treatment for diabetic ketoacidosis secondary to severe insulin resistance.18775978
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of type 2 diabetes and glucose intolerance was 5.55- and 1.90-fold higher, respectively, in Uygur than in the Kazak population (8.16 vs. 1.47%, P < 0.001 and 3.29 vs. 1.73%, P < 0.001).18777166
Chronic heart failureDeregulated Nutrient SensingReduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition.18778861
Chronic heart failure, Congestive heart failureDeregulated Nutrient SensingIn chronic heart failure (CHF) skeletal muscle insulin resistance occurs independently of etiology and contributes to impaired energy metabolism.18778861
Congestive heart failureDeregulated Nutrient SensingLow skeletal muscle GLUT4 contributes to insulin resistance in CHF.18778861
ObesityDeregulated Nutrient SensingFructose-1,6-bisphosphatase (FBPase) is a regulated enzyme in gluconeogenesis that is increased in animal models of obesity and insulin resistance.18780768
Diabetes Mellitus, Breast Carcinoma, Cardiovascular DiseasesDeregulated Nutrient SensingIn postmenopausal women, an increase in insulin resistance is associated with an increased risk of diabetes, cardiovascular disease and breast cancer.18781481
Diabetes MellitusDeregulated Nutrient SensingHormone replacement therapy (HRT) can reduce insulin resistance and coffee use is reported to decrease the incidence of diabetes.18781481
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance is directly related to body mass index (p < 0.0001), and not with age and blood pressure; hypertensive menopausal women have a slightly higher body mass index but the same degree of insulin resistance as normotensive women.18781481
Hypertension, CTCAEDeregulated Nutrient SensingWomen on HRT show lower insulin resistance, but not lower prevalence of arterial hypertension.18781481
Obesity, Diabetes MellitusDeregulated Nutrient SensingSHP mutations may also be associated with later obesity and insulin resistance syndrome that induces diabetes.18781616
Obesity, Diabetes MellitusDeregulated Nutrient SensingTo determine how serum concentrations of resistin are distributed in humans in relation to insulin resistance, type 2 diabetes, and obesity.18789551
Obesity, AbdominalDeregulated Nutrient SensingIn this population resistin is inversely associated with insulin resistance and abdominal obesity.18789551
Diabetes MellitusDeregulated Nutrient SensingPEDF may play a protective role against hepatic insulin resistance in diabetes.18792873
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is characterized by a combination of insulin resistance, dyslipidemia, and increased blood pressure.18793563
Migraine Disorders, Dyslipidemias, Diabetes Mellitus, pyruvate synthase activity, Hypertension, CTCAEDeregulated Nutrient SensingThe observed lack of association between PFO and migraine (with or without aura) was not modified by diabetes mellitus, hypertension, cigarette smoking, or dyslipidemia.18794393
Immunologic Deficiency Syndromes, HIV-1 Infection PathwayDeregulated Nutrient SensingKwon et al studying HIV-1 infection and subsequent immune deficiency process demonstrated that HIV-1 Tat protein binds to SIRT1 protein, a well-known longevity factor, and inhibits the SIRT1-mediated deacetylation of the p65 component of the NF-kappaB complex.18800364
LongevityDeregulated Nutrient SensingLongevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF-kappaB signaling, the major outcome of which is inflamm-aging via proinflammatory responses.18800364
Diabetes MellitusDeregulated Nutrient SensingClinical measures of physical fitness predict insulin resistance in people at risk for diabetes.18801854
Diabetes MellitusDeregulated Nutrient SensingClinical measures of physical fitness can predict insulin resistance in people at risk for diabetes.18801854
Diabetes MellitusDeregulated Nutrient SensingThe findings support the validity of clinical measures of physical fitness for predicting insulin resistance in people at risk for diabetes.18801854
Hypertension, CTCAEDeregulated Nutrient SensingAccumulating evidence suggests that insufficient oxidative capacity plays a central role in the development of insulin resistance and, perhaps, hypertension.18802433
HyperthyroidismDeregulated Nutrient SensingPlasma visfatin levels were not associated with indicators of insulin resistance in hyperthyroid patients.18803942
Bronchopulmonary Dysplasia, ObesityDeregulated Nutrient SensingBiliopancreatic diversion (BPD) is a surgical procedure performed in patients with untreatable obesity and insulin resistance.18803943
Hypertensive (finding), Glucose Intolerance (disease)Deregulated Nutrient SensingEffects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance.18803955
Hypertensive (finding), Glucose Intolerance (disease)Deregulated Nutrient SensingTelmisartan decreased body weight while increasing serum adiponectin levels in hypertensive patients with glucose intolerance.18803955
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone is a peroxisome proliferator-activated receptor-gamma agonist that decreases insulin resistance in type 2 diabetes mellitus.18803990
Inflammation, HypertriglyceridemiaDeregulated Nutrient SensingThese data confirm impaired metabolism of fat among smokers and suggest that mechanisms other than inflammation or insulin resistance may explain the observed hypertriglyceridemia among smokers.18804210
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population.18804306
Dyslipidemias, ObesityDeregulated Nutrient SensingT2DM appears to be heritable in South East Asians with excess maternal transmission of obesity, IR and dyslipidemia.18804306
Retroviridae Infections, Pancreatitis, Dyslipidemias, Biliary calculiDeregulated Nutrient SensingEpisodes of pancreatitis were associated with alcohol consumption in 62% of cases and with gallstones in 14%; 4% of cases were associated with both gallstones and alcohol consumption, 8% with dyslipidaemia and 5% with retroviral disease.18807304
Vascular Diseases, Dyslipidemias, Coronary Artery Disease, Cerebrovascular accidentDeregulated Nutrient SensingVascular disease remains the prime contributor to the pathogenesis of stroke, but dyslipidemia has not been clearly established as a risk factor for stroke the same way it has been for coronary artery disease.18807425
Hypertension, CTCAEDeregulated Nutrient SensingThere was a significant interaction between age and WC indicating that the relation between WC with insulin resistance, high CRP, and hypertension was attenuated in older adults.18809302
Atherosclerosis, diabeticDeregulated Nutrient SensingMeasures of cardiovascular risk, body composition, and serum hormones from the baseline examinations of the Insulin Resistance Atherosclerosis Study on 524 nondiabetic women, 258 diabetic women, 421 nondiabetic men, and 220 diabetic men were compared to detect greater adverse differences in women than in men.18809621
Injury of liver, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingTherapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study.18813860
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality.18813860
Liver diseases, Ancriviroc, Non-alcoholic Fatty Liver Disease, Obesity, DiseaseDeregulated Nutrient SensingWe analyzed the incidence of obesity, insulin resistance, and other disorders in patients with NAFLD (Group A), CH-C (Group B), or other liver diseases (Group C).18813860
Troponin I Type 2 MeasurementDeregulated Nutrient SensingDoes AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?18815486
Atrophic, Troponin I Type 2 MeasurementDeregulated Nutrient SensingHere, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.18815486
ObesityDeregulated Nutrient SensingThese alterations in the 24-hour circadian patterns of BP were related to the degree of obesity and insulin resistance.18816210
Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing78.4% of the patients had dyslipidemia and 32.3% diabetes.18817699
ObesityDeregulated Nutrient SensingPatients with poorly compensated type 2 DM (HbAc1 > 7%) and DSF were given IIT corrected with regard for obesity and insulin resistance (IR).18819351
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBut the risk of MI increases with age, smoking, hypertension, dyslipidemia and diabetes.18819701
TriglyceridesDeregulated Nutrient SensingHigher levels of sICAM-1 were independently associated with higher BMI, higher triglycerides, and lower insulin resistance (P < 0.001).18820652
Alcoholic Intoxication, Chronic, Dyslipidemias, Myocardial Infarction, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingNineteen (48.5%) patients had hypertension, eight (20.5%) had history of smoking, six (15.5%) had history of alcoholism, eight (20.5%) had dyslipidemia, two (5.0%) had diabetes and one (2.56%) had myocardial infarct previously.18820790
Coronary heart diseaseDeregulated Nutrient Sensing[Relation of phlegm-stasis syndrome with insulin resistance and monocyte PPARgamma mRNA expression in patients with coronary heart disease].18822908
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo explore the relation of phlegm-stasis syndrome with insulin resistance and monocyte peroxisome proliferator activated receptor-gamma messenger ribonucleic acid (PPARgamma mRNA) expression in patients with coronary heart disease (CHD).18822908
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingChanges of insulin resistance and PPARgamma mRNA expression in monocytes are possibly one of the mechanisms for the development of phlegm-stasis syndrome in CHD.18822908
InflammationDeregulated Nutrient SensingInsulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women.18825363
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingAkt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity.18826227
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone versus rosiglitazone treatment in patients with type 2 diabetes and dyslipidemia: cost-effectiveness in the US.18826750
DyslipidemiasDeregulated Nutrient SensingBaseline parameters came from a multi-center, double-blind trial comparing lipid and glycemic effects of pioglitazone (n = 400) and rosiglitazone (n = 402) among individuals with T2DM and untreated dyslipidemia.18826750
DyslipidemiasDeregulated Nutrient SensingNevertheless, pioglitazone (when compared to rosiglitazone) was found to have long-term value as a treatment option for T2DM patients with dyslipidemia treated within the US payer setting.18826750
HyperinsulinismDeregulated Nutrient SensingIt is not known whether there is also a sex difference in the association between hyperinsulinaemia, reflecting insulin resistance, and CVD.18829029
Hyperinsulinism, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingIn parallel with diabetes, fasting hyperinsulinaemia reflecting insulin resistance in non-diabetic subjects is associated with an increased risk for cardiovascular disease, which is more pronounced in women than in men.18829029
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAlthough the former was only influenced by age, dyslipidaemia and diabetes mellitus influenced the latter.18830251
Hyperuricemia, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIn addition, dyslipidaemia, hyperuricaemia and diabetes associated with higher OR for hypertension in Minnan women.18830252
Glucose Intolerance (disease), Sleep disturbancesDeregulated Nutrient SensingLiver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients.18832089
Increased insulin level, IGHD1-7 geneDeregulated Nutrient SensingDM1 predisposes insulin resistance and compensatory hyperinsulinemia exist even in patients with low FBS.18834994
Glucose Intolerance (disease), Myotonic DystrophyDeregulated Nutrient SensingA cross-sectional study for glucose intolerance of myotonic dystrophy.18834994
Glucose Intolerance (disease), IGHD1-7 geneDeregulated Nutrient SensingWe should pay attention to glucose intolerance of DM1 patients earlier than that of the general population.18834994
NeoplasmsDeregulated Nutrient SensingWe demonstrate that Sirt1(+/-);p53(+/-) mice develop tumors in multiple tissues, whereas activation of SIRT1 by resveratrol treatment reduces tumorigenesis.18835033
Malignant NeoplasmsDeregulated Nutrient SensingFinally, we show that many human cancers exhibit reduced levels of SIRT1 compared to normal controls.18835033
NeoplasmsDeregulated Nutrient SensingThus, SIRT1 may act as a tumor suppressor through its role in DNA damage response and genome integrity.18835033
Refractory anemias, Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia has been described in non-treated rheumatoid arthritis (RA), and improves after therapy with disease modifying anti-rheumatic drugs or glucocorticoids; however, it has generally been perceived that glucocorticoids adversely affect lipid metabolism.18837746
Cardiac complication, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCentral fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications.18838980
Atherosclerosis, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary heart disease, Cerebral Atherosclerosis, Chronic Kidney DiseasesDeregulated Nutrient SensingPatients with CKD were significantly more likely to be older, to have atherogenic dyslipidemia and clinical manifestations of atherosclerosis (coronary heart disease, prior myocardial infarction and cerebral atherosclerosis).18839606
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals.18840623
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingOur results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension.18840623
Glucose Intolerance (disease), Kidney FailureDeregulated Nutrient SensingNo adverse effects, such as renal failure or glucose intolerance, were seen.18845408
Inflammation, ObesityDeregulated Nutrient SensingObesity could also directly and positively affect blood pressure (B = 0.51, P < 0.001), without the mediation of insulin resistance and/or inflammation.18846046
Glucose Intolerance (disease), Hypertension, CTCAE, Pre-EclampsiaDeregulated Nutrient SensingThese results suggest that insulin resistance and relative glucose intolerance are associated with an increased risk of new-onset hypertension in pregnancy, particularly preeclampsia, and support the hypothesis that insulin resistance may play a role in the pathogenesis of this disorder.18847384
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingTransient hypertension of pregnancy, the new-onset nonproteinuric hypertension of late pregnancy, is associated with a high risk of later essential hypertension and glucose intolerance; thus, these conditions may have a similar pathophysiology.18847384
ObesityDeregulated Nutrient SensingTo study insulin resistance and parental obesity as predictors of improvement in weight status in obese children and adolescents undergoing therapeutic life change intervention (TLC).18848671
FailedDeregulated Nutrient SensingFailing to respond to standard therapeutic lifestyle change intervention was dependent on baseline insulin resistance, and parental obesity-related comorbidity.18848671
Fatty Liver, ObesityDeregulated Nutrient SensingLiver biopsy of the apoB-13.7 heterozygote, which had obesity and insulin resistance, showed severe fatty liver.18848826
glucose metabolismDeregulated Nutrient SensingPreoperative administration of oral carbohydrate-rich solutions: Comparison of glucometabolic responses and tolerability between patients with and without insulin resistance.18849145
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, our data indicate that RBP4 levels in plasma, skeletal muscle, and fat may be linked to insulin resistance and type 2 diabetes in a secondary and noncausal manner.18852328
DyslipidemiasDeregulated Nutrient SensingPatterns of dyslipidemia were higher in subjects diagnosed with insulin resistance.18852934
Hypertriglyceridemia, HypoalphalipoproteinemiasDeregulated Nutrient SensingInsulin resistance associated with hypertriglyceridemia and hypoalphalipoproteinemia was common among our studied population.18852934
Hypoalphalipoproteinemias, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingIn addition, 36.8% of the obese individuals (as measured by waist perimeter) had hypertriglyceridemia/hypoalphalipoproteinemia, 35.2% had mixed dyslipidemia, and 33.4% had hypertriglyceridemia.18852934
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes.18854016
Cardiovascular DiseasesDeregulated Nutrient SensingRecent studies reported that retinol-binding protein 4 (RBP4) has a causal role in insulin resistance and suggested that its circulating levels may predict cardiovascular disease.18854400
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAt baseline, all patients had normal insulin levels, C-peptide, and homeostatic model assessment of insulin resistance index, except for one female diagnosed with type 2 diabetes.18854428
Weight GainDeregulated Nutrient SensingWe conclude that, in leptin-deficient adults, the interruption of r-metHuLeptin decreases insulin resistance in the context of rapid weight gain.18854428
Hyperleucinemia, ObesityDeregulated Nutrient SensingOur results suggest that hyperleptinemia may contribute to mediate the increased insulin resistance of obesity.18854428
Hypertensive (finding), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease, adiponectin and insulin resistance in dipper and nondipper essential hypertensive patients.18854760
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial, and the presence of insulin resistance is recognized as the pathophysiological hallmark of this condition.18854760
Hypertension, CTCAEDeregulated Nutrient SensingArterial hypertension is referred as an insulin-resistant state, and insulin resistance may substantially contribute to the cardiovascular risk in this disorder.18854760
Steatohepatitis, Hypertensive (finding), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn the absence of major risk factors for the development of NAFLD, a high prevalence of liver steatosis was associated with insulin resistance and low adiponectin levels in essential hypertensive patients with a nondipping profile.18854760
Diabetes MellitusDeregulated Nutrient SensingUrinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance.18854761
Dyslipidemias, OverweightDeregulated Nutrient SensingMost poorly documented was history of dyslipidaemia (53%) and obesity/ overweight (2%).18855517
Prediabetes syndrome, Dyslipidemias, diabeticDeregulated Nutrient SensingDyslipidaemia is present not only in diabetic but also in prediabetic subjects.18922596
Myositis, CTCAE 5.0Deregulated Nutrient SensingDecreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.18922603
amyloid-beta bindingDeregulated Nutrient SensingExperimentally, increased activity of SIRT1 facilitates calorie-restricted longevity, and decreases NF-kappaB activation and the amount of the amyloid-beta (Abeta).18922603
Myopathy, Myositis, CTCAE 5.0Deregulated Nutrient SensingWe studied SIRT1 in an aging-associated muscle disease, sporadic inclusion-body myositis (s-IBM), whose muscle fibers contain increased NF-kappaB activation and abnormal accumulation of Abeta.18922603
DiseaseDeregulated Nutrient SensingTo our knowledge, this is the first demonstration of SIRT1 abnormalities, including decreased SIRT1 deacetylase activity, in human disease associated with aging.18922603
ObesityDeregulated Nutrient SensingInsulin resistance and obesity are recognized as left ventricular (LV) mass determinants independent of blood pressure (BP).18929416
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHigher levels of education were associated with lower prevalences of diabetes and current smoking in both genders and lower prevalences of hypertension and dyslipidemia in women.18929705
Diabetes MellitusDeregulated Nutrient SensingSeveral lines of evidence support the notion that elevated blood viscosity may predispose to insulin resistance and type 2 diabetes mellitus by limiting delivery of glucose, insulin, and oxygen to metabolically active tissues.18931370
Diabetes MellitusDeregulated Nutrient SensingTherefore, elevated blood viscosity and hematocrit deserve attention as emerging risk factors for insulin resistance and type 2 diabetes mellitus.18931370
Hypertension, CTCAE, Depression, CTCAE, DyslipidemiasDeregulated Nutrient SensingShe enjoyed complete independence in all activities of daily living, although she had essential hypertension, dyslipidemia, mild depression and urinary frequency.18935752
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension is common among patients with dyslipidemia but is often poorly treated.18937013
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIn this clinical trial of dyslipidemia management, inadequately controlled hypertension was common, occurring in nearly 50% of individuals.18937013
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe dyslipidemia and insulin resistance of type 2 diabetes mellitus can be improved by aerobic exercise, but effects on LDL kinetics are unknown.18940401
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevalence of dyslipidemia in patients with type 2 diabetes in Jordan.18946566
Dyslipidemias, Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine the frequency and patterns of dyslipidemia in patients with type 2 diabetes mellitus (DM) and to estimate the effects of sociodemographic and clinical variables on dyslipidemia.18946566
DyslipidemiasDeregulated Nutrient SensingOver 90% of patients with type 2 DM had one or more types of dyslipidemia.18946566
Triglycerides, DyslipidemiasDeregulated Nutrient SensingThe most common dyslipidemia in our study was high LDL-cholesterol and high triglycerides as reported in the literature.18946566
Diabetes MellitusDeregulated Nutrient SensingWe hypothesised that proinsulin and insulin resistance contributes to an increase of risk for fatal and non-fatal stroke/TIA, independently of diabetes and established risk factors.18949454
Obesity, Abdominal, Dyslipidemias, Coronary heart disease, Cerebrovascular accident, Hypertension, CTCAEDeregulated Nutrient SensingHigh risk (HR) was defined as having 3-5 factors: abdominal obesity, BMI >or= 28 kg/m2, dyslipidemia, hypertension, coronary heart disease, or stroke.18954500
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, AtherosclerosisDeregulated Nutrient SensingThe aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients.18955782
HyperferritinaemiaDeregulated Nutrient SensingHyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overload.18958176
Steatohepatitis, Hemochromatosis, HyperferritinaemiaDeregulated Nutrient SensingThe present results suggest that liver steatosis and insulin resistance but not increased iron load is frequently seen in patients referred for suspected hemochromatosis on the basis of hyperferritinemia.18958176
Diabetes MellitusDeregulated Nutrient SensingAdiponectin is an adipocyte hormone that ameliorates insulin resistance and prevents diabetes.18971537
Anxiety, CTCAE 3.0, Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingAnxiety symptoms were associated with depressive symptoms (OR 5.49, 95%CI 2.89-10.43) and negatively associated with dyslipidemia (OR 0.48, 95%CI 0.25-0.94).18972905
DyslipidemiasDeregulated Nutrient SensingAssessment of the efficacy and tolerability of a fixed dose combination of atorvastatin 10 mg + metformin SR 500 mg in diabetic dyslipidaemia in adult Indian patients.18975505
Dyslipidemias, diabeticDeregulated Nutrient SensingA new fixed dose combination containing atorvastatin 10 mg + metformin SR 500 mg is being introduced in the Indian market for the treatment of dyslipidaemia in diabetic patients.18975505
DyslipidemiasDeregulated Nutrient SensingIn conclusion, the results of the present study suggest that, the fixed dose combination of atorvastatin 10 mg + metformin SR 500 mg is efficacious and well tolerated therapeutic modality in patients with diabetic dyslipidaemia.18975505
DyslipidemiasDeregulated Nutrient SensingFurthermore this combination offers dosage convenience to the patient and by virtue of its dual mode of action is a useful addition to the therapeutic armamentarium for patients with diabetic dyslipidaemia.18975505
Diabetes MellitusDeregulated Nutrient SensingInsufficient renal 1-alpha hydroxylase and bone homeostasis in aged rats with insulin resistance or type 2 diabetes mellitus.18979155
Diabetes MellitusDeregulated Nutrient SensingHydrochlorothiazide, but not Candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation: the mechanisms for the diabetes preventing effect of Candesartan (MEDICA) Study.18981327
palladium, Left Ventricular Hypertrophy, DyslipidemiasDeregulated Nutrient SensingDyslipidemia often occurs in PD but it remains unclear whether dyslipidemia is related to LVH.18981390
Dyslipidemias, Pathologic Intimal ThickeningDeregulated Nutrient SensingStudy of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia.18982922
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe etiology and pathogenesis of type 2 diabetes mellitus (T2DM) are not completely understood although it is often associated with other conditions such as obesity, hypertension, and dyslipidemia.18985010
Diabetes MellitusDeregulated Nutrient SensingThis result supports the importance of impaired antioxidant status for the development of insulin resistance and type 2 diabetes.18985315
Steatohepatitis, Sleep Apnea, Obstructive, ObesityDeregulated Nutrient SensingObstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity.18990675
Sleep Apnea, Obstructive, Injury of liverDeregulated Nutrient SensingObstructive sleep apnea is associated with insulin resistance and liver injury.18990675
Steatohepatitis, Apnea, ObesityDeregulated Nutrient SensingIt is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity.18990675
Respiratory disturbancesDeregulated Nutrient SensingThere was no relationship between the respiratory disturbance index and insulin resistance or liver histopathology.18990675
Steatohepatitis, Sleep Apnea, CTCAE, ObesityDeregulated Nutrient SensingHypoxic stress of sleep apnea may be implicated in the development of insulin resistance and steatohepatitis in severe obesity.18990675
Obesity, Abdominal, Cardiovascular DiseasesDeregulated Nutrient SensingAn increment in the androgenic milieu that correlates with abdominal fat, insulin resistance and atherogenic lipoproteins becomes evident after the menopausal transition and suggests that evaluation of cardiovascular disease risk in these women should include androgens, considering that abdominal obesity is one of the main determinants of the relationship between androgenic parameters and cardiovascular risk factors.18991078
DyslipidemiasDeregulated Nutrient SensingIn patients with mixed dyslipidemia, combination therapy with ABT-335+rosuvastatin resulted in more effective control of multiple lipid parameters than either monotherapy alone, with a safety profile similar to both monotherapies.18996523
DyslipidemiasDeregulated Nutrient SensingThis combination may be an appropriate therapeutic option to treat mixed dyslipidemia.18996523
Congenital adrenal hyperplasiaDeregulated Nutrient SensingMetformin, an agent known to reduce insulin resistance, further suppressed the 17-hydroxyprogesterone concentration in a patient with classic congenital adrenal hyperplasia on steroid replacement therapy.18996819
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingThe adiponectin level has been linked to insulin resistance, dyslipidemia and coronary artery disease.19000491
Autoimmune Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Kidney FailureDeregulated Nutrient SensingOur conclusions are that 1) the need for insulin treatment in LADA is linked to the degree of autoimmunity and beta-cell failure, 2) subjects with LADA and type 2 diabetes without the need for insulin treatment are phenotypically similar, and 3) insulin treatment in type 2 diabetic patients is associated with both insulin resistance and beta-cell insufficiency.19001190
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA novel adipokine, retinol binding protein-4 (RBP4), was reported to be associated with insulin resistance and the prevalence of type 2 diabetes.19003725
Glucose Intolerance (disease), Sleep Apnea, Obstructive, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThis study indicates that plasma RBP4 is associated with dyslipidemia, but not with insulin resistance, glucose intolerance, or hypertension in patients with OSAS.19003725
Glucose Intolerance (disease), Obesity, VisceralDeregulated Nutrient SensingIt is concluded that low SHBG concentrations may indicate visceral obesity and glucose intolerance in premenopausal women.19008614
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingHypertensive patients presented lower improvement in QOL scores when compared to non-hypertensive ones [8.3(0-25) vs. 16.6(0-33.3); P=0.05], as well as patients with dyslipidemia, when compared to non-dyslipidemic ones [8.3(0-25) vs. 16.6(0-33.3); P=0.02].19009175
Impaired T cell functionDeregulated Nutrient SensingThe pathophysiology of IFG-IGT (having both B-cell dysfunction and insulin resistance) indicates that it may be a different entity and not be included in IGT.19010062
CAV1 gene, DyslipidemiasDeregulated Nutrient SensingAt multivariate analysis, dyslipidemia was the most significant CVRF (P = .045) for the development of CAV.19010192
CAV1 gene, Dyslipidemias, HaitiDeregulated Nutrient SensingRecipient dyslipidemia is a risk factor for the development of CAV in HT.19010192
Dyslipidemias, HaitiDeregulated Nutrient SensingStatins, although the treatment of choice for dyslipidemia after heart transplantation (HT), are not always well tolerated or effective.19010194
Nonalcoholic Steatohepatitis, DyslipidemiasDeregulated Nutrient SensingEfficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia.19013295
Coronary Arteriosclerosis, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance (IR) is a risk factor for diabetes and atherosclerotic diseases.19013381
Dyslipidemias, Albuminuria, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingEstablishment of treatment goals for control of cardiovascular risk factors (blood pressure, dyslipidemia, diabetes mellitus,) and albuminuria to reduce the rate of progression of kidney disease.19018732
LipodystrophyDeregulated Nutrient SensingNo associations between insulin resistance and lipodystrophy or treatment regimen were detected.19018877
LipodystrophyDeregulated Nutrient SensingInsulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy.19018877
Menopause, Hypertension, CTCAE, physiopathologicalDeregulated Nutrient SensingMenopause, hypertension and abnormal stress tests were significantly more prevalent, adiponectin level was significantly decreased, CRP, insulin resistance, and EFT were significantly increased in women with microvascular dysfunction as compared with those without.19019370
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingNiacin is a preferred option for Lp(a) lowering in very-high-risk patients with coronary heart disease and dyslipidemia.19019811
AtherosclerosisDeregulated Nutrient SensingOne hundred and eighty-seven normolipidaemic, non-diabetic lean or obese subjects with or without insulin resistance participating in the Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk (SAPHIR) were included in the study.19021700
Inflammation, Diabetes MellitusDeregulated Nutrient SensingChronic low-grade inflammation has been associated with insulin resistance and type 2 diabetes.19022962
Inflammation, Diabetes MellitusDeregulated Nutrient SensingTherefore, these results show that CP can lower hsCRP, a marker of inflammation associated with insulin resistance and type 2 diabetes.19022962
Multiple Organ FailureDeregulated Nutrient SensingInsulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome.19025444
SepsisDeregulated Nutrient SensingInsulin resistance (IR) is a major factor in the pathogenesis of sepsis.19025444
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe prevalence of the main risk factors detected was: 39.3% overweight and 6.8% obese, mainly among men (60.4%), 41.8% for central obesity mainly among women (66.7%), 68% for dyslipidaemia and 15.4% for blood pressure alterations mainly among men (24.7%).19028731
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingIn total, 86% of the patients had hypertension, 43% had dyslipidaemia and 44% had a history of cardiovascular disease.19028750
Inflammation, AHSG protein, humanDeregulated Nutrient SensingFetuin-A, a protein almost exclusively secreted by the liver, induces insulin resistance and subclinical inflammation in rodents.19029462
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingAfter adjustment for age, sex, body mass index, diabetes mellitus, smoking, physical inactivity, dyslipidemia, previous cardiovascular diseases, serum creatinine level, and number of antihypertensive drugs in use, no office BP showed any prognostic value.19029499
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingApproximately two thirds of the participants (68%) had dyslipidemia, 79.9% hypertension, and 24% prior myocardial infarction.19033001
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingFood intake patterns associated with incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.19033409
Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study cohort included 880 middle-aged adults initially free of diabetes.19033409
Heart failureDeregulated Nutrient SensingThe beta2 adrenergic receptor Gln27Glu polymorphism affects insulin resistance in patients with heart failure: possible modulation by choice of beta blocker.19034036
Heart failureDeregulated Nutrient SensingInsulin resistance is prevalent in heart failure (HF) patients, and beta2 adrenergic receptors (beta2-AR) are involved in glucose homeostasis.19034036
Glucose Intolerance (disease), Pre-Gestational Diabetes, Cardiovascular DiseasesDeregulated Nutrient SensingThe offspring of mothers with pre-gestational type 1 diabetes (PGDM) may be at increased risk of glucose intolerance and cardiovascular disease in childhood.19034420
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAt cohort entry, the mean patient age was 65 years, 37.3% were male, 8.6% had diabetes, and 19.5% had dyslipidemia.19038916
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingMale gender, occurrence of cardiovascular disease during follow-up, and dyslipidemia were risk factors for CD.19038916
Muscle hypertrophy, Familial generalized lipodystrophy, Autosomal recessive inheritanceDeregulated Nutrient SensingBerardinelli-Seip congenital lipodystrophy (BSCL) is a rare autosomal recessive condition associating insulin resistance, absence of subcutaneous fat and muscular hypertrophy.19041432
Liver diseases, Alcoholic Intoxication, Chronic, Glucose Intolerance (disease), Malignant Neoplasms, HyperuricemiaDeregulated Nutrient SensingThe disease is frequently associated with alcoholism, hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways, requiring thorough clinical evaluation of all patients.19042074
Hypertension, CTCAE, ASAH1 wt Allele, DyslipidemiasDeregulated Nutrient SensingHypertension, dyslipidemia and impaired glucose metabolism were demonstrated in severe PHP, with improvement after surgery in these variables.19043371
Dyslipidemias, Albuminuria, Diabetes MellitusDeregulated Nutrient SensingTo explore the association between dyslipidaemia and albuminuria at the extreme of diabetes duration.19046204
Communicable Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA link between chronic hepatitis C virus (HCV) infection, Type 2 diabetes mellitus and insulin resistance has been suggested by several studies.19046205
Hepatitis C, Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingThese data suggest an association between HCV virus infection and the development of insulin resistance or diabetes mellitus without the typical features of the metabolic syndrome.19046205
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingA common functional ENPP1 K121Q polymorphism has been suggested to contribute to insulin resistance, obesity and type 2 diabetes (T2D) in various ethnic groups.19046915
Pulmonary arterial hypertension, Polycyclic Hydrocarbons, Aromatic, Cardiovascular Diseases, Dyslipidemias, ObesityDeregulated Nutrient SensingAlthough obesity, dyslipidemia and insulin resistance (IR) are well known risk factors for systemic cardiovascular disease, their impact on pulmonary arterial hypertension (PAH) is unknown.19047320
Pulmonary arterial hypertensionDeregulated Nutrient SensingInsulin resistance appears to be more common in pulmonary arterial hypertension females than in the general population, and may be a novel risk factor or disease modifier that might impact on survival.19047320
Weight decreasedDeregulated Nutrient SensingEnhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.19050176
Obesity, VisceralDeregulated Nutrient SensingControversy exists as to whether endogenous cortisol production is associated with visceral obesity and insulin resistance in humans.19050176
Weight decreasedDeregulated Nutrient SensingThese data support a model in which increased hypothalamic-pituitary-adrenal activity in men promotes selective visceral fat accumulation and insulin resistance and may promote weight regain after diet-induced weight loss, whereas 11beta-HSD-1 gene expression in SQF is a consequence rather than cause of adiposity.19050176
ETV3 wt AlleleDeregulated Nutrient SensingAmong individual MetS components, incident MI was independently associated with three of them: low high-density lipoprotein-cholesterol (OR = 2.03, CI = 1.09-3.78, P = 0.025) insulin resistance (OR = 2.02, CI = 1.08-3.78, P = 0.028) and increased albumin excretion rate (OR = 1.24, CI = 0.99-1.55, P = 0.060).19050451
Pancreatic carcinoma, ObesityDeregulated Nutrient SensingObesity and insulin resistance have been implicated in the etiology of pancreatic cancer (PC).19051043
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPreventing cardiovascular disease among Canadians: is the treatment of hypertension or dyslipidemia cost-effective?19052668
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingPlasma pre beta1-HDL levels have been reported to be increased in patients with coronary artery disease (CAD) and dyslipidemia.19054517
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingCoadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia.19057518
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship of serum gamma-glutamyltransferase to atherogenic dyslipidemia and glycemic control in type 2 diabetes.19057528
Hypercholesterolemia, Dyslipidemias, Hypertension, CTCAE, HyperuricemiaDeregulated Nutrient SensingAs GGT concentration increased, the association of BMI with atherogenic dyslipidemia and glycemic control strengthened (P = 0.01 and 0.004 for interactions, respectively); in contrast, the association of BMI with hypertension, hypercholesterolemia, and hyperuricemia did not change substantially across GGT quartiles.19057528
DyslipidemiasDeregulated Nutrient SensingFor example, within the lowest GGT quartile, BMI was not associated with atherogenic dyslipidemia or poor glycemic control, whereas in the highest GGT quartile, the prevalence rates ranged from 62.3 to 74.7% for dyslipidemia and from 75.3 to 83% for poor glycemic control.19057528
DyslipidemiasDeregulated Nutrient SensingIn conclusion, our findings show that BMI was associated with atherogenic dyslipidemia and poor glycemic control only when serum GGT activity was in its high-normal range.19057528
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThese findings suggest that obesity itself may not be a sufficient risk factor for atherogenic dyslipidemia or poor glycemic control in people with type 2 diabetes.19057528
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingFamilial hypertriglyceridemia (FHTG) is an uncommon primary (genetic) dyslipidemia.19057857
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn non-obese NAFLD patients: 1) although visceral fat was increased, insulin resistance and/or dysregulated secretion of adipocytokines was not necessarily shown; 2) intakes of total energy and carbohydrates were not excessive, although dietary cholesterol was superabundant and dietary PUFAs were significantly lower compared with those in obese patients; and 3) characteristic fat intake may be associated with the formation of NAFLD.19058085
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no significant difference in the percentage of patients with diabetes or dyslipidemia between the obese and non-obese groups.19058085
Dyslipidemias, Cholestasis, Intrahepatic CholestasisDeregulated Nutrient SensingNo appropriate pharmaceutical therapy has been established for dyslipidemia with cholestasis in progressive familial intrahepatic cholestasis (PFIC)-1.19059530
Dyslipidemias, Cholestasis, PruritusDeregulated Nutrient SensingBezafibrate treatment favorably affected pruritus, dyslipidemia, and cholestasis in PFIC-1.19059530
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingScreening for and management of dyslipidaemia are crucial in primary and secondary prevention of cardiovascular disease.19059566
Obesity, Diabetes MellitusDeregulated Nutrient SensingBecause E2 levels tend to be elevated in morbid obesity, insulin resistance, and diabetes, it is reasonable to hypothesize that high E2 levels are associated with MS in older men.19059904
Primary malignant neoplasmDeregulated Nutrient SensingConsistently with this, RNA interference-mediated knockdown of Sirt1, but not Sirt2, induced apoptosis in cancer cells.19060927
Primary malignant neoplasmDeregulated Nutrient SensingWe were finally able to ascribe the apoptotic effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1.19060927
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, dyslipidemia, and obesity were associated with lower scores in the physical domain.19061001
Sleep Disorders, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingSleeping disorders in type 2 diabetic patients constitute risk factors for aggravating diabetes since they can affect the metabolic control through insulin resistance syndrome.19061021
Erectile dysfunctionDeregulated Nutrient SensingTo determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls.19062003
Hypertension, CTCAEDeregulated Nutrient SensingCocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension.19064532
Hypertension, CTCAE, Endothelial dysfunctionDeregulated Nutrient SensingEssential hypertension is characterized by reciprocal relations between endothelial dysfunction and insulin resistance.19064532
Hypertension, CTCAE, Endothelial dysfunctionDeregulated Nutrient SensingThe objective was to test the hypothesis that consumption of cocoa may simultaneously lower blood pressure, improve endothelial dysfunction, and ameliorate insulin resistance in subjects with essential hypertension.19064532
Hypertension, CTCAEDeregulated Nutrient SensingDaily consumption of flavanol-rich cocoa for 2 wk is not sufficient to reduce blood pressure or improve insulin resistance in human subjects with essential hypertension.19064532
Esophageal Varices, Liver CirrhosisDeregulated Nutrient SensingInsulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis.19065558
Fibrosis Assessment, Hypertension, CTCAE, Liver StiffnessDeregulated Nutrient SensingWe tested the effectiveness of liver stiffness measurement (LSM) by transient elastography and the presence of insulin resistance (IR), a marker associated with fibrosis progression, in the noninvasive prediction of portal hypertension.19065558
Diabetes Mellitus, Obesity, Congenital AbnormalityDeregulated Nutrient SensingObesity and 2-type diabetes are well-known fetal malformation etiologies, due to insulin resistance.19065822
Somatotropin deficiencyDeregulated Nutrient SensingGH treatment in GH-deficient (GHD) patients may cause insulin resistance and exerts ambiguous effects on inflammatory markers.19067726
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingBeing overweight/obese is associated with hypertension and dyslipidemia.19072098
HypothyroidismDeregulated Nutrient SensingInsulin resistance is closely related to post-THW hypothyroidism in patients of DTC.19072673
DyslipidemiasDeregulated Nutrient SensingPatients whose GFR was <60 mL/min/1.73 m2 were older, prevalently female, had increased pulse pressure and higher prevalence of dyslipidaemia.19073656
Prostate carcinomaDeregulated Nutrient SensingRole of sirtuin histone deacetylase SIRT1 in prostate cancer.19075016
Structure of posterior cerebral arteryDeregulated Nutrient SensingOur data suggested that SIRT1, via inhibiting FOXO1 activation, could contribute to the development of PCa.19075016
Structure of posterior cerebral arteryDeregulated Nutrient SensingWe suggest that SIRT1 could serve as a target toward developing novel strategies for PCa management.19075016
Dyslipidemias, OverweightDeregulated Nutrient SensingTherefore, 86.1% (279) of cases with WCH were either overweight or obese, and 41.3% (134) of all WCH cases had dyslipidemia.19075483
Family historyDeregulated Nutrient SensingThese results indicate that insulin resistance and endothelial activation were found in normotensive adolescents with an FH.19078988
Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease), square decimeter, Diabetes MellitusDeregulated Nutrient SensingTo determine whether in the Mexican population the spouses of patients with type 2 diabetes mellitus (DM2) have an increased risk of any degree of glucose intolerance compared with spouses of subjects without diabetes.19080850
ObesityDeregulated Nutrient SensingInflammatory stimuli are causative for insulin resistance in obesity as well as in acute inflammatory reactions.19087258
Obesity, Diabetes MellitusDeregulated Nutrient SensingSerum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women.19088327
flavin-hypoxanthine dinucleotide, ObesityDeregulated Nutrient SensingThe objective of this study was to measure the independent association of serum adiponectin with FHD in relation to insulin resistance and obesity.19088327
flavin-hypoxanthine dinucleotideDeregulated Nutrient SensingThe relationship between adiponectin and FHD was similar between the high and low insulin resistance, BMI, and WC groups in male non-smokers and in all Korean women.19088327
flavin-hypoxanthine dinucleotide, ObesityDeregulated Nutrient SensingThese data also suggest that the association of serum adiponectin with FHD may be independent of obesity and insulin resistance.19088327
Peripheral Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia, smoking, sedentary lifestyle, and peripheral arterial disease were more frequent in men.19090879
Hyperinsulinism, Hepatitis C, ParesisDeregulated Nutrient SensingAs part of his hepatitis C infection, marked insulin resistance with hyperinsulinaemia was also present, exacerbating the paresis.19092328
Alopecia, CTCAEDeregulated Nutrient SensingAndrogenetic alopecia and insulin resistance in young men.19094069
Hypertension, CTCAE, Coronary Artery Disease, Androgenetic AlopeciaDeregulated Nutrient SensingEpidemiological studies have associated androgenetic alopecia (AGA) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance.19094069
pyruvate synthase activity, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients without PFO were more likely to be current smokers and obese and more frequently had a history of hypertension and dyslipidemia.19095992
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes.19097921
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalences of dyslipidemia and diabetes mellitus were 48% and 24%, respectively.19098372
Coronary Artery Disease, Coronary Lesions TreatedDeregulated Nutrient Sensing[Association among circulating endothelial progenitor cells, insulin resistance and severity of coronary lesions in patients with coronary artery disease].19100113
Coronary arteryDeregulated Nutrient SensingInsulin resistance/hyperinsulinemia could aggravate severity of coronary artery lesions via reducing the number and activities of circulating EPCs in patients with CAD.19100113
Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cerebrovascular accidentDeregulated Nutrient SensingAge, duration of atrial fibrillation, history of dyslipidemia and history of diabetes were the main risk factors related to stroke and the clustering of risk factors would further increase the risk.19103122
Hypertensive (finding), Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingHowever, few studies have assessed the benefits of cholesterol lowering for primary prevention of coronary heart disease in hypertensive patients with mild dyslipidemia or without conventional dyslipidemia.19104004
Data types - AddressDeregulated Nutrient SensingBecause sirtuins may increase the life span through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunoblots and in situ hybridization.19104446
Data types - AddressDeregulated Nutrient SensingWe report a significant reduction of SIRT1 (messenger RNA [mRNA], -29%; protein, -45%) in the parietal cortex of AD patients, but not in the cerebellum.19104446
Impaired cognition, Data types - AddressDeregulated Nutrient SensingFurther analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairment.19104446
Cessation of lifeDeregulated Nutrient SensingA significant relationship between SIRT1 levels and global cognition scores proximate to death was also found (r2= +0.09, p = 0.049).19104446
Data types - AddressDeregulated Nutrient SensingIn contrast, cortical SIRT1 levels remained unchanged in a triple-transgenic animal model of AD.19104446
amyloid-beta binding, Data types - AddressDeregulated Nutrient SensingCollectively, our results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD.19104446
Alzheimers DiseaseDeregulated Nutrient SensingSirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease.19104446
ObesityDeregulated Nutrient SensingOur results suggest that menopause-related insulin resistance, obesity and ethanol ingestion as well as menopause may contribute to an increase in level of serum urate in postmenopausal Japanese women.19105055
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes.19106274
Diabetes MellitusDeregulated Nutrient SensingIn this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes risk.19106274
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance.19106274
Obesity, Dyslipidemias, Metabolic Syndrome X, Bipolar DisorderDeregulated Nutrient SensingOur results suggest that the metabolic syndrome, in particular the obesity and dyslipidemia components, is predictive of depressive symptoms.19106378
ObesityDeregulated Nutrient SensingDecline in physical fitness from childhood to adulthood associated with increased obesity and insulin resistance in adults.19106381
ObesityDeregulated Nutrient SensingTo examine how fitness in both childhood and adulthood is associated with adult obesity and insulin resistance.19106381
ObesityDeregulated Nutrient SensingLower levels of child cardiorespiratory fitness were associated with increased odds of adult obesity (adjusted odds ratio [OR] per unit decrease 3.0 [95% CI 1.6-5.6]) and insulin resistance (1.7 [1.1-2.6]).19106381
ObesityDeregulated Nutrient SensingA decline in fitness level between childhood and adulthood was associated with increased obesity (4.5 [2.6-7.7]) and insulin resistance (2.1 [1.5-2.9]) per unit decline.19106381
ObesityDeregulated Nutrient SensingA decline in fitness from childhood to adulthood, and by inference a decline in physical activity, is associated with obesity and insulin resistance in adulthood.19106381
Obesity, AbdominalDeregulated Nutrient SensingIt has been hypothesized that abdominal obesity leads to insulin resistance partly through decreased adiponectin.19107128
Communicable Diseases, Hepatitis C, ObesityDeregulated Nutrient SensingThe clinical course of chronic hepatitis C virus (HCV) infection is strongly associated with insulin resistance and obesity.19107338
ObesityDeregulated Nutrient SensingThe K121Q polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 gene and the rs7566605 genotype located near insulin-induced gene 2 have been shown to be associated with insulin resistance and obesity.19107338
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study was designed to compare the insulin sensitizing effects of thiazolidinediones (TZDs) on the degree of insulin resistance, determined by a short insulin tolerance test (Kitt) in type 2 diabetic patients.19108012
ACSM3 geneDeregulated Nutrient SensingHomozygosity for SAH haplotype 3 was associated with increased adiposity, insulin resistance, and elevated levels of non-HDL-C in the post menopausal women.19108963
One Vessel Coronary Disease, DyslipidemiasDeregulated Nutrient SensingMore men had multivessel disease (78.8 vs. 62.5%, p<0,001), dyslipidaemia (73.2 versus 65.4%, p<0.05), smoking habit (74.3 versus 34.5%, p<0.001) or prior revascularisation (49.7 versus 36.1%, p<0.05).19110808
Osage languageDeregulated Nutrient SensingOSA is associated with increased insulin resistance, but studies of continuous positive airway pressure (CPAP) have shown inconsistent effects on glycemic control.19110882
Beta-Cell Function Measurement, IFNG wt Allele, Diabetes MellitusDeregulated Nutrient SensingFailure of beta-cell function might be the main reason for both IGT and IFG developing into diabetes instead of aggravated insulin resistance.19116942
Pentalogy of Cantrell, AtherosclerosisDeregulated Nutrient SensingAdiponectin attenuated the relationship between VAT and TAS, suggesting that adiponectin and insulin resistance is an important link between visceral adiposity and atherosclerosis.19118830
Hypertensive (finding), glucose metabolismDeregulated Nutrient SensingIn hypertensive patients with IGT telmisartan compared to losartan improved endothelial function and insulin resistance independently, supporting the hypothesis that glucometabolic and vascular insulin resistance are differentially regulated.19118910
DyslipidemiasDeregulated Nutrient SensingThe women had a high rate of dyslipidemia (33%) and engaged in an average of 9187 steps/day (SD 3671).19121220
Metabolic Diseases, square decimeter, ObesityDeregulated Nutrient SensingObesity, insulin resistance and lipid metabolism disorder are the chief risk factors in DM2 patients complicated with FL and phlegm-dampness is the chief pathogenesis.19123321
Increased insulin level, Colorectal Carcinoma, ObesityDeregulated Nutrient SensingObesity, particularly visceral adiposity, is an established risk factor for colorectal cancer (CRC) and this is thought to result, at least in part, from insulin resistance and chronic hyperinsulinemia that may be mediated by adipokines.19123482
Increased insulin level, ObesityDeregulated Nutrient SensingSerum levels of adiponectin, the most abundant protein secreted from adipocytes, are decreased in obesity and are inversely associated with insulin resistance and hyperinsulinemia.19123482
AtherosclerosisDeregulated Nutrient SensingAdipokines are associated with increased adiposity, insulin resistance, and atherosclerosis.19126626
HypothyroidismDeregulated Nutrient SensingThese results may have significant clinical implications because of the high prevalence of both hypothyroidism and insulin resistance in the aging population.19127201
Sleep Apnea, CTCAEDeregulated Nutrient SensingEffects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea.19127383
AcromegalyDeregulated Nutrient SensingAfter adjusting for body mass index (BMI), acromegalic patients presented a more atherogenic lipoprotein profile, consisting of higher levels of triglycerides and apolipoprotein B and alterations in the ratios which estimate insulin resistance and atherogenic risk.19128365
Diabetes MellitusDeregulated Nutrient SensingDespite the marked decrease in progression to diabetes and the improvement in insulin resistance and other cardiovascular risk markers in the ILS and metformin groups, there was no improvement in ACR, on average, in those two groups.19131464
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingMoreover, Cav-1 is involved in SMC differentiation and dyslipidemia confirming the importance of lipid homeostasis in the atherosclerotic phenotype.19134193
Inflammation, Coronary Artery DiseaseDeregulated Nutrient SensingSynergistic role of inflammation and insulin resistance as coronary artery disease risk factors in African Americans and Caucasians.19135196
Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThe separate roles of inflammation and insulin resistance (IR) in the pathogenesis of cardiovascular disease (CVD) are well recognized.19135196
Dyslipidemias, ObesityDeregulated Nutrient SensingBased on questionnaire application, the following data were collected: family structure, socioeconomic level, obesity presence and dyslipidemia in close family relatives, breast feeding, birth weight, child's gestation conditions, feeding habits and the lifestyles of both children and parents.19137988
DyslipidemiasDeregulated Nutrient SensingThis reduction was obtained without any apparent unfavourable side effects such as increased insulin secretion, impaired glucose tolerance or dyslipidaemia.19140039
Left Ventricular Hypertrophy, Dyslipidemias, Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingThe risk of abnormal LVMI values in echocardiogram increased in age over 65 (OR 3.64), in the presence of atherogenic dyslipidaemia (OR 1.73), diabetes (OR 1.68), clinical signs of atherosclerosis (OR 4.36), eGFR < 60 ml/min/1.73 m2 (OR 1.90) and ECG LVH (OR 1.53).19145927
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingInsulin resistance and carotid atherosclerosis in patients with type 2 diabetes.19147142
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance may provide a crucial link between type 2 diabetes and cardiovascular disease.19147142
Increased insulin level, AtherosclerosisDeregulated Nutrient SensingHowever, it is still unclear whether insulin resistance itself or hyperinsulinemia is independently associated with subclinical atherosclerosis.19147142
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Carotid AtherosclerosisDeregulated Nutrient SensingWe hypothesized that insulin resistance, but not hyperinsulinemia, would be associated with carotid atherosclerosis in patients with type 2 diabetes.19147142
Carotid Atherosclerosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFurthermore, odds ratio for carotid atherosclerosis was 1.43 (95% CI: 1.10, 1.86) in type 2 diabetic patients with insulin resistance (lowest quartile of insulin sensitivity) adjusting for known risk factors.19147142
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Carotid AtherosclerosisDeregulated Nutrient SensingInsulin resistance measured by short insulin tolerance test, but not hyperinsulinemia, is independently associated with carotid atherosclerosis in patients with type 2 diabetes.19147142
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHowever, damage was correlated with a marked narrowing of the supplying arterioles as a consequence of hemodynamic and/or metabolic alterations (dyslipidemia, diabetes).19148350
Discordance, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe discordance between the percentages of elevated LDL-c and Total cholesterol (T-c) signifies the role of the LDL-c/non-HDL-c as the main surrogate for dyslipidaemia as a risk for atherosclerosis, and as a primary target of therapy.19149212
Acute Coronary Syndrome, Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingDyslipidemia is common in patients with acute coronary syndromes (ACS) but the mechanism remains unclear.19150068
Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingBoth dyslipidemia and hypertension are important risk factors for cardiovascular disease.19150527
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingStudies have found that there is a higher risk of dyslipidemia among hypertensive patients.19150527
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThis study was designed to investigate the epidemiologic features of some forms of dyslipidemia in rural hypertensive adults in China.19150527
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingThe prevalence of normotriglyceridemic hypoalphalipoproteinemia and severe dyslipidemia was 2.0% and 3.3%, respectively.19150527
Hypertriglyceridemia, Dyslipidemias, diabeticDeregulated Nutrient SensingThe prevalence of isolated hypertriglyceridemia, mixed dyslipidemias, and severe dyslipidemia was higher in diabetic patients compared with nondiabetic patients, in either men or women.19150527
Hypertriglyceridemia, Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingCompared with those of normal weight, obese men had a higher prevalence of mixed dyslipidemias and hypertriglyceridemia/hypoalphalipoproteinemia, whereas isolated hypertriglyceridemia was prevalent in both genders.19150527
Demographics Domain, Obesity, Diabetes MellitusDeregulated Nutrient SensingBaseline higher heart rate (heart rate >or=80 bpm in 1979) predicted the development of obesity, diabetes mellitus (DM), and insulin resistance in 1999 after adjustments for age, sex, and other confounders.19151693
Primary malignant neoplasmDeregulated Nutrient SensingBesides of DM, insulin resistance and high insulin levels are linked as well with increased cancer risk, including PC.19152242
Hepatitis C, Hepatitis Virus-Related Hepatocellular CarcinomaDeregulated Nutrient SensingClinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis: differences and similarities.19152451
Carcinogenic Chlorinated Hydrocarbon, Complete atrioventricular block, Hepatitis C, Chronic, Diabetes MellitusDeregulated Nutrient SensingTo investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C (CHC) or chronic hepatitis B (CHB).19152451
Hepatitis CDeregulated Nutrient SensingThese data may indicate that hepatitis C virus infection is a risk factor for insulin resistance.19152451
Weight Gain, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe results of this study support the conclusion of the Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes that certain SGAs are associated with a higher risk for weight gain, insulin resistance and dyslipidemia.19153944
Cardiovascular DiseasesDeregulated Nutrient SensingThe observed changes may predispose to insulin resistance and significantly increase the risk of developing cardiovascular disease in later life.19154768
Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disordersDeregulated Nutrient SensingWe tested the hypothesis that elevated HGF is associated with insulin resistance and cardiovascular autonomic dysfunction in patients with type 2 diabetes mellitus not receiving insulin treatment.19154948
Depressed mood, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results demonstrate that high levels of HGF are associated with depressed cardiovascular autonomic function and insulin resistance in patients with type 2 diabetes mellitus.19154948
Hyperlipidemia, Obesity, AtherosclerosisDeregulated Nutrient SensingCombined hyperlipidemia in relation to race/ethnicity, obesity, and insulin resistance in the Multi-Ethnic Study of Atherosclerosis.19154954
Hyperlipidemia, ObesityDeregulated Nutrient SensingWe have asked whether the prevalence of combined hyperlipidemia (CHL) differs by race/ethnicity, obesity, and insulin resistance in a contemporary, multiethnic, US cohort.19154954
Cardiovascular Diseases, Obesity, Diabetes MellitusDeregulated Nutrient SensingWe determined the prevalence and adjusted odds of CHL in a cohort of 5923 men and women free of clinically recognized cardiovascular disease and diabetes according to race/ethnicity (white, Chinese, African American, and Hispanic), obesity, and insulin resistance.19154954
Communicable Diseases, Hepatitis C, Diabetes MellitusDeregulated Nutrient SensingSerum retinol-binding protein 4 is inversely correlated with disease severity of chronic hepatitis C. Hepatitis C virus (HCV) infection carries a significant risk for development of insulin resistance (IR) and/or diabetes mellitus.19155083
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWomen, especially having hypertension and dyslipidemia may be potential candidates for further risk stratification by MSCT coronary angiography.19155656
Increased insulin level, Kidney DiseasesDeregulated Nutrient SensingInsulin-resistance hyperinsulinemia is a novel risk factor for renal disease in the general population.19155984
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRecently, soluble CD36 (sCD36) levels were reported to be elevated in type 2 diabetes, and to be tightly correlated with insulin resistance.19156623
Arterial StiffnessDeregulated Nutrient SensingIncreased HDL levels and the presence of insulin resistance syndrome in high risk asymptomatic subjects are predictive for arterial stiffness.19157269
Glucose Intolerance (disease), Impaired cognition, Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance and diabetes as risk factors for cognitive impairment in people at high cardiovascular risk: results from the ONTARGET/TRANSCEND research programme.19157618
DyslipidemiasDeregulated Nutrient SensingThese results support the hypothesis that the longer alleles of the CAG and GGN polymorphisms in the exon-1 of the AR gene, indicative of lower androgenic signaling, respectively protect women from developing dyslipemia and men from developing insulin resistance.19159685
Cardiovascular DiseasesDeregulated Nutrient SensingDespite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease.19159917
Diabetic NephropathyDeregulated Nutrient SensingAdiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan.19164322
Diabetic NephropathyDeregulated Nutrient SensingOur results demonstrate that serum adiponectin levels in type 2 diabetic nephropathy are strongly positively associated with fasting insulin levels and insulin resistance.19164322
Ischemic strokeDeregulated Nutrient SensingPrevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients.19164796
Dyslipidemias, Coronary Artery Disease, Chronic disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity as well as its associated chronic diseases and adverse health consequences such as type 2 diabetes mellitus, dyslipidemia, hypertension, and coronary artery disease are afflicting middle-aged adults and an ever greater number of children globally.19165168
Dyslipidemias, Lupus Erythematosus, Lupus Erythematosus, Systemic, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease.19165647
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingLipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia.19166443
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.19167483
Diabetes MellitusDeregulated Nutrient SensingWe studied the association of SIRT1 genetic variation with mortality in subjects with increased oxidative stress (type 2 diabetes and smokers) in relation to dietary niacin.19167483
Diabetes MellitusDeregulated Nutrient SensingIn subjects with prevalent type 2 diabetes, homozygous carriers of the most common SIRT1 haplotype, 1, had 1.5 times (95%CI 1.1-2.1) increased mortality risk compared to noncarriers.19167483
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe conclude that in subjects with type 2 diabetes, SIRT1 genetic variation influences survival in interaction with dietary niacin and smoking.19167483
Diabetes MellitusDeregulated Nutrient SensingCorrection of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes.19167483
Diabetes Mellitus, Non-Insulin-Dependent, Periodontal DiseasesDeregulated Nutrient SensingThus, the results suggested that periodontal treatment with topical antibiotics improves HbA1c through reduction of CRP, which may relate to amelioration of insulin resistance, in type 2 diabetic patients with periodontal disease.19168253
LipodystrophyDeregulated Nutrient SensingAs the patient presented with pubertal-onset of generalized lipodystrophy and insulin resistance, molecular analysis of the LMNA gene was performed.19169477
Hyperinsulinemic hypoglycemiaDeregulated Nutrient SensingMore pedigrees and long-term follow-up data are needed to document the evolution of beta-cell function and clarify the role of R1174 on insulin resistance and hyperinsulinaemic hypoglycaemia.19170714
Structure of quadriceps femoris muscleDeregulated Nutrient SensingInsulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged >or=70 years.19171728
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was defined according to the two criteria: high triglyceride and/or low high density lipoprotein cholesterol (TG > or = 150 mg and/or HDL-C < 40 mg/dl), and high total cholesterol (TC > or = 220 mg/dl).19176866
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingMaintaining good oral hygiene by regular teeth brushing may prevent type 2 diabetes, hypertension and dyslipidemia.19176866
ObesityDeregulated Nutrient SensingVisfatin is a new cytokine that act as an insulin analogue on the insulin receptor and may link obesity and insulin resistance.19178507
Thyroid dysfunction, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia is a well-known manifestation of thyroid dysfunction.19178521
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrevalence, awareness, and management of hypertension, dyslipidemia, and diabetes among United States adults aged 65 and older.19181717
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingAdults aged 65 and older are disproportionately affected by hypertension, dyslipidemia, and diabetes, which are established risk factors for cardiovascular disease (CVD).19181717
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingGoal attainment among those treated is problematic for all three conditions-hypertension (48.8%), dyslipidemia (64.9%), and diabetes (50.4%).19181717
Hypertension, CTCAEDeregulated Nutrient SensingThese measures may decrease insulin resistance, improve glycemic control, lipid abnormalities, and hypertension.19183462
Hepatitis C, ChronicDeregulated Nutrient SensingInsulin resistance is a candidate predictive factor for virological response to peginterferon plus ribavirin (PEG/RBV) therapy in chronic hepatitis C patients.19184426
Myocardial IschemiaDeregulated Nutrient SensingInsulin resistance seems to be a link between esRAGE and visfatin in IHD diabetics.19184512
Dyslipidemias, Aortic Stiffness, Diabetes MellitusDeregulated Nutrient SensingOther variables associated with increased aortic stiffness were older age, heart rate, diabetes duration, 24h pulse pressure, dyslipidemia and physical inactivity.19185301
Weight Gain, Hypertension, CTCAE, Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingThere is suggestive evidence that chronic elevations of parathyroid hormone (PTH), associated with poor vitamin D status or low calcium intake, can increase risk for insulin resistance, weight gain, hypertension, and left ventricular hypertrophy, while stimulating production of acute phase reactants.19188028
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive diseaseDeregulated Nutrient SensingIn multivariate analysis, HBP prevalence was associated with older age, male sex, low educational level, high alcohol intake, awareness of diabetes or dyslipidaemia, obesity and parental history of myocardial infarction.19188810
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive diseaseDeregulated Nutrient SensingHBP awareness was associated with older age, female sex, awareness of diabetes or dyslipidaemia, obesity and parental history of myocardial infarction.19188810
ACACA wt AlleleDeregulated Nutrient SensingAt 3-h AMPK activity and AMPK, ACC and AS160 phosphorylation were unchanged, but ERK1/2 phosphorylation increased at both AICAR doses.19190259
Cell DeathDeregulated Nutrient SensingWe hypothesised that increased insulin demand as a result of obesity/insulin resistance causes ER stress in pancreatic beta cells, thereby promoting beta cell death.19190890
TG gene, DyslipidemiasDeregulated Nutrient SensingIn patients with mixed dyslipidemia characterized by increased triglycerides (TG), decreased high-density lipoprotein (HDL) cholesterol, and increased low-density lipoprotein (LDL) cholesterol, monotherapy with lipid-altering drugs often fails to achieve all lipid targets.19195513
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum retinal-binding protein 4 is positively related to insulin resistance in Chinese subjects with type 2 diabetes.19195734
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingPrediction of type 2 diabetes using alternate anthropometric measures in a multi-ethnic cohort: the insulin resistance atherosclerosis study.19196891
Diabetes MellitusDeregulated Nutrient SensingIn contrast, measures of insulin resistance and adiponectin were not associated with weight change in this cohort of older persons without diabetes.19197256
Glucose Intolerance (disease), Hepatitis BDeregulated Nutrient SensingPrevalence of glucose intolerance in patients with chronic hepatitis B or C: a prospective case-control study.19200136
Communicable Diseases, Glucose Intolerance (disease), Complete atrioventricular block, Carcinogenic Chlorinated Hydrocarbon, Hepatitis B, ChronicDeregulated Nutrient SensingDespite several studies, the association of glucose intolerance with chronic hepatitis B (CHB) or C (CHC) virus infection remains controversial.19200136
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingOGTT was performed in all cases, except in known diabetics, and glucose intolerance was defined as impaired glucose tolerance (IGT), OGTT-diabetes or known diabetes.19200136
Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular block, Diabetes MellitusDeregulated Nutrient SensingCompared with their own controls, CHB patients had a higher prevalence of IGT (13.6% vs 2.5%, P = 0.018) and family history of diabetes (34.6% vs 16.0%, P = 0.011), while CHC patents had higher prevalence of glucose intolerance (37.0% vs 15.7%, Rho = 0.001), mostly because of more frequent IGT (21.3% vs 6.5%, Rho = 0.003).19200136
Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular blockDeregulated Nutrient SensingAfter age and BMI adjustment, patients with CHC compared with those with CHB had significantly higher prevalence of glucose intolerance (37.0% vs 29.6%, P = 0.037).19200136
Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular blockDeregulated Nutrient SensingIn conclusion, increased prevalence of glucose intolerance is documented by OGTT both in CHC and CHB patients compared with age, sex and BMI matched controls.19200136
Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular blockDeregulated Nutrient SensingGlucose intolerance is more frequent in CHC than CHB patients, regardless of known risk factors.19200136
Gastrointestinal symptom, Liver CirrhosisDeregulated Nutrient SensingLiver cirrhosis is associated with increased prevalence of gastrointestinal symptoms, insulin resistance, and altered gut transit.19200458
Dyslipidemias, S-AdenosylhomocysteineDeregulated Nutrient SensingAn association between obstructive sleep apnoea/hypopnea (OSAH) and cardiovascular risk factors such as dyslipidemia has been described in adults and high-risk populations.19200781
Inflammation, Dyslipidemias, Carotid Intima-Media ThicknessDeregulated Nutrient SensingEchogenecity of the carotid intima-media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.19200993
glucose metabolismDeregulated Nutrient SensingAll patients were divided into groups according to glucometabolic and coronary status and insulin resistance.19202950
Coronary heart diseaseDeregulated Nutrient SensingThere was no correlation between glycemic status and insulin resistance, and severity of coronary heart disease.19202950
Inflammation, Hepatitis C, AtherosclerosisDeregulated Nutrient SensingHepatitis C virus infection in hemodialysis patients is not associated with insulin resistance, inflammation and atherosclerosis.19203507
Hepatitis C, Endothelial dysfunction, AtherosclerosisDeregulated Nutrient SensingIn attempt to address this issue in chronic hemodialysis (HD) patients, we evaluated the relation of HCV infection with inflammatory markers, endothelial dysfunction, insulin resistance and atherosclerosis.19203507
Communicable Diseases, AtherosclerosisDeregulated Nutrient SensingHCV infection was not related to atherosclerosis and insulin resistance in hemodialysis patients.19203507
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingCompared to normotensive subjects, those with high blood pressure showed a significantly higher prevalence of obesity, overweight, and dyslipidemia.19205546
Coronary heart diseaseDeregulated Nutrient SensingThe findings suggest that insulin and insulin resistance exacerbate the adverse effect of PM(10) on cardiac autonomic control and thus risk of coronary heart disease among nondiabetic, postmenopausal women with impaired fasting glucose.19208727
Dyslipidemias, Cardiovascular Diseases, Cardiovascular systemDeregulated Nutrient SensingAlthough statins are widely used for the prevention and management of cardiovascular disease in patients with dyslipidemia, the prevalence of cardiovascular comorbidities among statin users has not been well studied.19210153
Heart Diseases, Atrial Fibrillation by ECG Finding, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThey were also more likely to have a past medical history of atrial fibrillation or hypertension, and less likely to have a history of heart disease, dyslipidemia, or smoking.19211482
Increased insulin level, HyperglycemiaDeregulated Nutrient SensingJZM can not reverse the forming processes of hyperglycemia, hyperinsulinemia, and insulin resistance in MSG rats.19213346
Hyperglycemia, Dyslipidemias, Non-alcoholic Fatty Liver Disease, No metabolic abnormalities, Weight decreasedDeregulated Nutrient SensingEven a small weight reduction was associated with improvements in NAFLD and related metabolic abnormalities such as dyslipidemia and hyperglycemia.19214024
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe percentage of patients with diabetes, dyslipidemia, hypertension and left main disease increased over time (P<0.05).19214298
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingParental history of type 2 diabetes mellitus increases risk of not only glucose intolerance but also other cardiometabolic risk factors like overweight, low high-density lipoprotein cholesterol, and high blood pressure in Asian Indian adolescents.19217449
Microalbuminuria, Endothelial dysfunction, Metabolic Syndrome XDeregulated Nutrient SensingMicroalbuminuria (MA) clusters with the metabolic syndrome and insulin resistance and may reflect endothelial dysfunction.19217459
ObesityDeregulated Nutrient SensingUsual relation between caloric intake and blood pressure in obese may be due to insulin resistance induced by obesity.19218718
Fatty LiverDeregulated Nutrient SensingIn addition, the higher ALT, Homeostasis model assessment- insulin resistance (HOMA-IR), cholesterol, triglyceride, and non-HDL levels and lower HDL-C as the severity of fatty liver increased.19221666
Inflammation, atheroscleroticDeregulated Nutrient SensingThe inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques.19223085
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe value of diagnostic categories of glucose intolerance for predicting type 2 diabetes is much debated.19224196
Glucose Intolerance (disease), AcromegalyDeregulated Nutrient SensingInsulin resistance, leading to glucose intolerance is one of the most important contributory factors to the cardiovascular mortality in acromegaly.19224501
Increased insulin level, AcromegalyDeregulated Nutrient SensingIn patients with acromegaly insulin resistance and hyperinsulinemia are positively correlated with the level of activity of the disease.19224501
Refractory anemias, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFurther studies are needed to elucidate molecular mechanisms of dyslipidemia in RA and to ensure the choice of optimal targets for therapeutic modalities reducing the risk of cardiovascular disorders.19227308
Dyslipidemias, ObesityDeregulated Nutrient SensingAssociation of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients.19228823
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingFetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease.19228823
Dyslipidemias, ObesityDeregulated Nutrient SensingTruncal obesity is linked to dyslipidemia and also predicts CV mortality.19228823
Dyslipidemias, ObesityDeregulated Nutrient SensingThis study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients.19228823
Inflammation, Malnutrition, Dyslipidemias, ObesityDeregulated Nutrient SensingFetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation.19228823
TG gene, HD Term Type, DyslipidemiasDeregulated Nutrient SensingIt may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients.19228823
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingOur results suggest that obesity and insulin resistance that accompanies obesity may influence platelet reactivity in patients with type 2 diabetes.19228864
Inflammation, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingUremic dyslipidemia and inflammation take part in the etiology of atherosclerosis.19229822
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was a very high prevalence of diabetes, hypertension and dyslipidemia in the patients.19230422
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes.19230737
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBetaglucan enriched bread may contribute to the improvement of the lipid profile and insulin resistance in patients with T2D.19230737
Sleep Apnea, ObstructiveDeregulated Nutrient SensingMarkers of glycemic control and insulin resistance in non-diabetic patients with Obstructive Sleep Apnea Hypopnea Syndrome: does adherence to CPAP treatment improve glycemic control?19231280
Neurodegenerative Disorders, Primary malignant neoplasm, Acne, Atherosclerosis, Diabetes Mellitus, ObesityDeregulated Nutrient SensingInsulin/IGF-1 signalling is involved in the regulation of fetal growth, T-cell maturation in the thymus, linear growth, pathogenesis of acne, atherosclerosis, diabetes mellitus, obesity, cancer and neurodegenerative diseases, thus affecting most chronic diseases of Western societies.19232475
Metabolic Diseases, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAfter the first OGTT, 66 patients (75%) were found to have carbohydrate metabolism disorders (41% glucose intolerance and 34% diabetes mellitus).19232754
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAfter the second OGTT 39 patients (44.3%) had carbohydrate metabolism disorders (26% glucose intolerance and 18% diabetes mellitus).19232754
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes or insulin resistance, overweight, arterial hypertension, and dyslipidaemia are recognized risk factors for cardiovascular (CV) disease.19237305
ObesityDeregulated Nutrient SensingRelative importance and conjoint effects of obesity and physical inactivity for the development of insulin resistance.19237994
ObesityDeregulated Nutrient SensingObesity and physical inactivity are related to the development of insulin resistance, but their relative importance and conjoint effects are unclear.19237994
ObesityDeregulated Nutrient SensingOur results imply that obesity and physical inactivity may increase insulin resistance and metabolic risk by partly independent pathways, and emphasize the importance of strategies that address both obesity and physical inactivity to achieve increased public health.19237994
Bone Diseases, Metabolic acidosis, Anemia, DyslipidemiasDeregulated Nutrient SensingHypertension/proteinuria was managed appropriately in 72.4% of cases, anaemia in 56.2%, bone disease in 16.7%, metabolic acidosis in 60.2% and dyslipidemia in 61.4%.19239592
Dyslipidemias, diabeticDeregulated Nutrient SensingEnrollment in PCAP was a predictor in reaching diabetic and some dyslipidemia therapeutic goals.19240259
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe GCKR rs780094 and GCK rs1799884 polymorphisms have been reported to be associated with dyslipidaemia and type 2 diabetes in white Europeans.19241058
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingConsistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals.19241058
Spinal Cord InjuriesDeregulated Nutrient SensingAssociation of C-reactive protein and insulin resistance in patients with chronic spinal cord injury.19242618
Spinal Cord InjuriesDeregulated Nutrient SensingTo study the association between C-reactive protein levels and insulin resistance in patients with spinal cord injury.19242618
Spinal Cord InjuriesDeregulated Nutrient SensingMost young and middle-aged patients with chronic spinal cord injury with high C-reactive protein levels also have high insulin resistance, and their C-reactive protein levels have well correlated with insulin resistance.19242618
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia and high blood pressure are both major cardiovascular disease risk factors.19243712
Weight Gain, Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingSeveral second-generation antipsychotic (SGA) drugs have been associated with weight gain, hyperglycemia, and dyslipidemia.19244091
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMore effort is needed to improve diabetes and dyslipidemia screening in these at-risk patients.19244091
Critical Illness, Beta-cell dysfunctionDeregulated Nutrient SensingOur finding that beta-cell dysfunction is present in a subset of critically ill children with CIH challenges the assertion from adult studies that CIH is primarily the result of elevated insulin resistance.19245691
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe most frequent risk factors were dyslipidemia (60%), smoking (44%), and hypertension (39%).19246709
Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingUrban Indians have a high prevalence of insulin resistance, hypertension and cardiovascular disease.19246794
Hypertensive (finding), Glucose Intolerance (disease), PrehypertensionDeregulated Nutrient SensingSubjects with pre-hypertension had body mass index, waist-hip ratio and frequency of glucose intolerance, which was intermediate between normotensive and hypertensive subjects.19246794
Diabetes MellitusDeregulated Nutrient SensingDiabetes related to mutations of the lamin A/C gene is difficult to treat because of severe insulin resistance.19249234
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingWe randomized 16 diabetologists and 98 patients with type 2 diabetes referred to a subspecialty diabetes clinic to use the Statin Choice decision aid or a patient pamphlet about dyslipidaemia, and then to receive these materials from either the clinician during the visit or a researcher prior to the visit.19250151
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingOverweight was observed in 49.3 % of adults, while 30.9 % were hypertensive and 44.1 % had dyslipidaemia.19250574
DyslipidemiasDeregulated Nutrient SensingFibrates are useful in managing dyslipidaemia; reports highlight an expected increase in HDL-C of 10-15% in conjunction with falls in plasma triglycerides of approximately 30%.19251953
Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingIn adults, it is linked to cardiovascular disease, insulin resistance, and hypertension.19255005
Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Hepatitis, Chronic, SteatohepatitisDeregulated Nutrient SensingAssociation of insulin resistance with hepatic steatosis and progression of fibrosis in Chinese patients with chronic hepatitis C. To investigate the relationships between insulin resistance, hepatic steatosis, and fibrosis in consecutive non-diabetic Chinese CHC patients with biopsy results.19260496
Carcinogenic Chlorinated Hydrocarbon, Communicable Diseases, Fibrosis Assessment, SteatohepatitisDeregulated Nutrient SensingIn Chinese CHC patients, insulin resistance can occur in earlier stage of infection and closely related with hepatic steatosis and fibrosis.19260496
Diabetes MellitusDeregulated Nutrient SensingLifestyle interventions during the phase of insulin resistance mitigate cardiovascular risk and prevent diabetes.19261690
Obesity, Visceral, Diabetes MellitusDeregulated Nutrient SensingWe investigated the associations of gamma-glutamyltransferase (GGT) with visceral obesity, adiponectin and retinol binding protein 4 (RBP4), and insulin resistance (IR) and compared these associations with other liver enzymes in non-diabetes.19264371
HypoxiaDeregulated Nutrient SensingDownregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.19265035
Weight Gain, DyslipidemiasDeregulated Nutrient SensingThere is increasing concern that some atypical antipsychotic therapies are associated with adverse metabolic symptoms, such as weight gain, dyslipidaemia and glucose dysregulation.19267255
diabeticDeregulated Nutrient SensingInsulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects.19267279
diabeticDeregulated Nutrient SensingTo determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects.19267279
DyslipidemiasDeregulated Nutrient SensingThis is the first study to increase the adherence to multiple interventions in patients with dyslipidemia, and other CVD risk factors, in both primary care and teaching hospital settings.19268376
Weight Gain, DyslipidemiasDeregulated Nutrient SensingWeight gain was significantly greater in OLZ-treated patients, as was accentuation of dyslipidemia.19268968
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe patients with LMCA disease were more likely to be male, older, and have diabetes mellitus or dyslipidemia, whereas cigarette smoking was found as an independent predictor of isolated LMCA.19274028
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpaired oxidative capacity of skeletal muscle mitochondria contribute to insulin resistance and type 2 diabetes (T2D).19274082
Migraine DisordersDeregulated Nutrient SensingRecent studies suggest that insulin resistance is more common in patients with migraine.19276782
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia frequencies showed no difference between 2 groups.19276782
Renal Insufficiency, Inflammation, DyslipidemiasDeregulated Nutrient SensingIt specifically addressed the hypotheses that renal dysfunction in these patients may associate with the presence of insulin resistance, dyslipidaemia, uric acid levels and/or current levels of systemic inflammation.19279016
Renal Insufficiency, Dyslipidemias, Extra-articular, Refractory anemiasDeregulated Nutrient SensingRenal dysfunction in RA is quite common and associates with classic cardiovascular risk factors such as advanced age and dyslipidaemia, levels of SUA and the presence of extra-articular disease.19279016
Dyslipidemias, Coronary Arteriosclerosis, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe prevalence rates of ischaemic heart disease, dyslipidaemia, arterial hypertension and diabetes suggest that Joinville presents a mixed pattern of cardiovascular risk, a pattern seen in developed and developing countries alike.19279029
Arterial Stiffness, Inflammation, Endothelial dysfunction, ETV3 wt AlleleDeregulated Nutrient SensingHow MetS increases CVD risk is incompletely understood, but increasing arterial stiffness is one candidate link, which in turn could be explained by (low-grade) inflammation, endothelial dysfunction (ED) or insulin resistance (IR).19279658
Glaucoma, Open-Angle, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDue to the patient age, cholesterol values, as common factors in primary open-angle glaucoma and atherosclerosis genesis, could be concern in the same aetiology based on dyslipidaemia as well.19284402
Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingRheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study.19284557
DiseaseDeregulated Nutrient SensingAlthough recent evidence suggests a link between SIRT1 activity and metabolic homeostasis during CR, its pathological role in human disease is not yet fully understood.19286634
physiopathological, Diabetes MellitusDeregulated Nutrient SensingLikewise, activation of Sirt1 prevents the hyperglycemia-induced vascular cell senescence and thereby protects against vascular dysfunction in mice with diabetes.19286634
Hyperglycemia, Disorder of eye due to diabetes mellitusDeregulated Nutrient SensingThese findings represent a novel mechanism of vascular cell senescence induced by hyperglycemia and suggest a protective role of SIRT1 in the pathogenesis of diabetic vasculopathy.19286634
Fibrosis Assessment, Fatty degeneration, Hepatitis CDeregulated Nutrient SensingInfluence of insulin resistance on hepatic fibrosis and steatosis in hepatitis C virus (HCV) mono-infected compared with HIV-HCV co-infected patients.19292832
Steatohepatitis, Fibrosis AssessmentDeregulated Nutrient SensingTo test the association among insulin resistance (IR), liver fibrosis and liver steatosis in HIV-HCV and HCV-infected patients.19292832
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingInsulin resistance was independently associated in HCV patients with fibrosis [odds ratio (OR) = 2.04 (95% CI 1.02-4)], a body mass index (BMI) >25 kg/m(2) [OR = 3.33 (1.47-7.69)] and steatosis [OR = 3.33 (1.67-6.67)].19292832
Fibrosis, Liver, Fatty degenerationDeregulated Nutrient SensingInsulin resistance is associated with liver fibrosis and steatosis in HCV mono-infected, but not in HIV-HCV co-infected patients.19292832
Weight decreased, Diabetes MellitusDeregulated Nutrient SensingAfter insulin withdrawal, the patient's condition markedly improved: he showed better diabetes control, decrease in insulin resistance, weight loss, reduced BMI, reduced waist circumference, sagittal abdominal diameter and body fat, increased fitness level, normalized blood pressure and decreased heart rate at rest.19300386
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingThe prevalence of selected CVRF was: hypertension: 74.5%; dyslipidemia: 77.7%; smoking: 14.9%; obesity 44.9%, and familial CVD: 38.4%.19302689
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe impact of dyslipidaemia on cardiovascular mortality in individuals without a prior history of diabetes in the DECODE Study.19303072
Obesity, Visceral, Beta-cell dysfunctionDeregulated Nutrient SensingWe studied whether genetic variation within these genes contributes to the development of disproportionate visceral obesity and obesity-related traits, such as insulin resistance and beta-cell dysfunction.19303973
ObesityDeregulated Nutrient SensingAngiopoietin-related growth factor (AGF) was recently introduced as a novel liver-derived protein that antagonizes obesity and insulin resistance.19303977
diabeticDeregulated Nutrient SensingThis preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with VFA and insulin resistance in type 2 diabetic patients not receiving insulin treatment.19320939
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results of this preliminary study indicate that the presence of WML was associated with the high VFA and insulin resistance in Japanese patients with type 2 diabetes mellitus.19320939
Demographics Domain, Dyslipidemias, Diabetes Mellitus, Haiti, Hypertension, CTCAEDeregulated Nutrient SensingHypertension (HT), diabetes mellitus (DM) and dyslipidemia (LIP) were defined in accordance with guidelines.19321325
Beta-cell dysfunctionDeregulated Nutrient SensingThe same allele associates with estimates of beta-cell dysfunction and hepatic insulin resistance.19324940
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingGender-associated differences in the lipid profile are evident in subjects presenting with dyslipidemia and might be of potential relevance for diagnostics and therapy for the prevention of atherosclerosis.19327602
Glucose Intolerance (disease), OverweightDeregulated Nutrient SensingOverweight or central obesity is generally associated with increases in fasting insulin levels, insulin resistance, and glucose intolerance and has been identified as a target for new therapeutic strategies, including early change in lifestyle.19327605
Metabolic Diseases, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingResults suggest that increased serum uric acid concentration is associated with an increased prevalence of metabolic disorders such as obesity, dyslipidemia and hypertension in the Hangzhou population.19329400
Renal Insufficiency, Hypertension, CTCAEDeregulated Nutrient SensingEssential hypertension is a clinical condition associated with insulin resistance and progressive impairment of renal function that increases cardiovascular events.19330922
Hypertensive (finding)Deregulated Nutrient SensingWe demonstrate a significant relationship between IGF-1 and GFR in a large sample of never treated hypertensive patients, probably as consequence of insulin resistance/hyperinsulinemia, which is a very frequent condition in high BP.19330922
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no association between the anti-CCP antibodies and cardiovascular risk factors such as smoking, hypertension, dyslipidemia, being overweight, or diabetes mellitus.19333979
Pancreatic carcinomaDeregulated Nutrient SensingInsulin resistance has been implicated in the etiology of pancreatic cancer.19336549
Impaired cognitionDeregulated Nutrient SensingTargeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach.19336640
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTwin status per se is associated with abdominal obesity, insulin resistance, and increased prevalence of type 2 diabetes in elderly twins.19336677
Dyslipidemias, omega-3 fatty acids, Endothelial dysfunctionDeregulated Nutrient SensingCombined therapy with omega-3-PUFAs and rosuvastatin improves endothelial function in South Asian subjects with dyslipidemia and endothelial dysfunction.19337557
Chromium deficiency, DyslipidemiasDeregulated Nutrient SensingChromium deficiency is associated with impaired glucose tolerance (IGT) and dyslipidemia.19337698
ObesityDeregulated Nutrient SensingDecreased activity of desaturase 5 in association with obesity and insulin resistance aggravates declining long-chain n-3 fatty acid status in Cree undergoing dietary transition.19338705
ObesityDeregulated Nutrient SensingThe present study indicates that the dietary transition of reduced consumption of fish among younger Cree may compound the effects of obesity and emerging insulin resistance which, in turn, could reduce bioavailability of HUFA n-3 (through reduced Delta5 activity).19338705
Hypertension, CTCAE, Demographics Domain, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no significant correlation of aspirin resistance with traditional risk factors like diabetes mellitus (DM), hypertension or dyslipidemia.19339237
Acute lymphocytic leukemiaDeregulated Nutrient SensingBody mass index predicts insulin resistance in survivors of pediatric acute lymphoblastic leukemia.19340854
Prediabetes syndromeDeregulated Nutrient SensingAt study time, one subject had prediabetes; eight (29.6%) had insulin resistance.19340854
Acute lymphocytic leukemiaDeregulated Nutrient SensingWaist/hip ratio and BMI at ALL diagnosis also correlated with insulin resistance, but these factors' effects could not be separated from BMI at study time.19340854
Hyperglycemia, Glucose Intolerance (disease), Acute lymphocytic leukemiaDeregulated Nutrient SensingVariations in ALL therapy and presence of transient hyperglycemia do not appear to increase risk of glucose intolerance or insulin resistance in the first few years after completion of therapy.19340854
Hypertension, CTCAE, Lower Urinary Tract Symptoms, DyslipidemiasDeregulated Nutrient SensingIncreased odds of LUTS were also observed in men undergoing medical treatment for hypertension or dyslipidemia.19341367
Hypertension, CTCAE, Lower Urinary Tract Symptoms, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOur present findings, together with previous epidemiological and experimental evidence, suggest that LUTS might share common etiological factors with diabetes mellitus, hypertension, and dyslipidemia.19341367
Arthralgia, Dyslipidemias, Gastroesophageal reflux disease, Sleep Apnea, CTCAE, Depression, CTCAE, Back Pain, Hernia, Urinary Stress IncontinenceDeregulated Nutrient SensingThe analysis revealed a significantly greater prevalence and severity of dyslipidemia (P <.05), gastroesophageal reflux disease (P <.05), back pain (P <.0001), joint pain (P <.05), sleep apnea (P <.01), stress incontinence (P <.01), and hernia (P <.05) among patients with depression.19342306
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia remains underdiagnosed and undertreated in patients with coronary artery disease.19344008
FAI - Free androgen index measurement, Blood GlucoseDeregulated Nutrient SensingAndrogenicity, as measured by low sex hormone-binding globulin (SHBG) and elevations in testosterone and free androgen index (FAI), is associated with adverse cardiovascular (CV) outcomes, possibly due to effects on insulin resistance and glycemia.19344226
HyperglycemiaDeregulated Nutrient SensingPostoperative insulin resistance, resulting in hyperglycemia, is strongly associated to morbidity and mortality in surgical patients but the underlying mechanisms are unclear.19346035
InflammationDeregulated Nutrient SensingAs increasing data suggests a link between inflammation and insulin resistance, we aimed to evaluate if the expression of inflammatory and insulin signaling genes is regulated in skeletal muscle during surgery.19346035
InflammationDeregulated Nutrient SensingThe observed gene expression changes in skeletal muscle during surgery occurred mainly in inflammatory pathways, suggesting a possible role for inflammation in the development of postoperative insulin resistance.19346035
Inflammation, ObesityDeregulated Nutrient SensingAn Ask1-MKK4-p38MAPK/JNK pathway reflects adipocyte stress associated with adipose tissue inflammation, linking visceral adiposity to whole-body insulin resistance in obesity.19351724
Hypertension, CTCAEDeregulated Nutrient SensingThe extraskeletal effects of PTH, such as insulin resistance, arterial hypertension, and cardiovascular (CV) risk, may however be reversible by operation.19351725
InflammationDeregulated Nutrient SensingNo significant differences were observed between the groups for blood pressure, markers of insulin resistance, detailed cholesterol metabolism, adipokines, or parameters of inflammation and CV surrogate markers.19351725
DyslipidemiasDeregulated Nutrient SensingLevels of inflammatory markers and their correlation with dyslipidemia in diabetics.19356332
DyslipidemiasDeregulated Nutrient SensingTo measure the levels of inflammatory markers (serum ferritin and high sensitivity C-reactive protein) and dyslipidemia in diabetics and to find a correlation between these inflammatory markers and dyslipidemia.19356332
Inflammation, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLow-grade inflammation exists in Diabetes mellitus and it is positively related with dyslipidemia (except for HDL cholesterol) in diabetics.19356332
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWhen compared with control subjects, the EMT was increased in both the diabetes (p < 0.0001) and dyslipidemia (p = 0.04) groups.19356553
Metabolic Diseases, Demographics Domain, Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and dyslipidemia.19360107
Coronary Arteriosclerosis, Coronary Artery Disease, diabeticDeregulated Nutrient SensingEffects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease.19361872
Traumatic injuryDeregulated Nutrient SensingPreoperative fasting of 2 hours minimizes insulin resistance and organic response to trauma after video-cholecystectomy: a randomized, controlled, clinical trial.19363695
Traumatic injuryDeregulated Nutrient SensingWe investigated the influence of a carbohydrate-rich drink given 2 h before laparoscopic cholecystectomy on insulin resistance and the metabolic response to trauma.19363695
Traumatic injuryDeregulated Nutrient SensingAbbreviation of the period of preoperative fasting and administration of a carbohydrate beverage diminishes insulin resistance and the organic response to trauma.19363695
NeoplasmsDeregulated Nutrient SensingOverall, our experiments identify a c-Myc-SIRT1 feedback loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of SIRT1 in tumor suppression.19364925
dysmetabolic syndrome, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Coronary heart diseaseDeregulated Nutrient SensingThe metabolic syndrome (also known as syndrome X, insulin resistance syndrome, dysmetabolic syndrome, deadly quartet and plurimetabolic syndrome) is a cluster of factors associated with increased risk of developing coronary heart disease and/or type 2 diabetes.19366079
Metabolic Syndrome XDeregulated Nutrient SensingVitamin D deficiency is common in the middle-aged and elderly Chinese population, and a low 25(OH)D level is significantly associated with an increased risk of having metabolic syndrome and insulin resistance.19366976
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingLittle information is available on the relation between insulin resistance and acute myocardial infarction.19367169
ObesityDeregulated Nutrient SensingAdipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults.19368945
ObesityDeregulated Nutrient SensingWe investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children.19368945
long-chain fatty acid bindingDeregulated Nutrient SensingInefficient muscle long-chain fatty acid (LCFA) combustion is associated with insulin resistance, but molecular links between mitochondrial fat catabolism and insulin action remain controversial.19369366
Metabolic DiseasesDeregulated Nutrient SensingIn our population, RBP4 circulating levels were not significantly correlated with obesity-related parameters, although a tendency to correlate with waist circumference suggests a relationship with insulin resistance and other metabolic disorders.19369430
Hypertension, CTCAE, Dyslipidemias, Prediabetes syndromeDeregulated Nutrient SensingThere are increased constellation of other cardiovascular risk factors (hypertension, dyslipidaemia, etc), in prediabetes as compared to normal population.19370946
Inflammation, HypertrophyDeregulated Nutrient SensingResistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction.19372460
Hypertensive (finding), ObesityDeregulated Nutrient SensingThe influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients.19373236
Hypertensive (finding), ObesityDeregulated Nutrient SensingHowever, few echocardiographic studies have assessed the relations of insulin resistance and obesity to LA size in hypertensive patients.19373236
Hypertensive (finding), ObesityDeregulated Nutrient SensingWe enrolled 106 never-treated hypertensive patients (57 men and 49 women) to assess the possible relations of insulin resistance and obesity to LA size.19373236
Dyslipidemias, Lipid Metabolism DisordersDeregulated Nutrient SensingDyslipidemia and the treatment of lipid disorders in African Americans.19375555
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDespite the high prevalence of cardiovascular disease documented among the African-American population, there has been little emphasis on the role of dyslipidemia as a prominent risk factor in this large subpopulation.19375555
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was defined as the presence of either hypercholesterolemia or hypertriglyceridemia using National Cholesterol Education Program III criteria and the fasting lipid measurements, self-reported treatment history, and medication survey available from 5302 Jackson Heart Study participants.19375555
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo assess whether an increased genetic predisposition for type 2 diabetes mellitus (T2DM) influences the contributions of insulin resistance and impaired insulin secretion to impaired glucose tolerance (IGT), 437 subjects not known to have T2DM underwent an oral glucose tolerance test and a 3-hour hyperglycemic clamp.19375581
ObesityDeregulated Nutrient SensingAdjustment for obesity abolished the differences in insulin resistance but not plasma insulin responses.19375581
Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disordersDeregulated Nutrient SensingThis preliminary study was therefore designed to test the hypothesis that WML is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetes mellitus patients without insulin treatment.19375594
Depressed mood, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results suggested that WML was associated with depressed cardiovascular autonomic function and insulin resistance and that HOMA index and the percentage WR of (123)I-MIBG were independent associations for WML in Japanese patients with type 2 diabetes mellitus.19375594
Calcification of coronary arteryDeregulated Nutrient SensingInsulin resistance independently predicts the progression of coronary artery calcification.19376325
SLC25A20 geneDeregulated Nutrient SensingInsulin resistance, in addition to the traditional cardiac risk factors, independently predicts progression of CAC in a community-based population without clinical CAD.19376325
Cerebral atrophy, Diabetes MellitusDeregulated Nutrient SensingTo determine the impact of insulin resistance short of diabetes on the arteriolar-to-venular ratio (AVR) and whether AVR is related to cerebral atrophy.19376581
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThese novel findings indicate that insulin resistance short of diabetes and independent of age and hypertension has a negative impact on retinal vessel health.19376581
Prostate carcinomaDeregulated Nutrient SensingRole of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells.19377286
Dyslipidemias, OverweightDeregulated Nutrient SensingMore than half of these adolescents with nonoptimal blood pressure values had additional cardiovascular risk factors (overweight defined as body mass index >or=90th percentile for sex and age, dyslipidaemia defined as total cholesterol >5.0 mmol/l or high-density lipoprotein cholesterol less than 1.0 mmol/l or smoking).19378395
Hepatitis C, Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingAmino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus.19382270
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOne-third of patients had abnormal glycaemia, hypertension and dyslipidaemia concurrently.19383060
Dyslipidemias, Cardiovascular Diseases, diabeticDeregulated Nutrient SensingForty-seven patients were smokers (6%), 90 (13%) had a personal history of cardiovascular disease, 42 (6%) were diabetic, 255 (37%) had dyslipidemia, and 31 (5%) were both diabetic and dyslipidemic.19388489
No metabolic abnormalities, Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingBoth obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance.19390517
Chronic Kidney DiseasesDeregulated Nutrient SensingPlasma adiponectin levels are difficult to interpret in the setting of CKD because of multiple confounders that may influence the relationship between adiponectin, adiposity, and insulin resistance.19393918
TG gene, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe association between 'metabolic dyslipidemia' as defined by high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels and the risk of coronary heart disease (CHD) risk is not known.19394708
TG gene, DyslipidemiasDeregulated Nutrient SensingMetabolic dyslipidemia was defined by combination of increased triglyceride (TG) levels (>=150 mg/dl) and low high-density lipoprotein cholesterol (HDL-C) levels (<=50 mg/dl for women and <=40 mg/dl for men).19394708
TG gene, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingCompared to men with normal HDL and normal TG, men with metabolic dyslipidemia had an increased risk for CHD (HR 1.61, 95% CI 1.40-1.86).19394708
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAmong women, metabolic dyslipidemia was associated with increased CHD risk (HR 1.78, 95% CI 1.47-2.15).19394708
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMetabolic dyslipidemia is associated with an increased risk of CHD.19394708
SchizophreniaDeregulated Nutrient SensingWe studied the expression of IDE protein in postmortem brains of patients with schizophrenia and controls because: (1) the gene encoding IDE is located on chromosome 10q23-q25, a gene locus linked to schizophrenia; (2) insulin resistance with brain insulin receptor deficits/receptor dysfunction was reported in schizophrenia; (3) the enzyme cleaves IGF-I and IGF-II which are implicated in the pathophysiology of the disease; and (4) brain gamma-endorphin levels, liberated from beta-endorphin exclusively by IDE, have been reported to be altered in schizophrenia.19394958
Dyslipidemias, Nephrotic SyndromeDeregulated Nutrient SensingDyslipidemia contributes to increased cardiovascular risk in nephrotic syndrome.19397474
Hyperlipidemia, Glucose Intolerance (disease), Hepatitis CDeregulated Nutrient SensingGlucose intolerance has been associated with HCV infection and treating hyperlipidemia in this and other high-risk groups is warranted.19398918
HyperglycemiaDeregulated Nutrient SensingPatients may develop hyperglycemia due to a combination of surgical stress and postoperative insulin resistance.19399583
Diabetes MellitusDeregulated Nutrient SensingUnderstanding the role of insulin resistance in type 1 diabetes may lead to new prevention strategies.19401372
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingEstimates of insulin resistance in first-degree relatives of those with type 1 diabetes may be obtained using the minimal model of glucose kinetics incorporating a population approach.19401372
Diego blood group systemDeregulated Nutrient SensingThe increase IGI(30) was apparently insufficient to compensate for the insulin resistance because DI decreased linearly at the rate of 0.035 (10(-2) min(-1) mmol(-1) liter per year) after young adulthood.19401372
ObesityDeregulated Nutrient SensingPhysical inactivity and obesity underlie the insulin resistance of aging.19401446
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2 diabetes in older adults.19401446
ObesityDeregulated Nutrient SensingWe examined a corollary hypothesis that obesity and level of chronic physical inactivity are the true causes for this ostensible effect of aging on insulin resistance.19401446
ObesityDeregulated Nutrient SensingCONCLUSIONS Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity.19401446
TG gene, DyslipidemiasDeregulated Nutrient SensingFasting triglyceride (TG) concentrations are an unreliable index of fructose-induced dyslipidemia.19403712
AtherosclerosisDeregulated Nutrient SensingAlso, adipocyte-derived protein adiponectin, especially its high molecular weight (HMW) form, has been reported to have beneficial effects on insulin resistance and atherosclerosis.19403983
ETV3 wt Allele, ObesityDeregulated Nutrient SensingIn addition to insulin resistance and obesity, baPWV was strongly related to MetS in middle-aged Taiwan Chinese.19403990
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOlder age, higher body mass index, male gender, diabetes, hypertension and dyslipidaemia all increased the likelihood of the CAP burden at univariable analysis (p<0.001).19406736
Pancreatitis, DyslipidemiasDeregulated Nutrient SensingThe relationship between pancreatitis and dyslipidaemia is unclear.19407479
Unknown (origin) (qualifier value), Pancreatitis, Dyslipidemias, Biliary calculiDeregulated Nutrient SensingThe pancreatitis was associated with alcohol (63%), gallstones (18%), idiopathic (9%) and isolated dyslipidaemia (10%).19407479
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was significantly different between the two predominant race groups: Indian 50.5% and African 17.9% (p < 0.000017).19407479
DyslipidemiasDeregulated Nutrient SensingSeventy-eight (34%) had associated dyslipidaemia and 152 (66%) were normolipaemic at admission.19407479
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingAdverse outcomes in those with dyslipidaemia were predominantly associated with hypertriglyceridaemia.19407479
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingSingle-pill amlodipine/atorvastatin targets the two most common modifiable cardiovascular risk factors, hypertension and dyslipidaemia.19407658
Dyslipidemias, Carotid Intima-Media ThicknessDeregulated Nutrient SensingStudy of the relationship between carotid intima-media thickness and traditional Chinese medicine syndrome of dyslipidemia.19407948
Dyslipidemias, Upper respiratory tract mucus, Blood StasisDeregulated Nutrient SensingAccording to the theory of the TCM syndrome, 152 dyslipidemia patients were assigned to 4 groups: the stagnation of phlegm (SP) group, the blood stasis blocking channels (BSBC) group, the stagnation of phlegm and blood (SPB) group and the non-stagnation of phlegm and blood (NSPB) group.19407948
TG gene, DyslipidemiasDeregulated Nutrient SensingCarotid IMT, TG and blood rheology were closely correlated with the TCM syndrome of dyslipidemia.19407948
Apolipoproteins, DyslipidemiasDeregulated Nutrient SensingVisceral fat is better associated than fat mass with atherogenic dyslipidemia and, in men, with apolipoprotein B.19411085
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension was documented in 577 (92.2%) patients, dyslipidemia in 266 (42.5%) and mortality from all causes in 86 (13.7%).19414942
Hyperhomocysteinemia, DyslipidemiasDeregulated Nutrient SensingFurther tests found out dyslipidemia, hyperhomocysteinemia, impaired glucose tolerance.19415447
Glucose Intolerance (disease), Hepatitis CDeregulated Nutrient SensingPatients with hepatitis C virus (HCV) frequently show glucose intolerance.19422477
Glucose Intolerance (disease), Hepatocarcinogenesis, FAM126A geneDeregulated Nutrient SensingThey were also screened for HCC and, thereafter, the rate of hepatocarcinogenesis was compared between the patients with and without glucose intolerance.19422477
Dyslipidemias, ObesityDeregulated Nutrient SensingAmong Asians, including Japanese, obesity is related to dyslipidemia and insulin resistance at a lower level of body mass index (BMI) compared with non-Hispanic whites (NHW).19428036
Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.19430421
Primary malignant neoplasm, ObesityDeregulated Nutrient SensingIn addition, SIRT1 may be involved in the well-known link between obesity, cellular energy balance and cancer.19430421
Primary malignant neoplasmDeregulated Nutrient SensingHowever, a comprehensive study of SIRT1 using human cancer tissue with clinical outcome data is currently lacking, and its prognostic significance is uncertain.19430421
Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingUsing the database of 485 colorectal cancers in two independent prospective cohort studies, we detected SIRT1 overexpression in 180 (37%) tumors by immunohistochemistry.19430421
NeoplasmsDeregulated Nutrient SensingSIRT1 was not significantly related with age, sex, tumor location, stage, signet ring cells, cyclooxygenase-2 (COX-2), LINE-1 hypomethylation, KRAS, BRAF, BMI, PIK3CA, HDAC, p53, beta-catenin, COX-2, or patient prognosis.19430421
NeoplasmsDeregulated Nutrient SensingIn conclusion, SIRT1 expression is associated with CIMP-high MSI-high colon cancer, suggesting involvement of SIRT1 in gene silencing in this unique tumor subtype.19430421
Glucose Intolerance (disease), Hypertension, CTCAE, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingOf the 338 cases, 32 people had diabetes (DM, 9.46%), 78 people had glucose intolerance (IGT, 23.1%), and 228 people had only hypertension but not IGT and DM (67.4%).19430550
Dyslipidemias, Cerebrovascular accident, Coronary heart disease, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingInformation on CVD/CVD risk factors (coronary heart disease, cerebrovascular accident, diabetes, hypertension or dyslipidemia) was self-reported.19432034
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingExercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance.19433800
Hypertensive disease, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingIt appears that all classical risk factors (HBP, Diabetes, obesity, tobacco use, sedentary, menopause, contraceptives, dyslipidemia) were found among patients.19434980
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingSuch alterations were not observed in group C. It appears that dietetic supplementation with coconut oil does not cause dyslipidemia and seems to promote a reduction in abdominal obesity.19437058
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe asymptomatic subjects without CAD formed Group A, and were subdivided into A1 (without hypertension, dyslipidemia and/or diabetes) and A2 (with hypertension, dyslipidemia and/or diabetes).19438151
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe coronary patients formed Group B, who were also subdivided into B1, without these classic risk factors, and B2 with hypertension, dyslipidemia and/or diabetes.19438151
Lichen Planus, DyslipidemiasDeregulated Nutrient SensingLichen planus and dyslipidaemia: a case-control study.19438850
Dyslipidemias, PsoriasisDeregulated Nutrient SensingPrevious reports have demonstrated an association between psoriasis and dyslipidaemia.19438850
Lichen Planus, Dyslipidemias, Inflammatory disorderDeregulated Nutrient SensingAs lichen planus (LP) is also a chronic inflammatory disorder, we investigated the association between LP and dyslipidaemia in Israel.19438850
DyslipidemiasDeregulated Nutrient SensingIn the present study, LP was found to be associated with dyslipidaemia.19438850
AtherosclerosisDeregulated Nutrient SensingWe investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis.19439511
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia was detected in 73% of the CHD subjects vs. 46% of the non-CHD ones (p = 0.00001); its severity differing regionally.19441674
Inflammation, Prediabetes syndromeDeregulated Nutrient SensingCommunity-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population.19442860
Liver CirrhosisDeregulated Nutrient SensingPartial splenic embolization reverses insulin resistance in patients with liver cirrhosis.19443968
Liver Cirrhosis, Diabetes MellitusDeregulated Nutrient SensingIt is well known that patients with liver cirrhosis often develop insulin resistance and diabetes mellitus.19443968
Liver CirrhosisDeregulated Nutrient SensingConclusion PSE significantly reverses insulin resistance in patients with liver cirrhosis.19443968
AtherosclerosisDeregulated Nutrient SensingThe data source for this study is the Insulin Resistance Atherosclerosis Family Study (IRASFS), which consists of Hispanic- and African-American families from three US recruitment centers (n =1,334).19444222
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance, histologic features of fatty liver disease, and weight change were associated with outcomes of chronic hepatitis C. Improvement in these weight-related factors might modify disease progression.19445938
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone, a peroxisome proliferator-activated receptor gamma agonist, not only improves insulin resistance and glycemic control, but may also have additional beneficial vascular effects in patients with type 2 diabetes mellitus.19446110
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingCardiovascular risk factors (CVRFs) such as high blood pressure, hyperglycemia, and dyslipidemia were estimated in each group.19446112
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingAs might be expected, the prevalences of high blood pressure, hyperglycemia, and dyslipidemia were lowest in group 1 and were highest in group 4.19446112
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingModel-based simulation to explore the cost-effectiveness of following practice guidelines for triglyceride and low-density lipoprotein cholesterol control among patients with diabetes mellitus and mixed dyslipidemia.19446159
Dyslipidemias, Demographics Domain, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe results of this model simulation suggest that for patients with DM and mixed dyslipidemia, following treatment guidelines rather than current practice (including combination therapy rather than monotherapy) would result in more patients achieving lipid targets, fewer CHD events, and more QALYs gained at a reasonable cost (less than $109,000) per QALY.19446159
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingAmong the cardiovascular risk factors taken into account, only glucose intolerance and, to a lesser extent, obesity, were associated with worse performance in stabilometric tests, independent of age and sex.19448385
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia treatment of patients with diabetes mellitus in a US managed care plan: a retrospective database analysis.19450274
Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingTo evaluate real-world pharmacologic treatment of mixed dyslipidemia in patients with diabetes mellitus (DM).19450274
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingDM patients (N = 53,679) with mixed dyslipidemia were defined as having any 2 suboptimal lipid parameters (N = 28,728).19450274
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingOver 40% of DM patients with mixed dyslipidemia received no lipid-modifying therapy during the follow-up period.19450274
Traumatic injuryDeregulated Nutrient SensingSurgical trauma causes stress and inflammatory reactions with elevated serum free fatty acids (FFA) and glucose levels characteristic of intraoperative insulin resistance.19454546
Cyclophosphamide/Vincristine/Dacarbazine Regimen, AtherosclerosisDeregulated Nutrient SensingCentralized adiposity, insulin resistance, excess iron, and elevated oxidative stress place postmenopausal women at risk for atherosclerotic cardiovascular disease (CVD).19456248
Cardiovascular DiseasesDeregulated Nutrient SensingThe objective was to assess whether high energy supplementation in nondiabetic hemodialysis patients might adversely affect insulin resistance -- a known risk factor for cardiovascular disease.19458017
InflammationDeregulated Nutrient SensingHigh energy supplementation, because it increases adiposity and inflammation, exacerbates insulin resistance.19458017
Weight Gain, Hypertension, CTCAE, Posttransplant diabetes mellitus, DyslipidemiasDeregulated Nutrient SensingMain CVR factors analyzed were: hypertension, dyslipidemia, posttransplant diabetes mellitus, and weight gain.19460509
Hypertension, CTCAEDeregulated Nutrient SensingIt has been demonstrated that insulin resistance is associated with morning hypertension.19462498
Hypertension, CTCAE, ciliary vesicle, Dyslipidemias, ObesityDeregulated Nutrient SensingOn multivariate analysis, increased IMT was significantly and independently associated with hypertension, dyslipidemia, obesity, family history of CV disease, and age.19463515
Inflammation, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingT2DM is associated with obesity, hypertension, dyslipidemia, hypothalamic pituitary adrenocortical (HPA) axis abnormalities and inflammation, all of which have been shown to negatively impact the brain.19463794
Dyslipidemias, ObesityDeregulated Nutrient SensingDiminished cortisol suppression after dexamethasone and dyslipidemia were associated with decreased cognitive performance, whereas obesity was negatively related to hippocampal volume.19463794
Albrights hereditary osteodystrophy", Hypocalcemia, Hypothyroidism, Somatotropin deficiencyDeregulated Nutrient SensingPseudohypoparathyroidism type 1a in a patient with Albright hereditary osteodystrophy, characterized by hypocalcemia, hypothyroidism, growth-hormone deficiency and insulin resistance.Management.19465898
Ischemic myocardial dysfunctionDeregulated Nutrient SensingB-type natriuretic peptide levels and insulin resistance in patients with severe ischemic myocardial dysfunction.19468263
Dyslipidemias, Fatty degeneration, Diabetes Mellitus, Hepatitis B, ObesityDeregulated Nutrient SensingIn the group of chronic hepatitis B with steatosis, the prevalence of obesity, diabetes mellitus, dyslipidaemia, alcoholic consumption, the BMI, cholesterol, triglyceride, UA and FSG levels were significantly higher than those in the group without steatosis (P < 0.01).19469163
Adenoma of large intestineDeregulated Nutrient SensingNoninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas.19470793
Dyslipidemias, Haiti, Diabetes MellitusDeregulated Nutrient SensingNone of HT, dyslipidemia, and cigarette smoking was a significant risk factor for ED after adjusted for age and duration of diabetes.19473477
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingCoronary heart disease and dyslipidemia: a cross-sectional evaluation of prevalence, current treatment, and clinical control in a large cohort of Spanish high-risk patients: the PRINCEPS study.19476579
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with type 2 diabetes (T2DM) typically exhibit a pattern of dyslipidemia with high triglycerides, low HDL cholesterol, and small LDL particles.19477539
Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThird national Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) in Iran: methods and results on prevalence of diabetes, hypertension, obesity, central obesity, and dyslipidemia.19480675
Hypertriglyceridemia, ObesityDeregulated Nutrient SensingLDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress.19481310
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingForty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ.19481324
Diabetes MellitusDeregulated Nutrient SensingSingle nucleotide polymorphisms (SNPs) of the adiponectin gene have been reported to be associated with insulin resistance and the prevalence of type-2 diabetes.19484180
Diabetes MellitusDeregulated Nutrient SensingAdiponectin SNP sites were investigated at +45 of exon 2 and at +276 of intron 2; these sites have been thought to be associated with diabetes or insulin resistance.19484180
Fibrosis, Liver, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAdiponectin SNPs were found to be associated with the progression of liver fibrosis and insulin resistance, suggesting that adiponectin SNPs might play roles in the occurrence and progression of NAFLD.19484180
Dyslipidemias, Biliary calculi, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingGallstone heredity, dyslipidaemia, type 2 diabetes mellitus and metabolic syndrome increased the risk for GD in controls vs HCV patients.19486279
Hepatobiliary Disorder, Fibrosis AssessmentDeregulated Nutrient SensingIts relation to hepatic fibrosis and insulin resistance in post-hepatitis liver disease is not clear.19486470
Fibrosis AssessmentDeregulated Nutrient SensingAs fibrosis did not correlate with insulin resistance (r = 0.081, P = 0.204), the correlation between total adiponectin and fibrosis was not mediated by insulin resistance.19486470
Fibrosis AssessmentDeregulated Nutrient SensingWe can conclude that total adiponectin level, in HCV genotype 4 patients, increases with progression of hepatic fibrosis regardless of insulin resistance.19486470
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingAdherence to the DASH Diet is inversely associated with incidence of type 2 diabetes: the insulin resistance atherosclerosis study.19487638
AtherosclerosisDeregulated Nutrient SensingFive-year change in visceral adipose tissue quantity in a minority cohort: the Insulin Resistance Atherosclerosis Study (IRAS) family study.19487643
Dyslipidemias, ObesityDeregulated Nutrient SensingHowever, the finding of low prevalence of obesity and dyslipidemia at the onset of illness suggests that the increased frequency of these abnormalities in patients is an effect of their antipsychotic medication.19497246
Failure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBoth large neutral amino acids and fatty acids were related to an appropriate pancreatic response, suggesting that these metabolic intermediates might play a role in the progression to type 2 diabetes, one by contributing to insulin resistance and the other to pancreatic failure.19502541
Myotonic DystrophyDeregulated Nutrient SensingInsulin resistance is mainly present in skeletal muscle in non-obese patients with myotonic dystrophy.19506327
palladiumDeregulated Nutrient Sensingbeta-Cell function is maintained after a PD, whereas the improvement of insulin resistance may cause a short-term transient improvement of the glucose metabolism after the operation.19506534
Dyslipidemias, diabeticDeregulated Nutrient SensingRecent data on the management of cardiovascular risk factors in high risk patients showed that dyslipidemia is still treated in an inadequate way, especially in diabetic patients.19506537
Diabetes MellitusDeregulated Nutrient SensingIncreased retinol-binding protein 4 (RBP4) has been reported in association with insulin resistance and type 2 diabetes.19506831
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingRBP4 was associated with a higher risk for impaired glucose regulation (OR 1.011 for each 1 microg/ml increase in RBP4, 95% CI 1.000-1.022, p = 0.04) after adjustment for sex, age, BMI, current smoking and alcohol intake, family history of diabetes, insulin resistance, triacylglycerol, total cholesterol, and HDL- and LDL-cholesterol; the corresponding OR of combined impaired glucose regulation and type 2 diabetes was 1.022 (95% CI 1.009-1.035, p = 0.0009).19506831
Diabetes Mellitus, Non-Insulin-Dependent, Smoking, Diabetes MellitusDeregulated Nutrient SensingSmoking is an independent risk factor for type 2 diabetes mellitus and showed synergistic interaction with the status of low insulin secretion and high insulin resistance for developing diabetes.19508609
Stomach CarcinomaDeregulated Nutrient SensingExpression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.19509139
Malignant NeoplasmsDeregulated Nutrient SensingSIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers.19509139
Stomach Carcinoma, Breast CarcinomaDeregulated Nutrient SensingWe therefore investigated the expression levels of SIRT1 and its negative regulator, DBC1 (deleted in breast cancer 1), in gastric cancer patients.19509139
Stomach Carcinoma, NeoplasmsDeregulated Nutrient SensingWe evaluated immunohistochemical expression of DBC1, SIRT1, and p53 using 3-mm tumor cores from 177 gastric cancer patients for tissue microarray.19509139
Neoplasm Metastasis, Neoplasms, Venous InvasionDeregulated Nutrient SensingExpression of DBC1 was significantly correlated with tumor stage (P = 0.007), lymph node metastasis (P < 0.001), tumor invasion (P = 0.001), venous invasion (P = 0.001), histologic types (P < 0.001), p53 expression (P < 0.001), and SIRT1 expression (P < 0.001).19509139
Neoplasm Metastasis, NeoplasmsDeregulated Nutrient SensingSIRT1 expression was also significantly correlated with tumor stage (P < 0.001), lymph node metastasis (P < 0.001), tumor invasion (P < 0.001), histologic types (P < 0.001), and p53 expression (P = 0.001).19509139
Stomach CarcinomaDeregulated Nutrient SensingThis study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients.19509139
Chronic diseaseDeregulated Nutrient SensingPermanent impairment of insulin resistance from pregnancy to adulthood: the primary basic risk factor of chronic Western diseases.19515499
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWaist circumference cutoffs were higher for women than men for hypertension, diabetes mellitus, and dyslipidemia.19526180
Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Failure (biologic function)Deregulated Nutrient SensingFactors significantly associated with an increased risk of failure to achieve goals were obesity, dyslipidemia, family histories of diabetes mellitus or hypertension, and number of antihypertensive drugs used.19527324
diabeticDeregulated Nutrient SensingIn all diabetic patients, multiple regression analysis showed that HbA1c, fasting insulin, and homeostasis model assessment-insulin resistance index were independently associated with plasma FGF-21 levels.19528204
Myalgia, DyslipidemiasDeregulated Nutrient Sensing62 patients with dyslipidemia and history of discontinuation of statin therapy due to myalgias.19528562
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and type 2 diabetes are associated with elevated intramyocellular lipids (IMCLs) and insulin resistance.19531593
Weight decreasedDeregulated Nutrient SensingDespite greater weight loss in the hypocaloric group (-7.7 +/- 0.5 vs. -3.3 +/- 0.7%, P < 0.001), FFA-induced peripheral insulin resistance was improved equally in both groups.19531640
Weight decreasedDeregulated Nutrient SensingWe conclude that the exercise-induced improvement in FFA-induced insulin resistance is independent of the magnitude of weight loss and FFA turnover, yet it is linked to increased intracellular FFA utilization.19531640
Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingPitavastatin significantly improved fasting and postprandial dyslipidemia and endothelial dysfunction in CAD patients, partly via reducing oxidative stress and increasing plasma adiponectin, although rheological parameters remained unchanged.19531904
Diabetes MellitusDeregulated Nutrient SensingAlthough g/g homozygotes are diabetes prone, improvement of the insulin resistance by restricting the intakes of both carbohydrate-rich foods and cane sugar may be easier in g/g than in t/g and t/t.19533865
Immature, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAmong blacks, dyslipidemia, diabetes, and smoking were independently associated with premature CAD.19534020
Immature, DyslipidemiasDeregulated Nutrient SensingAmong Hispanics, dyslipidemia, male sex, and family history of CAD were independently associated with premature CAD.19534020
muscle massDeregulated Nutrient SensingSkeletal muscles are responsible for approximately 75% of insulin stimulated whole body glucose disposal and therefore insulin resistance could underlie the relation between muscle mass and CVD.19535078
muscle massDeregulated Nutrient SensingWe aimed to determine whether muscle mass, as reflected by 24h urinary creatinine excretion, is associated with CVD and whether this depends on insulin resistance.19535078
AtherosclerosisDeregulated Nutrient SensingContribution of subcutaneous fat accumulation to insulin resistance and atherosclerosis in haemodialysis patients.19535435
AtherosclerosisDeregulated Nutrient SensingWhereas visceral fat accumulation (VFA) is related to insulin resistance and atherosclerosis in both haemodialysis (HD) patients and the general population, little is known about the role of subcutaneous fat accumulation (SFA).19535435
HD Term Type, AtherosclerosisDeregulated Nutrient SensingIt appears that there is a close relationship between SFA and insulin resistance or atherosclerosis in HD patients.19535435
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffect of ABCA1 variant on atherogenic dyslipidaemia in patients with Type 2 diabetes treated with rosiglitazone.19538231
Fibrosis Assessment, InsulinDeregulated Nutrient SensingAlthough cystic fibrosis-related diabetes (CFRD), a poor prognostic factor in cystic fibrosis (CF), is characterized by insulinopenia, the role of insulin resistance is unclear.19538232
Cystic Fibrosis Pulmonary ExacerbationDeregulated Nutrient SensingCFRD is characterized by qualitative and quantitative defects in insulin secretion, but not insulin resistance, and is associated with increased hospital admissions for pulmonary exacerbations.19538232
Diabetes MellitusDeregulated Nutrient SensingIn men without previously diagnosed diabetes, fasting insulin (P = 0.035), 2-h glucose concentrations (P = 0.028) and insulin resistance (P = 0.032) were significantly associated with HAD-D scores.19538241
IschemiaDeregulated Nutrient SensingIn short-term studies, testosterone replacement therapy has been shown to protect male subjects from exercise-induced ischaemia and modify cardiovascular risk factors such as insulin resistance, fat mass and lipid profiles.19542238
Critical IllnessDeregulated Nutrient SensingBlood glucose levels and insulin resistance in critically ill patients on admission to intensive care units (ICUs) have been identified as factors influencing mortality.19545363
Critical IllnessDeregulated Nutrient SensingThe pathogenesis of insulin resistance (IR) in critically ill patients is complex and not fully understood.19545363
Critical Illness, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, ObesityDeregulated Nutrient SensingIn non-critically ill patients, resistin was found to be related to impaired glucose tolerance, insulin resistance, metabolic syndrome, obesity and type 2 diabetes.19545363
Inflammation, Critical IllnessDeregulated Nutrient SensingTherefore, resistin might represent a link between inflammation, acute phase response and insulin resistance in critically ill patients.19545363
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingWe observed a high prevalence of chronic kidney disease, hypertension, dyslipidemia, and obesity among renal transplant patients.19545697
Polycystic Ovary SyndromeDeregulated Nutrient Sensing[Cardiovascular risk markers in polycystic ovary syndrome in women with and without insulin resistance].19547885
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient SensingSimilarly, it is unknown whether stress hyperglycaemia predicts future glucose intolerance.19549250
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient Sensinglower cortisol), hyperglycaemia is more likely to reflect underlying glucose intolerance.19549250
Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt could be concluded that atorvastatin with its pleiotropic effects could provide optimal therapeutic intervention to control not only dyslipidemia, but also oxidative stress status with consequent improvement in the course of type 2 diabetes and diabetic nephropathy.19553142
Glucose Intolerance (disease)Deregulated Nutrient SensingA role for this enzyme in combating glucose intolerance was further supported by the finding that CrAT overexpression in primary human skeletal myocytes increased glucose uptake and attenuated lipid-induced suppression of glucose oxidation.19553674
Proteinuria, Microscopic hematuria, Dyslipidemias, Hypertensive (finding)Deregulated Nutrient SensingThe latter hypothesis is supported by evidence that (a) NAS and IN share a relative aspecificity in their clinical symptoms (low proteinuria, microhematuria, high blood pressure, dyslipidemia) and histopathological features (as determined in the few cases that undergo a kidney biopsy), and (b) there is a high likelihood that atheromatous and hypertensive lesions coexist in the same patient.19554527
DyslipidemiasDeregulated Nutrient SensingThe present study suggested that screening for elevated s-CK levels in initially healthy Japanese subjects was useful to predict first-ever MI in the future, especially in subjects with dyslipidaemia.19556328
Sepsis, HyperglycemiaDeregulated Nutrient SensingInsulin resistance and hyperglycaemia are common in severe sepsis.19556617
Sepsis, HyperglycemiaDeregulated Nutrient SensingA common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis.19556617
Prediabetes syndrome, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCosts for subjects with diabetes plus weight risk, dyslipidemia, and hypertension were almost double the costs for subjects with prediabetes plus similar risk factors ($8,067 vs. $4,638).19558267
Myocardial Ischemia, Cerebrovascular accidentDeregulated Nutrient SensingIs insulin resistance related to recurrence of stroke or incident of ischemic heart disease in patients with stroke?19560684
Myocardial Ischemia, Atherosclerosis, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance promotes atherosclerosis and has been recognized as an important risk factor for both stroke and ischemic heart disease (IHD).19560684
Myocardial Ischemia, Ischemic strokeDeregulated Nutrient SensingHowever, the precise relationship between insulin resistance and ischemic stroke recurrence or development of IHD is uncertain.19560684
Myocardial Ischemia, Ischemic strokeDeregulated Nutrient SensingThis study suggests that insulin resistance in combination with decreased insulin secretion may be associated with ischemic stroke recurrence or IHD.19560684
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn overweight/obese patients with PCOS, lower-abdomen and upper-back SAT showed significant positive correlations with insulin resistance.19562283
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThere was no correlation of SAT topography with insulin resistance in lean women with PCOS.19562283
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIncreased SAT layers on the trunk are associated with insulin resistance, impaired glucose tolerance and an unfavorable lipid profile in women suffering from PCOS.19562283
Prostate Cancer Outcomes Study, Truncal obesity, Glucose Intolerance (disease)Deregulated Nutrient SensingCompared with PCOS women with normal glucose tolerance, patients with glucose intolerance had significantly increased trunk obesity and decreased leg fat.19562283
AtherosclerosisDeregulated Nutrient SensingHence, we hypothesize that SIRT1 is a key regulator in the pathogenesis of atherosclerosis and that upregulation of SIRT1 in endothelial cells may mimic CR's beneficial effect on vascular health.19562740
AtherosclerosisDeregulated Nutrient SensingWe infer that SIRT1 may be a novel target for atherosclerosis prevention and treatment.19562740
Liver StiffnessDeregulated Nutrient SensingInsulin resistance is a major determinant of liver stiffness in nondiabetic patients with HCV genotype 1 chronic hepatitis.19563503
Fibrosis, Liver, Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingConclusions In nondiabetic patients with genotype 1 CHC, insulin resistance, gammaGT and platelet levels contribute to LSM independently of liver fibrosis.19563503
NeoplasmsDeregulated Nutrient SensingActivation of AMPK can suppress tumor formation and inhibit cell growth in addition to lowering blood glucose levels.19564453
Acute lymphocytic leukemia, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia.19564534
Acute lymphocytic leukemia, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo determine the prevalence of insulin resistance and other risk factors for cardiovascular disease (CVD) in young adult survivors of childhood acute lymphoblastic leukemia (ALL).19564534
Acute lymphocytic leukemiaDeregulated Nutrient SensingALL survivors had an increased prevalence of insulin resistance in comparison with a cohort of older individuals from the same community.19564534
Lipolysis, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8, Diabetes MellitusDeregulated Nutrient SensingBecause GH stimulates lipolysis, an increase in circulating free fatty acid levels, as opposed to a direct effect of high GH levels, could underlie the development of insulin resistance in type 1 diabetes (T1D).19567515
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Deregulated Nutrient SensingOur aim was to explore the relative contributions of GH and free fatty acids to the development of insulin resistance in patients with T1D.19567515
Dyslipidemias, Obesity, Blood GlucoseDeregulated Nutrient SensingErythrocyte acid phosphatase (ACP locus 1), also known as low-molecular-weight protein tyrosine phosphatase, has previously been associated to glycemia, dyslipidemia, and obesity.19570551
ObesityDeregulated Nutrient SensingThe evidence for pleiotropic control of insulin and central obesity-related traits supports the presence of an insulin resistance syndrome in South Asians with a tendency for central obesity.19570552
ObesityDeregulated Nutrient SensingGlucocorticoids play an important role in the pathogenesis of obesity and insulin resistance.19571556
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance among Brazilian schoolchildren: association with risk factors for cardiovascular diseases.19572942
Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingSixty-nine point six percent of the diabetes mellitus (DM) inpatients was accompanied with dyslipidemia and the rate was higher than those in NGT (56.4%) and IGR inpatients (52.5%, P < 0.05, respectively).19576085
DyslipidemiasDeregulated Nutrient SensingOnly 22.8% of the PDM inpatients underwent treatment of dyslipidaemia and just 3.4% achieved the target suggested by the guideline of ATP-III.19576085
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFlushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease.19576324
InflammationDeregulated Nutrient SensingIn conclusion, these results suggest that the previously reported association between poor fitness and low-grade inflammation may be largely attributable to increased visceral AT accumulation and its associated state of insulin resistance, conditions frequently observed in subjects with poor cardiorespiratory fitness.19576354
Overweight, ObesityDeregulated Nutrient SensingMultivariate analysis found risk factors associated to insulin resistance for non-diabetic adults with low income and educational level: overweight, obesity, elevated waist-to-hip ratio, C-reactive protein and skin color.19578594
Hypertension, CTCAEDeregulated Nutrient SensingImpact of abdominal fat and insulin resistance on arterial hypertension in non-obese women.19578595
Hypertension, CTCAEDeregulated Nutrient SensingTo evaluate the impact of abdominal fat and insulin resistance on arterial hypertension of non-obese women.19578595
Hypertension, CTCAEDeregulated Nutrient SensingArterial hypertension in non-obese women is associated with insulin resistance, central fat distribution and higher leptin levels.19578595
Increased insulin level, Nail-Patella Syndrome, DyslipidemiasDeregulated Nutrient SensingThese patients with NPS did not show hyperinsulinemia or dyslipidemia.19579756
Dyslipidemias, Breast CarcinomaDeregulated Nutrient SensingThis study confirms the association between dyslipidaemia, BMI and increased breast cancer risk.19579966
ETV3 wt AlleleDeregulated Nutrient SensingIMT increased 79+/-7 mum (mean+/-SEM) in subjects with MetS according to the MetS/European Group for the Study of Insulin Resistance definition and 42+/-2 mum in subjects without MetS (P<0.0001).19581494
Cardiac complication, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is common in type 1 diabetes patients and is associated with microvascular complications.19584183
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is associated with obesity and insulin resistance.19584882
Non-alcoholic Fatty Liver Disease, AtherosclerosisDeregulated Nutrient SensingThe aims of this study were to examine the risk factors and heritability of NAFLD in 795 Hispanic American and 347 African-American adults participating in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.19584882
Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingIn subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.19584917
Malignant neoplasm of endometriumDeregulated Nutrient SensingCoffee drinking has been reported to have beneficial effects on insulin resistance, which has been directly associated with endometrial cancer.19585497
Hepatobiliary Disorder, Hepatitis C, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance is observed more in patients with HCV infection compared with control subjects with liver disease, Initial studies suggested that Hepatitis C virus infection may be an additional risk factor for the development of diabetes mellitus.19586535
Primary malignant neoplasmDeregulated Nutrient SensingLaparoscopic surgery improves blood glucose homeostasis and insulin resistance following distal gastrectomy for cancer.19587383
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes.19587831
HyperinsulinismDeregulated Nutrient SensingSupraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism.19588121
HyperinsulinismDeregulated Nutrient SensingWe hypothesised that the age-related defect in muscle protein anabolism is a true insulin resistance state and can be overridden by supraphysiological hyperinsulinaemia.19588121
HyperinsulinismDeregulated Nutrient SensingWe conclude that supraphysiological hyperinsulinaemia is necessary to stimulate muscle protein synthesis and anabolic signalling in healthy older individuals, suggesting the existence of a true age-related insulin resistance of muscle protein metabolism.19588121
Inflammation, Glucose Intolerance (disease), Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity leads to increased risk of cardiovascular disease and glucose intolerance, which are phenomena of chronic inflammation.19588793
Critical IllnessDeregulated Nutrient SensingCritically ill patients requiring intensive care uniformly develop insulin resistance.19589139
Hypertensive (finding)Deregulated Nutrient SensingSoluble CD40 ligand levels in essential hypertensive men: evidence of a possible role of insulin resistance.19590499
Dyslipidemias, Splenomegaly, Kidney DiseasesDeregulated Nutrient SensingSplenomegaly with sea-blue histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol acyltransferase deficiency: a clinicopathologic correlation.19592052
Lecithin Acyltransferase Deficiency, Dyslipidemias, Splenomegaly, Kidney DiseasesDeregulated Nutrient SensingWe describe a case with the triad of splenomegaly with sea-blue histiocytes, nephropathy, and dyslipidemia in a patient with LCAT deficiency.19592052
Inflammation, Coronary Artery Disease, Endothelial dysfunctionDeregulated Nutrient SensingIn conclusion, insulin resistance, endothelial dysfunction, and inflammation are important cardiovascular risk factors in coronary artery disease patients; and L-arginine seems to have anti-inflammatory and metabolic advantages in these patients.19592054
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingInsulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes.19592624
Inflammation, Beta-cell dysfunctionDeregulated Nutrient SensingSubclinical inflammation leads to insulin resistance and beta-cell dysfunction.19592635
ObesityDeregulated Nutrient Sensing[Obesity and insulin resistance among adolescents from Chiapas].19593490
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis novel approach of improving muscle insulin resistance may be a potential alternative treatment for type 2 diabetes mellitus.19593542
Hyperglycemia, Glucose Intolerance (disease), Hyperinsulinism, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSkeletal myoblast transplantation for attenuation of hyperglycaemia, hyperinsulinaemia and glucose intolerance in a mouse model of type 2 diabetes mellitus.19593542
Non-ST Elevation Myocardial Infarction by ECG Finding, DyslipidemiasDeregulated Nutrient SensingThe non-STEMI patients were older, used more medication, had undergone more often coronary interventions, but did not differ with respect to risk factors, except for a higher incidence in dyslipidemia.19596303
Inflammation, Dyslipidemias, Kidney FailureDeregulated Nutrient SensingRenal failure is associated with dyslipidemia and inflammation in normal-weight patients.19596588
Dyslipidemias, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThese results suggest that primary prevention strategies for renal disease should focus on individuals with elevated blood pressure, diabetes mellitus, and dyslipidemia.19597042
Hypertension, CTCAE, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingCoronary heart disease, hypertension, and dyslipidemia are highly prevalent and commonly coexist in people who are middle-aged and older.19602720
Hepatitis C, ChronicDeregulated Nutrient SensingSerum HCV RNA levels and HCV genotype do not affect insulin resistance in nondiabetic patients with chronic hepatitis C: a multicentre study.19604179
Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Diabetes MellitusDeregulated Nutrient SensingChronic hepatitis C (CHC) induces insulin resistance (IR) and subsequently diabetes.19604179
Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingBoth insulin resistance (type II diabetes) and beta-amyloid (Abeta) oligomers are implicated in Alzheimer's disease (AD).19605645
Dyslipidemias, Blood Vessel, Lupus ErythematosusDeregulated Nutrient SensingIn systemic lupus erythematosus they were highly associated with inflammatory markers and dyslipidemia, and may ultimately contribute to vascular damage.19606253
Takayasu Arteritis, Dyslipidemias, Lupus ErythematosusDeregulated Nutrient SensingThe lack of anti-LPL antibodies in Takayasu's disease implies distinct mechanisms underlying dyslipidemia compared to systemic lupus erythematosus.19606253
Metabolic Syndrome X, ObesityDeregulated Nutrient SensingCentral obesity and insulin resistance in the cardiometabolic syndrome: pathways to preclinical cardiovascular structure and function.19614791
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes and dyslipidaemia were independent predictors of decreased primary patency (p=0.003 and p=0.014, respectively).19616976
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe extent of the disease, diabetes and dyslipidaemia are associated with worse outcome.19616976
Dyslipidemias, ObesityDeregulated Nutrient SensingFactors for most frequent risk were: obesity (56.8%), consumption of alcohol (22.1%) and dyslipidemia (13.4%).19617169
Polycystic Ovary Syndrome, Follicular cell of ovaryDeregulated Nutrient SensingThe relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome.19617605
Prostate Cancer Outcomes Study, Endocrine System Diseases, Polycystic Ovary SyndromeDeregulated Nutrient SensingHyperandrogenaemia and insulin resistance are prominent features of polycystic ovary syndrome (PCOS) and influence the process of folliculogenesis in women with the endocrinopathy.19617605
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe relationships between AMH and insulin resistance and androgenaemia in patients with and without PCOS were studied.19617605
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThese observations indicate that AMH is similarly related to insulin resistance and androgens in women with and without PCOS.19617605
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingFactors associated with insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes.19618346
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, flavin-hypoxanthine dinucleotideDeregulated Nutrient SensingTo investigate the changes of insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes mellitus (FHD) and analyze its related factors.19618346
Obesity, flavin-hypoxanthine dinucleotide, Diabetes MellitusDeregulated Nutrient SensingThis study showed that the subjects with FHD and obesity who are predisposed to diabetes have insulin resistance in adolescent stage.19618346
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingPatients underwent measurements of height, weight and waist circumference and provided data on reported cardiovascular disease (CVD), diabetes, hypertension and dyslipidaemia.19619215
ObesityDeregulated Nutrient SensingThe association of ghrelin with insulin resistance provides further evidence on the regulation of ghrelin in glucose homeostasis in childhood obesity at the prepubertal age.19619916
Dyslipidemias, Data types - AddressDeregulated Nutrient SensingOur study shows a higher prevalence of central adiposity, impaired glucose tolerance and dyslipidemia in AD patients.19620820
Beta-cell dysfunctionDeregulated Nutrient SensingAssociation of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects.19622625
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevious studies reported independent associations of hematological parameters with risk of incident type 2 diabetes, although limited data are available on associations of these parameters with insulin resistance (IR) and (especially) pancreatic beta-cell dysfunction in large epidemiological studies.19622625
Polycystic Ovary SyndromeDeregulated Nutrient SensingIndividuals are predisposed to insulin resistance and its complications, including features of polycystic ovary syndrome.19622949
Steatohepatitis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMetabolic testing identified diabetes mellitus, dyslipidemia, and steatohepatitis.19622949
Congestive heart failure, Dyslipidemias, Chronic disease, Diabetes MellitusDeregulated Nutrient SensingRisk factors for CHF were being on social assistance, diabetes, dyslipidaemia, higher chronic disease score and developing a cardiovascular condition during follow-up.19623691
Dyslipidemias, Diabetes Mellitus, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity was found in 40%, high blood pressure in 39%, dyslipidemia in 37%, diabetes mellitus in 10%, smoking in 7%, and cardiovascular disease in 6% of the patients.19627704
Prehypertension, Cardiovascular DiseasesDeregulated Nutrient SensingPrehypertension is associated with cardiovascular disease and insulin resistance.19628813
Alzheimers DiseaseDeregulated Nutrient SensingAcetylcholinesterase inhibition and insulin resistance in late onset Alzheimer's disease.19631004
Alzheimers Disease", Loading TechniqueDeregulated Nutrient SensingInsulin resistance (IR) may play a role in most pathogenic processes that promote the development of late onset Alzheimer's disease (LOAD).19631004
Hypertension, CTCAE, Kidney Failure, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingWomen, older mean age, hypertension, dyslipidemia, previous stroke and renal insufficiency were more prevalent in the D group.19634498
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased hepatocellular lipids relate to insulin resistance and are typical for individuals with type 2 diabetes mellitus (T2DM).19637187
Fatty degenerationDeregulated Nutrient SensingThese data suggest that impaired hepatic energy metabolism and insulin resistance could precede the development of steatosis in individuals with T2DM.19637187
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingObesity is associated with diabetes mellitus, hypertension, dyslipidemia and increased cardiovascular disease (CVD) risk.19638708
Autoimmune Diseases, Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingIt has been suggested that metabolic demand and insulin resistance play a role in the development of type 1 diabetes, including the onset of autoimmunity.19641897
Autoimmune DiseasesDeregulated Nutrient SensingThese findings are inconsistent with the notion that insulin resistance is a risk factor for islet autoimmunity.19641897
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingParticipants had an increased likelihood of hypertension (systolic blood pressure), dyslipidemia (elevated triacylglycerol and descending HDL-C) and diabetes mellitus at WHR > or = 0.84.19642371
Acute Coronary Syndrome, DyslipidemiasDeregulated Nutrient SensingBody mass and atherogenic dyslipidemia as major determinants of blood levels of B-type natriuretic peptides in Arab subjects with acute coronary syndromes.19642911
Dyslipidemias, Erectile dysfunctionDeregulated Nutrient SensingThe independent link with atherogenic dyslipidemia suggests that BNP is important in atherogenesis and may not be just an index of cardiac contractile dysfunction.19642911
Inflammation, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCurrent research has focused upon the potential links between novel markers of vascular risk such as endothelial dysfunction, oxidative stress, inflammation and insulin resistance in the pathogenesis of Type 2 diabetes and its complications.19646193
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingIn chronic kidney disease the contribution of decreased glomerular filtration rate (GFR) versus enhanced inflammation to cause insulin resistance (IR) is controversial.19648735
Kidney Failure, Chronic, Arterial StiffnessDeregulated Nutrient SensingPatients with end-stage renal disease are known to have insulin resistance and advanced arterial stiffness.19648738
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is a heterogeneous disease resulting from insulin resistance and/or from a beta-cell secretory defect.19651806
Fatty LiverDeregulated Nutrient SensingDissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene.19651814
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVisceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type.19656356
Ventricular FibrillationDeregulated Nutrient SensingIn contrast, EGP and the product of EGP and SSPI during the insulin clamp (an index hepatic insulin resistance) correlated positively with VF/SF ratio, but not with BMI, FM, VF or SF.19656356
ObesityDeregulated Nutrient SensingWe conclude that, independent of the individual's body type, visceral fat dominant accumulation as opposed to subcutaneous fat accumulation is associated with hepatic insulin resistance, whereas peripheral (muscle) insulin resistance is more closely related to general obesity (i.e.19656356
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia in patients with CKD has been recognized as a risk factor for disease progression but the role of triglycerides (TGs) remains controversial.19657271
Blood coagulation, Endothelial dysfunction, AtherosclerosisDeregulated Nutrient SensingThere was a statistically significant improvement in insulin resistance: M value 2.55 (1.92; 3.15) vs. 3.32 (2.23; 4.49) mg/kg per min (P<0.01), and improvement in atherosclerosis risk factors (blood coagulation and endothelial dysfunction): fibrinogen 3.44 (3.13; 3.86) vs. 3.24 (2.77; 3.38) g/l, factor VII 115 (101; 128) vs. 109 (93; 119)%, factor VIII 230 (148; 260) vs. 188 (126; 225)%, vWF:RiCo 162 (141; 193) vs. 128 (100; 132)%, PAI-1 39 (30; 44) vs. 30 (25; 36) AU/ml, thrombomodulin Ag 4.1 (3.7; 4.4) vs. 3.7 (3.45; 4.05) ng/ml (P<0.01).19657609
Blood coagulation, Endothelial dysfunctionDeregulated Nutrient SensingSix months of CSII treatment led to decrease in insulin resistance and improvement in parameters of lipid metabolism, blood coagulation and endothelial dysfunction independently of glycemic control and weight.19657609
Tumor necrosisDeregulated Nutrient SensingThe non-invasive laboratory markers measured were insulin resistance, tumor necrosis factor (TNF-alpha), type IV collagen and hyaluronic acid (HA).19659788
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease.19661128
ObesityDeregulated Nutrient SensingWe examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity.19661128
ObesityDeregulated Nutrient SensingIn older men, lower total testosterone is associated with insulin resistance independently of measures of central obesity.19661128
Acquired Immunodeficiency Syndrome, DyslipidemiasDeregulated Nutrient SensingTo determine the prevalence and pattern of dyslipidaemia and dysglycaemia amongst Nigerian HIV/AIDS patients on HAART.19662738
No metabolic abnormalities, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance (IR) has been proposed to be a key feature of metabolic abnormalities of hypertension and may precede the elevation of BP.19666708
AtherosclerosisDeregulated Nutrient SensingScavenger receptors play crucial roles in the pathogenesis of atherosclerosis, but their role in insulin resistance has not been explored.19667111
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingPioglitazone and adiponectin regulate gene expression of SRA and LOX-1, and this may have clinical implications in arresting the untoward sequalae of insulin resistance and diabetes, including accelerated atherosclerosis.19667111
Xanthoma, DyslipidemiasDeregulated Nutrient SensingRemission of the eruption after treatment of dyslipidemia confirmed the diagnosis of the eruptive xanthoma and motivated research about the histological similarities and differences between these diseases.19668945
Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingPrevalence and type of dyslipidaemia in a population at risk for cardiovascular death in Bulgaria.19670537
Acquired Immunodeficiency Syndrome, DyslipidemiasDeregulated Nutrient SensingThe prevalence rates of dyslipidemia and insulin resistance are high in Chinese HIV/AIDS patients receiving HAART, especially in the HIV-LD group.19671283
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingThe rate of hyperinsulinemia and any kind of dyslipidemia were 25.0% and 59.6%.19671283
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDefects in the AMPK system might therefore be an important factor in the pathogenesis of type 2 diabetes.19671840
ObesityDeregulated Nutrient SensingMultiple regression analyses indicated that skeletal muscle AMPK mRNA and protein expression as well as activity were regulated by sex, age, obesity, and aerobic capacity.19671840
ObesityDeregulated Nutrient SensingOur results suggest that skeletal muscle AMPK expression is under minor genetic control but regulated by age and sex and associated with obesity and aerobic capacity.19671840
Beta-Cell Function MeasurementDeregulated Nutrient SensingIntravenous glucose tolerance tests suggested impaired beta-cell function; no insulin resistance was observed.19673927
Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias, HyperlipidemiaDeregulated Nutrient SensingThe percentages of hypercholesterolaemia, hypertriglyceridaemia, combined dyslipidaemia, and hyperlipidaemia were 1.2, 8.8, 0.4, and 9.7%, respectively.19674498
Hyperlipidemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe incidences of hypertriglyceridaemia, combined dyslipidaemia, and hyperlipidaemia of girls were higher than boys.19674498
Demographics Domain, Osage language, Diabetes Mellitus, Glucose Intolerance (disease), Sleep Apnea, ObstructiveDeregulated Nutrient SensingAlthough obstructive sleep apnoea (OSA) has been linked to insulin resistance and glucose intolerance, it is unclear whether there is an independent association between OSA and diabetes mellitus (DM) and whether all patients with OSA are at risk.19679579
Obesity, Diabetes MellitusDeregulated Nutrient SensingRisk factors for AF, including aging, obesity, and diabetes, have been associated with insulin resistance that leads to depressed/defective PI3K signaling.19679877
HIV Infections, Alcoholic Intoxication, Chronic, Dyslipidemias, HIV, Bone necrosis, LipodystrophyDeregulated Nutrient SensingOsteonecrosis (ON) of the hip in human immunodeficiency virus (HIV)-infected patients has been related to corticosteroid use, dyslipidemia, alcoholism, lipodystrophy, antiretroviral drug use, and HIV infection, itself.19683365
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe tested the hypothesis that an elevated level of visceral fat accumulation (VFA) correlates with hippocampus volume and insulin resistance in non-dementia patients with type 2 diabetes.19683583
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results indicate that the elevated level of VFA in Japanese non-dementia patients with type 2 diabetes is characterized by increased hippocampus volume and insulin resistance, and that the Z-score and HOMA index are independent predictors of VFA.19683583
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this study, we sought to identify mutations in the insulin receptor (INSR) gene, which can cause insulin resistance in type II diabetic patients.19688022
Hyperlipidemia, IFNG wt AlleleDeregulated Nutrient SensingIn patients with IFG and hyperlipidaemia, rosuvastatin treatment was associated with a dose-dependent increase in insulin resistance.19691613
Inflammation, Fibrosis Assessment, Weight decreased, Fatty degenerationDeregulated Nutrient SensingThe combination of weight loss and antioxidant drugs to ameliorate insulin resistance and improve steatosis, inflammation and fibrosis provides the rational for therapeutic trials.19691668
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCardiovascular risk factors such as diabetes, hypertension, dyslipidaemia and smoking were determined during consultation.19693020
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, hypertension, dyslipidaemia and smoking were common cardiovascular risk factors among men with ED.19693020
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, hypertension, dyslipidaemia and smoking are common cardiovascular risk factors among men with ED.19693020
Non-cirrhoticDeregulated Nutrient SensingInsulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin.19695729
Ventricular FibrillationDeregulated Nutrient SensingAs bioavailable testosterone was associated with VF even after adjusting for insulin resistance, this suggests that it plays an important role in regional fat distribution.19696765
Obesity, AbdominalDeregulated Nutrient SensingThe subjects with central obesity, compared to the controls, after adjusting for age, race, and gender, had significantly greater diastolic blood pressure, mean arterial pressure, low-density lipoprotein cholesterol level, triglycerides, triglycerides/high-density lipoprotein cholesterol ratio, insulin, homeostasis model assessment of insulin resistance, uric acid, C-reactive protein, and liver function enzymes (alanine aminotransferase and gamma-glutamyl transferase).19699351
Dyslipidemias, Hypertension, CTCAE, Hyperuricemia, ObesityDeregulated Nutrient SensingThe central obesity group also had a greater prevalence of dyslipidemia, hypertension, insulin resistance, hyperuricemia, and elevated C-reactive protein.19699351
Prostate carcinomaDeregulated Nutrient SensingSerum insulin, glucose, indices of insulin resistance, and risk of prostate cancer.19700655
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingMild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study.19703913
Gestational Diabetes, Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingAlthough women with gestational diabetes have an increased risk of cardiovascular disease, it is not known whether mild glucose intolerance during pregnancy is also associated with cardiovascular disease.19703913
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingMild glucose intolerance in pregnancy may be associated with an increased risk of cardiovascular disease.19703913
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingPresence of corneal arcus in middle-aged men may be an indicator for dyslipidemia, and we speculate that the relationship between arcus and coronary heart disease may be dependent of dyslipidemia.19707111
Units Of Measure - SiemensDeregulated Nutrient SensingLower concentrations of hepatic enzymes, in particular, lower circulating ALT levels, in MHO individuals may reflect lower hepatic insulin resistance and lower liver fat content; and this could be involved, at least in part, in the protective profile of MHO individuals.19709695
ObesityDeregulated Nutrient SensingAssociations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance.19712485
ObesityDeregulated Nutrient SensingThe interrelationships between desaturase indices derived from different serum lipid fractions and adipose tissue are unclear, as well as their associations with obesity and insulin resistance.19712485
ObesityDeregulated Nutrient SensingSCD-1 activity index in adipose tissue is best reflected by 16:1/16:0-ratio in serum FFA, but associations with obesity and insulin resistance differ between these pools.19712485
ObesityDeregulated Nutrient SensingD5D in PL was inversely related to obesity and insulin resistance, whereas D6D index showed positive associations.19712485
Heart failureDeregulated Nutrient SensingAldosterone status associated with insulin resistance in patients with heart failure--data from the ALOFT study.19713201
Heart failure, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is a risk factor in heart failure and cardiovascular disease.19713201
Heart failureDeregulated Nutrient SensingThis study demonstrates a novel direct relation between aldosterone status and insulin resistance in heart failure.19713201
Dyslipidemias, Family history, AtherosclerosisDeregulated Nutrient SensingHowever, based on his advanced atherosclerosis, we cannot exclude the possibility that our patient may be accompanying dyslipidemia due to causes in addition to heterozygous FH.19713675
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingBecause omental adipose tissue has been strongly associated with the development of insulin resistance, type 2 diabetes and cardiovascular disease, we searched for proteins differentially expressed in these two fat depots using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) and mass spectrometry (MS).19714809
Communicable Diseases, DyslipidemiasDeregulated Nutrient SensingSide effects were dyslipidemia in 8 and infection in 2.19715864
deficiency aspectsDeregulated Nutrient SensingIt is characterized by insulin resistance in peripheral tissues and a relative deficiency in the pancreatic beta-cell functions.19716569
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDiverse single nucleotide polymorphisms (SNPs) of the IRS1 gene have been associated with insulin resistance and T2D risk.19716569
Microalbuminuria, Microvascular Angina, Liver CirrhosisDeregulated Nutrient SensingInsulin resistance and microalbuminuria are associated with microvascular disease in patients with cirrhosis.19718631
Fatty Liver Disease, Williams Syndrome, ObesityDeregulated Nutrient SensingCentral obesity and insulin resistance are common symptoms of both NASH and WS.19720629
Hyperlipidemia, Liver DysfunctionDeregulated Nutrient SensingLiver dysfunction, hyperlipidaemia, insulin resistance and regional increase of intra-abdominal fat even though the body mass indices were all normal or low, were observed.19720629
Weight decreasedDeregulated Nutrient SensingLow-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial.19720791
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow-fat hypocaloric diets reduce insulin resistance and prevent type 2 diabetes in those at risk.19720791
Weight decreasedDeregulated Nutrient SensingLow-carbohydrate, high-fat diets are advocated as an alternative, but reciprocal increases in dietary fat may have detrimental effects on insulin resistance and offset the benefits of weight reduction.19720791
Dyslipidemias, Coronary Arteriosclerosis, Diabetes MellitusDeregulated Nutrient SensingVRF sought were high blood pressure, dyslipidemia, diabetes mellitus, tobacco smoking, and atherosclerotic disease.19720973
Squamous cell carcinoma, Hepatitis C, SERPINB3 wt AlleleDeregulated Nutrient SensingWe investigated the association among oral squamous cell carcinoma (OSCC), multiple primary cancers (MPCs), insulin resistance and HCV infection.19721396
Primary malignant neoplasmDeregulated Nutrient SensingHistological evaluation of AMPK signalling in primary breast cancer.19723334
Primary malignant neoplasmDeregulated Nutrient SensingMalfunction of the AMPK pathway may allow cancer cells to undergo uncontrolled proliferation irrespective of their molecular energy levels.19723334
Primary malignant neoplasmDeregulated Nutrient SensingThe aim of this study was to examine the state of AMPK phosphorylation histologically in primary breast cancer in relation to clinical and pathological parameters.19723334
5-Trimethoxyamphetamine, Malignant neoplasm of breastDeregulated Nutrient SensingImmunohistochemistry was performed using antibodies to phospho-AMPK (pAMPK), phospho-Acetyl Co-A Carboxylase (pACC) an established target for AMPK, HER2, ERalpha, and Ki67 on Tissue Micro-Array (TMA) slides of two cohorts of 117 and 237 primary breast cancers.19723334
Primary malignant neoplasmDeregulated Nutrient SensingThis study extends in vitro evidence through immunohistochemistry to confirm that AMPK is dysfunctional in primary breast cancer.19723334
Neoplasm Metastasis, Breast CarcinomaDeregulated Nutrient SensingReduced signalling via the AMPK pathway, and the inverse relationship with histological grade and axillary node metastasis, suggests that AMPK re-activation could have therapeutic potential in breast cancer.19723334
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting of inadequate beta-cell compensation.19727413
Diabetes MellitusDeregulated Nutrient SensingResistin is a cytokine derived from adipose tissue and is implicated in obesity-related insulin resistance and type 2 diabetes mellitus.19727657
Dyslipidemias, ObesityDeregulated Nutrient SensingIn addition, plasma resistin level was associated with dyslipidaemia, serum insulin concentration and obesity.19727657
Adipose tissue loss, Dyslipidemias, Diabetes Mellitus, Lipodystrophy, DiseaseDeregulated Nutrient SensingLipodystrophy is a rare disorder characterised by loss of adipose tissue, hypoleptinaemia, severe insulin resistance, diabetes and dyslipidaemia.19727665
Lipodystrophy, DyslipidemiasDeregulated Nutrient SensingLeptin replacement in lipodystrophy patients leads to significant and sustained improvements in glycaemic control and dyslipidaemia.19727665
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImproving insulin resistance with traditional Chinese medicine in type 2 diabetic patients.19728183
Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingTCM can ameliorate insulin resistance in type 2 diabetes and it is safe and effective in newly diagnosed diabetic patients.19728183
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingUsefulness of statin-ezetimibe combination to reduce the care gap in dyslipidemia management in patients with a high risk of atherosclerotic disease.19733714
Primary malignant neoplasm, DyslipidemiasDeregulated Nutrient SensingThe PCI group was significantly associated with older age, dyslipidemia, history of cancer, high Euroscore, elevated creatininemia, single-vessel disease, fewer chronic occlusions of the left anterior descending artery, and more LMCA stenosis >or=70%.19735473
Hyperleucinemia, HyperglycemiaDeregulated Nutrient SensingBRO group presented hyperglycaemia (+16%, P < 0.05), lower muscle glycogen (51%, P < 0.05), higher cholesterol (+30%, P < 0.05), higher low-density lipoprotein (LDL-c) (+1.5 times, P < 0.05), higher triglycerides (+49%, P < 0.05), lower HDL-c (28%, P < 0.05), hyperleptinaemia (+2.9 times, P < 0.05), hypoadiponectinaemia (16%, P < 0.05) and hypoprolactinaemia (54%, P < 0.05) as well as higher insulin resistance index (+24%, P < 0.05).19736303
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes.19738363
ObesityDeregulated Nutrient SensingSIRT1 genetic variation is related to BMI and risk of obesity.19741164
ObesityDeregulated Nutrient SensingThe availability of SIRT1 stimulators makes these findings relevant in light of the growing obesity epidemic.19741164
Sleep-Disordered Breathing, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingSleep disordered breathing (SDB) has been associated with cardiovascular disease, hypertension, and insulin resistance.19743760
Sleep-Disordered BreathingDeregulated Nutrient SensingSDB was significantly correlated with insulin resistance (Spearman r correlation between AHI and HOMA=0.30, P<0.0001).19743760
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance is an independent additional risk factor for hypertension.19748246
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThe elevation of high-sensitivity C-reactive protein (hs-CRP) is a strong risk factor for cardio-vascular disease (CVD) and is associated with insulin resistance.19749491
Infection caused by Helicobacter pyloriDeregulated Nutrient SensingHelicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population.19751440
Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is the pathophysiologic background of the clinical features of atherosclerosis and cardiovascular diseases.19751440
Infection caused by Helicobacter pyloriDeregulated Nutrient SensingHelicobacter pylori infection significantly and independently contributed to promoting insulin resistance in a large asymptomatic population.19751440
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance and risk of incident hypertension among men.19751460
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance is independently associated with incident hypertension among younger men.19751460
Diabetes MellitusDeregulated Nutrient SensingDiets with a high postprandial glycaemic response may contribute to the long-term development of insulin resistance and diabetes; however, earlier epidemiological studies are conflicting on whether glycaemic index (GI) or glycaemic load (GL) are dietary factors associated with the progression.19756025
Dyslipidemias, Kidney Diseases, AtherosclerosisDeregulated Nutrient SensingDyslipidaemia does not only accelerate atherosclerosis in these patients but also progresses the renal disease.19764669
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAll factors that may lead to dyslipidaemia were excluded in all subjects except hypertension.19764669
DyslipidemiasDeregulated Nutrient SensingThe pattern of lipid profile did not change with severity of disease and dyslipidaemia in patients were more in triglycerides, 68.3% and HDL, 63.5% than in TC, 22.2% and LDL, 17.5%.19764669
Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia is common in pre-dialysis chronic kidney disease patients.19764669
Damage, DyslipidemiasDeregulated Nutrient SensingIt is pertinent to investigate and treat dyslipidaemia early in the course of the disease as it may prevent further progression of the renal damage.19764669
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients.19765773
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe aimed to determine whether insulin resistance or various biomarkers of cardiovascular risk have a role in the link between cystatin C and CVD in type 2 diabetes mellitus patients.19765773
Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, ObesityDeregulated Nutrient SensingRBP4 has been associated with insulin resistance and hypertriglyceridemia in obesity, the metabolic syndrome and type 2 diabetes.19765959
Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingAdjusting for CHD risk factors (smoking, diabetes, blood pressure, obesity and dyslipidemia) attenuated RRs.19766217
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4), a molecule secreted from adipocytes and hepatocytes, may contribute to insulin resistance and is a potential predictor for type 2 diabetes mellitus.19766271
Heart Diseases, InflammationDeregulated Nutrient SensingThis association does not appear to be mediated by co-morbid conditions, cardiac disease severity, insulin resistance, inflammation, neurohormones, or adipokines.19766751
Fatty LiverDeregulated Nutrient SensingGender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance.19773396
Fatty degenerationDeregulated Nutrient SensingSeverity of steatosis was associated with increased visceral fat mass, insulin resistance, lower adiponectin levels, and higher blood pressure.19773396
Fatty degenerationDeregulated Nutrient SensingRisk for steatosis hepatis with concomitantly elevated ALT was associated only with "insulin resistance and visceral fat" in girls and with all three factors in boys.19773396
Non-alcoholic Fatty Liver Disease, Obesity, VisceralDeregulated Nutrient SensingOur results suggest significant associations of NAFLD with markers of visceral obesity and insulin resistance in both genders and gender-specific associations with parameters of body fat distribution and sex steroids.19773396
Mitochondrial cardiomyopathy, Glucose Intolerance (disease)Deregulated Nutrient SensingPhysical and laboratory findings, including glucose intolerance and elevated serum lactate, suggested mitochondrial cardiomyopathy.19777318
DyslipidemiasDeregulated Nutrient SensingThey frequently had dyslipidaemia and both PPM groups received a biological valve more often than patients without PPM (94.1 and 77.1 vs. 19.1%, p<0.0001).19784883
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingComparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia.19785568
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingThe primary objective of this study was to demonstrate equivalence of pitavastatin compared with simvastatin in the reduction of low-density lipoprotein cholesterol (LDL-C) levels in patients with primary hypercholesterolaemia or combined dyslipidaemia.19785568
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingA prospective, randomised, active-controlled double-blind, double-dummy, 12-week therapy trial was conducted in 857 patients with either primary hypercholesterolaemia or combined dyslipidaemia.19785568
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingAs compared with simvastatin, an established first-line lipid-lowering agent, pitavastatin is an efficacious treatment choice in patients with primary hypercholesterolaemia or combined dyslipidaemia.19785568
Dyslipidemias, Overweight, diabeticDeregulated Nutrient SensingThe patients (4 males and 3 females, age 63 +/- 13 years) were either overweight (4) or obese (3); 57% were diabetic and 28.5% had dyslipidemia.19787150
Diabetes MellitusDeregulated Nutrient SensingThe association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women.19789205
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPatients newly treated with antihypertensives and with various levels of coronary heart disease (CHD) risk (including dyslipidemia, established CHD, type 2 diabetes mellitus, and no CHD but three or more cardiovascular risk factors) were included in the study.19791839
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe cumulative probability of being prescribed a statin increased with increasing numbers of CHD risk factors, irrespective of dyslipidemia status.19791839
Hypertensive (finding), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is associated with increased renal resistive index independent of other factors in newly diagnosed type 2 diabetes mellitus and hypertensive patients.19793596
Inflammation, EndotoxemiaDeregulated Nutrient SensingExperimental endotoxemia induces adipose inflammation and insulin resistance in humans.19794059
Diabetes Mellitus, Ventricular Dysfunction, Left, NEUROD1 wt AlleleDeregulated Nutrient SensingWhole body and myocardial insulin resistance are features of non-insulin-dependent diabetes mellitus (NIDDM) and left-ventricular dysfunction (LVD).19797329
NEUROD1 wt AlleleDeregulated Nutrient SensingOur data show that the mechanisms of myocardial insulin resistance are different between NIDDM and LVD.19797329
Inflammation, ObesityDeregulated Nutrient SensingRelationships among obesity, inflammation, and insulin resistance in African Americans and West Africans.19798069
Inflammation, ObesityDeregulated Nutrient SensingSeveral research studies in different populations indicate that inflammation may be the link between obesity and insulin resistance (IR).19798069
Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingSignificant predictors of plaque were male gender and age and, among women, dyslipidemia.19801304
ARCN1 gene, Dyslipidemias, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingComorbidities include: COPD 55.4%, coronary artery disease 60.9%, diabetes 44.6%, dyslipidemia 66.3% and dialysis 9.8%.19803257
Carotid Atherosclerosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigh fat stores in ectopic compartments in men with newly diagnosed type 2 diabetes: an anthropometric determinant of carotid atherosclerosis and insulin resistance.19806159
Low Density ArrayDeregulated Nutrient SensingOn the basis of multiple regression analyses, mid-thigh low-density muscle area and muscle attenuation were independently associated with the C-IMT, and the mid-thigh normal-density muscle area and muscle attenuation were independent factors of insulin resistance.19806159
Carotid AtherosclerosisDeregulated Nutrient SensingFurthermore, altered lipid partitioning within muscle was independently associated with carotid atherosclerosis and insulin resistance.19806159
ObesityDeregulated Nutrient SensingThe impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity.19808853
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction, AtherosclerosisDeregulated Nutrient SensingInsulin resistance, beta-cell dysfunction, and conversion to type 2 diabetes in a multiethnic population: the Insulin Resistance Atherosclerosis Study.19808919
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and beta-cell function are major predictors of type 2 diabetes, but studies using direct methods of insulin resistance and secretion are few and relatively small.19808919
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevention of type 2 diabetes should focus on interventions that improve both insulin resistance and insulin secretion.19808919
Hyperglycemia, Obesity, AbdominalDeregulated Nutrient SensingSpecific relation between abdominal obesity and early-phase hyperglycemia is modulated by hepatic insulin resistance in healthy older women.19808930
Obesity, AbdominalDeregulated Nutrient SensingTo describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women.19808930
Hyperglycemia, Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity relates specifically to early-phase hyperglycemia via hepatic insulin resistance, even in healthy older women.19808930
Chronic liver disease, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is strongly associated with insulin resistance.19813185
Myotonic Dystrophy, IGHD1-7 gene, Muscular DystrophyDeregulated Nutrient SensingMyotonic dystrophy (DM1) is the most common form of adult-onset muscular dystrophy, and there is a high frequency of insulin resistance due to insulin receptor mRNA splicing defects in muscle tissue.19813185
Non-alcoholic Fatty Liver Disease, IGHD1-7 geneDeregulated Nutrient SensingThirty-six patients with DM1 were prospectively assessed for the presence of NAFLD and insulin resistance.19813185
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese findings support the role of peripheral insulin resistance in the pathogenesis of NAFLD.19813185
diabeticDeregulated Nutrient SensingComparisons of diabetic potential, glucose related metabolic levels, and insulin resistance between olanzapine and risperidone have produced variable results in cross-sectional and epidemiologic studies.19814947
methionineDeregulated Nutrient SensingInsulin resistance was significantly attenuated in both groups, but to a lesser degree in the MET group (P = .045).19815243
Asthma, DyslipidemiasDeregulated Nutrient Sensingasthma and dyslipidaemia) than those reported by surveys, with certain age- and sex-related variations.19815673
Proteinuria, Steatohepatitis, Left ventricular massDeregulated Nutrient SensingOther insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, were also associated with IOP (P<0.0001, 0.002, and 0.01, respectively).19816514
Hypoadiponectinemia, Coronary Artery DiseaseDeregulated Nutrient SensingRelation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients.19818293
ObesityDeregulated Nutrient SensingImportantly, elevated levels of ADAM17 expression have been linked to obesity and insulin resistance.19819120
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, a risk factor for cardiovascular disease (CVD), is more prevalent in middle-aged women than in men of the same age in Korea.19819450
ObesityDeregulated Nutrient SensingAt the time of follow-up, AMS children exhibited 3-fold lower prevalence of severe obesity (11 vs. 35%, P = 0.004), greater insulin sensitivity (homeostasis model assessment of insulin resistance index 3.4 +/- 0.3 vs. 4.8 +/- 0.5, P = 0.02), improved lipid profile (cholesterol/high-density lipoprotein cholesterol 2.96 +/- 0.11 vs 3.40 +/- 0.18, P = 0.03; high-density lipoprotein cholesterol 1.50 +/- 0.05 vs. 1.35 +/- 0.05 mmol/liter, P = 0.04), lower C-reactive protein (0.88 +/- 0.17 vs. 2.00 +/- 0.34 microg/ml, P = 0.004), and leptin (11.5 +/- 1.5 vs.19.7 +/- 2.5 ng/ml, P = 0.005) and increased ghrelin (1.28 +/- 0.06 vs.1.03 +/- 0.06 ng/ml, P = 0.005) than BMS offspring (AMS vs. BMS, respectively, for all).19820018
Obesity, Abdominal, diabeticDeregulated Nutrient SensingThere was an age-associated increase in the prevalence of abdominal obesity and insulin resistance in elderly diabetic Japanese subjects, with a clear relationship between waist circumference and insulin resistance.19828932
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingFurthermore, abdominal obesity was strongly associated with dyslipidaemia and hypertension.19832855
square decimeter, Endothelial dysfunction, MS gene, ObesityDeregulated Nutrient SensingInsulin resistance (IR), present in patients with obesity, MS, and DM2, causes disturbances in the signaling pathways required for nitric oxide production, with subsequent endothelial dysfunction.19834133
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOur findings indicate that the control of hypertension and dyslipidemia among adult diabetics in the beginning of the decade was poor.19834341
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAge, diabetes family history, obesity, dyslipidemia and hypertension were all associated with the presence of diabetes in this study population.19836096
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingEpidemiological studies have established an association between dyslipidemias and atherosclerosis.19838489
Carcinogenesis, Metabolic Diseases, Pancreatic carcinomaDeregulated Nutrient SensingAlthough mounting evidence suggests that insulin resistance is involved in pancreatic carcinogenesis, few epidemiologic studies have comprehensively investigated the role of lifestyle factors influencing this metabolic disorder in the etiology of pancreatic cancer.19838917
Pancreatic carcinomaDeregulated Nutrient SensingOur study lends support to the hypothesis that dietary and other lifestyle factors influencing insulin resistance modulate pancreatic cancer risk.19838917
Chlamydia, Dyslipidemias, Atherosclerotic lesionDeregulated Nutrient SensingOur results imply the synergic contribution of Chlamydia pneumoniae DNA and known dyslipidaemia to the development of atherosclerotic lesions in patients undergoing CABG.19838954
insulinoma, Diabetes MellitusDeregulated Nutrient SensingThus, we hypothesised that characterisation of the islets in these mouse models at an early age should provide a unique opportunity to: (1) identify mechanisms involved in sensing insulin resistance at the level of the beta cells, (2) identify molecular effectors that contribute to increasing beta-cell mass and function, and (3) distinguish primary events from secondary events that are more likely to be present at more advanced stages of diabetes.19841237
Dyslipidemias, Malignant Neoplasms, Diabetes MellitusDeregulated Nutrient SensingDe novo diabetes (P < 0.07) or dyslipidemia (P < 0.01) as well as newly diagnosed malignancies (P < 0.059) were however more frequently observed in the Steroid maintenance group.19843296
DIAPH2 gene, Ovarian Failure, PrematureDeregulated Nutrient SensingIn mutant mice lacking the Tsc1 gene in oocytes, the entire pool of primordial follicles is activated prematurely due to elevated mTORC1 activity in the oocyte, ending up with follicular depletion in early adulthood and causing premature ovarian failure (POF).19843540
Tumor necrosis, ObesityDeregulated Nutrient SensingTumor necrosis factor alpha (TNFalpha) is a proinflammatory adipokine hypothesized to link obesity with insulin resistance.19846171
ObesityDeregulated Nutrient SensingWe tested the hypothesis that the association of measures of TNFalpha activity with insulin resistance is independent of obesity and adipose tissue biomarkers.19846171
Arterial Stiffness, Prediabetes syndrome, UremiaDeregulated Nutrient SensingIn conclusion, a high prevalence of pre-diabetes, impaired insulin resistance, increased arterial stiffness of aorta as well as impaired augmentation index and vasodilatation was demonstrated in uraemic patients prior to kidney transplantation.19846393
Cardiovascular DiseasesDeregulated Nutrient SensingEarly postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown.19846742
Hypertension, CTCAE, Stasis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo evaluate the effect of treatment for tonifying qi, nourishing yin, activating blood circulation and removing stasis on insulin resistance (IR) in patients of type 2 diabetes mellitus (T2DM) complicated with hypertension.19848209
Hepatobiliary DisorderDeregulated Nutrient Sensing[Fatty liver disease, insulin resistance and adiponectin in an obese pediatric population].19850541
Kidney NeoplasmDeregulated Nutrient SensingFinally, BHD inactivation led to both mTORC1 and mTORC2 activation in kidney tumors from BHD(d/+) mice and human BHD patients.19850877
FLCN protein, human, Renal carcinoma, Kidney NeoplasmDeregulated Nutrient SensingThese data support a role for PI3K-AKT pathway activation in kidney tumor formation caused by loss of BHD and suggest that inhibitors of both mTORC1 and mTORC2 may be effective as potential therapeutic agents for BHD-associated kidney cancer.19850877
Dyslipidemias, ObesityDeregulated Nutrient SensingFatty acid (FA) synthesis enzymes (FA synthase (FASN) and acetyl-CoA carboxylase (ACC)) are related to metabolic alterations such as obesity, insulin resistance, or dyslipidemia.19851294
Hyperglycemia, Hyperparathyroidism, Kidney FailureDeregulated Nutrient SensingRenal insufficiency predisposes to insulin resistance, hyperparathyroidism and derangements in calcium phosphate and nitrogenous compound balance, leading to pre-transplant hyperglycaemia.19854851
Bipolar DisorderDeregulated Nutrient SensingLeptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women.19855365
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAcceptable baked products can be prepared with added fenugreek, which will reduce insulin resistance and treat type 2 diabetes.19857068
Glucose Intolerance (disease)Deregulated Nutrient SensingThese results suggest that increased age, glucose intolerance, and irregular hours independently affect the intracellular clock in humans.19861640
deficiency aspects, Chronic disease, Diabetes MellitusDeregulated Nutrient SensingType-2 diabetes mellitus (T2DM) is a chronic disorder characterized by a varying range of predominant insulin resistance with relative insulin deficiency, to predominant insulin secretory defect with or without insulin resistance.19861867
Dyslipidemias, Cystic FibrosisDeregulated Nutrient SensingPrevalence of dyslipidemia in adults with cystic fibrosis.19875344
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia occurs in CF patients however no differences in lipid profiles were seen between those with diabetes and those without.19875344
DyslipidemiasDeregulated Nutrient SensingAs survival in CF increases, the prevalence of dyslipidemia may increase resulting in clinically important complications.19875344
diabeticDeregulated Nutrient SensingEffects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.19876588
Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingTo study the effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats, we first induced a model of type 2 diabetes in rats with a low-dose of streptozotocin.19876588
diabeticDeregulated Nutrient SensingAs a result, the apoptosis ratio of islet beta cells in diabetic rats was dramatically increased compared to the control group, and mRNA and protein expression of SIRT1 in islet beta cells were much lower than those of the control group.19876588
diabeticDeregulated Nutrient SensingThese data show that caloric restriction notably improves the sensitivity to insulin and significantly increases mRNA and protein expression of SIRT1 while decreasing the apoptosis ratio of islet beta cells in diabetic rats.19876588
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTherefore, SIRT1 may play an important role in the apoptosis of islet beta cells of type 2 diabetes.19876588
Dyslipidemias, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of dyslipidemia, hypertension, smoking, sedentariness, postmenopausal women, coronary artery disease (CAD) and familial history of CAD were determined.19876761
ETV3 wt AlleleDeregulated Nutrient SensingHaving multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (P for trend 0.002) and non-obese persons (P for trend 0.001) independent of insulin resistance.19878507
diabeticDeregulated Nutrient SensingIn a cohort of 169 type 2 diabetic subjects, plasma levels of APOH, antibodies anti-APOH, lipoprotein subfractions, oxidation, inflammatory and insulin resistance markers and the Trp316Ser and Val247Leu variations in the APOH gene were analyzed.19878946
ObesityDeregulated Nutrient SensingAccumulation of stressful life events was associated with insulin resistance, obesity, and triglycerides.19880581
AcromegalyDeregulated Nutrient SensingFinally, circulating OCN was the main determinant of insulin resistance and beta-cell function in acromegaly and in vitro, a blunted insulin response was observed in the presence of OCN and GH/IGF-I.19880791
Cardiac complication, Heat-Shock ResponseDeregulated Nutrient SensingSerum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study.19882236
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes MellitusDeregulated Nutrient SensingOxidative stress has been implicated in the pathogenesis of cardiovascular disease (CVD), diabetes and insulin resistance.19882236
Dyslipidemias, diabeticDeregulated Nutrient SensingDyslipidaemia and its management in diabetic patients in an academic centre in Iran.19885805
Dyslipidemias, diabeticDeregulated Nutrient SensingDyslipidaemia is accompanied with increased cardiovascular events in diabetic patients.19885805
Dyslipidemias, diabeticDeregulated Nutrient SensingAlthough recently we have made improvements in the control of dyslipidaemia in diabetic patients, we have not reached our goals.19885805
Dyslipidemias, diabeticDeregulated Nutrient SensingIn conclusion, we should revise our point of view to begin and intensify treatment of dyslipidaemia in diabetic patients, to achieve the goal of treatment and prevent cardiovascular events optimally.19885805
Weight Gain, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAntipsychotic medications are associated with significant weight gain, type 2 diabetes mellitus, dyslipidemia, and increased cardiovascular risk.19888560
Colorectal NeoplasmsDeregulated Nutrient SensingAssociation between adiponectin, resistin, insulin resistance, and colorectal tumors.19888587
Colorectal CarcinomaDeregulated Nutrient SensingIn this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance.19888587
Hypertensive (finding), Dyslipidemias, ObesityDeregulated Nutrient SensingParticipants were hypertensive patients taking ARBs for more than 8 weeks, and having dyslipidaemia, obesity or abnormal glucose metabolism.19888787
Proteinuria, Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIntensive treatment was a stepwise implementation of behavior modification, pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia, and proteinuria.19889469
Diabetes MellitusDeregulated Nutrient SensingPhysical activity was associated with a lower progression to diabetes in the total study population and in individuals with i-IGT, a condition primarily characterised by muscle insulin resistance.19898830
Diabetes MellitusDeregulated Nutrient SensingPhysical activity did not predict progression to diabetes in individuals with i-IFG, a condition primarily characterised by hepatic insulin resistance.19898830
diabeticDeregulated Nutrient SensingReduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors.19900156
diabetic, AtherosclerosisDeregulated Nutrient SensingM% and leg M% in diabetic patients were negatively correlated with the log-transformed triglyceride/high-density lipoprotein cholesterol (HDL-C) ratio, a marker of insulin resistance and atherosclerosis risk.19900156
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe highest risk was conferred by having the combination of risk factors of diabetes, hypertension, and dyslipidemia, with or without weight risk.19900158
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe combination of risk factors conferring the highest risk was diabetes, hypertension, and dyslipidemia.19900158
Hyperparathyroidism, PrimaryDeregulated Nutrient SensingInsulin resistance is not coupled with defective insulin secretion in primary hyperparathyroidism.19900227
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingSuccess rate was especially low among patients with IS compared with CAD: hypertension (23.8% v 27.2%; P = .028); dyslipidemia (13.6% v 20.3%; P < .001); and abdominal obesity (49.1% v 54.6%; P = .002).19900649
Endothelial dysfunctionDeregulated Nutrient SensingThe decreased endothelial VEGF expression and MVD found in patients with T2DM may be caused by insulin resistance and endothelial dysfunction, which are often present in patients with T2DM.19905947
Fatty degenerationDeregulated Nutrient SensingInsulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype.19905981
Fatty degeneration, HepatitisDeregulated Nutrient SensingModifications of oxidative stress are reported in hepatitis C. The relationship between insulin resistance (IR), steatosis and oxidative stress is not established.19905981
Mental disordersDeregulated Nutrient SensingWe studied 24 middle-aged and elderly patients with T2DM who were free of obvious vascular pathology or a psychiatric disorder, and 17 age- and education-matched healthy individuals with no evidence of insulin resistance.19906514
AHSG protein, human, Vascular calcificationDeregulated Nutrient SensingFetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance.19910501
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe development of Type 2 diabetes mellitus (T2DM) has been recognized to be associated with a combination of pancreatic beta-cell dysfunction and insulin resistance.19915388
Diabetes MellitusDeregulated Nutrient SensingFamily history of diabetes, exercise, insulin resistance, and leptin and ghrelin levels did not differ by parity group.19918009
Dyslipidemias, Lack of awareness findingDeregulated Nutrient SensingThe frequency of unawareness about these risk factors was respectively 8.4%, 17.5% and 33.1%.. Family history of CVD was reported by 41% while only 67% reported having any information about DM or dyslipidemia.19918665
Dyslipidemias, ObesityDeregulated Nutrient SensingThere was a significant association between obesity and dyslipidemia (p=0.04).19918665
Dyslipidemias, Obesity, AtherosclerosisDeregulated Nutrient SensingObesity and familial dyslipidemia in children are associated with accelerated atherosclerosis by pathological examination.19920030
Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingMetabolic factors such as obesity, hypertension, dyslipidemia and hyperglycemia have consistently been associated with increased risk of cardiovascular disease.19921129
DyslipidemiasDeregulated Nutrient SensingDyslipidemia increased from the 1970s to the 1980s but declined in the succeeding decade.19921129
Impaired cognitionDeregulated Nutrient SensingRecent studies have revealed the associations between insulin resistance (IR) and geriatric conditions such as frailty and cognitive impairment.19922671
Hypertension, CTCAE, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingIn Korea, the treatment of hypertension and dyslipidemia constitutes an important strategy for the prevention of cardiovascular disease (CVD).19922890
AtherosclerosisDeregulated Nutrient SensingHyperinsulinism was the most important factor associated to the occurrence of new cardiovascular events in Colombian patients with AMI, which emphasizes the pivotal role of insulin resistance in the physiopathologic mechanisms of atherosclerosis, especially in undeveloped countries.19923024
Glucose Intolerance (disease), Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingThe percentages of subjects with high blood pressure, glucose intolerance, dyslipidemia and hyperuricemia were 57.3, 12.7, 29.4 and 21.3%, respectively.19923679
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Chronic Obstructive Airway Disease, Hypertrophy, ObesityDeregulated Nutrient SensingThere were no significant sex differences in prevalence of obesity, dyslipidemia, history of chronic obstructive pulmonary disease/asthma, left ventricular (LV) hypertrophy, or history of myocardial infarction.19926005
DyslipidemiasDeregulated Nutrient SensingTreatment with rimonabant may improve adipokine levels in overweight/obese patients with dyslipidemia.19926622
Sleep-Disordered BreathingDeregulated Nutrient SensingAll these changes point to an inflammatory/insulin resistance state, suggesting that SDB in obese children share many similarities with SDB in obese adults.19926716
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia are highly prevalent in the elderly.19927131
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThese results document the importance of combined hypertension and dyslipidemia.19927131
Renal Insufficiency, Glucose Intolerance (disease)Deregulated Nutrient SensingLaboratory examination showed mild renal dysfunction and mild glucose intolerance.19928550
NeoplasmsDeregulated Nutrient SensingResveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.19928762
Breast CarcinomaDeregulated Nutrient SensingHere, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells.19928762
Primary malignant neoplasmDeregulated Nutrient SensingMoreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells.19928762
NeoplasmsDeregulated Nutrient SensingThese observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation.19928762
Primary malignant neoplasmDeregulated Nutrient SensingTargeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases.19928762
Primary malignant neoplasmDeregulated Nutrient SensingTo our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells.19928762
ETV3 wt AlleleDeregulated Nutrient SensingThe elevation of visfatin observed in children and adolescents with MetS was proportionate to number of components of MetS but was not associated with insulin resistance.19929281
Hypertensive (finding)Deregulated Nutrient SensingIrbesartan has no short-term effect on insulin resistance in hypertensive patients with additional cardiometabolic risk factors (i-RESPOND).19929980
White matter lesions, diabeticDeregulated Nutrient SensingAssociation between plasma high-sensitivity C-reactive protein and insulin resistance and white matter lesions in Japanese type 2 diabetic patients.19931932
diabeticDeregulated Nutrient SensingThis preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HSCRP and insulin resistance in type 2 diabetic patients not receiving insulin treatment.19931932
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results of this preliminary study indicate that the presence of WML was associated with the high HSCRP and insulin resistance in these Japanese patients with type 2 diabetes mellitus; larger cohort studies are warranted to confirm these findings.19931932
Dyslipidemias, ciliary vesicle, Hypertension, CTCAEDeregulated Nutrient SensingSubjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women).19933515
Dyslipidemias, Diabetes Mellitus, AtherosclerosisDeregulated Nutrient Sensingdiabetes alone increased the risk of atherosclerosis slightly in one affected system (OR 2.28, 95% CI 1.9-2.7) while combination of diabetes, smoking and dyslipidemia enhanced this risk (OR 7.4, 95% CI 2.5-22.4).19935590
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a well-established risk factor for cardiovascular diseases in the general population.19935998
Hyperglycemia, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both.19936237
Dyslipidemias, Overweight, Antihypertensive Agents, Diabetes MellitusDeregulated Nutrient SensingPrevalence of smoking was lower among hypertensives (adjusted prevalence ratio [APR] = 0.75; 95% CI: 0.64;0.89), whereas prevalence of overweight (APR = 1.37; 95% CI: 1.25;1.49), dyslipidemia (APR = 1.36; 95% CI: 1.26;1.36), and diabetes (APR = 1.37; 95% CI: 1.27;1.37) was higher.19936495
Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingThe presence of diabetes, systemic arterial hypertension and dyslipidemias, as well as the subject perceiving his/her health as regular or poor, were also reported by the interviewees with overweight or obesity.19936502
Gastroesophageal reflux disease, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIncidence and severity of hypertension, dyslipidemia, and GERD was comparable in both groups while diabetes was less common but more severe in the DS group (24.2% vs. 35.5%, Ali-Wolfe 3.27 vs. 2.94, p<0.05).19937190
Dyslipidemias, Weight decreased, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIn comparison to RYGB, DS provides superior resolution of diabetes, hypertension, and dyslipidemia in the super-obese independent of weight loss.19937190
Nonalcoholic Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Weight GainDeregulated Nutrient SensingNo recipient or donor factors were associated with disease recurrence, although patients with recurrent nonalcoholic steatohepatitis had a higher incidence of diabetes, weight gain, and dyslipidemia at the time of diagnosis of recurrence.19938117
ObesityDeregulated Nutrient SensingA better parameter in predicting insulin resistance: obesity plus elevated alanine aminotransferase.19938201
ObesityDeregulated Nutrient SensingObesity and elevated ALT are associated with insulin resistance.19938201
Sensorineural Hearing Loss (disorder), DyslipidemiasDeregulated Nutrient SensingThe role of dyslipidemia in sensorineural hearing loss in children.19939472
Sensorineural Hearing Loss (disorder), DyslipidemiasDeregulated Nutrient SensingWhen controlled for age and sex, no association between dyslipidemia and sensorineural hearing loss were found.19939472
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingConsumption of sugar-sweetened beverages (SSBs) was related to an elevated risk of type 2 diabetes and insulin resistance in several recent studies among middle- or older-aged populations.19940226
Dyslipidemias, OverweightDeregulated Nutrient SensingPrimary prevention of smoking, dyslipidemia and overweight should be more aggressively promoted in adolescence.19942306
DyslipidemiasDeregulated Nutrient SensingIncreased concentration of fibrinogen, dyslipidemia, and impaired fibrinolysis are regarded as important risk factors for CVD.19946236
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingBoth insulin resistance and increased oxidative stress in the liver are associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD).19946731
Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and dyslipidemia in behaviorally HIV-infected young women: Adolescent Trials Network study 021.19947855
Inflammation, Dyslipidemias, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity, dyslipidemia, and inflammation were prominent among HIV-infected adolescent women and, coupled with other risk factors, may accelerate the lifetime risk of cardiovascular disease and other adverse events.19947855
Dyslipidemias, Carotid Artery DiseasesDeregulated Nutrient SensingAnalysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.19951432
Dyslipidemias, Carotid Artery DiseasesDeregulated Nutrient SensingWe assessed the impact of 34 SNPs at 23 loci on dyslipidemia, key lipid sub-phenotypes, and severe carotid artery disease (CAAD) in a case-control cohort.19951432
DyslipidemiasDeregulated Nutrient SensingOur analysis of 34 SNPs contributing to dyslipidemia at 23 loci suggests that genetic variation in the 1p13.3 region may increase risk of CAAD by increasing LDL particle number, whereas variation in the 19q13.2 region may increase CAAD risk by promoting formation of smaller, denser LDL particles.19951432
Dyslipidemias, Ischemic stroke, diabeticDeregulated Nutrient SensingDyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital.19951571
Cerebrovascular Disorders, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidaemia is a potential independent risk factor for cerebrovascular disease in patients with diabetes.19951571
Dyslipidemias, Ischemic stroke, diabeticDeregulated Nutrient SensingThe aim of this study was to investigate dyslipidaemia, treatment and control of dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital.19951571
Dyslipidemias, diabetic, Cerebrovascular accidentDeregulated Nutrient SensingDiabetic patients suffering stroke displayed not only poorly-controlled lipid and lipoprotein profiles, including the significantly lower proportion of patients achieving intensified LDL-C target of < 2.07 mmol/L (80 mg/dl), and high density lipoprotein-cholesterol (HDL-C) target (14.4% vs 21.0%, P = 0.005; 45.8% vs 51.9%, P = 0.048 respectively), but also less adherence to therapy prescribed for dyslipidaemia (30.8% vs 41.0%, P = 0.001), when compared with diabetic patients without stroke.19951571
Dyslipidemias, diabetic, Cerebrovascular accidentDeregulated Nutrient SensingFor the diabetic women with stroke, situation of dyslipidaemia was worse, with significantly lower serum level of HDL-C and apoA1, higher LDL-C level and higher ratio of apoB/apoA1 when compared with diabetic counterparts without stroke.19951571
Dyslipidemias, Ischemic stroke, diabeticDeregulated Nutrient SensingMany diabetic patients with ischemic stroke remain uncontrolled for dyslipidaemia.19951571
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingApolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns.19952033
Dyslipidemias, ObesityDeregulated Nutrient SensingMeasures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia.19952033
Dyslipidemias, Endothelial dysfunction, Cardiovascular DiseasesDeregulated Nutrient SensingProtease inhibitors and other antiretroviral drugs have been associated with dyslipidemia, endothelial dysfunction, and increased cardiovascular disease risk.19952712
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOverall, the risk for type 2 diabetes or glucose intolerance (OR = 0.09, P = 0.022) and elevated blood pressure (OR = 0.46, P = 0.039) was decreased among the active cotwins.19952836
Sleep Apnea, Obstructive, Glucose Intolerance (disease), Sleep Apnea, CTCAE, Diabetes MellitusDeregulated Nutrient SensingCross-sectional studies have documented the co-occurrence of obstructive sleep apnea (hereafter, sleep apnea) with glucose intolerance, insulin resistance, and type 2 diabetes mellitus (hereafter, diabetes).19958890
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings suggest that nicotinamide overload, which induced an increase in plasma N(1)-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes.19960564
Glucose Intolerance (disease), Coronary heart diseaseDeregulated Nutrient Sensing[Effect of renshen jianxin capsule for alleviating insulin resistance in patients with coronary heart disease and glucose tolerance impairment].19960983
Glucose Intolerance (disease), Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo explore the effect of Renshen Jianxin Capsule (RJC) on insulin resistance in patients with coronary heart disease (CHD) and glucose tolerance impairment (GTI).19960983
Weight decreased, Osage languageDeregulated Nutrient SensingAt 6 months, weight loss and improvements in OSA were accompanied by improved insulin resistance (HOMA), increased HDL cholesterol, and reduced total cholesterol/HDL ratio.19961024
Sleep Apnea, CTCAE, HypoxemiaDeregulated Nutrient SensingImproved insulin resistance was partly associated with reductions in liver fat and hypoxemia associated with sleep apnea.19961024
Osage language, Dyslipidemias, Glucose Intolerance (disease), Obesity, Sleep Apnea, Obstructive, Hypertension, CTCAEDeregulated Nutrient SensingAlthough obstructive sleep apnea (OSA) is strongly linked with obesity, both conditions have been associated with increased cardiovascular risk including glucose intolerance, dyslipidemia, and hypertension independent of one another.19961024
Metabolic Syndrome XDeregulated Nutrient SensingIncreased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance.19961393
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance.19961393
MenopauseDeregulated Nutrient SensingMenopause is a process closely related to insulin resistance and cardiovascular risk factors.19962253
Hypotensive, DyslipidemiasDeregulated Nutrient SensingTherefore, in addition to the well documented hypotensive effects of Hibiscus sabdariffa, we suggest the use of HSEP in individuals with dyslipidemia associated with MeSy.19962289
DyslipidemiasDeregulated Nutrient SensingIn conclusion, current dyslipidemia therapy substantially improved LDL cholesterol goal attainment in this cohort, but low HDL cholesterol levels were unaffected.19962476
Increased insulin levelDeregulated Nutrient SensingWe investigated the contribution of the cholinergic nervous system to dexamethasone-induced insulin resistance and hyperinsulinemia in rats.19962776
Increased insulin levelDeregulated Nutrient SensingVagotomy per se did not affect insulin resistance, but attenuated fasted and fed insulinemia in VAG DEX, compared with SHAM DEX rats.19962776
SLC25A20 gene, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSeveral cross-sectional studies of general populations or high cardiovascular risk have shown that coronary calcium score (coronary artery calcium, CAC) was positively associated with traditional risk factors (hypertension, dyslipidemia, diabetes, and smoking) and some new risk factors (fibrinogen).19964672
Skeletal muscle structureDeregulated Nutrient SensingPPARgamma and PGC-1alpha mRNA expression in both fat depots as well as in skeletal muscle is associated with markers of insulin resistance and cardiovascular risk.19966034
Hyperlipidemia, InflammationDeregulated Nutrient SensingOur results indicate that improvement of insulin resistance, lipidemia, and blood pressure as well as reduction of systemic inflammation after bariatric surgery were associated with the increase of serum NO concentration.19997784
Carcinogenic Chlorinated Hydrocarbon, hepcidinDeregulated Nutrient SensingIn patients with CHC, serum hepcidin correlated positively with aspartate aminotransferase (r = 0.334, P = 0.001) and insulin resistance (r = 0.27, P = 0.016) and had a trend for correlation with alanine aminotransferase (r = 0.197, P = 0.057) and serum haemoglobin (r = 0.188, P = 0.067) but not with ferritin.20002304
Glucose Intolerance (disease), PolycythemiaDeregulated Nutrient SensingGlucose intolerance and activities of daily living were not directly associated with polycythemia after adjustment for sex.20002753
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingThe role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with chronic kidney disease: a randomised controlled trial.20003316
InflammationDeregulated Nutrient SensingWorryingly, recent observational data has highlighted an association between hypovitaminosis D and increased cardiovascular mortality, possibly mediated via vitamin D effects on insulin resistance and inflammation.20003316
Chronic Kidney DiseasesDeregulated Nutrient SensingThe main hypothesis of this study is that oral Vitamin D supplementation will ameliorate insulin resistance in patients with Chronic Kidney Disease stage 3 when compared to placebo.20003316
Chronic Kidney DiseasesDeregulated Nutrient SensingTo date, no randomised controlled trial has been performed in pre-dialysis CKD patients to study the correlation between vitamin D status with supplementation, insulin resistance and markers of adverse cardiovascular risk.20003316
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingAlcohol drinking in men with glucose intolerance was associated with a significant reduction in cardiovascular and all-heart disease mortality as seen in the general population in Japan.20004341
Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response TerminologyDeregulated Nutrient SensingThis preliminary study was therefore designed to test the hypothesis that DR is associated with insulin resistance and VFA in type 2 diabetes mellitus patients without insulin treatment.20004426
GDC Disease Response TerminologyDeregulated Nutrient SensingMultivariate logistic analysis revealed that DR was independently predicted by high VFA and insulin resistance.20004426
Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response TerminologyDeregulated Nutrient SensingThe results of this preliminary study indicate that the presence of DR was associated with high VFA and insulin resistance in Japanese patients with type 2 diabetes mellitus.20004426
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingA growing body of evidence strongly supports associations between reduced lung function and insulin resistance, type 2 diabetes mellitus, and cardiovascular disease.20006363
Renal Insufficiency, Dyslipidemias, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingThe growing population of elderly with chronic kidney disease (CKD) is at greater risk for cardiovascular disease given an independent risk of CKD, as well as from added dyslipidemia of aging and renal dysfunction.20006793
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTreatment of dyslipidemia in the general population suggests important benefits both in reducing cardiovascular risk and in the prevention of cardiovascular disease.20006793
Kidney Failure, Chronic, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingHowever, randomized trials have yet to confirm similar benefits and targets of treatment for dyslipidemia in the elderly with CKD and end-stage renal disease.20006793
Chronic Kidney Diseases, Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingThere is a need for further specific investigation of dyslipidemia of CKD in the aging population in relation to renal disease progression and cardiovascular outcome.20006793
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingRacial and ethnic differences in an estimated measure of insulin resistance among individuals with type 1 diabetes.20007942
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOBJECTIVE Insulin resistance is greater in racial/ethnic minorities than in non-Hispanic whites (NHWs) for those with and without type 2 diabetes.20007942
Diabetes Mellitus, Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingBecause previous research on insulin resistance in type 1 diabetes was limited to NHWs, racial/ethnic variation in an estimated measure of insulin resistance in type 1 diabetes was determined.20007942
Acanthosis Nigricans, ObesityDeregulated Nutrient SensingAge-adjusted eGDR was negatively associated with body fat, triglycerides, urinary albumin/creatinine, acanthosis nigricans, parental obesity, and parental insulin resistance and positively related to HDL and sex hormone-binding globulin.20007942
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingPatients with dyslipidemia and high overall risk of ischemic heart disease are those most likely to benefit from treatment with statins.20008151
HyperuricemiaDeregulated Nutrient SensingGenes responsible for insulin resistance could contribute to the development of hyperuricemia.20008926
HyperuricemiaDeregulated Nutrient SensingPrevious cross-sectional studies have suggested ADRB3 as a possible candidate gene in the development of hyperuricemia and insulin resistance.20008926
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLittle is known about how serum dioxins might affect insulin resistance, a hallmark of type 2 diabetes.20010210
ObesityDeregulated Nutrient SensingObesity, the most common cause of insulin resistance (IR), can be diagnosed by body mass index (BMI).20011958
Psoriasis, Dyslipidemias, Diabetes Mellitus, Depression, CTCAE, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingMultivariate models controlling for age, gender and consulting behaviour indicated that psoriasis is independently associated with depression (OR 1.49; 95% CI 1.20-1.86), stress-related disorders (OR 1.41; 95% CI 1.22-1.62), behaviour disorders (OR 1.58; 95% CI 1.05-2.39), diabetes (OR 1.21 95% CI 1.04-1.40), hypertension (OR 1.34; 95% CI 1.18-1.51), dyslipidaemia (OR 1.29; 95% CI 1.07-1.55), and obesity (OR 1.63; 95% CI 1.39-1.90).20015170
Inflammation, diabeticDeregulated Nutrient SensingIn type 2 diabetic individuals rosuvastatin was less effective than simvastatin at improving endothelium-dependent vasodilation within one month, without affecting insulin-resistance, adiponectin levels and inflammation.20018286
Obesity, Visceral, Diabetes MellitusDeregulated Nutrient SensingIncreased production of these proinflammatory molecules by VAT may explain the links observed between visceral obesity, insulin resistance, and diabetes risk.20019678
OverweightDeregulated Nutrient SensingTriglyceride to high-density lipoprotein cholesterol ratio (TG/HDL) >or=3.0 (in mg/dl) is a marker of insulin resistance in overweight persons.20019684
Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingLeptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease.20021311
Dyslipidemias, Anemia, HyponatremiaDeregulated Nutrient SensingDyslipidemia (73%), anemia (20%) and severe hyponatremia (13%) were found.20021371
ObesityDeregulated Nutrient SensingA low dietary intake of linoleic acid and elevated SCD-1 index may contribute to higher ALT activity in elderly men, even independently of obesity and insulin resistance.20022128
Hyperglycemia, Hyperuricemia, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight-obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR).20029511
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe percentages of patients with comorbidities were 33.8% diabetes (2.5% type 1), 69% dyslipidemia, and 93% hypertension.20030520
Atheroma, Diabetes MellitusDeregulated Nutrient SensingWe investigated expression of lipogenic genes in human and rat arterial walls, its regulation in cultured VSMC and determined if it is modified during insulin-resistance and diabetes, situations with increased risk for atheroma.20030821
Diabetes MellitusDeregulated Nutrient SensingDuring insulin-resistance and diabetes, this expression is not increased and resists to the actions of glucose and ADM.20030821
Atheroma, Diabetes MellitusDeregulated Nutrient SensingIt is unlikely that this metabolic pathway contribute to lipid accumulation of arterial wall during insulin-resistance and diabetes and thus to the increased risk of atheroma observed in these situations.20030821
Hypertension, CTCAE, Anemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAfter adjustment for age, sex, body mass index, smoking, hypertension, dyslipidemia, diabetes duration, hemoglobin A1c, medication use (hypoglycemic, anti-hypertensive, lipid-lowering and anti-platelet drugs) and kidney function measures, the association of anaemia with all-cause (adjusted HR 2.11, 1.32-3.35, p=0.002) and cardiovascular mortality (adjusted HR 2.23, 1.12-4.39, p=0.020) remained statistically significant.20031129
Alzheimers DiseaseDeregulated Nutrient SensingInsulin resistance and hippocampal volume in women at risk for Alzheimer's disease.20031276
Vascular Diseases, Cardiovascular Diseases, "Alzheimers Disease", Data types - Address, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD).20031276
Cardiovascular morbidityDeregulated Nutrient SensingWe hypothesized that this would also associate with metabolic phenotypes of insulin resistance and increased risk of cardiovascular morbidity and mortality.20031593
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingIn risk allele carriers, a defective response of USF1 to insulin results in the suboptimal response of relevant target genes that contributes to the enhanced risk of developing dyslipidemia and coronary heart disease.20031629
Shock, Myocardial Contraction, Dyslipidemias, Kidney FailureDeregulated Nutrient SensingIndependent predictors of increased risk of bleeding/VC in women included older age, shock, renal failure, presentation with non-ST-elevation myocardial infraction and larger sheath sizes, whereas the use of fluoroscopy-guided access, closure devices, history of dyslipidemia or prior PCI, and use of bivalirudin were protective.20031752
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingKnowledge of heart disease risk among SHIELD respondents with dyslipidemia.20031839
Heart Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRespondents in the US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) reported whether they had a diagnosis of dyslipidemia, were taking prescription dyslipidemia medication, and knew their heart disease risk (low, moderate, high, or do not know).20031839
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingOf 7629 respondents with dyslipidemia, 35% reported not taking cholesterol medication, and 29% reported not knowing their heart disease risk.20031839
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingA large proportion of respondents with dyslipidemia did not know their heart disease risk.20031839
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingThere is a gap in understanding and awareness of heart disease risk among respondents with dyslipidemia regardless of treatment status.20031839
Hashimoto Disease, DyslipidemiasDeregulated Nutrient SensingIn conclusion, the prevalence of dyslipidemia increases along with hypofunction of the thyroid and T4 replacement therapy may improve lipid profile in the cases of SH with Hashimoto thyroiditis.20032565
DyslipidemiasDeregulated Nutrient SensingThe most frequent dyslipidemia was low HDL-C followed by high triglycerides.20034514
Dyslipidemias, Coast And Southern Tsimshian language, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingOptimal BMI cut-offs for diabetes, hypertension, and dyslipidemia were much lower in Aborigines than the recommended WHO BMI cut-offs, while those in TSIs were around WHO BMI criteria.20034692
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOverall, 67% of patients were overweight or obese; obese and overweight patients were more likely to be female and have diabetes mellitus, hypertension, dyslipidemia, and less likely to be smokers.20034957
Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMultiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD.20036859
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no significant relationship between CMBs and the presence of diabetes mellitus and dyslipidemia.20037183
ETV3 wt AlleleDeregulated Nutrient SensingAfter adjusting for traditional cardiovascular risk factors and insulin resistance, the odds ratios [OR (95% CI)] of thicker IMT (> or =1.0 mm), higher PWV (> or =14.0 m/s) and low ABI (< or =1.0) for MetS were significantly increased [2.28 (1.19-4.38), 2.17 (1.36-3.46) and 1.72 (1.14-2.59), respectively, all P < 0.01] but were lower than the adjusted OR for those with three or more MetS components.20039893
ETV3 wt Allele, AtherosclerosisDeregulated Nutrient SensingMetS was associated with subclinical atherosclerosis independent of insulin resistance.20039893
deficiency aspects, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is associated with high blood glucose in the context of insulin resistance and relative insulin deficiency.20040363
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingIn 2007 and 2008, all cases had dyslipidaemia (LDL > 100 mg/dL) and were hypertensive.20043534
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingConcurrent diseases included hypertension, dyslipidemia and diabetes, respectively.20043561
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingDecreased NKCC1 activity in erythrocytes from African Americans with hypertension and dyslipidemia.20044742
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingNKCC1 activity is lower in erythrocytes of African Americans with essential hypertension and dyslipidemia than in Caucasian counterparts.20044742
Diabetes MellitusDeregulated Nutrient SensingIn addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus.20045536
Diabetes MellitusDeregulated Nutrient SensingVisfatin genotype may modify the insulin resistance and lipid profile in type 2 diabetes patients.20046156
Dyslipidemias, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus.20047560
Proteinuria, Dyslipidemias, Dysglycemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIndividuals were identified by Third Report of the National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP III) criteria (dysglycemia, hypertension, and dyslipidemia) and World Health Organization criteria (obesity and proteinuria).20047632
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMultivariate regression analysis showed that circulating sLR11 is independent contributing factor for the OCS, as well as diabetes mellitus and dyslipidemia.20047743
Perivascular Epithelioid Cell Neoplasms, NeoplasmsDeregulated Nutrient SensingClinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.20048174
NeoplasmsDeregulated Nutrient SensingTumors were assessed for immunohistochemical evidence of mTORC1 activation and genetic evidence of alterations in TSC1 and TSC2.20048174
Perivascular Epithelioid Cell NeoplasmsDeregulated Nutrient SensingPEComas demonstrated loss of TSC2 protein expression and evidence of baseline mTORC1 activation.20048174
Perivascular Epithelioid Cell Neoplasms, NeoplasmsDeregulated Nutrient SensingCONCLUSION Inhibition of mTORC1, pathologically activated by loss of the TSC1/TSC2 tumor suppressor complex, is a rational mechanistic target for therapy in PEComas.20048174
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes (T2D) is a metabolic disorder characterized by disturbances of carbohydrate, fat and protein metabolism and insulin resistance.20049090
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe majority of T2D patients are obese and obesity by itself may be a cause of insulin resistance.20049090
ObesityDeregulated Nutrient SensingVisceral adiposity is closely correlated with neck circumference and represents a significant indicator of insulin resistance in WHO grade III obesity.20050862
ObesityDeregulated Nutrient SensingVisceral adiposity remains a strongly significant indicator of insulin resistance in WHO grade III obesity.20050862
Diabetes MellitusDeregulated Nutrient SensingC358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2.20056290
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThis association was independent of other cardiovascular risk factors but dyslipidemia (p = 0.002) that was not represented in AMI patients with II genotype and in a lower extent with hypertension (p < 0.05).20059382
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThere are seven human sirtuins (SIRT1-7), and SIRT1 has been implicated as a key mediator of the pathways downstream of calorie restriction that have been shown to delay the onset and reduce the incidence of age-related diseases such as type 2 diabetes.20061378
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreasing SIRT1 activity, either by transgenic overexpression of the Sirt1 gene in mice or by pharmacological activation by small molecule activators resveratrol and SRT1720, has shown beneficial effects in rodent models of type 2 diabetes, indicating that SIRT1 may represent an attractive therapeutic target.20061378
Fat-free mass, Acromegaly, Somatotropin deficiencyDeregulated Nutrient SensingGH replacement decreased visceral adipose tissue, increased fat-free mass, decreased hsCRP, and improved quality of life in patients with GHD after cure of acromegaly, with minimal side effects and without an increase in insulin resistance.20061426
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingReduced serum levels of adiponectin have been associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD).20066503
AtherosclerosisDeregulated Nutrient SensingInsulin resistance and subclinical atherosclerosis are associated with SIRT1 downregulation in monocytes.20068143
Cholelithiasis, Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingCholelithiasis and fatty liver disease share some important risk factors, such as central obesity, insulin resistance, and diabetes.20068558
SteatohepatitisDeregulated Nutrient SensingConsistent with the hypothesis that DBC1 is crucial for HFD-induced inhibition of SIRT1 and for the development of experimental liver steatosis, genetic deletion of Dbc1 in mice led to increased SIRT1 activity in several tissues, including liver.20071779
SteatohepatitisDeregulated Nutrient SensingThese observations define what we believe to be a new role for DBC1 as an in vivo regulator of SIRT1 activity and liver steatosis.20071779
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDyslipidaemia and hypertension among adults with diabetes in rural Uganda.20075425
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDyslipidaemia and hypertension in patients with diabetes increase the risk of macrovascular and microvascular complications.20075425
Dyslipidemias, Diastolic hypertensionDeregulated Nutrient SensingThe prevalence of HDL and TG dyslipidaemia among the diabetics in Uganda is significantly higher than in non-diabetics, as is the prevalence of systolic and diastolic hypertension.20075425
ETV3 wt AlleleDeregulated Nutrient SensingThe common mechanism linking MetS components to CVD risk through small- and large-artery dysfunctions may be mediated through metabolic factors related to insulin resistance, not to increased BP.20075933
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingRisk factors for CAD were male gender, diabetes, dyslipidaemia and developing a cardiovascular condition disease during follow-up.20078615
Alzheimers DiseaseDeregulated Nutrient SensingThese data suggest that resveratrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.20080969
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe percentage of patients having two or three risk factors (such as dyslipidemia, hypertension, and DM) also increased with increased BMI.20081324
Pancreatic carcinomaDeregulated Nutrient SensingThis occurred despite a postoperative reduction in endocrine pancreas mass, which may suggest the presence of insulin resistance and diabetogenic effect of pancreatic cancer.20084568
Fibrosis, LiverDeregulated Nutrient SensingRisk factors for advanced liver fibrosis in HIV-infected individuals: role of antiretroviral drugs and insulin resistance.20088890
GTF2A1L wt Allele, Hepatitis C, Alcohol abuseDeregulated Nutrient SensingTherefore, in addition to chronic hepatitis C and alcohol abuse, insulin resistance and/or exposure to dideoxy-nucleosides may contribute to ALF in HIV-infected patients.20088890
Biliary calculi, Diabetes Mellitus, Non-Insulin-Dependent, Disease, Kidney CalculiDeregulated Nutrient SensingRecent evidence suggests that gallstones and kidney stones are associated with insulin resistance, but the relation between stone diseases and the risk of developing type 2 diabetes mellitus is not clear.20089496
Hyperuricemia, GoutDeregulated Nutrient SensingThe hyperuricemia in gout might be caused by the increased adiposity associated with insulin resistance.20091036
CarcinogenesisDeregulated Nutrient SensingThe increased risk for table sugar suggests that insulin resistance may play a role in pancreatic carcinogenesis.20091114
Prostate Cancer Outcomes Study, Endocrine System Diseases, Obesity, Hyperandrogenism, Anovulation, Polycystic Ovary SyndromeDeregulated Nutrient SensingThe polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity.20092643
Atherosclerosis of renal artery, AtherosclerosisDeregulated Nutrient SensingFood intake patterns associated with carotid artery atherosclerosis in the Insulin Resistance Atherosclerosis Study.20092665
Primary malignant neoplasmDeregulated Nutrient SensingInsulin resistance was associated with a 41% (95% confidence interval (CI) (1.07-1.87; p = 0.01) increased risk of overall cancer mortality.20094767
Hyperglycemia, Primary malignant neoplasmDeregulated Nutrient SensingIn conclusion, hyperglycemia and insulin resistance may be 'high-risk' conditions for cancer mortality.20094767
Microalbuminuria, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingCompared with those without microalbuminuria (n = 73), NAFLD patients with microalbuminuria (n = 14) had significantly higher homeostasis model assessment of insulin resistance values (3.9 +/- 1.3 vs 5.8 +/- 3.7, P < .001).20096896
Microalbuminuria, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese results indicate the presence of a significant association between the severity of insulin resistance and microalbuminuria in patients with NAFLD.20096896
Nijmegen Breakage SyndromeDeregulated Nutrient SensingBy epistasis-like analysis through knockdown and use of mutant cells of distinct SIRT1 target proteins, we show that the non-homologous end joining (NHEJ) factor Ku70 as well as the Nijmegen Breakage Syndrome protein (nibrin) are not needed for this SIRT1-mediated effect, even though a partial contribution of nibrin cannot be excluded.20097625
Primary malignant neoplasmDeregulated Nutrient SensingStrikingly however, the Werner helicase (WRN), which in its mutated form causes premature aging and cancer and which was linked to the Rad51-independent single-strand annealing (SSA) DSB repair pathway, is required for SIRT1-mediated HR.20097625
hearing impairment, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe found no evidence suggesting that our observed relationship between diabetes and hearing impairment is due to hypertension or dyslipidemia.20097782
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSeveral rare single nucleotide polymorphisms (SNP) have been linked to diseases accompanying insulin resistance such as Type 2 diabetes, obesity, and dyslipidemia in different populations.20101100
Hypertensive (finding), Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingPTP-1B polymorphisms contribute to pathogenesis of hypertension in Chinese subjects and PTP-1B SNP may be involved in the development of several features including dyslipidemia and obesity in hypertensive subjects.20101100
DyslipidemiasDeregulated Nutrient SensingComparing NF with SCS patients, a significantly higher percentage of dyslipidemia was found in the group of SCS patients (50 vs 23%, P=0.033).20103607
Glucose Intolerance (disease)Deregulated Nutrient SensingSubjects with glucose intolerance (i.e., IGT and T2DM) were older compared to subjects with NGT.20105040
TG gene, DyslipidemiasDeregulated Nutrient SensingAdults with dyslipidemia (non-HDL-C >130 mg/dL and triglycerides [TG] > or =150 but < or =500 mg/dL) were randomly assigned in a 1:1:1 ratio to receive the FDC, atorvastatin 40 mg, or fenofibrate 145 mg for 12 weeks.20110022
Hyperglycemia, Obesity, Visceral, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient Sensingthe clustering of visceral obesity, dyslipidemia, hyperglycemia, and hypertension, has become a major public-health challenge worldwide.20110915
physiopathologicalDeregulated Nutrient SensingAlthough insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified.20111010
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIn animal models, defects of the aP2 gene (aP2(-/-)) partially protected against the development of obesity-related insulin resistance, dyslipidemia, and atherosclerosis.20111020
Nonalcoholic Steatohepatitis, glycation, Dyslipidemias, Fatty Liver DiseaseDeregulated Nutrient SensingAtorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH.20112031
Dyslipidemias, Fatty Liver DiseaseDeregulated Nutrient SensingThis study included 43 patients with biopsy-proven NASH with dyslipidemia.20112031
Dyslipidemias, Fatty Liver DiseaseDeregulated Nutrient SensingThe present data demonstrated that atorvastatin decreased the serum levels of AGEs in NASH patients with dyslipidemia and suggest the usefulness of AGEs as a biomarker for the attenuation of NASH.20112031
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingPopulation mean total, low-density lipoprotein and high-density lipoprotein cholesterol (TC, LDL-C and HDL-C) and triglyceride (TG) concentrations, prevalence of dyslipidaemia, and treatment according to 2001 and 2005 Australian guideline target levels.20121678
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingCMRFCs included hypertension in addition to obesity, dyslipidemia, and diabetes.20122170
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAbout 1 in every 4 patients (25.3%) had diabetes, and 60.7% had dyslipidemia.20122170
Hypertensive (finding), Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAs compared to hypertensive patients without additional risk factors, adjusted odds ratios for BP control were significantly lower for all combinations of CMRFCs (ORs 0.15-0.83, all p < 0.04), with the exception of patients who had only dyslipidemia in addition to hypertension (OR = 1.09, p = NS).20122170
Dyslipidemias, Intestinal PolypsDeregulated Nutrient SensingA novel germline mutation in peroxisome proliferator-activated receptor gamma gene associated with large intestine polyp formation and dyslipidemia.20123124
Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingThe proband presented also dyslipidemia, hypertension and overweight, not associated to type 2 diabetes; of note, family members tested positive for the mutation and display only a dyslipidemic profile at variable penetrance with other biochemical parameters in the normal range.20123124
Adenocarcinoma, Dyslipidemias, Colonic PolypsDeregulated Nutrient SensingThis is the first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma.20123124
Noncommunicable Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia in newly diagnosed diabetes mellitus: the Jakarta primary non-communicable disease risk factors surveillance 2006.20124614
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia in subjects with newly diagnosed DM remains higher among all age groups than that in subjects without DM.20124614
Dyslipidemias, Demographics DomainDeregulated Nutrient Sensingthe prevalence of dyslipidemia among subjects with newly diagnosed DM is higher than that in subjects without DM.20124614
No metabolic abnormalities, Hypogonadism, Metabolic Syndrome XDeregulated Nutrient SensingIn this series of men with metabolic syndrome, hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities.20126854
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingAlterations in blood glucose levels indicating the presence of glucose intolerance were identified in 11.5% of the population while 9.3% displayed overt diabetes.20128154
Lupus Erythematosus, SystemicDeregulated Nutrient SensingType B insulin resistance syndrome with systemic lupus erythematosus.20129024
Unconscious State, HypoglycemiaDeregulated Nutrient SensingHe was admitted to the hospital because of unconsciousness and severe hypoglycemia in 2006, and was diagnosed as having Type B insulin resistance syndrome with the presence of insulin receptor antibody.20129024
ProteinuriaDeregulated Nutrient SensingEarly treatment with prednisolone might ameliorate proteinuria and insulin resistance.20129024
Lupus Erythematosus, Systemic, Lupus NephritisDeregulated Nutrient SensingWe experienced a rare case of Type B insulin resistance syndrome with increased activity of SLE, complicated with lupus nephritis.20129024
Hypoglycemia, Lupus Erythematosus, SystemicDeregulated Nutrient SensingIt appears that Type B insulin resistance syndrome should be suspected in differential diagnosis of hypoglycemia in SLE patients.20129024
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia and oxidative stress are causally related to atherogenesis and cardiovascular disease.20129371
Steatohepatitis, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingNo significant differences were observed with respect to sex, age, BMI, dyslipidemias, diabetes mellitus, arterial hypertension and hepatic steatosis.20129381
Hypertensive (finding)Deregulated Nutrient SensingAldosterone production is associated with insulin resistance in obese and hypertensive subjects.20130077
Autonomic neuropathy, diabeticDeregulated Nutrient SensingInsulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients.20130937
Hyperglycemia, Diabetic NeuropathiesDeregulated Nutrient SensingIn addition to chronic hyperglycemia, insulin resistance itself has been proposed to cause a diabetic neuropathy.20130937
Autonomic neuropathy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe evaluated the role of insulin resistance in the pathogenesis of peripheral and autonomic neuropathy in patients with type 2 diabetes.20130937
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEighty-six patients with type 2 diabetes were evaluated for the anthropometric and biochemical profiles, and Kitt value was calculated from insulin tolerance test to assess the insulin resistance.20130937
Hyperglycemia, Autonomic neuropathy, diabeticDeregulated Nutrient SensingInsulin resistance is independently associated with peripheral and autonomic neuropathy in Korean Type 2 diabetic patients along with hyperglycemia and HDL-cholesterol.20130937
Cessation of lifeDeregulated Nutrient SensingThe protein deacetylase SirT1 inhibits apoptosis in a variety of cell systems by distinct mechanisms, yet its role in chondrocyte death has not been explored.20131294
Tumor necrosisDeregulated Nutrient SensingExpression of SirT1 in chondrocytes led to increased chondrocyte survival in either the presence or the absence of tumor necrosis factor alpha/actinomycin D, while a reduction of SirT1 by siRNA led to increased chondrocyte apoptosis.20131294
Degenerative polyarthritisDeregulated Nutrient SensingExamination of cartilage from normal donors and OA patients revealed that PTP1B levels are elevated in OA cartilage in which SirT1 levels are decreased.20131294
Degenerative polyarthritisDeregulated Nutrient SensingFor the first time, it has been demonstrated that SirT1 is a mediator of human chondrocyte survival via down-regulation of PTP1B, a potent proapoptotic protein that is elevated in OA cartilage.20131294
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingIt has been reported that diabetes mellitus (DM) is associated with poor pulmonary function, which could be explained by insulin resistance.20132629
Microalbuminuria, Foot Ulcer, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingTo examine the association of biochemical markers of risk (plasma Hcy, microalbuminuria, lipoprotein (a)(Lp(a)) and diabetic dyslipidaemia) with the prevalence of diabetic foot ulceration in type 2 diabetic patients.20135633
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEfficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials.20136164
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMonotherapy with lipid-modifying medication is frequently insufficient to normalize lipid abnormalities in patients with mixed dyslipidemia and type 2 diabetes mellitus.20136164
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with mixed dyslipidemia and type 2 diabetes (n = 586).20136164
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFenofibric acid + statin combination therapy in patients with mixed dyslipidemia and type 2 diabetes was well tolerated and resulted in more comprehensive improvement in the lipid/apolipoprotein profile than either monotherapy.20136164
Hypertension, CTCAE, ras GTPase-Activating Proteins, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingGreater Green Triangle Diabetes Prevention Program: remaining treatment gaps in hypertension and dyslipidaemia.20136814
Polycystic Ovary SyndromeDeregulated Nutrient Sensing[Correlations between adipocytokines and insulin resistance in women with polycystic ovary syndrome].20137676
Polycystic Ovary SyndromeDeregulated Nutrient SensingTo investigate the correlations between adipocytokines and insulin resistance in women with polycystic ovary syndrome.20137676
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe higher levels of leptin and TNF-alpha, the lower level of adiponectin in obese PCOS and the higher level of TNF-alpha and IL-6 in non-obese PCOS suggested different adipocytokines play different roles of insulin resistance in PCOS.20137676
Dyslipidemias, Coronary Arteriosclerosis, Diabetes MellitusDeregulated Nutrient SensingWe think that colestimide therapy might provide a beneficial effect on atherosclerotic disease in diabetes mellitus with dyslipidemia through reduction of cholesterol and blood glucose.20139652
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingFurther studies in subjects with low serum 25(OH)D levels combined with impaired glucose tolerance, hypertension or dyslipidaemia are needed.20141565
Inflammation, DyslipidemiasDeregulated Nutrient SensingPotential mediators, including atherogenic dyslipidemia, insulin resistance, and inflammation, might underlie this association.20142527
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAtherogenic dyslipidemia, type 2 diabetes mellitus, and C-reactive protein level were potential mediators of this relation.20142527
ADIPOQ protein, human, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes.20142631
ADIPOQ protein, humanDeregulated Nutrient SensingThe adiponectin-leptin ratio correlated best with the clamp derived sensitivity index (r=0.553, p<0.001) compared to other surrogate measures of insulin resistance.20142631
ADIPOQ protein, human, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe adiponectin-leptin ratio is associated with insulin resistance, measured with the euglycemic hyperinsulinemic clamp, in Caucasians with T2D.20142631
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe adiponectin-leptin ratio promises to become a new laboratory marker of insulin resistance in T2D.20142631
Hypertension, CTCAE, PrehypertensionDeregulated Nutrient SensingInsulin resistance and prevalence of prehypertension and hypertension among community-dwelling persons.20145357
Hypertension, CTCAE, PrehypertensionDeregulated Nutrient SensingInsulin resistance was significantly associated with prehypertension as well as hypertension in the general population.20145357
Glucose Intolerance (disease), Cystic FibrosisDeregulated Nutrient SensingLow prevalence of glucose intolerance in racially mixed children with cystic fibrosis.20149123
Glucose Intolerance (disease)Deregulated Nutrient SensingAlthough not conclusive, these data suggest that in addition to age, the genotype:phenotype ratio may influence the development of glucose intolerance in patients with CF.20149123
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingPakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in the Punjab Province of Pakistan.20149776
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingOverall total glucose intolerance (diabetes and IGT) was present in 16.68% males and 19.37% females.20149776
Hypogonadism, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingTo investigate the effect of testosterone treatment on insulin resistance, glycemic control, and dyslipidemia in Asian Indian men with type 2 diabetes mellitus (T2DM) and hypogonadism.20150021
Non-alcoholic Fatty Liver Disease, Weight decreased, DyslipidemiasDeregulated Nutrient SensingOf these 25 subjects, 9 diagnosed as having nonalcoholic fatty liver disease (which is highly prevalent in obese individuals and strongly associated with dyslipidemia) underwent a weight loss program.20150556
Mucopolysaccharidosis IDeregulated Nutrient SensingRecently, a novel rehabilitation exercise method, low-intensity RE, combined with blood flow restriction (BFR), has been shown to stimulate mammalian target of rapamycin complex 1 (mTORC1) signaling and MPS in young men.20150565
Mucopolysaccharidosis IDeregulated Nutrient SensingWe hypothesized that low-intensity RE with BFR would be able to activate mTORC1 signaling and stimulate MPS in older men.20150565
Mucopolysaccharidosis IDeregulated Nutrient SensingWe measured MPS and mTORC1-associated signaling proteins in seven older men (age 70+/-2 yr) before and after exercise.20150565
Mucopolysaccharidosis IDeregulated Nutrient SensingWe conclude that low-intensity RE in combination with BFR enhances mTORC1 signaling and MPS in older men.20150565
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrevalence of dyslipidemia and, therefore, risk for cardiovascular diseases were high during the use of highly active antiretroviral therapy.20151093
TG gene, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was defined as TG >or=1.70 mmol/L or HDL-C 20156073
TG gene, Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingMen on antihypertensive medication had no increased risk of IHD mortality compared to untreated normotensive men, provided they were free from high TG and low HDL-C dyslipidemia.20156073
Hepatitis CDeregulated Nutrient SensingReduction of insulin resistance with effective clearance of hepatitis C infection: results from the HALT-C trial.20156586
Communicable Diseases, Hepatitis C, Diabetes MellitusDeregulated Nutrient SensingHepatitis C virus (HCV) infection is associated with an increased prevalence of diabetes and insulin resistance (IR); whether this is a causal relationship has not been established.20156586
Diabetes MellitusDeregulated Nutrient SensingLipotoxicity (increased tissue fat content) has been implicated in the development of muscle insulin resistance and type 2 diabetes mellitus (T2DM).20157197
cervical cancerDeregulated Nutrient SensingOncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells.20157519
cervical cancerDeregulated Nutrient SensingWe now present evidence that SIRT1, an aging-related NAD-dependent deacetylase, mediates HPV E7 survival function in SiHa cervical cancer cells.20157519
Weakness, Cachexia, Muscle (organ)Deregulated Nutrient SensingThe clinical consequences of bedrest may mimic those of cachexia, including rapid loss of muscle, insulin resistance, and weakness.20164314
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThus, this study aims to investigate if coffee use has any relationship with bright liver, measured by ultrasound bright liver score (BLS), in patients with non-alcoholic fatty liver disease (NAFLD), and which relationship, if any, is present with BMI and insulin resistance.20165979
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOdds ratios show that obesity, higher insulin resistance, lower HDL cholesterol, older age and arterial hypertension are associated with a greater risk of more severe BLS; to the contrary, coffee drinking is associated with less severe BLS.20165979
ObesityDeregulated Nutrient SensingCoffee use is inversely associated with the degree of bright liver, along with insulin resistance and obesity, which, to the contrary, are directly associated with greater likelihood and severity of bright liver appearance.20165979
Liver carcinoma, Non-alcoholic Fatty Liver Disease, Overweight, Liver CirrhosisDeregulated Nutrient SensingA possible opposite, if not antagonistic, role of coffee with regard to overweightness and insulin resistance, similar to that reported in hepatocarcinoma and cirrhosis, is envisaged in the natural history of NAFLD.20165979
Hypertension, CTCAEDeregulated Nutrient SensingThe pathophysiology underlying the association between hypertension and insulin resistance remains unclear.20167040
Hypertension, CTCAEDeregulated Nutrient SensingThese capillaroscopy data demonstrated an association with SBP but not insulin resistance, suggesting that capillary measures are unlikely to explain the association between hypertension and insulin resistance, at least with modest degrees of blood pressure elevation.20167040
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNormalization of glucose intolerance in first-degree relatives of patients with type 2 diabetes.20167387
Cessation of lifeDeregulated Nutrient SensingWe show that knockdown of endogenous DYRK1A and DYRK3 leads to hypophosphorylation of SIRT1, sensitizing cells to DNA damage-induced cell death.20167603
Inflammation, ObesityDeregulated Nutrient SensingTelomere length in relation to insulin resistance, inflammation and obesity among Arab youth.20178511
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area of Xinjiang.20178648
Hypertension, CTCAEDeregulated Nutrient SensingRole of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension.20179633
Hypertension, CTCAEDeregulated Nutrient SensingTo perform a two-stage study to explore the role of gene variants in the risk of insulin resistance and arterial hypertension.20179633
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingArteriosclerotic risk factors included age, hypertension, dyslipidemia, type 2 diabetes mellitus, and smoking.20180401
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe G1057D polymorphism in the insulin receptor substrate-2 (IRS-2) gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes.20184486
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingIn conclusion, patients with ALS show abnormal glucose tolerance that could be associated with increased FFA levels, a key determinant of insulin resistance.20184518
Osteoporosis, Cushing Syndrome, Dyslipidemias, Obesity, Saint Helena Islands, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Spinal FracturesDeregulated Nutrient SensingSubclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidaemia, central obesity, osteoporosis and vertebral fractures.20184600
Sleep Apnea, Obstructive, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObstructive sleep apnea is common in patients with type 2 diabetes, and its association with insulin and insulin resistance has been examined in cross-sectional studies.20185739
TriglyceridesDeregulated Nutrient SensingAfter accounting for adiposity, other risk factors were high insulin, insulin resistance, high triglycerides, and smoking, factors amenable to lifestyle intervention.20185739
Weight decreasedDeregulated Nutrient SensingBoth weight loss and ezetimibe plus weight loss significantly (all P < 0.05) reduced body weight, visceral and subcutaneous adipose tissues, insulin resistance and plasma triglycerides, VLDL-apoB-100, apoC-III, fetuin-A, and retinol-binding protein-4 and increased plasma adiponectin concentrations.20185740
Inflammation, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingNonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation.20185740
Depression, CTCAEDeregulated Nutrient SensingDepression and insulin resistance: cross-sectional associations in young adults.20185745
Depressive disorderDeregulated Nutrient SensingIn unadjusted models mean insulin resistance was 17.2% (95% CI 0.7-36.0%, P = 0.04) higher in men and 11.4% (1.5-22.0%, P = 0.02) higher in women with depressive disorder.20185745
Depressive disorderDeregulated Nutrient SensingAfter adjustment for behavioral and dietary factors, the increased level of insulin resistance associated with depressive disorder was 13.2% (-3.1 to 32.3%, P = 0.12) in men and 6.1% (-4.1 to 17.4%, P = 0.25) in women.20185745
Depressive disorderDeregulated Nutrient SensingA positive association was found between depressive disorder and insulin resistance in this population-based sample of young adult men and women.20185745
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingOlder age and the presence of diabetes, hypertension and dyslipidaemia were significantly associated with CKD in all ethnic groups.20185856
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingDiabetes (45%) and dyslipidaemia (16%) among Malays and hypertension among Indians (23%) had greater population-attributable risk of CKD.20185856
Obesity, Dyslipidemias, Hypertension, CTCAE, HypothyroidismDeregulated Nutrient SensingOf the patients, 400 (40%) were diagnosed with dyslipidemia and hypertension (p = 0.002), 160 (16%) with obesity and 80 (8%) with hypothyroidism.20186515
ObesityDeregulated Nutrient SensingThe mechanism is unclear, and central (visceral) obesity, insulin resistance, altered sex steroids and altered adipokines are mooted as possible factors.20189371
Lupus ErythematosusDeregulated Nutrient SensingType B insulin resistance complicated with systemic lupus erythematosus.20190490
DiseaseDeregulated Nutrient SensingThis is a rare and important case report showing a clear correlation between anti-insulin receptor autoantibodies of type B insulin resistance and SLE disease activity.20190490
Discordance, Hypercholesterolemia, Dyslipidemias, diabeticDeregulated Nutrient SensingHypercholesterolemia was a predominant expression of dyslipidemia in discordance with literature dates for diabetic patient.20191816
Prediabetes syndromeDeregulated Nutrient SensingRecent data suggest that clearance of UA is being reduced with increase in insulin resistance and UA as a marker of prediabetes period.20192932
DyslipidemiasDeregulated Nutrient SensingThe main risk factors of T2DM chronic complications seemed to be related to high CRP, dyslipidemia, high BUN and high LDL-C.20193318
AtherosclerosisDeregulated Nutrient SensingAdipocyte fatty acid-binding protein (A-FABP) has been shown to have an effect on insulin resistance, lipid metabolism, and atherosclerosis in animals.20193950
Hypertensive (finding)Deregulated Nutrient SensingDietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance.20195917
Hypertensive (finding)Deregulated Nutrient SensingForty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the study.20195917
Hypertensive (finding)Deregulated Nutrient SensingThe obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper, zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance.20195917
Electrocardiogram: myocardial infarction (finding), DyslipidemiasDeregulated Nutrient SensingDyslipidemia is an important risk factor for myocardial infarction (MI).20198310
21-hydroxylase deficiencyDeregulated Nutrient SensingFunctional laboratory tests ruled out heterozygous C21-hydroxylase deficiency and showed a moderate insulin resistance on the oral glucose tolerance test.20198556
AHSG protein, human, Diabetes MellitusDeregulated Nutrient SensingFetuin-A is a liver-derived factor that may play a role in insulin resistance and age-related chronic diseases (eg, type 2 diabetes mellitus and cardiovascular [CV] disease).20199782
InflammationDeregulated Nutrient SensingIn addition to their expected effects on lipid profile, lipid-lowering agents may reduce cardiovascular events because of effects on nonclassic risk factors such as insulin resistance and inflammation.20199786
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe relationship of CVD to population variation in dyslipidemia and body composition needs further study, particularly in populations where the burden of cardiovascular and metabolic disease is rapidly increasing.20199988
diabeticDeregulated Nutrient SensingWhen corrected for alterations in insulin resistance, the change in insulin secretion remained significant only in the obese-type 2 diabetic group (1.23 +/- 0.26 vs. 2.04 +/- 0.46 arbitrary units; P < 0.01).20200305
Endothelial dysfunction, Diabetes MellitusDeregulated Nutrient SensingEndothelial dysfunction is frequently present in individuals with insulin resistance or type 2 diabetes and can be induced by high-fat or high-carbohydrate meals.20200309
Diabetes MellitusDeregulated Nutrient SensingG1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2.20204253
Weight decreasedDeregulated Nutrient SensingIn the weight loss study, the increase in circulating osteocalcin concentration (+70.6 +- 29.3 vs. +32 +- 13.5%, p = 0.021) was significantly greater in subjects with the highest decrease in ALT levels, despite similar baseline BMI, insulin resistance and degree of weight loss than remaining subjects.20204603
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance in subjects not previously diagnosed with diabetes was categorized according to 2003 American Diabetes Association criteria.20206389
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrevious studies have reported that statin use was associated with reductions in cardiovascular morbidity and mortality among patients with dyslipidemia, even without established cardiovascular disease.20206788
Degenerative polyarthritis, Osteoporosis, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe most frequent were systemic arterial hypertension (56.7%), osteoporosis (23.3%), osteoarthritis (21.2%) and dyslipidemia (20%).20209343
Impaired cognition, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Overweight, Cardiac ArrhythmiaDeregulated Nutrient SensingWe found correlation between some risk factors and cognitive impairment / depression (hypertension, overweight, dyslipidemia, diabetes, arrhythmia, carotid system lesion).20209767
Microalbuminuria, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingKidney function [estimated glomerular filtration rate (e-GFR) by two well-established equations and creatinine clearance], HDL-C, triglycerides, apoA-I and insulin resistance (HOMAir) were measured in 2,484 fasting subjects (e-GFR>or=45 ml/min/1.73 m2) without macroalbuminuria, cardiovascular disease, diabetes, or the use of anti-hypertensives and/or lipid-lowering agents.20211930
GoutDeregulated Nutrient Sensing[Effects of serial gout granules on insulin-resistance in primary gout patients].20214324
Primary gout, GoutDeregulated Nutrient SensingTo clarify the correlation between primary gout and insulin-resistance (IR), and to observe the effect of serial gout granules (SGGs) on IR in patients with primary gout.20214324
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingOne of the factors involved in type 2 diabetes in males is a reduction in levels of testosterone, which has been shown to predict resistance to insulin and the development of cardiovascular diseases.20214724
Primary malignant neoplasm, Cachexia, AnorexiaDeregulated Nutrient SensingAnorexia, cachexia, and insulin resistance are commonly seen in patients with cancer.20215915
Weight decreased, CachexiaDeregulated Nutrient SensingThe objective of this study was to determine the levels of adipokines and their relation to appetite, weight loss, insulin resistance, and other hormones in cancer cachexia.20215915
Primary malignant neoplasm, CachexiaDeregulated Nutrient SensingLeptin levels were significantly decreased in cancer cachexia and were directly associated with appetite and insulin resistance, explaining 37% and 19% of the variance seen in cancer patients, respectively.20215915
Primary malignant neoplasmDeregulated Nutrient SensingLeptin may play a role in the increased insulin resistance seen in cancer patients.20215915
Arterial StiffnessDeregulated Nutrient SensingInsulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women.20215975
Arterial Stiffness, Cardiovascular Diseases, AtherosclerosisDeregulated Nutrient SensingCardiovascular disease risk increases after menopause, which may be related to insulin resistance, and arterial stiffness is a significant predictor of atherosclerosis.20215975
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of hypertension, dyslipidaemia and diabetes was 17.3%, 66.3% and 5.6% respectively.20218138
leukemiaDeregulated Nutrient SensingMoreover, we found that blockade of mTORC1 by RAD001 synergistically enhanced the action of AZD6244 in leukemia cells.20221697
Ischemic stroke, White matter lesionsDeregulated Nutrient SensingCorrelation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke.20223079
Cerebral white matter lesions, Ischemic strokeDeregulated Nutrient SensingWe investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke.20223079
Ischemic stroke, White matter lesionsDeregulated Nutrient SensingIt was found that insulin resistance correlated with white matter lesions among non-diabetic patients with non-cardiogenic ischemic stroke.20223079
InflammationDeregulated Nutrient SensingThese findings suggest that serum biomarkers of insulin resistance and inflammation may be predictive of clinical outcomes following LEB.20223619
InflammationDeregulated Nutrient SensingImproving the systemic milieu of insulin resistance and inflammation in these high-risk patients may lead to reduced morbidity and mortality.20223619
Inflammation, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingSince atherosclerosis is a multifactorial disease, the aim of this study was to determine association between hsCRP and other markers of inflammation and dyslipidemia.20225663
ReducedDeregulated Nutrient SensingThey confirm that treatment of insulin resistance decreases T production in this population and demonstrate that pharmacologic lowering of T does not affect insulin resistance.20226444
Dyslipidemias, ObesityDeregulated Nutrient SensingThe characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population.20233452
Diabetes MellitusDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4) has been reported to be involved in the development of insulin resistance and diabetes.20233518
Metabolic Syndrome XDeregulated Nutrient SensingMetabolic syndrome is a well-known cardiovascular risk factor closely related to increased insulin resistance.20233530
Dyslipidemias, ObesityDeregulated Nutrient SensingCigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI.20235218
Diabetic Nephropathy, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia may be a risk factor for diabetic kidney disease.20236720
HypercholesterolemiaDeregulated Nutrient SensingAtorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients.20298928
HypercholesterolemiaDeregulated Nutrient SensingDespite beneficial reductions in LDL cholesterol and apolipoprotein B, atorvastatin treatment resulted in significant increases in fasting insulin and glycated hemoglobin levels consistent with insulin resistance and increased ambient glycemia in hypercholesterolemic patients.20298928
Gall Bladder Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Chronic disease, Hypertension, CTCAEDeregulated Nutrient SensingObesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease.20301983
Malignant NeoplasmsDeregulated Nutrient SensingInsulin resistance and lower plasma adiponectin increase malignancy risk in nondiabetic continuous ambulatory peritoneal dialysis patients.20303125
palladium, Malignant NeoplasmsDeregulated Nutrient SensingThese findings demonstrate that insulin resistance and lower adiponectin levels could be risk factors for malignancy in nondiabetic PD patients.20303125
Decreased LDL cholesterol concentrationDeregulated Nutrient SensingDissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia.20303351
SteatohepatitisDeregulated Nutrient SensingHepatic steatosis is associated with insulin resistance, but it is not clear whether increased intrahepatic triglyceride (IHTG) content causes the resistance or is a marker.20303351
Familial hypobetalipoproteinemia, Fatty degeneration, physiopathologicalDeregulated Nutrient SensingSteatosis is dissociated from insulin resistance in FHBL, which suggests that increased IHTG content is a marker, not a cause, of metabolic dysfunction.20303351
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingEffects of omega-3 polyunsaturated fatty-acid supplementation on redox status in chronic renal failure patients with dyslipidemia.20303788
Cancer-related fatigue, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingWe sought to evaluate the effects of omega-3 polyunsaturated fatty-acid (PUFA) supplementation on dyslipidemia, lipid and protein peroxidation, and antioxidant defense in patients with chronic renal failure (CRF).20303788
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThey presented with dyslipidemia and hypertriglyceridemia (triacylglycerols, >1.7 mmol/L) and/or hypercholesterolemia (total cholesterol, >5 mmol/L).20303788
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingThe prevalence of insulin resistance and cardiovascular disease (CVD) increases with degree of obesity.20304617
No metabolic abnormalitiesDeregulated Nutrient SensingBMI is at least comparable to WC in stratifying individuals for prevalence of metabolic abnormalities associated with increased CVD risk and predicting insulin resistance.20304617
Diabetes MellitusDeregulated Nutrient SensingInfluence of Ala54Thr polymorphism of fatty acid-binding protein 2 on insulin resistance and adipocytokines in patients with diabetes mellitus type 2.20329566
Diabetes MellitusDeregulated Nutrient SensingThis polymorphism could be associated with insulin resistance and adipocytokines in patients with diabetes mellitus type 2.20329566
Diabetes MellitusDeregulated Nutrient SensingThe aim of our study was to investigate the influence of Thr54 polymorphism in the FABP2 gene on adipocytokines and insulin resistance in the fasted state in naive patients with diabetes mellitus type 2.20329566
Glucose Intolerance (disease)Deregulated Nutrient SensingIn men, 25-OH-D levels were lower in those with glucose intolerance than normoglycemia (P = 0.01).20332348
ObesityDeregulated Nutrient SensingGenetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity.20335544
ObesityDeregulated Nutrient SensingReplication of our findings and further in-depth studies of dietary patterns that modify SIRT1 may lead to clinical studies of dietary modification of SIRT1 to influence obesity.20335544
Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingHypertension was present as a preoperative risk factor in most patients (74.2%); dyslipidemia was present in 51.6%, diabetes mellitus in 38.7%, stroke in 73%, and renal failure in 2.4%.20336998
Diabetes MellitusDeregulated Nutrient SensingAs for glucose and lipid metabolism, homeostasis model assessment insulin resistance (HOMA-R) level in the non-diabetic group and triglyceride in the diabetes group were significantly lower with cilnidipine than with amlodipine.20337636
Dyslipidemias, Demographics Domain, HPT gene, GDC Disease Response TerminologyDeregulated Nutrient SensingDuration of DM, HPT and presence of DN were associated with DR. HPT and dyslipidemia were associated with DN.20339790
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingHIV infection is associated with dyslipidaemia, and becomes increasingly debilitating as immunodeficiency progresses.20345886
Rheumatoid Arthritis, Obesity, AbdominalDeregulated Nutrient SensingVisfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in women with rheumatoid arthritis.20346233
Obesity, Abdominal, Refractory anemias, Rheumatoid Arthritis, Obesity, OverweightDeregulated Nutrient SensingThe increasing incidence of overweight and obesity in modern societies, and the demonstration that adipose tissue produces numerous cytokines, increases interest of investigators in the associations between adipose tissue, adipokines, CRP and insulin resistance in rheumatoid arthritis (RA) and their possible role in the pathogenesis of this disease.The purpose of the study was to investigate serum levels of visfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in patients with RA.20346233
Refractory anemiasDeregulated Nutrient SensingVisfatin as well as resistin did not correlate with anthropometric parameters or insulin resistance in whole patients with RA.20346233
ProteinuriaDeregulated Nutrient SensingAfter the study, ADMA, sFas, myostatin, insulin resistance, high-sensitive C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), blood pressure and proteinuria levels were decreased, and FMD and serum albumin levels increased (P < 0.05 for all).20348148
Cardiovascular Diseases, Refractory anemias, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Rheumatoid ArthritisDeregulated Nutrient SensingTo determine the proportion of rheumatoid arthritis (RA) patients receiving preventive health care according to US Preventive Services Task Force recommendations compared with a community-based population sample, with emphasis on dyslipidemia testing, given the increased risk of cardiovascular disease (CVD) in RA patients.20349066
Refractory anemias, Dyslipidemias, OsteoporosisDeregulated Nutrient SensingPatients with RA were more likely to have had dyslipidemia and osteoporosis testing compared with the general population (86 vs. 75 and 75 vs. 55%, respectively, P < 0.0001 for both).20349066
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThe RA patients with traditional cardiovascular risk factors are more likely to be tested for dyslipidemia.20349066
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA prospective trial of U500 insulin delivered by Omnipod in patients with type 2 diabetes mellitus and severe insulin resistance.20350913
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo test the effectiveness and safety of U500 regular insulin delivered by continuous subcutaneous insulin infusion (CSII) via the Omnipod insulin delivery system in patients with uncontrolled type 2 diabetes mellitus and severe insulin resistance.20350913
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn CRI groups, patients were older and had a higher prevalence of hypertension, diabetes mellitus, and dyslipidemia.20360292
Dyslipidemias, Diabetes Mellitus, Degenerative polyarthritis, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIndeed, OA has been linked not only to obesity but also to other cardiovascular risk factors, namely, diabetes, dyslipidemia, hypertension, and insulin resistance.20367223
Dyslipidemias, Psoriasis, ObesityDeregulated Nutrient SensingPatients with psoriasis have reported to have cardiometabolic disturbances including obesity, insulin resistance, and dyslipidemia.20367239
Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is significantly associated with coronary artery disease and cardiovascular events in patients with or without type 2 diabetes mellitus.20368081
Inflammation, AtherosclerosisDeregulated Nutrient SensingThe chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic inflammation, insulin resistance and atherosclerosis.20368224
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis observation strongly supports the implication of the PPARG Pro12Ala in insulin resistance and T2D in a Russian population.20368233
Hypertensive (finding), Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe authors analyse effect of GPIIIA gene (PI a allele) polymorphism on the frequency of complicated coronary heart disease in patients with dyslipidemia and hypertensive disease.20369606
Primary malignant neoplasmDeregulated Nutrient SensingSIRT1 which has a role in ageing and cancer and is known to regulate p53 signaling through acetylation.20370686
Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Fatty degenerationDeregulated Nutrient SensingInsulin resistance was significantly associated with steatosis, fibrosis, hepatocellular ballooning, NAS, and NAFLD pattern.20372110
Non-alcoholic Fatty Liver Disease, ETV3 wt Allele, ObesityDeregulated Nutrient SensingIndividual MetS features, particularly central obesity and insulin resistance, were also associated with severity of NAFLD.20372110
Disease of capillaries, diabeticDeregulated Nutrient SensingInsulin resistance is associated with microangiopathy in type 1 diabetic patients treated with intensive insulin therapy from the onset of disease.20373280
HyperphagiaDeregulated Nutrient SensingForced expression of wild-type Sirt1 in the mediobasal hypothalamus by adenovirus microinjection suppressed Foxo1-induced hyperphagia, a model for central insulin resistance.20375183
Diabetes MellitusDeregulated Nutrient SensingPharmacological activators of Sirt1 have been reported to increase the life span and improve the health of mice fed a high-fat diet and to reverse diabetes in rodents.20375183
Hypertensive (finding)Deregulated Nutrient SensingAssociation of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients.20376890
Hypertensive (finding)Deregulated Nutrient SensingThe aim of this study was to determine whether retinol-binding protein 4 (RBP4), adiponectin and high molecular weight (HMW) adiponectin are associated with insulin resistance (IR) and metabolic parameters in non-diabetic hypertensive patients.20376890
MalnutritionDeregulated Nutrient SensingRelationship of insulin resistance in chronic haemodialysis patients with inflammatory indicators, malnutrition, echocardiographic parameters and 24 hour ambulatory blood pressure monitoring.20377496
Fluid overload, Chronic Kidney DiseasesDeregulated Nutrient SensingThe decrease in ISI-S along with the hypervolaemia suggests that volume overload is a contributory factor in the pathogenesis of insulin resistance in patients with chronic renal failure.20377496
Fluid overloadDeregulated Nutrient SensingThis study indicates that, in addition to the traditional cardiovascular risk factors in these patients, insulin resistance can be regarded as a risk factor, but not an independent one, mainly a reflection of the underlying culprit, hypervolaemia.20377496
Inflammation, Dyslipidemias, PEELING SKIN SYNDROMEDeregulated Nutrient SensingThe presence of dyslipidemia in pSS was associated with increased ESR (44.05+/-28.07 versus 28.28+/-18.00, P=0.03), but not with other laboratory markers of the disease and inflammation.20378384
Kidney Failure, Chronic, DyslipidemiasDeregulated Nutrient SensingIn summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis.20378825
Feeding behaviorsDeregulated Nutrient SensingThus, insulin resistance in CP patients seems to affect eating behavior by affecting meal responses of gut peptides.20379145
Malnutrition, DyslipidemiasDeregulated Nutrient SensingSerum beta(2)-microglobulin was associated with longer duration on hemodialysis, malnutrition inflammation (lower serum albumin and higher high-sensitivity C-reactive protein) and dyslipidemia.20379193
Dyslipidemias, Chronic disease, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAs many as 78.6% used medications and 82.1% admitted to suffering from some non-transmissible chronic disease, the most frequent being hypertension (56.4%), dyslipidaemia (33.3%) and diabetes mellitus (20.5%).20379660
Diabetes MellitusDeregulated Nutrient SensingThese results indicate that in addition to involvement in insulin resistance, impaired function of mesenchymal stem cells that reside in adipose tissue as one of the major sources of adult stem cells might be responsible for complications related to diabetes type 2.20380516
ObesityDeregulated Nutrient SensingThe increased expression of myostatin, a secreted anabolic inhibitor of muscle growth and development, has been associated with obesity and insulin resistance.20386333
Inflammation, Hypoxia, Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingBecause mitochondrial dysfunction, inflammation, endoplasmic-reticulum stress and hypoxia all inactivate mTORC1, our results may suggest a unifying mechanism for the pathogenesis of insulin resistance in T2D, although the underlying causes might differ.20386866
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined insulin signaling in adipocytes from T2D patients, and contrary to findings in animal studies, we observed attenuation of insulin activation of mammalian target of rapamycin (mTOR) in complex with raptor (mTORC1).20386866
Diastolic dysfunction, HyperglycemiaDeregulated Nutrient SensingHyperglycaemia and insulin resistance have been linked to diastolic dysfunction experimentally.20386878
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlterations of insulin resistance and the serum adiponectin level in patients with type 2 diabetes mellitus under the usual antihypertensive dosage of telmisartan treatment.20388049
Complications of Diabetes MellitusDeregulated Nutrient SensingInsulin resistance plays a central role in the pathophysiology of diabetes complications.20388049
Diabetes MellitusDeregulated Nutrient SensingThe data indicate that the usual antihypertensive dosage of telmisartan improves insulin resistance and changes adiponectin effect in patients with diabetes mellitus.20388049
Impaired cognitionDeregulated Nutrient SensingHowever, the link between elevated fasting glucose levels and insulin resistance in nondiabetic individuals, and the risk of cognitive impairment is unclear.20393152
Diabetes MellitusDeregulated Nutrient SensingElevated fasting glucose levels and insulin resistance are not associated with worse cognitive function in older people without a history of diabetes.20393152
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo study the association of various systemic risk factors with retinal hard exudates in type 2 diabetic north Indian patients and to measure the incidence of dyslipidemia in them.20393241
DyslipidemiasDeregulated Nutrient SensingSerum cholesterol and LDL are independent risk factors for retinal hard exudates in type 2 diabetic north Indian patients who suffer from a remarkably high incidence of dyslipidemia.20393241
ARCN1 gene, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Hypertension, CTCAEDeregulated Nutrient SensingWhen compared with non-COPD patients, COPD patients were older and more likely to have diabetes, hypertension, and dyslipidemia.20394044
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance was found in 4% of patients, but no diabetes mellitus was detected in the 74 patients explored.20395666
Hypertension, CTCAE, Haiti, Diabetes MellitusDeregulated Nutrient SensingSubjects with MA had increased prevalence of hypertension (HT), insulin resistance and type 2 diabetes.20396921
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient Sensing[Prevalence of dyslipidemia and borderline dyslipidemia and other risk factors of coronary heart disease in residents from Beijing communities].20398568
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTo investigate the prevalence of dyslipidemia and borderline dyslipidemia and other coronary heart disease (CHD) risk factors in residents from Beijing communities.20398568
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIncidence of dyslipidemia and borderline dyslipidemia was 31.23% and 23.30% respectively, 71.17% residents have at least 1 CHD major risk factor and 20.23% residents were in borderline CHD risks.20398568
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingOver 1 out of 5 residents were in increased risk for borderline dyslipidemia or CHD risks.20398568
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIntensive control of dyslipidemia and CHD risk factors are warranted in Beijing residents.20398568
Glucose Intolerance (disease), HypertriglyceridemiaDeregulated Nutrient SensingGlucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia.20404017
Cardiovascular Diseases, Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHypertriglyceridemia (HTG) is one of the key features of dyslipidemia in type 2 diabetes, caused by the overproduction and/or decreased clearance of triglyceride (TG)-rich lipoproteins, and significantly promotes the development of cardiovascular diseases in diabetes.20404017
No Cardiac Valve Regurgitation, Dyslipidemias, OverweightDeregulated Nutrient SensingRecent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation.20405030
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingPrevention of stroke includes modifying risk factors, like dyslipidemias.20405669
Hyperlipidemia, Impaired T cell functionDeregulated Nutrient SensingArecoline-induced fat cell dysfunction may lead to hyperlipidemia and hyperglycemia/insulin-resistance.20406654
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDietary carbohydrates have been associated with dyslipidemia, a lipid profile known to increase cardiovascular disease risk.20407058
Cardiovascular morbidity, Hypertensive (finding), Glucose Intolerance (disease)Deregulated Nutrient SensingThe NAGOYA HEART Study is a prospective randomized open-label blinded-endpoint study to compare an angiotensin II receptor blocker, valsartan, and a calcium channel blocker, amlodipine, regarding their efficacies on cardiovascular morbidity and mortality in Japanese hypertensive patients with glucose intolerance.20409690
Dyslipidemias, Cardiovascular Diseases, Overweight, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, the 27-month community-based lifestyle modification of cardiovascular disease risks shows significant reductions in risks of diabetes, overweight and dyslipidemia in middle-aged Japanese.20410682
MalocclusionDeregulated Nutrient SensingHowever, we show that mice lacking at least one allele of both Sirt1 and Igfbp1 genes have a much higher incidence of malocclusion.20412791
TG gene, HypercholesterolemiaDeregulated Nutrient SensingPo-husk, apart from lowering LDL-C, also reduced TG, TG related to certain gene variants, TC, Apo B-100, oxLDL, insulin-resistance and systolic BP in mild-moderate hypercholesterolaemic individuals.20413122
Inflammation, Diabetes MellitusDeregulated Nutrient SensingRelation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naive diabetes obese patients.20413173
Inflammation, diabeticDeregulated Nutrient SensingThe aim of the present study was to explore the relationship of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naive diabetic patients.20413173
Carotid Atherosclerosis, Asthma, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDefined carotid atherosclerosis was diagnosed in 51 of the asthmatic patients, who were older, with a higher prevalence of males, a higher prevalence of dyslipidaemia and a lower mean daily dose of ICS than the 99 patients without carotid atherosclerosis.20413534
Carotid Atherosclerosis, DyslipidemiasDeregulated Nutrient SensingStepwise multiple logistic regression analysis identified age, male sex and dyslipidaemia as positive risk factors for carotid atherosclerosis.20413534
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient Sensing62% of patients reported comorbidities; systemic hypertension (35%), dyslipidaemia (13%), diabetes (12%) and coronary disease (11%) were the most frequent.20413540
Hyperlipidemia, ObesityDeregulated Nutrient SensingAdditional genetic mutations and environmental factors, including insulin resistance and obesity, may contribute to the development of type III hyperlipidemia.20413671
Endothelial dysfunction, Diabetes MellitusDeregulated Nutrient SensingAnimal models of diabetes have shown that low plasma H(2)S levels are associated with marked endothelial dysfunction and insulin resistance.20414636
Cardiovascular DiseasesDeregulated Nutrient SensingTo determine the association between ASIC3 genetic polymorphisms and insulin resistance in Taiwanese, 606 unrelated subjects with no history of cardiovascular disease were recruited during routine health examinations.20416288
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.20418489
DyslipidemiasDeregulated Nutrient SensingAll the patients had dyslipidemia which reached normal levels after surgery.20419504
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingHigh-prevalence risk factors were dyslipidemia (83.1%), hypertension (39.3%), and overweight (42.2%) with pervasive clustering of these risks.20419873
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingBeing older was related to increased cardiovascular disease risk, except for dyslipidemia.20419873
Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingA high percentage of persons being prescribed drug treatment for dyslipidemia and hypertension failed to reach authoritative targets for cardiovascular disease risk reduction.20419873
Dyslipidemias, Paraplegia, Overweight, Hypertension, CTCAEDeregulated Nutrient SensingSwedish persons with paraplegia are at high risk for dyslipidemia, hypertension, and overweight.20419873
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingPharmacotherapy for dyslipidemia and hypertension often failed to achieve recommended targets.20419873
Proteinuria, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingA logistic regression analysis adjusted for age and gender showed that CAAC was significantly associated with age, hypertension, dyslipidemia, serum albumin, calcium-phosphorus product, proteinuria and CAP.20420796
Alzheimers Disease", Impaired cognition, millicurieDeregulated Nutrient SensingInsulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease.20423560
Diabetes MellitusDeregulated Nutrient SensingChromium (Cr) supplementation improves glucose disposal in patients with insulin resistance and diabetes.20423560
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased serum ferritin concentrations in nonpathologic conditions, reflecting subclinical iron overload, have been reported to be associated with insulin resistance and an increased risk of type 2 diabetes mellitus (DM).20423745
IFNG wt Allele, Metabolic Syndrome XDeregulated Nutrient SensingIncreased serum concentrations of ferritin are associated with insulin resistance, type 2 DM, IFG, and metabolic syndrome in men, but only with IFG in women.20423745
bleomycin/cisplatin/vinblastine protocol, Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingAs compared to controls, the frequency of hypertension, obesity, smoking, dyslipidemia, diabetes mellitus and a family history of stroke or CVD was increased significantly in VBD subjects.20424441
Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingThese results indicate that impairments in cognitive functioning associated with metabolic syndrome and type 2 diabetes may begin as early as middle age and are primarily due to insulin resistance.20424454
TG gene, DyslipidemiasDeregulated Nutrient SensingThe total cholesterol, triglyceride (TG) or low density lipoprotein (LDL) levels more than 95th percentile for age and gender or high density lipoprotein (HDL) less then 35 mg/dL was defined as dyslipidemia.20427895
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThe relative increase in hfPWV remained significant after adjustment for age, sex, hypertension, pulse rate, smoking, diabetes mellistus, dyslipidemia, and chronic kidney disease.20430390
Impaired cognition, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingStudies have suggested that insulin resistance plays a role in cognitive impairment in individuals with type 2 diabetes.20435794
millicurie, Impaired cognition, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe aimed to determine whether an improvement in insulin resistance could explain cognitive performance variations over 36 weeks in older individuals with mild cognitive impairment (MCI) and type 2 diabetes.20435794
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFactors associated with psychological insulin resistance in individuals with type 2 diabetes.20435797
Diabetes MellitusDeregulated Nutrient SensingDiabetes self-efficacy and better interaction with clinicians were important in decreasing patients' reluctance to use insulin, known as psychological insulin resistance.20435797
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 diabetes.20436182
ObesityDeregulated Nutrient SensingUpregulated cholesterol synthesis was associated with peripheral insulin resistance independent of obesity.20436182
Demographics Domain, ObesityDeregulated Nutrient SensingThe precise mechanism by which obesity leads to insulin resistance and to DM is not completely described but it may be related to several biochemical factors, such as abnormalities in free fatty acids, adipokines, leptin and other substances (Tab.20437822
Kidney Failure, Chronic, Dyslipidemias, Precocious atherosclerosisDeregulated Nutrient SensingDyslipidemia, a prominent feature of end-stage renal disease, is considered a risk factor for premature atherosclerosis in hemodialysis (HD) patients.20438514
Renal function, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is related to loss of kidney function as well as use of low-flux cellulosic dialyzer membranes, but the effects of dialysate purity are unknown.20438514
Triglycerides, Systemic Inflammatory Response Syndrome, DyslipidemiasDeregulated Nutrient SensingCompared to baseline, treatment with conventional (mildly contaminated) dialysate significantly increased the uremic low-grade systemic inflammatory response syndrome (SIRS), augmented uremic dyslipidemia (triglycerides by +21%, and high-density lipoprotein (HDL) cholesterol by -10%) and enhanced oxidative stress.20438514
Systemic Inflammatory Response Syndrome, DyslipidemiasDeregulated Nutrient SensingIn contrast, the use of ultrapure dialysate significantly decreased uremia-associated SIRS, dyslipidemia (triglycerides -7% and HDL cholesterol +11%) and oxidative stress.20438514
DyslipidemiasDeregulated Nutrient SensingUltrapure dialysis fluid improves potential parameters of cardiovascular risk by decreasing inflammatory reactions, improving uremic dyslipidemia and lowering oxidative stress.20438514
Weight GainDeregulated Nutrient SensingHowever, high beverage energy and fructose intake may lead to weight gain and insulin resistance, respectively.20439553
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics.20444421
Mitochondrial abnormalitiesDeregulated Nutrient SensingWe examined whether variation in PARL protein content is associated with mitochondrial abnormalities and insulin resistance.20444421
HyperglycemiaDeregulated Nutrient SensingThis could be of importance for the metabolic aberrations associated to postsurgical complications, such as insulin resistance and hyperglycemia.20444921
Hypertensive (finding)Deregulated Nutrient SensingSalt sensitivity of blood pressure is strongly associated with insulin resistance in lean, essential hypertensive patients.20444953
Dyslipidemias, Retinal Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia and hypertension in patients with type 2 diabetes and retinopathy.20446438
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is associated with dyslipidemia and higher cardiovascular risk and also generates multiple microvascular complications.20446438
Dyslipidemias, Retinal Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Unspecified visual lossDeregulated Nutrient SensingWe found a statistically significant correlation between retinopathy and dyslipidemia, which suggested that the use of systemic lipid lowering therapy in type 2 diabetes is of benefit in patients with retinal changes, in order to prevent visual loss.20446438
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingPresence of other risk factors (diabetes and dyslipidemia) was independently associated with higher hypertension rates.20448534
DyslipidemiasDeregulated Nutrient SensingIn conclusion, these results suggest that the increase in LDL cholesterol that occurred with the addition of P-OM3 to simvastatin therapy in subjects with mixed dyslipidemia was confined predominantly to those with low LDL cholesterol levels while receiving simvastatin monotherapy.20451686
Lipodystrophy, ObesityDeregulated Nutrient SensingManagement of severe insulin resistance (IR) is a major clinical challenge in many patients with obesity or lipodystrophy, and also in rarer patients with proven or suspected genetic defects in the insulin receptor or downstream signalling.20455892
Asthma, MS4A2 wt Allele, ObesityDeregulated Nutrient SensingObesity, insulin resistance and the prevalence of atopy and asthma in US adults.20456316
Asthma, MS4A2 wt Allele, ObesityDeregulated Nutrient SensingThe roles of obesity and insulin resistance in asthma and atopy are not well understood.20456316
Asthma, MS4A2 wt Allele, ObesityDeregulated Nutrient SensingWe investigated whether there is an association of obesity and insulin resistance with asthma and atopy prevalence in US adults.20456316
MS4A2 wt Allele, ObesityDeregulated Nutrient SensingNeither obesity measure nor insulin resistance was associated with atopy.20456316
Asthma, ObesityDeregulated Nutrient SensingObesity was positively associated with asthma overall (odds ratio [OR] for obese vs normal BMI = 2.28, 95% CI: 1.76, 2.96; OR for obese vs normal waist circumference = 1.75; 95% CI: 1.22, 2.51) but insulin resistance was not (OR = 1.26; 95% CI: 0.80, 1.98).20456316
Asthma, ObesityDeregulated Nutrient SensingObesity remained independently associated with all asthma outcomes after controlling for insulin resistance.20456316
Asthma, Obesity, AtopyDeregulated Nutrient SensingObesity was independently associated with asthma, and atopic and nonatopic asthma, after controlling for insulin resistance and socio-demographic factors.20456316
Asthma, MS4A2 wt AlleleDeregulated Nutrient SensingThere was no evidence that insulin resistance was associated with atopy or asthma.20456316
Liver carcinoma, Hepatitis CDeregulated Nutrient SensingInsulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection.20458764
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingTo elucidate the role of insulin resistance (IR) and serum adiponectin level in hepatocellular carcinoma (HCC) associated with chronic hepatitis C. Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed HCC.20458764
Hepatitis C, Diabetes Mellitus, FAM126A geneDeregulated Nutrient SensingInsulin resistance measured by HOMA-IR, regardless of the presence of diabetes, is significantly associated with HCC development in patients with chronic HCV infection.20458764
Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingWeight loss in patients with type 2 diabetes can improve glycemic control, lower blood pressure, and improve dyslipidemia.20460445
LipolysisDeregulated Nutrient SensingThe positive correlation between subcutaneous adipose tissue AMPK and adiponectin or the evoked lipolysis rate could indicate a protective role of AMPK in this tissue, counteracting insulin resistance in morbid obese patients.20462511
ObesityDeregulated Nutrient SensingAdenine monophosphate (AMP) activated protein kinase (AMPK) is an important regulator of obesity.20462511
ObesityDeregulated Nutrient SensingDifferences in AMPK expression between subcutaneous and visceral adipose tissue in morbid obesity.20462511
Diabetes MellitusDeregulated Nutrient SensingFINDRISC was the best single indicator of prevalent undiagnosed diabetes among all variables tested and strongly associated with insulin resistance.20463095
Diabetes Mellitus, Obesity, AtherosclerosisDeregulated Nutrient SensingSkin tags are dermatological lesions commonly found in the general population and have been associated with diabetes mellitus, obesity, insulin resistance and atherosclerosis.20464083
Overweight, ObesityDeregulated Nutrient SensingPatients with obesity or overweight, in comparison to those with normal BMI, showed insulin resistance and a higher concentration of high sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor 1 (PAI-1), and interleukin 6 (Il-6).20464701
HyperlipidemiaDeregulated Nutrient SensingExercise training is advocated in insulin resistance and statins are used to treat hyperlipidaemia, two cardiometabolic risk factors often presenting concurrently.20465545
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMany authors have suggested that insulin resistance could raise both incidence and mortality of coronary heart disease (CHD).20466373
Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk.20467002
IFNG wt AlleleDeregulated Nutrient SensingConsidering the role of caloric restriction in increasing the intestinal uptake of carnitine, the results suggest that oral L-carnitine administration, when associated with a hypocaloric feeding regimen, improves insulin resistance and may represent an adjunctive treatment for IFG and DM-2.20467011
DyslipidemiasDeregulated Nutrient SensingEfficacy of low dose atorvastatin in diabetic dyslipidaemia.20469785
Atherosclerosis, Hyperglycemia, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingOur study further confirms the importance of intensive examinations for the early detection of atherosclerosis and positive treatments for hypertension, dyslipidaemia, obesity, as well as hyperglycaemia are necessary when a reduced eGFR is found in diabetic patients.20470427
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is frequently associated with diabetes and cardiovascular disease.20470939
Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Heart failure, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingNo significant differences were found in age, sex, hypertension, dyslipidemia, smoking, diabetes mellitus, ischemic heart disease, heart failure, bronchopathy, or renal failure between groups.20472389
Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingStroke survivors were more likely to be treated for hypertension (92.4% v 89.0%, P < .0001), diabetes (88.3% v 81.4%, P < .0001), and dyslipidemia (76.3% v 61.9%, P < .0001).20472464
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance.20472517
Sample Size Calculation, DyslipidemiasDeregulated Nutrient SensingPatients with SSc exhibited mild dyslipidaemia expressed mainly by low serum levels of HDL-C and high TC (p < 0.001 and p < 0.021, respectively) compared to controls.20476856
Microalbuminuria, InfarctionDeregulated Nutrient SensingPatients with microalbuminuria exhibit a larger infarct size as indicated by higher values of troponin I. Microalbuminuria was associated with higher values of glucose and a higher prevalence of insulin resistance.20479654
Hyperglycemia, glucose metabolismDeregulated Nutrient SensingInterestingly it was associated with acute glucose dysmetabolism (as inferred by hyperglycemia and the prevalence of insulin resistance), thus suggesting that it can be considered part of the acute metabolic response to the acute coronary event.20479654
Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe goal of this study was to evaluate the effect of Roux-en-Y gastric bypass (RYGBP) on 2 metabolic disorders, diabetes and dyslipidemia, in obese type 2 diabetes mellitus (T2DM) patients.20485144
Acute lymphocytic leukemiaDeregulated Nutrient SensingImpaired glucose tolerance and insulin resistance in survivors of childhood acute lymphoblastic leukemia: prevalence and risk factors.20485196
Acute lymphocytic leukemia, Metabolic Syndrome XDeregulated Nutrient SensingSurvivors of acute lymphoblastic leukemia (ALL) are at increased risks of impaired glucose metabolism, insulin resistance, and metabolic syndrome.20485196
FAM126A geneDeregulated Nutrient SensingFurthermore, insulin resistance was significantly higher in the HCC patients than the healthy subjects (P=0.027).20486202
FAM126A geneDeregulated Nutrient SensingIn addition, the significant correlations of serum IGF-1 levels with age and insulin resistance in the healthy subjects were not noted in the HCC patients.20486202
Cessation of lifeDeregulated Nutrient SensingThese data suggest that the SIRT1-PARP-1 axis plays a critical role in the regulation of CS-induced autophagy and have important implications in understanding the mechanisms of CS-induced cell death and senescence.20493163
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdjustments were made for age, smoking, type 2 diabetes mellitus, insulin resistance (HOMA-IR) and medication use.20494358
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAbdominal adiposity and low cardiorespiratory fitness are associated with insulin resistance in people with impaired glucose tolerance and type 2 diabetes.20495292
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, little is known about which factor precedes insulin resistance in people with impaired glucose tolerance and type 2 diabetes, and which is the stronger predictor of insulin resistance in non-diabetic people.20495292
DyslipidemiasDeregulated Nutrient Sensing[Sporobakterin impact on atherogenic dyslipidemia at patients with intestinal dysbacteriosis].20496791
diabeticDeregulated Nutrient SensingThe preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HGF and insulin resistance in type 2 diabetic patients not receiving insulin treatment.20497462
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results of this preliminary study indicate that the presence of WML was associated with the high HGF and insulin resistance in Japanese patients with type 2 diabetes mellitus.20497462
Obesity, Visceral, Dyslipidemias, Dysglycemia, Hypertension, CTCAEDeregulated Nutrient SensingVisceral obesity is a central component but other major facets such as hypertension, dyslipidemia, or dysglycemia are often present.20497845
Renal Insufficiency, Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe severity of renal histopathological findings in patients who underwent nephrectomy for resistant hypertension correlated with an increased prevalence of cardiovascular disease, a greater degree of renal dysfunction and more severe dyslipidaemia.20501460
Prostate carcinomaDeregulated Nutrient SensingGiven discrepancies between preclinical and clinical observations of mammalian target of rapamycin (mTOR) inhibition in prostate cancer, we sought to determine the pharmacodynamic effects of the mTOR/TORC1 inhibitor rapamycin in men with intermediate- to high-risk prostate cancer undergoing radical prostatectomy.20501622
HypercholesterolemiaDeregulated Nutrient SensingElevated serum chemokine CXC ligand 5 levels are associated with hypercholesterolemia but not a worsening of insulin resistance in Chinese people.20501684
Glucose Intolerance (disease)Deregulated Nutrient SensingThe age-related increase in glucose intolerance may not be fully explained by the defect in HOMA-IR and HOMA-B.20503256
Chronic heart failureDeregulated Nutrient SensingThe early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood.20504866
Heart failureDeregulated Nutrient SensingThe risk of heart failure was further increased by rapid gain in body mass index after the age of 2 years, a path of growth known to be linked to insulin resistance in later life.20504866
Hypertension, CTCAE, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingFifty-six patients (42%) had central adiposity, 62 (46%) had hypertension, 46 (34%) had type 2 diabetes, seven (5%) had coronary artery disease, and 48 (36%) had dyslipidemia.20505515
Macular edema due to diabetes mellitus, Dyslipidemias, Disorder of macula due to diabetes mellitus, Diabetes MellitusDeregulated Nutrient SensingOral atorvastatin therapy in patients with diabetes mellitus and dyslipidemia seems to reduce the severity of hard exudates and fluorescein leakage in diabetic maculopathy and could be useful as an adjuvant therapy in the management of diabetic macular edema.20507015
Diabetes MellitusDeregulated Nutrient SensingIncreasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin resistance.20508082
Diabetes MellitusDeregulated Nutrient SensingType 2 DM is the commonest form of diabetes, which is characterized by insulin resistance.20509325
Prediabetes syndromeDeregulated Nutrient SensingInsulin resistance can be preceded by long term abnormality in glucose homeostasis which is called pre-diabetes.20509325
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAt baseline, 77.9% of patients were smokers, 45.2% had hypertension, 73.1% had dyslipidemia, 7.7% had diabetes, and 48.1% had a family history of CAD.20513067
Cardiovascular DiseasesDeregulated Nutrient Sensing[Association between the risk factors of cardiovascular diseases and insulin resistance].20513276
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo explore the association between risk factors of cardiovascular diseases (CVD) and insulin resistance in a cross-sectional study.20513276
TG gene, Hyperuricemia, ObesityDeregulated Nutrient SensingSex (OR = 1.75), low HDL-C (OR = 1.80), hyperuricemia (OR = 2.11), high TG (OR = 2.14) and central obesity (OR = 2.68) appeared to be independently correlated to insulin resistance in multiple logistic regression analysis.20513276
TG gene, Hyperuricemia, ObesityDeregulated Nutrient SensingThe risk factors of CVD as low HDL-C, high TG, central obesity and hyperuricemia were independently correlated to insulin resistance.20513276
Colorectal NeoplasmsDeregulated Nutrient SensingOur findings provide the first epidemiologic evidence for interactive effects of adiponectin and leptin in the early stage of colorectal tumorigenesis, distinct from their involvement in insulin resistance.20516125
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of serum lipoprotein ratios with insulin resistance in type 2 diabetes mellitus.20516535
TG gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTC/HDL-C ratio, TG/HDL-C, ratio, Non-HDL-C, WC, TG, and TC can be used as the markers of insulin resistance and CVD risk in T2D patients.20516535
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingEfficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia.20518948
Hyperglycemia, Hypertension, CTCAE, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingLEP I/G combined genotypes were not associated with hypertension, hyperglycemia, dyslipidemia and coronary artery disease.20520958
RestenosisDeregulated Nutrient SensingThe degree of insulin resistance, FPG, RVD, SA, and SV were correlated with restenosis.20521015
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingPAD was strongly correlated with age and dyslipidemia in both sexes, carotid atherosclerosis in males, and abdominal fat in females.20523009
Impaired cognitionDeregulated Nutrient SensingCognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance.20524222
Impaired cognition, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine whether the cognitive impairments observed in adults with type 2 diabetes mellitus (T2DM) exist in preclinical disease, we compared 38 adult participants with evidence of insulin resistance (IR) to 54 age-, gender-, and education-matched control participants on a battery of neuropsychological tests.20524222
Dyslipidemias, Overweight, GDC Comorbidity Terminology, ObesityDeregulated Nutrient SensingBMI is linearly related to the total cholesterol, LDL cholesterol and triglyceride concentrations and is, however, inversely related with HDL cholesterol, Dyslipidaemia has been recognized to be strongly associated with overweight and obesity and its comorbid conditions.20524492
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia show an increasing trend with age in both male and female subjects.20524492
DyslipidemiasDeregulated Nutrient SensingIn females, dyslipidaemia shows a gradual increase with age for all BMI categories.20524492
DyslipidemiasDeregulated Nutrient SensingThere is increase in dyslipidaemia trend in our subjects with increase in BMI and age.20524492
Chronic heart failure, Endothelial dysfunctionDeregulated Nutrient SensingComplement activation, endothelial dysfunction, insulin resistance and chronic heart failure.20524927
Obesity, Abdominal, Cardiovascular Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAbdominal obesity is associated with type 2 diabetes, cardiovascular disease, dyslipidemia and hypertension.20525471
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAbdominal obesity is very frequently found in Danish primary care patients, and it is associated with an increased prevalence of diabetes, dyslipidemia and hypertension.20525471
Abnormality of mitochondrial metabolismDeregulated Nutrient SensingStudies have suggested a link between insulin resistance and mitochondrial dysfunction in skeletal muscles.20526759
Obesity, Diabetes MellitusDeregulated Nutrient SensingFatty liver is known to be linked with insulin resistance, alcohol intake, diabetes and obesity.20529259
ObesityDeregulated Nutrient SensingAs shown in the in vitro analysis, the low-grade proinflammatory environment and the insulin resistance associated with obesity may contribute to downregulate LPIN1 in adipose tissue, leading to a worse metabolic profile.20530740
Liver damageDeregulated Nutrient SensingTo improve her insulin resistance, we administered pioglitazone therapy for 1 week; however, subsequent laboratory findings did not indicate any improvement in her liver damage.20530928
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGestational diabetes mellitus is defined as glucose intolerance that first occurs or is first identified during pregnancy.20530932
Hypercholesterolemia, Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingRosuvastatin, a statin indicated for patients with primary hypercholesterolemia, mixed dyslipidemia and familial hypercholesterolemia, is well tolerated by most patients.20531065
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingStudent forum: Does calcium and vitamin D intake affect incidence of type 2 diabetes mellitus and insulin resistance syndrome?20534409
Increased insulin level, Obesity, Abdominal, Dyslipidemias, Heart Diseases, Hypertension, CTCAEDeregulated Nutrient SensingHyperinsulinemia, hypertension, abdominal obesity, dyslipidemia, and coagulation abnormalities-which contribute to insulin resistance syndrome-are major risk factors for T2DM and heart disease.20534409
Diabetes MellitusDeregulated Nutrient SensingAs our population ages, the risk of diabetes and insulin resistance will rise, so the question is whether calcium and vitamin D (D3, cholecalciferol) supplementation is necessary or is warranted at a greater or lesser degree than the current recommendations.20534409
Weight decreasedDeregulated Nutrient SensingRising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance.20534751
Weight decreasedDeregulated Nutrient SensingWeight loss of 10% after low-calorie diet increased 25OHD levels, and this increase was mainly associated with improvement of insulin resistance.20534751
ObesityDeregulated Nutrient SensingElevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population.20534760
Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingCompared with the lowest quartile of SUA, prevalence of abdominal obesity, hypertension, and dyslipidemia was significantly increased in the highest quartile in boys and that of abdominal obesity was increased in the highest quartile in girls.20534946
Glucose Intolerance (disease), Complications of Diabetes MellitusDeregulated Nutrient SensingThe consequences for live kidney donors with preexisting glucose intolerance without diabetic complication: analysis at a single Japanese center.20535851
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingIn CHC, insulin resistance is independently associated with the presence of genotypes 1/4.20536721
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe tested the hypothesis that an elevated level of HSCRP correlates with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes mellitus.20537668
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results indicate that the elevated level of HSCRP in Japanese nondementia patients with type 2 diabetes mellitus is characterized by increased hippocampus volume and insulin resistance, and that the z score and HOMA index are independent predictors of HSCRP.20537668
diabeticDeregulated Nutrient SensingClinical effectiveness and safety evaluation of long-term pioglitazone treatment for erythropoietin responsiveness and insulin resistance in type 2 diabetic patients on hemodialysis.20540652
AnemiaDeregulated Nutrient SensingWe determined the efficacy of pioglitazone by monitoring anemia, glycemic control, insulin resistance, and levels of inflammatory cytokines and high-molecular-weight (HMW) adiponectin for 96 weeks.20540652
ETV3 wt AlleleDeregulated Nutrient SensingWhile the C/A ratio provided little advantage to predict MetS, it might be more useful to predict insulin resistance than CRP or HMW adiponectin alone.20543521
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingHistory of myocardial infarction and medication for dyslipidaemia, hypertension, and diabetes mellitus were also recorded.20544162
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe prevalences of diabetes mellitus (5.9%), dyslipidaemia (11.1%), and hypertension (14.1%) were also significantly higher in the paraplegic group, as were drug treatment for these disorders.20544162
Dyslipidemias, Paraplegia, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingPersons with paraplegia report increased prevalences of diabetes mellitus, hypertension, and dyslipidaemia, in particular, compared with the general population.20544162
Diabetes MellitusDeregulated Nutrient SensingRelationship between plasma uridine and insulin resistance in patients with non-insulin-dependent diabetes mellitus.20544544
Hypertensive (finding)Deregulated Nutrient SensingFurthermore, it was recently reported that plasma uridine is correlated with homeostasis model assessment of insulin resistance (HOMA-R) in hypertensive patients.20544544
NEUROD1 wt AlleleDeregulated Nutrient SensingWe found a positive relationship between plasma uridine value and HOMA-R, serum insulin, and CPR, suggesting that plasma uridine is a marker of insulin resistance in patients with NIDDM.20544544
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe main risk factors were hypertension (60.5%), dyslipidemia (42.9%), smoking (45.1%) and diabetes (23.9%, of whom 13.2% were on insulin therapy).20545251
Demographics DomainDeregulated Nutrient SensingTo identify the relationship between insulin resistance and sympathetic activity, we examined muscle sympathetic nerve activity (MSNA) in controlled type 2 DM patients with alpha-glucosidase inhibitor (GI).20547473
Glucose Intolerance (disease), Blood GlucoseDeregulated Nutrient SensingBlack persons have higher HbA(1c) levels than white persons across the full spectrum of glycemia, and the differences increase as glucose intolerance worsens.20547905
Liver carcinoma, Metabolic Syndrome X, FAM126A geneDeregulated Nutrient SensingMetabolic syndrome and insulin resistance have been linked to increased risk of occurrence and mortality of hepatocellular carcinoma (HCC).20549233
DyslipidemiasDeregulated Nutrient SensingHowever, relevant patients with atherogenic dyslipidemia represented less than 17 percent of the ACCORD Lipid population (941 out of 5518 patients).20550659
DyslipidemiasDeregulated Nutrient SensingAmong all other 4548 patients without atherogenic dyslipidemia such rates were 10.1% in both fenofibrate and placebo study groups.20550659
DyslipidemiasDeregulated Nutrient SensingTherefore, an important finding of ACCORD Lipid study was the observation that fibrates may lead to cardiovascular risk reduction in patients with atherogenic dyslipidemia not only as monotherapy but in combination with statins as well.20550659
DyslipidemiasDeregulated Nutrient SensingIn conclusion, in patients with atherogenic dyslipidemia (high triglycerides and low HDL-C, fibrates -- either as monotherapy or combined with statins - were associated with reduced risk of cardiovascular events.20550659
Glycogen storage disease type IIDeregulated Nutrient SensingInhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease.20554235
Sarcopenia, AtherosclerosisDeregulated Nutrient SensingMany predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which is another leading cause of morbidity and mortality in elderly subjects.20554280
Hypertension, CTCAE, Obesity, PrehypertensionDeregulated Nutrient SensingObesity, abnormalities of glucose metabolism and insulin resistance were the major factors associated with prehypertension and hypertension.20555358
Dyslipidemias, diabeticDeregulated Nutrient SensingImpact on dyslipidemia of the laparoscopic ileal interposition associated to sleeve gastrectomy in type 2 diabetic patients.20556664
DyslipidemiasDeregulated Nutrient SensingDyslipidemia is known to increase significantly the odds of major cardiovascular events in the general population.20556664
DyslipidemiasDeregulated Nutrient SensingThe objective of the study was to evaluate the control of dyslipidemia in patients with T2DM and BMI below 30 that were submitted to the laparoscopic ileal interposition associated to sleeve gastrectomy.20556664
DyslipidemiasDeregulated Nutrient SensingThe laparoscopic ileal interposition associated to sleeve gastrectomy was an effective operation for the regression of dyslipidemia and T2DM in a non-obese population.20556664
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThis type of dyslipidaemia frequently appears in patients with chronic kidney disease (CKD).20562093
DyslipidemiasDeregulated Nutrient SensingProspective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia.20562628
DyslipidemiasDeregulated Nutrient SensingWhether these concentrations are prospectively associated with an adverse lipid profile and an increased risk of incident dyslipidemia has not yet been investigated.20562628
DyslipidemiasDeregulated Nutrient SensingLow total testosterone concentrations are prospectively associated with an adverse lipid profile and increased risk of incident dyslipidemia.20562628
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTreatment with atypical antipsychotic agents is often complicated by dyslipidemia, which is a risk factor for cardiovascular disease.20562674
TG geneDeregulated Nutrient SensingAlthough the association between BMI and both HDL and TG may be explained by insulin resistance, the lack of a significant association between BMI and LDL remains an unexpected finding that requires further investigation.20563664
Diabetes Mellitus, Non-Insulin-Dependent, square decimeterDeregulated Nutrient SensingA single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects.20566590
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingThe negative impact of diabetes mellitus is well recognized, yet little is known about the effect of this disease on the liver, an organ susceptible to nonalcoholic fatty liver disease related to insulin resistance.20566726
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingCompared two studies,the exposed rates of hypertension, abdominal obesity, dyslipidemia were increased from 26.82%, 26.39%, 20.45% to 29.82%, 46.1%, 44.20%.20568459
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia and cardiovascular disease: a series of epidemiologic studies in Japanese populations.20571251
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingFurthermore, even when analysis is restricted to ischemic stroke, the relationship between dyslipidemia and stroke is very weak.20571251
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingAccordingly, it is difficult to perform cohort studies of dyslipidemia and cardiovascular disease.20571251
Glucose Intolerance (disease), Obesity, AbdominalDeregulated Nutrient SensingForty men with abdominal obesity and glucose intolerance were randomized in a prospective, 12-month double-blind trial to receive either GH or placebo.20572419
metabolic disturbanceDeregulated Nutrient SensingInsulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin.20573249
Glucose Intolerance (disease), Pancreatitis, ChronicDeregulated Nutrient SensingGlucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis.20573586
Glucose Intolerance (disease)Deregulated Nutrient SensingIn the CP groups, significant differences (increasing with the degree of glucose intolerance) in glucagon responses during the first hour of OGTT compared to IVGTT were observed (CP+NGT: -13 + or - 22 vs. -88 + or - 17, p = 0.02; CP+IGT: 3 + or - 17 vs. -87 + or - 19, p = 0.01; CP+DM: 94 + or - 27 vs. -78 + or - 16 1 h x pmol/l (mean + or - SEM), p<0.001).20573586
Prediabetes syndrome, AtherosclerosisDeregulated Nutrient SensingA1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRAS).20573754
Metabolic DiseasesDeregulated Nutrient SensingSingle determinations of FPG and 2-h plasma glucose seem to be more precise correlates of insulin resistance and secretion than A1C and, in general, better for other metabolic disorders.20573754
Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemias and physicochemical changes in low-density lipoprotein (LDL) are very important factors for the development of coronary artery disease (CAD).20574778
IschemiaDeregulated Nutrient SensingInsulin resistance (IR) results in higher FFA concentrations and impaired myocardial glucose use, potentially worsening ischemia.20576156
Prediabetes syndrome, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe association between prediabetes as currently defined and incident diabetes in populations with widespread obesity, insulin resistance syndrome, and diabetes is not well defined.20578203
Albuminuria, ObesityDeregulated Nutrient SensingMeasures of obesity, A(1c), FPG, 2-h PG, FI, albuminuria, and insulin resistance (IR) help predict this conversion.20578203
DyslipidemiasDeregulated Nutrient SensingSecondary prevention in the form of early detection of dyslipidemia and risk modification via drug and non-drug procedures, particularly among the high-risk group, is thus imperative.20578501
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingType 2 diabetes mellitus is associated with dyslipidemia and with an increased risk of coronary heart disease (CHD).20580029
InflammationDeregulated Nutrient SensingObesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance.20581149
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingBiochemical tests revealed hyperglycemia and dyslipidemia on the next day.20584318
Diabetes, AutoimmuneDeregulated Nutrient Sensing[Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults].20584648
Diabetes, AutoimmuneDeregulated Nutrient SensingTo investigate the relation between insulin resistance and glutamic acid decarboxylase antibody (GAD-Ab) titers in latent autoimmune diabetes in adults (LADA).20584648
OvergrowthDeregulated Nutrient SensingIn LGA pre-pubertal children the severity of intrauterine overgrowth was associated with the insulin resistance indices.20585203
HIV-1 Infection Pathway, Acute infectious diseaseDeregulated Nutrient SensingBryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.20585398
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingThe ENSANUT 2006 data confirm that the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high.20585729
Hypertension, CTCAEDeregulated Nutrient SensingCorrelation between the Indexes of Insulin Resistance and Renal Function in the Presence of Hypertension.20588057
Hypertension, CTCAE, HaitiDeregulated Nutrient SensingThere have been no reports on the relationship between insulin resistance and renal function in the presence of hypertension (HT).20588057
HaitiDeregulated Nutrient SensingA clearer correlation between HOMA-IR and eGFR was observed in the non-HT group than the HT group, suggesting that HT may attenuate the direct correlation between the insulin resistance and renal function indices.20588057
Hypertensive (finding)Deregulated Nutrient SensingAdiposity contributes to the insulin resistance and endothelial dysfunction of the hypertensive state; the inflammatory network and the metalloprotease (MMP)/ tissue inhibitor of metalloprotease (TIMP) system modulate vascular structure and function.20589975
HIV, HIV-Associated Lipodystrophy Syndrome, HIV InfectionsDeregulated Nutrient SensingThe introduction of highly active antiretroviral therapy (HAART) has dramatically changed the prognosis of human immunodeficiency virus (HIV) infection, with a significant decline in morbidity and mortality.Changes in body fat distribution are a common finding in individuals with HIV infection being treated with antiretrovirals, and this condition (collectively termed lipodystrophy syndrome) is associated with depletion of subcutaneous fat, increased triglycerides and insulin resistance.20591174
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigh-dose vitamin D(3) improved systolic blood pressure and B-type natriuretic peptide levels, but not endothelial function, insulin resistance or glycosylated haemoglobin in patients with type 2 diabetes.20596692
Dyslipidemias, Obesity, Bipolar DisorderDeregulated Nutrient SensingObesity and dyslipidemia were particularly prevalent in patients with bipolar disorder.20599461
AtherosclerosisDeregulated Nutrient SensingHowever, the effects of SIRT1 loss-of-function on the endothelium in atherosclerosis remain to be characterized.20606253
atheroscleroticDeregulated Nutrient SensingWe observed no difference in endothelial relaxation and eNOS (Ser1177) phosphorylation between 20-week old male atherosclerotic ApoE-/- SIRT1+/- and ApoE-/- SIRT1+/+ mice.20606253
Sleep Apnea, Obstructive, Snoring, Osage languageDeregulated Nutrient SensingObstructive sleep apnea (OSA) and snoring are known independent risk factors for insulin resistance.20607426
Endothelial dysfunctionDeregulated Nutrient SensingAdipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction.20615436
Steatohepatitis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThis condition is characterized by severe dyslipidemia, insulin resistance, diabetes mellitus, and steatohepatitis.20616664
CardiomyopathiesDeregulated Nutrient SensingExtreme insulin resistance and the possibility of a "lipotoxic cardiomyopathy" should be entertained as possible explanations.20616664
Myocardial Ischemia, Cerebrovascular accidentDeregulated Nutrient SensingThis may represent a potential biological explanation to the beneficial effects of ACE-inhibition on stroke, ischemic heart disease and insulin resistance.20617288
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingResidual dyslipidaemia in patients treated with statins needs to be addressed to reduce the prevalence of cardiovascular disease in primary and secondary care.20619240
Dyslipidemias, Meibomian gland dysfunctionDeregulated Nutrient SensingAssociation of dyslipidemia in moderate to severe meibomian gland dysfunction.20619393
Dry Eye Syndromes, Dyslipidemias, Meibomian gland dysfunctionDeregulated Nutrient SensingTo determine whether meibomian gland disease, a major contributor to dry eye syndrome, is associated with dyslipidemia.20619393
DyslipidemiasDeregulated Nutrient Sensingmain outcome measure: The prevalence of dyslipidemia (elevated total cholesterol, elevated LDL, decreased HDL, or elevated triglycerides) in patients with moderate to severe MGD.20619393
DyslipidemiasDeregulated Nutrient SensingPatients with moderate to severe MGD had a higher incidence of dyslipidemia with respect to elevated total cholesterol (>200 mg/dL), 67.4% to 45.1% (P = .0012) when compared to population controls.20619393
DyslipidemiasDeregulated Nutrient SensingPatients with moderate to severe MGD have a higher incidence of dyslipidemia with respect to elevated total cholesterol than the general population.20619393
Metabolic DiseasesDeregulated Nutrient SensingThis study further supports a role for SELS in the development of metabolic disease, especially in the context of insulin resistance.20619427
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRandomized, open-label cross-over study investigating the effect of fenofibrate (160 mg), atorvastatin (10 mg), and combination of both in patients with type 2 diabetes mellitus and atherogenic dyslipidemia.20619837
Obesity, therapeutic hemodilutionDeregulated Nutrient SensingStudies suggest lowering the threshold of the prostate specific antigen test in obese men due to the hemodilution effect but prostate specific antigen may be affected by prostate volume and insulin resistance, which also increase with obesity.20620404
Dyslipidemias, Diabetes Mellitus, Heart failure, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingEligibility and claims data (2002-2004) were used to identify beneficiaries with dyslipidemia, hypertension, coronary artery disease (CAD), heart failure, or diabetes.20621868
Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe proportion of patients without a prescription fill for recommended medications varied by disease (43% hypertension, 40% dyslipidemia and CAD, and 25% diabetes and heart failure).20621868
Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMedication nonadherence was high (69% hypertension, 64% CAD, 57% heart failure, 48% dyslipidemia, 41% diabetes).20621868
Diabetes Mellitus, NEUROD1 wt AlleleDeregulated Nutrient SensingIdentification of insulin resistance (IR) in the general population is important for developing strategies to reduce the prevalence of non-insulin-dependent diabetes mellitus (NIDDM).20622341
Abnormality, DyslipidemiasDeregulated Nutrient SensingThe prevalence of MS manifestations among Arab children is extremely high, with dyslipidemia being the most common MS abnormality.20624169
Diabetes MellitusDeregulated Nutrient SensingTreatment with metformin to improve insulin resistance and address the diabetes proved successful.20625965
glycationDeregulated Nutrient SensingSerum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects.20626403
InflammationDeregulated Nutrient SensingSince oxidative stress and inflammation impair insulin actions as well, it is conceivable that AGEs may play some role in insulin resistance.20626403
Hypertension, CTCAE, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingAge and male sex but not hypertension or dyslipidemia were predictors of presence of obstructive coronary artery disease (Duke score >or=2).20626669
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient Sensing[Serum omega-3 polyunsaturated fatty acid and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease].20627036
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate the relationship between serum omega-3 polyunsaturated fatty acid (omega-3PUFA) and insulin resistance (IR) in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease (NAFLD).20627036
Dyslipidemias, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingOf these patients, 8 (67%) had diabetes, 8 (67%) had coronary artery disease and 10 (83%) had dyslipidaemia.20627865
ObesityDeregulated Nutrient SensingG protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.20627936
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance is associated with the pathogenesis of metabolic disorders as type 2 diabetes and obesity.20627936
Tumor necrosisDeregulated Nutrient SensingWe analyzed the influence of GRK2 levels in insulin signaling in myoblasts and adipocytes with experimentally increased or silenced levels of GRK2, as well as in GRK2 hemizygous animals expressing 50% lower levels of this kinase in three different models of insulin resistance: tumor necrosis factor-a (TNF-a) infusion, aging, and high-fat diet (HFD).20627936
diabeticDeregulated Nutrient SensingIntraoperative insulin resistance is associated with an increased risk of complications, independent of the patient's diabetic state.20631016
Weight decreasedDeregulated Nutrient SensingCirculating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss.20631025
Weight decreased, ObesityDeregulated Nutrient SensingDifferences in PEDF observed after weight loss were related to changes in obesity, insulin resistance, and blood pressure measures.20631025
Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingCriteria for obesity, hypertension, dyslipidemia and hyperglycemia were primarily those of World Health Organization (WHO) and the International Diabetes Federation.20634032
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingChromium supplementation does not appear to ameliorate insulin resistance or impaired glucose metabolism in patients at risk for type 2 diabetes and thus is unlikely to attenuate diabetes risk.20634174
Malignant tumor of colon, Primary malignant neoplasm, Dyslipidemias, ObesityDeregulated Nutrient SensingThese data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia.20634278
DyslipidemiasDeregulated Nutrient SensingThere was no significant association between increased CAWT and dyslipidemia or smoking.20634310
Burn Specimen Source CodesDeregulated Nutrient SensingInsulin resistance secondary to the hypermetabolic stress response persists in severely burned children when burn wounds are at least 95% healed.20634704
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingAtorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia.20637495
Pre-EclampsiaDeregulated Nutrient SensingMeanwhile, the results of our study suggest that insulin resistance and other cardiovascular risk factors are related to microvascular reactivity in middle-aged women with a history of preeclampsia.20637782
ObesityDeregulated Nutrient SensingPAI-1 and t-PA correlated with lipid parameters, markers of insulin resistance, blood pressure and obesity.20640487
DyslipidemiasDeregulated Nutrient SensingNon-LDL-related dyslipidaemia and coronary risk: a case-control study.20643700
vascular inflammations, Endothelial dysfunctionDeregulated Nutrient SensingResveratrol (RV)-induced SirT1 activation also improves endothelial dysfunction and suppresses vascular inflammation.20644332
atheroscleroticDeregulated Nutrient SensingSirT1 expression was decreased in aged and atherosclerotic vessels in vivo, and significantly reduced in endothelial cells purified from vessel tissues.20644332
atheroscleroticDeregulated Nutrient SensingOur data suggested that SirT1 could be a crucial factor involved in the endothelial cells of atherosclerotic CAGB patients and aging rats.20644332
Cardiovascular Diseases, Hypertriglyceridemia, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDiabetic dyslipidaemia, characterized by hypertriglyceridaemia as a result of elevated serum very-low-density lipoprotein (VLDL) concentrations, contributes to the increased risk of cardiovascular disease (CVD) in type 2 diabetes (T2DM).20649626
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingPreoperative comorbidities were dyslipidemia in 52.3%, insulin resistance in 30.7%, arterial hypertension in 24.6%, and type 2 diabetes in 5.5%.20652325
nervous system disorder, Cardiovascular DiseasesDeregulated Nutrient SensingMg deficiency is associated with insulin resistance, cardiovascular disease, and disorders of the nervous system.20653401
Inflammation, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingPatients undergoing continuous ambulatory peritoneal dialysis (CAPD) often have inflammation and dyslipidemia that accelerate to atherosclerosis.20654604
DyslipidemiasDeregulated Nutrient SensingMore attention should be paid to dyslipidemia in the management of the CAPD patients.20654604
Overweight, ObesityDeregulated Nutrient SensingOverweight, obesity, and their associations with insulin resistance and b-cell function among Chinese: a cross-sectional study in China.20655552
Sensorineural Hearing Loss (disorder), Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIdiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias.20658017
Dyslipidemias, Systolic dysfunction, ObesityDeregulated Nutrient SensingThe multivariate analysis for independent predictors of primary end points showed that age (P = .001), gender (P = .02), dyslipidemia (P = .01), obesity (P = .001), and systolic dysfunction (P = .048) represented the significant predictors.20659788
DyslipidemiasDeregulated Nutrient SensingOlder age, increased adiposity, and dyslipidemia were the dominant features of FHD(+) clinical phenotype.20660046
Non-alcoholic Fatty Liver Disease, Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe analysis shows that type II diabetes (DM) and/or insulin resistance (IR) are independent predictors of overall mortality in CH-B, NAFLD and ALD (p <0.05).20660697
Fatty Liver, No metabolic abnormalities, Dyslipidemias, ObesityDeregulated Nutrient SensingMost of these patients have metabolic abnormalities such as obesity, dyslipidemia and fatty liver.20660985
Fatty Liver, DyslipidemiasDeregulated Nutrient SensingShe showed a slight body fat increase, dyslipidemia and fatty liver.20660985
Chronic Lymphocytic LeukemiaDeregulated Nutrient SensingHere, we have analyzed the mechanisms involved in AICAR-induced apoptosis in CLL cells in which it activates its only well-known molecular target, adenosine monophosphate-activated protein kinase (AMPK).20664053
Chronic Lymphocytic LeukemiaDeregulated Nutrient SensingAICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.20664053
Cessation of life, Chronic Lymphocytic LeukemiaDeregulated Nutrient SensingHowever, AMPK activation with phenformin or A-769662 failed to induce apoptosis in CLL cells and AICAR also potently induced apoptosis in B lymphocytes from Ampka1(-/-) mice, demonstrating an AMPK-independent mechanism of cell death.20664053
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTwo of the eight patients had diabetes and one had pre-existing dyslipidaemia.20664584
ObesityDeregulated Nutrient SensingAsian Indians as an ethnic group are at particularly high risk of insulin resistance and central obesity.20666703
ObesityDeregulated Nutrient SensingThere were no statistically significant associations with obesity, metabolic parameters, insulin resistance or any inflammatory cytokines identified.20668471
Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes and insulin resistance in the absence of high BP did not seem to contribute significantly to UAE in this cohort.20668471
Diabetes MellitusDeregulated Nutrient SensingThese findings suggested that insulin resistance and exaggerated glucose fluctuation could be attributable to poor outcomes after AMI in patients with new diabetes.20674993
Glucose Intolerance (disease), Overweight, ObesityDeregulated Nutrient SensingHowever, there was no significant difference in the age-standardised prevalence of glucose intolerance, overweight or obesity.20675005
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingAtherogenic dyslipidemia in patients with established coronary artery disease.20675108
Dyslipidemias, Data types - Address, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPatients with stable coronary heart disease (CHD) and atherogenic dyslipidemia (AD) have a high-risk of recurrence and are those who derive most benefit from treatment with lipid-lowering agents.20675108
DyslipidemiasDeregulated Nutrient SensingLaboratory alterations such as dyslipidemia and increase of hepatic enzymes are reported.20676466
Prediabetes syndrome, Overweight, Dyslipidemias, PrehypertensionDeregulated Nutrient SensingWe found a high prevalence of smoking (18.9%), arterial prehypertension (14.1%) and overweight (11.2%), 9.2% of study participants had prediabetes, and the most frequent dyslipidemia was low HDL cholesterol (13.3%).20676535
ObesityDeregulated Nutrient SensingHigh total fat and SFA intake and a low intake of MUFAs and omega-3 PUFAs showed imbalanced nutrition, which could be responsible for the increasing prevalence of obesity and insulin resistance in urban Asian Indian adolescents and young adults.20679142
ObesityDeregulated Nutrient SensingStudies in obesity have implicated adipocytokines in the development of insulin resistance, which in turn may lead to accelerated aging.20679357
Obesity, Diabetes MellitusDeregulated Nutrient SensingIn this study, we determined associations of chromosomal telomere length (TL) to markers of obesity and insulin resistance in middle-aged adult male and female Arabs with and without diabetes mellitus type 2 (DMT2).20679357
ObesityDeregulated Nutrient SensingObesity and insulin resistance are associated with chromosomal TL among adult Arabs.20679357
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia causes coronary heart disease in middle-aged and elderly adults, but the consequences of lipid exposure during young adulthood are unclear.20679558
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIntensive behavioral treatment was provided, patients with dyslipidemia and diabetes were excluded, and attrition at 2 years was high.20679559
Metabolic Diseases, Dyslipidemias, Endothelial dysfunction, Glycogen Storage DiseaseDeregulated Nutrient SensingThe glycogen storage diseases are a rare form of inherited metabolic disease affecting intracellular glycogen metabolism, and several studies suggest glycogen storage disease (GSD) III predisposes patients to dyslipidemia and endothelial dysfunction.20679683
Inflammation, Endothelial dysfunctionDeregulated Nutrient SensingBiomarkers of inflammation, endothelial dysfunction and insulin resistance in adults of Inner Mongolia, China.20680929
Inflammation, Endothelial dysfunctionDeregulated Nutrient SensingLow-grade chronic inflammation and endothelial dysfunction have been hypothesized to underlie the constellation of cardiometabolic risk factors, possibly by inducing insulin resistance.20680929
Inflammation, Endothelial dysfunctionDeregulated Nutrient SensingThis study suggests that inflammation and endothelial dysfunction may relate to insulin resistance.20680929
Inflammation, Sarcopenia, Malnutrition, Chronic diseaseDeregulated Nutrient SensingThe causes of sarcopenia are multi-factorial and can include disuse, changing hormonal function, chronic diseases, inflammation, insulin resistance, and nutritional deficiencies.20683658
Hepatobiliary Disorder, Metabolic Syndrome XDeregulated Nutrient SensingElevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease.20683957
Prostate Cancer Outcomes Study, HyperandrogenismDeregulated Nutrient SensingWomen with PCOS had higher insulin resistance and hyperandrogenism indices and lower flow-mediated dilation compared with controls.20684955
Prostate Cancer Outcomes Study, HyperandrogenismDeregulated Nutrient SensingBoth insulin sensitizers induced favorable changes in insulin resistance and hyperandrogenism indices in women with PCOS.20684955
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn young women with PCOS, treatment with metformin or pioglitazone for 6 months induces a similar beneficial effect on endothelial function; this may be partially attributed to an improvement in insulin resistance.20684955
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTwo received antihypertensive medications, two had type 2 diabetes and four were treated for dyslipidaemia.20685833
Infertility, Dyslipidemias, ObesityDeregulated Nutrient SensingIncreased cardiovascular risk factors (obesity and dyslipidaemia) and infertility are important sequelae and active identification and treatment are necessary.20685833
Polycystic Ovary SyndromeDeregulated Nutrient SensingLow-dose metformin improves pregnancy rate in in vitro fertilization repeaters without polycystic ovary syndrome: prediction of effectiveness by multiple parameters related to insulin resistance.20687400
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingLow-dose metformin improved pregnancy rate in IVF repeaters without PCOS, probably by decreasing insulin resistance.20687400
Metabolic DiseasesDeregulated Nutrient SensingControlling SIRT1 expression by microRNAs in health and metabolic disease.20689156
Metabolic DiseasesDeregulated Nutrient SensingThe FXR/miR-34a pathway and other miRs controlling SIRT1 may be useful therapeutic targets for age-related diseases, including metabolic disorders.20689156
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingOn average 54% of residents with documented CVD were prescribed aspirin and 31% of those with CVD and/or dyslipidaemia were prescribed statins.20690381
atherosclerotic, Carotid Intima-Media ThicknessDeregulated Nutrient SensingA TRIB3 Q84R gain-of-function polymorphism has been associated with insulin resistance both in vitro and in vivo and with several atherosclerotic phenotypes, including increased carotid intima-media thickness (IMT).20693163
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity.20698957
Obesity, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%.20698957
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHigh prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population.20698957
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Coronary heart diseaseDeregulated Nutrient SensingA randomized trial with 325 patients referred to the centre between 1988 and 1989 for dyslipidemia, hypertension, type 2 diabetes and coronary heart disease; 239 patients were randomized to the programme, 86 randomized to usual care.20700054
Dyslipidemias, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes MellitusDeregulated Nutrient SensingAmong the 710 patients with personal history of cardiovascular disease (CVD) and/or diabetes, 632 (89%) presented with dyslipidaemia, of which 278 (44%) and 134 (21%) patients were treated and adequately controlled, respectively.20700055
Infarction, DyslipidemiasDeregulated Nutrient SensingFurther investigation revealed dyslipidemia, impaired glucose tolerance, and a middle cerebral artery territory infarct.20702115
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individuals.20702522
ObesityDeregulated Nutrient SensingOur results demonstrate that insulin resistance and oxidative stress have a significant impact on the CFU-EC colony formation in obesity.20706205
Glucose Intolerance (disease), Obesity, Diabetes MellitusDeregulated Nutrient SensingPrevalence of obesity, elevated plasma triglyceride, and glucose intolerance was higher among older subjects and subjects both of whose parents had diabetes.20707738
ObesityDeregulated Nutrient SensingMarkers of cholesterol synthesis cluster with clinical and laboratory markers of obesity and insulin resistance.20708389
Alcoholic Intoxication, Chronic, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe various listed risk factors were: dyslipidemia (58.1%), obesity (36.12%), alcoholism (16.7%) and diabetes (10.6%).20708726
Diabetes Mellitus, Non-Insulin-Dependent, Diseases of mitral valveDeregulated Nutrient SensingEffects of chronic elevation of atrial natriuretic peptide and free fatty acid levels in the induction of type 2 diabetes mellitus and insulin resistance in patients with mitral valve disease.20709514
Diseases of mitral valveDeregulated Nutrient SensingThe relationship between atrial natriuretic peptide (ANP), increased free fatty acid (FFA) and insulin resistance in patients with mitral valve disease (MVD), a group characterised by elevated atrial pressure and increased ANP levels, is not defined.20709514
Tumor necrosis, Hyperinsulinism, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIn CHD, insulin resistance and hyperinsulinaemia were present both before and after surgery with increased tumour necrosis factor (TNF)-a and interleukin (IL)-6 levels.20709514
Increased insulin level, Pancreatic carcinomaDeregulated Nutrient SensingSeveral reports have suggested that conditions associated with hyperinsulinemia and insulin resistance, such as diets high in carbohydrates, may influence the risk of pancreatic cancer, although results from prior studies have been mixed.20711806
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia is a risk factor for incident type 2 diabetes; however, no study has specifically assessed the lipid ratios (i.e.20712907
TG geneDeregulated Nutrient SensingScreening programs that could identify insulin resistance early enough for intervention to affect outcome often rely on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels.20715971
seleniumDeregulated Nutrient SensingFor men, AUC-ROC for prediction of insulin resistance by TG/HDL-C was: 0.77 +- 0.01, mean +- standard error (SE), with an optimal cutoff of >=2.5.20715971
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes.20719107
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRecent studies have demonstrated a relationship between insulin resistance (IR) and type 2 diabetes mellitus (T2DM).20720269
Ischemic stroke, ThrombophiliaDeregulated Nutrient SensingThe relationship between insulin resistance and hypercoagulability in acute ischemic stroke.20720426
InfarctionDeregulated Nutrient SensingInsulin resistance has effects on the coagulation system, which is important in the acute phase of infarct.20720426
Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingWe examined the relationships between insulin resistance, hemostatic markers and stroke severity in acute ischemic stroke patients.20720426
Ischemic strokeDeregulated Nutrient SensingProtein C (PC), protein S (PS), fibrinogen, von Willebrand factor and antithrombin III (AT III) were studied in 75 acute ischemic stroke patients with and without insulin resistance.20720426
Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingThe significant associations between insulin resistance and hemostatic markers may be relevant to stroke severity by causing a procoagulant tendency in acute ischemic stroke.20720426
Hyperglycemia, physiopathologicalDeregulated Nutrient SensingPparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.20724579
Increased insulin levelDeregulated Nutrient SensingWe hypothesized that murine Pparg-P465L mutation leads to covert insulin resistance, which is masked by hyperinsulinemia and increased pancreatic islet mass, to retain normal plasma glucose.20724579
HyperglycemiaDeregulated Nutrient SensingPPARg-P465L mutation worsens hyperglycemia in Ins2(Akita/+) mice primarily because of adipose-specific insulin resistance and altered storage function.20724579
Inflammation, Adrenal Gland Hyperfunction, Cardiovascular DiseasesDeregulated Nutrient SensingThe frailty syndrome is associated with inflammation, hypercortisolemia, and cardiovascular diseases, all of which are linked with insulin resistance.20725120
Weight decreasedDeregulated Nutrient SensingOur results suggest that postprandial insulin resistance is higher in frail than in healthy elderly women, and TEF is similar, indicating that both processes do not contribute to the propensity for body weight loss.20725120
Apolipoproteins B, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOverall, 36% of patients had normal LDL cholesterol values but elevated apolipoprotein B. Apolipoprotein B is the most frequently occurring dyslipidaemia in type 2 diabetes.20726197
Apolipoproteins B, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo analyze the pattern of dyslipidaemias including apolipoprotein B in type 2 diabetes.20726197
Liver CirrhosisDeregulated Nutrient SensingInsulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis.20728234
ObesityDeregulated Nutrient SensingObesity is associated with insulin resistance, increased leptin, and decreased adiponectin serum levels.20728234
Cessation of life, Liver Cirrhosis, FAM126A geneDeregulated Nutrient SensingIn patients with compensated HCV cirrhosis, insulin resistance but not serum levels of adiponectin and leptin predicted the occurrence of HCC and of liver-related death or transplantation.20728234
Hypertension, CTCAE, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingThe main preoperative comorbidities were: systemic arterial hypertension (79%), dyslipidemia (48%) and family history of coronary artery disease (38%).20730262
ObesityDeregulated Nutrient SensingIGF-binding protein 2 (IGFBP2) is secreted by white adipocytes and contributes to the prevention of diet-induced obesity and age-related insulin resistance in mice.20730703
ObesityDeregulated Nutrient SensingThe present study was aimed at determining IGFBP2 mRNA levels in adipose tissue in conditions of insulin resistance such as aging and obesity.20730703
DyslipidemiasDeregulated Nutrient SensingDyslipidemia was associated with CAD in males and family history of CAD was a significant risk factor for females with positive CTA findings.20734235
Dyslipidemias, Chronic Kidney Diseases, AtherosclerosisDeregulated Nutrient SensingDyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease.20736985
Proteinuria, DyslipidemiasDeregulated Nutrient SensingLower GFR was associated with higher triglycerides, lower HDL-C, and higher non-HDL-C. Nephrotic-range proteinuria was significantly associated with dyslipidemia and combined dyslipidemia.20736985
DyslipidemiasDeregulated Nutrient SensingCompared with children with a GFR>50, children with a GFR<30 had significantly increased odds ratios for any dyslipidemia or for combined dyslipidemia.20736985
Nephrotic range proteinuria, Dyslipidemias, Chronic Kidney Diseases, ObesityDeregulated Nutrient SensingHence, among children with moderate chronic kidney disease, dyslipidemia is common and is associated with lower GFR, nephrotic proteinuria, and non-renal factors including age and obesity.20736985
Endothelial dysfunctionDeregulated Nutrient SensingDyslipidemias constitute an independent risk factor for the development of atherogenesis and they also predispose to the development of endothelial dysfunction (ED).20737263
ObesityDeregulated Nutrient SensingRelating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period.20738279
ObesityDeregulated Nutrient SensingIncreasing insulin resistance was associated with a shorter time to FMP (P < 0.003) and associations of obesity and time to FMP were observed (P = 0.004, in model with FSH).20738279
Steatohepatitis, Metabolic Diseases, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingLiver steatosis is often found in association with common cardiometabolic disorders, conditions that may all occur in a shared context of abdominal obesity and dyslipidemia.20738844
Hypermetabolism, Malignant neoplasm of gastrointestinal tractDeregulated Nutrient SensingThe metabolic response to gastrointestinal cancer in patients undergoing surgery is associated with hypermetabolism and insulin resistance.20739147
Obesity, diabeticDeregulated Nutrient SensingCorrelation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients.20739208
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingHowever, it may be that resistin plays a role in the pathogenesis of obesity and insulin resistance, both of which could, indirectly, contribute to the development of type 2 diabetes.20739208
Alzheimers DiseaseDeregulated Nutrient SensingInsulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study.20739649
Increased insulin level, HyperglycemiaDeregulated Nutrient SensingThe results of this study suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate NP formation in combination with the effects of APOE epsilon4.20739649
Thyroid dysfunctionDeregulated Nutrient SensingAssociations between cardiovascular risk, insulin resistance, beta-cell function and thyroid dysfunction: a cross-sectional study in She ethnic minority group of Fujian Province in China.20798227
Thyroid dysfunctionDeregulated Nutrient SensingTo investigate the associations between cardiovascular risk, insulin resistance (IR), b-cell function and thyroid dysfunction in She ethnic minority group in China.20798227
Inflammation, Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, ObesityDeregulated Nutrient SensingExcess secretion of various adipocyte-derived molecules has been linked with insulin resistance, obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease.20798476
Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidaemia (62% vs. 56%; p <0.001), history of CAD (39% vs. 35%; p = 0.023) and obesity (BMI >30 kg/m2 [23% vs. 19%; p = 0.003]) were more frequent in group 1 who were admitted longer after symptom onset (280 min vs. 230 min).20799102
HypoglycemiaDeregulated Nutrient SensingInsulin antibody (IAb) may be produced in patients receiving long-term, animal-derived insulin, leading to insulin resistance or hypoglycemia.20799766
Critical IllnessDeregulated Nutrient SensingImpact of glucocorticoids on insulin resistance in the critically ill. Glucocorticoids (GCs) have been shown to reduce insulin sensitivity in healthy individuals.20801543
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingN-3 fatty acids have several beneficial effects on dyslipidemia and diabetes, conditions which are prevalent in the elderly.20803425
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingDisposition index, glucose effectiveness, and conversion to type 2 diabetes: the Insulin Resistance Atherosclerosis Study (IRAS).20805282
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn a cross-sectional study we studied the fasting serum DPP-4 enzymatic activity (sDPP-4) and the insulin resistance index (HOMA2-IR) in gliptin naive patients with type 2 diabetes and in non-alcoholic fatty liver disease (NAFLD) and in healthy controls (CNTRL).20805868
Weight Gain, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTreatment with antipsychotics can be associated with weight gain, and second-generation (atypical) antipsychotics (SGAs) can increase the risk for diabetes and dyslipidemia.20807065
Inflammation, Diabetes MellitusDeregulated Nutrient SensingMagnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes.20807870
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingDysglycemia was associated with hypertension, dyslipidemia, and older age.20808110
Colorectal CarcinomaDeregulated Nutrient SensingPrognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.20808308
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingAMP-activated protein kinase activation is cytotoxic to cancer cells, supporting AMPK as a tumour suppressor and a potential therapeutic target.20808308
Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingAmong 718 colon and rectal cancers, phosphorylated AMPK (p-AMPK) and p-MAPK3/1 expression was detected in 409 and 202 tumours, respectively, by immunohistochemistry.20808308
Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingPhosphorylated AMPK expression in colorectal cancer is associated with superior prognosis among p-MAPK3/1-positive cases, but not among p-MAPK3/1-negative cases, suggesting a possible interaction between the AMPK and MAPK pathways influencing tumour behaviour.20808308
Hyperglycemia, Dyslipidemias, ETV3 wt AlleleDeregulated Nutrient SensingOur findings emphasize the importance of MetS screening and managing dyslipidemia and hyperglycemia in older persons in general practice.20810578
Hepatitis C, Depression, CTCAEDeregulated Nutrient SensingIn addition to literature data on KYN/TRY ratio (IDO activity index), we observe neopterin levels (index of activity of rate-limiting enzyme of guanine-BH4 pathway) to be higher in carriers of high (T) than of low (A) producers alleles; and to correlate with AAMPD markers (e.g., insulin resistance, body mass index, mortality risk), and with IFN-alpha-induced depression in hepatitis C patients.20811799
SLC25A20 gene, DyslipidemiasDeregulated Nutrient SensingIn contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance.20814018
ObesityDeregulated Nutrient SensingIndividuals with insulin resistance (IR) usually have upper body obesity phenotype, often accompanied by an increase in plasma free fatty acids (FFA).20815161
Non-insulin HypoglycemicDeregulated Nutrient SensingEighteen individuals presented insulin resistance (HOMA-IR > 2.7) and 29 were non-insulin resistant (non-IR).20815161
DyslipidemiasDeregulated Nutrient SensingThis effect increased after adjustment for gender, serum creatinine and known dyslipidaemia (OR27.61; 95% CI 6.41-119.04).20815655
DyslipidemiasDeregulated Nutrient SensingTo determine the prevalence of and risk factors for dyslipidemia in Shanghai.20817022
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia increased with age, with the peak prevalence (43%) occurring after age 55.20817022
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThere is a high prevalence of dyslipidemia, mainly hypertriglyceridemia and low HDL-C, in Shanghai.20817022
Inflammation, Periodontal Diseases, AtherosclerosisDeregulated Nutrient SensingThe candidates contributing to atherosclerosis in periodontal disease include low-grade inflammation such as C-reactive protein (CRP) and insulin resistance.20817211
Inflammation, Periodontal DiseasesDeregulated Nutrient SensingA previous study demonstrated that periodontal therapy leads to an improvement in CRP as well as insulin resistance, indicating the relationship between periodontal disease and low-grade inflammation or insulin resistance.20817211
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidaemia is a major risk factor for coronary heart disease.20817685
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, insulin resistance was less severe in elderly-onset diabetes than in usual-onset diabetes.20819452
Atrial Fibrillation by ECG Finding, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cerebrovascular accidentDeregulated Nutrient SensingPatients with atrial fibrillation, previous myocardial infarction, diabetes mellitus, dyslipidemia, tobacco use, and no or irregular use of anti-platelet medications were at higher risk for recurrent stroke.20819503
Malnutrition, Dyslipidemias, Cerebrovascular accident, Heart failure, ComorbidityDeregulated Nutrient SensingPatients who did not survive were significantly older, with lower cognitive and functional performance, with diminished visual acuity, higher comorbidity, high risk of malnutrition, higher number of drugs taken and a higher percentage of patients with the diagnosis of dyslipidaemia, heart failure or previous stroke.20823123
diabeticDeregulated Nutrient SensingEffects of telmisartan on insulin resistance in Japanese type 2 diabetic patients.20823643
diabeticDeregulated Nutrient SensingPPARgamma agonists are widely used in type 2 diabetic patients to reduce insulin resistance.20823643
Structure of beta Cell of isletDeregulated Nutrient SensingIn addition to improving insulin resistance and pancreatic b-cell dysfunction, the GLP-1 agonists and DPP-4 inhibitors improve the impaired incretin response, as well as increase insulin secretion and reduce glucagon secretion, both in a glucose-dependent manner.20824239
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingOur objective was to elucidate the specific roles of obesity, type 2 diabetes mellitus, insulin-resistance and abdominal fat distribution.20825466
Ndonga languageDeregulated Nutrient SensingDO and NDO subjects had similar whole-body insulin resistance, BMI and waist circumference, higher than those of C subjects (P < 0*001).20825466
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingType 2 diabetes is associated with increased fat accumulation in the liver, independent of obesity and whole-body insulin resistance.20825466
Hyperglycemia, Critical IllnessDeregulated Nutrient SensingHyperglycemia and insulin resistance frequently occur in critically ill and in morbidly obese (MO) patients.20825686
Critical IllnessDeregulated Nutrient SensingAs in MO patients, increased levels of proinflammatory cytokines and altered levels of adipokines may contribute to the development of insulin resistance in critically ill patients.20825686
Chronic heart failureDeregulated Nutrient SensingAddition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without b-blockers.20827028
Chronic heart failure, Congestive heart failureDeregulated Nutrient SensingAngiotensin II and insulin resistance (IR) have clinical implications in the pathophysiology of chronic heart failure (CHF).20827028
ObesityDeregulated Nutrient SensingSerum resistin concentrations are higher in human obesity but independent from insulin resistance.20827661
ObesityDeregulated Nutrient SensingThe b(2)-adrenergic receptor (ADRB2) mediates obesity, cardiorespiratory fitness, and insulin resistance.20829805
DyslipidemiasDeregulated Nutrient SensingDiverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias.20831628
DyslipidemiasDeregulated Nutrient SensingPrevious studies have suggested a link between circulating levels of 25-hydroxyvitamin D (25-D) and dyslipidaemias.20831628
OverweightDeregulated Nutrient SensingMultiple regression analysis showed that serum osteocalcin levels were associated with VFA in obese and overweight men after adjustment for age, insulin resistance, current smoking, alcohol consumption and adiposity indices.20831864
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.20837822
palladium, "Alzheimers Disease", Data types - Address, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a causal factor in prediabetes (PD) and type 2 diabetes (T2D) and increases the risk of developing Alzheimer disease (AD).20837822
Impaired cognition, Data types - AddressDeregulated Nutrient SensingInsulin resistance may be a marker of AD risk that is associated with reduced CMRglu and subtle cognitive impairments at the earliest stage of disease, even before the onset of mild cognitive impairment.20837822
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe significant genes were tested in a logistic regression model controlling for age, hypertension, and dyslipidemia.20837969
Glucose Intolerance (disease), Complication AspectsDeregulated Nutrient SensingConcomitant preservation of pancreaticoduodenal complex eliminated risks of biliary complications and glucose intolerance.20844978
Alzheimers Disease", Glucose Intolerance (disease)Deregulated Nutrient SensingAerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease.20847403
Acanthosis Nigricans, SteatohepatitisDeregulated Nutrient SensingNormal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis: evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence.20847546
ObesityDeregulated Nutrient SensingA major factor in the development of insulin resistance is obesity.20847546
Acanthosis Nigricans, SteatohepatitisDeregulated Nutrient SensingThis case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence.20847546
Diabetes MellitusDeregulated Nutrient SensingThe CLU gene was associated with diabetes, probably through an increase in insulin resistance primarily and through an impairment of insulin secretion secondarily.20850846
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingOptimal pharmacologic approach to patients with hypertriglyceridemia and low high-density lipoprotein-cholesterol: randomized comparison of fenofibrate 160 mg and niacin 1500 mg. Atherogenic dyslipidemia is emerging as a target of lipid-modifying therapy.20855072
DyslipidemiasDeregulated Nutrient SensingOur results underscore more individualized pharmacologic approaches to patients with atherogenic dyslipidemia.20855072
Diabetes MellitusDeregulated Nutrient SensingData were adjusted for BMI, insulin resistance, and duration of diabetes.20855551
Peripheral Vascular Diseases, Dyslipidemias, Heart failure, Diabetes MellitusDeregulated Nutrient SensingThe development of an episode of IC was independently associated with diabetes, dyslipidemia, presence of heart failure, peripheral arterial disease and treatment with digoxin or ASA.20857527
DyslipidemiasDeregulated Nutrient SensingIncreased very-low-density lipoprotein triglycerides (VLDL-TG) concentration is a central feature of diabetic dyslipidemia.20858686
Prostate Cancer Outcomes StudyDeregulated Nutrient Sensing[Effects of bushen tongmai recipe on expression of phosphatidylinositol-3-kinase in PCOS rats accompanying with insulin resistance].20862969
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingTo observe the effects of bushen tongmai recipe (BSTMR) on mRNA and protein expressions of phosphatidylinositol-3-kinase (PI-3K) p85alpha in hepatic, adipose, muscular and ovarian tissues in PCOS rats with insulin resistance (IR).20862969
Endoribonuclease ZC3H12ADeregulated Nutrient SensingA significant difference (p < 0.05) between the 2 groups was found in the treatment-induced changes in fasting insulin, the insulin resistance index HOMA, HDL cholesterol, triglycerides, diastolic blood pressure (all in favor of pioglitazone) and in body weight (increase with pioglitazone).20863381
Heart failure, Diabetes MellitusDeregulated Nutrient SensingHeart failure (HF) is associated with increased insulin resistance, but the consequences of HF for development of diabetes are not well studied.20864482
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia of mothers with familial hypercholesterolemia deteriorates lipids in adult offspring.20864670
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, HypopituitarismDeregulated Nutrient SensingBecause metabolic syndrome, including insulin resistance, is the main pathogenesis of the development of nonalcoholic fatty liver disease (NAFLD), we considered that patients diagnosed with hypopituitarism have an increased risk of developing NAFLD.20865648
Critical Illness, ObesityDeregulated Nutrient SensingAdiponectin has been proposed as an important regulator of glucose metabolism influencing obesity and insulin resistance, which are important risk factors for the outcome of critically ill patients.20869198
Non-alcoholic Fatty Liver Disease, Obesity, Fatty infiltrationDeregulated Nutrient SensingObesity and insulin resistance cause fatty infiltration of many organs, including the pancreas (pancreatic steatosis [PS]) and the liver (nonalcoholic fatty liver disease [NAFLD]).20871475
Inflammation, Critical Illness, HyperglycemiaDeregulated Nutrient SensingWe investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness.20871818
Seizures, Dyslipidemias, Cerebral HemorrhageDeregulated Nutrient SensingThe associated factors of post-stroke seizures were non-dyslipidemia (p = 0.0007), intracerebral hemorrhage (p = 0.015), and lesions at cortical area (p = 0.05).20873075
Carcinogenesis, Mass in breastDeregulated Nutrient SensingInsulin resistance and breast carcinogenesis: a cross-sectional study among Iranian women with breast mass.20874423
Breast Carcinoma, Carcinogenesis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDespite existing epidemiologic data concerning the increased incidence of breast cancer in diabetes type 2, the association between insulin resistance and breast carcinogenesis is not yet well defined.20874423
Carcinogenesis, Breast CarcinomaDeregulated Nutrient SensingWe conclude that the noted linkage between insulin resistance and breast cancer may indicate an underlying pathology of mammary carcinogenesis.20874423
Atrial Fibrillation by ECG Finding, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Peripheral Vascular Diseases, Carotid Stenosis, Hypertension, CTCAEDeregulated Nutrient SensingCharacteristics associated with in-hospital mortality were age, arrival mode (eg, via ambulance versus other mode), history of atrial fibrillation, previous stroke, previous myocardial infarction, carotid stenosis, diabetes mellitus, peripheral vascular disease, hypertension, history of dyslipidemia, current smoking, and weekend or night admission.20876438
glucose metabolismDeregulated Nutrient SensingThe significant correlation between GGT and acute glucose dysmetabolism (as indicated by admission glycemia and insulin-resistance) can account, at least in part, for the prognostic role of GGT.20878500
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Beta-Cell Function MeasurementDeregulated Nutrient SensingEarly onset type 2 diabetes mellitus (T2DM) is associated with obesity, insulin resistance and impaired beta-cell function.20880682
Non-alcoholic Fatty Liver Disease, Beta-Cell Function MeasurementDeregulated Nutrient SensingNAFLD was present in 41% of our obese children and was associated with higher insulin resistance, but not with impaired beta-cell function.20880682
Hypertension, CTCAE, Overweight, Diabetes MellitusDeregulated Nutrient SensingTelmisartan effects on insulin resistance in obese or overweight adults without diabetes or hypertension.20883237
Cardiovascular morbidity, Dyslipidemias, Kidney FailureDeregulated Nutrient SensingPatients with dyslipidemia and advanced renal failure are at markedly increased risk of cardiovascular morbidity and mortality.20885068
OverweightDeregulated Nutrient SensingInsulin resistance and self-perceived scholastic competence in inner-city, overweight and obese, African American children.20887741
Congestive heart failureDeregulated Nutrient SensingTestosterone supplementation improves functional capacity, insulin resistance, and muscle strength in women with advanced CHF.20888520
Inflammation, Disease, AtherosclerosisDeregulated Nutrient SensingFatty acid-binding proteins (FABPs) 4 and 5 play coordinated roles in rodent models of inflammation, insulin resistance, and atherosclerosis, but little is known of their role in human disease.20920650
Postoperative Complications, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNAFLD and insulin resistance do not increase the risk of postoperative complications among patients undergoing bariatric surgery--a prospective analysis.20922498
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) and insulin resistance are common consequences of obesity and are highly prevalent among patients undergoing bariatric surgery.20922498
Postoperative Complications, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and NAFLD have been reported to be associated with postoperative complications following major surgery.20922498
Inflammation, Chronic pain, ObesityDeregulated Nutrient SensingAfter adjustment for insulin resistance, inflammation, and pain-related comorbidities, central obesity predicted higher TPI scores (OR 1.55, 95% CI 1.04-2.33) and nearly doubled the risk of chronic pain (OR 1.70, 95% CI 1.05-2.75).20926190
Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingNon-khat chewers were more likely to have diabetes mellitus, hypertension, dyslipidemia, obesity, and prior history of coronary artery disease and revascularization.20926835
Diabetes MellitusDeregulated Nutrient SensingSerum levels of retinol-binding protein 4 (RBP4) are associated with insulin resistance and type 2 diabetes mellitus (T2DM) and may impact on b-cell function.20929509
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingD2 Thr92Ala and PPARg2 Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients.20930717
Sepsis, HyperglycemiaDeregulated Nutrient SensingHyperglycemia and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis.20932285
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingRetinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes.20932285
Liver functionDeregulated Nutrient SensingThe strong associations with hepatic and renal function, insulin resistance and acute mortality collectively suggest a role of RBP4 in the pathogenesis of critical illness, possibly as a negative acute phase reactant, and allow a proposition as a potential novel biomarker for ICU patients.20932285
DyslipidemiasDeregulated Nutrient SensingRecent evidence has also suggested that a calcium-rich diet may have beneficial effects on insulin resistance and dyslipidemia.20934855
Tumor necrosis, Sleep Apnea, ObstructiveDeregulated Nutrient SensingAssociation of osteopontin and tumor necrosis factor-a levels with insulin resistance in obese patients with obstructive sleep apnea syndrome.20935448
Ischemic strokeDeregulated Nutrient SensingInsulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study.20937946
Ischemic strokeDeregulated Nutrient SensingWhether insulin resistance predicts ischemic stroke (IS) is still a matter of debate.20937946
Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingTo determine the association between insulin resistance (IR) and risk of first ischemic stroke in a large, multiethnic, stroke-free cohort without diabetes.20937946
Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance estimated using the HOMA is a marker of increased risk of incident stroke in nondiabetic individuals.20937946
Fatty Liver, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingPolymorphisms in the gene encoding adiponectin receptor 1 (AdipoR1) are associated with insulin resistance, fatty liver, increased risk for type 2 diabetes and cardiovascular disease.20938443
Structure of posterior cerebral arteryDeregulated Nutrient SensingHowever, the oncogenic contributions downstream of the PI3K pathway made by mammalian target of rapamycin complex 1 (mTORC1)-mediated cell growth signal transduction in PCa have yet to be elucidated in detail.20940396
Tuberous SclerosisDeregulated Nutrient SensingHere, we engineered constitutive mTORC1 activation in prostate epithelium by a conditional genetic deletion of tuberous sclerosis complex 1 (Tsc1), a potent negative regulator of mTORC1 signaling.20940396
DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia is high and increases even in younger people.20942934
Dyslipidemias, AbnormalDeregulated Nutrient SensingPatients with short duration of dyslipidemia were mainly characterized by relatively young age, occupational groups, not eating or irregular eating breakfast, less physical activities, having the habit of smoking, and 53.8% is with abnormal LDL-c, 10.4% is with abnormal HDL-c, and 51.5% is with abnormal TG.20942934
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is highly prevalent in Asian Indians and contributes to worldwide public health problems, including diabetes and related disorders.20943755
Cardiac DeathDeregulated Nutrient SensingStepwise Cox hazard analysis associated cardiac death with reduced BMIPP uptake and increased insulin resistance.20944544
Cardiac Death, Coronary Artery DiseaseDeregulated Nutrient SensingThus, impaired myocardial fatty acid metabolism and insulin resistance may be associated with cardiac death among hemodialysis patients without obstructive coronary artery disease.20944544
DyslipidemiasDeregulated Nutrient SensingThe occurrence of dyslipidemia is increasing in pediatric populations.20944894
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingThe majority of the population was dyslipidemic (63.8%; 95%CI: 59.3 - 68.2), with hypoalphalipoproteinemia being the most prevalent dyslipidemia (56%; 95%CI: 51.3 - 60.5).20944894
Inflammation, Sleep Apnea, ObstructiveDeregulated Nutrient SensingThe mechanisms by which OSAS can affect the cardiovascular system are multiple, including the activation of the sympathetic nervous system, systemic inflammation, insulin resistance, and oxidative stress.20944980
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance and vitamin D deficiency in patients with chronic kidney disease stage 2-3.20945958
Chronic Kidney DiseasesDeregulated Nutrient SensingVitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3.20945958
Chronic Kidney DiseasesDeregulated Nutrient SensingOur results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.20945958
AHSG protein, human, Vascular calcificationDeregulated Nutrient SensingFetuin-A has been associated with insulin resistance and inversely related with vascular calcification.20946008
AtherosclerosisDeregulated Nutrient SensingSerum fetuin-A concentration was not associated with measures of insulin resistance or with preclinical atherosclerosis in Hispanics and NHW.20946008
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingThese data indicate that the disparity in prevalence of insulin resistance, type 2 diabetes, and subclinical atherosclerosis between Hispanics and NHW does not appear attributable to differences in fetuin-A concentrations.20946008
CaviaDeregulated Nutrient SensingReduced oxidative stress and improved insulin resistance may contribute to the improvement of CAVI by glimerpiride.20946343
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingImpaired glucose tolerance, insulin resistance, dyslipidemia, and microalbuminuria are common among young adults with HIV.20947103
Diabetes MellitusDeregulated Nutrient SensingOther advantages are the low frequency of flushing, which improved adherence to treatment, and no worsening of insulin resistance in patients with or without diabetes mellitus.20948500
DyslipidemiasDeregulated Nutrient SensingEffects of low-dose of niacin associated to simvastatin in the treatment of mixed dyslipidemia Salgad.20948500
Dyslipidemias, Coronary heart disease, Diabetes Mellitus, Anemia, Hypertension, CTCAEDeregulated Nutrient SensingArterial hypertension (48.6%), anemia (22.9%), coronary disease (19.4%), dyslipidemia (17.3%) and diabetes (16.6%) were the main risk factors.20949226
Congenital AbnormalityDeregulated Nutrient SensingInsulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study.20950415
Left ventricular diastolic dysfunction, Heart failure, Diabetic Cardiomyopathies, Diabetes Mellitus, Non-Insulin-Dependent, Bortezomib/Dexamethasone/Pegylated Liposomal Doxorubicin RegimenDeregulated Nutrient SensingLeft ventricular diastolic dysfunction (LVDD) is considered a precursor of diabetic cardiomyopathy, while insulin resistance (IR) is a precursor of type 2 diabetes mellitus (T2DM) and independently predicts heart failure (HF).20950415
Inflammation, AtherosclerosisDeregulated Nutrient SensingResistin is an adipocytokine involved in insulin resistance, inflammation, and atherosclerosis.20951381
diabeticDeregulated Nutrient SensingSerum profiles of lipids and/or liver enzymes are established markers for the estimation of insulin resistance and diabetic risk in the non-diabetic middle-aged population.20953067
TG gene, DyslipidemiasDeregulated Nutrient SensingPatients with mixed dyslipidemia characterized by elevated low-density lipoprotein cholesterol (LDL-C), elevated triglycerides (TG), and reduced high-density lipoprotein cholesterol (HDL-C) often require combination therapy to improve multiple lipid and nonlipid parameters.20953684
Kidney FailureDeregulated Nutrient SensingHabitual coffee users have risk protection to higher RRI; lower serum albumin, insulin resistance, and renal insufficiency are associated with greater RRI.20954972
Erectile dysfunctionDeregulated Nutrient Sensing* BMI was a significant predictor of decreased libido, impotence and a PAS-SFI score <9, while diabetes/glucose intolerance was a significant predictor of sexual inactivity, impotence and a PAS-SFI score <9.20955266
Sexual Dysfunction, Charge Type Reason - IntoleranceDeregulated Nutrient Sensing* Age, IPSS, BMI and diabetes/glucose intolerance, but not serum testosterone or TPV, were significant independent predictors of sexual dysfunction in the REDUCE study population.20955266
Weight decreasedDeregulated Nutrient SensingDuration of the follow-up and extent of weight loss were similar among the three groups, as were fasting and glucose-stimulated insulin and indices of insulin resistance.20956435
Alzheimers Disease", TauopathiesDeregulated Nutrient SensingAMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies.20957377
Supranuclear paralysis, "Alzheimers Disease", Corticobasal degeneration, Data types - Address, Parkinsonian Disorders, Tauopathies, Brain Diseases, cannabidiol, Frontotemporal dementiaDeregulated Nutrient SensingHere, we show that activated AMPK (p-AMPK) is abnormally accumulated in cerebral neurons in 3R+4R and 3R tauopathies, such as Alzheimer's disease (AD), tangle-predominant dementia, Guam Parkinson dementia complex, Pick's disease, and frontotemporal dementia with parkinsonism linked to chromosome 17, and to a lesser extent in some neuronal and glial populations in the 4R tauopathies, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease.20957377
Data types - AddressDeregulated Nutrient SensingIn AD brains, p-AMPK accumulation decorated neuropil threads and dystrophic neurites surrounding amyloid plaques, and appeared in more than 90% of neurons bearing pre-tangles and tangles.20957377
TauopathiesDeregulated Nutrient SensingGranular p-AMPK immunoreactivity was also observed in several tauopathies in apparently unaffected neurons devoid of tau inclusion, suggesting that AMPK activation preceded tau accumulation.20957377
TauopathiesDeregulated Nutrient SensingThus, activated AMPK abnormally accumulated in tangle- and pre-tangle-bearing neurons in all major tauopathies.20957377
Tauopathies, Nerve DegenerationDeregulated Nutrient SensingBy controlling tau phosphorylation, AMPK might regulate neurodegeneration and therefore could represent a novel common determinant in tauopathies.20957377
TG gene, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingCoronary heart disease risk increases with advancing age and is further increased in patients with mixed dyslipidemia, characterized by elevated low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C), and high triglycerides (TG).20960535
DyslipidemiasDeregulated Nutrient SensingThe combination of rosuvastatin and fenofibric acid (R + FA) results in more comprehensive lipid improvements than corresponding-dose monotherapies, without additional safety concerns, in elderly patients with mixed dyslipidemia.20960535
Polycystic Kidney, Autosomal Dominant, Diabetes MellitusDeregulated Nutrient SensingThe aim of the study was to estimate the pancreatic beta cell function and insulin resistance indexes in a group of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with normal kidney function and no previous diabetes mellitus diagnosis.20961181
Alzheimers Disease", AtherosclerosisDeregulated Nutrient SensingThis inflammatory status, which has been referred to by the neologism "inflammaging", is of sufficient magnitude to impact health and survival time, and correlates with age-related diseases such as atherosclerosis, insulin resistance and Alzheimer's disease.20961694
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNutrient intake in Italian obese patients: relationships with insulin resistance and markers of non-alcoholic fatty liver disease.20961734
Fibrosis AssessmentDeregulated Nutrient SensingWe investigated the prevalence of insulin resistance, elevated liver enzymes, and Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS) in obese and severely obese patients.20961734
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingComparison of lymphomononuclear cell energy metabolism between healthy, impaired glucose intolerance and type 2 diabetes mellitus patients.20963562
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLinear regression analyses adjusted for sex, awakening time, workday, smoking, blood pressure, BMI, diabetes mellitus, and dyslipidemia showed that older age was associated with a blunted cortisol awakening response.20963575
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThe investigated obesity-related cardiovascular risk factors were hyperglycemia, dyslipidemia, and elevated blood pressure.20964583
Diabetes MellitusDeregulated Nutrient SensingHigh polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio without affecting weight, inflammatory markers, insulin resistance or glycaemic control.20968113
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe study subgroups consisted of patients with hypertension (amlodipine) or dyslipidemia (simvastatin).20970220
Hypomagnesemia, Diabetes MellitusDeregulated Nutrient SensingHypomagnesemia, a frequent disorder in renal transplant patients related to the use of calcineurin inhibitors (CNIs), plays a causal role in insulin resistance and type 2 diabetes.20970568
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRisk factors included hypertension (95.8%), dyslipidemia (56.5%), smoking (53.4%), and diabetes (27.2%).20970625
glycationDeregulated Nutrient SensingInsulin resistance is an independent correlate of high serum levels of advanced glycation end products (AGEs) and low testosterone in non-diabetic men.20972372
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOne hundred thirteen non-diabetic men who did not receive any drugs for hypertension and dyslipidemia underwent a complete history and physical examination, determination of blood chemistries, including serum AGEs and testosterone.20972372
Negative Regulation of Cell CycleDeregulated Nutrient SensingOur results show that a decrease in SIRT1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis.20972827
Central neuroblastomaDeregulated Nutrient SensingResveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1.20972827
Steatohepatitis, Hypertriglyceridemia, Diabetes MellitusDeregulated Nutrient SensingShe lacked insulin resistance, hypertriglyceridemia, hepatic steatosis, and diabetes.20979188
Primary malignant neoplasmDeregulated Nutrient SensingThe AMP-activated protein kinase (AMPK) pathway is a master regulator in energy metabolism and may be related to cancer.20980414
Increased insulin level, Prediabetes syndromeDeregulated Nutrient SensingA low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans.20980494
Increased insulin level, Weight decreasedDeregulated Nutrient SensingAlthough lifestyle-induced weight loss improves insulin resistance in prediabetic individuals, postprandial hyperinsulinemia is reduced only when a low-GI diet is consumed.20980494
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity is associated with hypertension, dyslipidemia, and diabetes, but it is also an independent cardiovascular risk factor.21029823
Dyslipidemias, OverweightDeregulated Nutrient Sensing[Prevalence and awareness of dyslipidemia among overweight and obese population in Beijing community].21033142
Dyslipidemias, OverweightDeregulated Nutrient SensingTo investigate the prevalence and percentage of dyslipidemia awareness among overweight and obese residents in Beijing community.21033142
DyslipidemiasDeregulated Nutrient Sensing(2) Prevalence of dyslipidemia increased in proportion with increase of BMI.21033142
Dyslipidemias, OverweightDeregulated Nutrient SensingThe age-standardized prevalence of dyslipidemia of normal, overweight and obese population was 23.21033142
Dyslipidemias, OverweightDeregulated Nutrient Sensing(3) Unexpectedly, the percentage of dyslipidemia awareness in overweight and obese population was not significantly higher than in the normal body weight group (P > 0.05).21033142
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia was high while the percentage of dyslipidemia awareness was rather low in obese population.21033142
Alzheimers DiseaseDeregulated Nutrient Sensing[Analysis of correlation between insulin resistance, blood lipids and Alzheimer's disease].21033433
Alzheimers DiseaseDeregulated Nutrient SensingThese suggested that high blood lipids and insulin resistance were probable risk factors of Alzheimer's disease.21033433
InflammationDeregulated Nutrient SensingDecreased high-density lipoprotein cholesterol is associated with inflammation and insulin resistance in non-diabetic haemodialysis patients.21040164
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance explains the relationship between novel cardiovascular risk factors and hypertension.21042046
Hypertension, CTCAEDeregulated Nutrient SensingTo examine the association between hypertension and new cardiovascular risk factors when considering both classical risk factors and insulin resistance.21042046
Refractory anemias, Rheumatoid Arthritis, Atherosclerosis, Chronic inflammatory disorderDeregulated Nutrient SensingThe risks of insulin resistance and accelerated atherosclerosis are increased in chronic inflammatory diseases including rheumatoid arthritis (RA).21044750
Inflammation, AtherosclerosisDeregulated Nutrient SensingAdipo-(cyto)kines are associated with insulin resistance, atherosclerosis and inflammation.21044750
Depressive disorderDeregulated Nutrient SensingMajor depressive disorder and insulin resistance in nondiabetic young adults in the United States: the National Health and Nutrition Examination Survey, 1999-2002.21044969
Depression, CTCAEDeregulated Nutrient SensingThe association between depression and insulin resistance has been evaluated in previous studies with conflicting results.21044969
Minimal Disseminated DiseaseDeregulated Nutrient SensingUsing logistic regression, no significant association was found between MDD and insulin resistance among the nondiabetic young adults in bivariate analysis (b = -0.01, OR = 0.99, 95% CI = [0.38, 2.57], p = .98).21044969
Minimal Disseminated DiseaseDeregulated Nutrient SensingNo significant association between MDD and insulin resistance among women was found (b = 0.61, OR = 1.84, 95% CI = [0.47, 7.14], p = .38).21044969
Minimal Disseminated DiseaseDeregulated Nutrient SensingOverall findings suggest there is no significant association between MDD and insulin resistance among nondiabetic young adults aged 20-39 years.21044969
East Frisian Low Saxon LanguageDeregulated Nutrient SensingIn addition, triglycerides, fasting insulin, body mass index, LDL-C, hemoglobin A1c, and insulin resistance were significantly associated with FRS.21045711
AtherosclerosisDeregulated Nutrient SensingThe study population included 954 multi-ethnic non-diabetic adults from the Insulin Resistance Atherosclerosis Study (IRAS).21046357
Hypertriglyceridemia, ETV3 wt Allele, Hyperuricemia, ObesityDeregulated Nutrient SensingLogistic regression analysis showed that the obesity, hypertriglyceridemia, MetS and insulin resistance were independent determinants of hyperuricemia in women.21046418
Metabolic acidosis, Diabetes MellitusDeregulated Nutrient SensingChronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes.21046483
Arterial StiffnessDeregulated Nutrient SensingArterial stiffness is strongly associated with insulin resistance in Chinese--a population-based study (Taichung Community Health Study, TCHS).21048381
Arterial StiffnessDeregulated Nutrient SensingFew studies have investigated the association between insulin resistance and arterial stiffness in Chinese.21048381
Arterial StiffnessDeregulated Nutrient SensingArterial stiffness is independently associated with insulin resistance in Chinese middle-aged adults.21048381
Pancreatic Ductal AdenocarcinomaDeregulated Nutrient SensingMechanisms for skeletal muscle insulin resistance in patients with pancreatic ductal adenocarcinoma.21050717
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Glucose Intolerance (disease), Weight decreased, Pancreatic Ductal AdenocarcinomaDeregulated Nutrient SensingWeight loss, glucose intolerance, and insulin resistance are seen in patients with pancreatic ductal adenocarcinoma (PDAC).21050717
NeoplasmsDeregulated Nutrient SensingPeripheral insulin resistance is decreased after tumor resection in patients with PDAC, which is consistent with the hypothesis that factors from the tumor may induce skeletal muscle insulin resistance.21050717
Weight decreasedDeregulated Nutrient SensingIn patients with PDAC, muscle insulin resistance is an early and specific finding unrelated to weight loss, plasma free fatty acid levels, and energy status of the cell.21050717
Claudication (finding)Deregulated Nutrient SensingInsulin resistance is associated with PAD and may contribute to claudication by impairing skeletal muscle metabolism.21051665
Intermittent ClaudicationDeregulated Nutrient SensingFuture studies are required to assess whether calf muscle insulin resistance contributes to exercise limitation in patients with intermittent claudication.21051665
Albuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn obese patients with type 2 diabetes, there is an inverse association between adiponectin and low-grade albuminuria, the association being independent of insulin resistance.21051904
Neuropathy, Dyslipidemias, Coronary heart disease, Retinal Diseases, Kidney Diseases, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia was observed in 78.4%, hypertension in 64.8%, nephropathy in 28.6%, retinopathy in 32.6%, neuropathy in 34.6%, and coronary heart disease in 13%.21052999
Non-alcoholic Fatty Liver Disease, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and diabetes mellitus (DM) are known to contribute to the progression of non-alcoholic fatty liver disease (NAFLD).21054523
Fatty degenerationDeregulated Nutrient SensingTransaminase activities, g-glutamyl-transpeptidase, serum ferritin levels, homeostasis model assessment of insulin resistance index, and substitutions of amino acid 70 were significantly associated with the presence of steatosis, upon univariate analysis.21054524
Steatohepatitis, Glucose Intolerance (disease), Hepatitis CDeregulated Nutrient SensingThe hepatitis C virus (HCV) core protein induces hepatic steatosis and glucose intolerance in transgenic mice.21054524
Glucose Intolerance (disease), Fatty degenerationDeregulated Nutrient SensingGlucose intolerance was more prevalent in patients with steatosis (63%) than in those without steatosis (32%, P = 0.012).21054524
Steatohepatitis, Glucose Intolerance (disease), Hepatitis C, ChronicDeregulated Nutrient SensingAmino acid substitutions in the HCV genotype 1b core region are associated with hepatic steatosis in patients with chronic hepatitis C, independent of glucose intolerance.21054524
Inflammation, Cardiac complication, Chronic Kidney DiseasesDeregulated Nutrient SensingLow-grade systemic inflammation, oxidative stress and peripheral insulin resistance are intimately associated and contribute to the increased risk of cardiovascular complications in advanced chronic kidney disease (CKD).21054584
Vascular lesions, DyslipidemiasDeregulated Nutrient Sensing[Relationship between dyslipidemia and early vascular lesions in obese children and adolescents].21055261
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHigher prevalence of hypertension was found in patients with dyslipidemia.21055261
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient Sensing(2) Vascular lesions are closely related with dyslipidemia, and waist circumference and hypertriglyceridemia are the risk factors.21055261
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia as evidenced by the lipid triad: prevalence and associated risk in statin-treated patients in ambulatory care.21058895
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingLow-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes.21059863
ObesityDeregulated Nutrient SensingAnimal studies have revealed the association between stearoyl-CoA desaturase 1 (SCD1) and obesity and insulin resistance.21060977
OverweightDeregulated Nutrient SensingThe insulin resistance was calculated in 40 morbidly obese patients and 11 overweight controls.21060977
ObesityDeregulated Nutrient SensingIn conclusion, these data suggest that the regulation of SCD1 is altered in individuals with morbid obesity and that the SCD1 protein has a different regulation in the two adipose tissues, as well as being closely linked to the degree of insulin resistance.21060977
Prostate carcinomaDeregulated Nutrient SensingMelatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model.21062352
Prostate carcinoma, Structure of posterior cerebral arteryDeregulated Nutrient SensingWe recently demonstrated that Sirt1, a NAD(+) -dependent histone deacetylase, was overexpressed in prostate cancer (PCa) and its inhibition resulted in a significant antiproliferative response in human PCa cells.21062352
Primary malignant neoplasmDeregulated Nutrient SensingStudies have suggested a link between Sirt1 and circadian rhythms, the disruption of which has been linked to cancer.21062352
Structure of posterior cerebral arteryDeregulated Nutrient SensingHere, we challenged our hypothesis that melatonin will impart antiproliferative response against PCa via inhibiting Sirt1.21062352
ProstateDeregulated Nutrient SensingThis anti-PCa response was accompanied with a significant decrease in Sirt1 in TRAMP prostate.21062352
ETV3 wt AlleleDeregulated Nutrient SensingAs one goal of the MetS definition is to facilitate the clinical identification of insulin-resistant individuals, other biomarkers of insulin resistance have been explored.21062616
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance profile among siblings of type 2 diabetes mellitus (preliminary study).21063041
Hypertriglyceridemia, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAmong subjects with insulin resistance, all have central obesity, half of them have hypertension, decreased HDL cholesterol level and hyper-triglyceridemia.21063041
Hypertension, CTCAE, Peripheral Arterial Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLower-extremity peripheral artery disease (LE-PAD), is strongly related to traditional risk factors (smoking, hypertension, dyslipidemia, diabetes).21067754
Adrenal incidentalomaDeregulated Nutrient SensingThe size of adrenal incidentalomas correlates with insulin resistance.21070314
Adrenal incidentalomaDeregulated Nutrient SensingAdrenal incidentalomas (AI) have often been associated with a high prevalence of insulin resistance (IR) and cardiovascular risk factors, although direct measurement of insulin sensitivity (IS) has never been carried out.21070314
Non-Functioning Endocrine NeoplasmDeregulated Nutrient SensingOur study showed a high prevalence of insulin resistance in patients with nonfunctioning AI and suggests its possible involvement in AI growth.21070314
ObesityDeregulated Nutrient SensingPlasminogen activator inhibitor 1 (PAI-1) is thought to play a role in the pathogenesis of obesity and insulin resistance.21070757
EpendymomaDeregulated Nutrient SensingmTORC1 activation in childhood ependymoma and response to sirolimus.21076853
NeoplasmsDeregulated Nutrient SensingImmunohistochemistry for phosphorylated S6, which has been reported to be associated with tumor sensitivity to mTORC1 inhibitors, was positive in this patient's tumor.21076853
AnemiaDeregulated Nutrient SensingComplete correction of anemia by erythropoiesis-stimulating agents is associated with insulin resistance in hemodialysis patients.21076998
Kidney Failure, Chronic, AnemiaDeregulated Nutrient SensingInsulin resistance and anemia secondary to erythropoietin deficiency characterize patients with end-stage kidney disease.21076998
DiseaseDeregulated Nutrient SensingInsulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals.21081660
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings show that GES technology can be used for both the discovery of insulin-sensitizing compounds and the characterization of patients into subtypes of insulin resistance according to GES scores, opening the possibility of developing a personalized medicine approach to type 2 diabetes.21081660
Colorectal Carcinoma, ObesityDeregulated Nutrient SensingAssociation of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.21081932
Inflammation, Primary malignant neoplasm, Colorectal Carcinoma, ObesityDeregulated Nutrient SensingThis study investigated the relationship of obesity, insulin resistance, inflammation and angiogenesis with cancer progression and survival in a colorectal cancer cohort.21081932
Atherosclerosis of renal artery, Apolipoprotein E, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient Sensing[Association of the serum level of apolipoprotein E with coronary artery disease and carotid artery atherosclerosis in Kyrgyz men with dyslipidemia].21086615
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and the defective function of pancreatic b-cells can occur several years before the development of type 2 diabetes.21087821
PoisoningDeregulated Nutrient SensingThe mechanism of action of ILE is not known, including its role in insulin resistance and myocardial metabolism in calcium-channel blocker poisoning.21088599
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is an important but modifiable risk factor of cardiovascular disease (CVD) in type 2 diabetes.21092182
diabeticDeregulated Nutrient SensingEffects of one year treatment of sibutramine on insulin resistance parameters in type 2 diabetic patients.21092710
Gastrointestinal inflammation, ObesityDeregulated Nutrient SensingBased on animal studies, RELMb is induced by high fat diets, obesity, and intestinal microflora and may play a role in insulin resistance and intestinal inflammation.21094111
DyslipidemiasDeregulated Nutrient SensingCombinations of statins and fibrates may be increasingly prescribed to achieve lipid goals in high-risk patients and those with other cardiovascular risk factors, such as mixed dyslipidemia.21094360
Congestive heart failureDeregulated Nutrient SensingRecently, hemoglobin A1(c) (HbA1(c)) levels have been reported to be an independent risk factor for mortality in CHF, suggesting the important role of insulin resistance in CHF.21095280
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and insulin resistance are characterized by a chronic and low grade state of inflammation and the pro-inflammatory response of monocytes is affected in type 2 diabetes mellitus (T2D).21104588
Diabetes Mellitus, Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and insulin resistance have been linked to rising incidence and earlier onset of Type 1 diabetes.21105490
Diabetes Mellitus, Insulin-Dependent, HereditaryDeregulated Nutrient SensingInherited differences in insulin action might also influence the evolution of Type 1 diabetes.Our aim was to determine whether parental BMI and insulin resistance influences age of onset of Type 1 diabetes in their offspring.21105490
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingMaternal HOMA-IR accounted for 20% of variation in age at diagnosis (P < 0.001) with increasing maternal insulin resistance associated with later age at diagnosis of Type 1 diabetes.21105490
Diabetes Mellitus, Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingChildrenwith Type 1 diabetes and their parents have an increased BMI at diagnosis.Maternal insulin resistance is associated with later onset of Type 1 diabetes in children.21105490
PrehypertensionDeregulated Nutrient SensingPrehypertension and insulin resistance among Mongolian people, Inner Mongolia, China.21105761
PrehypertensionDeregulated Nutrient SensingThere is little knowledge on association of prehypertension with insulin resistance among Mongolian people.21105761
PrehypertensionDeregulated Nutrient SensingThe purpose of the present study is to explore whether there are phenomena of insulin resistance in the phase of prehypertension in the Mongolian population.21105761
Hypertension, CTCAE, PrehypertensionDeregulated Nutrient SensingPrehypertension was significantly associated with insulin resistance in the Mongolian population, and this study suggest that insulin resistance may play an important role in development of hypertension.21105761
Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary heart disease, Depression, CTCAE, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDepression was related to diabetes (OR=1.99, 95% CI=1.26-3.15), dyslipidemia (OR=1.35, 95% CI=1.02-1.79), coronary heart disease (CHD; OR=1.88, 95% CI=1.04-3.39), and the history of stroke (OR=2.43, 95% CI=1.02-5.76).21106250
Mitochondria, MuscleDeregulated Nutrient SensingHere, we show that MCAT mice are protected from age-induced decrease in muscle mitochondrial function (~30%), energy metabolism (~7%), and lipid-induced muscle insulin resistance.21109199
Weight Gain, DyslipidemiasDeregulated Nutrient SensingThe side-effects associated with androgen deprivation therapy (ADT) include weight gain, dyslipidemia, and insulin resistance.21109456
Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingCarotid and femoral plaque burden is inversely associated with the a-linolenic acid proportion of serum phospholipids in Spanish subjects with primary dyslipidemia.21111420
Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingCross-sectional study of 211 patients with primary dyslipidemia, with determination of fatty acid composition of serum phosphatidylcholine by gas chromatography and plaque outcomes (frequency, number, maximum height and sum of plaque heights) in carotid and femoral arteries by sonography.21111420
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingIn the univariate logistic regression analyses, poor outcomes, defined as mRS scores of >2, at 30 days were significantly related to high serum pentosidine (P = .001), type of stroke (P = .045), old age (P = .02), male sex (P = .042), and the absence of dyslipidemia (P = .02).21111635
Chronic Kidney DiseasesDeregulated Nutrient Sensing[Insulin resistance in chronic kidney disease: its clinical characteristics and prognosis significance].21113216
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) increases significantly the risk for cardiovascular disease (CV) in the general population.21113216
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is a strong predictor of myocardial infarction in subjects with chronic kidney disease.21114460
ObesityDeregulated Nutrient SensingWe hypothesized that the strong association between insulin resistance and circulating amounts of C3 may be related to hepatic fat accumulation -independent of central obesity itself and of a general low-grade inflammatory response.21114489
Inflammation, ObesityDeregulated Nutrient SensingPlasma ALT can explain 14*2% of the strong association between insulin resistance and circulating concentrations of complement C3, independent of central obesity and general inflammation.21114489
Breast CarcinomaDeregulated Nutrient SensingAssociations of insulin resistance and adiponectin with mortality in women with breast cancer.21115858
Breast CarcinomaDeregulated Nutrient SensingHere, we evaluate whether low levels of adiponectin and a greater level of insulin resistance are associated with breast cancer mortality and all-cause mortality.21115858
Data types - AddressDeregulated Nutrient SensingWe investigated whether fasting glucose and insulin levels and insulin resistance are associated with the risk of AD and whether this risk is constant over time.21115952
Breast Carcinoma, Primary malignant neoplasm, Epithelial cell count (procedure)Deregulated Nutrient SensingVariation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC).21116708
Dyslipidemias, Coronary Arteriosclerosis, Metabolic Syndrome XDeregulated Nutrient SensingPatients with metabolic syndrome are at increased risk of atherosclerotic coronary heart disease, often have mixed dyslipidemia, and may thus require more aggressive treatment of multiple lipid parameters.21117970
Hyperthyroidism, Glucose Intolerance (disease), HypothyroidismDeregulated Nutrient SensingHypothyroidism can decrease insulin requirement in such patients and hyperthyroidism may cause glucose intolerance.21121384
Hyperglycemia, Sleep Apnea, ObstructiveDeregulated Nutrient SensingObstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance.21121505
Dyslipidemias, Metabolic Syndrome X, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOur data suggest that obesity, hypertension, dyslipidemia, and metabolic syndrome in T2DM were associated with increased plasma leptin levels.21121702
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, which has been closely linked to pathophysiology of cardiovascular diseases, is a key independent modifiable risk factor for cardiovascular diseases.21122627
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingEstimation of the prevalence of dyslipidemia ensures proper planning of health actions for both primary and secondary prevention of cardiovascular diseases.21122627
Hyperlipidemia, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingWe compared the plasma of patients with combined hyperlipidemia and the dyslipidemia of hypothyroidism with those with type III HL.21122636
Inflammatory Bowel Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and lipoprotein profiles in patients with inflammatory bowel disease.21122694
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia is a major risk factor for developing coronary artery disease.21122694
Inflammatory Bowel Diseases, DyslipidemiasDeregulated Nutrient SensingThe purpose of this study is to identify and describe dyslipidemia and lipoprotein profiles in an IBD patient population.21122694
Inflammatory Bowel Diseases, DyslipidemiasDeregulated Nutrient SensingGiven low levels of HDL-C and increased levels of LDL-C, a more aggressive approach in profiling and treating dyslipidemia seems warranted in patients with IBD.21122694
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSerum visfatin is associated with type 2 diabetes mellitus independent of insulin resistance and obesity.21122936
Obesity, Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to evaluate the association of serum visfatin, adiponectin and leptin with 2 diabetes mellitus (T2DM) in the context of the role of obesity or insulin resistance, which is not well understood.21122936
ObesityDeregulated Nutrient SensingElevation of visfatin in T2DM is independent of obesity and insulin resistance and is mainly determined by fasting glucose and triglycerides.21122936
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingProteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence.21124077
Non-Small Cell Lung Carcinoma, NeoplasmsDeregulated Nutrient SensingIn tumors from patients with resected NSCLC, expression of proteins in the energy-sensing AMPK pathway (pLKB1, AMPK, p-Acetyl-CoA, pTSC2), adhesion, EGFR, and Rb signaling pathways was inversely associated with NSCLC recurrence.21124077
Inflammation, ObesityDeregulated Nutrient SensingToll-like-receptor 4 (TLR) is discussed to provide a molecular link between obesity, inflammation and insulin resistance.21125016
ObesityDeregulated Nutrient SensingThis finding supports the role of TLR4 as a molecular link between obesity and insulin resistance.21125016
HIV InfectionsDeregulated Nutrient SensingAdiponectin and leptin in Afro-Caribbean men and women with HIV infection: association with insulin resistance and type 2 diabetes.21126901
HIV, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and type 2 diabetes (T2D) are commonly seen in human immunodeficiency virus (HIV) infection and are related to antiretroviral therapy.21126901
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevalences of T2D and insulin resistance were higher in women than in men [16.2% vs 8.3% (P = 0.06) and 24% vs 9.9% (P < 10-3), respectively].21126901
HIV InfectionsDeregulated Nutrient SensingInsulin resistance is frequent in Afro-Caribbean women with HIV infection.21126901
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSystematic screening for insulin resistance should be carried out in this population, which has a high prevalence of T2D.21126901
HyperprolactinemiaDeregulated Nutrient SensingHyperprolactinemia has been associated with impaired metabolism, including insulin resistance.21128120
Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, FAM126A gene, Hypertension, CTCAEDeregulated Nutrient SensingPatients with NAFLD/NASH-associated HCC exhibited a higher prevalence of metabolic features (Type 2 diabetes mellitus, hypertension, dyslipidemia, coronary artery disease) compared to non-NAFLD/NASH-HCC.21128245
F11 gene, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingFVIII, FIX, FXI and FXII activities are increased in human NAFLD and correlate with the features of insulin resistance.21134109
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) has been associated with cardiovascular diseases (CVD).21134267
Glucose Intolerance (disease), Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingChronic exposure to glucocorticoids (GCs) has many side effects including glucose intolerance and diabetes and may accelerate the occurrence of cardiovascular disease and increase mortality.21138532
HyperglycemiaDeregulated Nutrient SensingA higher level of insulin resistance as measured by HOMA-IR after the improvement of hyperglycemia (3.6 vs. 6.8) suggested that the long use of olanzapine reduced insulin secretion.21139307
Hyperlipidemia, Fatty Liver DiseaseDeregulated Nutrient SensingThe use of policosanols is shown effective in the treatment of associated hyperlipidemia and insulin resistance in patients with fatty liver disease.21139538
AtherosclerosisDeregulated Nutrient SensingLosartan, an angiotensin II receptor blocker (ARB), has been reported to increase serum level of high-molecular weight (HMW) adiponectin, which has beneficial effects on insulin resistance and atherosclerosis.21142812
ETV3 wt AlleleDeregulated Nutrient SensingThe interaction between increased hsCRP and GGT was a significant and independent determinant for MetS and insulin resistance in both genders.21143879
ETV3 wt AlleleDeregulated Nutrient SensingThese results suggested that higher CRP and GGT levels were synergistically associated with MetS and insulin resistance, independently of other confounding factor in the general population.21143879
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingTherapeutic inertia in the outpatient management of dyslipidemia in patients with ischemic heart disease.21144403
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingOur aims were to investigate this phenomenon, known as therapeutic inertia, in patients with dyslipidemia and ischemic heart disease, and to determine its possible causes.21144403
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingTherapeutic inertia occurred more frequently when there was a long time between the diagnosis and treatment of dyslipidemia and that of ischemic heart disease.21144403
Chronic myocardial ischemia, DyslipidemiasDeregulated Nutrient SensingTherapeutic inertia was common in patients with chronic ischemic heart disease and dyslipidemia, irrespective of overall cardiovascular risk.21144403
ConstitutionalDeregulated Nutrient SensingSasang constitutional types can act as a risk factor for insulin resistance.21146241
Skin NeoplasmsDeregulated Nutrient SensingFinally, we show that SIRT1 levels are significantly reduced in human skin tumors from Caucasian patients, a population at highest risk.21149730
NeoplasmsDeregulated Nutrient SensingThese findings suggest that SIRT1 acts as a tumor suppressor through its role in DNA repair.21149730
Prostate Cancer Outcomes Study, Dyslipidemias, HyperandrogenismDeregulated Nutrient SensingMale individuals who are first-degree relatives of patients with PCOS have a higher degree of dyslipidemia and insulin resistance, lower levels of SHBG, and more evident clinical signs of hyperandrogenism.21152842
Prostate Cancer Outcomes Study, HereditaryDeregulated Nutrient SensingThese findings suggest that insulin resistance may be of hereditary origin in individuals with a family history of PCOS regardless of anthropometric parameters.21152842
Intracranial Arterial Diseases, Secondary physiologic amenorrhea, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRadiological studies showed multiple intracranial arterial stenoses, and laboratory examination revealed diabetes mellitus, dyslipidemia, and endocrinological abnormalities consistent with secondary amenorrhea.21153600
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been variably associated with insulin resistance and type 2 diabetes (T2D) in several populations.21153685
Colorectal Neoplasms, ObesityDeregulated Nutrient SensingInsulin resistance is thought to mediate the association between obesity and colorectal neoplasia, but no prior studies have assessed stimulated insulin sensitivity as a risk factor for colorectal neoplasia.21154114
Metabolic DiseasesDeregulated Nutrient SensingInsulin resistance and adiponectin are markers of cardio-metabolic disease and associated with adverse cardiovascular outcomes.21156037
TG gene, Dyslipidemias, Data types - AddressDeregulated Nutrient SensingT2DM is associated with atherogenic dyslipidemia (AD), defined as decreased HDL-C plus raised triglycerides (TG).21156040
ObesityDeregulated Nutrient SensingThe over-expression of CB1 in adult obesity is associated with insulin resistance (IR),but it is not elucidated in childhood obesity.21158212
ObesityDeregulated Nutrient SensingBy using multivariate analysis, we found that factors significantly associated with obesity among women were diastolic blood pressure, insulin resistance, and employment status.21159215
Obesity, Diabetes MellitusDeregulated Nutrient SensingBoth apoB and apoA1 were significantly associated with obesity when age, sex, diastolic blood pressure, homocysteine, diabetes, and insulin resistance were controlled for.21159217
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity.21167068
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingTherefore, the association among CRP, insulin resistance and obesity was analyzed in Chinese patients with type 2 diabetes.21167068
Inflammation, Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings showed that insulin resistance was associated with CRP levels independent of abdominal obesity in Chinese patients with type 2 diabetes, suggesting that abdominal obesity could only partly explain the link between subclinical inflammation and insulin resistance.21167068
Malignant neoplasm of prostate, Neurogenic Urinary Bladder, Dyslipidemias, prostatitis, Heart failure, Acute retention of urine, Urethral Stenosis, Diabetes Mellitus, Non-Insulin-Dependent, Liver CirrhosisDeregulated Nutrient SensingPatients with heart failure, liver cirrhosis, prostatic cancer, neurogenic bladder, acute prostatitis, acute urinary retention, urethral stenosis, history of transurethral resection or any drug treatment for BPH, or currently under drug treatment for type 2 diabetes mellitus or dyslipidemia were excluded.21168193
diabeticDeregulated Nutrient SensingThese effects are amplified in diabetic individuals with characteristics that are associated with insulin resistance or with oxidative stress.21169129
Glucose Intolerance (disease), Acromegaly, Diabetes MellitusDeregulated Nutrient SensingFrequency of acromegaly in adults with diabetes or glucose intolerance and estimated prevalence in the general population.21170595
IschemiaDeregulated Nutrient SensingAutophagy is activated by ischemia and nutrient starvation in the heart through Sirt1-FoxO- and adenosine monophosphate (AMP)-activated protein kinase (AMPK)-dependent mechanisms, respectively.21170742
DyslipidemiasDeregulated Nutrient SensingCirculating trans-palmitoleate is associated with lower insulin resistance, presence of atherogenic dyslipidemia, and incident diabetes.21173413
Dyslipidemias, Polycystic Ovary Syndrome, Diabetes MellitusDeregulated Nutrient SensingPolycystic ovary syndrome is associated with subsequent incident diabetes and dyslipidemia, independent of BMI.21173640
Inflammation, diabeticDeregulated Nutrient SensingAngiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation.21175613
Kidney CalculiDeregulated Nutrient SensingImpact of insulin resistance, insulin and adiponectin on kidney stones in the Japanese population.21175865
Increased insulin level, ETV3 wt Allele, Kidney CalculiDeregulated Nutrient SensingThe findings suggest that MetS components could increase the risk of kidney stones through subclinical hyperinsulinemia and insulin resistance.21175865
HD Term TypeDeregulated Nutrient SensingHowever, data on insulin resistance and erythropoietin responsiveness in HD patients are lacking.21176750
HD Term TypeDeregulated Nutrient SensingWe conducted a prospective, observational cohort study to clarify the relationship between insulin resistance and erythropoietin responsiveness in HD patients.21176750
HD Term TypeDeregulated Nutrient SensingInsulin resistance as established by HOMA-IR and adiponectin was associated with EPO responsiveness in HD patients.21176750
HD Term TypeDeregulated Nutrient SensingInsulin resistance is associated with EPO responsiveness in HD patients.21176750
HD Term TypeDeregulated Nutrient SensingFor improvement in EPO response, insulin resistance may be a new target for treating HD patients.21176750
Rhinosinusitis, Osteoporosis, Dyslipidemias, Diabetes Mellitus, Depression, CTCAEDeregulated Nutrient SensingAsthma was also weakly associated with depression, diabetes mellitus, dyslipidaemia, osteoporosis and rhinosinusitis.21177843
Diabetes MellitusDeregulated Nutrient SensingHowever, it still remains unclear if these elevated IL-6 levels are co-incidental or if this cytokine is causally related to the development of insulin resistance and type 2 diabetes in humans.21179199
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInhibition of IL-6 signalling improves insulin sensitivity in humans with immunological disease suggesting that elevated IL-6 levels in type 2 diabetic subjects might be causally involved in the pathogenesis of insulin resistance.21179199
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingPatients with CAD, hypertension, dyslipidemia, obesity and high C-reactive protein levels were at high risk of AGM.21185615
Hyperlipidemia, Hypertension, CTCAE, Hyperuricemia, ObesityDeregulated Nutrient SensingHowever, debates still exist on the independent role of hyperuricemia, due to its association with several cardiovascular risk factors, such as hypertension, hyperlipidemia, obesity and insulin resistance.21186110
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient Sensinginsulin resistance is known to be the most important pathogenic factor in the development of nonalcoholic fatty liver disease.21187187
Renal Insufficiency, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingFurther adjustments for obesity, hypertension, insulin resistance, dyslipidemia, and renal dysfunction eliminated these associations.21187261
Inflammation, Obesity, AbdominalDeregulated Nutrient SensingED is decreased in morbidly obese subjects associated with insulin resistance and inflammation parameters although abdominal obesity seems to be of paramount importance in altering this rheological parameter.21187580
Tuberculosis, Dyslipidemias, Post-Traumatic Stress Disorder, Anxiety, CTCAE 3.0, Depression, CTCAE, Sleeplessness, Hypertension, CTCAEDeregulated Nutrient SensingMedical conditions included: major depression (45%), PTSD (48%), anxiety (31%), insomnia (50%), hypertension (29%), dyslipidemia (6%), HIV (6%) and tuberculosis class 2-4 (32%).21188531
Dyslipidemias, Toxic effectDeregulated Nutrient Sensingour findings suggest that atorvastatin and rosuvastatin are preferable to pravastatin for treatment of HIV-infected patients with dyslipidemia, due to greater declines in total cholesterol, LDL-C, and non-HDL-C, with similar lower toxicity rates.21189273
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIndividuals with SD T2DM are at high risk of CVD as a result of untreated hyperglycaemia, hypertension and dyslipidaemia.21194777
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity (46.3% vs 32.0%; P < 0.001), hypertension (86.7% vs 77.8%; P < 0.001), and dyslipidemia (61.2% vs 55.0%; P < 0.05) were significantly more common in women than in men, respectively.21195360
Inflammation, Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingOur results suggest that AT inflammation in obese COPD patients relates to insulin resistance.21197447
Heart Diseases, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe rates of hypertension (17%) and dyslipidemia (15%) were lower than rates reported in other national samples; however, the rate for family history of premature heart disease (20%) was similar to those reported in national samples.21206350
Hyperparathyroidism, PrimaryDeregulated Nutrient SensingPrimary hyperparathyroidism (PHPT) is characterized by high OC levels and insulin resistance.21207016
SchizophreniaDeregulated Nutrient SensingTriglyceride/high-density lipoprotein cholesterol ratio: a surrogate to predict insulin resistance and low-density lipoprotein cholesterol particle size in nondiabetic patients with schizophrenia.21208572
Diabetes MellitusDeregulated Nutrient SensingHowever, stepwise multiple regression analysis suggested that the triglyceride/HDL ratio is a stronger predictor of insulin resistance and of LDL particle size than other conventional lipoprotein measures after other potential confounding variables, including age, gender, race, family history of diabetes, body mass index, and antipsychotic agent, were taken into consideration (P < .001).21208572
SchizophreniaDeregulated Nutrient SensingThe triglyceride/HDL ratio, a simple, readily available and inexpensive measure, can be a useful surrogate to identify those with insulin resistance as well as those with more atherogenic small LDL particles in nondiabetic patients with schizophrenia.21208572
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance.21208674
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories.21208674
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingAt baseline nearly half the patients (45%) had a diagnosis of hypertension, a third (34%) had dyslipidemia, and 15% had a diagnosis of obesity.21209299
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes and dyslipidaemia were independent predictors of decreased primary patency rate (P = 0.013 and P = 0.008, respectively).21211456
Diabetes MellitusDeregulated Nutrient SensingPatients with higher BMI and no insulin resistance or diabetes mellitus present better long-term outcomes following anterior AMI.21213110
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients with MAC were generally older and had a higher prevalence of systemic hypertension, diabetes mellitus, and dyslipidemia.21214099
Dyslipidemias, ObesityDeregulated Nutrient SensingThe prevalence of underweight/overweight, central obesity, dyslipidemia and impaired fasting glucose (IFG) were calculated.21214302
Dyslipidemias, ObesityDeregulated Nutrient SensingCentral obesity increased the chances of IFG (OR:8.000, CI:1.6-39.1) and doubled the prevalence of dyslipidemia (OR:2.190, CI:0.5-9.1).21214302
Dyslipidemias, Mental disorders, Diabetes MellitusDeregulated Nutrient SensingIn comparison with other older individuals, those infected with HIV tend to have higher rates of liver-related conditions, diabetes, and dyslipidemia, as well as substance use and psychiatric disorders.21216627
Diabetes MellitusDeregulated Nutrient SensingThe relation of diabetes, impaired fasting blood glucose, and insulin resistance to left ventricular structure and function in African Americans: the Jackson Heart Study.21216853
Diabetes MellitusDeregulated Nutrient SensingWe assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans.21216853
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients treated with exenatide tended to be obese, middle-aged women on various combinations of OADs and/or insulin who often had hypertension and/or dyslipidemia.21219119
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and dyslipidaemia both increase cardiovascular risk in Type 1 diabetes.21219421
Diabetes MellitusDeregulated Nutrient SensingHowever, little data exist on the associations of insulin resistance to lipids in Type 1 diabetes.21219421
Hyperglycemia, Endothelial dysfunctionDeregulated Nutrient SensingL-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM.21220248
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing[Association between both resistin, visfatin and insulin resistance as well as b cell function in the first-degree relatives of type 2 diabetes mellitus].21223671
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo study the association between the levels of serum resistin, visfatin and insulin resistance as well as b-cell dysfunction in the first-degree relatives (FDR) of type 2 diabetes mellitus (T2DM), and to investigate the role of these adipocytokines in pathogenesis of T2DM.21223671
Inflammation, OverweightDeregulated Nutrient SensingHealthy men and women with Co-PreHTN+PreDM were, on average, overweight with a large waist circumference, displayed an exacerbated systemic inflammation and higher insulin resistance.21228791
AlbuminuriaDeregulated Nutrient SensingInsulin resistance is associated with reduced serum adiponectin and increased albuminuria levels.21229348
SLC25A20 gene, Electrocardiogram: myocardial infarction (finding), Angina Pectoris, ObesityDeregulated Nutrient SensingAmong women without CAC, angina was related to variables reflecting obesity and insulin resistance and was independently associated with African-American ethnicity, premature family history of myocardial infarction, and waist circumference (all p < 0.05).21232706
No metabolic abnormalities, OverweightDeregulated Nutrient SensingBeing overweight with metabolic abnormalities, particularly insulin resistance, low high-density lipoprotein cholesterol level, and visceral adiposity, may adversely influence adolescent bone mass.21232765
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma NOx levels did not predict glucose intolerance or insulin resistance before the development of T2D and the increase in plasma NOx levels in T2D was not caused by adiposity.21233590
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma NOx concentrations in glucose intolerance and type 2 diabetes.21233590
Refractory anemias, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHowever, low total physical activity was associated with dyslipidemia, insulin resistance, low levels of atheroprotective anti-PC and consumption of saturated fatty acids, which is of interest in the context of increased frequency of cardiovascular disease in RA.21235741
Inflammation, Diabetes MellitusDeregulated Nutrient SensingIn premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation.21239514
Coronary heart disease, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAdiponectin is present in low concentration in patients with obesity, insulin resistance (IR), Type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).21240167
Choline Dehydrogenase, Mitochondrial, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIt may be concluded that low serum adiponectin may have some important role in development of CHD and probably low adiponectin and dyslipidemia are linked in the development of atherosclerosis.21240167
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHere, we show that SIRT1 protein expression is decreased in muscle biopsies and primary myotubes derived from type 2 diabetic patients, suggesting a contribution of diminished SIRT1 in the determination of muscle insulin resistance.21241768
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is hallmarked by insulin resistance and insufficient b-cell function.21242957
Hyperthyroidism, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe rate of occurrence of variable glucose intolerance was 28% with frank diabetes mellitus diagnosed in 9% of the cases of hyperthyroidism.21243857
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of pitavastatin and atorvastatin on the lipid profile and lipoprotein subclasses were compared in patients with Type 2 diabetes with dyslipidaemia.21244474
Inflammation, Hyperparathyroidism, Dyslipidemias, PathologyDeregulated Nutrient SensingOn-line high-efficiency HDF resulted in enhanced removal and lower basal levels of small, medium-sized and protein-bound solutes, which are markers or causative agents of uraemic pathologies, mainly inflammation, secondary hyperparathyroidism and dyslipidaemia.21245130
Diabetes Mellitus, Non-Insulin-Dependent, physiopathologicalDeregulated Nutrient SensingAssociation of restrictive ventilatory dysfunction with insulin resistance and type 2 diabetes in koreans.21246464
Demographics Domain, physiopathological, Diabetes MellitusDeregulated Nutrient SensingTo investigate associations of obstructive and restrictive patterns of ventilatory dysfunction with insulin resistance and type 2 diabetes mellitus (DM) in Koreans.21246464
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia were present in 88.7% and 65.5% of patients, respectively.21247449
DyslipidemiasDeregulated Nutrient SensingIn conclusion, these data suggest that a combination of fenofibric acid and a statin could be considered safe and efficacious for treating women with mixed dyslipidemia.21247520
Kidney DiseasesDeregulated Nutrient SensingCorrelates of insulin resistance in older individuals with and without kidney disease.21248294
Chronic Kidney DiseasesDeregulated Nutrient SensingChronic kidney disease (CKD) is associated with insulin resistance (IR).21248294
Homocysteinemia, Dyslipidemias, Hypertension, CTCAE, Cerebrovascular accidentDeregulated Nutrient SensingCardiovascular risk factors (CVRF) were: dyslipidemia (62.8%), moderate homocysteinemia (55%), BMI>25 (39%) and hypertension (35%) which is associated with a stroke (P<0.0006).21248669
Proteinuria, Dyslipidemias, Chronic Kidney Diseases, Lupus ErythematosusDeregulated Nutrient SensingPersistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus.21248713
Proteinuria, Renal function, Dyslipidemias, Lupus NephritisDeregulated Nutrient SensingProgressive loss of kidney function developed exclusively in patients with lupus nephritis who had persistent proteinuria and dyslipidemia, although only six required dialysis or transplantation.21248713
Proteinuria, Idiopathic glomerular disease, Dyslipidemias, Chronic Kidney Diseases, Lupus ErythematosusDeregulated Nutrient SensingHence, as in idiopathic glomerular disease, persistent proteinuria and dyslipidemia (modifiable risks) are the major factors for CKD progression in lupus patients with renal involvement.21248713
ObesityDeregulated Nutrient SensingIn obesity, adipose tissue 11bHSD1 is upregulated, leading to the generation of higher tissue levels of cortisol, which may increase insulin resistance.21249616
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe tested the hypothesis that elevated tHcy levels are correlated with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes.21250986
Hippocampal atrophy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results indicate that the elevated levels of tHcy in Japanese nondementia patients with type 2 diabetes are characterised by hippocampal atrophy and insulin resistance and that the Z-score and HOMA index may be the primary factors that influence tHcy levels.21250986
Metabolic Syndrome X, Cardiovascular Diseases, Increased circulating renin level, Hypoadiponectinemia, Diabetes Mellitus, Non-Insulin-Dependent, MS geneDeregulated Nutrient SensingMeta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 diabetes (T2DM), metabolic syndrome (MS) and cardiovascular disease.21251282
Inflammation, Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingTertiary outcomes will be biochemical markers reflecting common pathophysiological processes of insulin resistance, inflammation and oxidative damage that are assumed to be intertwined in both diabetes and depression.21251307
Arthralgia, Hypertension, CTCAE, Dyslipidemias, Osage languageDeregulated Nutrient SensingResolution occurred in 74% of patients with T2DM, 53% with hypertension, 45% with dyslipidemia, 76% with OSA, 38% with joint pain and 20% with depression/anxiety.21251414
Carcinoma of lungDeregulated Nutrient SensingInsulin resistance: an independent risk factor for lung cancer?21251684
Metabolic DiseasesDeregulated Nutrient SensingInsulin resistance is closely associated with numerous metabolic disorders.21251684
Carcinogenesis, Carcinoma of lungDeregulated Nutrient SensingAlthough studies have supported the importance of insulin resistance in carcinogenesis, the existing data have not established its relevance in the context of lung cancer.21251684
Carcinoma of lungDeregulated Nutrient SensingInsulin resistance may represent a meaningful risk factor for lung cancer.21251684
Cardiovascular DiseasesDeregulated Nutrient SensingAbdominal fat-related activation of the innate immune system and insulin resistance (IR) are implicated in the pathogenesis of cardiovascular diseases.21253003
Glucose Intolerance (disease), Cystic FibrosisDeregulated Nutrient SensingGlucose intolerance in patients with cystic fibrosis: sex-based differences in clinical score, pulmonary function, radiograph score, and 6-minute walk test.21255491
Inflammation, Chronic pain, Depression, CTCAEDeregulated Nutrient SensingPatients with CIAP usually suffer from chronic pain and associated depression, both of which have been proposed to cause insulin resistance (IR) by such mechanisms as a sustained increase in the corticosteroids and catecholamines, and chronic low grade inflammation.21255940
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSUBJECT AND AIMS: Endothelial derived nitric oxide (eNOS) is involved in several functions playing important role in development of type 2 diabetes and insulin resistance.21256614
AtherosclerosisDeregulated Nutrient SensingHowever, the relative value of MS, apoB lipoproteins, and estimates of insulin resistance is unknown in predicting atherosclerosis in DM.21257006
Calcification of coronary artery, AtherosclerosisDeregulated Nutrient SensingIn conclusion, insulin resistance estimates add value to MS and apoB in predicting coronary artery calcification scores in DM and warrant further evaluation in clinic for identification of patients with DM at higher risk for atherosclerotic cardiovascular disease.21257006
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingFemale sex, old age, diabetes mellitus, hypertension, dyslipidemia, and obesity were more prevalent in NSTEACS patients.21259279
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingCorrelates of acute insulin resistance in the early phase of non-diabetic ST-elevation myocardial infarction.21262869
glucose metabolism, Diabetes MellitusDeregulated Nutrient SensingInsulin was directly and significantly related to glycaemia (p = 0.0006), body mass index (BMI) (p = 0.00028) and lactate (p = 0.0096) In the early phase of STEMI without previously known diabetes the acute glucose dysmetabolism is quite complex, comprising increased glucose values and the development of acute insulin resistance.21262869
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes MellitusDeregulated Nutrient SensingEarly detection of high-risk individuals for MS using accurate measures of insulin resistance (IR) could improve detection and prevention of CVD and diabetes.21262912
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe purposes of this study were to (1) describe anthropometric measures among Korean immigrants with type 2 diabetes mellitus (T2DM) and (2) examine the relationships between measures of obesity with several forms of dyslipidemia in this group.21263345
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Obesity, Choline Dehydrogenase, Mitochondrial, Cessation of lifeDeregulated Nutrient SensingObesity and dyslipidemia are commonly associated with T2DM, and they are risk factors for coronary heart disease (CHD), the leading cause of death for people with diabetes.21263345
DyslipidemiasDeregulated Nutrient SensingCentral obesity measures, not BMI, were significantly associated with dyslipidemia in Korean immigrants with T2DM independent of potential confounds such as hemoglobin A1C, cigarette smoking, age, and cholesterol medication.21263345
Obesity, Abdominal, Overweight, Dyslipidemias, ObesityDeregulated Nutrient SensingHigher values were observed for smoking (65.0%), clinical or laboratory dyslipidemia (59.1% and 52.0%), careless diet (78.4%), sedentary lifestyle (64.2%), overweight or obesity (64.2%) and abdominal obesity (50.9%).21265491
Schizophrenia, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingUntreated hypertension, untreated dyslipidemia and untreated diabetes are strongly associated with schizophrenia (3.79 [1.63-8.81]), (3.79 [2.06-7.35]), (6.38 [1.725-23.59]), respectively.21265491
palladium, Hyperlipidemia, Exocrine pancreatic insufficiencyDeregulated Nutrient SensingDe novo NAFLD/NASH after PD is characterized by non-obesity and lack of hyperlipidemia and insulin resistance and is associated with pancreatic exocrine insufficiency.21267748
Hypertension, CTCAE, Kidney Failure, DyslipidemiasDeregulated Nutrient SensingPatients with renal failure had more often hypertension and dyslipidemia than patients with normal renal function (p<0.001 and p=0.01 respectively).21267820
Hypertension, CTCAE, Kidney Failure, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia should be carefully treated to prevent or delay the evolution to the renal failure.21267820
Coronary angiography, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingA propensity score matching for angiographic coronary stenosis severity, heart rate, the presence of arterial hypertension and dyslipidaemia was performed using CAD patients of the institutional CFI database (n = 1076) as the control group.21270076
Nonalcoholic Steatohepatitis, Hyperinsulinism, Fatty degeneration, HepatitisDeregulated Nutrient SensingHepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C. Fatty acid translocase CD36 (FAT/CD36) mediates uptake and intracellular transport of long-chain fatty acids in diverse cell types.21270117
Fatty Liver, Hyperinsulinism, Fatty degeneration, Fatty Liver DiseaseDeregulated Nutrient SensingHepatic FAT/CD36 upregulation is significantly associated with insulin resistance, hyperinsulinaemia and increased steatosis in patients with NASH and HCV G1 with fatty liver.21270117
Diabetes MellitusDeregulated Nutrient SensingGenetic defects in human pericentrin are associated with severe insulin resistance and diabetes.21270239
Prediabetes syndromeDeregulated Nutrient SensingSevere insulin resistance and premature diabetes are common features of PCNT deficiency but are not congenital.21270239
DyslipidemiasDeregulated Nutrient SensingInsulin resistance has been reported to be associated with development of atherogenic dyslipidemia.21270325
Dyslipidemias, ObesityDeregulated Nutrient SensingHowever, the confounding effects that obesity and low levels of cardiorespiratory fitness have on the relationship between insulin resistance and the development of atherogenic dyslipidemia remain to be adequately addressed.21270325
HIV InfectionsDeregulated Nutrient SensingWe report a case of type B insulin resistance syndrome in a patient with HIV infection on highly active antiretroviral therapy (HAART).21270328
HIV InfectionsDeregulated Nutrient SensingA 27-yr-old African woman with ketosis-prone diabetes and HIV infection developed severe insulin resistance after the initiation of HAART.21270328
Immune Reconstitution Inflammatory SyndromeDeregulated Nutrient SensingWe report the first case of type B insulin resistance syndrome associated with immune reconstitution inflammatory syndrome in an HIV-infected patient.21270328
Ovarian CarcinomaDeregulated Nutrient SensingPrognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics.21271224
ovarian neoplasm, NeoplasmsDeregulated Nutrient SensingRecent studies in cell culture models have shown that the growth of tumor cell lines was inhibited by AMPK activation, but the expression of AMPK in human ovarian tumors has not been reported so far.21271224
Ovarian Serous Adenocarcinoma, NeoplasmsDeregulated Nutrient SensingDecreased AMPK expression correlated significantly with higher tumor grade (p=0.009) and was of adverse prognosis in patients with advanced tumor stages (p=0.016) as well as in patients with serous ovarian carcinomas (p=0.037).21271224
ovarian neoplasmDeregulated Nutrient SensingOur results indicate a role for AMPK in progression of ovarian tumors and point towards a prognostic impact of AMPK expression for patient overall survival.21271224
Malignant neoplasm of ovaryDeregulated Nutrient SensingFurthermore, our data suggest a deregulation of the AMPK-dependent energy metabolism in human ovarian carcinomas.21271224
Ovarian Carcinoma, NeoplasmsDeregulated Nutrient SensingIn future clinical studies, activation of AMPK in ovarian carcinoma patients with advanced tumor stages might be an interesting therapeutic approach.21271224
Glucose Intolerance (disease), Fibrosis AssessmentDeregulated Nutrient SensingGlucose intolerance is common in cystic fibrosis (CF), and is associated with worsening pulmonary function and nutritional status, and increased mortality.21273357
Diabetes MellitusDeregulated Nutrient SensingThis case illustrates that CGL should be in the differential diagnosis for non-obese patients with diabetes and insulin resistance.21274320
ObesityDeregulated Nutrient SensingChildhood obesity is associated with an increased risk for insulin resistance.21274322
ObesityDeregulated Nutrient SensingSince gender, obesity and pubertal status are factors affecting insulin resistance, cut-off values which depend on gender and pubertal status, should be used in evaluation of insulin resistance.21274322
Adipose tissue loss, DiseaseDeregulated Nutrient SensingLipodystrophies are a group of diseases characterized by loss of fat tissue and are associated with insulin resistance.21274335
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is an escalating health problem that is frequently associated with obesity and insulin resistance.21274868
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingThe mechanistic relationship between NAFLD, obesity, and insulin resistance is not well understood.21274868
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, diabeticDeregulated Nutrient SensingDiabetic patients were more often women (42.1% vs 23.1%) and presented a higher prevalence of systemic hypertension, dyslipidemia and family history of coronary artery disease.21276955
Quadriplegia, DyslipidemiasDeregulated Nutrient SensingSafety, tolerance, and efficacy of extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia: a randomized multicenter controlled trial.21276961
Quadriplegia, DyslipidemiasDeregulated Nutrient SensingTo test the safety, tolerance, and efficacy of extended-release niacin monotherapy on dyslipidemia in persons with chronic tetraplegia.21276961
Dyslipidemias, Cerebral InfarctionDeregulated Nutrient SensingThe effects of the EPA treatment on ADMA in patients in the chronic phase of cerebral infarction accompanied by dyslipidemia were investigated.21277225
DyslipidemiasDeregulated Nutrient SensingStudy subjects were individuals with either atherothrombotic or lacunar cerebral infarction in the chronic phase accompanied by dyslipidemia, of which the onset was at least 4 weeks earlier.21277225
HyperlipidemiaDeregulated Nutrient SensingRisk factors such as hyperlipidemia, impaired glucose tolerance, and insulin resistance have become common.21277230
Obesity, Diabetes MellitusDeregulated Nutrient SensingIn age-group stratified analysis, there were no significant associations of insufficient sleep or sleep duration with obesity, diabetes status, or insulin resistance after adjustment for age, race/ethnicity, and gender.21278167
Hypertension, CTCAE, Cerebral Infarction, DyslipidemiasDeregulated Nutrient SensingThe common risk factors were hypertension (80.3%), dyslipidemia (56.6%), and multiple cerebral infarction (39.9%).21280516
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingHowever, the patients who had dyslipidemia had risk of microalbuminuria 1.784 times of who did not, but no statistically significant (95% CI, 0.79-4.03; p-value > 0.05).21280516
Non-alcoholic Fatty Liver Disease, AtherosclerosisDeregulated Nutrient SensingAssociation of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study.21281435
AtherosclerosisDeregulated Nutrient SensingThis analysis was conducted in the Insulin Resistance Atherosclerosis (IRAS) Family Study.21281435
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear.21282362
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) and cardiovascular disease may share a common genetic background.21282363
Autoimmune Disorder, CTCAEDeregulated Nutrient SensingThe type B insulin resistance syndrome, a rare autoimmune disorder, is caused by the autoantibodies to the insulin receptor.21284281
HypogonadismDeregulated Nutrient SensingHypogonadism in men is associated with insulin resistance, elevations in pro-inflammatory cytokines and fibrinogen, and an atherogenic lipid profile.21285084
DyslipidemiasDeregulated Nutrient SensingThe lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses.21286016
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingIn conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.21286016
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingOral glucose test revealed glucose intolerance and hormonal investigation discovered hyperinsulinemia and elevated level of FSH.21288754
ImpairedDeregulated Nutrient SensingImpaired muscle capillarization and reduced nutrient exposure to the metabolizing tissue may play a major role in the progression of insulin resistance across the glucose tolerance continuum, independent of age, adiposity, lipid status, and resting energy metabolism.21289242
Glucose Intolerance (disease)Deregulated Nutrient SensingReduced tissue nutrient exposure may aid in the progression of glucose intolerance.21289242
Communicable Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTherefore intensive management of risk factors (hypertension, diabetes and dyslipidaemia) and prompt recognition of infection is hereby recommended.21291114
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDecreased incretin secretion seems to develop early in the course of type 2 diabetes with increasing insulin resistance, but not to be influenced by glycaemic status.21292338
Calcification of coronary artery, AtherosclerosisDeregulated Nutrient SensingThe relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA).21292863
Calcification of coronary artery, SLC25A20 geneDeregulated Nutrient SensingWe sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC).21292863
Chronic Kidney DiseasesDeregulated Nutrient SensingIs insulin resistance a risk factor for the progression of chronic kidney disease?21293152
Glucose Intolerance (disease), Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe prevalence of overweight-obesity (41.8% vs. 25.5%, p = 0.038), IR (42.9% vs. 23.5%, p = 0.035) and glucose intolerance (15.38% vs. 1.96%, p = 0.043) were significantly higher in PCOS compared to control group.21294689
Inflammation, Prostate Cancer Outcomes Study, Dyslipidemias, HyperandrogenismDeregulated Nutrient SensingPCOS was found to be associated with dyslipidemia, hyperandrogenism, IR and sub-clinical inflammation.21294689
IFNG wt Allele, Hyperglycemia, Dyslipidemias, Obesity, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity, hyperglycemia, and dyslipidemia were prevalent and increased from NFG to IFG and T2D.21298483
Diabetes MellitusDeregulated Nutrient SensingRelationship between erythropoietin responsiveness, insulin resistance, and malnutrition-inflammation-atherosclerosis (MIA) syndrome in hemodialysis patients with diabetes.21298620
Syndrome, diabeticDeregulated Nutrient SensingDiabetic hemodialysis patients with MIA syndrome have a lower response to EPO and a higher resistance to insulin.21298620
Glucose Intolerance (disease)Deregulated Nutrient SensingThese results suggest a different natural history to respect glucose intolerance.21300382
Glucose Intolerance (disease), Congestive heart failureDeregulated Nutrient SensingGlucose intolerance is recognized as a predictor of congestive heart failure (CHF).21300789
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingTwo hundred and eighty-seven Japanese subjects who visited the university hospital to be checked for glucose intolerance or known type 2 diabetes were consecutively recruited.21300789
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe found prevalence rates of 26%, 48%, and 13% for hypertension, dyslipidemia, and diabetes, respectively.21302140
Complications of Diabetes Mellitus, diabeticDeregulated Nutrient SensingElevated plasma levels of asymmetric dimethylarginine (ADMA) has been reported to be associated with insulin resistance and micro/macrovascular diabetic complications, and may predict cardiovascular events in type 2 diabetic patients.21303562
Weakness, Dyslipidemias, Prostate carcinomaDeregulated Nutrient SensingA 64-year-old man who received ketoconazole for prostate cancer, along with simvastatin and fenofibrate for dyslipidemia, presented to our ambulatory clinic with complaints of blood in his urine and weakness following an increase in his ketoconazole dose.21304039
NeoplasmsDeregulated Nutrient SensingThe patient was treated with mammalian target of rapamycin complex 1 (mTORC1) inhibitors, but after 5 months the tumor had progressed.21304509
Hereditary Leiomyomatosis and Renal Cell Cancer, Renal Cell Carcinoma, Family history, FH wt AlleleDeregulated Nutrient SensingpRCC-2 arising in a patient with a novel germline FH mutation and de novo hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome progressing after mTORC1 inhibitor therapy.21304509
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingBoth altered sympathetic function and insulin resistance have been observed in amyotrophic lateral sclerosis (ALS).21305564
Glucose Intolerance (disease), Prediabetes syndromeDeregulated Nutrient SensingThe index date was the first pre-diabetes diagnosis (ICD-9 codes 790.21, 790.22, 790.29) or qualifying lab value of fasting plasma glucose or impaired glucose intolerance.21306287
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingMagnesium levels did not differ between women with and those without insulin resistance, glucose intolerance, or hypertension.21306320
Primary malignant neoplasmDeregulated Nutrient SensingSirT1 brings stemness closer to cancer and aging.21307403
Primary malignant neoplasmDeregulated Nutrient SensingSirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated.21307403
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn patients attended in PC (67% treated with antihypertensive drugs, 31% with BP < 140/90 mmHg, 22% with dyslipidemia and 16% with diabetes), added global CV risk was average or low in 26%, moderate in 31%, high in 27% and very high in 16%; in patients attended in HC (77% treated with antihypertensive drugs, 16% with BP <140/90 mmHg, 47% with dyslipidemia and 26% with diabetes), added global CV risk was average or low in 16%, moderate in 30%, high in 28% and very high in 26%.21309358
AHSG protein, humanDeregulated Nutrient SensingFetuin-A is an important player in the enhancement of insulin resistance.21310413
Inflammation, ObesityDeregulated Nutrient SensingAssociation between obesity history and hand grip strength in older adults--exploring the roles of inflammation and insulin resistance as mediating factors.21310808
Inflammation, ObesityDeregulated Nutrient SensingTo examine the association between obesity history and hand grip strength, and whether the association is partly explained by subclinical inflammation and insulin resistance.21310808
Impulsive BehaviorDeregulated Nutrient SensingExcess body fat has been linked to impaired glucose metabolism, insulin resistance, and impulsivity and may be a precursor to decline in attention and executive cognitive function.21311507
DyslipidemiasDeregulated Nutrient SensingThe combination of Pio with SU or Met may therefore be recommended for T2D second-line therapy in the routine clinical practice, particularly in patients with dyslipidemia.21314919
Dyslipidemias, ConsensusDeregulated Nutrient SensingFor the entire group, dyslipidemia, TransAtlantic InterSociety Consensus II C and D lesions, and angioplasty without stenting negatively affected primary patency.21315232
NeoplasmsDeregulated Nutrient SensingIt has been suggested that adenosine monophosphate-activated protein kinase (AMPK) and 12 AMPK-related kinases (ARK), including novel (nua) kinase family 1 (NUAK1), are activated by master kinase LKB1, a major tumor suppressor.21317932
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia and undernutrition in children from impoverished areas of Maceio, state of Alagoas, Brazil.21317999
Coronary Artery DiseaseDeregulated Nutrient SensingWe hypothesised that insulin resistance is associated with both angiographically determined coronary artery disease (CAD) and with the MetS.21320476
Retinal DiseasesDeregulated Nutrient SensingSeven hundred men and women from the DESIR (Data From an Epidemiological Study on the Insulin Resistance Syndrome) Study underwent evaluation for retinopathy using a nonmydriatic digital camera.21320965
Hyperglycemia, Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingHyperglycemia, glucose intolerance, hypertension and socioeconomic position in eastern Nepal.21323183
Glucose Intolerance (disease), IFNG wt Allele, Diabetes MellitusDeregulated Nutrient SensingOf urban participants (n = 736) with no history of diabetes 70 (9.5%) had HGY and 143 (19.4%) had glucose intolerance (IFG and IGT).21323183
Hyperglycemia, Glucose Intolerance (disease)Deregulated Nutrient SensingBoth urban and rural populations are at risk for hyperglycemia and glucose intolerance.21323183
Diabetes MellitusDeregulated Nutrient SensingParticipants in this sample had insulin resistance, a potent predictor of diabetes.21324254
Malignant neoplasm of endometriumDeregulated Nutrient SensingProspective evaluation of insulin resistance among endometrial cancer patients.21324431
Diabetes MellitusDeregulated Nutrient SensingWhereas diabetes also increases the risk, little is known about related insulin resistance (IR).21324431
HypothyroidismDeregulated Nutrient SensingThe primary outcome was progression to overt hypothyroidism, with secondary outcome measures of blood pressure, insulin resistance, lipids, and highly sensitive C-reactive protein (hsCRP).21325465
Primary malignant neoplasmDeregulated Nutrient SensingMutations in growth signaling pathways extend life span, as well as protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice.21325617
Weight decreasedDeregulated Nutrient SensingEffects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.21327867
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, increased muscle (hepatically derived) TAG extraction during postprandial conditions and increased saturation of intramuscular DAG are associated with insulin resistance, suggesting that disturbances in skeletal muscle FA handling could play a role in the development of whole body insulin resistance and type 2 diabetes.21331063
Diabetic Nephropathy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results indicate that SIRT1 may play a role in susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.21331741
Hypertensive (finding)Deregulated Nutrient SensingWe conclude that training determined BP and insulin resistance reduction in SHR, and increased GLUT4 expression in both normotensive and hypertensive rats.21332027
HD Term Type, DyslipidemiasDeregulated Nutrient SensingThe association between lipid profiles of 180 CAPD patients and glucose-containing dialysate was analyzed using Pearson methods; 76.56% of NT patients, 66.13% of HD patients, and 72.22% of CAPD patients had dyslipidemia.21332332
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingIn addition, the results of our investigation, also, demonstrate that the significant correlation between higher percentage of a.s. PSA and the occurrence of NSTEMI persisted after adjustment for traditional CAD risk factors (age, DM, dyslipidemia, and smoking).21333366
Dyslipidemias, Sleep Apnea, Obstructive, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingHowever, 83%, 87%, 67%, and 76% of patients with diabetes, hypertension, dyslipidemia, and obstructive sleep apnea, respectively, experienced improvement or resolution.21333610
Peripheral Vascular Diseases, One Vessel Coronary Disease, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe percentage of patients with dyslipidemia, hypertension, triple vessel disease, peripheral vascular disease, and left main disease increased over time (P < .05).21334012
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe report the effects of high-dose atorvastatin therapy on cerebral vasomotor reactivity (VMR) in patients with controlled hypertension and dyslipidemia.21334223
Hypertension, CTCAE, Ischemic stroke, DyslipidemiasDeregulated Nutrient SensingThe majority (61%) had suffered an ischemic stroke and 97.7% presented at least one associated cardiovascular risk factor, being hypertension (84.8%) and dyslipidemia (61.8%) the most frequent.21334698
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation between insulin resistance and development of microalbuminuria in type 2 diabetes: a prospective cohort study.21335369
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAn association between insulin resistance and microalbuminuria in type 2 diabetes has often been found in cross-sectional studies.21335369
Diabetes MellitusDeregulated Nutrient SensingLow 25-OH-D, common in the paediatric population at risk for diabetes (older children, African-Americans, children with increasing BMI-Z) is associated with worse insulin resistance.21335626
Degenerative polyarthritisDeregulated Nutrient SensingPotential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions.21337390
Degenerative polyarthritisDeregulated Nutrient SensingNevertheless, the role of SIRT1 in the pathogenesis of osteoarthritis (OA) is still unknown.21337390
Degenerative polyarthritis, HypertrophyDeregulated Nutrient SensingOur observations suggest that SIRT1 expression decreases with development of OA and the reduction of SIRT1 in chondrocytes may cause chondrocyte hypertrophy and cartilage matrix loss.21337390
Degenerative polyarthritisDeregulated Nutrient SensingSIRT1 might play important roles in the pathogenesis of OA.21337390
glycationDeregulated Nutrient SensingSerum advanced glycation end products (AGEs) are associated with insulin resistance.21337488
glycationDeregulated Nutrient SensingWe have demonstrated that the circulating level of advanced glycation end products is associated with insulin resistance even in non-obese, non-diabetic subjects independent of adiponectin.21337488
Psoriatic Juvenile Idiopathic Arthritis, Inflammation, DyslipidemiasDeregulated Nutrient SensingOn this background we have conducted a pilot study to explore the hypothesis that this modified fatty acid could improve dyslipidemia and reduce inflammation in psoriatic patients.21338276
Ischemia, Guinea (geographic area)Deregulated Nutrient SensingThe AMPK activity remained unchanged during ischemia in the GIN group, whereas it increased in the control group (P < 0.05).21346060
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCompared to other indices of insulin resistance HbA1c has minimal overlap in values (0.0%) between NGT and subjects with type 2 diabetes.21348785
Glucose Intolerance (disease), Dyslipidemias, ObesityDeregulated Nutrient SensingOffspring of type 2 diabetics have an increased risk of dyslipidemia, glucose intolerance and obesity.21349807
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingType 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease.21354969
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register.21354969
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingThe distribution of blood lipids in this large sample of unselected type 2 diabetic patients challenges the previous conception of diabetic dyslipidemia, and calls for new studies to explain the roles of LDL-C and HDL-C as strong cardiovascular risk factors in type 2 diabetes.21354969
Heat-Shock ResponseDeregulated Nutrient SensingTDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling.21355045
Nerve DegenerationDeregulated Nutrient SensingThese results suggest that protein misfolding underlies the aging-dependent neurodegeneration associated with TDP-43 and that the insulin/IGF-1 signaling may be a target for therapies.21355045
Dyslipidemias, Lupus NephritisDeregulated Nutrient SensingThere is little data on the prevalence and severity of dyslipidaemia in Asian patients with lupus nephritis (LN).21355950
Renal Insufficiency, DyslipidemiasDeregulated Nutrient SensingWhether the dyslipidaemia in LN patients differs from subjects with comparable levels of renal impairment also remains undefined.21355950
Proteinuria, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia is prevalent in LN patients and is more severe than controls with a similar degree of CKD despite disease quiescence, low steroid dose and low level of proteinuria.21355950
Dyslipidemias, diabeticDeregulated Nutrient SensingWe used the Discriminant Ratio (DR) methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation.21356116
Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingWe observed no significant association between AMPK genotype and pancreatic cancer and no genotype interactions with diabetes or smoking.21357378
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingReduced levels of total osteocalcin (TOC) are associated with adiposity, insulin resistance and type 2 diabetes, implying this bone-derived peptide might modulate cardiovascular risk.21359669
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingTwenty-eight children had hypercholesterolemia, and 11 had other forms of dyslipidemia.21359948
AtherosclerosisDeregulated Nutrient SensingDecreased adiponectin level, the adipose tissues hormone, is related to high body mass and insulin resistance, which are risk factors for atherosclerosis.21360915
Dyslipidemias, ObesityDeregulated Nutrient SensingObesity plays a critical role in dyslipidemia and related disorders.21361295
Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study was designed to investigate the prevalence of type 2 diabetes mellitus and insulin resistance, and to explore the relation between insulin resistance and hepatitis C virus genotype, serum hepatitis C virus-RNA level in chronic hepatitis C (CHC) patients.21362362
Carcinogenic Chlorinated Hydrocarbon, Complete atrioventricular blockDeregulated Nutrient SensingInsulin resistance was less frequent in CHB than in matched CHC (7.9% vs. 21.4% respectively, P < 0.0001).21362362
Hypertensive (finding)Deregulated Nutrient SensingElevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats.21365528
Complication Aspects, DyslipidemiasDeregulated Nutrient SensingChildren presented a higher prevalence of insulin resistance and dyslipidaemia compared with adolescents, suggesting that ART, especially PIs, may lead to metabolic complications.21371728
Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance in renal transplant recipients is associated with increased urinary albumin excretion.21376123
Glucose Intolerance (disease), AlbuminuriaDeregulated Nutrient SensingThese results indicated that glucose intolerance is associated with increased albuminuria in renal transplant recipients.21376123
Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingHigh rates of dyslipidemia and insulin resistance (IR) are reported in patients with bipolar disorder (BD).21377167
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingShort-term RSG therapy reduced insulin resistance, in vivo markers of inflammation and abnormal endothelial function but had no effect on arterial function and stiffness in patients with CKD.21378155
Hypodynamia, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIt was shown that the proposed approach allows a few risk factors (dyslipidemia, hypodynamia, arterial hypertension, smoking, and obesity) to be simultaneously corrected.21381320
Prostate Cancer, Hereditary, 7, Obesity, Visceral, ObesityDeregulated Nutrient SensingAlthough many case-control studies have associated obesity to prostate cancer aggressiveness, few have correlated markers of prostate pathology to biomarkers of visceral obesity and insulin resistance, using an apparently healthy cohort.21382022
Steatohepatitis, Fibrosis Assessment, Hepatitis C, Hepatitis, ChronicDeregulated Nutrient SensingHepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection.21382161
Carcinogenic Chlorinated Hydrocarbon, Fatty degeneration, Hepatitis C, ChronicDeregulated Nutrient SensingSteatosis and insulin resistance (IR) are the major disease modifying in patients with chronic hepatitis C (CHC).21382161
Malignant tumor of colon, InflammationDeregulated Nutrient SensingAdditional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.21383385
ETV3 wt AlleleDeregulated Nutrient SensingThe diagnostic accuracy of these values in identifying MetS was similar to that of insulin resistance.21384232
Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Musculoskeletal Diseases, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity is a major risk factor for developing type 2 diabetes, cardiovascular disease, hypertension, dyslipidemias, musculoskeletal diseases, and certain types of cancer.21384636
MyocardialDeregulated Nutrient SensingThe hexosamine biosynthetic pathway can mediate myocardial apoptosis in a rat model of diet-induced insulin resistance.21385329
Fatty infiltrationDeregulated Nutrient SensingThe state of insulin resistance (calculated by HOMA-IR and WBISI) deteriorated as the degree of fatty infiltration increased.21390143
Dyslipidemias, physiopathological, Diabetes MellitusDeregulated Nutrient SensingRisk factors for microvascular dysfunction include dyslipidemia, smoking and diabetes.21391731
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingResidual risk persists despite aggressive low-density lipoprotein cholesterol (LDL-C) reduction in patients with atherosclerotic cardiovascular (CV) disease, many of whom have atherogenic dyslipidemia (low levels of high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, and small dense LDL particles).21392609
Dyslipidemias, ciliary vesicleDeregulated Nutrient SensingAll study participants had established CV disease and atherogenic dyslipidemia.21392609
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingAIM-HIGH enrolled a high-risk group of patients with established atherosclerotic CV disease and atherogenic dyslipidemia.21392609
Heart Diseases, Diastolic dysfunction, Bortezomib/Dexamethasone/Pegylated Liposomal Doxorubicin RegimenDeregulated Nutrient SensingAbnormal left ventricular (LV) structure and diastolic function are frequently detected in a variety of heart diseases, and insulin resistance has been suggested to be associated with LV diastolic dysfunction (LVDD).21392830
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingMentions of obesity, dyslipidemias, hypertension, and diabetes mellitus increased significantly.21393588
Prostate carcinoma, ObesityDeregulated Nutrient SensingStudies have linked prostate cancer risk with insulin resistance and obesity.21397927
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia, a major cardiovascular risk factor has been reported to predate the onset of RA, thus suggesting a potential genetic link between the two conditions.21398331
DyslipidemiasDeregulated Nutrient SensingImpact of optimal lipid value achievement between 2005 and 2009 in patients with mixed dyslipidaemia on cardiovascular event rates.21401832
Dyslipidemias, Coronary Arteriosclerosis, Primary hypercholesterolemia, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIn patients with primary hypercholesterolemia or mixed dyslipidemia, extended-release niacin/laropiprant (ERN/LRPT) improves key lipid parameters associated with increased atherosclerotic coronary heart disease (CHD) risk.21401833
Diabetes MellitusDeregulated Nutrient SensingLipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.21403394
Diabetes MellitusDeregulated Nutrient SensingLevels of TAGs associated with increased risk for diabetes decreased in response to insulin action and were elevated in the setting of insulin resistance.21403394
Diabetes MellitusDeregulated Nutrient SensingConversely, levels of TAGs associated with decreased diabetes risk rose in response to insulin and were poorly correlated with insulin resistance.21403394
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia is an independent risk factor for type 2 diabetes, although exactly which of the many plasma lipids contribute to this remains unclear.21403394
Steatohepatitis, Diabetes MellitusDeregulated Nutrient SensingIn chronic hepatitis C, insulin resistance, type 2 diabetes and liver steatosis are frequent and inconsistently correlated to circulating resistin levels.21410061
diabeticDeregulated Nutrient SensingAssociation between improvements in insulin resistance and changes in cognitive function in elderly diabetic patients with normal cognitive function.21410855
Mental deterioration, Diabetes MellitusDeregulated Nutrient SensingSeveral studies have shown that diabetes is a risk factor for declines in cognitive function and, recently, numerous studies have demonstrated that exercise improves insulin resistance (IR).21410855
Steatohepatitis, Non-alcoholic Fatty Liver Disease, AtherosclerosisDeregulated Nutrient SensingInsulin resistance has an important role in the development of nonalcoholic fatty liver disease (NAFLD) and is involved in both pathological processes: hepatic steatosis and atherosclerosis.21411114
Diabetes Mellitus, Non-Insulin-Dependent, Sleep disturbances, Diabetes MellitusDeregulated Nutrient SensingThe observed association between poor sleep quality and higher glucose, insulin, and estimated insulin resistance among subjects with diabetes warrants further examination of the effect of sleep disturbances on glucose control in type 2 diabetes.21411507
macroangiopathy, Dyslipidemias, Disease of capillaries, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia and a high body mass index were significantly associated with macroangiopathy, while diabetes of long duration and a high concentration of HbA1c were associated with microangiopathy.21411989
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAlso, Arabs were more likely to be obese (OR = 1.72; 95% CI: 1.19-2.50) and have diabetes (OR = 1.41; 95% CI: 1.01-1.96), while Jews were more likely to have dyslipidemia (OR = 1.56; 95% CI: 1.11-2.17).21411992
Breast Carcinoma, ObesityDeregulated Nutrient SensingHigh circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC).21413010
HyperglycemiaDeregulated Nutrient SensingThe results of this study add to the existing epidemiological evidence that hyperglycemia and insulin resistance increase BC risk.21413010
Alopecia, CTCAEDeregulated Nutrient SensingAndrogenetic alopecia and insulin resistance: are they truly associated?21413951
Androgenetic AlopeciaDeregulated Nutrient SensingControversies exist regarding the association of androgenetic alopecia (AGA) with insulin resistance.21413951
Non-alcoholic Fatty Liver Disease, Colorectal CarcinomaDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of insulin resistance (IR), and IR is associated with an increased risk of colorectal carcinoma (CRC).21414047
Steatohepatitis, Glucose Intolerance (disease), Adenoma of large intestineDeregulated Nutrient SensingMultivariate regression analyses demonstrated an independent association of colorectal adenomas with hepatic steatosis after adjustment for age, sex, body mass index and glucose intolerance (OR 1.47; 95% CI 1.079-2.003; P = 0.015).21414047
Inflammation, Malignant neoplasm of endometrium, ObesityDeregulated Nutrient SensingThe association between obesity and endometrial cancer risk in postmenopausal women may be attributed to inflammation, insulin resistance, and elevated estrogen.21415362
methionineDeregulated Nutrient SensingAffymetrix 133v2 arrays identified GMNN, MET, CCNE2, SIRT1 and CDK6 as miR-449 targets.21418558
methionineDeregulated Nutrient SensingLuciferase assays were used to confirm GMNN, MET, CCNE2 and SIRT1 as direct targets.21418558
Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCoronary plaques were more frequent in patients with stroke, diabetes, hypertension, and dyslipidemia than in patients without these conditions (all p values <0.001).21420050
Dyslipidemias, HypertrophyDeregulated Nutrient SensingVisceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women.21421806
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAll analyses were adjusted for age, education, living arrangements, Duke Social Support grouping, smoking, and history of diabetes, hypertension, and dyslipidemia.21422905
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingEighty-three percent of patients received the recommended care for cardiovascular risk factors, including >75% for hypertension, dyslipidemia and diabetes.21424868
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe overall risk of developing diabetes mellitus and glucose intolerance seems to be higher in women with polycystic ovary syndrome (PCOS) than in healthy women.21427116
Inflammation, Dyslipidemias, OverweightDeregulated Nutrient SensingIn this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons.21427737
Hyperhomocysteinemia, Metabolic Syndrome XDeregulated Nutrient SensingSeveral observations suggest that there might be links between hyperhomocysteinemia and insulin resistance, its clinical surrogate of metabolic syndrome.21428179
Fatty Liver DiseaseDeregulated Nutrient SensingThe mechanism by which iron load induces insulin resistance is possibly independent of the pathways involved in insulin resistance induced by fatty liver disease.21430023
Carcinoma of lungDeregulated Nutrient SensingThe impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival.21430184
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingThe aim of this study is to investigate the prognostic role of phosphorylated AMP-activated protein kinase (pAMPK) in surgically resected non-small-cell lung cancer (NSCLC).21430184
Carcinoma of lungDeregulated Nutrient SensingOur results support further evaluation of AMP-activated protein kinase as a potential prognostic and therapeutic target for lung cancer.21430184
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAn increase in the proportion of hypertension and dyslipidemia awareness, treatment, and control in all educational level groups was observed.21435903
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe diagnosis is clinical and there is no treatment for it but recognition is necessary to minimize early atherosclerosis through the control of dyslipidemia.21437546
OsteoporosisDeregulated Nutrient SensingSerum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study.21437719
DyslipidemiasDeregulated Nutrient SensingIn the KDM group 63% had dyslipidaemia (low HDL cholesterol or elevated triglycerides) vs. 80% in the SDM group, p = 0.32.21438763
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIn the long term, smoking and dyslipidemia were the main predictors of CKD.21440776
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance (IR) is highly prevalent in chronic hemodialysis (CHD) patients and is associated with poor cardiovascular outcomes.21441124
ObesityDeregulated Nutrient SensingIdentification and functional characterization of a missense mutation in resistin in two patients with severe obesity and insulin resistance.21441316
ObesityDeregulated Nutrient SensingRetinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance.21442217
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes.21442217
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImprovement of insulin resistance and reduction of cardiovascular risk among obese patients with type 2 diabetes with the duodenojejunal bypass liner.21442376
Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThe DJBL, when used for a period of 6 months, is effective in the control of diabetes, weight loss, improvement of insulin resistance, and decrease of cardiovascular risk among morbidly obese patients with type 2 diabetes mellitus.21442376
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia is one of the primary causes for coronary artery disease (CAD).21446364
Fatty Liver DiseaseDeregulated Nutrient SensingThere was no significant effect of insulin resistance and NASH on whole body rate of protein turnover [phenylalanine Ra (rate of appearance)] and on the rate of urea synthesis.21446920
Autoimmune Diseases, ObesityDeregulated Nutrient SensingData collection and analyses will focus on determining the phenotype of islet autoimmunity, genotypes of T1D- and type 2 diabetes-associated genes, insulin resistance, and b-cell function, growth, obesity, and physical exercise.21446926
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingHuman resistin is an adipokine, with a possible link to coronary heart disease, and the relationship between serum resistin, insulin resistance, and type 2 diabetes mellitus (T2DM) remains controversial.21447495
Breast CarcinomaDeregulated Nutrient SensingSeveral in vitro studies have suggested the effects of adipokines and insulin resistance on breast cancer cell proliferation and survival.21450081
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingOf PCOS features, an elevated free T level was most predictive of insulin resistance.21450287
Irregular MenstruationDeregulated Nutrient SensingMenstrual irregularity and polycystic ovary morphology were not associated with insulin resistance (56.3% vs. 52.9% and 60.0% vs. 34.4%, respectively).21450287
DyslipidemiasDeregulated Nutrient SensingResults suggest that residual dyslipidemia in statin-treated patients at low cardiovascular risk may be reduced by increasing statin dose.21450578
diabeticDeregulated Nutrient SensingIn asymptomatic and fairly controlled diabetic patients, age, worse HbA1c, traits of insulin resistance, such as visceral adiposity and triglycerides or treatment with metformin, and use of doxazosin indicate greater risk of LVD.21450640
Electrocardiogram abnormal, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe following risk factors were independent predictors of electrocardiographic abnormalities: male gender (P = .006), diabetes mellitus (P = .0001), and dyslipidemia (P = .001).21453931
Celiac Disease, Dyslipidemias, Liver DysfunctionDeregulated Nutrient SensingBefore 2007, none of the patients had screening performed for celiac disease, dyslipidemia, or liver dysfunction, and none had routine electrocardiography or cardiac magnetic resonance imaging.21454226
Celiac Disease, Dyslipidemias, Congenital AbnormalityDeregulated Nutrient SensingSince 2007, 63% were screened for celiac disease, 54% for liver abnormalities, and 38% for dyslipidemia.21454226
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study.21455728
DyslipidemiasDeregulated Nutrient SensingPIOfix-study: effects of pioglitazone/metformin fixed combination in comparison with a combination of metformin with glimepiride on diabetic dyslipidemia.21457065
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia in patients with type 2 diabetes is characterized by elevated triglyceride levels, decreased high-density lipoprotein (HDL) cholesterol, and a predominance of small dense low-density lipoprotein (LDL) particles.21457065
Depressed mood, Polycystic Ovary SyndromeDeregulated Nutrient SensingElevated levels of plasma homocysteine and depressed ghrelin levels have been found to be associated with insulin resistance in a number of clinical situations, such as polycystic ovary syndrome.21458334
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe management of cardiovascular risk factors such as hypertension and dyslipidemia is poorly described in many communities, and the benefits associated with tighter control remain unknown.21459263
Cardiovascular DiseasesDeregulated Nutrient SensingA systematic evaluation of the insulin resistance syndrome as an independent risk factor for cardiovascular disease mortality and derivation of a clinical index.21459390
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance-related risk factor clustering (the insulin resistance syndrome or IRS) may be a cardiovascular disease (CVD) risk factor, but a convincing demonstration of this requires a rigorously derived reference measure and a systematic evaluation of measures and indices that derive from that measure.21459390
Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingLymphotoxin-a 252 A>G polymorphism: a link between disease susceptibility and dyslipidemia in rheumatoid arthritis?21459939
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThe LTA 252 A/A genotype translates to a phenotype more prone to dyslipidemia, and the G/G genotype to a phenotype with earlier onset of disease and higher levels of CRP, when RA does occur.21459939
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThese observations highlight a possible common genetic predisposition to RA and dyslipidemia.21459939
melanomaDeregulated Nutrient SensingWe used a public array comparative genomic hybridization (CGH) database and real-time quantitative PCR (qPCR) analyses to identify the AMP kinase (AMPK)-related kinase NUAK2 as a candidate gene for melanomagenesis, and we analyzed its functions in melanoma cells.21460252
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingThis study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties.21460252
Dyslipidemias, Hypertension, CTCAE, Endothelial dysfunction, Obesity, VisceralDeregulated Nutrient SensingHypertension in postmenopausal women are usually associated with other cardiovascular risk factors, such as dyslipidemias, visceral obesity and endothelial dysfunction.21463249
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingMajority of patients were males, associated with dyslipidaemia, hypertension and smoking.21465976
Weight decreasedDeregulated Nutrient SensingInsulin resistance influences weight loss in non-obese women who followed a home-based exercise program and slight caloric restriction.21466903
Non-insulin Hypoglycemic, Weight decreasedDeregulated Nutrient SensingInsulin resistance facilitated weight loss, and home-based exercise promoted greater weight loss only in non-insulin resistance women.21466903
Weight GainDeregulated Nutrient SensingEarly effects of smoking cessation and weight gain on plasma adiponectin levels and insulin resistance.21467702
Weight GainDeregulated Nutrient SensingAim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance.21467702
Electrocardiogram: myocardial infarction (finding), DyslipidemiasDeregulated Nutrient SensingDyslipidemia is an important risk factor for myocardial infarction (MI).21468600
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome.21469322
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes.21470285
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThere is a high prevalence of low testosterone and dyslipidaemia in men with type 2 diabetes.21470285
Primary malignant neoplasmDeregulated Nutrient SensingCancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.21471201
Dyslipidemias, Atherosclerosis, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of airflow obstruction in patients with atherosclerosis (29.3%) was greater than that in patients with dyslipidemia (24.3%), diabetes mellitus (23.1%) or hypertension (27.1%).21473425
ObesityDeregulated Nutrient SensingThe observed increase of triglycerides after glucose load in subjects with signs of insulin resistance and obesity suggests that post-glucose triglyceride change is a potential novel biomarker for early detection of metabolic risk.21474138
Steatohepatitis, Obesity, AbdominalDeregulated Nutrient SensingThe specific association of post-glucose triglyceride change with abdominal obesity and fasting glucose suggests a link to hepatic steatosis and insulin resistance.21474138
Hypertensive (finding), Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe most prevalent cardiovascular risk factor was dyslipidaemia, found in 80.4% (37.9% with treatment), followed by abdominal obesity, in 45.9% of the hypertensive patients.21474438
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients referred from the ED were less likely to have a diagnosis of hypertension, dyslipidemia, or diabetes, but were more likely to smoke.21474891
Dyslipidemias, EfficiencyDeregulated Nutrient SensingThese findings suggest that increased muscular efficiency at low exercise intensity and reduced lipid oxidation during rest and exercise may contribute to both dyslipidemia and increased adiposity in individuals with ALP.21475144
Primary Biliary CholangitisDeregulated Nutrient SensingContribution of zinc deficiency to insulin resistance in patients with primary biliary cirrhosis.21476007
No metabolic abnormalitiesDeregulated Nutrient SensingThe relationship between metabolic abnormalities of trace elements and insulin resistance has been established.21476007
Primary Biliary CholangitisDeregulated Nutrient SensingThe purpose of this study was to examine the correlation between zinc or copper metabolism and insulin resistance in patients with primary biliary cirrhosis (PBC).21476007
Fibrosis Assessment, Primary Biliary CholangitisDeregulated Nutrient SensingThese results suggest that zinc deficiency plays important roles of insulin resistance and subsequent hepatic fibrosis in patients with PBC, although insulin resistance in advanced stage PBC was significantly milder than that in HCV-related liver cirrhosis.21476007
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingObesity increases the risk for cardiovascular risk factors (CVRFs), including hypertension, dyslipidaemia and type 2 diabetes.21478001
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingIn men, 37% of dyslipidaemia (30% in women) could be attributed to overweight and obesity; overweight had a higher contribution than obesity in both sexes.21478001
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Overweight, ObesityDeregulated Nutrient SensingOverall, approximately 27,000 cases of type 2 diabetes, 63,000 cases of high blood pressure and 37,000 cases of dyslipidaemia could have been avoided if overweight and obesity levels were maintained at 1992 levels.21478001
diabeticDeregulated Nutrient SensingCharacterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARg mutation (Y151C).21479595
LMNA wt Allele, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn the present study we aimed to identify cases of FPLD among non-obese patients with type 2 diabetes mellitus and marked insulin resistance.21479595
diabeticDeregulated Nutrient SensingWe searched the databases of three diabetic outpatient clinics for patients with marked insulin resistance, arbitrarily defined as the use of >=100 U insulin/day, and BMI <= 27 kg/m(2).21479595
NeoplasmsDeregulated Nutrient SensingResveratrol induces SIRT1- and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment.21479886
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes.21480966
Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingThe aim of this study was to compare the effects of calorie-restricted vegetarian and conventional diabetic diets alone and in combination with exercise on insulin resistance, visceral fat and oxidative stress markers in subjects with Type 2 diabetes.21480966
VisceralDeregulated Nutrient SensingThe greater loss of visceral fat and improvements in plasma concentrations of adipokines and oxidative stress markers with this diet may be responsible for the reduction of insulin resistance.21480966
ObesityDeregulated Nutrient SensingPlasma phospholipid transfer protein activity is independently determined by obesity and insulin resistance in non-diabetic subjects.21481395
Obesity, Diabetes MellitusDeregulated Nutrient SensingElevated plasma PLTP activity levels are reported in obesity and diabetes mellitus, but the relative contributions of obesity and insulin resistance to plasma PLTP activity remain unclear.21481395
ObesityDeregulated Nutrient SensingWe tested whether plasma PLTP activity is independently related to (central) obesity and insulin resistance in non-diabetic subjects.21481395
ObesityDeregulated Nutrient SensingIn non-diabetic subjects, both obesity and insulin resistance influence plasma PLTP activity, resulting in elevated plasma PLTP activity particularly with combined increases in obesity and insulin resistance.21481395
ObesityDeregulated Nutrient SensingHigher PLTP activity could contribute to elevated cardiovascular risk in the presence of obesity and insulin resistance.21481395
Prediabetes syndromeDeregulated Nutrient SensingWe interviewed overweight/obese [Body Mass Index (BMI) >= 85th percentile], 12-18-yr old adolescents with T2DM, prediabetes, or insulin resistance (IR) and a parent.21489091
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus.21489574
Pulmonary arterial hypertension, Polycyclic Hydrocarbons, AromaticDeregulated Nutrient SensingAnimal and human data suggest insulin resistance is common in pulmonary arterial hypertension (PAH).21493097
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingAlthough routine assessment of insulin resistance is difficult, hemoglobin A(1c) (HbA(1c)) is a sensitive test to detect diabetes mellitus (DM) and those at high risk for DM.21493097
Pulmonary arterial hypertension, Glucose Intolerance (disease)Deregulated Nutrient SensingUnrecognized glucose intolerance is common in pulmonary arterial hypertension.21493097
DyslipidemiasDeregulated Nutrient SensingThe present study was conducted to investigate the role of plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels, a regulator of LDL-receptor expression, in the occurrence of diabetic dyslipidemia.21497351
DyslipidemiasDeregulated Nutrient SensingThese observations should be regarded as hypothesis generating for further studies aimed at elucidating the role of PCSK9 in the pathogenesis and treatment of diabetic dyslipidemia.21497351
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingThe following conditions were evaluated: dyslipidemia, systemic arterial hypertension, and type 2 diabetes.21499023
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingPrevalence of dyslipidemia and hyperuricemia were 41.7% and 27.8%, respectively.21499989
Increased insulin level, Fatty replacement of skeletal muscleDeregulated Nutrient SensingHigher concentrations of CRP appear to be associated with greater skeletal muscle AT infiltration, lower subcutaneous AT, hyperinsulinemia, and insulin resistance.21501070
CataractDeregulated Nutrient SensingChanges in SIRT1 expression and its downstream pathways in age-related cataract in humans.21501079
Radiation ArcDeregulated Nutrient SensingThis study was to investigate the expression of SIRT1 in human lens epithelial cells, and to observe the changes in SIRT1 expression and its downstream P53 and forkhead box class O (FOXO) proteins at the onset of ARC.21501079
Radiation ArcDeregulated Nutrient SensingIn contrast, the expression of Bim was lowest in the ARC lens, and TUNEL assay showed significantly increased apoptosis incidence in group C. The expression of SIRT1 increased in ARC in humans.21501079
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, PrehypertensionDeregulated Nutrient SensingCardiovascular disease (CVD) risk, insulin resistance and b-cell function in prehypertension population of China.21501840
Impaired T cell function, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo explore the cardiovascular disease (CVD) risk in prehypertensive subjects and evaluate whether high blood pressure (BP) is associated with insulin resistance (IR) and b-cell dysfunction.21501840
Cell secretion, Fibrosis AssessmentDeregulated Nutrient SensingIdentification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients.21502328
Hyperglycemia, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingFifteen percent of CF patients had glucose intolerance and 6% had diabetes without fasting hyperglycemia and 3% had diabetes with fasting hyperglycemia.21502328
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPulmonary function impairment has a connection with abdominal obesity, type 2 diabetes, and insulin resistance.21502707
ObesityDeregulated Nutrient SensingThe degrees of obesity and insulin resistance were both negatively associated with esterification-related parameters and positively with FAO (P < 0.05).21505146
Diabetic NephropathyDeregulated Nutrient SensingInsulin resistance at different stages of diabetic kidney disease in India.21510112
Chronic Kidney Diseases, Kidney DiseasesDeregulated Nutrient SensingMany studies showed that Insulin resistance (IR) is present in chronic renal failure and evidences suggest that IR can also occur in early stages of renal disease.21510112
Diabetic NephropathyDeregulated Nutrient SensingThere is paucity of data from India, hence this study was planned to assess the degree of Insulin resistance at different stages of diabetic nephropathy.21510112
Dyslipidemias, Cachexia, atheroscleroticDeregulated Nutrient SensingWe tested a hypothesis that dyslipidemia increases the risk of incident atherosclerotic CVD and that protein energy wasting (PEW) increases the risk of fatality after CVD events in hemodialysis patients.21511840
Cessation of life, Dyslipidemias, atheroscleroticDeregulated Nutrient SensingIn this hemodialysis cohort, dyslipidemia was associated with increased risk of incident atherosclerotic CVD, and protein energy wasting/inflammation with increased risk of death after CVD events.21511840
Atrial Fibrillation by ECG Finding, Hypertrophic CardiomyopathyDeregulated Nutrient SensingRisk for atrial fibrillation in patients with hypertrophic cardiomyopathy: association with insulin resistance.21515029
Atrial Fibrillation, Health maintenance, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingWe also evaluated the relation between the development of atrial fibrillation (AF) and insulin resistance (IR) in patients with HCM.21515029
Inflammation, Dyslipidemias, atherosclerotic, ObesityDeregulated Nutrient SensingObesity related dyslipidemia, chronic inflammation and oxidative stress were associated with atherosclerotic sequels.21515245
Diabetes MellitusDeregulated Nutrient SensingThe Akt2 gene is not a major cause of diabetes in a non-obese Chinese Han population characterized by insulin resistance.21518566
DyslipidemiasDeregulated Nutrient SensingResults indicate a high prevalence of dyslipidemia, and an increase of excess weight and sedentary activity between both surveys.21519701
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingIn comparison to the control group, RA patients showed a higher prevalence of associated dyslipidaemia (95.7% versus 65.9% of cases, p < 0.001).21523363
Refractory anemias, CD55 gene, DyslipidemiasDeregulated Nutrient SensingCorticoid dose was not associated to dyslipidaemia, but in multiple regression models, corticoid dose may be negatively related to some atherogenic markers, in particular non-HDL-c. Tunisian patients with markedly active RA experience substantially reduced serum HDL-c and increased TC, LDL-c and Lp (a) concentrations as well as increased TC/HDL-c, LDL-c/HDL-c and non-HDL-c/HDL-c ratios.21523363
Chronic disease, Diabetes MellitusDeregulated Nutrient SensingDiabetes is a chronic disease that is characterized by an increased blood glucose level due to insulin resistance.21523426
Dyslipidemias, ObesityDeregulated Nutrient SensingThe authors'; findings indicate another reason to fight the increasing prevalence of obesity and dyslipidemia.21523720
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTraditional cardiovascular risk factors were highly prevalent (hypertension 45.2%, diabetes 25.8%, dyslipidemia 38.7%, nicotine use 45.2%).21523886
Angiomyolipoma of kidneyDeregulated Nutrient SensingThis study investigated the efficacy and safety of the mTORC1 inhibitor sirolimus for treatment of renal angiomyolipomas in patients with these disorders.21525172
DyslipidemiasDeregulated Nutrient SensingPatients with T2DM and dyslipidemia under metformin monotherapy with hemoglobin A1c value between 6.5% and 9.0% were eligible for trial participation.21527115
Inflammation, Sarcopenia, Malnutrition, Chronic diseaseDeregulated Nutrient SensingThe causes of sarcopenia are multifactorial and can include disuse, altered endocrine function, chronic diseases, inflammation, insulin resistance, and nutritional deficiencies.21527165
FAM126A geneDeregulated Nutrient SensingIn this study, we found that SIRT1 is essential for the tumorigenesis of HCC.21527554
FAM126A geneDeregulated Nutrient SensingWe showed that although SIRT1 was expressed at very low levels in normal livers, it was overexpressed in HCC cell lines and in a subset of HCC.21527554
Neoplasms, FAM126A geneDeregulated Nutrient SensingTissue microarray analysis of HCC and adjacent nontumoral liver tissues revealed a positive correlation between the expression levels of SIRT1 and advancement in tumor grades.21527554
FAM126A geneDeregulated Nutrient SensingDownregulation of SIRT1 consistently suppressed the proliferation of HCC cells via the induction of cellular senescence or apoptosis.21527554
FAM126A geneDeregulated Nutrient SensingThere was also a positive correlation between the level of induction of SIRT1 and TERT [corrected] in human HCC.21527554
FAM126A geneDeregulated Nutrient SensingFinally, SIRT1-silencing sensitized HCC cells to doxorubicin treatment.21527554
FAM126A geneDeregulated Nutrient SensingTogether, our findings reveal a novel function for SIRT1 in telomere maintenance of HCC, and they rationalize the clinical exploration of SIRT1 inhibitors for HCC therapy.21527554
Liver carcinoma, NeoplasmsDeregulated Nutrient SensingSirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.21527554
Spinal Cord Injuries, Stanford Cancer Institute, DyslipidemiasDeregulated Nutrient SensingDescribe the management of dyslipidemia and adherence to the National Cholesterol Educational Program (NCEP) guidelines in men with Spinal Cord Injury (SCI).21528624
DyslipidemiasDeregulated Nutrient SensingDyslipidemia was well controlled in low risk individuals, but control was less common in higher risk individuals.21528624
Dyslipidemias, Stanford Cancer Institute, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is common in men age 45-70 with chronic SCI and no evidence of clinical cardiovascular disease.21528624
Hypertriglyceridemia, Hypertension, CTCAEDeregulated Nutrient SensingThe presence of family history, puberty, insulin resistance and hypertriglyceridemia constitute important risk factors for developing hypertension.21528810
ObesityDeregulated Nutrient SensingThe relationship between serum phosphate levels with childhood obesity and insulin resistance.21528821
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIncidence of diabetes mellitus, hypertension, and dyslipidemia increased as BMI increased (p <0.05).21529741
Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity is a major risk factor for development of insulin resistance, a proximal cause of type 2 diabetes and is also associated with an increased relative risk of Alzheimer's disease.21538175
Weight Gain, "Alzheimers Disease", Glucose Intolerance (disease)Deregulated Nutrient SensingOur results indicate that Alzheimer's disease increases susceptibility to body weight gain induced by HFD, and to the associated glucose intolerance and insulin resistance.21538175
Alzheimers Disease", Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingSusceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.21538175
Glucose Intolerance (disease)Deregulated Nutrient SensingThe mechanism(s) behind this glucose intolerance in PSEN1 and APP/PSEN1 mice appeared to involve increased levels of brain retinol-binding protein 4 and basal phosphorylation of S6 ribosomal protein, and decreased insulin-stimulated phosphorylation of Akt/protein kinase B and extracellular signal-regulated kinase 1/2 in the brain.21538175
Inflammation, Vascular Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance, inflammation, and vascular disease in nondiabetic predialysis chronic kidney disease patients.21538390
Cardiovascular morbidity, Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingChronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality, which is not fully explained by traditional risk factors; hence, the interest in nontraditional risk factors such as inflammation and insulin resistance (IR).21538390
Steatohepatitis, ObesityDeregulated Nutrient SensingSirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.21540183
Obesity, Diabetes MellitusDeregulated Nutrient SensingSIRT1 is involved in the pathogenesis of obesity, diabetes, and aging.21540183
ObesityDeregulated Nutrient SensingIn vivo, SIRT1 undergoes an extensive degradation in hepatocytes in obesity as a consequence of persistent activation of JNK1.21540183
SteatohepatitisDeregulated Nutrient SensingThe degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis.21540183
Steatohepatitis, ObesityDeregulated Nutrient SensingThe JNK1-SIRT1 pathway provides a new molecular mechanism for the pathogenesis of hepatic steatosis in obesity.21540183
Hyperglycemia, Acute heart failure, Diabetes MellitusDeregulated Nutrient SensingAcute hyperglycemia and insulin resistance in acute heart failure syndromes without previously known diabetes.21544537
Acute heart failure, F8 wt AlleleDeregulated Nutrient SensingNo data is so far available on the relation between glucose values and insulin resistance and mortality, both at short- and long-term, in patients with acute heart failure syndromes (AHF).21544537
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingAbout 67% of the patients had dyslipidaemia, 14.3% had type 2 diabetes mellitus and 59.2% had systemic arterial hypertension.21545540
Dyslipidemias, PsoriasisDeregulated Nutrient SensingThe Psoriasis Area and Severiy Index were equal or over 10 in 27 patients, 18 of whom had dyslipidaemia (P = 0.929) and 14 of whom had the MS (P = 0.327).21545540
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAfter adjustment for covariates, the Hp2-2 genotype (vs. Hp1-1; OR 3.841) remained significantly associated with the development of CKD, together with diabetes (OR 3.131), hypertension (OR 1.748) and dyslipidemia (OR 1.646).21546768
Low Back Pain, Osteoporosis, palladium, Parkinson Disease, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Depression, CTCAE, Arthritis, Hypertension, CTCAEDeregulated Nutrient SensingThis study was designed to evaluate the impact of other common self-reported comorbid disorders (hypertension, dyslipidemia, ischemic heart disease, diabetes mellitus, minor stroke, arthritis, low back pain or osteoporosis and depression) on health-related Quality of Life (HRQoL) of Parkinson's disease (PD) patients and to explore the association of their HRQoL with various sociodemographic and clinical factors.21547746
Dyslipidemias, Pulmonary EmbolismDeregulated Nutrient SensingDyslipidemia as a long-term marker for survival in pulmonary embolism.21549676
Presenile dementia, Dyslipidemias, NeoplasmsDeregulated Nutrient SensingFactors independently associated with reduced survival rate were: creatinine levels > 2 (OR, 8.8; 95% CI, 1.1 - 70.87), previous neoplasm (OR, 8.8; 95% CI, 3.69 - 20.98), dementia (OR, 6.85; 95% CI, 2.1 - 22.33) and dyslipidemia (OR, 5.07; 95% CI, 1.92 - 13.44).21549676
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingInsulin resistance is getting important in the course of type 1 diabetes mellitus.21553302
diabeticDeregulated Nutrient SensingThis measurement may point to the presence of insulin resistance in type 1 diabetic patients.21553302
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.21556362
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevious studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes.21556362
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older.21556362
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.21556362
diabeticDeregulated Nutrient SensingAAS have the potential to induce or exacerbate diabetic conditions due to decreased glucose tolerance and increased insulin resistance.21558143
Hyperlipidemia, Non-alcoholic Fatty Liver Disease, Overweight, Hypertension, CTCAEDeregulated Nutrient SensingHyperlipidemia, overweight, insulin resistance and hypertension are associated with non-alcoholic fatty liver disease.21561285
InflammationDeregulated Nutrient SensingBiomarkers of inflammation, the level of oxidative stress, insulin resistance, and serum vitamin D levels were measured.21562784
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingIn patients with NAFLD and atherogenic dyslipidemia appointment of combination therapy of statins and probiotics are more effective in lowering cholesterol and products of metabolism of intestinal microflora compared with monotherapy.21563361
DyslipidemiasDeregulated Nutrient SensingComparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study.21564441
Dyslipidemias, FBN2 wt Allele, Dental Plaque, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, atheroscleroticDeregulated Nutrient SensingA specific longitudinal gradient of strain (reduced strain, i.e., lower radial strain at the plaque level than at the adjacent segment) has been shown in atherosclerotic plaques on the common carotid artery (CCA) in patients with hypertension, dyslipidemia, or type 2 diabetes mellitus.21565733
Hypoadiponectinemia, DyslipidemiasDeregulated Nutrient SensingHIV patients on antiretroviral therapy (ART) have a unique dyslipidemia [elevated triglycerides and non-high-density lipoprotein-cholesterol (HDL-C), low HDL-C] with insulin resistance (characterized by hypoadiponectinemia).21565796
Hypoadiponectinemia, DyslipidemiasDeregulated Nutrient SensingCombination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive," a randomized, controlled trial.21565796
Hypoadiponectinemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingA combination of fenofibrate and niacin with low-saturated-fat D/E is effective and safe in increasing HDL-C, decreasing non-HDL-C and hypertriglyceridemia, and ameliorating hypoadiponectinemia in patients with HIV/ART-associated dyslipidemia.21565796
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingA post hoc analysis of data collected by a prospective cluster randomized trial with 7041 patients diagnosed with clinical atherosclerosis requiring secondary prevention of dyslipidemia and 127 primary care physicians over an 18-month period.21566005
Liver carcinomaDeregulated Nutrient SensingExpression and role of SIRT1 in hepatocellular carcinoma.21567102
Primary malignant neoplasmDeregulated Nutrient SensingSilent mating type information regulation 2 homolog 1 (SIRT1) is a multifaceted, nicotinamide adenine dinucleotide-dependent protein deacetylase with involvement in a wide variety of cellular processes ranging from cancer to aging.21567102
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingExpression of SIRT1 was evaluated in 90 cases of hepatocellular carcinoma (HCC) and five HCC cell lines.21567102
FAM126A geneDeregulated Nutrient SensingExpression of SIRT1 was significantly elevated in the HCC tissues when compared to that of non-tumor tissues (p<0.001).21567102
Virus DiseasesDeregulated Nutrient SensingExpression of SIRT1 showed significant correlation with gender (p=0.023), serum AFP levels (p=0.030), viral infection (p=0.005) and p53 expression (p<0.021).21567102
FAM126A geneDeregulated Nutrient SensingSIRT1 silencing was found to induce cell growth arrest in HCC cells.21567102
Primary malignant neoplasm, FAM126A geneDeregulated Nutrient SensingThese results suggest an association of SIRT1 expression with HCC development and that SIRT1 plays a role in cancer cell growth.21567102
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is mainly caused by insulin resistance.21569294
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingPatients with undiagnosed diabetes had a lower prevalence of hypertension, dyslipidaemia, peripheral vascular disease and previous myocardial infarction than those with clinical diabetes and similar to that of those without diabetes.21569580
Cerebrovascular Disorders, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe predictors for a pathological ABI included male gender, smoking, dyslipidemia, family history of premature cardiovascular disease, sedentary lifestyle, diabetic-related complications, heart and cerebrovascular diseases.21570647
DyslipidemiasDeregulated Nutrient SensingPersistent dyslipidemia is a reality in statin-treated patients and may contribute to their residual cardiovascular risk.21574067
DyslipidemiasDeregulated Nutrient SensingAdiponectin may also be associated with insulin resistance, dyslipidemia, and the inflammatory response in these patients.21574896
Diabetes MellitusDeregulated Nutrient SensingC57BL/6J and 129S6/Sv (B6 and 129) mice differ dramatically in their susceptibility to developing diabetes in response to diet- or genetically induced insulin resistance.21576825
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingHypertension occurred in 75.8% of the patients, dyslipidemia in 52.6%, and obesity in 57.1%.21584418
Obesity, Abdominal, Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingRegarding RF, 76.3% presented dyslipidemia, 52.7% abdominal obesity, 48.1% arterial hypertension, and 42.3% whole body obesity.21584430
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is often associated with hypertension, and many clinical trials have shown that lipid-lowering therapy and strict blood pressure (BP) control are important for preventing cardiovascular disease (CVD).21593784
DyslipidemiasDeregulated Nutrient SensingIn patients with mild-to-moderate dyslipidaemia, elevated BP increases the risk for CVA/TIA and other CVD, and rigorous BP control was important for preventing CVD, in particular CVA/TIA.21593784
DyslipidemiasDeregulated Nutrient SensingA significant interaction among BMI, dyslipidemia, and APOE genotype was observed that could identify elderly patients with different risks of mortality.21595502
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingHypertension, dyslipidemia, and central obesity affected 84.6%, 76.8%, and 53.5% of patients, respectively.21599865
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOverall, more than half (58.1%) had any of the considered comorbidities; hypertension (36.1%), dyslipidemia (27.0%) and diabetes (15.1%) being the most common.21599917
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingCAD prevalence increases with age, dyslipidemia, and hypertension, but we did not detect an independent prognostic effect of CAD on mortality.21600533
Diabetes Mellitus, Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance and hypertension in patients with type 1 diabetes.21601483
Kidney Failure, Chronic, Ventricular hypertrophyDeregulated Nutrient SensingInsulin resistance and left ventricular hypertrophy in end-stage renal disease: association between the ENPP1 gene and left ventricular concentric remodelling.21602183
Kidney Failure, Chronic, Left Ventricular Hypertrophy, Ventricular hypertrophyDeregulated Nutrient SensingLeft ventricular hypertrophy (LVH) and insulin resistance (IR) are frequent complications of end-stage renal disease (ESRD).21602183
ObesityDeregulated Nutrient SensingOmentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity.21602837
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingOverweight was associated with socioeconomic, demographic, and morbidity variables such as hypertension and dyslipidemia.21603763
Glucose Intolerance (disease), AtherosclerosisDeregulated Nutrient SensingThe effect of non-diabetic glucose intolerance on early atherosclerosis is not as straightforward, and the data regarding sex-related differences in this matter are limited.21604003
Carotid Atherosclerosis, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiabetes and non-diabetic glucose intolerance are associated with increased early carotid atherosclerosis compared with normal glucose tolerance in both sexes.21604003
Glucose Intolerance (disease)Deregulated Nutrient SensingOur results suggest that women with glucose intolerance may be in greater risk than men.21604003
Lichen Planus, DyslipidemiasDeregulated Nutrient SensingRecently a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients.21605731
Lichen Planus, Inflammation, DyslipidemiasDeregulated Nutrient SensingChronic inflammation in patients with lichen planus may explain the association with dyslipidemia.21605731
Fatty Liver, Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingConsumption of sugar-sweetened beverages has been shown to be associated with dyslipidemia, insulin resistance, fatty liver, diabetes, and cardiovascular disease.21613559
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHigh surgical risk (P<0.0001), diabetes (P=0.004), dyslipidemia (P=0.006) and elevated levels of NT-proBNP (P<0.0001) were significantly correlated with events.21617607
OverweightDeregulated Nutrient SensingLower extremity fat mass is associated with insulin resistance in overweight and obese individuals: the CARDIA study.21617639
Dyslipidemias, physiopathologicalDeregulated Nutrient SensingOur objectives were to elucidate whether (1) the cerebrovascular eNOS-H2O2 pathway was sensitive to oxidative stress associated with aging and dyslipidemia and (2) TXA2 contributed to cerebral eNOS dysfunction.21617900
DyslipidemiasDeregulated Nutrient SensingThromboxane synthase inhibition by furegrelate increased dilations at 12 months in WT and at 3 and 12 months in ATX mice, suggesting an anti-dilatory role of TXA2 with age hastened by dyslipidemia.21617900
Dyslipidemias, PrecociousDeregulated Nutrient SensingIn conclusion, the age-dependent cerebral endothelial dysfunction is precocious in dyslipidemia and involves TXA2 production that limits eNOS activity.21617900
HD Term Type, DyslipidemiasDeregulated Nutrient SensingErythrocyte membrane contents of MUFA and oleic acid were found to be associated with VC scores determined using plain radiographs and with dyslipidemia in patients undergoing HD.21620727
Acute Coronary Syndrome, Dyslipidemias, Chronic heart failure, Diabetes MellitusDeregulated Nutrient SensingIM patients were more likely to have acute coronary syndromes, acute rather than exacerbation of chronic heart failure, and diabetes mellitus and dyslipidemia.21627393
Increased insulin level, InflammationDeregulated Nutrient SensingSerum TBil concentrations were inversely associated with hyperinsulinemia, insulin resistance, and systemic inflammation.21631904
Weight decreased, Diabetes MellitusDeregulated Nutrient SensingDespite their beneficial effects on weight loss and blood lipids, high-protein (HP) diets have been shown to increase insulin resistance and diabetes risk, whereas high-cereal-fiber (HCF) diets have shown the opposite effects on these outcomes.21633074
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingWe analyzed whether common variants in the gene encoding CB1, CNR1, are associated with insulin resistance, risk of type 2 diabetes (T2D) or coronary heart disease (CHD).21633404
Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAlthough supported by initial results, we found no reproducible statistical association of common variation at CNR1 with insulin resistance, T2D, or CHD.21633404
Inflammation, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and type 2 Diabetes have been associated to a low grade of inflammation and their prevalence increase with ageing.21635187
Diabetes MellitusDeregulated Nutrient SensingHigh serum fasting peptide YY (3-36) is associated with obesity-associated insulin resistance and type 2 diabetes.21635925
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingAlthough high PYY(3-36) is strongly linked to obesity and associated insulin resistance, the relation between PYY(3-36) and type 2 diabetes is independent of body fatness.21635925
AneuploidyDeregulated Nutrient SensingOur data highlight new role for SIRT1 in maintenance of chromosome stability in mitosis and suggests how diminished SIRT1 activity during aging and tumorigenesis may lead to aneuploidy and genomic instability.21636977
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient Sensing[Therapeutic approach to dyslipidemia and goal achievement in a Spanish population with type 2 diabetes without cardiovascular disease].21641286
Diabetes Mellitus, Non-Insulin-Dependent, Chronic diseaseDeregulated Nutrient SensingIndirectly, results also implicate muscle as a potential mediator between poor fetal growth and adult chronic disease, given muscle's direct role in determining insulin resistance, type II diabetes, physical activity, and so forth.21641734
Malnutrition, DyslipidemiasDeregulated Nutrient SensingDyslipidemia can be found in patients with malnutrition, a severe condition that needs prompt nutrition intervention.21642469
Malnutrition, DyslipidemiasDeregulated Nutrient SensingThis report describes a case of malnutrition causing severe dyslipidemia in a newborn.21642469
Arterial StiffnessDeregulated Nutrient SensingAssociation of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients.21643643
Kidney Failure, Chronic, Cardiovascular morbidityDeregulated Nutrient SensingInsulin resistance is a risk factor for cardiovascular morbidity and mortality in the general and end-stage renal disease populations.21643643
Arterial Stiffness, palladiumDeregulated Nutrient SensingIn this study, we investigated the association between insulin resistance and arterial stiffness in nondiabetic peritoneal dialysis (PD) patients.21643643
Arterial Stiffness, palladiumDeregulated Nutrient SensingInsulin resistance is an independent risk factor for arterial stiffness in PD patients older than 50 years.21643643
Diabetes MellitusDeregulated Nutrient Sensing[Association of the genetic variations of bone morphogenetic protein 7 gene with diabetes and insulin resistance in Xinjiang Uygur population].21644225
Diabetes MellitusDeregulated Nutrient SensingThe present study suggests that the rs6025422 polymorphism in (BMP7) gene may be associated with diabetes mellitus and insulin resistance in Uygur men.21644225
Coronary Artery DiseaseDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile and insulin resistance, which can contribute to the development of coronary artery disease (CAD).21645024
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingDemographics, clinical symptoms, cardiovascular status and risk factors--central obesity, hypertension, dyslipidaemia, smoking.21650069
Proteinuria, Diabetes MellitusDeregulated Nutrient SensingPatients with diabetes, BMI >=30 kg/m(2), and who had the blood collection during the winter or spring had lower levels of 25(OH)D. Serum 25(OH)D correlated inversely with parathyroid hormone, proteinuria, insulin resistance, leptin, and subcutaneous abdominal fat.21652219
Tumor necrosisDeregulated Nutrient SensingBy ingenuity pathway analysis, the tumour necrosis factor receptor 1 (TNFR1) signaling pathway was most affected by metformin: TGFB and MEKK were upregulated and cdc42 downregulated; mTOR and AMPK pathways were also affected.21655990
FailureDeregulated Nutrient SensingThe hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake.21656330
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe drug treatments for hypertension, dyslipidemia, and diabetes increased in a similar pattern.21659455
HypertriglyceridemiaDeregulated Nutrient SensingCriteria-wise insulin resistance, hypertriglyceridemia and low high density lipoprotein also were found at significantly higher rate among obese children.21660399
Cardiovascular systemDeregulated Nutrient SensingRecent publications point towards psoriasis-induced insulin resistance as an important pathomechanism driving cardiovascular comorbidity in these patients.21660442
InflammationDeregulated Nutrient SensingSHBG performed well as a sensitive biomarker for insulin resistance and systemic inflammation in these patients.21660442
Metabolic Diseases, DyslipidemiasDeregulated Nutrient SensingThe main presentation of metabolic disease in Thai patients was dyslipidemia.21666699
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThe dyslipidemia associated with excess weight is a risk profile global call for cardiovascular disease (CVD).21666967
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe low HDL-c was the most prevalent dyslipidemia in all adolescents and hypertriglyceridemia was most prevalent in overweight adolescents.21666967
Presenile dementia, DyslipidemiasDeregulated Nutrient SensingApart from dyslipidemia, there were no associations between dementia and the other vascular risk factors.21668914
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of angiotensin I converting enzyme, angiotensin II type 1 receptor and angiotensin I converting enzyme 2 gene polymorphisms with the dyslipidemia in type 2 diabetic patients of Chinese Han origin.21670585
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe above 3 polymorphisms were genotyped in a total of 282 patients with T2D and dyslipidemia (Group A), 182 patients with T2D but without dyslipidemia (Group B), and 324 healthy controls.21670585
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFurthermore, the ID genotype had a decreased risk of developing T2D without dyslipidemia as compared with controls (OR=0.52, 95% CI=0.32-0.82; p=0.0060).21670585
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe distributions of the AT1R (rs5186) and ACE2 (rs2285666) genotypes and alleles did not differ between T2D patients with or without dyslipidemia and the controls.21670585
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study demonstrates that the ACE (I/D) polymorphism is associated with T2D, regardless of the absence or presence of dyslipidemia.21670585
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of SUMO4 Met55Val variation with increased insulin resistance in newly diagnosed type 2 diabetes in a Chinese population.21671169
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo further examine the related mechanisms, this study was designed to evaluate the association of SUMO4 Met55Val polymorphism with insulin resistance and b cell function in newly diagnosed type 2 diabetic patients in a Chinese population.21671169
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt was concluded that SUMO4 Met55Val variant was associated with increased insulin resistance in Chinese patients with newly diagnosed type 2 diabetes.21671169
HypophosphatemiaDeregulated Nutrient SensingRapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expression.21672148
Thrombus, DyslipidemiasDeregulated Nutrient SensingThrombotic risk factors were found in 43 patients; the most frequent was dyslipidemia (n = 22) followed by oral contraceptive use (n = 18).21672438
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia (P = .012), diabetes (P = .054), and comorbid dyslipidemia and diabetes (P = .006) were more common in the unexplained group.21672496
Cessation of life, Dyslipidemias, Psychiatric, Diabetes MellitusDeregulated Nutrient SensingThe role of diabetes and dyslipidemia as risk factors for sudden death in psychiatric patients requires careful longitudinal studies.21672496
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingPotential benefit of statin therapy for dyslipidemia with chronic kidney disease: Fluvastatin Renal Evaluation Trial (FRET).21673461
Cardiovascular morbidity, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is a common complication of chronic kidney disease (CKD) and contributes to cardiovascular morbidity and mortality of CKD patients.21673461
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypoglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdditive effects of glycaemia and dyslipidaemia on risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish National Diabetes Register.21674176
physiopathological, diabeticDeregulated Nutrient SensingET-1 not only induces vascular dysfunction but also acutely impairs FGU in individuals with insulin resistance and in skeletal muscle cells from type 2 diabetic subjects.21677282
Hypertension, CTCAEDeregulated Nutrient SensingThe associations between G972R polymorphism of the IRS-1 gene, insulin resistance, salt sensitivity and non-dipper hypertension.21677657
Hypertension, CTCAEDeregulated Nutrient SensingOn a high-salt diet, patients with the G972R polymorphism had an increased risk for insulin resistance (odds ratio (OR)=11.42, 95% confidence interval (CI) 7.68-28.44), salt sensitivity (OR=5.38, 95% CI 1.14-25.34) and non-dipper hypertension (OR=3.6, 95% CI 1.07-12.09).21677657
Hypertension, CTCAEDeregulated Nutrient SensingIn conclusion, the results of our study suggest that the G972R polymorphism of the IRS-1 gene is associated with insulin resistance, salt sensitivity and non-dipper hypertension.21677657
Pancreatic carcinomaDeregulated Nutrient SensingSIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells.21677689
Pancreatic carcinoma, NeoplasmsDeregulated Nutrient SensingWe investigated the expression of SIRT1 in pancreatic cancer and the effect of SIRT1-targeted RNA interference (RNAi) on cell proliferation and tumor formation in a pancreatic cancer cell line, PANC1.21677689
Pancreatic carcinomaDeregulated Nutrient SensingThe expression of SIRT1 was investigated in 49 specimens of pancreatic cancer and adjacent normal pancreatic tissues.21677689
Neoplasm Metastasis, Neoplasms, Secondary malignant neoplasm of liver, TNM Staging System, Pancreatic carcinomaDeregulated Nutrient SensingSIRT1 was overexpressed in pancreatic cancer tissues at both the mRNA and protein levels, with increased SIRT1 positivity associated with tumors from patients over 60 years old, tumors larger than 4 cm, higher TNM (extent of tumor (T), the extent of spread to lymph nodes (N), and presence of distant metastasis (M)) stage or the presence of lymph node or hepatic metastases.21677689
NeoplasmsDeregulated Nutrient SensingAdditionally, PANC-1-SIRT1-RNAi cells had a significantly reduced capacity to form tumors in vivo compared with untransfected and PANC-1-negative RNAi cells.21677689
Neoplasms, Pancreatic carcinomaDeregulated Nutrient SensingThese results suggest that SIRT1 may promote cell proliferation and tumor formation in pancreatic cancer, and downregulation of SIRT1 using shRNA could provide a novel therapeutic treatment.21677689
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe levels of SHBG were associated negatively with the risk of T2D, obesity and insulin resistance in both men and women.21679181
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow levels of testosterone and SHBG increase the risk of T2D in men, and high levels of testosterone increase the risk of insulin resistance in women.21679181
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe association between TT levels and the risk of T2D is not completely independent of other variables, such as exposure time, adiposity, insulin resistance or SHBG levels.21679181
Hypertension, CTCAE, Scotoma, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingForty-three per cent presented with visual field defects, 49% had hypertension, 25% diabetes mellitus and 35% dyslipidaemia.21679284
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThere were significant associations between the following risk factors: age, obesity, smoking, hypertension, dyslipidemia, and increased severity of ED (P<0.05 for each).21679302
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPersistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study.21679231
Hyperlipidemia, DyslipidemiasDeregulated Nutrient Sensing[Correlation study on different dyslipidemia classification and glucose metabolism in patients with hyperlipidemia].21681276
Hypertriglyceridemia, Adenoma of large intestine, DyslipidemiasDeregulated Nutrient SensingThe findings of this study suggest that dyslipidemia may affect the incidence of colorectal adenoma, particularly hypertriglyceridemia and low HDL-C levels.21681277
Cerebrovascular accidentDeregulated Nutrient SensingStroke is associated with markers of insulin resistance, low serum levels of HDL, and high total cholesterol/HDL ratio in this African population.21683619
Diabetes MellitusDeregulated Nutrient SensingThere is an increasing body of literature showing associations of organochlorine exposure with risk of diabetes and insulin resistance.21684538
Maturity Onset Diabetes of the Young Pathway, Diabetes Mellitus, Insulin Resistance, Overweight, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEven though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described b-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes.21688019
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity together with dyslipidemia, smoking, diabetes and high blood pressure intensifies oxidative stress.21688559
Dyslipidemias, ObesityDeregulated Nutrient SensingReduced sleep duration was associated with obesity and atherogenic dyslipidemia in young school children in Hong Kong.21689984
Coronary Artery DiseaseDeregulated Nutrient SensingMany patients with coronary artery disease have insulin resistance and altered energy metabolism, which can exacerbate around the time of coronary revascularization.21693564
Psoriasis, Demographics Domain, Refractory anemias, Diabetes Mellitus, Rheumatoid ArthritisDeregulated Nutrient SensingRheumatoid arthritis (RA) and psoriasis have been linked with insulin resistance and diabetes mellitus (DM).21693740
Obesity, Fatty Liver DiseaseDeregulated Nutrient SensingAlcohol consumption was inversely associated with insulin resistance, independent of central obesity, metabolic profiles, and fatty liver diseases.21694610
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCorrelation of insulin resistance, beta cell function and insulin sensitivity with serum sFas and sFasL in newly diagnosed type 2 diabetes.21695404
Structure of beta Cell of isletDeregulated Nutrient SensingOur findings suggest that the pancreatic beta cell dysfunction along with increased insulin resistance appears to be associated with apoptotic markers.21695404
Inflammation, DyslipidemiasDeregulated Nutrient SensingBrain volume reductions have also been associated with chronic low-grade inflammation and dyslipidaemia.21695767
Inflammation, DyslipidemiasDeregulated Nutrient SensingThis study investigated the relationships among T2DM, gender, inflammation, dyslipidaemia, and hippocampal volumes.21695767
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia (hypercholesterolemia and/or hypertriglyceridemia) was defined according to the American Academy of Pediatrics AAP) guidelines.21696080
Dyslipidemias, OverweightDeregulated Nutrient SensingOdds ratio ofhaving dyslipidemia in overweight and/or obese children compared to non-obese children was 4.0 (95% CI 2.0-8.0).21696080
Diabetes MellitusDeregulated Nutrient SensingOur objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey.21697301
Overweight, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.21697301
Inflammation, Kidney Diseases, Retinal Diseases, NeuropathyDeregulated Nutrient SensingPAD; SMI; ED; 24-hour blood pressure Holter; lipid profile; insulin resistance; testosterone; chronic inflammation; nephropathy; retinopathy; neuropathy.21699670
Cataract, Abnormally opaque structure (morphologic abnormality)Deregulated Nutrient SensingTo evaluate the correlation between the severity of lens opacity, patient age, and the level of silent information regulator T1 (SirT1) expression in the lens epithelium of age-related cataracts.21700104
Abnormally opaque structure (morphologic abnormality)Deregulated Nutrient SensingThe expression of SirT1 in lens opacity was significantly less in patients 51 years and older than in those younger than 51 years.21700104
CataractDeregulated Nutrient SensingA significant correlation was also found between a higher N, C, and P cataract score and lower expression of SirT1 in patients with age-related cataract (P < .001).21700104
CataractDeregulated Nutrient SensingThe decreased expression of SirT1 in the lens epithelium was associated with higher cataract scores and patient age.21700104
CataractDeregulated Nutrient SensingThe results suggest that a local SirT1 decrease in cataractous lens could be a risk factor for the initiation of age-related cataract formation.21700104
Arterial Stiffness, DyslipidemiasDeregulated Nutrient SensingEPA may reduce oxidative stress and inhibit the progression of arterial stiffness more efficiently than statin-only therapy in patients with dyslipidemia and CAD.21701083
PliabilityDeregulated Nutrient SensingTranscriptional metabolic inflexibility in skeletal muscle among individuals with increasing insulin resistance.21701566
DyslipidemiasDeregulated Nutrient SensingIt was concluded that dyslipidemia is common in all diabetics.21702294
Demographics Domain, Cerebral Infarction, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Chronic Kidney DiseasesDeregulated Nutrient SensingDiabetes mellitus (DM), dyslipidemia, coronary artery disease (CAD), and chronic kidney disease (CKD), as well as symptomatic cerebral infarction and WML, were more frequent in patients with Fontaine III/IV PAD than without PAD.21703877
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingAmong the clinical variables, dyslipidemia (OR 5.3; CI 95% 1.3-20.9; p=0.016), coronary artery disease (OR 4.2; CI 95% 1.3-13.3; p=0.014) and a positive stress echo response (OR 9.0; CI 95% 1.7-49.1; p=0.011) were independently associated with the occurrence of a cardiovascular event.21705097
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingA positive stress echo response, the presence of coronary artery disease, and dyslipidemia positively predicted the occurrence of cardiovascular events.21705097
BDI - Functional ImpairmentDeregulated Nutrient SensingEndocrine functional impairment with insulin resistance was found in patients after AP.21705952
glycation, Diabetes MellitusDeregulated Nutrient SensingRestriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1.21709297
diabeticDeregulated Nutrient SensingBecause basal OS in type 2 diabetic patients is influenced by the consumption of AGEs, we examined whether AGE consumption also affects IR and whether AGER1 and SIRT1 are involved.21709297
Tumor necrosis, diabeticDeregulated Nutrient SensingInsulin and homeostasis model assessment, leptin, tumor necrosis factor-a and nuclear factor-kB p65 acetylation, serum AGEs, and 8-isoprostanes decreased in AGE-restricted type 2 diabetic patients, whereas PMNC AGER1 and SIRT1 mRNA, and protein levels normalized and adiponectin markedly increased.21709297
Diabetes MellitusDeregulated Nutrient SensingFood-derived pro-oxidant AGEs may contribute to IR in clinical type 2 diabetes and suppress protective mechanisms, AGER1 and SIRT1.21709297
DyslipidemiasDeregulated Nutrient SensingUndernutrition (diminished lean body mass, risk of magnesium and vitamin deficiencies) contrasted with dyslipidemia and increased cardiovascular risk.21709952
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMost reported having arterial hypertension, dyslipidemia, a sedentary lifestyle, and had quit smoking and drinking.21710067
Polycystic Ovary Syndrome, OverweightDeregulated Nutrient SensingThe impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome.21711376
Obesity, AbdominalDeregulated Nutrient SensingVitamin D and parathyroid hormone in insulin resistance of abdominal obesity: cause or effect?21712836
Inflammation, DyslipidemiasDeregulated Nutrient SensingMixed dyslipidemia, oxidative stress and inflammation are related to a high risk for cardiovascular events.21714585
DyslipidemiasDeregulated Nutrient SensingThe greater non-HDL-C- and LDL-C-lowering efficiency of rosuvastatin monotherapy along with its more potent effect on LpPLA2 activity and hsCRP levels indicate that this regimen is a better treatment option for patients with mixed dyslipidemia.21714585
Liver diseases, Neuropathy, Dyslipidemias, Intervertebral Disk Displacement, Heart Diseases, Diabetes Mellitus, Kidney Diseases, Hypertension, CTCAE, Hematological Disease, Arteriopathic diseaseDeregulated Nutrient SensingWe detected subjects suffering from diabetes mellitus, kidney diseases, heart diseases, disk herniation, neuropathy, blood diseases, liver diseases, artery diseases, dyslipidemia, or hypertension.21718253
Diabetes MellitusDeregulated Nutrient SensingAssociation between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus.21718263
Diabetes MellitusDeregulated Nutrient SensingTo examine the associations between insulin resistance and changes in body composition in older men without diabetes mellitus.21718263
Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient Sensingsmoking, overweight or obese, hypertension, dyslipidaemia, or hyperglycaemia) was 31.17, 27.38, 17.76, and 10.19%, respectively.21719451
Cardiovascular DiseasesDeregulated Nutrient SensingRecent studies have demonstrated that mammalian sirtuin 1 (SIRT1), a histone deacetylase, is an exciting target for cardiovascular disease management.21719763
Muscle, Smooth, Vascular, CalcinosisDeregulated Nutrient SensingHere, we investigated the role of SIRT1 in a calcification model of vascular smooth muscle cells (SMCs).21719763
CalcinosisDeregulated Nutrient SensingActivation of SIRT1 by resveratrol significantly reduced the senescence-associated calcification.21719763
CalcinosisDeregulated Nutrient SensingConversely, SIRT1 knockdown by small interfering RNA accelerated the Pi-induced SMC senescence and subsequent calcification.21719763
Arterial calcificationDeregulated Nutrient SensingSIRT1 plays an essential role in preventing hyperphosphatemia-induced arterial calcification via inhibition of osteoblastic transdifferentiation.21719763
Muscle, Smooth, VascularDeregulated Nutrient SensingSirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells.21719763
Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cerebrovascular accidentDeregulated Nutrient SensingStatin users were older age, and had higher frequencies of dyslipidemia, diabetes mellitus, atrial fibrillation, prior stroke history and large HV compared to non-users.21720057
Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingParticularly CHD patients with obesity, diabetes, and dyslipidaemia need better management and control of elevated blood pressure.21720270
Obesity, AtherosclerosisDeregulated Nutrient SensingLiver attenuation, pericardial adipose tissue, obesity, and insulin resistance: the Multi-Ethnic Study of Atherosclerosis (MESA).21720430
Obesity, AbdominalDeregulated Nutrient SensingInsulin resistance is linked to general and abdominal obesity, but its relation to hepatic lipid content and pericardial adipose tissue is less clear.21720430
Vascular Diseases, Cardiomyopathies, Cardiovascular Diseases, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Heart failure, Kidney Diseases, Hypertension, CTCAE, Cardiac ArrhythmiaDeregulated Nutrient SensingRecipients also had an increased cumulative incidence of ischemic heart disease, cardiomyopathy or heart failure, stroke, vascular diseases, and rhythm disorders and an increased incidence of related conditions that predispose toward more serious cardiovascular disease (hypertension, renal disease, dyslipidemia, and diabetes).21727290
Fibrosis Assessment, Fatty degeneration, Hepatitis CDeregulated Nutrient SensingInsulin resistance, steatosis, and fibrosis in Egyptian patients with chronic Hepatitis C virus infection.21727730
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingInsulin resistance has an important role in the pathogenesis of steatosis, which represents a significant determinant of fibrosis together with high serum AST level and older age.21727730
Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidemia was reversed in children who recovered from obesity.21727757
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingNo difference in other risk factors, for example, hypertension, dyslipidemia and smoking, was detected.21728271
Malabsorption Syndrome, Dyslipidemias, Primary Biliary Cholangitis, OsteoporosisDeregulated Nutrient SensingConcomitant to the primary biliary cirrhosis hypothyroidism, osteoporosis, malabsorption and dyslipidemia can occur.21732301
Dyslipidemias, Brain hemorrhage, Diabetes Mellitus, Insulin-Dependent, Rheumatoid Arthritis, Ischemic stroke, Hypertension, CTCAEDeregulated Nutrient SensingHRs were similar for ischemic stroke and brain hemorrhage and were not affected by adjustment for type 1 diabetes, rheumatoid arthritis, use of medication against hypertension, or dyslipidemia.21733721
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow birth weight is associated with type 2 diabetes, which to some extent may be mediated via abdominal adiposity and insulin resistance.21733994
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease markers are associated with insulin resistance in type 1 diabetes.21735081
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) has been associated with the insulin resistance.21735081
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingTo explore the relationship between markers of NAFLD, namely concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALK), g-glutamyltransferase (GGT), ferritin and bilirubin and insulin resistance in type 1 diabetes.21735081
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingCorrelations and multiple logistic regressions analysis were performed to identify the relationships between NAFLD associated markers and eGDR, individual components of insulin resistance and risk of insulin resistance.21735081
Diabetes MellitusDeregulated Nutrient SensingIn a multiple logistic regression model adjusted according to age, sex, duration of diabetes and BMI, increased levels of AST, ALT and ALK resulted in an increased risk for the development of insulin resistance in our subjects (OR = 1.03, 1.02, and 1.01, respectively; all P < 0.05).21735081
Systemic disease, Diabetes MellitusDeregulated Nutrient SensingThese findings indicate that higher levels of ALT, AST and ALK are additional markers of insulin resistance in type 1 diabetes and suggest that those subjects must be considered as potentially affected not only by a hepatic but also by a multisystemic disease through altered insulin sensitivity.21735081
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe control and treatment of dyslipidemia is a major public health challenge, particularly for patients with coronary heart diseases.21735134
Hypertensive (finding)Deregulated Nutrient SensingMoreover, hypertensive patients showed an altered glucose response to stress, as indicated by higher admission glucose values, poorer in-hospital glucose control, and a higher incidence of acute insulin resistance (as indicated by the HOMA index).21735205
Prostate Cancer Outcomes Study, Hyperandrogenism, Polycystic Ovary Syndrome, Cardiovascular DiseasesDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and oligo-/anovulation and is associated with risk factors for cardiovascular disorders, such as insulin resistance and central adiposity.21735693
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia in patients with transient ischemic attack.21737806
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingThere is mounting evidence that atherogenic dyslipidemia (ie, low high-density lipoprotein cholesterol combined with high triglyceride concentrations) is an independent predictor of high cardiovascular risk and possibly of stroke.21737806
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia was defined as high-density lipoprotein cholesterol blood concentration <= 40 mg/dL and triglycerides >= 150 mg/dL.21737806
Dyslipidemias, Tacca leontopetaloides, Cerebral Ischemia, Cerebrovascular accidentDeregulated Nutrient SensingAmong 1471 consecutive patients with transient ischemic attack (TIA) or minor stroke, overall prevalence of atherogenic dyslipidemia was 5.8%, but varied from 4.6% to 11.1%, depending on final diagnosis (possible TIA or TIA with a cerebral ischemic lesion, respectively).21737806
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrevalence of atherogenic dyslipidemia was independently associated with male sex, diabetes, and body mass index, but not with ABCD2 score.21737806
Extracranial, Dyslipidemias, IntracranialDeregulated Nutrient SensingAtherogenic dyslipidemia also strongly associated with symptomatic intracranial stenosis >= 50% (adjusted odds ratio, 2.77; 95% CI, 1.38-5.55), but not with symptomatic extracranial stenosis >= 50% (adjusted odds ratio, 1.20; 95% CI, 0.64-2.26).21737806
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDespite appropriate secondary prevention treatment, 90-day stroke risk was greater in patients with versus without atherogenic dyslipidemia (4.8% versus 1.7%; P=0.04).21737806
Tacca leontopetaloides, Dyslipidemias, Cerebrovascular accident, Structure of intracranial arteryDeregulated Nutrient SensingThe atherogenic dyslipidemia phenotype in patients with TIA may be associated with intracranial artery stenosis and higher risk of early recurrent stroke.21737806
Carotid Intima-Media ThicknessDeregulated Nutrient SensingSubjects with VFA and WC above these cutoff values exhibited increased insulin resistance and increased carotid intima-media thickness.21738344
Rheumatoid ArthritisDeregulated Nutrient SensingResistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis.21739426
Hypertensive (finding)Deregulated Nutrient SensingTo investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients.21742399
HyperthyroidismDeregulated Nutrient SensingTo investigate ghrelin and resistin concentrations in patients with hyperthyroidism before and after restoration to a euthyroid state and to correlate the 2 peptides with anthropometric and insulin resistance parameters.21742599
HyperthyroidismDeregulated Nutrient SensingIn hyperthyroid patients, serum resistin levels and insulin resistance parameters were higher and plasma ghrelin levels were lower than in control participants (P<.001), and all normalized after treatment.21742599
Rheumatoid ArthritisDeregulated Nutrient SensingSIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.21742641
Refractory anemias, Rheumatoid Arthritis, InflammationDeregulated Nutrient SensingTo analyse the expression of SIRT1 in synovial tissues and cells of patients with rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in RA.21742641
Refractory anemias, Tumor necrosisDeregulated Nutrient SensingLevels of SIRT1 expression were analysed in synovial tissues and cells from patients with RA by real-time PCR and western blotting before and after stimulation with toll-like receptor ligands, tumour necrosis factor a (TNFa) and interleukin 1b (IL-1b).21742641
Rheumatoid ArthritisDeregulated Nutrient SensingPeripheral blood monocytes and rheumatoid arthritis synovial fibroblasts (RASFs) were transfected with wild-type or enzymatically inactive SIRT1 expression vectors or with siRNA targeting SIRT1.21742641
Refractory anemiasDeregulated Nutrient SensingCytokine analysis of IL-6, IL-8 and TNFa were performed by ELISA to study the role of SIRT1 on proinflammatory mediators of RA.21742641
Refractory anemias, Degenerative polyarthritisDeregulated Nutrient SensingSIRT1 was found to be constitutively upregulated in synovial tissues and cells from patients with RA compared to osteoarthritis.21742641
DyslipidemiasDeregulated Nutrient SensingWe conclude that dyslipidemia, which increases the risk of CVD by increasing atherogenesis, progresses over time in dialysis patients and becomes worse in CAPD patients.21743212
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn patients with hypertension and obesity showing insulin resistance, treatment with telmisartan significantly improved the hyperinsulin response to glucose loading.21744143
Dyslipidemias, Hypothyroidism, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAEDeregulated Nutrient SensingHypothyroidism is associated with an increase in a number of coronary heart disease (CHD) risk factors including dyslipidemia, hypertension, and elevated levels of homocysteine.21745107
Fibrosis AssessmentDeregulated Nutrient SensingRecently, it has been shown that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC) and liver fibrosis independent of visceral adiposity and insulin resistance.21745307
Impaired cognition, Data types - AddressDeregulated Nutrient SensingWhile insulin resistance is associated with cognitive decline in nondemented aging, higher peripheral insulin may have AD-specific benefits or insulin signaling may be affected by systemic physiologic changes associated with AD.21745566
Heart failure, NeoplasmsDeregulated Nutrient SensingThe tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging.21747166
NeoplasmsDeregulated Nutrient SensingOur findings demonstrate that GAPDH depletion switches human tumor cells to senescent phenotype via AMPK network, in the absence of DNA damage.21749859
Heart Diseases, One Vessel Coronary Disease, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingRisk factors like dyslipidemia, hypertension, previous history of heart disease and triple vessel disease were found more in group A than in group B.21751588
Dyslipidemias, OverweightDeregulated Nutrient SensingThis study evaluated 181 overweight men and women with mixed dyslipidemia.21752880
HepatocarcinogenesisDeregulated Nutrient SensingInsulin resistance plays a role in hepatocarcinogenesis and is decreased by metformin treatment.21752887
Metabolic Diseases, Overnutrition, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity is the most relevant overnutrition disease worldwide and is associated to different metabolic disorders such as insulin resistance and type-2 diabetes.21756320
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular disease prevention for patients with type 2 diabetes is accomplished through hypertension and dyslipidemia management.21775166
OverweightDeregulated Nutrient SensingIn overweight and obese women, insulin resistance is associated with increased MTG content, cardiac remodelling and reduced diastolic function.21775510
ObesityDeregulated Nutrient SensingApelin, which is a newly identified adipokine, is related to obesity and insulin resistance.21775567
ObesityDeregulated Nutrient SensingWe treated the primary adipocytes with high glucose plus insulin because of a close relation between insulin resistance and obesity.21775567
Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response TerminologyDeregulated Nutrient SensingIn addition to traditional risk factors, insulin resistance was associated with an increased risk of DR in Koreans with type 2 diabetes.21775765
Demographics Domain, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of hypertension, impaired glucose tolerance (IGT), diabetes mellitus (DM), dyslipidemia and obesity in our SCS cases were 56%, 50%, 50%, and 19%, respectively, and 75% of cases were associated with two or more cardiovascular risk factors.21775997
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn terms of differential changes in risk factors between the groups, more significant improvements of hypertension, dyslipidemia and IGT/DM were observed in the OP group than in the non-OP group.21775997
TG gene, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIn conclusion, dyslipidemia, using serum TG and TG/HDL-C, in particular, may be useful in identification of women at risk of hypertension, even in those without diabetes and central or general obesity.21776016
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingMediterranean diet improves dyslipidemia and biomarkers in chronic renal failure patients.21776461
Inflammation, Cardiovascular Diseases, Cancer-related fatigue, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia, oxidative stress (OS) and inflammation increase the risk of cardiovascular disease in chronic renal failure (CRF) patients.21776461
Cardiovascular event, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingStatins are widely prescribed drugs in the United States for the management of dyslipidemia, atherosclerosis, and cardiovascular event risk reduction.21777752
Prediabetes syndrome, muscle massDeregulated Nutrient SensingRelative muscle mass is inversely associated with insulin resistance and prediabetes.21778224
Low muscle mass, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance, the basis of type 2 diabetes, is rapidly increasing in prevalence; very low muscle mass is a risk factor for insulin resistance.21778224
Hyperlipidemia, Hypertension, CTCAE, Overweight, Diabetes MellitusDeregulated Nutrient SensingMore than 80% of patients entering cardiac rehabilitation are overweight, with a high prevalence of associated insulin resistance, diabetes, hypertension, hyperlipidemia, and a prothrombotic state.21778256
Endothelial dysfunctionDeregulated Nutrient SensingRepression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.21778425
diabeticDeregulated Nutrient SensingMoreover, compared to streptozotocin-induced wild-type diabetic mice, endothelium-specific SIRT1 transgenic diabetic mice had decreased p66Shc expression at both the mRNA and the protein levels, improved endothelial function, and reduced accumulation of nitrotyrosine and 8-OHdG (markers of oxidative stress).21778425
Endothelial dysfunctionDeregulated Nutrient SensingOur findings indicate that repression of p66Shc expression by SIRT1 contributes to the protection of hyperglycemia-induced endothelial dysfunction.21778425
DyslipidemiasDeregulated Nutrient SensingIn particular, in postmenopausal women the increase in content of total cholesterol, triglycerides, LDL and fibrinogen, the decrease in HDL take place that leads to estrogen-dependent dyslipidemia.21778553
Blood GlucoseDeregulated Nutrient SensingMuscular PDE concentrations associate with age, lower resting mitochondrial activity and insulin resistance, which is determined mainly by body mass and glycemia.21779337
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAfter adjustment for sex, smoking, diabetes, dyslipidemia, BMI, triglycerides and DD, TT and CC genotypes, BMI was independent risk factor of HTA (OR = 3.14; P < 0.001).21779803
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient Sensing(2) The prevalence of with at least one cardiovascular risk factor was 78.00% in this cohort, the top there risk factors were dyslipidemia (61.06%), hypertension (44.59%) and diabetes (13.80%).21781604
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingCKD and hypertension were independent determinants of arteriolar narrowing after adjusting for age, gender, diabetes, dyslipidemia, and smoking history.21784828
DyslipidemiasDeregulated Nutrient SensingFurthermore, gender differences in the association between dyslipidaemia and outcome of DKD are largely unknown.21785041
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHe also had visual field defect, uncontrolled diabetes, and dyslipidemia.21785175
Dental PlaqueDeregulated Nutrient SensingThe total coronary plaque burden (TCPB) was 3.45 +- 1.02 cm(3)/patient and had a positive correlation with waist circumference (r =0.44, p < 0.05) and insulin resistance (r = 0.46, p < 0.05).21785228
NRAS geneDeregulated Nutrient SensingSeveral cancer-associated genes were involved, including gain of BCL2L1, ARTN, AMPK, NRAS, and CCNA1 and loss of IGF2, CDKN1C, PAX6, WT1, TRAF6, MAPK8IP1, and IMP3.21785329
AtherosclerosisDeregulated Nutrient SensingCross-sectional and longitudinal changes of glucose effectiveness in relation to glucose tolerance: the insulin resistance atherosclerosis study.21788626
DyslipidemiasDeregulated Nutrient SensingAltered serum selenium and uric acid levels and dyslipidemia in hemodialysis patients could be associated with enhanced cardiovascular risk.21789541
DyslipidemiasDeregulated Nutrient SensingHPs showed a marked dyslipidemia, with a significant reduction in total cholesterol, low-density lipoprotein, and high-density lipoprotein cholesterol levels and a significant increase in triglyceride levels (p < 0.001).21789541
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingThe marked dyslipidemia and hyperuricemia found in HPs and the negative correlation between the serum Se and uric acid levels in these patients could imply an enhanced cardiovascular risk.21789541
Calcification of coronary artery, AtherosclerosisDeregulated Nutrient SensingThe relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosis.21798541
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingResults indicate that Lingzhi might have mild antidiabetic effects and potentially improve the dyslipidaemia of diabetes, as shown previously in some animal studies.21801467
OverweightDeregulated Nutrient SensingRelationship of insulin resistance to psychobehavioral characteristics of overweight and obese African American children.21801736
Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingThis study performed to determine the effects of folate supplementation on indices of glycemic control, insulin resistance and lipid profile in overweight and obese men with type 2 diabetes under metformin (at least 1500 mg daily) treatment.21802161
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFolic acid supplementation lowered plasma level of homocysteine, improved glycemic control and insulin resistance in patients with type 2 diabetes.21802161
ObesityDeregulated Nutrient SensingThe association with obesity and insulin resistance is well established.21803757
Chronic Periodontitis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis.21804283
Dyslipidemias, Restless Legs SyndromeDeregulated Nutrient SensingThat is, patients with RLS have lower quality of sleep and dyslipidemia compared to persons without RLS.21804343
Weight Gain, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSecond-generation antipsychotics (SGAs) tend to induce weight gain, dyslipidemia and diabetes mellitus.21807061
CX drug brand name, Dyslipidemias, Family historyDeregulated Nutrient SensingThe presence of CAP was higher in patients with FH of premature CAD in LAD and Cx compared to patients without FH of premature CAD (70.8% vs 58.0%, p=0.013 for LAD; 42.3% vs 30.4%, p=0.021 for Cx; 34.5% vs 29.8%, p=0.348 for RCA).In multinominal logistic regression analysis age, male gender, dyslipidemia and FH of premature CAD seemed significant predictors of primarily noncalcified CAP(OR:1.17, 95% CI:1.07-1.15, p<0.001; OR:0.19, 95% CI:0.09-0.38, p<0.001; OR:2.26, 95% CI:1.21-4.24, p=0.01; OR:3.32, 95% CI:1.74-6.34, p<0.001 respectively) after adjustment for other risk factors.21807431
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBaseline clinical characteristics were similar with hypertension in 146 (78%), dyslipidemia in 85 (45.5%) and diabetes in 68 (36.4%).21808863
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo compare the long-term efficacy and safety of pitavastatin with atorvastatin in patients with type 2 diabetes and combined (mixed) dyslipidaemia.21812889
Impaired cognition, Diabetes MellitusDeregulated Nutrient SensingAMPK g2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age.21813245
ObesityDeregulated Nutrient SensingIncreased serum resistin was found in rodent models of obesity and insulin resistance, whereas contradictory results have been obtained in human studies.21813294
Chronic liver disease, Non-alcoholic Fatty Liver Disease, Cardiovascular DiseasesDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is associated with insulin resistance and cardiovascular disease.21816784
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingOur objective was to examine the relationship between NAFLD and IGF-I levels and to test the hypothesis that free fatty acids-induced insulin resistance might impair insulin-induced increase of GH receptor (GHR) expression in human hepatoma cells.21816784
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese data show that IGF-I levels are reduced in subjects with NAFLD and suggest that hepatic insulin resistance may affect IGF-I levels by modulating GH-stimulated synthesis of hepatic IGF-I.21816784
Microalbuminuria, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingThe patients with CKD were older, had had diabetes mellitus longer, and had higher incidence of hypertension, dyslipidemia and microalbuminuria than those without.21817822
Chronic diseaseDeregulated Nutrient SensingThese data suggest that differences in lipid and lipoprotein concentrations, liver function, and insulin resistance may explain why the risks of chronic disease are lower in men who are fat and fit than those who are fat and unfit.21820133
Gout, Dyslipidemias, Prostate carcinoma, Diabetes Mellitus, Breast Carcinoma, Malignant Neoplasms, Hypertension, CTCAEDeregulated Nutrient SensingThe most common cancers were liver, colon, lung, breast, and prostate cancer; and except for breast cancer, their incidences increased independently of hypertension, dyslipidemia, and gout in patients with diabetes.21820134
Chronic diseaseDeregulated Nutrient SensingThese data underscore the need for a better understanding of postprandial fatty acid oxidation and dietary fat delivery in the setting of adipose insulin resistance to determine how postprandial lipemia contributes to chronic disease risk.21820684
Polycystic Ovary Syndrome, Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic DiseasesDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) and type 2 diabetes (T2D) are two common metabolic disorders in reproductive-aged women, and both are associated with insulin resistance.21820924
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingRacial and geographic differences in prevalence, awareness, treatment and control of dyslipidemia: the reasons for geographic and racial differences in stroke (REGARDS) study.21822024
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingRacial and geographic differences in dyslipidemia prevalence, awareness, treatment and control may, in part, account for the observed disparities in stroke mortality.21822024
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingRacial, but not geographic, differences in dyslipidemia management may play a role in the excess stroke burden in the Southeast.21822024
macroangiopathy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy.21822540
macroangiopathy, Diabetes Mellitus, Non-Insulin-Dependent, Yin DeficiencyDeregulated Nutrient SensingTo investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficiency of yin, Qi-Yin deficiency, and Yin-Yang deficiency, according to the TCM syndromes, with a control group of 20 healthy individuals.21822540
Yin DeficiencyDeregulated Nutrient SensingInsulin resistance plays an important role in the occurrence of T2DM macroangiopathy and is closely associated with the Yin-Yang deficiency according to the TCM differentiating types.21822540
Toxic effectDeregulated Nutrient SensingCorticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass.21822910
Heart failureDeregulated Nutrient SensingAMP activated protein kinase-a2 regulates expression of estrogen-related receptor-a, a metabolic transcription factor related to heart failure development.21825219
LipodystrophyDeregulated Nutrient SensingLipodystrophy, insulin resistance, and adiponectin concentration in HIV-infected children and adolescents.21827385
Metabolic Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingAlterations of fat distribution and insulin resistance are associated with increased risk of metabolic derangements and cardiovascular disease.21827385
Lipodystrophy, HypoadiponectinemiaDeregulated Nutrient SensingHIV-infected adult patients on antiretroviral treatment often show lipodystrophy, insulin resistance and hypoadiponectinemia, but data in children are controversial.21827385
Lipohypertrophy, CTCAEDeregulated Nutrient SensingLow adiponectin concentration is associated to central fat and mixed lipohypertrophy, and to signs of insulin resistance in HIV-infected youths.21827385
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia is increasing in many parts of Brazil, but it is yet unclear how much exercise is needed to attain beneficial effects on plasma lipoprotein levels.21830000
Dyslipidemias, Sao PauloDeregulated Nutrient SensingThe study analyzed eight cities of the state of Sao Paulo, the association between the continued practice of physical exercise throughout life and the occurrence of dyslipidemia in adulthood.21830000
DyslipidemiasDeregulated Nutrient SensingWomen (p = 0.001) and obese individuals (p = 0.001) had a higher rate of dyslipidemia.21830000
DyslipidemiasDeregulated Nutrient SensingPhysically active adults in all three stages of life were 65% less likely to report dyslipidemia (OR = 0.35 [0.15 to 0.78]).21830000
DyslipidemiasDeregulated Nutrient SensingThe continued practice of physical exercise throughout life was associated with a lower incidence of dyslipidemia in adults in the State of Sao Paulo.21830000
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe association of bone density and calcified atherosclerosis is stronger in women without dyslipidemia: the multi-ethnic study of atherosclerosis.21834088
SLC25A20 gene, DyslipidemiasDeregulated Nutrient SensingThe inverse association of BMD with CAC is stronger in women without dyslipidemia.21834088
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThese data argue against the hypothesis that dyslipidemia is the key factor responsible for the inverse association of BMD with atherosclerosis.21834088
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingRecipient characteristics associated therewith were higher body mass index (P = .000), smoking habit (P = .003), ischemic cardiopathy (P = .01), and dyslipidemia (P = .05).21839224
Acanthosis NigricansDeregulated Nutrient SensingAcanthosis nigricans is a hyperkeratotic lesion of the epidermis associated with insulin resistance.21839533
Diabetes MellitusDeregulated Nutrient SensingThe Finnish Diabetes Risk Score is associated with insulin resistance but not reduced b-cell function, by classical and model-based estimates.21843304
Nonalcoholic Steatohepatitis, Hepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease associated with insulin resistance and its metabolic consequences.21845516
Gestational Diabetes, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGestational diabetes mellitus (GDM), a state of glucose intolerance associated with pregnancy, is increasing in prevalence.21847538
Inflammation, Infection, Diabetes MellitusDeregulated Nutrient SensingLikewise, chronic inflammation or infections seem to provoke insulin resistance and thereby contribute to the development of diabetes and its complications.21848608
Gastroesophageal reflux diseaseDeregulated Nutrient SensingIncreasing insulin resistance is associated with increased severity and prevalence of gastro-oesophageal reflux disease.21848629
InflammationDeregulated Nutrient SensingSix-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice.21849520
Steatohepatitis, Inflammation, Meibomian gland dysfunctionDeregulated Nutrient SensingIncreased visceral fat, as opposed to subcutaneous/gluteal, most strongly relates to key metabolic dysfunctions including insulin resistance, hepatic steatosis, and inflammation.21852815
Prostate Cancer Outcomes Study, Hyperandrogenism, Polycystic Ovary Syndrome, Cardiovascular DiseasesDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo/anovulation and is associated with risk factors for cardiovascular diseases, such as insulin resistance and central adiposity.21853932
Hypertension, CTCAE, Retinal Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension (p < 0.05), suboptimal glycaemic control (p < 0.05) and long diabetes duration (p < 0.05) were associated with risk of retinopathy whilst lower age of diagnosis and dyslipidaemia were not significant predictive factors.21855159
LipodystrophyDeregulated Nutrient SensingAmong patients receiving HAART, those with lipodystrophy had a greater degree of insulin resistance, higher triglyceride levels, and lower levels of high-density lipoprotein cholesterol.21856599
Arterial Stiffness, DyslipidemiasDeregulated Nutrient SensingLow-dose rosuvastatin would be more effective than fluvastatin in improving arterial stiffness in high-risk Japanese patients with dyslipidemia.21857142
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingTranscriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.21858147
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingNotably, sex-biased genes are enriched at loci associated with polygenic dyslipidemia and coronary artery disease in genome-wide association studies.21858147
diabeticDeregulated Nutrient SensingThe expression of a protein deacetylase that targets Foxo4 for deacetylation, sirtuin (Sirt1), is down regulated in cultured podocytes by AGE-BSA treatment and in glomeruli of diabetic patients.21858169
Diabetes MellitusDeregulated Nutrient SensingTogether, our data provide evidence that alteration of Foxo4 acetylation and down regulation of Sirt1 expression in diabetes promote podocyte apoptosis.21858169
Diabetes MellitusDeregulated Nutrient SensingStrategies to preserve Sirt1 expression or reduce Foxo4 acetylation could be used to prevent podocyte loss in diabetes.21858169
Diabetic Nephropathy, Dyslipidemias, diabeticDeregulated Nutrient SensingPrevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state south-east Nigeria.21860134
Diabetic Nephropathy, DyslipidemiasDeregulated Nutrient SensingDyslipidemia has been identified as a risk factor for the development and progression of diabetic renal disease.21860134
Dyslipidemias, Kidney Diseases, diabeticDeregulated Nutrient SensingThis study was done to determine the prevalence of dyslipidemia among diabetic patients with overt nephropathy.21860134
Diabetic Nephropathy, Dyslipidemias, Kidney Failure, Chronic, diabeticDeregulated Nutrient SensingDiabetic patients with overt diabetic nephropathy have significant dyslipidemia and aggressive lipid lowering in these patients may retard their progression to end-stage renal disease.21860134
deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingContribution of insulin deficiency and insulin resistance to the development of type 2 diabetes: nature of early stage diabetes.21861172
Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingAt the time of diagnosis of type 2 diabetes (T2D), patients already have varying degrees of beta-cell dysfunction and insulin resistance and the defects continue to deteriorate despite treatment.21861172
Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingWe examined insulin secretion impairment and insulin resistance in overweight patients with T2D who had metformin failure, with elevated HbA1c at maximal metformin dose.21861172
Beta-cell dysfunctionDeregulated Nutrient SensingMetformin failure in these patients was associated with beta-cell dysfunction to a greater extent than insulin resistance.21861172
Inflammation, Endothelial dysfunction, diabeticDeregulated Nutrient SensingWe assessed whether cardiovascular risk factors including more novel factors such as markers of insulin resistance, inflammation, activated coagulation and endothelial dysfunction differ more between diabetic and non-diabetic women than between diabetic and non-diabetic men, and the role of insulin resistance.21861177
diabetic, Diabetes MellitusDeregulated Nutrient SensingLevels of waist circumference, BMI, von Willebrand factor (VWF), WBC count, insulin resistance (HOMA-IR), diastolic blood pressure, HDL-cholesterol, tissue plasminogen activator (t-PA) and factor VIII differed more between diabetic and non-diabetic women than between diabetic and non-diabetic men (test for diabetes x sex interaction p < 0.05).21861177
Diabetes MellitusDeregulated Nutrient SensingThe more adverse effect of diabetes on these risk markers in women was associated with, and thereby largely attenuated by, insulin resistance.21861177
Dyslipidemias, PsychiatricDeregulated Nutrient SensingPhysiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients.21861666
Dyslipidemias, Hypertension, CTCAE, AtherosclerosisDeregulated Nutrient SensingCommon atherosclerosis risk factors were dyslipidemia (80.2%), hypertension (71.8%) and smoking (40.7%).21863674
ObesityDeregulated Nutrient SensingOur objective was to determine whether regional fat distribution, independent of obesity, is associated with insulin resistance.21865361
Hyperglycemia, Dyslipidemias, Cerebrovascular accident, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe Western dietary patterns also association with high risk of stroke, which was largely mediated by obesity, hypertension, hyperglycemia, and dyslipidemia.21865562
Hepatitis CDeregulated Nutrient SensingRelation of serum insulin-like growth factor-1 (IGF-1) levels with hepatitis C virus infection and insulin resistance.21867981
Hyperlipidemia, No metabolic abnormalities, Inflammation, ObesityDeregulated Nutrient SensingIn particular, no single agent can correct multiple metabolic abnormalities such as insulin resistance, hyperlipidemia, inflammation, obesity, and fat distribution.21869685
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe rate of resolution of diabetes, hypertension, and dyslipidemias were also similar with no statistical significance.21870050
ObesityDeregulated Nutrient SensingA lower exercise tolerance in elderly people without obesity can be considered not only as a risk factor for insulin resistance, but also as its consequence.21870513
Dyslipidemias, Depression, CTCAE, ObesityDeregulated Nutrient Sensingin these patients there was noticed a higher prevalence of dyslipidemias, obesity and depression in women.21870719
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingInsulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC).21874260
Dyslipidemias, Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingIn conclusion, changes in lipid variables and some hematological parameters may increase plasma viscosity as a step during atherosclerosis pathogenesis in male youth at risk for dyslipidemia and cardiovascular diseases.21874826
DyslipidemiasDeregulated Nutrient SensingWe have shown its efficacy in correction of diabetic dyslipidemia, positive influence on clinical status and long term result of coronary intervention.21878080
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe MIG had twice the prevalence rate of diabetes as the LIG and higher prevalence rates of hypertension, obesity, and dyslipidemia.21880235
Cardiovascular DiseasesDeregulated Nutrient SensingGiven that both insulin sensitivity and insulin resistance were found to be significant determinants of the difference between SBP and SBP2 in a healthy general population, we suggest measuring the SBP2 in individuals with impaired insulin action in order to accurately assess their risk of developing cardiovascular disease.21881525
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAlso, the frequency of diabetes and dyslipidemia, and the plasma high sensitive C-reactive protein levels, were higher in the poor CCC group (P = 0.003, P = 0.018, P<0.001, respectively).21887692
Premature coronary artery atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingThere was a linear increase in the mean values of HOMA IR with increase in number of components of MS [p for trend < 0.001] Among Asian Indians who are known to have high risk of premature coronary artery disease and diabetes, a significant association exists between insulin resistance with cardiovascular risk factors even among NGT subjects.21887902
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAir pollution may promote type 2 diabetes by increasing adipose inflammation and insulin resistance.21888674
Retinal Pigments, Personal Experience InventoryDeregulated Nutrient SensingDelivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium.21890195
Retinal ConeDeregulated Nutrient SensingImportantly, PU-PEI-mediated Oct4/SirT1 gene transfer rescued retinal cell loss and improved electroretinographic responses in light-injured rat retinas.21890195
Nonalcoholic Steatohepatitis, Biliary calculiDeregulated Nutrient SensingAdditionally, insulin resistance - linked to the development of non-alcoholic steatohepatitis - increases the risk of developing gallstones.21893698
ObesityDeregulated Nutrient SensingGhsr ablation improves aging-associated obesity and insulin resistance by reducing adiposity and increasing thermogenesis.21895961
Alzheimers Disease", glucose metabolism, Cognition Disorders, Data types - AddressDeregulated Nutrient SensingGlucose dysmetabolism has been consistently associated with an increased risk of cognitive disorders, and brain insulin resistance could play a role in Alzheimer's disease (AD) pathogenesis.21897007
AtherosclerosisDeregulated Nutrient SensingIn this analysis we utilized existing data from the Insulin Resistance and Atherosclerosis Study (IRAS).21898383
Fetal Growth RetardationDeregulated Nutrient SensingPrior to the development of whole body insulin resistance, young men with IUGR are characterized by increased in vivo adipose tissue lipolysis and blood flow with a paradoxically decreased expression of lipases compared with CON, and 10 days of physical inactivity underlined the baseline findings.21903886
Nodular glomerulosclerosis, Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingNodular glomerulosclerosis in a non-diabetic hypertensive smoker with dyslipidemia.21904413
Dyslipidemias, diabetic, Obesity, Hypertension, CTCAE, DiseaseDeregulated Nutrient SensingDiabetic patients were older and had higher prevalence of obesity, hypertension, dyslipidemia, and associated CV diseases than nondiabetic individuals (P<0.001).21905043
Hypertension, CTCAEDeregulated Nutrient SensingHypertension is associated with impaired glucose tolerance and insulin resistance.21906391
Refractory anemiasDeregulated Nutrient SensingIn patients with RA, cumulative GC dose was associated with T2DM, which seemed mostly driven by the effects of cumulative GC dose on insulin resistance; however, the association decreased when corrected for current disease activity.21908880
Malignant NeoplasmsDeregulated Nutrient SensingAKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.21909130
NeoplasmsDeregulated Nutrient SensingImportantly, the demonstration that mTORC1 is an essential mediator of AKT-induced senescence raises the possibility that targeting mTORC1 in tumours with activated PI3K/AKT signalling may exert unexpected detrimental effects due to inactivation of a senescence brake on potential cancer-initiating cells.21909130
Parapsoriasis en Plaques, DyslipidemiasDeregulated Nutrient SensingThe results of this study suggest that dyslipidemia increases the risk of plaque-type pathology.21911734
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), b-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes.21911752
Ischemic strokeDeregulated Nutrient SensingInsulin resistance is associated with a poor response to intravenous thrombolysis in acute ischemic stroke.21911778
Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance (IR) may not only increase stroke risk, but could also contribute to aggravate stroke prognosis.21911778
Obesity, Bipolar DisorderDeregulated Nutrient SensingLongitudinal study of depressive symptoms and progression of insulin resistance in youth at risk for adult obesity.21911779
Diabetes Mellitus, Non-Insulin-Dependent, Bipolar DisorderDeregulated Nutrient SensingResearch is needed to determine whether early intervention to decrease elevated depressive symptoms in youth ameliorates later development of insulin resistance and lessens the risk of type 2 diabetes.21911779
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, MS gene, ObesityDeregulated Nutrient SensingObesity is often associated with increased serum alanine aminotransferase (ALT), and elevation of ALT is a marker of non-alcoholic fatty liver disease which is caused in part by insulin resistance, the essential characteristic of metabolic syndrome (MS).21912108
HypoadiponectinemiaDeregulated Nutrient SensingOur findings suggest that hypoadiponectinemia is strongly associated with the risk of MS independent of insulin resistance.21912966
Kidney DiseasesDeregulated Nutrient SensingImpact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients.21913955
Chronic Kidney DiseasesDeregulated Nutrient Sensing25(OH)D deficiency is associated with insulin resistance in CKD.21913955
Atrial Fibrillation, Dyslipidemias, Atrial Fibrillation by ECG Finding, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, an important risk factor for cardiovascular disease, may be associated with atrial fibrillation (AF).21914959
Demographics Domain, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThe objective of this paper is to detect the incidence of insulin resistance (IR) in Chronic Kidney disease (CKD) patients and the presence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) in patients with/without IR.21917122
Metabolic Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingCarbohydrate metabolism disorder and insulin resistance are found in patients with CKD.21917122
Hyperleucinemia, Inflammation, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingHyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men.21920718
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTwenty-one adults with poorly controlled type 2 diabetes and insulin resistance who were referred to the clinic between July 1, 2007, and June 30, 2008, and whose therapy was changed from large doses of U-100 insulin to U-500 insulin.21923457
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and visceral adiposity are predisposing factors for fatty liver disease.21923735
DamageDeregulated Nutrient SensingInsulin resistance (IR) contributes to the pathogenesis of impaired glucose tolerance and participates to the development of subclinical organ damage.21925746
Endothelial dysfunctionDeregulated Nutrient SensingAPPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.21926268
Diastolic blood pressure, Diabetes MellitusDeregulated Nutrient SensingPatients in the SCH group had a higher proportion of women, older age, longer duration of diabetes, higher systolic and diastolic blood pressure, and higher insulin resistance index compared with the euthyroid group.21931224
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is associated with altered NF-kB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS.21931634
Diabetes MellitusDeregulated Nutrient SensingAMPK phosphorylation increased in volunteers with NGT, but not in those with diabetes.21931634
Steatohepatitis, Hepatitis CDeregulated Nutrient SensingHepatic steatosis (HS) is highly prevalent in chronic hepatitis C and is an important variable predicting progression of histological injury, insulin resistance, and reduced response to antiviral therapy.21934202
ObesityDeregulated Nutrient SensingA distinct clustering of cardiometabolic responses supports the etiological importance of both overall and central obesity and insulin resistance in the modification of cardiometabolic risk in obese youths.21936669
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe mean values for HbA1c were higher in the diabetes (6.2%) and glucose intolerance groups (5.8%) than in the normal group (5.5%).21937392
Inflammation, Diabetes MellitusDeregulated Nutrient SensingChronic inflammation contributes to insulin resistance and type 2 diabetes mellitus (T2DM).21938543
Insulin Resistance, ObesityDeregulated Nutrient SensingAltogether these data suggest that in conditions of insulin-resistance and obesity there is an up-regulation of myeloid DCs that might contribute to pathological vascular remodeling.21940050
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingTo study the relationship between serum leptin and insulin resistance, and to analyze the effect of acupuncture on serum leptin level in patients with type-II diabetes mellitus (DM).21942183
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPersons who were more educated or who had dyslipidemia or diabetes were more likely than the others to report previous counseling.21943790
Cardiovascular Diseases, Dyslipidemias, Damage, Hypertensive (finding), Chronic Kidney DiseasesDeregulated Nutrient SensingWith respect to those with normal renal function, hypertensive women having CKD were older, showed higher values of blood pressure, and had more frequently dyslipidemia, elevated plasma glucose, target organ damage and cardiovascular disease (P<.001).21944650
Carcinogenesis, ObesityDeregulated Nutrient SensingObesity, deregulation of adipocytokines, and insulin resistance are interrelated and have been implicated in carcinogenesis.21946019
melanomaDeregulated Nutrient SensingIn search of novel risk factors for melanoma, we explored the association of this disease with insulin resistance in a small size, case-control study.21946019
melanomaDeregulated Nutrient SensingThese findings point to insulin resistance as a potentially independent risk factor for melanoma and need to be confirmed by future larger studies, ideally allowing the control of the directionality of the association.21946019
LipolysisDeregulated Nutrient SensingLipid removal rate is positively correlated with the capacity of adipocytes to break down triglycerides, as assessed through lipolysis, and is inversely related to insulin resistance.21947005
Hyperlipidemia, Dyslipidemias, HereditaryDeregulated Nutrient SensingIn contrast, both lipid removal and storage rates are decreased in non-obese patients diagnosed with the most common hereditary form of dyslipidaemia, familial combined hyperlipidaemia.21947005
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingPersistent dyslipidemia in Austrian patients treated with statins for primary and secondary prevention of atherosclerotic events - Results of the DYSlipidemia International Study (DYSIS).21947362
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingWhen the subjects were divided into five groups (0-4) according to the number of metabolic factors (obesity, diabetes, hypertension and dyslipidemia), PEDF levels in patients with four factors were significantly higher than those in patients without factors.21947986
Benign prostatic hypertrophyDeregulated Nutrient SensingWe evaluated the correlations between BMI, fasting glucose, insulin, testosterone level, insulin resistance, and prostate size in non-diabetic benign prostatic hyperplasia (BPH) patients with normal testosterone levels.21949470
Hypertension, CTCAEDeregulated Nutrient SensingThe patient had a history of hypertension and insulin resistance and had no history of alcohol abuse.21951092
Glucose Intolerance (disease)Deregulated Nutrient SensingThe progression of glucose intolerance from NGT to pre-T2DM and T2DM exhibits striking sex differences regarding the lipid profile.21951548
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia and the risk of incident hypertension in a population of community-dwelling Brazilian elderly: the Bambui Cohort Study of Aging.21952856
Malignant tumor of exocrine pancreas, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingOur data on HbA(1c) show that individuals who develop exocrine pancreatic cancer tend to have moderate increases in HbA(1c) levels, relatively independently of obesity and insulin resistance-the classic and major risk factors for type 2 diabetes.21953276
Hypertensive (finding), Electrocardiogram: myocardial infarction (finding), DyslipidemiasDeregulated Nutrient SensingRelationship of dyslipidemia and uric acid with the risk of myocardial infarction among hypertensive patients in Trinidad.21955256
Hypertensive (finding), Electrocardiogram: myocardial infarction (finding), Dyslipidemias, diabeticDeregulated Nutrient SensingTo study the relationship of dyslipidemia and serum uric acid with the risk of myocardial infarction among the hypertensive type 2 diabetic and non-diabetic patients of Trinidad.21955256
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingHypertensive type 2 diabetics with dyslipidemia had greater occurrence of MI (23.93%) than non-diabetic hypertensive patients (7.67%) (p=0.008).21955256
Hypertensive (finding), Dyslipidemias, diabeticDeregulated Nutrient SensingThe results suggest that there is a greater prevalence of MI in hypertensive type 2 diabetic patients with dyslipidemia than in non-diabetic hypertensive patients in Trinidad.21955256
Inflammation, ETV3 wt AlleleDeregulated Nutrient SensingMetS was found to be associated with markers of insulin resistance (IR), low-grade inflammation, and insufficient fibrinolysis.21955584
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHepatic FGF21 correlated inversely with hepatic AMPK phosphorylation In type 2 diabetes mellitus, combined pioglitazone and exenatide therapy is associated with a reduction in plasma FGF21 levels, as well as a greater decrease in hepatic fat than that achieved with pioglitazone therapy.21956711
ovarian neoplasmDeregulated Nutrient SensingAnticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC.21957481
Dyslipidemias, Diabetic Foot, Coronary heart disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIn the GADA negative group obesity, coronary heart disease, hypertension, syndrome of diabetic foot and dyslipidaemia appeared more frequently (OR = 2.8; 3.1; 6.2 and 2.4).21957594
Hypertensive (finding)Deregulated Nutrient SensingThe effect of quinapril treatment on insulin resistance, leptin and high sensitive C-reactive protein in hypertensive patients.21957896
Arthritis, HIV Infections, Inflammatory polyarthritisDeregulated Nutrient SensingSeropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study.21959060
Refractory anemias, Rheumatoid ArthritisDeregulated Nutrient SensingIn established rheumatoid arthritis (RA), insulin resistance (IR) is increased and associated with CVD.21959060
Weight decreasedDeregulated Nutrient SensingDietary weight loss and exercise effects on insulin resistance in postmenopausal women.21961463
Weight decreasedDeregulated Nutrient SensingDietary weight loss, with or without exercise, significantly improved insulin resistance.21961463
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingWe studied 3,484 older hypertensive patients with dyslipidemia in 6 primary care practices over a 4-year timeframe.21961563
Prostate Cancer Outcomes Study, Disorder of endocrine ovaryDeregulated Nutrient SensingThe PCOS phenotype changed with aging, suggesting an amelioration of the phenotype and ovarian dysfunction as indicated by the increase in number of regular menstrual cycles, decrease in serum androgen levels, and decrease in insulin resistance.21963227
ObesityDeregulated Nutrient SensingInsulin resistance (IR) has been directly related to obesity, particularly central obesity, and to other cardiovascular risk factors (CVRFs).21963533
ETV3 wt AlleleDeregulated Nutrient SensingIn MetS subjects with high HDL-C levels, insulin resistance was increased.21963728
Obesity, AbdominalDeregulated Nutrient SensingHeavy smoking was significantly associated with T2DM, and this association was moderated by CYP2A6 genotype and mediated by serum cotinine, abdominal obesity, insulin resistance, and insulin secretion.21964962
HyperglycemiaDeregulated Nutrient SensingHepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.21965330
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a major risk factor for type 2 diabetes mellitus.21965330
HyperglycemiaDeregulated Nutrient SensingLiver-specific Sirt1 deficiency caused hepatic glucose overproduction, chronic hyperglycemia, and increased ROS production.21965330
Inspiration functionDeregulated Nutrient SensingThe objective of this work was to investigate the influence of inspiratory muscular training, with Threshold, on insulin resistance in elderly people.21973074
Blood GlucoseDeregulated Nutrient SensingThe experimental group had improved insulin resistance, with decreased glycemia and insulin requirements, a lower homeostatic model assessment of insulin resistance, and increased respiratory force and performance.21973074
Inspiration functionDeregulated Nutrient SensingThe small sample does not allow for conclusions, but we can suggest that inspiratory muscular training improves insulin sensitivity in elderly patients with insulin resistance.21973074
HypoglycemiaDeregulated Nutrient SensingInsulin resistance index was improved obviously and no event of hypoglycemia occurred.21977859
Hyperglycemia, Hyperuricemia, Malnutrition, DyslipidemiasDeregulated Nutrient SensingThe occurrence of hyperglycemia, hyperuricemia, and dyslipidemia and of nutritional deficiencies, among them magnesium (19%), vitamin A (15%), vitamin C (16%), iron (9%), b-carotene (3%), and vitamin B12 (3%), was high.21978750
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia is considered one of the most important risk factors for coronary heart disease.21981839
DyslipidemiasDeregulated Nutrient SensingCombination therapy with a statin and a fibrate may be more effective than statin monotherapy for reducing hsCRP, especially in patients with mixed dyslipidemia.21981842
DyslipidemiasDeregulated Nutrient SensingCombination therapy with rosuvastatin and fenofibric acid may be effective for improving the inflammatory biomarker, hsCRP as well as other lipid abnormalities in patients with mixed dyslipidemia and high hsCRP.21981842
Atrial Fibrillation by ECG Finding, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Heart failure, Anemia, Obesity, Cerebrovascular Disorders, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingThe most frequent comorbidities were heart failure (59%), diabetes (48%), myocardial infarction (29%), moderate kidney failure (22%), cerebrovascular disease (19%), hypertension (71%), anemia (62%), atrial fibrillation (34%), dyslipidemia (28%) and obesity (21%).21982043
Hyperglycemia, Electrocardiogram: myocardial infarction (finding), glucose metabolismDeregulated Nutrient SensingThe glucose dysmetabolism in the acute phase of non-diabetic ST-elevation myocardial infarction: from insulin resistance to hyperglycemia.21984048
Acute myocardial infarction, Hyperglycemia, myocardial injuryDeregulated Nutrient SensingIn the setting of acute myocardial infarction, hyperglycemia and acute insulin resistance may represent a stress response to myocardial injury mainly related to acute catecholamine release.21984048
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingBy measuring glucose values and insulin resistance (Homeostatic Model Assessment index-HOMA), we evaluated in 356 non-diabetic patients with ST-elevation myocardial infarction (STEMI) undergone mechanical revascularization: (a) the acute glycometabolic response by evaluating insulin resistance, glucose levels, and their combination and (b) whether insulin resistance and increased glucose values (and their combination) are able to affect in-Intensive Cardiac Care Unit (ICCU) mortality and complications.21984048
Degenerative polyarthritis, Tumor necrosisDeregulated Nutrient SensingExposing human osteoarthritic (OA) chondrocytes to tumor necrosis factor a (TNFa) generates a stable and enzymatically inactive 75-kd form of SirT1 (75SirT1) via cathepsin B-mediated cleavage.21987377
Tumor necrosisDeregulated Nutrient Sensing75-kd sirtuin 1 blocks tumor necrosis factor a-mediated apoptosis in human osteoarthritic chondrocytes.21987377
Gestational DiabetesDeregulated Nutrient SensingResistin may not associate with gestational diabetes mellitus although insulin resistance.21995154
Gestational DiabetesDeregulated Nutrient SensingAlthough mean BMI in GDM was higher than in NGDM and insulin resistance in GDM was more marked than in NGDM, serum resistin levels in GDM were not found to be any different from NGDM.21995154
HaploinsufficiencyDeregulated Nutrient SensingThe consequences of growth hormone-releasing hormone receptor haploinsufficiency for bone quality and insulin resistance.21995288
Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingInsulin resistance and atrial fibrillation (from the Framingham Heart Study).21996140
Obesity, Diabetes MellitusDeregulated Nutrient SensingBoth diabetes and obesity are associated with insulin resistance.21996140
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingAt least one dyslipidemia was observed among 212 (66%) including hypercholesterolemia in 121 (38%), high LDL in 135 (42%), hypertriglyceridemia in 110 (34%), and low HDL in 48 (15%) patients.21996228
Hypertensive (finding), Dyslipidemias, Overweight, diabeticDeregulated Nutrient SensingThe subjects with dyslipidemia were prone to be older, to have CAD before OHT, and to be hypertensive, overweight, and obese, as well as display an higher HbA1C when diabetic.21996228
DyslipidemiasDeregulated Nutrient SensingThe aim of the study was to describe the occurrence of dyslipidemias among OHT recipients after introduction of guidelines suggesting the use of statins in all individuals able to tolerate this therapy.21996228
DyslipidemiasDeregulated Nutrient SensingDespite almost universal use of statins, dyslipidemias were present in 2/3 of OHT recipients.21996228
Ischemic strokeDeregulated Nutrient SensingFasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults.21998054
Ischemic strokeDeregulated Nutrient SensingWe investigated whether fasting and post-glucose load measures of insulin resistance were related to incident ischemic stroke in nondiabetic, older adults.21998054
Ischemic strokeDeregulated Nutrient SensingIn nondiabetic, older adults, insulin resistance measured by Gutt index or 2-hour glucose, but not by fasting insulin, was associated with risk of incident ischemic stroke.21998054
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, ObesityDeregulated Nutrient SensingIncrease in obesity and metabolic syndrome are associated with increases in insulin resistance (IR) and type 2 diabetes mellitus.21999398
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingGender, prevalence of hypertension, and dyslipidemia and alcohol intake were not different between the patients with PAD and those without PAD.22000526
Dyslipidemias, OverweightDeregulated Nutrient SensingAmong men, the prevalence ratios of overweight, consumption of meat with visible fat, and dyslipidemia were higher among men with more schooling, while tobacco use, sedentary lifestyle, and high-blood pressure were lower.22002149
Liver Failure, Acute, HypertrophyDeregulated Nutrient SensingA novel therapy of inducing hepatocyte hypertrophy by activating Akt/mTORC1 pathway in acute liver failure.22004987
GTF2A1L wt Allele, HypertrophyDeregulated Nutrient SensingWe hypothesized, therefore, that pharmacological therapy targeting to induce hepatocyte hypertrophy by activating the Akt/mTORC1 pathway might be a novel and promising option in the early management of patients with ALF as an alternative way to impaired process of cell proliferation.22004987
Dyslipidemias, Tacca leontopetaloides, Thrombosis of renal artery, Transient Ischemic Attack, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingCompared to patients without previous TIAs (non-TIA group), patients with previous TIAs (TIA group) were significantly more likely to have hypertension (76.3% vs 64.3%; P = .016), dyslipidemia (57.0% vs 41.1%; P = .003), chronic kidney disease (28.1% v 15.1%; P = .001), intracranial major artery stenosis (51.8% vs 36.2%; P = .018), and large artery atherothrombosis (43.9% vs 28.3%; P = .002).22005036
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes, hypertension, dyslipidemia and previously known CAD, type of MI (STEMI vs NSTEMI) and extent of CAD did not predict cerebrovascular risk.22005309
Hypertension, CTCAE, Kidney Failure, ObesityDeregulated Nutrient SensingHigher hypertension risk, present in 42.5% of the overall group of eligible patients (164/387), is associated with high PTH and high RRI, along with greater renal insufficiency, insulin resistance, and obesity.22007967
Hypertensive (finding), ObesityDeregulated Nutrient SensingEffects of telmisartan on insulin resistance and visceral fat distribution in Chinese hypertensive patients with obesity.22008920
millicurie, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingOur results suggest that esRAGE may be a potential protective factor for dyslipidemia, atherosclerosis, and MCI in patients with type 2 diabetes.22011410
Hypertension, CTCAE, Cardiovascular Diseases, Hyperuricemia, Diabetes MellitusDeregulated Nutrient SensingHyperuricemia is associated with several risk factors for cardiovascular diseases such as hypertension, insulin resistance, and diabetes.22011411
Obesity, Abdominal, Hypertriglyceridemia, Dyslipidemias, Obesity, OverweightDeregulated Nutrient SensingHypertriglyceridemia (52%), low HDL (72.8%), abdominal obesity (60.3%), MS (58.1%), dyslipidemia (88.8%), overweight (74.3%) and obesity (33.8%) were also elevated.22011854
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingConversely, carriers of the TNF-a A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes.22012292
DyslipidemiasDeregulated Nutrient SensingWhether the anti-atherosclerotic effect of cilostazol is independent of improving pro-atherogenic dyslipidemia is worth further investigation.22015232
Erectile dysfunctionDeregulated Nutrient SensingAddition of metformin to sildenafil treatment for erectile dysfunction in eugonadal nondiabetic men with insulin resistance.22016348
Abnormal circulating valine concentration, Endothelial dysfunctionDeregulated Nutrient SensingInsulin resistance (IR) is a metabolic abnormality that produces endothelial dysfunction characterized by decreased synthesis and release of NO.22016348
Biliary calculiDeregulated Nutrient SensingInsulin resistance as a risk factor for gallbladder stone formation in Korean postmenopausal women.22016589
Biliary calculi, ObesityDeregulated Nutrient SensingIn an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group.22016589
Obesity, Abdominal, Biliary calculiDeregulated Nutrient SensingInsulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.22016589
Chronic Obstructive Airway Disease, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMost patients were male (52%) and had hypertension (84%) and dyslipidemia (84%), with 24% having diabetes mellitus and 20% chronic obstructive pulmonary disease.22017933
ObesityDeregulated Nutrient SensingClassically activated macrophage accumulation in adipose tissue is a known feature of obesity, where it is linked with increasing insulin resistance.22018099
Chronic heart failureDeregulated Nutrient SensingStudy of insulin resistance, TNF-a, total antioxidant capacity and lipid profile in patients with chronic heart failure under exercise.22021702
Congestive heart failureDeregulated Nutrient SensingAll non-diabetic CHF patients were characterized by insulin resistance.22021702
Cardiovascular DiseasesDeregulated Nutrient SensingThere are many pathophysiological mechanisms underlying reciprocal relationships between changes in cytokines and insulin resistance in metabolic and cardiovascular disorders.22024218
Tumor necrosisDeregulated Nutrient SensingIn addition, significant decreases were found in plasma tumor necrosis factor a (P < .01), which might have contributed to the improvements observed in insulin resistance.22024489
Obesity, AbdominalDeregulated Nutrient SensingInsulin resistance, low cardiorespiratory fitness, and increased exercise blood pressure: contribution of abdominal obesity.22025379
Systolic PressureDeregulated Nutrient SensingIndividuals with an increased waist circumference (>=94 cm and >=80 cm for men and women, respectively) had higher exercise systolic blood pressure compared with individuals with low waist circumference, irrespective of their level of insulin resistance (10.6 versus 6.8, 12.2 versus 7.7, and 13.2 versus 8.7 mm Hg/metabolic equivalent, respectively, for the low, intermediate, and high tertiles; P<0.05) or fitness levels (13.1 versus 8.2, 12.0 versus 7.9, and 10.6 versus 7.1 mm Hg/metabolic equivalent, respectively, for the low, intermediate, and high tertiles; P<0.05).22025379
Hepatitis, Obesity, Fatty Liver DiseaseDeregulated Nutrient SensingIL-1RA serum levels associate with liver inflammation and serum ALT independently of obesity, alcohol consumption and insulin resistance, suggesting a potential use of IL-1RA as a non-invasive inflammatory marker for NASH.22027586
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThis association with diabetes mellitus mandates screening for glucose intolerance in all patients with NL.22031644
Communicable DiseasesDeregulated Nutrient SensingPrevious reports have indicated that insulin resistance (IR) is associated with chronic hepatits C virus (HCV) infection.22035893
TG gene, Coronary ArteriosclerosisDeregulated Nutrient SensingThe ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups.22037512
Dyslipidemias, Dysglycemia, ObesityDeregulated Nutrient SensingSubstantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans.22039493
Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingDyslipidemia was associated with male gender, age, a family history of dyslipidemia, education at college or above, current smoker, overweight and obesity, intermediate and high waist circumference, hypertension and diabetes.22041495
TG gene, DyslipidemiasDeregulated Nutrient SensingThe major type of dyslipidemia in Beijing is high LDL-C rather than high TG.22041495
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingA comprehensive strategy toward the prevention, screening, treatment, and control of dyslipidemia is needed to slow the epidemic of cardiovascular disease.22041495
Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance in dialysis versus non dialysis end stage renal disease patients without diabetes.22043573
Uremia, Kidney Failure, Chronic, Chronic kidney disease stage 5Deregulated Nutrient SensingInsulin resistance is frequently recognized in uremic patients and is a predictor of cardiovascular mortality in end stage renal disease (ESRD) patients.22043573
Kidney Failure, Chronic, Diabetes MellitusDeregulated Nutrient SensingHowever sparse data are available regarding the effects of different methods of renal dialysis on insulin resistance in ESRD without diabetes.22043573
Kidney Failure, Chronic, Diabetes MellitusDeregulated Nutrient SensingThe present study was conducted to evaluate the levels of insulin resistance in dialysis versus non dialysis ESRD patients without diabetes.22043573
Communicable Diseases, Liver carcinoma, HepatitisDeregulated Nutrient SensingChronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma.22044490
Hepatitis A, Hepatitis C, FAM126A geneDeregulated Nutrient SensingInsulin resistance (IR) occurs early in HCV infection and may synergize with viral hepatitis in HCC development.22044490
Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, FAM126A geneDeregulated Nutrient SensingEgypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV genotype-4 (HCV-4) on prevalence of insulin resistance in chronic hepatitis C (CHC) and HCC in Egyptian patients.22044490
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular disease (CVD) risk factors are associated with body mass index z-score (BMISD) and/or insulin resistance (IR).22044843
NDUFAB1 gene, Dyslipidemias, Coronary heart disease, Cerebrovascular accident, Hypertension, CTCAEDeregulated Nutrient SensingEvolution of patients with STEMI after ACP is significantly better in patients with non-anterior location, males, without history of coronary disease, stroke, hypertension, dyslipidemia, ischemic time > 6 hours.22046807
PathologyDeregulated Nutrient SensingHowever, more robust evidence is needed on the effectiveness of Motivational Interviewing in treating chronic pathologies -such as dyslipidemia- in patients assisted by general practitioners.22054017
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMost patients had hypertension (38%) and dyslipidemia (26%); 51% of the patients actively used ICI, with a median of 3 attempts monthly.22055695
Hypertension, CTCAEDeregulated Nutrient SensingThe novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function.22056616
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThey were also more likely to have diabetes mellitus, dyslipidemia, prior AMI, or percutaneous/surgical coronary revascularization.22057047
Proteinuria, Nephrons, DyslipidemiasDeregulated Nutrient SensingLaboratory data showed nephrotic level of proteinuria and dyslipidemia.22057172
Metabolic Syndrome XDeregulated Nutrient SensingThese results suggested that higher GGT and lower HMW adiponectin levels are synergistically associated with metabolic syndrome and insulin resistance.22059425
Diabetes Mellitus, Non-Insulin-Dependent, Mutation-Negative Lynch SyndromeDeregulated Nutrient SensingA fraction of mutation-negative patients presented with insulin-resistance and normal insulin-secretory capacities resembling early-onset type 2 diabetes.22060211
Fatty Liver, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Liver DysfunctionDeregulated Nutrient SensingJapanese males with visceral fat type MS are more likely to have dyslipidemia, fatty liver, and liver dysfunction than those with subcutaneous fat type MS. Visceral fat type MS is one of the most significant risk factors for NAFLD in Japanese males with MS.22065161
Cardiovascular Diseases, Mood Disorders, Dyslipidemias, Behavior Disorders, Diabetes Mellitus, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingWe aimed to evaluate the hypothesis that the presence of an interaction between smoking and being overweight increases the risks of lifestyle-related diseases (hypertension, diabetes mellitus, dyslipidemia, and cardiovascular disease) in outpatients with mood disorders.22065307
Dyslipidemias, OverweightDeregulated Nutrient SensingThere was no interaction of smoking and being overweight with dyslipidemia.22065307
Hypertension, CTCAEDeregulated Nutrient SensingAldosterone plays a role in hypertension, and hypertension is prevalent in patients with insulin resistance.22068870
Chronic Kidney Diseases, Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingIn 50 CKD patients (age 56+-11 years, BMI 25+-4kg/m(2), 46% females, 14% smokers, 86% hypertensives, 52% with dyslipidaemia) the mean vitamin D level was 53+-33nmol/L (21+-13ng/L).22071357
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingSex (P=0.0004), hypertension (P=0.0002), dyslipidemia (P=0.0004) and DM (P=0.0061) were associated with log(CAC+1), respectively.22072111
Sandawe language, TG gene, Blood Glucose, Hyperglycemia, Dyslipidemias, No metabolic abnormalitiesDeregulated Nutrient SensingThough the SAD and WC were associated with numerous metabolic abnormalities, only SAD correlated with dyslipidemia (TG and HDL-c) and hyperglycemia (glycemia).22072363
Weight decreasedDeregulated Nutrient SensingA peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.22072637
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingAtorvastatin treatment do not modify APOE expression, however those individuals without LDL cholesterol goal achievement after atorvastatin treatment according to the IV Brazilian Guidelines for Dyslipidemia and Atherosclerosis Prevention had lower APOE expression than patients with desirable response after the treatment (p < 0.05).22074026
Diabetes MellitusDeregulated Nutrient SensingGrowth hormone (GH) deficiency is associated with insulin resistance and diabetes.22074727
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events.22075538
Endothelial dysfunctionDeregulated Nutrient Sensing[Postprandial lipemia induces endothelial dysfunction and higher insulin resistance in healthy subjects].22078763
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn this study, the most important risk factors were hypertension and dyslipidemia.22078780
Carcinoma of lungDeregulated Nutrient SensingThe nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53.22081070
Carcinoma of lungDeregulated Nutrient SensingThis demonstrates that the pro-oncogenic activity of TR3 in lung cancer cells was due to inhibition of p53 and activation of mTORC1.22081070
Carcinoma of lung, Lung NeoplasmsDeregulated Nutrient SensingDIM-C-pPhOH inhibited growth and induced apoptosis in lung cancer cells and lung tumors in murine orthotopic and metastatic models, and this was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling, demonstrating that inactivators of TR3 represent a novel class of mTORC1 inhibitors.22081070
Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Cessation of life, Hypertensive diseaseDeregulated Nutrient SensingAll the risk factors like, dyslipidemia (90%), HTN (68.8%) past smoker (45%), current smoker (32.5%), diabetes (36.3%), family history of coronary artery disease (25%) and sudden death of first degree relatives (8.8%); dyslipidemia was the highest percentage.22081177
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThe prevalence of dyslipidaemia and the risk of cardiovascular disease are elevated in patients with type 2 diabetes.22081557
Atherosclerosis, Dyslipidemias, Overweight, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOverweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis.22087679
selenium, DyslipidemiasDeregulated Nutrient SensingIn a multivariate regression model (R2 = 0.88), RFQIMT remained significantly associated with the dyslipidemia (regression coefficient +- standard error [SE]: 0.057 +- 0.023; p = 0.017), LVMI (regression coefficient +- SE: 0.01 +- 0.001; P < 0.0001) and number of damaged coronaries (regression coefficient +- SE: 0.0174 +- 0.028; P < 0.0001).22087814
One Vessel Coronary Disease, DyslipidemiasDeregulated Nutrient SensingDividing RFQIMT data in tertiles, dyslipidaemia (31 patients with IMT >= 1.20 mm vs 16 with IMT = 0.91-1.19 vs 25 with IMT <= 0.9, p = 0.004), LVMI (153.5 +- 20.6 g/m2 in IMT >= 1.20 mm vs 131.2 +- 8.4 g/m2 in IMT = 0.91-1.19 mm vs 114.3 +- 11.1 g/m2 in IMT <= 0.9 mm, P < 0.001) and number of high stenosed coronary arteries (IMT >= 1.20 mm population more often showed three vessel diseases than IMT <= 0.90 mm one, P < 0.001) seemed to be significantly related to CCA-IMT increases.22087814
ObesityDeregulated Nutrient SensingUrinary bisphenol A (BPA) concentration associates with obesity and insulin resistance.22090277
ObesityDeregulated Nutrient SensingPrevious studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance.22090277
ObesityDeregulated Nutrient SensingOur objective was to determine whether BPA associates with obesity and insulin resistance.22090277
Obesity, Abdominal, ObesityDeregulated Nutrient SensingBPA was positively associated with generalized obesity, abdominal obesity, and insulin resistance in middle-aged and elderly Chinese adults.22090277
Coronary Artery DiseaseDeregulated Nutrient Sensing[The relationship between amount of cigarette smoked and insulin resistance in male patients with coronary artery disease].22093562
Atherosclerosis of renal artery, Dyslipidemias, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingIn a multivariate Logistic regression model, advanced age, male gender, obesity or overweight, hypertension and dyslipidemia were independently associated with a higher risk of retinal arterial atherosclerosis.22093782
Blood GlucoseDeregulated Nutrient SensingVitamin D supplementation attenuated the increase in glycemia, and increased insulin secretion, but had no effect on insulin resistance.22094836
Arteriopathic disease, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance increases the occurrence of new cardiovascular events in patients with manifest arterial disease without known diabetes.22098712
Arteriopathic disease, Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingIn patients with manifest arterial disease without known diabetes, insulin resistance increases with the number of metabolic syndrome components, and elevated insulin resistance increases the risk of new cardiovascular events.22098712
Increased insulin level, Excessive glucagon secretion, Liver CirrhosisDeregulated Nutrient SensingPatients with liver cirrhosis suffer from hyperinsulinemia, hyperglucagonemia and a certain degree of insulin resistance, and portosystemic shunts may be involved in the etiology.22099870
AcromegalyDeregulated Nutrient SensingThe impact of transsphenoidal surgery on glucose homeostasis and insulin resistance in acromegaly.22101993
Obesity, AtherosclerosisDeregulated Nutrient SensingRecent studies have shown that FABP4 is secreted from adipocytes and that FABP4 level is associated with obesity, insulin resistance, and atherosclerosis.22102888
Dyslipidemias, Hypertension, CTCAE, Obesity, Cerebrovascular accidentDeregulated Nutrient SensingAmong 326 patients (184 males), the most frequent stroke risk factors overall were dyslipidaemia (187), smoking (161), hypertension (105) and obesity (92).22107013
DyslipidemiasDeregulated Nutrient SensingThis analysis supports the view that LDL-P concentration is not increased by POM3 plus atorvastatin, relative to atorvastatin monotherapy, and is associated with potentially favorable shifts in LDL-P subfractions, Apo CIII and lipoprotein-associated phospholipase A(2) in mixed dyslipidemia.22108152
DyslipidemiasDeregulated Nutrient SensingThis could be due to an increased incidence of dyslipidemia.22108412
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingUltrasonographically detected non-alcoholic fatty liver disease is an independent predictor for identifying patients with insulin resistance in non-obese, non-diabetic middle-aged Asian adults.22108448
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingCorneal arcus was not associated with dyslipidemia, diabetes mellitus, arterial hypertension, alcohol consumption, or smoking.22110074
HypercholesterolemiaDeregulated Nutrient SensingThere was a statistically significant reduction in total cholesterolemia (-20%), LDL-C (-31%), and insulin resistance (-10%) with nutraceutical treatment.22113535
DyslipidemiasDeregulated Nutrient SensingAssociation of high Lp() of children of both age groups with atherogenic dyslipidemia of proband-parent requires confirmation.22117675
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia (59%) and hypertension (57%) were the most prevalent risk factors.22118125
HyperlipidemiaDeregulated Nutrient SensingThe S mice were resistant to the inflammatory process, as shown by low immunoreactivity to CD40L, with high plasma HDL levels, and did not develop insulin resistance, even with moderate hyperlipidemia compared to WT.22118127
HyperlipidemiaDeregulated Nutrient SensingThe HF mice showed severe hyperlipidemia, increased cardiac immunoreactivity to CD40L, pronounced morphological changes in the aortic wall and insulin resistance, associated with a decrease in plasma HDL levels, compared to S. This severe hyperlipidemia in the HF mice can be considered the major metabolic factor inducing oxidative stress in the cardiovascular system, increasing the lipid peroxidation of HDL and hence its removal by the liver, with consequent lowering of plasma HDL levels.22118127
Cardiovascular systemDeregulated Nutrient SensingHigh HDL plasma levels are a protective factor against the development of cardiovascular inflammation and insulin resistance in LDLr-/- mice, preventing the development of neointimal lesions.22118127
Communicable Diseases, Hepatitis C, deficiency aspects, Liver CirrhosisDeregulated Nutrient SensingThe relationship between selenium (Se) deficiency and insulin resistance has not much been established in persistent hepatitis C virus (HCV) infection, although Se deficiency is often observed in patients with liver cirrhosis.22118753
Fibrosis Assessment, Lymphoproliferative Disorder of the SkinDeregulated Nutrient SensingWe hypothesized that the decreased serum Se levels were associated with the severity of hepatic fibrosis or insulin resistance in patients with HCV-related chronic liver disease (CLD).22118753
Fibrosis, Liver, deficiency aspectsDeregulated Nutrient SensingThese findings suggest that Se deficiency was associated with the severity of hepatic fibrosis in patients with HCV-related CLD and that Se deficiency was likely to be one of the factors contributing to insulin resistance in those patients.22118753
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia among Nigerian oil workers with type 2 diabetes mellitus.22120488
diabeticDeregulated Nutrient SensingSerum total cholesterol dyslipidaemia, triglyceride dsylipidaemia and low-density lipoprotein cholesterol dyslipidaemia were found in 26.9%, 19.2% and 9.6% of the diabetic subjects respectively.22120488
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia in Nigerian oil workers with T2DM is common and consists mainly of hypertriglycendaemic and low HDL cholesterol.22120488
DyslipidemiasDeregulated Nutrient SensingFactors related to development of dyslipidemia were higher in total cholesterol, female gender with high CD4 count and male gender with low CD4 count (p<0.05).22122388
Movement Disorders, Hyperprolactinemia, Dyslipidemias, Diabetes Mellitus, Psychiatric, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingPsychiatric medications have clear links to obesity, diabetes, dyslipidaemia, hypertension, hyperprolactinaemia and movement disorders.22122654
Dyslipidemias, Cataract, Diabetic Retinopathy, Abnormality of the vasculature, Retinal Vein Occlusion, Glaucoma, CTCAEDeregulated Nutrient SensingDyslipidemia was not significantly associated with the prevalence of glaucoma (P = 0.99), retinal vein occlusions (P = 0.92), diabetic retinopathy (P = 0.49),presence of retinal vascular abnormalities such as focal or general arteriolar narrowing, age-related macular degeneration(P = 0.27), nuclear cataract (P = 0.14), cortical cataract (P = 0.93), and subcapsular cataract (P = 0.67).22128290
Metabolic Syndrome XDeregulated Nutrient SensingVitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance.22129928
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAll subgroups showed high rates of hypertension, dyslipidemia, diabetes, and smoking, with the highest rates observed in the northeast region.22137071
glycation, Diabetes MellitusDeregulated Nutrient SensingPatients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance.22137116
Excessive glucagon secretion, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance, reduced b-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM).22140505
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingThere is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease.22144216
Acanthosis Nigricans, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance.22144216
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWhile analyzing the interaction between DD and the individual risk factor of hypertension, smoking and dyslipidemia, patients with the risk factor and with DD had the highest risk compared to referent patients without the risk factor and with II/ID.22144991
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn conclusion, traditional risk factors (hypertension, smoking and dyslipidemia) play an important role in the association between ACE genotypes and PAD.22144991
ObesityDeregulated Nutrient SensingLeisure time and occupational physical activity in relation to obesity and insulin resistance: a population-based study from the Skaraborg Project in Sweden.22146090
ObesityDeregulated Nutrient SensingThe observed sex differences regarding the strength of the association between LTPA and insulin resistance, and the positive association between OPA and obesity and insulin resistance found solely in women, warrant further investigation.22146090
Liver carcinomaDeregulated Nutrient SensingSIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis.22146883
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingThe purpose of this study is to elucidate the clinicopathological and functional significance of SIRT1 expression in hepatocellular carcinoma (HCC).22146883
FAM126A geneDeregulated Nutrient SensingSIRT1 expression in HCC was determined by immunohistochemical staining.22146883
FAM126A geneDeregulated Nutrient SensingSIRT1 was overexpressed in HCC cell line SK-Hep1 to study its role in tumorigenesis and resistance to chemotherapy.22146883
NeoplasmsDeregulated Nutrient SensingSIRT1 overexpression was associated with higher a-fetoprotein level, higher tumor grade, and absence of b-catenin mutation.22146883
FAM126A geneDeregulated Nutrient SensingSIRT1 expression predicted poor long-term survival for patients with resected HCC.22146883
FAM126A geneDeregulated Nutrient SensingThe elevated SIRT1 protein level in HCC was not attributable to the elevation of mRNA level.22146883
FAM126A geneDeregulated Nutrient SensingSIRT1 is an oncogenic protein for HCC and is a predictor of worse outcome after surgical resection of HCC.22146883
Diabetes MellitusDeregulated Nutrient SensingSeveral insulin receptor substrate-2 (IRS-2) polymorphisms have been studied in relation to insulin resistance and type 2 diabetes.22147666
Malignant tumor of colon, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Cerebrovascular accident, Degenerative polyarthritis, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, stroke, colon cancer and osteoarthritis were selected as obesity-related diseases.22147988
Increased insulin levelDeregulated Nutrient SensingThe more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation.22148099
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingWith a high prevalence of dyslipidemia and pro-inflammatory factors, the population is at substantial risk for cardiovascular diseases.22149059
Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 and the clock gene machinery in colorectal cancer.22149272
CarcinogenesisDeregulated Nutrient SensingSIRT1 and the clock genes are involved in carcinogenesis.22149272
Colorectal CarcinomaDeregulated Nutrient SensingWe evaluated SIRT1 expression in 19 human colorectal cancer (CRC) specimens and clock gene expression in SIRT1-overexpressing CaCo2 and SW480 cells.22149272
Colorectal CarcinomaDeregulated Nutrient SensingIn CRC, SIRT1 mean expression level was decreased.22149272
ARCN1 gene, Impaired healthDeregulated Nutrient SensingThese patients may constitute a specific COPD phenotype with greater leptin to adiponectin imbalance and insulin resistance, despite smaller impairment in PFTs.22149401
Cardiovascular DiseasesDeregulated Nutrient SensingLittle is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested.22151790
Intervertebral Disc DegenerationDeregulated Nutrient SensingSIRT1 treatment significantly reduced aggrecan, Sox9 and collagen type 2 mRNA expression in a dose-dependent manner in all disease classes and disc degeneration grades.22152608
Spinal stenosis of lumbar region, Prolapsed lumbar discDeregulated Nutrient SensingProliferation activity was decreased by SIRT1 treatment in lumbar spinal stenosis and lumbar disc herniation, Pfirrmann grade 3 and grade 4 discs.22152608
Intervertebral Disc DegenerationDeregulated Nutrient SensingSIRT1 affected both extracellular matrix metabolism and proliferation activity; the effect of SIRT1 was altered according to disease class and disc degeneration grade.22152608
Intervertebral Disc DegenerationDeregulated Nutrient SensingSIRT1 appears to play a key role in homeostasis during the human intervertebral disc degeneration process.22152608
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingOverall 63.9% had dyslipidaemia with hypertriglyceridaemia and hypo-HDL being the most common (28% and 45%, respectively), while 2% had hypercholesterolaemia or hyper-LDL.22155918
Fibrosis, Liver, Steatohepatitis, Hepatitis, ChronicDeregulated Nutrient SensingCorrelation between insulin resistance and outcome of pegylated interferon and ribavirin therapy, hepatic steatosis, hepatic fibrosis in chronic hepatitis C-1b and high viral load.22156479
Hepatitis CDeregulated Nutrient SensingInsulin resistance (IR) has been reported to be an independent predictor of treatment outcome in chronic hepatitis C patients.22156479
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingHIV infection and exposure to certain antiretroviral drugs is associated with dyslipidemia and increased risk for coronary events.22156913
Retinal Diseases, Complications of Diabetes Mellitus, Kidney DiseasesDeregulated Nutrient SensingRapamycin is considered for prevention of diabetic complications, such as retinopathy and nephropathy, and acute treatment with rapamycin decreases insulin resistance.22157190
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingIt was somehow forgotten that almost two centuries ago, Claude Bernard discovered "starvation diabetes," as shown later, characterized by glucose intolerance, decreased insulin, increased lipoproteins and ketones, gluconeogenesis and hepatic resistance to insulin.22157190
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, under certain conditions, chronic administration of rapamycin may cause glucose intolerance and even provoke type II diabetes.22157190
Dyslipidemias, Chronic Kidney Insufficiency, Hypertension, CTCAEDeregulated Nutrient SensingHe had a clinical history of hypertension, dyslipidaemia and chronic renal impairment.22157483
DyslipidemiasDeregulated Nutrient SensingPrescription use and frequency of lipid measurement suggested improved control resulting from a targeted approach to managing specific dyslipidemias.22166083
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingIn studies performed in mice, rose hip powder has been shown to both prevent and reverse high-fat diet-induced obesity and glucose intolerance as well as reduce plasma levels of cholesterol.22166897
Insulin resistance syndromeDeregulated Nutrient SensingNo associations between visfatin and other parameters of the insulin-resistance syndrome as well as macronutrient intake were detectable.22167446
Dyslipidemias, Cerebrovascular accident, Heart Diseases, Acute myocardial infarction, Obesity, Kidney FailureDeregulated Nutrient SensingInferential analysis showed a significant association with history of heart disease, renal failure, dyslipidemia, smoking and obesity, as well as the causes of admission of stroke and acute myocardial infarction.22169369
Fetal Growth Retardation, Diabetes MellitusDeregulated Nutrient SensingWhile the association of IUGR and adult MS, including diabetes, has been well documented, these subjects did not have typical manifestations of MS. Abnormalities in common components that could result in a combination of IUGR, severe postnatal growth, and insulin resistance have been ruled out.22170795
Steatohepatitis, Fibrosis AssessmentDeregulated Nutrient SensingIn genotype-1 infected patients, SVR was associated with a lower grade of liver steatosis, milder fibrosis, and an absence of insulin resistance.22171144
Sleep Apnea, ObstructiveDeregulated Nutrient SensingDisorders of glucose metabolism and insulin resistance in patients with obstructive sleep apnoea syndrome.22171909
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) and disorders of glucose metabolism (DGM) are risk factors for cardiovascular diseases.22171909
OverweightDeregulated Nutrient SensingAmong the overweight or obese children, the boys with the increased ALT level had higher BMI, waist circumference, blood pressure, triglyceride, low density lipoprotein and insulin resistance index than the boys with normal ALT level (P<0.05); the girls with the increased ALT level had higher waist circumference, blood pressure and insulin resistance index and lower high density lipoprotein than the girls with normal ALT level (P<0.05).22172257
Metabolic Diseases, Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingALT is correlated with overweight and obesity and metabolic disorders caused by overweight and obesity such as dyslipidemia and insulin resistance.22172257
Inflammation, Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingApolipoprotein E gene polymorphisms are strong predictors of inflammation and dyslipidemia in rheumatoid arthritis.22174202
Refractory anemias, Inflammation, DyslipidemiasDeregulated Nutrient SensingDyslipidemia in RA may be driven by inflammation and genetic factors.22174202
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and excess risk of diabetes in Mexican-Americans: the San Antonio Heart Study.22174423
Diabetes MellitusDeregulated Nutrient SensingMexican-Americans have more diabetes than non-Hispanic whites, but the extent to which insulin resistance and insulin secretion explain the ethnic difference is unknown.22174423
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance accounts for a large and significant proportion of the excess risk of diabetes in Mexican-Americans.22174423
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAfter controlling for age, the rates of abdominal obesity, family history of diabetes, dyslipidemia and hypertension increased from 21.56% (1715/7956), 4.39% (349/7956), 26.34% (2096/7956) and 11.53% (917/7956) to 31.88% (2706/8487), 12.84% (1090/8487), 41.38%(3512/8487) and 14.61% (1240/8487) respectively (kh(2) = 5.52, 14.83, 18.38 and 20.22, P < 0.01).22177305
Obesity, Abdominal, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFor diabetes, the PARP of aging, dyslipidemia and abdominal obesity were 41.55%, 29.25% and 25.10% respectively.22177305
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAsthma (10.8%), hypertension (10.4%) and dyslipidaemia (9.8%) were the main chronic conditions.22178521
Hypertension, CTCAE, PrehypertensionDeregulated Nutrient SensingInsulin resistance, prehypertension, hypertension and blood pressure values in paediatric age.22179078
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffects of pinitol on glycemic control, insulin resistance and adipocytokine levels in patients with type 2 diabetes mellitus.22179130
diabeticDeregulated Nutrient SensingWe evaluated the effects of pinitol on glycemic control, insulin resistance and adipocytokine levels in type 2 diabetic patients.22179130
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPinitol can mediate insulin action to improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus, especially in patients with insulin resistance.22179130
Non-alcoholic Fatty Liver Disease, Cardiovascular DiseasesDeregulated Nutrient SensingIt has been observed that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease and insulin resistance.22181832
Acute lymphocytic leukemiaDeregulated Nutrient SensingThe prevalence of insulin resistance and other cardiometabolic risk factors is increased in ALL survivors, and insufficient physical activity (PA) and low cardiopulmonary fitness are common.22184098
diabeticDeregulated Nutrient SensingIn addition, lymphocyte levels of HO-1, Hsp70, Trx and TrxR-1 (P<0.05 and P<0.01) in diabetic patients were higher than in normal subjects, while sirtuin-1 and sirtuin-2 protein was significantly decreased (p<0.05).22186191
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPolymorphism of adiponectin (45T/G) and adiponectin receptor-2 (795G/A) in an Iranian population: relation with insulin resistance and response to treatment with pioglitazone in patients with type 2 diabetes mellitus.22187345
Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing[CoLaus: diabetes and dyslipidemia, there is always something new!].22187780
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThey are associated with well known risk factors such as diabetes and dyslipidemia.22187780
Abnormal circulating valine concentration, Williams SyndromeDeregulated Nutrient SensingThis case demonstrates the early clinical features of WS and suggests that metabolic abnormality, including insulin resistance, is not an essential component of WS at disease onset.22188495
Atrial Fibrillation, DyslipidemiasDeregulated Nutrient SensingWe compared the efficacy and safety of atorvastatin (A-group, n = 43) and pravastatin (P-group, n = 41) as upstream therapy in patients with paroxysmal AF and dyslipidemia.22188709
Hyperparathyroidism, PrimaryDeregulated Nutrient SensingPrimary hyperparathyroidism (pHPT) is characterized by an increased frequency of glucose tolerance abnormalities associated with insulin resistance.22189414
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension, diabetes mellitus, and dyslipidemia were more common in the middle-aged group (p<0.05).22189478
Hyperandrogenemia, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn women with PCOS, hyperandrogenemia appears to diminish during reproductive life whereas insulin resistance worsens.22192350
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRisk factors included smoking (47%), hypertension (70%), dyslipidemia (66%), and diabetes mellitus (25%).22192370
Arterial StiffnessDeregulated Nutrient SensingInsulin resistance and arterial stiffness in healthy adolescents and young adults.22193511
Arterial Stiffness, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased arterial stiffness is a risk factor for adverse cardiovascular events in adults with obesity-related insulin resistance (IR) or type 2 diabetes mellitus.22193511
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia were also paradoxically associated with better survival in our model (HR 0.74, CI 0.59-0.92; and HR 0.77, CI 0.63-0.94; respectively; both P < .05).22196843
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus type 2 with dyslipidemia is a common disease.22198821
Calcification of coronary arteryDeregulated Nutrient SensingSIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients.22200427
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInfluence of lifestyle habits, nutritional status and insulin resistance in NAFLD.22201932
Fatty Liver Disease, Non-alcoholic Fatty Liver Disease, Obesity, Diabetes MellitusDeregulated Nutrient SensingNon alcoholic fatty liver disease (NAFLD) is associated with obesity, diabetes and insulin resistance (IR).22201932
DyslipidemiasDeregulated Nutrient SensingThese data suggest that an increased cadmium body burden increases the risk of dyslipidemia, mainly due to the increased risk of low HDL-C and the high ratio of triglycerides to HDL-C.22208951
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt has been suggested that sex steroid hormones may play a causal role in the development of insulin resistance and type II diabetes.22211848
Presenile dementia, Inflammation, "Alzheimers DiseaseDeregulated Nutrient SensingBiomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.22213409
Glucose Intolerance (disease)Deregulated Nutrient SensingWe conclude that MS is associated with an altered hemorheological profile related to inflammatory, lipidic and glucose intolerance parameters which could favor the development of thrombo-embolic and athero-thrombotic events in MS patients.22214720
Primary malignant neoplasmDeregulated Nutrient SensingInsulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up.22215126
Primary malignant neoplasm, Diabetes Mellitus, Metabolic Syndrome X, ObesityDeregulated Nutrient SensingAge- and sex-adjusted analysis showed that hyperinsulinemia/insulin resistance is associated with cancer mortality independently of diabetes, obesity/visceral obesity and the metabolic syndrome.22215126
Prediabetes syndromeDeregulated Nutrient SensingIn 108 adolescents, diagnoses included 40.7% with T2DM, 25.0% with prediabetes, and 34.3% with insulin resistance.22217471
Dyslipidemias, Deep thrombophlebitis, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingUnivariate linear models showed that obesity (p=0.010), dyslipidemia (p=0.004), arterial hypertension (p=0.046), use of platelet anti-aggregating agents (p=0.018) and DVT (p<0.001) were associated to lower levels of FMD.22217989
Dyslipidemias, Deep thrombophlebitisDeregulated Nutrient SensingUnivariate logistic regression models showed that dyslipidemia (p=0.008), use of platelet anti-aggregating agents (p=0.004) and DVT (p<0.001) were associated to a higher risk of having FMD <= 8.5%.22217989
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAge of risk for CAD were found in 30.0%, hypertension in 55.0%, diabetes in 10.0%, smoking in 35.0%, dyslipidemia in 67.5% and family history of CAD in 57.5%.22218509
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and g-GT activity were significantly higher in NASH subjects.22219597
Subarachnoid HemorrhageDeregulated Nutrient SensingAdiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage.22230897
Cerebral VasospasmDeregulated Nutrient SensingAdiponectin plays an important role against cerebral vasospasm via the AMPK/eNOS signaling pathway.22230897
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine the benefit of neutral protamine Hagedorn (NPH) insulin compared with insulin glargine in a patient with type 2 diabetes mellitus and severe insulin resistance.22232027
Cardiac Hypertrophy, AcromegalyDeregulated Nutrient SensingNewly diagnosed acromegalic patients without cardiac hypertrophy display a decreased sympathetic outflow in spite of insulin resistance.22233452
Dyslipidemias, Coronary Arteriosclerosis, HypothyroidismDeregulated Nutrient SensingHypothyroidism is a well-known cause of secondary dyslipidaemia and may therefore predispose to the development of atherosclerotic disease.22236619
Thyroid dysfunction, DyslipidemiasDeregulated Nutrient SensingIn addition, these cases demonstrate that clinical and biochemical screening for thyroid dysfunction is of paramount importance in all dyslipidaemia patients to prevent inappropriate initiation of lipid-lowering therapy.22236619
Chronic Lymphocytic LeukemiaDeregulated Nutrient SensingThe results showed: (1) HDAC isoenzyme levels in CLL were significantly increased in class I including HDAC1 and HDAC3, in class II including HADC6, HDAC7, HDAC9 and HDAC10, and in class III including SIRT1 and SIRT6; (2) higher expression of HDAC isoenzyme levels was found in ZAP-70+ compared to ZAP-70- patients, and CD44 expression levels were correlated with HDAC isoenzyme expression levels in the majority of HDAC classes.22237050
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with type 2 diabetes.22237690
Hepatitis C, ObesityDeregulated Nutrient SensingObesity and insulin resistance have been reported as negative predictors for sustained virological response (SVR) in hepatitis C virus (HCV) genotype 1 infected patients treated with pegylated interferon-a plus ribavirin.22239510
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingHowever, it is still unclear whether RHR can also be applied as a screening for other risk factors, such as hyperglycemia and dyslipidemia.22239980
Increased insulin levelDeregulated Nutrient SensingThis study confirms that red cell aggregability is associated with insulin resistance and hyperinsulinemia, but plasma viscosity seems to be more related to overall glucose tolerance than to either SI or insulinemia.22240354
Diabetes MellitusDeregulated Nutrient SensingThe findings indicate that both MRT and ERT lead to decreased insulin resistance in people with a risk of developing type 2 diabetes; MRT led to a greater increase in glucose uptake capacity (in muscles), whereas ERT led to greater insulin sensitivity, supporting the recommendation of both MRT and ERT as primary intervention approaches for individuals at a risk of developing type 2 diabetes.22240549
Chronic heart failure, Endothelial dysfunctionDeregulated Nutrient SensingChronic heart failure is associated with endothelial dysfunction and insulin resistance.22241951
Diabetes Mellitus, Non-Insulin-Dependent, Heart Failure, SystolicDeregulated Nutrient SensingSystolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake.22241951
diabeticDeregulated Nutrient SensingVisceral fat mass is always, but adipokines (adiponectin and resistin) are diversely associated with insulin resistance in Chinese type 2 diabetic and normoglycemic subjects.22244787
Weight Gain, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAmong the general population, weight gain, and baseline insulin resistance are predictors for NAFLD incidence.22245895
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingIt has been suggested that association between hypothyroidism with dyslipidemia might be present already at the stage of normal thyroid function through altered insulin sensitivity.22246849
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingAbdominal obesity rather than atherogenic dyslipidemia was the primary cause of chronic inflammatory status.22246850
DyslipidemiasDeregulated Nutrient SensingProtein oxidative stress and dyslipidemia in dialysis patients.22248198
Inflammation, DyslipidemiasDeregulated Nutrient SensingHemodialysis patients had increased protein OS and associations of inflammation and dyslipidemia were also observed in these dialysis groups.22248198
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome XDeregulated Nutrient SensingThe association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children.22249092
AURKAIP1 gene, Glucose Intolerance (disease), Autoimmune PancreatitisDeregulated Nutrient SensingGlucose intolerance is often observed in autoimmune pancreatitis (AIP), although its long-term prognosis after steroid treatment (ST) is still unclear.22249131
Eruptive xanthoma, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes was discovered only after the appearance of cutaneous eruptive xanthomata, which appeared due to the previously undiagnosed genetic dyslipidemia.22251869
Dyslipidemias, Kidney Failure, Diabetes MellitusDeregulated Nutrient SensingPatients with vitD insufficiency had dyslipidemia and diabetes more frequently.22252845
Lipodystrophy, DyslipidemiasDeregulated Nutrient SensingTreated HIV-1-infected patients with lipodystrophy often develop insulin resistance and proatherogenic dyslipidaemia.22256965
Diabetes MellitusDeregulated Nutrient SensingPrimary outcomes are changes in insulin resistance and BMI after 12 months; secondary outcomes include changes in diet patterns, physical activity, waist circumference, and perceived risk of developing diabetes.22257365
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingHypertension, dyslipidemia and overweight are related to lower testosterone levels in a cohort of men undergoing prostate biopsy.22258063
Demographics Domain, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Overweight, Cardiovascular systemDeregulated Nutrient SensingHypertension, diabetes mellitus (DM), dyslipidemia and overweight are four clinical factors strongly related to cardiovascular illnesses.22258063
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingLevels of testosterone were related to hypertension (P=0.007), dyslipidemia (P=0.013), overweight (P=0.036) and the number of cardiovascular risk factors (P=0.018).22258063
Inflammation, Diabetes MellitusDeregulated Nutrient SensingChronic inflammation and decreased frequency of regulatory T cells (Tregs) in visceral adipose tissue contribute to the propagation of insulin resistance to diabetes mellitus.22262764
Gastritis, Glucose Intolerance (disease), Chronic Obstructive Airway Disease, Depression, CTCAE, Hypertension, CTCAEDeregulated Nutrient SensingShe also suffered from glucose intolerance, gastritis, chronic obstructive pulmonary disease, hypertension and depression as comorbidities.22263389
TG gene, DyslipidemiasDeregulated Nutrient SensingStatins are the standard-of-care therapy for reducing low-density lipoprotein cholesterol (LDL-C) levels; however, combination with other lipid-modifying agents may be necessary to normalize lipid profiles in patients with mixed dyslipidemia who, in addition to high LDL-C, also have high triglycerides (TG) and low levels of high-density lipoprotein cholesterol (HDL-C).22263674
Presenile dementia, Parkinson DiseaseDeregulated Nutrient SensingDementia is associated with insulin resistance in patients with Parkinson's disease.22265943
Parkinson Disease, Presenile dementia, Diabetes MellitusDeregulated Nutrient SensingThe insulin resistance was present in 62% patients with Parkinson's disease with dementia, of whom 30% had also impaired glucose tolerance, 5,6% newly diagnosed Diabetes Mellitus and 26% only Insulin Resistance.22265943
palladium, Presenile dementiaDeregulated Nutrient SensingOur study suggests that PD patients with dementia are two times more likely to have insulin resistance than patients with PD.22265943
Dyslipidemias, HaitiDeregulated Nutrient SensingThe presence of ED was related to HT (OR: 1.805 [1.128-2.887]; p=0.013), DM (OR 3.585 [1.613-7.966]; p=0.001) and Dyslipidemia (OR: 1.928 [1.062-3.500]; p=0.029).22266257
Dyslipidemias, Demographics Domain, HaitiDeregulated Nutrient SensingThe presence and severity of ED correlate with the presence of HT, DM, Dyslipidemia and the number of DVRF.22266257
Feeding behaviorsDeregulated Nutrient SensingThere was no significant relationship between eating behaviour in PWS subjects and the levels of any hormones or insulin resistance, independent of age.22270375
Increased insulin level, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingBecause insulin resistance and compensatory hyperinsulinemia are observed in 50-70% of individuals with PCOS, deregulated insulin signaling in the ovary is considered an important factor in the disease.22275470
Increased insulin level, Hyperamylasemia, ObesityDeregulated Nutrient SensingHyperamylinemia is common in patients with obesity and insulin resistance, coincides with hyperinsulinemia, and results in amyloid deposition.22275486
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOverall, 67.9% of the patients had hypertension, 27.5% were diabetics and 57.4% had dyslipidemia.22275741
Fatty Liver DiseaseDeregulated Nutrient SensingFatty liver disease and insulin resistance may be mediators of this high ferritin-hypertension association.22278211
Migraine DisordersDeregulated Nutrient SensingInsulin resistance correlated with duration of migraine attacks.22278639
Infection caused by Helicobacter pyloriDeregulated Nutrient SensingControlling for insulin resistance, C-reactive protein and interleukin-6 did not attenuate the effect of H. pylori infection.22279028
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe main co-morbidities were hypertension (53.8%), dyslipidemia (47.2%), and hyperglycemia/diabetes mellitus (15.0%).22281230
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance.22283633
FAM126A geneDeregulated Nutrient SensingSignificant correlations of serum adiponectin levels with serum triglyceride levels and insulin resistance were found in the controls, but not in the HCC patients.22287480
Dyslipidemias, Hypertension, CTCAE, atherosclerotic, Diabetes MellitusDeregulated Nutrient SensingAfter adjusting for age, gender, high sensitivity c-reactive protein, serum glucose and the presence of diabetes, hypertension, smoking, dyslipidemia, antidiabetic drugs, lipid-lowering drugs, and atherosclerotic plaques, it was seen that for every 0.1 point increase in WHtR, and for every cm increase in WC, the PWV increased 0.041 and 0.029 m/sec, and C-IMT increased 0.001 mm and 0.001 mm, respectively.22292502
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAlthough the prevalence of hypertension, dyslipidemia and diabetes mellitus were similar between Japan and USA, there was a trend towards fewer patients in Japan displaying a history of coronary revascularization.22293799
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingReceiver operating curve (ROC) analyses showed that WtHR was a better predictor than all other AI for hypertension and dyslipidemia.22293890
HyperglycemiaDeregulated Nutrient SensingChromium appears to improve hyperglycemia and insulin resistance in acutely ill patients and represents a potential new therapy.22297054
Coronary Arteriosclerosis, ObesityDeregulated Nutrient SensingThe protein lipocalin (LCN)-2 is known to be related to insulin resistance, obesity and atherosclerotic diseases.22300286
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDeterminants of uncontrolled dyslipidaemia among adult type 2 diabetes in Malaysia: the Malaysian Diabetes Registry 2009.22305940
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNumerous studies with compelling evidence had shown a clear relationship between dyslipidaemia and cardiovascular (CV) events in patients with diabetes mellitus.22305940
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingThis was an observational study based on secondary data from the online registry database Adult Diabetes Control and Management (ADCM) looking into the determinants of uncontrolled dyslipidaemia in type 2 diabetes mellitus patients.22305940
DyslipidemiasDeregulated Nutrient SensingThis study has highlighted the suboptimal management of diabetic dyslipidaemia in Malaysia.22305940
Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity, insulin resistance (IR), and progressive decline in pancreatic b-cell function are major features of type 2 diabetes mellitus (T2DM).22307870
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMost patients were male (95%), non-Hispanic white (80%), older than 50 (mean+-SD=61+-12) with comorbid hypertension (65%) and dyslipidemia (50%).22307880
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThe finding that improvements in obesity-associated insulin resistance following pioglitazone were associated with increased adipocyte cell surface and systemic adiponectin levels, supports the centrality of AT to the cardiometabolic derangement underlying the development of T2D (Type 2 diabetes) and CVD (cardiovascular disease).22309242
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingHbA1c associates with atherogenic dyslipidemia particularly with TG and TG/HDL-C ratio, but not with TC, HDL-C, or LDL-C. HbA1c is not associated with hs-CRP, and with functional fitness and aerobic endurance.22309488
InflammationDeregulated Nutrient SensingThe impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning.22310233
InflammationDeregulated Nutrient SensingFurthermore, there is evidence that obesity-related physiological states, such as insulin resistance and systemic inflammation, may exacerbate physical functioning problems.22310233
Weight decreased, ObesityDeregulated Nutrient SensingSIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity.22310473
Weight decreasedDeregulated Nutrient SensingSubjects carrying minor alleles at SIRT1 and CLOCK loci (R group) displayed a higher resistance to weight loss and a lower weekly weight loss rate as compared with homozygotes for both major alleles (P group).22310473
Weight decreasedDeregulated Nutrient SensingVariants of both SIRT1 and CLOCK have an additive effect on resistance to weight loss that could be related to the chronotype of the subject, higher plasma levels of ghrelin and less adherence to Mediterranean diet patterns.22310473
Consortium for Molecular and Cellular Characterization of Screen-Detected LesionsDeregulated Nutrient SensingPharmacologic suppression of Akt, but not of TORC1, increases Noxa protein levels and downregulates Bfl-1 protein supporting the conclusion that the inhibition of the Akt pathway, the resulting FOXO3a activation and Noxa upregulation are critical molecular mechanisms underlying RA/IFN-a-dependent MCL cell apoptosis.22311672
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia are potentially modifiable cardiovascular risk factors.22313142
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingWe studied hypertensive outpatients regarding goal attainment in controlling dyslipidemia, according to individual cardiovascular risk profile, following the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines.22313142
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe control of dyslipidemia in hypertensive patients is far from ideal and results are even worse in individuals with CVD.22313142
Cardiac Hypertrophy, Failure (biologic function)Deregulated Nutrient SensingIt has been shown that AMPK activity is increased in cardiac hypertrophy and failure but it is unknown whether changes in subunit composition of AMPK contribute to the altered AMPK activity.22314372
Cardiac Hypertrophy, Heart failureDeregulated Nutrient SensingIn this study, we determined the protein expression pattern of AMPK subunit isoforms during cardiac development as well as during cardiac hypertrophy and heart failure in mouse heart.22314372
DiseaseDeregulated Nutrient SensingWe also compared the findings in failing mouse heart to that of the human failing hearts in order to determine whether the mouse heart is a good model of AMPK in human diseases.22314372
Heart failureDeregulated Nutrient SensingIn summary, the protein level and the isoform distribution of AMPK in the heart change significantly during normal development as well as in heart failure.22314372
Atrial Fibrillation by ECG Finding, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingHypertension was the most important risk factor and other risk factors were smoking, diabetes mellitus, tobacco chewing, ischemic heart disease, dyslipidemia, oral contraceptive pill, alcohol consumption, atrial fibrillation and past history of stroke.22314448
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDespite the low prevalence of hypertension, dyslipidemia and diabetes, their tendency to cluster and the increased prevalence among overweight/obese women highlight the high level of risk of this young female population.22314542
Hypertension, CTCAE, Demographics Domain, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWhen we compared TST level and morbidity, we found significantly more patients with diabetes mellitus (DM), hypertension and dyslipidemia in group with TST below 10 nmol/l.22315154
DyslipidemiasDeregulated Nutrient SensingThese findings suggest that niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and that the mechanism may involve inhibition of DGAT2.22315393
Glucose Intolerance (disease), Hypertriglyceridemia, Hypertension, CTCAEDeregulated Nutrient SensingFor each 5-unit increase in CES-D score, odds increased by 47.6% for having hypertriglyceridemia, by 51.8% for having hypertension, and by 56.7% for having glucose intolerance.22315628
Hyperlipidemia, Glucose Intolerance (disease)Deregulated Nutrient SensingIt is one of the most significant contributors to ill health and an indirect cause of morbidity and mortality resulting from hyperlipidaemia and glucose intolerance.22315858
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOver 50% of participants had hypertension or dyslipidemia and were taking 3 or more medications.22316643
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingIt is often associated with obesity, diabetes and dyslipidemia.22317765
Cessation of life, Glioblastoma Multiforme PathwayDeregulated Nutrient SensingThis ability of CK2-Is to sensitize glioma to TNFa-induced death via multiple mechanisms involving abrogation of NF-kB activation, reactivation of wild-type p53 function and SIRT1 inhibition warrants investigation.22318540
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland.22318870
Steatohepatitis, HypocholesterolemiaDeregulated Nutrient SensingHow this interference results in the frequently observed, genotype-dependent clinical sequelae of hypocholesterolemia, hepatic steatosis, and insulin resistance (IR) remains incompletely understood.22318926
Pheochromocytoma, Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingPheochromocytomas have been described to lead to hyperglycemia and diabetes, due to the suppression of insulin release and increased insulin resistance.22322656
Leukemia, T-CellDeregulated Nutrient SensingHigh expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells.22322739
TRPV6 geneDeregulated Nutrient SensingSIRT1, a nicotinamide adenine dinucleotide(+)-dependent histone/protein deacetylase, plays a crucial role in various physiological processes, such as aging, metabolism, neurogenesis and apoptosis, owing to its ability to deacetylate numerous substrates, such as histone and NF-kB, which is implicated as an exacerbation factor in ATL.22322739
TRPV6 geneDeregulated Nutrient SensingSIRT1 expression in ATL patients was significantly higher than that in healthy controls, especially in the acute type.22322739
TRPV6 geneDeregulated Nutrient SensingSirtinol, a SIRT1 inhibitor, induced significant growth inhibition or apoptosis in cells from ATL patients and leukemic cell lines, especially HTLV-1-related cell lines.22322739
TRPV6 gene, leukemiaDeregulated Nutrient SensingThese results suggest that SIRT1 is a crucial antiapoptotic molecule in ATL cells and that SIRT1 inhibitors may be useful therapeutic agents for leukemia, especially in patients with ATL.22322739
Alzheimers DiseaseDeregulated Nutrient SensingaChE and BuChE inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with Alzheimer disease.22323348
Alzheimers Disease", Loading TechniqueDeregulated Nutrient SensingInsulin resistance (IR) may play a role in most pathogenic processes that promote the development of Late Onset Alzheimer Disease (LOAD).22323348
Dyslipidemias, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingFHT2DH was not associated with risk factors for cardiovascular disease, such as dyslipidemia (OR = 1.12, 95% CI = 0.70-1.79) and FRS (OR = 0.74, 95% CI = 0.40-1.36) when adjusted for gender, age, smoking and obesity.22324835
Glucose Intolerance (disease), Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThese findings suggest that, in patients with CHD, elevated 1hPG increases coronary risk factors and may be a marker for early-stage glucose intolerance.22324971
Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingIn addition, documented presence of ischemic heart disease (IHD), stroke, diabetes mellitus, hypertension and dyslipidemia were determined from medical files.22326028
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMale sex, older age, hypertension, diabetes mellitus, smoking, and dyslipidemia all increased the likelihood of the presence of CAP in univariate analysis (P<0.001).22327064
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOlder age, male sex, dyslipidemia, and diabetes mellitus independently increased the likelihood of the presence of CAP in multivariate analysis (P<0.005).22327064
Hyperparathyroidism, PrimaryDeregulated Nutrient SensingInvestigation of insulin resistance in patients with normocalcemic primary hyperparathyroidism.22327928
Glucose Intolerance (disease)Deregulated Nutrient SensingPatients with NPHPT do not exhibit insulin resistance and glucose intolerance.22327928
NeoplasmsDeregulated Nutrient SensingA small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.22331558
Malignant Neoplasms, NeoplasmsDeregulated Nutrient SensingAlthough ~50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1.22331558
Breast Cancer CellDeregulated Nutrient SensingHere, we report a novel small molecule Inauhzin (INZ) that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.22331558
Data types - AddressDeregulated Nutrient SensingAD may represent a brain-specific form of insulin resistance.22332892
Polycystic Ovary Syndrome, Metabolic Syndrome XDeregulated Nutrient SensingPathophysiology of ovarian hyperthecosis remains poorly understood but the metabolic syndrome observed in most patients suggests that insulin resistance associated with high, postmenopausal LH levels, might play a role as in polycystic ovarian syndrome.22336524
Proteinuria, Chronic Kidney DiseasesDeregulated Nutrient SensingWith each one-unit increment of insulin resistance, the odds ratio of prevalent CKD and proteinuria were raised 1.312-fold (1.114 to 1.545) and 1.278-fold (1.098 to 1.488), respectively.22337909
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMarkers of insulin resistance, lipid/lipoproteins, inflammatory markers, and liver fat increased with visceral adiposity in men and women with and without type 2 diabetes.22337910
Muscle hypotonia, Mucopolysaccharidosis IDeregulated Nutrient SensingWe hypothesized that bed rest decreases muscle mass in older adults by blunting the EAA stimulation of MPS through reduced mTORC1 signaling and amino acid transporter expression in older adults.22338078
Mucopolysaccharidosis IDeregulated Nutrient SensingHowever, bed rest blunted the EAA-induced increase in MPS, mTORC1 signaling, and amino acid transporter protein content.22338078
Mucopolysaccharidosis IDeregulated Nutrient SensingWe conclude that bed rest in older adults significantly attenuated the EAA-induced increase in MPS with a mechanism involving reduced mTORC1 signaling and amino acid transporter protein content.22338078
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe objective of this cross-sectional study was to determine effects of gender on dyslipidemia of type II diabetic patients.22338441
Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingPattern of dyslipidemia in type II diabetic patients were estimated by computing all the four types of dyslipidemia like hypertriglyceridemia, low HDL, increased serum total cholesterol and increased serum LDL.22338441
DyslipidemiasDeregulated Nutrient SensingOur findings demonstrate an association between changes in lipid metabolism and improvement in endothelial function in patients with diabetic dyslipidaemia treated with fenofibrate that may involve the effect of apoB-48 on endothelium-dependent vasodilator function.22341868
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingPitavastatin demonstrates long-term efficacy, safety and tolerability in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia.22345687
Abnormality of mitochondrial metabolism, Metabolic Syndrome X, ObesityDeregulated Nutrient SensingThere is growing evidence that mitochondrial dysfunction may lead to obesity and insulin resistance, which are major components of metabolic syndrome.22354267
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of Type 2 diabetes increased across the apolipoprotein B/apolipoprotein A-I ratio quartiles (1.0%, 1.6%, 2.9%, and 4.8% for the 1st through 4th quartiles, respectively, P < 0.001) and homeostasis model assessment-insulin resistance (HOMA2-IR) also showed an increasing tendency by quartile (P < 0.001).22356423
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes, unlike HNF1A-MODY, is associated with insulin resistance and a characteristic dyslipidaemia.22360925
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingChronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of magnesium deficiency and its association with hypertension, dyslipidemia and type 2 diabetes mellitus.22361711
Demographics DomainDeregulated Nutrient SensingThus, pioglitazone decreased the sympathetic nerve traffic through the improvement of insulin resistance in DM patients with recent MI, which indicate that the sympathoinhibitory effects of pioglitazone may, at least in part, have contributed to the beneficial effects of pioglitazone.22361751
NeoplasmsDeregulated Nutrient SensingAMP-activated protein kinase (AMPK) is an effector of the tumour suppressor LKB1, which regulates energy homeostasis, cell polarity, and the cell cycle.22363791
Breast Carcinoma, Ionizing radiationDeregulated Nutrient SensingSestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.22363791
Primary malignant neoplasmDeregulated Nutrient SensingIonizing radiation (IR), a widely used cancer therapy, is known to increase sestrin expression, and acutely activate AMPK.22363791
Primary malignant neoplasm, Breast CarcinomaDeregulated Nutrient SensingOur results suggest that in breast cancer cells SESN2 is associated with AMPK, it is involved in regulation of basal and IR-induced expression and activation of this enzyme, and it mediates sensitization of cancer cells to IR.22363791
Coronary Artery DiseaseDeregulated Nutrient SensingMicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression.22364258
Conn SyndromeDeregulated Nutrient SensingGenes implicated in insulin resistance are down-regulated in primary aldosteronism patients.22366095
Conn SyndromeDeregulated Nutrient SensingPrimary aldosteronism (PA) patients display an increased incidence of insulin resistance.22366095
Dyslipidemias, BlepharoptosisDeregulated Nutrient SensingDyslipidaemia, specifically atherogenic dyslipidaemia, should be considered as a possible determinant of age-related involutional blepharoptosis.22366541
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCompared with normal group patients, NGT group appeared decrease of pancreases first phase secretes and insulin resistance but not aggravate enough to induce type 2 diabetes.22368797
Bicuspid aortic valveDeregulated Nutrient SensingAnti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease.22370592
Heart DiseasesDeregulated Nutrient SensingSirtuin 1 (SirT1) is a protein deacetylase of the sirtuin family, whose activation appears beneficial for cardiac diseases.22370592
Glucose Intolerance (disease), Malignant Neoplasms, Pancreatic carcinomaDeregulated Nutrient SensingPeriampullary malignant neoplasms have been increasing in Japan, mainly in response to an increase in the incidences of pancreatic cancer, and glucose intolerance due to deterioration of insulin secretion is an important problem.22374239
Hashimoto Disease, Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCarbohydrate metabolism disorders in the form of type 1 diabetes connected with an autoimmune process, as well as type 2 diabetes connected with the increase of the insulin resistance, occured in average of half of the patients with Hashimoto's thyroiditis.22378092
Cancer-related fatigue, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingPrevious studies discovered dyslipidemia (DL) and decreased PON1 activity in chronic renal failure (CRF).22378349
Hypertensive (finding)Deregulated Nutrient SensingThe aim of the study was to estimate changes of insulin resistance and plasma concentrations of adipokines after long-term antihypertensive treatment with telmisartan in obese hypertensive patients.22378488
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis.22378734
Inflammation, Heart failureDeregulated Nutrient SensingHeart failure (HF) is characterized by inflammation, insulin resistance, and progressive catabolism.22379072
EndotheliumDeregulated Nutrient SensingMg is an antioxidant and calcium blocker and in space there is oxidative stress, insulin resistance, and inflammatory conditions with evidence in experimental animals of significant endothelial injuries and damage to mitochondria.22379366
Bipolar Disorder, Diabetes MellitusDeregulated Nutrient SensingUsing baseline data (2000-2004) from the Jackson Heart Study, an African American cohort from the U.S. South (N=5301), we quantified the association of subjective social status with selected cardiovascular risk factors: depressive symptoms, perceived stress, waist circumference, insulin resistance and prevalence of diabetes.22381684
Bipolar DisorderDeregulated Nutrient SensingIndependent of objective measures, subjective social status was significantly inversely associated with depressive symptoms (men and women) and insulin resistance (women).22381684
Hypertensive disease, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe main risk factors for cardiovascular diseases were arterial hypertension (89.4%), dyslipidemia (78.3%), low high-density lipoprotein levels (84.2%) and low physical activity (64.1%).22382216
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHypertension and dyslipidemia were the common risk factors associated with cardiovascular diseases.22382216
Inflammation, Metabolic Process, CellularDeregulated Nutrient SensingBlood triglycerides were not altered after 12 weeks of PIO 15 mg once daily in CAPD patients, but parameters of dysmetabolism were markedly improved, including insulin resistance, inflammation, and adipokine balance, suggesting that PIO could be of value for this high-risk patient group.22383630
Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingChronic kidney disease, insulin resistance, and incident diabetes in older adults.22383749
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance is a complication of advanced CKD.22383749
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance is less well characterized in earlier stages of CKD.22383749
Weight decreasedDeregulated Nutrient SensingIntentional weight loss, primarily by improving insulin resistance, is known to decrease the need for anti-diabetic medications.22384240
Hepatitis CDeregulated Nutrient SensingInsulin resistance is a predictor of poor response to peginterferon/ribavirin in patients infected with the chronic hepatitis C virus (HCV).22387529
Prostate Cancer Outcomes Study, Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA large proportion of women with PCOS also exhibit insulin resistance, b-cell dysfunction, impaired glucose tolerance and/or type 2 diabetes (T2D).22389004
Ulcerative ColitisDeregulated Nutrient SensingLikewise, insulin resistance improved significantly in the IC compared with the UC group.22390448
Weight decreased, Diabetes MellitusDeregulated Nutrient SensingWe developed an inexpensive, culturally sensitive diabetes prevention program that resulted in weight loss, improved HbA1c, and improved insulin resistance in a high-risk Latino population.22390448
Diabetes MellitusDeregulated Nutrient SensingIntrahepatic lipid accumulation is extremely common in obese subjects and is associated with the development of insulin resistance and diabetes.22394502
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese data suggest that the MGAT pathway is active and dynamically regulated in human liver and could be an important target for pharmacologic intervention for the treatment of obesity-related insulin resistance and NAFLD.22394502
DyslipidemiasDeregulated Nutrient Sensing77 men, selected on the basis of increased waist circumference (>=90 cm) and dyslipidaemia (triglycerides >=1.69 and/or high-density lipoprotein (HDL) cholesterol <1.03 mmol/litre), participated in this study.22396182
Fatty degeneration, Skeletal muscle structureDeregulated Nutrient SensingIn contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resistance.22396203
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCommon variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.22396741
ObesityDeregulated Nutrient SensingCommon variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.22397880
Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingUsing univariate logistic-regression analysis, we found that coronary risk factors associated with significant stenosis and high-risk plaque were dyslipidemia (P = 0.033) and current smoking (P = 0.030), respectively.22398672
Prediabetes syndrome, Hypertension, CTCAE, Dyslipidemias, Non-Functioning Pituitary Gland NeoplasmDeregulated Nutrient SensingThe prevalence rates for both patients with nonfunctioning adenoma and sCS were: dyslipidemia: 161 (59%), hypertension: 147 (54%), MS: 128 (47%), prediabetes: 62 (23%), T2DM: 49 (18%), and CVD: 21 (8%).22398948
Diabetes MellitusDeregulated Nutrient SensingAmong participants free of diabetes at baseline, we found a significant positive association with both the homeostatic model assessment for insulin resistance and b-cell function per SD increase in Lp-PLA(2) activity (P values for both <0.01).22399516
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingLp-PLA(2) activity is positively associated with insulin resistance and predicts incident type 2 diabetes among older adults independent of multiple factors associated with diabetes pathogenesis.22399516
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPilot study for the evaluation of morphological and functional changes in retinal blood flow in patients with insulin resistance and/or type 2 diabetes mellitus.22401335
Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to investigate early morphological and functional pathology in the retinal micro-circulation in patients with insulin resistance and/or type 2 diabetes mellitus (T2DM).22401335
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingThe metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease.22402059
Peripheral Arterial DiseasesDeregulated Nutrient SensingInsulin resistance and incident peripheral artery disease in the Cardiovascular Health Study.22402937
Prediabetes syndrome, Peripheral Arterial Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingType 2 diabetes is a risk factor for peripheral artery disease (PAD), and insulin resistance is a key feature of diabetes and pre-diabetes.22402937
Glucose Intolerance (disease), gastrointestinalDeregulated Nutrient SensingThe most prevalent symptoms were hearing loss(68 %), gastro-intestinal problems (59 %), exercise intolerance(54 %) and glucose intolerance (52 %).22403016
Diabetes MellitusDeregulated Nutrient SensingImpact of family history of diabetes on b-cell function and insulin resistance among Chinese with normal glucose tolerance.22404096
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes.22408591
Inflammation, Diabetes MellitusDeregulated Nutrient SensingThe associations between inflammation, diabetes and insulin resistance remain controversial.22409372
Diabetes MellitusDeregulated Nutrient SensingNo association was found between IL-1b levels and all diabetes and insulin resistance markers studied.22409372
TNF protein, human, Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingWe found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-a and hs-CRP, while no association was found with IL-1b.22409372
HyperglycemiaDeregulated Nutrient SensingPostoperative insulin resistance and the consequent hyperglycemia affects clinical outcome.22409999
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThe secular changes presage increases in the prevalence of conditions associated with childhood and adolescent obesity-such as hypertension, glucose intolerance, and dyslipidemia-that may appear as early as the second decade of life.22410970
Diabetes MellitusDeregulated Nutrient SensingVariants of the high-mobility group A1 (HMGA1) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin.22411136
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, HaitiDeregulated Nutrient Sensing13% were type 2 diabetics, 23% had HT and 40% had dyslipidemia.22411383
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe incidence of cardiovascular risk factors in the subjects studied is higher in DM (13%), similar to general population in terms of dyslipidemia (40%) and obesity (23%) and lowest in hypertension (23%).22411383
Primary malignant neoplasmDeregulated Nutrient SensingIt is thought that adipose tissue, particularly visceral fat, which secretes systemic factors that alter immunological, metabolic and endocrine milieu and promotes insulin resistance by producing adipocytokines, is important in cancer progression.22411584
Renal Insufficiency, Postoperative Complications, anemia acuteDeregulated Nutrient SensingCardiac revascularization with extracorporeal circulation is characterized by marked postoperative complications such as insulin resistance, a pro-inflammatory state, acute anemia and renal dysfunction.22414875
Inflammation, Breast Carcinoma, ObesityDeregulated Nutrient SensingThe influence of obesity, vitamin-D status, insulin resistance, inflammation, and elevated adipocytokines in women at high risk of breast cancer is unknown.22415479
deficiency aspects, Diabetes MellitusDeregulated Nutrient SensingAndrogen deficiency in adipocytes in mice resembles human type 2 diabetes, with early insulin resistance and evolving insulin deficiency.22415878
HyperglycemiaDeregulated Nutrient SensingThe relationships between vitamin D concentrations, hyperglycemia, and insulin resistance remain uncertain.22419202
Thrombocytopenia, Dyslipidemias, Osteoporosis, Allergy - Charge Type ReasonDeregulated Nutrient SensingUnfractionated heparin (UFH) is the standard anticoagulant in regular dialysis treatments (RDTs), despite the fact that it may induce thrombocytopenia, dyslipidemia, allergy and osteoporosis.22419236
Dysglycemia, SarcopeniaDeregulated Nutrient SensingSarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III.22421977
Sarcopenia, ObesityDeregulated Nutrient SensingSarcopenia often co-exists with obesity, and may have additive effects on insulin resistance.22421977
Increased insulin level, Impaired cognitionDeregulated Nutrient SensingHyperinsulinemia, insulin resistance and cognitive decline in older cohort.22424621
Increased insulin level, AKAP4 protein, human, Data types - AddressDeregulated Nutrient SensingBut the roles of hyperinsulinemia (HI) and insulin resistance (IR) in the development of AD are still controversial.22424621
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingSerum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance.22424624
InflammationDeregulated Nutrient SensingHigh fat diets increase the risk for insulin resistance by promoting inflammation.22424821
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingElevated IgG levels against specific bacterial antigens in obese patients with diabetes and in mice with diet-induced obesity and glucose intolerance.22424821
Ischemia, Atrial Fibrillation by ECG Finding, Dyslipidemias, Edema, Heart failure, Ischemic stroke, Hemiplegia, Atrial Fibrillation, Chronic Kidney DiseasesDeregulated Nutrient SensingIn the multivariate analysis, variables related to mortality in acute ischemic stroke were age, chronic renal failure, dyslipidemia, history of heart failure, atrial fibrillation (AF), presenting as hemiplegia, signs of acute ischemia and perilesional edema in the brain scan on hospital admission.22425144
Sensorineural Hearing Loss (disorder), Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOf the three lifestyle-related diseases hypertension, dyslipidemia, and diabetes, only diabetes was significantly associated with SSNHL risk.22426290
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGenetic variability of the major subunit (CACNA1E) of the voltage-dependent Ca(2+) channel Ca(V)2.3 is associated to risk of type 2 diabetes, insulin resistance and impaired insulin secretion in nondiabetic subjects.22427875
Cessation of lifeDeregulated Nutrient SensingInsulin resistance measured as ISI or fasting insulin concentration is associated with increased risk of death among older adults, adjusting for conventional confounding characteristics.22432118
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingStatistically significant lower SctO(2) values were observed in patients with diabetes (P=.026; confidence interval [CI], 0.006-0.090) and in patients with dyslipidemia (P=.007; CI, 0.018-0.103).22432554
Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOf these patients, 76% had preoperative co-morbidities, including insulin resistance in 59.2%, dyslipidemia in 23.5%, hepatic steatosis in 16%, and type 2 diabetes mellitus in 3.9%.22433934
Depressed moodDeregulated Nutrient SensingA neural circuitry linking insulin resistance to depressed mood.22434915
Depressed mood, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) confers risk for Type 2 diabetes and is associated with depressed mood.22434915
Dyslipidemias, Coronary Arteriosclerosis, Obesity, Hypertension, CTCAE, Complications of Diabetes MellitusDeregulated Nutrient SensingGlycemic control, dyslipidemia, hypertension, obesity, diabetic complications and atherosclerotic disease were measured annually.22435936
Dyslipidemias, Diabetes Mellitus, diabetic, Hypertension, CTCAE, Mental deteriorationDeregulated Nutrient SensingThe results suggest that comprehensive management of diabetes, including dyslipidemia and hypertension, might contribute to the prevention of declines in cognitive function in older diabetic patients.22435946
Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingThe most common co-morbid conditions were insulin resistance 55.1%, dyslipidemia 45.5%, arterial hypertension 23.1%, hypothyroidism 15.4% and non-alcoholic fatty liver disease 12%.22438219
NeoplasmsDeregulated Nutrient SensingWhen Sirtuin 1 was less than 1 pg, the majority of the people had various degrees of tumors or other serious diseases.22443029
Acquired Immunodeficiency SyndromeDeregulated Nutrient SensingWhen Sirtuin 1 levels were less than 0.25 pg BDORT units, a high incidence of AIDS was also detected.22443029
Venous ThromboembolismDeregulated Nutrient SensingInsulin resistance and risk of venous thromboembolism: results of a population-based cohort study.22443091
ObesityDeregulated Nutrient SensingInsulin resistance has a central role in the pathophysiology of the metabolic effects of obesity.22443091
vinyltriethoxysilaneDeregulated Nutrient SensingWe aimed to investigate whether insulin resistance is a risk factor for VTE.22443091
vinyltriethoxysilaneDeregulated Nutrient SensingOur population-based cohort study shows an increased risk of VTE in subjects with increasing insulin resistance but not independently of BMI.22443091
Data types - AddressDeregulated Nutrient SensingAs insulin resistance is reported to be a risk factor for sporadic AD, this PS1-mediated regulatory mechanism of brain insulin signaling may be causally associated with AD pathology.22443192
Hepatobiliary DisorderDeregulated Nutrient SensingIn contrast, nuclear vacuolation was present in all patients with liver disease, ranging from 0.1% to 11.7% hepatocytes, irrespective of the aetiology of liver disease and independent of insulin resistance.22447919
Injury of liverDeregulated Nutrient SensingNuclear vacuolation in hepatocytes is a marker of senescence and likely to be a consequence of liver injury, unrelated to insulin resistance.22447919
square decimeterDeregulated Nutrient SensingIn patients with DM2, pancragen significantly decreased glucose level on an empty stomach and in standard glucose tolerance test and reduced plasma concentrations of insulin and insulin resistance index.22448364
HypoxiaDeregulated Nutrient SensingIn this study, we provide new evidence indicating that overexpression of SirT1 in hepatoma HepG2 cells allowed the cells to become much more resistant to irradiation under hypoxia than under normoxia.22448750
HypoxiaDeregulated Nutrient SensingWhen SirT1 was knocked down in both HepG2 and SK-Hep-1 cells, the radiosensitivity was increased, especially under hypoxia.22448750
Radiation DamageDeregulated Nutrient SensingSirT1 could serve as a novel target of radiation damage and thus as a potential strategy to advance the efficiency of radiotherapy in hepatoma entities.22448750
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient Sensingto compare the effectiveness of metformin and pioglitazone in ameliorating insulin resistance and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS).22451180
Primary malignant neoplasm, Dyslipidemias, No metabolic abnormalities, ObesityDeregulated Nutrient SensingVascular health in cancer survivors may be further compromised by metabolic abnormalities such as obesity, insulin resistance, and dyslipidemias which have also been reported following cancer therapy.22456863
Obesity, AbdominalDeregulated Nutrient SensingThe results of our study indicate that increased Hcy levels are related mostly with abdominal obesity and with insulin resistance.22460264
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia is a cardiometabolic risk factor for the development of type 2 diabetes mellitus.22462348
Polycystic Ovary SyndromeDeregulated Nutrient SensingVitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency.22464806
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingInsulin resistance is one of the most common features of polycystic ovary syndrome (PCOS).22464806
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingSome studies suggest that vitamin D deficiency may have a role in insulin resistance; thus, the aim of the current study was to determine the effect of vitamin D supplementation on insulin resistance in women with PCOS and a vitamin D deficiency.22464806
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingWe hypothesized that vitamin D supplementation would lower the glucose level and insulin resistance in women with PCOS and a vitamin D deficiency.22464806
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingWe were not able to demonstrate the effect of vitamin D supplementation on insulin sensitivity and insulin resistance in women with PCOS and vitamin D deficiency.22464806
GDC AJCC Clinical Stage Terminology, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMultiple logistic analysis showed that the largest risk factor for developing ACS was given by smoking habit, diabetes, hypertension, dyslipidemia, and the TGF-b1 29 TT genotype.22465044
Carcinogenic Chlorinated Hydrocarbon, Lesion of liver, Hepatitis C, Liver CirrhosisDeregulated Nutrient SensingThe results showed that various types of chronic viral hepatitis C and stages of cirrhosis set to increase HOMA-IR versus the controls., which were the most prominent in cases of severe hepatic lesion, which indicates that insulin resistance is a frequent companion of CHC.22466538
Kidney CalculiDeregulated Nutrient SensingAssociations of insulin resistance and glycemic control with the risk of kidney stones.22466823
Kidney CalculiDeregulated Nutrient SensingThe associations of insulin resistance and glycemic control with the risk of kidney stones were explored.22466823
Kidney CalculiDeregulated Nutrient SensingThe significant associations between glycemic control measures and the risk of kidney stones were preserved even after the adjustment for factors related to insulin resistance.22466823
Neoplasm Metastasis, Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingSRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice.22470132
Cardiovascular Physiological Phenomena, Diabetes Mellitus, Disease, Nerve DegenerationDeregulated Nutrient SensingSIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration.22470132
NeoplasmsDeregulated Nutrient SensingHowever, accumulating evidence shows that SIRT1 is overexpressed in various types of malignant cells, and its inhibitors suppress the growth of tumor cells.22470132
Neoplasm MetastasisDeregulated Nutrient SensingThe relationship between SIRT1 and metastasis remains to be clarified.22470132
Neoplasm Metastasis, Breast CarcinomaDeregulated Nutrient SensingHere, we examined the effect of SRT1720, a SIRT1 activator, on lung metastasis of breast cancer cells.22470132
Secondary malignant neoplasm of lung, Neoplasm Metastasis, Breast CarcinomaDeregulated Nutrient SensingThese findings imply that SRT1720 promotes the pulmonary metastasis of breast cancer cells and SIRT1 may be an important target for suppressing metastasis to the lung.22470132
Hypertension, CTCAE, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingPreviously she had been treated for hypothyroidism, hypertension, and dyslipidemia.22471430
DyslipidemiasDeregulated Nutrient SensingHowever, dyslipidemia frequency showed a complex pattern of an initial decline and then an increase.22474244
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingEven though the practice guideline has been launched since 2008, diabetes, hypertension and dyslipidemia were still poorly controlled.22475634
Dyslipidemias, GDC AJCC Clinical Stage Terminology, Diabetes MellitusDeregulated Nutrient SensingSubjects without dyslipidemia and intron 4 a/b genotype present a lower chance for ACS development, whereas subjects without diabetes and 894TT genotype show a higher risk for ACS (OR 1.7; 95% CI 1.2-2.3).22475779
Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingIn patients without dyslipidemia, the 894GG genotype presented a tendency to behave as a protector factor against ACS.22475779
Data types - Address, Diabetes MellitusDeregulated Nutrient SensingAlthough a connection between AD and diabetes has been suggested, a major unknown is the mechanism(s) by which insulin resistance in the brain arises in individuals with AD.22476196
Alzheimers Disease", Impaired cognitionDeregulated Nutrient SensingDemonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.22476197
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingWhile a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder.22476197
Data types - Address, Diabetes MellitusDeregulated Nutrient SensingIn the HF, these candidate biomarkers of brain insulin resistance increased commonly and progressively from normal cases to mild cognitively impaired cases to AD cases regardless of diabetes or APOE e4 status.22476197
Impaired cognition, Data types - Address, physiopathologicalDeregulated Nutrient SensingBrain insulin resistance thus appears to be an early and common feature of AD, a phenomenon accompanied by IGF-1 resistance and closely associated with IRS-1 dysfunction potentially triggered by Ab oligomers and yet promoting cognitive decline independent of classic AD pathology.22476197
Sleep Apnea, Obstructive, ObesityDeregulated Nutrient SensingRisk for obstructive sleep apnea in obese, nondiabetic adults varies with insulin resistance status.22481243
Osage languageDeregulated Nutrient SensingSurrogate estimates of insulin resistance based on fasting insulin, triglycerides, and/or HDL-C can be used to help identify those obese adults who would benefit most from OSA screening and referral for polysomnography.22481243
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn this sample, 11/30 (36.67%) had high blood pressure, 5/30 (16.67%) had diabetes mellitus, 6/30 (20%) had dyslipidemia and 2/30 (6.67%) were smokers.22481700
DyslipidemiasDeregulated Nutrient SensingFrequency of dyslipidemia increased up to 65 years, except for low high-density lipoprotein cholesterol which did not vary with age.22483404
Thrombosis, AtherosclerosisDeregulated Nutrient SensingAdipose tissue may release mediators that induce a chronic inflammatory state and alterations in coagulation, which contribute to insulin resistance, atherosclerosis, and thrombosis.22484367
ObesityDeregulated Nutrient SensingThese are labelled obesity, lipids, insulin resistance and blood pressure.22485169
ObesityDeregulated Nutrient SensingThe exploratory factor analysis with oblique rotation suggested an overlap of the loadings identified on the insulin resistance and obesity factors.22485169
Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe main study found that, compared with usual care, addition of a pharmacist resulted in improvements in blood pressure, dyslipidaemia, and hyperglycaemia for primary care patients with Type 2 diabetes.22486226
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingWe aimed to characterize the association of insulin resistance, impaired insulin secretion and b-cell dysfunction in relation to HbA(1c) levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes.22486679
Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient Sensing[Association between serum adipocyte fatty acid binding protein level and dyslipidemia in patients with obstructive sleep apnea syndrome].22490689
Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient SensingTo explore the association between serum adipocyte fatty acid binding protein (A-FABP) levels and dyslipidemia in patients with obstructive sleep apnea syndromes (OSAS).22490689
Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and elevated level of serum A-FABP are common in OSAS patients.22490689
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe independent risk factors of T2DM was dyslipidemia (HR = 1.459; 95%CI: 1.027 - 2.072, P < 0.05) and hypertension (HR = 1.516; 95%CI: 1.039 - 2.212, P < 0.05) based upon the COX's proportional hazard analysis.22490691
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia (HR = 1.545; 95%CI: 1.087 - 2.195, P < 0.05) and hypertension (HR = 1.524; 95%CI: 1.044 - 2.224, P < 0.05) were also independent risk factors of abnormal glycometabolism (T2DM and IGR).22490691
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAccording to multivariate analysis, hypertension and dyslipidemia are independent risk factors of T2DM and abnormal glycometabolism (T2DM and IGR).22490691
DyslipidemiasDeregulated Nutrient SensinghsCRP increased in proportion with the degree of dyslipidemia.22490712
TG gene, DyslipidemiasDeregulated Nutrient SensingA weak positive correlation between TG and hsCRP as well as a weak negative correlation between HDL-C and hsCRP was evidenced in the whole cohort suggesting dyslipidemia might be related to enhanced inflammatory status.22490712
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingPerformance of a multi-marker diabetes risk score in the Insulin Resistance Atherosclerosis Study (IRAS), a multi-ethnic US cohort.22492485
Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingThis study compares a previously developed Diabetes Risk Score to commonly used clinical tools for type 2 diabetes risk evaluation in the Insulin Resistance Atherosclerosis Study (IRAS) cohort, a multi-ethnic US cohort.22492485
Hypertension, CTCAE, Liver CirrhosisDeregulated Nutrient SensingInsulin resistance in patients with cirrhosis and portal hypertension.22492691
Endothelial dysfunction, Liver CirrhosisDeregulated Nutrient SensingInsulin resistance (IR) is involved in the pathogenesis of endothelial dysfunction and is also present in patients with cirrhosis.22492691
ObesityDeregulated Nutrient SensingRodent data show that altered hypothalamic signaling contributes to the development of obesity and insulin resistance.22492775
ObesityDeregulated Nutrient SensingIncreased adipose tissue lipolytic activity is considered an important factor in the pathogenesis of skeletal muscle insulin resistance associated with obesity.22492868
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingT2D is primarily characterized by insulin resistance, and growing evidence has indicated the causative link between adipose tissue inflammation and the development of insulin resistance.22499789
Inflammation, diabeticDeregulated Nutrient SensingWe found CD44 deficiency in a diabetic mouse model ameliorates insulin resistance and adipose tissue inflammation and also found that anti-CD44 antibody treatment decreases blood glucose levels and adipose tissue macrophage accumulation in a high-fat, diet-fed mouse model.22499789
Sleep-Disordered Breathing, Diabetes MellitusDeregulated Nutrient SensingSDB is independently related to the development of insulin resistance and, thereby, the risk of manifest diabetes mellitus.22499826
Best Case Imputation Technique, Dyslipidemias, diabetic, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingThe studied sample had a subset of high-risk of BC featured by postmenopausal overweight and diabetic women, who also had a personal history of hypertension and/or dyslipidemia.22502657
GDC Disease Response Terminology, Dyslipidemias, Coronary Artery Disease, Cerebrovascular accidentDeregulated Nutrient SensingIn comparison to no-DR, DR patients were older and more likely to have high prevalence of dyslipidemia, coronary artery disease and cerebrovascular accidents.22502915
Ventricular hypertrophyDeregulated Nutrient SensingThe relationship of visfatin levels with insulin resistance and left ventricular hypertrophy in peritoneal dialysis patients.22503095
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingFactors significantly and independently associated to CKD were older age, hypertension and dyslipidemias.22503754
DysglycemiaDeregulated Nutrient SensingHigh incidence of insulin resistance and dysglycemia amongst nondiabetic cardiac surgical patients.22503851
DysglycemiaDeregulated Nutrient SensingPreoperative insulin resistance, not FBG, is significantly associated with the development of perioperative dysglycemia.22503851
DysglycemiaDeregulated Nutrient SensingInsulin resistance screening may be useful to identify insulin resistance preoperatively and predict the degree of perioperative dysglycemia in cardiac surgical patients but should be performed with a more appropriate and reproducible test.22503851
Rheumatoid Arthritis, Dyslipidemias, NecrosisDeregulated Nutrient SensingDyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti-tumor necrosis factor therapy.22504829
Refractory anemias, Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingTo investigate the frequency of lipid testing in clinical practice and to explore the relationship between rheumatoid arthritis (RA), dyslipidemia, and other cardiovascular (CV) risk factors with RA treatment.22504829
Inflammation, ObesityDeregulated Nutrient SensingIn obesity, adipose tissue becomes a significant source of chemokines and inflammatory cytokines that are associated with chronic systemic low-grade inflammation and may lead to insulin resistance.22508338
Inflammation, Obesity, Diabetes MellitusDeregulated Nutrient SensingChronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes.22509446
Inflammation, Obesity, Diabetes MellitusDeregulated Nutrient SensingBased on our recent findings on persistent organic pollutants (POPs) including the lack of an association between obesity and either insulin resistance or diabetes prevalence among subjects with very low concentrations of POPs, we hypothesized that POP concentrations may be associated with inflammation and modify the associations between inflammation and insulin resistance in non-diabetic subjects.22509446
InflammationDeregulated Nutrient SensingIn the current study, OC pesticides were associated with increased levels of CRP, a marker of inflammation, and both OC pesticides and PCBs may also modify the associations between CRP and insulin resistance.22509446
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn view of recent guidelines for the clinical management of dyslipidemia recommending the monitoring of non-HDL cholesterol as a secondary target after achieving the low-density lipoprotein (LDL) cholesterol goal, we aimed to assess the association of non-HDL cholesterol with incident type 2 diabetes and compare its utility as a risk predictor with traditional lipid variables in Aboriginal Canadians.22510237
Hypertensive disease, Increased insulin level, Hypertension, CTCAEDeregulated Nutrient SensingAlthough hyperinsulinemia, a surrogate of insulin resistance, may play a role in the pathogenesis of hypertension (HTN), the longitudinal association between fasting insulin level and HTN development is still controversial.22511258
Adrenal Gland Neoplasms, Cardio-Renal Syndrome, Eyelid Xanthoma, Dyslipidemias, Delusions, CTCAEDeregulated Nutrient SensingAdditional examinations and consultations demonstrated dyslipidemia, xanthelasma, incomplete block of the right branch of His bundle, thyreocardiac syndrome, benign adrenal tumor, and delusions.22515675
Dyslipidemias, Ulcer, Diabetes Mellitus, Retinal Diseases, Cerebrovascular Disorders, Diabetic peripheral neuropathy, Hypertension, CTCAEDeregulated Nutrient SensingMultivariate analysis revealed that age, female sex, diabetes duration, lower glycated haemoglobin, treatment with oral hypoglycaemic agents or insulin, presence of retinopathy, history of cerebrovascular or peripheral arterial disease, presence of hypertension or dyslipidaemia, and history of foot ulcer were independently associated with diabetic peripheral neuropathy.22519862
Hyperglycemia, Dyslipidemias, Anemia, Hypoalbuminemia, Kidney FailureDeregulated Nutrient SensingMen had higher scores both for BI (70 -SD 34.4- vs. 50.4 -SD 36.6-, P = .005) and CME (16.5 -SD 9.1- vs. 9.1 -SD 11.6-, P = .008); 40.3% of the centenarians had anaemia, 67.5% renal failure, 13% hyperglycaemia, 22.1% hypoalbuminaemia and 10.7% dyslipidaemia, without statistically significant differences regarding sex.22520618
Hepatitis C, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBeneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: implications for type 2 diabetes.22520843
Hepatitis CDeregulated Nutrient SensingIndividuals with a definitive diagnosis of chronic hepatitis C and insulin resistance were eligible for participation.22520843
Hepatitis C, ChronicDeregulated Nutrient SensingBCAA therapy did not have adverse effects on glucose tolerance or insulin sensitivity in patients with chronic hepatitis C and insulin resistance.22520843
Cell secretion, Diabetes MellitusDeregulated Nutrient SensingA parental history for diabetes markedly affects residual insulin secretion and secretory loss rate in T2DM offspring without worsening insulin resistance.22521319
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe prevalence was high in participants with dyslipidemia (70.4%), hypertension (56.8%), and obesity (53%).22521729
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingGlucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk.22522760
Glucose Intolerance (disease)Deregulated Nutrient SensingThis finding suggests that the dissociation of free cholesterol from lipoprotein particles occurs in normolipidemic glucose intolerance and may participate in atherogenic signaling.22522760
Triglycerides to HDL Cholesterol Ratio Measurement, IFNG wt Allele, Diabetes MellitusDeregulated Nutrient SensingAmong subjects without diabetes or IFG, a third showed a high triglycerides/HDL-cholesterol ratio, indicating insulin resistance.22523842
Obesity, Abdominal, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingWe conclude that the Canarian-Venezuelan community suffers high prevalence of cardiovascular risk factors (obesity, abdominal obesity, dyslipidemia, diabetes).22523842
Reduced Device Function, Microalbuminuria, Dyslipidemias, Diabetes Mellitus, Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingThey also had more frequently diabetes, dyslipidemia, reduced renal function, microalbuminuria, left-ventricular hypertrophy and previous history of cardiovascular events.22525201
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingPrevalence of type 2 diabetes mellitus (T2DM), hypertension and dyslipidemia were recorded.22527598
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingDyslipidemia was seen in 7.3 % of hyperuricemic patients as compared to 5.8 % of the normouricemic subjects.22527598
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingThere was no significant correlation between the occurrence of T2DM and dyslipidemia and hyperuricemia.22527598
Thrombophilia, Cardiovascular Diseases, Atherosclerosis, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability.22527619
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGenetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis.22527884
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results indicated that genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin resistance in Chinese.22527884
Sleep Apnea, ObstructiveDeregulated Nutrient SensingInsulin resistance and adipose-derived hormones in young men with untreated obstructive sleep apnea.22528956
Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingObstructive sleep apnea (OSA) increases the risk for insulin resistance (IR).22528956
Dyslipidemias, Failure (biologic function)Deregulated Nutrient SensingThe failure of therapy with oral hypoglycemic drugs leads to not only poorly regulated glycemic status, but also dyslipidemia and increased body weight and body mass index (BMI).22533711
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingMetabolic risk factors (obesity, arterial hypertension, dyslipidemia) were highly prevalent in the study patients, and these factors were more prevalent among women.22534719
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity, hypertension, and dyslipidemia were more prevalent among women.22534719
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingRisk factor control in German patients was inadequate (control rates: hypertension 36.3%, dyslipidemia 30.4%, type 2 diabetes 40.6%, obesity 28.8%) but largely comparable to other ROE countries; however, physicians tended to overestimate control rates.22536072
ObesityDeregulated Nutrient SensingAmong the subjects studied, circulating chemerin levels were associated with obesity markers but not with markers of insulin resistance.22544171
Ischemia, HypertrophyDeregulated Nutrient SensingIn the heart, intrinsic activation of the AMP-dependent protein kinase (AMPK) plays a pivotal role in the stress response to ischemia and hypertrophy.22546364
ObesityDeregulated Nutrient SensingThe purpose of the present study was to investigate the influence of obesity and aging on the AMPK signaling pathway in human cardiac tissue.22546364
Refractory anemiasDeregulated Nutrient SensingRight atrial tissue (RA) was analyzed for the expression of the AMPK upstream kinases CAMKK and LKB1, activation of AMPK as well as phosphorylation of the AMPK downstream targets ACC, eEF2, mTOR and eNOS.22546364
Refractory anemias, ObesityDeregulated Nutrient SensingDespite the low total serum adiponectin and HMW adiponectin, AMPK activation was high in the RA of obese patients (YO, OO).22546364
ObesityDeregulated Nutrient SensingThese data indicate that obesity and aging result in significant changes although many direct parameters in the AMPK signaling pathway are not changed in the same direction.22546364
Pulmonary EmphysemaDeregulated Nutrient SensingSIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.22546858
ARCN1 geneDeregulated Nutrient SensingAnti-aging sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deacetylase, is reduced in lungs of patients with COPD.22546858
Hypertrophy, Impaired lung functionDeregulated Nutrient SensingAblation of Sirt1 in airway epithelium, but not in myeloid cells, aggravated airspace enlargement, impaired lung function, and reduced exercise tolerance.22546858
Inflammation, Pulmonary EmphysemaDeregulated Nutrient SensingThus, SIRT1 protects against emphysema through FOXO3-mediated reduction of cellular senescence, independently of inflammation.22546858
Inflammation, Diabetes MellitusDeregulated Nutrient SensingChronic low-grade inflammation is crucial for the development of insulin resistance and type 2 diabetes mellitus (T2DM), and immunocompetent cells, such as T-cells, B-cells, mast cells and macrophages, regulate the pathogenesis of T2DM.22547395
ObesityDeregulated Nutrient SensingBariatric surgery is an additional option in the treatment of obesity and insulin resistance.22549255
InflammationDeregulated Nutrient SensingChanges in biomarkers linked to insulin resistance and inflammation were not observed.22549511
Liver carcinomaDeregulated Nutrient SensingSIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.22552445
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingOverexpression of SIRT1 in cancer tissue, compared with normal tissue, has been demonstrated, suggesting that SIRT1 may act as a tumor promoter.22552445
Primary malignant neoplasmDeregulated Nutrient SensingThe function of SIRT1 in liver cancer has not been elucidated.22552445
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingThe results demonstrate that SIRT1 promotes tumorigenesis of hepatocellular carcinoma (HCC) through the PTEN/PI3K/AKT signaling pathway.22552445
Primary malignant neoplasmDeregulated Nutrient SensingSIRT1 may serve as a novel target for selective killing of cancer versus normal liver cells.22552445
Carcinogenesis, Pancreatic carcinomaDeregulated Nutrient SensingHypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer.22552606
Adenocarcinoma of pancreasDeregulated Nutrient SensingMethylation of HIC1 promoter HIC1 and SIRT1 expression were detected in human normal pancreas (NP), CP and pancreatic adenocarcinoma tissues.22552606
CarcinogenesisDeregulated Nutrient SensingOur results indicate that hypermethylation of HIC1 promoter in CP may contribute to the aberrant expression of HIC1/SIRT1 pathway and then involve in the pancreatic carcinogenesis.22552606
Diabetes MellitusDeregulated Nutrient SensingElevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes.22552911
Beta-cell dysfunction, Diabetes MellitusDeregulated Nutrient SensingThe purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes.22552911
Blood GlucoseDeregulated Nutrient SensingIn conclusion, the levels of branched-chain, aromatic amino acids and alanine increased and the levels of glutamine and histidine decreased with increasing glycemia, reflecting, at least in part, insulin resistance.22553379
Colorectal CarcinomaDeregulated Nutrient SensingColorectal cancer (CRC) is associated with lifestyle factors that affect insulin/IGF signaling, of which the insulin receptor substrate 1 (IRS1) is a key transducer.22558377
NeoplasmsDeregulated Nutrient SensingNutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth.22560924
nervous system disorder, Cachexia, ObesityDeregulated Nutrient SensingThis assay will be valuable for investigating neurological and cardiac diseases and states of cachexia, insulin resistance, and obesity.22561185
Glioblastoma Multiforme PathwayDeregulated Nutrient SensingNotably, suppression of RGS4-dependent glioma cell invasion was signaled through both mTOR complexes, mTORC1 and mTORC2, in a concentration-dependent manner, indicating that high doses of CCI-779 may overcome tumor-cell resistance associated with the sole inhibition of mTORC1.22562250
Myocardial Ischemia, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThese data add evidence to support a causal link between increased BMI and IHD risk, though the mechanism may ultimately be through intermediate factors like hypertension, dyslipidemia, and type 2 diabetes.22563304
InflammationDeregulated Nutrient SensingRelationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study.22563924
Inflammation, Sarcopenia, ObesityDeregulated Nutrient SensingIt has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia.22563924
InflammationDeregulated Nutrient SensingInsulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population.22563924
DyslipidemiasDeregulated Nutrient SensingAt least one dyslipidemia was present in 50.8% of all patients and in 71.1% of high-risk patients.22566746
DyslipidemiasDeregulated Nutrient SensingAmong all subjects with any dyslipidemia, 30.9% had mixed dyslipidemias and 69.4% had low HDL-C and/or elevated triglycerides, while 30.6% had isolated elevated LDL-C; corresponding values for high-risk patients were 36.8%, 58.9%, and 41.1%.22566746
DyslipidemiasDeregulated Nutrient SensingMixed dyslipidemias in primary care patients in France.22566746
DyslipidemiasDeregulated Nutrient SensingOral carnitine supplementation for dyslipidemia in chronic hemodialysis patients.22569432
DyslipidemiasDeregulated Nutrient SensingCarnitine deficiency is a commonly observed problem in maintenance hemodialysis (MHD) patients, which results in altered metabolism of fatty acids and subsequently development of dyslipidemia.22569432
Hyperthyroidism, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingCarvedilol might be a preferred agent to treat hyperthyroid patients who have hypertension and dyslipidemia.22571552
Endothelial dysfunctionDeregulated Nutrient SensingThis is likely due to insulin resistance of protein metabolism and/or endothelial dysfunction with a reduction in nutritive flow, both of which can be improved by aerobic exercise.22572647
ObesityDeregulated Nutrient SensingAssociation of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults.22573135
ObesityDeregulated Nutrient SensingThe aim of this study was to determine whether low levels of OCN would be associated with insulin resistance, obesity, and greater cardiovascular (CV) risk in young adults just emerging from adolescence.22573135
ObesityDeregulated Nutrient SensingHowever, the significant associations of OCN with SBP, obesity, and adiponectin and borderline with M(lbm), suggest a potential role for OCN in the development of insulin resistance and CV risk that becomes more apparent with aging into older adulthood.22573135
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was a high prevalence of diabetes, hypertension, dyslipidemia and current smoking.22574544
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingMultivariate statistic analysis supports a relation with older age, female gender, dyslipidemia and heart disease.22575556
Non-alcoholic Fatty Liver Disease, Liver carcinoma, Liver Cirrhosis, ObesityDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance.22576780
Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingSleep duration is associated with dyslipidemia in patients with bipolar disorder in clinical remission.22578889
Inflammation, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAlthough previous studies have suggested associations between plasma palmitoleic acid and coronary heart disease (CHD) risk factors, including blood pressure, inflammation, and insulin resistance, little is known about the relation of palmitoleic acid and CHD.22579341
Dyslipidemias, OverweightDeregulated Nutrient SensingOverweight and dyslipidemia were significantly more frequent in women (P<0.001), while smoking and physical inactivity were significantly more frequent in men (P<0.001).22579490
Dyslipidemias, Overweight, Diabetes MellitusDeregulated Nutrient SensingDuring the period, there was a moderate rise of the prevalence of overweight, dyslipidemia, and physical inactivity, whereas the prevalence of diabetes and smoking remained almost unchanged.22579490
Arterial Stiffness, DyslipidemiasDeregulated Nutrient SensingReduced mortality in patients with sevelamer HCl may, at least in part, be explained by an improvement in dyslipidemia and arterial stiffness by sevelamer HCl.22581064
Acute myocardial infarction, Glucose Intolerance (disease)Deregulated Nutrient SensingRecent studies have demonstrated that newly diagnosed glucose intolerance is common among patients with acute myocardial infarction (AMI).22581733
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingAlthough second-generation antipsychotics were associated with dyslipidemia and insulin resistance, they were not associated with vasculopathy.22584147
Heart failureDeregulated Nutrient SensingVentricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure.22586279
Heart failureDeregulated Nutrient SensingSystemic insulin resistance in heart failure was accompanied by decreased myocardial triglyceride and overall fatty acid content but increased toxic lipid intermediates, diacylglycerol, and ceramide.22586279
Diabetes MellitusDeregulated Nutrient SensingA gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians.22586585
Diabetes MellitusDeregulated Nutrient SensingResults show that although multiple SNPs showed marginal individual association with insulin resistance and type 2 diabetes, only a few can pass adjustment for multiple testing.22586585
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingHowever, a gene-family analysis considering the joint impact of all 61 SNPs reveals significant association of the nAChR gene family with both insulin resistance and type 2 diabetes (both P < 0.0001), suggesting that genetic variants in the nAChR genes jointly contribute to insulin resistance and type 2 diabetes among American Indians.22586585
Addison Disease, Dyslipidemias, ObesityDeregulated Nutrient SensingBClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidaemia in patients with Addison's disease.22587831
Addison Disease, DyslipidemiasDeregulated Nutrient SensingThese results suggest that BclI polymorphism may influence the sensitivity to glucocorticoids in patients with Addison's disease and may contribute, along with other factors, to the increase in central adiposity, impaired glucose metabolism and dyslipidaemia.22587831
melanomaDeregulated Nutrient SensingRaf/MEK/ERK signaling can inhibit the liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway, thus rendering melanoma cells resistant to energy stress conditions.22588166
melanomaDeregulated Nutrient SensingNine melanoma cell lines were treated with the AMPK activators 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) and phenformin.22588166
Schizophrenia, DyslipidemiasDeregulated Nutrient SensingAntipsychotic-treated schizophrenia patients are susceptible to dyslipidemia.22591814
Hypertensive disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThrough Chi-square significant differences (P=0.00001-0.03874) between specific ethnic groups for all four PAD-related risk factors (i.e., HTN, dyslipidemia, diabetes and cigarette smoking).22608174
Hypertensive disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAll of the associations between the prevalence of HTN, dyslipidemia, diabetes, or cigarette smoking and ethnicity were statistically significant (P=<0.0001).22608174
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThey were more likely to be morbidly obese (32% versus 9%), have dyslipidemia (25% versus 6%), or have hypertension (53% versus 38%; P < 0.01).22611040
Hepatitis C, ChronicDeregulated Nutrient SensingInsulin resistance undermines the advantages of IL28B polymorphism in the pegylated interferon alpha-2b and ribavirin treatment of chronic hepatitis C patients with genotype 1.22613000
Communicable Diseases, Hepatitis CDeregulated Nutrient SensingRecent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection.22613000
Parkinson DiseaseDeregulated Nutrient SensingGenetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.22613205
Neurodegenerative Disorders, Primary malignant neoplasm, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, DiseaseDeregulated Nutrient SensingSIRT1 gene has been connected to many cellular processes and implicated in human diseases, such as obesity, type 2 diabetes, cancer and neurodegenerative diseases.22613205
palladiumDeregulated Nutrient SensingStudies in animal model have also associated SIRT1 with aggregation of alpha-synuclein, a critical protein in the PD pathogenesis.22613205
palladiumDeregulated Nutrient SensingWe hypothesized that the genetic variants within the regulatory regions of SIRT1 gene that repress its gene expression, rather than mutations in its coding region that abolish SIRT1 function, may contribute to PD as a risk factor.22613205
palladiumDeregulated Nutrient SensingIn this study, we genetically analyzed the promoter region of SIRT1 gene in sporadic PD patients and ethic-matched healthy controls.22613205
palladiumDeregulated Nutrient SensingThree novel heterozygous sequence variants, g.69644133C>G, g.69644213G>A and g.69644351G>A, were identified in PD patients, but in none of controls, which may alter the transcriptional activities of SIRT1 gene promoter, resulting in reduced SIRT1 levels.22613205
palladiumDeregulated Nutrient SensingTherefore, our results suggested that genetic variants within the SIRT1 gene promoter may repress SIRT1 gene expression, contributing to PD as a risk factor.22613205
CD55 gene, DyslipidemiasDeregulated Nutrient Sensing11.4% of the children had either TC or TG dyslipidemia, with 7.1% had only TC dyslipidemia, 4.9% had only TG dyslipidemia, and 0.6% of them had both TC and TG dyslipidemia.22613377
DyslipidemiasDeregulated Nutrient SensingThe prevalence rates of TC dyslipidemia and TG dyslipidemia were different among age groups, but with no significant changes among age groups.22613377
DyslipidemiasDeregulated Nutrient SensingThe prevalence of TG dyslipidemia was significantly different, with obese children higher than those with normal or overweight children.22613377
DyslipidemiasDeregulated Nutrient SensingPrevalence of TG dyslipidemia was higher in rural than urban areas.22613377
Dyslipidemias, Atherosclerosis, Coronary heart diseaseDeregulated Nutrient SensingScreening and intervention programs on dyslipidemia should be undertaken routinely in children, in order to prevent adult atherosclerosis and coronary heart disease.22613377
Vascular Diseases, Acute myocardial infarctionDeregulated Nutrient SensingRelationship between endothelial nitric oxide synthase, insulin resistance and macrovascular disease in patients with acute myocardial infarction.22613431
Vascular Diseases, Acute myocardial infarctionDeregulated Nutrient SensingTo explore the relationship between endothelial nitric oxide synthase (eNOS) activity, insulin resistance and macrovascular disease in patients with acute myocardial infarction (AMI).22613431
Vascular DiseasesDeregulated Nutrient SensingThere is a close relationship between eNOS activity and the development of insulin resistance and macrovascular disease in AMI patients.22613431
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome XDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome related to insulin resistance.22616493
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe factors associated with impaired access blood flow were old age, diabetes mellitus and dyslipidemia.22619889
HD Term Type, Dyslipidemias, physiopathological, Diabetes MellitusDeregulated Nutrient SensingThis present study suggests that annual direct measurement of access blood flow as ultrasound dilution technique is an acceptable tool to screen AVF dysfunction, especially HD patients of old age, and/or with diabetes mellitus and dyslipidemia.22619889
Dyslipidemias, Carotid Intima-Media ThicknessDeregulated Nutrient SensingStudy design, rationale, and baseline characteristics: evaluation of fenofibric acid on carotid intima-media thickness in patients with type IIb dyslipidemia with residual risk in addition to atorvastatin therapy (FIRST) trial.22622962
DyslipidemiasDeregulated Nutrient SensingThese data suggest that the use of OCs may reduce the risk of dyslipidemia, mainly due to the decreased risk of low HDL-C, in Korean women.22625865
vascular inflammations, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin and leptin are important markers of insulin resistance and vascular inflammation in metabolic and cardiovascular diseases.22633795
Hashimoto Disease, Inflammation, HaitiDeregulated Nutrient SensingThe relationship between inflammation, Hashimoto's thyroiditis (HT) and insulin resistance is still controversial.22639339
HaitiDeregulated Nutrient SensingThese results suggest that HT patients with high RBP4 and A-FABP levels might deserve a particular attention, being potentially more exposed to develop insulin resistance and increased cardiovascular risk.22639339
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingThe mammalian target of rapamycin complex 1 (mTORC1) is aberrantly activated in many head and neck squamous cell carcinomas (HNSCCs).22644799
Microalbuminuria, Hypertension, CTCAE, Retinal Diseases, DyslipidemiasDeregulated Nutrient SensingObese patients more often had elevated HbA1c (>=7.5%), hypertension or dyslipidemia (irrespective of age), microalbuminuria (adults), or retinopathy (elderly) than nonobese patients.22645200
Precocious pubarcheDeregulated Nutrient SensingIGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance.22646060
MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE, Precocious pubarcheDeregulated Nutrient SensingWe have previously reported that severe pre- and post-natal growth restriction associated with insulin resistance and precocious pubarche in a woman without body asymmetry or other SRS features resulted from a balanced translocation affecting the regulation of her IGF2 gene expression.22646060
MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE, Precocious pubarcheDeregulated Nutrient SensingWe hypothesised that severe pre- and post-natal growth restriction associated with insulin resistance and precocious pubarche in the absence of SRS are also caused by downregulation of IGF2 through hypomethylation, gene mutation or structural chromosomal abnormalities.22646060
MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE, Precocious pubarcheDeregulated Nutrient SensingOur case of growth restriction, premature pubarche and insulin resistance in the absence of body asymmetry or other features of SRS adds to the expanding phenotype of IGF2/H19 methylation abnormalities.22646060
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThere were differences among Italian macro-areas mainly for obesity, hypertension, dyslipidaemia and diabetes.22647342
Cachexia, Generalized amyotrophyDeregulated Nutrient SensingInsulin resistance of protein anabolism has been speculated to underlie the skeletal muscle wasting characteristic of cancer cachexia.22647419
Increased insulin level, Carcinoma of lungDeregulated Nutrient SensingWe tested whether insulin resistance is present in cachectic lung cancer patients and if a sustained, physiological elevation of amino acids with hyperinsulinemia would compensate for it.22647419
Non-Small Cell Lung Carcinoma, CachexiaDeregulated Nutrient SensingNSCLC patients with moderate cachexia showed considerable insulin resistance of glucose and of whole-body protein anabolism.22647419
Malignant neoplasm of gastrointestinal tract, Diabetes MellitusDeregulated Nutrient SensingFor patients with gastrointestinal cancer complicated with diabetes mellitus, microbiota enteral nutrition can reduce insulin resistance, improve the immune status, and promote postoperative recovery.22648843
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWhen compared with non-tobacco and ex-tobacco users, overall current tobacco users were younger, more likely to be male subjects and less likely to have diabetes mellitus, hypertension and dyslipidaemia.22652700
Coronary ArteriosclerosisDeregulated Nutrient SensingAlanine aminotransferase (ALT) and g-glutamyltransferase (GGT) are associated with insulin resistance and arteriosclerotic disease.22653114
Acute Coronary SyndromeDeregulated Nutrient SensingAdipokines, ghrelin and obesity-associated insulin resistance in nondiabetic patients with acute coronary syndrome.22653312
Obesity, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingIn conclusion, in ACS patients, obesity and obesity-related changes in plasma leptin and adiponectin are associated with and likely contribute to negatively modulate insulin resistance.22653312
Cessation of life, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe risk factors underlying the cause of death are associated with hypertension, obesity and dyslipidemia.22655455
Dyslipidemias, Chest PainDeregulated Nutrient SensingMyocardial bridging assessed by multidetector computed tomography: likely cause of chest pain in younger patients with low prevalence of dyslipidemia.22658689
Lipemia - observation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient Sensingo-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity.22661243
Triple-Negative Breast Cancer Finding, Neoplasm Metastasis, Breast CarcinomaDeregulated Nutrient SensingExpression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer.22661383
Triple-Negative Breast Cancer FindingDeregulated Nutrient SensingThe definite role of SIRT1 is not clear now, and few studies have documented the value of SIRT1 in triple-negative breast cancer (TNBC).22661383
Breast CarcinomaDeregulated Nutrient SensingSIRT1+ group was associated with shorter DFS and OS compared with SIRT1- group in TNBC, non-TNBC, and overall breast cancer patients, according to univariate Cox regression analysis.22661383
Breast CarcinomaDeregulated Nutrient SensingOur study provides evidence that expression of SIRT is associated with worse prognosis in TNBC and non-TNBC and SIRT1 could be a potential therapeutic target in breast cancer.22661383
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingPatterns and determinants of dyslipidaemia in 'Young' versus 'Not so Young' patients of coronary artery disease: a multicentric, randomised observational study in northern India.22664802
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG.22664802
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG.22664802
Diabetes MellitusDeregulated Nutrient SensingAlmost 83% of doctors were aware that Indians have a genetic predisposition to diabetes due to an inherently smaller beta cell mass associated with insulin resistance.22666947
Non-alcoholic Fatty Liver Disease, ETV3 wt AlleleDeregulated Nutrient SensingThe MetS is associated with NAFLD, with the WHO definition being the best to determine its presence, probably because of the inclusion of insulin resistance as a main component.22668875
Osage language, Seizures, Hyperglycemia, Dyslipidemias, ObesityDeregulated Nutrient SensingIndividuals with SZ also had significantly more severe atherogenic profiles (obesity, dyslipidemia, hyperglycemia) than OSA patients (P <= .05).22669072
Dyslipidemias, Chronic disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity is closely associated with chronic diseases such as hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia.22672914
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingBMI was strongly associated with hypertension, while WC was strongly associated with T2DM and dyslipidemia.22672914
Kidney Failure, ChronicDeregulated Nutrient SensingHowever, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown.22673293
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim was to investigate new markers for type 2 diabetes (T2DM) dyslipidemia related with LDL and HDL metabolism.22676273
Non-alcoholic Fatty Liver Disease, AtherosclerosisDeregulated Nutrient SensingInsulin resistance (IR) is the major driving force behind development and progression of atherosclerosis in patients with nonalcoholic fatty liver disease (NAFLD).22676459
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingModifiable cardiovascular risk factors also hypertension were dominated by dyslipidemia (29.8%) and diabetes (24.6%).22677180
AtherosclerosisDeregulated Nutrient SensingChronic HCV infection was associated with severe insulin resistance and mild atherosclerosis: a population-based study in an HCV hyperendemic area.22678465
Hepatitis C, AtherosclerosisDeregulated Nutrient SensingHepatitis C virus (HCV) affects glucose and lipid metabolism in vitro; however, it is unclear whether HCV infection is associated with insulin resistance and atherosclerosis at the population level.22678465
Hepatitis C, AtherosclerosisDeregulated Nutrient SensingThis population-based study in an HCV hyperendemic area revealed that chronic HCV infection was associated with severe insulin resistance and with mild atherosclerosis, suggesting a unique characteristic of HCV-related metabolic abnormality.22678465
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingPitavastatin shows greater lipid-lowering efficacy over 12 weeks than pravastatin in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia.22679249
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingPath analysis revealed that age, sex, perceived social support, history of angina, and dyslipidaemia had both direct effect and indirect effect through psychological distress on the physical health component of HRQoL.22679250
Hyperglycemia, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAdditionally, our study suggested that UA level be an independent risk factor to obesity, hypertension and dyslipidemia, but a protective factor to hyperglycemia.22682157
Metabolic DiseasesDeregulated Nutrient SensingIn line with this premise, decreased activity of PARP-1 or CD38-both NAD(+) consumers-increases NAD(+) bioavailability, resulting in SIRT1 activation and protection against metabolic disease.22682224
No metabolic abnormalitiesDeregulated Nutrient SensingWe show that NR supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.22682224
Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis, Thigh structureDeregulated Nutrient SensingThe association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes.22682537
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingThe relationship between body composition parameters such as thigh and calf circumference and insulin resistance or atherosclerosis in type 2 diabetes is poorly understood.22682537
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingThigh and calf circumference were correlated with insulin resistance and carotid atherosclerosis, and thigh circumference was independently associated with insulin resistance and carotid atherosclerosis in patients with type 2 diabetes.22682537
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMetformin is a drug to improve glycemic control by reducing insulin resistance and is currently considered to be one of the first-choice drugs for type 2 diabetes mellitus (T2DM).22687486
Negative Regulation of Cell Cycle, NCI CTEP SDC Retinoblastoma Sub-Category Terminology, NecrosisDeregulated Nutrient SensingAll these changes were followed by increase in ATP-sensing enzyme AMP-activated protein kinase (AMPK) and declines in cyclin E2 as well as phosphorylated retinoblastoma, resulting in cell-cycle arrest, senescence, and necrosis.22689530
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes was rare but dyslipidemia and family history were frequent in group II.22690091
HypertriglyceridemiaDeregulated Nutrient SensingIn conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.22690097
Rheumatoid Arthritis, NecrosisDeregulated Nutrient SensingAnti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance.22691241
Refractory anemias, Tumor necrosisDeregulated Nutrient SensingTumor necrosis factor (TNF), a pro-inflammatory cytokine with a major pathogenetic role in RA, may promote insulin resistance by inducing Ser312 phosphorylation (p-Ser312) of insulin receptor substrate (IRS)-1 and downregulating phosphorylated (p-)AKT.22691241
Refractory anemiasDeregulated Nutrient SensingWestern blot analysis in seven active RA patients with high insulin resistance showed reduction in p-Ser312 IRS-1 (P = 0.043) and increase in p-AKT (P = 0.001) over the study period.22691241
Refractory anemias, Disease remissionDeregulated Nutrient SensingAnti-TNF therapy improved insulin sensitivity and reversed defects in the insulin signaling cascade in RA patients with active disease and high insulin resistance.22691241
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingOur aim was to investigate the association of serum total testosterone levels with nonalcoholic fatty liver disease (NAFLD), adjusting for the influence of VAT and insulin resistance.22691278
Dyslipidemias, Sedentary, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingConversely, frequencies of hypertension, dyslipidemia, diabetes, obesity, smoking, sedentarism, and hormonal contraception were similar in patients with or without aPL (p >= 0.253).22692396
DyslipidemiasDeregulated Nutrient SensingIt has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects.22695528
Asthma, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension was the most prevalent chronic condition (5.3%), followed by dyslipidemia (4.6%), asthma (0.9%), and diabetes (0.3%).22698173
Hepatobiliary DisorderDeregulated Nutrient SensingBoth SATV and TAT volume (TATV) correlated significantly with severity of liver disease as determined by NAS score whereas presence of MS or insulin resistance had no correlation with histological severity.22700629
Hypertension, CTCAE, Myocardial Ischemia, DyslipidemiasDeregulated Nutrient SensingThe DM group had a higher mean age prevalence of history of hypertension, dyslipidemia, ischemic heart disease, high Killip class, and diagnoses as non-ST elevation MI than the non-DM group.22707890
atherosclerotic, Coronary heart diseaseDeregulated Nutrient SensingInsulin resistance predicts progression of de novo atherosclerotic plaques in patients with coronary heart disease: a one-year follow-up study.22709409
Plaque, AtheroscleroticDeregulated Nutrient SensingInsulin resistance has been generally recognized as a novel risk factor based on epidemiological studies; however, few researches have focused on its effect on coronary atherosclerotic plaque progression.22709409
Plaque, Atherosclerotic, Coronary heart disease, diabeticDeregulated Nutrient SensingInsulin resistance is an independent predictor of atherosclerosis plaque progression in patients with coronary heart disease in both the diabetic and non-diabetic population.22709409
Dyslipidemias, Granuloma AnnulareDeregulated Nutrient SensingDyslipidemia in granuloma annulare: a case-control study.22710282
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is more common in generalized than in localized/disseminated disease, and the annular lesion morphology is associated with hypercholesterolemia and DLP.22710282
Obesity, Abdominal, Overweight, DyslipidemiasDeregulated Nutrient SensingThe most prevalent cardiovascular risk factors were dyslipidemia (34.2%), abdominal obesity (19.7%) and overweight (18.0%).22715112
Dyslipidemias, OverweightDeregulated Nutrient SensingOverweight and obese children were 4.4 times more likely to have dyslipidemia (P < 0.001).22715112
Anxiety, CTCAE 3.0, Dyslipidemias, Depression, CTCAE, ObesityDeregulated Nutrient SensingThe impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression.22717171
Anxiety, CTCAE 3.0, Dyslipidemias, Depression, CTCAE, ObesityDeregulated Nutrient SensingDyslipidemia and obesity have been observed in persons with severe anxiety or depression, and in tricyclic antidepressant (TCA) users.22717171
Inflammation, Dyslipidemias, Depression, CTCAE, Obesity, Anxiety DisordersDeregulated Nutrient SensingIncreased dyslipidemia and (abdominal) obesity risk in patients with more severe anxiety disorders and depression may be partly explained by chronic low-grade inflammation and smoking.22717171
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingVitamin D deficiency is highly prevalent and is associated with dyslipidemia and cardiovascular disease.22718799
HyperglycemiaDeregulated Nutrient SensingDoes insulin resistance drive the association between hyperglycemia and cardiovascular risk?22720085
Communicable Diseases, Fibrosis Assessment, Hepatobiliary Disorder, Hepatitis C, Chronic, Failure (biologic function)Deregulated Nutrient SensingThe interaction between insulin resistance, liver fibrosis and early virological response in Egyptian patients with chronic hepatitis C. Hepatitis C virus (HCV) infection may induce insulin resistance (IR) irrespective of the severity of liver disease, and there is evidence of a central role for IR in failure to achieve sustained virological response (SVR) in HCV patients.22720272
Inflammation, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Vascular DiseasesDeregulated Nutrient SensingNO-deficient states are characterized by cell senescence, oxidative stress, inflammation, endothelial dysfunction, vascular disease, insulin resistance and type 2 diabetes mellitus.22722323
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingHemoglobin A1c showed significant association with abdominal obesity and dyslipidemia and the clustering of cardiometabolic risk factors (odds ratios, 1.58-1.90; all P < 0.05).22722567
Hyperlipidemia, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingBoth waist-to-stature ratio (WSR) (area under the curve 0.75, p=0.002) and waist circumference (WC) (area under the curve 0.77, p=0.001) but not waist-to-hip ratio (WHR) (area under the curve 0.62, p=0.143) were shown to be good markers of increased cardiovascular risk, insulin resistance and dislipidemia in PCOS patients.22727921
Atherosclerotic lesion, AtherosclerosisDeregulated Nutrient SensingAdiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions.22728065
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDevelopment of concomitant fasting glucose intolerance in knock-in mice highlights aberrant B cell selection as a potential risk factor for type 1 diabetes, and suggests altered BCR signalling as a mechanism to cause biased cellular and Ig repertoire selection, ultimately contributing to B cell-mediated autoimmune predisposition.22728826
DyslipidemiasDeregulated Nutrient SensingOne of its principal risk factors is dyslipidemia.22728834
DyslipidemiasDeregulated Nutrient SensingOur data show that dyslipidemia is generally undertreated in high-risk patients, despite the fact that hospitalization brings them in contact with specialized physicians.22728834
Thyroid dysfunction, DyslipidemiasDeregulated Nutrient SensingDyslipidemia in thyroid dysfunction has always been attributed to changes in thyroid hormone (TH) levels.22730515
Lipemia - observation, Obesity, AtherosclerosisDeregulated Nutrient SensingIn addition, elevated postprandial lipemia is an indicator of poor lipid clearance, and it has been associated with atherosclerosis, insulin resistance, and obesity.22738038
Hypertensive (finding), Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingMale sex, advanced age, higher serum triglycerides, and homeostasis model assessment of insulin resistance levels were all significantly associated with the increased risks of pre-diabetes or diabetes in new-onset hypertensive patients when analyzed by the logistic regression analysis.22738422
Inflammation, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingRates of diabetes, dyslipidaemia, hypertension and inflammation are high and increased with age and were associated with urbanization.22738663
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOne fourth had hypertension; 32.1%, dyslipidemia; and 13%, diabetes mellitus.22740730
airway disease, Sleep DisordersDeregulated Nutrient SensingAbdominal adiposity and obstructive airway disease: testing insulin resistance and sleep disordered breathing mechanisms.22742416
Symptoms, Sleep-Disordered BreathingDeregulated Nutrient SensingThis study examined associations of abdominal adiposity with lung function, asthma symptoms and current doctor-diagnosed asthma and mediation by insulin resistance (IR) and sleep disordered breathing (SDB).22742416
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe objective of the study was to evaluate the efficacy and site of action of an insoluble dietary fiber derived from maize (HAM-RS2) in improving insulin resistance in subjects at increased risk of type 2 diabetes mellitus.22745235
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHAM-RS2 improved peripheral but not hepatic insulin resistance and requires further study as an intervention in patients with or at risk for type 2 diabetes.22745235
Virus DiseasesDeregulated Nutrient SensingCytokines are known to play an important role not only in the mechanisms of insulin resistance and glucose disposal defects but also in the pathological processes occurring in the liver during viral infection.22745767
Diabetes MellitusDeregulated Nutrient SensingThis study analyzed the relationships between Lp(a) and both diabetes and insulin resistance in an adult cohort from the island of Gran Canaria, Spain.22748161
Increased insulin level, Angina Pectoris, VariantDeregulated Nutrient SensingEffect of insulin resistance associated with compensatory hyperinsulinemia on the long-term prognosis in patients with vasospastic angina.22748286
Increased insulin level, Angina Pectoris, Variant, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance associated with compensatory hyperinsulinemia plays a significant role in the pathogenesis of cardiovascular diseases, including vasospastic angina (VSA).22748286
Increased insulin levelDeregulated Nutrient SensingHowever, the effects of insulin resistance associated with hyperinsulinemia on the long-term prognosis in patients with VSA remain unclear.22748286
Increased insulin levelDeregulated Nutrient SensingThese data indicate that insulin resistance associated with compensatory hyperinsulinemia increases the risk of cardiac events in VSA patients.22748286
Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Diabetes MellitusDeregulated Nutrient SensingAfter adjusting for age and sex, hypertension, dyslipidemia, and atrial fibrillation were more frequent, and diabetes mellitus was less frequent, among Miami Hispanics compared to Mexicans.22749627
Primary malignant neoplasm, Breast CarcinomaDeregulated Nutrient SensingBased on our results, the downregulation of SIRT1/2 expression may play an important role in the regulation of breast cancer cell death; thus, SIRT1/2 may be a novel molecular target for cancer therapy and these findings may provide a molecular basis for targeting SIRT1/2 in future cancer therapy.22751989
Cardiac dysfunction, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes and insulin resistance are often associated with the co-occurrence of coronary atherosclerosis and cardiac dysfunction.22752026
Ventricular Dysfunction, Ischemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis suggests that insulin resistance, rather than diagnosis of ischaemia or left ventricular dysfunction, affects the metabolism and perfusion features of patients with type 2 diabetes.22752026
Malignant NeoplasmsDeregulated Nutrient SensingPrevious studies have shown a positive relationship between insulin resistance and several common adult cancers.22752254
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance or dysglycaemia was defined using WHO criteria as the presence of diabetes mellitus, impaired fasting glycaemia (IFG) or impaired glucose tolerance (IGT).22752819
Dyslipidemias, Aortic Valve Stenosis, Musculoskeletal PainDeregulated Nutrient SensingHe was initially managed as a case of severe valvular aortic stenosis of rheumatic origin with associated dyslipidaemia and was referred for further evaluation and management abroad.22752829
AtherosclerosisDeregulated Nutrient SensingCDK5-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.22753194
AtherosclerosisDeregulated Nutrient SensingCyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis.22753194
Hypertensive disease, Hyperglycemia, Dyslipidemias, Liver DysfunctionDeregulated Nutrient SensingIn men, HBP (12.9 %), liver dysfunction (33.9 %), dyslipidemia (29.9 %), and hyperglycemia (2.7 %) were observed in the normal BMI group (18.5 < BMI <= 25 kg/m(2)).22760262
Dyslipidemias, Liver Dysfunction, ObesityDeregulated Nutrient SensingAsymptomatic abnormalities, particularly liver dysfunction and dyslipidemia, were observed in a substantial percentage of subjects without obesity.22760262
Dyslipidemias, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingBaseline clinical characteristics were similar except for higher dyslipidemia, systemic hypertension, and family history of coronary artery disease in the EES group.22762711
InflammationDeregulated Nutrient SensingTo investigate the role of low-grade inflammation and insulin resistance (HOMA2-IR) in adiposity-related increases in serum complement factor 3 (C3).22762725
InflammationDeregulated Nutrient SensingSystemic low-grade inflammation and insulin resistance may represent two independent pathways by which body fat leads to elevated C3 levels.22762725
Nausea and vomitingDeregulated Nutrient SensingThe preparation of patients with oral glucose solutions decreases the incidence of postoperative (thyroidectomy) insulin-resistance, and occurrence of nausea/vomiting during the postoperative period.22763301
Refractory anemias, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidaemia were significantly more frequent in both DM groups than RA groups.22764043
Dyslipidemias, Cardiovascular Diseases, Myocardial Ischemia, AtherosclerosisDeregulated Nutrient SensingDyslipidaemia is a major risk factor of cardiovascular diseases, the role of serum total cholesterol (Chol) especially LDL-Chol is well established in the pathogenesis of atherosclerosis and ischemic heart disease.22764575
Refractory anemias, Rheumatoid Arthritis, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR), a risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis (RA).22765047
Endothelial dysfunction, SpondylitisDeregulated Nutrient SensingSince insulin resistance can promote endothelial dysfunction, and anti-TNF-a treatment improves endothelial function in ankylosing spondylitis (AS) patients, in the present study we sought to assess whether an infusion of the anti-TNF-a monoclonal antibody-infliximab may improve insulin sensitivity in non-diabetic AS patients.22765845
Obesity, VisceralDeregulated Nutrient SensingADRB3 Trp64Arg polymorphism, a missense mutation in the first transmembrane domain of the R3-adrenergic receptor is associated with visceral obesity and insulin resistance in the Pima Indian, French, and Finnish populations.22774474
flavin-hypoxanthine dinucleotideDeregulated Nutrient SensingWe investigated the insulin resistance and adiponectin levels of children and adolescents with a family history of T2DM (FHD).22776852
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIS patients showed a higher prevalence of dyslipidemia and hypertension and underwent MRI more frequently in 2004.22777532
Congestive heart failure, Dyslipidemias, Atrial Fibrillation by ECG Finding, Diabetes MellitusDeregulated Nutrient SensingAtrial fibrillation, congestive heart disease and prior disability were significantly more common, while diabetes, current smoking and dyslipidemia were less frequent in the very elderly.22777655
Dyslipidemias, Smoking, Diabetes MellitusDeregulated Nutrient SensingSmoking, elevated blood pressure, dyslipidaemia, and a family history of diabetes were not associated with this perception.22781026
Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Chronic heart failure, Malignant Neoplasms, Hypertension, CTCAEDeregulated Nutrient SensingThe most frequent comorbidities were: hypertension (60.0%), ischemic heart disease (16.0%), malignant tumor (10.9%), diabetes mellitus (10.5%), chronic heart failure (9.9%) and dyslipidemia (9.9%).22781564
Obesity, Diabetes MellitusDeregulated Nutrient SensingIndividuals with obesity and abdominal adiposity are at higher risk for hypeinsulinaemia, insulin resistance, and diabetes.22783566
Prediabetes syndromeDeregulated Nutrient SensingReduction of insulin resistance and plasma glucose level by salsalate treatment in persons with prediabetes.22784842
Prediabetes syndromeDeregulated Nutrient SensingTo evaluate the effect of salsalate as an antiinflammatory agent on insulin resistance and glycemic control in persons with prediabetes.22784842
Prediabetes syndromeDeregulated Nutrient SensingTreatment with salsalate can reduce insulin resistance and the FPG level in subjects with prediabetes.22784842
Dyslipidemias, Congestive heart failureDeregulated Nutrient SensingStatin therapy attenuates the production of monocyte pro-inflammatory cytokines, and ameliorates the cardiac function and may improve long-term prognosis in CHF patients with dyslipidemia.22785006
Increased insulin level, Hepatobiliary Disorder, Liver carcinoma, HepatocarcinogenesisDeregulated Nutrient SensingHyperinsulinemia and/or insulin resistance in liver disease is associated with hepatocarcinogenesis, growth of hepatocellular carcinoma, and poor prognosis.22790351
Diabetes Mellitus, Glucose Intolerance (disease), Saint Lucia, Diabetes Mellitus, Non-Insulin-Dependent, Liver CirrhosisDeregulated Nutrient SensingGlucose intolerance in patients with liver cirrhosis (LC), known as hepatogenous diabetes, is thought to be distinct from type 2 diabetes (T2DM) in some aspects.22790351
Glucose Intolerance (disease)Deregulated Nutrient SensingEven among subjects with NGT, there is a significant increase in CIMT with increasing levels of HbA1c, showing the value of using HbA1c for diagnosis of glucose intolerance.22795336
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia and insulin resistance is associated with low T3/T4 ratio in pre diabetic euthyroid Pakistani subjects.22795338
Increased insulin levelDeregulated Nutrient SensingMarked hyperinsulinemia and insulin resistance were observed in IGT subjects.22795338
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are associated with low T3/T4 ratio in pre-diabetic euthyroid Pakistani subjects.22795338
Diabetes MellitusDeregulated Nutrient SensingFuture prospective studies are needed to further explore these associations to determine whether phthalate exposure can alter glucose metabolism and increase the risk of insulin resistance and diabetes.22796563
Amyotrophic Lateral Sclerosis, Neurodegenerative DisordersDeregulated Nutrient SensingSirtuins (SIRT1-7; class III histone deactylases) modulate fundamental mechanisms in age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS).22796962
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingWhen specifically analyzing mRNA and protein expression in the gray matter (cortical layers I-VI of the precentral gyrus, ventral/dorsal horn of the spinal cord) by in situ hybridization histochemistry and immunohistochemistry, we found increased levels of SIRT1, SIRT2 and SIRT5 in ALS which were significant for SIRT1 and SIRT5 mRNA in the spinal cord.22796962
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingNovel therapeutic approaches in ALS could therefore target SIRT1 activation or SIRT2 inhibition.22796962
ObesityDeregulated Nutrient SensingObesity, insulin resistance, and skeletal muscle nitric oxide synthase.22797309
diabeticDeregulated Nutrient SensingIncreased ferritin concentrations correlate with insulin resistance in female type 2 diabetic patients.22797673
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIron overload, which produces elevated levels of ferritin, may augment insulin resistance in female but not in male type 2 diabetes.22797673
Metabolic Syndrome X, Cerebral AtherosclerosisDeregulated Nutrient SensingMoreover, metabolic syndrome and insulin resistance were independent risk factors of moderate to severe ICAD but were not risk factors of moderate to severe extracranial atherosclerotic disease.22798326
Rheumatoid Arthritis, Dyslipidemias, Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingIn conclusion, vitamin D deficiency was associated with the metabolic syndrome and dyslipidemia in rheumatoid arthritis, suggesting a potential role in cardiovascular disease risk.22800875
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia has been associated with hepatic fat deposition and ensuing insulin resistance.22801247
Abnormality of mitochondrial metabolismDeregulated Nutrient SensingMitochondrial dysfunction is apparent only in inactive longstanding T2DM patients, which suggests that mitochondrial function and insulin resistance do not depend on each other.22802091
diabetic, Coronary Artery Disease, Edema, Heart failureDeregulated Nutrient SensingPioglitazone ameliorates insulin resistance, but has an adverse effect of oedema that may result in subsequent heart failure, especially in diabetic patients with coronary artery disease.22802358
Kidney Failure, Chronic, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingChronic kidney failure is associated with dyslipidemia and accelerated atherosclerosis.22811228
Diabetes MellitusDeregulated Nutrient SensingThe discovery of new adipokine, visfatin can significantly enhance our knowledge of insulin resistance and diabetes mellitus.22813406
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe explored the relation of visfatin concentrations to cardiovascular risk factors, adiponectin and insulin resistance criteria in patients with type 2 diabetes mellitus (T2DM).22813406
diabeticDeregulated Nutrient SensingIn conclusion high circulating levels of visfatin could be in healthy relations with cardiovascular risk factors, insulin resistance status and adiponectin in diabetic patients.22813406
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingInsulin resistance and obesity are associated in a proportion of Indian patients with NAFLD.22813407
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingReports of urban based studies suggest an increase in the prevalence of MS worldwide along with diabetes, hypertension and atherogenic dyslipidemia.22813408
Tuberculosis, PulmonaryDeregulated Nutrient SensingStudies have proven correlation between low vitamin D levels and pulmonary tuberculosis (PTB) and low vitamin D levels and insulin resistance.22813409
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance and alanine amino transaminase (ALT) levels in first degree relatives of type 2 diabetes mellitus.22813567
Atherosclerosis, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DiseaseDeregulated Nutrient SensingInsulin resistance is established as an independent predictor of a range of disorders such as obesity, hypertension, dyslipidemia, type 2 diabetes mellitus and atherosclerotic cardiovascular diseases.22813567
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingIn nonalcoholic fatty liver disease, there is an elevation of ALT, raising the possibility that the prospective relationship between ALT and type 2 diabetes may reflect cross-sectional associations with insulin resistance or obesity.22813567
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo find the significance of insulin resistance and alanine aminotransferase level in first degree relatives of type 2 diabetes mellitus.22813567
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingResults of the study conclude that there is a high prevalence of insulin resistance in the first degree relatives of type 2 diabetes mellitus.22813567
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingALT levels in the first degree relatives of type 2 diabetes mellitus had increased levels of insulin resistance, the pathogenesis suggesting increase in ALT levels as seen in insulin resistance condition.22813567
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama study.22814404
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingAlthough several surrogate measures of insulin resistance have been proposed, their associations with cardiovascular disease (CVD) have not been evaluated sufficiently.22814404
Metabolic Syndrome XDeregulated Nutrient SensingOur findings suggest that insulin resistance significantly increases the risk of incident CVD through metabolic syndrome in Japanese.22814404
Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity (AO) is a risk factor of insulin resistance and its metabolic consequences.22814438
ObesityDeregulated Nutrient SensingOxidative stress is associated with C-reactive protein in nondiabetic postmenopausal women, independent of obesity and insulin resistance.22816656
ObesityDeregulated Nutrient SensingWe tested the hypothesis that elevated levels of oxidative stress markers are associated with increased C-reactive protein (CRP) and that this is independent of obesity and insulin resistance.22816656
ObesityDeregulated Nutrient SensingThis finding was independent of obesity and insulin resistance in nondiabetic postmenopausal women.22816656
Inflammation, Malnutrition, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIn hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common.22817124
Diabetes MellitusDeregulated Nutrient SensingIn the Cox proportional hazards model, the risk of diabetes mellitus increased with increasing BMI, even after adjusting for age, sex, blood pressure, metabolic profiles, and insulin resistance.22821094
diabeticDeregulated Nutrient SensingTelmisartan at 80 mg/day increases high-molecular-weight adiponectin levels and improves insulin resistance in diabetic patients.22821644
Hypertension, CTCAE, diabeticDeregulated Nutrient SensingIn diabetic patients with hypertension, high-dose telmisartan increased HMW adiponectin levels and improved insulin resistance through activation of PPAR-gamma.22821644
Pre-Gestational DiabetesDeregulated Nutrient SensingPregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy.22825259
diabeticDeregulated Nutrient SensingPregnancy exacerbates insulin resistance in diabetic patients, and these patients may require high doses of insulin.22825259
Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingTraditional risk factor for cardiovascular disease such as hyperglycemia, hypertension, smoking, obesity, and dyslipidemia were assessed.22826078
vascular inflammationsDeregulated Nutrient SensingHowever, it remains unknown whether fasting serum levels of apoB48 are independently correlated with insulin resistance and vascular inflammation in humans.22827961
DyslipidemiasDeregulated Nutrient SensingCigarette smoking had been confirmed as an increased risk for dyslipidemia, but none of the evidence was from long-lived population.22828289
DyslipidemiasDeregulated Nutrient SensingIn summary, we found that among Chinese nonagenarians/centenarians, cigarette smoking habits were not associated with increased risk for dyslipidemia, which was different from the association of smoking habits with dyslipidemia in general population.22828289
Diabetes MellitusDeregulated Nutrient SensingMajor liver resection results in early exacerbation of insulin resistance, and may be a risk factor of developing overt diabetes in the future.22829443
Hyperlipidemia, SteatohepatitisDeregulated Nutrient SensingSkeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly.22829450
Hyperlipidemia, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAging is closely associated with muscle insulin resistance, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes.22829450
HyperlipidemiaDeregulated Nutrient SensingWe examined the hypothesis that muscle insulin resistance in healthy aging promotes increased hepatic de novo lipogenesis (DNL) and hyperlipidemia by altering the distribution pattern of postprandial energy storage.22829450
Hyperlipidemia, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese results strongly support the hypothesis that muscle insulin resistance in aging promotes hyperlipidemia and NAFLD by altering the pattern of postprandial carbohydrate storage away from muscle glycogen and into hepatic DNL.22829450
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn addition, hypertension and dyslipidaemia were the most common risk factors (58% and 40%).22829507
DyslipidemiasDeregulated Nutrient SensingDietary and/or physical activity induced changes in CRP may be largely independent of traditional CVD risk factors in persons with dyslipidemia.22831953
AtherosclerosisDeregulated Nutrient SensingFish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS).22835984
AtherosclerosisDeregulated Nutrient SensingWe examined the cross-sectional association between fish consumption and measures of insulin sensitivity and secretion in 951 non-diabetic participants in the Insulin Resistance Atherosclerosis Study (IRAS).22835984
Alzheimers DiseaseDeregulated Nutrient SensingSORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease.22836009
TG gene, DyslipidemiasDeregulated Nutrient SensingWe assessed the prevalence of high LDL-C, low HDL-C, high TG, high non-HDL-C, and mixed dyslipidemia by using National Health and Nutrition Examination Survey (NHANES) data to estimate the proportions of U.S. adults not at guideline-recommended lipid goals.22836069
TG gene, DyslipidemiasDeregulated Nutrient SensingAlso, 21% (42.0M) of U.S. adults have mixed dyslipidemia (high LDL-C with either low HDL-C and/or high TG), with nearly 6% (11.6M) having all three lipid abnormalities.22836069
DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia in the United States continues to be high, with the majority of U.S. adults now affected by some form of lipid abnormality.22836069
indicine-N-oxide, DyslipidemiasDeregulated Nutrient SensingDiet and dyslipidemias in a Lithuanian rural population aged 25-64: the CINDI survey.22836294
AtherosclerosisDeregulated Nutrient SensingLevels of four urinary F(2)-isoprostanes (F(2)-IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non-Hispanic whites (NHWs), and 275 Hispanic whites (HWs).22836686
Steatohepatitis, Prostate Cancer Outcomes Study, Obesity, Hyperandrogenism, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance.22837189
Prostate Cancer Outcomes Study, Non-alcoholic Fatty Liver Disease, Polycystic Ovary Syndrome, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease may be evident in women with polycystic ovary syndrome (PCOS), both conditions being associated with obesity and insulin resistance.22837189
Steatohepatitis, ObesityDeregulated Nutrient SensingThese data suggest that HA-PCOS is associated with hepatic steatosis, independent of obesity and insulin resistance.22837189
Chief complaint (finding), Diabetes MellitusDeregulated Nutrient SensingSubjective sleep complaints are associated with insulin resistance in individuals without diabetes: the PPP-Botnia Study.22837368
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe evidence with respect to insulin resistance (IR) and insulin secretion in individuals without type 2 diabetes has been scarce and elusive.22837368
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCrude mortality was highest in patients with MI with diabetes (11.9%) and hypertension (9.8%) and lowest in those with smoking histories (5.4%) and dyslipidemia (4.6%).22840346
Fibrinolysis, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingHypofibrinolysis displayed by elevated serum plasminogen activator inhibitor 1 (PAI-1) level has been associated with cardiovascular disease (CVD) and its risk factors such as obesity and insulin resistance.22840426
HyperandrogenemiaDeregulated Nutrient SensingSevere hyperandrogenemia and insulin resistance in a 12-year-old girl.22840945
NeoplasmsDeregulated Nutrient SensingThis is the first phase I, dose-finding study of AZD8055, a first-in-class dual mTORC1/2 inhibitor, in Japanese patients with advanced solid tumors.22843211
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingResistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease.22843503
acetate-CoA ligase activityDeregulated Nutrient SensingCACS, lipids, lipoproteins, inflammatory markers, insulin resistance and PON1 activity, concentration and Q192R and L55M genotypes were measured.22846213
Dyslipidemias, AmyloidosisDeregulated Nutrient SensingRevisiting secondary amyloidosis for an inadequately investigated feature: dyslipidemia.22847292
Dyslipidemias, Reactive systemic amyloidosisDeregulated Nutrient SensingData on frequency and nature of dyslipidemia in patients with secondary amyloidosis are not conclusive.22847292
Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingDyslipidemia was closely associated with GFR in a manner that patients with advanced stage kidney disease had lower serum lipid levels.22847292
Cholelithiasis, Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) and gallstone disease (GD) are both highly prevalent in the general population and associated with obesity and insulin resistance.22848440
Steatohepatitis, Non-alcoholic Fatty Liver Disease, Dyslipidemias, Liver CirrhosisDeregulated Nutrient SensingNon-alcoholic fatty liver disease is associated with insulin resistance and dyslipidaemia and can progress to steatohepatitis and cirrhosis.22849970
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingLow-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia.22850442
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingSeveral large-scale studies have shed light on the primary preventive efficacy of statins against atherosclerotic diseases in the course of treatment of dyslipidemia.22850442
Dyslipidemias, Coronary Artery Disease, Stiff toeDeregulated Nutrient SensingThe potent statin improves baPWV and carotid stiffness b, in addition to CIMT (surrogate markers of coronary artery disease), in postmenopausal women with low-risk dyslipidemia.22850442
Hypertensive (finding)Deregulated Nutrient SensingPPARg immunostaining level was significantly lower in diabetics, hypertensive and insulin resistance patients (P<0.05).22853971
Inflammation, Colorectal NeoplasmsDeregulated Nutrient SensingDietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation.22854408
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe effect of insulin resistance on postprandial triglycerides in Korean type 2 diabetic patients.22854916
Diabetes Mellitus, Insulin-Dependent, Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance has been documented in type 1 diabetes and may contribute to the high risk for cardiovascular disease in this population and progression of nephropathy.22856231
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingInsulin resistance, measured with eGDR, predicts the increment in UAE in subjects with type 1 diabetes.22856231
Microalbuminuria, diabeticDeregulated Nutrient SensingSince progression to microalbuminuria is likely to occur in majority of diabetic patients, there is a need to further explore the role of risk factors such as insulin resistance.22856231
Dyslipidemias, Restenosis, Diabetes MellitusDeregulated Nutrient SensingFemale sex (1*79, 1*25-2*56), diabetes (2*31, 1*61-3*31), and dyslipidaemia (2*07, 1*01-4*26) were independent predictors of restenosis or occlusion after the two procedures.22857850
Vertigo, Atrial Fibrillation by ECG Finding, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingMiddle aged male, diabetes, hypertension, dyslipidemia, coronary artery disease, and atrial fibrillation are risk factors for subsequent stroke in vertigo patients.22858717
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingYoung adults had lower levels of high-density lipoprotein cholesterol, less glucose intolerance, and less hypertension.22863157
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingThe liver-derived Fetuin-A (a2-Heremans Schmid glycoprotein) is a circulating glycoprotein that may be related to insulin resistance and polycystic ovary syndrome (PCOS).22865037
SarcopeniaDeregulated Nutrient SensingHowever, the gender effects on muscle strength, lean tissue in the arms, homeostatic assessment of insulin resistance, and body weight detected in this study suggest that additional research is needed on elderly male subjects with sarcopenia.22866000
Lipodystrophy, DisturbanceDeregulated Nutrient SensingLipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated with a high prevalence of glucose disturbances and insulin resistance.22866963
Lipodystrophy, DisturbanceDeregulated Nutrient SensingFMR lipodystrophy definition seems to be a more sensitive determinant of insulin resistance and glucose disturbances than clinical definition.22866963
Hypertensive (finding)Deregulated Nutrient SensingIn vivo sitagliptin treatment elevated GLP-1 and GLP-1 receptor expressions, increased cAMP level, and subsequently activated protein kinase A, liver kinase B1, AMP-activated protein kinase-a and endothelial NO synthase in spontaneously hypertensive rat renal arteries.22868389
HyperglycemiaDeregulated Nutrient SensingIdentification of possible predictors (demographic, clinical, or genetic) for insulin resistance and glycaemic control during severe/acute hyperglycaemia.22869200
HyperglycemiaDeregulated Nutrient SensingThe use of loop diuretics (P < 0.05) and antibiotics (P < 0.05) may indirectly predict worsening of insulin resistance or glycaemic control in patients with severe/acute hyperglycaemia.22869200
HyperglycemiaDeregulated Nutrient SensingClinical and genetic factors contribute to worsening of insulin resistance and glycaemic control during severe/acute hyperglycaemia in patients with T2DM.22869200
HyperglycemiaDeregulated Nutrient SensingEarly identification of factors that may influence insulin resistance and glycaemic control may help to achieve optimal glycaemic control during severe/acute hyperglycaemia.22869200
Coronary Artery DiseaseDeregulated Nutrient SensingMost studies pay attention to the relationship between insulin resistance and coronary artery disease (CAD) in patients with abnormal glucose tolerance.22871300
ObesityDeregulated Nutrient SensingWhether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known.22872690
ObesityDeregulated Nutrient SensingAlthough males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex.22872690
Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingAt baseline, data were collected on diabetes and major risk factors for mortality: social network, diet, physical activity and other lifestyle factors, obesity, hypertension, dyslipidemia, and previous cardiovascular disease and cancer.22875228
ARCN1 gene, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingUnderweight might be more prevalent but coronary heart disease and dyslipidemia are less prevalent in Koreans with than without COPD in population setting.22876057
deficiency aspectsDeregulated Nutrient SensingThe balance between insulin deficiency and insulin resistance is variable at different phases of the condition.22876561
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT).22876749
Dyslipidemias, physiopathologicalDeregulated Nutrient SensingDyslipidemia is associated with dysfunction of pancreatic b cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males.22876749
Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingIn patients without known CHD, cardiovascular risk factors were abundant (52.1% had hypertension, 43.6% had dyslipidemia, 41.4% had a family history of CHD, 58.5% were current or former smokers, and 14.9% were diabetic).22877813
physiopathological, Diabetes MellitusDeregulated Nutrient SensingUsing multivariate logistic regression analysis, low high-density lipoprotein cholesterol (HDL-C, P < .036), newly diagnosed non-insulin-dependent diabetes or insulin-resistance (NIDD/IR, P < .019) and the use of diuretics (P = .001) were independently associated with overt LV dysfunction.22879076
DyslipidemiasDeregulated Nutrient SensingThe incidence of dyslipidemia increased with aging (P < 0.01).22883098
TG gene, Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingAfter adjusted for age, sex, dyslipidemia and other risk factors, high TG group (TG>=2.26 mmol/L) appeared a significant independent predictor of newly identified carotid plaque (OR=1.37, 95%CI: 1.00-1.86).22883168
Dyslipidemias, Dental PlaqueDeregulated Nutrient SensingAfter adjusting age, sex, dyslipidemia and other risk factors, serum fasting TG>=2.26 mmol/L appeared to be an independent predictor of newly developed carotid plaque.22883168
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingLow blood HDL-C and hypertriglyceridemia are two major types of dyslipidemia in Chinese adults.22883727
Inflammation, Obesity, Abdominal, Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAfter adjustment for BMI, social-demographic, lifestyle and dietary factors and other TFAs, erythrocyte trans-18:1 was shown to be associated with a lower risk of type 2 diabetes (OR comparing extreme [first and fourth] quartiles 0.68, 95% CI 0.48, 0.97, p(trend) = 0.02), as well as 20-50% lower odds of central obesity, dyslipidaemia, hyperglycaemia, insulin resistance and chronic inflammation.22886370
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigher trans-18:1 levels were associated with a lower risk of type 2 diabetes, whereas higher trans-18:2 levels were associated with dyslipidaemia.22886370
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt is indicated as a method of choice in accompanied atherogenic dyslipidemia and in patients, suffering diabetes mellitus type II.22888543
Heart failureDeregulated Nutrient SensingInsulin resistance and exercise tolerance in heart failure patients: linkage to coronary flow reserve and peripheral vascular function.22889317
Heart failure, Impaired exercise toleranceDeregulated Nutrient SensingInsulin resistance has been linked to exercise intolerance in heart failure patients.22889317
Heart failure, Impaired exercise toleranceDeregulated Nutrient SensingThe study confirms that insulin resistance is associated with exercise intolerance in heart failure patients and suggests that this is partly through reduced CFR.22889317
Heart failureDeregulated Nutrient SensingThis is the first study to our knowledge that shows an association between CFR and exercise capacity in heart failure patients and links the relationship between insulin resistance and exercise capacity to CFR.22889317
NeoplasmsDeregulated Nutrient SensingLactate dehydrogenase (LDH) is an enzyme involved in anaerobic glycolysis and regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (mTOR)-containing complex 1 (PI3K/Akt/TORC1) pathway as well as tumor hypoxia/necrosis.22891270
Refractory Cytopenia of ChildhoodDeregulated Nutrient SensingWe evaluated pretreatment and post-treatment serum LDH in 404 poor-risk patients with RCC treated with the TORC1 inhibitor temsirolimus or interferon alfa in an international phase III randomized trial.22891270
Refractory Cytopenia of ChildhoodDeregulated Nutrient SensingSerum LDH is a prognostic and a predictive biomarker for the survival benefit conferred by TORC1 inhibition in poor-risk RCC.22891270
Refractory Cytopenia of Childhood, NeoplasmsDeregulated Nutrient SensingFurther investigation of the predictive role of LDH as a measure of benefit with PI3K/TORC1 pathway inhibition in other RCC risk groups and other tumor types is warranted.22891270
Impaired cognitionDeregulated Nutrient SensingBenefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study.22892813
Autoimmune Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was found in 69.4% of patients, 60% of FDR and 40.9% of controls (p < 0.0001 and p = 0.003 respectively), autoimmune diseases in 36.9% of patients, 30.4% of FDR and 13.4% of controls (p < 0.0001 and p = 0.011 respectively).22898439
Autoimmune Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia and autoimmune diseases were significantly increased not only in patients as expected but also in their FDR.22898439
Diabetes Mellitus, Non-Insulin-Dependent, Prostate carcinoma, Structure of posterior cerebral arteryDeregulated Nutrient SensingAndrogen deprivation therapy (ADT) for prostate cancer (PCa) may increase peripheral insulin resistance, induce type 2 diabetes, change body composition, and alter lipoprotein profile.22898989
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, pediatric DALT occurred in non-obese adolescents with insulin resistance, distinct from diabetes types 1 or 2.22905982
Microalbuminuria, Dyslipidemias, diabeticDeregulated Nutrient SensingPrevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital.22906862
Dyslipidemias, Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingAccumulating evidence indicates that dyslipidaemia plays an important role in the progression of kidney disease in patients with diabetes.22906862
Microalbuminuria, Dyslipidemias, diabeticDeregulated Nutrient SensingLittle information exists on the prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in China.22906862
Microalbuminuria, Dyslipidemias, diabeticDeregulated Nutrient SensingThe aims of this study were to investigate the prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital as well as factors affecting the disease.22906862
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingFewer patients with microalbuminuria were adherent to the therapy prescribed for dyslipidaemia (28.8% vs. 43.3%, p < 0.001).22906862
Microalbuminuria, Dyslipidemias, diabeticDeregulated Nutrient SensingIn China, diabetic patients with microalbuminuria displayed typical dyslipidaemias and were not adequately controlled.22906862
Renal Cell CarcinomaDeregulated Nutrient SensingInsulin resistance and risk of renal cell cancer: a case-control study.22908063
Refractory Cytopenia of ChildhoodDeregulated Nutrient SensingWe aimed to explore whether insulin resistance (IR) plays an independent role in the development of RCC.22908063
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingWe assessed insulin resistance according to insulin levels, alone or controlled for diabetes mellitus (DM).22908063
Refractory Cytopenia of Childhood, Demographics DomainDeregulated Nutrient SensingInsulin levels controlled or not controlled for DM, however, were inversely associated with the risk for RCC; notably, an approximately 40% higher risk was observed in the 1st tertile when compared with the 2nd and 3rd tertile levels of insulin resistance.22908063
Refractory Cytopenia of Childhood, Demographics Domain, ObesityDeregulated Nutrient SensingOur curdata suggest that insulin resistance may be inversely associated with RCC risk, independently of obesity, DM, lifestyle and hormonal confounding variables.22908063
Obesity, HaitiDeregulated Nutrient SensingAmong the adipokines analyzed, the most notable finding was a 15% lower level of monocyte chemotactic protein-1 in HT users, particularly with respect to its suggested mediator role between obesity and insulin resistance.22914204
Hyperglycemia, Critical IllnessDeregulated Nutrient SensingCritically ill patients often present increased insulin resistance and stress-induced hyperglycemia.22917085
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingCardiovascular risk factors were mainly smoking (60.5%), dyslipidaemia (46.0%), diabetes (51.4%) and hypertension (56.0%).22917780
Obesity, AbdominalDeregulated Nutrient SensingThis first longitudinal study of GDF-15 in a large cohort of obese individuals indicates that GDF-15 is related to abdominal obesity and insulin resistance and independently associated with future insulin resistance and abnormal glucose control.22918303
Diabetes MellitusDeregulated Nutrient SensingChildren and young adults treated with total body or abdominal radiotherapy have an increased risk of insulin resistance and diabetes mellitus.22921663
Reproductive dehiscence, Vascular Diseases, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThis is the first reported case of ALGS with TOF/PA/MAPCAs and catastrophic shunt dehiscence due to significant generalized vasculopathy caused by dyslipidemia and atherosclerosis.22923029
Dyslipidemias, ComorbidityDeregulated Nutrient SensingDyslipidemia, a known comorbidity in ALGS, is one of few modifiable risk factors that should be screened for and treated, particularly before cardiac surgery.22923029
Lichen Planus, DyslipidemiasDeregulated Nutrient SensingRecently, a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients.22924867
Sensorineural Hearing Loss (disorder), Myoclonus, Leukoencephalopathy, Myopathy, Hypertrophic CardiomyopathyDeregulated Nutrient SensingSporadic myopathy, myoclonus, leukoencephalopathy, neurosensory deafness, hypertrophic cardiomyopathy and insulin resistance associated with the mitochondrial 8306 T>C MTTK mutation.22925535
Autoimmune Diseases, Primary malignant neoplasm, Metabolic Diseases, ObesityDeregulated Nutrient SensingInsufficient vitamin D status has been linked to autoimmune diseases, cancer and metabolic disorders, like obesity and insulin resistance.22925537
diabeticDeregulated Nutrient SensingWe previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats.22930403
Dyslipidemias, Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingIt has been long suggested that abnormal clinical factors in the body, such as dyslipidemia and diabetes, can affect the presence of atherosclerosis.22931970
Nausea, Weight decreasedDeregulated Nutrient SensingExenatide demonstrated more beneficial effects on HbA(1C), weight reduction and insulin resistance during 26 weeks of treatment, but there were more hypoglycemic events and mild-to-moderate nausea compared with metformin.22931974
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingRelationships of the Mediterranean dietary pattern with insulin resistance and diabetes incidence in the Multi-Ethnic Study of Atherosclerosis (MESA).22932232
Metabolic Syndrome X, Cardiovascular morbidity, Prostate Cancer Outcomes Study, Diabetes Mellitus, Hyperandrogenism, Polycystic Ovary SyndromeDeregulated Nutrient SensingHyperandrogenism and insulin resistance are also key features of polycystic ovary syndrome (PCOS), and women with PCOS are consequently at an increased risk of developing type 2 diabetes mellitus and/or metabolic syndrome, and may have increased cardiovascular morbidity.22933528
DyslipidemiasDeregulated Nutrient SensingA central/visceral fat distribution and excess free fatty acid (FFA) availability are associated with dyslipidemia and insulin resistance.22933539
Hypertension, CTCAEDeregulated Nutrient SensingNo associations were observed between NAE and cardiovascular risk factors, such as hypertension and insulin resistance.22935845
Glucose Intolerance (disease), Liver diseases, Malignant Neoplasms, HyperuricemiaDeregulated Nutrient SensingThis disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways.22937763
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingA total of 1360 (8.5%) NOD cases were identified among 16,027 patients with hypertension and dyslipidemia during the study period.22939164
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThese outpatients with hypertension and dyslipidemia who took fluvastatin, lovastatin, and rosuvastatin were at lower risk of NOD, whereas patients who took pravastatin were at greater risk.22939164
DyslipidemiasDeregulated Nutrient SensingFactors related to the presence of RAS were diastolic blood pressure, glomerular filtration rate and dyslipidaemia.22939809
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingWaist circumference (WC), a surrogate indicator of abdominal fat mass, is used to measure central obesity associated with increased risk of hypertension, insulin resistance and type 2 DM, whereas body mass index (BMI) is traditionally used to measure somatic obesity.22941134
Inflammation, InsufficiencyDeregulated Nutrient SensingAnd microinflammation and insulin resistance are closely correlated with the insufficiency and deficiency of 25(OH)D. The independent influencing factors of serum 25(OH)D are hsCRP, RI, LDL and age.22944160
DyslipidemiasDeregulated Nutrient SensingThe prevalence of overweight/obesity and dyslipidaemia observed in these children is a matter of concern considering the age group evaluated.22946122
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingEffects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease: rationale and design of the ASsessment of clinical Usefulness in CKD patients with Atorvastatin (ASUCA) trial.22948416
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingSince dyslipidemia has been shown to be an independent risk factor for the progression of chronic kidney disease (CKD), low-density lipoprotein cholesterol (LDL-C)-lowering therapy can be potentially associated with inhibition of CKD progression.22948416
Metabolic Diseases, ObesityDeregulated Nutrient SensingLeptin, however, strongly correlated with insulin resistance independently of fat masses, suggesting that obesity, as a metabolic disorder risk factor, affects glucose metabolism, partly through the role of leptin.22948754
DyslipidemiasDeregulated Nutrient SensingDevelopment and evaluation of a simple and effective prediction approach for identifying those at high risk of dyslipidemia in rural adult residents.22952780
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is an extremely prevalent but preventable risk factor for cardiovascular disease.22952780
DyslipidemiasDeregulated Nutrient SensingHowever, many dyslipidemia patients remain undetected in resource limited settings.22952780
Dyslipidemias, ObesityDeregulated Nutrient SensingSome risk factors were significantly associated with dyslipidemia, including age, gender, educational level, smoking, high-fat diet, vegetable and fruit intake, family history, physical activity, and central obesity.22952780
Type II Endometrial AdenocarcinomaDeregulated Nutrient SensingThe mammalian target of rapamycin in the nuclei (mTORC2; 47%) or cytoplasm (mTORC1; 48%) were seen in type II endometrial carcinoma, the latter also in advanced stages (P <= .046).22955108
Stomach CarcinomaDeregulated Nutrient SensingPhosphorylated AMP-activated protein kinase expression associated with prognosis for patients with gastric cancer treated with cisplatin-based adjuvant chemotherapy.22955258
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingNAFLD patients were older, had higher BMI, larger waist circumference, higher sum of skinfolds, more likely to have insulin resistance (HOMA > 3.0) and type-2 diabetes (all P-values <0.01).22958053
Pancreatic carcinomaDeregulated Nutrient SensingAdrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in b cells and mice.22960655
Glucose Intolerance (disease), Pancreatic carcinomaDeregulated Nutrient SensingConversely, overexpression of adrenomedullin in mice with pancreatic cancer led to glucose intolerance.22960655
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingIron metabolism is associated with adipocyte insulin resistance and plasma adiponectin: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study.22961568
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdipocyte insulin resistance (IR) is a key feature early in the pathogenesis of type 2 diabetes mellitus (T2DM), and although scarce, data in the literature suggest a direct role for iron and iron metabolism-related factors in adipose tissue function and metabolism.22961568
DyslipidemiasDeregulated Nutrient SensingSubjects with dyslipidemias and T2DM had, respectively, 2.3 and 2.6-fold higher sd-LDL-C concentrations than normolipidemic individuals (p<0.05).22962227
TG geneDeregulated Nutrient SensingGERD symptoms were correlated with insulin resistance (r = 0.167, p = 0.011), total cholesterol (T-CHO) (r = 0.138, p = 0.034), triglyceride (TG) (r = 0.178, p = 0.006), or immunoreactive insulin (r = 0.173, p = 0.008) but not BMI (r = 0.089, p = 0.175).22964626
Obesity, AbdominalDeregulated Nutrient SensingAssociation of the apolipoprotein B/apolipoprotein A-I ratio and low-density lipoprotein cholesterol with insulin resistance in a Chinese population with abdominal obesity.22965469
Obesity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort.22966089
Obesity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and truncal obesity account for the twofold excess incidence of diabetes in Indian Asian and African Caribbean women, but not men.22966089
Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Chronic disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe top four relevant chronic diseases of stroke patients were hypertension, dyslipidemia, obesity and diabetes mellitus.22968008
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBeyond atherogenic dyslipidemia, high-Trg/normal HDL-cholesterol category was associated with elevated CRP and diabetes risk in women.22968297
Prostate carcinomaDeregulated Nutrient SensingElevated insulin and insulin resistance are associated with the advanced pathological stage of prostate cancer in Korean population.22969256
Prostate carcinomaDeregulated Nutrient SensingThese results suggest that elevated insulin and insulin resistance are associated with the advanced pathological stage of prostate cancer in Korean patients.22969256
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAdherence rates to recommended guidelines for coronary artery disease, hypertension, and dyslipidemia were high (>75%); however <50% of patients were at target for blood pressure or LDL-cholesterol levels (37.1% and 49.7% respectively), and only 59.3% of patients with diabetes were at target for hemoglobin-A1c.22970753
Hypertension, CTCAE, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingDespite high adherence rates for hypertension, dyslipidemia, and coronary artery disease, a significant proportion of patients failed to meet treatment targets, highlighting the complexity of caring for people with multiple chronic conditions.22970753
Cardiovascular DiseasesDeregulated Nutrient SensingSerum gamma-glutamyltransferase (GGT) levels, which are associated with insulin resistance, may predict the incidence of cardiovascular disease and mortality.22972431
Pulmonary arterial hypertension, Polycyclic Hydrocarbons, AromaticDeregulated Nutrient SensingPatients with pulmonary arterial hypertension (PAH) exhibit impaired glucose metabolism and increased insulin resistance.22975101
Gastroesophageal reflux disease, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSubjects undergoing treatment for hypertension showed an increased risk of GERD, while those undergoing treatment for dyslipidemia and diabetes mellitus showed a decreased risk.22976934
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOf these risk factors, hypertension and dyslipidemia are significantly associated with increased cIMT.22977209
Obesity, Abdominal, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOlder age, male gender, metabolic factors such as obesity, abdominal obesity, dyslipidemia, hypertension or type 2 diabetes are risk factors for NAFLD.22978800
Atrial Fibrillation by ECG FindingDeregulated Nutrient Sensing[Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation].22980663
Atrial Fibrillation, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingTo observe the expression of mammalian sirtuin 1 (SIRT1) in right auricle tissues in patients presenting with atrial fibrillation (AF) and make clear the relationship between SIRT1 expression and oxidative stress.22980663
SLC25A20 gene, Chronic Kidney DiseasesDeregulated Nutrient SensingIn conclusion, these data indicate that abnormal calcium and phosphate metabolism, insulin resistance, and declining kidney function are associated with the prevalence of high CAC, independent of the traditional risk factors in patients with CKD.22980963
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingConventional atherosclerotic markers and LDL particle size (LDL-PS), as determined by gel electrophoresis, were measured in 155 non-diabetic subjects (mean age of 57 years) with dyslipidemia.22981508
DyslipidemiasDeregulated Nutrient SensingThese results suggest that high PG levels may contribute to the HDL oxidation, irrespective of HDL-cholesterol levels, even in non-diabetic subjects with dyslipidemia, and that the measurement of oxHDL may be a useful marker of dysfunctional HDL.22981508
KeloidDeregulated Nutrient SensingKeloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor.22982188
Dyslipidemias, Brain hemorrhage, Cerebrovascular accident, Deglutition Disorders, Hypertension, CTCAEDeregulated Nutrient SensingPresence of limb weakness, dysphagia, dyslipidemia, hypertension, hemorrhagic stroke, severe stroke, and poor outcome predicted the use of CAM.22982825
Non-insulin HypoglycemicDeregulated Nutrient SensingThere were also significant differences of mean on fat mass, fat mass (%), waist circumference, peripheral subcutaneous fat, trunk subcutaneous fat, which were significantly higher in insulin-resistance group compared to the non-insulin resistance group.22983074
Hypertriglyceridemia, Dyslipidemias, Hypercholesterolemia, FamilialDeregulated Nutrient SensingHyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, impaired glucose tolerance (IGT), and WCH had a similar fashion with excess weight by increasing until the seventh decade and decreasing afterwards (p<0.05 nearly in all steps).22983077
Sleep Apnea, CTCAE, AcromegalyDeregulated Nutrient SensingSleep Apnea is highly prevalent and may contribute to insulin resistance in patients with acromegaly.22983689
ObesityDeregulated Nutrient SensingThe association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents.22984471
ObesityDeregulated Nutrient SensingUpper tCys quartile was independently associated with a 5-fold increased risk of obesity (95% CI 3.5-8.0, P<0.001), and 2-fold risk of insulin resistance (95% CI: 1.6-5.0, P<0.001; adjusted for body fat%).22984471
Polycystic Ovary SyndromeDeregulated Nutrient SensingAdipose tissue insulin resistance in peripubertal girls with first-degree family history of polycystic ovary syndrome.22985947
Prostate Cancer Outcomes Study, LipolysisDeregulated Nutrient SensingGirls at high risk of developing PCOS display increased adiposity and 17-OHP levels, but are mainly characterized by global insulin resistance and resistance to insulin-induced suppression of lipolysis that were independent of adiposity and 17-OHP levels.22985947
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingTherefore, genetic predisposition to PCOS may be related to early insulin resistance and adipocyte dysfunction.22985947
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingTotal OSI associated significantly with DM type 2, arterial hypertension, and dyslipidemia in both genders.22986427
Malignant tumor of colonDeregulated Nutrient SensingIn addition, in vitro studies were performed using colon cancer cell lines to study the serial changes of LKB1, LGR5 and PRKAA1 (AMPK) gene expression levels after irradiation.22986809
Hypertension, CTCAEDeregulated Nutrient SensingIn conclusion, GSPE increase eNOS expression and NO production in an AMPK/SIRT1 dependent manner through KLF2 induction, and attenuate ouabain induced hypertension.22987017
Diabetes MellitusDeregulated Nutrient SensingDietary patterns are associated with insulin resistance in Chinese adults without known diabetes.22989490
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, dietary patterns were significantly associated with insulin resistance in Chinese adults without known diabetes.22989490
Obesity, Diabetes MellitusDeregulated Nutrient SensingA dysfunctional adiposity phenotype, characterized by excess visceral fat and insulin resistance, may contribute to diabetes development in those with obesity.22990274
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingExcess visceral fat and insulin resistance, but not general adiposity, were independently associated with incident prediabetes and type 2 diabetes mellitus in obese adults.22990274
Nucleus PulposusDeregulated Nutrient SensingSIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway.22990594
Autoimmune DiseasesDeregulated Nutrient SensingAmong DA-positive youth, there was a progressive decline in beta cell function of 4% per month, independent of demographics (age, sex, race/ethnicity), genetic susceptibility to autoimmunity (HLA risk), HbA(1c) and BMI z score, or presence of insulin resistance.22990715
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingDiabetic patients with a positive stress test showed higher prevalence of hypertension (36%) and dyslipidaemia (84%) compared with diabetic patients with a negative stress test (12% and 28%, respectively) [p < 0.001].22994582
DyslipidemiasDeregulated Nutrient SensingAnalysis 2: comparable rates of dyslipidaemia to SPANS 2004 but lower rates compared to the AHFS, 1985.22998088
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is one of the most modifiable risk factors in preventing heart disease.22998096
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingEvidence demonstrates that the process of atherosclerosis, a result of dyslipidemia, begins in young adults.22998096
Hypertension, CTCAE, Obesity, Cerebrovascular accidentDeregulated Nutrient SensingChronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality.22998737
Non-alcoholic Fatty Liver Disease, Cardiovascular DiseasesDeregulated Nutrient SensingThese results support a beneficial effect of the non-alcoholic fraction of red wine (mainly polyphenols) on insulin resistance, conferring greater protective effects on cardiovascular disease to red wine than other alcoholic beverages.22999066
Electrocardiogram: myocardial infarction (finding), Endothelial dysfunctionDeregulated Nutrient SensingIn young post-myocardial infarction male patients elevated plasminogen activator inhibitor-1 correlates with insulin resistance and endothelial dysfunction.23001714
Endothelial dysfunctionDeregulated Nutrient SensingThe aim of the present study was to find out whether insulin resistance and impaired fibrinolysis, with increased plasminogen activator inhibitor (PAI-1), are present in young male post-MI patients, and their relation to additional markers of cardiovascular risk such as endothelial dysfunction (ED) and intima-media thickness (IMT).23001714
ObesityDeregulated Nutrient SensingOur results suggest that PAI-1 can be a link between obesity, insulin resistance, and MI in young patients.23001714
Ancriviroc, SteatohepatitisDeregulated Nutrient SensingHowever, the emergence of anti-CL in CH-C patients was independent of insulin resistance, hepatic steatosis, and iron overload.23001979
Atherosclerosis, Aortic Aneurysm, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingPatients with ascending aortic aneurysms had 0.131-mm lower carotid IMT values than controls (p = 0.0002), independent of risk factors for atherosclerosis (age, BMI, gender, family history, smoking, dyslipidemia, race, diabetes and hypertension).23006774
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingBMI, male gender, positive family history, dyslipidemia, diabetes and hypertension also increased the IMT, but did not reach statistical significance.23006774
Left Ventricular HypertrophyDeregulated Nutrient SensingWe conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals.23006812
Anxiety, CTCAE 3.0, Hypertensive (finding), Depression, CTCAE, ObesityDeregulated Nutrient SensingObesity, insulin resistance (HOMA), Doppler Renal Resistive Index (RRI) and glomerular filtration rate (GFR) are studied along with Psychological Stress Measure (PSM), Illness Perception Questionnaire (IPQ-R), Generalized Self-Efficacy scale (GSE) and Hospital Anxiety and Depression Scale (HADS) in 119 hypertensive patients referred for stable lasting EH, and 150 normal controls.23007813
ObesityDeregulated Nutrient SensingBy Odds Ratios, higher risk of EH is associated with greater perceived stress, older age, lower GFR, obesity, greater RRI and insulin resistance.23007813
Hypertriglyceridemia, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHypertriglyceridemia and residual dyslipidemia in statin-treated, patients with diabetes at the highest risk for cardiovascular disease and achieving very-low low-density lipoprotein-cholesterol levels.23009779
DyslipidemiasDeregulated Nutrient SensingThe only LDL-C at goal group had lower HDL-C (vs. all three at goal): 41 (12) vs. 47 (14) mg/dL (P = .0237), with atherogenic dyslipidemia [hypo-HDL-C + hyper-TG] prevalence of 35% in the all three at goal versus 56% in the only LDL-C at goal group (P < .0001).23009779
Hypercholesterolemia, Dyslipidemias, Failure (biologic function)Deregulated Nutrient SensingThe presence of atherogenic dyslipidemia was associated with a failure to meet all three critical modifiable targets for hypercholesterolemia, such a nonachievement being found in a large proportion (one-third) of very-high risk T2DM patients with very-low on-statin LDL-C. Attainment of all three targets will require (1) titration/permutation of statins, (2) lifestyle (re)inforcement; and/or (3) statin-fibrate bitherapy.23009779
Diabetes, AutoimmuneDeregulated Nutrient SensingOur findings indicate that psychosocial factors influence the risk of autoimmune diabetes in adults, possibly through mechanisms related to insulin resistance.23010555
Cardiovascular DiseasesDeregulated Nutrient SensingPeople with metabolically obese, normal-weight (MONW) phenotype, characterized by insulin resistance, are vulnerable to cardiovascular disease even though they are not physically obese.23010880
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIndividuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time.23011353
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes.23011353
Inflammation, AtherosclerosisDeregulated Nutrient SensingA-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals.23013043
Dyslipidemias, OverweightDeregulated Nutrient SensingThe most prevalent risk factors were being overweight (70% of patients had a BMI over 25), dyslipidaemia (70% of patients) and smoking (43% of patients).23013637
Prostate Cancer Outcomes Study, Complication AspectsDeregulated Nutrient SensingOmega-3 fatty acids had some beneficial effects on serum adiponectin levels, insulin resistance and lipid profile in PCOS patients and may contribute to the improvement of metabolic complications in these patients.23017309
LossDeregulated Nutrient SensingLoss continues into old age (24 months) and is inversely correlated with the development of insulin resistance.23020201
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingGender distribution of risk factors showed that hypertension and dyslipidemia are major risk factors in group 1.23022901
DyslipidemiasDeregulated Nutrient SensingTotal cholesterol, low-density lipoprotein cholesterol and triglycerides decreased to near-optimal values in dyslipidaemia patients.23023902
Liver carcinoma, Liver neoplasmsDeregulated Nutrient SensingSIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas.23024800
NeoplasmsDeregulated Nutrient SensingThe increased expression of SIRT1 has recently been identified in numerous human tumors and a possible correlation with c-Myc oncogene has been proposed.23024800
NeoplasmsDeregulated Nutrient SensingHowever, it remains unclear whether SIRT1 functions as an oncogene or tumor suppressor.23024800
Malignant neoplasm of liver, Liver carcinomaDeregulated Nutrient SensingWe sought to elucidate the role of SIRT1 in liver cancer under the influence of c-Myc and to determine the prognostic significance of SIRT1 and c-Myc expression in human hepatocellular carcinoma.23024800
Malignant neoplasm of liverDeregulated Nutrient SensingThe effect of either over-expression or knock down of SIRT1 on cell proliferation and survival was evaluated in both mouse and human liver cancer cells.23024800
Liver carcinomaDeregulated Nutrient SensingThe prognostic significance of the immunohistochemical detection of SIRT1 and c-Myc was evaluated in 154 hepatocellular carcinoma patients.23024800
Liver neoplasmsDeregulated Nutrient SensingSIRT1 and c-Myc regulate each other via a positive feedback loop and act synergistically to promote hepatocellular proliferation in both mice and human liver tumor cells.23024800
Liver carcinomaDeregulated Nutrient SensingIn human hepatocellular carcinoma, SIRT1 expression positively correlated with c-Myc, Ki67 and p53 expression, as well as high a-fetoprotein level.23024800
Liver carcinomaDeregulated Nutrient SensingMoreover, the expression of SIRT1, c-Myc and p53 were independent prognostic indicators of hepatocellular carcinoma.23024800
Neoplastic Cell TransformationDeregulated Nutrient SensingIn conclusion, this study demonstrates that SIRT1 expression supports liver tumorigenesis and is closely correlated with oncogenic c-MYC expression.23024800
Liver carcinomaDeregulated Nutrient SensingIn addition, both SIRT1 and c-Myc may be useful prognostic indicators of hepatocellular carcinoma and SIRT1 targeted therapy may be beneficial in the treatment of hepatocellular carcinoma.23024800
Proteinuria, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThey also had a higher prevalence of hypertension (P = .001), dyslipidemia (P = .004) and proteinuria (P = .001).23026595
ObesityDeregulated Nutrient SensingParathyroid hormone and insulin resistance in distinct phenotypes of severe obesity: a cross-sectional analysis in middle-aged men and premenopausal women.23027922
Units Of Measure - SiemensDeregulated Nutrient SensingMHO (n = 43) and IRO (n = 86) subjects were identified according to quartiles of insulin resistance.23027922
Demographics Domain, Seizures, Dyslipidemias, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingCo-morbid DM with SZ predicted worse overall cognitive performance and lower scores for three cognitive domains (vigilance, processing speed, and reasoning), but none of the other metabolic factors (i.e., obesity, hypertension and dyslipidemia) correlated with cognitive function in SZ.23031192
Heart Diseases, Endothelial dysfunctionDeregulated Nutrient SensingInsulin resistance (IR) and endothelial dysfunction are frequently associated in cardiac disease.23031426
ObesityDeregulated Nutrient SensingCorrection for variables of obesity and insulin resistance almost completely abrogated this difference in endocannabinoids.23032139
Inflammation, Sleep Apnea, CTCAE, ObesityDeregulated Nutrient SensingIn multivariate regression analysis, anandamide was a stronger determinant of blood pressure than sleep apnea severity, obesity, insulin resistance, and inflammation.23032139
Weight decreased, Diabetes MellitusDeregulated Nutrient SensingThe glycemic response to gastric bypass is related to BMI, duration of diabetes, fasting C-peptide (influenced by insulin resistance and residual b-cell function), and weight loss.23033249
Malignant neoplasm of endometriumDeregulated Nutrient SensingCase-control study of markers of insulin resistance and endometrial cancer risk.23033315
Primary malignant neoplasm, Malignant neoplasm of endometrium, ObesityDeregulated Nutrient SensingThis population-based study provides evidence for a role of insulin resistance in endometrial cancer etiology and may provide one possible pathway whereby obesity increases the risk of this common cancer.23033315
Malignant neoplasm of endometrium, ObesityDeregulated Nutrient SensingInterventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk.23033315
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingHematopoietic cell transplantation (HCT) recipients may be at an increased risk of developing hypertension, diabetes, and dyslipidemia (referred to as cardiovascular risk factors [CVRFs]); and these factors can potentially increase the risk of cardiovascular disease (CVD).23034279
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHistory of grade II-IV acute graft versus host disease was associated with an increased risk for hypertension (relative risk [RR] = 9.1, P < .01), diabetes (RR = 5.8, P < .01), and dyslipidemia (RR = 3.2, P < .01); conditioning with total body irradiation was associated with an increased risk of diabetes (RR = 1.5, P = .01) and dyslipidemia (RR = 1.4, P < .01).23034279
Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance and the risk of stroke and stroke subtypes in the nondiabetic elderly.23035021
Diabetes Mellitus, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance, which plays a key role in the development of diabetes mellitus, is a putative modifiable risk factor for stroke.23035021
Cerebrovascular accidentDeregulated Nutrient SensingCox regression was used to determine associations between insulin resistance markers and stroke risk, adjusted for age, sex, and potential confounders.23035021
Cerebrovascular accidentDeregulated Nutrient SensingIn conclusion, in this population-based cohort study among nondiabetic elderly, insulin resistance markers were not associated with risk of stroke or any of its subtypes.23035021
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingPersonal attributes that influence the adequate management of hypertension and dyslipidemia in patients with type 2 diabetes.23035799
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia are often insufficiently controlled in persons with type 2 diabetes (T2D) in Germany.23035799
Metabolic DiseasesDeregulated Nutrient SensingInsulin resistance (IR) is a metabolic disorder that is increasing worldwide and has been associated with several negative health outcomes.23037180
Cardiovascular DiseasesDeregulated Nutrient SensingGlobal fat mass distribution seems to correlate with different levels of cardio-metabolic risk; centrally distributed fat carries a high risk of cardiovascular disease, while lower limb adiposity may have a protective effect against insulin resistance.23037332
Chronic Kidney DiseasesDeregulated Nutrient SensingThe insulin resistance observed was similar among age-, sex- and body mass index-matched individuals with and without CKD.23043683
CLU protein, human, DyslipidemiasDeregulated Nutrient SensingFurthermore, overall secondary patency rates remain within the standard limits, although preoperative CLI and dyslipidemia continue to be associated with worse outcomes.23044257
Fetal Growth RetardationDeregulated Nutrient SensingThe homozygous mutation of the IGF1R is associated with severe IUGR, dysmorphic features, and insulin resistance, while both parents were asymptomatic heterozygous carriers of the same mutation.23045302
Colorectal Carcinoma, S100A4 protein, humanDeregulated Nutrient SensingUp-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.23045412
Malignant NeoplasmsDeregulated Nutrient SensingThe expression of c-MYC and SIRT1 correlated with the presence of KRAS and BRAF mutations and high expression of c-MYC and SIRT1 was strongly associated with higher grades of malignancy.23045412
Serrated NoduleDeregulated Nutrient SensingIn contrast, in the majority of serrated lesions without KRAS or BRAF mutations, c-MYC and SIRT1 expression was not found increased.23045412
Carcinoma, Intraepithelial NeoplasiaDeregulated Nutrient SensingIn this group only a subset of mostly high grade intraepithelial neoplasia and carcinoma was characterized by elevated c-MYC and SIRT1 expression.23045412
Serrated Nodule, Colorectal Carcinoma, Malignant NeoplasmsDeregulated Nutrient SensingThe increasing expressions with higher grades of malignancy suggest crucial functions for c-MYC and SIRT1 in the progression of serrated lesions to colorectal cancer.23045412
Polycystic Ovary Syndrome, Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingWomen with polycystic ovary syndrome (PCOS) are potentially at increased risk of cardiovascular (CV) diseases due to well-established risk factors, including insulin resistance, obesity and type 2 diabetes mellitus (T2DM).23046078
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingPostprandial glucose, fasting insulin and insulin resistance were elevated in women with PCOS.23046530
Diabetes MellitusDeregulated Nutrient SensingApart from their role in cardiovascular homeostasis and immunomodulation, aldosterone and cortisol are also implicated in the pathogenesis of insulin resistance and type 2 diabetes mellitus (T2DM).23047828
Breast CarcinomaDeregulated Nutrient SensingEndocrine therapy resistance is in part mediated by insulin resistance in obese women with breast cancer.23053261
Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, Hypertension, CTCAEDeregulated Nutrient SensingA retrospective analysis of immediate outcome was performed of patients undergoing right hepatectomy and affected by two or more metabolic disorders (diabetes mellitus, hypertension, dyslipidemia, obesity/overweight) without any other known cause of liver disease from January 2001 to May 2010.23054903
Weight decreasedDeregulated Nutrient SensingLifestyle intervention improved insulin resistance, decreased ADMA, and increased ghrelin in obese subjects with IR although no significant weight loss was observed.23055013
ARCN1 gene, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIn the univariate risk analysis, COPD, hypertension, diabetes, obesity, and dyslipidemia were risk factors for ischemic heart disease.23055717
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingMitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes.23057846
Endothelial dysfunction, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim of the present study was to determine whether the endothelial dysfunction associated with CAD (coronary artery disease) and T2D (Type 2 diabetes mellitus) is concomitant with elevated mtROS (mitochondrial reactive oxygen species) production in the endothelium and establish if this, in turn, regulates the activity of endothelial AMPK (AMP-activated protein kinase).23057846
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLevels of mitochondrial H(2)O(2) and activity of AMPK were significantly elevated in primary HSVECs (human saphenous vein endothelial cells) from patients with CAD and T2D compared with those from patients with CAD alone.23057846
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncubation with the mitochondria-targeted antioxidant, MitoQ(10) significantly reduced AMPK activity in HSVECs from patients with CAD and T2D but not in cells from patients with CAD alone.23057846
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingElevated mtROS production in the endothelium of patients with CAD and T2D increases AMPK activation, supporting a role for the kinase in defence against oxidative stress.23057846
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFurther investigation is required to determine whether pharmacological activators of AMPK will prove beneficial in the attenuation of endothelial dysfunction in patients with CAD and T2D.23057846
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo evaluate the impact on glycemic control, insulin secretion and on insulin resistance of a sitagliptin + metformin combination compared to metformin monotherapy in type 2 diabetic, naive to treatment, patients.23061989
Depression, CTCAEDeregulated Nutrient SensingIn addition, patients with depression have insulin resistance during testing tolerance to insulin, and during testing tolerance to glucose.23062454
Hyperglycemia, Critical IllnessDeregulated Nutrient SensingCritically ill patients often experience high levels of insulin resistance and stress-induced hyperglycemia, which may negatively impact outcomes.23063028
Inflammation, Heart failureDeregulated Nutrient SensingAlthough plasma palmitoleic acid has been positively associated with blood pressure, inflammation, and insulin resistance, its association with heart failure has not been investigated.23065037
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe elevated fetuin-A levels could have a clinical implication in the increased cardiovascular risk and insulin resistance associated with NAFLD and IGT.23066121
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, AtherosclerosisDeregulated Nutrient SensingThe liver-secreted protein fetuin-A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis.23067229
Apolipoproteins BDeregulated Nutrient SensingThe CR group also showed a significant decrease in apolipoprotein B, leptin and insulin resistance compared to those in the control group, although endothelial function was not different.23067229
Vascular DiseasesDeregulated Nutrient SensingThe independent role of insulin resistance (IR) and high fasting blood glucose (FBG) levels within the normal range on vascular diseases is still under debate.23067236
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOf the 52 patients, 61.5% had hypertension and 59.6% had dyslipidemia.23068107
Hyperglycemia, Cardiac complication, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe improvement after surgery in hyperglycemia, hypertension, and dyslipidemia could help in controlling the occurrence of micro- and macrovascular complications and decrease the morbidity and mortality associated with T2DM.23068107
Glucose Intolerance (disease), Gonadotropin deficiency, Cardiomyopathies, ArthropathyDeregulated Nutrient SensingHe had no signs of cardiomyopathy, gonadal insufficiency, arthropathy, or glucose intolerance.23069304
AtrophicDeregulated Nutrient SensingInsulin resistance, brain atrophy, and cognitive performance in late middle-aged adults.23069842
Alzheimers DiseaseDeregulated Nutrient SensingInsulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease.23069842
Alzheimers DiseaseDeregulated Nutrient SensingInsulin resistance may play a role in Alzheimer disease etiopathogenesis.23069842
Temporal LobeDeregulated Nutrient SensingA region-of-interest analysis, independent of the voxel-wise analyses, confirmed that higher insulin resistance was related to medial temporal lobe atrophy.23069842
Temporal LobeDeregulated Nutrient SensingTemporal lobe atrophy that was predicted by higher insulin resistance significantly mediated worse RAVLT encoding performance.23069842
Alzheimers Disease", AtrophicDeregulated Nutrient SensingThese results suggest that insulin resistance in an asymptomatic, late middle-aged cohort is associated with progressive atrophy in regions affected by early Alzheimer disease.23069842
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPoor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation.23070058
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDecreased SIRT1 protein levels were observed in EPCs from type 2 diabetic patients compared with control individuals (p < 0.01).23070058
Hyperglycemia, Peripheral vascular complication, Diabetes MellitusDeregulated Nutrient SensingThese findings unveil a link between PAF and SIRT1 pathways in EPCs that contributes to the deleterious effect of hyperglycaemia on the functional properties of EPCs, crucial in diabetes and peripheral vascular complications.23070058
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Haiti, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with type 2 diabetes mellitus (T2DM) frequently have other common diseases such as hypertension (HT), dyslipidemia (DL), and cardiovascular disease (CVD).23073638
Metabolic Diseases, Dyslipidemias, ObesityDeregulated Nutrient SensingPresent-day SK diseases are often accompanied with marked systemic metabolic disorders (obesity, dyslipidemia, androgen deficiency).23074925
Dyslipidemias, Chronic Kidney Diseases, ObesityDeregulated Nutrient SensingWe believe that early detection and pathogenetic correction of dyslipidemia, obesity and androgen deficiency in SK men may be key prophylactic factors of SK diseases which often entail development of chronic renal failure.23074925
Dyslipidemias, Cardiovascular Abnormalities, AtherosclerosisDeregulated Nutrient SensingCONCLUSIONS--The study revealed an increased risk of cardiovascular abnormalities and an increased risk of atherosclerosis: 65,61% subjects were obese, 90,6% with high blood pressure, 62,5% had dyslipidaemia.23077929
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin-like growth factor-1 (IGF-1) is involved in the pathogenesis of insulin resistance (IR) and T2D.23078161
Complication Aspects, Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, LipodystrophyDeregulated Nutrient SensingHIV-positive patients receiving combination antiretroviral therapy (cART) frequently experience metabolic complications such as dyslipidemia and insulin resistance, as well as lipodystrophy, increasing the risk of cardiovascular disease (CVD) and diabetes mellitus (DM).23078769
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingShort sleep duration is associated with hypertension and diabetes; however, its association with dyslipidemia is not well known.23081691
Dyslipidemias, Osage languageDeregulated Nutrient SensingPercent sleep time of oxygen saturation as measured by pulse oximetry (SpO2) < 90% and prevalence of severe OSA were greater and sleep duration and mean SpO2 during sleep were lower in subjects with dyslipidemia than in those without.23081691
ObesityDeregulated Nutrient SensingRaised levels of circulating LPS can trigger an increase in chronic pro-inflammatory cytokines, which may mediate the development of insulin resistance and obesity.23082944
Dyslipidemias, OverweightDeregulated Nutrient SensingAlmost 80% of PCI patients were overweight (body mass index >=25 kg/m(2)), 80% had dyslipidemia, and 27.6% were current or recent smokers.23083784
Diabetes MellitusDeregulated Nutrient SensingThe association of fatty acid composition with insulin resistance and type 2 diabetes has been reported in Western populations, but there is limited evidence of this association among the Japanese, whose populace consume large amounts of fish.23084639
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFinally, 2 months of therapy with the antidiabetic drug metformin significantly inhibited the maturation of IL-1b in MDMs from patients with type 2 diabetes through AMP-activated protein kinase (AMPK) activation.23086037
diabeticDeregulated Nutrient SensingTherefore, we evaluated its effect on insulin sensitivity since there is a quest for studies that focus at better understanding of insulin resistance aspects in diabetic patients.23088514
diabeticDeregulated Nutrient SensingThe supplementation used decreased insulin resistance in type 2 diabetic patients, suggesting a positive action in blood glucose control as adjuvant therapy in conventional treatments.23088514
Tumor necrosisDeregulated Nutrient SensingInsulin resistance, C-reactive protein, tumour necrosis factor a, and interleukin 6 decreased across omega-3 PUFA tertiles among the Health 2000 survey participants.23089109
Arterial Stiffness, Carotid Artery PlaqueDeregulated Nutrient SensingAmong the Fishermen study men, insulin resistance and arterial stiffness indicated by b-stiffness index tended to increase and the RR estimate for carotid artery plaque tended to decrease across tertiles of PCDD/F+PCB and MeHg.23089109
Obesity, AtherosclerosisDeregulated Nutrient SensingElevated PAI-1 concentrations have been implicated in the pathogenesis of such aging-related conditions as insulin resistance, obesity, and atherosclerosis.23089338
Dyslipidemias, Obesity, Hypertensive disease, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is associated with obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM).23089926
Dyslipidemias, OsteoporosisDeregulated Nutrient SensingWomen reported being more likely to eat healthy, but also were more likely to have a physician diagnosis of high blood pressure, dyslipidemia, osteoporosis and overall poor health status.23090310
Diabetes Mellitus, Non-Insulin-Dependent, Beta-Cell Function MeasurementDeregulated Nutrient SensingContribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population.23090577
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity is the major determinant of type 2 diabetes (T2D), presumably through its effect on insulin resistance.23090577
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingGenetic predisposition to obesity contributes to increased insulin resistance and to its compensation through increased b-cell function, and weakly increases the T2D risk.23090577
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingAdipose tissue is an active endocrine organ that secretes various metabolically important substances including adipokines, which represent a link between insulin resistance and nonalcoholic steatohepatitis (NASH).23091808
Impaired T cell functionDeregulated Nutrient SensingIn conclusion, common variation in MAP4K4 is associated with insulin resistance and b-cell dysfunction, possibly via this gene's role in inflammatory signalling.23094072
Metabolic Diseases, Dyslipidemias, ObesityDeregulated Nutrient SensingThe most common metabolic disorders were: obesity (68% in men with TT levels >350 ng/dL and 91% in men with TT levels <350 ng/dL) and dyslipidemia (54 and 95%, respectively).23094956
Dyslipidemias, ObesityDeregulated Nutrient SensingTestosterone deficiency was very common in population of Polish men presenting with EDs and correlated negatively with age, obesity and dyslipidemia.23094956
Apolipoprotein E, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingHigh serum apolipoprotein E determines hypertriglyceridemic dyslipidemias, coronary disease and apoA-I dysfunctionality.23096223
Apolipoprotein E, DyslipidemiasDeregulated Nutrient SensingThe relevance of serum apolipoprotein E (apoE) levels to two hypertriglyceridemic dyslipidemias has not been clarified.23096223
Dyslipidemias, Diabetes Mellitus, Lipodystrophy, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingDyslipidemia, hypertension, diabetes mellitus and renal failure were the most frequent conditions; 17 pts (14%) had clinical lipodystrophy secondary to TAR.23096476
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMS was classified according to International Diabetes Federation (2007) and the presence of dyslipidemia according to Back et al.23097084
Inflammation, Observation Method - Coagulation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of physical activity with insulin resistance, subclinical inflammation, coagulation, and fibrinolytic biomarkers among population at high risk for type 2 diabetes.23101283
Inflammation, Observation Method - Coagulation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTO investigate the association of physical activity with insulin resistance and biomarkers of inflammation, coagulation, and fibrinolysis in a population at high risk for type 2 diabetes.23101283
InflammationDeregulated Nutrient SensingPhysical activity was independently associated with insulin resistance and biomarkers of inflammation, whereas only a tendency towards decreased concentrations of coagulation and fibrinolytic biomarkers with increasing physical activity was observed.23101283
Triglycerides, ETV3 wt AlleleDeregulated Nutrient SensingOur results suggest that insulin resistance may be independently associated with MetS, large waist circumference, high triglycerides, and low HDL-C only among girls.23107107
Weight decreasedDeregulated Nutrient SensingInsulin resistance predicts the effectiveness of different glycemic index diets on weight loss in non-obese women.23108147
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn addition, hypertension, smoking, diabetes mellitus, and dyslipidemia were more prevalent among patients with significant CAD (P<0.05).23108183
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere were high incidence rates of hypertension (20%), diabetes mellitus (11%), dyslipidemia (38%), and smoking (34%).23108720
CerebrovascularDeregulated Nutrient SensingAssociation of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: the J-SHIP and Toon Health Study.23109550
With intensityDeregulated Nutrient SensingConversely, low hematocrit was a significant risk factor for periventricular hyperintensity independent of insulin resistance.23109550
Steatohepatitis, ObesityDeregulated Nutrient SensingLow IGF-I levels have been associated with obesity, insulin resistance, hepatic steatosis, and were shown to predict cardiovascular mortality.23111188
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe five most frequent conditions in men (median age 47 years) were dyslipidaemia (81.2%), hypertension (54.4%), low HDLc (41.1%), elevated triglycerides (32.3%) and elevated non-HDLc (26.8%).23111762
CNTNAP1 protein, human, Hypertension, CTCAE, IFNG wt Allele, DyslipidemiasDeregulated Nutrient SensingManidipine seems to ameliorate the possible statin-associated increase in insulin resistance as compared with olmesartan in patients with IFG, hypertension, and mixed dyslipidemia.23113965
Hyperinsulinism, Ischemic strokeDeregulated Nutrient SensingHyperinsulinaemia and insulin resistance are involved in the pathogenesis of ischaemic stroke.23115066
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHaving a diagnosis of diabetes or dyslipidemia was significantly associated with greater monitoring rates.23117285
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe aim of this study was to determine the association of exposure to LAN in an uncontrolled home setting with melatonin secretion, obesity, dyslipidemia, and diabetes.23118419
Dyslipidemias, ObesityDeregulated Nutrient SensingFurthermore, LAN exposure is associated with higher odds ratios (ORs) for obesity (body mass index: OR, 1.89; P = 0.02; abdominal: OR, 1.62; P = 0.04) and dyslipidemia (OR, 1.72; P = 0.02) independent of demographic and socioeconomic parameters.23118419
Dyslipidemias, ObesityDeregulated Nutrient SensingMoreover, LAN exposure is associated with higher ORs for obesity and dyslipidemia independent of demographic and socioeconomic parameters.23118419
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingElevated serum level of retinol-binding protein 4 (RBP4) has been associated with obesity-related co-morbidities including insulin resistance, dyslipidemia and hypertension.23119072
Diabetic Nephropathy, Diabetes Mellitus, Non-Insulin-Dependent, OsteoporosisDeregulated Nutrient SensingThe relationship between insulin resistance and osteoporosis in elderly male type 2 diabetes mellitus and diabetic nephropathy.23122575
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingPaediatric type III dyslipidaemia: a case of vanishing hyperlipidaemia.23125303
Hepatitis CDeregulated Nutrient Sensing[Insulin resistance disturbances in patients with HCV infection].23131982
Hepatitis CDeregulated Nutrient SensingThe aim of investigation was to study the impact of insulin resistance in patients with HCV infection.23131982
Diabetes MellitusDeregulated Nutrient SensingThe interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.23133645
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing1542 samples (692 T2D patients and 850 controls) were sequenced for the 1.46 kb region upstream the translation start site of the SIRT1 gene.23133645
Choroidal NeovascularizationDeregulated Nutrient SensingThe purpose of this study was to evaluate the potential role of SIRT1 in the pathogenesis of choroidal neovascularization in age-related macular degeneration.23135526
Dyslipidemias, ObesityDeregulated Nutrient SensingNeck circumference was found to be a powerful indicator of atherogenic dyslipidaemia above and beyond central obesity indicators.23135790
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingThe proportion of donors with obesity increased from 8% to 26% and with glucose intolerance from 9% to 25%.23137211
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe prevalence of Dyslipidemia, overweight and obesity were 88%, 48.7% and 18.7% respectively.23139960
Hyperglycemia, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, hyperglycemia, dyslipidemia and obesity are prevalent among our diabetic patients.23139960
Malignant neoplasm of endometriumDeregulated Nutrient Sensing[Serum changes of adiponectin, insulin resistance and their correlation in endometrial cancer patients].23141290
Malignant neoplasm of endometriumDeregulated Nutrient SensingTo explore changes of serum adiponectin and insulin resistance in patients with endometrial cancer and to evaluate the clinical significance and correlation.23141290
Endometrial CarcinomaDeregulated Nutrient SensingAdiponectin reducing and insulin resistance in reproductive age patients may be the independent factors to promote endometrial cancers.23141290
Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIn multivariate analysis, NAFLD was independently associated with being Mexican-American (including Hispanic or other ethnicity), larger waist circumference (cm), type-2 diabetes, insulin resistance and hypertension.23143735
Microalbuminuria, Glucose Intolerance (disease)Deregulated Nutrient SensingHigh urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria.23144053
Cardiac complication, hepcidinDeregulated Nutrient SensingDue to recently discovered pleiotropic effects of hepcidin, this may worsen insulin resistance and contribute to the cardiovascular complications of MetS.23144745
ObesityDeregulated Nutrient SensingSerum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults.23144966
ObesityDeregulated Nutrient SensingSerum FABP1 correlates positively with obesity and insulin resistance in Chinese young adults.23144966
TG gene, DyslipidemiasDeregulated Nutrient SensingA significant correlation was observed between resting pulse rate and TC (r = 0.102, P = 0.001), TG (r = 0.182, P = 0.001), and dyslipidemia (r = 0.037, P = 0.008).23145157
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingIn the multivariate models, the adjusted odds ratios for hypercholesterolemia (from 1.07 to 1.15), hypertriglyceridemia (1.11 to 1.16), low HDL hypercholesterolemia (1.03 to 1.06), high LDL hypercholesterolemia (0.92 to 1.14), and dyslipidemia (1.04 to 1.07) were positively increased across quartiles of resting pulse rate (P for trend <0.05).23145157
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe ROC curve indicated that resting pulse rate had low sensitivity (78.95%, 74.18%, 51.54%, 44.39%, and 54.22%), specificity (55.88%, 59.46%, 57.27%, 65.02%, and 60.56%), and the area under ROC curve (0.70, 0.69, 0.54, 0.56, and 0.58) for identifying the risk of hypercholesterolemia, hypertriglyceridemia, low HDL hypercholesterolemia, high LDL hypercholesterolemia, and dyslipidemia, respectively.23145157
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFrequent eye examination should be undertaken in patients having underlying risk factors like diabetes, hypertension or dyslipidemia undergoing interferon therapy.23146860
Fatty degenerationDeregulated Nutrient SensingPatients with steatosis had decreased phosphorylation of the insulin kinase AKT1, mediating insulin receptor signaling, and the transcription factor FOXO1, which was therefore more active mediating insulin resistance at transcriptional level.23147115
Liver damage, Fatty degeneration, DyslipidemiasDeregulated Nutrient SensingIRS2 expression was correlated with the severity of steatosis, dyslipidemia and liver damage.23147115
Obesity, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPhysical inactivity, arterial hypertension, dyslipidemia, obesity, and diabetes mellitus increased with age.23150649
Glucose Intolerance (disease), Obesity, AbdominalDeregulated Nutrient SensingThe overall prevalence of glucose intolerance was 3.7% but was higher in girls compared with boys (4.2% vs. 3.2%, P<0.001) and increased to 12.7% in girls with abdominal obesity.23151017
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingEducational inequalities in the distribution of CVRF were larger in women than in men for alcohol consumption, obesity, hypertension and dyslipidemia (p<0.05).23152909
Arterial StiffnessDeregulated Nutrient SensingDecreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, traditional cardiovascular risk factors and insulin resistance have all been associated with increased arterial stiffness.23153108
ERBB3 wt Allele, THM gene, Non-Small Cell Lung Carcinoma, Acute Erythroblastic LeukemiaDeregulated Nutrient SensingPathway activation mapping of NSCLC revealed distinct subgroups composed of epidermal growth factor receptor (ERBB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3), v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4), v-akt murine thymoma viral oncogene homolog 1- mammalian target of rapamycin (AKT-mTOR), protein kinase, AMP-activated, alpha 2 catalytic subunit (AMPK), and autophagy-related signaling, along with transforming growth factor-beta-signaling protein 1 (SMAD), insulin-line growth factor receptor (IGFR), rearranged during transfection proto-oncogene (RET), and activated CDC42-associated kinase (ACK) activation.23154546
Hypertension, CTCAEDeregulated Nutrient SensingOn the 75 g OGTT, 50 mg Losartan with 12.5 mg HCTZ combinations did not worsen glucose tolerance; moreover, they improved BP, insulin resistance and sensitivity in non-DM Japanese patients with essential hypertension uncontrolled with ARBs alone.23154622
TG gene, DyslipidemiasDeregulated Nutrient SensingInformation about subjects' history of dyslipidemia, treatment and control were collected by face-to-face interview; and each subject's fasting venous blood was drawn in the morning before having food, to test total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C).23157860
Acute Coronary SyndromeDeregulated Nutrient Sensing[The association of insulin resistance, blood pressure variability and severity of acute coronary syndrome].23158858
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingROC curve analysis in diabetes, hypertension, dyslipidemia and multivariate logistic regression analysis were also conducted.23158916
Microalbuminuria, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingEight patients (45%) had hypertension, while dyslipidemia and microalbuminuria was present in 7 patients (39%) each.23158974
Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD).23159207
Diabetes MellitusDeregulated Nutrient SensingFurther adjustment for diabetes mellitus or insulin resistance, protection against which has been proposed to mediate the beneficial relationships of adiponectin with outcome, attenuated the association in the lower range.23159554
ObesityDeregulated Nutrient SensingIncreased serum osteocalcin levels were accompanied by a decreasing trend in all anthropometric indices of obesity, systolic blood pressure, blood glucose, insulin resistance index, triglycerides, free fatty acid, and C-reactive protein levels (all P < 0.05).23162093
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is a chronic and complex disease that is characterized by impaired insulin resistance and dysregulated immune response.23163570
Dyslipidemias, ETV3 wt AlleleDeregulated Nutrient SensingAmong MetS determinants, only dyslipidaemia (increased serum triglycerides and reduced serum high-density lipoprotein) was associated with an increased risk of having a prostatic volume >60 cm(3) (hazard ratio (HR) = 3.268, P < 0.001).23165431
Steatohepatitis, Dyslipidemias, Overweight, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo verify potential risk factors associated with hepatic steatosis, such as: alcohol consumption, overweight, dyslipidemia, hypertension, and type 2 diabetes mellitus.23165584
DyslipidemiasDeregulated Nutrient SensingElevated levels of intact parathyroid hormone (iPTH) may play an important role in the pathogenesis of the dyslipidemia in hemodialysis (HD) patients, but the underlying mechanisms are not clearly defined.23168847
DyslipidemiasDeregulated Nutrient SensingThese findings suggest that iPTH most probably does not play a significant role in the dyslipidemia of renal failure.23168847
Adrenal incidentaloma, Cushing Syndrome, Dyslipidemias, Saint Helena Islands, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Spinal FracturesDeregulated Nutrient SensingThe possible different prevalence of arterial hypertension (AH), type 2 diabetes mellitus (T2DM), dyslipidaemia (DL) and vertebral fractures (FX) between patients with bilateral and unilateral adrenal incidentalomas (BAI and UAI, respectively) with and without subclinical hypercortisolism (SH) is unknown.23169694
HypercholesterolemiaDeregulated Nutrient SensingThe combination of colesevelam with rosuvastatin 5 mg/day may be associated with favorable effects on markers of insulin resistance compared with rosuvastatin 10 mg/day in patients with hypercholesterolemia and IFG.23170931
Inflammation, Corneal Endothelial Cell LossDeregulated Nutrient SensingThe aim of our study was to determine whether plasma levels of oxLDL/b2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/b2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin.23171597
Obesity, AbdominalDeregulated Nutrient SensingIn summary, oxLDL/b2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study.23171597
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn addition to its close association with Type 2 diabetes, which reduces life expectancy in older people, age-related insulin resistance is implicated in pathogenesis of several highly prevalent disorders for which ageing is a major risk factor.23173973
ObesityDeregulated Nutrient SensingThe rapidly rising number of older people, coupled with a high prevalence of insulin resistance resulting from obesity and sedentary lifestyles, presents unprecedented public health and societal challenges.23173973
InflammationDeregulated Nutrient SensingVitamin D deficiency is associated with risk for a first cardiovascular event in the general population, possibly because of inflammation, insulin resistance, and neurohumoral activation.23174181
myocardial injuryDeregulated Nutrient SensingImpact of insulin resistance on post-procedural myocardial injury and clinical outcomes in patients who underwent elective coronary interventions with drug-eluting stents.23174640
myocardial injuryDeregulated Nutrient SensingThese results indicated the impact of insulin resistance on post-procedural myocardial injury and clinical outcome after elective PCI with drug-eluting stent deployment.23174640
macroangiopathy, Low-Density Lipoproteins, Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingCD36 may play an important role in removal of oxidized LDLs from plasma, protein glycation, the pathogenesis of insulin resistance, type 2 diabetes, and diabetic micro- and macroangiopathy.23175350
Hyperglycemia, Dyslipidemias, Inflammation, Prediabetes syndromeDeregulated Nutrient SensingPioglitazone slowed progression of CIMT, independent of improvement in hyperglycemia, insulin resistance, dyslipidemia, and systemic inflammation in prediabetes.23175674
Hepatobiliary Disorder, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAlthough impaired synthesis and/or bioavailability of nitric oxide are considered to contribute to insulin resistance and the progression of liver disease in nonalcoholic fatty liver disease, role of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, has not been examined.23179302
Endothelial dysfunctionDeregulated Nutrient SensingEndothelial dysfunction (flow-mediated dilation, FMD), hsCRP and insulin resistance were determined.23180042
Endothelial dysfunctionDeregulated Nutrient SensingWe also looked at how NLR and its individual components change across CKD stages and whether NLR is related to CRP, insulin resistance and endothelial dysfunction.23180042
Weight Gain, Non-alcoholic Fatty Liver Disease, Epilepsy, Fatty Liver DiseaseDeregulated Nutrient SensingValproic acid (VPA), as one of the most widely prescribed antiepileptic drugs (AED) for many types of epilepsy in adults and children, is associated with weight gain, alteration of adipocytokine homeostasis, insulin resistance and Non-Alcoholic Fatty Liver Disease (NAFLD).23182413
Non-alcoholic Fatty Liver Disease, Obesity, Visceral, Diabetes MellitusDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4) and Glucagon-like peptide-1 (GLP-1) are considered as important new targets in modern type 2 diabetes mellitus therapy linked to insulin resistance, NAFLD and visceral obesity acting via peripheral or central mechanisms.23182413
Depressive disorderDeregulated Nutrient SensingPlasma fatty acid profile in depressive disorder resembles insulin resistance state.23183516
Depressive disorderDeregulated Nutrient SensingThe aim of the study was to investigate the composition of FA in plasma cholesterol esters (CE) and phosphatidylcholine (PC) as well as indices of insulin resistance and oxidative stress in the patients with depressive disorder.23183516
Bipolar DisorderDeregulated Nutrient SensingEsterified FA composition of depressive patients revealed changes, similar to those, usually observed in insulin resistance.23183516
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia contributes substantially to the residual cardiovascular risk.23183517
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingPeripheral insulin resistance in type 1 diabetes may be related to a paradoxical postprandial glucagon increase.23186950
Hyperlipidemia, Cardiomyopathies, Liver Dysfunction, Obesity, Hypogonadism, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlstrom syndrome is a rare disorder typified by early childhood obesity, neurosensory deficits, cardiomyopathy, progressive renal and hepatic dysfunction, and endocrinological features such as severe insulin resistance, type 2 diabetes, hyperlipidemia, and hypogonadism.23188138
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingMultivariate logistic regression analysis identified a medical history of dyslipidemia as an independent predictor for chronic kidney disease manifested postoperatively.23190329
Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingOur results show that high-flux dialyzers improved dyslipidemia and endothelial dysfunction in hemodialysis patients.23190521
Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingThe APOM polymorphism as a novel risk factor for dyslipidaemia in rheumatoid arthritis: a possible shared link between disease susceptibility and dyslipidaemia.23190940
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingWe investigated the possible association between an APOM polymorphism and dyslipidaemia in Korean RA patients.23190940
Dyslipidemias, DiseaseDeregulated Nutrient SensingSubgroup analyses according to disease activity showed that the association between APOM genotype and HDL cholesterol levels was still significant in all subgroups, indicating that this APOM polymorphism may increase the dyslipidaemia risk, independently of RA disease activity.23190940
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThese data support that the APOM C-1065A polymorphism is associated with increased risk for developing RA and dyslipidaemia in RA patients.23190940
Refractory anemias, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThese findings suggest that a specific genetic factor for RA could be linked to dyslipidaemia and this could increase the risk of atherosclerosis in RA patients.23190940
Sarcopenia, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance (IR), which is highly prevalent in patients receiving CHD, has been proposed to play a critical role in the development of sarcopenia.23194840
Sarcopenia, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance represents a potential mechanism for sarcopenia commonly observed in patients receiving CHD.23194840
ETV3 wt Allele, Dyslipidemias, Ventricular dilatation (disorder), Hypertension, CTCAEDeregulated Nutrient SensingThe MetS group (n = 229) had higher incidence of hypertension, dyslipidemia, and ventricular dilatation than the non-MetS group (n = 256).23196975
Anxiety, CTCAE 3.0, Obesity, Abdominal, Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingLongitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity.23197842
Anxiety, CTCAE 3.0, Obesity, Abdominal, Depression, CTCAE, DyslipidemiasDeregulated Nutrient SensingPrevious research indicates that patients with severe symptoms of depression or anxiety are prone toward the development of dyslipidemia and abdominal obesity.23197842
Dyslipidemias, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingTherefore, such people are at elongated and increasing risk for dyslipidemia and obesity, predisposing them to cardiovascular disease.23197842
Hypertension, CTCAE, diabetic, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe studied 216 patients who attended our diabetic center with diagnoses of diabetes, hypertension and/or dyslipidemia.23198531
Diabetes MellitusDeregulated Nutrient SensingThe important role of raised serum gamma-glutamyl transferase (GGT) for predicting diabetes mellitus and insulin resistance is clear; however relationship between increased level of GGT and impaired glucose tolerance (IGT) is now hypothesized.23199536
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Ventricular hypertrophyDeregulated Nutrient SensingThe most common CV risk factors included left ventricular hypertrophy (72% of patients), abdominal obesity (54%), dyslipidemia (48%), family history of early CV events (33%), smoking (24%), and type 2 diabetes (21%).23203238
urinary, Diabetes MellitusDeregulated Nutrient SensingUrinary iodine is associated with insulin resistance in subjects with diabetes mellitus type 2.23203253
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingC-peptide is a proinsulin cleavage product released from the pancreas in amounts equimolar to insulin, and elevated levels of C-peptide have been found in patients with insulin resistance and early type 2 diabetes mellitus.23204248
Apolipoproteins B, nialamideDeregulated Nutrient SensingSubjects with EIH presented higher waist circumference (WC) (P<0.01), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB) levels as well as insulin resistance (all P<0.05).23205504
Inflammation, ObesityDeregulated Nutrient SensingThe increased S100A9 reported for obesity and insulin resistance may be envisioned as a compensatory mechanism for inflammation.23207880
Inflammation, Kidney Failure, Chronic Kidney DiseasesDeregulated Nutrient SensingPatients with chronic kidney disease (CKD) are likely to have low levels of 25(OH)D, and recent observations have linked suboptimal vitamin D status with adverse cardiovascular outcomes, inflammation, insulin resistance, and the rate of progression of renal insufficiency.23209039
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingIncreases in dyslipidemia and abdominal obesity contributed to the increased prevalence in Korea, whereas in the United States, decreases in low high-density lipoprotein cholesterolemia and high blood pressure contributed to a decreased prevalence.23209102
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is an underlying cause of metabolic changes associated with cardiovascular diseases.23212335
Diabetes MellitusDeregulated Nutrient SensingWhen patients with diabetes mellitus were compared to patients without insulin resistance, significantly lower levels of GRa mRNA were observed in epicardial fat.23212335
Rheumatoid ArthritisDeregulated Nutrient SensingIncreased toll-like receptor 2 expression in peptidoglycan-treated blood monocytes is associated with insulin resistance in patients with nondiabetic rheumatoid arthritis.23213270
Refractory anemiasDeregulated Nutrient SensingThe close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study.23213270
Refractory anemiasDeregulated Nutrient SensingAccordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients.23213270
NeoplasmsDeregulated Nutrient SensingNovel (nua) kinase family 1 (NUAK1) is a member of the human adenosine monophosphate (AMP)-activated protein kinase family that has been identified as a key tumor cell survival factor.23215946
Demographics Domain, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingGly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD).23216712
Cockayne SyndromeDeregulated Nutrient SensingResveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria.23217256
ProgeriaDeregulated Nutrient SensingThe link between conserved SIRT1 longevity pathway and progeria suggests a stem cell-based and SIRT1 pathway-dependent therapeutic strategy for progeria.23217256
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia and hypertension are the major risk factors contributing to cardiovascular disease (CVD).23217598
Dyslipidemias, Complications of Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingBased on these data the annual prevalences of dyslipidemia and hypertension were calculated and patients were stratified by age, gender, and diabetic complications.23217598
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn patients with diabetes, the prevalence of dyslipidemia increased with age, with the highest rate recorded in adults (inclusive of both genders) between 40 and 65 years of age (p for trend <0.001).23217598
Disorder of eye, Dyslipidemias, Kidney Diseases, diabeticDeregulated Nutrient SensingThe prevalence of dyslipidemia increased in diabetic patients with eye diseases and in men with nephropathies, but decreased in women with nephropathies during the study period.23217598
Cerebrovascular Disorders, Dyslipidemias, Cerebrovascular accident, Cardiac complication, Peripheral Vascular DiseasesDeregulated Nutrient SensingIn contrast, the prevalence of dyslipidemia decreased in patients with macrovascular complications, including CVD and cerebrovascular disease (cerebrovascular accident), but increased in those patients with PVD (p for all trends <0.05).23217598
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Cerebrovascular accident, Hypertension, CTCAEDeregulated Nutrient SensingAlthough progressively increased prevalence of dyslipidemia and hypertension was observed in patients with diabetes in Taiwan, there was a decrease in the prevalence of stroke and CVD in the past 10 years.23217598
Peripheral Vascular Diseases, Vascular Diseases, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAmong those with macrovascular diseases, except PVD, there was a trend of decreased prevalence of hypertension and dyslipidemia during the study period.23217598
Dyslipidemias, Microvascular Angina, Hypertension, CTCAE, Disorder of eyeDeregulated Nutrient SensingIn patients with microvascular diseases, prevalence of hypertension and dyslipidemia in patients with eye diseases increased in the past 10 years.23217598
Liver Cirrhosis, Fatty Liver DiseaseDeregulated Nutrient SensingIncreases in body mass index and fluctuations in transaminase levels, as well as the evaluation of homeostatic model assessment-insulin resistance, ferritin, and hyaluronic acid in F3 stage NASH patients may prove useful in identifying individuals at risk of progression to cirrhosis.23221052
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingBMI, prevalence of central obesity, homeostatic model assessment index of insulin resistance, plasma triglycerides, fibrinogen, and CRP increased progressively across categories of glucose intolerance (P < 0.0001), with the IFG+IGT group having higher values than those with isolated IFG (0.05 < P < 0.0001).23223343
AtherosclerosisDeregulated Nutrient SensingHowever, the direct role of SIRT1 in atherosclerosis and how SIRT1 in VSMCs might regulate atherosclerosis are unknown.23224247
atheroscleroticDeregulated Nutrient SensingSIRT1 expression was reduced in human atherosclerotic plaques and VSMCs both derived from plaques and undergoing replicative senescence.23224247
Low-Density LipoproteinsDeregulated Nutrient SensingVSMCs from mice expressing inactive truncated SIRT1 (Dex4) showed increased oxidized low-density lipoprotein-induced DNA damage and senescence.23224247
AtherosclerosisDeregulated Nutrient SensingApoE(-/-) mice expressing SIRT1(Dex4) only in smooth muscle cells demonstrated increased DNA damage response activation and apoptosis, increased atherosclerosis, reduced relative fibrous cap thickness, and medial degeneration.23224247
AtherosclerosisDeregulated Nutrient SensingSIRT1 is reduced in human atherosclerosis and is a critical regulator of the DNA damage response and survival in VSMCs.23224247
Medial degeneration, AtherosclerosisDeregulated Nutrient SensingVSMC SIRT1 protects against DNA damage, medial degeneration, and atherosclerosis.23224247
AtherosclerosisDeregulated Nutrient SensingVascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis.23224247
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn both genders, such overestimation was predicted by dyslipidemia, a lower waist circumference, a higher level of perceived fitness, and no exercise intention; also (among men) by a higher age and a family history of diabetes, and (among women) by a lower occupational status, and a lower BMI.23224617
Dyslipidemias, HaitiDeregulated Nutrient SensingIn addition, there were gender and aging differences in % smoking, % HT, BMI and eGFR, whereas no differences were observed in % DM, % dyslipidemia or % HU.23224925
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingDiabetes, pre-diabetes and insulin resistance screening in Native American children and youth.23229738
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingEarly identification of pre-diabetes and insulin resistance (IR) provides an important window of opportunity for diabetes prevention.23229738
Bipolar DisorderDeregulated Nutrient SensingGlycemia, insulin resistance, insulin secretion, and risk of depressive symptoms in middle age.23230097
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance, hallmarks of type 2 diabetes mellitus.23232064
Dyslipidemias, diabeticDeregulated Nutrient SensingUse of a performance measure that credits appropriate clinical action indicates that almost 85% of diabetic veterans 50 to 75 years of age are receiving appropriate dyslipidemia management.23233749
ETV3 wt AlleleDeregulated Nutrient SensingThis study demonstrates that seasonal variation in MetS prevalence is associated with mildly to moderately increased insulin resistance in middle-aged Japanese men.23235713
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingAs the case detection rate of arterial hypertension increases daily in rural Nigeria, screening for its associated abdominal obesity and dyslipidemia is an important healthcare challenge.23238199
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingOf great concern in rural Nigeria is that most geriatric hypertensives with abdominal obesity and dyslipidemia are not routinely diagnosed and therefore do not receive appropriate management.23238199
DyslipidemiasDeregulated Nutrient SensingFifty-four (44.3%) out of 122 patients had at least one dyslipidemia with the most frequent being low high-density lipoprotein cholesterol (HDL-C, 38.5%).23238199
Obesity, Abdominal, Antihypertensive Agents, DyslipidemiasDeregulated Nutrient SensingThis study has shown that abdominal adiposity and dyslipidemia exist among geriatric hypertensives in the study area with abdominal obesity being the most common abdominal adiposity and low HDL-C being the most frequent lipid abnormality.23238199
Dyslipidemias, Obesity, Abdominal, Antihypertensive AgentsDeregulated Nutrient SensingThis study therefore urges the necessity to consider abdominal obesity and dyslipidemia in geriatric hypertensives in rural Nigeria alongside the complex of other cardiovascular risk factors.23238199
Muscle (organ)Deregulated Nutrient SensingInsulin signal transduction was competent up to p-Akt activation; however, p-adenosine monophosphate-activated protein kinase (p-AMPK) was not detectable in CIM muscle.23239154
AtrophicDeregulated Nutrient SensingElectrical muscle stimulation increased p-AMPK, repositioned GLUT4, locally improved glucose metabolism, and prevented type-2 fiber atrophy.23239154
Muscle Contraction, Failure (biologic function)Deregulated Nutrient SensingEvoked muscle contraction may prevent muscle-specific AMPK failure, restore GLUT4 disposition, and diminish protein breakdown.23239154
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingLow-density lipoprotein cholesterol (LDL-C) remains the primary target of therapy in most strategies of dyslipidaemia management focused on cardiovascular disease prevention.23241052
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes and dyslipidaemia increased with age and body mass index.23241053
Presenile dementia, "Alzheimers Disease", Impaired cognition, Data types - AddressDeregulated Nutrient SensingInsulin resistance increases the risk of cognitive impairment and dementia, but higher insulin levels may be cognitively protective after a diagnosis of Alzheimer's disease (AD).23241558
Inflammation, Pancreatic carcinomaDeregulated Nutrient SensingAlthough development of pancreatic cancer is associated with states of insulin resistance and chronic inflammation, the mechanistic basis of the associations is poorly understood.23243202
Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingPlasma adiponectin was inversely associated with pancreatic cancer risk, which was consistent across the five prospective cohorts (P (heterogeneity) = .49) and independent of other markers of insulin resistance (eg, diabetes, body mass index, physical activity, plasma C-peptide).23243202
Inflammation, SLC5A8 wt AlleleDeregulated Nutrient SensingThe numbers of attacks and of individuals with attacks were examined in conjunction with endothelial function, oxidative stress, inflammation, and insulin resistance before and after 3 successive days of AIT.23249633
Inflammation, SLC5A8 wt Allele, Angina Pectoris, VariantDeregulated Nutrient SensingAIT in the afternoon suppressed the attacks in conjunction with improvement in endothelial function, oxidative stress, inflammation, and insulin resistance in patients with coronary spastic angina.23249633
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingAmong individuals without type 2 diabetes, similar effect modification was observed by obesity and insulin resistance.23250801
Diabetes MellitusDeregulated Nutrient SensingThe association of fetuin-A with risk of CVD differs among elderly individuals with and without insulin resistance or type 2 diabetes.23250801
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is one of the important modifiable risk factors for cardiovascular disease.23251338
Diabetes MellitusDeregulated Nutrient SensingThere is recent interest surrounding the use of the triglyceride-to-HDL cholesterol ratio as a surrogate marker of insulin resistance in clinical practice, as it may identify people at high risk of developing diabetes or its complications.23251403
Dyslipidemias, Chronic Obstructive Airway Disease, Hypertension, CTCAE, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingThe patient was affected by arterial hypertension, dyslipidaemia, severe chronic obstructive pulmonary disease, and recurrent atrial fibrillation.23253549
Coronary Artery Disease, diabeticDeregulated Nutrient SensingWe hypothesised, that perioperative use of N(2)-L-alanyl-L-glutamine confers cardioprotection and improves insulin resistance in diabetic patients with coronary artery disease operated under cardiopulmonary bypass.23253886
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingEffect of bezafibrate on office, home and ambulatory blood pressure in hypertensive patients with dyslipidemia.23254592
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingWe investigated the effects of bezafibrate on office, home and ambulatory BP in hypertensive patients with dyslipidemia.23254592
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingIn conclusion, bezafibrate improved lipid metabolism and insulin sensitivity but did not affect office, home or ambulatory BP in hypertensive patients with dyslipidemia.23254592
TG gene, DyslipidemiasDeregulated Nutrient SensingA decreased risk was also found with high TG levels which may depend on genetic vulnerability to dyslipidemia related to APOA5.23254630
Primary malignant neoplasmDeregulated Nutrient SensingHere we discuss how these p53-mTORC1 interactions might play a role in the suppression of cancer and perhaps the development of cellular senescence and organismal aging.23255104
Primary malignant neoplasmDeregulated Nutrient SensingAnalysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.23255128
Primary malignant neoplasmDeregulated Nutrient SensingWhile SIRT1 exerts beneficial effects in protecting against age-related diseases, the role of SIRT1 in cancer has been controversial.23255128
NeoplasmsDeregulated Nutrient SensingSIRT1 promotes cell survival by deacetylating, and thereby negatively regulating the activity of important tumor suppressors such as p53.23255128
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingIn contrast, it has been shown that SIRT1 deficiency leads to increased genomic instability and tumorigenesis, and that overexpression of SIRT1 attenuates cancer formation in mice, suggesting it may also act as a tumor suppressor.23255128
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingIn order to gain insight into the role of SIRT1 in cancer, we performed a comprehensive resequencing analysis of the SIRT1 gene in 41 tumor cell lines and found an unusually excessive homozygosity, which was confirmed to be allelic loss by microsatellite analysis.23255128
NeoplasmsDeregulated Nutrient SensingWe conclude that allelic loss or mutations in the SIRT1 gene occur prevalently during tumorigenesis, supporting the assertion that SIRT1 may serve as a tumor suppressor.23255128
Damage, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage.23255852
ARCN1 geneDeregulated Nutrient SensingUnexpectedly, calcineurin expression was higher, while phospho-AMPK was lower, in COPD patients with fibre shift compared to COPD patients without fibre shift.23258787
ARCN1 geneDeregulated Nutrient SensingReduced phospho-AMPK may contribute to reduced quadriceps oxidative capacity and endurance in COPD.23258787
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThe prevalence of hypertension, Type 2 diabetes and dyslipidaemia was 45.6, 13.3 and 41.7%, respectively.23258806
Dyslipidemias, Diabetes Mellitus, Obesity, Haiti, Hypertensive (finding)Deregulated Nutrient SensingThe prevalence of cardiovascular risk factors in hypertensive women (HT) with respect to non-hypertensive women (NHT) was as follows: obesity 44.7 versus 18.9%, dyslipidaemia 48.8 versus 35.8% and Type 2 diabetes 21.8 versus 6.1%.23258806
Hyperparathyroidism, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and secondary hyperparathyroidism were not accounted for in the analysis.23260275
Inflammation, Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingThis study identifies possible mediators of the effect of SEAD on myocardial infarction, because SEAD is associated with a lower concentration of markers of inflammation and with reduced triglycerides, insulin, insulin resistance, and systolic blood pressure.23261168
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingSpecific constellations of lipoprotein particle features, reflected as differences in mean lipoprotein particle diameters, are associated with risk of insulin resistance (IR) and cardiovascular disease (CVD).23263444
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingPeople infected with HIV have a higher risk for developing insulin resistance, diabetes, and cardiovascular disease than the general population.23264399
MyocardiumDeregulated Nutrient SensingWhether this may be attributed to the insulin resistance of cardiac muscle has to be further investigated.23264539
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingRisk reductions for cardiovascular disease with pravastatin treatment by dyslipidemia phenotype: a post hoc analysis of the MEGA Study.23265677
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSignificant risk reductions were observed for CHD by 38% (p=0.04) and CVD by 31% (p=0.02) in type IIa dyslipidemia but not in phenotype IIb.23265677
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingPravastatin therapy provided significant risk reductions for CHD and CVD in patients with phenotype IIa dyslipidemia, but not in those with phenotype IIb dyslipidemia.23265677
ObesityDeregulated Nutrient SensingPredictors of insulin resistance in patients with obesity: a pilot study.23267236
diabeticDeregulated Nutrient SensingThe p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study.23269546
diabeticDeregulated Nutrient SensingOur findings suggest that p53 codon 72 (Arg72Pro) polymorphism influences insulin resistance in type 2 diabetic patients independently of body mass.23269546
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCarbohydrate nutrition differs by diabetes status and is associated with dyslipidemia in Boston Puerto Rican adults without diabetes.23269655
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingInstead, the levels of total cholesterol (TC), TG, LDL-C, and the prevalence of dyslipidemia were significantly higher in the three Bama families as compared to the two non-Bama families (P < 0.01 for all).23273182
Increased insulin level, Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingZinc-a2-glycoprotein is associated with insulin resistance in humans and is regulated by hyperglycemia, hyperinsulinemia, or liraglutide administration: cross-sectional and interventional studies in normal subjects, insulin-resistant subjects, and subjects with newly diagnosed diabetes.23275352
Diabetes Mellitus, Non-Insulin-Dependent, Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingSerum ZAG (determined with ELISA) was compared with various parameters related to insulin resistance in subjects with normal glucose tolerance, impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM), and in women with or without polycystic ovary syndrome (PCOS).23275352
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGrape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.23275372
Infertility, DyslipidemiasDeregulated Nutrient SensingRelationship between dyslipidaemia and semen quality and serum sex hormone levels: an infertility study of 167 Japanese patients.23278423
Cortical malformationsDeregulated Nutrient SensingTransfection of E6 into fetal mouse brains caused a focal cortical malformation in association with enhanced mTORC1 signaling.23280839
Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingThe crude HR of developing ACS for the DM group compared to the non-DM group was 1.333 (95% confidence interval [95% CI] 1.236-1.439, P < 0.0001), whereas the adjusted HR was 1.321 (95% CI 1.224-1.425, P < 0.0001) after adjustment for age, sex, and dyslipidemia.23281342
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingEven though previous studies have demonstrated that thyroid hormone replacement therapy (THRT) improves cardiac function and dyslipidemia in patients with SCH, it remains unclear as to whether THRT can improve renal function in CKD patients with SCH.23281965
Obesity, Diabetes MellitusDeregulated Nutrient SensingAdiponectin has antidiabetic properties, and patients with obesity, diabetes, and insulin resistance have low plasma adiponectin levels.23283133
Kidney Failure, Chronic, Kidney DiseasesDeregulated Nutrient SensingHowever, although kidney disease is associated with insulin resistance, adiponectin is elevated in end-stage renal disease.23283133
Hypertensive (finding)Deregulated Nutrient SensingWe studied the characteristics of insulin resistance in 19 normotensive and 25 hypertensive subjects who underwent an acute protocol for determination of salt-sensitivity of blood pressure.23283360
diabeticDeregulated Nutrient SensingAngiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation.23283553
diabeticDeregulated Nutrient SensingEx vivo SIRT1 activation restored EOC chemokine secretion and increased the in vitro and in vivo angiogenic activity of EOC conditioned medium derived from diabetic animals to levels similar to that derived from control animals.23283553
physiopathologicalDeregulated Nutrient SensingThese findings suggest a pivotal role for SIRT1 in diabetes-induced EOC dysfunction and that its pharmacologic activation may provide a new strategy for the restoration of EOC-mediated repair mechanisms.23283553
Sleep Apnea Syndromes, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSleep apnoea syndrome and 10-year cardiovascular risk in females with type 2 diabetes: relationship with insulin secretion and insulin resistance.23283827
Inflammation, Sleep Apnea Syndromes, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingSleep apnoea, a frequent comorbidity of T2DM women, is associated with central fat, atherogenic dyslipidaemia, inflammation, worsening b-cell function, poorer glycaemic control and coronary artery disease risk.23283827
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingModel 2 showed more randomly distributed residuals in patients with diabetes, atherogenic dyslipidemia, and those taking lipid-lowering agents than model 1.23284722
ObesityDeregulated Nutrient SensingInsulin resistance was diagnosed in 76% of the patients with morbid obesity (56.2% in grade II obesity and 51.4 in grade I obesity vs. 15.2% in controls).23285761
Heart Diseases, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe participants were married, with low education levels, family history of heart diseases, arterial hypertension, dyslipidemia, and a sedentary lifestyle.23288183
LipolysisDeregulated Nutrient SensingAblation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.23291629
ObesityDeregulated Nutrient SensingTRIP-Br2-null mice are resistant to obesity and obesity-related insulin resistance.23291629
Hyperlipidemia, ObesityDeregulated Nutrient SensingThese data, together with the observation that TRIP-Br2 expression is selectively elevated in visceral fat in obese humans, suggests that this transcriptional co-regulator is a new therapeutic target for counteracting the development of obesity, insulin resistance and hyperlipidemia.23291629
Psoriasis, ObesityDeregulated Nutrient SensingPsoriasis is associated with obesity accompanied by insulin resistance.23291856
TG gene, DyslipidemiasDeregulated Nutrient SensingCoA can effectively reduce plasma TG levels in subjects with moderate dyslipidemia and has no obvious adverse effect.23293333
Peripheral Vascular Diseases, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHigher leucocyte levels were associated with dyslipidaemia, smoking, peripheral arterial disease, stroke severity, and lesion size.23295074
Inflammation, Diabetes MellitusDeregulated Nutrient SensingIn recent years, evidence has emerged indicating that insulin resistance and diabetes mellitus type 2 are associated with inflammation of adipose tissue (AT).23296264
Malignant neoplasm of urinary bladder, Inflammation, Obesity, Abdominal, Diabetes MellitusDeregulated Nutrient SensingWe also observed a synergistic interaction between diabetes and high WHR in bladder cancer development that might be explained by increased insulin resistance and inflammation related to abdominal obesity.23296458
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIncreasing prevalence of obesity has been associated with concomitant increases in childhood hypertension, dyslipidaemia and type 2 diabetes.23296459
Diabetes MellitusDeregulated Nutrient SensingDue to the possible mechanism of insulin resistance which is associated with impaired insulin receptors after HSCT procedure, metformin with insulin appears to be effective in the treatment of this type of diabetes.23296512
Diabetes MellitusDeregulated Nutrient SensingAssociation between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk.23298335
Diabetes Mellitus, Chronic inflammatory disorderDeregulated Nutrient SensingThese results show that dietary phylloquinone intake is associated with an improvement of cytokines and other markers related to insulin resistance and diabetes, thus extending the potential protection by dietary phylloquinone on chronic inflammatory diseases.23298335
Dyslipidemias, HIV-1 Infection Pathway, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with dyslipidemia associated with HIV-1 infection and highly active antiretroviral therapy (HAART) have elevated levels of Lp-PLA2 and CCL5/regulated on activation, normal T-cell expressed and secreted (RANTES), which may increase the risk of cardiovascular disease.23299761
DyslipidemiasDeregulated Nutrient SensingElevated plasma Lp-PLA2 mass can be reduced by an intensive D/E program in patients with HIV/HAART-associated dyslipidemia.23299761
Primary malignant neoplasm, Dyslipidemias, Diabetic Angiopathies, Thyroid Diseases, Chronic Obstructive Airway Disease, Hypertension, CTCAEDeregulated Nutrient SensingFurthermore, patients with benign thyroid disease or other cancer, living in Kao-Ping/Eastern regions, or receiving potential detection examinations might have a significantly higher risk; and male sex, hypertension, dyslipidemia, chronic obstructive pulmonary disease, vascular complications or use of statin, aspirin or non-steroidal anti-inflammatory drugs might be associated with a significantly lower risk.23300866
Pancreatitis, Dyslipidemias, Biliary calculiDeregulated Nutrient SensingAlcoholism and gallstones were associated with a large increase in the risk of acute pancreatitis (adjusted odds ratio 13.40 and 14.29, respectively, P<0.001), although dyslipidemia was associated with significant risk reduction (adjusted odds ratio 0.62, P<0.001).23300896
Myeloid Leukemia, ChronicDeregulated Nutrient SensingIn healthy term infants, high dietary load with CML does not play a pathophysiological role in the induction of infant formula-associated insulin resistance.23301020
Malignant Pleural MesotheliomaDeregulated Nutrient SensingPARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1.23301673
KeloidDeregulated Nutrient SensingTreatment with either KU-0063794 or KU-0068650 resulted in complete suppression of Akt, mTORC1, and mTORC2, and inhibition of keloid cell spreading, proliferation, migration, and invasive properties at a very low concentration (2.5 mmol l(-1)).23303455
Left Ventricular Hypertrophy, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe same analysis revealed that the combination of impaired glucose level, abdominal obesity, and dyslipidemia was associated with LV hypertrophy only in women.23303723
Diastolic dysfunction, DyslipidemiasDeregulated Nutrient SensingThe combination of increased BP, fasting glucose, and dyslipidemia was independently associated with LV diastolic dysfunction only in women.23303723
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe magnitude of atherogenic dyslipidaemia among geriatric Nigerians with systemic hypertension in a rural hospital in Eastern Nigeria.23304929
Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingThe relevance of dyslipidaemia in the management of cardiovascular diseases, especially hypertension is an important health care challenge that is increasing worldwide.23304929
Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingOf great concern in Nigeria is that most geriatric hypertensives with dyslipidaemia are not routinely diagnosed and therefore do not receive appropriate treatment.23304929
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was defined using the third report of National Cholesterol Education Panel in adult (ATP III).23304929
DyslipidemiasDeregulated Nutrient SensingFifty-four (44.3%) out of 122 patients had at least one dyslipidaemia.23304929
Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingThis study has shown that dyslipidaemia exist among geriatric hypertensives in the study area with low HDL-C being the most frequent lipid abnormality suggesting that low HDL may be the major form of dyslipidaemia and a marker of dyslipidaemic cardiometabolic risk among them.23304929
Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingScreening for dyslipidaemia should therefore form an important part of clinical care of geriatric hypertensives and those with dyslipidaemia should become target for lipid lowering treatment in addition to lifestyle modification.23304929
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIn multivariable analyses, factors independently associated with a lower risk of HAP were female gender (odds ratio [OR] 0.84), dyslipidemia (OR 0.84), and hypertension (OR 0.94).23305674
Rheumatoid ArthritisDeregulated Nutrient SensingPredictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance.23311682
Refractory anemias, Endothelial dysfunctionDeregulated Nutrient SensingHOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA.23311682
DyslipidemiasDeregulated Nutrient SensingRosuvastatin + fenofibric acid may be more efficacious than rosuvastatin alone in patients with mixed dyslipidemia.23312049
Glucose Intolerance (disease), Kidney FailureDeregulated Nutrient SensingTypically, the offspring of animals that are undernourished in pregnancy exhibit a relatively narrow range of physiological phenotypes that includes higher blood pressure, glucose intolerance, renal insufficiency and increased adiposity.23312451
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAtorvastatin ameliorates podocyte injury in patients with type 2 diabetes complicated with dyslipidemia.23312613
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingAlthough coronary heart disease in users of combined oral contraceptives (COCs) is rare, one of the principal risk factors for its occurrence is dyslipidemia.23312931
Increased insulin level, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease.23316320
DyslipidemiasDeregulated Nutrient SensingAdipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia.23316323
Apolipoproteins B, Lipolysis, Dyslipidemias, HypertriglyceridemiaDeregulated Nutrient SensingInappropriate storage of fatty acids as triglycerides in adipocytes and their removal from adipocytes through lipolysis and subsequent oxidation may cause the atherogenic dyslipidemia phenotype of elevated apolipoprotein B levels and subsequent hypertriglyceridemia.23316323
DyslipidemiasDeregulated Nutrient SensingThis suggests a hitherto unknown role of triglyceride turnover in adipocytes for the development and/or maintenance of atherogenic dyslipidemia.23316323
Diabetes MellitusDeregulated Nutrient SensingLipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study.23320821
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes (T2D), there are limited data available regarding the relationship of LPL and 25(OH)D to IR and T2D at a population level.23320821
Leukemia, Myelocytic, AcuteDeregulated Nutrient SensingThe mTORC1 signaling pathway is constitutively activated in almost all acute myelogenous leukemia (AML) patients.23321953
Diabetes MellitusDeregulated Nutrient SensingIf ucOC plays a similar role in humans, then antiresorptive therapies, which reduce ucOC levels, may increase the risk of insulin resistance and diabetes.23322676
TG gene, DyslipidemiasDeregulated Nutrient SensingThe most prevalent dyslipidemias in Mexico are low high-density lipoprotein (HDL) and high triglyceride (TG) levels.23323877
Primary malignant neoplasm, Dyslipidemias, Hyponatremia, Diabetes Mellitus, Congestive heart failure, Hypertension, CTCAE, Liver CirrhosisDeregulated Nutrient SensingHyponatremia remained significantly associated with mortality after adjustment for age, gender, ethnicity, diabetes, hypertension, dyslipidemia, smoking, alcohol use, renal function, plasma C-reactive protein, use of antiepileptic drugs and selective serotonin reuptake inhibitors, and history of congestive heart failure, cirrhosis, and cancer (hazard ratio of 1.75).23325088
Carotid Intima-Media ThicknessDeregulated Nutrient SensingAssociation of insulin resistance indexes to carotid intima-media thickness.23326550
Blood Vessel, Carotid Intima-Media Thickness, Cardiovascular DiseasesDeregulated Nutrient SensingAccumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima-media thickness (IMT), an indicator of vascular damage.23326550
Sleep Apnea, Obstructive, Hypoxia, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingObstructive sleep apnea is a risk factor for dyslipidemia and atherosclerosis, which have been attributed to chronic intermittent hypoxia (CIH).23328524
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingTo examine whether CIH induces dyslipidemia and atherosclerosis by increasing adipose Angptl4 via hypoxia-inducible factor-1 (HIF-1).23328524
NeoplasmsDeregulated Nutrient SensingSIRT1 has also been shown to be involved in multiple tumors.23332867
Interstitial tissue of prostate, Skeletal muscle structureDeregulated Nutrient SensingIn nonneoplastic tissue, strong cytoplasmic SIRT1 reactivity was observed in all prostate stroma, smooth muscle, and striated muscle.23332867
NeoplasmsDeregulated Nutrient SensingAlthough the physiologic role of SIRT1 remains to be clarified in myoid tissues and neoplasms differentiating along these lines, this observation points to a potential role for this marker in diagnostic immunohistochemistry.23332867
NeoplasmsDeregulated Nutrient SensingAdditional studies are necessary to further characterise the role of SIRT1 in myoid tissues and neoplasms.23332867
Weight decreasedDeregulated Nutrient SensingGenetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet.23333123
Inflammation, ObesityDeregulated Nutrient SensingWe previously demonstrated that angiopoietin-like protein 2 (Angptl2), a pro-inflammatory factor secreted by adipose tissue, promotes adipose tissue inflammation and subsequent systemic insulin resistance in obesity.23333801
Prostate Cancer Outcomes Study, Glucose Intolerance (disease)Deregulated Nutrient SensingOf 252 patients with PCOS, 41 had glucose intolerance (IGT 14.3%; T2DM 2%) when compared with 10 of the 117 control patients (IGT 8.5%; T2DM 0%; odds ratios = 2.08; P = 0.045) during the OGTT.23335611
Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient Sensing[Prevalence of dyslipidemia and elevated cardiovascular risk in patients with rheumatoid arthritis].23335702
Glucose Intolerance (disease), IGHD1-7 gene, Diabetes MellitusDeregulated Nutrient SensingPNP was somewhat more frequent in DM1 patients with glucose intolerance and diabetes mellitus (66.7 vs. 33.7%, P = 0.05).23336676
Demyelination, Diabetes Mellitus, Glucose Intolerance (disease), Thyroid dysfunction, IGHD1-7 geneDeregulated Nutrient SensingIn DM1 patients with no glucose intolerance, diabetes mellitus and thyroid dysfunction, the most frequent type of PNP was demyelinating (70.0%) and motor (83.3%).23336676
Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingSmoking (82%), hypertension (40%), and diabetes (30%) were the most common risk factors; ischemic heart disease (4%), obesity (2%), and dyslipidemia (3%) were rare.23336851
Autosomal Recessive Disorder, Familial generalized lipodystrophyDeregulated Nutrient SensingBerardinelli-Seip congenital lipodystrophy (BSCL) syndrome is an autosomal recessive disorder, caused by mutation in the AGPAT2 gene, which could lead to insulin resistance and variety of complications.23337016
Malignant NeoplasmsDeregulated Nutrient SensingSIRT1 is purposed to promote longevity and to suppress the initiation of some cancers.23339189
NeoplasmsDeregulated Nutrient SensingNevertheless, SIRT1 is reported to function as a tumor suppressor as well as an oncogenic protein.23339189
Liver carcinoma, Neoplasms, FAM126A geneDeregulated Nutrient SensingOur data show that compared with normal liver or surrounding tumor tissue, SIRT1 is strongly overexpressed in human hepatocellular carcinoma (HCC).23339189
FAM126A geneDeregulated Nutrient SensingIn addition, human HCC cell lines (Hep3B, HepG2, HuH7, HLE, HLF, HepKK1, skHep1) were screened for the expression of the sirtuin family members and only SIRT1 was consistently overexpressed compared with normal hepatocytes.23339189
FAM126A geneDeregulated Nutrient SensingTo determine its effect on HCC growth, SIRT1 activity was inhibited either with lentiviruses expressing short hairpin RNAs or with the small molecule inhibitor, cambinol.23339189
NeoplasmsDeregulated Nutrient SensingIn an orthotopic xenograft model, knockdown of SIRT1 resulted in 50% fewer animals developing tumors and cambinol treatment resulted in an overall lower tumor burden.23339189
Neoplasms, FAM126A geneDeregulated Nutrient SensingTaken together, our data show that inhibition of SIRT1 in HCC cells impairs their proliferation in vitro and tumor formation in vivo.23339189
FAM126A geneDeregulated Nutrient SensingThese data suggest that SIRT1 expression positively influences the growth of HCC and support further studies aimed to block its activity alone or in combination as a novel treatment strategy.23339189
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing20/(fasting C-peptide x fasting plasma glucose) is a simple and effective index of insulin resistance in patients with type 2 diabetes mellitus: a preliminary report.23339473
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe developed a simple and new insulin resistance index derived from a glucose clamp and a meal tolerance test (MTT) in Japanese patients with type 2 diabetes mellitus.23339473
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing20/(F-CPR x FPG) is a simple and effective index of insulin resistance, and performs better than HOMA-IR and ISI in Japanese patients with type 2 diabetes mellitus.23339473
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFirst Nations people with diabetes, hypertension, or dyslipidemia who were referred to the clinic.23341675
SLC25A20 geneDeregulated Nutrient SensingThe objective of this study was to evaluate the relationship between insulin resistance and the presence of coronary artery calcium (CAC) to identify risk factors that may predispose young men and women to CVD.23341938
SLC25A20 geneDeregulated Nutrient SensingFinally, after adjustment for traditional CVD risk factors, insulin resistance remained an independent predictor of CAC only in men (p = 0.03).23341938
SLC25A20 geneDeregulated Nutrient SensingUnlike men, insulin resistance was not a predictor of CAC in women in this cohort.23341938
SLC25A20 geneDeregulated Nutrient SensingTherefore, insulin resistance has less impact on CVD risk and CAC in young women compared with men, and insulin resistance alone does not explain the gender disparity in CVD risk that is observed at an early age.23341938
Impaired T cell functionDeregulated Nutrient SensingHigh-fat diet is associated with obesity-mediated insulin resistance and b-cell dysfunction in Mexican Americans.23343677
Impaired T cell function, ObesityDeregulated Nutrient SensingConsumption of energy-dense, nutrient-poor foods has contributed to the rising incidence of obesity and may underlie insulin resistance and b-cell dysfunction.23343677
Impaired T cell functionDeregulated Nutrient SensingThese findings suggest that high-fat diets may contribute to increased adiposity and concomitant insulin resistance and b-cell dysfunction in Mexican Americans.23343677
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMuscle insulin resistance, one of the earliest defects associated with type 2 diabetes, involves changes in the phosphoinositide 3-kinase/Akt network.23344726
ObesityDeregulated Nutrient SensingThe relative contribution of obesity vs insulin resistance to perturbations in this pathway is poorly understood.23344726
AtherosclerosisDeregulated Nutrient SensingThe association of alanine aminotransferase within the normal and mildly elevated range with lipoproteins and apolipoproteins: the Insulin Resistance Atherosclerosis Study.23344727
AtherosclerosisDeregulated Nutrient SensingIn this analysis we included 824 non-diabetic participants (age 40-69 years) in the Insulin Resistance Atherosclerosis Study.23344727
Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingCardiovascular disease (CVD) prevention in diabetes requires broad-based treatment of dyslipidemia, hypertension, and hyperglycemia.23345072
Extrahepatic, Glucose Intolerance (disease)Deregulated Nutrient SensingThis finding suggests that hepatic and extrahepatic insulin resistance causes or exacerbates postprandial glucose intolerance in IFG/IGT.23345093
Insulin resistance - type A, Lung Diseases, Interstitial, Autoimmune hypoglycemia, Lupus Erythematosus, SystemicDeregulated Nutrient SensingType B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease.23346003
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe significance of regular screening and aggressive treatment of other risk factors (i.e., diabetes, hypertension, and dyslipidemia) should not be overlooked.23347246
Autosomal Recessive Disorder, Rabson-Mendenhall Syndrome, RMSDeregulated Nutrient SensingRabson-Mendenhall syndrome (RMS) is an autosomal recessive disorder characterized by extreme insulin resistance and certain characteristic phenotypic features.23347304
Hypertension, CTCAE, Coronary Artery DiseaseDeregulated Nutrient SensingHeart rate and double product in relation to insulin resistance in patients with hypertension and coronary artery disease.23348533
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingElevated values of heart rate (HR) and insulin resistance (IR) reflect enhanced sympathetic nervous system activity and may be connected to the development of coronary artery disease (CAD) and diabetes.23348533
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingSirtuin 1 (SIRT1) has been implicated in telomere maintenance and the growth of hepatocellular carcinoma (HCC).23348706
Inflammation, ObesityDeregulated Nutrient SensingLow-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance.23349498
ObesityDeregulated Nutrient SensingSince glucose-dependent insulinotropic polypeptide (GIP) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate OPN expression in adipose tissue and thereby induce insulin resistance.23349498
InflammationDeregulated Nutrient SensingTogether, these data suggest a role for GIP not only as an incretin hormone but also as a trigger of inflammation and insulin resistance in adipose tissue.23349498
ObesityDeregulated Nutrient SensingBecause obesity also induces macrophage recruitment into adipose tissue, we elucidated here the role of Cbl-b in obesity-related insulin resistance.23349502
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity is an established risk factor for type 2 diabetes (T2D) and they are metabolically related through the mechanism of insulin resistance.23349771
OverweightDeregulated Nutrient SensingThe effect of leptin in obese and overweight population on insulin resistance was seldom reported.23349940
ObesityDeregulated Nutrient SensingThis may suggest that serum leptin concentration is an important predictor of insulin resistance and other metabolic risks irrespective of obesity levels.23349940
Communicable Diseases, No metabolic abnormalities, Hepatitis C, SteatohepatitisDeregulated Nutrient SensingPersistent hepatitis C virus (HCV) infection often evokes metabolic abnormalities including hepatic steatosis and insulin resistance.23351407
Steatohepatitis, Lymphoproliferative Disorder of the SkinDeregulated Nutrient SensingWe hypothesized that the relationship between the ratio of IGF-I/IGFBP-3 and the severity of hepatic steatosis or insulin resistance would be observed in patients with HCV-related chronic liver disease (CLD).23351407
Steatohepatitis, Zinc deficiencyDeregulated Nutrient SensingThese findings suggest that the decline of the circulating free IGF-I level, which derives from zinc deficiency, may contribute to hepatic steatosis and insulin resistance in patients with HCV-related CLD.23351407
OverweightDeregulated Nutrient SensingYoung overweight and obese women with lower circulating osteocalcin concentrations exhibit higher insulin resistance and concentrations of C-reactive protein.23351412
Dyslipidemias, ObesityDeregulated Nutrient SensingApoC-I and H5C levels very early in life may affect the development of dyslipidemia and obesity in childhood.23351580
Dyslipidemias, Demographics Domain, carotid disease, Diabetes MellitusDeregulated Nutrient SensingThe patients with CAD were more likely to have diabetes mellitus (DM; P = .001), dyslipidemia (P = .013), and bilateral carotid disease (P = .033).23352686
Cessation of life, GDC Comorbidity Terminology, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance is highly prevalent after stroke, contributing to comorbid cardiovascular conditions that are the leading cause of death in the stroke population.23352685
Sarcopenia, muscle massDeregulated Nutrient SensingThe myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e.23354683
Charge Type Reason - IntoleranceDeregulated Nutrient SensingThe following risk factors were found to be associated with events: male gender, coexisting diabetes/glucose intolerance and elevation of Lp(a) concentrations.23357140
Inflammation, Metabolic DiseasesDeregulated Nutrient SensingIncreased inflammation and oxidative stress are associated with insulin resistance (IR) and metabolic disorders.23361591
Skeletal muscle structureDeregulated Nutrient SensingSubjects with NWO had a lower appendicular skeletal muscle mass, a more atherogenic lipid profile and greater insulin resistance.23362933
Triglycerides, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAfter complex weighting, among elderly, the overall prevalence of hypertension was 66.9%, and the rates were greater in the eastern areas (67.9%) than in the western areas (62.5%) (P < 0.05), there was no significant difference between urban areas and rural areas (P > 0.05); the prevalence of diabetes was 19.6%, the rates were greater in the eastern areas (21.5%) than in the western areas (17.7%) (P < 0.05), and greater in the urban areas (25.0%) than in the rural areas (17.0%) (P < 0.05) ; the prevalence of high triglycerides, high blood cholesterol and high low-density lipoprotein were all higher in the urban areas (12.4%, 6.4% and 5.2%) than in the rural areas (10.1%, 4.2% and 2.8%) (all P values < 0.05), and also higher for women (12.9%, 6.9% and 4.7%) than for men (8.7%, 2.9% and 2.4%) (all P values < 0.05); the prevalence of hypertension in people with abnormal blood lipids (74.3%) was higher than those with normal blood lipids (65.7%) (P < 0.05); the prevalence of hypertension and dyslipidemia in people with diabetes (77.3%, 23.2%) were both greater than the prevalence in non-diabetic group (64.5%, 12.6%) (both P values < 0.05).23363868
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe rates of diabetes and dyslipidemia were significantly higher in the urban areas than in the rural areas.23363868
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingHowever, prospective studies investigating the relation between vitamin D inadequacy and incidence of T2D incorporating obesity and dynamic measures of insulin resistance (IR) and pancreatic b cell function are limited.23364011
Hyperglycemia, Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingObesity and overweight, hyperglycemia and dyslipidemia were the most important abnormal metabolism that related to decreased androgen indices.23368725
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn the present study, we found that serum irisin levels were decreased in T2D patients and inversely associated with newly diagnosed T2D, suggesting that irisin may play a crucial role in glucose intolerance and T2D.23369227
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingEzetimibe reduced atherogenic lipoproteins in patients with diabetes and glucose intolerance; besides, it improved glucose metabolism in patients with insulin resistance.23369229
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingEffects of ezetimibe on atherogenic lipoproteins and glucose metabolism in patients with diabetes and glucose intolerance.23369229
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingSeventy-six patients with diabetes and glucose intolerance were enrolled in this study.23369229
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is a key element in the pathogenesis of type 2 diabetes mellitus.23369247
Gestational Diabetes, Overweight, ObesityDeregulated Nutrient SensingAlthough the nature of gestational diabetes mellitus (GDM) remains unclear, the condition is thought to be related primarily to insulin resistance, overweight and obesity.23369626
Gestational DiabetesDeregulated Nutrient SensingHowever, despite normoglycaemia, women with a history of GDM were characterized by significantly impaired insulin secretion, but no signs of increased insulin resistance.23369626
SedentaryDeregulated Nutrient SensingThe occurrence of age-related diseases, therefore, reflects the synergistic interaction between our evolutionary path to sedentarism, which chronically increases a number of mTOR activating gero-promoters (e.g., food, growth factors, cytokines and insulin) and the "defective design" of central metabolic integrators such as mTOR and AMPK.23370395
TG gene, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingOur results regarding Japanese patients receiving dyslipidemia treatment for CHD prevention identified insufficient reductions in the levels of LDL-C and TG in those at high risk for CHD and suggest the need for more aggressive lipid-lowering therapy.23370735
Liver carcinoma, Hepatic impairment, Liver DysfunctionDeregulated Nutrient SensingPerioperative exercise therapy for patients with hepatocellular carcinoma with liver dysfunction may improve insulin resistance associated with hepatic impairment and suggests a benefit to the early resumption of daily exercise after hepatectomy.23374372
ObesityDeregulated Nutrient SensingAssociation of monocyte CCR2 expression with obesity and insulin resistance in postmenopausal women.23374597
ObesityDeregulated Nutrient SensingThese results provide support for significant associations of monocyte number and markers involved in monocyte activation with obesity and insulin resistance.23374597
Acanthosis NigricansDeregulated Nutrient SensingAcanthosis nigricans is a cutaneous manifestation of insulin resistance.23374951
Sepsis, HyperglycemiaDeregulated Nutrient SensingHyperglycemia and insulin resistance are commonplace in critical illness, especially in patients with sepsis.23375099
Renal Insufficiency, AtherosclerosisDeregulated Nutrient SensingA low high-density lipoprotein cholesterol, insulin resistance phenotype occurs in subjects with mild renal dysfunction and is associated with elevated monocytes and atherosclerosis.23378299
Dyslipidemias, LAURIN-SANDROW SYNDROMEDeregulated Nutrient SensingNo significant difference in the proportion of patients with dyslipidemia was apparent between the LSS and control groups.23380819
Coronary Artery DiseaseDeregulated Nutrient SensingPeripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease.23382833
AtherosclerosisDeregulated Nutrient SensingSirt1 regulates transcription factors involved in inflammatory processes and blunts atherosclerosis in mice.23382833
AtherosclerosisDeregulated Nutrient SensingThis study was therefore designed to investigate the role of Sirt1 in the development of atherosclerosis.23382833
GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingHDL from healthy subjects stimulated Sirt1 expression in THP-1 monocytes to a higher degree than HDL from CAD and ACS patients (P<0.05).23382833
GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingMonocytic Sirt1 expression is reduced in patients with stable CAD and ACS.23382833
Carcinogenic Chlorinated Hydrocarbon, Fatty degenerationDeregulated Nutrient SensingCD36 is linked to steatosis and insulin resistance in patients with G1 CHC, but does not predict response to treatment.23383656
Demographics Domain, Cardiovascular Diseases, Communicable Diseases, Ancriviroc, Hepatitis C, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingChronic hepatitis C virus (CH-C) infection is associated with metabolic conditions such as insulin resistance and type 2 diabetes (DM) and may increase the risk of cardiovascular diseases.23384408
Ancriviroc, Hypertension, CTCAEDeregulated Nutrient SensingIn multivariate analysis, in addition to known risk factors for insulin resistance, CH-C was independently associated with the presence of insulin resistance [OR (95% CI) = 2.06 (1.19-3.57)], DM [OR = 2.31 (1.18-4.54)] and hypertension [OR = 2.06 (1.30-3.24)].23384408
Hypertension, CTCAE, Hepatitis C, Diabetes Mellitus, Congestive heart failureDeregulated Nutrient SensingChronic hepatitis C virus infection is independently associated with presence of metabolic conditions (insulin resistance, type 2 diabetes mellitus and hypertension) and congestive heart failure.23384408
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingDiabetes (p<0.001), dyslipidemia (p=0.03) and obesity (p<0.001) were less prevalent in this group of patients.23385010
Abdominal aortic calcification, Diabetes Mellitus, Non-Insulin-Dependent, Stable Isotope Labeling with Amino Acids in Cell CultureDeregulated Nutrient SensingAbdominal aortic calcification (AAC) is an indicator of cardiovascular risk, especially in the diseases characterized by insulin resistance such as type 2 diabetes.23386651
TSC22D3 geneDeregulated Nutrient SensingNo difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men.23386653
Mitochondria, MuscleDeregulated Nutrient SensingIn this study we measured whether GC-induced insulin resistance in humans is related to changes in muscle ceramide, GM3, and muscle mitochondrial function.23386653
Hypertensive disease, Inflammation, DyslipidemiasDeregulated Nutrient SensingIn summary, these data suggest a complex relationship between inflammation and HTN with dyslipidemia.23388885
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingAssociation of dyslipidemia with renal outcomes in chronic kidney disease.23390545
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia with renal outcomes in patients with moderate to advanced CKD remains controversial.23390545
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingHence, our objective is to determine whether dyslipidemia is independently associated with rapid renal progression and progression to renal replacement therapy (RRT) in CKD patients.23390545
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingOur study demonstrated that certain levels of dyslipidemia were independently associated with RRT and rapid renal progression in CKD stage 3-5.23390545
Increased insulin level, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe pathophysiology of PCOS is not fully clarified, but is well established the fundamental role of the insulin resistance and the hyperinsulinemia.23390858
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe insulin resistance was improved in 80% of the PCOS patients after six months therapy with Metformin 2 x 850 mg/p.d.23390858
Diastolic blood pressure, DyslipidemiasDeregulated Nutrient SensingHowever, conventional risk factors such as smoking, dyslipidaemia, systolic and diastolic blood pressure and pulse pressure had no significant effect.23392089
Myocardial InfarctionDeregulated Nutrient SensingOnly a weak correlation was observed between the presence of subclinical myocardial necrosis and either glycemic control (r = 0.06; P = 0.044 for hemoglobin A1c versus cTnI) or insulin resistance (r = 0.04; P = 0.094 for glucose-to-insulin ratio versus cTnI).23393213
Diabetes MellitusDeregulated Nutrient SensingBlockade of receptor activator of nuclear factor-kB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus.23396210
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver.23396210
Impaired T cell functionDeregulated Nutrient SensingThere is compelling evidence that activation of the transcription factor nuclear factor-kB (NF-kB) and downstream inflammatory signaling pathways systemically and in the liver are key events in the etiology of hepatic insulin resistance and b-cell dysfunction, although the molecular mechanisms involved are incompletely understood.23396210
Adult Non-Hodgkin LymphomaDeregulated Nutrient SensingAssociation of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma.23396962
Adult Non-Hodgkin Lymphoma, RTEL1 geneDeregulated Nutrient SensingWe conducted a population-based genetic association study to examine the impact of mutations in AMPK subunit genes on risk of non-Hodgkin lymphoma (NHL).23396962
RTEL1 gene, B-Cell LymphomasDeregulated Nutrient SensingFurther, both of these subunits were differentially expressed (P < 0.05) in one or more lymphoma cell type, and higher expression of two versions of the AMPK-b subunit was significantly associated with increased 5-year survival among patients with NHL (P = 0.001 and P = 0.021).23396962
RTEL1 geneDeregulated Nutrient SensingThese results provide evidence for AMPK involvement in the pathogenesis and progression of NHL.23396962
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDietary patterns in Greenland and their relationship with type 2 diabetes mellitus and glucose intolerance.23399043
Glucose Intolerance (disease), IFNG wt AlleleDeregulated Nutrient SensingThe imported meat diet seemed the best in relation to glucose intolerance, with lowest fasting plasma glucose and lowest odds for IFG and T2DM.23399043
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingAlthough many post-mortem studies have found evidence of central insulin resistance in Alzheimer's disease (AD) patients, results on changes of central insulin-like growth factor-1 (IGF-1) signaling in the pathological process of AD remain controversial.23401344
Vascular System Injuries, Thrombus, Dyslipidemias, diabeticDeregulated Nutrient SensingThe aim of this study was to show that the connection between DM and other risk factors, such as dyslipidemia, inflammatory phenomena, or the development of certain vascular injuries, leads to a high frequency of thrombotic events in diabetic patients compared to the nondiabetic population.23401641
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Coronary Artery Disease, Heart failure, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingMajor co-existing diseases were hypertension (60.6%), heart failure (27.9%), diabetes (23.2%), stroke (19.4%), coronary artery disease (15.0%), myocardial infarction (6.4%), dyslipidemia (42.4%), and chronic kidney disease (26.4%).23403369
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingPrevious studies have suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and urinary albumin excretion rate (UAE) in normoalbuminuric patients with normal renal function.23404243
Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of obesity, diabetes, hyperglycemia, dyslipidemia, and hypertension in one such population, the Micronesian island of Kosrae was described.23404778
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingSubjects with a high BF% had a significantly higher prevalence of high blood pressure (men only), hyperglycemia, and dyslipidemia.23404833
Hyperglycemia, Primary malignant neoplasm, Diabetes MellitusDeregulated Nutrient SensingKnown associations between diabetes and cancer could logically be attributed to hyperglycemia, hypersecretion of insulin, and/or insulin resistance.23405181
Non-alcoholic Fatty Liver Disease, Obesity, AbdominalDeregulated Nutrient SensingIn subgroup analysis after multiple adjustments, significant relation between serum potassium level and prevalent NAFLD was detected in women, younger subjects, those with insulin resistance and those with central obesity, respectively.23405890
Steatohepatitis, Glucose Intolerance (disease), Hepatitis CDeregulated Nutrient SensingAmino acid substitutions in the core region associate with insulin resistance in chronic hepatitis C. Hepatitis C virus (HCV) core protein can induce liver steatosis and glucose intolerance in transgenic mice.23406967
Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, ChronicDeregulated Nutrient SensingWe aimed to clarify the association of HCV core region heterogeneity with the development of insulin resistance (IR) among patients with chronic hepatitis C (CHC).23406967
SarcopeniaDeregulated Nutrient SensingDiagnostic criteria for sarcopenia relate differently to insulin resistance.23407994
SarcopeniaDeregulated Nutrient SensingSarcopenia is, therefore, a possible risk factor for insulin resistance.23407994
Malignant Head and Neck NeoplasmDeregulated Nutrient SensingActivation of the phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in head and neck cancers, and it has been demonstrated that inhibition of mTOR complex 1 sensitizes cell lines to platinum and taxane chemotherapy.23408298
Increased insulin level, Diabetes MellitusDeregulated Nutrient SensingAbdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes.23408772
Increased insulin levelDeregulated Nutrient SensingA previously unreported, independent association between abdominal myosteatosis and hyperinsulinemia and insulin resistance among older Caucasian men was indicated.23408772
Neuropathy, Dyslipidemias, Hypertension, CTCAE, UlcerDeregulated Nutrient SensingRECOMMENDATIONSs: We recommend strengthening of routine screening for neuropathy, to emphasis on foot ulcer risk reduction, management of co-morbidities like hypertension and dyslipidemia, to optimize treatment of painful neuropathy.23409395
DyslipidemiasDeregulated Nutrient SensingRecent studies have suggested that dietary Ca may have beneficial effects on adiposity, insulin resistance, dyslipidaemia and blood pressure (BP).23411109
Obesity, Abdominal, Overweight, ObesityDeregulated Nutrient SensingSubjects in the HCG had lower OR for prevalent overweight, obesity, abdominal obesity, insulin resistance, HDL-cholesterol < 600 mg/l and systolic BP >120 mmHg.23411109
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia in chronic kidney disease in Nepalese population.23416824
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia is a potential risk factor for CVD in CKD cases.23416824
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIn this study our aim was to find out the dyslipidaemia in patients with different stages of CKD.23416824
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingCKD had a higher prevalence of dyslipidaemia compared to non-CKD controls.23416824
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia was also found in early stages of CKD.23416824
Primary malignant neoplasm, ObesityDeregulated Nutrient SensingObesity and insulin resistance are risk factors for cancer development.23418314
Pliability, Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingMitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have been implicated in the etiology of type 2 diabetes (T2D), yet their interrelationship remains speculative.23418416
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Metabolic Syndrome XDeregulated Nutrient SensingWhile nonalcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome, it is not known if NAFLD plays an independent role in the atherogenic dyslipidemia phenotype.23419204
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingIn a large, multi-ethnic, gender balanced cohort, CT-diagnosed NAFLD was associated with the atherogenic dyslipidemia phenotype in a dose dependent fashion.23419204
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingThese relationships persisted after adjustment for several metabolic risk factors and HOMA-IR, suggesting a possible independent pathophysiologic role between NAFLD and dyslipidemia.23419204
Hypertension, CTCAEDeregulated Nutrient SensingTo explore the impact of cardiac autonomic function (CAF) and insulin resistance (IR) on incident hypertension.23419733
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingThe risk for coronary heart disease according to insulin resistance with and without type 2 diabetes.23425058
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingORs for CHD increased as insulin resistance increased in both non-diabetic and diabetics.23425058
Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance was a greater risk for CHD than type 2 diabetes.23425058
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingNon-diabetics can have a higher risk for CHD than diabetics when insulin resistance is elevated.23425058
ObesityDeregulated Nutrient SensingObesity, insulin resistance, and the risk of an elevated alanine aminotransferase activity in the Korean adolescent population.23426824
ObesityDeregulated Nutrient SensingIt is unclear to what extent insulin resistance (IR) modulates the association linking obesity to alanine aminotransferase (ALT) activity elevation.23426824
Prostate carcinoma, ObesityDeregulated Nutrient SensingAndrogen-deprivation therapy (ADT) by either a gonadotropin-releasing hormone (GnRH) agonist or bilateral orchiectomy improves disease-related outcomes of men with prostate cancer but has a variety of adverse metabolic effects including obesity, increased abdominal girth, increased triglycerides, and insulin resistance.23428068
Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and dyslipidemia were more common, and the glomerular filtration rate (GFR) was significantly higher, in patients undergoing statin treatment.23430269
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn males, the risk of hypertension was significantly (95% CI 1.9, 8.7; p = 0.003) increased by 1.8-fold in the first quartile compared with the highest quartile of RBC 5-MTHF when adjusted for body mass index (BMI), age, dyslipidaemia, uric acid, creatinine, smoking, plasma tHcy and vitamin B(12).23430668
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe risk of hypertension was also significantly increased (95% CI 1.1, 9.2; p = 0.03) by 1.1-fold in the highest quartile compared with the lowest quartile of plasma tHcy when adjusted for BMI, age, dyslipidaemia, uric acid, creatinine, smoking, plasma and RBC 5-MTHF and vitamin B(12).23430668
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingRisk factors, such as hypertension, dyslipidemia, obesity and smoking play an important role in the high prevalence of NCDs.23431831
Obesity, Abdominal, Dyslipidemias, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAmong anthropometrics and imaging indices of obesity, WC and WHtR have shown better association between central obesity with dyslipidemia in the patients with CHD, while CT-measured visceral adipose tissue area was the best correlate of dyslipidemia in the patients without CHD.23432166
Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatient medical charts were used to obtain the risk factors for stroke, including diabetes, hypertension, dyslipidemia, age, and sex.23434443
Dyslipidemias, diabetic, Cardiovascular DiseasesDeregulated Nutrient SensingThis study showed obese diabetic individuals have dyslipidemia and more prone to develop cardiovascular diseases.23434961
Hypertension, CTCAEDeregulated Nutrient SensingCalcium channel blocker effect on insulin resistance and inflammatory markers in essential hypertension patients.23435396
Inflammation, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance, inflammation and oxidative stress (OS), are among the mechanisms that have been implicated in pathogenesis of essential hypertension (EH).23435396
ObesityDeregulated Nutrient SensingIrisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance.23436919
ObesityDeregulated Nutrient SensingIn men, circulating irisin levels were negatively associated with obesity and insulin resistance.23436919
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingPatients with dyslipidaemia or hypercholesterolemia carry a substantially increased cardiovascular risk and need optimal treatment of this key risk factor.23437867
Hypertriglyceridemia, Loss of facial adipose tissueDeregulated Nutrient SensingLipodystrophies are hypoleptinemic conditions characterized by fat loss, severe insulin resistance, hypertriglyceridemia, and ectopic fat accumulation.23439261
DyslipidemiasDeregulated Nutrient SensingThe MG-modified Apo A-I level may be an indicator of diabetic dyslipidemia and insulin resistance.23440769
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOdds ratios (OR) between hypertension, obesity and dyslipidemia were calculated.23441809
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe subjects were 72 patients without diabetes and cardiovascular disease being treated for hypertension or dyslipidemia.23442745
Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingIn multivariate analyses, family history of diabetes and IGF-I were associated with hyperglycaemia, BMI and IGF-I predicted insulin resistance, and age was inversely correlated with b-cell function.23446424
Dyslipidemias, Coronary Artery Disease, F3 wt Allele, Heart failureDeregulated Nutrient SensingAlthough trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF).23446892
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingTogether with a family history of dyslipidemia, the patient was diagnosed as having familial hypercholesterolemia.23448768
AtherosclerosisDeregulated Nutrient SensingImpaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the insulin resistance atherosclerosis study.23450048
AtherosclerosisDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study had a total of 1107 participants.23450048
ETV3 wt AlleleDeregulated Nutrient SensingNondiabetic individuals with pre-existing MetS risk factors were recruited for participation in the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study, a longitudinal study of the determinants of insulin resistance and MetS.23452164
ETV3 wt AlleleDeregulated Nutrient SensingMultivariate logistic regression analyses indicated a decreased risk of MetS at follow-up per standard deviation increase in baseline 25(OH)D after adjustment for sociodemographics, season, baseline and change in supplement use and physical activity and insulin resistance (OR = 0*63, 95% CI 0*44-0*90).23452164
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingSIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients.23453030
Malignant NeoplasmsDeregulated Nutrient SensingSIRT1, class III histone deacetylase, has been described to be up-regulated in various malignancies.23453030
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingTherefore, we investigated SIRT1 expression to clarify its biological behavior and identify its usefulness as a biomarker for head and neck squamous cell carcinoma (HNSCC).23453030
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingSIRT1 expression was assessed by immunohistochemistry (IHC) conducted using samples from 437 consecutive HNSCC patients.23453030
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension was reported by 65.5% of patients, diabetes by 17.9%, dyslipidemia by 58.6%, smoking by 14% and family history of coronary artery disease in 11%.23453533
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDemographic data, details on diabetes, hypertension, dyslipidemia and their treatment modalities, various risk factors and complications were updated annually.23454736
Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingComparison of plasma viscosity as a marker of endothelial dysfunction with nitric oxide and asymmetric dimethylarginine in subjects with dyslipidemia.23455843
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingPlasma viscosity, ADMA and oxLDL values were significantly higher in subjects with dyslipidemia than in subjects with normolipidemia.23455843
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance as a predictor of cardiovascular disease in patients on peritoneal dialysis.23455976
palladium, ciliary vesicleDeregulated Nutrient SensingHowever, no evaluation of the impact of insulin resistance on CV disease morbidity or mortality in patients on PD has been performed.23455976
ciliary vesicleDeregulated Nutrient SensingA multivariate Cox model was used to analyze the impact of insulin resistance on CV disease mortality.23455976
Steatohepatitis, Secondary malignant neoplasm of liver, CST9 geneDeregulated Nutrient SensingHepatic steatosis, a common condition associated with insulin resistance and excess body weight, is reported to be associated with an increased risk for perioperative mortality in patients undergoing resection of colorectal liver metastases (CLM), but its impact upon longterm survival is less well documented.23458109
Cavia, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe aim of this work was to examine whether the CAVI value in patients with dyslipidaemia (DLP) is increased by the presence of other cardiovascular risk factors: hypertension, diabetes mellitus, and smoking.23459505
Dyslipidemias, ObesityDeregulated Nutrient SensingAdditional CVD risk factors included obesity, reduced glomerular filtration rate, and dyslipidemia.23460805
Hypercholesterolemia, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes and hypertension were assessed by clinical diagnosis and dyslipidemia (high triglycerides, low HDL-cholesterol, and hypercholesterolemia) by lipid analyses.23460844
Dyslipidemias, ETV3 wt AlleleDeregulated Nutrient SensingNo significant associations were observed for the MetS components high blood pressure, dyslipidemia, or elevated fasting glucose.23460844
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIndividuals with dyslipidemia, T2DM, or hypertension tended to have a body mass index >= 25 kg/m(2).23465284
Each (qualifier value)Deregulated Nutrient SensingAmong patients with BE, increased levels of leptin and insulin resistance are associated with increased risk for EA, whereas increased levels of high-molecular-weight adiponectin is associated inversely with EA.23466711
Dyslipidemias, ObesityDeregulated Nutrient SensingThis demonstrates that chemerin levels are associated with obesity and dyslipidemia and may play a role in the development of insulin resistance.23468920
Metabolic Diseases, Hepatitis C, ChronicDeregulated Nutrient SensingInsulin resistance, serum visfatin, and adiponectin levels are associated with metabolic disorders in chronic hepatitis C virus-infected patients.23470357
Weight GainDeregulated Nutrient SensingA possible mechanism of antipsychotic-induced weight gain is activation of hypothalamic monophosphate-dependent kinase (AMPK) mediated by histamine 1 receptors.23471087
Tumor necrosis, Cardiovascular DiseasesDeregulated Nutrient SensingTumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), in addition to having a prognostic value in patients with cardiovascular disease, seems to interact with adiposity, insulin resistance and other cardiovascular risk factors.23472162
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingIdentification of a SIRT1 mutation in a family with type 1 diabetes.23473037
Autoimmune Disorder, CTCAE, Diabetes Mellitus, Insulin-Dependent, Ulcerative ColitisDeregulated Nutrient SensingHere we describe a family carrying a mutation in the SIRT1 gene, in which all five affected members developed an autoimmune disorder: four developed type 1 diabetes, and one developed ulcerative colitis.23473037
Autoimmune Diseases, Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingThese observations identify a role for SIRT1 in human autoimmunity and unveil a monogenic form of type 1 diabetes.23473037
Dyslipidemias, Demographics Domain, Hypertension, CTCAEDeregulated Nutrient SensingVitamin B12 levels were significantly lower and Hcy levels were significantly higher in subjects with dyslipidemia, DM, and/or hypertension.23473764
Breast CarcinomaDeregulated Nutrient SensingCBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.23474493
Breast CarcinomaDeregulated Nutrient SensingWe provide the first evidence that CBX8 plays a potential role in regulating premature senescence in human breast cancer cells through cooperation with SIRT1.23474493
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingChanges in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: interim outcomes from the GREAT2DO trial.23474589
ETV3 wt AlleleDeregulated Nutrient SensingIn addition, the combination increased UA, and hsCRP was also a significant and independent determinant for MetS and insulin resistance.23475511
Progranulins, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingPlasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance.23476101
Metabolic DiseasesDeregulated Nutrient SensingInsulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders.23476101
HypoadiponectinemiaDeregulated Nutrient SensingA novel mechanism for vascular insulin resistance in normotensive young SHRs: hypoadiponectinemia and resultant APPL1 downregulation.23478100
Hypertension, CTCAEDeregulated Nutrient SensingVascular insulin resistance contributes to elevated peripheral vascular resistance and subsequent hypertension.23478100
Periodontitis, DyslipidemiasDeregulated Nutrient SensingThe association between periodontitis and dyslipidemia based on the Fourth Korea National Health and Nutrition Examination Survey.23480442
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia is defined according to the definition proposed by the Korean Society of Lipidology and Atherosclerosis.23480442
Hypercholesterolemia, Periodontitis, DyslipidemiasDeregulated Nutrient SensingDyslipidemia except pre-hypercholesterolemia is associated with periodontitis.23480442
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a significant risk factor for premature cardiovascular disease.23480991
Postmenopausal state, Primary Biliary Cholangitis, ObesityDeregulated Nutrient SensingThe constellation of obesity, insulin resistance, and serum adipocytokine levels is associated with the risk and prognosis of postmenopausal breast cancer (PBC).23481121
Hypertension, CTCAE, Lack of awareness finding, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLevel of unawareness and management of diabetes, hypertension, and dyslipidemia among adults in Luxembourg: findings from ORISCAV-LUX study.23483942
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAmong the diagnosed cases, 32%, 60%, and 85% were respectively unaware of their diabetes, hypertension and dyslipidemia.23483942
Hypertension, CTCAE, Lack of awareness finding, DyslipidemiasDeregulated Nutrient SensingIncreasing age and BMI were the strongest protective factors against unawareness of hypertension and dyslipidemia.23483942
Dyslipidemias, Lack of awareness findingDeregulated Nutrient SensingPoor health perception reduced significantly the risk of unawareness of dyslipidemia (OR = 0.27; 95% CI 0.11, 0.68).23483942
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingConcerning the management, diabetes was markedly better treated than hypertension and dyslipidemia.23483942
Dyslipidemias, Lipid Metabolism DisordersDeregulated Nutrient SensingConcerning dyslipidemia, only 9% of those with lipid disorder (70% of the population) were under medication vs. 61% not treated.23483942
Glucose Intolerance (disease)Deregulated Nutrient SensingThere is a prevalence of 10*4/100,000 schoolchildren with T2DM, and 7*5/100,000 with impaired glucose intolerance among schoolchildren in Trinidad.23485494
Left Ventricular Hypertrophy, Aortic valve calcificationDeregulated Nutrient SensingInsulin resistance and LVH progression in patients with calcific aortic stenosis: a substudy of the ASTRONOMER trial.23489530
Left Ventricular HypertrophyDeregulated Nutrient SensingIn this ASTRONOMER substudy, insulin resistance was a powerful independent predictor of progression to LVH in patients with AS.23489530
Obesity, VisceralDeregulated Nutrient SensingVisceral obesity and ensuing insulin resistance may thus present novel therapeutic targets in AS patients.23489530
Unipolar DepressionDeregulated Nutrient SensingThere was a significant negative association between major depression and insulin resistance among men.23489875
Depression, CTCAEDeregulated Nutrient SensingThere was no significant interaction between race/ethnicity and major depression on insulin resistance (Wald kh(2) = 4.2927, P = 0.2315).23489875
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHealth care professionals should be aware of risk factors for insulin resistance and develop interventions to help prevent the progression of insulin resistance to type 2 diabetes mellitus.23489875
Non-insulin HypoglycemicDeregulated Nutrient SensingHaplotype G-C was likely associated with non-insulin resistance (adjusted P = 0.011).23490372
DyslipidemiasDeregulated Nutrient SensingThe same degree of dyslipidaemia was seen when Inuit had a 10% higher BMI compared to non-Inuit.23495626
Primary malignant neoplasm, Breast CarcinomaDeregulated Nutrient SensingHomeostasis model assessment to detect insulin resistance and identify patients at high risk of breast cancer development: National Cancer Institute of Naples experience.23497533
CarcinogenesisDeregulated Nutrient SensingTherefore we focused specifically on insulin resistance to investigate clinically the potential role of insulin in breast carcinogenesis.23497533
Breast CarcinomaDeregulated Nutrient Sensing975 patients were enrolled and the association between MS, insulin resistance, and breast cancer was evaluated.23497533
Breast CarcinomaDeregulated Nutrient SensingHOMA-IR score was elevated in 49% of cases compared to 34% of controls [OR 1.86], suggesting that insulin resistance can nearly double the risk of breast cancer development.23497533
Breast CarcinomaDeregulated Nutrient SensingBoth android fat distribution and insulin resistance correlated to MS in the subgroup of postmenopausal women affected by breast cancer.23497533
Breast CarcinomaDeregulated Nutrient SensingOur results further support the hypothesis that MS, in particular insulin resistance and abdominal fat, can be considered as risk factors for developing breast cancer after menopause.23497533
Obesity, AtherosclerosisDeregulated Nutrient SensingInsulin resistance, subclinical left ventricular remodeling, and the obesity paradox: MESA (Multi-Ethnic Study of Atherosclerosis).23500236
ObesityDeregulated Nutrient SensingRecent studies have suggested that central obesity and insulin resistance may be primary mediators of obesity-related cardiac remodeling independent of body mass index (BMI).23500236
ObesityDeregulated Nutrient SensingThese results support the emerging hypothesis that the cardiometabolic phenotype, defined by insulin resistance and central obesity, may play a critical role in LV remodeling independently of BMI.23500236
Hepatitis C, ChronicDeregulated Nutrient SensingImpairment of health-related quality of life in patients with chronic hepatitis C is associated with insulin resistance.23503838
Hepatitis CDeregulated Nutrient SensingInsulin resistance (IR) is recognized as a distinct aspect of chronic HCV infection.23503838
ObesityDeregulated Nutrient SensingHigh-normal TSH values in obesity: is it insulin resistance or adipose tissue's guilt?23505173
ObesityDeregulated Nutrient SensingOur study suggests that the increase in visceral adipose tissue is the best predictor of TSH concentration in obesity, independently from the eventual concurrent presence of insulin resistance.23505173
Sedentary lifestyle, ObesityDeregulated Nutrient SensingSedentary behavior in children is positively associated with an increased risk of both obesity and insulin resistance.23505193
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTaken together, increased DNA methylation of the PPARGC1A promoter is unlikely to play a major causal role for the development of insulin resistance in FDR of patients with T2D.23505498
Myeloid Leukemia, Chronic, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWith regards to RAGE-mediated CML trapping into adipose tissue inducing dysregulation of pro-inflammatory cytokines, adipokines, and the development of obesity-related insulin resistance, and the potential involvement of sRAGE in feedback regulation of the toxic effects of AGE/RAGE-mediated signaling, this early decline might be of clinical impact in development of type 2 diabetes and its complications.23509221
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe links between obesity and type 2 diabetes include proinflammatory cytokines, insulin resistance, deranged fatty acid metabolism, and cellular processes.23510756
Hyperinsulinism, ObesityDeregulated Nutrient SensingObesity also leads to hyperinsulinaemia and insulin resistance, with a progressive decrease in insulin secretory function.23510756
Abnormality of mitochondrial metabolism, AtherosclerosisDeregulated Nutrient SensingCardiovascular risk factors such as aging, smoking, and insulin resistance may lead to atherosclerosis through various mechanisms of which their association with mitochondrial dysfunction may be one of them.23510829
Carotid AtherosclerosisDeregulated Nutrient SensingAttenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate's association with carotid atherosclerosis may be related to insulin resistance.23510829
Cessation of life, Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient Sensingthe increase in HDL-C and the reduction of insulin resistance and atherogenic LDL subfractions), support findings from the PROactive trial, where pioglitazone showed pleiotropic effects and reduced death, fatal myocardial infarction (MI) and non-fatal MI in T2DM patients with MS.23511244
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevious evidence indicates that pioglitazone may improve dyslipidemia in patients with Type 2 diabetes mellitus (T2DM).23511244
Metabolic Diseases, Dyslipidemias, ETV3 wt Allele, Obesity, Hyperuricemia, Hypertension, CTCAEDeregulated Nutrient SensingAlthough MetS was associated with obesity, dyslipidemia, glucose control, hypertension, and hyperuricemia, limited ability of MetS to indicate metabolic disease risk is suggested.23512735
Adrenal hyperplasiaDeregulated Nutrient SensingNon-classic adrenal hyperplasia (NCAH) has been associated with insulin resistance (IR).23513016
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTotal n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes.23517921
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes.23517921
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe use of PIs has also been associated with dyslipidemia and an increased risk of cardiovascular disease, but the underlying mechanisms remain elusive.23519392
Congenital adrenal hyperplasiaDeregulated Nutrient SensingQuality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE).23520247
Chronic active hepatitisDeregulated Nutrient SensingIncreased adiposity, insulin resistance and use of prednisolone or dexamethasone are associated with impaired QoL in adults with CAH.23520247
Non-alcoholic Fatty Liver Disease, Hepatic inflammationDeregulated Nutrient SensingNAFLD is associated with insulin resistance and hepatic inflammation.23522007
Depression, CTCAEDeregulated Nutrient SensingSimilarly, patients with depression exhibit insulin resistance and increased inflammatory markers.23522007
Alzheimers Disease", Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingThe current study suggests that in an elderly sample of Alzheimer's caregivers, nighttime sleep duration, nighttime sleep efficiency and daytime naps are not significantly associated with prevalent type 2 diabetes, dyslipidemia, or hypertension.23522093
Hyperglycemia, Hypertriglyceridemia, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn the absence of obesity, the presence of fasting hyperglycemia, insulin resistance, hypertriglyceridemia, and/or hypertension defined the presence of MONW phenotype.23523313
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingPolymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations.23524405
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingThese findings suggest that functional SNPs of mTORC1 genes may individually or collectively contribute to ESCC risk.23524405
Cerebral IschemiaDeregulated Nutrient SensingThe effect of insulin resistance on inflammatory response and oxidative stress in acute cerebral ischemia.23524624
Inflammation, Acute Cerebrovascular AccidentsDeregulated Nutrient SensingInsulin resistance (IR) has effects on inflammation and oxidative stress which have importance in acute stroke.23524624
Inflammation, Cerebrovascular accidentDeregulated Nutrient SensingInflammation and oxidative stress are more evident in acute stoke patients with insulin resistance which may cause worse stroke severity.23524624
Ischemic strokeDeregulated Nutrient SensingOur data also suggest that IL-10 as an antiinflammatory cytokine can be much lower in insulin resistance in acute phase of ischemic stroke.23524624
Fatty LiverDeregulated Nutrient SensingWhen the participants were categorized by the overall degree of fatty liver, hepatic steatosis was significantly associated with the aspartate aminotransferase level (P = .028), ALT level (P = .003), and diastolic blood pressure (P = .05) but did not correlate with age, sex, Latino race, or insulin resistance.23525389
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingBMI was strongly associated with increased relative risk of cardiovascular disease, dyslipidemia, type 2 diabetes, and hypertension in the young and middle aged, however, the association between BMI and these metabolic conditions were much more attenuated with increasing age.23525474
Primary malignant neoplasmDeregulated Nutrient SensingIf an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including cancer, unraveling new proximal causes through which AMPK activation endows its gerosuppressive effects may offer not only a better understanding of metformin function but also the likely possibility of repositioning our existing gerosuppressant drugs.23525940
Refractory anemias, ETV3 wt AlleleDeregulated Nutrient SensingDespite their increased insulin resistance, South Korean women with RA did not have a significantly higher frequency of MetS compared with that in healthy subjects.23526131
Glucose Intolerance (disease), Tacca leontopetaloides, Ischemic strokeDeregulated Nutrient SensingGlucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA.23527528
Glucose Intolerance (disease), Tacca leontopetaloides, Ischemic strokeDeregulated Nutrient SensingThe relation between high on-treatment platelet reactivity (HPR), and the level of glucose intolerance and insulin resistance (IR) was studied in clopidogrel-treated patients with minor ischemic stroke or TIA.23527528
Glucose Intolerance (disease), metabolic disturbanceDeregulated Nutrient SensingA metabolic disturbance with glucose intolerance and/or high level of IR was a pre-requisite for HPR in the tested cohort.23527528
Dyslipidemias, Heart failure, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia is a known risk factor for coronary disease, but its role in heart failure (HF) development is less well-defined.23529112
Communicable DiseasesDeregulated Nutrient SensingThe data obtained by the patient's close monitoring suggest a direct interaction between insulin resistance and an active HCV genotype 1 infection, with a leading role played by the infection, and not by insulin resistance, as demonstrated by the sharp fall of the insulin units needed per day during treatment.23529134
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingA1C >=5.7% identified the subgroup of PCOS patients with higher insulin resistance, inadequate compensatory insulin response, impaired glucose disposition, and increased cardiovascular risk factors.23529348
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingThe objectives of this study were to investigate the effects of omega-3 fatty acids on obesity status, insulin resistance, and serum levels of visfatin in PCOS patients.23529993
Heart Diseases, DyslipidemiasDeregulated Nutrient SensingModelling for confounding interactions of concurrent dyslipidaemia, heart disease and other risk factors suggested that this marker is an independent predictor of AAA susceptibility.23535823
Cerebral InfarctionDeregulated Nutrient SensingInsulin resistance and risk of cerebral infarction in a Japanese general population: the Jichi Medical School Cohort Study.23536233
Cerebral InfarctionDeregulated Nutrient SensingThe aim of the study was to investigate the relation between insulin resistance and risk of cerebral infarction in a Japanese general population.23536233
Dyslipidemias, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingAssociation of dyslipidemia with renal cell carcinoma: a 1:2 matched case-control study.23536888
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMTM members with hypertension and dyslipidemia had pre-post increases in MPR of 2.29% and 2.10%, respectively, while the control group had decreases of 2.31% and 2.61% (both P less than 0.001).23537457
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMTM interventions were associated with a significant decrease in the MTM members' overall plan-paid health care costs, driven largely by decreases in inpatient utilization and mediated by increases in average days supply and in MPR increases for hypertension and dyslipidemia.23537457
Colorectal Neoplasms, DyslipidemiasDeregulated Nutrient SensingThere is suggestive but sparse evidence that dyslipidemia is associated with colorectal neoplasms.23545715
Dyslipidemias, ObesityDeregulated Nutrient SensingInsufficient nocturnal HR lowering in women with AH was not associated with significant changes of the myocardium and kidney and clear cat links with dyslipidemia, obesity, and smoking.23548350
Diabetes MellitusDeregulated Nutrient SensingLoss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes.23549584
Diabetes MellitusDeregulated Nutrient SensingAdditionally, in a cross-sectional analysis of persons without diabetes, lower nocturnal melatonin secretion was associated with increased insulin resistance.23549584
HD Term TypeDeregulated Nutrient SensingStudies in different animal models provide convincing evidence that SIRT1 protects neurons in mouse models of HD as well as in Caenorhabditis elegans, although controversial results were reported in a fly model.23549885
HD Term TypeDeregulated Nutrient SensingAs a result, pharmacological interventions targeting SIRT1 might become promising strategies to combat HD.23549885
HD Term TypeDeregulated Nutrient SensingThis review summarizes recent progress in SIRT1 research, with a focus on the specificity of this protein as a potential therapeutic target for HD, as well as existing challenges for developing SIRT1 modulators for clinical use.23549885
Huntingtons Disease PathwayDeregulated Nutrient SensingTargeting sirtuin-1 in Huntington's disease: rationale and current status.23549885
Dyslipidemias, Electrocardiogram: left ventricle hypertrophy (finding), Kidney Failure, Diabetes MellitusDeregulated Nutrient SensingOf 7032 participants, cardiovascular risk factors were prevalent, with 15.1% current smokers, 26.1% obese, 22.8% with diabetes mellitus, 35.1% with dyslipidemia, 12.0% with left ventricular hypertrophy, and 4.9% with renal insufficiency.23551730
Ischemia, Glucose Intolerance (disease), MELAS geneDeregulated Nutrient SensingExcitability of median nerve axons at the wrist was studied in 13 patients with MELAS (6 with glucose intolerance) and 17 control subjects in response to ischemia due to inflation of a cuff around the arm for 10 min.23553640
Juvenile arthritis, Dyslipidemias, ObesityDeregulated Nutrient SensingCoincident obesity is common in JIA children and is associated with insulin resistance, dyslipidemia, and increased levels of inflammatory markers leading to early changes in cardiovascular system.23554546
ObesityDeregulated Nutrient SensingIron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations.23555610
square decimeter, Erectile dysfunctionDeregulated Nutrient SensingIn vitro, exposure of cardiomyocytes to conditioned media derived from epicardial adipose tissue from patients with DM2 induced contractile dysfunction and insulin resistance, which was prevented by the addition of recombinant omentin.23555749
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingAssociation between dyslipidemia and chronic kidney disease: a cross-sectional study in the middle-aged and elderly Chinese population.23557545
Dyslipidemias, Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, a well-known risk factor for cardiovascular disease, is common in patients with kidney disease.23557545
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThus, we assessed whether the growing prevalence of dyslipidemia could increase the risk of CKD.23557545
Dyslipidemias, Albuminuria, Chronic Kidney DiseasesDeregulated Nutrient SensingAs the number of dyslipidemia components increased, so did the OR of CKD: 0.87 (95%CI 0.65 - 1.15), 1.29 (95%CI, 0.83 - 2.01), and 7.87 (95%CI, 3.75 - 16.50) for albuminuria, and 0.38 (95%CI 0.21 - 0.69), 1.92 (95%CI 1.14 - 3.25), and 5.85 (95%CI 2.36 - 14.51) for reduced eGFR, respectively.23557545
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingOur findings indicate that dyslipidemias increase the risk of CKD in the middle-aged and elderly Chinese population.23557545
Prediabetes syndrome, Chronic Kidney DiseasesDeregulated Nutrient SensingMultivariate logistic analysis was used to analyze the risk factors of CKD and prediabetes, and association of insulin resistance (IR) with CKD and prediabetes was analyzed.23557546
Prediabetes syndrome, Chronic Kidney DiseasesDeregulated Nutrient SensingCKD and prediabetes have become a major public health problem in Zhuhai, Southern China; insulin resistance may be an important risk factor.23557546
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingDiabetes-free survival was significantly prolonged when islet yield per gram of pancreas weight was more than 5154 islet equivalents (IEQ)/g, even in patients with prediabetes and high insulin resistance who had a markedly high rate of diabetes development.23558506
Pancreatic Neoplasm, Prediabetes syndromeDeregulated Nutrient SensingPartial (50%-60%) pancreatectomy for benign pancreatic tumors had a major metabolic consequence, especially in patients with prediabetes and high insulin resistance.23558506
DyslipidemiasDeregulated Nutrient SensingLMDT after AAA is associated with an increased survival compared with patients who were not using drug therapy for dyslipidemia.23561430
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingAggressive management of dyslipidemia should be considered in all patients undergoing AAA repair irrespective of other atherosclerotic disease status and risk factor profile.23561430
Demographics DomainDeregulated Nutrient SensingThe ACS of 3 and greater, which corresponded well to the highest quartile, was significantly and negatively associated with serum OC and ucOC levels in men by logistic regression analyses after adjusting for age, BMI, serum levels of creatinine and LDL cholesterol, radial bone mineral density, smoking, duration of DM, hemoglobin A1c, and the index of insulin resistance [odds ratio (OR) 0.36, 95 % confidence interval (CI) 0.19-0.70, P < 0.005, and OR 0.28, 95 % CI 0.12-0.69, P < 0.01, per standard deviation increase in OC and ucOC, respectively].23563931
DyslipidemiasDeregulated Nutrient SensingWe did not find any difference between the group of patients with and that without dyslipidemia and low or normal levels of vitamin D(3).23564349
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe findings regarding dyslipidemia, bone markers, and site specificity support the hypothesis that reduced blood flow is the key factor responsible for the inverse association of BMD with atherosclerosis.23564349
Thyroid carcinomaDeregulated Nutrient Sensing"Is there any association between insulin resistance and thyroid cancer?23564559
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIn multivariable analyses, age, hypertension, dyslipidemia, recent CD4(+) cell count <=200 cells/mm(3), and recent HIV RNA >400 copies/ml were associated with an increased risk of CVE.23565888
Inflammation, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingVitamin D (VD) may be implicated in obesity and its complications such as insulin resistance, hypertension, and low-grade inflammation.23566943
Infarction, DyslipidemiasDeregulated Nutrient SensingThis study revealed the increased prevalence of dyslipidemia to be more prevalent in 31-40 year males, suggesting that this group is at an increased risk of developing CAD leading to young infarcts.23569786
HyperthyroidismDeregulated Nutrient SensingCirculating glucagon to ghrelin ratio as a determinant of insulin resistance in hyperthyroidism.23572405
Coronary Occlusion, Hypertension, CTCAE, Stenosis Morphology, DyslipidemiasDeregulated Nutrient SensingWithin the CAD patient group, dose-response curves of L-selectin showed significant differences in the presence of hypertension, dyslipidemia, coronary occlusion and degree of stenosis, whereas CD11b expression had the strongest discriminating power after single dose stimulation.23573259
Heart failureDeregulated Nutrient SensingInsulin resistance and risk of incident heart failure: Cardiovascular Health Study.23575256
Heart failureDeregulated Nutrient SensingPatients with heart failure (HF) have higher fasting insulin levels and a higher prevalence of insulin resistance as compared with matched controls.23575256
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAfter adjustment for covariates, we observed that hypertension, diabetes, chronic kidney disease and dyslipidemia were positively and significantly associated with aPWV.23575382
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingAccording to epidemiological studies, dyslipidaemia is the commonest risk factor of atherosclerosis in the Polish population.23575780
Adrenal incidentalomaDeregulated Nutrient SensingMifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol: a pilot study.23577182
Adrenal incidentalomaDeregulated Nutrient SensingCortisol excess is known to cause insulin resistance, an independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their insulin resistance is secondary to the excess cortisol and therefore potentially reversible.23577182
Adrenal incidentalomaDeregulated Nutrient SensingShort-term GR antagonism is sufficient to reduce insulin resistance in some individuals with adrenal incidentalomas and mild cortisol excess.23577182
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe patients with CAD had a lower systolic blood pressure and heart rate, a lower incidence of diabetes, and greater incidence of dyslipidemia.23582626
Fibrosis Assessment, Neoplasm MetastasisDeregulated Nutrient SensingSIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis.23583181
Fibrosis Assessment, Breast CarcinomaDeregulated Nutrient SensingReduced SIRT1 levels in HMLER breast cancer cells led to increased metastases in nude mice, and the loss of SIRT1 in kidney tubular epithelial cells exacerbated injury-induced kidney fibrosis.23583181
Primary malignant neoplasm, Fibrosis AssessmentDeregulated Nutrient SensingSIRT1 reduces EMT in cancer and fibrosis by deacetylating Smad4 and repressing the effect of TGF-b signaling on MMP7, a Smad4 target gene.23583181
Polycystic Ovary SyndromeDeregulated Nutrient SensingThe visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome.23585246
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe VAI can replace visceral CT scanning as a marker for visceral adiposity, and it predicts insulin resistance in young women with PCOS.23585246
AtherosclerosisDeregulated Nutrient SensingHigher levels of AOPPs, AGEs, oxLDL, NOx, atherosclerosis risk markers, and insulin resistance were pointed out in IFG and T2DM groups compared with control.23587667
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe risk of AF recurrence in PAF patients increased in the presence of hypertension, dyslipidemia, large left atrial diameter (LAD) and low ejection fraction.23588029
Weight decreasedDeregulated Nutrient SensingInsulin resistance may play a negative role in maintaining weight loss.23588462
Refractory anemias, Rheumatoid Arthritis, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, a risk factor for cardiovascular diseases, is more prevalent in patients with rheumatoid arthritis (RA) than in the general population.23588940
Refractory anemias, Dyslipidemias, Chronic inflammatory disorderDeregulated Nutrient SensingThese results provide the first evidence that genetic mechanisms linked to dyslipidemia may directly contribute to the susceptibility and prognosis of RA, a representative of chronic inflammatory diseases, explaining the high incidence of dyslipidemia in RA.23588940
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDietary n-3 long-chain PUFA (LC-PUFA) improve dyslipidaemia and hypertension and may affect insulin resistance and adiposity.23591057
ObesityDeregulated Nutrient SensingThese associations remained after stratification for sex, traditional risk factors of CVD and insulin resistance, but were attenuated after taking a measure of obesity (body mass index) into account.23591414
Hypertension, CTCAE, HaitiDeregulated Nutrient SensingHigh sodium (HS) diet is associated with hypertension (HT) and insulin resistance (IR).23594269
Dyslipidemias, HaitiDeregulated Nutrient SensingAlso, HS diet was associated with HT, insulin resistance, dyslipidaemia and hypoadiponectinaemia, even when adjusting by confounding variables.23594269
Diabetic Nephropathy, Inflammation, Injury of kidneyDeregulated Nutrient SensingNOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy.23594678
Diabetic Nephropathy, Inflammation, Injury of kidneyDeregulated Nutrient SensingThus, NOD2 is one of the critical components of a signal transduction pathway that links renal injury to inflammation and podocyte insulin resistance in diabetic nephropathy.23594678
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingMultivariate Logistic regression analysis showed that high blood glucose and abdominal obesity were significantly related to the prevalence of dyslipidemia, urine iodine concentration was no significant correlation with the prevalence of dyslipidemia.23596701
Inflammation, Sleep Apnea SyndromesDeregulated Nutrient SensingSleep apnoea, sleepiness, inflammation and insulin resistance in middle-aged males and females.23598957
Inflammation, Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingIn obese males obstructive sleep apnoea (OSA) is associated with inflammation and insulin resistance; however, findings are confounded by adipose tissue, a hormone- and cytokine-secreting organ.23598957
Inflammation, Osage languageDeregulated Nutrient SensingIn conclusion, OSA is associated with sleepiness, inflammation and insulin resistance, even in nonobese males, and this association is stronger in males than in females.23598957
AtherosclerosisDeregulated Nutrient SensingDespite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated.23599442
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelative contributions of insulin resistance and b-cell dysfunction to the development of Type 2 diabetes in Koreans.23600561
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingControversies still exist regarding the relative contributions of insulin resistance and b-cell dysfunction to the pathogenesis of Type 2 diabetes in different populations.23600561
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined the associations of baseline insulin resistance and b-cell function indices with the development of Type 2 diabetes in Koreans.23600561
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn individuals with low BMI, b-cell dysfunction is the predominant defect, whereas insulin resistance is the predominant pathogenetic factor in individuals with high BMI in the development of Type 2 diabetes in Koreans.23600561
AHSG protein, human, Non-alcoholic Fatty Liver Disease, Arterial calcificationDeregulated Nutrient SensingFetuin-A inhibits arterial calcification, induces insulin resistance, and is increased in NAFLD.23600632
Arterial Stiffness, Cavia, Carotid Intima-Media Thickness, Diabetes MellitusDeregulated Nutrient SensingAlthough many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased arterial stiffness evaluated by means of carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI).23601500
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Erectile dysfunction, Renal Insufficiency, Hypertension, CTCAE, AIDS-Related Malignant NeoplasmDeregulated Nutrient SensingThe number of comorbidities increased with age and the same pattern was observed for the majority of the comorbidities, including diabetes mellitus, dyslipidemia, hypertension, cardiovascular diseases, erectile dysfunction, HCV, renal dysfunction and also for non-AIDS-related cancers (p<0.001).23602466
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMultivariable models were adjusted for age, smoking, cardiovascular disease, hypertension, diabetes, dyslipidaemia, body mass index and serum creatinine concentration.23602862
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Bone Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVitamin D deficiency is a well-established risk factor for bone disease, but emerging data suggest that altered vitamin D homeostasis may play a role in the development of type 2 diabetes mellitus (T2DM), dyslipidemia hypertension, and other cardiovascular diseases (CVD).23607183
Weight Gain, Diabetes MellitusDeregulated Nutrient SensingWhole grains may offer protection from diabetes by decreasing energy intake, preventing weight gain, and direct effects on insulin resistance.23608304
Temporal Lobe, Disorder of renal parenchyma, DyslipidemiasDeregulated Nutrient SensingTo our knowledge, this is the first report of an unusual association between bilateral temporal lobe agenesis associated with renal parenchymal disease and dyslipidaemia.23612653
Gastrointestinal carcinomaDeregulated Nutrient SensingParenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma.23612677
Malignant neoplasm of gastrointestinal tractDeregulated Nutrient SensingThe aim was to compare preventive effect of total parenteral nutrition (TPN) and oral nutrition (preOp) on the perioperative insulin resistance prevention in surgical gastrointestinal cancer patients.23612677
millicurie, Impaired cognition, Data types - AddressDeregulated Nutrient SensingThe present study evaluated the alterations in serum sirtuin1 (SIRT1) concentration in healthy individuals (young and old) and patients with AD and mild cognitive impairment (MCI).23613875
Data types - AddressDeregulated Nutrient SensingA significant (p<0.0001) decline in SIRT1 concentration was observed in patients with AD (2.27 +- 0.46 ng/ul) and MCI (3.64 +- 0.15 ng/ul) compared to healthy elderly individuals (4.82 +- 0.4 ng/ul).23613875
Dyslipidemias, Hyperglycemia, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingProlonged sitting is associated with increased weight and higher risks for abdominal obesity, dyslipidaemia, hyperglycaemia and hypertension among the adult population.23613917
Prediabetes syndromeDeregulated Nutrient SensingParticipants with prediabetes have lower zinc levels than controls and zinc is significantly associated with beta cell function and insulin resistance.23613929
palladium, DyslipidemiasDeregulated Nutrient SensingAfter demographic adjustment, T2DM patients with PD showed a significantly lower HbA1c (58.0 vs. 60.3 mmol/mol; p < 0.0001), OAD/GLP-1 treatment (41.9 vs. 45.9%; p < 0.01) and frequency of dyslipidemia (62.0 vs. 64.5%; p < 0.05).23615668
Hyperactive behavior, Neurodevelopmental DisordersDeregulated Nutrient SensingOur findings demonstrate a mechanistic link between STRADA loss and mTORC1 hyperactivity in PMSE, and suggest that mTORC1 inhibition may be a potential treatment for PMSE as well as other mTOR-associated neurodevelopmental disorders.23616120
DyslipidemiasDeregulated Nutrient SensingSmall, dense low-density lipoprotein (LDL) particles are highly atherogenic and strongly associated with obesity-related dyslipidemia.23616363
DyslipidemiasDeregulated Nutrient SensingDefinitions of CVD risk vary and prevalence of dyslipidemia (abnormal total cholesterol, high-density lipoprotein (HDL-C), or non-HDL-C) among at-risk women may vary by age and definition of CVD risk.23621744
acetohydroxamic acid, DyslipidemiasDeregulated Nutrient SensingThe AHA risk definition identified 45% more young women and 25% more older women than the USPSTF risk definition; however, both definitions of at-risk identified similar prevalence estimates of dyslipidemia among women.23621744
Optic Disk, Dyslipidemias, Diabetes Mellitus, Retinal Vein Occlusion, Corneal diameterDeregulated Nutrient SensingWe found that PEX was not associated (all P>0.05) with sex, diabetes mellitus, blood pressure, psychological depression, smoking, dyslipidemia, body mass index, central corneal thickness, corneal diameter, optic nerve head measurements, choroidal thickness, retinal vessel diameters, early age-related macular degeneration, or retinal vein occlusion.23622877
Glucose Intolerance (disease), Mitochondrial Diseases, Polyneuropathy, Alcoholic Intoxication, ChronicDeregulated Nutrient SensingPrevious reports have shown that this disease is associated with alcoholism, polyneuropathy, mitochondrial disease, and glucose intolerance.23623508
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThe comorbidities may include insulin resistance, type II diabetes mellitus, hypertension and cardiovascular disease.23624031
metabolic disturbanceDeregulated Nutrient SensingAging may also be associated with increased risk of insulin resistance and metabolic disturbances.23624031
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingThe deterioration of insulin resistance during the reproductive life of women with PCOS appears to be mainly attributable to the increase in obesity.23624031
metabolic disturbanceDeregulated Nutrient SensingTherefore, if body weight could be controlled properly, younger hyperandrogenic PCOS women might reduce their risk of insulin resistance and metabolic disturbances later in life.23624031
Dyslipidemias, Ulcerative ColitisDeregulated Nutrient SensingAn intervention (IT) cohort of 213 patients referred for management of dyslipidemia by clinical pharmacists and a control cohort of 219 patients with dyslipidemia receiving usual care (UC).23625745
Diabetes MellitusDeregulated Nutrient SensingLaboratory studies suggest that fine particulate matter (<= 2.5 um in diameter; PM(2.5)) can activate pathophysiological responses that may induce insulin resistance and type 2 diabetes.23632126
Systolic PressureDeregulated Nutrient SensingInsulin resistance, total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, sum of two skinfolds and systolic blood pressure (SBP) z-scores were summed to compute a CVD risk score.23632753
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAssociation of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease.23633195
Arterial Stiffness, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingWe investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects.23633195
Arterial Stiffness, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingA gender-based difference in circulating glypican-4 levels was apparent as these were increased in women with NAFLD and related to body fat distribution, insulin resistance, and arterial stiffness.23633195
Thrombosis, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is associated with tunneled-cuffed catheter-related central venous thrombosis in hemodialysis patients: a retrospective, multicenter study.23634689
Vertical Talus, DyslipidemiasDeregulated Nutrient SensingPatients with CVT had a higher prevalence of dyslipidemia (50.74 vs. 26.85%, respectively) and low protein store compared with the control group.23634689
DyslipidemiasDeregulated Nutrient SensingDyslipidemia and low serum albumin levels were significantly associated with TCC-related CVT in hemodialysis patients.23634689
Inflammation, AtherosclerosisDeregulated Nutrient SensingPioglitazone, an anti-diabetic agent that improves insulin resistance, was also reported to decrease inflammation and protect against atherosclerosis.23635096
glycation, Diabetes MellitusDeregulated Nutrient SensingIn diabetes, dietary advanced glycation end products (dAGEs) cause OS/Infl and suppress SIRT1.23636469
Metabolic DiseasesDeregulated Nutrient SensingIn conclusion, chronic consumption of high-AGE diets depletes defenses such as SIRT1 and PPARg, independent of calories, predisposing to OS/Infl and chronic metabolic disease.23636469
ObesityDeregulated Nutrient SensingRecently, the novel myokine irisin was described to drive adipose tissue 'browning', to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice.23637927
Dyslipidemias, Disorder of the optic nerveDeregulated Nutrient SensingIn multivariate analysis, higher RNFL visibility score was associated with younger age (P<0.001; standardized coefficient beta: -0.44; regression coefficient B: -0.22; 95%CI: -0.24, -0.20), female gender (P<0.001; beta: 0.11; B: 1.00; 95%CI: 0.67, 1.32), higher blood concentration of low-density lipoproteins (P = 0.002; beta: 0.07; B: 0.34; 95%CI: 0.13, 0.56), absence of dyslipidemia (P = 0.001; beta: -0.07; B: -0.58; 95%CI: -0.93, -0.24), lower blood glucose concentration (P = 0.006; beta: -0.05; B: -0.14; 95%CI: -0.24, -0.04), hyperopic refractive error (P<0.001; beta: 0.15; B: 0.45; 95%CI: 0.34, 0.56), smaller optic disc size (P<0.001; beta: -0.08; B: -0.72; 95% CI: -1.04, -0.40), absence of glaucomatous optic neuropathy (P<0.001; beta: -0.06; B: -2.69; 95%CI: -4.18, -1.21) and absence of non-glaucomatous optic nerve damage (P = 0.001; beta: -0.06; B: -4.80; 95%CI: 0.23637954
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, dyslipidemia, and diabetes are established risk factors for cardiovascular disease (CVD) morbidity and mortality.23638684
Obesity, Diabetes MellitusDeregulated Nutrient SensingCirculating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases.23642261
DyslipidemiasDeregulated Nutrient SensingDespite available medications for dyslipidemia, many treated patients still have suboptimal lipid levels.23642513
Dyslipidemias, ras GTPase-Activating ProteinsDeregulated Nutrient SensingIn conclusion, despite widely available treatments for dyslipidemia, many patients remain at suboptimal lipid levels, indicating need for greater adherence to lifestyle and medical therapies to address these gaps in the management of dyslipidemia.23642513
Hypertension, CTCAEDeregulated Nutrient SensingMultivariate logistic regression analysis showed that GA/AA was associated with an increased risk of hypertension in synergy with high insulin level and insulin resistance.23644116
Dyslipidemias, Malignant Neoplasms, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFurthermore, both the genes harboring DMCs and the genes harboring DVCs showed significant enrichment of genes identified by genome-wide association studies on obesity and related diseases, such as hypertension, dyslipidemia, type 2 diabetes and certain types of cancers, supporting their roles in the etiology and pathogenesis of obesity.23644594
Angina, Unstable, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Hypertension, CTCAEDeregulated Nutrient SensingCompared with the ST-elevation myocardial infarction subgroup, the unstable angina and non-ST-elevation myocardial infarction patients had higher frequencies of hypertension, diabetes, prior coronary heart disease (p<0.001) and dyslipidemia (p = 0.03).23644870
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cerebrovascular accidentDeregulated Nutrient SensingThe prevalence of type 2 diabetes, hypertension and insulin resistance was higher in the group of patients with stroke.23645309
Dyslipidemias, ETV3 wt AlleleDeregulated Nutrient SensingLifestyle interventions for reducing PBF and controlling dyslipidemia could help reduce the risk of MetS in this population.23647841
Myocardial, GDC AJCC Clinical Stage Terminology, Diabetes MellitusDeregulated Nutrient SensingIn patients with ACS and without previously known diabetes, acute insulin resistance (HOMA index) is associated with a larger myocardial damage (ie, higher values of peak Tn I and lower LVEF) and a greater inflammatory activation (indicated by correlation with leukocyte count).23650645
Diabetes MellitusDeregulated Nutrient SensingThe influence of pre-natal conditions on later type 2 diabetes risk factors such as insulin resistance (IR) may be mediated by post-natal growth trajectory.23652936
Aggressive courseDeregulated Nutrient SensingE2 potentiates miR-34a downregulation thus enhancing SIRT1 expression, depicting a novel eNOS/SIRT1 interplay fine-tuned by E2-activated ER signaling, and suggesting that eNOS may play an important role in aggressive PCa.23658738
Hypercholesterolemia, Obesity, Abdominal, Hyperinsulinism, Hypertension, CTCAEDeregulated Nutrient SensingSerum 25(OH)D levels were statistically lower in adolescents with weight excess, abdominal obesity, hypercholesterolaemia, higher levels of parathyroid hormone, insulin resistance, hyperinsulinaemia and hypertension (P < 0.05).23659537
Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCommon variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies.23659870
AcromegalyDeregulated Nutrient SensingInsulin resistance improved when acromegaly was controlled with therapy with SSAs, PEG, or SSA+PEG.23660641
AcromegalyDeregulated Nutrient SensingMedical therapies for acromegaly reduce insulin resistance and increase insulin sensitivity; on the contrary, glucose indexes may be differently affected by SSA or PEG therapy.23660641
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingIncidence of MI is increasing among hospital admissions in Ilorin and there is an urgent need for community interventions targeted at early detection and treatment of hypertension, diabetes mellitus, dyslipidaemia and obesity.23661202
Irregular Menstruation, Oligomenorrhea, HyperandrogenismDeregulated Nutrient SensingAlthough menstrual irregularity is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with oligomenorrhoea (OM) is unclear.23663009
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn normal-weight women (BMI < 23 kg/m(2)), the degrees of insulin resistance and hyperandrogenaemia are the highest in PCOS and higher in severe OM compared with mild OM.23663009
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Asthma, Hypertension, CTCAEDeregulated Nutrient SensingOverall, 19% of patients had comorbid asthma, 66% hypertension, 61% dyslipidemia, 30% cardiovascular disease, and 28% diabetes.23663130
AcromegalyDeregulated Nutrient SensingImprovement of insulin resistance following transsphenoidal surgery in patients with acromegaly: correlation with serum IGF-I levels.23665535
AcromegalyDeregulated Nutrient SensingIn patients with acromegaly, serum IGF-I levels, but not GH levels, were significantly correlated with insulin resistance.23665535
Glucose Intolerance (disease), AcromegalyDeregulated Nutrient SensingThe aim of this study was to determine the correlation between the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis and glucose intolerance in acromegaly during the early postoperative period.23665535
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingEpidemiologic data suggest that non-alcoholic fatty liver disease (NAFLD) have an increased tendency to occur in patients who are associated with metabolic conditions such as obesity, type 2 diabetes mellitus, and dyslipidemia.23672077
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingComparison of pitavastatin with atorvastatin in increasing HDL-cholesterol and adiponectin in patients with dyslipidemia and coronary artery disease: the COMPACT-CAD study.23672789
HypertriglyceridemiaDeregulated Nutrient SensingMetabolic factors linked with coagulation factors were hypertriglyceridaemia (tPA, P < 0.05; PAI-1, P < 0.05; protein C, P < 0.05) and insulin resistance (tPA, P < 0.01; PAI-1, P < 0.01; vWF, P < 0.05).23673438
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingVitamin D status has been implicated in insulin resistance, type 2 diabetes mellitus, and hypertension, but the range of vitamin D status values over which the association can be found is unknown.23674796
HIV InfectionsDeregulated Nutrient SensingWe explored the relationship between vitamin D levels and insulin resistance (IR) among 1082 nondiabetic (754 HIV-infected) women enrolled in the Women's Interagency HIV study (WIHS), a large and well-established cohort of HIV infected and uninfected women in the US.23675750
Hepatitis CDeregulated Nutrient SensingEthnicity, body mass index, smoking status, and hepatitis C status were independently associated with insulin resistance in HIV-infected and uninfected women.23675750
Refractory anemias, Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingTo investigate how cholesteryl ester transfer protein (CETP), one of the enzymes involved in the reverse cholesterol transfer, is expressed in patients with rheumatoid arthritis (RA) and its potential relationship with both dyslipidemia and the risk of cardiovascular mortality observed in these patients.23678159
Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity and insulin resistance were also associated with a greater risk of elevated ALT.23678860
Dyslipidemias, Serum LDL cholesterol measurementDeregulated Nutrient SensingApolipoprotein B showed the strongest tracking in both sexes, stronger than for LDL-cholesterol, which supports the importance of determining apo B levels as a marker of dyslipidaemia in children.23679859
Hypertension, CTCAEDeregulated Nutrient SensingSimilar trends were observed for hypertension in boys and insulin resistance for both genders.23680122
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPattern and predictors of dyslipidemia in patients with type 2 diabetes mellitus.23680249
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia is a major risk factor for macro-vascular complications in patients with type 2 diabetes mellitus (T2DM).23680249
DyslipidemiasDeregulated Nutrient SensingPresent study explored pattern and predictors of dyslipidemia in Bangladeshi T2DM patients.23680249
DyslipidemiasDeregulated Nutrient SensingThe characteristic features of diabetic dyslipidemia are low HDL, high triglyceride and LDL cholesterol level.23680249
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPoor glycemic control, prolonged duration, coexisting hypertension predicts dyslipidemia in T2DM.23680249
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku study.23680915
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGreater insulin resistance indicates decreased diurnal variation in the QT interval in patients with type 2 diabetes.23681273
diabeticDeregulated Nutrient SensingHowever, the relationship between QT prolongation and the degree of insulin resistance as well as circadian variation remains unclear in diabetic patients.23681273
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study was designed to assess the relationship between insulin resistance and the circadian variation in QT measurements in patients with type 2 diabetes.23681273
Diabetes MellitusDeregulated Nutrient SensingPrevious studies have shown that hs-CRP is associated with insulin resistance, type 2 diabetes and higher HbA1c levels.23682523
Dyslipidemias, OverweightDeregulated Nutrient SensingPrevalence and risk factors of elevated blood pressure, overweight, and dyslipidemia in adolescent and young adults in rural Nepal.23682595
Dyslipidemias, OverweightDeregulated Nutrient SensingEthnic plains Madheshi were less likely to be overweight (0.3; 0.2-0.4), but had greater risk of dyslipidemia (1.4; 1.1-1.7) versus those of Hill origin.23682595
Hyperglycemia, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingPharmacotherapy to manage hyperglycaemia, dyslipidaemia and hypertension was widely prescribed.23683111
DyslipidemiasDeregulated Nutrient SensingAmongst individuals with dyslipidaemia, median low-density lipoprotein cholesterol (LDL-C) was 1.8 mmol/l for those with T2DM and 2.8 mmol/l for those without.23683111
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingChanges in the human gut microbiome are associated with type 2 diabetes and insulin resistance.23685372
Dyslipidemias, CalcinosisDeregulated Nutrient SensingThe release of proatherogenic substances by the steatotic liver or its contribution to insulin resistance and dyslipidemia may contribute to the development of calcification and sclerosis of the aortic valve.23685558
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a common contributory cause of cardiovascular disease.23686894
Glucose Intolerance (disease), Urinary tract infection, PneumoniaDeregulated Nutrient SensingGlucose intolerance, urinary tract infections, and pneumonia were the major side effects observed in this study.23689577
Steatohepatitis, DyslipidemiasDeregulated Nutrient SensingHowever, increasing evidence now suggests that total body irradiation treatment, specifically, is linked with future risk of insulin resistance, hepatic steatosis and dyslipidaemia, possibly because total body irradiation affects adipocyte differentiation and impairs subcutaneous adipose tissue depot expansion during times of positive energy balance.23692373
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrevious studies have linked vitamin D deficiency to hypertension, dyslipidemia, diabetes mellitus, and cardiovascular disease.23694999
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingElevated plasma free fatty acids (FFAs) are one important link between excess visceral adiposity, insulin resistance, and the development of type 2 diabetes.23695818
Hypertension, CTCAE, Endothelial dysfunctionDeregulated Nutrient SensingReduced NO availability is associated with endothelial dysfunction, hypertension, insulin resistance and cardiovascular remodeling.23698802
Hypertensive (finding)Deregulated Nutrient SensingBS/GS patients' mononuclear cell SIRT1 (western blot), FMD (B-mode scan of the right brachial artery) and heme oxygenase (HO)-1 (sandwich immunoassay), a potent antioxidant protein, were compared with the levels in untreated stage 1 essential hypertensive patients (HPs) and in healthy subjects (C).23698802
Hypertension, CTCAEDeregulated Nutrient SensingIncreased SIRT1 and its direct relationship with increased FMD in BS/GS patients, while strengthening the relationship among SIRT1, NO and vascular function in humans, point toward a role for reduced SIRT1 in the endothelial dysfunction of hypertension.23698802
OverweightDeregulated Nutrient SensingWe evaluated 70 subjects distributed in 12 non-obese lean subjects, 23 overweight subjects, 12 obese subjects and 23 nondiabetic morbidly obese patients (11 with low insulin resistance and 12 with high insulin resistance).23700440
Hyperglycemia, Sleep Apnea, ObstructiveDeregulated Nutrient SensingObstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance.23701956
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingExpression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer.23702379
Adenocarcinoma, Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingWe investigated SIRT1 and cortactin expression in 144 invasive non-small cell lung cancers (NSCLC) and 19 adenocarcinomas in situ (AIS) by immunohistochemistry and evaluated their clinicopathological significance in NSCLC.23702379
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingPositive SIRT1 and cortactin expression was observed in 67% (96 of 144) and 58% (84 of 144) of patients with invasive NSCLC, respectively.23702379
Adenocarcinoma, Neoplasm Metastasis, NeoplasmsDeregulated Nutrient SensingSIRT1 and cortactin expression was significantly associated with unfavorable clinicopathological factors, including high pathological T stage, lymph node metastasis, and advanced tumor invasion (AIS vs. invasive adenocarcinoma).23702379
Neoplasm Metastasis, NeoplasmsDeregulated Nutrient SensingCortactin was significantly associated with high pathological T stage and lymph node metastasis in SIRT1-positive tumors.23702379
NeoplasmsDeregulated Nutrient SensingCytoplasmic SIRT1 was significantly associated with high pathological T stage and large tumor size compared to that of nuclear SIRT1.23702379
Neoplasm Metastasis, NeoplasmsDeregulated Nutrient SensingLarge tumor size, high pathological T stage, lymph node metastasis, and cytoplasmic SIRT1 expression were significantly associated with shorter overall survival in a univariate analysis.23702379
Non-Small Cell Lung Carcinoma, NeoplasmsDeregulated Nutrient SensingOur findings suggest that SIRT1 and cortactin may play a role in the progression of NSCLC and may cooperate during tumor progression in NSCLC.23702379
Dyslipidemias, Diabetes Mellitus, Chronic disease, Asthma, Hypertension, CTCAEDeregulated Nutrient SensingChronic medical illness (mostly hypertension, dyslipidemia, asthma, and diabetes) was found in 82.4 %.23703373
Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingHepatic steatosis and NAFLD were also independently associated with diabetes, with insulin resistance among people without diabetes, with dyslipidemia, and with obesity.23703888
Ischemic strokeDeregulated Nutrient SensingDHEAS may influence ischemic stroke risk through atherosclerotic-related mechanisms (endothelial function and smooth muscle cell proliferation) or insulin resistance.23704104
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRisk factors for type 2 diabetes mellitus preceded by b-cell dysfunction, insulin resistance, or both in older adults: the Cardiovascular Health Study.23707958
Structure of beta Cell of islet, Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) and pancreatic b-cell dysfunction lead to type 2 diabetes mellitus (DM).23707958
Primary malignant neoplasmDeregulated Nutrient SensingIn vitro data revealed that metformin inhibited cancer cell growth, activated cAMP-inducible protein kinase (5'-AMP-activated protein kinase [AMPK]), and down-regulated p70S6K/pS6.23709654
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingDespite the benign nature of NAFLD, efforts should be directed toward early diagnosis, intensive blood glucose and blood pressure control, and effective dyslipidemia correction.23716995
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe remission of the skin lesions soon after control of dyslipidemia and diabetes mellitus is not typical for the usual GGA, which has a chronic relapsing course and a poor response to treatment.23720988
Hyperglycemia, ObesityDeregulated Nutrient SensingThe results suggest that even a moderate amount of dietary fiber intake may be beneficial for managing the fasting plasma glucose level concomitant with insulin resistance, body weight, and body mass index in Japanese men with mild hyperglycemia and visceral fat obesity.23725526
No metabolic abnormalitiesDeregulated Nutrient SensingIn peritoneal dialysis, the high glucose load absorbed from dialysis fluid contributes to several metabolic abnormalities, including insulin resistance.23725973
Fatty degenerationDeregulated Nutrient SensingIn animal models, OCA decreases insulin resistance and hepatic steatosis.23727264
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEzetimibe/simvastatin 10/20 mg is comparable to atorvastatin 20 mg for the management of dyslipidemia, and may have more favorable effects on apolipoprotein profiles than atorvastatin 20 mg in Korean patients with type 2 diabetes mellitus.23728830
Atrial Fibrillation, Dyslipidemias, Heart failure, Diabetes MellitusDeregulated Nutrient SensingPatients who developed AF, with respect to those who did not, were older and more frequently with NSTEMI at admission (69.2 vs. 53.5%, p = 0.013), diabetes, dyslipidemia and history of heart failure.23729385
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Skeletal muscle structureDeregulated Nutrient SensingAbdominal obesity, characterized by ectopic fat deposition in skeletal muscle and liver tissue, has been associated with insulin resistance and increased risk for type 2 diabetes mellitus.23731019
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance may be an independent risk factor for the development of hypertension, but change in blood pressure (BP) over time has not been adequately studied in healthy individuals fully characterized for insulin sensitivity.23734006
AATF wt Allele, Dry Eye Syndromes, DyslipidemiasDeregulated Nutrient SensingThis study aimed to determine the relationship between dyslipidemia and dry eye disease (DED) in a Korean population.23734839
AATF wt Allele, DyslipidemiasDeregulated Nutrient SensingDED in a Korean population was found to be associated with high serum cholesterol levelsThe results of this study highlight the significance of eye examinations and independent lipid profile monitoring in patients with dyslipidemia because of its possible correlation with DED progression.23734839
Prediabetes syndromeDeregulated Nutrient SensingIn obese individuals with prediabetes or early untreated DM, Aloe QDM complex reduced body weight, BFM, and insulin resistance.23735317
Decreased renal function, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance, incident cardiovascular diseases, and decreased kidney function among nondiabetic American Indians: the Strong Heart Study.23735722
ObesityDeregulated Nutrient SensingPrevalence of insulin resistance is high in the American Indian population, likely as a result of the high prevalence of obesity.23735722
Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingProspectively, insulin resistance is associated with the development of CVD and decreased kidney function in this population.23735722
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance may have an important role in the pathogenesis of CVD and chronic kidney disease.23735722
ObesityDeregulated Nutrient SensingSince obesity contributes to the development of insulin resistance, intervention focusing on modifiable factors such as physical activity and weight control may reduce the development of these diseases.23735722
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingTotal lipid management and cardiovascular disease in the dyslipidemia international study.23736147
Abnormality, Dyslipidemias, Heart failureDeregulated Nutrient SensingOverall, elevated LDL-C was the most frequent lipid anomaly observed, and preexisting heart failure was strongly and positively associated with dyslipidemia.23736147
Inflammation, Cardiac complication, ObesityDeregulated Nutrient SensingChildhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular complications later in life.23736361
ObesityDeregulated Nutrient SensingSecond, the association between 25(OH)D deficiency and insulin resistance in childhood obesity was confirmed with multiple regression analysis.23736361
Arterial StiffnessDeregulated Nutrient SensingThis study sought to determine the effect of Bikram yoga on arterial stiffness and insulin resistance in young and older adults.23738677
Arterial StiffnessDeregulated Nutrient SensingA relatively short-term Bikram yoga intervention improved arterial stiffness in young but not older adults and significantly reduced insulin resistance index in older but not young adults.23738677
Data types - AddressDeregulated Nutrient SensingAD and MCI cybrids exhibited differences in proteins that monitor, respond to or regulate cell bioenergetic fluxes including HIF1a, PGC1a, SIRT1, AMPK, p38 MAPK and mTOR.23740939
Increased insulin level, Glucose Intolerance (disease), Abnormality of mitochondrial metabolism, HyperglycemiaDeregulated Nutrient SensingAs a likely consequence of systemic mitochondrial dysfunction, Dync1h1 mutant mice develop hyperinsulinemia and hyperglycemia and progress to glucose intolerance with age.23742762
Apolipoproteins BDeregulated Nutrient SensingPlasma 25-hydroxyvitamin D was inversely associated with insulin, insulin resistance, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and the ratio of total to high-density lipoprotein cholesterol but not with fasting glucose, apolipoprotein A1, apolipoprotein B, C-reactive protein, fibrinogen, or homocysteine.23742939
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingNotwithstanding improving rates of hypertension control in North America, management of patients with both hypertension and dyslipidemia remains problematic.23743804
ObesityDeregulated Nutrient SensingThese adaptive processes might provide a valuable therapeutic target in the treatment of obesity and insulin resistance.23744406
Prostate carcinomaDeregulated Nutrient SensingInsulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients.23744766
TG geneDeregulated Nutrient SensingSeven days after surgery, significant reductions in the insulin resistance were observed, while TG and adiponectin levels remained unchanged during the meal test.23745620
ETV3 wt AlleleDeregulated Nutrient SensingIn children with MetS, the prevalence of insulin resistance, high insulin, high non-HDL(high-density lipoprotein) cholesterol and high uric acid was higher than in children without MetS.23746346
AHSG protein, human, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFetuin-A is an endogenous inhibitor of the insulin-stimulated insulin receptor tyrosine kinase recently shown that high levels of circulating fetuin-A are associated with insulin resistance in humans suggesting that fetuin-A may represent a novel mechanism involved in the pathophysiology of type 2 diabetes (T2DM).23748282
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAdministration of beraprost significantly reduced patient-reported severity of lower limb ischemic symptoms in all patients at 12 months, including those with diabetes, hypertension, or dyslipidemia.23749750
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDecreases in IMT were similar in patients with diabetes, hypertension, or dyslipidemia.23749750
Dyslipidemias, Cardiovascular Physiological Phenomena, Hyperuricemia, Diabetes MellitusDeregulated Nutrient SensingThe decrease in age-adjusted CSE levels is a potential indicator of eventual cardiovascular dysfunction in medical check-up individuals, as predicted by the risk factors dyslipidemia, hyperuricemia or diabetes.23756406
Dyslipidemias, Retinal DiseasesDeregulated Nutrient SensingDyslipidemia and lipid peroxidation of Saudi type 2 diabetics with proliferative retinopathy.23756927
Diabetic Retinopathy, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and lipid peroxidation may play a role in pathogenesis of diabetic retinopathy.23756927
HyperglycemiaDeregulated Nutrient SensingSurgical stress creates a state of insulin resistance which may contribute to the development of hyperglycemia and, subsequently, postoperative complications.23757474
InflammationDeregulated Nutrient SensingMagnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study.23758216
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur findings suggest that increased magnesium intake was a significant protective factor for the incidence of Type 2 diabetes in the general Japanese population, especially among subjects with insulin resistance, low-grade inflammation and a drinking habit.23758216
Apolipoproteins B, DyslipidemiasDeregulated Nutrient SensingTreatment with glucomannan of children affected by primary dyslipidemia is well-tolerated and effectively lowers total and LDL cholesterol in females and non-high-density lipoprotein cholesterol, but not Apolipoprotein B in both males and females.23759268
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrimary dyslipidemias are major risk factors for cardiovascular disease and should be addressed early in life.23759268
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBecause serum concentrations of soluble forms of TNF-like weak inducer of apoptosis (sTWEAK) and scavenger receptor CD163 (sCD163) have been associated with insulin resistance and type 2 diabetes mellitus (T2D), we tested the associations of sTWEAK and sCD163 with the future development of T2D in elderly subjects at high cardiovascular risk.23760626
InsulitisDeregulated Nutrient SensingIn type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic b -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to b -cell destruction, seems to be the triggering alteration.23762872
Bipolar DisorderDeregulated Nutrient SensingAmong 1950 women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance.23763394
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe most common risk factors were hypertension and dyslipidemia in both groups.23764362
Non-insulin Hypoglycemic, ObesityDeregulated Nutrient SensingAmong children with higher RBP4, the association with obesity increased significantly (from 3.1 to 8.5) in the presence of insulin resistance, when compared to higher RBP4 and non-insulin resistance.23764679
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingStudy consisted of subjects attending the gynecological clinic of Siena or Pisa, with PCOS and insulin resistance, and without contraindications for the use of COCs.23769016
DyslipidemiasDeregulated Nutrient SensingHowever, low SES was linked to increased prevalence and risks of dyslipidemia (P for trend<0.05) and parameters of dyslipidemia in women.23769897
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThese disparities should be considered when performing risk calculations and screening for dyslipidemia, which will ultimately help prevent cardiovascular disease.23769897
Carcinoma of anal canal, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Hypothyroidism, Rheumatoid Arthritis, Obesity, OverweightDeregulated Nutrient SensingAssociated pathology was diabetes mellitus type II (five cases), overweight and obesity (five cases), dyslipidemia (three cases), hypothyroidism (one case), rheumatoid arthritis (one case), external ear canal basal carcinoma (one case).23771077
Dyslipidemias, GAD1 gene, Diabetes MellitusDeregulated Nutrient SensingGAD is often associated with diabetes and dyslipidemia, therefore it is necessary to investigate patients in this direction.23771077
Hyperglycemia, Illness (finding)Deregulated Nutrient SensingThe aim of this trial was to evaluate a subcutaneous insulin algorithm, which incorporates insulin resistance due to individual features and acute illness, for correction of hyperglycaemia in general medical wards.23771784
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingHypertension, dyslipidemia and cardiovascular diseases were significantly more in the patients with abdominal obesity.23773268
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBMI was significantly higher in patients with CAD (27.7 +- 4.3 vs 26.8 +- 4.3 kg/m(2), p < 0.001); these patients were also older, more often male and had higher prevalence of diabetes, hypertension and dyslipidemia.23774273
Inflammation, DyslipidemiasDeregulated Nutrient SensingRecent research has emphasized the strong association between inflammation and both P-wave dispersion and dyslipidemia.23778479
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt is more prevalent with increasing age, in males, in those who smoke, in those with diabetes, and in those with dyslipidaemia.23781540
mecarzole, DyslipidemiasDeregulated Nutrient SensingClinically significant HTG in MBC patients treated with CAP may be associated with pre-existing risk factors, such as dyslipidemia or diabetes-mellitus.23783143
KANTR gene, DyslipidemiasDeregulated Nutrient SensingPatients with moderately/severe spasm were more frequently females, had a history of dyslipidemia, received more often a 7F sheath and more puncture attempts than patients without spasm.23785005
Dyslipidemias, Breast CarcinomaDeregulated Nutrient SensingDyslipidaemia can affect cell integrity in patients of breast cancer.23785924
Diabetes Mellitus, Insulin-Dependent, DyslipidemiasDeregulated Nutrient Sensing[Atherogenic dyslipidemia in patients with type 1 diabetes mellitus].23790581
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingMicrobial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction.23797689
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingIt is hypothesized that microbial translocation may be related to dyslipidemia, insulin resistance, and the risk of coronary heart disease in HIV-infected individuals.23797689
Cardiac complication, Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingHence, the gastrointestinal mucosal barrier may be a potential therapeutic target to prevent dyslipidemia and future cardiovascular complications in HIV infection.23797689
NeoplasmsDeregulated Nutrient SensingEnterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.23799088
polypsDeregulated Nutrient SensingWe crossed APC(+/min) mice with mice bearing enterocyte-specific inactivation of SIRT1 and examined polyp development in the progeny.23799088
NeoplasmsDeregulated Nutrient SensingAdditionally, tumors in SIRT1-deficient mice exhibited markedly increased numbers of cells undergoing apoptosis, suggesting that SIRT1 contributes to tumor growth by enabling survival of tumor cells.23799088
NeoplasmsDeregulated Nutrient SensingOur results indicate that SIRT1 acts as a tumor promoter in the APC(+/min) mouse model of intestinal tumorigenesis.23799088
Communicable Diseases, Hepatitis C, AtherosclerosisDeregulated Nutrient SensingHepatitis C virus (HCV) infection has been linked to an increased risk of insulin resistance and carotid atherosclerosis.23802888
Venous ThromboembolismDeregulated Nutrient SensingBody mass index, a major confounder to insulin resistance association with unprovoked venous thromboembolism.23803721
vinyltriethoxysilaneDeregulated Nutrient SensingThe potential association between insulin resistance and VTE has been poorly evaluated.23803721
vinyltriethoxysilaneDeregulated Nutrient SensingThus, we aimed to assess the association between insulin resistance and VTE in the EDITH hospital-based case-control study.23803721
Inflammation, Obesity, AbdominalDeregulated Nutrient SensingThis dysfunction was best predicted by abdominal obesity, inflammation, glucose-intolerance, and systolic dyssynchrony.23804526
Nerve DegenerationDeregulated Nutrient SensingInhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target.23804751
Skeletal muscle structureDeregulated Nutrient SensingHere we investigated the effects of physical activity level on aging-associated insulin resistance in myotubes derived from human skeletal muscle satellite cells.23805253
Hypopharyngeal CarcinomaDeregulated Nutrient SensingThe Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas.23805287
NeoplasmsDeregulated Nutrient SensingSirtuin 1 (SIRT1) plays an important role in tumorigenesis and is increased in many human tumors.23805287
Hypopharyngeal Squamous Cell CarcinomaDeregulated Nutrient SensingIt is necessary to investigate the expression of SIRT1 and DBC1 in laryngeal and hypopharyngeal squamous cell carcinomas (LSCC and HSCC) and its correlation with available clinical parameters.23805287
NeoplasmsDeregulated Nutrient SensingqRT-PCR assay showed that, compared with the paired adjacent noncancerous mucosae, SIRT1 mRNA was significantly decreased in tumors.23805287
NeoplasmsDeregulated Nutrient SensingThe immunohistochemical results indicated that the SIRT1 protein was also downregulated in tumors compared with noncancerous mucosae.23805287
Neoplasm Metastasis, NeoplasmsDeregulated Nutrient SensingMoreover, decreased SIRT1 was significantly correlated with the tumor clinical stage and lymph node metastasis.23805287
Hypopharyngeal Squamous Cell Carcinoma, Neoplasm MetastasisDeregulated Nutrient SensingSIRT1 and DBC1 might be involved in the pathophysiology of laryngeal and hypopharyngeal squamous cell carcinomas and are associated with lymph node metastasis and p53 positive staining in LSCCs and HSCCs.23805287
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingWith the increase of BMI, the odds ratios (ORs) of high TG, high TC, low HDL-c, high LDL-c and dyslipidemia showed a rising trend (P<0.05), and with the increase of WC, the ORs of high TG, high TC, high LDL-c and dyslipidemia showed a rising trend (P<0.05).23805507
DyslipidemiasDeregulated Nutrient SensingBMI and WC were independently associated with blood lipids levels, and high BMI and WC were the risk factors for dyslipidemia.23805507
DyslipidemiasDeregulated Nutrient SensingCompared with the contrast group, the risk of dyslipidemia significantly increased with increasing average daily alcohol consumption, while ORs were 1.23805522
DyslipidemiasDeregulated Nutrient SensingAlcohol consumption may be a risk factor of dyslipidemia in middle-aged men.23805522
Dyslipidemias, AcromegalyDeregulated Nutrient SensingSmoking (P = 0.007), increased HbA1c levels (P = 0.021), dyslipidaemia (P = 0.049), acromegaly control (P = 0.057), and folate-MTHFR genotype interaction (P = 0.088) were associated with CRT at multivariate analysis.23807201
DyslipidemiasDeregulated Nutrient SensingSmoking, high HbA1c levels, dyslipidaemia and disease activity were also associated with increased CRT risk.23807201
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient Sensing[The detection of leptin and metabolic markers of insulin resistance in patients with myocardial infarction].23808002
Hyperleucinemia, Hyperglycemia, Metabolic Diseases, Myocardial InfarctionDeregulated Nutrient SensingThe identified hyperleptinemia, its relationship with basal and post-prandial hyperglycemia and with increase of C-peptide concentration and free fatty acids made possible to consider leptin both as one of the important components in the series of carbohydrate and lipid metabolism disorders and the additional marker of development of insulin resistance under cardiac infarction.23808002
Coronary Artery Disease, atheroscleroticDeregulated Nutrient SensingInsulin resistance negatively affects long-term outcome in non-diabetic patients with coronary artery disease after therapies to reduce atherosclerotic risk factors.23810069
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance (IR) is a predictor of cardiovascular (CV) events even before the onset of diabetes.23810069
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingComorbidities included dyslipidemia in 129 patients (64.5%) and diabetes in 54 patients (27%).23810299
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingIndividually, diabetes mellitus, hypertension, and dyslipidemia have been shown to increase the risk of cardiovascular disease.23810406
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingWhile traditional management of Type 2 diabetes has focused mainly on glycemic control, robust evidence supports the integration of hypertension and dyslipidemia management to reduce the risk of cardiovascular disease.23810406
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingSeventy-two percent reported comorbid hypertension, dyslipidemia, or both.23810406
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with concurrent type 2 diabetes, hypertension, and dyslipidemia were 6 times more likely to report a prior history of cardiovascular disease compared with those with type 2 diabetes alone.23810406
Diabetic Angiopathies, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes.23811603
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most frequently encountered comorbidities were hypertension (66%), followed by diabetes mellitus (50%) and dyslipidemia (38%).23814777
Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHigher BHB values were independently associated with longer fasting and hyperglycemia, whereas lower values were associated with dyslipidemia and diabetes.23815820
Hypertensive (finding), Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingIn hypertensive patients with moderate dyslipidemia, pravastatin was not superior to usual care in preventing total mortality or CHD independent of baseline eGFR level.23816477
Glucose Intolerance (disease), Heart failure, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAdiponectin levels are inversely correlated to progressing CHD and glucose intolerance but positively correlated to increasing heart failure.23818456
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingAtherogenic dyslipidaemia was more strongly associated with the development of Type 2 diabetes than conventional lipid measurements, and this effect was independent of other well-established risk factor for diabetes.23819613
Hepatitis A, Chronic liver diseaseDeregulated Nutrient SensingInsulin resistance is associated with DNA damage in peripheral blood cells in non-diabetic patients with genotype 1 chronic hepatitis C. In chronic liver diseases of different etiologies, including viral hepatitis, genotoxic effects of oxidative stress have been shown, both in clinical and in experimental conditions, suggesting that this mechanism may contribute to the evolution of the disease.23822095
Hypertension, CTCAEDeregulated Nutrient SensingEssential hypertension (EH) is often accompanied by hyperinsulinemia/insulin resistance (IR) and deranged adiponectin secretion.23822941
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThe 2009 guidelines for the diagnosis and treatment of dyslipidemia were used to define low, moderate or high cardiovascular disease (CVD) risk and treatment initiation and targets.23823891
DyslipidemiasDeregulated Nutrient SensingThere is still a high proportion of Canadians at high risk of CVD, with dyslipidemia, who are not being treated to recommended levels.23823891
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAmong rural and urban settings, 679 patients under continuous care (236 diabetics, 218 with dyslipidaemia, and 225 with hypertension) were consecutively selected by 20 experienced general practitioners.23824265
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt was greater among patients with hypertension and dyslipidaemia and smaller in diabetes care.23824265
Congenital MeSH qualifier, Bartter DiseaseDeregulated Nutrient SensingSix cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR?23824322
Rabson-Mendenhall Syndrome, RMS, Congenital Rubella SyndromeDeregulated Nutrient SensingBiallelic insulin receptor (INSR) gene mutations cause congenital syndromes of severe insulin resistance (SIR) known as Donohue syndrome (DS) and Rabson-Mendenhall syndrome (RMS).23824322
Colorectal CarcinomaDeregulated Nutrient SensingAs insulin resistance (IR) is an established risk factor for colorectal cancer (CRC), we explored the association between each of the IR-related gene polymorphisms of adiponectin (ADIPOQ) rs2241766, uncoupling protein 2 (UCP2) rs659366, and fatty acid-binding protein (FABP2) rs1799883 and CRC risk.23826253
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingThus we reasoned that dyslipidemia-associated nucleotide polymorphisms (SNPs) on the APOA1/C3/A5 gene cluster may predict breast cancer risk and tumor progression.23829168
InflammationDeregulated Nutrient SensingAdipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO).23830287
Metastatic castration-resistant prostate cancerDeregulated Nutrient SensingTemsirolimus blocks mammalian target of rapamycin (mTOR)/target of rapamycin complex 1 (TORC1), a key signaling node in this pathway; its activity in men with advanced castration-resistant metastatic prostate cancer (mCRPC) is unknown.23830964
Demographics Domain, Osage language, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe baseline factors significantly associated with an increased risk for new-onset hypertension were male gender, obesity, diabetes mellitus (DM), dyslipidemia, and OSA.23831239
Inflammation, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Weight decreased, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim was to evaluate the ability of liraglutide to augment weight loss and improve insulin resistance, cardiovascular disease (CVD) risk factors, and inflammation in a high-risk population for type 2 diabetes (T2DM) and CVD.23835684
Weight decreased, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingThe addition of liraglutide to calorie restriction significantly augmented weight loss and improved insulin resistance, systolic blood pressure, glucose, and triglyceride concentration in this population at high risk for development of T2DM and CVD.23835684
InflammationDeregulated Nutrient SensingModels were adjusted for demographics, traditional risk factors, inflammation, insulin resistance and health behaviors.23835937
Deficit, Impaired cognitionDeregulated Nutrient SensingT2DM is associated with cognitive impairment and neural deficits, because of insulin resistance and high expression of insulin receptors in the hippocampus.23835985
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough insulin resistance is usually associated with the development of type 2 diabetes, it can also be a feature of patients with type 1 diabetes.23837272
Diabetes Mellitus, Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance has been documented in type 1 diabetes and may contribute to the high risk of cardiovascular disease in this population.23837272
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTargeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial.23837842
Diabetes Mellitus, Non-Insulin-Dependent, Immune System DiseasesDeregulated Nutrient SensingThe prevalence of type 2 diabetes (T2D) is increasing worldwide and creating a significant burden on health systems, highlighting the need for the development of innovative therapeutic approaches to overcome immune dysfunction, which is likely a key factor in the development of insulin resistance in T2D.23837842
Hepatitis C, ChronicDeregulated Nutrient SensingImpaired mitochondrial b-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance.23841691
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCardiovascular risk factors (CVRFs) includes hypertension, dyslipidemia, diabetes, overweight and smoking.23844099
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPsychological insulin resistance in type 2 diabetes patients regarding oral antidiabetes treatment, subcutaneous insulin injections, or inhaled insulin.23844571
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensing"Psychological insulin resistance" (PIR) is an obstacle to insulin treatment in type 2 diabetes, and patients' expectations regarding alternative ways of insulin delivery are poorly understood.23844571
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingLipid accumulation product and insulin resistance in Iranian PCOS prevalence study.23844634
Inflammation, Dyslipidemias, Lower Urinary Tract SymptomsDeregulated Nutrient SensingDyslipidemia and chronic inflammation may play a role in the cause of lower urinary tract symptoms (LUTS) in older men.23847173
Hyperglycemia, Pancreatic carcinomaDeregulated Nutrient SensingHyperglycemia, insulin resistance, impaired pancreatic b-cell function, and risk of pancreatic cancer.23847240
Hyperglycemia, Structure of beta Cell of isletDeregulated Nutrient SensingThese associations may be secondary to consequences of peripheral insulin resistance, pancreatic b-cell dysfunction, or hyperglycemia itself.23847240
Hyperglycemia, Structure of beta Cell of isletDeregulated Nutrient SensingHemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic b-cell dysfunction.23847240
Hyperglycemia, Structure of beta Cell of islet, Pancreatic carcinomaDeregulated Nutrient SensingAmong participants from five large prospective cohorts, circulating markers of peripheral insulin resistance, rather than hyperglycemia or pancreatic b-cell dysfunction, were independently associated with pancreatic cancer risk.23847240
Cardiovascular Diseases, Sleep Apnea Syndromes, Malignant Neoplasms, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity in childhood is associated with a significant number of complications, such as sleep apnea syndrome, insulin resistance and type 2 diabetes, hypertension, cardiovascular disease and some cancers.23848092
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia plays an important role in the provocation of cardiovascular disease.23848231
Lipodystrophy, Werner SyndromeDeregulated Nutrient SensingPartial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.23849162
Lipodystrophy, Werner SyndromeDeregulated Nutrient SensingWe show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase.23849162
Increased insulin levelDeregulated Nutrient SensingTheir oral glucose tolerance tests showed extremely high levels of insulinemia, revealing major insulin resistance.23849162
Ovarian HyperandrogenismDeregulated Nutrient SensingInsulin-resistance linked ovarian hyperandrogenism could also contribute to decreased fertility, and the two patients became pregnant after initiation of insulin-sensitizers (metformin).23849162
Lipodystrophy, Premature aging syndromeDeregulated Nutrient SensingWe show here for the first time that partial lipodystrophy with severe insulin resistance can reveal WRN-linked premature aging syndrome.23849162
Congenital AbnormalityDeregulated Nutrient SensingSince excess weight, glucose abnormalities, and insulin resistance tend to cluster, the individual role insulin resistance may have in habitual shortened sleep is unclear.23849514
Diabetes MellitusDeregulated Nutrient SensingThere appears to be an independent association between habitual shortened sleep and insulin resistance among obese, dysglycemic adults without diabetes.23849514
Chronic heart failureDeregulated Nutrient SensingEffect of High-Intensity interval training versus moderate continuous training on 24-h blood pressure profile and insulin resistance in patients with chronic heart failure.23857036
Heparin-induced thrombocytopeniaDeregulated Nutrient SensingHIT was more effective in improving insulin resistance.23857036
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingACh-positive patients were more likely to be older male smokers with dyslipidemia, to have a family history of ischemic heart disease, and to have a comorbidity of coronary epicardial stenosis than were ACh-negative patients.23858100
DyslipidemiasDeregulated Nutrient SensingAge and dyslipidemia (or lipid profile) were associated with both ICAD and ECAD.23859180
Old ageDeregulated Nutrient SensingSIRT1 exerts a protective effect against vascular senescence.23859249
diabeticDeregulated Nutrient SensingIn streptozotocin-induced diabetic mice, administration of the G. gnemon ethanolic extract increased SIRT1 and decreased endothelial senescence.23859249
Stomach CarcinomaDeregulated Nutrient SensingAssociation between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer.23860205
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingContinuous rise of insulin resistance before and after the onset of puberty in children at increased risk for type 1 diabetes - a cross-sectional analysis.23861173
Diabetes Mellitus, Insulin-Dependent, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Deregulated Nutrient SensingInsulin resistance has been postulated to be linked to the frequent onset of type 1 diabetes (T1D) during puberty.23861173
Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Deregulated Nutrient SensingTo address the question of how insulin resistance develops with age and how this is related to puberty onset, we examined insulin resistance and pubertal development over time in children at increased risk for T1D.23861173
Autoimmune Diseases, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Deregulated Nutrient SensingThere was a constant age-dependent rise of insulin resistance during childhood without observed associations to the onset of puberty or the presence of islet autoimmunity in children at increased risk for T1D.23861173
HyperglycemiaDeregulated Nutrient SensingComplex pathophysiological mechanisms associated with insulin resistance and hyperglycemia are involved in the deleterious effects on osteoblast function and bone formation.23864319
Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe use of antipsychotics can lead to the development of obesity, dyslipidemia, hypertension and hyperglycemia, risk factors for diabetes mellitus type 2 and cardiovascular diseases.23864411
Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingRegarding NCDs, their prevalence of hypertension was 32.8 %, diabetes 11.4 %, dyslipidemia 16.4 %, overweight 51.1 %, obesity 25.7 % and abdominal obesity 57.8 %.23864429
Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Liver CirrhosisDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis.23864802
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingD-002 (100 mg/day) improved ultrasonographic findings, indicators of insulin resistance, plasma TAS and clinical evolution on NAFLD patients.23864802
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSex, dyslipidemia, smoking and exercise habits were risk factors for CHD alone.23865387
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe risk of CHD in dyslipidemic patients on statin treatment was comparable to the risk in patients without dyslipidemia (HR = 1.134, 95% CI 0.604-2.126).23865387
Dyslipidemias, Hypertension, CTCAE, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThese results suggest the importance of managing dyslipidemia with a statin for primary prevention of CHD, as well as the importance of hypertension therapy.23865387
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a common complication in patients with diabetes and is involved in being prone to cardiovascular disease.23866006
Cardiovascular Diseases, Dyslipidemias, Hyperuricemia, Hua , Hypertension, CTCAEDeregulated Nutrient SensingHyperuricemia (HUA) is a potential risk factor for developing insulin resistance, hypertension, dyslipidemia and cardiovascular disease.23866159
Microvascular Angina, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia and smoking were the most common identifiable risk factors for coronary vascular disease.23866534
Chronic Kidney DiseasesDeregulated Nutrient SensingSome previous observations suggest that insulin resistance and glucose metabolism disturbances are frequent complications of chronic kidney disease.23867834
HD Term TypeDeregulated Nutrient SensingHOMA beta-cell function is strongly correlated with HOMA insulin resistance in HD patients.23867834
Bradyarrhythmia (disorder), Dyslipidemias, Osage languageDeregulated Nutrient SensingA multivariable logistic regression analysis demonstrated that dyslipidemia had the strongest association with a high risk for OSA, but not bradyarrhythmias.23867909
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingResolution of diabetes and dyslipidemia was seen in 85 and 50 % of patients, respectively.23868141
Acute myocardial infarction, AtherosclerosisDeregulated Nutrient SensingInsulin resistance is associated with significant clinical atherosclerosis in nondiabetic patients with acute myocardial infarction.23868937
ObesityDeregulated Nutrient SensingThe prevalence of insulin resistance (IR) is increasing worldwide because of increasing age, obesity, and physical inactivity.23868937
Postoperative PeriodDeregulated Nutrient SensingUse of high-dose remifentanil as intraoperative analgesia during elective gastrectomy reduced postoperative insulin resistance, although it did not reduce postoperative muscle protein catabolism.23869185
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAmong a number of proposed innovative approaches targeting novel pathomechanisms, probiotics appear an interesting and reasonable option acting on gut-liver axis malfunction through the modulation of diet-driven, obesogenic, and inflammatory intestinal microbiota.A combined multiple pharmacological therapy directed simultaneously towards novel and old pathomechanisms (including, e.g., insulin resistance, oxidative stress, gut-liver axis, apoptosis) along with lifestyle interventions however might be necessary both in adult and pediatric NAFLD therapy.23870449
Asp snakeDeregulated Nutrient SensingWe demonstrate elevated mTOR complex 1 (mTORC1) activity in ASPS independent of mTOR complex 2 (mTORC2) activation.23871289
Hyperglycemia, Obesity, AbdominalDeregulated Nutrient SensingOlder people with central obesity, hyperglycemia, insulin resistance and severe antioxidant status tended to have shorter telomere length.23873360
Failure (biologic function)Deregulated Nutrient SensingIn AAs, high LF was associated with a 49% lower SI (P < .001), was not associated with an increase in AIR (P = .25), and was associated with a 42% lower DI (P < .01), indicating failure of compensatory insulin secretion/clearance in response to insulin resistance.23873990
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe age-and gender-standardized prevalence of diabetes mellitus and glucose intolerance were 7.1% (3.6% for undiagnosed) and 8.8% in adults aged >= 25 years, respectively, and increasing with age.23874667
Glucose Intolerance (disease), Smoking, Diabetes MellitusDeregulated Nutrient SensingSmoking had a protective effect for diabetes, drinking had a positive association with diabetes mellitus and glucose intolerance.23874667
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus and glucose intolerance are common in rural adults of southwest China by international standards.23874667
Hypertension, CTCAEDeregulated Nutrient SensingAmong adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations.23877060
Sleep Apnea, Obstructive, Demographics Domain, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingCurrent evidence supports an association between Obstructive Sleep Apnea Syndrome (OSAS), insulin resistance, type 2 diabetes mellitus (DM) and cardiovascular disorders.23877859
Increased insulin level, Inflammation, Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingThe mechanisms through which diabetes is assumed to promote oncogenesis include insulin resistance and associated hyperinsulinemia, hyperglycemia, and inflammation.23879470
DyslipidemiasDeregulated Nutrient SensingThe egg-eating category was inversely associated with dyslipidemia (p < 0.05) but not with the other cardiovascular risk factors.23880191
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingAbdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study.23880198
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingThe relative importance of insulin resistance and hyperglycemia to the development of atherosclerosis remains unclear.23880198
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingOur aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis.23880198
Hyperglycemia, AtherosclerosisDeregulated Nutrient SensingIn middle-aged individuals, we observed similar contributions of insulin resistance and hyperglycemia to subclinical atherosclerosis.23880198
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, HypothyroidismDeregulated Nutrient SensingThe most common comorbidities found in our population were hypertension (35%), diabetes mellitus (20%), hypothyroidism (7%) and dyslipidemia (7%).23882973
STK11 protein, human, BiomechanicsDeregulated Nutrient SensingLinked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes.23883619
Degenerative polyarthritisDeregulated Nutrient SensingAMPK activity is decreased in human knee osteoarthritis (OA) chondrocytes.23883619
Degenerative polyarthritisDeregulated Nutrient SensingBoth LKB1 and AMPK activity were decreased in mouse knee OA and aged knee cartilage, and in bovine chondrocytes after biomechanical injury.23883619
Degenerative polyarthritisDeregulated Nutrient SensingConcurrent loss of LKB1 and AMPK activity in articular chondrocytes is associated with OA, aging and biomechanical injury.23883619
Degenerative polyarthritisDeregulated Nutrient SensingConversely, pharmacologic AMPK activation attenuates catabolic responses to biomechanical injury, suggesting a potentially novel approach to inhibit OA development and progression.23883619
AtherosclerosisDeregulated Nutrient SensingLongitudinal decline of b-cell function: comparison of a direct method vs a fasting surrogate measure: the Insulin Resistance Atherosclerosis Study.23884776
AtherosclerosisDeregulated Nutrient SensingThe Insulin Resistance Atherosclerosis Study is a multicenter, observational, epidemiologic study.23884776
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRole of insulin resistance and adipocytokines on serum alanine aminotransferase in obese patients with type 2 diabetes mellitus.23884827
Hypertransaminasaemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim of our study was to study the association of insulin resistance expressed by HOMA and adipokines in obese type 2 diabetic patients with or without hyper-transaminasemia.23884827
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingForty-two metabolites from three major fuel sources (carbohydrates, lipids, and proteins) were found to significantly correlate with T2D after adjusting for multiple testing; of these, 22 were previously reported as associated with T2D or insulin resistance.23884885
Cardiovascular Diseases, Atherosclerosis, Cerebrovascular accident, Weight Gain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn addition, both weight gain and aging can lead to similar clinical outcomes such as insulin resistance, cardiovascular disease, type 2 diabetes mellitus, atherosclerosis and stroke.23886751
Hypertension, CTCAE, Dysglycemia, DyslipidemiasDeregulated Nutrient SensingOn multiple linear regression analysis, elevated serum FGF21 level in women was an independent risk factor for increased carotid IMT (P=0.039), together with age (P<0.001) and hypertension (P=0.011), in a model comprising also waist circumference, smoking history, serum creatinine, high sensitive C-reactive protein, dysglycemia, and dyslipidemia (adjusted R(2)=35.8%; P<0.001).23887638
Dyslipidemias, Hypertension, CTCAE, Osteoporosis, FractureDeregulated Nutrient SensingMale gender was found to be an independent risk factor for dyslipidaemia, severity of hypertension, lumbar osteoporosis and fractures.23889360
Hypertensive disease, Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThis study explores the prevalence of herbal medicine use in a cohort of patients with chronic kidney disease (CKD), dyslipidemia and hypertension (HTN) in Jordan.23890462
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingA total of 700 CKD, dyslipidemia and hypertension patients were interviewed.23890462
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe majority of patients in this group had hypertension (n = 44, 83.0%), followed by dyslipidemia (n = 32, 60.4%).23890462
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThis study confirmed that there is an appreciable prevalence of herbal use among patients with CKD, dyslipidemia and hypertension in Jordan.23890462
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingInsulin resistance and fasting plasma glucose in first degree relatives of patients with type 1 diabetes.23890682
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingOur results suggest that taking into account the impact of age and BMI on insulin sensitivity, it would be expected that the relatives of patients with type 1 diabetes with "high-normal" glucose levels would become gradually unable to compensate for increasing insulin resistance.23890682
Dyslipidemias, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with chronic kidney disease (CKD) often have mixed dyslipidemia and high cardiovascular disease risk.23891363
TG gene, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThe data suggest that, after 16 weeks of therapy, FA + R has an acceptable safety profile and improved TG and HDL-C efficacy versus R. FA + R combination therapy may thus further improve lipid parameters in patients with stage 3 CKD and mixed dyslipidemia.23891363
Endometrial Serous AdenocarcinomaDeregulated Nutrient SensingOncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).23891627
Impaired cognitionDeregulated Nutrient SensingInsulin resistance possible risk factor for cognitive impairment in fibromialgic patients.23892884
Impaired cognition, Federated States of MicronesiaDeregulated Nutrient SensingTo evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment.23892884
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults.23894289
Respiration DisordersDeregulated Nutrient SensingPrimary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network.23894440
Mitochondrial DiseasesDeregulated Nutrient SensingWe further identify the integrated nutrient-sensing signaling network as a common cellular response that mediates, and may be amenable to targeted therapies for, tissue-specific sequelae of primary mitochondrial RC disease.23894440
Malignant neoplasm of endometriumDeregulated Nutrient SensingInsulin resistance is a well-documented risk factor for the development of endometrial cancer.23896633
Alzheimers Disease", Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging.23897112
Glucose Intolerance (disease), Data types - AddressDeregulated Nutrient SensingIn this prospective cohort with multiple assessments of glucose intolerance and insulin resistance, measures of glucose and insulin homeostasis are not associated with AD pathology and likely play little role in AD pathogenesis.23897112
Ataxia TelangiectasiaDeregulated Nutrient SensingInhibition of DNA damage response by silencing of ataxia telangiectasia mutated (ATM) kinase resulted in upregulation of SIRT1 expression and decreased senescence.23897750
ARCN1 geneDeregulated Nutrient SensingTreatment of BOEC from COPD patients with the SIRT1 activator resveratrol or an ATM inhibitor (KU-55933) also rescued the senescent phenotype.23897750
Hypertensive (finding), Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDespite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high collateralization (for all comparisons, P<0.05).23897789
Periodontal Diseases, Diabetes MellitusDeregulated Nutrient SensingMany clinical studies suggest that periodontal diseases are risk factors for insulin resistance and diabetic mellitus development.23899607
Sleep Disorders, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe increased incidence of impaired glucose tolerance (IGT), are serious public health issues, and several studies link sleeping disorders with increased risk of developing type 2 diabetes, impaired glucose tolerance and insulin resistance (IR).23902570
Hypercholesterolemia, Hypertensive (finding), Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingFrom the 1960s to the 2000s, blood pressure control among hypertensive individuals improved significantly and the smoking rate decreased, but the prevalence of glucose intolerance, hypercholesterolemia, and obesity increased steeply.23902756
Hypertension, CTCAEDeregulated Nutrient SensingAbnormalities in the autonomic nervous system in the presence of insulin resistance may be involved in the pathophysiology of obesity-associated hypertension.23903294
nialamide, ETV3 wt AlleleDeregulated Nutrient SensingNormotensive men with MetS but with EIH have greater insulin resistance as well as lower HRV parasympathetic and sympathetic indices.23903294
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingDominantly inherited mutations cause less severe disease, which may progress to glucose intolerance and diabetes in later life (e.g., SUR1-E1506K).23903354
Glucose Intolerance (disease), Failure (biologic function)Deregulated Nutrient SensingWe conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin secretion due a failure of insulin content to increase with age.23903354
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRelevant comorbidities included diabetes (12 patients), hypertension (23 patients), and dyslipidemia (20 patients).23903461
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingUsing this database, we evaluated the lifestyles of patients with dyslipidemia by identifying risk factors for CHD development based on the JAS recommendations.23903499
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThose who were already being treated for dyslipidemia and had a history of CHD were excluded.23903499
Papillary thyroid carcinomaDeregulated Nutrient SensingAMP-activated protein kinase signaling is upregulated in papillary thyroid cancer.23904275
Thyroid carcinomaDeregulated Nutrient SensingHowever, AMPK signaling pathway in human thyroid carcinomas has not been investigated so far.23904275
Papillary thyroid carcinomaDeregulated Nutrient SensingTo evaluate the expression and activity of AMPK in papillary thyroid carcinomas.23904275
Papillary thyroid carcinoma, CarcinogenesisDeregulated Nutrient SensingOur results show unequivocally that AMPK pathway is highly activated in papillary thyroid carcinomas; however, more studies are necessary to understand the pathophysiological significance of AMPK activation in thyroid carcinogenesis.23904275
Malignant neoplasm of gastrointestinal tractDeregulated Nutrient SensingPeroxisome proliferator-activated receptors (PPAR) are implicated in pathogenesis of insulin resistance and cancers of the digestive system.23907334
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingAssociation of clinical and therapeutic factors with incident dyslipidemia in a cohort of human immunodeficiency virus-infected and non-infected adults: 1994-2011.23909647
DyslipidemiasDeregulated Nutrient SensingMarginal structural modeling suggested a significant association between incident dyslipidemia and exposure to both protease inhibitor- [adjusted rate ratio (aRR)=1.27; CI=1.08-1.49] and non-nucleoside reverse transcriptase inhibitor- (aRR=1.78; CI=1.19-2.66) based cART regimens.23909647
Dyslipidemias, Diabetes Mellitus, Hepatitis C, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingPre-existing hypertension, obesity, and diabetes increased the risk of dyslipidemia, whereas hepatitis C virus, lower CD4(+) T cell count, and higher HIV viral load had a protective effect.23909647
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingIncident dyslipidemia is lower in the early stages of HIV infection, but may significantly increase with cumulative exposure to cART.23909647
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingThiamine deficiency and its correlation with dyslipidaemia in diabetics with microalbuminuria.23914634
Microalbuminuria, DyslipidemiasDeregulated Nutrient SensingTo measure and correlate the levels of thiamine and dyslipidaemia in microalbuminuric diabetics.23914634
Primary malignant neoplasm, Diabetes MellitusDeregulated Nutrient SensingThese results may be environmentally important, in view of the central roles played in human physiology by ATPS and AMPK, particularly in their links to diabetes, cancer and longevity.23915261
Increased insulin level, HyperglycemiaDeregulated Nutrient SensingHyperglycemia, hyperinsulinemia, insulin resistance, and the risk of BPH/LUTS severity and progression over time in community dwelling black men: the Flint Men's Health Study.23915515
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingHigher IAAT was positively associated with increased dyslipidemia (p = 0.001), MS (p = 0.013) and NAFLD (p = 0.005).23919592
Cessation of life, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia is one of several known risk factors for coronary heart disease, a leading cause of death in Lithuania.23919842
square decimeterDeregulated Nutrient SensingChromium supplementation could be beneficial in patients with DM2 treated with insulin, most likely due to lowered insulin resistance leading to improved glucose tolerance.23921483
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Heart failureDeregulated Nutrient SensingMortality increased 3.7-fold with ST-elevation myocardial infarction (STEMI) and 3.0-fold with heart failure (HF) but decreased by 33% with dyslipidemia.23921507
Dyslipidemias, Obesity, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingIn- and peri-hospital mortality in ACS is significantly associated with age, gender, STEMI, HF, and dyslipidemia but not obesity measures.23921507
Obesity, Diabetes MellitusDeregulated Nutrient SensingWe conclude that vitamin D deficiency is a potential risk factor for obesity and development of insulin resistance leading to diabetes type 2.23924693
Weight decreased, Morbid obesityDeregulated Nutrient SensingAdipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity.23928404
Weight decreasedDeregulated Nutrient SensingWeight loss resulted in a significant induction of SIRT1, SIRT3, and SIRT6 expression in the subcutaneous adipose tissue.23928404
Weight decreasedDeregulated Nutrient SensingIn the liver, a significant increase after weight loss was observed, particularly for SIRT3 and SIRT6 mRNA expression; immunohistochemically, SIRT1 and SIRT3 expression was upregulated.23928404
Tumor necrosisDeregulated Nutrient SensingEndotoxin and tumor necrosis factor-alpha suppressed SIRT1, SIRT3, and SIRT6 expression in human monocytes.23928404
Diabetes MellitusDeregulated Nutrient SensingImprovements were also noted for the diabetes markers fasting glucose (166 versus 131 mg/dl, P<0.05), fasting insulin (26.9 versus 10.4 mU/ml, P<0.05), and insulin resistance (9.6 versus 4.2, P=0.03).23929927
Fibrosis AssessmentDeregulated Nutrient SensingOverall, transaminase activities, insulin resistance index, and hepatic fibrosis markers were significantly improved.23933938
Fibrosis Assessment, Diabetes MellitusDeregulated Nutrient SensingAt baseline, subjects in group R (n = 7) were more likely to have diabetes, insulin resistance, and severe fibrosis compared to those in group NR (n = 10).23933938
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingLower NAFLD activity score and larger decrease of ALT and insulin resistance after treatment were observed in group R compared with group NR.23933938
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, ETV3 wt AlleleDeregulated Nutrient SensingIncreased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance.23935829
Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Hypertriglyceridemia, ObesityDeregulated Nutrient SensingOur data suggest that in Chinese men, elevated SUA is significantly associated with NAFLD, independent of insulin resistance and other metabolic disorders, such as central obesity or hypertriglyceridemia.23935829
Dyslipidemias, Overweight, Obesity, PrehypertensionDeregulated Nutrient SensingFactors as overweight, obesity, dyslipidemia appeared to be major risk factors for pre-hypertension.23937831
NeoplasmsDeregulated Nutrient SensingThe effects of topical rapamycin, an mTOR inhibitor, on mTORC1 and mTOR complex-2 (mTORC2) activities, as well as on tumor growth and migration, were determined.23938603
Neoplasms, Vascular TissueDeregulated Nutrient SensingRapamycin fully inhibited mTORC1 and partially inhibited mTORC2 activities, including the phosphorylation of Akt (serine 473) and PKCa, in vascular tumor cells.23938603
Arterial StiffnessDeregulated Nutrient SensingDifference in office blood pressure, 24-hour blood pressure, arterial stiffness, endothelial function, cholesterol level, insulin resistance, and b-type natriuretic peptide level during 12 months.23939263
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingPhase 1 to Phase 2: there were improvement on smoking cessation (P=0.019), dyslipidemia (P<0.001), hypertension and physical activity (P<0.001).23939321
Dyslipidemias, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingSex, age, history of cardiovascular disease and/or diabetes mellitus, use of hydrochlorothiazide, and poor therapy adherence were statistically associated with a lack of dyslipidemia control.23939362
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCONCLUSIONS Higher total energy intake was strongly associated with high levels of insulin resistance and may help to explain emerging type 2 diabetes risk in childhood.23939542
Primary malignant neoplasmDeregulated Nutrient SensingThe AMP-activated protein kinase (AMPK) serves as an energy sensor in eukaryotic cells and occupies a central role in linking metabolism and cancer development.23942093
Liver carcinomaDeregulated Nutrient SensingPrognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma.23942093
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingHowever, the phosphorylation status of AMPK and its therapeutic value in human hepatocellular carcinoma (HCC) remain unclear.23942093
Hepatitis B, FAM126A geneDeregulated Nutrient SensingThe phosphorylation status of AMPK (Thr172) was determined by immunoblotting and immunostaining in specimens from 273 patients with HCC (including 253 patients with hepatitis B virus -related HCC).23942093
FAM126A geneDeregulated Nutrient SensingAMPK is dysfunctional in patients with HCC, and low p-AMPK staining is correlated with aggressive clinicopathologic features and poor prognosis.23942093
FAM126A geneDeregulated Nutrient SensingActivation of AMPK by metformin not only inhibited HCC cells growth in vitro and in vivo, but also augmented cisplatin-induced growth inhibition in HCC cells.23942093
FAM126A geneDeregulated Nutrient SensingThese results present novel insight into a critical role of AMPK in HCC progression.23942093
FAM126A geneDeregulated Nutrient SensingAnticancer effects of therapeutic metformin/AMPK activation unravel metformin's potential in treatment of HCC.23942093
Hypertension, CTCAEDeregulated Nutrient SensingThis inverse correlation between the insulin secretion rate and incident hypertension persisted after controlling for baseline insulin resistance, glycaemia and BP (p = 0.007).23942764
Hypertension, CTCAEDeregulated Nutrient SensingA low insulin secretion rate might be a new risk factor for incident hypertension, beyond insulin resistance.23942764
Inflammation, ObesityDeregulated Nutrient SensingMacrophage infiltration into adipose tissue during obesity and their phenotypic conversion from anti-inflammatory M2 to proinflammatory M1 subtype significantly contributes to develop a link between inflammation and insulin resistance; signaling molecule(s) for these events, however, remains poorly understood.23943623
DyslipidemiasDeregulated Nutrient SensingManagement of dyslipidaemia is therefore suboptimal in this important high-risk group in UK standard practice.23944233
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingMechanisms linking liver functions with cardiometabolic risk may involve insulin resistance (IR) and non-alcoholic fatty liver disease.23945039
Acquired Immunodeficiency Syndrome, Dyslipidemias, No metabolic abnormalitiesDeregulated Nutrient SensingIn the current two decades, dyslipidemia and increased blood glucose as metabolic abnormalities are the most common health threats with a high incidence among HIV/AIDS patients on antiretroviral (ARV) treatment.23947428
Hypercholesterolemia, Pancreatitis, Dyslipidemias, HypertriglyceridemiaDeregulated Nutrient SensingThe blood samples highlighted a milky serum and allowed to diagnose an acute pancreatitis associated with a major dyslipidemia: hypertriglyceridemia 11,800 mg/dL and hypercholesterolemia 1195 mg/dL.23948029
Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Cerebral Atherosclerosis, Hypertension, CTCAEDeregulated Nutrient SensingPatients hospitalized with atherosclerotic cerebral ischemia with >= 1 major uncontrolled risk factor for stroke (hypertension, tobacco use, dyslipidemia, diabetes) were eligible to enroll in our study.23948623
DyslipidemiasDeregulated Nutrient Sensing[Cardiovascular risk factors prevalence among patients with dyslipidemia in Colombia].23949503
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe types of dyslipidemia by frequency were: mixed (46.6%), isolated hypercholesterolemia (29.4%) and hypertriglyceridaemia (20.3%).23949503
DyslipidemiasDeregulated Nutrient SensingLipid-modulating treatments for mixed dyslipidemia increase HDL-associated phospholipase A2 activity with differential effects on HDL subfractions.23949918
ETV3 wt AlleleDeregulated Nutrient SensingWe hypothesize that the vegetarian in Buddhism is associated with better metabolic profiles, lower risk for the MetS and insulin resistance (IR).23951247
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSmall, dense LDL particles predict changes in intima media thickness and insulin resistance in men with type 2 diabetes and prediabetes--a prospective cohort study.23951331
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingElevated circulating levels of branched chain and aromatic amino acids (BCAA/AAAs) are associated with insulin resistance and incident type 2 diabetes (T2D).23953891
DyslipidemiasDeregulated Nutrient SensingANA, as monotherapy or co-administered with ATV, produced significant reductions in LDL-C and increases in HDL-C. ANA was generally well tolerated in Japanese patients with dyslipidemia.23958252
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, HyperglycemiaDeregulated Nutrient SensingType 2 diabetes mellitus is characterized by prolonged hyperinsulinemia, insulin resistance, and progressive hyperglycemia.23962874
Inflammation, hepcidinDeregulated Nutrient SensingAlso relations between visfatin and hepcidin, demands for recombinant human erythropoietin (rHuEpo), inflammation, and situations characterized by insulin resistance were evaluated.23964827
Sleep Apnea Syndromes, Glucose Intolerance (disease), Heart failure, Hypertensive (finding), Chronic Kidney DiseasesDeregulated Nutrient SensingSmaller ancillary studies in hypertensive patients suggest a benefit from renal denervation in a variety of conditions such as chronic kidney disease, glucose intolerance, sleep apnoea and heart failure.23965354
Endothelial dysfunction, Angina Pectoris, VariantDeregulated Nutrient SensingCoronary spastic angina is associated with insulin resistance - possible involvement of endothelial dysfunction.23965946
Endothelial dysfunctionDeregulated Nutrient SensingThere is increasing evidence that insulin resistance is associated with endothelial dysfunction.23965946
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAmong the patients, 50.3% were men, 4.0% had Medicaid health insurance, 17.8% had diabetes, 20.9% had dyslipidemia and 42.4% were adherent (MPR >= 80%).23966057
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNonadherent patients (MPR<80%) were younger and more likely to have Medicaid health insurance; they had lower rates of diabetes and dyslipidemia compared with adherent patients.23966057
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Medically Unexplained Symptoms, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingHowever, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained.23967272
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingAssociations of circulating NAMPT levels with cardiovascular disease (CVD) and insulin resistance have been reported.23968400
Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingInsulin resistance (IR) is believed to be the underlying mechanism of metabolic syndrome and type 2 diabetes mellitus (DM).23977034
Data types - AddressDeregulated Nutrient SensingAutopsy brain hippocampal tissues were obtained from controls and patients with AD and Western blots were performed using antibodies against mTOR signaling molecules and RagC, an upstream component of mTOR complex 1 (mTORC1) signaling.23979023
Data types - AddressDeregulated Nutrient SensingOur data indicate that mTORC1, but not mTORC2, was activated in the AD brains and that the level of mTOR signaling activation was correlated with cognitive severity of AD patients.23979023
Alzheimers DiseaseDeregulated Nutrient SensingDifferential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease.23979023
SpondylitisDeregulated Nutrient SensingCorrelation between insulin resistance and serum ghrelin in non-diabetic ankylosing spondylitis patients undergoing anti-TNF-a therapy.23981480
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn patients with low-LDL-C levels, diabetes with atherogenic dyslipidemia might be the key residual risk.23982317
Increased insulin levelDeregulated Nutrient SensingAlthough cross-sectional associations do not prove causality, our findings do suggest that insulin resistance and in particular, hyperinsulinemia, may negatively affect bone strength relative to load.23983216
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingObese children were likely to insulin resistance and dyslipidemia, which are risk factors of cardiovascular diseases.23984682
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingOverweight and obese youths had reduced insulin sensitivity and high prevalence of dyslipidemia.When BMI-SDS elevated up to 1.22 and BMI was higher than 21.67 in boys, dyslipidemia may happen.23984682
Burn Specimen Source Codes, Traumatic injuryDeregulated Nutrient Sensing[Influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma].23985210
Burn Specimen Source Codes, Traumatic injuryDeregulated Nutrient SensingTo discuss the influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma.23985210
Burn Specimen Source Codes, Traumatic injuryDeregulated Nutrient SensingIntensive insulin therapy can alleviate insulin resistance of patients with severe burn or trauma.23985210
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo determine the prevalence and types of persistent dyslipidemia in patients treated with different statins to reduce cardiovascular disease (CVD) risk, as well as to determine the proportion of high risk patients who did not reach the lipid target values and assess cardiologists' further treatment advice for these patients.23986274
HirsutismDeregulated Nutrient SensingInsulin resistance was significantly predicted by BMI, cholesterol, progesterone and presence of hirsutism.23988170
Hirsutism, Prostate Cancer Outcomes Study, PeriodicityDeregulated Nutrient SensingThe metformin therapy significantly improved insulin resistance, imbalance of endocrine hormones, hirsutism and menstrual cyclicity in women with PCOS.23988170
DyslipidemiasDeregulated Nutrient SensingADT-induced changes in body composition are believed to contribute to a reduction in insulin sensitivity and dyslipidemia that contribute to increased cardiovascular risk profile.23989028
hafnium, Ischemic, DyslipidemiasDeregulated Nutrient SensingMost patients with HF have ischaemic aetiology, and therefore should apply the dietary recommendations for patients with dyslipidaemia and high cardiovascular risk.23990230
DyslipidemiasDeregulated Nutrient SensingDyslipidemia was defined according to the NCEP ATP III guidelines.23991608
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe statistically significant related factors of dyslipidemia, including age, female gender, waist circumference, obesity, diabetes mellitus, smoker, current alcohol consumption, and postmenopausal women, were increased (p < 0.05).23991608
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia, based primarily on the presence of hypercholesterolemia and high LDL-C, was elevated in this population.23991608
DyslipidemiasDeregulated Nutrient SensingDevelopment of a policy to prevent dyslipidemia is urgently needed.23991608
Diabetes Mellitus, Obesity, Visceral, Cardiovascular DiseasesDeregulated Nutrient SensingVisceral obesity is associated with insulin resistance, diabetes, and cardiovascular diseases.23992351
Ventricular hypertrophyDeregulated Nutrient SensingAccording to our results, pericardial ghrelin content is negatively influenced by left ventricular hypertrophy and insulin resistance.23994275
Hypertensive disease, Inflammation, Refractory anemiasDeregulated Nutrient SensingHTN in patients with RA is not associated with generalized systemic inflammation or insulin resistance, but is associated with increasing concentrations of homocysteine and leptin.23996293
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingAlso, the achievement rates of the target LDL-C goal suggested by the dyslipidemia treatment guideline of the Korean Society of Lipidology and Atherosclerosis were not different.23998970
Primary malignant neoplasm, Dyslipidemias, Malignant neoplasm of endometriumDeregulated Nutrient SensingGynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic.23999769
Cerebrovascular Disorders, Dyslipidemias, Malignant neoplasm of endometriumDeregulated Nutrient SensingOur report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors.23999769
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn recent years, the number of patients with type 2 diabetes mellitus caused by insulin resistance has continued to increase in Japan.24002894
Coronary Arteriosclerosis, Arteriosclerosis Obliterans, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is considered to be closely related to the risk of cardiovascular diseases and atherosclerotic diseases, represented by arteriosclerosis obliterans (ASO).24002894
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTherefore, improvement of insulin resistance is one of the important strategies in the treatment of type 2 diabetes mellitus.24002894
FAM126A geneDeregulated Nutrient SensingThe human HCC cell lines HepG2 and PLC/PRF/5 were cultured and treated with metformin or 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), an activator of adenosine monophosphate (AMP)-activated protein kinase.24008375
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient Sensing'Obese NAFLD' is associated with multiple changes in TAGs, which can be attributed to obesity/insulin resistance rather than increased liver fat content per se.24009255
Low density lipoprotein increased, DyslipidemiasDeregulated Nutrient SensingLY treatment produced significant improvements in dyslipidemia, including decreases in low-density lipoprotein cholesterol and triglycerides and increases in high-density lipoprotein cholesterol and a shift to a potentially less atherogenic apolipoprotein concentration profile.24011069
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingSimultaneous prediction of hyperglycemia and dyslipidemia in school children in Santa Catarina State, Brazil based on waist circumference measurement.24012695
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingLogistic regression analysis revealed that increased WC was associated with simultaneous hyperglycemia and dyslipidemia after controlling for differences in sex and age (P<0.01 for all).24012695
Primary malignant neoplasm, Leukemia, Myelocytic, AcuteDeregulated Nutrient SensingCancer cells require nutrients and energy to adapt to increased biosynthetic activity, and protein synthesis inhibition downstream of mammalian target of rapamycin complex 1 (mTORC1) has shown promise as a possible therapy for acute myeloid leukemia (AML).24014241
Leukemia, Myelocytic, AcuteDeregulated Nutrient SensingWe show in our current study that glutamine removal inhibits mTORC1 and induces apoptosis in AML cells.24014241
Primary, Genus ErwiniaDeregulated Nutrient SensingWe show that l-ases from both Escherichia coli and Erwinia chrysanthemi profoundly inhibit mTORC1 and protein synthesis and that this inhibition correlates with their glutaminase activity levels and produces a strong apoptotic response in primary AML cells.24014241
Conventional (Clear Cell) Renal Cell CarcinomaDeregulated Nutrient SensingAcetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients.24018803
Breast Cancer Cell, Breast CarcinomaDeregulated Nutrient SensingRecently, the important role of silent mating type information regulation 2 homolog 1 (SIRT1) and deleted in breast cancer 1 (DBC1) in human cancer has been extensively studied and their role has been closely related with the control of P53 and androgen receptor (AR) functions.24018803
Refractory anemias, Rheumatoid Arthritis, Chronic inflammatory disorderDeregulated Nutrient SensingRheumatoid arthritis (RA), a chronic inflammatory disease, is associated with insulin resistance.24020899
Refractory anemias, InflammationDeregulated Nutrient SensingTherefore, we examined the hypothesis that pioglitazone, a thiazolidinedione peroxisome proliferator-activated receptor g agonist, would decrease inflammation and disease activity and improve insulin resistance in patients with RA.24020899
Refractory anemias, DiseaseDeregulated Nutrient SensingAddition of pioglitazone to RA therapy improves insulin resistance and modestly reduces RA disease activity measured by DAS28-CRP and two of its components, including patient-reported global health and CRP, but not DAS28-ESR or ESR.24020899
Dental PlaqueDeregulated Nutrient SensingInsulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis.24022065
AtherosclerosisDeregulated Nutrient SensingPrevious studies have reported that insulin resistance plays an important role in the progression of atherosclerosis.24022065
Dental PlaqueDeregulated Nutrient SensingHowever, the relationship between insulin resistance and coronary plaque instability is not well established.24022065
Dental PlaqueDeregulated Nutrient SensingThis study suggests that insulin resistance might be associated with coronary plaque vulnerability.24022065
DyslipidemiasDeregulated Nutrient SensingFrom the multivariate stepwise analysis, independent risk factors for annual mortality were male gender (OR = 3.432; p = 0.043), left ventricular systolic dimension (OR = 1.871; p = 0.004) and dyslipidemia (OR = 0.252; p = 0.043).24022323
Dyslipidemias, Cerebral Hemorrhage, Cerebrovascular accidentDeregulated Nutrient SensingIncreasing age, higher National Institutes of Health Stroke Scale score, and history of dyslipidemia were associated with symptomatic intracerebral hemorrhage.24024962
Acanthosis NigricansDeregulated Nutrient SensingAcanthosis nigricans, an indicator of insulin resistance, was identified in nearly 27% of the student records.24027953
Chronic Kidney Diseases, Ventricular hypertrophyDeregulated Nutrient SensingVitamin D deficiency, insulin resistance, and ventricular hypertrophy in the early stages of chronic kidney disease.24028070
Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingThiazolidinediones (TZDs) - rosiglitazone and pioglitazone - a class of insulin sensitizer for treating type 2 diabetes, have been reported to exhibit neuroprotective effects in preclinical studies and have good effects in the control of blood sugar for diabetic patients with insulin resistance.24029780
ACSM3 gene, Non-insulin Hypoglycemic, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, NEUROD1 wt AlleleDeregulated Nutrient SensingThe MHR was evaluated according to age and gender, adjusted for Hypertension (SAH), dyslipidemia and non-insulin dependent diabetes mellitus (NIDDM).24029962
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia, hypertension and DM did not influence the findings.24029962
ACSM3 gene, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of SAH, dyslipidemia and diabetes mellitus did not influence the results.24029962
Primary malignant neoplasmDeregulated Nutrient SensingClinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1.24035280
NeoplasmsDeregulated Nutrient SensingSIRT1 and p300/CBP, which are considered to be essential histone deacetylases and acetyltransferases, are also considered to be relative to tumorigenesis because they modulate the expression of several tumor suppressor genes.24035280
Primary malignant neoplasmDeregulated Nutrient SensingTherefore, this study investigated the expression of SIRT1 and p300/CBP in gastroesophageal junction (GEJ) cancer and their correlation with E-cadherin and MLH1 in order to explore the clinicopathological significance of SIRT1 and p300/CBP expression and their possible effects involving E-cadherin and MLH1 expression.24035280
Neoplasm MetastasisDeregulated Nutrient SensingThe results showed that the over-expression of SIRT1 was associated with a higher number of metastasis lymph nodes, more advanced staging, and shorter mean survival time.24035280
Primary malignant neoplasmDeregulated Nutrient SensingSIRT1 and p300/CBP were negatively and positively correlated with the expression of E-cadherin and MLH1, respectively, in the cancer cases.24035280
NeoplasmsDeregulated Nutrient SensingThese results indicated a possible effect of SIRT1 and p300/CBP involved in regulating the expression of E-cadherin and MLH1, thus participating in the tumor progression of GEJ cancer.24035280
GDC AJCC Clinical Stage Terminology, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingUnder an additive model, the "AA" genotype was associated with an increased risk of developing ACS, adjusted for gender, hypertension, dyslipidemia, alcohol consumption, smoking, and diabetes (OR=1.56, p=0.045).24035903
Retinal Degeneration, Inflammation, methyldopaDeregulated Nutrient SensingOur findings suggest a protective role for SIRT1 signaling in Ab-dependent retinal degeneration and inflammation in AMD.24036938
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMetabolically healthy subjects were free from hypertension, dyslipidaemia, impaired glucose regulation and insulin resistance.24039900
ObesityDeregulated Nutrient SensingHMW adiponectin was positively correlated with HDL cholesterol and negatively correlated with triglycerides, obesity, insulin resistance and blood glucose.24039900
OverweightDeregulated Nutrient SensingA-FABP and its association with atherogenic risk profile and insulin resistance in young overweight and obese women.24044564
Weight decreasedDeregulated Nutrient SensingThere was a statistically significant correlation between change in waist circumference and change in insulin resistance (P<0.02), and between HbA1c and weight loss (P<0.002).24044780
Increased insulin levelDeregulated Nutrient SensingSubjects with FHT2D showed a higher prevalence of hyperinsulinemia and insulin resistance (IR) than those without FHT2D (14.4 vs. 5.7%, p = 0.029, and 14.2 vs. 7.0% p = 0.050, respectively).24051035
Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingLipocalin-2 has been recently identified as an adipokine present in the circulation, it is related to insulin resistance, obesity, atherosclerotic diseases and type 2 diabetes.24052155
Albuminuria, Carotid Intima-Media ThicknessDeregulated Nutrient SensingAlbuminuria was significantly associated with increased Framingham Risk Score (P=.002), insulin resistance by HOMA-IR (P=.02), diastolic blood pressure (P=.01), and carotid intima-media thickness (P =.04).24052917
Glucose Intolerance (disease), Blood GlucoseDeregulated Nutrient SensingIn fact, in DexHmb rats, there was increased fasting glycemia and exacerbated glucose intolerance with the main effect attributed to DEX treatment (p < 0.05).24053521
Glucose Intolerance (disease)Deregulated Nutrient SensingIn fact, the data suggest that HMB may exacerbate GC-induced glucose intolerance.24053521
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingThe combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro.24054871
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingTo examine the ability of dual mTORc1/c2 inhibitors in conjunction with lapatinib to function in a synergistic manner to inhibit cell proliferation and anchorage-independent growth in bladder cancer cell lines.24054871
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingThree bladder cancer cell lines, T24, HT1376, and UM-UC-3, were analyzed for cell proliferation after treatment with mTORc1/c2 inhibitors OSI-027 or PP242.24054871
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe Enhanced Fitness trial enrolled overweight/obese (body mass index >25) sedentary patients with glucose intolerance but without overt diabetes.24055327
Dyslipidemias, Kidney Failure, Cerebrovascular accidentDeregulated Nutrient SensingAtherogenic dyslipidemia and renal insufficiency are suggested to be early predic.tors for stroke and should be closely monitored in Saudi HF patients.24060720
Prediabetes syndrome, Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingTwenty to thirty percent of obese youth have "prediabetes," a precursor to diabetes marked by insulin resistance, b-cell dysfunction, and impaired glucose tolerance.24062325
diabeticDeregulated Nutrient SensingBlood viscosity (BV) is higher in diabetic patients and might represent a risk factor for the development of insulin resistance and type 2 diabetes.24062332
Weight decreased, Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient SensingWe found that despite significant weight loss, improvements in cardiovascular risk factors (dyslipidemia and obstructive sleep apnea), and quality of life in our patients, bariatric surgery does not necessarily lead to improved glycemic control of T1DM.24062368
Fatty degenerationDeregulated Nutrient SensingMedDietScore was negatively correlated to patients' serum alanine aminotransferase (p = 0.03) and insulin levels (p = 0.001), insulin resistance index (p = 0.005) and severity of steatosis (p = 0.006) and positively to serum adiponectin levels (p = 0.04).24064253
Hepatobiliary Disorder, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHigher adherence to the Mediterranean diet is not associated with lower likelihood of having NAFLD, but it is associated with less degree of insulin resistance and less severe liver disease among patients with NAFLD.24064253
Thrombosis, Ventricular Dysfunction, Left, Atherosclerosis, Dyslipidemias, Endothelial dysfunction, Cardiac ArrhythmiaDeregulated Nutrient SensingLow T has been linked to increased blood pressure, dyslipidemia, atherosclerosis, arrhythmia, thrombosis, endothelial dysfunction, as well as to impaired left ventricular function.24064693
Cardiovascular DiseasesDeregulated Nutrient SensingSex differences in insulin resistance and cardiovascular disease risk.24064694
ETV3 wt AlleleDeregulated Nutrient SensingMetS had no impact on CIMT in morbid obese individuals possibly due to established insulin resistance earlier than MetS.24065221
ObesityDeregulated Nutrient SensingIn obesity, elevated insulin resistance is observed, which may be associated with disturbances in mineral status in the body.24065235
Malignant neoplasm of esophagusDeregulated Nutrient SensingFast-track surgery improves postoperative clinical recovery and reduces postoperative insulin resistance after esophagectomy for esophageal cancer.24068549
Malignant neoplasm of esophagusDeregulated Nutrient SensingThis study aims to investigate the influence of fast-track surgery (FTS) on insulin resistance indicators in a prospective randomized, controlled clinical trial in esophageal cancer patients.24068549
Malignant neoplasm of esophagusDeregulated Nutrient SensingFTS promotes early recovery of gastrointestinal function and reduces stress reaction and postoperative insulin resistance after esophagectomy for esophageal cancer.24068549
DyslipidemiasDeregulated Nutrient SensingMarked insulin resistance and the associated dyslipidaemia are not clinical features of HNF1A-MODY carriers.24069322
Diabetes MellitusDeregulated Nutrient SensingHigher levels of monocyte CD36 and plasma CD36(sCD36) are seen to cluster with insulin resistance and diabetes.24069322
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingElevated expression of eukaryotic protein synthesis initiation factor 4E (eIF4E) in histologically cancer-free margins of resected head and neck squamous cell carcinomas (HNSCCs) is mediated by mammalian target of rapamycin complex 1 (mTORC1) and has been associated with increased risk of disease recurrence.24074921
Primary malignant neoplasmDeregulated Nutrient SensingPreclinically, inhibition of mTORC1 with everolimus sensitizes cancer cells to cisplatin and radiation.24074921
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingThe regimen merits further evaluation, especially among patients who are status post resection of HNSCCs that harbor mTORC1-mediated activation of eIF4E in histologically negative surgical margins.24074921
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPolymorphisms in the CNR1 gene (encoding CB1 receptor) were previously found to be associated with dyslipidemia and cardiovascular diseases.24075694
diabeticDeregulated Nutrient SensingIn diabetics, PWV did not correlate with MAP, suggesting that other structural alterations, resulting from insulin resistance, may account for diabetic arterial stiffening to a greater extent than, and independently of, blood pressure.24075763
Asthma, DyslipidemiasDeregulated Nutrient SensingThe findings of this pilot study suggest a role of LDL in asthma, and advocate for larger studies to confirm the association between asthma and dyslipidemia.24075885
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingCaucasians and African immigrants in France had lower HbA1c values than Africans in Cameroon (P<0.001); they were also more aggressively treated for hypertension and dyslipidaemia and, therefore, had significantly lower blood pressure levels and better lipid profiles.24076360
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum IL-18 and hsCRP correlate with insulin resistance without effect of calcitriol treatment on type 2 diabetes.24076594
diabeticDeregulated Nutrient SensingTo investigate the association between insulin resistance and inflammatory markers, and assessing the effects of oral Calcitriol on inflammatory cytokines in type 2 diabetic patients.24076594
Inflammation, diabeticDeregulated Nutrient SensingInflammation was associated with insulin resistance in diabetic patients.24076594
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe influence of fenofibrate on lipid profile, endothelial dysfunction, and inflammatory markers in type 2 diabetes mellitus patients with typical and mixed dyslipidemia.24079286
TG gene, Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingPatients present with typical dyslipidemia (predominantly high levels of triglycerides [TG] and low levels of high-density lipoprotein cholesterol [HDL-C]) or mixed hypercholesterolemia (high levels of low-density lipoprotein cholesterol [LDL-C] and TG with low HDL-C).24079286
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe administered micronized fenofibrate (Laboratories Fourneir S.A Dijon, France) daily for 8 weeks to 40 dyslipidemic, type 2 diabetes patients with equal numbers in each arm of the typical or mixed dyslipidemia groups.24079286
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLipid classes and species associated with type 2 diabetes provide support for a number of existing paradigms of dyslipidemia and suggest new avenues of investigation.24086336
Inflammation, Dyslipidemias, DysglycemiaDeregulated Nutrient SensingAltered cardiac function, dysglycemia and dyslipidemia do not seem to be significantly associated with AHR in severely obese subjects in contrast to systemic inflammation.24088331
Pancreatic Ductal AdenocarcinomaDeregulated Nutrient SensingHigh SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma.24088390
Malignant NeoplasmsDeregulated Nutrient SensingSeveral lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target.24088390
ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal AdenocarcinomaDeregulated Nutrient SensingSince data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expression profile and prognostic significance of Sirt1 in vivo as well as cellular effects of Sirt1 inhibition in vitro.24088390
Pancreatic carcinomaDeregulated Nutrient SensingAccordingly, overexpression of Sirt1 led to increased cell viability, while small molecule inhibition led to a growth arrest in pancreatic cancer cells and impaired cell survival.24088390
Pancreatic carcinomaDeregulated Nutrient SensingSirt1 is an independent prognosticator in PDACs and plays an important role in pancreatic cancer cell growth, which can be levered out by small molecule inhibition.24088390
Alzheimers Disease", Dyslipidemias, Data types - AddressDeregulated Nutrient SensingEpidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood.24088526
Sarcopenia, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, sarcopenia showed an association with insulin resistance, diabetes, and MS, in the non-obese population.24088600
Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingOral health conditions have a significant relationship with diabetes mellitus (DM) as well as dyslipidemia.24095848
Degenerative polyarthritis, Nonerosive Arthritis, Dyslipidemias, Metabolic Syndrome XDeregulated Nutrient SensingIndividuals with erosive osteoarthritis (n=80) had an increased risk of metabolic syndrome (2.7; 1.0 to 7.1), notably dyslipidaemia (4.7; 2.1 to 10.6) compared with non-erosive osteoarthritis classed K&L>=3 (n=193).24095935
Degenerative polyarthritis, DyslipidemiasDeregulated Nutrient SensingMetabolic exposures, dyslipidaemia in particular, may be implicated in erosive osteoarthritis.24095935
Increased insulin level, Portal Hypertension, CirrhoticDeregulated Nutrient SensingOcclusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension.24096983
Increased insulin level, Saint Lucia, Liver Dysfunction, Liver CirrhosisDeregulated Nutrient SensingLiver cirrhosis (LC) is often complicated by hyperinsulinemia due to insulin resistance (IR), which is considered to be closely related to shunt formation and impaired liver function.24096983
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCoronary risk factors (ie, hypertension, dyslipidemia, diabetes mellitus, family history, and smoking) were obtained from the patient medical records.24097215
Coronary Stenosis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAccording to multivariable analysis, the factors affecting coronary stenosis were age, gender, dyslipidemia, diabetes mellitus, and the ratio of visceral to subcutaneous fat.24097215
Dyslipidemias, diabeticDeregulated Nutrient SensingThis gene could then be added to a set of genetic markers to identify individuals with an increased risk for developing T2DM and complications associated with dyslipidemia in diabetic patients.24098457
Glucose Intolerance (disease), Pancreatitis, ObesityDeregulated Nutrient SensingObesity and type 2 diabetes--diseases linked to glucose intolerance and insulin resistance--have been positively associated with the risk of acute pancreatitis.24100113
Obesity, Osage languageDeregulated Nutrient SensingPlasma glucose, HbA1c, and insulin resistance were compared according to OSA and obesity status.24101695
Coronary Artery Disease, Angina PectorisDeregulated Nutrient SensingDifferential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study.24103320
Stomach CarcinomaDeregulated Nutrient SensingSIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-kB/Cyclin D1 signaling.24107295
Primary malignant neoplasmDeregulated Nutrient SensingHowever, the function of SIRT1 in cancer remains controversial.24107295
Stomach CarcinomaDeregulated Nutrient SensingHere, the expression and role of SIRT1 in gastric cancer is delineated.24107295
Stomach NeoplasmsDeregulated Nutrient SensingSIRT1 was present in all normal gastric mucosa specimens; however, it was only present in a portion of the matched gastric cancer tumor specimens.24107295
NeoplasmsDeregulated Nutrient SensingIn SIRT1-positive tumors, both mRNA and protein levels were downregulated as compared with the corresponding nonneoplastic tissue.24107295
Negative Regulation of Cell Cycle, Stomach CarcinomaDeregulated Nutrient SensingEctopic expression of SIRT1 inhibited cell proliferation, diminished clonogenic potential, and induced a G1-phase cell-cycle arrest, the effects of which were not apparent when a catalytic-domain mutant form of SIRT1 was introduced, suggesting that SIRT1 functions in gastric cancer are dependent on its deacetylase activity.24107295
Stomach CarcinomaDeregulated Nutrient SensingThis work characterizes SIRT1 status and demonstrates its inhibitory function in gastric cancer development, which involves NF-kB/Cyclin D1 signaling, offering a therapeutic role for SIRT1 activators.24107295
Stomach CarcinomaDeregulated Nutrient SensingThe inhibitory functions of SIRT1, which involve NF-kB/Cyclin D1 signaling, suggest the utility of SIRT1 activators in the prevention and therapy of gastric cancer.24107295
Primary malignant neoplasm, Liver diseases, Dyslipidemias, Coronary heart disease, Diabetes Mellitus, Heart failure, Obesity, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingVariables used in both analyses were hypertension, obesity, diabetes, dyslipidaemia, heart failure, coronary heart disease, renal failure, liver disorders and cancer.24107981
Chronic infectious disease, Hepatitis CDeregulated Nutrient SensingChronic infection with the hepatitis C virus (HCV) is associated with a higher prevalence of insulin resistance compared to the general population.24114816
Steatohepatitis, Fibrosis AssessmentDeregulated Nutrient SensingThe association of insulin resistance, hepatic steatosis and liver fibrosis was also investigated.24114816
Fatty degenerationDeregulated Nutrient SensingInsulin resistance was found in 27 (61%) patients and significant steatosis in 37 (84%) patients.24114816
Fatty degenerationDeregulated Nutrient SensingComparison between patients with HCV genotype 1 and 3 showed insulin resistance in 15 (65%) vs. 12 (57%), respectively (P = 0.81) and steatosis in 19 (83%) vs. 18 (86%), respectively (P = 0.93).24114816
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingComparison between patients with and without insulin resistance showed, respectively, a higher prevalence of significant fibrosis (56% vs. 6%; P = 0.0001), and a higher mean degree of steatosis (1.3 +- 0.72 vs. 0.76 +- 0.56; P = 0.01).24114816
Hepatitis CDeregulated Nutrient SensingPrevalence of insulin resistance was not different between HCV infected patients with genotype 1 vs. 3.24114816
Fibrosis Assessment, Fatty degenerationDeregulated Nutrient SensingNevertheless, independent of HCV genotype, there was a statistically significant relationship between insulin resistance and a higher amount of liver fibrosis and steatosis.24114816
Diabetes MellitusDeregulated Nutrient SensingCentral (truncal) adiposity is associated strongly with insulin resistance and diabetes.24116041
Low Density ArrayDeregulated Nutrient SensingAfter adjustment for conventional cardiovascular risk factors, such as age, waist circumference, smoking history, low-density and high-density lipoprotein cholesterol, triglycerides, systolic blood pressure and insulin resistance, the ORs (95%CI) of the third tertile adiponectin group were 0.42 (0.25-0.72) in men and 0.47 (0.29-0.75) in women.24116054
Dyslipidemias, XerostomiaDeregulated Nutrient SensingTo evaluate the correlation between dyslipidemia in patients with oral dryness and the development of non-specific histopathological findings in their labial salivary gland biopsies.24118379
Dyslipidemias, XerostomiaDeregulated Nutrient SensingThirty seven patients suffering from oral dryness (18 patients with dyslipidemia and 19 age-matched patients with normal lipid blood levels) underwent labial salivary gland biopsy.24118379
Dyslipidemias, Chronic diseaseDeregulated Nutrient SensingMultidisciplinary approaches, such as the chronic care model, have been applied to other chronic diseases and likely would be applicable to the management of dyslipidaemia.24118549
DyslipidemiasDeregulated Nutrient SensingOur study identifies different components of a multidisciplinary approach to management of dyslipidaemia that are efficacious and these results may help guide future investment in this area.24118549
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingMRI-diagnosed nonalcoholic fatty liver disease is correlated to insulin resistance in adolescents.24119357
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingTo evaluate the presence of nonalcoholic fatty liver disease (NAFLD) in eutrophic and obese adolescents with magnetic resonance imaging (MRI) and its relationship to insulin resistance and other potential biomarkers.24119357
Skeletal muscle structureDeregulated Nutrient SensingOur results suggest that sedentary postmenopausal women with an appendicular skeletal muscle mass index above 7.025 kg/m(2) may be at greater risk of insulin resistance.24120357
Communicable Diseases, Hepatitis C, Diabetes MellitusDeregulated Nutrient SensingHepatitis C virus (HCV) infection is causally associated with insulin resistance and diabetes mellitus.24122848
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance is associated with Fibroblast Growth Factor-23 in stage 3-5 chronic kidney disease patients.24125760
Calcification of coronary artery, SLC25A20 gene, Chronic Kidney DiseasesDeregulated Nutrient SensingTo determine the associations between insulin resistance, fibroblast growth factor 23 (FGF-23), and coronary artery calcification (CAC) in chronic kidney disease (CKD) patients.24125760
FGF23 protein, human, Atherosclerosis, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingFGF-23 is associated with atherosclerosis and cardiovascular disease, but its association with insulin resistance in CKD has not been explored.24125760
SLC25A20 gene, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistant CKD patients demonstrated higher FGF-23 levels, and increased CAC, while PO4 levels remained normal, suggesting a potential link between insulin resistance and PO4 homeostasis in CKD.24125760
Prostate carcinoma, NeoplasmsDeregulated Nutrient SensingSIRT1, which may act either as tumor suppressor or oncogene, reduces H2A.Z levels in cardiomyocytes, via proteasome-mediated degradation, and this mechanism might be impaired in prostate cancer cells due to sirtuin 1 downregulation.24127549
CarcinogenesisDeregulated Nutrient SensingThus, we aimed to characterize the mechanisms underlying H2A.Z and SIRT1 deregulation in prostate carcinogenesis and how they interact.24127549
Primary malignant neoplasm, Prostatic Intraepithelial NeoplasiasDeregulated Nutrient SensingWe found that H2AFZ and SIRT1 were up- and downregulated, respectively, at transcript level in primary prostate cancer and high-grade prostatic intraepithelial neoplasia compared to normal prostatic tissues.24127549
Prostate carcinomaDeregulated Nutrient SensingInduced SIRT1 overexpression in prostate cancer cell lines resulted in almost complete absence of H2A.Z.24127549
Prostate carcinomaDeregulated Nutrient SensingRegulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer.24127549
Prostate carcinomaDeregulated Nutrient SensingWe concluded that sirtuin 1 and H2A.Z deregulation in prostate cancer are reciprocally related.24127549
Prostate carcinomaDeregulated Nutrient SensingEpigenetic modifying drugs in conjunction with enzymatic modulators are able to restore the normal functions of sirtuin 1 and might constitute relevant tools for targeted therapy of prostate cancer patients.24127549
ObesityDeregulated Nutrient SensingAdipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro.24130353
Obesity, Visceral, Metabolic Syndrome XDeregulated Nutrient SensingOur data suggest that DPP4 may be a marker for visceral obesity, insulin resistance, and the metabolic syndrome.24130353
Non-alcoholic Fatty Liver Disease, Obesity, Visceral, Diabetes MellitusDeregulated Nutrient SensingTo investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and nonalcoholic fatty liver disease (NAFLD) independent of visceral obesity in Koreans and to examine whether the associations differ according to the presence of diabetes or insulin resistance.24130687
Non-alcoholic Fatty Liver Disease, Obesity, Visceral, Diabetes MellitusDeregulated Nutrient SensingLow vitamin D status is closely associated with NAFLD, independent of visceral obesity in subjects with diabetes or insulin resistance.24130687
Communicable Diseases, InflammationDeregulated Nutrient SensingAlthough markers of inflammation and insulin resistance are also related to the onset of surgical infection, leptin correlates more closely with the risk of infection than does any other factor.24132530
Hypertensive (finding), Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHypertensive patients have higher prevalence of insulin resistance and are at increased risk of developing type 2 diabetes mellitus (DM).24132701
Erectile dysfunctionDeregulated Nutrient SensingActivin A released from epicardial adipose tissue has been linked to contractile dysfunction and insulin resistance in cardiomyocytes.24134550
DyslipidemiasDeregulated Nutrient SensingDepressive symptomatology was significantly associated with high total cholesterol, high triglycerides, low high-density lipoprotein cholesterol (HDL-C), high low-density lipoprotein cholesterol (LDL-C), and dyslipidemia (p < 0.05).24136399
Triglycerides, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Bipolar DisorderDeregulated Nutrient SensingElevated depressive symptoms are associated with lipid profile characterized by high cholesterol, high triglycerides, low HDL-C, high LDL-C, and dyslipidemia; the associations are partially mediated by ischemic heart disease and stroke.24136399
Pancreatic carcinomaDeregulated Nutrient SensingGenetic variations in inflammatory response and insulin resistance may affect the risk of obesity- and diabetes-related pancreatic cancer.24136929
Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia due to diabetes is characterized by hypertriglyceridemia and reduced levels of high-density lipoprotein cholesterol (HDL-C) and elevated or normal levels of low-density lipoprotein cholesterol (LDL-C) in type 2 diabetes mellitus (T2DM).24138536
Cardiovascular Diseases, diabetic, Cerebrovascular accidentDeregulated Nutrient SensingAlthough elevated serum C-peptide level as an indicator of insulin resistance increases the obesity-associated risk of cardiovascular disease among diabetic patients, evidence indicating that serum C-peptide level is associated with stroke in nondiabetic subjects is limited.24139410
Autoimmune Diseases, ObesityDeregulated Nutrient SensingAccordingly, TNF a has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance.24139907
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingAfter adjustment by a stepwise logistic regression method, hypertension, dyslipidemia, and CA+AA genotype were found to be significantly associated with T2D.24139907
NCI CTEP SDC Myelodysplastic Syndrome Sub-Category TerminologyDeregulated Nutrient SensingHigher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome.24140093
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingVariants of estrogen receptor a (ERa) have been associated with obesity, dyslipidemia, diabetes and blood pressure.24140101
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis.24141324
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, AtherosclerosisDeregulated Nutrient SensingWorldwide clinical practice guidelines for dyslipidemia emphasize allocating statin therapy to those at the highest absolute atherosclerotic cardiovascular disease (CVD) risk.24141324
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingWe examined 5534 Multi-Ethnic Study of Atherosclerosis (MESA) participants who were not on baseline medications for dyslipidemia.24141324
SLC25A20 gene, DyslipidemiasDeregulated Nutrient SensingAcross the spectrum of dyslipidemia, event rates similar to secondary prevention populations were observed for patients with CAC >= 100.24141324
AlbuminuriaDeregulated Nutrient SensingRenal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.24141423
Diabetic NeuropathiesDeregulated Nutrient SensingHere we investigated the protective role of Sirt1 in diabetic renal damage.24141423
Albuminuria, diabeticDeregulated Nutrient SensingWe found that Sirt1 in proximal tubules (PTs) was downregulated before albuminuria occurred in streptozotocin-induced or obese (db/db) diabetic mice.24141423
Albuminuria, Diabetes MellitusDeregulated Nutrient SensingPT-specific SIRT1 transgenic and Sirt1 knockout mice showed prevention and aggravation of the glomerular changes that occur in diabetes, respectively, and nondiabetic knockout mice exhibited albuminuria, suggesting that Sirt1 in PTs affects glomerular function.24141423
AlbuminuriaDeregulated Nutrient SensingDownregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria.24141423
Proteinuria, Diabetes MellitusDeregulated Nutrient SensingIn human subjects with diabetes, the levels of SIRT1 and Claudin-1 were correlated with proteinuria levels.24141423
Albuminuria, Diabetes MellitusDeregulated Nutrient SensingThese results suggest that Sirt1 in PTs protects against albuminuria in diabetes by maintaining NMN concentrations around glomeruli, thus influencing podocyte function.24141423
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingDifferential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study.24141640
Increase, ObesityDeregulated Nutrient SensingWe show that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin resistance, and protects against age-related obesity.24142699
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe risk factors include insulin resistance, obesity, dyslipidemia, and hypertension and it is known to increase the risk for CVD and type II diabetes.24144655
Units Of Measure - SiemensDeregulated Nutrient SensingPhysical activity was associated with MHO defined by insulin resistance (OR 1.87, 95% CI 1.19-2.92, p = 0.006).24146838
Dyslipidemias, Depression, CTCAE, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingDifferences were observed with respect to concomitant disease/other risk factors (depression, dyslipidemia, cardiovascular disease, hypertension).24150103
Adrenal incidentalomaDeregulated Nutrient SensingRelationship between thyroid nodules and non-functioning adrenal incidentalomas and their association with insulin resistance.24152247
Adrenal incidentalomaDeregulated Nutrient SensingThe relationship between insulin resistance and thyroid nodules in patients with non-functional adrenal incidentalomas (AI) is not clearly understood.24152247
InflammationDeregulated Nutrient SensingThe significant mediating role of low-grade inflammation in the association between the ADII and HOMA-IR suggests that inflammation might be one of the pathways through which diet affects insulin resistance.24153342
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffect of atorvastatin on baroreflex sensitivity in subjects with type 2 diabetes and dyslipidaemia.24154932
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA total of 79 patients with type 2 diabetes with dyslipidaemia were recruited.24154932
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA low dose of atorvastatin increased BRS in non-obese subjects with type 2 diabetes and dyslipidaemia after 1-year treatment.24154932
Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingType 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle.24156295
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingCommon and low-frequency variants in AGPAT6 do not significantly associate with type 2 diabetes susceptibility, or influence related phenotypic traits such as obesity, dyslipidemia or indices of insulin sensitivity or insulin secretion in the population studied.24156295
Dyslipidemias, Injury of cardiac valve, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAfter adjusting for conventional risk factors (age, gender, smoking, diabetes mellitus, dyslipidemia, hypertension), free triiodothyronine (FT3) was significantly and negatively correlated with log-CKMB (r = -0.244, P < 0.001) and log-cTnI (r = -0.290, P < 0.001), indicating that the lower thyroid hormone level correlates with the severer cardiac injury in STEMI patients.24157158
square decimeter, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMexicor promoted combined hypolipidemic effect, reduced the degree of insulin resistance, improved hepatic metabolism, and lowered cardiovascular risks in patients with CHD and DM2.24159791
DyslipidemiasDeregulated Nutrient SensingMexicor was shown to act as a hepatoprotector reducing the frequency of cytolithic syndrome when used together with statins in combined therapy of atherogenic dyslipidemia.24159791
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociations of organochlorine pesticides and polychlorinated biphenyls in visceral vs. subcutaneous adipose tissue with type 2 diabetes and insulin resistance.24161582
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAs OC pesticides and PCBs mainly accumulate in adipose tissue and there are physiological and clinical differences between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), we explored if there were associations of OC pesticides and PCBs in VAT or SAT with type 2 diabetes and insulin resistance.24161582
Diabetes MellitusDeregulated Nutrient SensingSome OC pesticides or PCBs, such as dichlorodiphenyltrichloroethanes (DDTs), chlordanes, and PCBs with 5 or less chlorides showed significant associations with diabetes or insulin resistance.24161582
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNon-calcified plaques were positively associated with male gender, age, dyslipidaemia and diabetes mellitus.24162317
Acute Coronary SyndromeDeregulated Nutrient SensingPlasma gamma-glutamyltransferase is strongly determined by acylation stimulating protein levels independent of insulin resistance in patients with acute coronary syndrome.24167361
Fatty degenerationDeregulated Nutrient SensingMechanisms involved in enhanced hepatic lipogenesis causing steatosis are not yet identified and are usually linked to insulin resistance (IR).24167361
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus.24167545
Inflammation, HaitiDeregulated Nutrient SensingHT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT.24170558
HaitiDeregulated Nutrient SensingHT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters.24170558
Inflammation, HaitiDeregulated Nutrient SensingThese results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT.24170558
Kidney Failure, Chronic, DyslipidemiasDeregulated Nutrient SensingWe describe the prevalence of dyslipidaemia, and potential determinants associated with lipid measures in a large cohort of paediatric ESRD patients.24170813
palladium, HD Term Type, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidaemia was 85.1% in peritoneal dialysis (PD) patients, 76.1% in haemodialysis (HD) patients and 55.5% among renal allograft recipients.24170813
Kidney Failure, Chronic, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia is common among paediatric ESRD patients in Europe.24170813
DyslipidemiasDeregulated Nutrient SensingAlthough lipid levels generally improve after transplantation, dyslipidaemia may persist due to decreased graft function, high BMI or to the use of certain immunosuppressants.24170813
Premature Menopause, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingConsidering the known risk factors in women, dyslipidemia, premature menopause, hypertension, oral contraceptives, diabetes and smoking were regarded as the most common ones.24171269
NeoplasmsDeregulated Nutrient SensingThe related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase.24171924
Overweight, Diabetes MellitusDeregulated Nutrient SensingOlder age, female sex, overweight or obese, high wealth index and positive family history of diabetes were significantly associated with insulin resistance.24172217
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingParticipants with type-2 diabetes or insulin resistance had significantly poorer physical health only if they had associated cardiovascular disease.24172217
ETV3 wt AlleleDeregulated Nutrient SensingWhen lipid categories, hs-CRP, BMI, and insulin resistance levels were taken into account, testosterone lost its significance in predicting MetS (p < 0.20), suggesting that these markers possess a mediating effect.24172696
Glucose Intolerance (disease), diabeticDeregulated Nutrient SensingThe patients were divided on the basis of diabetic criteria for glucose intolerance into 2 groups: the diabetic group (n = 105) and nondiabetic group (n = 400).24173020
PANCREATIC LIPASE DEFICIENCYDeregulated Nutrient SensingThe unimolecular dual incretins corrected two causal mechanisms of diabesity, adiposity-induced insulin resistance and pancreatic insulin deficiency, more effectively than did selective mono-agonists.24174327
Diabetes MellitusDeregulated Nutrient SensingWhether decreased oxidative capacity itself is a cause or consequence of insulin resistance and diabetes is unknown.24176820
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIncreased expression of 11beta-HSD 1 in adipose tissue promotes higher body mass index (BMI), insulin resistance, hypertension, and dyslipidemia.24182335
Thrombus, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is a clinical condition with a relatively high prevalence in the population and has been associated with an increased thrombotic risk.24183115
Thrombosis, Dyslipidemias, vinyltriethoxysilaneDeregulated Nutrient SensingOur study confirmed the association between dyslipidemia and VTE and showed a risk of thrombosis nearly 4 times higher in individuals with this disease.24183115
Breast CarcinomaDeregulated Nutrient SensingWe sought to evaluate the seven sirtuin family members (SIRT1-7) in a human breast cancer cohort, in relation to clinico-pathological features and outcome of the disease.24183459
Mammary NeoplasmsDeregulated Nutrient SensingImmunohistochemical analysis of SIRT1-7 protein levels was undertaken in 392 oestrogen receptor (ER+ve) and 153 ER-ve breast tumour samples.24183459
Degenerative polyarthritisDeregulated Nutrient SensingHowever the role of SIRT1 and SOST in OA Ob remains unknown.24184155
Degenerative polyarthritisDeregulated Nutrient SensingHerein, we explored the role played by SIRT1 and SOST on the abnormal mineralization and cWnt signaling in OA Ob.24184155
Degenerative polyarthritisDeregulated Nutrient SensingSIRT1 expression was significantly reduced in OA Ob compared to normal yet not modified by TGF-b1.24184155
Degenerative polyarthritisDeregulated Nutrient SensingSpecific inhibition of SIRT1 increased TGF-b1 and SOST expressions in OA Ob, while stimulating SIRT1 activity with b-Nicotinamide mononucleotide reduced the expression of TGF-b1 and SOST, and increased mineralization in OA Ob.24184155
Degenerative polyarthritisDeregulated Nutrient SensingThese data indicate that high level of SOST is responsible, in part, for the reduced cWnt and mineralization of human OA Ob, which in turn is linked with abnormal SIRT1 levels in these pathological cells.24184155
Degenerative polyarthritisDeregulated Nutrient SensingLow sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/b-catenin activity.24184155
Pre-EclampsiaDeregulated Nutrient SensingA randomized controlled clinical trial investigating the effect of calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress and insulin resistance in pregnant women at risk for pre-eclampsia.24187901
Pre-EclampsiaDeregulated Nutrient SensingIncreased levels of pro-inflammatory factors, markers of oxidative stress and insulin resistance during pregnancy have been associated with the development of pre-eclampsia.24187901
Pre-EclampsiaDeregulated Nutrient SensingTo our knowledge, no reports are available indicating the effects of consumed calcium supplement plus aspirin on high sensitivity C-reactive protein (hs-CRP), oxidative stress parameters and insulin resistance in pregnant women at risk for pre-eclampsia.24187901
Pre-EclampsiaDeregulated Nutrient SensingThis study was designed to investigate the effects of consumed calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress parameters and insulin resistance among Iranian pregnant women at risk for pre-eclampsia.24187901
Metabolic Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is a common metabolic disorder that may result from abnormalities in the synthesis, processing and catabolism of lipoprotein particles.24188362
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAt baseline, 774 (33%) had diabetes, 1252 (63%) dyslipidemia, and 1601 (68%) hypertension.24189773
ETV3 wt AlleleDeregulated Nutrient SensingThe prevalences of insulin resistance and MetS were calculated.24190050
ETV3 wt AlleleDeregulated Nutrient SensingWC was associated with incident insulin resistance and MetS independent of BMI in both men and women.24190050
ETV3 wt AlleleDeregulated Nutrient SensingNormal-weight individuals with insulin resistance and/or MetS are not rare in the Chinese population.24190050
ETV3 wt AlleleDeregulated Nutrient SensingFat mass is associated with insulin resistance and MetS in normal-weight subjects.24190050
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingTherefore, we investigated the association between serum AFP and insulin resistance in patients with CHC.24190142
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingWhole-body insulin resistance is associated with an elevated serum AFP level in patients with CHC.24190142
Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingLifestyle interventions targeting insulin resistance can reduce the serum AFP level and may ameliorate the clinical course of CHC.24190142
Periodontal Diseases, Diabetes MellitusDeregulated Nutrient SensingThe goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non-smoking adults without manifest diabetes.24192072
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFurther research is needed to determine how racial/ethnic differences in dyslipidemia affect racial/ethnic differences in cardiovascular disease rates.24192801
Dyslipidemias, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingThe most prevalent associated cardiovascular risk factors in the total population were smoking (24.9%), dyslipidemia (16.4%), a family history of premature cardiovascular disease (15.9%), and obesity (7.4%).24192846
Humoral immune defect, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes results from combined insulin resistance and b-cell deficiency.24193809
Renal Insufficiency, Dyslipidemias, Chronic Kidney Diseases, AtherosclerosisDeregulated Nutrient SensingIn addition, because dyslipidemia facilitates atherosclerosis and renal dysfunction, antihyperlipidemic treatment is important to prevent cardiac and renal events in CKD patients.24198051
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffect of a randomised controlled vitamin D trial on insulin resistance and glucose metabolism in patients with type 2 diabetes mellitus.24198221
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIndividuals in the 5th quintile or higher of resistin (RQ5) were younger (P<0.001) and had a lower prevalence of arterial hypertension (P<0.001), abdominal obesity (P<0.001), diabetes (P<0.001) and dyslipidemia (P<0.001).24201007
Inflammation, Diabetes MellitusDeregulated Nutrient SensingLow-grade inflammation in adipose tissue and liver has been implicated in obesity-associated insulin resistance and type 2 diabetes.24203314
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn all, 8, 20, 16, and 9 patients had diabetes mellitus, hypertension, dyslipidemia, and smoking habit, respectively.24203346
Astrocytoma, Glioblastoma Multiforme PathwayDeregulated Nutrient SensingActivation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target.24203892
NeoplasmsDeregulated Nutrient SensingHere we further evaluate the role of the mTORC1/mTORC2 pathway in order to better direct pharmacologic blockade in these common childhood tumors.24203892
Optic Disk, Dyslipidemias, Diabetes Mellitus, Cataract, Retinal Vein OcclusionDeregulated Nutrient SensingIt was not significantly associated with optic nerve head measurements, refractive error, any ocular biometric parameter, nuclear cataract, early age-related macular degeneration and retinal vein occlusion, diabetes mellitus, smoking, and dyslipidemia.24204672
DyslipidemiasDeregulated Nutrient SensingFirst-line management of dyslipidemia among very-high cardiovascular risk outpatients in Western Greece is unsatisfactory, with the majority of treated individuals failing to attain the LDL-C and non-HDL-C targets.24209409
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIn obese patients with uncomplicated dyslipidemia and hypertension, plasma S1P was increased compared with that in nonobese and lean individuals.24212262
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEffect of laparoscopic Roux-en-Y gastric bypass on body composition and insulin resistance in Chinese patients with type 2 diabetes mellitus.24214201
Dyslipidemias, diabeticDeregulated Nutrient SensingImportance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events.24215618
Dyslipidemias, Cerebrovascular accident, Myocardial Ischemia, diabeticDeregulated Nutrient SensingThe risk factors for ischemic heart disease (IHD) or cerebrovascular accident (CVA) in elderly diabetic individuals with type IIb dyslipidemia are not fully known.24215618
Dyslipidemias, Cerebrovascular accident, Myocardial Ischemia, diabeticDeregulated Nutrient SensingTherefore, we investigated the relationship between lipid levels and IHD and CVA in diabetic individuals with type IIb dyslipidemia.24215618
Dyslipidemias, diabeticDeregulated Nutrient SensingHigh-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol/HDL-C were significantly associated with the risk of cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <65 years, and HDL-C and diastolic blood pressure was significantly associated with cardiovascular events in patients aged 65-74 years.24215618
Dyslipidemias, diabeticDeregulated Nutrient SensingMultiple regression analysis showed that lower HDL-C was significantly associated with the risk of cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <65 years and 65-74 years.24215618
Dyslipidemias, diabeticDeregulated Nutrient SensingLower HDL-C was an important risk factor for cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <75 years.24215618
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance.24215793
Diabetes MellitusDeregulated Nutrient SensingOur data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of a-cells are potential contributors to the b-cell compensatory response to insulin resistance in the absence of overt diabetes.24215793
DyslipidemiasDeregulated Nutrient SensingLow vitamin D levels correlate with dyslipidemia, but limited data exist on indigenous children.24217313
Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with pre-diagnosed metabolic disorders, especially dyslipidemia and type 2 diabetes, should undergo regular controls of serum triglycerides during tamoxifen treatment.24221976
Metabolic Diseases, DyslipidemiasDeregulated Nutrient SensingHowever, the awareness rate of cardiometabolic diseases was low, especially for dyslipidemia.24222736
Nonalcoholic Steatohepatitis, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver DiseaseDeregulated Nutrient SensingPatients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) often have metabolic disorders including insulin resistance and type 2 diabetes mellitus (T2DM).24223115
Fibrosis AssessmentDeregulated Nutrient SensingThe proportion of patients with T2DM significantly gradually increased, HbA1c and the homeostasis model assessment of insulin resistance were significantly elevated, and 1,5-anhydroglucitol (1,5-AG) was remarkably decreased with the progression of fibrosis.24223115
DyslipidemiasDeregulated Nutrient SensingAssociation of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.24223837
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSimilar results were obtained in each subgroup of patients with hypertension, dyslipidemia, or diabetes mellitus.24225305
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThe ameliorating effect of a-GI on post-prandial hyperglycemia without stimulating insulin secretion may improve atherogenic dyslipidemia by reducing insulin resistance.24225338
HyperglycemiaDeregulated Nutrient SensingRice and noodle consumption is associated with insulin resistance and hyperglycaemia in an Asian population.24229726
Hyperglycemia, InflammationDeregulated Nutrient SensingThese results suggest that high consumption of rice and noodles may contribute to hyperglycaemia through greater insulin resistance and that this relationship is independent of adiposity and systemic inflammation.24229726
Stomach CarcinomaDeregulated Nutrient SensingInfluence of early enteral nutrition (EEN) on insulin resistance in gastric cancer patients after surgery.24231013
Stomach CarcinomaDeregulated Nutrient SensingTo evaluate the benefits of reducing insulin resistance by early enteral nutrition (EEN) in gastric cancer patients after surgery.24231013
Stomach CarcinomaDeregulated Nutrient SensingThe management of EEN can alleviate insulin resistance in gastric cancer patients with surgical treatment.24231013
Obesity, Abdominal, Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingHyperuricemia is prevalent in Chinese T2DM patients with central obesity and is significantly positively associated with women, cardiovascular risk factors such as obesity, hypertension and dyslipidemia, and low eGFR.24231020
Inflammation, ObesityDeregulated Nutrient SensingEffect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children.24232638
NeoplasmsDeregulated Nutrient SensingWe suggest that these tumours may arise through a mechanism involving ATP depletion, activation of AMPK, and induction of cyclin D1, and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours.24236567
ObesityDeregulated Nutrient SensingIn animal studies, monosodium glutamate (MSG) intake at a particular age has been found to increase the risk of insulin resistance and obesity.24238788
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingMultiple logistic regression analysis showed that the largest risk factor for ACS development was given by smoking (11.88-fold increased risk), hypertension (4.32-fold increased risk), type II diabetes (3.44-fold increased risk), gender (2.32-fold increased risk), and dyslipidemia (1.52-fold increased risk).24239012
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOnly one patient had diabetes and 10 (15.4%) had dyslipidemia.24239395
Dyslipidemias, Obesity, Behavior DisordersDeregulated Nutrient SensingMeasures aimed at combating obesity and other lifestyle-related risk factors are also vital for effectively controlling dyslipidaemia and reducing the burden of CVD.24240385
DyslipidemiasDeregulated Nutrient SensingCholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol.24240543
TG gene, Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingAtherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases.24240543
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingSIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin.24240701
Metabolic Diseases, Primary malignant neoplasmDeregulated Nutrient SensingAlthough SIRT1 contributes to aging and metabolic disorders, its role in cancer progression and therapeutic responses remains controversial.24240701
Non-Small Cell Lung Carcinoma, HypoxiaDeregulated Nutrient SensingSIRT1 was downregulated in a panel of non-small cell lung carcinoma (NSCLC) cells exposed to hypoxia for 48 hours.24240701
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe shortest distance in the receiver operating characteristic curves for hypertension, dyslipidemia, diabetes, or >= 2 of these risk factors suggested a BMI cutoff of 26 and a waist circumference cutoff of 90 cm for both men and women.24244645
atheroscleroticDeregulated Nutrient SensingAmbulatory blood pressure parameters in office normotensive obese and non-obese children: relationship with insulin resistance and atherosclerotic markers.24247272
Kidney DiseasesDeregulated Nutrient SensingThe up-regulated mTOR activity (limited to mTORC1 branch) in all glomerular and tubular epithelia from both transplant and native biopsies indicates that the activated mTOR signaling is a general phenomenon in variants of progressing renal diseases and may be used as a marker of active renal disease states.24247793
Hypertension, CTCAEDeregulated Nutrient SensingReports on the association between hypertension and insulin resistance have been inconsistent even though most studies show a definite association.24250303
Hypertension, CTCAEDeregulated Nutrient SensingIt is also not certain if the association between insulin resistance and hypertension applies to all populations.24250303
Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingTo determine the prevalence of insulin resistance in hypertensive Nigerians and to examine the association of insulin resistance with hypertension and some anthropometric indices.24250303
Antihypertensive AgentsDeregulated Nutrient SensingThe hypertensives we studied had a higher occurrence of insulin resistance compared to the normotensives.24250303
Hypertensive (finding), Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThis makes it necessary for persons with hypertensive to have regular screening for diabetes and other categories of glucose intolerance as the increased insulin increases their risk of developing type 2 diabetes mellitus.24250303
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSerum levels of cytokines and chemokines associated with cardiovascular disease in Brazilian patients treated with statins for dyslipidemia.24252254
Inflammation, Hyperemia, AtherosclerosisDeregulated Nutrient SensingPulse wave velocity of the aorta (PWV), brachial artery flow mediated dilatation (FMD), nitroglycerin mediated dilatation (NMD), microvascular endothelial function (reactive hyperemia index [RHI]), and circulating biomarkers of inflammation, insulin resistance, and atherosclerosis risk all were quantified.24252844
Dyslipidemias, Alcoholic Intoxication, Chronic, Diabetes MellitusDeregulated Nutrient SensingHigh blood pressure (22%), smoking (9*1%), alcoholism (10*8%), dyslipidemia (8*7%), and diabetes mellitus (5*4%) were the most common risk factors.24256161
Dyslipidemias, Alcoholic Intoxication, ChronicDeregulated Nutrient SensingHigh blood pressure (28*4%), dyslipidemia (20*8%), and alcoholism (17*0%) were the most common risk factors.24256161
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe High level of uric acid status in vivo appeared closely related to HOMA-IR, which could further promote the progress of pre-diabetic patients to diabetes and causing dyslipidemia.24257178
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn addition to worsening control of diabetes and dyslipidemia, severe NAFLD was confirmed.24259612
Toxic effectDeregulated Nutrient SensingA novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity.24261972
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingPatients receiving antipsychotic had higher prevalence of obesity (16.9% vs. 11.9%), smoking (22.2% vs. 11.1%), diabetes mellitus (16% vs. 11.9%), and dyslipidemia (32.8% vs. 25.8%) (p < 0.001).24265143
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingTreatment potential for dyslipidaemia management in patients with coronary heart disease across Europe: findings from the EUROASPIRE III survey.24267243
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidaemia is among the most important risk factors for coronary heart disease (CHD).24267243
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAlthough management of dyslipidaemia in CHD patients is improving, a large majority of CHD patients with dyslipidaemia is still inadequately treated and many patients on lipid-lowering therapy are not reaching the treatment goals.24267243
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingTherefore, a considerable potential still exists throughout Europe to reduce CHD mortality and morbidity rates through better treatment of dyslipidaemia.24267243
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingFurthermore, subjects with NAFLD had higher prevalence of diabetes, pathological waist-circumference, insulin-resistance and positive ATP-III criteria.24268461
Non-alcoholic Fatty Liver Disease, Hypertension, CTCAEDeregulated Nutrient SensingWhile NAFLD had only a borderline significant association with higher end-diastolic thicknesses of left-ventricle posterior wall (edPW) and right-ventricle wall, higher values of edPW and end-diastolic thickness of interventricular septum were significantly correlated with glucose levels above 100mg/dl, hypertension, MS and insulin-resistance.24268461
Arterial Stiffness, Dyslipidemias, ObesityDeregulated Nutrient SensingAn increase in the EPA/AA ratio is associated with improved arterial stiffness in obese patients with dyslipidemia.24270918
Arterial Stiffness, Inflammation, Dyslipidemias, ObesityDeregulated Nutrient SensingThese findings suggest that EPA improves the arterial stiffness in association with an increase in the EPA/AA ratio and a decrease in inflammation in obese patients with dyslipidemia.24270918
Autonomic neuropathy, Diabetes MellitusDeregulated Nutrient SensingDiabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1.24270983
Diabetes MellitusDeregulated Nutrient SensingHematopoietic Sirt1 KO mimicked the diabetic mobilization defect, whereas hematopoietic Sirt1 overexpression in diabetes rescued defective mobilization and vascular repair.24270983
Diabetes MellitusDeregulated Nutrient SensingThrough p66Shc and Sirt1, diabetes and sympathectomy elevated the expression of various adhesion molecules, including CD62L.24270983
Autonomic neuropathy, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, autonomic neuropathy in the BM impairs stem cell mobilization in diabetes with dysregulation of the life-span regulators p66Shc and Sirt1.24270983
OverweightDeregulated Nutrient SensingIn conclusion, autonomic nervous system activity was associated with cardiorespiratory fitness, insulin resistance, and SBP in overweight and obese adolescents.24272169
Dyslipidemias, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingPrevalence of dyslipidaemia in patients with renal cell carcinoma: a case-control study in China.24274674
Refractory Cytopenia of Childhood, Dyslipidemias, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingTo examine the prevalence of dyslipidaemia in patients with renal cell carcinoma (RCC) in a Chinese population.24274674
DyslipidemiasDeregulated Nutrient SensingThe lipid profiles were defined as 'normal', 'borderline high', 'high' and 'low' according to Chinese Guidelines on Adult Dyslipidaemia.24274674
Dyslipidemias, Hypertension, CTCAE, Dilated Cardiomyopathy Pathway, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingFMR patients had lower rates of hypertension and dyslipidemia, but higher rates of dilated cardiomyopathy, atrial fibrillation, and New York Heart Association functional class III/IV.24275908
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia was present in 65.7% (hypertriglyceridemia, 45.3%; increased low-density lipoprotein cholesterol, 37.5%; decreased high density lipoprotein cholesterol, 19.5%) of patients.24277052
Stomach CarcinomaDeregulated Nutrient SensingResveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent manner.24278101
Stomach CarcinomaDeregulated Nutrient SensingOur data suggest that resveratrol inhibits gastric cancer in a Sirt1-dependent manner and provide detailed evidence for the possibility of applying resveratrol in gastric cancer prevention and therapy.24278101
Dyslipidemias, EQ-5D-5L - Anxiety or DepressionDeregulated Nutrient SensingHigh blood pressure, dyslipidemia and anxiety/depression symptoms showed a mild correlation with the total score of symptoms (multiple R2 =0.18, p < 0.001).24279682
Dyslipidemias, Vestibular Diseases, EQ-5D-5L - Anxiety or DepressionDeregulated Nutrient SensingHigh blood pressure, dyslipidemia and anxiety/depression symptoms may have a mild influence on the report of symptoms of vestibular disease in both, patients and control subjects.24279682
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity, dyslipidaemia, and family history of diabetes were positively associated with both undiagnosed and diagnosed type 2 diabetes.24282548
Metabolic Syndrome XDeregulated Nutrient SensingMetabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR).24283920
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCompared to those with normal glucose tolerance, visceral fat and IR were higher and b-cell function was lower in adults with glucose intolerance and type 2 diabetes mellitus.24283920
Acute Coronary SyndromeDeregulated Nutrient Sensing[Impact of insulin resistance on prognosis in non-diabetic patients with acute coronary syndromes].24284181
Acute Coronary SyndromeDeregulated Nutrient SensingTo evaluate the impact of insulin resistance (IR) on prognosis in non-diabetic acute coronary syndrome patients.24284181
Acute Coronary SyndromeDeregulated Nutrient SensingIncreased insulin resistance is linked with poor prognosis of non-diabetic patients with acute coronary syndrome.24284181
HyperglycemiaDeregulated Nutrient SensingAnesthetic-induced transient hyperglycemia and insulin resistance do not depend on the sympathoadrenal axis.24285105
Endothelial dysfunctionDeregulated Nutrient SensingCrosstalk between inflammatory signaling pathways and insulin signaling pathways causes metabolic insulin resistance and endothelial dysfunction.24285449
DyslipidemiasDeregulated Nutrient SensingCardiac transplant patients are at risk for developing cardiac allograft vasculopathy, and dyslipidemia in this patient population has been associated with increased risk.24285762
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingType 2 DM, IFG, mixed dyslipidemia, hypertriglyceridemia, HDL-hypocholesterolemia, and LDL-hypercholesterolemia predominated in low-risk asymptomatic, while only LDL-hypercholesterolemia prevailed also in symptomatic PHPT.24287796
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingType II of dyslipidemia was typical for multifocal and coronary atherosclerosis, type IV was typical for brachiocephalic arteries.24288749
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingVariants of dyslipidemias were studied in 78 patients with atherosclerosis of various localizations.24288749
Metabolic DiseasesDeregulated Nutrient SensingLow levels of serum 25-hydroxy vitamin D [25(OH)D], as a marker of vitamin D deficiency, have been linked to a wide field of health problems, including metabolic diseases such as insulin resistance, type 1 and type 2 DM.24290086
OverweightDeregulated Nutrient SensingThe prevalence of insulin resistance in normal-weight, overweight, and obese subjects were 4.7%, 25.6%, and 47.1% respectively.24290751
Metabolic Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance (IR) is a common metabolic disorder in chronic kidney disease patients.24292690
Dyslipidemias, Diabetes Mellitus, HypothyroidismDeregulated Nutrient SensingPatients within the area covered by HoBtPCT (England) prescribed medication for dyslipidaemia, type-2 diabetes and hypothyroidism, between 2000 and 2010 inclusively.24293338
Dyslipidemias, Diabetes Mellitus, HypothyroidismDeregulated Nutrient SensingUsing data from GP prescribing systems, a computerised tool to calculate individual adherence levels for oral pharmacotherapy for the treatment of diabetes, dyslipidaemia and hypothyroidism has been developed.24293338
Hyperglycemia, Steroid-induced myopathyDeregulated Nutrient SensingHyperglycemia was determined without any clinical sign and metformin was started for steroid-induced insulin resistance.24296614
Inflammation, ObesityDeregulated Nutrient SensingObesity is associated with insulin resistance and chronic low-grade inflammation.24302564
PeriodontitisDeregulated Nutrient SensingAssociation between insulin resistance and periodontitis in Korean adults.24303984
PeriodontitisDeregulated Nutrient SensingWe investigated the association between insulin resistance and periodontitis among Korean adults.24303984
PeriodontitisDeregulated Nutrient SensingMoreover, obese post-menopausal women showed an increased association between insulin resistance and periodontitis (adjusted OR, 1.92; 95% CI,1.29-2.87).24303984
Periodontitis, ObesityDeregulated Nutrient SensingOur results suggest that insulin resistance may be associated with periodontitis, especially when combined with obesity, among post-menopausal women in Korea.24303984
DyslipidemiasDeregulated Nutrient SensingApolipoprotein A-V level may contribute to the development of obesity-associated dyslipidemia.24304484
Dyslipidemias, ObesityDeregulated Nutrient SensingInsulin may be a potent regulator of serum apoA-V level in obesity, and apoA-V level may partly contribute to the development of obesity-associated dyslipidemia.24304484
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingThus, we investigated the association between apoA-V levels and dyslipidemias in obese children with hyperinsulinemia.24304484
Thrombus, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOML test is a safe diagnostic procedure in patients with previous thrombotic events (and with the consequent associated risk factors such as diabetes mellitus or dyslipidemia) and in healthy subjects.24304733
ETV3 wt AlleleDeregulated Nutrient SensingOverall, the <= 5- or >= 9-hour sleep duration, poor-quality sleep and high-SRBD risk are related with the high prevalence of MetS, perhaps through elevated insulin-resistance resulting from adiposity.24305464
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingStudies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function.24308215
Williams SyndromeDeregulated Nutrient SensingThese data suggest that protein aggregation plays a role in the development of WS phenotypes and that the mammalian target of rapamycin complex 1 pathway is a potential therapeutic target of WS.24308646
Diabetes Mellitus, Non-Insulin-Dependent, Erectile dysfunctionDeregulated Nutrient SensingThe association between testosterone deficiency and insulin resistance in men with type 2 diabetes is well established and current endocrine society guidelines recommend the measurement of testosterone levels in all men with type 2 diabetes or erectile dysfunction.24308723
Structure of beta Cell of isletDeregulated Nutrient SensingResearch in renal transplant recipients has suggested that pancreatic b-cell dysfunction, as opposed to insulin resistance, may be the key pathologic process.24309190
Autonomic nervous system disordersDeregulated Nutrient SensingThe reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance.24309597
insensitivityDeregulated Nutrient SensingTunicamycin-induced ER stress in adipocytes can trigger autophagic response and insulin insensitivity that was partially attributed to the upregulation of IRE1-JNK pathway, whereas autophagy deficiency resulted in ER stress and impaired insulin signaling, further supporting the crucial roles of autophagy in ER stress and insulin resistance.24309597
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, our results demonstrated a reciprocal functional interaction among autophagy, ER stress, and insulin signaling in adipose tissue of type 2 diabetes and adipocytes, supporting an adaptive role of autophagy-dependent mechanism in response to ER stress-induced insulin resistance in type 2 diabetes.24309597
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is present at the muscle mitochondrial level, and is not affected by reducing circulating NEFAs in type 2 diabetes.24310562
Sleeplessness, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe associations of insomnia with hypertension and dyslipidaemia, the main modifiable cardiovascular risk factors, are less studied.24313664
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingWe especially lack understanding on the longitudinal effects of insomnia on dyslipidaemia.24313664
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular diseases are a major cause of morbidity and mortality in India, with dyslipidemia contributing significantly to the risk.24314364
Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingUsing the logistic regression model, we found age, hypertension, alcohol consumption, and abdominal obesity to be associated with increased odds of dyslipidemia.24314364
Weight decreased, Diabetes MellitusDeregulated Nutrient SensingThere is an association of the A allele with an improvement of insulin resistance secondary to weight loss after liraglutide treatment in obese patients with diabetes mellitus type 2.24322329
Breast Carcinoma, ObesityDeregulated Nutrient SensingResistin, a gene that is linked to obesity, insulin resistance, and breast cancer, was expressed more than four times higher in AA tumors.24324792
Cessation of life, Structure of beta Cell of isletDeregulated Nutrient SensingElevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic b-cell dysfunction and death in vitro.24325467
Skeletal muscle structureDeregulated Nutrient SensingAssociation between insulin resistance and low relative appendicular skeletal muscle mass: evidence from a cohort study in community-dwelling older men and women participants.24325896
Skeletal muscle structureDeregulated Nutrient SensingIt has been hypothesized that insulin resistance plays a role in the development of the loss of skeletal muscle; however, no cohort studies on insulin resistance and low relative appendicular skeletal muscle mass (ASM) have been published to date.24325896
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingObese patients were younger and more likely to have hypertension, diabetes mellitus, and dyslipidemia than normal or underweight patients.24326936
Hepatitis CDeregulated Nutrient SensingHepatitis C virus (HCV) induces insulin resistance, which improves upon viral clearance.24329983
Dyslipidemias, ObesityDeregulated Nutrient SensingThe FTO rs1421085 T>C polymorphism may modulate the magnitude of dyslipidemia in Chinese early-onset obesity.24331679
Inflammation, Periodontitis, diabeticDeregulated Nutrient SensingChronic inflammation of periodontitis aggravates glycemic control in type 2 diabetic patients through aggravation of insulin resistance.24331774
Tumor necrosisDeregulated Nutrient SensingIncreased or decreased release of various inflammatory mediators, such as high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-a, interleukin (IL)-6 and adipokines, such as adiponectin, leptin, and resistin, are presumed to be responsible for developing and progressing insulin resistance.24331774
Glucose Intolerance (disease), Liver carcinoma, HaploinsufficiencyDeregulated Nutrient SensingNCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma.24332041
Neoplasms, Dysplasia, Fatty degeneration, Glucose Intolerance (disease)Deregulated Nutrient SensingTumor development is preceded by increased interleukin-6 (IL-6) expression, early-onset glucose intolerance, and progressive steatosis and dysplasia in livers.24332041
Glucose Intolerance (disease), FAM126A geneDeregulated Nutrient SensingBlockading IL-6 overexpression averts glucose intolerance and partially deters HCC development.24332041
Glucose Intolerance (disease), Neoplasms, FAM126A geneDeregulated Nutrient SensingThese findings suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression.24332041
Inflammation, ObesityDeregulated Nutrient SensingZinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children.24335710
OverweightDeregulated Nutrient SensingInteraction analysis showed that children who were overweight and obese who also had low concentrations of vitamin A had higher CRP and lower triglycerides (p < 0.1), children with low vitamin E had significantly lower glucose and triglycerides (p < 0.1) and higher low-density lipoprotein (LDL) concentrations (p < 0.05), and children with low zinc concentrations had higher insulin resistance compared with children with adequate weight (p < 0.05).24335710
Inflammation, OverweightDeregulated Nutrient SensingFurthermore, low concentrations of zinc, vitamins A and E in children who were overweight and obese were associated with lipids, inflammation and insulin resistance.24335710
TG gene, DyslipidemiasDeregulated Nutrient SensingAssociations between seven SULF2 tagSNPs and TG levels were assessed in 210 obese T2DM subjects with dyslipidemia.24339435
Dyslipidemias, ObesityDeregulated Nutrient SensingThese findings implicate SULF2 as potential therapeutic target in the atherogenic dyslipidemia of obesity and T2DM.24339435
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingSimilar partial correlations controlling for age, gender, hypertension, smoking, dyslipidemia and ejection fraction remained significant.24340842
Dyslipidemias, ObesityDeregulated Nutrient SensingThese data indicates a small contribution of epsilon4 polymorphism in heterozygous form to the development of dyslipidemia in obesity.24340925
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient Sensing[Lipid, adipokine and ghrelin concentrations in myocardial infarction patients with insulin resistance].24340956
Dyslipidemias, Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingPredilection role diabetes mellitus and dyslipidemia in the onset of ischemic stroke.24341059
Dyslipidemias, atherosclerotic, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus as permanently elevated blood glucose, often accompanied by dyslipidemia, is among the leading causes of atherosclerotic alteration in blood vessels and is also increasing in the world.24341059
Dyslipidemias, Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingTo determine the existence and predilection of diabetes mellitus and dyslipidemia, in the development of ischemic stroke.24341059
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Cerebrovascular accidentDeregulated Nutrient SensingDiabetes mellitus and dyslipidemia, along with hypertension and smoking are the leading risk factors for the occurrence of stroke.24341059
Dyslipidemias, Coronary ArteriosclerosisDeregulated Nutrient SensingA single-nucleotide polymorphism in the proximal promoter region of the apolipoprotein M gene is associated with dyslipidaemia but not increased coronary artery diseases in Chinese populations.24341666
DyslipidemiasDeregulated Nutrient SensingThe results presented here suggest that the rs805297 SNP is not associated with an increased risk of developing CAD, although it does independently correlate with dyslipidaemia in Han Chinese individuals.24341666
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDrug-related problems in type 2 diabetes mellitus patients with dyslipidemia.24341672
DyslipidemiasDeregulated Nutrient SensingHowever, few studies have been performed on T2DM patients with dyslipidemia.24341672
DyslipidemiasDeregulated Nutrient SensingThe retrospective study involved 208 T2DM in-patients and out-patients with dyslipidemia, and was conducted at a tertiary hospital in Malaysia from January 2009 to December 2011.24341672
DyslipidemiasDeregulated Nutrient SensingThe majority of T2DM patients with dyslipidemia (91.8%) had at least one DRP.24341672
Renal Insufficiency, DENR protein, human, DyslipidemiasDeregulated Nutrient SensingMale gender, renal impairment, polypharmacy and poor lipid control were factors that were significantly associated with DRP in diabetic dyslipidemia patients.24341672
DyslipidemiasDeregulated Nutrient SensingEarly identification of DRPs and factors associated with them are essential to prevent and resolve DRPs in T2DM patients with dyslipidemia.24341672
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia prevalence was higher among Uygur (54.3%), and diabetes prevalence was higher among Hans (7.1%).24341701
Diabetes MellitusDeregulated Nutrient SensingPsychological insulin resistance in geriatric patients with diabetes mellitus.24341962
Diabetes MellitusDeregulated Nutrient SensingTo determine the extent to which geriatric patients with diabetes mellitus experience psychological insulin resistance (PIR).24341962
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigher coffee and green tea consumption has been suggested to decrease risk of type 2 diabetes, but their roles in insulin resistance (IR) and insulin secretion remain unclear.24342074
Chronic Obstructive Airway Disease, physiopathologicalDeregulated Nutrient SensingInsulin resistance may contribute to vascular dysfunction in patients with chronic obstructive pulmonary disease.24343042
Breast CarcinomaDeregulated Nutrient SensingThere was no statistically significant difference in the prognostic factors of breast cancer at the time of diagnosis between 33 patients with insulin resistance and 38 patients without insulin resistance.24344007
ThrombosisDeregulated Nutrient SensingThese findings provide new insight into the mechanisms to explain the heightened risk for thrombosis in adults with insulin resistance/diabetes.24344794
Hyperphagia, ObesityDeregulated Nutrient SensingShort sleep duration induces hormonal perturbations contributing to hyperphagia, insulin resistance, and obesity.24347344
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingArterial hypertension and dyslipidemia are modifiable cardiovascular risk factors.24348044
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe objective of this study was to determine the pattern and prevalence of dyslipidemia in newly presenting Nigerians with arterial hypertension, as well as determine some of its correlates.24348044
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe most common dyslipidemia was low HDL-C, found in both the hypertensive (44.3%) and normotensive (20.9%) patients.24348044
Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingThe prevalence of dyslipidemia in hypertensives and controls was 64% and 39%, respectively.24348044
Inflammation, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingChronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system.24348043
metabolic disturbanceDeregulated Nutrient SensingResistance to insulin actions is contributing to many metabolic disturbances.24348155
Diabetic Nephropathy, Diabetic AngiopathiesDeregulated Nutrient SensingDeregulation of miR-29 is involved in the pathogenesis of diabetic nephropathy and insulin resistance thus may be implicated in diabetic vascular complication.24349318
Dyslipidemias, atherosclerotic, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAtherosclerotic risk factors included hypertension (16%), diabetes mellitus (24%), and dyslipidemia (28%).24350411
Dyslipidemias, Diabetic AngiopathiesDeregulated Nutrient SensingThese results strengthen the rationale for studying dyslipidemia treatment to prevent diabetic microvascular disease.24352521
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe association between testosterone deficiency and insulin resistance in men with type 2 diabetes is well established.24355040
DysglycemiaDeregulated Nutrient SensingThe D2 Ala92Ala genotype is associated with reduced placental D2 activity but is not associated with dysglycemia, increased insulin resistance, or worse gestational outcomes.24355051
Hypercholesterolemia, Glucose Intolerance (disease), Chronic Obstructive Airway Disease, Diabetes MellitusDeregulated Nutrient SensingThere was no significant difference in prevalence of other comorbidities (diabetes, glucose intolerance, hypercholesterolaemia, chronic renal and chronic obstructive pulmonary disease) between studied groups (p > 0.05).24355081
DyslipidemiasDeregulated Nutrient SensingBilateral reductions in parental longevity are linked to unfavorable cardiometabolic phenotype in T2DM descendants, with worsened insulin resistance and atherogenic dyslipidemia among 1st-degree offspring.24355662
DyslipidemiasDeregulated Nutrient SensingPrevalence and severity of atherogenic dyslipidemia were raised in [SLF &/or SLM], by 53% (prevalence) and 13% (log[TG]/HDL-C) (p 0.0172 and p 0.0067).24355662
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingDespite the high percentage of drug prescription, hypertension and dyslipidemia were not fully controlled.24356735
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingAt logistic regression analyses; age, diabetes, hypertension, dyslipidemia, cardiovascular disease, obesity and lower income were found to be independent predictors for increased prevalence of MPD.24357639
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance confers risk for diabetes mellitus and associates with a reduced capacity of the arterial baroreflex to regulate blood pressure.24358272
Diabetes MellitusDeregulated Nutrient SensingOur observations may help to characterize the neural pathways by which insulin resistance, and possibly diabetes mellitus, relates to adverse cardiovascular outcomes.24358272
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIndependent risk factors for SS in patients with AF were age (OR 1.049), hypertension (OR 2.086), dyslipidemia (OR 2.073), and valvular AF (OR 3.157).24360776
Inflammation, Dyslipidemias, Abdominal aortic calcificationDeregulated Nutrient SensingOsteoprotegerin, inflammation and dyslipidemia are associated with abdominal aortic calcification in non-diabetic patients on peritoneal dialysis.24361071
Dyslipidemias, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingAge, length of stay, paroxysmal atrial fibrillation (PAF) and dyslipidemia were independent factors for the AF development.24364091
Glucose Intolerance (disease), TuberculosisDeregulated Nutrient SensingThe impact of nutrition and glucose intolerance on the development of tuberculosis in Japan.24365558
Glucose Intolerance (disease)Deregulated Nutrient SensingThe proportion of males with glucose intolerance was significantly higher in TB patients than in controls (34.2% vs. 14.4%).24365558
Glucose Intolerance (disease), Malnutrition, TuberculosisDeregulated Nutrient SensingIn Japan, the development of TB is still associated with glucose intolerance and malnutrition.24365558
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe calculated the prevalence of atherogenic dyslipidemia by sex, according to several cutoff HDL cholesterol in women, and in the whole sample, and its association with diabetes.24365578
Psychotic DisordersDeregulated Nutrient SensingPsychosis has the hallmarks of insulin resistance by at least age 25.24367528
Hypertension, CTCAE, OverweightDeregulated Nutrient SensingInterplay of overweight and insulin resistance on hypertension development.24370898
Metabolic Diseases, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity and hypertension are associated, possibly through causal pathways involving insulin resistance and metabolic derangements.24370898
Hypertension, CTCAE, OverweightDeregulated Nutrient SensingWe aimed to investigate in a whites sample if overweight or obese persons without insulin resistance are at risk of developing hypertension or blood pressure progression.24370898
Hypertension, CTCAE, OverweightDeregulated Nutrient SensingAccording to this study, being overweight or obese without insulin resistance increases the risk of hypertension and blood pressure progression.24370898
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function.24372992
vascular inflammations, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAspirin exhibited no significant dose-dependent effect on markers of vascular inflammation, oxidative stress, insulin resistance and endothelial function (photoplethysmography) when used in type 2 diabetes over a 2-week period.24372992
Dyslipidemias, Overweight, ObesityDeregulated Nutrient Sensing[Prevalence and risk factors for dyslipidemia in diabetics with overweight or obesity].24373394
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingTo explore the prevalence and risk factors for dyslipidemia in diabetics with overweight or obesity.24373394
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingDyslipidemia was detected in 3160/3593 (87.9%) diabetics with overweight or obesity.24373394
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe prevalence of dyslipidemia is quite high in diabetics with overweight or obesity.24373394
Cardiac complication, Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe controls of blood pressure, serum uric acid level, blood glucose and body weight may reduce the prevalence of dyslipidemia, prevent and delay the development of cardiovascular complications and reduce the mortality of diabetics with overweight or obesity.24373394
Metabolic DiseasesDeregulated Nutrient SensingTrunk and android fat deposition aggravates insulin resistance, metabolic disorders.24373397
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAfter multiple stepwise regression analysis, the main influencing factors of lnHOMA-IR and lnHOMA-b were T/B and Grespectively.Logistic regression showed that A (OR = 3.01, 95%CI 1.86-8.17) was a risk factor for diabetes and A/G (OR = 2.71, 95%CI 1.75-6.56) a risk factor for dyslipidemia.24373397
ObesityDeregulated Nutrient SensingObesity, insulin resistance, lipid peroxidation and oxidative stress have been identified amongst the possible hits leading to the onset and progression of this disease.24373555
DyslipidemiasDeregulated Nutrient SensingSecondary outcome was dyslipidemia [low-density lipoprotein (LDL)>= 100].24374412
Colorectal CarcinomaDeregulated Nutrient SensingInsulin resistance (IR) is an established risk factor for colorectal cancer (CRC).24377587
United States Minor Outlying Islands, Glucose Intolerance (disease)Deregulated Nutrient SensingWe evaluated UMI as a screening tool for glucose intolerance.24377833
Glucose Intolerance (disease)Deregulated Nutrient SensingD-UMI, 2h-UMI and HbA1c levels significantly increased as glucose intolerance worsened.24377833
Glucose Intolerance (disease)Deregulated Nutrient Sensing2h-UMI is useful as a non-invasive screening of glucose intolerance.24377833
OverweightDeregulated Nutrient SensingTreatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance.24378016
Dyslipidemias, OverweightDeregulated Nutrient SensingSixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2g/day extended-release nicotinic acid (ERN), 4g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks.24378016
Dyslipidemias, EpidemicDeregulated Nutrient Sensing[Epidemic features of dyslipidemia among Uygur, Kazakh, and Han adults in Xinjiang, China in 2010].24378138
TG gene, Dyslipidemias, diabeticDeregulated Nutrient SensingHowever, diabetic patients with severe atherogenic dyslipidemia (LDL-C >=130, TG >=204, and HDL-C <=34 mg/dl) obtained more benefits in terms of HDL-C change after statin therapy.24380094
Dyslipidemias, diabeticDeregulated Nutrient SensingDiabetic patients, except those with severe atherogenic dyslipidemia, are prone to a decrease in serum HDL-C level after statin treatment, particularly after atorvastatin treatment.24380094
Psoriasis, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Systemic disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingRecent studies suggest that psoriasis is a systemic disorder associated with cardiovascular disease (CVD) risk factors, such as obesity, hypertension and dyslipidemia.24385235
TG gene, CD55 geneDeregulated Nutrient SensingIn a large cardiovascular disease-free cohort, NT-proBNP within the lower (physiological) range was inversely associated with TC, LDL-C, TG and insulin resistance with different inflection points, but at higher (pathological) levels these associations were blunted.24388001
Pancreatic NeoplasmDeregulated Nutrient SensingFinally, RalGAP suppression caused mTORC1-dependent pancreatic tumor cell invasion.24389102
Congenital Heart DefectsDeregulated Nutrient SensingPredictors for a metabolically abnormal phenotype (>=3 cardiometabolic abnormalities or insulin resistance) were determined.24389519
InflammationDeregulated Nutrient SensingSerum lipocalin-2, which correlates with inflammation and insulin resistance, may have a direct pathogenic link to disease progression.24390241
Dyslipidemias, Lupus Erythematosus, Systemic, AtherosclerosisDeregulated Nutrient SensingIn the SLE group, FABP4 was associated with IR, atherogenic dyslipidaemia, as measured by NMR, and the presence of subclinical atherosclerosis.24390652
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAssociation between obesity and therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia.24393753
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingObesity is associated with cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes mellitus, as well as cardiovascular diseases.24393753
Failure (biologic function), Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingObesity appears to be an independent risk factor for the failure to attain BP and dual BP and low-density lipoprotein cholesterol goals in patients with concomitant hypertension and dyslipidemia.24393753
Dyslipidemias, Smoking, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingPresence of Diabetes, Hypertension, Smoking, Dyslipidemia, Sedentary life style, and Obesity was looked for in these patients.24397066
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingSedentary life style (53.84%) was the most common risk factor present in these patients followed by hypertension and dyslipidemia (47.11% each), smoking (43.27%), diabetes (35.57%), and obesity (9.61%).24397066
Dyslipidemias, Erectile dysfunctionDeregulated Nutrient SensingHigher HbAlc levels and atherogenic dyslipidaemia were associated with erectile dysfunction.24397090
MS geneDeregulated Nutrient SensingSIRT1 is decreased during relapses in patients with multiple sclerosis.24397908
MS geneDeregulated Nutrient SensingWe investigated the expression of SIRT1 in multiple sclerosis (MS) brains and in peripheral blood mononuclear cells (PBMCs) obtained from patients with relapsing-remitting multiple sclerosis.24397908
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingSex, diabetes, dyslipidaemia, hypertension or obesity did not significantly influence Tang in patients, although detected in smokers.24399233
Chronic Kidney DiseasesDeregulated Nutrient SensingWe show that irisin serum concentrations decrease with increasing CKD stage and are independently and positively predicted by renal function and insulin resistance.24399249
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHowever, many patients on statin treatment have persistent dyslipidemia and remain at a high risk of cardiovascular disease.24400085
Inflammation, Muscle (organ)Deregulated Nutrient SensingAlthough the causes of muscle loss are poorly understood, dietary fat has been postulated to have a role in determining protein turnover through an influence on both inflammation and insulin resistance.24401817
Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingSeveral conditions such as hypertension, diabetes, and obesity can impair shear stress, but the role of insulin resistance has never been investigated.24402299
Inflammation, Low muscle mass, Endothelial dysfunctionDeregulated Nutrient SensingIncreasing physical activity, consuming a diet with a high proportion of energy from carbohydrates, and taking steps to prevent insulin resistance and reduce inflammation and endothelial dysfunction may help to reduce the risk of low muscle mass in older men.24402385
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMany studies have shown that single nucleotide polymorphisms (SNPs) in the Adiponectin gene are associated with low plasma Adiponectin levels, insulin resistance and an increased risk of type 2 diabetes mellitus.24404592
Diabetes MellitusDeregulated Nutrient SensingRole of adiponectin in mediating the association of osteocalcin with insulin resistance and type 2 diabetes: a cross sectional study in pre- and post-menopausal women.24405382
Diabetes MellitusDeregulated Nutrient SensingThe protective action of osteocalcin against the development of insulin resistance and type 2 diabetes in women may be partially mediated through up-regulation of adiponectin secretion.24405382
Hyperglycemia, Diabetes MellitusDeregulated Nutrient SensingGlycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes.24405752
Chronic heart failureDeregulated Nutrient SensingSpironolactone, not furosemide, improved insulin resistance in patients with chronic heart failure.24405838
Chronic heart failure, Congestive heart failureDeregulated Nutrient SensingInsulin resistance plays an important role in the pathophysiology in chronic heart failure (CHF).24405838
Congestive heart failureDeregulated Nutrient SensingDiuretics generally have harmful effects on glucose metabolism, however, the effect of mineral corticoid receptor blockers on insulin resistance in CHF is unclear.24405838
Congestive heart failureDeregulated Nutrient SensingSpironolactone, not furosemide, improved insulin resistance in CHF patients probably by the inhibition of inflammatory cytokines and MMPs.24405838
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingSIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival.24410795
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingIn the literature there is no evidence for SIRT1 signalling in vitiligo and its possible involvement in disease progression.24410795
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingHere, biopsies were taken from the perilesional skin of 16 patients suffering from non-segmental vitiligo and SIRT1 signalling was investigated in these cells.24410795
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingFor the first time, a new SIRT1/Akt, also known as Protein Kinase B (PKB)/mitogen-activated protein kinase (MAPK) signalling has been revealed in vitiligo.24410795
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingSIRT1 regulates MAPK pathway via Akt-apoptosis signal-regulating kinase-1 and down-regulates pro-apoptotic molecules, leading to decreased oxidative stress and apoptotic cell death in perilesional vitiligo keratinocytes.24410795
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingWe therefore propose SIRT1 activation as a novel way of protecting perilesional vitiligo keratinocytes from damage.24410795
Alzheimers Disease", Impaired cognition, Data types - Address, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and type 2 diabetes are associated with cognitive decline and increased risk for Alzheimer's disease (AD).24411018
Heart Diseases, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingMale stroke patients were more likely to have a history of smoking, heart disease and dyslipidemia, while female patients were less likely to achieve daily living independence.24411132
Ischemia, DyslipidemiasDeregulated Nutrient SensingThe aim of the study was to define the role of CIDEA gene in patients with dyslipidemia and symptomatic limb ischemia.24413203
Liver carcinomaDeregulated Nutrient SensingDepletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells.24416313
Liver carcinomaDeregulated Nutrient SensingWe have recently found that SIRT1 expression is highly elevated in hepatocellular carcinoma, and the depletion of SIRT1 leads to substantial reduction in TERT mRNA and protein expression.24416313
Dyslipidemias, ObesityDeregulated Nutrient SensingIt can be concluded that dyslipidemia and obesity were prevalent amongst this group of women.24418877
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRecent research has indicated a relationship between skeletal muscle mass and insulin resistance in patients with type 2 diabetes mellitus (T2DM).24420336
Diabetic NephropathyDeregulated Nutrient SensingIn this study, we investigated whether AMPK-mediated Cx43 expression and premature senescence in diabetic nephropathy are associated with mTOR activation.24423443
Diabetic NephropathyDeregulated Nutrient SensingFrom in vivo and in vitro studies, we found decreased expression of Cx43 and p-AMPK but increased expression of p21 both in the glomeruli of diabetic nephropathy and in primary GMCs cultured in high glucose.24423443
therapeutic hemodilutionDeregulated Nutrient SensingCEA may be affected in obese individuals by several factors, including but not limiting to hemodilution, inflammatory conditions, and insulin resistance.24425143
Liver carcinoma, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOpposite association between diabetes, dyslipidemia, and hepatocellular carcinoma mortality in the middle-aged and elderly.24425422
Dyslipidemias, FAM126A geneDeregulated Nutrient SensingMore research is needed to elucidate why having baseline dyslipidemia relates to lower future HCC mortality.24425422
Overweight, ObesityDeregulated Nutrient SensingThis study of a cohort of overweight and obese subjects has shown that insulin resistance (dependent variable) is positively associated with C3 serum levels, independently of age, gender, anthropometric parameters and physical activity, suggesting that higher C3 serum levels may directly increase insulin resistance in obesity.24428680
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingLipid, adipokine and ghrelin levels in myocardial infarction patients with insulin resistance.24433403
Electrocardiogram: myocardial infarction (finding), Coronary ArteriosclerosisDeregulated Nutrient SensingInsulin resistance (IR) is a risk factor for ischaemic heart disease and myocardial infarction (MI).24433403
Hypoglycemia, Dyslipidemias, HyperinsulinismDeregulated Nutrient SensingDyslipidaemia, along with insulinaemia and glycaemia, is one of the most significant IR risk factors in the acute and early recovery phases of MI.24433403
Glucose Intolerance (disease), UlcerDeregulated Nutrient SensingWe enrolled 25 obese subjects without glucose intolerance (group A; BMI greater than 30 kg/m2), 20 obese adults intolerant to glucose (group B) and two subgroups, groups C and D, with T2DM and with leg ulcers.24434128
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOatmeal diet days may improve insulin resistance in patients with type 2 diabetes mellitus.24434762
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension often coexists with dyslipidemia, accentuating cardiovascular risk.24436326
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance participates in the pathogenesis of multiple metabolic and cardiovascular diseases.24436478
Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Diabetes MellitusDeregulated Nutrient SensingThis ratio increases when adjusted for sex, hypertension, dyslipidaemia, smoking, diabetes and atrial fibrillation (OR, 2.6; 95% CI, 1.5-4.7).24438335
Injury of kidneyDeregulated Nutrient SensingKidney injury molecule (KIM)-1 is associated with insulin resistance: results from two community-based studies of elderly individuals.24438875
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance has been shown to be closely associated with glomerular filtration rate and urinary albumin/creatinine ratio, even prior to the development of diabetes.24438875
Renal tubule structureDeregulated Nutrient SensingThe role of insulin resistance in the development of kidney tubular damage is not previously reported.24438875
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients from high-income countries were older, and were more likely to have diagnosed hypertension and dyslipidemia.24440324
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingIndividuals with metabolic risk factors, particularly, insulin resistance, diabetes, and overweight/obesity, have a high prevalence of NAFLD estimated up to 70%, yet little is known about the understanding and perceptions of NAFLD in these high-risk patients.24440943
Primary malignant neoplasmDeregulated Nutrient SensingThe protein deacetylase SIRT1 regulates various pathways in metabolism, aging and cancer.24441046
Malignant neoplasm of skinDeregulated Nutrient SensingHowever, the role of SIRT1 in skin cancer remains unclear.24441046
Ultraviolet B radiation, Malignant neoplasm of skinDeregulated Nutrient SensingHere, using mice with targeted deletions of SIRT1 in their epidermis in both resistant B6 and sensitive SKH1 hairless backgrounds, we show that the role of SIRT1 in skin cancer development induced by ultraviolet B (UVB) radiation is dependent on its gene dose.24441046
Brain Injury, Chronic, NeoplasmsDeregulated Nutrient SensingKeratinocyte-specific heterozygous deletion of SIRT1 promotes UVB-induced skin tumorigenesis, whereas homozygous deletion of SIRT1 suppresses skin tumor development but sensitizes the B6 mice to chronic solar injury.24441046
Squamous cell carcinoma of skinDeregulated Nutrient SensingAs compared with normal human skin, downregulation of SIRT1 is in parallel with downregulation of XPC in human cutaneous squamous cell carcinoma at both the protein and mRNA levels.24441046
Primary malignant neoplasmDeregulated Nutrient SensingOur results reveal the gene dosage-dependent in vivo functions of SIRT1 in skin tumorigenesis and may shed light on the role of SIRT1 in epithelial cancer induced by DNA damage.24441046
Steatohepatitis, Dyslipidemias, Dystonia, Dopa-Responsive, due to Sepiapterin Reductase DeficiencyDeregulated Nutrient SensingOffspring where SRD was fed at any period of life showed: (1) increased adipose tissue weight without changes in the final body weight; (2) dyslipidemia as a result of increased very low density lipoprotein triglyceride secretion rate and decreased triglyceride clearance; (3) hepatic steatosis associated with increased activity of key enzymes involved in liver de novo lipogenesis and significant decrease of the activity of mitochondrial fatty acid oxidation enzyme.24445301
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.24446723
Diabetes MellitusDeregulated Nutrient SensingProliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.24447396
Diabetes MellitusDeregulated Nutrient SensingThe peroxisome proliferator-activated receptor gamma (PPARG), Pro12Ala and the insulin receptor substrate (IRS1), Gly972Arg confer opposite effects on insulin resistance and type 2 diabetes mellitus (T2DM).24447396
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingA total of 68% of PCOS adolescents had insulin resistance.24447981
Dyslipidemias, Diabetes Mellitus, Abnormal renal function, Cerebrovascular Disorders, Hypertension, CTCAEDeregulated Nutrient SensingIn the univariate analysis, the major risk factors for kidney dysfunction in the patients with the cardio-cerebrovascular disease were age, gender, hypertension, diabetes mellitus, dyslipidemia and serum uric acid.24448380
diabeticDeregulated Nutrient SensingIn addition to comparing the neuroimaging profiles of both groups, we correlated neuroimaging findings with HbA1c levels, duration of T2DM, and insulin resistance measurement (HOMA-IR) in the diabetic patients group.24448784
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSecond-line treatments for dyslipidemia in patients at risk of cardiovascular disease.24452015
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe cardiovascular risk factors of ACS were hypertension(HT), diabetes mellitus(DM), smoking, dyslipidemia and obesity(BMI >= 23 kg/m(2)).24452116
Dyslipidemias, HaitiDeregulated Nutrient SensingIn the elderly group, the prevalence of HT and DM were 84.6% and 29.0% higher than that in the non elderly group; the prevalence of smoking and dyslipidemia were 22.0% and 56.9% lower than that in the non-elderly group.24452116
Hypertensive disease, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, OverweightDeregulated Nutrient SensingThe prevalence of HTN and DM was higher, smoking and dyslipidemia were lower, being overweight and having a prior myocardial infarction was similar to that of the non-elderly group.24452116
Pancreatic carcinomaDeregulated Nutrient SensingAlthough significant, the degree of correlation was weakened in the subjects without pancreatic cancer because some had lower insulin secretory reserve compensated by less insulin resistance, resulting in inappropriately elevated G/I ratios relative to A1C.24452875
Dyslipidemias, Hyperglycemia, Hypertension, CTCAE, Vascular DiseasesDeregulated Nutrient SensingAll patients received multifactorial intervention, with pharmacologic therapy targeting hyperglycemia, hypertension, dyslipidemia, along with secondary prevention of vascular disease with aspirin when necessary according to the ADA recommendation.24452874
Heart failure, AtherosclerosisDeregulated Nutrient SensingInsulin resistance and incident heart failure the ARIC study (Atherosclerosis Risk in Communities).24455475
Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus increases the risk for HF, but the association between insulin resistance and HF in individuals without diabetes is unclear.24455475
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe Japan Atherosclerosis Society's 2007 Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases (JAS2007GL) advocate reducing LDL cholesterol (LDL-C) to target levels in patients with dyslipidemia, but achievement rates are frequently unsatisfactory even in the presence of lipid-lowering therapy.24456217
Inflammation, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India.24456991
Inflammation, Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingVitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFa and IL6).24456991
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidemia is a significant contributor to the elevated CVD risk observed in type 2 diabetes mellitus.24461346
Inflammation, Diabetes MellitusDeregulated Nutrient SensingEffect of a mixed meal on plasma lipids, insulin resistance and systemic inflammation in non-obese Indian adults with normal glucose tolerance and treatment naive type-2 diabetes.24461623
DyslipidemiasDeregulated Nutrient SensingHigh post meal glucose levels have been linked to postprandial dyslipidemia and generation of proinflammatory cytokines.24461623
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingGroup medical clinics may improve diabetes and hypertension control, but data about dyslipidemia are limited.24462012
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn 2011, the majority belonged to stages 3A (39.6%) and 3B (37.6%), had hypertension (98.2%), dyslipidemia (97.2%) and diabetes mellitus (68.7%).24463824
Data types - AddressDeregulated Nutrient SensingOur study revealed that (1) the neuronal subcellular redistribution of SIRT1 parallels the decrease in its expression, suggesting stepwise loss of neuroprotection dependent on the neuronal population; (2) in contrast to SIRT1 and 3, expression of SIRT5 increases during the progression of AD; (3) which might be related to its appearance in activated microglial cells.24464653
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn simple regression analysis, free testosterone levels were associated with increased age (b = -0.04; P = .02), diet (b = -0.49; P = .05), diabetes (b = -0.9; P = .003), and hypertension (b = -0.55; P = .03) but not with race/ethnicity, smoking, exercise, obesity, or dyslipidemia.24468578
Increased insulin level, Diabetes MellitusDeregulated Nutrient SensingThe proband's mother had hyperinsulinemia and diabetes mellitus but did not show any common clinical features of type A insulin resistance.24468607
Increased insulin level, Glucose Intolerance (disease)Deregulated Nutrient SensingThe proband's brother also had hyperinsulinemia but manifested neither glucose intolerance nor common clinical features of type A insulin resistance.24468607
Refractory anemias, Diabetes MellitusDeregulated Nutrient SensingWe examined the effect of HCQ on insulin resistance in subjects without diabetes mellitus with stable RA.24470436
Refractory anemias, Diabetes MellitusDeregulated Nutrient SensingHCQ use for 8 weeks in patients without diabetes mellitus with stable RA produced no significant change in insulin resistance.24470436
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHowever, risk factors such as age, BMI, hypertension, dyslipidemia, diabetes mellitus and smoking have a strong impact on stroke occurrence and outweigh the protective role of the e3/e3 genotype.24471738
Dyslipidemias, Osage languageDeregulated Nutrient SensingDespite similar body mass index (BMI) and waist circumference, men had larger VFA, more severe OSA, and more severe dyslipidemia than women.24471804
Inflammation, physiopathologicalDeregulated Nutrient SensingAdipose dysfunction resulting from chronic inflammation and impaired adipogenesis has increasingly been recognized as a major contributor to obesity-mediated insulin resistance, but the molecular mechanisms that maintain healthy adipocytes and limit adipose inflammation remain unclear.24473437
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThese data suggest that the SK1-S1P axis could be an attractive target for the development of treatments to ameliorate adipose inflammation and insulin resistance associated with obesity and type 2 diabetes.24473437
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance (IR) in skeletal muscle is a prerequisite for type 2 diabetes and is often associated with obesity.24473441
Dyslipidemias, Smoking, Coronary heart diseaseDeregulated Nutrient SensingSmoking, dyslipidemia, family history, and lipoprotein(a) and lymphotoxin-alfa mutations in men were independent variables associated with coronary disease.24473507
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingSIRT1/macroH2A1.1-dependent epigenetic regulation of lipid metabolism may be relevant to NAFLD development.24473773
Acquired Immunodeficiency Syndrome, DyslipidemiasDeregulated Nutrient SensingThe effects of a diet formulation with oats, soybeans, and flax on lipid profiles and uricemia in patients with AIDS and dyslipidemia.24474009
Lipodystrophy, Hyperglycemia, Metabolic Diseases, DyslipidemiasDeregulated Nutrient SensingAlthough the initiation of highly active antiretroviral therapy (HAART) is accompanied by an attenuation of viral load, metabolic disorders characterized by hyperglycemia, dyslipidemia, and lipodystrophy are often observed in patients under this treatment.24474009
Dyslipidemias, Psoriasis, ObesityDeregulated Nutrient SensingObesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus.24474099
Dyslipidemias, Psoriasis, ObesityDeregulated Nutrient SensingTo evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus.24474099
Dyslipidemias, Psoriasis, ObesityDeregulated Nutrient SensingWe performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis.24474099
DyslipidemiasDeregulated Nutrient SensingRegarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile.24474099
Metabolic Diseases, Dyslipidemias, Psoriasis, ObesityDeregulated Nutrient SensingThe occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory.24474099
Cancer-related fatigue, DyslipidemiasDeregulated Nutrient SensingHigh cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations.24474445
Chronic Kidney DiseasesDeregulated Nutrient SensingRegardless of CKD strata, all ISIs allowed satisfactory clinical discrimination between the presence and absence of insulin resistance (glucose disposal rate under 4 mg/kg/min).24476695
Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, ObesityDeregulated Nutrient SensingOur results lead to the hypothesis that changes in biomarker levels of insulin resistance, inflammation and CVD risk before puberty might induce metabolic consequences of obesity in obese children before reaching adulthood.24476930
Chronic diseaseDeregulated Nutrient SensingInsulin resistance is a significant cross-point for the manifestation of several chronic diseases in children and adults.24477051
Complication Aspects, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNew-onset diabetes after transplantation (NODAT) and dyslipidemia are important metabolic complications after liver transplantation (LT) that can adversely affect both allograft and patient survival.24477986
Dyslipidemias, Cardiovascular Diseases, Kidney Failure, Diabetes MellitusDeregulated Nutrient SensingSubjects were older and had higher rates of family history of cardiovascular disease in Australia, while Asian subjects had higher rates of diabetes, dyslipidemia and renal failure.24480180
Demographics Domain, Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingOver half patients (87, 55%) had arterial hypertension (AH); 51 (32%) had dyslipidaemia (DLP), 38 (29%) hypertriglyceridemia and 36 (23%) diabetes mellitus (DM).24480317
Pre-Gestational Diabetes, Pre-EclampsiaDeregulated Nutrient SensingAssessment of pregestational insulin resistance as a risk factor of preeclampsia.24480896
Pre-Gestational Diabetes, Pre-EclampsiaDeregulated Nutrient SensingTo assess the impact that pregestational insulin resistance (PIR) has as a risk factor for preeclampsia (PE).24480896
Pancreatic carcinomaDeregulated Nutrient SensingOur previous research showed that sirtuin 1 (SIRT1) was overexpressed in pancreatic cancer patients and deregulation of SIRT1 with RNAi could enhance chemosensitivity.24484175
Palmar-plantar erythrodysesthesia syndrome, Pancreatic carcinomaDeregulated Nutrient SensingThus, we hypothesized that SIRT1 might facilitate chemoresistance in pancreatic cancer cells through regulating the adaptive response to chemotherapy-induced stress.24484175
Pancreatic carcinomaDeregulated Nutrient SensingTo further confirm the role of SIRT1 in clinical chemotherapy, SIRT1 was detected in eight pancreatic cancer tissues acquired by endoscopy ultrasonography guided fine needle aspiration biopsy before and after chemotherapy.24484175
Palmar-plantar erythrodysesthesia syndromeDeregulated Nutrient SensingThus, our results indicated a special role for SIRT1 in the regulation of adaptive response to chemotherapy-induced stress, which is involved in chemoresistance.24484175
Pancreatic carcinomaDeregulated Nutrient SensingMoreover, it indicates that blocking SIRT1 activity with targeting drugs might be a novel strategy to reverse the chemoresistance of pancreatic cancer.24484175
Palmar-plantar erythrodysesthesia syndrome, Pancreatic carcinomaDeregulated Nutrient SensingSirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress.24484175
Hypertension, CTCAE, Overweight, DyslipidemiasDeregulated Nutrient SensingPatients with HFpEF (n = 499) were older, overweight, predominantly women, and had underlying hypertension and dyslipidemia.24484862
Fatty LiverDeregulated Nutrient SensingAmong polymorphisms, C677T, a thermolabile form, but not A1298C, thermostable, was associated with fatty liver and insulin resistance.24488901
Diabetes Mellitus, Ketosis-Prone, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe KPD patients were more likely to have a strong family history of diabetes and a better beta-cell function reserve, and be accompanied with dyslipidemia (52.7%), hypertension (23.3%), fatty liver (10.1%) and hyperuricemia/gout (8.24490509
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingModifiable cardiovascular risk factors were dominated by dyslipidemia, diabetes and obesity/overweight.24492012
Arterial Stiffness, Diabetes MellitusDeregulated Nutrient SensingThe elevated plasma glucose level and/or insulin resistance in diabetes or impaired glucose tolerance play important roles in the pathogenesis of arterial stiffness.24492686
Dyslipidemias, Cerebral HemorrhageDeregulated Nutrient SensingDyslipidemia as a risk factor for primary intracerebral hemorrhage.24496338
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingThe insulin resistance and vitamin D deficiency significantly predicted the obesity risk in PCOS women.24496360
Diabetes MellitusDeregulated Nutrient SensingTNF-a polymorphisms were shown to be associated with insulin resistance and diabetes development and complications.24497209
Dyslipidemias, ObesityDeregulated Nutrient SensingModerate changes in obesity measures tracked with a significant deterioration in measures of pro-atherogenic dyslipidaemia at both personal and population level.24497983
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Renal function, Diabetes MellitusDeregulated Nutrient SensingAge, diabetes, dyslipidaemia and history of myocardial infarction were identified as significant predictors for renal function deterioration based on results from multivariate Cox regression model.24499317
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women.24502610
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHousehold income and LDL-C goal attainment in patients with diabetes and dyslipidemia in a Canadian dataset.24502811
Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity and insulin resistance are risk factors for cardiovascular diseases.24502884
SLC25A20 gene, Dyslipidemias, Comorbidity, Cardiovascular DiseasesDeregulated Nutrient SensingIn univariate Cox regression analyses, age, cardiovascular disease, dyslipidemia, increased CAC score, increased comorbidity score and decreased hip BMD were associated with mortality.24503711
Acute leukemiaDeregulated Nutrient SensingWe first analyzed the expression of miR-34a, CDK4, MYB and SIRT1 in peripheral blood samples from acute leukemia (AL) patients and healthy controls, and conducted a correlation analysis.24504520
Acute leukemiaDeregulated Nutrient SensingmiRNA-34a downregulates the expression of the CDK4, MYB and SIRT1 genes in vitro; it may thus represent a novel therapeutic target for acute leukemia.24504520
ADIPOQ protein, humanDeregulated Nutrient Sensing[Association of resistin gene 3'UTR+62G>A polymorphism with insulin resistance, adiposity and the adiponectin-resistin index in Mexican population].24506362
Hyperparathyroidism, Hyperparathyroidism, Primary, Glucose Intolerance (disease)Deregulated Nutrient SensingPrimary hyperparathyroidism and secondary hyperparathyroidism are both associated with abnormalities in glucose metabolism, such as insufficient insulin release and glucose intolerance.24507041
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient Sensing[Association between dyslipidemia and different subtypes of hypertension among Zhejiang population in 2010].24507231
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingTo explore the association between dyslipidemia and different subtypes of hypertension among Zhejiang population.24507231
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia is an important factor of different subtypes of hypertension among Zhejiang population, especially triglycerides.24507231
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia screening should be strengthened to reduce the risk of cardiovascular diseases.24507231
Dyslipidemias, Primary Biliary Cholangitis, DeteriorationDeregulated Nutrient SensingBecause the majority of PBC patients exhibit a slow progression of their disease, and since the administration of UDCA plus fibrate may further delay the liver deterioration, cardiovascular risk factors, such as dyslipidemia may thus have a bigger impact on the long-term survival of PBC patients.24511666
ObesityDeregulated Nutrient SensingDisruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance.24512489
ObesityDeregulated Nutrient SensingOur objective was to define the function of GIP in human adipose tissue in relation to obesity and insulin resistance.24512489
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Carotid Intima-Media ThicknessDeregulated Nutrient SensingNonalcoholic Fatty liver disease is associated with increased carotid intima-media thickness only in type 2 diabetic subjects with insulin resistance.24512497
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, atheroscleroticDeregulated Nutrient SensingThe objective of the study was to investigate the participation of insulin resistance in the association of NAFLD and the carotid atherosclerotic burden in a large cohort of patients with type 2 diabetes.24512497
Non-alcoholic Fatty Liver Disease, AtherosclerosisDeregulated Nutrient SensingThere were significant differences in C-IMT and the frequency of carotid atherosclerosis between groups classified by insulin resistance within the same NAFLD strata.24512497
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingC-IMT was highest in subjects with both NAFLD and insulin resistance [0.844 +- 0.004 (mean +- SE) mm vs 0.786 +- 0.008, 0.821 +- 0.007, and 0.807 +- 0.006 mm, P for trend <.001, respectively, in insulin sensitive subjects without NAFLD, insulin resistant subjects without NAFLD, and insulin sensitive subjects with NAFLD].24512497
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHowever, C-IMT in subjects having only NAFLD or insulin resistance was not higher than that in those with neither NAFLD nor insulin resistance.24512497
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, atheroscleroticDeregulated Nutrient SensingNAFLD is very common in subjects with type 2 diabetes, but NAFLD not accompanied by insulin resistance is not associated with a carotid atherosclerotic burden.24512497
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHowever, having both NAFLD and insulin resistance seemed to be an independent predictor of increased C-IMT.24512497
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Diabetes MellitusDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is linked to increased risk of insulin resistance and diabetes mellitus in patients' later life.24515540
Inflammation, ImpairedDeregulated Nutrient SensingTNFa is suspected to play a role in inflammation and insulin resistance leading to higher risk of metabolic impairment.24517151
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe control rate was significantly lower among patients with longer course of diabetes and dyslipidemia.24517934
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingIn approximately 50-70% of all women with PCOS (Polycystic Ovarian Syndrome) may be found lower or higher degree insulin resistance, while insensitivity to insulin cells very likely contributes hyperandrogenaemia which is responsible for the symptoms and signs of PCOS.24520755
Prediabetes syndromeDeregulated Nutrient SensingThe emergence of prediabetes is significantly correlated with insulin resistance as confirms the impact of the insulin resistance degree to the emergence of prediabetes.24520755
DyslipidemiasDeregulated Nutrient SensingDyslipidemia is a risk factor for premature cardiovascular morbidity and mortality in renal transplant recipients (RTRs).24521776
Ventricular DysfunctionDeregulated Nutrient SensingEarly subclinical ventricular dysfunction in patients with insulin resistance.24522082
Ventricular Dysfunction, LeftDeregulated Nutrient SensingInsulin resistance is frequently associated with subclinical left-ventricular dysfunction.24522082
ShockDeregulated Nutrient SensingHeat shock protein inducers share metabolic pathways associated with exercise with activation of AMPK, PGC1-a, and sirtuins.24523032
Presenile dementia, Impaired cognitionDeregulated Nutrient SensingIn addition to insulin resistance, elevated inflammatory cytokines and oxidative stress were associated with cognitive impairment in this type of dementia.24523311
Hepatitis CDeregulated Nutrient SensingInterleukin 28B genotype and insulin resistance in chronic hepatitis C patients.24523350
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn a multiple logistic regression model, male sex, diabetes, and prior CAD predicted adverse events, whereas CK-MB along with race, hypertension, smoking, dyslipidemia, family history, and obesity did not.24526146
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary Artery Disease, Cerebrovascular accidentDeregulated Nutrient SensingNo significant differences in the rates of dyslipidaemia, previous myocardial infarction, previous stroke, and coronary artery disease were seen between the groups.24526553
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Fatty Liver DiseaseDeregulated Nutrient SensingNon alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance (IR) and increased type 2 diabetes (T2D).24528352
Diabetes MellitusDeregulated Nutrient SensingOur study demonstrated that ALT, but not AST, was significantly correlated with of insulin resistance and inflammatory markers, all of them recognized as risk parameters of pre diabetes stage.24528352
AtherosclerosisDeregulated Nutrient SensingInsulin resistance (IR) plays a role in the development and progression of atherosclerosis.24529152
DyslipidemiasDeregulated Nutrient SensingDyslipidemia, especially an increased LDL-cholesterol, has been shown to be one of the most important risk factors in the genesis of coronary involvement.24529919
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingIncreased insulin concentration is a surrogate for insulin resistance and early assessment of fasting insulin may help in identifying those who are potentially at high risk of type 2 diabetes, hypertension, and cardiovascular disease.24530467
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a risk factor for not only cardiovascular diseases (CVD), but also chronic kidney disease (CKD).24531086
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingHowever, very few studies have examined its efficacy and safety for patients with dyslipidemia complicated with CKD.24531086
Cardiovascular Diseases, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Cerebrovascular accident, Coronary Artery Disease, Obesity, Cessation of life, Hypertension, CTCAEDeregulated Nutrient SensingCardiovascular disease (CVD) risk factors, such as arterial hypertension, obesity, dyslipidemia or diabetes mellitus, as well as CVDs, including myocardial infarction, coronary artery disease or stroke, are the most prevalent diseases and account for the major causes of death worldwide.24532105
Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingThe study sample was 1,016 participants in the insulin resistance atherosclerosis study, who had no previous diagnosis of diabetes.24532116
Heat-Shock ResponseDeregulated Nutrient SensingMuscle heat shock protein 70 predicts insulin resistance with aging.24532784
Rheumatoid ArthritisDeregulated Nutrient SensingRetinol-binding protein 4 in rheumatoid arthritis-related insulin resistance and b-cell function.24532832
Obesity, Diabetes MellitusDeregulated Nutrient SensingRetinol-binding protein 4 (RBP4), an adipokine related to impaired glucose tolerance, has been associated with insulin resistance (IR) and b-cell function in subjects with obesity or diabetes.24532832
Thrombophilia, Atherosclerosis, Dyslipidemias, Hypothyroidism, Saint Helena IslandsDeregulated Nutrient SensingSubclinical hypothyroidism (SH) is associated with increased risk for atherosclerosis, mainly attributable to dyslipidaemia and hypercoagulability.24548294
Dyslipidemias, Lower Urinary Tract Symptoms, Angina Pectoris, Diabetes MellitusDeregulated Nutrient SensingPredictors of ED remission were lower age, current employment, and absence of voiding LUTS, angina, diabetes, and dyslipidemia.24548342
Cancer-related fatigueDeregulated Nutrient SensingIn conclusion, among abdominally obese women, WC and CRF are independently associated with measures of glucose tolerance and insulin resistance and mediate the association between MVPA and insulin resistance.24552378
Primary malignant neoplasm, Breast CarcinomaDeregulated Nutrient SensingWe recently established a pre-clinical model of estrogen-dependent MCF-7 breast cancer cells that were chronically adapted to grow (> 10 months) in the presence of graded, millimolar concentrations of the anti-diabetic biguanide metformin, an AMPK agonist/mTOR inhibitor that has been evaluated in multiple in vitro and in vivo cancer studies and is now being tested in clinical trials.24553122
Chronic Kidney DiseasesDeregulated Nutrient SensingUsing a cross-sectional survey of adults living in a middle-income neighborhood of Dhaka, Bangladesh, we tested the hypothesis that the prevalence of CKD in this group would approach that of the U.S. and would be strongly associated with insulin resistance.24555767
Chronic Kidney DiseasesDeregulated Nutrient SensingA participant with insulin resistance had a 3.6-fold increase in odds of CKD (95% confidence interval 2.1 to 6.4).24555767
Chronic Kidney DiseasesDeregulated Nutrient SensingWe found an alarmingly high prevalence of CKD--particularly CKD associated with insulin resistance-in middle-income, urban Bangladeshis.24555767
Dyslipidemias, Depression, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThis study provides insight into the potential risk factors for diabetes such as the presence of obesity, dyslipidemia, and depression, specifically in patients with HbA1c levels above 9%.24556384
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingNo correlations were found between the CCT and dyslipidemia, diabetes, or hypertension.24556853
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingNo associations were found between the CCT and dyslipidemia, diabetes, or hypertension.24556853
Inflammation, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, physiopathologicalDeregulated Nutrient SensingInflammation, insulin resistance and vascular dysfunction characterize obesity and predict development of cardiovascular disease (CVD).24559846
Dyslipidemias, diabeticDeregulated Nutrient SensingSerum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1years.24560422
DeficitDeregulated Nutrient SensingWe further set out to determine if pharmacological activation of 5'-AMP-activated protein kinase (AMPK) might counteract any of these functional deficits.24561866
Peripheral Vascular InsufficiencyDeregulated Nutrient SensingExercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.24561866
Muscle fatigabilityDeregulated Nutrient SensingTreatment of animals with an AMPK activator, R118, increased voluntary wheel running activity, decreased muscle fatigability, and prevented the progressive decrease in treadmill exercise capacity.24561866
Intermittent Claudication, Peripheral Vascular Insufficiency, Impaired exercise toleranceDeregulated Nutrient SensingThese data suggest that aged, obese mice represent a novel model for studying exercise intolerance associated with peripheral vascular insufficiency, and pharmacological activation of AMPK may be a suitable treatment for intermittent claudication associated with PAD.24561866
Data types - AddressDeregulated Nutrient SensingSuppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD.24567379
Diabetes MellitusDeregulated Nutrient SensingAge-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)].24567379
Cognition DisordersDeregulated Nutrient SensingOlder MG(+)-fed mice, similar to old Reg controls, developed MS, increased brain amyloid-b42, deposits of AGEs, gliosis, and cognitive deficits, accompanied by suppressed SIRT1, nicotinamide phosphoribosyltransferase, AGE receptor 1, and PPARg.24567379
Inflammation, Data types - AddressDeregulated Nutrient SensingThe data identify a specific AGE (MG) as a modifiable risk factor for AD and MS, possibly acting via suppressed SIRT1 and other host defenses, to promote chronic oxidant stress and inflammation.24567379
Data types - AddressDeregulated Nutrient SensingBecause SIRT1 deficiency in humans is both preventable and reversible by AGE reduction, a therapeutic strategy that includes AGE reduction may offer a new strategy to combat the epidemics of AD and MS.24567379
DyslipidemiasDeregulated Nutrient SensingAlthough lifestyle and diet are considered to have a role in global BC incidence pattern, the specific influence of dyslipidemia in BC onset and progression is not yet completely understood.24571647
Dyslipidemias, atherosclerotic, Cardiovascular DiseasesDeregulated Nutrient SensingAtherosclerotic changes associated with dyslipidemia and increased cardiovascular disease risk are believed to begin in childhood.24572253
DyslipidemiasDeregulated Nutrient SensingThere was a declining trend in the prevalence of dyslipidemia and an increasing trend in the rates of use of lipid-lowering medication among Korean adults.24573366
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingRisk factors for PU were hypertension, dyslipidemia, and chronic kidney disease.24574832
Presenile dementia, Impaired cognition, diabeticDeregulated Nutrient SensingEvidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals.24577463
Presenile dementia, Hyperglycemia, Impaired cognitionDeregulated Nutrient SensingFurther studies should establish the role of hyperglycemia and insulin resistance, and the protective role of metformin in the risk of cognitive decline and dementia.24577463
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe positive trends of age-adjusted rates of hypertension and dyslipidemia were significantly steeper in females than in males.24579915
Hypertension, CTCAE, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingSmoking and heavy alcohol consumption were significantly associated with CVD, and increased BMI was significantly associated with hypertension and dyslipidemia among subjects with type 2 diabetes in this study population.24581089
HyperglycemiaDeregulated Nutrient SensingIn elective surgery, postoperative hyperglycaemia and insulin resistance are independent risk factors for complications.24581942
Dyslipidemias, Sleep Apnea, CTCAE, Hypertension, CTCAEDeregulated Nutrient SensingOn average, each patient had 4 co-morbidities preoperatively, with hypertension (n = 49; 86%), dyslipidemia (n = 40; 70%), and sleep apnea (n = 31; 54%) being the most common.24582414
Dyslipidemias, Diabetes Mellitus, Sleep Apnea, CTCAE, Back Pain, Hypertension, CTCAEDeregulated Nutrient SensingThe resolution of hypertension, dyslipidemia, sleep apnea, lower back pain, and non-insulin-dependent diabetes was 27%, 28%, 35%, 31%, and 35%, respectively.24582414
Non-alcoholic Fatty Liver Disease, Inflammation, Obesity, Abdominal, Fatty degenerationDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD), characterized by accumulation of hepatic triglycerides (steatosis), is associated with abdominal obesity, insulin resistance, and inflammation.24582567
Fatty degenerationDeregulated Nutrient SensingResveratrol is a polyphenol that prevents high-energy diet-induced steatosis and insulin resistance in animals by up-regulating pathways that regulate energy metabolism.24582567
Fatty degenerationDeregulated Nutrient SensingEight-week administration of resveratrol did not reduce insulin resistance, steatosis, or abdominal fat distribution when compared with baseline.24582567
Dyslipidemias, Diabetes Mellitus, Cavia, Hypertension, CTCAE, atheroscleroticDeregulated Nutrient Sensing2) Among the control subjects, the CAVI values in the subjects with atherosclerotic risk factors (hypertension, dyslipidemia and/or diabetes) were significantly higher than those observed in the subjects without risk factors.24583429
NeoplasmsDeregulated Nutrient SensingA reduction in PI3K and mTORC1/mTORC2 pathway signaling was observed in serial hair sheath cells, skin, and tumor samples.24583798
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingMultivariable regression analysis revealed that DM, dyslipidemia, elevated sVEGFR-1, and reduced VEGF and PLGF in serum were independently associated with a low degree of coronary collateralization.24583918
HyperglycemiaDeregulated Nutrient SensingAll severely burned patients exhibited burn-induced insulin resistance and hyperglycemia.24584061
Inflammation, Cardiovascular Diseases, Dyslipidemias, Depressed mood, DiseaseDeregulated Nutrient SensingWe conclude that this study contributes the first evidence of a correlation between marked dyslipidemia and worsened Cu/Zn ratios in HPs, implying an increased risk of diseases associated with elevated oxidative stress, inflammation, and depressed immune function, such as cardiovascular diseases.24585396
Deficiency of butyryl-CoA dehydrogenase, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia (SCAD: 30.8% vs. PR: 63.8% vs. non-SCAD/non-PR: 67.5%, p=0.03) and current smoking (SCAD: 7.7% vs. PR: 57.9% vs. non-SCAD/non-PR: 59.7%, p<0.01) were significantly lower in the SCAD group.24585938
Inflammation, Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingComparison of efficacy of intensive versus mild pitavastatin therapy on lipid and inflammation biomarkers in hypertensive patients with dyslipidemia.24586502
Inflammation, Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThis study assigned essential hypertensive patients with dyslipidemia to 6 months administration of mild (1 mg/day, n = 34) or intensive pitavastatin therapy (4 mg/day, n = 29), and various lipid and inflammation biomarkers were measured at baseline, and 3 and 6 months after the start of treatment.24586502
ObesityDeregulated Nutrient SensingLower levels have been observed in obesity, insulin resistance, and in critical illness.24586568
Inflammation, Dyslipidemias, HIV Infections, AtherosclerosisDeregulated Nutrient SensingThe increased immune activation and inflammation of chronic HIV-infection and the characteristic dyslipidemias associated with HIV infection and antiretroviral therapy (ART) contribute to an increased risk of atherosclerotic vascular disease among HIV-infected adults.24586854
TG gene, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia is a common feature in patients with PM that is characterized by a decrease in HDL-C and an increase in TG, suggesting a high risk of atherosclerosis.24587064
Immune dysregulationDeregulated Nutrient SensingMonocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.24587328
Metabolic Syndrome X, HIV InfectionsDeregulated Nutrient SensingMO, and specifically classical MO, may contribute to insulin resistance and metabolic syndrome during chronic HIV infection.24587328
Cardiovascular DiseasesDeregulated Nutrient SensingSIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases.24587358
Pentalogy of CantrellDeregulated Nutrient SensingThis is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSI.24587358
Diabetes MellitusDeregulated Nutrient SensingThe TyG index, a simple measure reflecting insulin resistance, might be useful in identifying individuals at high risk of developing diabetes.24587359
Triglycerides, Carotid Artery Plaque, Dyslipidemias, ObesityDeregulated Nutrient SensingObesity, high triglycerides, and dyslipidemia were not associated with carotid artery plaque or cIMT.24588080
Endothelial dysfunctionDeregulated Nutrient SensingCompared with non-ED group, WME-NS group had higher prevalence of early ED risk factors including endothelial dysfunction, insulin resistance, high level of glycosylated serum protein and abnormal NPTR.24589222
Cardiovascular Diseases, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia is one of the primary causes for cardio vascular disease (CVD) and development of myocardial infarction (MI) which often leads to coronary artery disease (CAD).24592787
Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingAlthough data suggest that the ratio of leptin/adiponectin correlates with insulin resistance and predicts cardiovascular disease (CVD), there is scanty data on the relationship between the retinol-binding protein-4 (RBP4)/adiponectin ratio with insulin resistance and inflammation.24593134
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingIt has been attributed, among other causes, to hypertension and dyslipidemia.24593225
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo analyse the efficacy of low-dose rosuvastatin for treating hypo high-density lipoprotein (HDL) cholesterolaemia in patients with type 2 diabetes and dyslipidaemia.24595147
Kidney Failure, ChronicDeregulated Nutrient SensingDo insulin resistance conditions further impair the lipid and inflammatory profile in end-stage renal disease patients on hemodialysis?24601848
HD Term TypeDeregulated Nutrient SensingNeither was the proinflammatory profile further altered in HD patients in the presence of insulin resistance conditions.24601848
OverweightDeregulated Nutrient SensingAmong overweight children, an increase of 10 ng perfluorooctane sulfonic acid/mL plasma was associated with 16.2% (95% confidence interval [CI], 5.2%-28.3%) higher insulin concentration, 12.0% (95% CI, 2.4%-22.4%) higher b-cell activity, 17.6% (95% CI, 5.8%-30.8%) higher insulin resistance, and 8.6% (95% CI, 1.2%-16.5%) higher triglyceride concentrations, and an increase of 10 ng perfluorooctanoic acid/mL plasma was associated with 71.6% (95% CI, 2.4%-187.5%) higher insulin concentration, 67.5% (95% CI, 5.5%-166.0%) higher b-cell function, 73.9% (95% CI, 0.2%-202.0%) higher insulin resistance, and 76.2% (95% CI, 22.8%-153.0%) higher triglyceride concentrations.24606078
Units Of Measure - Siemens, Obesity, Diabetes MellitusDeregulated Nutrient SensingAlthough obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese (MHO) appears relatively protected from the development of cardiometabolic complications.24606089
ProteinuriaDeregulated Nutrient SensingInhibition of AGE formation in db/db mice by pyridoxamine treatment attenuated proteinuria and podocyte injury, restored SIRT1 expression, and reduced p65 and STAT3 acetylation.24608443
Proteinuria, Injury of kidney, diabeticDeregulated Nutrient SensingDiabetic db/db mice with conditional deletion of SIRT1 in podocytes developed more proteinuria, kidney injury, and acetylation of p65 and STAT3 compared with db/db mice without SIRT1 deletion.24608443
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia and insulin resistance, especially when are associated with elevate values of ALT level, are strong independent risk factors in developing NAFLD/NASH.24608579
ObesityDeregulated Nutrient SensingFibroblast growth factor (FGF)-21 has recently been introduced as a circulating adipokine which reverses insulin resistance and obesity in rodents.24612017
Dyslipidemias, Data types - Address, diabeticDeregulated Nutrient SensingThe Discriminant Ratio (DR) methodology was used in 120 type 2 diabetic patients in order: (i) to compute TRL-C from non-fasting lipids; (ii) to establish the performance of TRL-C and TRL-C/apoA-I (vs. TG-based markers) to grade TRLs and atherogenic dyslipidemia (AD); and (iii) to relate TRL-C with non-fasting TG.24612479
Fatty LiverDeregulated Nutrient SensingAn increase in insulin resistance predicted a 2-fold increased prevalence of fatty liver in all ethnicities after multivariable adjustment.24613289
Dyslipidemias, SarcopeniaDeregulated Nutrient SensingSarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men: the 2008-2010 Korea National Health and Nutrition Examination Survey.24615361
Dyslipidemias, Sarcopenia, ObesityDeregulated Nutrient SensingHowever, it remains unclear whether SO has greater adverse effects on dyslipidemia than on sarcopenia or obesity alone.24615361
Dyslipidemias, Sarcopenia, ObesityDeregulated Nutrient SensingIn Korean elderly men, SO was associated with an increased risk for dyslipidemia compared with sarcopenia or obesity alone.24615361
Dyslipidemias, atherosclerotic, AtherosclerosisDeregulated Nutrient SensingAfter the publication of the new guidelines of the European Society of Cardiology and the European Atherosclerosis Society for the prevention and treatment of dyslipidemias (Eur Heart J 32:1769-1818, 2011; Eur Heart J 33:1635-1701, 2012), a group of authors has recently published on behalf of the American Heart Association and the American College of Cardiology guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk (Circulation 2013).24615676
Gestational Diabetes, Glucose Intolerance (disease), Fatty degenerationDeregulated Nutrient SensingHepatic rather than cardiac steatosis relates to glucose intolerance in women with prior gestational diabetes.24621572
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingDyslipidemia and outcome in patients with acute ischemic stroke.24625400
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingTo study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke.24625400
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingEffect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively.24625400
Dyslipidemias, Inappropriate behaviorDeregulated Nutrient SensingThe diagnosis of dyslipidemia requires >=2 high lipid values, but inappropriate behavior in the diagnosis of dyslipidemia has only previously been analyzed using just total cholesterol (TC).24626597
CD55 gene, DyslipidemiasDeregulated Nutrient SensingTo determine clinical inertia in the dyslipidemia diagnosis using both TC and high-density lipoprotein cholesterol (HDL-c) and its associated factors.24626597
Diabetes MellitusDeregulated Nutrient SensingThe 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine, has been associated with incident diabetes mellitus and insulin resistance.24627569
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingPatients with NAFLD showed more insulin resistance than healthy controls.24631112
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHowever, physical activity was lower in NAFLD compared with healthy controls and was associated with higher body mass index and insulin resistance.24631112
vascular inflammations, ObesityDeregulated Nutrient SensingObesity and insulin resistance worsen markers of systemic and vascular inflammation.24635342
Dyslipidemias, Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingIn addition to dyslipidemia, immune activation, HIV-replication and an accumulation of risk factors for atherosclerosis, this adverse antibody profile may be of major importance for the increased risk of cardiovascular disease in HIV + individuals.24636004
DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia and associated risk factors in Turkish adults.24636181
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia is a modifiable major risk factor for coronary heart disease.24636181
DyslipidemiasDeregulated Nutrient SensingEnhanced public health preventive measures should be implemented to better diagnose and comprehensively treat dyslipidemia in Turkey.24636181
AHSG protein, humanDeregulated Nutrient SensingFetuin-A was decreased by approximately 8% (pre, 1.01 +- 0.08, vs post, 0.89 +- 0.06 g * L(-1); P < 0.05) after the intervention, and lower fetuin-A after exercise correlated with lower hepatic insulin resistance (r = -0.46, P < 0.01), increased metabolic flexibility (r = -0.70, P < 0.01) and high-molecular weight adiponectin (r = -0.57, P < 0.01).24637346
Inflammation, AHSG protein, humanDeregulated Nutrient SensingFetuin-A may contribute to exercise training-induced improvements in hepatic insulin resistance, CHO utilization, and inflammation in older obese adults.24637346
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingThe dependence of the formation of dyslipidemia and related changes of atherosclerosis in the young age on neuroendocrine effects, accompanying the effects of combat stress and promoting accelerated aging was determined.24640705
No metabolic abnormalities, Cardiovascular DiseasesDeregulated Nutrient SensingVisceral adiposity is linked to the development of insulin resistance, which is a condition that may contribute to metabolic abnormalities and cardiovascular disease.24643468
Obesity, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingWith regard to cardiovascular risk factors, 70.5% of subjects had dyslipidemia, 26.7% hypertension, 24.8% obesity, 8.4% diabetes and 25.5% were smokers.24646328
Dyslipidemias, Antihypertensive AgentsDeregulated Nutrient SensingClinical characteristics of 26 patients were: age 50+-14 (mean+-1SD) years, eGFR 41+-11 ml/min/1.73 m2, males 73%, dyslipidaemia 36%, smokers 23% and hypertensives 87%.24646518
Cardiovascular DiseasesDeregulated Nutrient SensingImpaired adipogenesis and insulin resistance in epicardial fat-mesenchymal cells from patients with cardiovascular disease.24648294
Coronary Artery DiseaseDeregulated Nutrient SensingThe thickness of epicardial adipose tissue (EAT), which is an inflammatory source for coronary artery disease (CAD), correlates with insulin resistance.24648294
physiopathological, Cardiovascular DiseasesDeregulated Nutrient SensingLow adipogenesis ability and insulin resistance in EAT-MCs might shed light on the association between EAT dysfunction and cardiovascular disease.24648294
Dyslipidemias, TOAST ClassificationDeregulated Nutrient SensingOverall, dyslipidemia appears as the leading factor, while TOAST classification does not reach statistical significance.24650199
Dyslipidemias, atherosclerotic, Cerebrovascular accidentDeregulated Nutrient SensingThe presence of dyslipidemia remains the main factor influencing statin prescription, while the presence of well-defined atherosclerotic etiopathogenesis of stroke does not enhance statin prescription.24650199
Acanthosis Nigricans, Skin lesionDeregulated Nutrient SensingAcanthosis nigricans (AN) is an easily identifiable skin lesion and associated with insulin resistance.24650208
ObesityDeregulated Nutrient SensingIndependent of obesity measures, greater fast-food restaurant density was associated with higher insulin resistance.24650840
Diabetes MellitusDeregulated Nutrient SensingReducing access to fast food and increasing public park space may be valuable to addressing insulin resistance and type 2 diabetes, but effects may vary by gender.24650840
Diabetes, Autoimmune, Diabetes MellitusDeregulated Nutrient SensingComparison of adults with insulin resistance (IR) in latent autoimmune diabetes versus IR in glutamic acid decarboxylase antibody-negative diabetes.24652431
Diabetes, AutoimmuneDeregulated Nutrient SensingInsulin resistance in latent autoimmune diabetes in adults (LADA) patients is controversial.24652431
diabeticDeregulated Nutrient SensingThe results showed that LADA patients had higher insulin resistance and high density lipoprotein cholesterol (HDLc) (P = 0.003 and 0.00017 respectively) and lower body mass index (BMI) (P = 0.007) compared to GAD-negative diabetic patients.24652431
TG gene, Hypoalphalipoproteinemia, Familial, diabeticDeregulated Nutrient SensingThe HDLc was associated with decreased insulin resistance in LADA patients (P = 0.041), whereas HbA1c, triacylglycerides (TG) and waist were associated with increased insulin resistance in GAD-negative diabetic patients (P = 3.6x10-12, 1.01x10-5 and 0.004 respectively).24652431
diabeticDeregulated Nutrient SensingInsulin resistance is significantly higher in LADA than GAD-negative diabetic Malaysian subjects.24652431
PeriodontitisDeregulated Nutrient SensingShorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment).24652728
Non-alcoholic Fatty Liver Disease, Carotid Intima-Media ThicknessDeregulated Nutrient SensingAssociation of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents.24656140
Cardiovascular DiseasesDeregulated Nutrient SensingThe triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease.24656140
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08-3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03-15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30-3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62-4.56); P < 0.01].24656140
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingFurthermore, maintained dyslipidemia was a strong predictor for CHD events.24657509
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAberrant brain functional connectivity related to insulin resistance in type 2 diabetes: a resting-state fMRI study.24658392
Alzheimers Disease", Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is characterized by insulin resistance, which is involved in the development of Alzheimer disease.24658392
diabeticDeregulated Nutrient SensingType 2 diabetic patients develop aberrant functional connectivity of the PCC, which is associated with insulin resistance in selected brain regions.24658392
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA high prevalence of diabetes (57%), hypertension (56.6%), dyslipidemia (42%), and smoking (32.4%) was reported.24658552
Congenital Abnormality, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingWe identified novel associations between elevated CETP activity and the triad of quantitative and qualitative lipoprotein abnormalities in the atherogenic dyslipidemia in South Asians, a major contributor of increased atherosclerotic cardiovascular diseases in South Asians.24659026
Colorectal CarcinomaDeregulated Nutrient SensingOmentin is a plasma adipokine that is synthesized in visceral adipose tissue; its plasma concentration changes in colorectal cancer and conditions associated with insulin resistance.24659266
Patent ductus arteriosus - persisting typeDeregulated Nutrient SensingA syndrome of insulin resistance resembling Donohue syndrome with patent ductus arteriosus.24660547
Patent ductus arteriosus - persisting typeDeregulated Nutrient SensingIt is very rare that a syndrome of insulin resistance resembles Donohue syndrome with patent ductus arteriosus.24660547
Patent ductus arteriosus - persisting typeDeregulated Nutrient SensingThis child shows insulin resistance resembling Donohue syndrome with patent ductus arteriosus.24660547
Diabetic Retinopathy, Dyslipidemias, Sex Characteristics, PolyneuropathyDeregulated Nutrient SensingWe report a series of novel OSAS-related sexual dimorphisms, concerning GAD65 auto-antibodies; polyneuropathy; atherogenic dyslipidemia [all increased in females]; diabetic retinopathy; North-Caucasian ethnicity; metabolic control; and TIA/stroke prevalence [all lower in females].24661757
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingClustering of cardiometabolic risk factors was defined by the existence of 2 or more of high blood pressure, hyperglycemia, and dyslipidemia.24662439
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingLogistic regression analysis was used to establish an association with and prognostic value of vitamin D for the onset of type 2 diabetes mellitus, as well as insulin resistance, body mass index (BMI), total cholesterol and triglyceride levels in the development of diabetes.24662713
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study showed that the patients with postmenopausal OS and hypovitaminosis D, besides a high BMI, elevated triglyceride levels and insulin resistance, had an increased risk of developing type 2 diabetes.24662713
Psoriasis vulgarisDeregulated Nutrient SensingEffect of treatment with methotrexate and coal tar on adipokine levels and indices of insulin resistance and sensitivity in patients with psoriasis vulgaris.24665910
Psoriasis vulgarisDeregulated Nutrient SensingHence, we undertook to study adipokine levels and indices of insulin resistance and sensitivity in patients with psoriasis vulgaris, in comparison with controls and their association with disease severity and response to therapy.24665910
Liver DysfunctionDeregulated Nutrient SensingShe also exhibited insulin resistance and liver dysfunction.24668897
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingIncreased BIF-IMT was associated with dyslipidemia, coronary heart disease and smoking.24669965
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingIncreased ICA-IMT was associated with dyslipidemia and stroke.24669965
Dyslipidemias, Heart failureDeregulated Nutrient SensingEffects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia.24670266
Dyslipidemias, Chronic heart failure, Congestive heart failureDeregulated Nutrient SensingThe effects of eicosapentaenoic acid (EPA) on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear.24670266
DyslipidemiasDeregulated Nutrient SensingOnly patients with dyslipidemia at baseline (entry) were treated with EPA.24670266
Inflammation, Dyslipidemias, Congestive heart failureDeregulated Nutrient SensingThese data indicate that EPA treatment may improve the cardiac function and long-term prognosis of CHF patients with dyslipidemia, at least in part, due to reductions in inflammation and improvements in the endothelial function.24670266
Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingReduced sex hormone-binding globulin (SHBG) concentration predicts insulin resistance and type 2 diabetes, but its association with cardiovascular disease (CVD) risk is unclear.24670886
Dyslipidemias, Diabetes Mellitus, Hepatitis C, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingOverall, female gender, older age, non-white race/ethnicity, and pre-existing hypertension, dyslipidaemia, obesity and hepatitis C infection were associated with higher risk of diabetes incidence.24673640
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient Sensing(1) Statistical difference was observed in dyslipidemia, hypertension and the history of diabetes in the two groups (P < 0.05).24674723
OverweightDeregulated Nutrient Sensing[Insulin resistance in adolescents with and without overweight of a municipality of Great Florianopolis-SC].24676067
Overweight, Diabetes MellitusDeregulated Nutrient SensingIncreased overweight prevalence among adolescents is linked to Diabetes mellitus type 2 and insulin resistance (IR).24676067
Urolithiasis, DyslipidemiasDeregulated Nutrient SensingTo assess the association between dyslipidemia and urolithiasis, a propensity score-matching study was performed.24684546
Dyslipidemias, DiseaseDeregulated Nutrient SensingThe controls, from a health-screening program, did not have a history of dyslipidemia or statin use and have any evidence of stone disease, as determined by abdominal radiography, ultrasonography examination.24684546
Urinary Calculi, DyslipidemiasDeregulated Nutrient SensingOur study implies that dyslipidemia may play a crucial part in urinary stone risk.24684546
Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAE, ComorbidityDeregulated Nutrient SensingHypertension, diabetes, ischemic heart disease, dyslipidaemia and respiratory problem were significantly associated co-morbid conditions in stroke patients (at 95% CI, p value is <0.001, <0.01, <0.001, <0.05, <0.05 respectively).24684800
Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingFrom non-obese children, children under general-obesity, abdominal obesity and those with combined types of obesity, there appeared an increasing trend in the levels of blood pressure, blood glucose, and blood lipids, the prevalence dyslipidemia and hypertension (P < 0.001).24685027
Cancer-related fatigue, Obesity, Abdominal, Dyslipidemias, ObesityDeregulated Nutrient SensingAfter controlling for age, sex, and puberty stage, when compared with non-obese children, those children with abdominal obesity or combined types of obesity had 1.54 and 2.51 times of risks to only one CRF, while generally obese children had similar risk of dyslipidemia.24685027
Hypoglycemia, Diabetes MellitusDeregulated Nutrient SensingBiochemical hypoglycaemia during an OGTT in the absence of diabetes or IGR was not associated with insulin resistance, but instead appeared to be associated with more favourable glycaemic risk profiles than IGR and NGT.24685116
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingObservational data suggest that hyperglycaemia, hypertension and dyslipidaemia might be involved in the causal pathway underlying this link, but data from the ACCORD MIND investigators challenge these findings.24686200
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels: potential targets for an efficient preventive intervention.24686488
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingTherefore, in this study we compared the levels of insulin resistance (IR:OGIS), plasma insulin (PI:RIA) levels, and pro-inflammatory cytokines (IL-6 and TNF-a: ELISA), being risk factors previously found to be associated with hypertension, in T2D patients showing increased body weight (obese and overweight, BMI >= 25 kg/m2) with hypertension (group A, N = 30), or without hypertension (group B, N = 30), and in nonobese (BMI < 25 kg/m2), normotensive controls (group C, N = 15).24686488
Non-alcoholic Fatty Liver Disease, Steatohepatitis, Weight decreasedDeregulated Nutrient SensingThe addition of exercise to a diet regimen potentiates the benefits in NAFLD management through further improvement of hepatic steatosis, inflammatory and oxidative stress levels, and adipokine imbalance, thereby attenuating insulin resistance independent of detectable weight loss.24689911
Glucose Intolerance (disease), Breast CarcinomaDeregulated Nutrient SensingOn the status and comparison of glucose intolerance in female breast cancer patients at initial diagnosis and during chemotherapy through an oral glucose tolerance test.24690937
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingAssociated profile: female (OR=0.460, P=0.091), no dyslipidemia (OR=0.393, P=0.048), no coronary heart disease (OR=0.215, P=0.001) and high diastolic blood pressure (OR=1.076, P=0.016).24694801
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAssociated profile: male (OR=1.610, P=0.089), smoking (OR=2.055, P=0.045), dyslipidemia (OR=3.227, P<0.001) and diabetes (OR=2.795, P<0.001).24694801
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study reports association of CDKAL1-related SNPs with insulin resistance, a clinical marker related to type 2 diabetes in a cross-sectional cohort of Greek children and adolescents of European descent.24695378
Glucose Intolerance (disease)Deregulated Nutrient SensingBoth glucose intolerance and HbA(1c) levels increased with age.24698119
Ventricular hypertrophyDeregulated Nutrient SensingLeft ventricular hypertrophy and insulin resistance in adults from an urban community in The Gambia: cross-sectional study.24705608
Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingTo determine the association between left ventricular hypertrophy and insulin resistance in Gambians.24705608
Electrocardiogram: left ventricle hypertrophy (finding)Deregulated Nutrient SensingLogistic regression analysis was used to determine the association between left ventricular hypertrophy and insulin resistance.24705608
Antihypertensive Agents, Ventricular hypertrophyDeregulated Nutrient SensingNo association was found in this study between left ventricular hypertrophy and insulin resistance in Gambians and this does not support the suggestion that insulin is an independent determinant of left ventricular hypertrophy in hypertensives.24705608
Liver Dysfunction, Liver CirrhosisDeregulated Nutrient SensingInsulin resistance as early sign of hepatic dysfunction in liver cirrhosis.24705764
Glucose Intolerance (disease), Liver DysfunctionDeregulated Nutrient SensingAll patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed.24705764
Liver parenchyma, Saint LuciaDeregulated Nutrient SensingInsulin resistance in both liver and peripheral tissues is the early sign in the patients with LC.24705764
Increased insulin level, Glucose Intolerance (disease), Saint Lucia, Hyperglycemia, Postprandial, Liver CirrhosisDeregulated Nutrient SensingGlucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC).24705764
Saint Lucia, Glucose Intolerance (disease), Liver functionDeregulated Nutrient SensingThe aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC.24705764
Electrocardiogram: myocardial infarction (finding), Myocardial ReperfusionDeregulated Nutrient SensingAcute insulin resistance in ST-segment elevation myocardial infarction in non-diabetic patients is associated with incomplete myocardial reperfusion and impaired coronary microcirculatory function.24708817
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingInsulin resistance (IR) assessed by the Homeostatic Model Assessment (HOMA) index in the acute phase of myocardial infarction in non-diabetic patients was recently established as an independent predictor of intrahospital mortality.24708817
ObesityDeregulated Nutrient SensingThe aim of the present study was to examine to what extent different social network mechanisms are involved in the pathogenesis of obesity and insulin-resistance.24710599
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingSocial network phenomena appear not only to be relevant for the spread of obesity, but also for the spread of insulin resistance as the basis for type 2 diabetes.24710599
DyslipidemiasDeregulated Nutrient SensingDyslipidemia was a most common risk factor present in 83% patients.24713427
Hypertension, CTCAE, Atherosclerosis, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHypertension and dyslipidemia were the most common risk factors and large vessel atherosclerosis was the most common stroke etiology.24713427
Juvenile acne, Dyslipidemias, ObesityDeregulated Nutrient SensingBased on clinical, histopathological and paraclinical examinations, we established the following diagnoses: ulcerated NL, type 1 DM, moderate mixed dyslipidemia, class I obesity; commissural candidiasis, juvenile acne.24715184
Depression, CTCAEDeregulated Nutrient SensingInsulin resistance and other cardio-metabolic risk factors predict increased risk of depression and decreased response to antidepressant and mood stabilizer treatments.24715548
Prostate carcinomaDeregulated Nutrient SensingTorc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models.24715588
Diabetes MellitusDeregulated Nutrient SensingThe [(13)c]glucose breath test is a reliable method to identify insulin resistance in Mexican adults without diabetes: comparison with other insulin resistance surrogates.24716853
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) precedes type 2 diabetes, but tests used to detect it in clinical settings reported poor reproducibility.24716853
Arterial StiffnessDeregulated Nutrient SensingObese children and adolescents have elevated nighttime blood pressure independent of insulin resistance and arterial stiffness.24717420
Arterial StiffnessDeregulated Nutrient SensingObese children had a higher nighttime BP when compared with the control group independently of insulin resistance and arterial stiffness.24717420
Arterial StiffnessDeregulated Nutrient SensingNo relationship was found between insulin resistance and arterial stiffness.24717420
Asthma, Dyslipidemias, Depression, CTCAEDeregulated Nutrient SensingThe diagnosis of obesity-related conditions increased significantly with increasing BMI, with 33.5% of obese participants diagnosed with asthma, 7.9% diagnosed with dyslipidemia, and 7.2% diagnosed with depression.24717817
PrehypertensionDeregulated Nutrient SensingThe AGT and the GNB3 polymorphisms and insulin resistance in prehypertension.24722130
Hypertensive (finding)Deregulated Nutrient SensingSimilarly, increased insulin resistance and lipidemia were more common in the hypertensive and prehypertensive populations.24722130
Communicable Diseases, Infection, HyperglycemiaDeregulated Nutrient SensingIncreased risk of infection following hyperglycemia has been reported in hospitalized patients and infections may also cause insulin resistance which complicates the control of blood glucose level.24727515
DyslipidemiasDeregulated Nutrient SensingOver the course of 96 weeks, RPV-based therapy was associated with lower increases in lipid parameters and fewer dyslipidemia AEs than EFV-based treatment.24729492
Neurodegenerative DisordersDeregulated Nutrient SensingInsulin resistance and gray matter volume in neurodegenerative disease.24735819
Neurodegenerative Disorders, palladium, Presenile dementia, Data types - Address, physiopathologicalDeregulated Nutrient SensingThis cross-sectional study suggests that insulin resistance is increased in neurodegenerative disease, and that individuals with AD appear to have more severe metabolic dysfunction than individuals with PD or PD dementia.24735819
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia and residual cardiovascular risk in statin-treated patients.24736236
DyslipidemiasDeregulated Nutrient SensingAt least part of that risk may be attributable to atherogenic dyslipidemia characterized by low high-density lipoprotein cholesterol (<=40 mg/dL) and high triglycerides (triglycerides>=150 mg/dL).24736236
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingThe presence of atherogenic dyslipidemia was associated with higher residual cardiovascular risk in PERFORM and SPARCL subjects with stroke or transient ischemic attack receiving statin therapy.24736236
Diabetes MellitusDeregulated Nutrient SensingAssociation of hematological parameters with insulin resistance in type 1 diabetes.24736486
Diabetes MellitusDeregulated Nutrient SensingIn a multiple logistic regression analysis after adjustment for age, sex, duration of diabetes and BMI, the presence of insulin resistance was independently associated with WBC count (odds ratio=1.28, P<0.01).24736486
InflammationDeregulated Nutrient SensingThe significant independent association of WBC with the presence of insulin resistance suggests a role of subclinical inflammation in its pathogenesis.24736486
Structure of beta Cell of islet, Hyperactive behavior, ImpairedDeregulated Nutrient SensingPancreatic b-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.24740570
B-LymphocytesDeregulated Nutrient SensingUsing a mouse model with b-cell-specific deletion of Tsc2 (bTsc2(-/-)) and, consequently, mTORC1 hyperactivation, we focused on the role that chronic mTORC1 hyperactivation might have on b-cell failure.24740570
HyperglycemiaDeregulated Nutrient SensingmTORC1 hyperactivation drove an early increase in b-cell mass that later declined, triggering hyperglycemia.24740570
B-Lymphocytes, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingWe provide evidence of b-cell autophagy impairment as a link between mTORC1 hyperactivation and mitochondrial dysfunction that probably contributes to b-cell failure.24740570
Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingRenalase might be associated with hypertension and insulin resistance in Type 2 diabetes.24742207
melanomaDeregulated Nutrient SensingSIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.24742694
NeoplasmsDeregulated Nutrient SensingSIRT1 operates as both a tumor suppressor and oncogenic factor depending on the cell context.24742694
melanomaDeregulated Nutrient SensingWhether SIRT1 plays a role in melanoma biology remained poorly elucidated.24742694
melanomaDeregulated Nutrient SensingHere, we demonstrate that SIRT1 is a critical regulator of melanoma cell proliferation.24742694
melanomaDeregulated Nutrient SensingSIRT1 over-expression relieves the senescence-like phenotype and the proliferation arrest caused by MITF suppression, demonstrating that SIRT1 is an effector of MITF-induced proliferation in melanoma cells.24742694
melanomaDeregulated Nutrient SensingInterestingly, SIRT1 level and activity are enhanced in the PLX4032-resistant BRAF(V600E)-mutated melanoma cells compared with their sensitive counterpart.24742694
melanomaDeregulated Nutrient SensingSIRT1 inhibition decreases melanoma cell growth and rescues the sensibility to PLX4032 of PLX4032-resistant BRAF(V600E)-mutated melanoma cells.24742694
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingHypertension, type 2 diabetes mellitus, impaired glucose tolerance, and dyslipidemia were of a similar frequency in both groups.24743396
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingShe had a background of diabetes mellitus, hypertension and dyslipidaemia.24744069
Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingAssociation of dietary factors with insulin resistance and inflammatory markers in subjects with diabetes mellitus and coronary artery disease in Indian population.24746438
Inflammation, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) and inflammation have been implicated in pathogenesis of diabetes and cardiovascular disease.24746438
InflammationDeregulated Nutrient SensingDietary factors have been reported to be associated to insulin resistance and inflammation.24746438
Neurobehavioral Manifestations, Depression, CTCAEDeregulated Nutrient SensingDifferential association of insulin resistance with cognitive and somatic symptoms of depression.24754892
Neurobehavioral Manifestations, Bipolar DisorderDeregulated Nutrient SensingTo examine the associations of depressive symptoms with insulin resistance, evaluating somatic and cognitive depressive symptoms separately.24754892
Bipolar Disorder, CognitiveDeregulated Nutrient SensingSomatic depressive symptoms seem to be more strongly associated with insulin resistance than do cognitive depressive symptoms.24754892
Bipolar Disorder, Depressed mood, CognitiveDeregulated Nutrient SensingMonitoring somatic depressive symptoms may be more appropriate than monitoring cognitive depressive symptoms among depressed individuals with high insulin resistance.24754892
Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient Sensing[Association between serum lipoprotein lipase level and dyslipidemia in patients with obstructive sleep apnea syndrome].24754980
Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient SensingTo explore the association between serum lipoprotein lipase (LPL) level and dyslipidemia in patients with obstructive sleep apnea syndromes (OSAS).24754980
Sleep Apnea, Obstructive, DyslipidemiasDeregulated Nutrient SensingThus LPL may play some roles in dyslipidemia of OSAS patients.24754980
Inflammation, Heart failureDeregulated Nutrient SensingVarious adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation.24755035
Liver Dysfunction, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingSubjects with the C5 variant had higher age, lower body mass index, milder dyslipidemia and liver dysfunction, and lower rates of hypertension and CAD compared with subjects without the C5 variant.24755128
Hepatitis CDeregulated Nutrient SensingThe impact of pegylated interferon and ribavirin combination treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients.24757657
Carcinogenic Chlorinated Hydrocarbon, Hepatitis CDeregulated Nutrient SensingLipid profile and insulin resistance (IR) are associated with hepatitis C virus (HCV) and may predict the chronic hepatitis C (CHC) treatment response.24757657
SialorrheaDeregulated Nutrient SensingFurthermore, eradication of HCV may improve whole-body IR and insulin hypersecretion, as well as high baseline insulin resistance (HOMA-IR >2.5).24757657
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingPatients with non-alcoholic fatty liver had higher (p < 0.001) mean values of urinary 8-iso-PGF2a and of serum soluble NOX2-derived peptide, alanine aminotransferase, Cytokeratin-18 and homeostasis model of insulin resistance and lower values of serum adiponectin as compared to those without.24758604
Diabetes MellitusDeregulated Nutrient SensingComplement factor 3 is associated with insulin resistance and with incident type 2 diabetes over a 7-year follow-up period: the CODAM Study.24760264
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImmune dysregulation can affect insulin resistance (IR) and b-cell function and hence contribute to development of type 2 diabetes mellitus (T2DM).24760264
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe objectives of the study were to determine dyslipidaemia prevalence in first episode coronary heart disease cases and to determine the pattern of distribution of risk factors in this temporal relationship.24761497
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingDyslipidaemia was present in 67.6% of first episode coronary heart disease cases.24761497
Heart Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHeart disease patients with history of diabetes showed a high prevalence of dyslipidaemia (100%), the association being statistically significant (p = 0.008).24761497
OverweightDeregulated Nutrient SensingCompared with overweight children, those who were obese were more likely to have the two conditions: acanthosis nigricans (59% vs 44%; P=0.005) and insulin resistance (35% vs 19%; P=0.001).24762331
Acanthosis NigricansDeregulated Nutrient SensingObese Chinese children and adolescents with acanthosis nigricans had a higher chance of having insulin resistance and cardiometabolic co-morbidities.24762331
Non-alcoholic Fatty Liver Disease, Weight decreased, HypertransaminasaemiaDeregulated Nutrient SensingWe showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hypertransaminasemia and insulin resistance in NAFLD patients.24763885
Obesity, diabeticDeregulated Nutrient SensingAlthough previous studies have indicated that insulin resistance may play a role in the pathogenesis of both lesions in diabetic and obese patients, we found no indication of a relationship in nondiabetic and nonobese patients with increased levels of EGF in patients with ST, suggesting an alternative pathogenesis in this patient group.24763889
Senile sclerosis of aortic cuspDeregulated Nutrient SensingInsulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis.24767168
Senile sclerosis of aortic cuspDeregulated Nutrient SensingHowever, in patients with aortic valve sclerosis (AVS), the association between insulin resistance and subclinical impairment of LV function is not fully elucidated.24767168
Left Ventricular Hypertrophy, physiopathological, Obesity, VisceralDeregulated Nutrient SensingInsulin resistance is a powerful independent predictor of subclinical LV dysfunction regardless of concomitant visceral obesity and LV hypertrophy.24767168
Glucose Intolerance (disease)Deregulated Nutrient SensingWe aimed to elucidate the risk factors for the development of NODM and those for progressive glucose intolerance in adult living-donor liver transplant (LDLT) recipients.24767367
Glucose Intolerance (disease)Deregulated Nutrient SensingNODM and post-transplantation glucose intolerance had no negative impact on patient and graft outcomes.24767367
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn stepwise logistic regression analysis adjusted for diabetes, hypertension, dyslipidemia and age, visfatin (p=0.026) and ghrelin (p=0.012) proved to be independent predictors of AIS.24768795
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingFactors associated with therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia.24769787
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia are the most prevalent cardiovascular risk factors, with approximately 30 million patients in the United States having these concomitant conditions.24769787
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThese variations in therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia across different BMI groups suggest that future research is needed to determine the underlying reasons for these disparities.24769787
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingAssociation between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck.24769813
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingAMP-activated protein kinase (AMPK) regulates glucose and lipid metabolism via the phosphorylation and subsequent inactivation of its downstream target acetyl-CoA carboxylase (ACC).Thus, we analyzed the expression of pAMPK and its downstream target phosphorylated acetyl-CoA carboxylase (pACC), as well as their impact on the survival of patients with resected SCCHN.24769813
Behavior, Primary malignant neoplasmDeregulated Nutrient SensingFor example, the LKB1-AMPK-mTOR signaling pathway genes are already known to alter the cell metabolism and to play a critical role in the malignant behavior of cancer.24770722
ObesityDeregulated Nutrient SensingDysregulation of 11b-hydroxysteroid dehydrogenase (11b-HSD) enzyme activities are implicated in the pathogenesis of obesity and insulin resistance.24771091
Inflammation, ThrombosisDeregulated Nutrient SensingInflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis.24772446
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHypertension (49%) and dyslipidemia (36%) were the most common underlying cardiovascular diseases (CVDs).24772588
Atrial Fibrillation, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingFor Thai patients with AF, hypertension and dyslipidemia were the most common underlying CVDs, and rate control was the preferred treatment strategy.24772588
DyslipidemiasDeregulated Nutrient SensingMean BMI was 26.8 +/- 4.7 kg/m2, co-morbid diseases were as follows; DM, 68 patients (57.1%) and dyslipidemia 67 patients (56.3%).24772590
Vascular Diseases, DyslipidemiasDeregulated Nutrient SensingPatients with porcelain aorta more frequently had extracardiac vascular disease (11 [30.6%] vs 49 [11.9%]; P=.002), prior coronary revascularization (15 [41.7%] vs 98 [23.7%]; P=.017), and dyslipidemia (26 [72.2%] vs 186 [45%]; P=.02).24773857
Dyslipidemias, Obesity, Choline Dehydrogenase, Mitochondrial, Asthma, Hypertension, CTCAEDeregulated Nutrient SensingRFs, such as female gender, family history, hypertension, obesity and dyslipidemia play an important role in the development of asthma concurrent with CHD.24779068
InflammationDeregulated Nutrient SensingResistin is an adipocytokine that has been related to inflammation and insulin resistance.24780007
Degenerative polyarthritis, ETV3 wt AlleleDeregulated Nutrient SensingThe association between MetS and radiographic knee OA can be largely explained by an excessive weight but not by insulin resistance, a key pathophysiology of MetS.24780047
Hepatitis CDeregulated Nutrient SensingTaken together, this study provided information on the proteome profile of the HCV-infected Indian population, and revealed a link between HCV infection, RBP4 and insulin resistance.24784414
Diabetes MellitusDeregulated Nutrient SensingEffects of age on insulin resistance and secretion in subjects without diabetes.24785884
Hypertensive (finding), Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPersistent lipid abnormalities in patients with hypertension and dyslipidemia treated with statins: results of the Portuguese hypertensive subpopulation of the Dyslipidemia International Study (DYSIS).24785978
Vascular Diseases, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOther traditional CRFs (hypertension, dyslipidaemia, smoking, age and family history of vascular disease) were not associated with CAD severity.24786377
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingWe tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the role of the total cholesterol/HDL cholesterol (TC/HDL-C) ratio as a biological marker of coronary artery disease.24788070
Metabolic Syndrome XDeregulated Nutrient SensingMetabolic syndrome, but not insulin resistance, is associated with an increased risk of renal function decline.24792685
Dyslipidemias, OverweightDeregulated Nutrient SensingAssociation between alcohol intake, overweight, and serum lipid levels and the risk analysis associated with the development of dyslipidemia.24793348
Dyslipidemias, OverweightDeregulated Nutrient SensingTo study the association of alcoholic intake, overweight, and dyslipidemia.24793348
Fatty Liver, Dyslipidemias, Hyperuricemia, Diabetes MellitusDeregulated Nutrient SensingMetabolically unhealthy individuals were defined as people with biological features of dyslipidemia, hyperuricemia, diabetes, and/or hepatitis steatosis.24794756
Hyperglycemia, diabetic, Cerebral Small Vessel Diseases, Hypoglycemia, Brain InjuriesDeregulated Nutrient SensingTo avoid brain injury in diabetic elderly patients, management of hypoglycemia, hyperglycemia, fluctuation of blood glucose, insulin resistance, and cerebral vessel disease is crucial.24796099
Prediabetes syndrome, AnhidrosisDeregulated Nutrient SensingSeveral studies have identified a link between sudomotor dysfunction, insulin resistance, and pre-diabetes.24798863
Gastrointestinal inflammation, Ulcerative ColitisDeregulated Nutrient SensingRBP-4 serum levels were also high in acute and chronic intestinal inflammation in UC and CD, which can support insulin resistance.24799023
Non-alcoholic Fatty Liver Disease, Hypertension, CTCAEDeregulated Nutrient SensingAfter controlling for age, sex, BMI, waist circumference, hypertension, serum HDL, triglyceride and CRP level and insulin resistance, Hispanics of Mexican origin remained significantly more likely to have NAFLD than those of Dominican and Puerto Rican origin.24803810
TG gene, Dyslipidemias, AURKAIP1 geneDeregulated Nutrient SensingDyslipidemia in group 3 was demonstrated by higher TG levels, lipid ratios and AIP and lower HDL-C levels compared with group 2.24804368
Diabetes MellitusDeregulated Nutrient SensingIn total, 25% of the probands had elevated homeostatic assessment of insulin resistance values, and 58.3% of these had evidence of concomitant Type 2 diabetes in their family.24804978
Inflammation, Units Of Measure - SiemensDeregulated Nutrient SensingConsidering insulin resistance and inflammation, the prevalence of MHO was 38.4%.24811744
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSleep duration and insulin resistance in individuals without type 2 diabetes: the PPP-Botnia study.24813456
Sleeplessness, Sleep Apnea, CTCAE, Diabetes MellitusDeregulated Nutrient SensingWe studied if short and long sleep durations were associated with insulin resistance (IR) and insulin secretion in individuals without diabetes, and if the associations remained after we excluded individuals who reported more frequent and severe complaints of sleep apnea and insomnia.24813456
Mitochondrial abnormalitiesDeregulated Nutrient SensingThe mitochondrial abnormalities appear to be caused by decreased activation of the NAD(+)-SIRT1-PGC-1a axis triggered by hyperactivation of the DNA damage sensor PARP-1.24813611
DyslipidemiasDeregulated Nutrient SensingOur results suggest that gender, behavioral factors, and dyslipidemia may affect the risk for developing rectal NETs.24813818
DyslipidemiasDeregulated Nutrient SensingThe findings of this study contribute to a better understanding of the influence of gender, behavioral factors, and dyslipidemia in developing rectal NETs.24813818
Adenocarcinoma of large intestineDeregulated Nutrient SensingClinicopathological significance of SIRT1 expression in colorectal adenocarcinoma.24816737
Colorectal CarcinomaDeregulated Nutrient SensingHowever, the correlations between SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear.24816737
Adenoma, Secondary malignant neoplasm of liver, Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 protein expression in a paraffin-embedded tissue microarray, including 13 benign adenomas, nine liver metastasis tissues, and 120 paired colorectal cancer and normal mucosa tissues, was measured by immunohistochemistry.24816737
Malignant tumor of colonDeregulated Nutrient SensingSIRT1 mRNA and protein expression in colon cancer cell lines with different metastatic potential and normal colon cells were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting.24816737
AdenocarcinomaDeregulated Nutrient SensingThere was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissues (P < 0.01, kh(2) test).24816737
Secondary malignant neoplasm of liverDeregulated Nutrient SensingSIRT1 overexpression was more frequently observed in advanced-stage tumors and lymph node or liver metastases (P = 0.046, 0.002, and 0.004, respectively, kh(2) test).24816737
Aggressive courseDeregulated Nutrient SensingSIRT1 expression was also significantly elevated in the more aggressive colon cancer cell line SW620.24816737
Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 may play an important role in the progression of colorectal cancer.24816737
Metabolic Diseases, Polycystic Ovary Syndrome, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingInsulin resistance (IR) and metabolic disorders are common in polycystic ovary syndrome (PCOS).24816947
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingThe association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined.24816996
Dyslipidemias, Dysglycemia, Obesity, Diabetes MellitusDeregulated Nutrient SensingCommon significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia.24817067
Presenile dementia, Impaired cognitionDeregulated Nutrient SensingInsulin resistance (IR) is a putative risk factor for cognitive decline and dementia, and has been shown to impede neuronal glucose metabolism in animal models.24819305
Hypertriglyceridemia, Hypocholesterolemia, Diabetes MellitusDeregulated Nutrient Sensing(ii) After adjusted for age, individuals with diabetes by OGTT criteria but not by WHO HbA1c criteria had an increased chance of having abnormal weight, hypertriglyceridaemia, HDL hypocholesterolaemia and insulin resistance.24821380
Diabetes MellitusDeregulated Nutrient SensingTriglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes.24824245
Diabetes MellitusDeregulated Nutrient SensingIncident diabetes prevented these improvements, and this was accounted for by differences in weight, insulin resistance, and glucose levels.24824548
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingPhase 3, 12-week, randomized, double-blind, placebo- and ezetimibe-controlled study conducted between January and December of 2013 in patients with primary hypercholesterolemia and mixed dyslipidemia at 198 sites in 17 countries.24825642
Dyslipidemias, Primary hypercholesterolemiaDeregulated Nutrient SensingIn this 12-week trial conducted among patients with primary hypercholesterolemia and mixed dyslipidemia, evolocumab added to moderate- or high-intensity statin therapy resulted in additional LDL-C lowering.24825642
Hypertension, CTCAE, Atherosclerosis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients with more severe atherosclerosis were older (p<0.001), more likely to be obese (p=0.01), smokers (p=0.008) and have hypertension (p=0.001), diabetes (p<0.0001) and dyslipidaemia (p<0.0001).24827532
physiopathologicalDeregulated Nutrient SensingInsulin resistance and higher leptin may be early markers of metabolic dysfunction associated with SSBs.24828025
HypogonadismDeregulated Nutrient SensingThe correlations found between testosterone and four of the five components of MS, as well as with BMI and TG/HDL-chol ratio, a surrogate marker of insulin resistance, suggest considering male hypogonadism as a determinant of developmental abnormalities typical of MS.24828370
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingTherefore, the management of dyslipidemia, together with glucose control, may be beneficial for T2DM with hyperlipidemia.24829924
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingKetosis onset type 2 diabetes had better islet b-cell function and more serious insulin resistance.24829925
KetosisDeregulated Nutrient SensingThis case control study was aimed at comparing the clinical characteristic, b-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection.24829925
KetosisDeregulated Nutrient SensingFrom these data, we concluded that ketosis onset T2DM had better islet b-cell function and more serious insulin resistance than nonketotic onset T2DM.24829925
Metabolic DiseasesDeregulated Nutrient SensingInsulin resistance (IR) is regarded as one of the earliest features of many metabolic diseases, and major efforts are aimed at improving insulin function to confront this issue.24830843
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe gap between the current dyslipidemia guidelines and the physicians' treatment targets in patients with type 2 diabetes in Turkey.24831765
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study evaluated the management of dyslipidemia in patients with type 2 diabetes in real life.24831765
Osage language, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidaemia has been implicated as a mechanism linking OSA with atherosclerosis, but no consistent associations with lipids exist for OSA or positive airway pressure treatment.24833762
Cardiovascular morbidity, Dyslipidemias, Diabetes Mellitus, Malignant Neoplasms, Obesity, Hypertension, CTCAE, DiseaseDeregulated Nutrient SensingThese results suggest that exposure to Holocaust conditions in early life may be associated with a higher prevalence of obesity, dyslipidemia, diabetes, hypertension, cardiovascular morbidity, malignancy and peptic diseases in adulthood.24834754
Erectile dysfunctionDeregulated Nutrient SensingInsulin resistance is an independent predictor of severe lower urinary tract symptoms and of erectile dysfunction: results from a cross-sectional study.24836928
Lower Urinary Tract SymptomsDeregulated Nutrient SensingWe strongly suggest to prevent LUTS and ED by reducing insulin resistance.24836928
ObesityDeregulated Nutrient Sensing[Some peculiarities in the manifestation of oxidative stress and current status of antioxidant system in adolescents of different age groups with obesity, complicated by insulin resistance and without it].24837315
ObesityDeregulated Nutrient SensingObesity with concomitant insulin resistance increases manifestations of oxidative stress accompanied by a compensatory increase in the activity of catabolic enzymes and reduced capacity of the defense antioxidant system in late puberty.24837315
Primary malignant neoplasm, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Electrocardiogram abnormal, Chronic Obstructive Airway Disease, Heart failure, Cessation of life, Hypertension, CTCAEDeregulated Nutrient SensingAfter adjustment for age, gender, race/ethnicity, IHD, heart failure, chronic obstructive pulmonary disease, cancer, diabetes, body mass index, smoking, dyslipidemia, hypertension, use of antihypertensive and lipid-lowering medications, and ECG abnormalities, DTNPV1 was associated with significantly increased risk of all-cause death (HR [95% CI]: 1.30 [1.10, 1.53]; P = 0.002), CVD death (HR [95% CI]: 1.36 [1.08, 1.72]; P = 0.010), and IHD death (HR [95% CI]: 1.36 [1.00, 1.85]; P = 0.047).24837486
Chronic Kidney Diseases, Ventricular hypertrophyDeregulated Nutrient SensingEffects of insulin resistance on left ventricular hypertrophy in patients with CKD stage 1-3.24839054
Diabetes MellitusDeregulated Nutrient SensingHomeostatic model assessment of insulin resistance was calculated in participants without diabetes.24839195
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in addition to diabetes and dyslipidemia in a multivariate analysis.24845468
Diabetes Mellitus, Insulin-Dependent, InsulinDeregulated Nutrient SensingIndividuals with type 1 diabetes may have low IGF-1, related to insulinopenia and insulin resistance.24845759
Bipolar DisorderDeregulated Nutrient SensingDepressive symptom clusters as predictors of 6-year increases in insulin resistance: data from the Pittsburgh Healthy Heart Project.24846000
Prediabetes syndrome, Bipolar DisorderDeregulated Nutrient SensingTo examine longitudinal bidirectional associations between two depressive symptom clusters-the cognitive-affective and somatic-vegetative clusters--and insulin resistance, a marker of prediabetes.24846000
Depression, CTCAE, Fatigue, Dyssomnias, Diabetes MellitusDeregulated Nutrient SensingAmong adults aged 50 to 70 years, the somatic-vegetative symptoms of depression (e.g., fatigue, sleep disturbance, and appetite changes) may worsen insulin resistance and increase diabetes risk, partly, by increasing body mass index.24846000
Osteoporosis, Chronic Kidney Diseases, SarcopeniaDeregulated Nutrient SensingEarly-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008-2009.24846317
Osteoporosis, Kidney Diseases, SarcopeniaDeregulated Nutrient SensingIn this study, we found that insulin resistance, chronic kidney disease stage 3, and osteoporosis at the femur neck were closely associated with sarcopenia in elderly men.24846317
Chronic Kidney Diseases, Osteoporosis, Muscle (organ)Deregulated Nutrient SensingInsulin resistance, chronic kidney disease, and osteoporosis at the femur neck should be modified to prevent the acceleration of skeletal muscle loss in elderly men.24846317
Endotoxemia, SarcopeniaDeregulated Nutrient SensingIn conclusion, insulin resistance and sarcopenia of aging are associated with increased TLR4 expression/signaling, which may be secondary to metabolic endotoxemia.24846769
Hyperhomocysteinemia, Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Congenital heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingHyperglycemia, dyslipidemia and hyperhomocysteinemia are associated with both adult cardiovascular disease (CVD) and having a child with a congenital heart disease (CHD).24847701
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHowever, in the absence of dyslipidaemia, raised CRP can still be considered as a strong predictor of CAD and stroke.24848386
Steatohepatitis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCarriers of the mutation had dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes.24848981
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVitamin D (Vit D) deficiency may be linked to the development of obesity-associated complications such as insulin resistance and type 2 diabetes.24849007
Inflammatory Bowel DiseasesDeregulated Nutrient SensingHere we examined the expression, regulation, and function of SIRT1 in IBD.24850427
Inflammatory Bowel DiseasesDeregulated Nutrient SensingSIRT1 RNA and protein expression was less pronounced in whole biopsies and lamina propria mononuclear cells (LPMCs) of IBD patients in comparison with normal controls.24850427
Inflammatory Bowel Diseases, Tumor necrosisDeregulated Nutrient SensingSIRT1 expression was downregulated in control LPMC by tumor necrosis factor (TNF)-a and interleukin (IL)-21, and upregulated in IBD LPMC by neutralizing TNF-a and IL-21antibodies.24850427
Inflammatory Bowel DiseasesDeregulated Nutrient SensingConsistently, SIRT1 expression was increased in mucosal samples taken from IBD patients successfully treated with Infliximab.24850427
Inflammatory Bowel DiseasesDeregulated Nutrient SensingTreatment of IBD LPMC with Cay10591, a specific SIRT1 activator, reduced NF-kB activation and inhibited inflammatory cytokine synthesis, whereas Ex527, an inhibitor of SIRT1, increased interferon (IFN)-g in control LPMC.24850427
ColitisDeregulated Nutrient SensingSIRT1 was also reduced in mice with colitis induced by 2,4,6-trinitrobenzenesulphonic acid or oxazolone.24850427
Inflammatory Bowel DiseasesDeregulated Nutrient SensingData indicate that SIRT1 is downregulated in IBD patients and colitic mice and suggest that SIRT1 activation can help attenuate inflammatory signals in the gut.24850427
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingConsequently, a greater number suffered from dyslipidaemia, diabetes and hypertension.24852888
Apolipoproteins B, DyslipidemiasDeregulated Nutrient SensingEffects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia.24855368
DyslipidemiasDeregulated Nutrient SensingGreater dissociation of apoB, LDL-C, and non-HDL-C targets occur following treatment with ERN/LRPT, SIMVA, and ERN/LRPT + SIMVA in patients with dyslipidemia.24855368
Colorectal CarcinomaDeregulated Nutrient SensingIn the present study, we found that, in human colorectal cancer cells, low-dose camptothecin (CPT) simultaneously induced autophagy and premature senescence through AMPK-TSC2-mTOR pathway and ATM-Chk2-p53-p21 pathway respectively.24858802
Carotid Atherosclerosis, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney DiseasesDeregulated Nutrient SensingCumulative effects of hypertension, dyslipidemia, and chronic kidney disease on carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus.24860832
Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney DiseasesDeregulated Nutrient SensingThe presence of hypertension, dyslipidemia, and chronic kidney disease (CKD) was documented in 106 Chinese subjects with type 2 diabetes.24860832
Dyslipidemias, Hypertension, CTCAE, Dental Plaque, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney DiseasesDeregulated Nutrient SensingHypertension, dyslipidemia, and CKD in Chinese patients with type 2 diabetes have cumulative effects on the burden of carotid plaque.24860832
Glucose Intolerance (disease), Overweight, ObesityDeregulated Nutrient SensingEighteen patients with overweight or obesity and glucose intolerance were invited to participate in an exercise program consisting in three sessions per week for 3 months.24861112
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBlood pressure, dyslipidaemia and diabetes were controlled in 47.5%, 37.4% and 43.8% of the population who were treated for the respective risk factors, with more than one-fourth of the controlled patients remaining at high risk.24862614
Large prostate, ETV3 wt AlleleDeregulated Nutrient SensingOur results suggest that MetS, BMI, low HDL-C level, increased serum insulin and especially insulin resistance are considered risk factors for prostate enlargement in elderly Chinese men.24862628
Albuminuria, diabeticDeregulated Nutrient SensingTo investigate the associations of 25-(OH)D and b -cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients.24868538
Albuminuria, diabeticDeregulated Nutrient Sensing25-(OH)D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated with b-cell function or insulin resistance.24868538
Prediabetes syndrome, Dyslipidemias, Lupus Erythematosus, SystemicDeregulated Nutrient SensingTaken together, these data suggest that SLE may play an important role in improving blood glucose, insulin resistance, adiposity, and dyslipidemia in prediabetes subjects consuming their habitual diet, similar to or better than BE.24873894
diabeticDeregulated Nutrient SensingVildagliptin compared to glimepiride on post-prandial lipemia and on insulin resistance in type 2 diabetic patients.24874591
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingTPA was also more strongly associated with dyslipidemia and hypertension compared to cIMT.24876099
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingEvaluation of target-directed treatment of dyslipidemia and diabetes mellitus demonstrated suboptimal control, with only 66% and 54% of patients, respectively, achieving the recommended therapeutic targets.24877186
Cardiovascular morbidity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance predicts early cardiovascular morbidity in men without diabetes mellitus, with effect modification by physical activity.24879358
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient Sensingto assess how well insulin resistance predicts cardiovascular disease (CVD) in non-diabetic men and women and to explore the influence of physical activity.24879358
Metabolic Diseases, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingIn men elevated estradiol levels and associated metabolic disorders have been implicated in the development of common diseases including cardiovascular disorders, insulin resistance and type 2 diabetes mellitus, as increased estradiol associated with decreased testosterone levels increases the risk of these diseases.24880967
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDo static and dynamic insulin resistance indices perform similarly in predicting pre-diabetes and type 2 diabetes?24882014
Prediabetes syndrome, Demographics DomainDeregulated Nutrient SensingWe designed a study to compare the predictive power of static and dynamic insulin resistance indices for categorized pre-diabetes (PDM)/type 2 diabetes (DM).24882014
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Chronic disease, Cardiovascular DiseasesDeregulated Nutrient SensingPolyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance.24886552
Colorectal CarcinomaDeregulated Nutrient SensingOverexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer.24890145
Colorectal CarcinomaDeregulated Nutrient SensingHowever, the correlations among SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear.24890145
Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray, including 120 paired colorectal cancer and normal mucosa tissues.24890145
AdenocarcinomaDeregulated Nutrient SensingThere was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissue (P < 0.01, kh(2) test).24890145
Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 may play an important role in the progression of colorectal cancer.24890145
Fatty Liver, DyslipidemiasDeregulated Nutrient SensingNormal circulating lipids, rates of hepatic de novo lipogenesis and appropriate hepatic triglyceride content for degree of adiposity in the patients we describe suggest that even lifelong GCK activation in isolation is insufficient to produce fatty liver and metabolic dyslipidaemia.24890200
Ascites, Toxic effect, Hyperglycemia, Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingThe most common grade 3 to 4 toxicities were hypertension, glucose intolerance, ascites, ALT elevation, hyperglycemia and thrombosis/embolism.24890858
NeoplasmsDeregulated Nutrient SensingAMP-activated protein kinase (AMPK) has a central role in cellular energy sensing and is activated in preclinical tumour models following anti-vascular endothelial growth factor (VEGF) therapy.24892446
Colorectal CarcinomaDeregulated Nutrient SensingPrognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab.24892446
Primary malignant neoplasmDeregulated Nutrient SensingThe possible predictive or prognostic role of AMPK status in cancer patients treated with anti-VEGF drugs has not been investigated so far.24892446
Colorectal CarcinomaDeregulated Nutrient SensingExpression of components of the AMPK pathway including phosphorylated AMPK (pAMPK), phosphorylated acetyl-Coa carboxylase (pACC) and liver kinase B1 (LKB1) was investigated by immunohistochemistry in 48 colorectal cancers treated with FOLFIRI plus bevacizumab.24892446
Colorectal CarcinomaDeregulated Nutrient SensingOur findings suggest that high tissue AMPK activation is a prognostic biomarker in this cohort of metastatic colorectal cancer patients.24892446
Dental Plaque, Data types - Address, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingThese findings suggest that a reduction in plaque burden and mitochondrial dysfunction through the activation of AMPK may be one of the mechanisms by which quercetin improves cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of AD.24893798
Diabetic RetinopathyDeregulated Nutrient SensingSirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.24894401
Diabetic RetinopathyDeregulated Nutrient SensingThe goal of this study is to investigate the role of Sirt1 in the activation of MMP-9 in diabetic retinopathy.24894401
Mitochondrial Damage, HyperglycemiaDeregulated Nutrient SensingThe effect of hyperglycemia and Sirt1 activator, resveratrol, on acetylation of p65 and its binding at MMP-9 promoter-and mitochondrial damage and apoptosis-was assessed in the retinal endothelial cells.24894401
diabeticDeregulated Nutrient SensingRetina from wild-type diabetic mice presented similar decrease in Sirt1, and diabetic mice with Sod2 overexpression or MMP-9 deletion had normal retinal Sirt1.24894401
Diabetic RetinopathyDeregulated Nutrient SensingRetinal microvasculature from human donors with established diabetic retinopathy also had decreased Sirt1.24894401
Diabetes MellitusDeregulated Nutrient SensingThus, in diabetes, increase in oxidative stress inhibits Sirt1 and p65 is hyperacetylated, increasing the binding of p65 at MMP-9 promoter.24894401
Diabetic RetinopathyDeregulated Nutrient SensingPrevention of Sirt1 inhibition, via modulating acetylation of p65, should protect activation of MMP-9 and inhibit the development of diabetic retinopathy.24894401
Diabetes MellitusDeregulated Nutrient SensingAlthough we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance.24895271
Diabetes MellitusDeregulated Nutrient SensingThis relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.24895271
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia was found in 188 (37.2%), diabetes in 101 (20%) and smoking in 36 (7.1%).24897474
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingLow serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance, the metabolic syndrome, and type 2 diabetes.24898240
Diabetes MellitusDeregulated Nutrient SensingBecause many non-Western immigrants in the Netherlands are vitamin D deficient, obese, and at high risk of diabetes, vitamin D supplementation may contribute to prevent diabetes and insulin resistance.24898240
DyslipidemiasDeregulated Nutrient SensingThese findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies.24898282
Coronary ArteriosclerosisDeregulated Nutrient SensingWe have reported that a low serum lipoprotein lipase (LPL) mass level reflects insulin resistance and may be a risk factor for atherosclerotic diseases.24898600
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingTherefore, LPL may represent a link between low adiponectin and dyslipidemia found in metabolic syndrome and type 2 diabetes mellitus.24905278
Diabetes MellitusDeregulated Nutrient SensingAll the aforementioned results resulted from AMPK activation, but a residual activity of metformin after AMPK blockade was still noticeable even after inhibition of AMPK by compound C. Authors believe that metformin-based therapy, a cornerstone in diabetes therapy, not only improves the prognosis of diabetics by reducing blood glucose but also by reducing oxidative stress, inflammatory cytokine production and the shift toward alternative activation of macrophages.24905518
Beta-cell dysfunctionDeregulated Nutrient SensingInsulin resistance and beta-cell dysfunction are involved in the pathogenesis of T2DM.24906975
Non-alcoholic Fatty Liver Disease, Beta-cell dysfunctionDeregulated Nutrient SensingInsulin resistance is associated with NAFLD but little is known about beta-cell dysfunction and NAFLD.24906975
Non-alcoholic Fatty Liver Disease, Beta-cell dysfunctionDeregulated Nutrient SensingThe association of NAFLD severity with beta-cell dysfunction is stronger than that with insulin resistance.24906975
Diabetes MellitusDeregulated Nutrient SensingInsulin requirement varies between patients with diabetes due to insulin resistance.24907169
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAge, sex,diabetes,hypertension, smoking, dyslipidemia and physical activity showed no correlation with lesion in right or circumflex coronary artery.24907949
Blood GlucoseDeregulated Nutrient SensingMagnesium supplements modestly improved fasting glycemia without effect on insulin resistance.24909487
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingRecent studies have determined that branched-chain (BCAAs) and aromatic (AAAs) amino acids are strongly correlated with obesity and atherogenic dyslipidemia and are strong predictors of diabetes.24910999
Endothelial dysfunctionDeregulated Nutrient SensingIt has been established that insulin resistance is frequently associated with endothelial dysfunction.24911636
Acanthosis Nigricans, Muscle Cramp, HypertrophyDeregulated Nutrient SensingSyndrome of insulin resistance with acanthosis nigricans, acral hypertrophy and muscle cramps in an adolescent - a rare diagnosis revisited.24912440
Muscle Cramp, HypertrophyDeregulated Nutrient SensingThe authors report a 14-y-old boy with insulin resistance, acanthosis nigricans, acral hypertrophy and muscle cramps.24912440
Heart failureDeregulated Nutrient SensingThe AMPK-Nampt-Sirt1 axis also showed inhibition in advanced heart failure in addition to severely impaired AMPK activation.24913149
Heart failureDeregulated Nutrient SensingDownregulation of Sirt1 as aging change in advanced heart failure.24913149
Reperfusion InjuryDeregulated Nutrient SensingSirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against ischemia/reperfusion injury in murine heart.24913149
Heart failureDeregulated Nutrient SensingThe role of Sirt1 in heart failure, especially in human hearts is not clear.24913149
Heart failureDeregulated Nutrient SensingThe expression of Sirt1 and other (associated) downstream molecules in human cardiomyocytes from patients with advanced heart failure was examined.24913149
Heart failureDeregulated Nutrient SensingSirt1 was down-regulated (54.92% +- 7.80% in advanced heart failure samples compared with healthy control cardiomyocytes).24913149
Heart failureDeregulated Nutrient SensingIn advanced heart failure, low Sirt1 expression, like aging change may be a significant contributing factor in the downregulation of antioxidants and upregulation of proapoptotic molecules through the p53, FoxO1, and oxidative stress pathways.24913149
Post-Traumatic Stress Disorder, DyslipidemiasDeregulated Nutrient SensingBehavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia.24913341
Post-Traumatic Stress Disorder, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingPosttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease.24913341
Post-Traumatic Stress Disorder, DyslipidemiasDeregulated Nutrient SensingAlthough this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia.24913341
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn fact, metformin may improve insulin resistance, a common finding of PCOS, and reduce insulin blood levels.24913417
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingIn the presence of obesity and glucose intolerance states, particularly if those patients fail to modify their lifestyles, metformin may have some significant benefits.24913417
Hyperglycemia, Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingAt high altitude, increased gGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease.24914715
Primary malignant neoplasm, Malignant neoplasm of endometriumDeregulated Nutrient SensingBecause endometrial cancer is associated with insulin resistance, the authors investigated whether a diabetes-therapeutic metformin dose inhibits cancer cell growth in patients with endometrial cancer.24917306
DrowningDeregulated Nutrient SensingGLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.24917578
Inflammation, Sleep Apnea, Obstructive, Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and obstructive sleep apnea tend to coexist and are associated with inflammation, insulin resistance, dyslipidemia, and high blood pressure, but their causal relation to these abnormalities is unclear.24918371
Weight decreasedDeregulated Nutrient SensingIn secondary analyses, weight loss provided an incremental reduction in insulin resistance and serum triglyceride levels when combined with CPAP.24918371
Burn injuryDeregulated Nutrient SensingPredictors of insulin resistance in pediatric burn injury survivors 24 to 36 months postburn.24918945
Burn injuryDeregulated Nutrient SensingThe purpose of this study was to identify factors associated with long-term insulin resistance in pediatric burn injury survivors.24918945
Burn injuryDeregulated Nutrient SensingBurn size, time postburn, age, lean mass, and adiposity are significant predictors of insulin resistance in pediatric burn injury survivors.24918945
ARCN1 gene, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe most prevalent co-morbidities among respondents with COPD were hypertension (54.5%) and dyslipidaemia (26.5%).24921714
ARCN1 gene, Dyslipidemias, EQ-5D-5L - Anxiety or Depression, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingOur analysis showed that the most prevalent co-morbidities in COPD were hypertension, dyslipidaemia, chronic renal disease and anxiety/depression.24921714
CD55 gene, Obesity, Abdominal, Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingAfter adjusting for potential confounders, we found that greater consumption of soy protein (6.1 vs. 0.5 g/d) was inverse associated with the presence of elevated total cholesterol (TC), dyslipidemia, abdominal obesity and hyperuricemia in women, and with abdominal obesity in men, although no significant sex-soy interactions were observed (P: 0.145-0.985).24925121
Dyslipidemias, HyperuricemiaDeregulated Nutrient SensingGreater soy consumption was associated with a lower presence of elevated TC, dyslipidemia, hyperuricemia and less number of cardiometabolic disturbances components in women.24925121
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingSerum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease.24927647
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (o-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).24927647
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingSerum phospholipid o-3 PUFA levels were significantly decreased in patients with T2DM and NAFLD, and were negatively related with insulin resistance.24927647
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe models were adjusted for age, sex, waist circumference, diabetes mellitus, dyslipidemia, anti-inflammatory medication and month of blood sampling.24928661
Cardiomyopathies, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn this study, we determined the respective effects of obesity, insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial function of the human myocardium before the onset of cardiomyopathy.24928681
Obesity, Diabetes Mellitus, diabetic, Erectile dysfunctionDeregulated Nutrient SensingWorsening of intrinsic myocardial contraction in the transition from obesity to diabetes mellitus is likely related to worsening of cardiac mitochondrial function because impaired mitochondrial function and dynamics and contractile dysfunction are observed in diabetic patients but not in "metabolically healthy" obese patients at early stage in insulin resistance.24928681
ObesityDeregulated Nutrient SensingZinc-Alpha 2-Glycoprotein (ZAG) has recently been implicated in the regulation of adipose tissue metabolism due to its negative association with obesity and insulin resistance.24929893
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrevalence of atherogenic dyslipidemia in primary care patients at moderate-very high risk of cardiovascular disease.24931442
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingAtherogenic dyslipidemia is an important risk factor for cardiovascular disease.24931442
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients had previous cardiovascular disease, diabetes mellitus, SCORE risk >= 3, severe hypertension or dyslipidemia.24931442
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia was defined as low HDL-C (<40 mg/dL [males], <50 mg/dL [females]) and elevated triglycerides (>= 150 mg/dL).24931442
DyslipidemiasDeregulated Nutrient SensingThe overall atherogenic dyslipidemia prevalence was 27.1% (34.1% in diabetics).24931442
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWhen LDL-C levels are controlled, atherogenic dyslipidemia is more prevalent in those patients at highest cardiovascular risk and with diabetes.24931442
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingAlzheimer's disease (AD) is associated with insulin resistance and specific regional declines in cerebral metabolism.24931567
Dyslipidemias, Obesity, PrehypertensionDeregulated Nutrient SensingThere was a difference in baPWV and cfPWV by age group on prehypertension, dyslipidemia, current smoking, or obesity (P<0.001).24932081
DyslipidemiasDeregulated Nutrient SensingRapid relief of dyslipidemia by LDL-A may provide early remission in about half of the NS patients who are resistant to conventional medication.24934117
HyperglycemiaDeregulated Nutrient SensingAsian patients experienced a higher incidence of grade >= 2 hyperglycemia (37.5 vs. 18.1%, p = 0.03), and greater increases in FPG, HgbA1c, and insulin resistance.24934865
Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, hafnium, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingThese patients were significantly older, with higher rates of hypertension, diabetes, clinical CAD, HF, chronic kidney disease, and cancer, and with lower rates of smoking and dyslipidemia than their counterparts (p < .05 for all).24935912
Cancer-related fatigue, Inflammation, Low muscle mass, Obesity, VisceralDeregulated Nutrient SensingPrevious studies have shown that low cardiorespiratory fitness (CRF), visceral obesity and low muscle mass may share pathophysiological mechanisms, such as insulin resistance and chronic inflammation.24937121
Diabetes Mellitus, Non-Insulin-Dependent, Chronic diseaseDeregulated Nutrient SensingType 2 diabetes is a chronic disease characterized by inadequate b-cell response to the progressive insulin resistance.24937531
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingWomen were significantly less likely to have their lipid profiles taken (OR=1.17, 95% CI 1.03-1.33), be prescribed lipid lowering medication for dyslipidemia (OR=1.54, 95% CI 1.20-1.97), and to be prescribed ASA following stroke (OR=1.56, 95% CI 1.39-1.75).24938405
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTwenty-one patients (39%) presented with hypertension, 17 (31%) with dyslipidemia, and 4 (7%) with diabetes.24938637
Familial juvenile gout, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingKidney function progressively deteriorates in patients with familial juvenile hyperuricemiac nephropathy (FJHN, OMIN 162000) and chronic renal disease is commonly associated to dyslipidemia.24940667
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, ObesityDeregulated Nutrient SensingBody mass index, type 2 diabetes, hypertension, dyslipidemia, and obesity were compared.24943389
Neoplasm Metastasis, Malignant Neoplasms, NeoplasmsDeregulated Nutrient SensingNovel (nua) kinase family 1 (NUAK1) is a member of the human adenosine monophosphate-activated protein kinases family, which is overexpressed in multiple human malignancies and thought to be involved in tumor invasion and metastasis ability.24943992
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPositive effects of football on fitness, lipid profile, and insulin resistance in Brazilian patients with type 2 diabetes.24944132
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe evaluated the effects of recreational football training combined with calorie-restricted diet (football + diet) vs calorie-restricted diet alone (diet) on aerobic fitness, lipid profile, and insulin resistance indicators in type 2 diabetes (T2D) patients.24944132
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingCommon genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.24947364
Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingWe aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals.24947364
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWhile the secretion score had a stronger association with T2D in leaner individuals (Pinteraction = 0.001), we saw no difference in the association of the insulin resistance score with T2D among BMI or waist strata (Pinteraction > 0.31).24947364
Cardiovascular DiseasesDeregulated Nutrient SensingIn observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease.24947792
Inflammation, Dyslipidemias, Osteoporosis, Cardiovascular DiseasesDeregulated Nutrient SensingThe presence of common risk factors suggests that there is a relationship between osteoporosis and cardiovascular disease, possibly via dyslipidemia and inflammation.24949440
Bone DensityDeregulated Nutrient SensingSirtuin1 (Sirt1), a player in aging and metabolism, regulates bone mass and inhibits sost expression by deacetylating histone 3 at its promoter.24949665
Dyslipidemias, Loss of facial adipose tissueDeregulated Nutrient SensingTo determine the effect of exercise on chemerin in relation to changes in fat loss, insulin action, and dyslipidemia in older adults.24950152
Post-Traumatic Stress Disorder, Diabetes MellitusDeregulated Nutrient SensingGrowing evidence has linked posttraumatic stress disorder (PTSD) to insulin resistance and type-2 diabetes, but most previous studies were cross-sectional.24950602
Post-Traumatic Stress Disorder, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, PTSD was prospectively associated with a 40% increased risk of new-onset type-2 diabetes which was partially explained by a cluster of metabolic and behavioral risk factors known to influence insulin resistance.24950602
Post-Traumatic Stress DisorderDeregulated Nutrient SensingShared biological or behavioral precursors which occur within families may lead to both PTSD and insulin resistance/diabetes.24950602
Hyperglycemia, Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingAntiretroviral treatment associated hyperglycemia and dyslipidemia among HIV infected patients at Burayu Health Center, Addis Ababa, Ethiopia: a cross-sectional comparative study.24950924
Dyslipidemias, Overweight, Obesity, Diabetes MellitusDeregulated Nutrient SensingA high prevalence of overweight, obesity, diabetes and dyslipidemia has been reported following liver transplantation (LT).24951998
Diabetes MellitusDeregulated Nutrient SensingA low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population.24954334
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThese mixed dyslipidaemia combinations combination with the other risk factors such as arterial hypertension, high fasting glucose level increased all-cause and CVD mortality risk in men and women; while, these mixed dyslipidaemias plus smoking increased all-cause and CVD mortality risk only in men compared to never smokers without these dyslipidaemias (respectively HR = 1.89; HR = 1.92); and these dyslipidaemias plus obesity increased all-cause and CVD mortality risk in women (respectively HR = 2.25; HR = 2.39) and CVD mortality risk in men (HR = 1.72), as compared to responders without obesity and these dyslipidaemias.24955583
DyslipidemiasDeregulated Nutrient SensingFindings in our longitudinal study showed that in men and women mixed dyslipidaemias (HDL cholesterol <1.03 mmol/L plus triglycerides >=1.70 mmol/L) significantly increased the risk for all-cause and CVD mortality (respectively in men HR = 1.30; HR = 1.15, in women HR = 1.83; HR = 2.13).24955583
ObesityDeregulated Nutrient SensingThe 12/15-lipoxygenase pathway (ALOX) is present in adipose tissue (AT) and leads to inflammatory cascades that are causal for the onset of insulin resistance in rodent models of obesity.24955608
ObesityDeregulated Nutrient SensingWe have previously shown that early weaning in rats increases the risk of obesity and insulin resistance at adulthood, and leptin resistance can be a prime factor leading to these changes.24956416
Obesity, Visceral, Hyperglycemia, Hyperphagia, Hyperleucinemia, HypoadiponectinemiaDeregulated Nutrient SensingResveratrol prevented the higher body weight, hyperphagia, visceral obesity, hyperleptinemia, hyperglycemia, insulin resistance, and hypoadiponectinemia at adulthood in animals that were early weaned.24956416
Diabetes MellitusDeregulated Nutrient SensingAbstract Background: Lipoprotein particle sizes and concentrations are characteristically altered in patients with insulin resistance (IR) or type 2 diabetes mellitus (T2DM).24959989
AcneDeregulated Nutrient SensingInsulin resistance in patients with post-adolescent acne.24961925
AcneDeregulated Nutrient SensingWe hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne.24961925
AcneDeregulated Nutrient SensingThis study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne.24961925
Ancriviroc, Fibrosis Assessment, MalnutritionDeregulated Nutrient SensingMalnutrition in the advanced fibrosis stage of chronic hepatitis C (CH-C) impairs interferon (IFN) signaling by inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling.24962339
Nonalcoholic Steatohepatitis, LipolysisDeregulated Nutrient SensingAbdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis.24962805
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingSystemic insulin resistance (IR) is a primary feature in non-alcoholic steatohepatitis (NASH), however, there remain limited data on tissue-specific insulin sensitivity in vivo.24962805
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOf these, 72.3% self-reported having hypertension; 38.4%, dyslipidemia; and 37.8%, diabetes.24964639
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus is characterized by metabolic dysregulation in the form of hyperglycemia and insulin resistance and can have a profound impact on brain structure and vasculature.24967157
Cerebrovascular accidentDeregulated Nutrient SensingRacial differences in the association of insulin resistance with stroke risk: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.24968932
Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance is associated with increased stroke risk, but the effect has not been adequately examined separately in white and black populations.24968932
COL4A2 wt AlleleDeregulated Nutrient SensingAfter adjustment for demographic factors and risk factors, there was a significant difference by race in the association of insulin resistance with risk of ICH (P=0.07), with a decrease in the risk of ICH in whites (HRln(IR)=0.61; 95% CI, 0.35-1.04) but a nonsignificant increase in blacks (HRln(IR)=1.20; 95% CI, 0.60-2.39).24968932
COL4A2 wt Allele, Cerebrovascular accidentDeregulated Nutrient SensingThese data support the growing evidence that insulin resistance may play a more important role in stroke risk among white than black individuals and suggest a potentially discordant relationship of insulin resistance on CI and ICH among whites.24968932
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImpaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance, increased risk of type II diabetes, and cardiovascular pathology.24968966
vinyltriethoxysilane, OsteopeniaDeregulated Nutrient SensingGTx-758 reduced estrogen deficiency side effects of hot flashes, bone loss, and insulin resistance but with a higher incidence of VTEs.24968970
Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent, Blood GlucoseDeregulated Nutrient SensingThe proinflammatory cytokine interleukin (IL)-1b is implicated in the development of insulin resistance and b-cell dysfunction, whereas higher circulating levels of IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor of IL-1b, has been suggested to improve glycemia and b-cell function in patients with type 2 diabetes.24969107
Peripheral Vascular Diseases, Inflammation, Albuminuria, Peripheral NeuropathyDeregulated Nutrient SensingAll underwent 24-hour blood pressure and HR monitoring, and were assessed for markers of inflammation, insulin resistance, albuminuria, presence of peripheral neuropathy and peripheral vascular disease.24969141
Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingDEPTOR expression negatively correlates with mTORC1 activity and tumor progression in colorectal cancer.24969890
Neoplasm Metastasis, Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingThe aim of this study was to investigate the expression of DEPTOR and mTORC1 activity (P-S6) in a subset of CRC patients and determine their relation to tumor differentiation, invasion, nodal metastasis and disease-free survival.24969890
Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingThus, we conclude that expression of DEPTOR negatively correlates with mTORC1 activity and tumor progression in CRC.24969890
Inflammation, GRN wt AlleleDeregulated Nutrient SensingCollectively, our findings suggest that circulating PGRN is significantly associated with systemic insulin sensitivity and autophagic activity in adipose tissue and support the notion that PGRN functions as a potential link between chronic inflammation and insulin resistance.24971611
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, HyperandrogenismDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is mainly defined by hyperandrogenism but is also characterized by insulin resistance (IR).24971613
Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, ChronicDeregulated Nutrient SensingInsulin resistance (IR) affects sustained virological response (SVR) to peginterferon alfa plus ribavirin (PR) in patients with chronic hepatitis C (CHC).24974131
Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunctionDeregulated Nutrient SensingDiabetes appeared associated with classical risk factors for type 2 diabetes (i.e., age, sex, family history of diabetes and body mass index), and both beta-cell dysfunction and insulin resistance appeared relevant determinants.24974302
TG gene, DyslipidemiasDeregulated Nutrient SensingAfter adjustment for age, ethnicity, education, smoking, alcohol consumption, dyslipidaemia and BMI, increases in android fat percentage were significantly associated with total cholesterol, TG and HDL cholesterol in males, and total cholesterol, HDL cholesterol and LDL cholesterol in females.24974911
DyslipidemiasDeregulated Nutrient SensingFurther research should consider sex differences and dyslipidemia.24975752
glucose toleranceDeregulated Nutrient SensingThe development of glucose tolerance disorders in adults involves insulin resistance and impaired insulin secretion.24979613
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThese 105 patients were older and had a higher body mass index, a larger waist circumference, higher fasting blood glucose and triglyceride concentrations and lower low-density lipoprotein cholesterol concentrations than non-diabetic patients; they also had higher rates of hypertension (P=0.001) and dyslipidaemia (P=0.02).24980776
HyperglycemiaDeregulated Nutrient SensingCirculating human epidermal growth factor receptor 2 (HER2) is associated with hyperglycaemia and insulin resistance.24981162
HyperglycemiaDeregulated Nutrient SensingBivariate and multivariate linear regression analyses on the whole study population revealed that the associations between hyperglycemia and HER2, as well as between ISI and HER2, were independent of factors known to be associated with T2DM and insulin resistance (e.g.24981162
HyperglycemiaDeregulated Nutrient SensingThere is an independent association between HER2 levels and hyperglycemia and insulin resistance that is not modified by country of birth.24981162
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingLeptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients.24981337
Dyslipidemias, Diabetes Mellitus, cardiovascular problem, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingThe objective is to determine the presence of peripheral arterial disease (PAD) and the factors associated in elderly patients, analyzing variables such as sex, age, smoking, diabetes, hypertension, dyslipidemia, and cardiovascular problems.24984302
Impaired T cell functionDeregulated Nutrient SensingPrediabetes is an early stage of b-cell dysfunction presenting as insulin resistance.24985580
Refractory anemias, Rheumatoid ArthritisDeregulated Nutrient SensingIn prior reports, individuals with rheumatoid arthritis (RA) exhibited increased insulin resistance.24986846
Renal glomerular diseaseDeregulated Nutrient SensingHere, we demonstrated that mammalian target of rapamycin complex 1 (mTORC1) signaling was remarkably activated and hypoxia-inducible factor (HIF) 1a expression was largely induced in cellular crescents from patients with crescentic glomerular diseases.24990893
Abnormal renal functionDeregulated Nutrient SensingSpecific deletion of Tsc1 in podocytes led to mTORC1 activation in podocytes and kidney dysfunction in mice.24990893
Renal glomerular diseaseDeregulated Nutrient SensingTogether, it is concluded that mTORC1 activation in podocytes promotes cellular crescent formation, and targeting this signaling may shed new light on the treatment of patients with crescentic glomerular diseases.24990893
Chronic Obstructive Airway Disease, Dyslipidemias, Carcinoma of lung, Cerebrovascular accidentDeregulated Nutrient SensingAge, male sex, and chronic obstructive pulmonary disease were positively; but dyslipidemia, stroke and higher socioeconomic status were negatively associated with lung cancer.24991802
Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingType 2 diabetes is often accompanied by altered cardiometabolic risk profiles, including abdominal obesity, hypertension, and dyslipidaemia.24992024
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingAgeing and type 2 diabetes in an elderly Chinese population: the role of insulin resistance and beta cell dysfunction.24992623
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIndividuals with NGT or prediabetes who progressed to T2D during follow-up had a significantly increased insulin resistance and a decreased beta cell function (p < 0.01).24992623
Prediabetes syndromeDeregulated Nutrient SensingIn contrast, individuals who regressed from prediabetes to NGT increased both insulin resistance and beta cell function (p < 0.01).24992623
Microalbuminuria, InflammationDeregulated Nutrient SensingAssociation of urinary RBP4 with insulin resistance, inflammation, and microalbuminuria.24994759
Microalbuminuria, InflammationDeregulated Nutrient SensingUrinary RBP4 concentrations were elevated in patients with dysregulation of glucose metabolism and were related to various cardiometabolic risk factors including insulin resistance, inflammation, and microalbuminuria.24994759
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingComparison of the efficacy and safety profile of morning administration of controlled-release simvastatin versus evening administration of immediate-release simvastatin in chronic kidney disease patients with dyslipidemia.24996489
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingMorning administration of CR simvastatin is expected to increase patient compliance and therefore better control of dyslipidemia in CKD patients.24996489
ObesityDeregulated Nutrient SensingDecreased omentin-1 levels may contribute to the development of insulin resistance, T2DM and particularly to obesity in Chinese adults, however, its role in these diseases needs to be fully elucidated.24997770
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEvidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear.24998955
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe high percentage of obesity, hypertension and dyslipidaemia among them are important co morbidity factors which if not controlled can cause further increase in the number of chronic complications.24999139
Metabolic Diseases, Primary malignant neoplasmDeregulated Nutrient SensingStructure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders.25000096
Primary malignant neoplasm, Diabetes Mellitus, Non-Insulin-Dependent, Disease, ObesityDeregulated Nutrient SensingSirtuin 1(SIRT1), a NAD(+) dependent class III histone deacetylase is involved in a variety of human disorders such as obesity, type II diabetes, cancer and aging.25000096
Metabolic Diseases, Primary malignant neoplasmDeregulated Nutrient SensingInhibition of SIRT1 could be useful for cancer treatment while activators can be useful for longevity and treating metabolic disorders.25000096
Primary malignant neoplasmDeregulated Nutrient SensingIn this paper, we report diverse small molecule inhibitors with a potential to attenuate cancer growth designed based on high-throughput virtual screening and docking using the crystal structure of SIRT1.25000096
Diabetes MellitusDeregulated Nutrient SensingRecent animal studies indicated that VEGF-B signaling had determinant roles in insulin resistance, lipid distribution and metabolism in type 2 diabetes.25001655
Diabetes MellitusDeregulated Nutrient SensingThis mechanism can contribute to the development of insulin resistance and diabetes associated with immunosuppressive therapy.25004245
Refractory anemias, Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingOur aim was to describe the prevalence of dyslipidaemia, serum lipid behaviour and predictors of serum lipid levels in a cohort of early rheumatoid arthritis (RA) patients.25005131
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidaemia in early RA patients differed from the matched controls.25005131
Glucose Intolerance (disease), Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingIn these enrolled subjects, 88% have glucose intolerance status (pre-diabetes or diabetes).25007953
Glucose Intolerance (disease), Memory impairmentDeregulated Nutrient SensingHigh-fat diet enhanced glucose intolerance, brain soluble Ab, and memory impairment in 3xTg-AD mice.25008180
Obesity, AbdominalDeregulated Nutrient SensingPartly replacing meat protein with soy protein alters insulin resistance and blood lipids in postmenopausal women with abdominal obesity.25008579
Hypertriglyceridemia, Dyslipidemias, Obesity, Acanthosis Nigricans, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence rates of hypertension, dyslipidemia, hypertriglyceridemia, and acanthosis nigricans in severe obese children were higher than those in moderate obesity.25009022
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients suffering from type 2 diabetes mellitus (T2DM) often exhibit chronic elevated lactate levels which can promote peripheral insulin resistance by disturbing skeletal muscle insulin-signaling.25009968
glycation, Prediabetes syndromeDeregulated Nutrient SensingEffect of dietary prebiotic supplementation on advanced glycation, insulin resistance and inflammatory biomarkers in adults with pre-diabetes: a study protocol for a double-blind placebo-controlled randomised crossover clinical trial.25011647
InflammationDeregulated Nutrient SensingAGEs are thought to stimulate chronic low-grade inflammation and promote oxidative stress and have been linked to the development of insulin resistance.25011647
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSimple therapeutic strategies targeted at attenuating the progression of chronic low-grade inflammation and insulin resistance are urgently required to prevent or slow the development of type 2 diabetes in susceptible individuals.25011647
Obesity, Diabetes MellitusDeregulated Nutrient SensingThe presence of large subcutaneous adipocytes in obesity has been proposed to be linked with insulin resistance and type 2 diabetes through the "adipose tissue expandability" hypothesis, which holds that large adipocytes have a limited capacity for expansion, forcing lipids to be stored in nonadipose ectopic depots (skeletal muscle, liver), where they interfere with insulin signaling.25011943
Alarmins, diabeticDeregulated Nutrient SensingAccumulation of damp heat in spleen type accounts for the highest proportion in type 2 diabetic patients, and there exists serious insulin resistance.25016266
Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingArterial location-specific calcification at the carotid artery and aortic arch for chronic kidney disease, diabetes mellitus, hypertension, and dyslipidemia.25017195
Chronic Kidney Diseases, Dyslipidemias, Demographics Domain, Hypertension, CTCAEDeregulated Nutrient SensingThe multivariate analyses were adjusted for age, gender, CKD, DM, hypertension, dyslipidemia, and current smoking status.25017195
Dyslipidemias, CalcinosisDeregulated Nutrient SensingDyslipidemia did not have any significant association with calcification in any of the three vascular beds.25017195
Metabolic DiseasesDeregulated Nutrient SensingThe results confirmed that insulin resistance is present in many obese children and adolescents, and that this condition is associated with alterations that represent an increased risk for developing metabolic disorders in adulthood.25019650
Stomach CarcinomaDeregulated Nutrient SensingTo evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.25024613
Weight GainDeregulated Nutrient SensingIn adults, insulin resistance may decrease the thermogenic effect of food, contributing to weight gain.25026915
ObesityDeregulated Nutrient SensingWe aimed to determine the effect of insulin resistance on energy expenditure in children with long-standing obesity.25026915
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing20% of patients with hypertension, 41% with dyslipidemia and 36% with diabetes mellitus were in control at baseline.25027581
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOver 12 months, therapy of 61% of patients with baseline poor control was modified for hypertension, 33% for dyslipidemia, and 85% for diabetes mellitus.25027581
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe found low rates of potential overtreatment with 2% for hypertension, 3% for diabetes mellitus and 3-6% for dyslipidemia.25027581
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDPP4 activity is an important predictor of the onset of insulin resistance, prediabetes, and type 2 diabetes in apparently healthy Chinese individuals.25029421
Cardiac Arrest, Hyperglycemia, Hypothermia due to exposureDeregulated Nutrient SensingHyperglycemia and insulin resistance in cardiac arrest patients treated with moderate hypothermia.25033067
Hypothermia due to exposureDeregulated Nutrient SensingBG, insulin infusion rates, and insulin resistance during hypothermia, during rewarming, and 24-48 hours after hypothermia were not significantly different between the 2 groups.25033067
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known.25034241
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear.25034241
TG gene, DyslipidemiasDeregulated Nutrient SensingIn Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.25034241
Hypertension, CTCAE, Dyslipidemias, Respiration DisordersDeregulated Nutrient SensingThe most frequent co-morbidities were: hypertension (30.0%), dyslipidemia (23.3%) and respiratory disease (25.2%).25034320
Obesity, Abdominal, Polycystic Ovary SyndromeDeregulated Nutrient SensingCentral arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk.25035436
Prostate Cancer Outcomes Study, Cardiovascular Physiological Phenomena, ObesityDeregulated Nutrient SensingInsulin resistance and central obesity are associated with subclinical cardiovascular dysfunction in young women, but a diagnosis of PCOS does not appear to confer additional risk at this age.25035436
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingHowever, it is difficult to establish how much of this risk is due to PCOS per se and how much is due to obesity and insulin resistance, which are common in PCOS and themselves associated with greater vascular risk.25035436
Arterial Stiffness, Prostate Cancer Outcomes Study, Diastolic dysfunction, ObesityDeregulated Nutrient SensingThis study shows that central arterial stiffness and diastolic dysfunction are not increased in young women with PCOS, whereas they are associated with both insulin resistance and central obesity.25035436
Neoplasm Metastasis, NeoplasmsDeregulated Nutrient SensingIn this study, we report the impact of the investigational drug PP242, a potent and selective small-molecule active-site TORC1/2 kinase inhibitor, on tumor growth and metastasis.25035961
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis observed dysregulation in energy-related metabolism may be the underlying factor leading to the molecular mechanisms responsible for the insulin resistance of patients with T2D.25036354
atheroscleroticDeregulated Nutrient SensingIn this study, we observed an inverse correlation between SIRT1, a class III histone deacetylase, and PAI-1 expression in human atherosclerotic plaques and the aortas of old mice, suggesting that internal negative regulation exists between SIRT1 and PAI-1.25040736
Arterial StiffnessDeregulated Nutrient SensingSIRT1 overexpression reversed the increased PAI-1 expression in senescent human umbilical vein endothelial cells (HUVECs) and aortas of old mice, accompanied by decreased SA-b-gal activity in vitro and improved endothelial function and reduced arterial stiffness in vivo.25040736
Old ageDeregulated Nutrient SensingMoreover, the SIRT1-mediated inhibition of PAI-1 expression exerted an antisenescence effect in HUVECs.25040736
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAmino acid (AA) metabolism is altered in type 2 diabetes (T2D), and fasting levels of a-hydroxybutyrate (a-HB), a biomarker for insulin resistance, have been suggested to track AA metabolism.25040945
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingCompared to N-pre group, the pre-group had a significantly higher rate of smoking [56.4% (79/140) vs. 44.4% (92/207), P < 0.05], dyslipidemia [61.4% (86/140) vs. 50.2% (104/207), P < 0.05] and positive family history of coronary artery disease [39.3% (55/140) vs. 24.6% (51/207), P < 0.01].25042917
Coronary Stenosis, Dyslipidemias, Smoking, Immature, Coronary Artery Disease, Heart failureDeregulated Nutrient SensingSmoking, dyslipidemia and family history of coronary artery disease are major risk factors for patients with premature ACS, these patients are more likely to have milder coronary artery stenosis and a lower incidence of heart failure compared to N-pre group.25042917
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingInsulin resistance (IR) increases Alzheimer's disease (AD) risk.25043908
HyperglycemiaDeregulated Nutrient SensingIn participants with normoglycemia but not hyperglycemia, higher insulin resistance corresponded to higher PiB uptake in frontal and temporal areas, reflecting increased amyloid deposition.25043908
Data types - AddressDeregulated Nutrient SensingThis is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD.25043908
HD Term Type, Cardiac complication, DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia accelerates the development of cardiovascular complications and contributes to mortality of hemodialysis (HD) patients.25044013
HD Term Type, DyslipidemiasDeregulated Nutrient SensingLifestyle changes have selective efficacy in the treatment of dyslipidemia in HD patients, while atorvastatin (up to 20 mg/d) may be effective in about 60% of nonresponders to lifestyle changes.25044013
Heat-Shock ResponseDeregulated Nutrient SensingRecent studies suggest that diethylhexyl phthalates (DEHP) could contribute to the development of insulin resistance (IR) through oxidative stress, and that heat shock protein (HSP) could be related with the association between DEHP and IR.25044062
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImprovement in vitamin D status does not improve insulin resistance, blood pressure, inflammation or HbA1c, but might increase insulin secretion in patients with established type 2 diabetes.25044176
Microalbuminuria, Arterial Stiffness, Endothelial dysfunctionDeregulated Nutrient SensingMicroalbuminuria is a marker of generalized endothelial dysfunction resulting from arterial stiffness or insulin resistance, and brachial-ankle pulse wave velocity (baPWV) is a good measure of arterial stiffness.25045226
MicroalbuminuriaDeregulated Nutrient SensingElevated baPWV was independently associated with microalbuminuria regardless of insulin resistance among rural subjects over 40 yr.25045226
Impaired T cell function, ObesityDeregulated Nutrient SensingPlasma free fatty acids do not provide the link between obesity and insulin resistance or b-cell dysfunction: results of the Reading, Imperial, Surrey, Cambridge, Kings (RISCK) study.25047698
Impaired T cell functionDeregulated Nutrient SensingIt is unlikely that plasma free fatty acids are the primary mediators of obesity-related insulin resistance or b-cell dysfunction.25047698
Degenerative polyarthritis, Cartilage damageDeregulated Nutrient SensingPGC-1a and FoxO3A limit oxidative stress and at least partially mediate the capacity of AMPK activity to block procatabolic responses in chondrocytes, and therefore have the potential to inhibit the progression of cartilage damage in OA.25047750
Thrombosis, Prediabetes syndromeDeregulated Nutrient SensingIn pre-diabetes disorders in which pathogenesis the insulin resistance (IR) plays a leading role, the risk of thrombosis due to increased coagulation factors, decreased concentration of physiological anticoagulants and inhibition of fibrinolysis is increased.25051771
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingPatient vascular risk factors included smoking, dyslipidemia, and hypertension.25051964
DyslipidemiasDeregulated Nutrient SensingIncreased serum uric acid (SUA) is associated with dyslipidemia.25052552
Polycystic Ovary SyndromeDeregulated Nutrient SensingDiverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome.25053727
AtherosclerosisDeregulated Nutrient SensingTo investigate the role of increased intrahepatic fat in the association of SCH with insulin resistance, MS, and coronary atherosclerosis.25053728
SLC25A20 geneDeregulated Nutrient SensingSCH with FL is associated with increased odds of MS, insulin resistance, and CAC, independent of potential confounders.25053728
Inflammation, Breast CarcinomaDeregulated Nutrient SensingInsulin resistance and inflammation may mediate the effects of central adiposity on mortality among breast cancer patients.25056184
Napping, Diabetes MellitusDeregulated Nutrient SensingAssociation of napping and night-time sleep with impaired glucose regulation, insulin resistance and glycated haemoglobin in Chinese middle-aged adults with no diabetes: a cross-sectional study.25056969
DyslipidemiasDeregulated Nutrient SensingStudies have indicated that patients may experience persistent dyslipidemia despite chronic statin treatment.25060204
TG gene, DyslipidemiasDeregulated Nutrient SensingPatient characteristics and lipid measurements were used to determine variables contributing to dyslipidemia (abnormal low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], or total triglyceride [TG] values).25060204
Impaired cognitionDeregulated Nutrient SensingThe relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment.25060738
Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingInsulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome.25060738
Diabetic Nephropathy, Ischemic stroke, Metabolic Syndrome X, Diabetes MellitusDeregulated Nutrient SensingIndependent risk factors for ischemic stroke were duration of diabetes mellitus, presence of diabetic nephropathy, higher hemoglobin A1c, higher systolic blood pressure, insulin resistance, and history of smoking, whereas sex, lipids, high-sensitivity C-reactive protein, and the metabolic syndrome were not associated with an increased risk.25061078
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients in the CAD group were significantly older (41.59 +- 3.79 versus 39.27 +- 4.97 years; P-value < 0.01), and had higher rates of diabetes mellitus (P-value = 0.04) and dyslipidemia (P-value = 0.01).25065277
Stomach CarcinomaDeregulated Nutrient SensingOur findings suggest that Japanese population with higher insulin and C-peptide levels derived from insulin resistance have an elevated risk of gastric cancer.25066446
Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingHistory of dyslipidemia had in 73.3% of patients, 27.8% had cardiovascular disease and 82.7% had hypertension.25066820
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPrevention of this complication with active therapy for risk factors, such as hypertension and dyslipidemia is warranted.25066820
Diabetes MellitusDeregulated Nutrient SensingVitamin D deficiency is a common condition that is associated with diabetes and insulin resistance.25072652
ARCN1 gene, Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus, Asthma, Hypertension, CTCAEDeregulated Nutrient SensingPrevalence: dyslipidemias (34.8); arterial hypertension (17.8); Diabetes (5.3); asthma (4.6); COPD (2.2); ischaemic heart disease (1.8) and (1.5) cardio-circulatory pathologies.25072788
Diabetes Mellitus, Bipolar DisorderDeregulated Nutrient SensingInsulin resistance, diabetes mellitus, and brain structure in bipolar disorders.25074491
Albuminuria, Dyslipidemias, Obesity, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingHypertension was frequent in all CKD stages (80%-94%), whereas there was a lower prevalence of dyslipidemia, albuminuria, and obesity associated with more advanced CKD.25074838
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia in chronic kidney disease: randomized controlled trial of colestilan versus simvastatin in dialysis patients.25079861
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with the new generation of antipsychotic drugs compared to conventional therapy.25082252
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingTo investigate the incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with antipsychotics of new generation compared to conventional therapy.25082252
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingDyslipidemia in the form of hypertriglyceridemia occurs more frequently in patients on therapy with the new generation of antipsychotics compared to patients treated with conventional therapy.25082252
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingHypercholesterolemia as a form of dyslipidemia had not been proven as significantly frequent during the therapy with new antipsychotics in relation to classical antipsychotic treatment.25082252
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe clinical manifestations and the sequelae of PCOS vary throughout the lifecycle, partly depending on environmental factors which may affect the integral components of the syndrome, namely ovarian steroidogenesis, ovulation and insulin resistance.25083888
Hyperlipidemia, Primary malignant neoplasm, InflammationDeregulated Nutrient SensingSince hyperlipidemia, inflammation, insulin resistance and obesity increase breast cancer risk, elevating GH may serve to exacerbate cancer progression.25085903
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingIn China, even though the prevalence of dyslipidemia among adults increased yearly and dyslipidemia being an important risk factor for cardiovascular diseases among the Chinese population, however, the awareness, treatment and control of dyslipidemia are at low levels, and only limited studies on the influence factors associated with the awareness, treatment and control dyslipidemia in China have been carried out.25086650
DyslipidemiasDeregulated Nutrient SensingIncrease in age and BMI >= 24 kg/m2 were by far the strongest risk factors associated with better awareness and treatment of dyslipidemia.25086650
DyslipidemiasDeregulated Nutrient SensingA family history of dyslipidemia increased the likelihood of awareness (OR=3.620; 95% CI: 2.816, 4.653) and treatment (OR=3.298; 95% CI: 2.488, 4.371) of dyslipidemia.25086650
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPromotion of healthy lifestyles and establishment of a comprehensive strategy of screening, treatment and control of dyslipidemia is needed to reduce or prevent the risk of cardiovascular disease in the Jilin province.25086650
Coronary Artery Disease, Ventricular Dysfunction, LeftDeregulated Nutrient SensingEpicardial adipose tissue and insulin resistance in patients with coronary artery disease with or without left ventricular dysfunction.25087293
Systolic dysfunctionDeregulated Nutrient SensingAim of this study was to evaluate the ability of insulin resistance to predict EAT thickness in patients with significant CAD and systolic dysfunction.25087293
Eating, Ventricular Dysfunction, LeftDeregulated Nutrient SensingPotassium levels and all three indexes of insulin resistance were the best independent predictors of EAT in the study population as a whole and in the subset of patients with left ventricular dysfunction.25087293
Ventricular DysfunctionDeregulated Nutrient SensingInsulin resistance is an independent predictor of EAT thickness in patients affected by CAD, also in the presence of significant left ventricular dysfunction.25087293
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingThe association between dyslipidemia (DL) and stroke recurrence is unclear, but may be influenced by different subtypes of stroke.25088494
ObesityDeregulated Nutrient SensingIntrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults.25091356
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn 73.1%, at least 1 cardiovascular risk factor was identified: smoking (40.5%), obesity (26.0%), dyslipidemia (24.8%), hypertension (24.3%), and diabetes mellitus (12.3%).25091923
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingAfter multivariate adjustment robust associations with coronary heart disease, myocardial infarction and dyslipidemia remained.25093413
Prostate Cancer Outcomes Study, Obesity, Abdominal, Polycystic Ovary Syndrome, HyperandrogenismDeregulated Nutrient SensingInsulin resistance associated with abdominal obesity plays a leading role in the etiology of hyperandrogenism and other clinical features of the polycystic ovary syndrome (PCOS).25093427
Hyperglycemia, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingOppositely, fasting insulin (OR 1.03, P < 0.001), hyperglycemia (OR 1.25, P = 0.002) and dyslipidemia (OR 1.25, P = 0.002), but not hypertension, BMI and WC, significantly increased the risk of mildly reduced eGFR.25099525
Diabetic Nephropathy, DyslipidemiasDeregulated Nutrient SensingThe SCH group had a higher prevalence of dyslipidemia (p = 0.008) and diabetic nephropathy (p = 0.014) than the euthyroid group.25100149
Toxic effectDeregulated Nutrient SensingMoreover, decreased insulin/IGF-1 signaling promotes the maintenance of protein quality control and suppresses the onset of cellular toxicity caused by aggregate-prone proteins.25102325
Toxic effectDeregulated Nutrient SensingThus, partial genetic manipulation of the insulin/IGF-1 signaling pathway does not seem sufficient to counteract protein toxicity and extend animal survival.25102325
ObesityDeregulated Nutrient SensingObesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology.25105135
TNF protein, human, Inflammation, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe present studies have demonstrated an independent association of higher PP with higher TNF-a, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension.25105150
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingA high prevalence of obesity (59.9%), type 2 diabetes mellitus (25%), high blood pressure (47.2%), and dyslipidemia (44.4%) was found in the total sample, with no difference between the study groups.25106709
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingOur results confirm the high prevalence of obesity, type 2 diabetes mellitus, high blood pressure, and dyslipidemia in patients with asymptomatic PHP.25106709
DyslipidemiasDeregulated Nutrient SensingTo assess the influence of dyslipidemia on urinary lithogenic metabolites and stone recurrence in stone formers.25106943
Tauopathies, Data types - AddressDeregulated Nutrient SensingThese results provide confirmation and specificity that abnormal phosphorylation of IRS1 is a pathological feature of AD and other tauopathies, and provide support for an association between insulin resistance and abnormal tau as well as amyloid-b.25107476
Vascular calcification, AtherosclerosisDeregulated Nutrient SensingThe relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: the Multi-Ethnic Study of Atherosclerosis.25108074
Obesity, Abdominal, Vascular calcificationDeregulated Nutrient SensingInsulin resistance may be related to vascular calcification as both are associated with abdominal obesity.25108074
atheroscleroticDeregulated Nutrient SensingAtherosclerotic calcification, especially in the coronary arteries, is related to insulin resistance.25108074
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn contrast, risk for established (baseline) diabetes mellitus was lower (OR=0.49, 95% Cl 0.26-0.93, p=0.03) in heterozygotes, after adjustment for atherogenic dyslipidemia and other confounders.25108206
TG gene, Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingObese T2D patients with high TG:HDL, associated with increased insulin resistance, had considerably increased risk of CHD and CVD.25108897
Glucose Intolerance (disease)Deregulated Nutrient SensingWe could not observe the increase rate of glucose intolerance in statin group.25109606
Dyslipidemias, Metabolic Syndrome X, MS gene, ObesityDeregulated Nutrient SensingDyslipidaemia and central obesity are the major factors underlying the dramatic increase in metabolic syndrome (MS).25109606
Prediabetes syndrome, DyslipidemiasDeregulated Nutrient SensingEarly statin treatment can be an effective option in obese patients with MS, prediabetes and mild dyslipidaemia with further improvement of cardiovascular risk factors.25109606
HypertriglyceridemiaDeregulated Nutrient SensingThe hypertriglyceridemia is associated with isolated impaired glucose tolerance in subjects without insulin resistance.25111858
HypertriglyceridemiaDeregulated Nutrient SensingThe objective of this study was to determine if hypertriglyceridemia is associated with isolated impaired glucose tolerance in subjects without insulin resistance.25111858
HypertriglyceridemiaDeregulated Nutrient SensingResults of this study indicate that hypertriglyceridemia is independently associated with isolated impaired glucose tolerance in subjects without insulin resistance.25111858
DyslipidemiasDeregulated Nutrient SensingAmplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose.25112663
Arterial Stiffness, Hyperglycemia, Dyslipidemias, ObesityDeregulated Nutrient SensingNotably, obesity is a modifiable determinant of arterial stiffness independent of high blood pressure, dyslipidemia and hyperglycemia in this population.25112799
Increased insulin level, HyperuricemiaDeregulated Nutrient SensingInsulin resistance itself or compensatory hyperinsulinemia may contribute to the development of hyperuricemia.25112919
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHigher body mass index and waist circumference, hypertension, dyslipidemia, and current smoking were each associated with higher prevalence of diabetes in both men and women.25112921
Diabetes MellitusDeregulated Nutrient SensingThe microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study.25117473
Sense of Inadequacy ScaleDeregulated Nutrient SensingInadequacy was observed in 11, 9, 3 and 4% in relation to insulin resistance, fasting insulin, blood pressure and glycemia, respectively.25119752
SteatohepatitisDeregulated Nutrient SensingHepatic steatosis was found in 20% of the patients and insulin resistance, in 29%.25119755
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels.25120083
Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipidemia and disturbed liver function.25120819
DyslipidemiasDeregulated Nutrient SensingLipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia.25121984
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingTherefore, there is a need to identify novel early markers of glucose intolerance that reflect the underlying biology and the overall physiological, metabolic and clinical characteristics of progression towards diabetes.25125339
Weight Gain, Bipolar DisorderDeregulated Nutrient SensingWeight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder.25130211
Hyperinsulinism, Impaired T cell functionDeregulated Nutrient SensingHyperinsulinaemia, insulin resistance and b-cell dysfunction were not related to the incidence of isolated impaired glucose tolerance in either gender.25131451
Dyslipidemias, OsteopeniaDeregulated Nutrient SensingOur findings suggest that in elderly male patients with osteopenia and mild dyslipidemia, therapeutic doses of atorvastatin were associated with positive effects on BMD, probably mediated by suppressed bone resorption.25131773
Weight Gain, Diabetes Mellitus, Insulin-Dependent, ObesityDeregulated Nutrient SensingWith increasing obesity in childhood and adolescence, weight gain, and insulin resistance become also more frequent in patients with type 1 diabetes mellitus (T1DM).25131985
Breast CarcinomaDeregulated Nutrient SensingThe effect of insulin resistance on breast cancer risk in Latinas of Mexican origin.25136964
Prediabetes syndrome, Breast Carcinoma, Diabetes MellitusDeregulated Nutrient SensingWe determined the effect of insulin resistance (IR) on breast cancer risk in Latinas of Mexican origin who did not have a direct family history of breast cancer and had not been previously diagnosed with prediabetes or diabetes.25136964
ObesityDeregulated Nutrient SensingObesity and insulin resistance are associated with an increase of cardiovascular risk factors, including adipocytokines.25137262
UremiaDeregulated Nutrient SensingInsulin resistance is commonly observed in uremic patients.25137874
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingHigh nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.25139823
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingWe investigated tumor expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in relation with patient survival and tumor relapse in a retrospective cohort of 460 breast cancer patients.25139823
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingImmunohistochemical staining for LSD1, HDAC2 and SIRT1 was performed on tissue microarrays of tumor and corresponding normal formalin-fixed paraffin-embedded tissues from breast cancer patients.25139823
NeoplasmsDeregulated Nutrient SensingExpression of LSD1 and SIRT1, but not of HDAC2, was significantly increased in tumor tissues compared to their normal counterparts (both p < 0.001).25139823
NeoplasmsDeregulated Nutrient SensingWhen the combined expression levels were analyzed, high expression of LSD1, HDAC2 and SIRT1 showed shorter patient survival time and shorter time to tumor relapse and correlated with poor tumor differentiation and a high level of tumor cell proliferation.25139823
Skeletal muscle structureDeregulated Nutrient SensingThe disposition index emphasizes the importance of taking into account both skeletal muscle and hepatic insulin resistance to depict insulin secretion.25139885
Hypertension, CTCAE, Obesity, AtherosclerosisDeregulated Nutrient SensingRecent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis.25142635
Non-Small Cell Lung Carcinoma, NeoplasmsDeregulated Nutrient SensingSIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.25143434
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingIn addition, SIRT1 silencing suppresses non-small cell lung cancer (NSCLC) proliferation and induces senescence in a p27(Kip1)-dependent manner.25143434
Non-Small Cell Lung Carcinoma, NeoplasmsDeregulated Nutrient SensingFurthermore, SIRT1 silencing dramatically suppresses tumor formation and proliferation in two distinct NSCLC xenograft mouse models.25143434
Carcinoma of lungDeregulated Nutrient SensingCollectively, these data demonstrate that not only SIRT1 is an important regulator of p27(Kip1) but also SIRT inhibition induces senescence and antigrowth potential in lung cancer in vivo.25143434
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingSIRT1 is a key regulator of p27 protein levels and SIRT1 inhibition is a viable strategy for NSCLC therapy by means of p27 reactivation.25143434
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular disease (CVD) is related to insulin resistance (IR) and obesity, characterized by changes in plasma levels of inflammatory markers, such as adiponectin and C-reactive protein (CRP).25145771
Stomach CarcinomaDeregulated Nutrient SensingSIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer.25146318
Malignant NeoplasmsDeregulated Nutrient SensingExpression of SIRT1, a class III HDAC, is related to poor prognosis in some malignancies.25146318
Malignant neoplasm of stomachDeregulated Nutrient SensingWe investigated the correlation between SIRT1 expression and progression and prognosis of gastric cancers comparing with molecules linked to SIRT1 in order to better predict the efficacy of HDAC inhibitors in treating this disease.25146318
Stomach CarcinomaDeregulated Nutrient SensingWe evaluated SIRT1 expression by western blot in 51 cases and SIRT1, DBC1, acetylated H4K16 (H4K16Ac), acetylated H3K9 (H3K9Ac), and p53 by immunohistochemistry (IHC) in 557 cases of gastric cancer.25146318
Neoplasms, Venous InvasionDeregulated Nutrient SensingWestern blotting showed that SIRT1 high expression related with statistics to advanced tumor progression, positive lymphatic invasion, positive venous invasion, and advanced stage but not to poor prognosis.25146318
Stomach CarcinomaDeregulated Nutrient SensingWe found that SIRT1 high expression closely correlates with progression and prognosis in gastric cancer patients.25146318
Stomach CarcinomaDeregulated Nutrient SensingAnd it was also indicated that SIRT1 acts as an oncogene by the results of DBC1, H4K16Ac, and H3K9Ac and might be a target molecule of HDAC inhibitor treatment for gastric cancer patients.25146318
Hyperamylasemia, ObesityDeregulated Nutrient SensingAmylin deposition is promoted by chronic hypersecretion of amylin (hyperamylinemia), which is common in humans with obesity or pre-diabetic insulin resistance.25149184
Dyslipidemias, Toxic effect, Genus ErwiniaDeregulated Nutrient SensingThe toxicity of very prolonged courses of PEGasparaginase or Erwinia asparaginase in relation to asparaginase activity, with a special focus on dyslipidemia.25150254
Dyslipidemias, Genus ErwiniaDeregulated Nutrient SensingIn patients receiving Erwinia asparaginase, triglyceride levels increased in the first weeks as well, but no grade 3/4 dyslipidemia was found.25150254
Dyslipidemias, Toxic effectDeregulated Nutrient SensingDyslipidemia was the only toxicity related to levels of asparaginase activity.25150254
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAmong middle-aged and older Japanese adults, sleep-related intermittent hypoxemia is associated with glucose intolerance and insulin resistance, and may contribute to the development of type 2 diabetes mellitus.25156748
Glucose Intolerance (disease)Deregulated Nutrient SensingSleep-related intermittent hypoxemia and glucose intolerance: a community-based study.25156748
Lipodystrophy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D).25157153
Dyslipidemias, Myocardial Ischemia, Congestive heart failure, Hypertensive disease, Hypertension, CTCAEDeregulated Nutrient Sensing86% suffered from hypertension (HTN), 40% were diabetics and ~ 1/3 had ischemic heart disease, congestive heart failure (CHF), and dyslipidemia.25161116
DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia and pathoglycemia were standardized to the WHO world standard population.25164228
DyslipidemiasDeregulated Nutrient Sensing(1) The age adjusted mean average levels of blood lipid and glucose and the standardized prevalence rate of dyslipidemia and increased blood glucose as well as cardiovascular risk factors were significantly higher in the urban than in the rural residents and higher in male than in female participants (P < 0.01 or 0.05).25164228
Weight decreased, Osage language, Dyslipidemias, Diabetes Mellitus, Hypertensive disease, Sleep Apnea, Obstructive, Hypertension, CTCAEDeregulated Nutrient SensingPostoperative weight loss and partial or full resolution of: type 2 diabetes mellitus (T2DM), hypertension (HTN), dyslipidaemia and obstructive sleep apnoea (OSA).25164850
Lipodystrophy, DyslipidemiasDeregulated Nutrient SensingMechanisms responsible for lipodystrophy, dyslipidemia and insulin resistance (IR) occurrence have not been completely understood.25166438
HypertriglyceridemiaDeregulated Nutrient SensingThe increased concentration of FFAs is suggested to be the triggering event in the development of hypertriglyceridemia and insulin resistance during ARV therapy.25166438
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingSIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.25167838
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingTo test hypothetical benefits of SIRT1 overexpression, we crossbred PrP-Sirt1 mice with two lines of ALS model mice: A high expression line that exhibits a severe phenotype (SOD1G93A-H) or a low expression line with a milder phenotype (SOD1G93A-L).25167838
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingThe genetic supplementation of SIRT1 can ameliorate a mutant SOD1-linked ALS mouse model partly through the activation of the HSF1/HSP70i chaperone system.25167838
DyslipidemiasDeregulated Nutrient SensingHigher achieved BP values tended to be associated with an increased CVD risk in both the patients with and without dyslipidemia.25168847
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAt the time of the coronary event, CVRF were highly prevalent (60.5% hypertension, 48% dyslipidemia, and 16% diabetes mellitus).25170515
NeoplasmsDeregulated Nutrient SensingWe hypothesized that the elevated b-HCG and possibly other placental hormones from the germ cell tumor caused her to develop insulin resistance and inadequate b-cell insulin secretory response.25171445
DyslipidemiasDeregulated Nutrient SensingA previous study reported that the myosin regulatory light chain interacting protein (MYLIP) might serve as a novel therapeutic class for treating dyslipidemia.25171759
ObesityDeregulated Nutrient SensingFuture studies should investigate whether a reduction in obesity and insulin resistance may prevent the adverse cardiovascular consequences of altered autonomic function.25171899
Hyperlipidemia, Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingIn familial combined hyperlipidemia (FCHL) the severity of the dyslipidemia is determined by an overproduction of VLDL (very low density lipoprotein) particles and by its abnormal lipid composition.25172037
Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTo report additional ocular outcomes of intensive treatment of hyperglycemia, blood pressure, and dyslipidemia in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study.25172198
DyslipidemiasDeregulated Nutrient SensingThe dyslipidemia trial compared fenofibrate plus simvastatin with placebo plus simvastatin.25172198
Dyslipidemias, Blood GlucoseDeregulated Nutrient SensingAs previously reported, there were significant reductions in the primary outcome in the glycemia and dyslipidemia trials, but no significant effect in the blood pressure trial.25172198
InflammationDeregulated Nutrient SensingPrevious studies have suggested that this is due partly to lower levels of inflammation and insulin resistance.25173442
Malignant tumor of colon, DyslipidemiasDeregulated Nutrient SensingDyslipidemia, insulin resistance, and oxidative stress indices were worsened in obese patients with colon cancer.25173531
Dyslipidemias, Cardiovascular Diseases, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia and elevated lipoprotein(a) are risk factors for adult cardiovascular disease and stroke.25174567
NeoplasmsDeregulated Nutrient SensingThe tumor suppressor LKB1 gene is a master kinase and inhibits mammalian target of rapamycin (mTOR) by activating AMP-activated protein kinase (AMPK) and AMPK-related kinases.25179843
Fibrosis AssessmentDeregulated Nutrient SensingSirt1 regulates canonical TGF-b signalling to control fibroblast activation and tissue fibrosis.25180292
Sample Size Calculation, Systemic SclerodermaDeregulated Nutrient SensingAs aberrant epigenetic modifications have been linked to the pathogenesis of systemic sclerosis (SSc), we aimed to investigate the role of Sirt1 in fibroblast activation.25180292
Fibrosis AssessmentDeregulated Nutrient SensingThe role of Sirt1 was evaluated in bleomycin-induced skin fibrosis and in mice overexpressing a constitutively active transforming growth fac-tor-b (TGF-b) receptor I (TBRIact).25180292
Sample Size Calculation, Fibrosis AssessmentDeregulated Nutrient SensingThe expression of Sirt1 was decreased in patients with SSc and in experimental fibrosis in a TGF-b-dependent manner.25180292
Fibrosis AssessmentDeregulated Nutrient SensingConsistently, mice with fibroblast-specific knockdown of Sirt1 were less susceptible to bleomycin- or TBRIact-induced fibrosis.25180292
Sample Size CalculationDeregulated Nutrient SensingWe identified Sirt1 as a crucial regulator of TGF-b/Smad signalling in SSc.25180292
Sample Size CalculationDeregulated Nutrient SensingAlthough Sirt1 is downregulated, this decrease is not sufficient to counterbalance the excessive activation of TGF-b signalling in SSc.25180292
Sample Size CalculationDeregulated Nutrient SensingSirt1 may thus be a key regulator of fibroblast activation in SSc.25180292
Increased insulin level, Hypertriglyceridemia, Fatty degeneration, HyperglycemiaDeregulated Nutrient SensingSimple steatosis, hyperinsulinemia, hyperglycemia, insulin resistance, hypertriglycemia and marked increases in hepatic CYP2E1 and 4-HNE were present in 30-wk-old untreated OLETF rats.25180626
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe T-455C and C-482T polymorphisms of the APOC3 gene are not associated with risk of NAFLD, pathogenic changes in lipid profiles, or insulin resistance in Han Chinese.25180874
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingWe investigated the associations between breakfast consumption (frequency and content) and risk markers for type 2 diabetes (particularly insulin resistance and glycaemia) and cardiovascular disease in children.25181492
Carcinoma of lung, Malignant NeoplasmsDeregulated Nutrient SensingSirt1 was reported to be overexpressed in many cancers, including lung cancer.25184156
Primary malignant neoplasmDeregulated Nutrient SensingSirtinol, a specific inhibitor of Sirt1, has been shown to induce apoptosis of cancer cells by elevating endogenous level of reactive oxygen species.25184156
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingOverall, this study demonstrates that sirtinol attenuates the proliferation and induces apoptosis of NSCLC cells, indicating the potential treatment against NSCLC cells by inhibiting Sirt1 in future applications.25184156
Fibrosis Assessment, Fatty degeneration, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPrognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia.25186086
Fibrosis Assessment, Fatty degeneration, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTo evaluate the prognostic value of non-invasive biomarkers of liver fibrosis (FibroTest) and steatosis (SteatoTest) in patients with type-2 diabetes and/or dyslipidaemia.25186086
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFibroTest has prognostic value for predicting overall survival in patients with type-2 diabetes and/or dyslipidaemia.25186086
ObesityDeregulated Nutrient SensingObesity modifies the association between serum 25-hydroxyvitamin D and insulin resistance in Korean general population without increased fasting glucose levels.25186304
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingDysregulation of AMPK signaling has been observed in Alzheimer's disease (AD), which is associated with abnormal neuronal energy metabolism.25186765
Depression, CTCAEDeregulated Nutrient SensingWe found that amyloid b (Ab)-induced inhibition of long-term potentiation (LTP) and enhancement of long-term depression were corrected by the AMPK inhibitor compound C (CC).25186765
Failure (biologic function)Deregulated Nutrient SensingIn addition, Ab-induced LTP failure was prevented in mice with genetic deletion of the AMPK a2-subunit, the predominant AMPK catalytic subunit in the brain.25186765
Hyperactive behavior, Data types - AddressDeregulated Nutrient SensingFurthermore, we found that eukaryotic elongation factor 2 (eEF2) and its kinase eEF2K are key downstream effectors that mediate the detrimental effects of hyperactive AMPK in AD pathophysiology.25186765
Data types - Address, SMAD1 protein, humanDeregulated Nutrient SensingOur findings describe a previously unrecognized role of aberrant AMPK signaling in AD-related synaptic pathophysiology and reveal a potential therapeutic target for AD.25186765
Shock, Asthma, Heat-Shock Response, Intimal proliferationDeregulated Nutrient SensingHeat shock protein 20 (HSP20), which is a member of the small heat shock protein family, is known to participate in many pathological processes, such as asthma, intimal hyperplasia, and insulin resistance.25187324
DyslipidemiasDeregulated Nutrient SensingElevated resting heart rate is associated with dyslipidemia in middle-aged and elderly Chinese.25189606
TG gene, DyslipidemiasDeregulated Nutrient SensingTheir resting heart rate was monitored and their serum levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults.25189606
Primary malignant neoplasmDeregulated Nutrient SensingSIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics.25189993
NeoplasmsDeregulated Nutrient SensingExposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target.25189993
Neoplasms, Primary malignant neoplasm, Toxic effectDeregulated Nutrient SensingJQ-101 suppressed cancer cell growth and survival by targeting SIRT1, and also exhibited selective cytotoxicity towards a panel of human tumor cell lines, while producing no toxicity in two normal human cell types at comparable concentrations.25189993
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingIn summary, we have identified JQ-101 as a new SIRT1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion.25189993
Cardiomyopathies, Diabetes MellitusDeregulated Nutrient SensingImportance should be given to the examination of clinical aspects as well as the interdisciplinary follow-up for proper detection of insulin resistance and diabetes, early puberty, cardiomyopathy, among others.25192534
diabeticDeregulated Nutrient SensingThe key cardiac pro-survival cellular signals including AMPK, Akt, ERK1/2, and GSK3a/b were impaired in the diabetic hearts, but the administration of desacyl ghrelin attenuated these signalling impairments.25192951
Cardiac dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results collectively demonstrate that desacyl ghrelin protects the heart against cardiac dysfunction in type 2 diabetic mice by inhibiting excessive collagen deposition and enhancing cardiac autophagic signalling via the pro-survival cellular AMPK/ERK1/2 signalling pathways.25192951
Dyslipidemias, Coronary Artery Disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity is a major risk factor for arterial hypertension, coronary artery disease, dyslipidemias, and type 2 diabetes.25194752
DyslipidemiasDeregulated Nutrient SensingThe prevalence and determinants of dyslipidemia patterns among Hispanics/Latinos are not well known.25195188
DyslipidemiasDeregulated Nutrient SensingDominicans consistently had a lower prevalence of most types of dyslipidemia.25195188
DyslipidemiasDeregulated Nutrient SensingIn multivariate analyses, the presence of any dyslipidemia was associated with increasing age, body mass index, and low physical activity.25195188
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOlder age, female sex, diabetes, low physical activity, and alcohol use were associated with specific dyslipidemia types.25195188
DyslipidemiasDeregulated Nutrient SensingSpanish-language preference and lower educational status were associated with higher dyslipidemia prevalence.25195188
Nonalcoholic SteatohepatitisDeregulated Nutrient SensingRelationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis.25195551
Hepatobiliary DisorderDeregulated Nutrient SensingA total of 239 patients were recruited and state-of-the-art techniques were used to measure insulin resistance (euglycemic insulin clamp with 3-(3)H-glucose), liver fat accumulation (magnetic resonance spectroscopy or (1)H-MRS), total body fat (dual energy X-ray absorptiometry), and severity of liver disease (liver biopsy).25195551
Fatty Liver DiseaseDeregulated Nutrient SensingAlthough patients with NASH had higher insulin resistance, plasma vitamin D concentrations were similar between both groups.25195551
Fatty Liver DiseaseDeregulated Nutrient SensingOur results suggest that plasma vitamin D levels are not associated with insulin resistance, the amount of liver fat accumulation, or the severity of NASH.25195551
Idiopathic hirsutismDeregulated Nutrient SensingA threshold of 74.5 cm for waist circumference had the optimal combined sensitivity and specificity for prediction of insulin resistance in women with idiopathic hirsutism, though this value was 90.5 cm for controls.25200999
DyslipidemiasDeregulated Nutrient SensingSpecifically, the a-carotene and b-cryptoxanthin LSCRS were associated with a lower odds of HDL-C dyslipidaemia.25201307
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Diabetes MellitusDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is prevalent in reproductive-aged women and confounded by metabolic morbidities, including insulin resistance and type 2 diabetes.25207967
Glucose Intolerance (disease)Deregulated Nutrient SensingTogether, these data suggest in utero androgen excess combined with mild maternal glucose intolerance alter infant and adult islet morphology, implicating deviant islet development.25207967
NeoplasmsDeregulated Nutrient SensingOur study relies on a 'signal transduction' hypothesis based on the crosstalk between LKB1/AMPK and PI3K/PTEN/Akt signaling at the level of the tumor suppressor protein FoxO3A.25208626
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingQuality of care (QoC) was calculated by measuring provider performance on four indicators (antiplatelet therapy, dyslipidemia management, control of hypertension, and diabetes) derived from the ACCF/AHA PAD guidelines.25209120
Thyroid carcinomaDeregulated Nutrient SensingInsulin resistance is another factor that increases the risk of recurrence in patients with thyroid cancer.25209891
In-Stent Restenosis IndicatorDeregulated Nutrient SensingInfluence of insulin resistance on in-stent restenosis in patients undergoing coronary drug-eluting stent implantation after long-term angiographic follow-up.25211654
In-Stent Restenosis IndicatorDeregulated Nutrient SensingPrevious studies have reported that insulin resistance is related to early in-stent restenosis (ISR) after coronary stenting.25211654
Hypertensive (finding)Deregulated Nutrient SensingRelationships of plasma lipoprotein(a) levels with insulin resistance in hypertensive patients.25212579
Hypertensive (finding)Deregulated Nutrient SensingInsulin resistance and higher fasting insulin levels are associated with lower plasma Lp(a) in hypertensive patients.25212579
Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Diabetes MellitusDeregulated Nutrient SensingFrequencies of hypertension and diabetes mellitus were unchanged, whereas dyslipidemia, smoking, and atrial fibrillation significantly increased.25213341
phosphorus 32Deregulated Nutrient SensingIt is our hypothesis that activation of AMP-activated protein kinase (AMPK), a master regulator of cellular metabolism, may lead to a reduction in SRSF1 and thus a decrease in the use of the LMNA 5' cryptic splice site in exon 11 through upregulation of p32, a splicing factor-associated protein and putative mitochondrial chaperone that has been shown to inhibit SRSF1 and enhance mitochondrial DNA (mtDNA) replication and oxidative phosphorylation.25216752
DiseaseDeregulated Nutrient SensingAMPK activation by currently available compounds such as metformin, resveratrol, and berberine may thus have wide-ranging implications for disorders associated with increased production and accumulation of progerin.25216752
Impaired cognition, Demographics DomainDeregulated Nutrient SensingThese results suggest that cognitive and affective decline in DM patients was mostly related to glucose control and insulin resistance, whilst amongst late elderly subjects the impairment of 'attention' and 'orientation' were characteristic features of DM patients.25220803
Prostate Cancer Outcomes Study, metabolic disturbanceDeregulated Nutrient SensingThe decrease of SHBG level was also a risk factor for insulin resistance in both PCOS and metabolic disturbance.25223276
Osteoporosis, Dyslipidemias, Behavior Disorders, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingPatients with SCS have a high prevalence of "lifestyle-related diseases," such as hypertension, diabetes mellitus, dyslipidemia, and osteoporosis.25223468
diabeticDeregulated Nutrient SensingFresh pomegranate juice ameliorates insulin resistance, enhances b-cell function, and decreases fasting serum glucose in type 2 diabetic patients.25223711
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGenerally, the results demonstrated decreased FSG, increased b-cell function, and decreased insulin resistance among T2D participants, 3 hours after PJ administration (P < .05).25223711
Huntingtons Disease PathwayDeregulated Nutrient SensingAn exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.25223731
HD Term Type, "Huntingtons Disease PathwayDeregulated Nutrient SensingSelisistat, a selective SirT1 inhibitor is being developed as a potentially disease-modifying therapeutic for Huntington's disease (HD).25223731
Dyslipidemias, diabeticDeregulated Nutrient SensingCardiovascular risk and prevention may be improved in revascularized diabetic patients in Spain through further control of risk factors, particularly dyslipidemia.25224523
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingHowever, endothelial dysfunction on the one hand and type 2 diabetes mellitus, impaired glucose metabolism (IGM), and insulin resistance on the other may act synergistically (ie, interact) in the development of cardiovascular disease.25225211
Immunoglobulin M, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe therefore investigated the interaction between endothelial dysfunction and type 2 diabetes mellitus, IGM, and insulin resistance with regard to risk of cardiovascular events.25225211
Immunoglobulin M, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInteraction between flow-mediated dilatation and type 2 diabetes mellitus, IGM, or insulin resistance was present on an additive (relative excess risk caused by interaction>0) and on a multiplicative scale (P interaction<0.05).25225211
Immunoglobulin M, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEndothelial dysfunction and type 2 diabetes mellitus, IGM, or insulin resistance synergistically increase cardiovascular event risk.25225211
Autoimmune Diseases, Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-Dependent, Beta-Cell Function MeasurementDeregulated Nutrient SensingIslet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes.25226365
OsteoporosisDeregulated Nutrient SensingWe performed a prospective monocentric study of patients with osteoporosis and measured the nuclear and cytoplasmic activities of SIRT1 in PBMCs.25228047
OsteoporosisDeregulated Nutrient SensingSirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis.25228047
PPARG wt AlleleDeregulated Nutrient SensingThe conserved acetylation sites of Pparg1 and the catalytic domain of SIRT1 are both required for the interaction between Pparg1 and SIRT1.25229978
ObesityDeregulated Nutrient SensingVitamin D deficiency is associated with insulin resistance in nondiabetics, which is independent of obesity.25230322
ProgranulinsDeregulated Nutrient SensingProgranulin (PRGN) was recently identified as one of the adipokines involved in the development of insulin resistance.25231693
DyslipidemiasDeregulated Nutrient SensingCommon vascular risk factors (dyslipidemia, smoking, and sex) were similar for normal, low, and incompressible ABix.25231881
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic b-cell function, and inflammation.25233153
Chronic Obstructive Airway Disease, Hypertension, CTCAE, Depression, CTCAE, DyslipidemiasDeregulated Nutrient SensingOther variables: gender, age, depression, asthma/chronic obstructive pulmonary disease, hypertension, dyslipidemia, insulin, pills, smoking, walking, baseline blood glucose and creatinine.25234387
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced b-cell mass, partially due to an increased b-cell apoptosis rate.25234740
Inflammation, square decimeter, ObesityDeregulated Nutrient SensingChronic inflammation is linked to disorders of obesity, insulin resistance and DM2.25236830
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension was diagnosed in 19%, dyslipidemia in 27%, and diabetes mellitus in 3%.25238104
Fibrosis AssessmentDeregulated Nutrient SensingThe creation of a transverse aortic constriction (TAC) provoked more severe DD and LV fibrosis in Sirt1(endo-/-) compared with control TAC animals.25239805
Diastolic dysfunctionDeregulated Nutrient SensingSirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction.25239805
CardiomyopathiesDeregulated Nutrient SensingSirtuin 1 expression declines with age; therefore we explored the role played by angiogenesis and Sirtuin 1 in the development of cardiomyopathy.25239805
DyslipidemiasDeregulated Nutrient SensingAdded sugar consumption seems to trigger a hyperinflammatory state and may result in visceral adiposity, dyslipidemia, and insulin resistance.25240081
Obesity, Diabetes MellitusDeregulated Nutrient SensingImpacts of diet quality on insulin resistance, as a sign of metabolism perturbation, deserve more attention in this indigenous population with high rates of obesity and diabetes.25240691
palladium, Overweight, DysglycemiaDeregulated Nutrient SensingOverweight adolescents with PD have an atherogenic lipoprotein profile of small LDL and HDL size and increased concentrations of small LDL, moderated by insulin resistance and visceral adiposity, but independently driven by dysglycemia for LDL size.25240909
Oxygen saturation below reference range, Slow shallow breathingDeregulated Nutrient SensingCorrelations between Apneea Hypopnea Index (AHI), Oxygen Desaturation Index (ODI), average and lowest oxyhaemoglobin saturation (SaO), body mass index (BMI) and insulin resistance or sensitivity were assesed.25241557
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingA subcutaneous adipose tissue biopsy displayed changes in gene and protein expression that could contribute to the clinical improvement of hyperglycemia and dyslipidemia.25242791
HypoxiaDeregulated Nutrient SensingFurthermore, we observed a consistent reduction of tubule-like formation and migration and we found that SIRT1 inhibition reduced the hypoxia induced accumulation of HIF-1a protein and its transcriptional activity in hMSCs.25243179
Spinal Cord IschemiaDeregulated Nutrient SensingOur findings identify SIRT1 as regulator of hypoxia-induced response in hMSCs and may contribute to the development of new therapeutic strategies to improve regenerative properties of mesenchymal stem cells in ischemic disorders through SIRT1 modulation.25243179
Acid reflux, Quadriplegia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThis 68-year-old male with chronic incomplete tetraplegia, dyslipidemia, and well-controlled diabetes mellitus underwent Roux-en-Y gastric bypass surgery (RYGBP) for intractable biliary reflux.25243335
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingSurrogate markers reflecting b-cell dysfunction were more closely associated with diabetes conversion than insulin resistance indices.25245975
Cardiovascular DiseasesDeregulated Nutrient SensingThe effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease.25252293
Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingParticularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet.25252293
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingElevated oxidative stress contributes to the development of such obesity-related diseases as dyslipidemia, diabetes mellitus and hypertension.25252747
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, HyperlipidemiaDeregulated Nutrient SensingLow-grade inflammation, characterized by increased pro-inflammatory cytokine levels, is present in patients with obesity-linked insulin resistance, hyperglycemia and hyperlipidemia and considered to play a leading role to progression into type 2 diabetes (T2D).25254631
Thrombosis, Dyslipidemias, Venous Thromboembolism, vinyltriethoxysilaneDeregulated Nutrient SensingDyslipidemia is a well-known risk factor for the development of atherothrombosis; however, its involvement in venous thromboembolism (VTE) is still debated.25256037
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingActivation of AMP-activated protein kinase a1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.25256353
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingIn this study, we demonstrate that cytoplasmic mislocalization of TDP-43 was accompanied by increased activation of AMP-activated protein kinase (AMPK) in motor neurons of ALS patients.25256353
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingThe activation of AMPK in a motor neuron cell line (NSC34) or mouse spinal cords induced the mislocalization of TDP-43, recapitulating this characteristic of ALS.25256353
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingOur findings demonstrate that activation of AMPK-a1 plays a critical role in TDP-43 mislocalization and the development of ALS; thus, AMPK-a1 may be a potential drug target for this devastating disease.25256353
Dyslipidemias, Sleep Apnea Syndromes, Degenerative polyarthritis, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with very high to extremely high WRHR often had type 2 diabetes mellitus; hypertension; dyslipidaemia; osteo arthritis; and sleep apnoea.25257816
IFNG wt Allele, Glucose Intolerance (disease), Depressed mood, Demographics DomainDeregulated Nutrient SensingA depressed mood for 2 or more continuous weeks was reported by 13.6% of subjects with normal glucose tolerance (NGT), 14.3% of those with impaired glucose intolerance (IFG), and 17.6% of DM patients.25258359
Glucose Intolerance (disease), Obesity, Primary malignant neoplasmDeregulated Nutrient SensingPDAC has been linked with obesity and glucose intolerance, but whether changes in circulating metabolites are associated with early cancer progression is unknown.25261994
Demographics Domain, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Haiti, Hypertension, CTCAE, Dental PlaqueDeregulated Nutrient SensingThe purpose of this study was to investigate the difference of coronary artery disease (CAD) severity and extent as well as plaque characteristics between patients with either one of hypertension (HT), diabetes mellitus (DM) or dyslipidemia (DL).25262436
Chronic liver diseaseDeregulated Nutrient SensingInsulin resistance has been described in association with chronic liver disease for decades.25263463
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingContrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up.25264116
Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is commonly proposed as a precursor to both type 2 diabetes and cardiovascular disease (CVD), yet few studies have directly compared insulin resistance with both outcomes simultaneously and determined whether associations with each outcome differ in strength or are comparable.25264116
Diabetes MellitusDeregulated Nutrient SensingOur data support insulin resistance as a predictor of diabetes in later life but, perhaps surprisingly, suggest this pathway is of negligible importance to CVD outcomes in the elderly.25264116
InflammationDeregulated Nutrient SensingIncreased permeability and uptake of proinflammatory bacterial endotoxins from gut microbiota has been suggested as a mechanism for obesity-associated chronic inflammation that causes obesity-associated insulin resistance.25264329
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingTherefore, because ALT is correlated with dyslipidemia, insulin resistance, and central fat distribution, it might also serve as a marker of risk for adiposity-related co-morbidities beyond NAFLD.25266069
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSeveral markers of iron metabolism have been associated with insulin resistance (IR) and type 2 diabetes mellitus in cross-sectional studies.25267079
Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance has an important role in the pathogenesis of hypertension.25267735
Hypertensive (finding), Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingAt baseline, the prevalence of abdominal obesity, dyslipidemia, and IGT was higher in subjects who became hypertensive compared to those that remained normotensive.25267735
Endometrial NeoplasmsDeregulated Nutrient SensingSIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.25270091
Carcinogenesis, NeoplasmsDeregulated Nutrient SensingRecent studies have revealed that SIRT1 plays a dual role as a tumor suppressor and a tumor promoter in multiple stages of carcinogenesis.25270091
Endometrial Neoplasms, NeoplasmsDeregulated Nutrient SensingThese results demonstrated that SIRT1 may play a role as a tumor promoter in EC and can promote endometrial tumor growth by promoting lipogenesis.25270091
Carotid AtherosclerosisDeregulated Nutrient SensingGenetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort.25273948
atheroscleroticDeregulated Nutrient SensingSIRT1 and FOXO1 interact with each other in multiple pathways regulating aging, metabolism and resistance to oxidative stress and control different pathways involved in atherosclerotic process.25273948
AtherosclerosisDeregulated Nutrient SensingIt is not known, if genetic polymorphisms (SNPs) at the SIRT1 and FOXO1 have an influence on carotid atherosclerosis.25273948
Carotid AtherosclerosisDeregulated Nutrient SensingThis study demonstrated associations of genetic variations at the SIRT1 and FOXO1 loci with carotid atherosclerosis and highlighted the need for further investigation by functional studies.25273948
Diabetic Retinopathy, Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response TerminologyDeregulated Nutrient SensingThis study was designed to investigate the association between the polymorphisms in three insulin resistance-related genes, uncoupling protein-1 (UCP1), peroxisome proliferator-activated receptor g (PPARg) and transcription factor 7-like 2 (TCF7L2) and the susceptibility to diabetic retinopathy (DR) in a Chinese type 2 diabetes mellitus (T2DM) cohort.25274455
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe occurrence of the MS process mostly began with overweight or obesity and dyslipidemia in young people.25280459
Hypertensive disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThirteen patients (19.1 %) had HTN; 7 (10.2 %) had dyslipidemia and 6 (8.8 %) had diabetes not requiring treatment.25282446
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingA comprehensive cardiovascular disease (CVD) risk factor profile was assessed including demographics, environmental and biochemical risk factors including insulin resistance and troponin-T levels.25283732
Dyslipidemias, Coronary heart disease, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingMultiple logistic regression analysis revealed that the significant predictors of vitamin D deficiency included coronary heart disease (CHD), obesity, dyslipidemia, older age, female sex, and smoking (all P<0.05), whereas tea intake, moderate physical activity, milk intake, vitamin D supplementation and sun exposure were protective (all P<0.05).25284157
Dyslipidemias, Obesity, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingVitamin D deficiency is prevalent in the middle-aged and elderly northwestern Chinese population and is largely attributed to CHD, obesity, dyslipidemia, older age, female sex, and smoking.25284157
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThese patients were younger (median 56.7 vs. 62.1years, P<0.0001) and more often current smokers (52.4% vs. 43.5%, P<0.0001), had more dyslipidemia (47.7% vs. 41.1%, P=0.0003), less diabetes mellitus (14.1% vs. 17.5%, P=0.01) and had shorter symptom onset to balloon times (median 213 vs. 225 min, P=0.02).25288517
Non-alcoholic Fatty Liver Disease, Impaired healthDeregulated Nutrient SensingThis impairment may affect HSP70-dependent anti-inflammation, with consequent oxidative stress and insulin resistance in advanced stages of NAFLD.25292174
Dyslipidemias, Atherosclerosis, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia is a major contributor to the development of atherosclerosis and coronary disease.25292185
ObesityDeregulated Nutrient SensingThe reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity.25296075
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia and its association with insomnia in a community based population in China.25297696
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingStudies of the prevalence of dyslipidemia and its association with insomnia are scarce in China.25297696
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingThis study investigated the prevalence of dyslipidemia and its association with insomnia in a community based Chinese population.25297696
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingThe association between self-reported insomnia and dyslipidemia was determined by multiple logistic regression models.25297696
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia in those with no insomnia, occasional insomnia, and frequent insomnia were 53.3%, 54.3%, and 54.5% in men and 52.0%, 54.8%, and 61.2% in women.25297696
Sleeplessness, DyslipidemiasDeregulated Nutrient SensingThese observations indicate that frequent insomnia was associated with a higher prevalence of dyslipidemia in women.25297696
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingHypothyroidism is one of the most common causes of secondary dyslipidemias which results from reduced LDL clearance and therefore raised levels of LDL and apoB.25300222
Hypoalphalipoproteinemias, DyslipidemiasDeregulated Nutrient SensingThe most frequent MS group was hypoalphalipoproteinemia in females (51.3%) and mixed dyslipidemia in males (43.5%).25300324
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingManagement of dyslipidemia in high-risk patients with preexistent CAD or stroke continues to be suboptimal.25300975
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingOur results suggest that the expression of alpha-defensins 1, 2 and 3 genes is involved in dyslipidemia in patients with hypercholesteremia.25300997
Obesity, Abdominal, OverweightDeregulated Nutrient SensingAbdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study.25301371
OverweightDeregulated Nutrient SensingHowever, these associations are unclear amongst overweight adolescents who have already developed insulin resistance.25301371
OverweightDeregulated Nutrient SensingThe risk of insulin resistance amongst overweight adolescents increases significantly when they reach a waist circumference > p95 (OR = 1.9, CIs = 1.3-2.7, p = 0.013) and watch 3 or more hours/day of television (OR = 1.7, CIs = 0.98-2.8, p = 0.033).25301371
OverweightDeregulated Nutrient SensingSedentary behaviour and a waist circumference > p90 amongst overweight adolescents were associated with insulin resistance, lipid profile alterations, and higher inflammatory states.25301371
Cardiovascular DiseasesDeregulated Nutrient SensingWe conclude that the android/gynoid fat ratio is closely associated with insulin resistance and LDL + VLDL-, "bad," cholesterol in normal weight boys and may provide a measurement of metabolic and cardiovascular disease risk in that population.25302115
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCirculating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance.25303484
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingCompared to non-obese patients without NAFLD, patients with NAFLD had severe systemic (liver/muscle), and particularly, adipose tissue (fasting/postprandial) insulin resistance (all p<0.01).25303488
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance is considered one of the major risk factors for the development of type 2 diabetes mellitus (T2DM).25303644
AtherosclerosisDeregulated Nutrient SensingThe triglycerides-to-high-density lipoprotein-cholesterol (TG/HDL-C) ratio has been identified as a biomarker of insulin resistance and a predictor for atherosclerosis.25304295
One Vessel Coronary Disease, Dyslipidemias, Diabetes Mellitus, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingAll had chronic stable angina, 75% had dyslipidemia, 58% had hypertension, 50% had peripheral arterial disease, 42% had diabetes and 50% had multivessel disease.25304770
Dyslipidemias, Prostate carcinomaDeregulated Nutrient SensingGiven that prostate cancer and dyslipidemia affect large proportions of Western society, understanding these associations has public health importance.25304929
DyslipidemiasDeregulated Nutrient SensingHowever, among men with dyslipidemia, elevated cholesterol and HDL levels were associated with increased and decreased risk of recurrence, respectively.25304929
RANGAP1 wt Allele, Frontotemporal dementiaDeregulated Nutrient SensingBoth patients with bvFTD and those with SD have increased triglyceride and insulin levels and lower HDL cholesterol levels compared with controls, suggesting a state of peripheral insulin resistance.25305153
Nerve DegenerationDeregulated Nutrient SensingThese factors have been found to affect prognosis in motor neuron disease favorably, although insulin resistance has been proposed as a mechanism promoting neurodegeneration.25305153
Diabetes MellitusDeregulated Nutrient SensingSphingolipids are increasingly recognized to play a role in insulin resistance and diabetes.25305670
Myeloid Leukemia, Chronic, DyslipidemiasDeregulated Nutrient SensingStatin therapy for dyslipidemia was associated with a lower incidence of multiple lesions and a lower concentration of CML in the protein sample (P = .004 and P = .02, respectively).25307432
Dyslipidemias, Overweight, Hypertension, CTCAE, diabeticDeregulated Nutrient SensingDiabetic patients were significantly older, had a worse cardiovascular risk profile (higher prevalence of overweight, dyslipidemia, hypertension and sedentary lifestyle) and lower functional capacity.25307705
Colorectal CarcinomaDeregulated Nutrient SensingThe aim of this study was to investigate the clinical prognostic value of the histone deacetylases SIRT1, HDAC1 and HDAC2 and the histone modifications H4K16Ac and H3K56Ac in colorectal cancer.25307864
Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingMarkers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease.25310839
Impaired T cell function, Metabolic Syndrome XDeregulated Nutrient SensingOur findings suggest that environmental exposure to PAHs independent of cigarette smoking is associated with insulin resistance, b-cell dysfunction, and increased prevalence of metabolic syndrome.25310882
Dyslipidemias, Liver CirrhosisDeregulated Nutrient SensingReduced dyslipidemia in patients with cirrhosis is associated with increased insulin resistance and possibly failed lipid synthesis.25311381
Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingAlthough NAFLD is associated with dyslipidemia, it is not clear whether recently identified markers of cardiovascular risk indicate liver disease progression in patients with histologically confirmed NAFLD.25311381
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia is related to increased insulin-induced hepatic lipid synthesis in patients with NAFLD.25311381
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingAmong the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial.25311932
Malignant neoplasm of liver, Weight decreased, ObesityDeregulated Nutrient SensingThe epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer.25313081
Dyslipidemias, Bipolar Disorder, diabeticDeregulated Nutrient SensingWaist-to-hip ratio, dyslipidemia, glycemic levels, blood pressure and depressive symptoms among diabetic and non-diabetic Chinese women: a cross-sectional study.25314156
Dyslipidemias, Bipolar Disorder, diabeticDeregulated Nutrient SensingTo explore the relationship between depressive symptoms and waist-to-hip ratio, dyslipidemia, glycemic levels or blood pressure among diabetic and non-diabetic Chinese women.25314156
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Cerebrovascular accident, Hypertension, CTCAEDeregulated Nutrient SensingData on demographic information, lifestyle, history of diabetes mellitus, stroke, coronary heart disease, hypertension, and dyslipidemia were collected.25316225
Glucose Intolerance (disease)Deregulated Nutrient SensingCopious evidence from epidemiological and laboratory studies has revealed that sleep status is associated with glucose intolerance, insulin resistance, thus increasing the risk of developing type 2 diabetes.25316226
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes.25320095
Lipodystrophy, DyslipidemiasDeregulated Nutrient SensingOlder age, increased duration of treatment and dyslipidaemia were found to be associated in patients with lipodystrophy than those without.25320591
Impaired T cell functionDeregulated Nutrient SensingOxidative stress has been hypothesised to contribute to the development of insulin resistance and b-cell dysfunction, the two key events in the clinical development of T2DM.25322842
Bipolar DisorderDeregulated Nutrient SensingLittle is known about the impact of insulin resistance on bipolar disorder.25323142
Diabetes Mellitus, Bipolar DisorderDeregulated Nutrient SensingTo examine the relationships between insulin resistance, type 2 diabetes and clinical course and treatment outcomes in bipolar disorder.25323142
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe diagnosed type 2 diabetes and determined insulin resistance.25323142
Diabetes Mellitus, Non-Insulin-Dependent, Bipolar DisorderDeregulated Nutrient SensingPatients with bipolar disorder and type 2 diabetes or insulin resistance had three times higher odds of a chronic course of bipolar disorder compared with euglycaemic patients (50% and 48.7% respectively v. 27.3%, odds ratio (OR) = 3.07, P = 0.007), three times higher odds of rapid cycling (38.5% and 39.5% respectively v. 18.2%, OR = 3.13, P = 0.012) and were more likely to be refractory to lithium treatment (36.8% and 36.7% respectively v. 3.2%, OR = 8.40, P<0.0001).25323142
GDC Comorbidity Terminology, Bipolar DisorderDeregulated Nutrient SensingComorbid insulin resistance may be an important factor in resistance to treatment in bipolar disorder.25323142
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHe had a medical history of well-controlled diabetes, hypertension and dyslipidaemia.25323280
Endometrial Carcinoma, DyslipidemiasDeregulated Nutrient SensingWe previously reported an association between dyslipidemia and endometrial cancers.25324478
Dyslipidemias, OsteoporosisDeregulated Nutrient SensingA common etiologic event has been proposed between dyslipidemia and osteoporosis.25324478
Dyslipidemias, Malignant neoplasm of endometrium, OsteoporosisDeregulated Nutrient SensingHowever, the pattern of interrelationships among dyslipidemia, osteoporosis and endometrial cancer is not well understood.25324478
Cardiovascular systemDeregulated Nutrient SensingParadoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans.25326285
Chronic diseaseDeregulated Nutrient SensingInsulin resistance is linked to many human chronic diseases.25326285
glucose metabolismDeregulated Nutrient SensingWe formulated a novel hypothesis that insulin resistance can be beneficial in obese humans, insofar as it does not cause glucose dysmetabolism.25326285
glucose metabolismDeregulated Nutrient SensingInsulin resistance in obese individuals may begin as an adaptive mechanism and can be beneficial if it is not associated with glucose dysmetabolism.25326285
Glucose Intolerance (disease), cardiac symptomDeregulated Nutrient SensingLeft axis deviation in electrocardiogram with normal QRS duration in ambulatory adults without cardiac symptoms: a possible marker of glucose intolerance.25327226
Dyslipidemias, Atherosclerosis, Disease, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, a disorder in the levels of cholesterol or lipoproteins in the plasma, is a feature of atherosclerosis, leading to cardiovascular disease.25328922
Cardiovascular DiseasesDeregulated Nutrient SensingMorbidly obese patients are at risk of developing insulin resistance and cardiovascular disease.25329451
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFurther studies are needed to determine whether the use of metformin will prevent the progression of insulin resistance to type 2 diabetes mellitus in obese women.25333776
Dyslipidemias, Endothelial dysfunction, Pathology, AtherosclerosisDeregulated Nutrient SensingEndothelial dysfunction is an early event in the progression of atherosclerosis, and it appears in pathologies such as dyslipidemias.25333861
Malignant Head and Neck Neoplasm, diabeticDeregulated Nutrient SensingEffect of L-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery.25335675
Diabetes MellitusDeregulated Nutrient SensingPrevious studies have found that L-arginine induced beneficial effects over insulin resistance both in type 2 diabetes mellitus patients and healthy individuals.25335675
Malignant Head and Neck Neoplasm, Diabetes MellitusDeregulated Nutrient SensingShort-term enteral L-arginine therapy addeded to usual enteral nutrition of patients affected by head and neck cancer and surgery without diabetes mellitus type 2 is able to improve insulin resistance and adiponectin levels.25335675
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans.25337775
Chronic Kidney DiseasesDeregulated Nutrient SensingIn this study, we examined the association between chronic kidney disease (CKD) and insulin resistance.25337775
Uremia, SubstanceDeregulated Nutrient SensingIn the adipose tissue of nephrectomized rats, asymmetric dimethylarginine (ADMA; an uremic substance linking uremia and insulin resistance) increased, the expression of the ADMA-degrading enzymes DDAH1 and DDAH2 decreased, and the oxidative stress increased.25337775
Chronic Kidney DiseasesDeregulated Nutrient SensingThus, activation of mineralocorticoid receptor and resultant ADMA accumulation in adipose tissue has, in part, a relevant role in the development of insulin resistance in CKD.25337775
Diabetes MellitusDeregulated Nutrient SensingSerum ferritin, diabetes, diabetes control, and insulin resistance.25338070
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe aim of our study was to show the influence of testosterone replacement therapy on obesity, HbA1c level, hypertension and dyslipidemia in patients with diabetes mellitus and androgen deficiency.25338765
SarcomaDeregulated Nutrient SensingSIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.25341037
synovial sarcomaDeregulated Nutrient SensingWe show that SIRT1 is overexpressed in synovial sarcoma biopsies and cell lines in comparison with normal mesenchymal cells.25341037
Dyslipidemias, Diabetes Mellitus, Obesity, vascular inflammations, Hypertension, CTCAEDeregulated Nutrient SensingSome epidemiological studies have begun to show a possible correlation between systemic and vascular inflammation and the presence of essential hypertension, especially if it is associated with metabolic risk factors (obesity, dyslipidemia, diabetes mellitus).25341276
ObesityDeregulated Nutrient SensingThe biological mechanisms linking obesity to insulin resistance have not been fully elucidated.25341798
ObesityDeregulated Nutrient SensingWe sought to test the hypothesis that the balance of T-cell phenotypes would be similarly related to insulin resistance in human obesity.25341798
Inflammation, ObesityDeregulated Nutrient SensingThese findings point to the adaptive immune system as a potential mediator between obesity and insulin resistance or inflammation.25341798
Alzheimers Disease", square decimeter, Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingInsulin resistance causes diminished glucose uptake in similar regions of the brain in Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2).25342129
square decimeter, Data types - Address, Frontotemporal dementiaDeregulated Nutrient SensingMean exosomal levels of extracted P-serine 312-IRS-1 and P-pan-tyrosine-IRS-1 by ELISA and the ratio of P-serine 312-IRS-1 to P-pan-tyrosine-IRS-1 (insulin resistance factor, R) for AD and DM2 and P-serine 312-IRS-1 and R for FTD were significantly different from those for case control subjects.25342129
square decimeter, Data types - Address, Frontotemporal dementiaDeregulated Nutrient SensingInsulin resistance reflected in R values from this blood test is higher for patients with AD, DM2, and FTD than case control subjects; higher for patients with AD than patients with DM2 or FTD; and accurately predicts development of AD up to 10 yr prior to clinical onset.25342129
Hypertension, CTCAE, Ischemic, DyslipidemiasDeregulated Nutrient SensingGender, age, hypertension, dyslipidaemia, family history, ischaemic ECG and positive troponin remained important factors.25344576
Sleep Apnea, ObstructiveDeregulated Nutrient SensingAbnormalities of lipoprotein concentrations in obstructive sleep apnea are related to insulin resistance.25348129
Dyslipidemias, Osage languageDeregulated Nutrient SensingInsulin resistance is also common in OSA, but its contribution to dyslipidemia of OSA is unclear.25348129
Osage languageDeregulated Nutrient SensingThe study's aim was to define the relationships among abnormalities of lipoprotein metabolism, clinical measures of OSA, and insulin resistance.25348129
Sleep Apnea, Obstructive, Hypoxia, Osage languageDeregulated Nutrient SensingPro-atherogenic lipoprotein abnormalities in obstructive sleep apnea (OSA) are related to insulin resistance, but not to OSA severity or degree of hypoxia.25348129
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance may represent the link between OSA-related dyslipidemia and increased cardiovascular disease risk.25348129
Cardiovascular Diseases, Osage language, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Sleep Apnea, ObstructiveDeregulated Nutrient SensingPrevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia in these individuals.25348129
Allergic asthmaDeregulated Nutrient SensingInsulin resistance is a risk for allergic asthma in obese children and adolescents.25348132
Hypothermia due to exposureDeregulated Nutrient SensingThese results demonstrate increased resistance to insulin during mild induced hypothermia.25349023
Dyslipidemias, OverweightDeregulated Nutrient SensingThe increase in overweight and obese children and adolescents may be linked to increased rates of dyslipidaemia.25351644
DyslipidemiasDeregulated Nutrient SensingLow HDL-chol levels were the most prevalent dyslipidaemia in boys (6.4%) and high TChol in girls (9.1%).25351644
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingPlasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients.25358448
Steatohepatitis, Fatty degenerationDeregulated Nutrient SensingSIRT1 was significantly lower in severe liver steatosis obese group compared to the mild steatosis group, both had lower SIRT1 plasma values compared to control lean patients (P = 0.0001).25358448
SteatohepatitisDeregulated Nutrient SensingSIRT1 showed an inverse correlation with liver steatosis and HbA1c in univariate analysis (r = -0.386; P = 0.001; r = -0.300; P = 0.01, respectively).25358448
SteatohepatitisDeregulated Nutrient SensingMultiple linear regression analysis showed that liver steatosis was the independent correlate of SIRT1 even after adjustment for potentially relevant variables (b = -0.442; P = 0.003).25358448
Fatty LiverDeregulated Nutrient SensingSerum SIRT1 might be a novel clinical/biochemical parameter associated with fat liver infiltration.25358448
Inflammation, Dyslipidemias, HyperglycemiaDeregulated Nutrient SensingInflammation, hyper-glycaemia, dyslipidemia and oxidative stress have been associated with early stages of NCDs development whereas cohort surveys have demonstrated health benefits of dietary polyphenols from various dietary sources to reverse such progress.25358490
Prediabetes syndrome, Coronary heart diseaseDeregulated Nutrient SensingModulation of coronary heart disease risk by insulin resistance in subjects with normal glucose tolerance or prediabetes.25358836
Prediabetes syndrome, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThis study was based on the hypothesis that: (1) coronary heart disease (CHD) risk is accentuated in the insulin-resistant subset of persons with normal glucose tolerance (NGT) or prediabetes (PreDM); (2) the prevalence of insulin resistance, and associated abnormalities, is greater in subjects with PreDM; and (3) insulin resistance is the major contributor to increased CHD risk in these individuals.25358836
Breast CarcinomaDeregulated Nutrient SensingTranslational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer.25361980
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes.25368904
Diabetes MellitusDeregulated Nutrient SensingThe results indicate that teneligliptin acts not only to improve the blood glucose control, but also to improve the insulin resistance and serum lipid profile in Japanese type 2 diabetes patients.25368904
Deterioration, diabeticDeregulated Nutrient SensingThe inverse association between lumbar spine TBS and insulin resistance may make it an indicator for determining skeletal deterioration in diabetic patients who have high BMD.25368976
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingPrevalence of hypothyroidism in patients with dyslipidemia: Tehran Thyroid Study (TTS).25369072
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingIn subjects with dyslipidemia and nondyslipidemia, the prevalence of subclinical was 7% and 4.1%, respectively, and for clinical hypothyroidism 3% and 1.2%, respectively.25369072
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingAfter adjusting for age and sex, hypothyroidism was not related to elevated serum lipid profiles in patient with dyslipidemia.25369072
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingIn conclusion, there is significant difference in the prevalence of subclinical and clinical hypothyroidism between nondyslipidemic and dyslipidemic subjects; after adjustment for age and sex the presence of dyslipidemia did not predict the presence of hypothyroidism.25369072
Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingAtherosclerosis is a chronic and systemic disease and its developmental process involves the synergism of multiple risk factors such as hypertension, dyslipidemia, diabetes, obesity and smoking.25369320
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingDisease activity score (DAS28), clinical and immunological parameters as well as traditional CV risk factors (diabetes, hypertension, dyslipidaemia and obesity) were registered from clinical records and all data were integrated using Principal Component Analysis (PCA).25369551
ObesityDeregulated Nutrient SensingThe insulin resistance state did not mediate this association, while central obesity was a negative confounder.25370350
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSkeletal muscle is the key site of peripheral insulin resistance in type 2 diabetes.25370850
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingMicroarray analysis was performed using skeletal muscle cell cultures established from type 2 diabetic patients with a family history of type 2 diabetes and clinical evidence of marked insulin resistance and nondiabetic control subjects with no family history of diabetes.25370850
FAM126A geneDeregulated Nutrient SensingThere are minor studies of the expression kinetics of mTORC1 and mTORC2 in HCC.25371154
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient Sensing3) The shortest distances in the receiver operating characteristic curves for hypertension, dyslipidemia, diabetes, or >= 2 of these risk factors suggested that the WHR cutoffs were 0.92 or 0.91 for men and 0.86 or 0.85 for women.25376677
Dyslipidemias, Peripheral Arterial Diseases, ObesityDeregulated Nutrient SensingIn multivariate analysis, peripheral artery disease was significantly associated with age (odds ratio (OR): 1.03; p = 0.004), dyslipidaemia (OR: 1.88; p = 0.003), smoking (OR: 1.78; p = 0.003), obesity (OR: 1.98; p = 0.034) and underweight (OR: 1.49; p = 0.023).25376847
Dyslipidemias, ObesityDeregulated Nutrient SensingA lesser degree of concordance was found for dyslipidemia (defined as drug use alone in SHS and FIRE, and ICD-10 code E78 in MEDSTAT), and for obesity (defined as BMI >= 30 kg/m(2) derived from self-reported height and weight in SHS, from measured height and weight or diagnosis of obesity in FIRE, and ICD-10 code E66 as secondary diagnosis in MEDSTAT).25377723
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingMEDSTAT performed well for clearly defined diagnoses (diabetes, hypertension), but underrepresented systematically more symptomatic conditions (dyslipidemia, obesity).25377723
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingBody weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis.25378371
Diabetes Mellitus, Insulin-Dependent, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Deregulated Nutrient SensingTo determine whether arterial elasticity differs between obese adolescents with clinical insulin resistance (IR), type 1 diabetes (T1D) and healthy non-obese controls.25381349
Sepsis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSepsis and type 2 diabetes exhibit insulin resistance as a common phenotype.25382802
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn type 2 diabetes we and others have recently provided evidence that alterations of the proinflammatory wingless-related integration site (wnt)-5a/anti-inflammatory secreted frizzled-related protein (sFRP)-5 system are involved in the pathogenesis of insulin resistance.25382802
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum aryl hydrocarbon receptor ligand activity is associated with insulin resistance and resulting type 2 diabetes.25385058
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals.25387258
Prediabetes syndrome, Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between insulin resistance and b-cell dysfunction in subphenotypes of prediabetes and type 2 diabetes.25387263
Proteinuria, IGA Glomerulonephritis, Dyslipidemias, Renal glomerular disease, Arteriolosclerosis, Simultaneous, Hyperuricemia, Hypertension, CTCAEDeregulated Nutrient SensingThe characteristics of IgAN in advanced-age were lower renal function, high levels of proteinuria, severe interstitial change, and arteriolosclerosis caused by glomerulopathy and concomitant diseases, such as hypertension, dyslipidemia, and hyperuricemia.25388352
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension, diabetes, dyslipidaemia, and major cardiovascular events (MACE) were more frequent in this group (P < 0.0001), but not tobacco (P < 0.0001).25389080
Psoriasis, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingFrequencies of comorbidities were not statically different but patients with 'early' onset psoriasis have a tendency (P < 0.5) to have higher frequencies of obesity, diabetes, dyslipidaemia, hypertension and MACE.25389080
Parkinson Disease, Inflammation, Muscular AtrophyDeregulated Nutrient SensingIn rodent models of systemic inflammation, Parkinson's disease, or aging-related muscular atrophy, S-nitrosylation of SIRT1 correlated with increased acetylation of p53 and p65 and activation of p53 and NF-kB target genes, suggesting that S-nitrosylation of SIRT1 may represent a proinflammatory switch common to many diseases and aging.25389371
Slow shallow breathingDeregulated Nutrient SensingCompared with baseline data, the postoperative anthropometric characteristics, blood measurements, and sleep recording data, such as weight, apnea hypopnea index (AHI), and insulin resistance index, differed significantly (p < 0.001).25392079
Inflammation, HypertrophyDeregulated Nutrient SensingIn summary, we show that adipocyte hypertrophy is linked to increased inflammation in AT in obese children, thereby providing evidence that obesity-associated AT dysfunction develops in early childhood and is related to insulin resistance.25392242
Prediabetes syndrome, Glaucoma, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDiabetes may affect vascular autoregulation of the retina and optic nerve and may be associated with an increased risk of glaucoma,but the association of prediabetes, insulin resistance, markers of glucose metabolismwith glaucoma has not beenevaluated in general population samples.25393836
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, diabetes mellitus, family history of coronary disease and dyslipidemia represented independent risk factors for acute myocardial infarction.25393858
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingIt was found that more than one-third of the patients had obesity and diabetes, while 10% suffered from dyslipidemia.25394461
Dyslipidemias, Overweight, Hyperuricemia, PrehypertensionDeregulated Nutrient SensingThe average age, proportion of male sex, overweight, impaired fasting glucose (IFG), dyslipidaemia and hyperuricaemia were significantly higher in the prehypertension group than in the optimal BP group (all p <0.05).25394820
Dyslipidemias, Overweight, PrehypertensionDeregulated Nutrient SensingCompared with low-range prehypertension, the proportions of overweight, dyslipidaemia and IFG were higher in the high-range prehypertension group (all p<0.05).25394820
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingEctopic hepatic lipid accumulation is closely related to the development of insulin resistance, which is regarded as one of the most significant risk factors of non-alcoholic fatty liver disease (NAFLD).25399407
Atrial Fibrillation, Dyslipidemias, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingAmong PC patients, IS (n = 190) associated with younger age, prior atrial fibrillation (AF) in 25% and dyslipidemia in ~40%.25402973
Atrial Fibrillation, DyslipidemiasDeregulated Nutrient SensingDespite being of typical age for multiple cardiovascular conditions the PC-ICH patients less often have a previous history of AF or dyslipidemia than IS patients do.25402973
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingTo determine the clinical significance of silent mating type information regulation 2 homolog 1 (SIRT1) expression in Hepatocellular Carcinoma (HCC) and its association with P53 and Yes-associated protein 2 (YAP2) expression.25404446
FAM126A geneDeregulated Nutrient SensingTissue microarray technique and immunohistochemistry were conducted to detect the expression of SIRT1, P53 and YAP2 proteins in 300 self-paired HCC samples.25404446
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingBy tissue microarray technique and immunohistochemistry on 300 self-paired HCC samples, it was found that SIRT1, P53 and YAP2 were significantly overexpressed in HCC tumor tissues compared with adjacent non-tumor tissues.25404446
NeoplasmsDeregulated Nutrient SensingMultivariate analysis showed nuclear SIRT1 and P53 overexpression as independent tumor promoters while cytoplasmic SIRT1 overexpression as an independent tumor suppressor.25404446
FAM126A geneDeregulated Nutrient SensingSIRT1 was overexpressed in HCC and the expression was positively related to P53 and YAP2 expression.25404446
Neoplasms, FAM126A geneDeregulated Nutrient SensingAs the nuclear SIRT1 functions as a tumor promoter and cytoplasmic SIRT1 functions as a tumor suppressor, the role of SIRT1 in HCC should be reconsidered.25404446
Gestational DiabetesDeregulated Nutrient SensingHigh calorie intake is associated with worsening insulin resistance and b-cell function in Hispanic women after gestational diabetes mellitus.25404660
Dyslipidemias, Feeding behaviorsDeregulated Nutrient SensingComorbidities were prevalent, particularly dyslipidemia and problematic eating behaviors.25404751
Dyslipidemias, Obesity, Visceral, Somatotropin deficiencyDeregulated Nutrient SensingAlthough GHDA was associated with the development of visceral obesity and dyslipidemia, these adverse cardiovascular risk factors did not determine a higher prevalence of the MS in Bulgarian GHD patients compared to control subjects.25412168
Liver damage, Fatty Liver DiseaseDeregulated Nutrient SensingOrally administered anti-CD3 antibodies are biologically active in the gut through induction of regulatory T cells, exert an immune-modulatory effect, and alleviate insulin resistance and liver damage in patients with NASH.25412903
ObesityDeregulated Nutrient SensingCharacterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance.25413012
OverweightDeregulated Nutrient SensingCirculating betatrophin levels were increased significantly in obese children and adolescents with insulin resistance (365.77 +- 30.86 pg/mL) compared with overweight or obese subjects without insulin resistance (274.25 +- 26.52 pg/mL; p < 0.05).25413012
Fatty degeneration, Zinc deficiencyDeregulated Nutrient SensingExacerbation of insulin resistance and hepatic steatosis deriving from zinc deficiency in patients with HCV-related chronic liver disease.25413880
deficiency aspectsDeregulated Nutrient SensingTherefore, Zn deficiency resulted in insulin resistance through iron overload.25413880
SteatohepatitisDeregulated Nutrient SensingThese data suggest that, in patients with CLD-C, Zn deficiency promotes insulin resistance by exacerbating iron overload in the liver and induces hepatic steatosis by facilitating lipid peroxidation.25413880
ARCN1 gene, Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingThe effects of Non-invasive Ventilation (NIV) on Insulin Resistance (IR) in stable Chronic Obstructive Pulmonary Disease (COPD) patients have not been fully explored.25415619
Weight Gain, Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and dyslipidemia are common problems in this area and we should note to screen cardiometabolic risk factors in addition of obesity, especially in children with rapid weight gain.25415816
Gestational DiabetesDeregulated Nutrient SensingPlasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes.25419905
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion.25420343
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn the presence of insulin-resistance conditions, such as type 2 diabetes mellitus, this mechanism is altered and the glycation of cytoplasmic as well as mitochondrial proteins may plausibly appear.25420343
Breast CarcinomaDeregulated Nutrient SensingCorrelation and prognostic value of SIRT1 and Notch1 signaling in breast cancer.25420528
Breast Carcinoma, Malignant NeoplasmsDeregulated Nutrient SensingSIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined.25420528
Breast CarcinomaDeregulated Nutrient SensingThe purpose of this study was to assess the possible prognostic value of SIRT1, N1IC, and Snail expression in breast cancer patients.25420528
Breast CarcinomaDeregulated Nutrient SensingImmunohistochemistry was performed to examine the expression of SIRT1, N1IC, and Snail, and the combined expression of SIRT1 and N1IC, using tissue microarrays containing breast cancer tissue and matched adjacent normal breast tissue from 150 breast cancer patients.25420528
Breast CarcinomaDeregulated Nutrient SensingSIRT1, N1IC, and Snail were all found to be highly expressed and an inverse correlation between SIRT1 and N1IC in breast cancer tissue.25420528
Breast CarcinomaDeregulated Nutrient SensingThese results suggest that low expression of SIRT1 or the combined low expression of SIRT1 and high expression of N1IC could be used as indicators of poor prognosis, and may represent novel therapeutic targets in breast cancer.25420528
DyslipidemiasDeregulated Nutrient SensingPatients carrying the E2 allele displayed protective lipid profile, while those carrying E4 appeared to be at higher risk of dyslipidemia.25420659
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingMetabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study.25423564
AtherosclerosisDeregulated Nutrient SensingA multiethnic cohort from the Insulin Resistance Atherosclerosis Study.25423564
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis pattern was associated with conversion to T2D, remaining significant when accounting for b-cell function, emphasizing a link between this metabolic profile and insulin resistance.25423564
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese results demonstrate a consistent metabolic signature associated with insulin resistance and conversion to T2D, providing potential insight into underlying mechanisms of disease pathogenesis.25423564
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Obesity, HyperandrogenismDeregulated Nutrient SensingPolycystic Ovary Syndrome (PCOS) is tightly associated with insulin resistance and obesity and characterized by hyperandrogenism, chronic oligo-anovulation and polycystic ovarian morphology when fully expressed.25424668
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingCirculating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes.25425220
LipolysisDeregulated Nutrient SensingThese FA patterns are supposed to be connected with the progression and/or impaired biochemical measures of MS (lipolysis, oxidative stress, dysglycidemia, and insulin resistance).25428743
Sleep Apnea, CTCAE, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingSleep apnea (OR, 3.8; P <= .03) and arterial hypertension (OR, 4.1; P <= .05) were associated with stenosis severity, whereas diabetes, smoking, dyslipidemia, BMI, age, and sex were not.25429400
Abnormal renal functionDeregulated Nutrient SensingKidney dysfunction induces insulin resistance, but it is unknown if b cell function is affected.25429626
Nonalcoholic Steatohepatitis, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic steatohepatitis (NASH) is associated with dyslipidemia and cardiovascular disease (CVD).25429853
Dyslipidemias, Fatty Liver DiseaseDeregulated Nutrient SensingTo determine the relationship between resolution of NASH and dyslipidemia.25429853
Dyslipidemias, Adenoma of large intestineDeregulated Nutrient SensingPrevious studies on the association between dyslipidemia and the presence of colorectal adenoma showed conflicting results, and were limited due to small sample sizes, inconsistent definitions of dyslipidemia, or a lack of data on full lipid profiles.25436347
Dyslipidemias, Adenoma of large intestineDeregulated Nutrient SensingThe aim of this study was to determine the association between colorectal adenomas and dyslipidemia according to the definition by the National Cholesterol Education Program- Adult Treatment Panel III.25436347
Adenoma, Dyslipidemias, Adenoma of large intestineDeregulated Nutrient SensingSerum dyslipidemia profiles were compared between the adenoma group and the control group, and multivariate analysis was performed to identify independent predictors of the presence of colorectal adenomas.25436347
Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity is a major risk factor for insulin resistance and type-2 diabetes.25437865
ObesityDeregulated Nutrient SensingA chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis.25437865
ObesityDeregulated Nutrient SensingResults from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induced-insulin resistance.25437865
Inflammation, ObesityDeregulated Nutrient SensingTaken together, these results confirm the previously established notion of chronic low grade inflammation in obesity and further suggests a role for the LT pathway in obesity-associated development of insulin resistance in humans.25437865
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAs risk factors, hypertension, diabetes mellitus, and dyslipidemia were much more common in patients with NSTEMI than STEMI.25438907
Obesity, AbdominalDeregulated Nutrient SensingHigh FFL levels were associated with abdominal obesity, insulin resistance, and a lower live birth rate after IVF-ICSI.25439803
ObesityDeregulated Nutrient SensingFurther investigations are warranted to define the precise roles of leptin, obesity, and insulin resistance on IVF-ICSI outcomes.25439803
Cockayne SyndromeDeregulated Nutrient SensingA high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.25440059
hepcidin, Obesity, Diabetes MellitusDeregulated Nutrient SensingElevated hsCRP and hepcidin levels, and increased gene expression of TNF-a, IL-6, NF-kB, and TLR-2/4 in patients with diabetes, obesity, or both exacerbate and perpetuate the insulin resistance and inflammatory state.25441587
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingComorbidities included hypertension (91%), dyslipidemia (87%), coronary artery disease (42%), and diabetes mellitus (38%).25441679
Acanthosis NigricansDeregulated Nutrient SensingAcanthosis nigricans in children is often a cutaneous marker of insulin resistance.25442473
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSpanish Interdisciplinary Committee for Cardiovascular Disease Prevention and the Spanish Society of Cardiology position statement on dyslipidemia management.25443815
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe Spanish Interdisciplinary Committee for Cardiovascular Disease Prevention and the Spanish Society of Cardiology reviewed this guideline and compared it with current European guidelines on cardiovascular prevention and dyslipidemia management.25443815
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient Sensing[Spanish Interdisciplinary Committee for Cardiovascular Disease Prevention and the Spanish Society of Cardiology position statement on dyslipidemia management.25444651
Structure of beta Cell of isletDeregulated Nutrient SensingTo identify any changes in intermediate points after a 2-hour oral glucose tolerance test (OGTT), pancreatic b-cell dysfunction, and insulin resistance in cystic fibrosis-related diabetes.25444978
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingScreening attenders had higher rates of newly diagnosed hypertension, diabetes mellitus, and dyslipidemia, lower inpatient days of stay and cost, and lower outpatient cost compared to non-attenders.25445334
Calcification of coronary artery, Diabetes MellitusDeregulated Nutrient SensingRelationship of glycated hemoglobin A1c, coronary artery calcification and insulin resistance in males without diabetes.25446621
SLC25A20 geneDeregulated Nutrient SensingStratification by HbA1c showed a significant association between CAC and insulin resistance only in the first (OR 1.67) and fourth (OR 1.33) HbA1c quartile.25446621
SLC25A20 geneDeregulated Nutrient SensingAfter adjustment for CV risk factors, insulin resistance remained an independent predictor of CAC only in the first HbA1c quartile.25446621
SLC25A20 geneDeregulated Nutrient SensingOur study demonstrated that not only glucose status represented by HbA1c but also insulin resistance might be associated with CAC in non-diabetic Korean men.25446621
SLC25A20 geneDeregulated Nutrient SensingThe magnitude of association of CAC with insulin resistance was greater in the lowest HbA1c quartile group.25446621
Dyslipidemias, diabeticDeregulated Nutrient SensingPersistent lipid abnormalities in statin-treated patients: Portuguese diabetic subpopulation of the Dyslipidaemia International Study (DYSIS).25449144
Cystic FibrosisDeregulated Nutrient SensingThe anti-inflammatory and immunomodulating effect of macrolides did not seem to affect the b cell function or insulin resistance in patients with cystic fibrosis.25450813
AHSG protein, humanDeregulated Nutrient SensingFetuin-A is a circulating glycoprotein capable of inhibiting insulin signaling both in vivo and in vitro and is positively associated with insulin resistance.25450818
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingOsteoprotegerin (OPG) acts as a regulatory molecule with increased levels in the early stages of diabetes and atherosclerosis, and is also associated with insulin resistance.25450818
Increased insulin level, Skeletal muscle structureDeregulated Nutrient SensingIn the present study, we hypothesized that hyperinsulinemia as an early predictor of insulin resistance may be associated with the loss of appendicular skeletal muscle mass (ASM).25453394
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia as an early marker of insulin resistance was associated with the loss of ASM in a cohort study of community-dwelling older men and women subjects without other chronic health conditions.25453394
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a risk factor for cardiovascular disease that has become an increasing public health problem.25453396
DyslipidemiasDeregulated Nutrient SensingDyslipidemia is especially relevant in vulnerable populations such as postmenopausal women.25453396
Depressive disorderDeregulated Nutrient SensingAssociation between insulin resistance and cognition in patients with depressive disorders: exploratory analyses into age-specific effects.25455511
Angina, Unstable, DyslipidemiasDeregulated Nutrient SensingSeventy patients with unstable angina pectoris and untreated dyslipidemia were randomized to either 20 mg/day or 5 mg/day of atorvastatin therapy.25456755
Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient Sensing54.1% of patients had dyslipidemia, 47.5% hypertension, 17.7% diabetes, and 10.8% history of ischemic heart disease.25459384
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingRegarding drugs, despite 55% of hypertensive patients were taking>=2 antihypertensive agents, only 59.9% achieved blood pressure targets; 65.7% of patients with dyslipidemia were taking statins, but only 35.6% attained LDL-cholesterol goals.25459384
Fatty degeneration, Diabetes Mellitus, Hepatobiliary Disorder, Obesity, Liver CirrhosisDeregulated Nutrient SensingMany patients with alcohol-associated cirrhosis also have diabetes, obesity, or insulin resistance-mediated steatosis, but little is known about how these disorders affect the severity of liver disease.25459558
DyslipidemiasDeregulated Nutrient SensingNon-HDL cholesterol (non-HDL-C) has recently been recommended as a first target for dyslipidemia management.25463086
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe have previously reported the combined effect of SNPs perturbing insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on insulin resistance (IR), type 2 diabetes (T2D) and cardiovascular events.25463099
Mortality, PrematureDeregulated Nutrient SensingLeprechaunism, a rare genetic disease resulting from mutations in two alleles of the insulin receptor gene, is characterized by severe insulin resistance, retarded growth and, usually, premature death.25465274
Dyslipidemias, OverweightDeregulated Nutrient SensingThe participants in this study were young; slightly overweight; had normal glucose tolerance; and had lipid values indicating dyslipidemia or close dyslipidemia.25466664
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingElevated plasma asymmetric dimethylarginine (ADMA) levels have been observed in patients with insulin resistance and diabetes, and have been reported to predict adverse cardiovascular events in type 2 diabetic patients.25467091
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE, Kidney FailureDeregulated Nutrient SensingRegarding risk factors, 86% of patients had hypertension, 66% exposure to smoke, 47% diabetes, 65% dyslipidemia, 24% coronary artery disease, 16% renal failure and 60% had family history of cardiovascular disease.25467094
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe value of different insulin resistance indices in assessment of non-alcoholic fatty liver disease in overweight/obese children.25470627
Alzheimers Disease", Mild cognitive disorderDeregulated Nutrient SensingAmnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters.25471189
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMedical histories of hypertension and dyslipidemia were more frequent in the low %VC group than in the normal %VC group in both sexes.25477291
Non-insulin Hypoglycemic, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn total, 70*5% of patients suffered from arterial hypertension, 45*2% were obese, 27*2% had non-insulin dependent diabetes, and 24*4% dyslipidaemia.25483380
AtherosclerosisDeregulated Nutrient SensingARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.25484082
AtherosclerosisDeregulated Nutrient SensingIn line with the above observations, genetic ablation of Arg2 in apoe(-/-) mice reduced RPS6KB1, enhanced PRKAA signaling and endothelial autophagy in aortas, which was associated with reduced atherosclerosis lesion formation.25484082
Inflammation, Blood Vessel, Hypoxemia, Pre-EclampsiaDeregulated Nutrient SensingFaulty placentation manifests in the mother as preeclampsia with vascular damage, enhanced systemic inflammation, and insulin resistance; in the placenta as oxygen and nutrient transfer restriction and oxidative stress; and in the fetus as growth restriction and progressive hypoxemia.25485869
AlbuminuriaDeregulated Nutrient SensingElevated Lp(a) levels have a robust association with mild GFR impairment in type 2 diabetics independent of race, insulin resistance, and albuminuria.25490096
Pancreatic hyperplasiaDeregulated Nutrient SensingIn contrast, PGKmutBP3 mice developed insulin resistance with age in association with pancreatic b-cell hyperplasia, impaired expression of uncoupling protein-1 in BAT, and increased adiposity.25490144
Renal Insufficiency, Hyperlipidemia, Glucose Intolerance (disease), HypothyroidismDeregulated Nutrient SensingHypothyroidism caused impaired renal function, glucose intolerance, hyperlipidemia, and reduction in serum phosphate.25491211
Thyroid Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and serum mineral profiles in patients with thyroid disorders.25491211
Kidney Failure, ChronicDeregulated Nutrient SensingDyslipidemias may account for the excess of cardiovascular mortality in end-stage renal disease (ESRD).25495659
Diabetes MellitusDeregulated Nutrient SensingVitamin D and vitamin K supplementation should be considered prebariatric surgery in patients with diabetes or severe insulin resistance.25496224
DyslipidemiasDeregulated Nutrient SensingHigh prevalence of dyslipidemia and associated risk factors among rural Chinese adults.25496459
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a key independent modifiable risk factor for Cardiovascular Disease, which is a leading contributor to morbidity and mortality in most developed and developing countries.25496459
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingPrevalence of lipid abnormality (including borderline dyslipidemia and dyslipidemia) was 47.8%, 13.8%, 25.7% and 30.7% for TC, HDL-C, LDL-C and TG, respectively.25496459
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingWe also examined various risk factors for dyslipidemia, many of which are modifiable risk factors for Cardiovascular Disease (CVD), to provide a comprehensive view that will help in designing strategies to slow the rapid spread and promote effective measures to treat dyslipidemia.25496459
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingTo evaluate the effects of XZK on lipids in subjects with dyslipidemia but no coronary heart disease.25499939
Dyslipidemias, ObesityDeregulated Nutrient SensingThe SNP rs662 in the paraoxonase 1 gene (PON1 Q192R) has been associated with obesity, dyslipidemia and cardiovascular risk.25500007
DyslipidemiasDeregulated Nutrient SensingPolymorphisms were identified in genes selected for their role in the development of atherogenic dyslipidemia, defined as triglycerides 1.7mmol/L and high-density lipoprotein cholesterol (HDLc) <1.02 in women or 1.28mmol/L in men.25500319
DyslipidemiasDeregulated Nutrient Sensing468 patients were included, 148 of them had a diagnosis of atherogenic dyslipidemia.25500319
Colorectal CarcinomaDeregulated Nutrient SensingHigh levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients.25500546
Malignant NeoplasmsDeregulated Nutrient SensingPrevious studies show that SIRT1 is overexpressed in some cancers and plays an essential role in tumorigenesis.25500546
Colorectal CarcinomaDeregulated Nutrient SensingHowever, the association between SIRT1 and colorectal cancer (CRC) is still unclear.25500546
Colorectal CarcinomaDeregulated Nutrient SensingWe found that many CRC specimens had strong SIRT1 expression, which had an obvious correlation with poor prognosis of CRC patients.25500546
Colorectal CarcinomaDeregulated Nutrient SensingMeanwhile, SIRT1 expression had a co-localization with CD133, a current universal marker to characterize colorectal cancer stem cells (CSCs).25500546
Colorectal CarcinomaDeregulated Nutrient SensingMoreover, SIRT1 deficiency decreased percentage of CD133(+) cells, attenuated the abilities of colony and sphere formation, and inhibited tumorigenicity in vivo in CRC cells.25500546
Colorectal CarcinomaDeregulated Nutrient SensingFurther study demonstrated that the expressions of several stemness-associated genes, including Oct4, Nanog, Cripto, Tert and Lin28, were reduced by SIRT1 knockdown in CRC cells.25500546
Colorectal Carcinoma, NeoplasmsDeregulated Nutrient SensingSIRT1 is a potential independent prognostic factor of CRC patients after tumor resection with curative intent, and will contribute to providing a promising new approach to target at CSCs in CRC treatment.25500546
InflammationDeregulated Nutrient SensingThese results suggest that the effect of losartan on insulin resistance is associated with the reduction of oxidative stress and inflammation in patients with type 2 DKD as well as the activation of insulin signal pathway in insulin-resistance 3T3-L1 adipocytes through modulation of PI3K pathway.25502581
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAlmost all DFS patients had at least one vascular risk factor, with a high rate of arterial hypertension and dyslipidemia.25502582
Primary malignant neoplasmDeregulated Nutrient SensingIn the cancer group, the expression level of SIRT1 was down-regulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001).25503141
Nucleus PulposusDeregulated Nutrient SensingSIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells.25503852
Rheumatoid Arthritis, AtherosclerosisDeregulated Nutrient SensingInsulin resistance in rheumatoid arthritis: disease-related indicators and associations with the presence and progression of subclinical atherosclerosis.25504899
Refractory anemias, Inflammation, Rheumatoid Arthritis, AtherosclerosisDeregulated Nutrient SensingSystemic inflammation and insulin resistance (IR) are linked, yet the determinants of IR and its impact on atherosclerosis in rheumatoid arthritis (RA) are incompletely understood.25504899
Obesity, Abdominal, Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingMetabolic disturbances were found in the majority of the examinees with abdominal obesity and NAFLD; they were concurrent and increased in their rate and degree with the progression of NAFLD, obesity, and insulin resistance.25509888
Dyslipidemias, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, metabolic disturbanceDeregulated Nutrient SensingThe investigation has revealed that NAFLD is associated with cardiometabolic disorders (dyslipidemia, carbohydrate metabolic disturbances, and insulin resistance) increasing in their rate and degree with the progression of NAFLD and the lower adiponectin level reducing as NAFLD worsens.25509888
Increased insulin level, HypothyroidismDeregulated Nutrient SensingThe patients with hypothyroidism were found to have statistically significantly enhanced insulin resistance (IR) and compensatory hyperinsulinemia in the presence of android fat distribution.25509889
DyslipidemiasDeregulated Nutrient SensingThe found atherogenic dyslipidemia manifested itself as an increase in the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and atherogenic index and as a reduction in high-density lipoprotein cholesterol.25509889
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingHypothyroidism is accompanied by the development of atherogenic dyslipidemia.25509889
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMetformin, an insulin-sensitizer, may correct several physiologic abnormalities owing to insulin resistance in patients with type 2 diabetes mellitus (DM).25510597
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAlthough the proportions of male gender, hypertension, and dyslipidemia were higher in AAA patients, such differences were not statistically significant.25510745
Essential Hypertension, Impaired cognitionDeregulated Nutrient SensingInsulin resistance is an important risk factor for cognitive impairment in elderly patients with primary hypertension.25510751
Presenile dementia, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance plays a role in the development of dementia and hypertension.25510751
Hypertensive (finding), Impaired cognitionDeregulated Nutrient SensingInsulin resistance plays an important role in the development of cognitive impairment in primary elderly hypertensive patients.25510751
Breast CarcinomaDeregulated Nutrient SensingUpon confirmatory findings, this might help identify patient subgroups who may best benefit from the use of interventions targeting insulin resistance in well depicted breast cancer scenarios.25510909
Hepatobiliary Disorder, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingData on demographic information, lifestyle, history of diabetes mellitus, hypertension, dyslipidemia and liver disease were collected.25513998
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingObese PCOS patients presented significantly more insulin resistance than nonobese PCOS patients.25514100
Data types - AddressDeregulated Nutrient SensingWM improvement was inversely associated with insulin resistance (r=-0.418, p<0.01), but not with AD biomarkers.25516316
Weight GainDeregulated Nutrient SensingThe instant coffee mix that contains non-dairy creamer and/or sugar still takes up a significant portion of coffee consumption in Korea, which may result in weight gain and insulin resistance, and potential benefits of coffee may be offset.25516328
parathyroid hormone secretionDeregulated Nutrient SensingOral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males.25517289
parathyroid hormone secretionDeregulated Nutrient SensingHowever, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance.25517289
Fatty Liver DiseaseDeregulated Nutrient SensingFatty liver disease, glucose tolerance and insulin resistance in obese adolescents.25522002
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdult studies suggest that intra-hepatic fat predicts 2-h blood glucose levels and type 2 diabetes, and may have a role in the development of insulin resistance.25522002
Cardiovascular DiseasesDeregulated Nutrient SensingEnhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-g, has been related to cardiovascular disease progression and insulin resistance.25524770
Inflammation, ObesityDeregulated Nutrient SensingDiet-induced obesity can induce low-level inflammation and insulin resistance.25526310
Inflammation, Diabetes MellitusDeregulated Nutrient SensingInterleukin-1b (IL-1b) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined.25526310
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur studies identify a regulatory mechanism controlling diet-induced insulin resistance by highlighting a critical role for Pellino3 in regulating IL-1b expression with implications for diseases like type 2 diabetes.25526310
Pancreatitis, DyslipidemiasDeregulated Nutrient SensingThe incidence of chronic pancreatitis (CP) is increasing, and dyslipidemia severely affects the health of middle-aged and elderly people.25526493
Polycystic Ovary SyndromeDeregulated Nutrient SensingSerum sirtuin 1 levels in patients with polycystic ovary syndrome.25526506
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingObjective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS).25526506
Inflammation, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe sirtuin 1 level, which is associated with inflammation, the immune system and insulin metabolism, was higher in the PCOS patients than in the healthy controls.25526506
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingPlasma calprotectin is a potential biomarker of cardiovascular disease (CVD), insulin resistance (IR), and obesity.25527236
Inflammation, Diabetes MellitusDeregulated Nutrient SensingAGEs have been associated with insulin resistance, oxidative stress, and chronic inflammation in patients with diabetes.25527756
Cessation of life, Liver carcinomaDeregulated Nutrient SensingSCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway.25528629
Cessation of life, FAM126A geneDeregulated Nutrient SensingFurthermore, the human HCC cells death triggered by inhibition of SCD1 was partly involved in autophagy-induced apoptosis via AMPK signaling.25528629
FAM126A geneDeregulated Nutrient SensingOur findings reveal a novel role for SCD1 in the regulation of autophagy via AMPK signaling and provide mechanistic input for the clinical exploration that the combination of SCD1 inhibition with autophagy induction may be attractive for the management of HCC.25528629
Bipolar DisorderDeregulated Nutrient SensingInsulin resistance and depressive symptoms in older men: the health in men study.25532417
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is a state of reduced responsiveness of target tissues to normal circulating levels of insulin and predisposes to diabetes in the presence of beta cell dysfunction.25532417
Diabetes Mellitus, Bipolar DisorderDeregulated Nutrient SensingWe conducted this cross-sectional and prospective study in a community representative sample of 3,140 older men free of diabetes to determine if insulin resistance was associated with prevalent and incident depressive symptoms.25532417
Depression, CTCAEDeregulated Nutrient SensingMen with insulin resistance had increased odds of depression cross-sectionally (odds ratio [OR]: 1.61; 95% confidence interval [CI]: 1.08-2.40), although this was not significant after adjustment for possible confounding (OR: 1.32; 95% CI: 0.85-2.03).25532417
Bipolar DisorderDeregulated Nutrient SensingIn the longitudinal analysis, men with insulin resistance were more likely to develop clinically significant depressive symptoms (adjusted risk ratio [RR]: 2.33; 95% CI: 1.17-4.62), and this risk was greatest for men in the highest quartile of insulin resistance compared with those in the lowest quartile (adjusted RR: 2.54; 95% CI: 1.04-6.18).25532417
Bipolar DisorderDeregulated Nutrient SensingOlder men with clinically significant depressive symptoms were more likely to have higher markers of insulin resistance.25532417
Depression, CTCAEDeregulated Nutrient SensingAdditionally, the odds of depression increased with increasing levels of insulin resistance, and insulin resistance increased the risk of developing depression over 5 years later.25532417
Depression, CTCAEDeregulated Nutrient SensingBecause depression is now a leading cause of disability worldwide, addressing the rising challenge of insulin resistance may prove important in improving the future health of our communities.25532417
Increased insulin level, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis drug is widely used in the treatment of type 2 diabetes, where it is often referred to as an 'insulin sensitizer' because it not only lowers blood glucose, but also reduces the hyperinsulinemia associated with insulin resistance.25534180
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingEffects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model.25534414
Heat-Shock Response, Heat-Shock Proteins 70Deregulated Nutrient SensingActivity of AMPK and phospho-AMPK, acetyl coenzyme-A carboxylase (ACC), phospho-ACC and heat shock protein-70 (Hsp70) were also measured using Western blot.25534414
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingInhibition of AMPK may provide a therapeutic strategy for ALS.25534414
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFasting insulin concentrations are increasingly being used as a surrogate for insulin resistance and risk for type 2 diabetes (T2DM), although associations with adult outcomes are unclear.25535261
Leukemia, Myelocytic, AcuteDeregulated Nutrient SensingProteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.25537507
Leukemia, Myelocytic, AcuteDeregulated Nutrient SensingMounting evidence has shed light on the relevance of proteolytic systems (autophagy and ubiquitin-proteasome system, UPS), as well as the AMPK pathway, in AML biology and treatment, but their exact role is still controversial.25537507
Dyslipidemias, Shock, CardiogenicDeregulated Nutrient SensingOn multivariate analysis, dyslipidemia [0.74 (0.58-0.94), p = 0.02], vitamin K antagonists [0.55 (0.44-0.69), p < 0.001], ACEi/ARB + BB + MRA [0.56 (0.32-0.96), p = 0.04], and ACEi/ARB + BB [0.57 (0.45-0.72), p < 0.001] were associated with improved survival, conversely to cardiogenic shock [3.37 (1.90-5.98), p < 0.001], denutrition [1.61 (1.24-2.09), p < 0.001], and age over 90 [1.35 (1.09-1.67), p = 0.01].25537794
Obesity, AbdominalDeregulated Nutrient SensingWe also observed the same pattern using insulin resistance data for categorizing abdominal obesity phenotypes.25540856
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) without insulin resistance: Is it different?25543522
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of insulin resistance [IR].25543522
Degenerative polyarthritis, Dyslipidemias, Heart failure, Sleep Apnea SyndromesDeregulated Nutrient SensingPatient-reported treatments for comorbidities were frequent: high blood pressure, 59.1%; dyslipidaemia, 59.9%; myocardial infarction/angina pectoris, 9.7%; revascularization, 7.8%; heart failure, 7.4%; sleep apnoea, 8.3%; and osteoarthritis, 10.7%.25544682
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingEffective management of care and medication regimens for complex patients remains an unresolved challenge, but these results suggest that medication refill adherence might be improved by minimizing the number of prescribers involved in a patient's care, at least for hypertension and dyslipidemia.25549627
MicroalbuminuriaDeregulated Nutrient SensingThe IL-33 levels showed a serial decline with increasing severity of insulin resistance and microalbuminuria.25550844
Cancer-related fatigueDeregulated Nutrient SensingHigher 25(OH)D and CRF are crucial for reducing insulin resistance regardless of abdominal fat.25551248
Cancer-related fatigueDeregulated Nutrient SensingIn addition, higher 25(OH)D concentration may strengthen the effect of CRF on reducing insulin resistance in middle-aged and elderly Japanese men with high CRF.25551248
Dyslipidemias, Kidney Failure, Malignant Neoplasms, Diabetes MellitusDeregulated Nutrient SensingStatistically significant risk factors associated with an increased risk of malignancy after HTX were older age (P<0.0001), male recipients (P=0.0008), dyslipidemia (P=0.0263), diabetes mellitus (P=0.0003), renal insufficiency (P=0.0247), and >1 treated rejection episode (TRE) in the first year after HTX (P=0.0091).25552900
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOf these patients, 70.1% had hypertension, 47.1% had dyslipidemia, and 36.2% had diabetes mellitus.25553938
Hepatitis B, Chronic, Non-alcoholic Fatty Liver Disease, Fatty degeneration, Hepatitis C, ChronicDeregulated Nutrient SensingPrevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease.25553983
Injury of liver, Fatty degeneration, Complete atrioventricular block, Non-alcoholic Fatty Liver Disease, Carcinogenic Chlorinated HydrocarbonDeregulated Nutrient SensingTo investigate the prevalence and determinants of steatosis and insulin resistance (IR) in CHB and its consequences on liver injury compared with CHC and NAFLD.25553983
Adult disease, Cardiovascular DiseasesDeregulated Nutrient SensingWe analyzed hormone levels of dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-I (IGF-I), which are hypothesized to be two pathways linking early growth with adult diseases (such as type 2 diabetes and cardiovascular disease) via their effects on enhanced insulin resistance.25555552
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingMore than 50% had a history of diabetes, dyslipidaemia or hypertension.25556407
Prostate carcinomaDeregulated Nutrient SensingOrphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes.25557355
Prostate carcinoma, doxorubicin, NeoplasmsDeregulated Nutrient SensingFurthermore, enhancement of TLX activity, by either ectopic expression or ligand stimulation, could potently prevent doxorubicin-induced senescence in prostate cancer cells and also allow prostatic epithelial cells to escape oncogene-induced senescence induced either by activated oncogene H-Ras(G12V) or knockdown of tumour suppressor PTEN, via a mechanism of direct but differential transcriptional regulation of two senescence-associated genes, repression of CDKN1A and transactivation of SIRT1.25557355
ObesityDeregulated Nutrient SensingCannabis use in relation to obesity and insulin resistance in the Inuit population.25557382
ObesityDeregulated Nutrient SensingTo ascertain the relationship between cannabis use, obesity, and insulin resistance.25557382
Colorectal CarcinomaDeregulated Nutrient SensingGiven the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) genes were associated with CRC risk.25557790
Hypertension, CTCAE, Dental Plaque, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA comparison of risk factors in specific subgroups showed that the association of lower HRV with carotid plaque was more prominent in patients with cardiovascular risk factors including male gender, hypertension, dyslipidemia and diabetes mellitus.25558036
Hypertension, CTCAE, Comorbidity, DyslipidemiasDeregulated Nutrient SensingHalf of the population presented simultaneous hypertension, dyslipidemia, and DM comorbidities.25563032
DiseaseDeregulated Nutrient SensingA simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition.25567200
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingFinally, principal component analysis distinguished type 2 diabetic patients with and without atherogenic dyslipidemia (AD) on a second cohort of 307 subjects characterized using the Liposcale test (area under the curve = 0.88) and showed concordant relationships between variables explaining AD.25568061
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of fructosamine to indices of dyslipidemia in older adults with type 2 diabetes.25572758
Dyslipidemias, Blood GlucoseDeregulated Nutrient SensingFructosamine was significantly correlated with measures of dyslipidemia and glycemia both at baseline and over time, and may represent a relatively sensitive and low cost index of short to medium term change in both glycemia and certain lipid profiles.25572758
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn 66 patients, 47% were men, 26% had diabetes, 68% had hypertension and 76% had dyslipidemia.25574858
HypercholesterolemiaDeregulated Nutrient SensingEzetimibe ameliorates atherogenic lipids profiles, insulin resistance and hepatocyte growth factor in obese patients with hypercholesterolemia.25575766
Alzheimers Disease", Hypermetabolism, Impaired cognitionDeregulated Nutrient SensingInsulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to Alzheimer disease.25576061
Atrial Fibrillation by ECG Finding, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingRegarding risk factors for stroke, 260 subjects (81.0%) had hypertension, 249 subjects (77.6%) had dyslipidemia, 102 subjects (31.8%) had diabetes mellitus, 47 subjects (14.6%) had atrial fibrillation, and 98 subjects (30.5%) had chronic kidney disease.25576351
SepsisDeregulated Nutrient SensingThe increase in HMW/total adiponectin ratio with improvement of the clinical condition suggests that HMW adiponectin may have a greater role in the inflammatory process and insulin resistance seen in sepsis.25580089
Klinefelter Syndrome, Cushing Syndrome, Secondary osteoporosis, Endocrine System Diseases, Glucose Intolerance (disease), OsteopeniaDeregulated Nutrient SensingIt is associated with many endocrinopathies including hypogonadotropic hypogonadism, hypercortisolism, and glucose intolerance that may lead to bone loss with secondary osteoporosis.25580607
ObesityDeregulated Nutrient SensingWe previously identified IKK-e and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance.25581158
Hypercholesterolemia, Hypertriglyceridemia, Overweight, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia among overweight and obese children was 50.4% and its pattern was: hypertriglyceridemia 31.9%, low HDL-C 29.7%, high non-HDL-C 15.8%, hypercholesterolemia 11.9%, and elevated LDL-C 10.7%.25581987
Diabetes MellitusDeregulated Nutrient SensingChanges in diastolic function are already present before the onset of diabetes, being mainly associated with the state of insulin resistance.25582424
Vascular Diseases, Metabolic Syndrome X, Migraine Disorders, Cerebrovascular accident, Coronary heart diseaseDeregulated Nutrient SensingMigraine patients present increased risks of vascular diseases such as high blood pressure, insulin resistance, metabolic syndrome, stroke and coronary heart disease.25585507
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP).25587205
Hypertension, CTCAE, Dyslipidemias, HaitiDeregulated Nutrient SensingThese findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients.25587205
RETINOSCHISIS 1, X-LINKED, JUVENILE, Dyslipidemias, OverweightDeregulated Nutrient SensingStudy included 47 overweight and obese men and women with disordered glucoregulation and dyslipidaemia, aged between 45-74, divided into RS and Fibre group.25588971
Impaired cognition, Nerve DegenerationDeregulated Nutrient SensingSIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1b.25589773
Dyslipidemias, Overweight, Cardiovascular DiseasesDeregulated Nutrient SensingOverweight is one of the major public health problems in Brazil; it is associated with dyslipidemia, which is an important risk factor for cardiovascular diseases.25590927
Dyslipidemias, OverweightDeregulated Nutrient SensingThe results indicate an association between dyslipidemia and overweight in the population of the city of Sao Paulo.25590927
DyslipidemiasDeregulated Nutrient SensingThe most prevalent dyslipidemia in this population was low HDL-cholesterol.25590927
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingRisk factors such as hypertension (85.3%) and dyslipidemia (75.9%) were the most prevalent, with 35% of diabetics.25590931
Dyslipidemias, Chronic disease, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOur data confirm the inverse relationship existing between pulmonary function and cardiovascular risk factors, obesity, dyslipidemias and hypertension, all of which are conditions related to chronic diseases.25592046
HyperglycemiaDeregulated Nutrient SensingDPP4 activity is an important predictor of the onset of insulin resistance and hyperglycemia in apparently healthy Chinese.25592717
Hypertensive (finding), Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCompared with men, women were older, had lower body mass index, more likely to be hypertensive, less likely to smoke or drink alcohol, and have diabetes or dyslipidemia (p < 0.0001).25592794
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingAberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis.25592834
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingWe report that abnormal localization of HuR was associated with enhanced AMP-activated protein kinase (AMPK) activity in the motor neurons of ALS patients.25592834
Amyotrophic Lateral SclerosisDeregulated Nutrient SensingThis suggests that aberrant activation of AMPK in motor neurons disrupts the normal distribution of HuR, which might imbalance RNA metabolism and contribute to ALS pathogenesis.25592834
Metabolic Syndrome X, Diabetes Mellitus, Non-Insulin-Dependent, Prostate Cancer Outcomes Study, ETV3 wt Allele, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is associated with an increased risk of insulin resistance (IR), metabolic syndrome (MetS), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM).25595199
ObesityDeregulated Nutrient SensingNicotinamide-N-methyltransferase (NNMT) was recently shown to be upregulated in mouse models of insulin resistance and obesity.25596852
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe have explored the hypothesis that white adipose tissue (WAT) NNMT expression and plasma 1-methylnicotinamide (MNA) concentration are increased in human insulin resistance and type 2 diabetes.25596852
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe demonstrate that WAT NNMT expression is regulated in human insulin resistance and type 2 diabetes and that plasma MNA correlates with increased tissue NNMT expression and the degree of insulin resistance, making it a potential biomarker for loss of insulin sensitivity.25596852
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, dyslipidemia and smoking were seen in 11 (44%), 10 (40%) and 4 (16%) patients respectively.25604361
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance of protein metabolism occurs in obesity and type 2 diabetes (T2D).25604923
Complication Aspects, Cushing Syndrome, Dyslipidemias, Obesity, Saint Helena Islands, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSubclinical hypercortisolism (SH) has been associated with metabolic complications such as type 2 diabetes mellitus, obesity and dyslipidemia.25608646
Dyslipidemias, Immunoglobulin M, Saint Helena Islands, Adrenal incidentaloma, Hypertension, CTCAEDeregulated Nutrient SensingIn 338 patients with adrenal incidentaloma, the presence of SH, hypertension, dyslipidemia and IGM was evaluated.25608646
DyslipidemiasDeregulated Nutrient SensingThe IGM+SH+ patients had a higher prevalence of dyslipidemia (57.9%) than IGM-SH+ ones (29.1%, P < 0.01).25608646
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe IGM+SH- patients showed an increased prevalence of hypertension (76.6 vs 54.8%, P < 0.01) and dyslipidemia (58.4 vs 23.8%, P < 0.0001) as compared with IGM-SH- patients.25608646
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe clinical evolution was favorable under antiretroviral treatment until 2003 when dyslipidemia and arterial hypertension appeared.25611282
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Peripheral Vascular DiseasesDeregulated Nutrient SensingThey had a lower prevalence of dyslipidemia, diabetes mellitus, coronary artery disease, prior myocardial infarction, and peripheral vascular disease (P < 0.001 for all).25611362
Cessation of life, Cyclophosphamide/Vincristine/Dacarbazine Regimen, arginineDeregulated Nutrient SensingWe investigated non-GFR-related associations between eGFR and two types of nontraditional risk factors for CVD and death: L-arginine/dimethylarginine metabolism and insulin resistance.25612475
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCompared with patients without diabetes, patients with diabetes were more likely to have mixed dyslipidemia.25612824
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingAlthough international guidelines highly recommend intensive lipid modulation in patients with coronary artery disease, persistent dyslipidemia is still prevalent among these patients in China, even with statin treatment.25612824
TriglyceridesDeregulated Nutrient SensingCardiometabolic abnormality was defined as the presence of at least two of the following: high blood pressure, high triglycerides, reduced high density lipoprotein cholesterol, high insulin resistance values, and elevated C-reactive protein and glucose.25618563
SteatohepatitisDeregulated Nutrient SensingOur results showed that BPA-treated rabbits showed insulin resistance, prominent adipose accumulation and hepatic steatosis.25619500
Increased insulin level, Cardiovascular DiseasesDeregulated Nutrient SensingOur results show that smokers have a high risk to developing an insulin resistance and hyperinsulinemia, compared with a matched group of non-smokers, and may help to explain the high risk of cardiovascular diseases in smokers.25620470
Renal Insufficiency, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingStatin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis.25620655
Smoking BehaviorsDeregulated Nutrient SensingAfter adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance.25622280
Diabetes MellitusDeregulated Nutrient SensingThere is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM).25623782
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe risk factors considered were diabetes mellitus, impaired glucose tolerance, impaired fasting glucose, body mass index, dyslipidemia, and arterial hypertension.25624725
Hypertensive (finding), Dyslipidemias, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingHypertensive patients were older and had a higher prevalence of major risk factors, including smoking, obesity, dyslipidemia, and family history of cardiovascular disease, as well as comorbidities, than did normotensive subjects (P < 0.001 for all comparisons).25626397
Dyslipidemias, ETV3 wt AlleleDeregulated Nutrient SensingThe prevalence of MetS increased with higher QTSH within the euthyroid range, mostly by an increase in the dyslipidemia.25627048
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingWhile both pharmacological and genetic suppression of autophagy or inhibition of AMPK phosphorylation sensitized the NSCLC cells to radiation alone, inhibition of the cytostatic autophagy induced by the combination treatment reversed sensitization.25629933
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingTaken together, these studies have identified a unique cytostatic function of autophagy that appears to be mediated by VDR, TP53, and possibly AMPK in the promotion of an enhanced response to radiation by 1,25-D3 and EB 1089 in NSCLC.25629933
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThis ratio was maintained after adjusting for age, sex, hypertension, dyslipidaemia, cardioembolic focus, smoking, diabetes, other cardiovascular diseases, C-reactive protein, and leukocyte count (OR 2.6, 95% CI 1.3 to 5.3).25630457
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingInteresting epidemiological evidence suggests associations between Ps and dyslipidemia (DL), a well-established risk factor for cardiovascular disease.25634083
Arterial Stiffness, Hyperglycemia, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe non-hemodynamic cluster of risk markers and predictors of arterial stiffness in a middle-aged population includes abdominal obesity, hyperglycemia, and dyslipidemia, but not smoking and low-density lipoprotein cholesterol.25634451
Peripheral Vascular Diseases, Carotid Stenosis, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingCoronary artery disease/peripheral vascular disease (CAD/PVD) (p=0.03), dyslipidemia (p=0.02), CKD (p=0.01), and contralateral internal carotid artery stenosis (p=0.02) were non-modifiable risk factors for mRS increase.25635402
TG geneDeregulated Nutrient SensingTo explore the association of lipid ratios and triglyceride (TG) with insulin resistance (IR) in a Chinese population.25635876
ETV3 wt AlleleDeregulated Nutrient SensingIn men, lower T levels, but not E2, are linked with an increased risk of developing MetS, independent of SHBG, BMI or insulin resistance.25636052
Polycystic Ovary Syndrome, HyperandrogenismDeregulated Nutrient SensingInsulin resistance and hyperandrogenism have no substantive association with birth weight in adolescents with polycystic ovary syndrome.25637475
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThe birth weights of adolescents with PCOS as well as those with hyperinsulinemic or insulin resistance were similar to those of the control group.25637475
Prostate Cancer Outcomes Study, HyperandrogenismDeregulated Nutrient SensingLow birth weight may influence the appearance of hyperandrogenism and insulin resistance in a portion of adolescents with PCOS, but only 9% of the adolescents with PCOS in this study were SGA.25637475
diabeticDeregulated Nutrient SensingCirculating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients.25641023
Diabetes MellitusDeregulated Nutrient SensingThere is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes.25644349
millicurie, Data types - AddressDeregulated Nutrient SensingBoth AD and MCI subjects showed increased, insulin receptor substrate 1, a candidate biomarker of brain insulin resistance, and GSK-3b, a kinase targeting tau phosphorylation.25645581
Data types - AddressDeregulated Nutrient SensingThe results hint at a link between Ab and the PI3K/Akt/mTOR axis and provide further insights into the relationship between AD pathology and insulin resistance.25645581
Inflammation, Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevious studies reported beneficial effects of cocoa or chocolate on insulin resistance, oxidative stress, and inflammation, which are important risk factors of type 2 diabetes mellitus (DM).25646334
AtherosclerosisDeregulated Nutrient SensingVisceral fat contributes to insulin resistance and atherosclerosis.25648643
Blood GlucoseDeregulated Nutrient SensingThe effect of this treatment on glycemia, insulin secretion and insulin resistance was investigated.25649338
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population.25649924
Increased insulin level, Prediabetes syndromeDeregulated Nutrient SensingMoreover, the risks for prevalent prediabetes, insulin resistance, and hyperinsulinemia were also decreased from the lowest to the top quartile.25649924
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAccording to the present study, one session of aerobic exercise for middle-aged men with T2D leads to increased IGF-1 and IGFBP-3, and to decreased fasting glucose and insulin resistance.25650732
ObesityDeregulated Nutrient SensingIn addition, it has been reported that black soybean (BS) seed coat may ameliorate obesity and insulin resistance.25651043
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes, hypertension and dyslipidemia was determined at baseline interview.25655678
Dyslipidemias, Kidney FailureDeregulated Nutrient SensingAmong diabetics, higher NLR tertile values were related to ageing (P<0.001), dyslipidaemia (P<0.001), renal failure (P<0.001), body mass index (P<0.001), previous percutaneous coronary revascularization (P=0.004) and cerebrovascular events (P=0.003), acute presentation (P<0.001), treatment at admission with beta-blockers/statins/ASA (all P<0.001), diuretics (P=0.01) or clopidogrel (P=0.04), platelet count (P=0.03), white blood cell count, creatinine, glycaemia and C-reactive protein (P<0.001), and inversely related to haemoglobin, triglyceride levels (P<0.001) and smoking (P=0.03).25656745
SepsisDeregulated Nutrient SensingSirt1 restrains lung inflammasome activation in a murine model of sepsis.25659903
InflammatoryDeregulated Nutrient SensingOur results demonstrated that Sirt1 deficiency led to severe lung inflammatory injury.25659903
lung inductionDeregulated Nutrient SensingAggravated inflammasome activation in Sirt1(-/-) mice was associated with the increased production of lung proinflammatory mediators, including ICAM-1 and high-mobility group box 1, and further disruption of tight junctions and adherens junctions, as demonstrated by dramatic reduction of lung claudin-1 and vascular endothelial-cadherin expression, which was associated with the upregulation of matrix metallopeptidase 9 expression.25659903
Sepsis, PneumonitisDeregulated Nutrient SensingIn summary, our results suggest that Sirt1 suppresses acute lung inflammation during sepsis by controlling inflammasome activation pathway.25659903
CataractDeregulated Nutrient SensingAcetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract.25660075
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingToday, the frequency of dyslipidemia, hypertension and diabetes mellitus has increased, while smoking has decreased.25660087
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension prevalence was 62.3%, for diabetes mellitus it was 48.8%, for smoking it was 18.8% and for dyslipidemia it was 48.8%.25660087
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, DecadeDeregulated Nutrient SensingWe observed an increase in prevalence for diabetes mellitus and dyslipidemia in each cohort according to birth decade, while there was a reduction in prevalence for hypertension in the same decades.25660087
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingStudies were conducted in 28 patients with type 2 diabetes mellitus complicated with dyslipidemia.25660177
DyslipidemiasDeregulated Nutrient SensingA double-blind, randomized, placebo-controlled parallel-group trial (the DALI study group) on 217 patients with T2DM and dyslipidemia was performed.25662039
Coronary heart diseaseDeregulated Nutrient SensingGiven the many syndromes associated with insulin resistance, including T2DM and coronary heart disease, an elevated TG/HDL-C ratio supports more aggressive efforts to enhance insulin sensitivity.25667373
Metabolic DiseasesDeregulated Nutrient SensingRecent studies suggest the potential involvement of environmental chemicals in insulin resistance (IR) that plays a core role in the development of metabolic diseases.25669219
ObesityDeregulated Nutrient SensingVisfatin/Nampt and SIRT1: Roles in Postterm Delivery in Pregnancies Associated With Obesity.25670718
ObesityDeregulated Nutrient SensingThus, higher visfatin/Nampt may prevent a labor-associated decrease in SIRT1 leading to postterm delivery in obesity.25670718
AtherosclerosisDeregulated Nutrient SensingComparison between insulin resistance indices and carotid and femoral atherosclerosis: a cross-sectional population study.25673308
AtherosclerosisDeregulated Nutrient SensingThe aim of this study was to investigate the association between commonly used insulin resistance (IR) indices and the presence and extent of carotid and femoral atherosclerosis in a general population setting.25673308
Migraine Disorders, DyslipidemiasDeregulated Nutrient SensingIn the opposite direction, a positive association between migraine headaches (definite, probable and overall) and dyslipidemia (overall migraine OR, 1.25; 95% CI, 1.13-1.38) was observed only for women, but not for men.25673421
Peripheral T-Cell LymphomaDeregulated Nutrient SensingMorphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options.25674239
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingApproximately 6% were women, 21% were highly disabled from a military service-connected condition, 46% had hypertension, 38% dyslipidemia, and 18% diabetes.25674731
deficiency aspectsDeregulated Nutrient SensingBecause of the severity of the insulin resistance combined with features of insulin deficiency, type B insulin resistance was suspected.25675382
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe major modifiable risk factors are smoking, hypertension, dyslipidaemia, diabetes, and obesity.25675643
Kidney Failure, Diabetes MellitusDeregulated Nutrient SensingTwo major causes of diabetes are insulin resistance and insulin insufficiency.25676679
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance is considered a pathophysiological mechanism of nonalcoholic fatty liver disease (NAFLD).25677815
Increase in blood pressure, Dyslipidemias, Retinal Diseases, Aortic StiffnessDeregulated Nutrient SensingOther independent correlates of progression in aortic stiffness were increases in systolic blood pressure and heart rate between the two cf-PWV measurements, older age, female sex, and presence of dyslipidemia and retinopathy.25678104
Acute leukemia, Dyslipidemias, leukemiaDeregulated Nutrient SensingThese findings may help in outlining the prevalence and types of dyslipidemia in leukemia patients that may emerge as diagnostic/prognostic factors for the management of acute leukemia.25680744
leukemiaDeregulated Nutrient SensingIn addition to comparing the absolute values of plasma lipids in leukemia and control groups we also compared and observed significant differences in prevalence of various isolated- and mixed-dyslipidemias in these groups.25680744
Fibrosis Assessment, Obesity, Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance, obesity, and the presence of either of 2 minor alleles in the PNPLA3 gene were significantly associated with increased risk of NASH and fibrosis.25681381
TG gene, Increased insulin levelDeregulated Nutrient SensingDespite similar fasting glucose and HbA1c concentrations, patients with elevated TG concentrations displayed markers of increased risk of T2DM (insulin resistance and compensatory hyperinsulinemia), more adverse lipid/lipoprotein profiles, and increased prevalence of abnormal hs-CRP values.25682039
Obesity, AbdominalDeregulated Nutrient SensingOdds of overweight/obesity, abdominal obesity and insulin resistance were greater among higher SES.25691273
Obesity, AbdominalDeregulated Nutrient SensingCompared with the lowest SES stratum, children in the highest SES had higher odds of overweight/obesity (OR=3.25, 95% CI 1.89 to 5.57), abdominal obesity (OR=2.74, 95% CI 1.41 to 5.31) and insulin resistance (OR=2.60, 95% CI 1.81 to 3.71).25691273
Hypertriglyceridemia, Dyslipidemias, ObesityDeregulated Nutrient SensingIn Colombian children, SES is directly associated with obesity and insulin resistance, but inversely associated with dyslipidaemia (hypertriglyceridaemia and low HDL cholesterol).25691273
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingTo analyse the treatment and control of dyslipidaemia in patients at high and very high cardiovascular risk being treated for the primary prevention of cardiovascular disease (CVD) in Europe.25692692
Cholangiocarcinoma, Liver carcinomaDeregulated Nutrient SensingDifferential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver.25696003
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingGene expression and deacetylase activity of the class III histone deacetylase SIRT1 are up-regulated in cancer cells due to oncogene overexpression or loss of function of tumor suppressor genes.25696003
Neoplasms, Malignant NeoplasmsDeregulated Nutrient SensingSIRT1 may play a critical role in tumor initiation, progression, and drug resistance by blocking senescence and apoptosis, and promoting cell growth and angiogenesis, but pleiotropic effects (synchronous or metachronous anti-proliferation and anti-apoptotic mechanisms) have been suggested in some cancers.25696003
FBN2 wt Allele, FAM126A geneDeregulated Nutrient SensingWestern blot analysis (WBA) was carried out for expression of SIRT1 in three CCA cell lines, one HCC cell line, and one cell line of Papova-immortalized normal hepatocytes.25696003
FBN2 wt Allele, FAM126A geneDeregulated Nutrient SensingAn expression of SIRT1 was found in 11 of 16 (68.75%) HCC and in 5 of 14 (35.71%) CCA.25696003
FAM126A geneDeregulated Nutrient SensingWBA showed expression of SIRT1 in all cell lines studied, although a stronger signal was seen in the HCC cell line.25696003
FBN2 wt Allele, FAM126A geneDeregulated Nutrient SensingSirtuin 1 is a phylogenetically-conserved family of deacetylases and our data seem to indicate that (1) pleiotropic effects may be present in hepatic epithelial malignancies, and (2) there is no specificity of SIRT1 for either HCC or CCA.25696003
Dyslipidemias, Hypomagnesemia, Chronic Kidney DiseasesDeregulated Nutrient SensingHypomagnesemia and atherogenic dyslipidemia in chronic kidney disease: surrogate markers for increased cardiovascular risk.25697595
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingWe also observed a significant correlation between the lowered serum magnesium concentrations and atherogenic dyslipidemia, suggesting a link to increased cardiovascular risk in CKD patients.25697595
Dyslipidemias, Hypomagnesemia, Chronic Kidney DiseasesDeregulated Nutrient SensingOur results suggest a strong association of hypomagnesemia and atherogenic dyslipidemia in patients with CKD.25697595
Breast CarcinomaDeregulated Nutrient SensingThe mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways.25701120
Primary malignant neoplasmDeregulated Nutrient SensingThe mammalian target of rapamycin complex 1 (mTORC1) is a downstream of the PI3K/Akt pathway which affects cancer development.25701120
Breast CarcinomaDeregulated Nutrient SensingThis study aims to investigate the expression of mTORC1 in breast cancer (BC) and correlate it with key clinicopathological and molecular features of BC especially to proteins related to oestrogen receptor (ER) and HER2 pathways in different BC classes.25701120
NeoplasmsDeregulated Nutrient SensingRPPA indicated that p-mTORC1 expression was mainly related to ER expression and with better outcome in the Akt positive tumours.25701120
Diabetes MellitusDeregulated Nutrient SensingTaken together, we concluded that DDAH2/ADMA is involved in the accelerated senescence of EPCs in diabetes, which is associated with the activation of SIRT1.25701782
Tobacco, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe other associated risk factors were sedentariness in 275 cases (44.4%), overweight/obesity in 134 cases (21.6%), dyslipidemia in 121 cases (19.5%), diabetes mellitus in 90 cases (14.5%), and tobacco addiction in 25 cases (4%).25702238
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingAcute ischemic stroke patients with dyslipidemia and AAPs >=4-mm-thick on transesophageal echocardiography (TEE) were enrolled and randomly allocated to either the group treated with 5 mg/day rosuvastatin or the control group.25702618
Fatty Liver DiseaseDeregulated Nutrient SensingHuman liver PPARa gene expression negatively correlates with NASH severity, visceral adiposity and insulin resistance and positively with adiponectin.25703085
Hyperlipidemia, Dyslipidemias, IschemicDeregulated Nutrient SensingAdditional predictors were low body mass index, male gender, ischaemic HF, low total cholesterol, no history of hyperlipidaemia or dyslipidaemia and presence of atrial fibrillation/flutter.25703424
Endometrial CarcinomaDeregulated Nutrient SensingAdiponectin mediates antiproliferative and apoptotic responses in endometrial carcinoma by the AdipoRs/AMPK pathway.25703675
Hypertension, CTCAE, Premature coronary artery atherosclerosis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAmong the 428 patients, 184 (43%) cases had hypertension, 133 (31%) cases were smokers, 103 (24%) cases had dyslipidemia and diabetes mellitus and 08 (2%) cases had history of premature coronary artery disease.25703749
Blood VesselDeregulated Nutrient SensingSince pigment epithelium-derived factor (PEDF), one of the adipocytokines, inhibits the AGEs-induced insulin resistance and vascular damage, it is conceivable that besides AGEs, PEDF might also regulate soluble DPP-4 levels.25705004
Encounter due to puberty, ObesityDeregulated Nutrient SensingThe data showed changes in DEHP metabolites in urine related with obesity, puberty, and presence of insulin resistance.25706863
Lipodystrophy, Metabolic Syndrome XDeregulated Nutrient SensingThis cohort study shows how the synergy between HIV, antiretroviral (ARV) exposure, and westernization of life style in a cohort of HIV-infected patients of sub-Saharan origin leads to a progressive increase in the risk of lipodystrophy, as well as metabolic syndrome and insulin resistance, all associated with increased cardiovascular risk.25707418
Obesity, Diabetes MellitusDeregulated Nutrient SensingAndroid Adiposity and Lack of Moderate and Vigorous Physical Activity Are Associated With Insulin Resistance and Diabetes in Aging Adults.25711528
AlbuminuriaDeregulated Nutrient SensingAfter adjustment for age, gender, race, smoking, blood pressure, insulin resistance, and body mass index, individuals with less liver fat (higher liver CT attenuation) had a lower probability of having albuminuria at Exam 1 (OR per 10 unit increase in attenuation 0.77, 95 % CI 0.61-0.97, P = 0.02).25712234
Inflammation, Primary malignant neoplasm, HypoxiaDeregulated Nutrient SensingExcess visceral adipose tissue may promote cancer development and progression via an obesity-related metabolic derangements, including adipocytokine-related inflammation, insulin resistance, and hypoxia.25712800
DyslipidemiasDeregulated Nutrient SensingNon-traumatic maneuver of left IMA harvest, well-controlled dyslipidemia and avoidance of using composite grafts can be helpful in maintaining the architecture of the grafts.25714207
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe usefulness of a cholesterol absorption inhibitor in Japanese type 2 diabetes patients with dyslipidemia.25714444
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe studied the clinical efficacy of ezetimibe in Japanese patients with type 2 diabetes mellitus complicated by dyslipidemia, in whom increased cholesterol absorption had been reported.25714444
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNinety-six patients with type 2 diabetes complicated by dyslipidemia received ezetimibe at 10 mg/day for 12 weeks.25714444
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIt is suggested that ezetimibe improves the lipid profile in Japanese type 2 diabetes patients with dyslipidemia through the substantial reduction of cholesterol absorption.25714444
ObesityDeregulated Nutrient SensingOxidative stress has been implicated in the pathogenesis of many conditions, including insulin resistance and obesity.25714911
ObesityDeregulated Nutrient SensingCentral obesity was independently associated with oxidative stress even in a population homogeneous for adiposity and cardiometabolic risk, whereas no relationship was observed between oxidative stress and insulin resistance.25714911
IschemicDeregulated Nutrient SensingThe loss of effectiveness of ischaemic preconditioning in protecting old hearts from ischaemia/reperfusion damage is thought to be due to low sirtuin 1 levels in old hearts.25715432
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingIn addition, even in non-overweight/non-obese men, DT was found to be related to dyslipidemia and hyperglycemia, though with marginal significance (P < 0.05).25716056
APP gene, DyslipidemiasDeregulated Nutrient SensingThe aim of the study was to define the role of CIDE-A gene in patients with dyslipidemia and asymptomatic AAA.25720106
Diabetes MellitusDeregulated Nutrient SensingNo relationship was found between osteocalcin and insulin resistance and lipid metabolism in type 2 diabetes.25721846
Fatty Liver, Inflammation, Metabolic Diseases, ObesityDeregulated Nutrient SensingObesity is a major risk factor for many chronic metabolic diseases such as inflammation, insulin resistance (IR) and fatty liver injury.25723054
FTO protein, humanDeregulated Nutrient SensingThese changes contribute to the development of insulin resistance and obesity-associated diseases.25724478
Glucose Intolerance (disease), Autonomic nervous system disordersDeregulated Nutrient SensingIncreased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey.25724570
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingWe aimed to determine the prevalence of, risk factors for and impact of CAND in glucose intolerance and diabetes.25724570
ObesityDeregulated Nutrient SensingObesity in children is now an increasing health risk worldwide in which the insulin-resistance can be present.25726199
Arthropathy, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, DiseaseDeregulated Nutrient SensingAll patients has diseases associated with obesity, the most frequent of which were arterial hypertension (n = 16), arthropathy (n = 11), dyslipidemia (n = 9) and diabetes (n = 7).25726230
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingCurrent recommendations on treatment of dyslipidemia should be applied with caution in the HIV infected population.25727038
Tumor necrosis, ObesityDeregulated Nutrient SensingTumor necrosis factor-a (TNF-a) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention.25729992
Hypercholesterolemia, Dyslipidemias, Chronic diseaseDeregulated Nutrient SensingSimilar to its existing use in the diagnosis of monogenic dyslipidemias such as familial hypercholesterolemia, clinical inquiry regarding family history was identified as an important determinant of eligibility for APOE genotyping performed in the context of chronic disease risk management.25731628
Primary malignant neoplasmDeregulated Nutrient SensingImpaired insulin resistance might precede the clinical detection of this cancer by several years.25734801
Inflammation, ObesityDeregulated Nutrient SensingInflammation but not obesity or insulin resistance is associated with increased plasma fibroblast growth factor 23 concentration in the elderly.25736796
ObesityDeregulated Nutrient SensingBoth forms of FGF23, iPTH and 25-OH-D3 levels were not related to the occurrence of obesity and insulin resistance.25736796
Inflammation, ObesityDeregulated Nutrient SensingIn conclusion, our study shows that increased levels of both circulating Fibroblast growth factor 23 forms in elderly subjects are associated with inflammation but not obesity or insulin resistance per se.25736796
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAdjusted for other risk factors, being male, older age, higher relative socio-economic disadvantage, being born in Asia, lower educational attainment, medical history of hypertension and dyslipidemia, family history of T2DM, overweight/obese, smoking, long sleeping hours, and psychological distress were significantly associated with higher odds of developing T2DM.25737033
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingHowever, the roles of AMPK in the pathogenesis of Alzheimer's disease (AD) are unclear.25737046
Data types - AddressDeregulated Nutrient SensingTaken together, our data showed that AMPK activation inhibits p-tau396 expression in a GSK3b- and PP2A-dependent manner, and suggest that differential regulation of tau phosphorylation in young SAMP8 mice by AMPK plays a compensatory role against accelerated senescence in this AD animal model.25737046
ObesityDeregulated Nutrient SensingMOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.25738459
ObesityDeregulated Nutrient SensingWhen adjusted for age, gender and pubertal development, higher degree of obesity was a strong predictor of MS. Multivariate analysis showed that taller subjects and those with higher degree of insulin resistance were at significantly higher risk of MS, independent of the degree of obesity.25741939
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese data demonstrate that the STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis.25747354
Asthma, Metabolic Syndrome X, MS gene, ObesityDeregulated Nutrient SensingObesity increases both the risk of asthma and asthma severity and is a well-known risk factor for insulin resistance and the metabolic syndrome (MS) in children and adolescents.25748066
ObesityDeregulated Nutrient SensingAsthma and MS synergistically decrease lung function, as do obesity and insulin resistance.25748066
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThe 420 patients in the study had one or more NCDs such as hypertension, type 2 diabetes mellitus, and dyslipidemia.25751416
Dyslipidemias, ciliary vesicle, Diabetes MellitusDeregulated Nutrient SensingWe recorded diabetes mellitus in 136 patients (20.8%), history of CV disease in 213 (32.6%) and dyslipidaemia in 327 (50.1%).25753805
DyslipidemiasDeregulated Nutrient SensingTherefore, the determinants for achieving the LDL-C target needed to be clarified for better healthcare of the patients with dyslipidemia.25756522
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThere is a growing awareness that lifestyle behavior modifications may reduce weight and the atherogenic dyslipidemia associated with obesity and type 2 diabetes mellitus (T2DM).25757855
hypothalamic-pituitary-adrenal axis, Depression, CTCAEDeregulated Nutrient SensingRelationship between hypothalamic-pituitary-adrenal axis dysregulation and insulin resistance in elderly patients with depression.25757913
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFurthermore, insulin resistance and the prevalence of type 2 diabetes are known to increase with aging.25757913
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingTriglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, an indicator of atherogenic dyslipidemia, is a predictor of cardiovascular (CV) outcomes in the general population and has been correlated with atherosclerotic events.25761189
ObesityDeregulated Nutrient SensingThe common variants in the fat mass and obesity-associated (FTO) gene have been associated with obesity and insulin resistance.25761503
Dyslipidemias, Demographics Domain, Myocardial Ischemia, Diabetes MellitusDeregulated Nutrient SensingMarkers of CVD risk in 65 LTRs with no known history of diabetes mellitus (DM), dyslipidemia, or ischemic heart disease were compared to age-, sex-, and body mass index (BMI)-matched controls with no chronic medical disease.25762084
DyslipidemiasDeregulated Nutrient SensingResults highlight that inherited susceptibilities to dyslipidemia may explain at least in part the heterogeneity in the cholesterol-lowering effects of the MedDiet.25766081
CardiotoxicityDeregulated Nutrient SensingSIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways.25766524
Heart failureDeregulated Nutrient SensingWe analyzed SIRT1 expression in doxorubicin-induced neonatal rat cardiomyocyte injury model and adult mouse heart failure model.25766524
Heart failureDeregulated Nutrient SensingSIRT1 agonist resveratrol was used to treat the doxorubicin-induced heart failure mouse model.25766524
Cardiac functionDeregulated Nutrient SensingThe SIRT1 agonist resveratrol was able to prevent doxorubicin-induced heart function loss.25766524
Heart Injuries, CardiomyopathiesDeregulated Nutrient SensingThese results support the role of SIRT1 as an important regulator of cardiomyocyte apoptosis during doxorubicin-induced heart injury, which may represent a potential therapeutic target for doxorubicin-induced cardiomyopathy.25766524
ObesityDeregulated Nutrient SensingBP was sensitively dependent on insulin resistance and lipid accumulation in all subjects; however, sodium intake may be an independent risk factor of obesity without increasing BP in girls.25768006
Coronary ArteriosclerosisDeregulated Nutrient SensingLower AMP-activated protein kinase level is associated with the vulnerability of coronary atherosclerotic plaques by attenuating the expression of monocyte autophagy.25768243
atheroscleroticDeregulated Nutrient SensingHowever, research on the relationship between AMP-activated protein kinase (AMPK) and vulnerable atherosclerotic plaques is still insufficient.25768243
Acute Coronary SyndromeDeregulated Nutrient SensingThe level of phosphorylated AMPK was significantly decreased in patients with acute coronary syndrome compared with those in the SAP and control groups (P<0.01).25768243
Rupture, Dental PlaqueDeregulated Nutrient SensingTherefore, our work is novel in showing that AMPK of PBMs may decrease plaque vulnerability and subsequent plaque rupture through activation of autophagy.25768243
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Dysautonomia, Familial, Hyperlipoproteinemia Type III, HyperlipoproteinemiasDeregulated Nutrient SensingFamilial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD).25768710
Steatohepatitis, Halotestin, HIV-Associated Lipodystrophy SyndromeDeregulated Nutrient SensingHIV-infected patients frequently develop HIV and highly active antiretroviral treatment-associated lipodystrophy syndrome (HALS), characterized by accumulation of intra-abdominal fat, insulin resistance, and hepatic steatosis.25769096
DyslipidemiasDeregulated Nutrient SensingPatients with dyslipidemia displayed greater amounts of lipid and calcium than those with normal lipid levels.25769575
DyslipidemiasDeregulated Nutrient SensingIn patients with dyslipidemia, calcium intake was lower than those in patients without dyslipidemia, although their intake of lipids was also lower than those without dyslipidemia.25769575
Rheumatoid ArthritisDeregulated Nutrient SensingSymmetric dimethylarginine (SDMA) serum levels in rheumatoid arthritis: correlations with insulin resistance and disease activity scores.25772817
Refractory anemias, AtherosclerosisDeregulated Nutrient SensingThe molecular explanation of lower serum SDMA is unclear, but the established relationships with indices of disease activity and insulin resistance, may underline the pathogenetic role of the L-arginine/NO pathway dysregulation in the development of atherosclerosis in RA.25772817
Hypoadiponectinemia, ObesityDeregulated Nutrient SensingInsulin resistance and central obesity have been implicated in the pathogenesis of hypoadiponectinemia in obesity.25774471
DyslipidemiasDeregulated Nutrient SensingTraditionally, the high prevalence of dyslipidemia in elderly people is considered a "natural condition."25780934
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingNotably, subclinical hypothyroidism (SCH) is one of the most important risk factors for dyslipidemia.25780934
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingLower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed.25781355
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingEmerging on the grounds of obesity, IR confers risks for dyslipidemia and hypertension at a relatively early age.25781532
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of hypertension, dyslipidemia and diabetes was higher with increased WHtR for both ethnic groups after adjusted by age.25782420
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNAFLD is closely associated with insulin resistance (IR), and although the role of IR in NAFLD has been an area of intense investigation, there are limited data on pancreatic b-cell function.25784075
Hepatobiliary Disorder, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMedical records were reviewed for the presence of diabetes, body mass index, diabetes treatment, and comorbidities at the time of biopsy (eg, underlying liver disease, hypertension, dyslipidemia).25786083
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingDiabetic patients had a higher average body mass index (33 vs. 30 m/kg, P=0.0039), prevalence of hypertension (78% vs. 33%, P<0.0001), and dyslipidemia (52% vs. 20%, P<0.0001).25786083
Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingThe AA genotype might be associated with the development of dyslipidemia in ACS patients.25788758
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDyslipidemia is one of the most important risk factors for coronary artery disease (CAD), and low-densitylipoprotein cholesterol (LDL-C) is used to measure dyslipidemia.25790545
Dyslipidemias, OverweightDeregulated Nutrient SensingThe increase in overweight and obese children may be linked to increased rates of dyslipidaemia.25793380
TG gene, DyslipidemiasDeregulated Nutrient SensingThe most common dyslipidaemia was high TG in combination (26.2%) and in isolation (10.6%).25793380
TG gene, DyslipidemiasDeregulated Nutrient SensingA high TG level was the most frequent dyslipidaemia.25793380
Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingMagnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance.25793876
physiopathologicalDeregulated Nutrient SensingBoth in vitro and in vivo experiments were designed to test the role of AMP-activated protein kinase (AMPK) in LPS-induced BBB dysfunction.25794165
Diabetes MellitusDeregulated Nutrient SensingThe same genetic variant (major allele of rs2431332) was also significantly associated with higher plasma insulin (P = 0.019), increased HOMA insulin resistance (P = 0.019), and an increased risk of incident diabetes (P = 0.001) in the pooled analysis of the discovery cohort together with the two replication cohorts (n = 20,698 and n = 7,995).25795213
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient Sensing[Erythrocyte aggregation in patients with arterial hypertension and dyslipidemia treated with pravastatin].25796944
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe study demonstrated increased erythrocyte aggregation in patients with arterial hypertension and dyslipidemia, abnormal blood lipid spectrum and lipid composition of erythrocyte membranes, activation of lipid peroxidation.25796944
Hypertension, CTCAEDeregulated Nutrient SensingCorrelated analysis and pathological study on insulin resistance and cardiovascular endocrine hormone in elderly hypertension patients.25796973
Hypertensive (finding), Hypertension, CTCAEDeregulated Nutrient SensingThis study has shown that there is a significant correlation and pathological effect between insulin resistance and cardiovascular endocrine hormone in hypertensive patients, and which plays an important role in genesis and development of hypertension in elderly people.25796973
Pancreatic Ductal AdenocarcinomaDeregulated Nutrient SensingSIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation.25798752
NeoplasmsDeregulated Nutrient SensingHaving adjusted for age, adjuvant therapy and tumor stage, we evidenced that patients with higher PER2 and lower SIRT1 expression levels showed lower mortality (p = 0.028).25798752
Carcinogenesis, Primary malignant neoplasmDeregulated Nutrient SensingIn conclusion, a severe deregulation of expression of SIRT1 and circadian genes was evidenced in the cancer specimens of PC patients, and starvation influenced gene expression in PC cell lines, suggesting that the altered interplay between SIRT1 and the core circadian proteins could represent a crucial player in the process of pancreatic carcinogenesis.25798752
Inflammation, Cushing Syndrome, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome.25799396
Dyslipidemias, Left ventricular ejection fraction, Diabetes MellitusDeregulated Nutrient SensingThere were more patients with diabetes mellitus (38.8%), dyslipidemia (86.1%) and patients with low left ventricular ejection fraction (50%).25802449
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHence age, diabetes mellitus, dyslipidemia, left ventricular ejection fraction <40%, number of damaged coronaries might be considered as predictors of CK-MB elevation after successful PCI.25802449
Insulin Resistance, Obesity, Diabetes MellitusDeregulated Nutrient SensingGut microbiota influence metabolic pathways related to the pathogenesis of obesity, insulin-resistance and diabetes.25805893
Inflammation, CER tumor staging notationDeregulated Nutrient SensingThe underlying factor could be accumulation of certain lipid moieties, such as ceramides (CER) and diacylgycerol (DAG) within muscle tissue, which are known to promote insulin resistance (IR), induce inflammation and oxidative injury, ultimately altering muscle function.25809802
Glucose Intolerance (disease), Obesity, AbdominalDeregulated Nutrient SensingAn association was found between accumulation of specific ceramide species in muscle tissue and abdominal obesity, glucose intolerance and shortening of leukocyte telomeres, although not with muscle oxidative injury or dysfunction.25809802
Islets of Langerhans hyperplasiaDeregulated Nutrient SensingLoss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice.25811804
Diabetes MellitusDeregulated Nutrient SensingFibroblast growth factor (FGF) 21 is an endocrine factor that normalizes glucose homeostasis and reduces insulin resistance in diabetes.25811804
physiopathologicalDeregulated Nutrient SensingThese findings provide evidence that FGF21 is an obligatory metabolic regulator in pancreatic islets and shed new light onto the role of endogenous FGF21 in the pathogenesis of insulin resistance and islet dysfunction.25811804
Inflammation, ObesityDeregulated Nutrient SensingAssociations of fibroblast growth factor-23 with markers of inflammation, insulin resistance and obesity in adults.25811862
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingPrior studies have shown that FGF23 concentrations are associated with markers of inflammation and insulin resistance but they have been limited by a focus on persons with chronic kidney disease (CKD) and lack of race and sex diversity.25811862
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingInsulin resistance (IR) is linked with the occurrence of pathological features observed in Alzheimer's disease (AD), including neurofibrillary tangles and amyloid plaques.25812851
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingAssociation of genetic variants with dyslipidemia and chronic kidney disease in a longitudinal population-based genetic epidemiological study.25813695
Dyslipidemias, OsteoporosisDeregulated Nutrient SensingThe effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in the high-fat-fed ovariectomized rats.25814468
Steatohepatitis, DyslipidemiasDeregulated Nutrient SensingAtorvastatin treatment prevented dyslipidemia, reversed hepatic steatosis, optimized composition of bone, and improved bone mechanical properties.25814468
Dyslipidemias, Osteoporotic FracturesDeregulated Nutrient SensingThe current study provided further evidence that atorvastatin might be useful for the treatment of osteoporotic patients with dyslipidemia.25814468
Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidemia, obesity and other cardiovascular risk factors in the adult population in Senegal.25815102
Dyslipidemias, ObesityDeregulated Nutrient SensingIn Senegal, the epidemiology of dyslipidemia and obesity are still poorly understood due to the lack of comprehensive studies on their impact on the general population.25815102
Dyslipidemias, ObesityDeregulated Nutrient SensingThe main factors significantly associated with dyslipidemia were obesity, urban dwelling, physical inactivity and a family history of dyslipidemia.25815102
Dyslipidemias, ObesityDeregulated Nutrient SensingThe prevalence of dyslipidemia, obesity and other risk factors in the population was high needing immediate care for those affected and implementation of prevention strategies.25815102
Stomach Carcinoma, Diabetes MellitusDeregulated Nutrient SensingPositive expression of Nampt, Sirt1, p53, P-gp and Topo-IIa was observed to be higher in gastric cancer with diabetes patients compared with gastric cancer patients (P=0.01, 0.003, 0.0025, 0.016 and 0.336, respectively) with reduced survival time.25815791
Tacca leontopetaloides, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHistory of stroke, high blood pressure, and dyslipidemia were significantly more frequent in patients with TIA.25817627
Hepatitis CDeregulated Nutrient SensingTNFa has been shown to play a role in hepatitis C virus (HCV)-induced insulin resistance (IR).25818002
Brain Diseases, NGFR protein, humanDeregulated Nutrient SensingmRNA levels of Ngfr, Vglut1, Mapk3, Tnf-a, and Sirt1, known targets of the down-regulated miRNAs and abnormal in various human brain disorders, were significantly increased in the HMOX-1-transfected astrocytes.25820186
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingDose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.25822499
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSmoking and its cessation showed dose- and time-dependent relationship with glycemic control and insulin resistance in patients with type 2 diabetes mellitus.25822499
Coronary Stenosis, Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes mellitus (DM), dyslipidemia and a history of revascularization was higher in the patients with coronary artery stenosis.25822806
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAccumulating evidences demonstrate that abnormalities in whole blood viscosity (WBV) have been implicated in insulin resistance which may lead to non-alcoholic fatty liver disease (NAFLD).25823525
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingWith the increase of WBV level, participants have larger waist circumference (WC), more severe insulin resistance and the prevalence of NAFLD increased significantly with elevated WBV quartiles.25823525
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn multivariable analysis, c was notably positively associated with diabetes mellitus, obesity, hypertension and dyslipidemia and negatively with current smoking.25828346
ARCN1 gene, Primary malignant neoplasm, Neoplasms, Pancreatitis, Chronic, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, ObesityDeregulated Nutrient SensingInformation on the type, intensity and duration of statin use after cancer diagnosis was extracted from Medicare Part D. We treated statin as a time-dependent variable in a Cox regression model to determine the association with overall survival adjusting for follow-up, age, sex, race, neighborhood income, stage, grade, tumor size, pancreatectomy, chemotherapy, radiation, obesity, dyslipidemia, diabetes, chronic pancreatitis and chronic obstructive pulmonary disease (COPD).25830309
melanomaDeregulated Nutrient SensingThe AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility has yet to be confirmed.25832654
Prostate carcinomaDeregulated Nutrient SensingIn prostate cancer, low adiponectin levels are not associated with insulin resistance.25833038
Malignant neoplasm of prostateDeregulated Nutrient SensingIn spite of what would have been expected from the relevant literature, our data suggest that the hypoadiponectinaemia in prostatic cancer does not appear to be associated with insulin resistance.25833038
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of hypertension, dyslipidemia and diabetes mellitus were all significantly increased from the CHART-1 to the CHART-2 Study.25833177
Hyperglycemia, Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingMultiple regression analysis revealed that hypertension, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with obesity.25833358
Proteinuria, Hyperglycemia, Dyslipidemias, Hyperuricemia, ObesityDeregulated Nutrient SensingObesity, blood pressure, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with proteinuria.25833358
Hyperglycemia, Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with obesity.25833358
Dyslipidemias, diabeticDeregulated Nutrient SensingPurified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients.25833778
Diabetes MellitusDeregulated Nutrient SensingAnthocyanin, a natural antioxidant, has been reported to reduce oxidative stress and to attenuate insulin resistance and diabetes in animal models; however, the translation of these observations to humans has not been fully tested.25833778
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese findings demonstrate that anthocyanin supplementation exerts beneficial metabolic effects in subjects with type 2 diabetes by improving dyslipidemia, enhancing antioxidant capacity, and preventing insulin resistance.25833778
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study was designed to investigate the effects of purified anthocyanins on dyslipidemia, oxidative status, and insulin sensitivity in patients with type 2 diabetes.25833778
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe dyslipidemia associated with excess weight is a risk for cardiovascular disease.25834504
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn this hospital-based study, the obese children with longer GT repeats in the HO-1 gene promoter and insulin resistance were susceptible to NAFLD.25835554
Dyslipidemias, ObesityDeregulated Nutrient SensingThe apolipoprotein B (APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity.25837208
Coronary Artery DiseaseDeregulated Nutrient SensingDifferent postprandial lipid metabolism and insulin resistance between non-diabetic patients with and without coronary artery disease.25840497
Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIn patients with abdominal obesity and hypertension were more prevalent family history of hypertension, smoking, dyslipidemia, mainly due to triglycerides, as well as higher levels of fasting glucose.25842663
Pancreatic carcinomaDeregulated Nutrient SensingSIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.25843411
Pancreatic carcinomaDeregulated Nutrient SensingUp-regulated in pancreatic cancer, SIRT1 is involved in tumorigenesis and drug resistance.25843411
Primary malignant neoplasmDeregulated Nutrient SensingHowever the mechanism through which SIRT1 regulates drug sensitivity in cancer cells is mainly unknown.25843411
Cessation of life, Pancreatic carcinomaDeregulated Nutrient SensingWe hypothesise that inhibiting SIRT1 activity may increase sensitivity of pancreatic cancer cells to gemcitabine treatment through the regulation of apototic cell death, cell cycle, epithelial-mesenschymal-transition (EMT) and senescence.25843411
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingGrowing evidence has shown that ferritin concentrations are associated with obesity and insulin resistance, and with nonalcoholic fatty liver disease.25843660
Kidney DiseasesDeregulated Nutrient SensingInsulin Resistance Increases the Risk of Contrast-Induced Nephropathy in Patients Undergoing Elective Coronary Intervention.25843952
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingPatients were divided into diabetes mellitus (DM = 242), nondiabetic IR (IR = 120), and nondiabetic insulin sensitivity (IS = 357) groups according to medical history and homeostasis model assessment insulin resistance index.25843952
Premature coronary artery atherosclerosis, DyslipidemiasDeregulated Nutrient SensingHe had cardiac risk factors, including a strong family history of pre-mature coronary artery disease and dyslipidemia.25845133
Weight decreased, DyslipidemiasDeregulated Nutrient SensingUnivariate and multivariate analysis showed that BMI <50 kg/m(2) (p = 0.006) and dyslipidaemia (p = 0.05) were predictive factors of successful weight loss.25845353
Heart failureDeregulated Nutrient SensingInsulin resistance is associated with impaired cardiac sympathetic innervation in patients with heart failure.25845954
Heart failureDeregulated Nutrient SensingInsulin resistance (IR) represents, at the same time, cause and consequence of heart failure (HF) and affects prognosis in HF patients, but pathophysiological mechanisms remain unclear.25845954
Diabetes MellitusDeregulated Nutrient SensingIn conclusion, despite arsenic's association with diabetes in adults and potential role in insulin resistance, our findings do not support the hypothesis that arsenic exposure at levels common in the US contributes to insulin resistance in adolescents.25845984
melanomaDeregulated Nutrient SensingIn melanoma cells, oncogenic BRAF constitutively activates the extracellular signal-regulated kinase (ERK) pathway and phosphorylates liver kinase B1, an upstream activator of 5' adenosine monophosphate-activated protein kinase (AMPK), resulting in the inactivation of liver kinase B1 and AMPK.25846811
Leukemia, Myelocytic, AcuteDeregulated Nutrient SensingNegative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells.25846811
Primary malignant neoplasmDeregulated Nutrient SensingRecently, AMPK has received attention as an attractive molecular target for cancer therapy.25846811
Hematologic NeoplasmsDeregulated Nutrient SensingSeveral studies have revealed that the activation of AMPK by chemical stimulators, such as metformin, induces apoptosis in a variety of hematologic malignant cells.25846811
Hematologic NeoplasmsDeregulated Nutrient SensingFrom another perspective, these results suggest that the function of AMPK is impaired in hematologic tumor cells.25846811
Adult T-Cell Lymphoma/LeukemiaDeregulated Nutrient SensingIn this study, we analyzed whether ERK is involved in the suppression of AMPK activity using established and primary human leukemia cells.25846811
Prediabetes syndrome, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe weighted prevalence of hypertension and dyslipidemia gradually increased in adults with normal glucose regulation, prediabetes, newly-diagnosed diabetes and previously-diagnosed diabetes.25848699
Degenerative polyarthritis, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is known to be an underlying cause for the development of OA.25849372
Obesity, Abdominal, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity, abdominal obesity, dyslipidemia, low education level, and a family history of diabetes were associated with glucose metabolism disorders.25850521
Demographics Domain, Dyslipidemias, Sleep disturbances, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingMultivariate logistic regression models evaluated the association between sleep disturbances with diabetes mellitus (DM) and the combined outcomes of DM and hypertension as well as DM and dyslipidemia.25856540
Sleep Apnea, CTCAEDeregulated Nutrient SensingIn fully adjusted models, sleep apnea risk was associated with the combined outcome of DM-hypertension (OR 1.95; 95% CI 1.42-2.69), but not with diabetes-dyslipidemia.25856540
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension was the single most important risk factor (71.1%) followed by smoking (46.9%) and dyslipidaemia (45.8%).25856914
Hypertensive (finding), Dyslipidemias, diabetic, Coronary heart diseaseDeregulated Nutrient Sensing83.8% of patients were hypertensive, 36.6% diabetic, 44.5% had dyslipidemia, 15.3% were smokers, 65.7% were overweight/obese, 29.3% had a family history of coronary heart disease.25859865
Alzheimers Disease", Inflammation, Data types - Address, DyslipidemiasDeregulated Nutrient SensingEpidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood.25862742
AURKAIP1 gene, Mood DisordersDeregulated Nutrient SensingComorbid mood disorders and TUD further increase AIP but not insulin resistance.25863911
Mood DisordersDeregulated Nutrient SensingThe results show that mood disorders, TUD and BMI together with elevated levels of uric acid and MDA independently contribute to increased atherogenic potential, while BMI and uric acid are risk factors for insulin resistance.25863911
Mood DisordersDeregulated Nutrient SensingThe findings show that mood disorders and TUD are closely related to an increased atherogenic potential but not to insulin resistance or the MetS.25863911
Mood DisordersDeregulated Nutrient SensingMood disorders and TUD increase triglyceride levels, lower HDL cholesterol and are strongly associated with the atherogenic, but not insulin resistance, component of the MetS.25863911
Overweight, ObesityDeregulated Nutrient SensingThe study of the incidence of overweight and obesity as well as body composition and insulin resistance in children from rural communities is scarce.25864988
Obesity, Diabetes MellitusDeregulated Nutrient SensingImpaired mitochondrial function is important in obesity and the development of insulin resistance and diabetes.25865306
niobiumDeregulated Nutrient SensingSimultaneous to P2, a 24 h hyperinsulinemic-euglycemic clamp (HEC) was performed to determine patients' insulin sensitivity (IS) or insulin resistance (IR), as well as the impact of high doses of insulin on NB.25867209
Glucose Intolerance (disease), Liver CirrhosisDeregulated Nutrient SensingImpaired gastrointestinal-mediated glucose disposal and reduced incretin effect may contribute to the glucose intolerance seen in patients with cirrhosis.25867498
Polycystic Ovary SyndromeDeregulated Nutrient SensingEffects of zinc supplementation on markers of insulin resistance and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.25868059
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingExpression of the central obesity and Type 2 Diabetes mellitus genes is associated with insulin resistance in young obese children.25868061
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingInsulin resistance may develop in early stage of childhood obesity and in very young children may be associated with higher expression of the central obesity and Type 2 Diabetes genes.25868061
CholelithiasisDeregulated Nutrient SensingVisceral adiposity is a strong determinant of insulin resistance, which decreases cholecystokinin response sensitivity, and increases cholesterol saturation in the gallbladder bile; thus, it potentially relates to gallstone disease development.25869941
HyperglycemiaDeregulated Nutrient SensingBecause of associated insulin resistance (IR) the ICU is in dilemma in which stage to start the nutrition to patients and what is the amount of Insulin Unit to control the hyperglycemia.25870478
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingTobacco smoking was the most frequent risk factor (54%), followed by dyslipidemia (48.6%) and hypertension (38.6%).25874992
Secretory Component Deficiency, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingRegarding insulin dynamics, among the NAFLD subjects with both IFG and an HbA1c level of 5.7-6.4%, 25.2% (31/123) had elevated IR alone, 25.2% (31/123) had insulin secretory deficiency alone and 27.6% (34/123) had both elevated insulin resistance and insulin secretory deficiency.25876566
HD Term Type, DyslipidemiasDeregulated Nutrient SensingIn the clinical setting, dyslipidemia can be diagnosed based on the detection of elevated lipid concentrations at the beginning of HD.25876568
Weight Gain, HD Term Type, DyslipidemiasDeregulated Nutrient SensingEvaluating the degree of dyslipidemia at the beginning of a HD session may therefore underestimate the levels of serum lipids in HD patients with a large amount of weight gain, thus resulting in the use of insufficient lipid-lowering therapy.25876568
Fatty Liver DiseaseDeregulated Nutrient SensingOral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial.25876706
Liver damageDeregulated Nutrient SensingOral administration of anti-CD3 antibodies induced regulatory T cells (Tregs) alleviating the insulin resistance and liver damage in animal models.25876706
ObesityDeregulated Nutrient SensingMost patients suffering from T2DM and from obesity exhibit insulin resistance in the muscles, liver, and fat, resulting in a reduced response of these tissues to insulin.25879401
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is a complex disease that is caused by an impairment in the secretion of b-cell insulin and by a peripheral resistance to insulin.25879401
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingAt the population level, dyslipidaemia is one of the most easily modifiable risk factors of CHD.25879518
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingThe absence of apparent b-cell deficit in case subjects with GC-induced diabetes suggests that GC-induced diabetes is mainly caused by insulin resistance and/or b-cell dysfunction, but not necessarily a deficit of b-cell mass.25883114
Dyslipidemias, Albuminuria, Hypertension, CTCAEDeregulated Nutrient SensingVery high rates of albuminuria, high rates of smoking, dyslipidaemia, hypertension and elevated BMI were recorded.25884441
TG geneDeregulated Nutrient SensingThe Triglycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C) ratio is an indirect measure of insulin resistance and an independent predictor of cardiovascular risk.25885289
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingCompared with nonobese patients without NAFLD, patients with NAFLD had severe systemic (liver/muscle) and, particularly, adipose tissue (fasting/postprandial) insulin resistance (all P < .01).25885947
OverweightDeregulated Nutrient SensingHowever, a well-assembled nutraceutical would be a useful tool to better improve the metabolic parameters associated to overweight and insulin resistance.25886384
HyperlipidemiaDeregulated Nutrient SensingClinical and laboratory data associated to hyperlipidaemia and insulin resistance have been obtained at the baseline, at the end of the first treatment period, after the washout, and again after the second treatment period.25886384
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients.25887236
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) plays a vital role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM).25887236
Chronic Kidney DiseasesDeregulated Nutrient SensingSIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells.25889431
Demographics Domain, Dyslipidemias, Haiti, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFor the highest quartile of the mean carotid IMT (>= 0.863 mm), a male sex, older age, hypertension (HT), dyslipidemia (DL) and type 2 diabetes mellitus (DM) were identified as independent predictors.25891209
Glucose Intolerance (disease)Deregulated Nutrient SensingThese results suggest that the inhibition of SGLT2 and DPP4 improves glucose intolerance and that combined treatment with canagliflozin and teneligliptin is a novel therapeutic option for glycemic control in T2DM.25892328
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes was associated with ageing, dyslipidaemia, family history of diabetes, lower physical activity on occupation, intake of lower dietary fibre, and non-literacy in the sampled population.25895201
Diabetes Mellitus, diabeticDeregulated Nutrient Sensing* Type 2 diabetes mellitus is associated with impaired cognition * Default- mode network plays a central role in maintaining normal cognition * Network connectivity within the default mode was disrupted in type 2 diabetes patients * Decreased network connectivity was correlated with cognitive performance and insulin resistance level * Disrupted default-mode network might explain the impaired cognition in diabetic population.25903712
ARCN1 geneDeregulated Nutrient SensingAlthough the circadian molecular clock regulates inflammatory responses, there is no information available regarding the impact of COPD on lung molecular clock function and its regulation by sirtuin 1 (SIRT1).25905433
ARCN1 geneDeregulated Nutrient SensingWe hypothesize that the molecular clock in the lungs is disrupted, leading to increased inflammatory responses in smokers and patients with COPD and its regulation by SIRT1.25905433
ARCN1 geneDeregulated Nutrient SensingIn conclusion, disruption of the molecular clock due to SIRT1 reduction contributes to abnormal inflammatory response in smokers and patients with COPD.25905433
Inflammation, Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingDisruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.25905433
HyperleucinemiaDeregulated Nutrient SensingHyperleptinaemia, insulin resistance and survival in peritoneal dialysis patients.25907108
palladiumDeregulated Nutrient SensingThe aim of this study was to clarify the relationship between insulin resistance (IR) and glucose and lipid metabolism in peritoneal dialysis (PD) patients.25907108
Familial generalized lipodystrophy, Muscle hypertrophyDeregulated Nutrient SensingBerardinelli-Seip congenital lipodystrophy (BSCL) is a very rare disease characterized by near absence of adipose tissue resulting in apparent muscle hypertrophy from birth or early infancy associated with severe insulin resistance.25910311
Apolipoproteins BDeregulated Nutrient SensingDiscordance between apolipoprotein B and low-density lipoprotein particle number is associated with insulin resistance in clinical practice.25911082
Discordance, InflammationDeregulated Nutrient SensingDiscordance (LDL-PNMR > apoB) was associated with insulin resistance, smaller LDL particle size, increased systemic inflammation, and low circulating levels of "traditional" lipids, whereas discordance (apoB > LDL-PNMR) was associated with larger LDL particle size, and elevated levels of lipoprotein(a) and lipoprotein-associated phospholipase A2 (Lp-PLA2).25911082
Dental PlaqueDeregulated Nutrient SensingThe role of insulin resistance and metabolic risk factors on culprit coronary plaque.25912124
Dental PlaqueDeregulated Nutrient SensingWe investigated the role of insulin resistance (IR) on culprit coronary plaque.25912124
Non-Small Cell Lung Carcinoma, NeoplasmsDeregulated Nutrient SensingProtein levels of SIRT1 and SIRT2 were determined in non-small cell lung cancer (NSCLC) cell lines and primary tumors from 105 patients.25915617
Carcinoma of lungDeregulated Nutrient SensingChanges in proliferation were assessed after SIRT1 and SIRT2 downregulation in lung cancer cell lines using siRNA-mediated technology or tenovin-1, a SIRT1 and SIRT2 inhibitor.25915617
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingHigh SIRT1 and SIRT2 protein levels were found in NSCLC cell lines compared with non-tumor lung epithelial cells.25915617
Primary NeoplasmDeregulated Nutrient SensingThe expression of SIRT1 and SIRT2 proteins was also significantly higher in lung primary tumors than in normal tissue (P<0.001 for both sirtuins).25915617
Adenocarcinoma, Squamous cell carcinomaDeregulated Nutrient SensingStronger nuclear SIRT1 staining was observed in adenocarcinomas than in squamous cell carcinomas (P=0.033).25915617
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingInterestingly, in NSCLC patients, high SIRT1 and SIRT2 expression levels were associated with shorter recurrence-free survival (P=0.04 and P=0.007, respectively).25915617
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingIn vitro studies showed that SIRT1 and/or SIRT2 downregulation significantly decreased proliferation of NSCLC.25915617
Carcinoma of lungDeregulated Nutrient SensingOur results support the hypothesis that SIRT1 and SIRT2 have a protumorigenic role in lung cancer, promoting cell proliferation.25915617
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingExpression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.25915617
Hyperglycemia, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThe presence of abdominal obesity, hyperglycaemia, dyslipidaemia and elevated blood pressure was clinically evaluated in 1994-96.25918184
Hyperglycemia, Metabolic Diseases, Dyslipidemias, ObesityDeregulated Nutrient SensingSignificant associations were also found with several cardiometabolic disorders (hyperglycaemia, central obesity and dyslipidaemia) and specific cognitive domains.25918184
T-Cell Lymphoma, NeoplasmsDeregulated Nutrient SensingThe mTORC1 inhibitor everolimus has antitumor activity in vitro and produces tumor responses in patients with relapsed T-cell lymphoma.25921059
SimultaneousDeregulated Nutrient SensingCompared to baseline, metformin significantly improved metabolic parameters and insulin sensitivity, increased SIRT1 gene/protein expression and SIRT1 promoter chromatin accessibility, elevated mTOR gene expression with concomitant reduction in p70S6K phosphorylation in subjects' PBMCs, and modified the plasma N-glycan profile.25921843
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingAssociation between atherogenic dyslipidemia and recurrent stroke risk in patients with different subtypes of ischemic stroke.25924059
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingThe association between atherogenic dyslipidemia and stroke recurrence remains unclear, and may be influenced by different subtypes of ischemic stroke.25924059
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingWe aimed to investigate whether atherogenic dyslipidemia contributed to stroke recurrence in ischemic stroke patients and in those with certain subtypes of ischemic stroke.25924059
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia was defined as high-density lipoprotein cholesterol <40 mg/dl and triglycerides >=200 mg/dl.25924059
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingThe association between atherogenic dyslipidemia and stroke recurrence was analyzed by using multivariable Cox regression model.25924059
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingIn the 510 ischemic stroke patients, 64 patients (12*5%) had atherogenic dyslipidemia, and 66 patients (12*9%) experienced stroke recurrence events within 24 months.25924059
Atherosclerosis of renal artery, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingKaplan-Meier analysis revealed that stroke recurrence rate was significantly higher in patients with atherogenic dyslipidemia than those without in all the stroke patients (20*3% vs. 11*9%; P = 0*048), and more evident in those of large-artery atherosclerosis subtype (31*0% vs. 14*1%; P = 0*014), but not in the other subtypes.25924059
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingAtherogenic dyslipidemia is associated with higher risk of stroke recurrence in ischemic stroke patients.25924059
Dyslipidemias, Toxic effectDeregulated Nutrient SensingA better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM.25924608
Inflammation, Angina Pectoris, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, atheroscleroticDeregulated Nutrient SensingInflammation and dyslipidaemia may play an important role in the development of atherosclerotic complications, for example myocardial infarction and angina pectoris.25924966
Autoimmune thyroiditis, Adrenal incidentalomaDeregulated Nutrient SensingThe association of autoimmune thyroiditis and non-functional adrenal incidentalomas with insulin resistance.25926113
Dyslipidemias, Non-Functioning Adrenal Cortex Adenoma, ObesityDeregulated Nutrient SensingPatients with incidental nonfunctioning adrenal adenoma are associated with increased risk of obesity, impaired glucose tolerance and dyslipidemia.25926113
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe association did not persist after additionally adjusting for traditional atherogenic risk factors including visceral fat, smoking, hypertension, dyslipidemia, and diabetes.25935114
Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHyperglycaemia and dyslipidaemia in diabetes mellitus induce increased lipid peroxidation and peroxyl radical formation is an important mechanism in genesis of micro-angiopathy.25935946
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSkeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D).25937284
Mitochondrial BiogenesisDeregulated Nutrient SensingFinally, activation of AMPK by A-769662 increased PGC-1a expression via SIRT-1 and reversed impairments in mitochondrial biogenesis, oxidative phosphorylation, and intracellular ATP in human knee OA chondrocytes.25940958
Degenerative polyarthritisDeregulated Nutrient SensingTFAM-mediated activation of the AMPK/SIRT-1/PGC-1a pathway reverses these effects, suggesting translational potential of pharmacologic AMPK activators to limit OA progression.25940958
Increased insulin level, Hypertensive (finding)Deregulated Nutrient SensingHigher Waist Circumference, Fasting Hyperinsulinemia And Insulin Resistance Characterize Hypertensive Patients With Impaired Glucose Metabolism.25944063
Increased insulin level, Hypertensive (finding)Deregulated Nutrient SensingThe present study, performed in a selected population of hypertensive subjects, shows that derangement of glucose metabolism is associated to central fat accumulation, hyperinsulinemia and insulin resistance.25944063
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin Resistance and Risk of Cardiovascular Disease in Postmenopausal Women: A Cohort Study From the Women's Health Initiative.25944628
Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is associated with diabetes mellitus, but it is uncertain whether it improves cardiovascular disease (CVD) risk prediction beyond traditional cardiovascular risk factors.25944628
Diabetes MellitusDeregulated Nutrient SensingMeasures of insulin resistance were no longer associated with CVD risk after adjustment for high-density lipoprotein-cholesterol and did not provide independent prognostic information in postmenopausal women without diabetes mellitus.25944628
DyslipidemiasDeregulated Nutrient SensingThese findings may aid in predicting a patient's risk of developing dyslipidemia.25944971
Amyotrophic Lateral Sclerosis, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance in patients with amyotrophic lateral sclerosis (ALS) has been inconsistently reported.25947580
Refractory anemias, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese results show that circulating RA concentrations were lower in subjects with NAFLD and were associated with hepatic lipid metabolism and insulin resistance.25948673
Gestational Diabetes, Glucose Intolerance (disease)Deregulated Nutrient SensingPrevalence of glucose intolerance at 6 weeks postpartum in Indian women with gestational diabetes mellitus.25952037
Gestational Diabetes, Glucose Intolerance (disease), Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingWomen with a history of gestational diabetes mellitus (GDM) have an increased risk for future glucose intolerance, and should be followed up with subsequent screening for the development of diabetes or pre-diabetes at 6-12 weeks postpartum.25952037
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingMetabolically obese but normal weight (MONW) is associated with higher risk of type 2 diabetes, dyslipidemia, and hypertension.25952300
Heart Diseases, Dyslipidemias, OverweightDeregulated Nutrient SensingGeneral practitioners considered most frequently the presence of underlying heart disease (C: 35.0%, G: 5.0%, MG: 45.0%; P<0.05) as well as usual cardiovascular risk factors (overweight, dyslipidaemia; P<0.05).25956749
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingCarotid atherosclerosis in patients with ESKD has decreased over the past 9 years, which may be a consequence of improvements in dyslipidemia management.25957119
Osage languageDeregulated Nutrient SensingIn contrast, neither insulin resistance nor sleep measurements related to OSA were found to be modified by fetuin-A concentrations.25960379
ETV3 wt Allele, Osage languageDeregulated Nutrient SensingIn conclusion, abnormalities of lipoprotein metabolism, but not MetS or insulin resistance per se, may represent a mechanism by which fetuin-A contributes to increased CVD risk in patients with OSA.25960379
Alzheimers Disease", ObesityDeregulated Nutrient SensingBiomarkers of Alzheimer disease, insulin resistance, and obesity in childhood.25963004
Fatty degeneration, Diabetes Mellitus, Non-Insulin-Dependent, Skeletal muscle structureDeregulated Nutrient SensingIt has recently been reported that myosteatosis, the infiltration of fat in skeletal muscle, is associated with insulin resistance and type 2 diabetes mellitus.25963482
Pancreatic carcinomaDeregulated Nutrient SensingEctopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc.25965392
Tumor necrosis, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe examined changes in adiponectin (APN) and tumor necrosis factor-a (TNF-a) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resistance (IR).25966055
Glucose Intolerance (disease), RhabdomyositisDeregulated Nutrient SensingMyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.25968578
Glucose Intolerance (disease)Deregulated Nutrient SensingPhysical inactivity in older adults is a risk factor for developing glucose intolerance and impaired skeletal muscle function.25968578
Glucose Intolerance (disease), MyositisDeregulated Nutrient SensingWe hypothesize that a physical inactivity stimulus, capable of inducing glucose intolerance, would increase skeletal muscle inflammation and ceramide biosynthesis signaling and that this response would be regulated by the TLR/MyD88 pathway.25968578
ObesityDeregulated Nutrient SensingAssociation between Obesity Indices and Insulin Resistance among Healthy Korean Adolescents: The JS High School Study.25970186
ObesityDeregulated Nutrient SensingTo investigate whether indices of obesity are associated with insulin resistance in Korean adolescents.25970186
ObesityDeregulated Nutrient SensingLogistic regression models were used to estimate odds ratio for insulin resistance according to seven obesity indices.25970186
ObesityDeregulated Nutrient SensingOur findings suggest that obesity indices are positively associated with insulin resistance in apparently healthy adolescents.25970186
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLiver fat accumulation, as reflected by the FLI, and dyslipidemia, as reflected by triglycerides, may partly explain the association between estimated D5D, D6D, and SCD activity and T2D risk.25971719
Sleep Apnea, ObstructiveDeregulated Nutrient SensingInsulin resistance using HOMA model in obstructive sleep apnea: a cross sectional study.25971819
Osage languageDeregulated Nutrient SensingCurrent evidences show inconclusive association between OSA and insulin resistance (IR).25971819
Acute Lung InjuryDeregulated Nutrient SensingChanged profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1.25972997
Acute Lung InjuryDeregulated Nutrient SensingmiR-320 may mediate the ALI after CPB in which alveolar epithelial cells are injured via down-regulating SIRT1.25972997
Cancer-related fatigue, DyslipidemiasDeregulated Nutrient SensingOur investigation reveals a differential trajectory of lipids and lipoproteins with aging according to CRF in healthy men and suggests that promoting increased CRF levels may help delay the development of dyslipidemia.25975472
RECIL MR, Dyslipidemias, Coronary Artery Disease, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingPatients with increasing grade of MR were elder (P<0.001), more likely to be female (P=0.003), have atrial fibrillation (P<0.001), higher peak C-reactive protein values (P=0.001), multivessel coronary artery disease (P<0.001), and less likely to have dyslipidemia (P=0.029).25975877
Hepatitis B, Fever, CTCAE, Headache, DyslipidemiasDeregulated Nutrient SensingA 61-year-old man with chronic hepatitis B and dyslipidemia visited the emergency department with a fever and severe headache.25977161
Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient Sensingto study the association of two miRNAs; 9 and 370, with biochemical parameters of type 2 diabetic (T2D), dyslipidemia and coronary artery disease (CAD).25978320
Diabetes MellitusDeregulated Nutrient SensingLack of regular physical activity at prescribed intensity levels is a modifiable risk factor for insulin resistance and the development of diabetes.25979318
Diabetes MellitusDeregulated Nutrient SensingThe primary objective of the Aerobic Plus Resistance Training and Insulin Resistance in African American Men (ARTIIS) study is to determine the effectiveness of an exercise training intervention aimed at reducing diabetes risk factors in African American men at risk for developing diabetes.25979318
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingDrugs for hyperglycaemia, hypertension, and dyslipidaemia were prescribed by protocol.25979364
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAlso in this setting, dyslipidemia (P = .068) showed a tendency of association with hypertension.25979413
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe adverse effects of hyperglycemia may be potentiated when it is accompanied with hypertension and dyslipidemia.25982678
ETV3 wt AlleleDeregulated Nutrient SensingThe predominant underlying mechanism of MetS is insulin resistance (IR).25984973
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidaemia is the main risk factor for coronary heart disease (CHD).25985729
Colorectal Neoplasms, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes and dyslipidemia have been linked to an increased risk of colorectal neoplasm (CRN).25986527
Dyslipidemias, Obesity, Abdominal, Congenital Heart DefectsDeregulated Nutrient SensingWomen with NWO had cardiometabolic abnormalities including abdominal obesity, dyslipidaemia and increased blood pressure.25987469
Arterial Stiffness, Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Dental PlaqueDeregulated Nutrient SensingAdvanced fibrosis indicated by NFS was positively associated with CIMT, presence of carotid plaque and arterial stiffness in the NAFLD patients, independent of conventional cardiometabolic risk factors and insulin resistance.25988358
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingLifestyle changes and statins are the cornerstones in management of dyslipidaemia in patients with HIV infection.25989829
Sarcopenia, ObesityDeregulated Nutrient SensingIn males, obesity (OR=3.7; 95% CI 1.2, 10.8), insulin resistance (OR=3.0; 95% CI 1.1, 8.2), physical inactivity (OR=2.9; 95% CI 1.1, 7.7) and sarcopenia (OR=21.2; 95% CI 4.2, 107.5) significantly increased the risk of MetS.25990645
SarcopeniaDeregulated Nutrient SensingIn both sexes, sarcopenia and insulin resistance were important risk factors of MetS.25990645
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOver time, there was a significant increase in physical inactivity, alcohol consumption, diabetes, dyslipidemia, and excessive weight.25993592
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension was present in 29.7% of patients, followed by diabetes (14.9%), current tobacco use (7.6%), and dyslipidemia (6.5%).25994444
DyslipidemiasDeregulated Nutrient SensingThere is growing evidence that glucose fluctuation, as a residual risk apart from dyslipidemia, is an important factor contributing to the development of CAD.25999102
Carcinogenic Chlorinated Hydrocarbon, Hepatitis B, ChronicDeregulated Nutrient SensingFirst, elevated AGE levels were observed in CHC patients than patients with chronic hepatitis B, especially in those with insulin resistance.26002589
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes MellitusDeregulated Nutrient SensingSeveral studies have reported that insulin resistance was a major risk factor for the onset of type 2 diabetes mellitus in individuals without diabetes or obesity.26005064
Obesity, Diabetes MellitusDeregulated Nutrient SensingWe aimed to clarify the association between insulin resistance and glycemic control in Japanese subjects without diabetes or obesity.26005064
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease.26006114
Overgrowth, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingDespite not differing in dietary pattern or prevalence of intestinal overgrowth, fasting ethanol levels being positively associated with measures of insulin resistance were significantly higher in children with NAFLD than in controls.26006114
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, hypertension and dyslipidemia were the most frequent common co-morbidities.26006196
Abnormality of mitochondrial metabolismDeregulated Nutrient SensingFurthermore, linagliptin alleviated Ab-induced mitochondrial dysfunction and intracellular ROS generation, which may be due to the activation of 5' AMP-activated protein kinase (AMPK)-Sirt1 signaling.26010513
Data types - Address, diabeticDeregulated Nutrient SensingThis upregulation of Sirt1 expression was also observed in diabetic patients with AD coadministration of linagliptin.26010513
Inflammation, Dyslipidemias, ObesityDeregulated Nutrient SensingEvidence shows a high incidence of insulin resistance, inflammation and dyslipidemia in adult obesity.26011530
Inflammation, OverweightDeregulated Nutrient SensingThe overweight subjects only exhibited significant insulin resistance and low-grade inflammation.26011530
MeningiomaDeregulated Nutrient SensingMerlin expression, encoded by the NF2 gene, is lost in a majority of meningiomas, and merlin is a negative regulator of mTORC1.26015296
Microalbuminuria, Dyslipidemias, Retinal Diseases, Diabetic Ketoacidosis, Hypertension, CTCAEDeregulated Nutrient SensingAn inverse association between PA and HbA(1c), diabetic ketoacidosis, BMI, dyslipidemia (all P < 0.0001), and hypertension (P = 0.0150), as well as between PA and retinopathy or microalbuminuria (both P < 0.0001), was present.26015557
Dyslipidemias, Ischemic stroke, AtherosclerosisDeregulated Nutrient SensingThe connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development.26016451
DyslipidemiasDeregulated Nutrient SensingA low testosterone level in men is associated with increased adiposity, insulin resistance, and dyslipidemia.26022684
DyslipidemiasDeregulated Nutrient SensingThese results indicate that, although not associated with T2DM, the G allele of rs3480 appears to be associated with increased HbA1c, while the T allele of rs1746661 appears to be associated with higher systolic blood pressure and dyslipidemia in women with T2DM.26024756
APP gene, Dyslipidemias, SmokingDeregulated Nutrient SensingSmoking, dyslipidemia, and rs1800469 together contributed to the risk of AAA, which demonstrated a potential and complex gene-environment interaction among the three variants that might affect AAA risk (CVC 6/10; p = .001).26027897
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular events correlated with CAD severity (HR 2.27, 95% CI 1.13-4.54), age (HR 1.04, 1.01-1.06), previous cardiovascular disease (HR 1.75, 1.05-4.42), dyslipidemia (HR 2.25, 1.11-4.53), lipoprotein (a) (HR 1.01, 1.00-1.02), troponin I (HR 3.89, 1.07-14.18), fibrinogen levels (HR 1.38, 0.98-1.94) and antiplatelet therapy (HR 2.14, 1.04-4.4).26029907
Having administered, Hypogonadism, DyslipidemiasDeregulated Nutrient SensingThe Effect of Testosterone and Fenofibrate, Administered Alone or in Combination, on Cardiometabolic Risk Factors in Men with Late-Onset Hypogonadism and Atherogenic Dyslipidemia.26031507
Hypogonadism, DyslipidemiasDeregulated Nutrient SensingOur study shows that fenofibrate produces a stronger effect on cardiometabolic risk factors in men with late-onset hypogonadism and atherogenic dyslipidemia than oral testosterone undecanoate.26031507
Acute Coronary Syndrome, Heart failureDeregulated Nutrient SensingAdmission Glycaemia and Acute Insulin Resistance in Heart Failure Complicating Acute Coronary Syndrome.26031570
Acute heart failure, F8 wt AlleleDeregulated Nutrient SensingFew data are so far available on the relation between increased glucose values and insulin resistance and mortality at short-term in patients with acute heart failure (AHF).26031570
Cessation of lifeDeregulated Nutrient SensingAdmission glycaemia was an independent predictor of in-ICCU mortality, together with admission LVEF and eGFR, while acute insulin resistance (as indicated by HOMA-index) was not associated with early death.26031570
Communicable DiseasesDeregulated Nutrient SensingNutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection.26031763
herpesvirus 1, humanDeregulated Nutrient SensingWe previously showed that the sensors AMP-dependent kinase (AMPK) and Sirtuin 1 (Sirt1), involved in survival pathways and neuroprotection, were affected during the course of HSV-1 infection.26031763
Communicable Diseases, Liver damageDeregulated Nutrient SensingThese results suggest that activators of the AMPK/Sirt1 axis could be potentially useful in reducing the risk of HSV-1 productive infection in neurons and the cellular damage associated with reactivation episodes.26031763
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe assessed 106 T2DM patients, median age 62 years, 46% women, 19% smokers, 54% with hypertension, and 41% with dyslipidemia and 99 non-diabetic subjects matched by age, sex, and cardiovascular risk factors.26033395
AcromegalyDeregulated Nutrient SensingVAT and SAT masses were lower than predicted in active acromegaly, but increased after surgery in male and female subjects along with lowering of GH, IGF-I, and insulin resistance.26037515
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD) has been proposed as the hepatic manifestation of the metabolic syndrom (Ms), with insulin resistance (IR) as the common pathophysiological mechanism.26040357
AsthmaDeregulated Nutrient SensingIncreases in peripheral SIRT1: a new biological characteristic of asthma.26040995
AsthmaDeregulated Nutrient SensingHowever, no data are available regarding SIRT1 expression in patients with asthma.26040995
AsthmaDeregulated Nutrient SensingHere, we studied SIRT1 levels in the serum of patients with asthma and analysed the distribution of SIRT1 in both the serum and the lungs in an asthmatic mouse model to determine its clinical significance.26040995
eosinophil, AsthmaDeregulated Nutrient SensingSerum SIRT1 levels, total immunoglobulin E (IgE) levels and peripheral blood eosinophil percentages as well as pulmonary function were quantified in 97 patients with asthma and 118 healthy volunteers.26040995
AsthmaDeregulated Nutrient SensingBALB/c mice were sensitized and challenged using ovalbumin (OVA) to produce the asthmatic model, and SIRT1 levels in both the serum and the lung tissues were subsequently measured.26040995
AsthmaDeregulated Nutrient SensingThe serum SIRT1 levels were significantly elevated in the patients with asthma compared with the controls.26040995
AsthmaDeregulated Nutrient SensingThese data indicate that lung SIRT1 expression decreased while serum SIRT1 increased in the setting of asthma.26040995
AsthmaDeregulated Nutrient SensingSerum SIRT1 levels correlate positively with both IgE levels and negatively with pulmonary function, suggesting that increased peripheral SIRT1 levels represent a new biological characteristic of asthma.26040995
AsthmaDeregulated Nutrient SensingIncreased serum SIRT1 may be an auxiliary index for the diagnosis of asthma and elevating lung SIRT1 levels may be a new strategy for asthma therapy.26040995
Diabetic Nephropathy, Diabetes MellitusDeregulated Nutrient SensingGlycosphingolipids (GSLs) play a role in insulin resistance and diabetes, but their role in diabetic nephropathy (DN) has received limited attention.26041445
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia remains a significant risk factor for cardiovascular disease and additional lipid-modifying treatments are warranted to further decrease the cardiovascular disease burden.26047975
Increased insulin level, Sensorineural Hearing Loss (disorder), Cone-Rod Dystrophy 2, Diabetes Mellitus, Autosomal Recessive Disorder, Liver Dysfunction, ObesityDeregulated Nutrient SensingAlstrom syndrome (AS) is an autosomal recessive disorder, characterized by cone-rod dystrophy, sensorineural hearing loss, obesity, hyperinsulinemia with insulin resistance, type 2 diabetes mellitus and progressive pulmonary, hepatic and renal dysfunction.26048691
Depression, CTCAE, Polycystic Ovary SyndromeDeregulated Nutrient SensingPutative role for insulin resistance in depression risk in polycystic ovary syndrome.26054555
Prostate Cancer Outcomes Study, Depression, CTCAE, ObesityDeregulated Nutrient SensingOur data suggest a complex interplay among insulin resistance, obesity, and depression in PCOS, warranting additional investigation.26054555
NeoplasmsDeregulated Nutrient SensingSeveral members of the SIRT family (SIRT1-7), which are a highly conserved family of NAD(+)-dependent enzymes, play an important role in tumor formation.26054687
Inflammation, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results provide further support of "kynurenine hypothesis of insulin resistance and its progression to T2D" that suggested that overproduction of diabetogenic KP metabolites, induced by chronic stress or chronic low-grade inflammation, is one of the mechanisms promoting development of T2D from pre-diabetes.26055228
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingSerum retinol-binding protein 4 (RBP4) is the sole specific transport protein for retinol in the blood, but it is also an adipokine with retinol-independent, proinflammatory activity associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease.26055327
DyslipidemiasDeregulated Nutrient SensingIn general, the cut-off values of the anthropometric predictors of dyslipidemia increased with age, except for waist-to-height ratio.26057185
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough green and yellow vegetables have beneficial effects against type 2 diabetes, the relationship of their nutritive content with insulin resistance is poorly understood.26059371
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia was 15%, increased with age (p = < 0.01) did and not differ significantly according to sex.26060959
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe prevalence of dyslipidemia in the central-west of Brazil was increased with age and was associated with bean consumption, excess weight (overweight and obesity) and self-rated health as poor.26060959
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingGlucose fluctuation has been recognized as a residual risk apart from dyslipidemia for the development of coronary artery disease (CAD).26062762
Diabetes MellitusDeregulated Nutrient SensingDaily Physical Activity Assessed by a Triaxial Accelerometer Is Beneficially Associated with Waist Circumference, Serum Triglycerides, and Insulin Resistance in Japanese Patients with Prediabetes or Untreated Early Type 2 Diabetes.26064983
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObjectively measured daily physical activity is beneficially associated with waist circumference, serum triglycerides, and insulin resistance in individuals with prediabetes or untreated early T2D.26064983
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCompared to low-risk patients, patients who underwent ICAwere older, and had a higher frequency of hypertension, diabetes mellitus and dyslipidemia.26065214
ARCN1 gene, InflammationDeregulated Nutrient SensingLung function, leukocyte telomere length, lymphocyte gene expression of anti-aging (sirtuin 1, total klotho, and soluble klotho [Sklotho]), senescence (p16/21), and DNA repair (Ku70/80 and TERF2) proteins, and markers of systemic inflammation and oxidative stress were determined in 160 patients with COPD, 82 smoking subjects, and 38 never-smoking control subjects.26066545
DyslipidemiasDeregulated Nutrient SensingPrevious studies suggested that dyslipidemia was potentially associated with anti-diabetic medications of sulfonylureas (SUs).26066789
Triglycerides, Dyslipidemias, Data types - Address, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of undiagnosed diabetes, high triglycerides, high low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and atherogenic dyslipidemia (AD) was 4.7%, 31.8%, 31.3%, 25.9%, and 14.6%, respectively.26068010
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe association between white rice consumption and diabetes and dyslipidemia markers varied across regions of China, suggesting a role of other dietary and health-related exposures, beyond rice.26068010
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObese elderly women with and without type 2 diabetes have a similar degree of insulin resistance of protein anabolism, despite worse glucose metabolism in type 2 diabetes.26068615
Inflammation, Diabetes MellitusDeregulated Nutrient SensingLow-grade inflammation, as measured by hs-CRP level, may have an important role in the development of diabetes among African Americans with a lesser degree of insulin resistance.26068864
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of hypertension, dyslipidemia and diabetes was 33.5, 17.5, 5% respectively.26068976
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingPlasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance.26073386
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingChinese patients with obesity and type II diabetes have significantly lower plasma CTRP-3 concentrations than healthy subjects do, and plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance.26073386
Xanthoma, Arteriosclerosis, DyslipidemiasDeregulated Nutrient SensingGiant xanthomas associated with severe mixed dyslipidemia and arteriosclerotic vascular disease: A case report.26073402
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe prevalence of undiagnosed diabetes was 2.6% (29 individuals); glucose intolerance was detected in 1.3% (14 individuals).26074216
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThere is a low prevalence of undiagnosed diabetes and glucose intolerance in the rural population of River Nile State.26074216
Rectum, Fibromyalgia, Dyslipidemias, Depression, CTCAE, Ichthyosis Bullosa of SiemensDeregulated Nutrient SensingThe most common associated diseases observed in patients with IBS were: depression (27.19%), dyslipidemia (25.43%), hemorrhoidal disease (22.80%) and fibromyalgia (21%).26076563
Rectum, Fibromyalgia, DyslipidemiasDeregulated Nutrient SensingOther diseases with a high incidence: dyslipidemia, hemorrhoidal disease and fibromyalgia.26076563
Atherosclerosis, Dyslipidemias, Cerebrovascular accident, Heart Diseases, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingRisk factors of stroke such as hypertension, diabetes mellitus, dyslipidemia, atherosclerosis, stroke history, and heart disease were recorded.26077180
Diabetes MellitusDeregulated Nutrient SensingHigher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance.26077345
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, correlations with FBG and insulin resistance were diminished in T2D subjects.26077345
Hyperparathyroidism, Primary, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrevious studies demonstrated insulin resistance and increased prevalence of impaired glucose tolerance and type 2 diabetes mellitus in patients with primary hyperparathyroidism (PHPT).26077384
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAll patients received a personalized dietary guideline with nutritional recommendations for dyslipidemia and hypertension and were followed for 90 days.26077768
Steatohepatitis, PsoriasisDeregulated Nutrient SensingTo investigate spleen status in psoriasis and its relationship with hepatic steatosis, Psoriasis Area and Severity Index, and insulin resistance.26078565
PsoriasisDeregulated Nutrient SensingThe following relevant data were collected: age, sex, weight, height, body mass index, waist circumference, blood pressure, insulin resistance status, age at psoriasis onset, and severity of psoriasis.26078565
DyslipidemiasDeregulated Nutrient SensingType 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation.26083362
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingIn multivariable logistic regression analysis female sex, BMI, WC, WHR and WHtR, HTN and dyslipidaemia remain significantly more common among high risk participants (p < 0.05 and p < 0.001).26084331
Diabetes MellitusDeregulated Nutrient SensingIngestion of probiotics can modify gut microbiota and alter insulin resistance and diabetes development in rodents.26084343
Dyslipidemias, IFNG wt Allele, Obesity, Diabetes MellitusDeregulated Nutrient SensingAge, male gender, obesity, urban residency, high family income and presence of dyslipidaemia were found to be significant risk factors for diabetes and IFG.26085648
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingEighty percent of participants (n = 83) fell into the mEOSS-2 group and had obesity-related chronic disorders, such as diabetes, hypertension, and/or dyslipidemia.26086402
Diabetes MellitusDeregulated Nutrient SensingDiabetes was defined by calculated measures of glycemic control and insulin resistance.26087382
Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingWithin a population of 146,064 patients with dyslipidemia in the PINNACLE Registry and a subgroup of 36,188 patients with diabetes mellitus (DM), we examined the proportion of patients and patient characteristics associated with having LDL-C, non-HDL-C, and both LDL-C and non-HDL-C levels at National Cholesterol Education Program goals.26089010
Steatohepatitis, Fat-free mass, muscle massDeregulated Nutrient SensingFat-free mass and muscle mass significantly increased, whereas hepatic steatosis grade, mean insulin and ferritin levels, and the homeostasis model assessment-estimated insulin resistance index were significantly decreased in the exercise group.26090879
Cessation of life, Adult T-Cell Lymphoma/LeukemiaDeregulated Nutrient SensingNovel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells.26091232
TRPV6 geneDeregulated Nutrient SensingWe previously reported that ATL patients had significantly higher SIRT1 protein levels than healthy controls.26091232
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingDiscriminatory value of alanine aminotransferase for diabetes prediction: the Insulin Resistance Atherosclerosis Study.26094705
Glucose Intolerance (disease)Deregulated Nutrient SensingThe crude average of the maximum IMT increased significantly with rising quartiles of HbA1c, GA, FPG, and 2-hour PG levels in subjects with and without glucose intolerance (GI), while no clear association was observed for 1,5-AG.26099223
Dyslipidemias, Diverticular Bleeding, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingIn univariate analysis, hypertension, dyslipidemia, chronic kidney disease, and NSAIDs use, low-dose aspirin, non-aspirin antiplatelets, increasing BMI, and increasing VAT area were associated with diverticular bleeding.26099321
Diabetes, Autoimmune, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingVitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults.26101151
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, ObesityDeregulated Nutrient SensingAmong cardiovascular risk factors, dyslipidemia, obesity, smoking, and a family history of CVD did not affect self-perceived health.26103790
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.26105582
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe aim of the current study is to investigate the effect of fenofibrate alone and in combination with pioglitazone on serum sirtuin 1 and fetuin A of obese patients with Type 2 Diabetes Mellitus (T2DM).26105582
ObesityDeregulated Nutrient SensingFenofibrate, alone and in combination with pioglitazone, significantly decreased triacylglycerol, hs-CRP, IL-6, fetuin A and increased sirtuin 1 levels (P<0.001) which suggests that it can be used to delay the complications of obesity and T2DM.26105582
Dyslipidemias, Diabetes Mellitus, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingPatients had multiple risk factors at inclusion on renal transplantation waiting list as high blood pressure (94.7%), dyslipidemia (81.1%), smoking (45.3%), diabetes (23.6%), past history of cardiovascular disease (21.3%) and obesity (12.7%).26107641
Neuropathology, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingThe present results suggest that AD-like neuropathology extends to the pancreas in the 3xTg-AD mouse, leading to glucose intolerance and contributing to a pathologic self-amplifying loop between AD and T2D.26108977
ARCN1 gene, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn training population the variables gender (men/women OR: 1.7, 95%CI: 1.237-2.5, P < 0.05), dyslipidemia (OR: 1.8, 95%CI: 1.2-2.5, P < 0.01) and smoking habit (OR: 1.5, 95%CI: 1.2-1.9, P < 0.001) were significantly associated with CAD in COPD patients, whereas in control population also age and diabetes were correlated.26111914
ProgeriaDeregulated Nutrient SensingAMPK-activating compounds including metformin and resveratrol may thus embody a novel treatment paradigm linking the pathophysiology of HGPS with that of HIV-1 latency.26115946
Dyslipidemias, Dysglycemia, Prediabetes syndromeDeregulated Nutrient SensingDietary habits and leisure-time physical activity in relation to adiposity, dyslipidemia, and incident dysglycemia in the pathobiology of prediabetes in a biracial cohort study.26116207
diabeticDeregulated Nutrient SensingHigh MPV quartiles were linearly associated with fasting glucose and glycated hemoglobin but not with diabetic duration or insulin resistance.26120789
Prediabetes syndrome, ObesityDeregulated Nutrient SensingWe report on the systemic levels of RBP4 and TTR and their associations with insulin resistance, obesity, prediabetes, and T2DM in Asian Indians.26121433
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingCirculatory levels of RBP4 and TTR showed a significant associations with glucose intolerance, obesity, T2DM and RBP4 additionally, with insulin resistance.26121433
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingIn mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin resistance.26122877
Parkinson Disease, VertigoDeregulated Nutrient SensingInvestigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease.26130063
Cessation of lifeDeregulated Nutrient SensingOur in vitro study suggests that SIRT1 function is inhibited by oxidative stress, which thereby promotes 6-hydroxydopamine-induced cell death.26130063
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most common comorbidities were hypertension (70.8%), dyslipidemia (36.7%) and diabetes (34%).26131698
ARCN1 gene, Primary malignant neoplasm, Dyslipidemias, Chronic Obstructive Airway Disease, Colorectal Carcinoma, Liver CirrhosisDeregulated Nutrient SensingBased on multivariate analysis among patients with CRC, age >=70 years, men, chronic obstructive pulmonary disease (COPD), cirrhosis, and dyslipidemia were independent predictors of an SPM.In conclusion, patients with CRC were at increased risk for a second cancer.26131831
ARCN1 gene, Dyslipidemias, Liver CirrhosisDeregulated Nutrient SensingAge, men, COPD, cirrhosis, and dyslipidemia were independent risk factors for SPMs.26131831
Overweight, Cardiovascular DiseasesDeregulated Nutrient SensingInfants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight.26132470
Pulmonary Embolism, DyslipidemiasDeregulated Nutrient SensingThe annual prevalence of ORCs ranged from 0.5% for pulmonary embolism (PE) to 41.8% for dyslipidemia.26134917
Hypertensive disease, Dyslipidemias, Degenerative polyarthritisDeregulated Nutrient SensingHypertensive diseases (HTND), dyslipidemia, and osteoarthritis were the three most expensive ORCs at the population level; each responsible for >=$18 million annually among 100,000 individuals.26134917
Diabetes MellitusDeregulated Nutrient SensingThe mix meal test suggested that APL patients with diabetes had a significant amount of functional pancreatic beta cells, and their diabetes was apparently associated with insulin resistance.26139569
DyslipidemiasDeregulated Nutrient SensingDyslipidemia patterns are differentially associated with dietary factors.26140958
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, a strong predictor of cardiovascular diseases, is prevalent among Korean adults, but little is known about the associations between overall lipid profiles and dietary factors.26140958
TG gene, CD55 gene, DyslipidemiasDeregulated Nutrient SensingTo identify dyslipidemia patterns, factor analysis was used based on total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), triglycerides (TG), and high-density lipoprotein cholesterol (HDLC).26140958
TG gene, DyslipidemiasDeregulated Nutrient SensingTwo dyslipidemia patterns, (1) TC & LDLC and (2) TG & HDLC, were identified.26140958
DyslipidemiasDeregulated Nutrient SensingTwo dyslipidemia patterns were associated with dietary factors in Korean adults.26140958
Obesity, AbdominalDeregulated Nutrient Sensing* Insulin resistance was found to be the only significant laboratory predictor of MUO when adjusted for gender, puberty, and the degree of abdominal obesity.26141171
Atherosclerosis of renal arteryDeregulated Nutrient SensingMetformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction.26141671
Metabolic DiseasesDeregulated Nutrient SensingThis implies that subjects with an increasing degree of insulin resistance are more likely to not engage in muscular strengthening activity, an exercise modality that has been shown to reduce the risk of several cardiometabolic diseases and improve glycaemic status.26141966
Dyslipidemias, Diabetes Mellitus, Congestive heart failure, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingConfounding factors affecting ICVA risk were recorded: age, diabetes, hypertension, peripheral vascular disease, dyslipidemia, and congestive cardiac failure.26142261
Hyperglycemia, Pyoderma, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingThese were localization of the pyogenic process in the larynx, abdominal obesity, fasting hyperglycemia in excess of 8.3 mmol/l, and dyslipidemia accompanied by the reduction in the amount of high density lipoproteins to below 40 mg/100 ml and the increase of low density lipoproteins to above 155 mg/100 ml.26145741
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe I148M variant, although increasing the risk of NAFLD, was associated with reduced levels of central adiposity, BMI, serum triglycerides and insulin resistance, suggesting differential roles in fat storage and distribution according to cell types and metabolic status.26148225
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSecondary diagnoses: Diabetes Mellitus 64%, high blood pressure 77%, dyslipidemia 52%.26150030
Diabetes MellitusDeregulated Nutrient SensingExplaining psychological insulin resistance in adults with non-insulin-treated type 2 diabetes: The roles of diabetes distress and current medication concerns.26150327
Anxiety, CTCAE 3.0, Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingPsychological insulin resistance may reflect broader distress about diabetes and concerns about its treatment but not general beliefs about medicines, depression or anxiety.26150327
Proteinuria, Hypertension, CTCAE, Complications of Diabetes Mellitus, DyslipidemiasDeregulated Nutrient SensingIt is also essential to detect early, monitor and manage proteinuria, hypertension and dyslipidemia with good glycemic control to prevent diabetes complications.26152133
Fatty LiverDeregulated Nutrient SensingAging is accompanied by pathophysiological changes including insulin resistance and fatty liver.26152236
Congenital AbnormalityDeregulated Nutrient SensingOn the basis of the well-known key roles of 5'-adenosine monophosphate-activated protein kinase (AMPK) in sensing and regulating the intracellular energy status, we hypothesized that mice with a genetic deletion of AMPK would develop locomotor abnormalities that bear similarity with those detected in the very early disease stage of mice carrying the ALS-associated mutated gene hSOD1(G93A).26152932
Amyotrophic Lateral Sclerosis, Molecular AbnormalityDeregulated Nutrient SensingTaken together, these data support the concept that altered AMPK function and associated bioenergetic abnormalities could constitute an important component in the early pathogenesis of ALS.26152932
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingA Trial of Pitavastatin Versus Rosuvastatin for Dyslipidemia in Chronic Kidney Disease.26156625
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEpidemiologic data suggest that low serum 25-hydroxyvitamin D [25(OH)D] increases insulin resistance and the risk of type 2 diabetes.26156733
Hypertension, CTCAE, OverweightDeregulated Nutrient SensingNormal-weight, overweight, and obese adults were considered "healthy" if they had <2 of the following risk factors: low HDL cholesterol, hypertension, high blood glucose, high triacylglycerol, and insulin resistance.26156738
Diabetes MellitusDeregulated Nutrient SensingCopeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men.26158609
Friedreich AtaxiaDeregulated Nutrient SensingTORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia.26158631
Friedreich AtaxiaDeregulated Nutrient SensingWe found that genetic reduction in TOR Complex 1 (TORC1) signalling improves the impaired motor performance phenotype of FRDA model flies.26158631
Friedreich AtaxiaDeregulated Nutrient SensingThese results point to the TORC1 pathway as a new potential therapeutic target for FRDA and as a guide to finding new promising molecules for disease treatment.26158631
Amyotrophic Lateral Sclerosis, DyslipidemiasDeregulated Nutrient SensingThe aim of this study was to examine the prevalence of dyslipidaemia among a cohort of patients with ALS and how the lipid profile of patients with ALS influenced the prognosis.26161993
Diabetes MellitusDeregulated Nutrient SensingInteractions with diabetes and insulin resistance may explain divergent findings on how estrogen influences brain volume among older women.26163429
Hyperglycemia, ObesityDeregulated Nutrient SensingThe mechanism by which maternal obesity leads to these outcomes is not well understood, but maternal hyperglycaemia and insulin resistance are both implicated.26165398
Nonalcoholic Steatohepatitis, Non-alcoholic Fatty Liver Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are strongly associated with obesity, insulin resistance, and type 2 diabetes.26166101
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is one of the most important independent modifiable risk factors for cardiovascular diseases.26168792
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingPresence of dyslipidemia was significantly associated with increasing age, smoking status, hypertension, diabetes, and body mass index.26168792
DyslipidemiasDeregulated Nutrient SensingHigh prevalence of dyslipidemia with relative low awareness in Shenzhen was found.26168792
Dyslipidemias, RestenosisDeregulated Nutrient SensingIn-stent restenosis was associated with younger patient age and with dyslipidemia, long lesion, and stent length.26169015
Muscle hypertrophyDeregulated Nutrient SensingSkeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling.26169934
Mucopolysaccharidosis IDeregulated Nutrient SensingCritically, whereas MPS remained unchanged in the UT leg (e.g., ~1.35 +- 0.08%/d), the T leg exhibited increased MPS at 0-3 wk (1.6 +- 0.01%/d), but not at 3-6 wk (1.29 +- 0.11%/d); this was reflected by dampened acute mechanistic target of rapamycin complex 1 signaling responses to RET, beyond 3 wk.26169934
Muscle (organ)Deregulated Nutrient SensingYoung and lean men from rural India with low birth weight were not observed to have ectopic fat storage in the liver or muscle, and the amount of liver and muscle fat was unrelated to insulin resistance.26172248
Choroidal NeovascularizationDeregulated Nutrient SensingSIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.26174951
Primary malignant neoplasm, CC-223Deregulated Nutrient SensingThis phase 1 study investigated the mTORC1/mTORC2 inhibitor CC-223 in patients with advanced cancer.26177599
CC-223Deregulated Nutrient SensingPhosphorylation of mTORC1/mTORC2 pathway biomarkers in blood cells was inhibited by CC-223 >=30 mg/d with an exposure-response relationship.26177599
NeoplasmsDeregulated Nutrient SensingPreliminary antitumor activity, including tumor regression, and evidence of mTORC1/mTORC2 pathway inhibition were observed.26177599
Dyslipidemias, ETV3 wt Allele, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingCompared with the controls, the MetS patients showed significantly lower levels of mean strain, mean peak systolic SR and mean peak early diastolic SR (P<0.001 for all), with no difference in the mean peak late diastolic SR. Central obesity, hypertension, dyslipidemia and LV diastolic abnormality were independent risk factors for impaired LA function.26178155
Renal Insufficiency, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingHypothyroidism was confirmed to be associated with both dyslipidemia and renal dysfunction.26179571
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLow vitamin D status has been associated with an increased risk of developing type 2 diabetes and insulin resistance (IR), although this has been recently questioned.26180247
Amyloidosis, Dyslipidemias, GlomerulonephritisDeregulated Nutrient SensingUnknown aspect of the old disease: does dyslipidemia in systemic AA amyloidosis differ from the dyslipidemia in primary glomerulonephritis?26181645
Dyslipidemias, AmyloidosisDeregulated Nutrient SensingTo investigate the nature of dyslipidemia and its diversity in patients with systemic AA amyloidosis.26181645
Dyslipidemias, AmyloidosisDeregulated Nutrient SensingAlthough the frequency of dyslipidemia was similar in the groups (86.0 vs. 93.4%), patients with systemic amyloidosis had both lower values of LDL-C (4.56 +- 2.05 vs. 5.49 +- 2.23 mmol/L, p = 0.028) and HDL-C (1.19 +- 0.36 vs. 1.35 +- 0.39 mmol/L, p = 0.035).26181645
Proteinuria, Dyslipidemias, AmyloidosisDeregulated Nutrient SensingAlthough dyslipidemia is closely associated with serum total protein, albumin and proteinuria in patients with PG, there is no clear such association in patients with systemic amyloidosis.26181645
Dyslipidemias, Amyloidosis, Nephrotic SyndromeDeregulated Nutrient SensingCorrelation between serum lipid and hemoglobin levels in this group and other findings point out that probably complex mechanisms take place in dyslipidemia of nephrotic syndrome caused by systemic AA amyloidosis.26181645
Glucose Intolerance (disease), Cardiovascular DiseasesDeregulated Nutrient SensingHIV-infected patients should be monitored for glucose intolerance, but statins should not be withheld if clinically indicated for cardiovascular disease risk reduction.26181706
Acromegaly, physiopathologicalDeregulated Nutrient SensingIn acromegaly visfatin could be considered a useful index of disease activity and metabolic alterations, such as insulin resistance and adipose dysfunction, regardless of the type of treatment.26188992
Food InsecurityDeregulated Nutrient SensingGender differences in the association between food insecurity and insulin resistance among U.S. adults: National Health and Nutrition Examination Survey, 2005-2010.26189664
OverweightDeregulated Nutrient SensingInsulin resistance was higher in both normal-weight (P = .001) and overweight or obese (P < .001) women with lower food security, but no linear trend was found in men.26189664
Food InsecurityDeregulated Nutrient SensingIn women, the association between food insecurity and insulin resistance was no longer significant after adjustment.26189664
Overweight, Diabetes MellitusDeregulated Nutrient SensingFood insecurity is associated with insulin resistance in adults without diabetes, and this effect varies by gender in normal-weight and overweight or obese populations.26189664
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingImproving food security status may help reduce insulin resistance, an underlying risk factor for diabetes and cardiovascular disease.26189664
Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism.26190559
Liver damage, Dyslipidemias, ObesityDeregulated Nutrient SensingCorrecting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage.26190559
Hyperinsulinism, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingHigh-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease.26190559
Hypertension, CTCAEDeregulated Nutrient SensingEstimated GFRcr-cys, but not eGFR based on creatinine, was predicted by insulin resistance and hypertension and positively correlated with CVD.26194503
Dyslipidemias, ObesityDeregulated Nutrient SensingControl of preventable risk factors such as smoking, unhealthy diet, obesity and dyslipidemia should be reinforced at an early age in Bangladesh.26197888
Heart failureDeregulated Nutrient SensingInsulin resistance in heart failure: differences between patients with reduced and preserved left ventricular ejection fraction.26198713
Heart failureDeregulated Nutrient SensingInsulin resistance (IR) is a characteristic feature of heart failure (HF) pathophysiology that affects symptoms and mortality.26198713
Suicidal behavior, Bipolar DisorderDeregulated Nutrient SensingInsulin resistance and disturbances in glucose and lipid metabolism may be more common in middle-aged depressive patients with suicidal behaviour.26199013
Obesity, AbdominalDeregulated Nutrient SensingLower adiponectin levels were related to gender, abdominal obesity, physical activity and insulin resistance and were less influenced by the polymorphisms studied.26199115
Weight Gain, DyslipidemiasDeregulated Nutrient SensingWhile heavier weight is known to increase the incidence of dyslipidemia, limited data are available on the relationship between weight gain and its development.26199305
Weight Gain, DyslipidemiasDeregulated Nutrient SensingThese results suggest that dyslipidemia could be prevented by avoiding weight gain in adulthood.26199305
Glucose Intolerance (disease)Deregulated Nutrient SensingTo characterize the association between REM-related SDB, glucose intolerance, and insulin resistance in a community-based sample.26200994
Glucose Intolerance (disease), Blood GlucoseDeregulated Nutrient SensingAHIREM is associated with insulin resistance but not with fasting glycemia or glucose intolerance.26200994
Structure of posterior cerebral arteryDeregulated Nutrient SensingWhen stratified by metformin use, IGF-1R remained significantly elevated (P = 0.01) in men with PCa detected whereas p-AMPK (P = 0.05) was elevated only in those without PCa.26201966
Colorectal CarcinomaDeregulated Nutrient SensingGene polymorphisms related to insulin resistance and gene-environment interaction in colorectal cancer risk.26203767
Colorectal CarcinomaDeregulated Nutrient SensingInsulin resistance (IR) is an established risk factor for colorectal cancer (CRC) and both IR and CRC physiologically overlap.26203767
Cardiovascular Diseases, Carotid Intima-Media Thickness, Uterine FibroidsDeregulated Nutrient SensingThe aim of this study was to investigate the cardiovascular disease risk of patients with uterine leiomyoma using carotid intima-media thickness (CIMT), insulin resistance and lipid profile.26208583
Uterine FibroidsDeregulated Nutrient SensingUterine leiomyoma was associated with lipid profile, insulin resistance and CIMT in reproductive-aged women.26208583
Lung diseasesDeregulated Nutrient SensingMoreover, we observed that BET inhibition functionally reversed the pro-inflammatory effect of SIRT1 inhibition in a cellular lung disease model.26212199
Muscle, Smooth, VascularDeregulated Nutrient SensingTo date, the impact of endogenous glycogen depletion in vascular smooth muscle and the resultant alterations in cellular energy state (e.g., AMP-activated protein kinase, AMPK) on the contractile response to G protein-coupled receptor agonists (e.g., serotonin, 5-HT) has not yet been studied.26212549
Myocardial IschemiaDeregulated Nutrient SensingTogether, the present findings from clinically-relevant human saphenous vein suggest that the loss of endogenous glycogen in vascular smooth muscle and the resultant accentuation of AMPK phosphorylation by GPCR agonists may constitute a yet another mechanism of metabolic vasodilation of coronary vessels in ischemic heart disease.26212549
SLC25A20 gene, DyslipidemiasDeregulated Nutrient SensingHigh CAC scores were associated with male gender, aging, dyslipidemia, and fasting glucose.26213250
Alzheimers DiseaseDeregulated Nutrient SensingAssociation of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.26214150
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingHence early diagnosis and monitoring of dyslipidemia and treatment of the high risk group with anti hyperlipidemic drugs will help to prevent the incidence of cerebral ischemic stroke thereby reducing morbidity and mortality.26215001
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingTwenty-one patients (63.6%) had hypertension, 17 (51.5%) dyslipidemia, and 7 (21.2%) had type 2 diabetes or impaired glucose tolerance.26215278
Hepatitis CDeregulated Nutrient Sensingn-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial.26216648
Hepatobiliary Disorder, Hepatitis CDeregulated Nutrient SensingInsulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients.26216648
Hepatitis CDeregulated Nutrient Sensingn-3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients.26216648
Diabetes MellitusDeregulated Nutrient SensingA number of peroxisome proliferator-activated receptor (PPAR) a/g dual agonists have been tested for their abilities to attenuate insulin resistance and type 2 diabetes.26219845
Dyslipidemias, Diabetes Mellitus, Overweight, Hypertension, CTCAE, Polycystic Ovary SyndromeDeregulated Nutrient SensingDyslipidemia often affects overweight and obese adolescents and can be present along with hypertension, insulin resistance, type 2 diabetes, and polycystic ovarian syndrome.26219905
Dyslipidemias, OverweightDeregulated Nutrient SensingDyslipidemia in Overweight and Obese School-Aged Children.26219905
Dyslipidemias, ObesityDeregulated Nutrient SensingThis article is the third of six discussing the comorbidities of childhood obesity and will focus on the individual parts of the lipid profile and the impact of dyslipidemia on the heart and other body systems.26219905
Colorectal CarcinomaDeregulated Nutrient SensingAspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells.26219912
Colorectal CarcinomaDeregulated Nutrient SensingAspirin increased the senescence of CRC cells, increased the protein levels of SIRT1, phospho-AMPK (T172), and phospho-acetyl CoA carboxylase (S79), and reduced the cellular level of ATP.26219912
Colorectal CarcinomaDeregulated Nutrient SensingSmall-interfering RNA-mediated downregulation or pharmacological inhibition of SIRT1 or AMPK significantly attenuated the aspirin-induced cellular senescence in CRC cells.26219912
Colorectal CarcinomaDeregulated Nutrient SensingDuring the progression of aspirin-induced cellular senescence in CRC cells, SIRT1 showed increased deacetylase activity at a relatively early time point but was characterized by decreased activity with increased cytoplasmic localization at a later time point.26219912
Rheumatoid ArthritisDeregulated Nutrient SensingThe role of methotrexate and low-dose prednisolone on adiponectine levels and insulin resistance in patients with rheumatoid arthritis naive to disease-modifying antirheumatic drugs.26222244
Refractory anemias, Rheumatoid ArthritisDeregulated Nutrient SensingInsulin resistance (IR) plays an important role in the development of cardiovascular events in rheumatoid arthritis (RA) patients.26222244
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance.26222846
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes (T2D) affects ~10% of the US population, a subset of whom have severe insulin resistance (SIR) (>200 units/d).26222846
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingCardiovascular risk factors were common: hypertension 31.3% (n = 90), diabetes mellitus 10.5% (n = 29), smoking 21.8% (n = 61), obesity 27.6% (n = 69), dyslipidaemia 22.4% (n = 65), family history 8.5% (n = 24), antiretroviral therapy 12.2% (n = 36).26222883
AdenomaDeregulated Nutrient SensingNonlinear dose responses were observed for AMPK and mechanistic target of rapamycin (mTOR) signaling in mouse adenoma cells, culminating in autophagy and senescence.26223300
Kidney Diseases, Lipid Metabolism DisordersDeregulated Nutrient SensingDifferences in median total all-cause health care costs observed for diabetes/insulin resistance management (US$14,547 median all-cause health care costs during time periods identified as diabetes/insulin resistance medical events versus US$11,237 without diabetes/insulin resistance events; P=.0021), lipid disorders (US$12,825 versus US$10,033; P=.0004), and renal disorders (US$1389 versus US$0; P<.0001).26224690
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingArterial hypertension, insulin resistance, and dyslipidemia is more strongly correlated to waist circumference in boys.26226893
Inflammation, MalnutritionDeregulated Nutrient SensingThe results of this study suggest that plasma TNF-a is associated with inflammation and insulin resistance in both Japanese elderly men and women, and a prominent association of TNF-a with malnutrition status was observed in elderly women.26226964
DyslipidemiasDeregulated Nutrient SensingNew Fixed-Dose Combinations of Fenofibrate/Simvastatin Therapy Significantly Improve the Lipid Profile of High-Risk Patients with Mixed Dyslipidemia Versus Monotherapies.26227087
TG gene, DyslipidemiasDeregulated Nutrient SensingFDC fenofibrate/simvastatin are effective and well-tolerated therapies to improve the TG and HDLC profile in high-risk patients with mixed dyslipidemia.26227087
DyslipidemiasDeregulated Nutrient SensingResidual dyslipidemia according to low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B among statin-treated US adults: National Health and Nutrition Examination Survey 2009-2010.26228670
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingDespite being on treatment, many persons with dyslipidemia still have suboptimal lipid levels and still experience cardiovascular disease (CVD) events.26228670
DyslipidemiasDeregulated Nutrient SensingDespite statin treatment, many persons continue to have residual dyslipidemia with LDL-C, non-HDL-C, and/or apoB levels not being at recommended levels.26228670
Dyslipidemias, Diabetic Foot, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingDetections of cardiovascular disease risk factors (dyslipidemia and hypertension) were the indicators with the highest improvement, while non-pharmaceutical treatment and diabetic foot exams showed minor changes.26230991
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThis relationship is independent of diabetes, hypertension, dyslipidemia, and body mass index.26231617
Dyslipidemias, Have Dizziness, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingSerum and urine levels of UCH-L1 were assessed in 125 patients with dizziness, hypertension, type 2 diabetes mellitus, or dyslipidemia.26232084
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAfter adjustment for obesity, there was no difference in hypertension, dyslipidemia, diagnosed diabetes, or smoking between veteran and non-veteran men.26232905
Glucose Intolerance (disease), MalnutritionDeregulated Nutrient SensingWe report a case of pancreatolithiasis in which glucose intolerance and malnutrition were significantly improved after starting oral litholysis therapy (OLT) with use of trimethadione.26233654
Glucose Intolerance (disease), MalnutritionDeregulated Nutrient SensingIn addition, both glucose intolerance and insulin secretion were significantly ameliorated, followed by improvement of malnutrition.26233654
Heart failureDeregulated Nutrient SensingReduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure.26233702
Chemical injuryDeregulated Nutrient SensingSirtuin-1 (SIRT1) is a longevity factor in mammals initiating the cell survival mechanisms, and preventing ischemic injury in heart.26233702
Pentalogy of CantrellDeregulated Nutrient SensingWith SIRT1 expression levels, TAS, TOS, OSI, and high density lipoprotein levels in cHF and dHF were determined correlated.26233702
Hemorrhage, DyslipidemiasDeregulated Nutrient SensingGender, dyslipidaemia, prior percutaneous coronary intervention, prior use of acenocoumarol and concomitant coronary artery bypass grafting were found to be predictors for bleeding events.26233944
ObesityDeregulated Nutrient SensingAdiponectin is an adipokine which is known to decrease in individuals associated with obesity and insulin resistance.26234224
Prediabetes syndrome, Chronic disease, Diabetes MellitusDeregulated Nutrient SensingPatients with a known state of insulin resistance, including prediabetes and overt diabetes, and individuals with chronic diseases were excluded.26234224
Increased insulin level, Hypertensive (finding)Deregulated Nutrient SensingCarotid artery stiffness is related to hyperinsulinemia and insulin-resistance in middle-aged, non-diabetic hypertensive patients.26234565
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe study population comprised 2,354 individuals with dyslipidemia (hypertriglyceridemia, hypo-HDL-cholesterolemia or hyper-LDL-cholesterolemia) and 3,106 control individuals.26238946
Diabetes MellitusDeregulated Nutrient SensingAdditionally, the impact of insulin resistance on metabolic profile can differ by gender and racial group, suggesting that gender-race specific prediction algorithms for diabetes may be warranted.26241327
OverweightDeregulated Nutrient SensingInteraction with pBMI was observed in the associations with insulin resistance markers: in offspring of overweight mothers (>=25.0 kg/m2), a 10 nmol/L increase in maternal 25OHD was associated with a 0.007(99%CI:-0.01,-0.001) nmol/L decrease in C-peptide and a 0.02(99%CI:-0.03,-0.004) decrease in HOMA2-IR.26244505
OverweightDeregulated Nutrient SensingThus, intrauterine exposure to both low 25OHD and maternal overweight may be associated with increased insulin resistance in offspring, while exposure to low 25OHD in utero may be associated with increased offspring %BF with no interactive effects from pBMI.26244505
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe trial will provide much needed clinical evidence on the impact of vitamin D supplementation on insulin resistance and secretion and its underlying mechanisms, which are relevant for the prevention and management of type 2 diabetes.26246241
Heart Diseases, Dyslipidemias, diabetic, Cerebrovascular accidentDeregulated Nutrient SensingAnalysis also showed that 60.4% were diabetic, 8.9% had a stroke history, 74.3% had dyslipidemia, 69.8% were obese and 30.9% had a history of heart disease.26246311
Pancreatic Neoplasm, NeoplasmsDeregulated Nutrient SensingSurgically reversible blood glucose dysregulation diagnosed concomitantly with a (peri-) pancreatic tumor appears secondary to compromised liver function due to tumor compression of the common bile duct and the subsequent increase in insulin resistance.26248027
Dyslipidemias, Diabetes Mellitus, Hormone abnormality, ovarian neoplasm, Psychiatric, Hypertension, CTCAEDeregulated Nutrient SensingPatients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03).26248245
Malignant neoplasm of liver, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance among participants without diabetes at baseline was associated with hepatocellular cancer mortality (HR 4.70; 95% CI 1.55-14.26).26250516
Hepatocellular, Prostate carcinoma, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, and/or insulin resistance among those without diabetes, is a risk factor for gastric, hepatocellular, and prostate cancer in these American Indian communities, although relatively small sample size suggests cautious interpretation.26250516
Cardiovascular DiseasesDeregulated Nutrient SensingOur results indicate that metformin intake activates AMPK and consequently suppresses FADS, which leads to reduced levels of the three acyl-alkyl PCs and LDL-C. Our findings suggest potential beneficial effects of metformin in the prevention of cardiovascular disease.26251408
Steatohepatitis, Fatty degeneration, DyslipidemiasDeregulated Nutrient SensingComparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002).26252778
Steatohepatitis, Muscle (organ), Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.26252778
Inflammation, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingApoptotic markers and DNA damage are related to late phase of stroke: Involvement of dyslipidemia and inflammation.26253215
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHowever, little is known about these events and markers in the late stroke (>6 months) and if dyslipidemia could contribute to disease's pathophysiology in a later phase.26253215
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingMoreover, we observed that stroke patients with dyslipidemia had significantly higher TNF-a, CASP 8 and CASP 3 levels than stroke without dyslipidemia and control groups.26253215
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingFurthermore, it is plausible to propose that dyslipidemia may contribute to worsen proinflammatory state in a later phase of stroke and an increased risk to new neurovascular events.26253215
Endothelial dysfunctionDeregulated Nutrient SensingThe relatively common TRIB3 Q84R polymorphism (rs2295490) has been associated with abnormal insulin signaling, endothelial dysfunction, insulin resistance, and pro-atherogenic phenotypes.26253791
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of major comorbidities in patients undergoing EVAR, including obesity, diabetes, and dyslipidemia, all increased significantly over time.26254455
Inflammation, hepcidinDeregulated Nutrient SensingBy comparing quartiles of hepcidin levels, systolic blood pressure values in men were significantly higher in the upper quartile of hepcidin vs. the rest of quartiles independently of BMI, chronic inflammation, insulin resistance and other iron markers (ANCOVA, p <0.05).26254700
InflammationDeregulated Nutrient SensingFatty liver (FL) and abdominal visceral fat (AVF) are strongly associated with systemic inflammation, however, it has not been defined if each one is independently involved, and if the insulin resistance is associated.26256894
Coronary Artery DiseaseDeregulated Nutrient SensingTo investigate if FL, AVF and insulin resistance are independently or additively associated with the high-sensitivity C-reactive protein (hs-CRP) in subjects without coronary artery disease we included 491 men and 553 women.26256894
Inflammation, Dyslipidemias, OsteoporosisDeregulated Nutrient SensingInflammation, insulin resistance, dyslipidemia, and glucagon-like peptide-1 (GLP-1) are risk factors for osteoporosis.26259132
InflammationDeregulated Nutrient SensingThe mechanisms may be partly explained by the effect of DPP4 on inflammation and insulin resistance.26259132
Hypertension, CTCAEDeregulated Nutrient SensingExperimental studies suggest that a higher intra-cellular ratio of Ca:Mg, which may be induced by a diet high in Ca and low in Mg, may lead to hypertension and insulin resistance.26259506
TG gene, Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingEven with treatment for hyperglycemia and dyslipidemia, overall levels of fasting blood sugar (FBG, P<0.001), GHbA1c (P<0.001), and triglycerides (TG, P<0.05) in patients with diabetes were still higher than those without diabetes respectively.26261612
Dyslipidemias, ObesityDeregulated Nutrient SensingAssociation of NCOA2 gene polymorphisms with obesity and dyslipidemia in the Chinese Han population.26261634
ObesityDeregulated Nutrient SensingInsulin resistance and obesity were associated with both definitions.26268091
Diastolic dysfunction, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingIn multivariable analysis, the presence of diastolic dysfunction on echocardiogram was significantly associated with an abnormal calcium score (OR 13.82, 95% CI 5.57 to 37.37; p < 0.001) after adjusting for Framingham Risk Score or clinical risk factors (age, gender, diabetes mellitus, dyslipidemia, and obesity; OR 19.06,95% CI 4.66 to 107.97; p < 0.001).26269148
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome XDeregulated Nutrient SensingThe liver as central metabolic organ is not only affected by the metabolic syndrome as non-alcoholic fatty liver disease (NAFLD), but may contribute to insulin resistance and metabolic alterations.26269425
Total Peripheral ResistanceDeregulated Nutrient SensingThese results suggest a greater level of peripheral insulin-resistance is associated with decreased cognitive control and working memory.26272269
Alzheimers DiseaseDeregulated Nutrient SensingPeripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients.26275347
Data types - AddressDeregulated Nutrient SensingSirtuin 1 (Sirt1) serum levels are lower in AD patients and Presenilin 1 (Psen1) is expressed by blood cells.26275347
Data types - AddressDeregulated Nutrient SensingIn conclusion, this study shows that peripheral levels of the potential AD biomarker proteins Bdnf, Sirt1, and Psen1 are not regulated by different promoter methylation.26275347
Impaired cognitionDeregulated Nutrient SensingInsulin resistance occurring during midlife may increase the risk of cognitive decline later in life.26276262
Dyslipidemias, Angina PectorisDeregulated Nutrient SensingObese undergoing TX had more dyslipidemia (46% vs. 31%), angina (23% vs. 14%), MI (18% vs. 5%), increased total cholesterol (185 +- 56 vs. 172 +- 48), and triglycerides (237 +- 190 vs. 149 +- 100).26277344
Diabetes Mellitus, Non-Insulin-Dependent, physiopathologicalDeregulated Nutrient SensingType 2 diabetes is a progressive disease characterized by insulin resistance and insulin secretory dysfunction.26278286
B-Lymphocytes, Toxic effectDeregulated Nutrient SensingEnvironmental factors causing insulin resistance and glucotoxicity may therefore be involved in progressive b-cell failure.26278286
Fatty Liver Disease, Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingNon-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes.26278350
Neoplasm Metastasis, Breast CarcinomaDeregulated Nutrient SensingExpression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer.26280894
Neoplasm Metastasis, Breast CarcinomaDeregulated Nutrient SensingWe aimed to construct a biomarker-based model that predicts lymph node metastasis in luminal A breast cancer, using expression of silent mating type information regulation 2 homolog 1 (SIRT1) and apoptosis-related factors, which are known to be closely related.26280894
Ductal CarcinomaDeregulated Nutrient SensingWe selected tissue samples of 278 cases of luminal A invasive ductal carcinoma, constructed tissue microarrays, and performed immunohistochemical staining for SIRT1 and four apoptosis-related proteins.26280894
Neoplasm MetastasisDeregulated Nutrient SensingIndependent factors predictive of lymph node metastasis were pT stage (OR 1.829, p = 0.027), lymphovascular invasion (OR 4.128, p < 0.001), and decreased expression of caspase-3 (OR 0.535, p = 0.034) and of SIRT1 (OR 0.526, p = 0.053).26280894
Neoplasm Metastasis, B-Cell LymphomasDeregulated Nutrient SensingA combination nuclear grade, lymphovascular invasion, increased B-cell lymphoma 2 (Bcl-2) expression, and reduced expression of caspase-3 and of SIRT1 yielded the strongest predictive performance for lymph node metastasis with an area under the curve (AUC) of 0.696.26280894
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingOur data support a role of SIRT1 protein as tumor suppressor in luminal A breast cancer, in association with apoptosis-related proteins.26280894
Demographics DomainDeregulated Nutrient SensingThe risk of DM significantly increased with increasing baseline GGT after adjusting for confounders such as BMI, alcohol drinking, 2 hr PG and insulin resistance (2.02[1.35-3.02]; P = 0.001).26281475
HyperglycemiaDeregulated Nutrient SensingIsolated hyperglycemia is associated with higher serum concentrations of TGF-b, while a broader phenotype of insulin resistance is associated with higher serum PIIINP.26282733
Dyslipidemias, Diabetes Mellitus, Hyperuricemia, ObesityDeregulated Nutrient SensingPatients with obesity, dyslipidemia (P < 0.05, respectively), diabetes or hyperuricemia (P < 0.01, respectively) had significantly higher expression of NLRP3.26282945
Congenital AbnormalityDeregulated Nutrient SensingElevated cortisol levels and dysregulated insulin-like growth factor binding protein-1 (IGFBP-1; a marker of hepatic insulin sensitivity) are both related to insulin resistance and glucose abnormalities.26283275
Fibrosis AssessmentDeregulated Nutrient SensingThe DF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional b-Cell Mass in Mice.26283735
Hypertensive (finding)Deregulated Nutrient SensingThe effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population.26284905
TG gene, DyslipidemiasDeregulated Nutrient SensingThe prevalence of hyper LDL-C, hyper TG, and hypo HDL-C were 29.3, 24.2, and 10.2%, respectively, and the overall prevalence of dyslipidemia was 56.5%.26292631
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia in Japanese patients with RA is higher than that in the non-RA population.26292631
Refractory anemias, Dyslipidemias, DiseaseDeregulated Nutrient SensingLow-dose atorvastatin was effective for treatment of dyslipidemia in RA patients but had no apparent effect on RA disease activity.26292631
Immunoglobulin M, HyperglycemiaDeregulated Nutrient SensingThe observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM.26294793
DyslipidemiasDeregulated Nutrient SensingPA patients had a higher risk of postoperative new-onset or progressive dyslipidemia.26296835
Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Hypertension, CTCAEDeregulated Nutrient SensingCompared with the non-hyperuricemia group (n = 170), the hyperuricemia group (n = 254) had a higher prevalence of hypertension (P = 0.013), diabetes mellitus (P = 0.01), dyslipidemia (P = 0.038), atrial fibrillation (P = 0.001), and use of diuretics (P < 0.001).26297226
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe explored the prevalence of and risk factors for type 2 diabetes in the adult population of Shanghai (China) with and without dyslipidemia.26297334
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe incidences of hypertension, diabetes mellitus, and dyslipidemia were 51.2, 19.4, and 22.2%, respectively.26298315
Inflammation, ObesityDeregulated Nutrient SensingThrombospondin 1 (THBS1 or TSP-1) is an adipose-derived matricellular protein, which has recently been highlighted as a potential mediator of insulin resistance and adipose inflammation in obesity.26298466
Rheumatoid ArthritisDeregulated Nutrient SensingRegulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts.26298564
ArthritisDeregulated Nutrient SensingHowever, deletion of SIRT1 aggravated inflammatory arthritis in mice and increased production of pro-inflammatory cytokines in murine macrophages.26298564
Refractory anemiasDeregulated Nutrient SensingIn the current study, we investigated the regulation, expression, and function of SIRT1 in RA, in particular its role in adhesion and proliferation of human RA synovial fibroblasts (RASF).26298564
Refractory anemiasDeregulated Nutrient SensingWe found that expression of SIRT1 was increased in vivo in synovial tissues of RA smokers and in vitro by stimulation of RASF with TNFa, but decreased upon treatment with cigarette smoke extract.26298564
Refractory anemiasDeregulated Nutrient SensingSynovial tissues of RA smokers showed higher leukocytic infiltration that positively correlated with enhanced levels of SIRT1.26298564
Refractory anemiasDeregulated Nutrient SensingIn conclusion, SIRT1 modulates the proliferative and potentially also adhesive properties of RASF and can therefore promote progression of RA.26298564
Refractory anemiasDeregulated Nutrient SensingUpregulation of SIRT1 in RA smokers correlates with increased leukocytic infiltration.26298564
InflammationDeregulated Nutrient SensingSIRT1 modulates expression of genes regulating cell adhesion and inflammation.26298564
Abnormality of the endocrine system, Thyroid Diseases, DyslipidemiasDeregulated Nutrient SensingPrevalence of any endocrine abnormality was 58% (dyslipidaemia 43%, glucose intolerance/T2DM 13%, thyroid disorders 15%).26300027
Degenerative polyarthritis, Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingAssociation Between Physical Therapy and Risk of Coronary Artery Disease and Dyslipidemia Among Osteoarthritis Patients: A Nationwide Database Study.26301384
Degenerative polyarthritis, DyslipidemiasDeregulated Nutrient SensingAfter adjusting for other potential confounders, the Cox proportional hazards regression analysis showed that patients with OA who received a high PT dosage had a low risk of CAD and dyslipidemia.26301384
Degenerative polyarthritis, DyslipidemiasDeregulated Nutrient SensingPatients with OA who received PT had a lower risk of OA-related comorbidities such as dyslipidemia or CAD.26301384
Metabolic Syndrome X, Cardiovascular DiseasesDeregulated Nutrient SensingMetabolic syndrome is associated with impaired vascular endothelial function, insulin resistance, and increased risk for cardiovascular disease but the underlying mechanisms are not fully elucidated.26302093
BlockingDeregulated Nutrient SensingInsulin resistance also did not change following MR blockade (1.04 +- 0.26 vs. 1.38 +- 0.50; P = 0.6).26302093
ObesityDeregulated Nutrient SensingIncreasing evidence suggests that overnutrition during the early postnatal period, a critical window of development, increases the risk of adult-onset obesity and insulin resistance.26302954
Glucose Intolerance (disease)Deregulated Nutrient SensingThey had increased visceral fat mass, adult-onset insulin resistance and glucose intolerance as well as elevated serum levels of free fatty acids and triglycerides.26302954
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe prevalence of mixed dyslipidemia and severe hypertriglyceridemia in the Russian population (PROMETHEUS) was undertaken to address this gap.26303403
Glucose Intolerance (disease), Hypertension, CTCAEDeregulated Nutrient SensingIn a univariate analysis, hypertension, previous IS, glucose intolerance, pulse pressure above median, and presence of moderate to extensive cSVD were associated with the NR phenotype.26303791
Arterial Stiffness, Cardiovascular DiseasesDeregulated Nutrient SensingAssociation of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.26308091
Liver carcinoma, Neoplasm MetastasisDeregulated Nutrient SensingAberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.26308575
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingAberrant mTORC1 signaling is common in hepatocellular carcinoma (HCC), but the underlying mechanism remains elusive.26308575
Neoplasm Metastasis, Hyperactive behavior, Malignant Neoplasms, FAM126A geneDeregulated Nutrient SensingWe found that Rab1A is frequently overexpressed in HCC, which enhances hyperactive AA-mTORC1 signaling, promoting malignant growth and metastasis of HCC in vitro and in vivo.26308575
Malignant neoplasm of liverDeregulated Nutrient SensingOur findings further suggest that Rab1A is a valuable biomarker for prognosis and personalized mTORC1-targeted therapy in liver cancer.26308575
FAM126A geneDeregulated Nutrient SensingBecause liver is a physiological hub for nutrient sensing and metabolic homeostasis, we investigated the possible role of Rab1A in HCC.26308575
Hepatitis CDeregulated Nutrient SensingClearance of Hepatitis C Virus Improves Insulin Resistance During and After Peginterferon and Ribavirin Therapy.26308911
Communicable Diseases, Hepatitis C, ChronicDeregulated Nutrient SensingPatients with chronic hepatitis C virus (HCV) infection are at a greater risk of developing insulin resistance (IR).26308911
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingTo detect the levels of plasma High-Mobility Group Box-1(HMGB1) in Chinese subject with obesity and type 2 diabetes mellitus (T2DM), and to investigate the correlations between plasma HMGB1 concentration and parameters of body fat, insulin resistance (IR) metabolism and inflammation.26317615
Hyperglycemia, Inflammation, Hyperlipidemia, AtherosclerosisDeregulated Nutrient SensingHyperglycemia, insulin resistance, dislipidemia, oxidative stress and inflammation are well-documented risk factors for subclinical atherosclerosis.26318108
Hyperlipidemia, InflammationDeregulated Nutrient SensingThe ORs for insulin resistance, dislipidemia, oxidative stress and inflammation were higher with increasing DPP4 quartiles (P < 0.001 for trend).26318108
Vascular Diseases, Diabetes MellitusDeregulated Nutrient SensingAssociation between CETP gene polymorphism, insulin resistance and risk of diabetes mellitus in patients with vascular disease.26318399
Diabetes MellitusDeregulated Nutrient SensingGenetic inhibition of Cholesteryl Ester Transfer Protein (CETP) might be associated with insulin resistance and incident type 2 diabetes mellitus (T2DM).26318399
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThis study investigated the relation between a genetic variant in the CETP gene and measures of insulin resistance and incident T2DM in patients with manifest cardiovascular disease (CVD).26318399
Vascular DiseasesDeregulated Nutrient SensingPresence of CETP SNP rs3764261 is not associated with insulin resistance and incident T2DM in patients with clinically manifest vascular disease.26318399
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingBACKGROUND Many renal transplant recipients develop complications such as obesity, posttransplantation diabetes mellitus, and dyslipidemia.26319527
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidaemia and low-density lipoprotein cholesterol (LDL-C) target levels were defined according to the Swiss Group for Lipids and Atherosclerosis.26321470
DyslipidemiasDeregulated Nutrient SensingIn Switzerland, the increase over time in dyslipidaemia prevalence was not paralleled by a similar increase in LLM.26321470
HypothyroidismDeregulated Nutrient SensingA significantly higher TG/HDL-C ratio and lower mean insulin sensitivity ratio observed in men with hypothyroidism, indicated higher insulin resistance in men.26323464
FAM126A geneDeregulated Nutrient SensingA novel mutation in SIRT1-AS leading to a decreased risk of HCC.26324025
FAM126A geneDeregulated Nutrient SensingSIRT1-AS overexpression promoted the prolife-ration of the human HCC cell lines by upregulating the SIRT1 protein level.26324025
FAM126A geneDeregulated Nutrient SensingA single-nucleotide mutation (622U>C) in the SIRT1-AS sequence was found when we used gene sequencing as an assistant approach for HCC diagnosis.26324025
FAM126A geneDeregulated Nutrient SensingMoreover, the mean level of SIRT1-AS was much higher in the HCC patients compared to non-hepatopathy volunteers (P<0.01), whereas the opposite effect was observed for the mutant ratio.26324025
FAM126A geneDeregulated Nutrient SensingTaken together, we identified a novel mutation in SIRT1-AS leading to a decreased risk of HCC.26324025
FAM126A geneDeregulated Nutrient SensingThe results of the present study suggest that the 622C mutant of SIRT1 antisense transcript suppresses HCC cell line proliferation, decreases the risk of HCC and is a potential target for gene therapy.26324025
Diastolic dysfunction, DyslipidemiasDeregulated Nutrient SensingEffects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction (Stat-LVDF Study).26328497
Atherosclerosis, Hua Deregulated Nutrient SensingThe long-term effective control of serum uric acid by allopurinol may improve insulin resistance, decrease the serum levels of hs-CRP, reduce the carotid IMT, and may delay the development of atherosclerosis in patients with T2DM and asymptomatic HUA.26328636
DyslipidemiasDeregulated Nutrient SensingOur findings suggest that an increased Hb level is a predictor of elevated serum ALT in adolescent girls with dyslipidaemia.26328752
Periodontitis, Diabetes MellitusDeregulated Nutrient SensingAssociation of periodontitis with insulin resistance, b-cell function, and impaired fasting glucose before onset of diabetes.26329671
PeriodontitisDeregulated Nutrient SensingPeriodontitis and insulin resistance (IR) show bidirectional relationship.26329671
Glucose Intolerance (disease), Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingThis study investigated the clinicopathologic factors associated with the development of glucose intolerance or overt diabetes mellitus (DM) after distal pancreatectomy, and the correlation between resected pancreas volume and endocrine function impairment.26330237
Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingDyslipidemia in HIV Infected Children Receiving Highly Active Antiretroviral Therapy.26334860
Lipodystrophy, Dyslipidemias, HIV InfectionsDeregulated Nutrient SensingAmong the children on highly active antiretroviral therapy (HAART), 38.3 % had dyslipidemia and 80.2 % had lipodystrophy, while 25 % antiretroviral therapy (ART) naive HIV infected children had dyslipidemia.26334860
Lipodystrophy, DyslipidemiasDeregulated Nutrient SensingNo clinically significant risk factors could be identified that increased the risk of dyslipidemia or lipodystrophy in children on highly active antiretroviral therapy (HAART).26334860
Polycystic Ovary SyndromeDeregulated Nutrient SensingThe Mitochondrial tRNALeu(UUR) A3302G Mutation may be Associated With Insulin Resistance in Woman With Polycystic Ovary Syndrome.26335180
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingJoint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.26337056
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a well-established risk factor for cardiovascular disease.26337056
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingLow folate status and homocysteine metabolism gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) may have a synergistic effect increased the incidence of dyslipidemia in Chinese hypertensive population.26337056
HyperglycemiaDeregulated Nutrient SensingThe results demonstrated that hyperglycemia enhanced HNSCC cell malignancy over time through suppression of cell differentiation, promotion of cell motility, increased resistance to cisplatin, and up-regulation of the nutrient-sensing Akt/AMPK-mTORC1 pathway.26337468
Dyslipidemias, Stenosis, Myocardial IschemiaDeregulated Nutrient SensingIn patients without organic stenosis, ACh-positive patients (n = 640) were older, had dyslipidemia, and were more likely to have a family history of ischemic heart disease than nonspasm patients (n = 762).26337988
Vascular DiseasesDeregulated Nutrient SensingGM1 may be an attractive target for the detection, prevention, and therapy of insulin resistance and related vascular diseases, particularly in older people.26338710
Dyslipidemias, USF1 wt AlleleDeregulated Nutrient SensingOur findings indicate that, in well characterized FCHL individuals, variants in LDLR and LPL provide a small contribution to this dyslipidemia, thus limiting the need for such genetic testing.26342331
Nasal PolypsDeregulated Nutrient SensingThus we hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1-induced EMT.26342525
Nasal PolypsDeregulated Nutrient SensingWe sought to determine the role of SIRT1 in patients with nasal polyposis.26342525
CraniosynostosisDeregulated Nutrient SensingImmunohistochemistry, immunoblotting, and immunoprecipitation were done to evaluate SIRT1, EMT, and hypoxic markers in human nasal epithelial cells or sinonasal tissues from the mice and the patients with CRS with or without NPs.26342525
polypsDeregulated Nutrient SensingIn addition, resveratrol (a SIRT1 activator) treatment suppressed nasal polypogenesis in WT mice; however, sirtinol (a SIRT1 inhibitor) administration increased the polyp burden in SIRT1 transgenic mice.26342525
polyps, CraniosynostosisDeregulated Nutrient SensingIn sinonasal specimens from patients with CRS, SIRT1 was downregulated in the mucosa from patients with polyps compared with levels seen in patients without polyps.26342525
Exophytic Polypoid LesionDeregulated Nutrient SensingThe intranasal transfection of a small hairpin SIRT1 lentiviral vector induced more nasal polypoid lesions in SIRT1 transgenic mice.26342525
CraniosynostosisDeregulated Nutrient SensingFinally, mucosal extracts from patients with CRS without NPs increased SIRT1 expression in nasal epithelial cells, whereas those from patients with CRS with NPs did not.26342525
No metabolic abnormalities, Hyperhomocysteinemia, Tyrosine Transaminase Deficiency DiseaseDeregulated Nutrient SensingHowever, multiple studies have implicated metabolic abnormalities such as insulin resistance, hormonal deficiencies, and hyperhomocysteinemia.26343025
DyslipidemiasDeregulated Nutrient SensingIncreased serum soluble corin in dyslipidemia: A cross-sectional study.26344336
DyslipidemiasDeregulated Nutrient SensingAs a physiological activator of natriuretic peptides, corin might also be associated with dyslipidemia.26344336
DyslipidemiasDeregulated Nutrient SensingSerum soluble corin was significantly increased in participants with dyslipidemia in both men (P<0.001) and women (P<0.001).26344336
DyslipidemiasDeregulated Nutrient SensingAfter controlling for the confounding factors, OR of dyslipidemia positively increased with increasing levels of serum soluble corin in men (P for trend=0.011) and women (P for trend=0.043).26344336
DyslipidemiasDeregulated Nutrient SensingOur findings suggested that serum soluble corin may be a marker or risk factor for dyslipidemia.26344336
Sleep Apnea, ObstructiveDeregulated Nutrient SensingEffect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome.26345325
Cardiovascular DiseasesDeregulated Nutrient SensingSIRT1 regulates endothelial nitric oxide (NO) synthase, restores NO availability, and is involved in different aspects of cardiovascular disease.26345325
Sleep Apnea, ObstructiveDeregulated Nutrient SensingWe also investigated whether or not OSAS patients who received nasal continuous positive airway pressure (CPAP) treatment showed improvements in the levels of SIRT1.26345325
Sleep Apnea, ObstructiveDeregulated Nutrient SensingIn the patients with OSAS, the level of SIRT1 in the blood, its activity, and that of NO x was lower than those of normal subjects before nasal CPAP treatment.26345325
Sleep Apnea, ObstructiveDeregulated Nutrient SensingSuccessful treatment for OSAS with nasal CPAP can restore blood levels of the SIRT1 protein and its activity and serum levels of NO x .26345325
physiopathologicalDeregulated Nutrient SensingIn regression analysis that adjusted for body mass index, lower plasma PCSK9 strengthened the association of apoB to WAT dysfunction and insulin resistance.26350813
Fibrosis Assessment, Dyslipidemias, Hepatomegaly, Wolman DiseaseDeregulated Nutrient SensingLAL deficiency (LAL D) presents and progresses as a continuum with dyslipidemia, hepatomegaly, and liver fibrosis.26350820
Dyslipidemias, Liver CirrhosisDeregulated Nutrient SensingTo improve the understanding of the genetic basis of LAL D, an underappreciated cause of dyslipidemia and cirrhosis, we studied DNA samples from patients with various phenotypes of dyslipidemia.26350820
Dyslipidemias, Liver CirrhosisDeregulated Nutrient SensingWe conducted a phase 3 trial of enzyme-replacement therapy in children and adults with lysosomal acid lipase deficiency, an underappreciated cause of cirrhosis and severe dyslipidemia.26352813
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe group with the Cross of Andreas developed more glucose intolerance and diabetes than the group without the sign.26353100
Increased insulin levelDeregulated Nutrient SensingThe FII algorithm may be a useful tool for reducing postprandial hyperinsulinemia in T2DM, thereby potentially improving insulin resistance and b-cell function.26354547
Blood Glucose, AtherosclerosisDeregulated Nutrient SensingDiurnal salivary cortisol, glycemia and insulin resistance: The multi-ethnic study of atherosclerosis.26356041
C5orf38 geneDeregulated Nutrient SensingCompared with 96 controls, patients with LAAS, CEI, and LAC subtypes showed higher levels of white blood cells, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), metalloproteinase 9 (MMP-9), glucose, and iron (p < 0.05); and lower high-density lipoprotein cholesterol (HDL-C) (p < 0.0001); platelets, insulin, insulin resistance, and homocysteine were higher in LAC (p < 0.0001); ferritin was higher in LAAS (p < 0.0001); and total cholesterol (TC) was lower in LAAS and CEI (p < 0.01).26359121
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingWhile the insulin level and insulin resistance rate were higher in reproductive aged PCOS than in healthy women, the difference of these risk factors decreased overtime.26360602
Acromegaly, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingThe growth hormone (GH) excess displayed in acromegaly induces insulin resistance up to diabetes mellitus (DM).26361517
Aneurysm, Dyslipidemias, atherosclerotic, Hypertension, CTCAEDeregulated Nutrient SensingLate aneurysm formation is thought to occur secondary to atherosclerotic degeneration of the SVG with background hypertension and dyslipidaemia accelerating the process.26361745
Coronary Stenosis, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe confirmed that severe coronary stenosis was independently associated with both the relative difference in SBP between arms and baPWV, in addition to age, gender, hypertension, dyslipidemia, diabetes mellitus and ankle-brachial index by a logistic regression analysis.26362246
Glucose Intolerance (disease), ETV3 wt AlleleDeregulated Nutrient SensingPrior to dose adjustment for plasma volume, p value was <0.001 for T1(myo,c) between MetS and non-MetS groups and was 0.13 between subjects with and without glucose intolerance; after adjustment for PV, p value was 0.63 and 0.99.26362875
Presenile dementia, Dyslipidemias, Heart failureDeregulated Nutrient SensingHeart failure (HF) is associated with an increased risk of dementia, and studies show that dyslipidemia may be involved in the pathogenesis of dementia.26363909
Polycystic Ovary Syndrome, Diabetes Mellitus, Non-Insulin-Dependent, diabeticDeregulated Nutrient SensingSurprisingly low infertility rate in married type 2 diabetic women: A rather curious paradox to the current opinion of insulin resistance as the joint pathogenesis of poly cystic ovary syndrome and type 2 diabetes mellitus.26364227
Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Diabetes MellitusDeregulated Nutrient SensingSharing the same pathophysiologic principle which is insulin resistance, type 2 diabetes mellitus (T2DM) and poly cystic ovary syndrome (PCOS) are usually considered closely related and easily interchangeable medical entities.26364227
Prostate Cancer Outcomes StudyDeregulated Nutrient Sensingwe would suggest that, despite the well-established fact of insulin resistance as the common pathophysiologic process for T2DM and PCOS, they are definitely separate medical entities.26364227
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingAs a matter of fact T2DM and PCOS are the two opposite aspect of the insulin resistance coin.26364227
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingFrequently reported baseline medical conditions were hypertension (45.8%/46.7%) and dyslipidemia (36.4%/60.0%).26365276
DyslipidemiasDeregulated Nutrient SensingThe rates of CAD risk factors in young adults are high and the most important risk factors are dyslipidaemia, smoking, and overweight/obesity.26365941
Endometrial CarcinomaDeregulated Nutrient SensingThis study aimed to clarify the expression and role of SIRT1 in endometrial carcinoma.26367491
Endometrial CarcinomaDeregulated Nutrient SensingBecause a high-calorie diet was a well-known risk factor for endometrial carcinoma, we first hypothesized that SIRT1 might be downregulated in normal endometrial glandular cells of obese women.26367491
Endometrial CarcinomaDeregulated Nutrient SensingIn contrast, regardless of BMI, the immunohistochemical expression of SIRT1 was significantly higher in endometrial carcinoma (108 cases) than in normal endometria (60 cases) (P<0.05), and its overexpression was associated with a shorter survival (P<0.05).26367491
Endometrial CarcinomaDeregulated Nutrient SensingOur experiments in vivo revealed that SIRT1 accelerated the proliferation of endometrial carcinoma cell lines (HHUA, HEC151, and HEC1B).26367491
NeoplasmsDeregulated Nutrient SensingIn addition, SIRT1 overexpression in HHUA cells accelerated tumor growth and cisplatin resistance in nude mice, and EX527 significantly suppressed the growth of tumors of HHUA and HEC1B cells.26367491
Aggressive behavior, Endometrial Carcinoma, Malignant NeoplasmsDeregulated Nutrient SensingIn conclusion, SIRT1 is involved in the acquisition of the aggressive behavior associated with endometrial carcinoma, and the SIRT1 inhibitor, EX527, may be a useful agent for the treatment of this malignancy.26367491
Endometrial CarcinomaDeregulated Nutrient SensingSirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.26367491
Carcinoma of lungDeregulated Nutrient SensingRICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors.26370156
Carcinoma of lungDeregulated Nutrient SensingThe mTORC1/2 inhibitors were significantly more active against RICTOR-amplified lung cancer cells as compared with other agents targeting the PI3K-AKT-mTOR pathway.26370156
NeoplasmsDeregulated Nutrient SensingThe index patient has been treated with mTORC1/2 inhibitors that led to tumor stabilization for more than 18 months.26370156
Carcinoma of lungDeregulated Nutrient SensingRICTOR amplification may define a novel and unique molecular subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors.26370156
Eosinophilic disorderDeregulated Nutrient SensingCorticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with eosinophilia.26370863
DyslipidemiasDeregulated Nutrient SensingThese patients were significantly older (73 +- 9 vs 65 +- 16 years; P = 0.010), had more often dyslipidemia (79% vs 42%; P = 0.038), more severe AS (peak velocity: 3.9 +- 0.6 vs 3.5 +- 0.6 m/s; P = 0.002), larger indexed left atrial area (10.2 +- 2.5 vs 8.7 +- 1.9 cm(2)/m(2); P = 0.006), and a higher increase in annualized BNP (+90 +- 155 vs +7 +- 49 pg/mL/y; P = 0.010).26371385
Degenerative disorderDeregulated Nutrient SensingSIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human IVD NP cells, suggesting that rhSIRT1 may be a potent treatment agent for human degenerative IVD disease.26373839
AcneDeregulated Nutrient SensingAssociation between isolated female acne and insulin resistance: a prospective study.26373866
Increased insulin level, Prostate Cancer Outcomes StudyDeregulated Nutrient SensingNowadays hyperinsulinemia and insulin resistance are well-known characteristics of PCOS.26373866
DyslipidemiasDeregulated Nutrient SensingStudy patients had persistent dyslipidemia despite receiving high-dose statin treatment.26374297
Stomach Carcinoma, Atrial Fibrillation by ECG Finding, Dyslipidemias, Ischemic stroke, Hypertension, CTCAEDeregulated Nutrient SensingIndependent risk factors of ischemic stroke in gastric cancer patients included age, hypertension, atrial fibrillation, dyslipidemia, and having received major surgery for gastric cancer.26376378
Glucose Intolerance (disease), DyslipidemiasDeregulated Nutrient SensingLogistic regression analysis revealed increase of the odds ratios of the WC for glucose intolerance (p<0.001), high blood pressure (p<0.001) and dyslipidemia (p<0.01) in men.26376586
Glucose Intolerance (disease), DyslipidemiasDeregulated Nutrient SensingIn women, the odds ratios of the WC for glucose intolerance (p<0.01) and dyslipidemia (p<0.001) were significantly increased, and odds ratio of the VAT thickness for high blood pressure (p<0.01) was significantly increased.26376586
DyslipidemiasDeregulated Nutrient SensingIn contrast, the odds ratio of the VAT thickness was significantly increased only for dyslipidemia (p<0.01) in men.26376586
NeoplasmsDeregulated Nutrient SensingRestriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model.26378060
NeoplasmsDeregulated Nutrient SensingWe found that both PR and IF inhibit tumor growth and mTORC1 phosphorylation in tumor xenografts.26378060
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingOur work represents the first finding that PR may reduce mTORC1 activity in tumors and multiple somatic tissues, and suggest that PR may represent a highly translatable option for the treatment not only of cancer, but also other age-related diseases.26378060
ObesityDeregulated Nutrient SensingWhereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive.26378474
DyslipidemiasDeregulated Nutrient SensingThis suggests that national strategies in public health be developed to improve the treatments to low-income rural minorities with dyslipidemia.26378561
DyslipidemiasDeregulated Nutrient SensingObese children have increased cardiometabolic risk, including dyslipidemia, insulin resistance and elevated blood pressure.26378769
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHigher selenium level has been hypothesized to have the potential to reduce the risk of cardiovascular diseases including dyslipidemia.26380972
DyslipidemiasDeregulated Nutrient SensingOur results suggest long-term selenium exposure level may be associated with the risk of dyslipidemia in elderly population.26380972
Neurogenic InflammationDeregulated Nutrient SensingLocal angiotensin II (AII) and sirtuin 1 (SIRT1) play a major role in the modulation of neuroinflammation, oxidative stress and aging-related dopaminergic vulnerability to damage.26384348
Nerve DegenerationDeregulated Nutrient SensingReciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration.26384348
Sleep-Disordered Breathing, Diabetes MellitusDeregulated Nutrient SensingEasily collected symptoms of SDB are strongly associated with insulin resistance and the incidence of type 2 diabetes in older adults.26384390
Heart Diseases, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe VRFs most frequently recognized by patients as their own were stress, hypertension, dyslipidemia, cigarette smoking, and cardiac disease.26387042
Prostate Cancer Outcomes Study, ObesityDeregulated Nutrient SensingThis may be because obesity and insulin resistance are integral parts of PCOS and are the mechanisms through which PCOS exerts metabolic effects.26387977
Adipose tissue loss, Steatohepatitis, Hypertriglyceridemia, Acquired generalized lipodystrophy, LEPTIN DEFICIENCY OR DYSFUNCTIONDeregulated Nutrient SensingAcquired generalized lipodystrophy (AGL) is associated with leptin deficiency as a result of adipose tissue loss and hypertriglyceridemia, insulin resistance, and hepatic steatosis.26390101
Autoimmune Diseases, HypertriglyceridemiaDeregulated Nutrient SensingMetreleptin therapy is of considerable clinical benefit to reduce insulin resistance and hypertriglyceridemia and did not appear to alter the clinical course of autoimmune disease nor clinical efficacy of immunosuppressive treatments.26390101
ObesityDeregulated Nutrient SensingObesity leads to insulin resistance which subsequently leads to low urinary pH.26393903
Nonalcoholic Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and lipotoxicity are pathognomonic in non-alcoholic steatohepatitis (NASH).26394161
physiopathological, Toxic effect, Fatty Liver DiseaseDeregulated Nutrient SensingLiraglutide reduces metabolic dysfunction, insulin resistance and lipotoxicity in the key metabolic organs in the pathogenesis of NASH.26394161
DyslipidemiasDeregulated Nutrient SensingIn addition, for males, dyslipidemia and prior Ml were moderately strong risk factors.26394490
Skeletal muscle structureDeregulated Nutrient SensingAdipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance.26395744
ObesityDeregulated Nutrient SensingRecent reports indicate that inter/intramuscular adipose tissue (IMAT), composed by adipocytes underneath the deep fascia of the muscles, is positively correlated with aging, obesity and insulin resistance in humans.26395744
Steatohepatitis, ObesityDeregulated Nutrient SensingThe combination of metabolic control, visceral obesity, and insulin resistance may reasonably predict the degree of liver steatosis in T2DM.26398456
Dyslipidemias, Retinal Diseases, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingMultivariate models showed that in men, HbA1c>=7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.26399764
Kidney Failure, ChronicDeregulated Nutrient SensingThe effect of two different high-flux dialysis membranes on insulin resistance in non-diabetic end-stage renal disease patients.26399977
Electronic Source Report FormDeregulated Nutrient SensingCompared to the PS membrane, PPP high-flux membrane decreased insulin resistance by increasing insulin sensitivity among non-diabetic ESRF patients.26399977
Data types - AddressDeregulated Nutrient SensingA therapeutic strategy that enhances brain insulin/Igf1 signaling activity to a more robust ApoE2-like phenotype favoring both energy production and amyloid homeostasis holds promise for AD prevention and early intervention.26402005
Alzheimers Disease", Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin-like growth factor (IGF)-1, through insulin/IGF-1 signaling pathway, is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and Alzheimer's disease.26402757
Inflammation, Glucose Intolerance (disease), Obesity, HyperlipidemiaDeregulated Nutrient SensingEpidemiological evidence indicates an inverse association between nut consumption and obesity, inflammation, hyperlipidaemia and glucose intolerance.26404365
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most common comorbidities were hypertension (61.3%), diabetes (9.1%), and dyslipidemia (6.9%), and 10.7% were smokers.26407512
DyslipidemiasDeregulated Nutrient SensingSpecific measures against smoking and sedentary lifestyle, avoidance of advanced stages of immunosuppression, and appropriate treatment of dyslipidemia and dysglicemia are urgently needed to cope with the disease in Brazil.26409740
Chronic Obstructive Airway Disease, Hypertension, CTCAE, Kidney Failure, DyslipidemiasDeregulated Nutrient SensingWomen were older and had a greater incidence of hypertension, smoking, chronic obstructive pulmonary disease, dyslipidemia, and renal insufficiency.26409846
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHypertension was present in 60.5%, diabetes in 22.5% of patients, 46.5% had dyslipidemia, 18.6% were current smokers, and 45.7% had a family history of cardiovascular disease.26412411
Restenosis, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus is an independent risk factor for restenosis, so reducing insulin resistance is being studied as a new treatment approach.26413014
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingPatients were assigned to four groups, AMI without dyslipidemia or DM, with dyslipidemia, with DM and with both dyslipidemia and DM.26415345
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingThe plasma MDA level was significantly higher (p < 0.001) in patients with both dyslipidemia and DM or with only DM in comparison to patients without dyslipidemia and DM.26415345
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus.26415345
DyslipidemiasDeregulated Nutrient SensingThe increase in AMI incidence in males in the coastal area was associated with an increasing prevalence of dyslipidemia.26416407
DyslipidemiasDeregulated Nutrient SensingThere were no longer any regional differences observed in AMI incidence, which was considered to be associated with increased dyslipidemia especially in the coastal area.26416407
ObesityDeregulated Nutrient SensingVitamin D and related genetic variants are associated with obesity and insulin resistance.26416604
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingMendelian randomization analyses indicate causal roles in PCOS aetiology for higher BMI (P=2.5 x 10(-9)), higher insulin resistance (P=6 x 10(-4)) and lower serum sex hormone binding globulin concentrations (P=5 x 10(-4)).26416764
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo explore the effect of full-mouth disinfection (FMD) on glycemic control and insulin resistance in type 2 diabetes mellitus (DM).26417619
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWithin the limitations of the present study it can be concluded that FMD contributes to significant reduction in insulin resistance, thereby improving the glycemic control in type 2 diabetes mellitus patients.26417619
Hypertension, CTCAE, Dyslipidemias, HaitiDeregulated Nutrient SensingAccording to the current medication and past history, 605 subjects had hypertension (HT), 316 had dyslipidemia (DL), and 182 had type 2 DM.26420191
Diabetes MellitusDeregulated Nutrient SensingProtein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts.26420861
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is a precursor of type 2 diabetes (T2D), and improved risk prediction and understanding of the pathogenesis are needed.26420861
Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingComparison between indexes of insulin resistance for risk prediction of cardiovascular diseases or development of diabetes.26421364
Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThe predictive effect of various insulin resistance indexes for risk of cardiovascular diseases (CVD) or type 2 diabetes (T2DM) is still unclear.26421364
Diabetes MellitusDeregulated Nutrient SensingThe Role of Haemoglobin A1c in Screening Obese Children and Adolescents for Glucose Intolerance and Type 2 Diabetes.26421782
Dyslipidemias, Osage languageDeregulated Nutrient SensingWe demonstrated that patients with OSA had a higher percentage of dyslipidemia than subjects without OSA.26424733
Dementia, Vascular, Diabetes Mellitus, Non-Insulin-Dependent, physiopathologicalDeregulated Nutrient SensingType 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction.26427105
DamageDeregulated Nutrient SensingGender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD-DIABETES study.26427534
Dyslipidemias, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingMetabolic Dyslipidemia and Risk of Coronary Heart Disease in 28,318 Adults With Diabetes Mellitus and Low-Density Lipoprotein Cholesterol <100 mg/dl.26428026
Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe risk of future coronary heart disease (CHD) in subjects with diabetes and "metabolic dyslipidemia" (high triglyceride [TGs] and low high-density cholesterol levels) remains a matter of concern.26428026
Dyslipidemias, Diabetes Mellitus, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingEven in subjects with an LDL-C <100 mg/dl, presence of metabolic dyslipidemia in adults with diabetes is associated with an increased risk of CHD.26428026
Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, effective CHD prevention strategies are needed for adults with diabetes and metabolic dyslipidemia.26428026
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociations of pancreatic b-cell function and insulin resistance with microalbuminuria in type 2 diabetes.26428073
Microalbuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe investigate the relationships of pancreatic b-cell function and insulin resistance with microalbuminuria in a cross-sectional study of patients with type 2 diabetes.26428073
MicroalbuminuriaDeregulated Nutrient SensingThe study suggests insulin resistance is associated with an increased prevalence of microalbuminuria, while improved pancreatic b-cell function is linked to decreased rates of microalbuminuria for those patients.26428073
Tumor necrosisDeregulated Nutrient SensingFasting blood sugar (FBS), insulin, insulin resistance, tumor necrosis factor alpha (TNF-a), and interleukin 6 (IL-6) were measured at baseline and at the end of the study.26430826
FBXO8 geneDeregulated Nutrient SensingMeans of FBS, insulin, insulin resistance, and IL-6 were significantly different between groups after intervention (p < 0.05), whereas TNF-a was not significantly modified (p > 0.05).26430826
Inflammation, Chronic Kidney Diseases, Metabolic Syndrome XDeregulated Nutrient SensingChronic Kidney Disease in Non-Diabetic Older Adults: Associated Roles of the Metabolic Syndrome, Inflammation, and Insulin Resistance.26431218
Partial Wave Spectroscopic Microscopy, Osage language, Dyslipidemias, Diabetes Mellitus, Sleep Apnea, Obstructive, Hypertension, CTCAEDeregulated Nutrient SensingAll PWS patients had obstructive sleep apnea (OSA), 62% had dyslipidemia, 43% had hypertension, and 29% had diabetes mellitus.26431633
Steatohepatitis, Obesity, AbdominalDeregulated Nutrient SensingAndroid fat distribution (abdominal obesity) is associated with insulin resistance, hepatic steatosis, and greater secretion of large very low-density lipoprotein (VLDL) particles in men.26432801
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe following factors were analyzed: sex, age, surgical access (laparotomy vs. laparoscopy), preoperative BMI, waist circumference (WC), type 2 diabetes mellitus (T2DM), high blood pressure, and dyslipidemia.26433591
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingData were adjusted for gender, age, JAK2 mutational status, smoking, dyslipidemia, or hypercholesterolemia requiring drug therapy, antiplatelet therapy, treatment with acetylsalicylic acid, high-sensitive C-reactive protein levels, and absolute monocyte count.26437571
Rabson-Mendenhall SyndromeDeregulated Nutrient SensingAll these features were compatible with Rabson-Mendenhall syndrome, a rare disorder of severe insulin resistance linked to mutations of insulin receptor.26438710
Liver diseasesDeregulated Nutrient SensingPrevious studies revealed that the common sequence variant I148M in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with liver fat content and liver diseases, but not with insulin resistance.26439088
Diabetic careDeregulated Nutrient SensingThe AUCs of plasma insulin levels or insulin resistance index (IRI): (AUCs of insulin) x (AUCs of glucose) as the insulin resistance marker were greater in diabetic CAD group than non-diabetic CAD group (insulin, P = 0.0373; IRI, P = 0.0228).26439243
TG geneDeregulated Nutrient SensingThe AUCs of serum TG or RLP-C levels showed a correlation with the AUCs of plasma insulin (AUC-TG, r = 0.5437, P < 0.0001; AUC-RLP-C, r = 0.6847, P < 0.0001), and they correlated well with the insulin resistance index (AUC-TG, r = 0.7724, P < 0.0001; AUC-RLP-C, r = 0.7645, P < 0.0001).26439243
Postprandial hyperlactemiaDeregulated Nutrient SensingWe found that the insulin resistance showed a close relationship with postprandial hyperlipidemia in CAD patients.26439243
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingAnimal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists.26439389
ObesityDeregulated Nutrient SensingIncreased branched-chain amino acid (BCAA), aromatic amino acid (AAA) and orosomucoid were associated with liver fat accumulation already in its early stage, independent of sex, obesity or insulin resistance (p<0.05 for all).26439744
Prostate carcinomaDeregulated Nutrient SensingMicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence.26439987
Alzheimers DiseaseDeregulated Nutrient SensingChronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer's Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model.26444766
HypoxiaDeregulated Nutrient SensingFurthermore, we found that chronic hypoxia activated AMPK and further inhibited the mTOR signaling pathway, while inhibition of AMPK attenuated autophagy induction through the enhancement of mTOR phosphorylation.26444766
OverweightDeregulated Nutrient SensingThe Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance is Largely Attributable to Central Adiposity in Overweight and Obese Adults.26446485
OverweightDeregulated Nutrient SensingCentral adiposity drives the association between plasma 25(OH)D and insulin resistance in overweight and obese adults.26446485
Degenerative polyarthritis, Osteoporosis, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingMost frequent medical problems were depression/anxiety (37%), osteoporosis/osteopenia (26%), hypertension (21%), dyslipidemia (21%), and osteoarthritis (21%).26446538
Inflammation, Metabolic Syndrome XDeregulated Nutrient SensingWe are first to observe a selective increase in monocyte p38 mitogen-activated protein kinase activity in metabolic syndrome and suggest it as a pivotal molecular target for ameliorating insulin resistance and inflammation.26449239
Inflammation, Diabetes MellitusDeregulated Nutrient SensingAdipose tissue inflammation contributes to the development of complications, such as insulin resistance and type 2 diabetes mellitus.26449750
Hypertension, CTCAE, Disorder of circulatory system, Diabetes MellitusDeregulated Nutrient SensingRecent evidence indicates that resistin may actively participate in the pathophysiology of insulin resistance, diabetes mellitus, hypertension and other circulatory disorders.26450098
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors.26451383
TG gene, DyslipidemiasDeregulated Nutrient SensingIn patients with dyslipidemia, elevated triglyceride (TG) levels, or TG-rich lipoproteins, and cardiovascular risk may remain despite statin therapy.26453247
Dyslipidemias, Alcohol abuse, Obesity, Diabetes MellitusDeregulated Nutrient SensingPatient data, including demographic measures, diagnoses of obesity, diabetes mellitus, dyslipidemia, alcohol abuse, and nicotine dependence were examined.26455587
Dyslipidemias, Blood GlucoseDeregulated Nutrient SensingAppropriate management of glycemia, blood pressure and dyslipidemia in this population is a major public health concern.26455830
CirrhoticDeregulated Nutrient SensingMoreover, insulin resistance was observed in 82.5% of the cirrhotic patients.26457026
Liver CirrhosisDeregulated Nutrient SensingThis increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance.26457026
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe MTTP 297 H polymorphism interacted with age, insulin resistance and BMI to decrease serum apoB containing lipoproteins (LDL-C and non-HDL-C) but increase the risk of NAFLD formation.26458397
Hypertension, CTCAE, Myopathy, FatigueDeregulated Nutrient SensingMifepristone treatment provided rapid improvement in glycemic control, insulin resistance, and hypertension as well as significant diminishment of her myopathy and fatigue.26459648
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe prevalence of dyslipidemia, overweight and obesity were 70 %, 33 % and 8 %, respectively.26466584
Demographics Domain, Dyslipidemias, Diabetes Mellitus, Haiti, Hypertension, CTCAEDeregulated Nutrient SensingMany osteoporotics have comorbid diabetes mellitus (DM), hypertension (HT), and dyslipidemia (DL).26466937
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn case of insulin resistance, which is typical for type 2 diabetes mellitus (T2DM), proteolysis is increased and protein synthesis is decreased; therefore, we can observe changes in the levels of amino acids in diabetics vs. non-diabetics.26467133
B-Lymphocytes, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingType-2 Diabetes (T2D) is characterized principally by insulin resistance in target tissues followed by decreased insulin production due to b-cell failure.26469782
Cessation of life, Dyslipidemias, Demographics Domain, Chronic Kidney DiseasesDeregulated Nutrient SensingCompared with non-obese DM patients (62% of AMI patients), obese DM patients had: higher incidence of dyslipidemia (31 vs. 24%, P < 0.01); lower incidence of chronic kidney disease (26 vs. 33%) (P < 0.01); higher left ventricular ejection fraction after AMI (53 +- 11 vs. 50 +- 12%, P < 0.001); and lower 2-year cardiac and all-cause death occurrence (0.7 vs. 3.6% and 1.9 vs. 5.2%, both P < 0.01) and cumulative incidence in Kaplan-Meier analysis (P < 0.005, respectively).26471283
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPhysical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia.26474157
Demographics Domain, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Hypertension, CTCAEDeregulated Nutrient SensingPresence of diabetes mellitus (DM), arterial hypertension (AH), dyslipidemia, body mass index > 25 kg/m(2), and daily glucose load > 100 g were associated with NAFLD occurrence.26475841
Dysmorphic facies, Dyslipidemias, Anemia, Vitamin B 12 DeficiencyDeregulated Nutrient SensingThe disorders included dysmorphic anomalies, weight and height deviations, raised thyroid hormone levels, dyslipidaemia, anaemia and vitamin D and B12 deficiency.26479250
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia plays a significant role in the progression of cardiovascular disease.26481445
Diabetes MellitusDeregulated Nutrient SensingEradication of HCV has led to improvements in insulin resistance but to date has not been shown to induce remission of diabetes.26482468
Glucose Intolerance (disease)Deregulated Nutrient SensingThere was a significant increase in the prevalence of glucose intolerance by aging in permanent workers.26482960
Microvascular AnginaDeregulated Nutrient SensingIn Cox proportional hazard models both higher SHBG (Hazard Ratio (HR) 1.012 (95% CI 1.002-1.022), P=0.02) and lower calculated free testosterone (cFT) (HR 0.995 (95% CI 0.993-0.998), P=0.001) were risk factors for all cause mortality independently of age, BMI, presence of macro- and microvascular disease, duration of T2DM, hemoglobin, renal function, insulin use, C-reactive protein and homeostatic model of insulin resistance.26483395
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingPatients with diabetes mellitus and cardiovascular disease may not achieve adequate low-density lipoprotein cholesterol (LDL-C) lowering on statin monotherapy, attributed partly to atherogenic dyslipidemia.26486166
Dyslipidemias, diabeticDeregulated Nutrient SensingIn diabetic patients with dyslipidemia, switching from statins to combination ES10/20 therapy generally improved lipoprotein subclass profile and Lp-PLA2 activity more than did statin dose-doubling and was comparable with R10, consistent with its lipid effects.26486166
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingInsulin resistance plays a crucial role in the etiology of polycystic ovary syndrome (PCOS).26486309
Obesity, Abdominal, Prostate Cancer Outcomes Study, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, metabolic disturbanceDeregulated Nutrient SensingPCOS is associated with metabolic disturbances such as abdominal obesity, dyslipidemia and type 2 diabetes.26486309
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes and insulin resistance have been associated with shortened telomere length.26486356
ObesityDeregulated Nutrient SensingMaternal obesity and having telomere shortening were associated with insulin resistance in adult offspring.26486356
Dyslipidemias, ETV3 wt AlleleDeregulated Nutrient SensingStatin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia.26486974
Dyslipidemias, Dry Eye Syndromes, Degenerative polyarthritis, Rheumatoid Arthritis, Thyroid Diseases, Kidney FailureDeregulated Nutrient SensingWith regard to systemic comorbidities, dyslipidemia (AOR: 1.63), degenerative arthritis (AOR: 1.56), rheumatoid arthritis (AOR: 1.44), thyroid disease (AOR: 1.79), and renal failure (AOR: 2.56) were associated with a significantly higher prevalence of dry eye syndrome.26488632
Glucose Intolerance (disease), Dyslipidemias, Neoplasms, Cardiovascular DiseasesDeregulated Nutrient SensingComplications were comparable between patients with functioning and non-functioning tumors, including the frequencies of glucose intolerance, cardiovascular disease, and dyslipidemia.26490049
Inflammation, ObesityDeregulated Nutrient SensingWomen of Mexican descent are disproportionally affected by obesity, systemic inflammation, and insulin resistance (IR).26491126
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingInsulin resistance is a characteristic of PCOS patients and is more pronounced in obese patients.26491824
Increased insulin level, Acne, Disorder of male reproductive system, Hirsutism, HyperandrogenismDeregulated Nutrient SensingInsulin resistance and consequent hyperinsulinemia are related to many aspects of the syndrome such as hyperandrogenism, reproductive disorders, acne and hirsutism.26491824
Hyperglycemia, PostprandialDeregulated Nutrient SensingLow-dose prednisolone causes insulin resistance that typically manifests as postprandial hyperglycaemia.26493042
Rheumatoid ArthritisDeregulated Nutrient SensingPrednisolone-induced insulin resistance is not associated with postprandial vascular dysfunction in patients with rheumatoid arthritis.26493042
Cognition, Data types - AddressDeregulated Nutrient SensingCognitive and affective functions, insulin resistance, vascular endothelial function and white matter changes between AD-MetS and AD controls were compared.26493280
Dyslipidemias, Myocardial Ischemia, Hepatobiliary Disorder, Heart failure, Cerebrovascular Disorders, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingTB patients with heart failure, ischemic heart disease, cerebral vascular disease, hypertension, dyslipidemia, chronic kidney disease, and liver disease were more likely to associate with DM (ORs=1.27, 1.23, 1.30, 2.32, 3.26, 1.6, and 1.68, respectively) compared to those without the variables.26494183
InflammationDeregulated Nutrient SensingResistin is an adipocytokine associated with inflammation and insulin resistance.26494484
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingMetformin (MF) acts as a tumour-suppressor in renal cell carcinoma (RCC) by inhibiting the AKT/mTOR pathway via AMPK activation.26496641
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingIt is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disease (NAFLD) patients and whether this association is mediated through traditional risk factors.26496770
diabeticDeregulated Nutrient SensingC18:3n6 and/or D6D (C18:3n6/C18:2n6) were positively associated with insulin resistance and diabetic parameters.26497880
OsteoporosisDeregulated Nutrient SensingDenosumab Inhibition of RANKL and Insulin Resistance in Postmenopausal Women with Osteoporosis.26498169
glucose metabolismDeregulated Nutrient SensingThe aim of our study was to investigate glucometabolic parameters, insulin resistance, and lipid profile in non-diabetic women receiving denosumab.26498169
Osteoporotic FracturesDeregulated Nutrient SensingIn osteoporotic otherwise healthy postmenopausal women, denosumab was not associated with relevant modification of insulin resistance and lipid profile.26498169
Gout, Diabetes Mellitus, Chronic heart failure, Alcohol abuse, Malignant Neoplasms, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingA diagnosis of gout was identified during 2013-2014, with information of diabetes mellitus and insulin resistance, hypertension, chronic heart failure, chronic kidney disease, alcohol abuse, and malignancies.26500085
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHypertension, obesity and no exercise, dyslipidemia and high HbA1c in women, and excessive cigarette/alcohol consumption, increased weight, dyslipidemia and high HbA1c in men were crucial.26503421
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingThey also had a higher prevalence of hypertension (34% versus 25%; p < 0.001), dyslipidemia (79% versus 74%; p < 0.001), and obesity (29% versus 16%; p < 0.001) and a higher Framingham risk score (8% versus 6%; p < 0.001).26504260
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingCohort of 99 400 patients with diabetes, hypertension, or dyslipidemia in 2007 without a history of cardiovascular disease.26505061
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance has been associated with cardiovascular disease in peritoneal dialysis patients.26507143
ObesityDeregulated Nutrient SensingThe aim of this study was to test whether insulin resistance is associated with obesity parameters, peritoneal transport rate, and glucose absorption.26507143
PTPRF geneDeregulated Nutrient SensingA total of 18 patients (35.3%) who had insulin resistance presented with higher LAR and rel.FM (7.3 [12.3, interquartile range] versus 0.7 [1.4, interquartile range], P<0.001, and 39.4 +- 10.1% versus 27.2 +- 11.5%, P=0.002, respectively), lower IGFBP-1 (8.2 +- 7.2 versus 21.0 +- 16.3 ng/ml, P=0.002), but similar glucose absorption and small-solute transport compared with patients without insulin resistance.26507143
PTPRF gene, ObesityDeregulated Nutrient SensingInsulin resistance in nondiabetic peritoneal dialysis patients is associated with obesity and LAR independent of glucose absorption and small-solute transport status.26507143
ObesityDeregulated Nutrient SensingFast transport status was not associated with higher likelihood of obesity or insulin resistance.26507143
TG geneDeregulated Nutrient SensingTG and UG are therefore novel potential modulators of insulin resistance and may contribute to predict its time-related changes in humans.26508327
Metabolic acidosis, Chronic Kidney DiseasesDeregulated Nutrient SensingIn chronic kidney disease (CKD), dietary acid may promote metabolic acidosis and insulin resistance, which in turn may contribute to adverse clinical health outcomes.26508542
Glucose Intolerance (disease), Fibrosis AssessmentDeregulated Nutrient SensingGlucose intolerance in cystic fibrosis as a determinant of pulmonary function and clinical status.26508676
Hypothyroidism, Hypertension, CTCAE, Kidney Diseases, ObesityDeregulated Nutrient SensingUntreated or sub-clinical hypothyroidism is associated with insulin resistance, obesity, adverse effects on cardiovascular system, hypertension and in turn risk of nephropathy.26511212
Dyslipidemias, Albuminuria, Chronic Kidney DiseasesDeregulated Nutrient SensingDespite high frequencies of albuminuria (74.8%) and dyslipidaemia (93.0%) among CKD patients, only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins.26511783
Dyslipidemias, Demographics Domain, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of dyslipidemia was 51.2 % in patients versus 12.1 % in controls (p < 0.001), type 2 diabetes mellitus (DM) was 7.3 versus 17 % (p = 0.292), hypertension was 44 versus 22 % (p = 0.060), and MS was 17 versus 14.6 % (p = 0.957).26511949
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingIn patients, an association was found between the presence of hypovitaminosis D and the prevalence of dyslipidemia, hypertension and MS and between zIGF-I and the prevalence of hypertension.26511949
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingHypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension.26511949
Dyslipidemias, Hypertension, CTCAE, Somatotropin deficiencyDeregulated Nutrient SensingThe presence of hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension in GHD patients, suggesting the involvement of both factors in the CV risk in these patients.26511949
Dyslipidemias, Endothelial dysfunction, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia, proinflammatory cytokines, endothelial dysfunction signs, and RhoA/Rho-kinase (ROCK) activation are considered risk factors of cardiovascular diseases.26512756
DyslipidemiasDeregulated Nutrient SensingThe overall prevalence of dyslipidemia in patients was 77.5%.26514630
Dyslipidemias, Meibomian gland dysfunctionDeregulated Nutrient SensingDyslipidemia and its association with meibomian gland dysfunction.26515235
Dual-affinity B7-H3/CD3-targeted Protein MGD009, Dyslipidemias, Meibomian gland dysfunctionDeregulated Nutrient SensingThe primary purpose of this study was to determine if there is an association between dyslipidemia and meibomian gland dysfunction (MGD).26515235
Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingEye care providers may have a role in discovering undiagnosed dyslipidemia, an important risk factor for cardiovascular illness.26515235
DyslipidemiasDeregulated Nutrient SensingPrevalence and Risk Factors Associated with Dyslipidemia in Chongqing, China.26516874
DyslipidemiasDeregulated Nutrient SensingThe increasing prevalence of dyslipidemia has become a worldwide public health problem, and the prevalence varies widely according to socioeconomic, cultural and ethnic characteristics.26516874
Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias, HyperlipidemiaDeregulated Nutrient SensingAmong the 2009 patients with dyslipidemia, 44.2% had isolated hypertriglyceridemia, 14.7% had isolated hypercholesterolemia, 13.2% had mixed hyperlipidemia, and 28.0% had isolated low high-density lipoprotein cholesterol.26516874
Dyslipidemias, ObesityDeregulated Nutrient SensingMultivariable logistic regression analysis revealed that dyslipidemia was associated with age, education level, physical activity, obesity and central obesity for both men and women.26516874
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingIn conclusion, the results indicated dyslipidemia, particularly hypertriglyceridemia and low high-density lipoprotein cholesterol, are very common in Chongqing.26516874
Hypertension, CTCAEDeregulated Nutrient SensingHazard ratios (HR) for insulin resistance, LDL-c, age, sex, and the presence of hypertension were determined in a multivariate analysis.26517432
ImpairedDeregulated Nutrient SensingActivation of AMP-activated protein kinase (AMPK) suppressed mammalian target of rapamycin (mTOR) pathway, resulting in impaired cancer cell proliferation.26520441
Stomach CarcinomaDeregulated Nutrient Sensingp-AMPK and p-ACC were frequently inactivated in both cohorts of gastric cancer samples, while p-mTOR, p-S6, and p-4EBP1 were frequently activated in the small cohort of gastric cancer.26520441
EndotoxemiaDeregulated Nutrient SensingDeacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia.26522327
SepsisDeregulated Nutrient SensingSIRT1 directly interacted with HMGB1 via its N-terminal lysine residues (28-30), and thereby inhibited HMGB1 release to improve survival in an experimental model of sepsis.26522327
Tumor necrosisDeregulated Nutrient SensingBy contrast, inflammatory stimuli such as lipopolysaccharide (LPS) and tumor necrosis factor-a promoted HMGB1 release by provoking its dissociation from SIRT1 dependent on acetylation, thereby increasing the association between HMGB1 and chromosome region maintenance 1, leading to HMGB1 translocation.26522327
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingMicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background.26523671
Prostatic DiseasesDeregulated Nutrient SensingComplex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease.26526283
Rheumatoid ArthritisDeregulated Nutrient SensingInsulin resistance and levels of adipokines in patients with untreated early rheumatoid arthritis.26526677
Urinary IncontinenceDeregulated Nutrient SensingTo investigate the association between insulin resistance (IR) and urinary incontinence in Korean adult women by analyzing the data from the Korea National Health and Nutrition Examination Survey IV (KNHANES) 2007-2009.26529410
Hyperinsulinism, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingInsulin resistance (IR) and hyperinsulinaemia are both related to an increased cardiovascular risk, but whether IR predicts coronary heart disease (CHD) independently of other risk factors in patients with type 2 diabetes (T2D) is a topic of considerable controversy.26531321
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingWe confirmed an increased risk in subjects with dyslipidemia (high density lipoprotein <59 mg/dL: 17.8% of controls, 43.2% of patients, P = 0.0002; low density lipoprotein >130 mg/dL: 26.7% controls, 54.1% patients, P = 0.0002), arterial hypertension (60% controls, 75.7% patients, P = 0.023), and high body mass index (28.9% controls, 70.3% patients, P < 0.0001, and excluded involvement of the selected polymorphisms in RVO.26535647
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe average age was 64 years (60-71), mean BMI of 49.6 kg/m2 (38-66), mean follow-up of 5.9 years; 91% of patients were hypertensive, 56% diabetics and 39% had dyslipidemia.26537266
Gastro-esophageal reflux disease with esophagitis, Dyslipidemias, Diabetes Mellitus, Sleep Apnea, CTCAE, Hypertension, CTCAEDeregulated Nutrient SensingComorbidities observed were hypertension (19%), type 2 diabetes mellitus (6.6%), dyslipidemia (7.5%), sleep apnea (16.6%), reflux esophagitis (10%) and orthopedic diseases (7.5%).26537277
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRemission of diabetes and dyslipidemia occurred in all patients.26537277
Dyslipidemias, diabeticDeregulated Nutrient SensingOf the total 1,975 diabetic patients, only 377 (19.1%) were receiving drugs for dyslipidemia.26539005
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe percentage of the adolescents and young adults with diabetes mellitus, hypertension, and dyslipidemia were diminished gradually at 6 months postoperatively (P < .001).26539837
Eating Disorders, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingRe-establishing menstruation is an important goal in the treatment of eating disorders, to avoid dyslipidaemia and the risk of future cardiovascular disease.26540134
Dyslipidemias, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingSubjects in the 3(rd) tertile of Hcy levels had an accelerated rate of eGFR decline and an increased risk of incident CKD, as compared with those in the 1st tertile, after adjusting for age, gender, baseline diabetes, SBP, BMI, smoking, dyslipidemia, eGFR, folate and vitamin B12 levels.26553372
ObesityDeregulated Nutrient SensingAdiponectin level was inversely correlated with age (r = -0.015), parameters of both obesity (R = 0.437;p < 0.001) and insulin resistance (R = 0.374; p < 0.01).26554109
PsoriasisDeregulated Nutrient SensingA Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis.26556603
Inflammatory disorderDeregulated Nutrient SensingActivation of Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, is an unexplored therapeutic approach for treatment of inflammatory diseases.26556603
PsoriasisDeregulated Nutrient SensingWe randomized 40 patients with moderate-to-severe psoriasis (4:1) to three escalating doses of SRT2104, a selective activator of SIRT1, or placebo.26556603
PsoriasisDeregulated Nutrient SensingGiven the interesting signals of clinical activity, impact on gene expression and the generally favorable safety profile seen in this study, further investigation of SIRT1 activators for the treatment of psoriasis is warranted.26556603
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingExcessive cholesterol intake could cause dyslipidemia, which is a major risk factor of coronary artery disease (CAD).26556629
Hyperglycemia, Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resistance and systemic inflammation.26567860
Non-alcoholic Fatty Liver Disease, physiopathologicalDeregulated Nutrient SensingSerum leptin seems to have an association with NAFLD both in male and female prediabetic subjects and this association in turn, is mediated by insulin secretory dysfunction and insulin resistance among these subjects.26569494
HyperuricemiaDeregulated Nutrient SensingLowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia.26571421
Diabetes Mellitus, Non-Insulin-Dependent, HyperuricemiaDeregulated Nutrient SensingHyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial.26571421
HyperuricemiaDeregulated Nutrient SensingHere we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.26571421
Inflammation, HyperuricemiaDeregulated Nutrient SensingAllopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia.26571421
Papillary thyroid carcinoma, Percutaneous transhepatic cholangiographyDeregulated Nutrient SensingSeveral reports have shown that insulin resistance is associated with papillary thyroid carcinoma (PTC).26573560
Hypertension, CTCAEDeregulated Nutrient SensingThese findings suggest that insulin resistance has a synergistic effect on the obesity-hypertension association in young adults, indicating that the role of adiposity in the development of hypertension is modified by insulin resistance.26573703
Hypertensive (finding), Prediabetes syndrome, DyslipidemiasDeregulated Nutrient SensingHypertensive systolic blood pressure values (p = 0.012), prediabetes (p < 0.001), fatty liver (p < 0.001), and dyslipidemia (p = 0.025) were more prevalent in 15-18-year-old boys than girls.26575698
ObesityDeregulated Nutrient SensingThe mouse model of monosodium glutamate (MSG)-induced obesity was exploited as a model of obesity combined with insulin resistance.26577083
Congenital AbnormalityDeregulated Nutrient SensingSuboptimal vitamin B12 (B12) status has been associated with an increased risk of congenital anomalies, preterm birth, and childhood insulin resistance.26579949
Muscular Atrophy, Muscle fiber atrophy, Diabetes MellitusDeregulated Nutrient SensingMuscle fibre atrophy and immunoreactivity for AGEs, Atrogin-1 (a muscle atrophy marker) and phosphorylated AMP-activated protein kinase (AMPK) expressions were markedly increased in human skeletal muscles from patients with diabetes as compared with control subjects.26586640
Skeletal muscle atrophy, diabeticDeregulated Nutrient SensingAdvanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway.26586640
Endurance, Muscular Atrophy, muscle mass, diabeticDeregulated Nutrient SensingMoreover, in diabetic mice we found increased blood AGEs, less muscle mass, lower muscular endurance, atrophic muscle size and poor regenerative capacity, and increased levels of muscle AGE and receptor for AGE (RAGE), Atrogin-1 and phosphorylated AMPK, which could be significantly ameliorated by Ala-Cl.26586640
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingFasting insulin and insulin resistance index were greater in women with PCOS.26586671
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia and associated factors among the hypertensive population from rural Northeast China.26589291
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingHowever, we lack the latest data about the prevalence and epidemiological features of dyslipidemia among hypertensive residents in rural China.26589291
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia was dramatically high and dyslipidemia screening was in-need in all diagnosed hypertensive individuals.26589291
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of hypertension or dyslipidemia did not impact on survival in patients with diabetes (P > 0.1 for both).26589875
Dyslipidemias, Diabetes Mellitus, Heart Diseases, Cerebrovascular accident, Hypertension, CTCAEDeregulated Nutrient SensingA total of 93% were diagnosed with hypertension; 61%, diabetes; and 72%, dyslipidemia; 90% were overweight/obese; 33% had a history of heart disease; and 10% had a stroke.26593384
Ulcerative ColitisDeregulated Nutrient SensingAssessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.26595549
Ulcerative ColitisDeregulated Nutrient SensingSirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation is an unexplored therapeutic approach for the treatment of ulcerative colitis (UC).26595549
Ulcerative ColitisDeregulated Nutrient SensingPatients with mild to moderately active UC were blindly randomized to 50 mg or 500 mg daily of SRT2104, a selective activator of SIRT1, for 8 weeks.26595549
DyslipidemiasDeregulated Nutrient SensingHowever, patients who were not married, had dyslipidaemia, higher levels of total cholesterol and higher PHQ-9 scores had lower HRQoL.26596372
Diabetes MellitusDeregulated Nutrient SensingThe binding of AP-1, a heterodimer of c-Jun and c-Fos, is regulated by posttranslational modifications, and in diabetes, deacetylating enzyme, Sirt1, is inhibited.26599598
Diabetic Retinopathy, diabeticDeregulated Nutrient SensingIn vitro results were validated in the retina from diabetic mice overexpressing Sirt1, and in the retinal microvessels from human donors with diabetic retinopathy.26599598
Mitochondrial Damage, Diabetic Retinopathy, Diabetes MellitusDeregulated Nutrient SensingThus, in diabetes, due to Sirt1 inhibition, AP-1 is hyperacetylated, which increases its binding at MMP-9 promoter, and hence, activation of Sirt1 could inhibit the development of diabetic retinopathy by impeding MMP-9-mediated mitochondrial damage.26599598
Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity as a mediator of the influence of physical activity on insulin resistance in Spanish adults.26601643
Depression, CTCAE, Unipolar DepressionDeregulated Nutrient SensingPrevious studies suggest that insulin-sensitizing agents could play a significant role in the treatment of major depression, particularly depression in patients with documented insulin resistance or those who are resistant to standard psychopharmacological approaches.26602230
Depression, CTCAEDeregulated Nutrient SensingImprovement in depression was associated with improvement in glucose metabolism but only in patients with insulin resistance.26602230
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingType of dyslipidemia and achievement of the LDL-cholesterol goal in chronic kidney disease patients at the University Hospital.26604773
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThis study was conducted to evaluate the types of dyslipidemia affecting patients with CKD stages 3 and 4 and to determine whether these patients achieved LDL-C goal.26604773
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingWe performed a retrospective chart review of patients with CKD stage 3 or 4 and dyslipidemia who were followed-up at Siriraj Hospital between October 2011 and September 2012.26604773
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIn total, 150 patients with CKD stage 3 or 4 and dyslipidemia were recruited.26604773
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThus, a developmental plan for the management of dyslipidemia in patients with CKD should be implemented to increase their achievement of the LDL-C goal.26604773
Dyslipidemias, Kidney FailureDeregulated Nutrient SensingAlthough dyslipidemia is related to the pathogenesis of renal insufficiency, which routinely available lipid measure is more applicable in estimation of kidney function is still uncertain.26607500
LipolysisDeregulated Nutrient SensingHowever, in the entire cohort fat cell size correlated positively with the ratio of M1/M2 macrophages, TNF-a secretion, lipolysis and insulin resistance.26607638
Steatohepatitis, Fatty Liver DiseaseDeregulated Nutrient SensingGlucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease.26608256
Diabetic Nephropathy, InflammationDeregulated Nutrient SensingThis study was carried out to evaluate the effects of omega-3 fatty acid administration on markers of insulin resistance, lipid concentrations, biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN).26611718
Sleeplessness, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingInsomnia symptoms were generally not associated with dyslipidemia, but receipt of sleeping pills in the setting of insomnia was associated with elevated LDL-C. Further research is needed to confirm a possible link between sleeping pill use and dyslipidemia and to delineate if an association with atherosclerosis exists with specific types of sleeping pills or with all sedative medications more broadly.26612387
Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingIn addition, the -1031T>C TNFA polymorphism was associated with dyslipidemia in ACS in a Western Mexican population.26618233
Inflammation, AtherosclerosisDeregulated Nutrient SensingPositive association of plasma sCD36 with insulin resistance has been reported, and it has been proposed that sCD36 might represent a marker of macrophage activation and inflammation leading to atherosclerosis.26620683
Primary malignant neoplasmDeregulated Nutrient SensingImmunohistochemical expression of phosphorylated adenosine monophosphate-activated protein (p-AMPK), mitogen-activated protein kinase (p-MAPK), phospho (p)-p70S6K, cyclin E, phosphatase and tensin homolog were analyzed in primary breast cancer samples.26623720
NeoplasmsDeregulated Nutrient SensingOn the other hand, low levels of miR-34a or miR-143 may relieve MDM4 and SIRT1 or MDM2 respectively, which will sequester p53 indicating an indirect mode of p53 suppression in oral tumors.26625772
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingIntensive management of dyslipidemia in older patients with stable coronary heart disease may have beneficial effects on renal function and SUA.26625880
Diabetes MellitusDeregulated Nutrient SensingHigh osteoprotegerin (OPG) has been reported in association with insulin resistance and type 2 diabetes.26626139
Degenerative polyarthritis, Primary malignant neoplasm, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAssociations with osteoarthritis, cancer, diabetes, dyslipidemia and abnormal sleep duration persisted after adjustment for mental health.26627637
NeoplasmsDeregulated Nutrient SensingTumor and non-tumoral tissue samples were collected from all patients, and mRNA expression levels of SIRT1-7 (Sirt1.1, Sirt1.2, Sirt2, Sirt3, Sirt4, Sirt5, Sirt6, and Sirt7) were examined by real-time PCR.26631040
NeoplasmsDeregulated Nutrient SensingThe results showed that expressions of SIRT1.1, SIRT1.2, SIRT4, SIRT5, SIRT6, and SIRT7 mRNAs were unchanged in tumor tissues of BCC patients compared with non-tumoral tissue samples.26631040
Prediabetes syndrome, DyslipidemiasDeregulated Nutrient Sensingprediabetes and borderline dyslipidemia) was significantly higher in subjects with upper-normal WC on comparison with those with low WC.26631437
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe found better control of some risk factors (improved dyslipidemia, heart rate, and blood glucose in patients with diabetes) but worse blood pressure control.26631917
ARCN1 gene, Stomach Carcinoma, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia was an independent protective factor for both TB (adjusted HR 2.13, 95% CI 1.73-2.62, P < 0.001) and mortality (adjusted HR 1.11, 95% CI 1.08-1.15, P < 0.001) in gastric cancer patients.Old age, male sex, diabetes mellitus, and COPD were independent risk factors for TB in gastric cancer.26632751
DyslipidemiasDeregulated Nutrient SensingIncreased Visceral Adipose Tissue Is an Independent Predictor for Future Development of Atherogenic Dyslipidemia.26636177
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia is frequently observed in persons with a greater amount of visceral adipose tissue (VAT).26636177
DyslipidemiasDeregulated Nutrient SensingHowever, it is still uncertain whether VAT is independently associated with the future development of atherogenic dyslipidemia.26636177
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia was defined as one or more abnormalities in high-density lipoprotein (HDL) cholesterol, triglycerides, or non-HDL cholesterol levels.26636177
DyslipidemiasDeregulated Nutrient SensingBaseline and change in VAT were independent predictors for future development of atherogenic dyslipidemia.26636177
DyslipidemiasDeregulated Nutrient SensingHowever, BMI, waist circumference, and SAT were not associated with future development of atherogenic dyslipidemia.26636177
Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Carotid Artery Diseases, Hypertension, CTCAEDeregulated Nutrient SensingAge, hypertension, dyslipidemia and diabetes are common cardiovascular risk factors (CVRFs) that contribute to the development of atherosclerosis in cardiovascular system including carotid artery disease.26636669
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIndividual CVRF analysis shows that hypertension was more related to the degree of severity than dyslipidemia and diabetes with corresponding abnormal cIMT rates being 79.39%, 72.98% and 32.37%, respectively.26636669
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe percentage of abnormal cIMT in hypertensive patient group with dyslipidemia is significantly higher than the other groups (P< 0.05).26636669
Dyslipidemias, Cataract, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney DiseasesDeregulated Nutrient SensingThe patient's medical history included type II diabetes mellitus, hypertension, chronic kidney disease, dyslipidemia, cataract surgery, and total hip arthroplasty.26637513
Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Sarcopenia, ObesityDeregulated Nutrient SensingSarcopenia is associated with significant liver fibrosis independently of obesity and insulin resistance in nonalcoholic fatty liver disease: Nationwide surveys (KNHANES 2008-2011).26638128
Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Sarcopenia, ObesityDeregulated Nutrient SensingSarcopenia is associated with significant liver fibrosis in subjects with NAFLD, and the association is independent of obesity and insulin resistance.26638128
ETV3 wt AlleleDeregulated Nutrient SensingThese findings suggest that insulin resistance amplifies the association between childhood adiposity and adult MetS and underscore the importance of preventing both adiposity and insulin resistance in early life.26640243
Diabetes MellitusDeregulated Nutrient SensingRelationship of Hemoglobin A1c with b Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients.26640807
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor.26640891
Dyslipidemias, atheroscleroticDeregulated Nutrient SensingAn increasing number of epidemiological studies have identified a close relationship between dyslipidemia and atherosclerotic stroke.26642713
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingThere are few studies available regarding risk factors for specific subtypes of ischemic stroke, and in particular, there is little evidence about the role of dyslipidemia.26642713
Obesity, Abdominal, Units Of Measure - SiemensDeregulated Nutrient SensingLower abdominal obesity (waist circumference) and lower insulin resistance predicted prevalent MHO in male and female adolescents for both definitions (p < 0.01).26643813
Reduced Device Function, Chronic Kidney DiseasesDeregulated Nutrient SensingReduced renal function in patients with chronic kidney disease is linked to insulin resistance; and impairments in glucose homeostasis, as measured by HbA1c levels, are related to cardiovascular events.26644065
Dyslipidemias, Albuminuria, Chronic Kidney DiseasesDeregulated Nutrient SensingEffects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia.26645467
Cardiac complication, Dyslipidemias, Kidney Diseases, Chronic Kidney DiseasesDeregulated Nutrient SensingIn non-dialysis chronic kidney disease (CKD) patients with dyslipidemia, statin therapy is recommended to prevent cardiovascular complications.26645467
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia has been also shown to be an independent risk factor for the progression of CKD.26645467
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThis study was a randomized, open-label, and parallel-group trial consisted of a 12-months treatment period in non-dialysis CKD patients with alubuminuria and dyslipidemia.26645467
Dyslipidemias, Albuminuria, Chronic Kidney DiseasesDeregulated Nutrient SensingAlthough statin add-on therapy did not show additive renal protective effects, the diet therapy as well as the diet-plus-statin therapy could contribute to the reduction in plasma pentosidine in CKD patients with albuminuria and dyslipidemia.26645467
Thoracic Injuries, Traumatic injuryDeregulated Nutrient SensingTrauma significantly increased insulin resistance biomarkers, and the NMR spectral profile of the aged flies with trauma-induced thoracic injury resembled that of insulin-resistant chico mutant flies.26648055
Diabetes MellitusDeregulated Nutrient SensingIndividuals with insulin resistance, but without diabetes, exhibit an increased islet size because of an elevated number of both b and a cells.26649619
Diabetes MellitusDeregulated Nutrient SensingUnderstanding the mechanism(s) that underlies the adaptive response of the islet cells to insulin resistance is a potential approach to design tools to enhance functional b-cell mass for diabetes therapy.26649619
Polycystic Ovary SyndromeDeregulated Nutrient SensingRegional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance.26650926
Overweight, ObesityDeregulated Nutrient SensingThese results suggest that a direct association between mild insulin resistance and brain glucose hypometabolism independent of overweight or obesity can exist in young adults in their 20s.26650926
B-Lymphocytes, Hyperglycemia, Postprandial, Hypoinsulinaemia (disorder), GDC Disease Response TerminologyDeregulated Nutrient SensingIn this cohort of newly diagnosed T2DM subjects, DR is associated with reduced b-cell responsiveness, resulting from b-cell failure rather than insulin resistance, leading to fasting and postprandial hyperglycemia and hypoinsulinemia.26652932
Glucose Intolerance (disease)Deregulated Nutrient SensingInsulin resistance and glucose intolerance have been associated with increased plasma levels of branched-chain amino acids (BCAA).26653072
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDiscriminative Ability of Plasma Branched-Chain Amino Acid Levels for Glucose Intolerance in Families At Risk for Type 2 Diabetes.26653072
Glucose Intolerance (disease)Deregulated Nutrient SensingWe determined the discriminative ability of fasting BCAA levels for glucose intolerance in nondiabetic relatives of patients with T2DM of two different ethnicities.26653072
Glucose Intolerance (disease)Deregulated Nutrient SensingBCAA levels may serve as biomarkers for early development of glucose intolerance in these families.26653072
Endotoxemia, Diabetes MellitusDeregulated Nutrient SensingThe Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial.26655398
Chronic heart failureDeregulated Nutrient SensingCirculating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure.26656612
CarcinogenesisDeregulated Nutrient SensingAdiponectin, a 244-amino acid peptide hormone, is associated with insulin resistance and carcinogenesis.26656720
Cessation of life, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is a major risk factor to cardiovascular disease (CVD)--the leading cause of death worldwide.26656980
TG gene, Low-Density Lipoproteins, DyslipidemiasDeregulated Nutrient SensingStatin users (n=16,036) had a lower rate of low-density lipoprotein dyslipidaemia compared to non-medication users (3% vs 17%), whereas the prevalence of high-density lipoprotein (HDL) (20% vs 12%) and triglycerides (TG) (12% vs 7%) dyslipidaemia were higher in statin users.26656980
TG gene, DyslipidemiasDeregulated Nutrient SensingStatin users had a greater prevalence of HDL, TG and combined HDL-TG dyslipidaemia compared to non-medication users (OR 1.44, 95% CI 1.36 to 153), (OR 1.18, 95% CI 1.10 to 1.27) and (OR 1.30, 95% CI 1.22 to 1.38), respectively, (all p values<0.0001).26656980
Dyslipidemias, ObesityDeregulated Nutrient SensingAmong the CVD risk factors, obesity has the greatest effect on the prevalence of all types of dyslipidaemia.26656980
OverweightDeregulated Nutrient SensingIn fact, in overweight or obese participants, greater ASB consumption was significantly associated with improved indexes of insulin resistance and 2-h postload glucose.26661840
Prostate Cancer Outcomes Study, DyslipidemiasDeregulated Nutrient SensingThis mutation results in arginine to glutamine substitution at the protein level, while phenotypically this condition presents with a loss of body fat, insulin resistance, dyslipidaemia, and other features mimicking PCOS.26662654
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingOur case highlights the importance of assessment of adipose tissue distribution, as well as a significance of assessment of glucose tolerance and insulin resistance in the differential diagnosis of PCOS.26662654
NeoplasmsDeregulated Nutrient SensingSirtuin-1 (SIRT1), one member of the mammalian sirtuin family, has been suggested to play an essential role in the development and progression of many tumors.26662958
Malignant neoplasm of esophagusDeregulated Nutrient SensingHowever, the relationship between expression of SIRT1 and prognosis of esophageal cancer is still unknown.26662958
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingThis study aimed to investigate SIRT1 expression and its possible prognostic value in esophageal squamous cell carcinoma (ESCC).26662958
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingWestern blotting and real-time quantitative reverse transcription PCR (RT-PCR) were carried out to explore the expression of SIRT1 in four human ESCC cell lines, one human normal epithelial cell line, and clinical ESCC tissues.26662958
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingUnivariate and multivariate Cox regression analyses were performed to evaluate the correlation of SIRT1 expression with clinical features and prognosis of ESCC patients.26662958
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingBasal expression levels of SIRT1 protein in ESCC tumor tissues and cell lines were higher than those in the control groups.26662958
TNM Staging System, Squamous cell carcinoma of esophagusDeregulated Nutrient SensingIHC analysis showed that expression levels of SIRT1 protein significantly correlated with TNM stage and lymph node status of ESCC patients.26662958
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingHigh SIRT1 expression in ESCC could serve as an independent predictive biomarker for diagnosis and prognosis in ESCC patients.26662958
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingOverexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma.26662958
Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingRisk factors for cardiovascular disease included: hypertension, diabetes mellitus (DM), smoking, and dyslipidemia.26663649
DyslipidemiasDeregulated Nutrient SensingThere was no significant difference of variables between subjects with DM, smoking or dyslipidemia and without cardiovascular risk factors.26663649
Vascular Diseases, ObesityDeregulated Nutrient SensingWe have found that carotid EMT is associated with cIMT, obesity and insulin resistance and the assessment of carotid EMT may provide additional information concerning early vascular disease.26667397
Chronic Kidney Diseases, Dyslipidemias, Dental Plaque, Carotid Intima-Media ThicknessDeregulated Nutrient SensingGiven that multiple interactions were found between CKD stage and age, phosphate, smoking, dyslipidemia, body mass index, systolic BP (SBP), carotid intima-media thickness, plaque at baseline, uric acid, cholesterol, 25-hydroxy vitamin D (25OH vitamin D), and antiplatelet and phosphate binders use, the analysis was stratified by CKD stages.26668022
Dyslipidemias, Carotid Intima-Media Thickness, AtherosclerosisDeregulated Nutrient SensingIn dialysis, an interaction between body mass index and 25OH vitamin D was found, and age, dyslipidemia, carotid intima-media thickness, low cholesterol, ferritin, and uric acid were positively associated with atheromatosis progression.26668022
Steatohepatitis, ObesityDeregulated Nutrient SensingGly-MCA is a selective high-affinity FXR inhibitor that can be administered orally and prevents, or reverses, high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice.26670557
Steatohepatitis, Non-alcoholic Fatty Liver Disease, Fatty degeneration, DyslipidemiasDeregulated Nutrient SensingHepatic Steatosis and Insulin Resistance, But Not Steatohepatitis, Promote Atherogenic Dyslipidemia in NAFLD.26672634
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingPatients with NAFLD had severe insulin resistance, especially at the level of the adipose tissue, when compared with patients without NAFLD.26672634
Nonalcoholic Steatohepatitis, Hepatobiliary Disorder, ObesityDeregulated Nutrient SensingWe speculate that this lipoprotein profile is driven mostly by liver fat content and insulin resistance and appears not to be worsened by obesity or the severity of liver disease (nonalcoholic steatohepatitis).26672634
Steatohepatitis, Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingThe objective of the study was to determine the contribution of the severity of steatohepatitis to atherogenic dyslipidemia in patients with NAFLD.26672634
Hypertensive disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOlder age, higher BMI, diabetes mellitus, and dyslipidemia were associated with having HTN.26676023
DyslipidemiasDeregulated Nutrient SensingIn fully adjusted models with the 10 covariates, a significantly increased number of infarcted coronary arteries was identified in the highest quartile and quintile of TMAO compared to the lowest quartile (OR 11.9; 95 % CI 3.88-36.7, p <= 0.001) and quintile (OR 14.1; 95 % CI 3.88-51.2; p <= 0.001), respectively, independent of dyslipidemia.26676906
Hypertension, CTCAE, Obesity, Chronic active hepatitisDeregulated Nutrient SensingCAH has also been associated with obesity, insulin resistance, and hypertension.26677089
ARCN1 gene, Skeletal muscle weaknessDeregulated Nutrient SensingInsulin resistance is associated with skeletal muscle weakness in COPD.26678022
ARCN1 gene, Skeletal muscle weaknessDeregulated Nutrient SensingWe tested the hypothesis that insulin resistance contributes to skeletal muscle weakness in people with stable COPD.26678022
Quadriceps weaknessDeregulated Nutrient SensingOn multivariate analysis, with age, sex, weight, BODE index and step count per day included in the model, a one-unit increase in insulin resistance was associated with a 5.9 (2.0-9.8)-kg decrease in QMVC (P = 0.004) and a 4.2 (1.3-14.3)-fold increased risk of quadriceps weakness (P = 0.02).26678022
ARCN1 gene, Skeletal muscle weaknessDeregulated Nutrient SensingInsulin resistance is associated with skeletal muscle weakness in COPD, independent of potential confounders.26678022
SteatohepatitisDeregulated Nutrient SensingAdiposity and insulin resistance explained most of the association of mild hepatic steatosis and partially explained the association of moderate-severe hepatic steatosis with FSH.26678239
Dyslipidemias, Retinal Diseases, Kidney Diseases, ObesityDeregulated Nutrient SensingComorbidities were present more frequently in canagliflozin initiators: nephropathy (10.6% vs. 7.0%), retinopathy (10.4% vs. 7.5%), dyslipidemia (82.4% vs. 72.2%), and obesity (24.9% vs. 15.6%), respectively (P less than 0.001 for all comparisons).26679969
Dyslipidemias, ObesityDeregulated Nutrient SensingRegression analysis indicated that baseline insulin and glucagon-like peptide-1 use, as well as comorbid dyslipidemia and obesity, were significantly associated with the initiation of canagliflozin versus DPP-4 agents.26679969
TG gene, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is the risk factor of cardiovascular disease, but the relationship between the plasma triglyceride (TG) levels and total/cardiovascular mortality has not yet been analyzed in Slavs.26680668
physiopathological, "Huntingtons Disease PathwayDeregulated Nutrient SensingAMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.26681807
Neurodegenerative Disorders, Vascular System InjuriesDeregulated Nutrient SensingSeveral studies suggested that AMPK activation may improve energy metabolism and protein clearance in the brains of patients with vascular injury or neurodegenerative disease.26681807
HD Term Type, "Huntingtons Disease PathwayDeregulated Nutrient SensingHowever, in Huntington's disease (HD), AMPK may be activated in the striatum of HD mice at a late, post-symptomatic phase of the disease, and high-dose regiments of the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide may worsen neuropathological and behavioural phenotypes.26681807
Inflammation, Chronic Kidney DiseasesDeregulated Nutrient SensingAmong patients with CKD, inflammation, prothrombotic state, oxidative stress, glycated hemoglobin, insulin resistance and alkaline phosphatase are associated with an increased risk of PAD, independent of traditional risk factors.26682964
TG gene, Dyslipidemias, HypothyroidismDeregulated Nutrient SensingIt is known to induce central hypothyroidism as well as dyslipidemia including elevation of triglycerides (TG) and low-density lipoprotein cholesterol along with slight lowering of high-density lipoprotein cholesterol (HDL-C).26687705
Diabetes MellitusDeregulated Nutrient SensingSeveral experimental studies showed that magnesium intake improved insulin resistance and glucose uptake in diabetes patients.26689794
muscle massDeregulated Nutrient SensingThe AMPK-related kinase SNARK regulates muscle mass and myocyte survival.26690705
muscle cell differentiationDeregulated Nutrient SensingWe found that expression of a member of the AMPK-related kinase family, the SNF1-AMPK-related kinase (SNARK, also known as NUAK2), increased with muscle cell differentiation.26690705
Stanford Cancer Institute, SarcopeniaDeregulated Nutrient SensingAfter further adjustments for interleukin-6 and insulin resistance, central FM, waist circumference and sarcopenia were no longer significantly associated with SCI.26692280
Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingComparing pre-CPPT and post-CPPT, we did not find differences regarding age, gender, hypertension, dyslipidemia, diabetes, smoking, previous myocardial infarction, or Killip classification.26693879
Skeletal muscle structure, ObesityDeregulated Nutrient SensingObesity is associated with insulin resistance but not skeletal muscle dysfunction or all-cause mortality.26698153
Alzheimers DiseaseDeregulated Nutrient SensingImpairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.26698666
Impaired cognitionDeregulated Nutrient SensingClinical studies suggest a link between peripheral insulin resistance and cognitive dysfunction.26698666
Alzheimers Disease", Cognition Disorders, Data types - AddressDeregulated Nutrient SensingInterestingly, post-mortem analyses of Alzheimer disease (AD) subjects demonstrated insulin resistance in the brain proposing a role for cognitive deficits observed in AD.26698666
Obesity, Diabetes MellitusDeregulated Nutrient SensingHigh fat intake and impaired insulin signaling are often associated with obesity, diabetes and insulin resistance.26700141
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingHowever, PFOA, PFNA, and PFUA showed a potential protective effect against glucose intolerance and the risk of diabetes.26700417
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFemale sex (p < 0.001), advanced age (p = 0.029), lower educational level (p = 0.005), and cardiovascular factors (hypertension, dyslipidemia, diabetes, lack of systemic exercise) also appeared to negatively affect QoL.26700441
Fracture, Dyslipidemias, Increased vertebral heightDeregulated Nutrient SensingMore rapid vertebral height loss was predicted by dyslipidemia (b=0.36, p=.05), previous non-vertebral pathologic fracture related to MM (b=0.51, p=.01), and Durie-Salmon Stage III (b=0.66, p=.06).26704858
Amyotrophic Lateral Sclerosis, physiopathological, Diabetes MellitusDeregulated Nutrient SensingShe may have developed diabetes due to SOD1 dysfunction by the I113T SOD1 mutation, and severe insulin resistance induced by ALS.26707039
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingStatins Are Underutilized in Patients with Nonalcoholic Fatty Liver Disease and Dyslipidemia.26707137
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingClinical practice guidelines recommend statins to treat dyslipidemia in patients with NAFLD; however, the extent to which such patients receive statins has not been studied.26707137
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingWe conducted a structured medical record review to assess for appropriate statin use in patients in a Veterans Administration facility with dyslipidemia and NAFLD as well as a parallel cohort without NAFLD.26707137
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingOf 255 patients with NAFLD and dyslipidemia, 152 (59.6 %) patients received appropriate statin care.26707137
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingStatins are underused in patients with NAFLD and dyslipidemia.26707137
ObesityDeregulated Nutrient SensingLipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults.26709969
Obesity, Diabetes MellitusDeregulated Nutrient SensingIdentifying biomarkers will lead to a better understanding of the underlying mechanisms associated with obesity and the pathways leading to insulin resistance (IR) and diabetes.26709969
Breast Carcinoma, ObesityDeregulated Nutrient SensingObesity, insulin resistance, and elevated levels of circulating proinflammatory mediators are associated with poorer prognosis in early-stage breast cancer.26712688
Inflammation, Demographics Domain, Degenerative polyarthritis, Obesity, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity is a state of chronic inflammation that is associated with insulin resistance and type 2 diabetes mellitus (DM), as well as an increased risk of osteoarthritis (OA).26713606
Degenerative polyarthritis, Demographics DomainDeregulated Nutrient SensingWhile insulin plays a protective, antiinflammatory role in the synovium, insulin resistance in patients with type 2 DM may impair this protective effect and promote the progression of OA.26713606
CataractDeregulated Nutrient SensingSIRT1 or SIRT1 activators could potentially be used to prevent ocular aging and cataract in the future.26716364
Coronary Artery Disease, RestenosisDeregulated Nutrient SensingThe obesity-related hormones leptin and adiponectin are independently and oppositely associated with insulin resistance, which is an important risk factor for coronary artery disease (CAD) and restenosis after coronary intervention.26717211
ARCN1 gene, Cardiovascular Diseases, Dyslipidemias, Behavior Disorders, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingIt is important to screen patients at risk for COPD among those with lifestyle-related diseases such as hypertension, diabetes mellitus, and dyslipidemia, since these diseases promote the development of cardiovascular diseases closely associated with increased COPD mortality.26718143
NeoplasmsDeregulated Nutrient SensingAdenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that maintains energy homeostasis in both normal and cancerous cells, and has emerged as a tumor suppressor.26718214
Breast CarcinomaDeregulated Nutrient SensingLKB1/AMPK inhibits TGF-b1 production and the TGF-b signaling pathway in breast cancer cells.26718214
Breast CarcinomaDeregulated Nutrient SensingTaken together, our study demonstrates that AMPK exerts multiple actions on TGF-b signaling and supports that AMPK can serve as a therapeutic drug target for breast cancer.26718214
Myeloid Leukemia, ChronicDeregulated Nutrient SensingHere, we report that Sirtinol, a known SIRT1 inhibitor, induces premature senescence and growth arrest in K562 CML cells.26718407
AcneDeregulated Nutrient SensingPostadolescent male patients with acne more commonly have insulin resistance.26720707
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes is usually accompanied by dyslipidaemia, and among these triglyceride levels are related to the insulin resistance in type 2 diabetes.26721018
HyperglycemiaDeregulated Nutrient SensingRecent evidence suggests that Gal-3 may also be an important modulator of cardiometabolic traits such as adiposity, insulin resistance, and hyperglycemia.26722123
Liver CirrhosisDeregulated Nutrient SensingThese findings implied that there was a certain degree of insulin resistance and abnormal glucose metabolism in the patients with liver cirrhosis.26722544
Hypertension, CTCAE, Dyslipidemias, Prediabetes syndromeDeregulated Nutrient SensingVAT was associated with increased risk of hypertension (OR = 1*97, P < 0*0001), prediabetes (OR = 1*53, P = 0*0007) and dyslipidaemia (OR = 2*40, P < 0*0001).26725580
Hypertension, CTCAE, Dyslipidemias, Prediabetes syndromeDeregulated Nutrient SensingHigher VAT was associated with increased risk of hypertension, dyslipidaemia and prediabetes.26725580
ObesityDeregulated Nutrient SensingSerum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity.26727116
TG geneDeregulated Nutrient SensingSerum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated.26727147
TG geneDeregulated Nutrient SensingThese results suggest that changes in TG and SUA are synergistic factors associated with changes in insulin resistance after a 12-week walking exercise program in community-dwelling older women.26727147
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingSubjects with lower BNP quartiles had significantly elevated prevalence of dyslipidemia, including hypertriglyceridemia, hyper-LDL-emia and hypercholesterolemia.26728801
DyslipidemiasDeregulated Nutrient SensingThe elderly people with higher BNP levels have significantly reduced risks for nonfasting dyslipidemia.26728801
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPsychological Insulin Resistance in Patients with Type 2 Diabetes.26731825
Diabetes MellitusDeregulated Nutrient SensingTo identify risk factors associated with psychological insulin resistance (PIR) in Indian type 2 diabetes (T2DM) population.26731825
Nonalcoholic Steatohepatitis, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThese results may evidence that non-alcoholic steatohepatitis is associated with metabolic risk factors such as diabetes mellitus, dyslipidemia, and obesity.26732004
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients with diabetes mellitus and dyslipidemia had higher BMI values.26734799
Impaired cognition, Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Chronic Kidney DiseasesDeregulated Nutrient SensingSome differences in comorbidities were noted, with diabetes mellitus, dyslipidaemia, chronic renal failure and atrial fibrillation being more frequent in the RICA registry while cognitive and functional impairment predominated in the EAHFE registry.26739849
OverweightDeregulated Nutrient SensingRelative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals.26740597
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart diseaseDeregulated Nutrient SensingSelenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease.26743526
Diabetes MellitusDeregulated Nutrient SensingSerum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation.26743527
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingAn altered prenatal environment during maternal obesity predisposes offspring to insulin resistance, obesity, and their consequent comorbidities, type 2 diabetes and cardiovascular disease.26744506
Weight Gain, EndotoxemiaDeregulated Nutrient SensingThe gut microbiota plays an important role in human metabolism; previous studies suggest that the imbalance can cause a metabolic endotoxemia that may be linked to weight gain and insulin resistance.26745497
Dyslipidemias, Blood GlucoseDeregulated Nutrient SensingThis feature is attributable to a greater discrimination of patients with high blood pressure, glycemia, and dyslipidemia.26747228
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe risk factors for CAS were identified to be advanced age, history of smoking, diabetes mellitus, dyslipidaemia and presence of a carotid bruit.26750678
Arthritis, Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingPatients with late onset arthritis (LOA) were more likely to have DM (OR 4.0, P=0.009), hypertension (OR 2.5, P=0.004), dyslipidemia (OR 2.3, P=0.011), and obesity (OR 1.7, P=0.012).26750761
Weight decreasedDeregulated Nutrient SensingHDL-sphingomyelin reduction after weight loss by an energy-restricted diet is associated with the improvement of lipid profile, blood pressure, and decrease of insulin resistance in overweight/obese patients.26751808
Back PainDeregulated Nutrient SensingOur results indicated that SIRT1 exerted anti-inflammatory effects againstIL-1b-mediated degeneration of NP cells through the TLR2/SIRT1/NF-kB pathway, suggesting that it could be used as a potential candidate for treating IVDD-mediated back pain.26752489
Primary malignant neoplasm, Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingChildhood cancer survivors treated with haematopoietic stem cell transplantation (HSCT) and total body irradiation are at an increased risk of developing diabetes early in life due to insulin resistance and b-cell dysfunction, but the optimal screening method is unknown.26757409
Dyslipidemias, Diabetes Mellitus, Sleep Apnea, Obstructive, Comorbidity, Hypertension, CTCAEDeregulated Nutrient SensingComorbidity improvement and resolution were 98 % for obstructive sleep apnea, 79 % for diabetes mellitus, 87 % for dyslipidemia, and 85 % for hypertension.26757919
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is a known risk factor for developing cardiovascular disease.26758706
Cessation of life, DyslipidemiasDeregulated Nutrient SensingIn addition to traditional predictors of in-hospital death, statin-treated dyslipidemia was a favorable predictor of in-hospital mortality for STEMI and NSTEMI patients, whereas hemodialysis was the strongest predictor for NSTEMI patients.26758733
Increased insulin level, Thyroid carcinomaDeregulated Nutrient SensingStudies to investigate the specific effects of hyperinsulinemia and insulin resistance on thyroid cancer risk may provide additional information.26760177
ACSM3 gene, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of sedentary lifestyle was 44%, history family 50%, smoking 23%, overweight/obesity 68%, dyslipidemia (high cholesterol levels) 43%, SAH 40%, and diabetes 11%.26761368
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingWhen compared to the 2002 study, the prevalence of active smoking and sedentary behavior decreased, whereas the prevalence of hypertension, dyslipidemia and obesity increased.26761368
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHypertension, obesity and dyslipidemia are still prevalent and require major prevention programs.26761368
Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Haiti, Diabetes Mellitus, Hyperuricemia, Hua , Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingTo clarify the association between toothbrushing and risk factors for cardiovascular disease--namely, hypertension (HT), diabetes mellitus (DM), dyslipidaemia (DL), hyperuricaemia (HUA) and chronic kidney disease (CKD).26769787
Increased insulin level, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM).26770991
Dyslipidemias, Glaucoma, CTCAEDeregulated Nutrient SensingWe aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma.26773174
Diabetes Mellitus, Non-Insulin-Dependent, metabolic disturbanceDeregulated Nutrient SensingSkeletal muscle insulin resistance and oxidative stress are characteristic metabolic disturbances in people with type 2 diabetes.26774673
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingFindings implicate AA supplementation as a potentially inexpensive, convenient, and effective adjunct therapy in the treatment of insulin resistance in people with type 2 diabetes.26774673
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPatients with PLL had poor metabolic control and marked insulin resistance compared to subjects with type 2 diabetes.26776282
Lipodystrophy, Flinders medical centre-7 marker, Diabetes MellitusDeregulated Nutrient SensingOur data suggests that PLL is a relatively common form of lipodystrophy in diabetes clinics, which is associated with poor metabolic control and marked insulin resistance.26776282
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance is common in individuals with chronic kidney disease (CKD) and may be partly explained by modifiable risk factors.26776598
Chronic Kidney DiseasesDeregulated Nutrient SensingWe here explore the potential role of vitamin E as a modifiable risk factor for insulin resistance among individuals with CKD.26776598
ObesityDeregulated Nutrient SensingEpicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS.26777475
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThese patients were older (69.5y vs. 64.2y; p<0.001), more frequently male, with more risk factors (hypertension, dyslipidemia), and more comorbidities.26778745
Non-alcoholic Fatty Liver Disease, Fatty degenerationDeregulated Nutrient SensingHepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease.26780287
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingRecent data in mice have identified de novo ceramide synthesis as the key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in liver fat due to IR ('Metabolic NAFLD' but not that due to the I148M gene variant in PNPLA3 ('PNPLA3 NAFLD').26780287
Triglycerides, DyslipidemiasDeregulated Nutrient SensingHypertriacylglycerolaemia is a hallmark of diabetic dyslipidaemia with increased concentrations of triacylglycerol (TG)-rich VLDL1 particles.26781548
Hyperleucinemia, HyperinsulinismDeregulated Nutrient SensingHyperinsulinaemia and insulin resistance (but not hyperleptinaemia) are associated with augmented pressure response from chemoreceptors.26781642
Dyslipidemias, PsoriasisDeregulated Nutrient SensingTo our knowledge this study for the first time unveils that high level of intracellular cholesterol plays a crucial role in IL-17A signaling in keratinocytes and may explain the strong association between psoriasis and dyslipidemia.26781963
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingAccumulating evidence has linked elevated parathyroid hormone (PTH) with insulin resistance, beta cell dysfunction and dysglycaemia, however, its role in the development of diabetes is largely unclear, particularly among non-whites.26782010
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingRelative risks ranged from 1.07 (0.84-1.36) for having dyslipidemia to 4.65 (1.77-12.17) for having hypertension.26782636
Psoriasis, Dyslipidemias, Anemia, Asthma, Hypertension, CTCAE, EczemaDeregulated Nutrient SensingThe age-standardised prevalence of hypertension, dyslipidaemia, asthma, psoriasis, eczema and anaemia was significantly higher in the MS cohort compared to that in the general Australian population.26784322
DyslipidemiasDeregulated Nutrient SensingThe level of disability (Multiple Sclerosis Severity Score) in those who reported overweight/obesity (b: 0.76 (95% CI 0.04-1.48), p = 0.037), or dyslipidaemia (b: 1.05 (95% CI 0.07-2.02), p = 0.036) was significantly higher compared to those who did not report these comorbidities, even after adjustment for potential confounders.26784322
Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, dyslipidemia, diabetes, smoking, previous coronary artery disease and stroke were similar between the groups.26786608
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingType 2 diabetes is the most common form of diabetes some investigations show the association of lipoprotein-associated phospholipase A2 mass and activity with the incidence of cardiovascular disease (CVD) in populations with high prevalences of insulin resistance and diabetes.26786990
Coronary Artery DiseaseDeregulated Nutrient SensingExpression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease.26788516
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingStatins are prescribed to treat dyslipidemia (abnormal amount of lipids such as cholesterol and/or fat in the blood) and reduce cardiovascular disease (CVD) risk.26788719
Weight GainDeregulated Nutrient SensingEMPOWIR (Enhance the Metabolic Profile of Women With Insulin Resistance; NCT00618072) was a double-blind, placebo-controlled, 12-month trial of women with >20-pound weight gain, normal glucose tolerance test, and increased area-under-the-curve insulin.26789348
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingIn addition, serum irisin was inversely related to pre-diabetes/type 2 diabetes (T2D) independent of other risk factor for T2D and insulin resistance [OR (95 % CI); 0.66 (0.49-0.90), P = 0.009].26790404
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingParticipants presented a high prevalence of diabetes (18.5%), dyslipidemia (17.6%), gout/hyperuricemia (10.7%), overweight/obesity (68.8%), self-medication (37.5%), and alcohol consumption (33.3%).26791352
Glucose Intolerance (disease), ETV3 wt AlleleDeregulated Nutrient SensingAmong the components of MetS, over waist circumference and glucose intolerance were significantly associated with increased incidence of the composite endpoint (HR 1.23, P=0.038, and HR 1.29, P<0.001, respectively) in males but not in females.26794282
Inflammation, Dyslipidemias, OverweightDeregulated Nutrient SensingThis study is a preliminary clinical study to verify that GO could be beneficial for amelioration of obesity-related dyslipidemia, inflammation, and oxidative stress without side effect in the overweight or obese subjects.26796927
Decompensation, Diabetes MellitusDeregulated Nutrient SensingIn compensated HCV-related cirrhotic patients, diabetes and marked insulin resistance are independently associated with poorer overall survival and increased risk of hepatic decompensation.26797261
Renal Insufficiency, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingImpaired renal function causes dyslipidemia that contributes to elevated cardiovascular risk in patients with chronic kidney disease (CKD).26799206
Dyslipidemias, Diabetes Mellitus, Retinal Diseases, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingTwenty-one (91.3%) patients had the following systemic diseases: hypertension, diabetes mellitus without retinopathy, dyslipidemia, or chronic renal failure requiring dialysis.26800210
Multiple Myeloma, Waldenstrom Macroglobulinemia, Adult Non-Hodgkin LymphomaDeregulated Nutrient SensingTAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenstrom's macroglobulinemia.26800393
Endothelial dysfunction, Diabetes MellitusDeregulated Nutrient SensingEndothelial dysfunction is linked to insulin resistance, inflammatory activation, and increased cardiovascular risk in diabetes mellitus; however, the mechanisms remain incompletely understood.26800561
Endothelial dysfunction, Diabetes MellitusDeregulated Nutrient SensingOur findings demonstrate that noncanonical Wnt5a signaling and JNK activity contribute to vascular insulin resistance and endothelial dysfunction and may represent a novel therapeutic opportunity to protect the vasculature in patients with diabetes mellitus.26800561
Prediabetes syndrome, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance: The linchpin between prediabetes and cardiovascular disease.26802220
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIt has been suggested that insulin resistance may contribute to the increased risk of EC in PCOS.26802879
Dyslipidemias, Diabetes Mellitus, Heart failure, Chronic lung disease, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingCompared with cases performed from 2005 to 2006, CS-AMI patients receiving PCI from 2011 to 2013 were more likely to have diabetes, hypertension, dyslipidemia, previous PCI, dialysis, but less likely to have chronic lung disease, peripheral vascular disease, or heart failure within 2 weeks (p < 0.01).26803418
Inflammation, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia and low-grade inflammation are integral in the pathogenesis of atherosclerosis.26803431
DyslipidemiasDeregulated Nutrient SensingThese results suggest that checking for the presence or absence of resistance factors, including elevated HbA1c levels and dyslipidemia, may contribute to the appropriate usage of SITA.26804641
Glucose Intolerance (disease), Pancreatic FistulaDeregulated Nutrient SensingPostoperatively, the patient had no complications such as pancreatic fistula or aggravation of glucose intolerance.26805362
Dyslipidemias, ETV3 wt Allele, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingDyslipidemia is an important factor in MetS and is related to atrial fibrillation (AF).26805814
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingCorrelation between non-alcoholic fatty liver disease (NAFLD) and dyslipidemia in type 2 diabetes.26810159
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingDyslipidemia in patients with NAFLD is atherogenic in nature and it is characterized by increased levels of serum triglycerides and decreased levels of HDL cholesterol.26810159
Weight decreasedDeregulated Nutrient SensingEffects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women.26811166
Weight decreasedDeregulated Nutrient SensingThe distribution of energy from carbohydrate and fat has been observed to promote differential plasma lipid responses in previous weight loss studies, and insulin resistance status may interact with diet composition and affect weight loss and lipid responses.26811166
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingSince dyslipidaemia is one of the most important risk factors for coronary heart disease (CHD), lowering of LDL-cholesterol (LDL-C) causes significant reduction in morbidity and mortality, particularly in patients with established CHD.26812002
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingToo many CHD patients with dyslipidaemia are still inadequately treated and most of these patients on statin therapy are not achieving the treatment targets.26812002
Prediabetes syndromeDeregulated Nutrient SensingHowever, PSE was unrelated to prediabetes, insulin resistance, or visceral fat.26812049
Fatty degenerationDeregulated Nutrient SensingPrevalence of steatosis was higher among those who had larger waist circumference, insulin resistance, higher HDL cholesterol and a history of antiretroviral therapy.26812065
Hepatobiliary Disorder, Fatty degeneration, Hepatitis CDeregulated Nutrient SensingWe observed a high burden of liver disease in this relatively young cohort that was primarily driven by chronic HCV infection, metabolic factors (insulin resistance and steatosis) and heavy alcohol use.26812065
Prostate Cancer Outcomes Study, Thyroid stimulating hormone measurementDeregulated Nutrient SensingHowever, we did not find a direct dependency of TSH indicators of insulin resistance neither across the group of women with PCOS, nor with the subgroups.26817257
AtherosclerosisDeregulated Nutrient SensingDespite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive predictor of cardiovascular mortality.26817832
Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingThe prevalence of comorbidities increased in parallel with BMI and included arterial hypertension, diabetes mellitus, dyslipidaemia (all P < 0.001), chronic obstructive pulmonary disease (P = 0.041) and chronic kidney disease (P = 0.056).26817848
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAdult participants with dyslipidemia (p < 0.01), prediabetes/diabetes (p = 0.04), and hypertension (p = 0.02) were significantly more likely to obtain lipid monitoring.26818535
Cheilitis, Dyslipidemias, Photosensitivity of skin, XerosisDeregulated Nutrient SensingSeveral side effects of acitretin have been reported such as teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity.26820109
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingDuring follow-up, he developed hyperglycemia and dyslipidemia, which were controlled by increasing leptin dose and starting oral antidiabetic drugs.26821845
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypothyroidism, Lung Diseases, ObstructiveDeregulated Nutrient SensingDrugs for cardiovascular diseases, dyslipidemia, diabetes mellitus, hypothyroidism and obstructive pulmonary disease were more frequently purchased than in the sex- and age-adjusted population, with rate ratios ranging from 1.6 to 7.8.26821964
Dyslipidemias, Demographics DomainDeregulated Nutrient SensingThere was no significant difference between both groups regarding age, presence of DM, and dyslipidemia.26828751
Diabetes MellitusDeregulated Nutrient SensingSpecific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes.26829444
Diabetes Mellitus, Non-Insulin-Dependent, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8Deregulated Nutrient SensingInsulin resistance reflects the inadequate insulin-mediated use of metabolites and predicts type 2 diabetes (T2D) but is also frequently seen in long-standing type 1 diabetes (T1D) and represents a major cardiovascular risk factor.26829444
Diabetes MellitusDeregulated Nutrient SensingWe hypothesized that plasma metabolome profiles allow the identification of unique and common early biomarkers of insulin resistance in both diabetes types.26829444
Acquired Immunodeficiency Syndrome, HIV Infections, AtherosclerosisDeregulated Nutrient SensingComparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study).26830260
HIV, Coronary Artery DiseaseDeregulated Nutrient SensingThe relation between insulin resistance (IR) and coronary artery disease in patients with human immunodeficiency virus (HIV) infection remains incompletely defined.26830260
Thrombolysis, function, Cerebrovascular accidentDeregulated Nutrient SensingHigher Insulin Resistance Level is Associated with Worse Clinical Response in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis.26830777
Atherosclerosis, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance is linked to atherosclerotic cardiovascular diseases and stroke.26830777
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingAmong 823 obese patients, 353 (42.9%) met the dyslipidemia criteria: 21.7% had hypertriglyceridemia, 19.7% had low levels of HDL-C, 18.6% had hypercholesterolemia, and 13.7% had high levels of LDL-C.26831558
DyslipidemiasDeregulated Nutrient SensingOlder age and/or high body mass index (BMI) were related to increased prevalence of dyslipidemia.26831558
DyslipidemiasDeregulated Nutrient SensingPatients with both dyslipidemia and grade 2-3 hepatosteatosis had higher levels of ALT, AST and TSH and lower levels of fT4.26831558
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia is high in obese children, and hypertriglyceridemia is in the foreground.26831558
Dyslipidemias, Liver DysfunctionDeregulated Nutrient SensingHigher levels of IR and more apparent abnormal liver function test results are observed in the context of dyslipidemia and hepatosteatosis coexistence.26831558
Steatohepatitis, DyslipidemiasDeregulated Nutrient SensingMetabolic and hormonal alterations related with thyroid functions may also be associated with dyslipidemia and hepatosteatosis in obese patients.26831558
Malignant Head and Neck NeoplasmDeregulated Nutrient SensingStabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers.26832959
Demographics Domain, ObesityDeregulated Nutrient SensingFurther, we found that elevated serum GGT and ALT levels were significantly positively correlated with the prevalence of DM, independent of central obesity, serum lipid and insulin resistance (IR) in both genders.26838740
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingTo the contrary, respondents with hypercholesterolemia less often knew that dyslipidemia is a CVD risk factor than patients with normal cholesterol levels (24.1% vs 41.1%, p = 0.0108).26839239
Endothelial dysfunctionDeregulated Nutrient SensingAsymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.26840628
Endothelial dysfunction, ObesityDeregulated Nutrient SensingThe presence of insulin resistance (IR) is determinant for endothelial dysfunction associated with obesity.26840628
Endothelial dysfunction, ObesityDeregulated Nutrient SensingInsulin resistance (IR) is determinant for endothelial dysfunction in human obesity.26840628
Arteriosclerosis, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThey had arteriosclerosis risk factors, such as current smoking (16.2%), hypertension (61.5%), diabetes mellitus (38.3%) and dyslipidemia (38.8%).26841805
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingAlthough NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood.26843485
Fatty Liver, Glucose Intolerance (disease), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHere we demonstrate that p38d is elevated in livers of obese patients with NAFLD and that mice lacking p38g/d in myeloid cells are resistant to diet-induced fatty liver, hepatic triglyceride accumulation and glucose intolerance.26843485
Diabetes MellitusDeregulated Nutrient SensingOur findings verified the close correlation of BCAAs and AAAs with insulin resistance and future development of diabetes in Chinese populations and highlighted the predictive value of these markers for future development of diabetes.26846565
Sleep Apnea, ObstructiveDeregulated Nutrient SensingImpact of obstructive sleep apnoea on insulin resistance in nonobese and obese children.26846822
Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingObstructive sleep apnoea (OSA) has been inconsistently associated with insulin resistance and adverse metabolic states.26846822
Slow shallow breathing, Obesity, Osage languageDeregulated Nutrient SensingIn children with mild OSA, the presence of obesity increased the odds for insulin resistance, while higher apnoea/hypopnoea index values emerged among obese children who were more insulin-resistant.The exclusive presence of interactions between OSA and obesity in the degree of insulin resistance is coupled with synergistic contributions by sleep fragmentation to insulin resistance in the context of obesity.26846822
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA significant correlation was found between PWV and age (r = 0.67, p < 0.001), Framingham risk score (r = 0.61, p < 0.001), waist to hip ratio (r = 0.45, p < 0.001), systolic blood pressure (r = 0.37, p = 0.01), diabetes (r = 0.32, p = 0.001) and dyslipidemia (r = 0.32, p = 0.001).26852242
Dyslipidemias, Coronary Arteriosclerosis, Breast CarcinomaDeregulated Nutrient SensingPatients with breast cancer, obese patients, and those with dyslipidaemia and ischaemic heart disease were more likely to have increased HbA1c.26853192
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingInsulin resistance (IR) is a main pathophysiologic feature in polycystic ovary syndrome (PCOS) patients which is triggered by elevated oxidative stress in these patients.26854246
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingThis study showed that selenium supplementation in PCOS patients may worsen insulin resistance in them.26854246
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThorough physical and laboratory examination were performed at baseline (also the cross-sectional survey) to identify the risk factors such as hypertension, dyslipidemia, diabetes, as well as newly defined risk factors like elevated homocysteine, high sensitivity C-reactive protein, and urine micro-albumin.26854473
Dyslipidemias, Hypertension, CTCAE, Chest Pain, diabeticDeregulated Nutrient SensingDiabetic patients were older (P = .10), had a higher frequency of hypertension (P < .01) and dyslipidemia (P = .03), and had a trend to a longer time from the onset of chest pain to hospital arrival (P = .08).26856212
ObesityDeregulated Nutrient SensingLeptin-induced phospho-STAT3 and phospho-AMPK levels were similar to those in B cells from individuals with obesity.26857091
Hyperlipidemia, Hypertension, CTCAE, ComorbidityDeregulated Nutrient SensingNearly all patients (99.2%) suffered from at least one comorbidity, with hypertension (95.8%) and hyperlipidemia/dyslipidemia (78.3%) being the most prevalent.26857244
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingSimilar values were obtained in patients with and without metabolic comorbidities, such as diabetes, obesity and dyslipidemia (sensitivity 85%, specificity 88% and sensitivity 76%, specificity 94%, respectively).26857451
Dyslipidemias, Calcification of the aortaDeregulated Nutrient SensingCardiovascular risk factors (blood pressure, dyslipidemia, cigarette smoking) and radiological data (maximum aneurism diameter, intra-luminal thrombus, aortic wall calcification) increased these changes.26858185
Diabetes MellitusDeregulated Nutrient SensingGlucose Complexity Estimates Insulin Resistance in Either Nondiabetic Individuals or in Type 1 Diabetes.26859105
Diabetes MellitusDeregulated Nutrient SensingIn long-standing type 1 diabetes, the inverse correlation between glucose entropy and insulin resistance is preserved, as lower glucose entropy is associated with higher BMI.26859105
Aneurysm, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingAge, sex, smoking, dyslipidemias, or controlled arterial hypertension had no influence on aneurysm progression rate.26859744
Acanthosis NigricansDeregulated Nutrient SensingClinicians should be aware of this rare manifestation, because newly diagnosed acanthosis nigricans should prompt examination for insulin resistance.26860419
Ovarian CarcinomaDeregulated Nutrient SensingOverexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.26862948
Malignant NeoplasmsDeregulated Nutrient SensingIn contrast, SIRT1 may be oncogenic because its overexpression has been detected in many cancers.26862948
OVCAR-3, Ovarian CarcinomaDeregulated Nutrient SensingThe aim of the present study was to clarify the expression and the role of SIRT1 in ovarian carcinoma (OvCa).26862948
Mucinous, Adenocarcinoma, Clear Cell, Endometrioid tumor, Serous CystadenocarcinomaDeregulated Nutrient SensingThe expression of SIRT1 was higher in endometrioid, mucinous, and clear-cell carcinomas than in the inclusion cysts of normal ovaries, but not in serous carcinoma (P=0.038).26862948
Neoplasm Metastasis, OVCAR-3Deregulated Nutrient SensingThe expression of SIRT1 on OvCa did not correlate with age, stage, location of metastasis, or capsular penetration.26862948
NeoplasmsDeregulated Nutrient SensingHowever, elevated SIRT1 expression was a significant predictor of shorter survival in univariate (P=0.038) and multivariate (P=0.037) survival analyses, regardless of the tumor stage.26862948
OVCAR-3Deregulated Nutrient SensingResults of the present study suggest a positive role for SIRT1 in the development of OvCa and its potential as a novel therapeutic target.26862948
Refractory anemias, ETV3 wt AlleleDeregulated Nutrient SensingThe serum RA level is inversely associated with the development of MetS independently of adiposity and insulin resistance.26863424
ETV3 wt AlleleDeregulated Nutrient SensingA key component of MetS is the development of insulin resistance (IR).26863426
Dyslipidemias, Chronic diseaseDeregulated Nutrient SensingLow levels of food security are associated with dyslipidemia and chronic disease in adults, particularly in women.26866948
Dyslipidemias, Chronic diseaseDeregulated Nutrient SensingThere is a gap in knowledge about the relationship between food security among youth and dyslipidemia and chronic disease.26866948
DyslipidemiasDeregulated Nutrient SensingIn this nationally representative sample, low-income adolescents living in households with marginal food security had increased odds of having a pattern consistent with atherogenic dyslipidemia, which represents a cardiometabolic burden above their risk from adiposity alone.26866948
Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is a hallmark of type 2 diabetes (T2DM), it is often accompanied by defective beta-cell function (BF) and is involved in the pathophysiology of cardiovascular disease (CVD).26868433
Dyslipidemias, Retinal Diseases, Depression, CTCAEDeregulated Nutrient SensingDM 1 patients had a mean QoL score of 0.7369, with retinopathy, depression, dyslipidemia and a serious hypoglycemic crisis significantly reducing QoL.26873164
Primary malignant neoplasm, Neuropathy, Dyslipidemias, Depression, CTCAE, Hypertension, CTCAEDeregulated Nutrient SensingPatients with DM type 2 had a mean QoL score of 0.6582, with hypertension, neuropathy, depression, cancer and dyslipidemia significantly reducing QoL.26873164
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingMultivariate determinants of higher anterior circulation IMR in DM were dyslipidaemia, hypertension, worsening glycaemic control, and higher body mass index; metformin had a protective effect.26874336
Inflammation, Cytomegalovirus, Blood Vessel, Impaired cognitionDeregulated Nutrient SensingTo address the role of CMV, we investigated univariate and multivariate associations between markers of systemic and endothelial inflammation, vascular damage, insulin resistance (IR), neurocognitive decline, and antibodies reactive with CMV.26876416
Abnormal renal function, Communicable Diseases, DyslipidemiasDeregulated Nutrient SensingConcurrently, recipients with a low cTAC (< 5.89 ng/mL) were less likely to become obese (21.3% vs 30.2%, P < 0.05) or to develop dyslipidemia (27.5% vs 44.8%, P <0.05), chronic kidney dysfunction (14.6% vs 22.7%, P < 0.05), and moderate to severe infection (24.7% vs 33.1%, P < 0.05) after LT than recipients in the high mean cTAC group.26877618
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingResistin is an adipocyte- and monocyte-derived cytokine that represents a link between obesity, insulin resistance, and type 2 diabetes.26882819
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe effect of hypolipidemic treatment on monocyte cytokine release in different age groups of patients with type 2 diabetes and atherogenic dyslipidemia.26884290
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study retrospectively analysed the results of 65 patients with type 2 diabetes and atherogenic dyslipidaemia, complying with lifestyle intervention, and receiving metformin.26884290
Prediabetes syndromeDeregulated Nutrient SensingFurthermore, we found that high body mass index (p < 0.01) and fat mass (p < 0.01) and low adiponectin (p < 0.05) levels have roles in the development of insulin resistance in the prediabetic group.26884292
ObesityDeregulated Nutrient SensingWe suggested that in the prediabetic period not only obesity but also decreased adiponectin levels play some role in the pathogenesis of insulin resistance.26884292
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingHypertension and dyslipidemia correlated with lipid oxidation in children with CKD.26885251
Dyslipidemias, ObesityDeregulated Nutrient SensingThe most prevalent risk factors were dyslipidemia (70.9%), and central obesity (39.8%), followed by excess weight (29.6%), and high blood pressure (12.8%).26886094
Dyslipidemias, ObesityDeregulated Nutrient SensingExcess weight, central obesity, and dyslipidemia were common risk factors in the clustering patterns that showed higher-than-expected prevalence.26886094
Dyslipidemias, ObesityDeregulated Nutrient SensingClustering of risk factors (>= two factors) among the adolescents showed considerable prevalence, and there was a non-casual coexistence of excess weight, central obesity, and dyslipidemia (mainly low HDL-cholesterol).26886094
Cerebrovascular Disorders, Electrocardiogram: myocardial infarction (finding), Cerebrovascular accidentDeregulated Nutrient SensingThe identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients with cerebrovascular disease.26886418
Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus, Cerebrovascular accident, Tacca leontopetaloides, Ischemic strokeDeregulated Nutrient SensingIn this trial involving patients without diabetes who had insulin resistance along with a recent history of ischemic stroke or TIA, the risk of stroke or myocardial infarction was lower among patients who received pioglitazone than among those who received placebo.26886418
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingDoppler and conventional US were performed in 49 healthy volunteers, without risk factors for nonalcoholic fatty liver disease (NAFLD), and in 49 patients with NAFLD and at least one risk factor: obesity, dyslipidemia and/or diabetes mellitus.26887796
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe investigated the association of electrocardiographic (ECG) abnormalities with markers of insulin resistance and pancreatic beta-cell dysfunction in a cross-sectional study of type 2 diabetes patients.26889668
diabetic, Ventricular hypertrophyDeregulated Nutrient SensingIn type 2 diabetic patients, both oral glucose tolerance testing-derived and HOMA-derived measures of insulin resistance were associated with pathologic Q-waves and left ventricular hypertrophy on ECGs.26889668
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTwo patients had diabetes and 10 had dyslipidemia.26891003
Bipolar DisorderDeregulated Nutrient SensingVisceral Fat Accumulation, Insulin Resistance, and Elevated Depressive Symptoms in Middle-Aged Japanese Men.26891344
Bipolar DisorderDeregulated Nutrient SensingTo investigate visceral fat accumulation and markers of insulin resistance in relation to elevated depressive symptoms (EDS).26891344
Cancer-related fatigue, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is one ofthe CRF associated with numbers of cardiovascular diseases.26891515
Aggressive courseDeregulated Nutrient SensingWe found that BCOb present increased fasting blood glucose, insulin, resistin and monocyte chemoattractant protein 1, insulin resistance and more aggressive tumours.26892376
glucose metabolism, Breast CarcinomaDeregulated Nutrient SensingAltogether, our results suggest that glucose dysmetabolism, insulin resistance and changes in adipokine secretion, in particular resistin, may be involved in the development and progression of breast cancer in overweight/obese pre- and postmenopausal women.26892376
Myocardial Reperfusion, Chest PainDeregulated Nutrient SensingInsulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects.26892461
Diabetes MellitusDeregulated Nutrient SensingWe hypothesized that insulin resistance could play a role in this population even without diagnosed diabetes.26892461
Myocardial Reperfusion, Endothelial dysfunction, Chest PainDeregulated Nutrient SensingInsulin resistance measured by HOMA-IR is associated with endothelial dysfunction and confers independent prognostic information in non-diabetic patients with chest pain without myocardial perfusion defects.26892461
Heart failure, diabeticDeregulated Nutrient SensingThe impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure.26892514
Diabetes MellitusDeregulated Nutrient SensingHF and diabetes tend to worsen with each other; however, the appearance of an association between them was likely blunted due to the considerable effect of NP in counteracting insulin resistance, even during the metabolically harmful condition of HF.26892514
Diabetes MellitusDeregulated Nutrient SensingThis study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism.26892517
InflammationDeregulated Nutrient SensingIn this study, we aim to determine the interactive impact on VLDL profiles from insulin resistance, impairment in liver synthetic function and inflammation.26892520
DyslipidemiasDeregulated Nutrient SensingLiving in a less affluent neighborhood contributes to higher mortality among dyslipidemia patients.26895648
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and T2D are associated with insulin resistance and endogenous hyperinsulinemia and are more common in Black women.26896340
Increased insulin level, Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingWe hypothesize that insulin resistance and endogenous hyperinsulinemia in Black women with breast cancer contribute to their greater breast cancer mortality and are associated with increased insulin receptor signalling in tumours.26896340
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingIt may provide the basis for targeting systemic insulin resistance and/or tumour insulin receptor signalling to reduce racial disparities in breast cancer mortality.26896340
Inflammation, Fibrosis AssessmentDeregulated Nutrient SensingRegarding the stage of fibrosis, patients with advanced fibrosis were older and had more insulin resistance and more inflammation compared with patients that had mild fibrosis.26896689
palladiumDeregulated Nutrient SensingDecreased insulin resistance and suspected enhanced glucose stimulated insulin secretion decreasing PP2 seem to contribute improved glucose homeostasis after PD.26899541
Degenerative polyarthritisDeregulated Nutrient SensingCalcar Sirt1 expression was significantly reduced, while sclerostin was markedly increased in OP compared to OA patients.26902093
Fracture, Osteoporotic FracturesDeregulated Nutrient SensingReduced femoral neck Sirt1 may play a role in osteoporotic hip fractures in part via influencing local sclerostin expression.26902093
OsteoporosisDeregulated Nutrient SensingThe therapeutic potential of Sirt1 activation in osteoporosis warrants further investigation.26902093
Sleep Apnea, ObstructiveDeregulated Nutrient SensingCirculating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea.26904688
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese findings, from the first human study to investigate an association of PPI or H1RA/H2RA use with NAFLD, suggest that H2RA use may be associated with a lower prevalence of NAFLD, primarily among men with insulin resistance.26905606
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAnalysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or >=two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women.26907312
Dyslipidemias, Dysglycemia, ObesityDeregulated Nutrient SensingMetabolic dysregulation underlies key metabolic risk factors--obesity, dyslipidemia, and dysglycemia.26908103
Cardiovascular Diseases, Dyslipidemias, Dysglycemia, Diabetes Mellitus, ObesityDeregulated Nutrient SensingCross-sectional samples with or without obesity, dysglycemia, and dyslipidemia, excluding prevalent cardiovascular disease and diabetes or dyslipidemia treatment.26908103
Dyslipidemias, Dysglycemia, ObesityDeregulated Nutrient SensingCross-sectional associations with obesity, dyslipidemia, and dysglycemia were tested in discovery, with external replication of 37 metabolites.26908103
Dyslipidemias, Dysglycemia, ObesityDeregulated Nutrient SensingCross-sectional metabolite associations were identified with obesity (n = 26), dyslipidemia (n = 21), and dysglycemia (n = 11) in discovery.26908103
Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingPrevious research has suggested that activation of the renin-angiotensin-aldosterone system may promote insulin resistance and b-cell dysfunction, but the association with incident diabetes in African Americans is unknown.26908112
Diabetes MellitusDeregulated Nutrient SensingWe examined the association of aldosterone and renin with insulin resistance, b-cell function, and incident diabetes in a large African American cohort.26908112
Diabetes MellitusDeregulated Nutrient SensingActivation of the renin-angiotensin-aldosterone system may play a significant role in the development of insulin resistance and diabetes in African Americans.26908112
Glucose Intolerance (disease), HypoxiaDeregulated Nutrient SensingGlucose intolerance associated with hypoxia in people living at high altitudes in the Tibetan highland.26908520
Glucose Intolerance (disease), Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingTo clarify the association between glucose intolerance and high altitudes (2900-4800 m) in a hypoxic environment in Tibetan highlanders and to verify the hypothesis that high altitude dwelling increases vulnerability to diabetes mellitus (DM) accelerated by lifestyle change or ageing.26908520
Glucose Intolerance (disease), Polycythemia, HypoxemiaDeregulated Nutrient SensingAfter adjusting for lifestyle change, hypoxaemia and polycythaemia were closely associated with glucose intolerance.26908520
Glucose Intolerance (disease), HypoxemiaDeregulated Nutrient SensingSocioeconomic factors, hypoxaemia and the effects of altitudes >3500 m play a major role in the high prevalence of glucose intolerance in highlanders.26908520
Glucose Intolerance (disease), PolycythemiaDeregulated Nutrient SensingTibetan highlanders may be vulnerable to glucose intolerance, with polycythaemia as a sign of poor hypoxic adaptation, accelerated by lifestyle change and ageing.26908520
Weight Gain, Metabolic DiseasesDeregulated Nutrient SensingWestern dietary pattern predisposes to weight gain, insulin resistance and cardiometabolic diseases.26910624
Prediabetes syndrome, DyslipidemiasDeregulated Nutrient SensingSome obese children do not show cardiometabolic complications such as prediabetes, dyslipidemia or insulin resistance.26910741
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingOur results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway.26912037
Units Of Measure - Siemens, ObesityDeregulated Nutrient SensingParticipants were classified as MHO or of metabolically unhealthy obesity based on insulin resistance (IR) or cardiometabolic risk (CR) factors (blood pressure, lipids, and glucose).26913634
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingSignificant differences were found between the groups in regard to glycosylated hemoglobin, low density lipoprotein, systolic blood pressure, dyslipidemia, chronic renal failure, and disease duration.26914484
ObesityDeregulated Nutrient SensingWhether these lipid alterations are a reflection of insulin resistance or obesity remains unclear.26916476
ObesityDeregulated Nutrient SensingThe sphingolipid metabolism gene pathway was upregulated in muscle in insulin resistance independent of obesity.26916476
Hepatitis A, Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, hepatotoxin, Obesity, Arthritis, PsoriaticDeregulated Nutrient SensingAmong these, 393 patients with relevant laboratory data were analysed for liver enzymes and their relation to the known risk factors for liver disease (obesity, diabetes mellitus, alcohol consumption, hepatotoxic medications, dyslipidemia, psoriatic arthritis and infectious hepatitis).26916498
Carotid Intima-Media Thickness, Dyslipidemias, Endothelial dysfunction, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia, carotid intima-media thickness and endothelial dysfunction in children with chronic kidney disease.26921213
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingInformation on the association of these parameters with dyslipidemia in pre-dialysis pediatric CKD is limited.26921213
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOn multivariate analysis, hypertension (OR 3.68, P = 0.044) and male gender (OR 10.21, P = 0.004) were associated with dyslipidemia; cIMT was significantly associated with LDL cholesterol (b = 28.36, P = 0.033).26921213
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia was prevalent and cIMT significantly elevated in pre-dialysis pediatric CKD, indicating increased cardiovascular risk.26921213
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingElevated LDL cholesterol predicted increased cIMT, strengthening the association between dyslipidemia and atherosclerosis in early CKD.26921213
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingFor males and females, dyslipidemia and hypertension were not associated with psychological distress after adjusting for other factors.26921653
Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingAtherogenic dyslipidemia is common in type 2 diabetes (T2DM) and predicts cardiovascular disease, but information on the association of its components with atherosclerosis is scarce.26921744
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe assessed 96 T2DM patients (median age 63 years, 44% women, 19% smokers, 54% hypertension, 38% dyslipidemia) and 90 non-diabetic controls matched for age, sex, and cardiovascular risk factors.26921744
Hyperglycemia, Dyslipidemias, Malignant NeoplasmsDeregulated Nutrient SensingLifestyle-related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers.26923095
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingInsulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear.26923398
Obesity, Dyslipidemias, ETV3 wt Allele, Diabetes MellitusDeregulated Nutrient SensingBaseline characteristics associated with an increased risk of incident MCI were MetS (hazard ratio [HR], 1.46; 95% CI, 1.02-2.09), central obesity (HR, 1.41; 95% CI, 1.01-1.98), diabetes mellitus (HR, 2.84; 95% CI, 1.92-4.19), dyslipidemia (HR, 1.48; 95% CI, 1.01-2.15), and 3 or more component cardiovascular risk factors (HR, 1.58; 95% CI, 1.13-2.33).26926205
physiopathological, diabeticDeregulated Nutrient SensingUnder diabetic conditions, inadequate autophagy promotes cellular dysfunction and insulin resistance in non-vascular tissue.26926601
ACSM3 gene, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThe major risk factors for stroke are obesity, diabetes mellitus, systemic arterial hypertension (SAH) and dyslipidemia.26927647
Dyslipidemias, Tobacco DependenceDeregulated Nutrient SensingBrief report of virtual clinician research tools for tobacco dependence or dyslipidemia.26929166
Prediabetes syndromeDeregulated Nutrient SensingWe found significantly higher levels in patients with insulin resistance compared to those without (6.4 +- 3.7 vs. 4.1 +- 2.4 ng/ml, r = 0.025) and only a tendency toward higher levels in prediabetes compared to normoglycemic patients (5.9 +- 3.6 vs. 5.3 +- 3.4 ng/ml).26934129
Burn injuryDeregulated Nutrient SensingWe sought to characterize metabolic alterations and insulin resistance after burn injury and determine their magnitude and persistence at discharge.26934145
HyperglycemiaDeregulated Nutrient SensingAs hyperglycemia and insulin resistance are associated with poor outcomes, studies should focus on how long these profound alterations persist.26934145
Burn Specimen Source Codes, Glucose Intolerance (disease)Deregulated Nutrient SensingOur findings demonstrated that two-thirds of burn patients had some degree of glucose intolerance.26934145
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHowever, we cannot exclude the possibility that a higher PWV in pSS patients is caused, not by pSS itself, but by the use of steroids, hypertension and dyslipidemia.26935363
Electrocardiogram: myocardial infarction (finding)Deregulated Nutrient SensingFunctionally relevant mutations in the dyslipidemia-related genes and enzymes involved in the reverse cholesterol transport system are associated with CAD and contribute to increased susceptibility of myocardial infarction (MI).26936456
Fibromyalgia, ImpairedDeregulated Nutrient SensingTorque and muscle activation impairment along with insulin resistance are associated with falls in women with fibromyalgia.26937773
Intervertebral Disc DegenerationDeregulated Nutrient SensingSIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway.26940203
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNitrates users had more frequently diabetes, dyslipidemia, and higher body mass index but were less frequently treated with statins.26940569
Osage languageDeregulated Nutrient SensingInsulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA ( P < .001).26941371
Sleep Apnea, Obstructive, Dyslipidemias, Osage languageDeregulated Nutrient SensingObstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk.26941371
melanomaDeregulated Nutrient SensingWe have found that pharmacologic stimulation of the Kv11.3 channel with a small molecule activator, NS1643 induced autophagy via activation of an AMPK-dependent signaling pathway in melanoma cell line.26942884
Behavior, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingChronic kidney disease (CKD) is associated with aging, diabetes, hypertension, dyslipidemia, obesity, and unhealthy lifestyle behaviors and has become a public health burden worldwide.26943182
Breast CarcinomaDeregulated Nutrient SensingAssociation Between Insulin Resistance and Luminal B Subtype Breast Cancer in Postmenopausal Women.26945364
Breast CarcinomaDeregulated Nutrient SensingCurrently, there is limited information on the clinical characteristics of breast cancer patients with insulin resistance.26945364
Breast Carcinoma, Diabetes MellitusDeregulated Nutrient SensingHence, the purpose of this study was to investigate the association between insulin resistance and clinicopathological factors in newly diagnosed breast cancer patients without diabetes.26945364
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingAge, menopausal status, body mass index, tumor size, histologic grade, Ki-67 expression, and breast cancer subtype significantly differed according to the presence of insulin resistance.26945364
ObesityDeregulated Nutrient SensingMultivariate analysis revealed that postmenopausal status and obesity were significantly associated with insulin resistance.26945364
Neoplasms, ObesityDeregulated Nutrient SensingIn postmenopausal women, older age, obesity, larger tumor size, advanced stage, and high proliferative luminal B subtype were significantly associated with insulin resistance.26945364
ObesityDeregulated Nutrient SensingIn contrast, in premenopausal patients, only obesity was related to insulin resistance.26945364
Neoplasms, ObesityDeregulated Nutrient SensingMultivariate analysis indicated that insulin resistance was independently correlated with obesity, larger tumor size, and the luminal B/human epidermal growth factor receptor-2-negative subtype in postmenopausal but not premenopausal patients.26945364
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingInsulin resistance was significantly associated with larger tumors and proliferative luminal B subtype breast cancer in postmenopausal women only.26945364
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingThese findings suggest that insulin resistance could mechanistically induce tumor progression and might be a good prognostic factor, and that it could represent a therapeutic target in postmenopausal patients with breast cancer.26945364
Hyperglycemia, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThis study suggested that obesity may be causally associated with PAD after controlling for the potential intermediate factors like hypertension, dyslipidemia and hyperglycemia.26945778
DeliriumDeregulated Nutrient SensingAltogether, these results suggest that delirium rats induced by scopolamine may be correlated with an increased cerebral concentration of 5-HT and dopamine neurotransmitters system; the selective 5-HT(1A) antagoniszts can reverse the delirium symptoms at some extent through tendering PI3K/Akt/mammalian target of rapamycin complex 1 (mTOR) activation-induced NLRP3 activity and then reducing IL-1b release.26946964
Renal Insufficiency, Hypertension, CTCAE, Metabolic Syndrome XDeregulated Nutrient SensingIncreased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome.26947600
TG gene, DyslipidemiasDeregulated Nutrient SensingDyslipidemia prevalence were as follows: increased TC 7.8%, increased LDL 6.1%, increased TG 0-9years 22.1%, increased TG 10-16years 11.7%, and decreased HDL 8.0%.26948098
AcromegalyDeregulated Nutrient SensingLow insulin resistance after surgery predicts poor GH suppression one year after complete resection for acromegaly: a retrospective study.26949262
Renal Cell Carcinoma PathwayDeregulated Nutrient SensingTo the best of our knowledge, this study is the first to compare dual inhibition of PI3K/mammalian target of rapamycin (mTOR) by apitolisib (GDC-0980) against single inhibition of mTORC1 by everolimus in metastatic renal cell carcinoma (mRCC).26951309
Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingAltered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery.26952538
osteoclast activating factorDeregulated Nutrient SensingThe expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF.26952538
osteoclast activating factorDeregulated Nutrient SensingSo far, information is lacking about the relationship between SIRT1 regulating micro RNAs (miRs), SIRT1 protein and the occurrence of POAF.26952538
osteoclast activating factorDeregulated Nutrient SensingAltered expression of the SIRT1 protein regulating miR-199a in human atrial tissue was found to be related to the occurrence of POAF, indicating its usefulness as a biomarker for cardiac surgery management.26952538
vascular inflammations, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk.26954484
vascular inflammations, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study tested the hypothesis that AGE may improve endothelial function, oxidative stress, vascular inflammation and insulin resistance in high risk cardiovascular subjects with type 2 diabetes.26954484
vascular inflammations, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn this group of type 2 diabetic patients at high cardiovascular risk, 4 weeks treatment with AGE did not significantly improve endothelial function, vascular inflammation, oxidative stress or insulin resistance.26954484
Neuropathy, Dyslipidemias, Diabetes Mellitus, Kidney Diseases, Hypertension, CTCAEDeregulated Nutrient SensingThe factors associated with developing these complications were increasing age, duration of diabetes, hypertension and dyslipidaemia for nephropathy and neuropathy.26958014
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHowever, elderly Chinese with diabetes would have lower cognition function, and the dyslipidemia might be reversely associated with the cognitive function.26959108
diabeticDeregulated Nutrient SensingInsulin Resistance is Associated With Total Bile Acid Level in Type 2 Diabetic and Nondiabetic Population: A Cross-Sectional Study.26962776
Diabetes MellitusDeregulated Nutrient SensingThe increase in the bile acid level in insulin-resistant population regardless of status of diabetes and glucose level indicated the important role of insulin resistance in the regulation of bile acid metabolism in human.26962776
Hepatitis C, ChronicDeregulated Nutrient SensingGC Gene Polymorphism and Unbound Serum Retinol-Binding Protein 4 Are Related to the Risk of Insulin Resistance in Patients With Chronic Hepatitis C: A Prospective Cross-Sectional Study.26962819
Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Chronic liver diseaseDeregulated Nutrient SensingInsulin resistance (IR) is found in chronic hepatitis C (CHC) more frequently than in other chronic liver diseases.Prospective cross-sectional study to evaluate a wide multitest panel to identify factors related with IR in CHC and their possible interactions.In 76 patients with CHC we performed a series of routine laboratory analysis as well as specifically designed serum biochemical tests [retinol, retinol-binding protein 4 (RBP4), 25-OH vitamin D, Vitamin E, lipopolysaccharide-binding protein (LBP), interleukin-6 (IL-6), and cystatin C].26962819
Diabetes MellitusDeregulated Nutrient SensingSubjects with G(120-0) >= 2.50 mmol/L or G30 >= 9.75 mmol/L demonstrated lower degrees of insulin secretion, higher degrees of insulin resistance, and ~6-fold higher risk of developing future diabetes compared to their lower counterparts after adjustment for possible confounding factors.26962830
Dyslipidemias, ObesityDeregulated Nutrient SensingBody Mass Index Is Better than Other Anthropometric Indices for Identifying Dyslipidemia in Chinese Children with Obesity.26963377
Dyslipidemias, ObesityDeregulated Nutrient SensingBMI had better practical utility in identifying dyslipidemia among school-aged children with obesity compared with other anthropometric measures.26963377
Dyslipidemias, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingA cross-sectional study was conducted on 288 patients with dyslipidemia, diabetes, or coronary artery disease on statin therapy.26964726
Diabetes MellitusDeregulated Nutrient SensingTreatment with PDE5i in humans and murine models of diabetes improves VAT, targeting SIRT1 through a modulation of miR-22-3p expression.26964730
Dyslipidemias, Data types - Address, Diabetes Mellitus, Cerebrovascular Disorders, Hypertension, CTCAEDeregulated Nutrient SensingCompared to patients with AD, Dmix patients were older and more likely to present diabetes, hypertension, dyslipidaemia, and history of cerebrovascular disease (P<.05).26971058
Glucose Intolerance (disease), Fatty Liver DiseaseDeregulated Nutrient SensingFatty liver disease is associated with glucose intolerance and hepatic insulin resistance.26971094
Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease, Fatty Liver DiseaseDeregulated Nutrient SensingHowever, there are distinct etiologies for alcoholic versus non-alcoholic fatty liver disease (NAFLD), and it is unknown whether alcohol consumption influences the onset of glucose intolerance in fatty liver disease patients.26971094
Hypertrichosis, Autosomal recessive inheritanceDeregulated Nutrient SensingDonohue syndrome (DS) is a rare and lethal autosomal recessive disease caused by mutations in the insulin receptor (INSR) gene, manifesting marked insulin resistance, severe growth retardation, hypertrichosis, and characteristic dysmorphic features.26974131
Neoplasm Metastasis, Colorectal CarcinomaDeregulated Nutrient SensingSIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression.26975631
Neoplasm MetastasisDeregulated Nutrient SensingIn this study, we explored potential effects of silent mating type information regulation 2 homolog 1 (SIRT1) on CRC metastasis.26975631
Colorectal CarcinomaDeregulated Nutrient SensingOur data showed that ectopic expression of SIRT1 markedly increased the migration and invasion of CRC cells.26975631
Aggressive courseDeregulated Nutrient SensingIn contrast, silencing SIRT1 repressed this behavior in aggressive CRC cells.26975631
NeoplasmsDeregulated Nutrient SensingTumor xenograft experiments revealed that knockdown of SIRT1 impaired CRC metastasis in vivo.26975631
methionine, Colorectal CarcinomaDeregulated Nutrient SensingSilencing SIRT1 in CRC cells induced mesenchymal-epithelial transition (MET), which is the reverse process of epithelial-mesenchymal transition (EMT) and characterized by a gain of epithelial and loss of mesenchymal markers.26975631
Neoplasm Metastasis, Colorectal CarcinomaDeregulated Nutrient SensingMoreover, SIRT1 expression correlated positively with Fra-1 expression, metastasis and overall survival in patients with CRC.26975631
Neoplasm Metastasis, Colorectal CarcinomaDeregulated Nutrient SensingTaken together, our data provide a novel mechanistic role of SIRT1 in CRC metastasis, suggesting that SIRT1 may serve as a potential therapeutic target for metastatic CRC.26975631
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hyperuricemia, Hypertension, CTCAEDeregulated Nutrient SensingIncreasing age (OR = 1.012; 95% CI:1.010, 1.014), male sex (OR = 1.411; 95% CI:1.318, 1.510), obesity (OR = 1.424; 95% CI:1.345, 1.507), cardiovascular disease (OR = 1.343; 95% CI:1.125, 1.603), diabetes (OR = 1.955; 95% CI:1.751, 2.182), hypertension (OR = 1.481; 95% CI:1.391, 1.577) and hyperuricemia (OR = 2.223; 95% CI:2.060, 2.399) were independent risk factors of dyslipidemia.26978581
Dyslipidemias, CDISC SDTM Lesion Complexity TerminologyDeregulated Nutrient SensingInfluence of pharmacotherapy complexity on compliance with the therapeutic objectives for HIV+ patients on antiretroviral treatment concomitant with therapy for dyslipidemia.26980167
Dyslipidemias, CDISC SDTM Lesion Complexity TerminologyDeregulated Nutrient SensingPharmacotherapeutical complexity represents a key factor in terms of achieving health objectives in HIV+ patients on treatment for dyslipidemia.26980167
Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingSeveral compounds in the choline oxidation pathway are associated with insulin resistance and prevalent diabetes; however, prospective data are scarce.We explored the relationships between systemic and urinary choline-related metabolites and incident type 2 diabetes in an observational prospective study among Norwegian patients.26980210
Dyslipidemias, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingThe magnitude of the healthcare problem of type-2-diabetes increases according to its association with several risk factors for cardiovascular diseases such as obesity and dyslipidemia.26982659
Dyslipidemias, Smoking, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAEDeregulated Nutrient SensingSmoking, diabetes mellitus, hypertension, and dyslipidemia are labelled as conventional risk factors for coronary artery disease.26982666
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension (65%), smoking (57.8%) and dyslipidemia (45.5%) were the most common risk factors.26982666
Metabolic DiseasesDeregulated Nutrient SensingThis study reports an independent inverse relationship between daily chocolate consumption and levels of insulin, HOMA-IR and liver enzymes in adults, suggesting that chocolate consumption may improve liver enzymes and protect against insulin resistance, a well-established risk factor for cardiometabolic disorders.26983749
Metabolic DiseasesDeregulated Nutrient SensingFurther observational prospective research and well-designed randomised-controlled studies are needed to confirm this cross-sectional relationship and to comprehend the role and mechanisms that different types of chocolate may play in insulin resistance and cardiometabolic disorders.26983749
DyslipidemiasDeregulated Nutrient SensingAnti-Retroviral Therapy Increases the Prevalence of Dyslipidemia in South African HIV-Infected Patients.26986065
DyslipidemiasDeregulated Nutrient SensingData on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse.26986065
TG gene, DyslipidemiasDeregulated Nutrient SensingSevere dyslipidaemia, (LDLC> 4.9 mmol/L or TG >5.0 mmol/L) was present in <5% of participants.26986065
NeoplasmsDeregulated Nutrient SensingSeveral members of the sirtuin family (SIRT1-7), which are a highly conserved family of NAD+-dependent enzymes, play an important role in tumor formation.26986234
Lipodystrophy, Complication AspectsDeregulated Nutrient SensingInsulin resistance and metabolic complications are less common than with other lipodystrophy subtypes.26987365
Complication AspectsDeregulated Nutrient SensingShe presented no severe metabolic complications, neither signs of insulin resistance.26987365
acetate-CoA ligase activity, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe area under the receiver-operating characteristic curve for prediction of positive CACS increased from 0.665 when considering only risk factors (dyslipidemia, current smoking, hypertension, diabetes, and age) to 0.719 when adding femoral and carotid plaques (p < 0.001).26988945
Metabolic Diseases, Dental Plaque, Data types - AddressDeregulated Nutrient SensingThe neuritic plaque pathology of AD was associated with metabolic disorders such as insulin resistance and abnormal lipid metabolism, whereas the risk factors for tau pathology remain unclear.26989005
Fibrosis AssessmentDeregulated Nutrient SensingIncreased stages of fibrosis were primarily associated with higher levels of HOMA2-insulin resistance (IR), procollagen type I propeptide (P1NP), lower osteocalcin, albumin-corrected calcium, parathyroid hormone, vitamin D, male sex, and higher age.26989059
Dyslipidemias, AlbuminuriaDeregulated Nutrient SensingIndividuals with higher HbA1c levels were more likely to have albuminuria (OR 3.14, 95% CI 1.26-7.82) and dyslipidaemia (OR 2.37, 95% CI 1.29-4.34) and visited the clinic more often (OR 2.52, 95% CI 1.26-4.99).26989697
Cholesterol to HDL-Cholesterol Ratio MeasurementDeregulated Nutrient SensingPolyphenols from olive oil and thyme modified the lipoprotein subclasses profile and decreased the total LDL particle/total HDL particle (HDL-P), small HDL/large HDL, and HDL-cholesterol/HDL-P ratios, and decreased the lipoprotein insulin resistance index (LP-IR) (p < 0.05).26992050
PancreatitisDeregulated Nutrient SensingInsulin Resistance as a Novel Risk Factor for Post-ERCP Pancreatitis: A Pilot Study.26995780
PancreatitisDeregulated Nutrient SensingThe relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known.26995780
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingObese PCOS patients have a higher risk of elevated insulin resistance and b-cell function than do those with BMI <30.26995881
HypoxiaDeregulated Nutrient SensingFurthermore, leptin counteracted the downmodulation of SIRT1 induced by hypoxia, and persistent high levels of SIRT1 were directly involved in HIF-1a stabilization.26996298
Prostate carcinomaDeregulated Nutrient SensingLeptin signaling axis, including the new proposed intermediate SIRT1, could represent a new diagnostic and therapeutic target in prostate cancer.26996298
Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingWe observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM.26996471
Breast CarcinomaDeregulated Nutrient SensingAssociation between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.26999517
Breast CarcinomaDeregulated Nutrient SensingPrevious studies have explored the association of silent mating-type information regulator 2 homolog 1 (SIRT1) gene expression with prognosis in breast cancer.26999517
Breast CarcinomaDeregulated Nutrient SensingHowever, no studies exist, so far, on the role of SIRT1 gene polymorphism in breast cancer risk or prognosis.26999517
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingBreast cancer patients exhibited elevated serum SIRT1 levels which varied among different tumor grades.26999517
Breast CarcinomaDeregulated Nutrient SensingOur findings reveal that rs3758391 and rs12778366 polymorphisms of SIRT1 gene are associated with breast cancer risk and prognosis in the Egyptian population.26999517
Prediabetes syndromeDeregulated Nutrient SensingWe hypothesized that culinary herbs and spices may decrease insulin resistance (IR) and improve WM in prediabetes.27001275
Glioblastoma Multiforme PathwayDeregulated Nutrient SensingInterestingly, PDK4 regulated AMPK phosphorylation which in turn affected cell viability in CK2 inhibitor treated glioma cells.27001465
Glioblastoma Multiforme PathwayDeregulated Nutrient SensingTaken together, CK2 inhibition in glioma cells drives the PDK4-AMPK axis to affect metabolic profile that has a strong bearing on their survival.27001465
Diabetes Mellitus, Non-Insulin-Dependent, PrehypertensionDeregulated Nutrient SensingMetabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension.27001495
Increased insulin level, Hypertensive (finding)Deregulated Nutrient SensingThe premise of this analysis is that insulin resistance/compensatory hyperinsulinemia is a major predictor of T2DM, and the greater the prevalence of insulin resistance within any population, normotensive or hypertensive, the more likely T2DM will develop.27001495
PrehypertensionDeregulated Nutrient SensingThe hypothesis to be tested is that surrogate estimates of insulin resistance will predict incident T2DM to a significant degree in persons with normal blood pressure or prehypertension.27001495
Increased insulin level, Blood Glucose, Dyslipidemias, PrehypertensionDeregulated Nutrient SensingMetabolic variables associated with insulin resistance (glycemia, insulinemia, and dyslipidemia) predict the development of T2DM in patients with either normal blood pressure or prehypertension.27001495
Malignant NeoplasmsDeregulated Nutrient SensingA first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies.27002938
NeoplasmsDeregulated Nutrient SensingOSI-027 inhibits mTORC1/2 in patients with advanced tumour s in a dose-dependent manner but doses above the tolerable levels in S1 and S3 are required for a sustained biological effect in tumour biopsies.27002938
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidaemia in Poland continues to be high--over 60% of adults have hypercholesterolaemia, and control remains poor.27004543
Dyslipidemias, Myocardial Ischemia, Hepatitis C, Hypertensive (finding), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTwenty six (27%) patients had family history of ischemic heart disease, 51 (53.12%) were smokers, 12 (12.5%) were hypertensive, 4 (4.16%) had type 2 diabetes, 23 (23.9%) had dyslipidemia, and 31 (32.3%) were infected with hepatitis C virus.27005326
Hypertension, CTCAE, Heart failure, DyslipidemiasDeregulated Nutrient SensingThe patients invited to participate had heart failure and/or hypertension and/or dyslipidemia.27007065
Cessation of life, Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingDyslipidemia is the most common factor leading to ischemic heart disease, which is one of the leading causes of death.27007528
Chagas Disease, DyslipidemiasDeregulated Nutrient SensingThe potential influence of atherogenic dyslipidemia on the severity of chronic Chagas heart disease.27008492
Dyslipidemias, Hypertension, CTCAE, Coronary heart diseaseDeregulated Nutrient SensingDyslipidemia, arterial hypertension and coronary heart disease were present in the majority of the patients in both groups.27015235
Hypertension, CTCAE, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingHypertension, dyslipidemia, and coronary artery disease had no effect.27015580
Glucose Intolerance (disease), Diabetes, AutoimmuneDeregulated Nutrient SensingIn 2013, she was diagnosed with glucose intolerance and subsequently with latent autoimmune diabetes of adulthood.27017730
Hyperprolactinemia, DIAPH2 gene, Prostate Cancer Outcomes Study, Ovarian Failure, Premature, Polycystic Ovary SyndromeDeregulated Nutrient SensingThere were no significant differences in the prevalence of polycystic ovary syndrome (PCOS), hyperprolactinemia, or premature ovarian failure (POF) between the non-obese women with and without insulin resistance.27018331
InflammationDeregulated Nutrient SensingSerum androgens and inflammation might not contribute to insulin resistance in these women.27018331
Diabetes MellitusDeregulated Nutrient SensingA number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus.27020448
Psoriasis, Chronic inflammatory disorder, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingPsoriasis is a chronic inflammatory disease that has been associated with an increased incidence of insulin resistance and diabetes mellitus (DM).27023086
PsoriasisDeregulated Nutrient SensingThis study confirms a beneficial effect of anti-TNF-a agents on insulin resistance and insulin sensitivity in psoriasis patients with type 2 DM.27023086
Ventricular FibrillationDeregulated Nutrient SensingWomen with lower circulating TSH had higher risk of having a VF, independently of age, menopausal age, and insulin resistance.27023333
Dilated Cardiomyopathy Pathway, Diabetes MellitusDeregulated Nutrient SensingEfficacy of CD34+ Stem Cell Therapy in Nonischemic Dilated Cardiomyopathy Is Absent in Patients With Diabetes but Preserved in Patients With Insulin Resistance.27025690
Doctor of Chiropractic, Dilated Cardiomyopathy Pathway, Diabetes MellitusDeregulated Nutrient SensingWe evaluated the association of diabetes and insulin resistance with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM).27025690
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingTwelve patients had diabetes mellitus (DM group), 17 had insulin resistance (IR group), and 16 displayed normal glucose metabolism (no-IR group).27025690
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingResistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: a randomised controlled clinical trial.27028002
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingImprovement of insulin resistance and inflammation is a basic strategy in the management of type 2 diabetes.27028002
InflammationDeregulated Nutrient SensingThere is limited evidence that prebiotics improve insulin resistance and inflammation.27028002
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHowever, the ameliorating effect of resistant dextrin, as a prebiotic, on insulin resistance and inflammation in patients with type 2 diabetes has not been investigated so far.27028002
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTherefore, the present study aimed to examine the effects of resistant dextrin on insulin resistance and inflammation in type 2 diabetic patients.27028002
Inflammation, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn conclusion, resistant dextrin supplementation can modulate inflammation and improve insulin resistance in women with type 2 diabetes.27028002
ObesityDeregulated Nutrient SensingNone of the patients had obesity and/or insulin resistance.27030332
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a known risk factor for cardiovascular disease and is a leading cause of mortality in developed and developing countries.27033172
Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingIn multivariate logistic regression model, increase of age (for females), abdominal obesity, overweight and obesity, hypertension, and diabetes were associated with an increased odd of dyslipidemia.27033172
DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemia in middle-aged urban population in Iran is high, and with increasing age there is an increased risk of dyslipidemia.27033172
Dyslipidemias, Cardiovascular Diseases, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDM was also associated with and family history of dyslipidemia in women, cardiovascular disease in men, and with hypertension, dyslipidemia and family history of diabetes in both sexes.27035920
Weight decreased, Feeding behaviors, ObesityDeregulated Nutrient SensingCan early weight loss, eating behaviors and socioeconomic factors predict successful weight loss at 12- and 24-months in adolescents with obesity and insulin resistance participating in a randomised controlled trial?27036113
Weight decreased, ObesityDeregulated Nutrient SensingThis study aimed to identify predictors of weight loss at 12- and 24-months in adolescents with obesity and clinical features of insulin resistance.27036113
Proteinuria, Toxic effect, Dyslipidemias, Hypertension, CTCAE, FatigueDeregulated Nutrient SensingMost frequent toxicities included fatigue, hypertension, dyslipidemia, and proteinuria.27036973
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBesides hyperglycaemia and insulin resistance, several factors are associated with a higher cardiovascular risk in type 2 diabetes mellitus (T2DM), many of them being closely related to each other owing to common origins or pathways.27037039
AHSG protein, human, Arterial calcificationDeregulated Nutrient SensingFetuin-A is a hepatic secretory protein that both promotes insulin resistance and inhibits arterial calcification.27038419
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFor the major risk factors of diabetes, hypertension, and dyslipidemia, management for most patients is on the basis of well developed and extensive evidence-based diagnostic and therapeutic guidelines.27040095
Diabetes MellitusDeregulated Nutrient SensingHomeostasis model assessment of b-cell function along with homeostasis model assessment of insulin resistance showed increasing trends as onset age increased in recent-onset diabetes (P for trend < 0.001 in both).27042276
diabeticDeregulated Nutrient SensingElderly-onset diabetic patients had higher insulin resistance and relatively preserved b-cell function compared with middle-age-onset patients.27042276
Impaired T cell function, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance, b-cell dysfunction, and ectopic fat deposition have been implicated in the pathogenesis of coronary artery disease (CAD) and type 2 diabetes, which is common in CAD patients.27045985
diabeticDeregulated Nutrient SensingWe firstly found that the levels of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor coactivator 1a (PGC1a), silent mating-type information regulation 2 homolog 3 (Sirt3) and manganese superoxide dismutase (MnSOD) were all decreased in the skeletal muscle of diabetic patients.27049825
diabeticDeregulated Nutrient SensingCelastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1a-SIRT3 signaling pathway.27049825
diabeticDeregulated Nutrient SensingThe findings of our study suggest that the expression of AMPK, PGC1a, Sirt3 and MnSOD are decreased in the skeletal muscle of diabetic patients.27049825
NeoplasmsDeregulated Nutrient SensingCrosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.27050276
OsteosarcomaDeregulated Nutrient SensingCisplatin (CP) activated the IGF-1R/AKT/mTORC1 pathway and stabilized p53 in osteosarcoma (OS) cells.27050276
Primary malignant neoplasmDeregulated Nutrient SensingTogether, the results demonstrate 1) p53 expression determines the effect of IGF-1R inhibition on cancer cell CP response, and 2) crosstalk between the IGF-1R/AKT/mTORC1 pathway and p53 and p27 can reduce cancer cell responsiveness to chemotherapy and may ultimately limit the effectiveness of IGF-1R pathway inhibitors in the clinic.27050276
Inflammation, ObesityDeregulated Nutrient SensingObesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown.27051864
InflammationDeregulated Nutrient SensingOur study may provide a novel mechanism for the development of sterile inflammation in adipose tissue and a potential therapeutic target for insulin resistance.27051864
diabeticDeregulated Nutrient SensingIn conclusion, the findings of the present study indicated that the addition of exogenous 3DG directly contributed to the induction of insulin resistance by impairing insulin signaling in the HepG2 cells, which suggested that 3DG may be involved in worsening of the diabetic condition.27052187
Dyslipidemias, Fatty degenerationDeregulated Nutrient SensingApolipoprotein-B 100 (ApoB-100) is a dyslipidemia marker and steatosis predictor.27054361
DyslipidemiasDeregulated Nutrient SensingIt is well known that reduced glomerular filtration rate (GFR) leads to an increased risk of dyslipidemia, insulin resistance, and cardiovascular mortality.27056725
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingObesity and insulin resistance are both closely associated with type 2 diabetes mellitus (T2DM).27060004
ObesityDeregulated Nutrient SensingIt is, however, not clear whether the role of obesity in the development of T2DM is dependent on insulin resistance.27060004
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingDiabetic patients were more frequently affected by hypertension (p<0.001) and dyslipidemia (p<0.001) and more frequently dialyzed (p=0.010).27060269
DyslipidemiasDeregulated Nutrient SensingBesides, in CAE group the proportion of dyslipidemia was higher than normal subject.27061992
Chronic Lymphocytic Leukemia, Diabetes Mellitus, Insulin resistance syndromeDeregulated Nutrient SensingWe report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma.27062110
Diabetes MellitusDeregulated Nutrient SensingObserved differences in serum BDNF levels, genetic variants, and DNA methylation patterns across different glucose metabolic state suggest that BDNF may be involved in the pathophysiological process of insulin resistance and type 2 diabetes.27062899
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA common PTEN variation is associated with peripheral insulin resistance and subsequent risk of developing T2D.27068875
Glucose Intolerance (disease), Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingImpaired fasting glucose (IFG) and impaired glucose intolerance (IGT) are predictors of cardiovascular disease (CVD).27069111
Colorectal CarcinomaDeregulated Nutrient SensingVO2peak and ghrelin levels increased after 8 weeks aerobic exercise; however, plasma leptin and insulin resistance were not affected by this protocol in male patients with colorectal cancer.27072232
Stomach CarcinomaDeregulated Nutrient SensingPrognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis.27072976
Stomach CarcinomaDeregulated Nutrient SensingMany studies have reported that the expression of silent information regulator 1 (Sirt1) is associated with the clinical features and prognosis of patients with gastric cancer, but the exact function remains controversial.27072976
Stomach CarcinomaDeregulated Nutrient SensingWe conducted this study to illustrate the clinical and prognostic value of Sirt1 in gastric cancer.27072976
Stomach CarcinomaDeregulated Nutrient SensingIt was suggested that the high expression of Sirt1 implies a poor prognosis of gastric cancer patients in a relatively short period (3 years), but not in a long time (>=5 years).27072976
NeoplasmsDeregulated Nutrient SensingThe expression of Sirt1 is also linked with patients' age, T stage, N stage and tumor differentiation.27072976
Inflammation, diabeticDeregulated Nutrient SensingInsulin Resistance in Relation to Lipids and Inflammation in Type-2 Diabetic Patients and Non-Diabetic People.27073920
Inflammation, Dyslipidemias, diabeticDeregulated Nutrient SensingTo translate our experimental findings to clinical practice, we investigated in Chinese type-2 diabetic patients and in Flemish non-diabetic people the independent and joint associations of insulin resistance with markers of dyslipidaemia and inflammation, while looking for consistency between ethnicities and across the spectrum of insulin resistance.27073920
Negative Regulation of Cell CycleDeregulated Nutrient SensingHigh doses of leptin induced cell cycle arrest and senescence in CPCs by activating the p53/p21 pathway and inhibiting the Sirt1 pathway.27077804
Degenerative polyarthritis, Degenerative disorder of cartilageDeregulated Nutrient SensingActivating the leptin pathway induced higher Ob-Rb expression and was significantly correlated with cartilage degeneration (lower levels of Coll-2) and tissue senescence (higher levels of p53/p21 and lower levels of Sirt1) in OA patients, suggesting that leptin-induced CPCs senescence contributes to the development of OA.27077804
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe Relationship between Dyslipidemia and Acute Axonal Function in Type 2 Diabetes Mellitus In Vivo.27078166
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingIn addition, affected individuals have non-neuronal symptoms such as diabetes mellitus or glucose intolerance.27079523
Diabetes MellitusDeregulated Nutrient SensingHigher exposure to certain phthalates is associated with a diabetes and insulin resistance, with sex differences seen.27079661
Alzheimers Disease", Population at RiskDeregulated Nutrient SensingInsulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults.27079723
Cerebrovascular accidentDeregulated Nutrient SensingA Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack.27080156
Tacca leontopetaloides, Ischemic strokeDeregulated Nutrient SensingWe sought to develop an instrument to screen for insulin resistance in nondiabetic patients with recent ischemic stroke or transient ischemic attack (TIA).27080156
Cerebrovascular accidentDeregulated Nutrient SensingOur 2 scoring systems performed well in identifying stroke patients with insulin resistance, but they are probably not sufficiently accurate for high-stake clinical decisions.27080156
physiopathologicalDeregulated Nutrient SensingInsulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women.27080554
Breast CarcinomaDeregulated Nutrient SensingParticularly, expressions of SIRT1 and SIRT4 were found to be significantly down-regulated in breast cancer tissues and SKBR3 breast cancer cells.27080717
Breast Carcinoma, NeoplasmsDeregulated Nutrient SensingIn conclusion, Sirtuin family of genes shows differential expressions in breast cancer tissues and cells and SIRT1 and SIRT4 seem to play key tumor suppressor roles in breast cancer development.27080717
Metastatic hepatocellular carcinomaDeregulated Nutrient SensingSIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1a-mediated mitochondrial biogenesis.27081083
Neoplasms, Malignant NeoplasmsDeregulated Nutrient SensingSIRT1 is a multifaceted NAD+-dependent protein deacetylase known to act as a tumor promoter or suppressor in different cancers.27081083
Neoplasm Metastasis, FAM126A geneDeregulated Nutrient SensingHere, we describe a novel mechanism of SIRT1-induced hepatocellular carcinoma (HCC) metastasis.27081083
Neoplasm Metastasis, Neoplasms, Vascular Invasion Assessment, FAM126A gene, TNM Staging SystemDeregulated Nutrient SensingSIRT1 overexpression was frequently detected in human HCC specimens and was associated with microvascular invasion (P = 0.0039), advanced tumor node metastasis (TNM) stages (P = 0.0016), HCC recurrence (P = 0.021) and poor outcomes (P = 0.039).27081083
Neoplasm MetastasisDeregulated Nutrient SensingLentivirus-mediated knockdown of SIRT1 in MHCC97H cells reduced invasion and metastasis in vitro and in vivo.27081083
FAM126A geneDeregulated Nutrient SensingElevated SIRT1 expression strongly correlated with the upregulation of PGC-1a in HCC specimens, and ectopic expression of SIRT1 increased PGC-1a levels.27081083
Neoplasm MetastasisDeregulated Nutrient SensingIn cell assays and an orthotopic transplantation model, PGC-1a overexpression reversed the inhibitory effects of SIRT1 depletion on invasion and metastasis by enhancing mitochondrial biogenesis.27081083
Neoplasm MetastasisDeregulated Nutrient SensingThese findings reveal the involvement of SIRT1 in HCC metastasis and provide a rationale for exploring therapeutic targets against the SIRT1/PGC-1a axis.27081083
Dyslipoproteinemias, DyslipidemiasDeregulated Nutrient SensingHowever, the exact associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption remain unknown.27082578
Squamous cell carcinoma of esophagus, DyslipidemiasDeregulated Nutrient SensingThe findings of this study investigating factors that could predict the outcome of NAC(R)T suggest that the prevalence of dyslipidemia influences the outcome of NAC(R)T for ESCC.27082598
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn clinical evaluation, plasma sSortilin was detected at significantly higher levels in cardiovascular risk patients with hypertension, dyslipidemia, and/or diabetes without CAD (non-CAD, 18.7 +- 3.3 ng/mL) than in patients with CAD under aspirin therapy (17.1 +- 3.6 ng/mL; p < 0.01) or in healthy controls (16.8 +- 2.9 ng/mL; p < 0.01).27085161
Kidney Failure, Chronic, Dyslipidemias, Hypertension, CTCAE, Congestive heart failureDeregulated Nutrient SensingAfter adjusting for age, gender, race/ethnicity, presence of dyslipidemia, CHF, and hypertension, CAS performed in ESRD patients was associated with higher rates of in-hospital mortality (OR 3.7, 95% CI 1.0-13.9; P = .04) and moderate to severe disability (OR 1.7, 95% CI 1.0-3.3; P = .05).27085817
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingFamilial dyslipidemia, a frequent genetic cause of premature cardiovascular disease, is still underdiagnosed and undertreated.27089599
Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient Sensing(cardiovascular diseases), Allium sativum L. (dyslipidemia), Cuminum cyminum L. (hypertension), Macrotyloma uniflorum Verdc.27090346
Hyperglycemia, Critical IllnessDeregulated Nutrient SensingEffect of vitamin D on stress-induced hyperglycaemia and insulin resistance in critically ill patients.27091752
diabeticDeregulated Nutrient SensingEffects of vitamin D supplementation on the glycaemic indices and insulin resistance in diabetic and non-diabetic patients were studied.27091752
Hyperglycemia, Critical IllnessDeregulated Nutrient SensingIn this study, effects of vitamin D supplementation on stress-induced hyperglycaemia and insulin resistance were evaluated in non-diabetic surgical critically ill patients.27091752
Sleep Apnea SyndromesDeregulated Nutrient SensingSeveral studies have reported the association between sleep apnea syndrome and insulin resistance.27095251
Sleep Apnea Syndromes, OverweightDeregulated Nutrient SensingBeing overweight is known risk factor both for sleep apnea syndrome and insulin resistance.27095251
Prediabetes syndrome, diabeticDeregulated Nutrient SensingHepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study.27095446
diabeticDeregulated Nutrient SensingAdditionally, the postprandial response was evaluated according to basal insulin resistance subgroups in patients non-diabetic and diabetic without pharmacological treatment (N = 642).27095446
TG geneDeregulated Nutrient SensingPatients with liver insulin resistance (liver-IR) showed higher postprandial response of TG compared with those patients with muscle-IR or without any insulin-resistance respectively (p < 0.001).27095446
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent, Insulin ResistanceDeregulated Nutrient SensingThe postprandial response increases progressively according to non-diabetic, prediabetic and type 2 diabetic state and it is higher in patients with liver insulin-resistance.27095446
Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia (48.9% vs. 26.9%), sport lack (46.6% vs. 31.6%), diabetes mellitus (21.3% vs. 16.5%), and atrial fibrillation (18.7% vs. 9.8%) were more prevalent in the urban group, while smoking (26.5% vs. 28.8%), previous stroke (10.1% vs. 16.9%), and transient ischemic attack (20.9% vs. 24.6%) were less prevalent.27096105
Retention (Psychology), Chronic Kidney DiseasesDeregulated Nutrient SensingThe colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.27100399
Chronic Kidney DiseasesDeregulated Nutrient SensingWhether prebiotics can reduce intestinal generation of these microbial metabolites and improve insulin resistance in CKD patients not yet on dialysis remains unknown.27100399
Axos, Retention (Psychology), Chronic Kidney DiseasesDeregulated Nutrient SensingIn conclusion, we could not demonstrate an influence of prebiotic AXOS on microbiota derived uremic retention solutes and insulin resistance in patients with CKD not yet on dialysis.27100399
ObesityDeregulated Nutrient SensingObesity and Insulin Resistance Screening Tools in American Adolescents: National Health and Nutrition Examination Survey (NHANES) 1999 to 2010.27103108
ObesityDeregulated Nutrient SensingTo identify which feasible obesity and insulin resistance (IR) screening tools are most strongly associated in adolescents by using a nationally representative sample.27103108
Asthma, ObesityDeregulated Nutrient SensingInsulin resistance modifies the association between obesity and current asthma in adults.27103388
Asthma, ObesityDeregulated Nutrient SensingThe relationship between obesity and current asthma was stronger with increasing insulin resistance tertiles (OR 2.05, 95% CI 2.76-3.00; p-value for interaction 0.03).27103388
AsthmaDeregulated Nutrient SensingTargeting insulin resistance may represent a novel therapeutic strategy for obese patients with asthma.27103388
diabeticDeregulated Nutrient SensingIn the intergroup comparison, insulin resistance (p = 0.044) and hemoglobin (p = 0.001) were worse in the group that used LHRH analogs, which was mainly diabetic patients (p = 0.007).27103427
Bone Demineralization, Pathologic, Anemia, diabeticDeregulated Nutrient SensingThis study showed that LHRH analogs had worse effects relative to insulin resistance, mainly in diabetic patients, and induced more anemia and bone demineralization compared to surgical castration.27103427
Dyslipidemias, Congestive heart failureDeregulated Nutrient SensingCompared with patients without SVA, patients with new onset SVA were older (69 +- 12 yrs vs 59 +- 13 yrs, P=.003), had congestive heart failure (47% vs 24%, P=.015) and dyslipidemia (41% vs 15%, P=.002).27103771
DyslipidemiasDeregulated Nutrient SensingThis suggests that rare mutations in OSBPL genes may contribute to dyslipidemias.27105157
Carotid Stenosis, DyslipidemiasDeregulated Nutrient SensingAll demographic data were similar between the two groups except for dyslipidemia, which was greater in the BZ group (72% vs 47%, P = .03) and the subocclusive feature of carotid stenosis (14% in the TI group vs 33% in the BZ group, P .04).27109793
Rabson-Mendenhall SyndromeDeregulated Nutrient SensingRabson-Mendenhall syndrome is a rare genetic disorder resulting from mutations in the insulin receptor and is associated with high degrees of insulin resistance.27112737
Uterine Polyp, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe incidence of diabetes, hypertension, and dyslipidemia was higher among women with endometrial polyps (P < 0.0001).27116465
Uterine Polyp, Hyperglycemia, Dyslipidemias, ETV3 wt Allele, ObesityDeregulated Nutrient SensingIn postmenopausal women, obesity, dyslipidemia, hyperglycemia, and the presence of MetS were predictive factors for endometrial polyps.27116465
Lipolysis, Obesity, AtherosclerosisDeregulated Nutrient SensingFatty acid-binding protein 4 (FABP4/A-FABP/aP2) is secreted from adipocytes in association with catecholamine-induced lipolysis, and elevated serum FABP4 level is associated with obesity, insulin resistance and atherosclerosis.27124282
Diabetes MellitusDeregulated Nutrient SensingWhile laboratory studies show that air pollutants can potentiate insulin resistance, the epidemiologic evidence regarding the association of air pollution with diabetes incidence is conflicting.27124624
Angioimmunoblastic Lymphadenopathy, Malignant NeoplasmsDeregulated Nutrient SensingRrecently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma, but has not yet been explored in Angioimmunoblastic T-cell lymphoma (AITL).27124741
Drug Eruptions, Hyperglycemia, Hypertensive (finding), ObesityDeregulated Nutrient SensingWe have diagnosed 81 cases of drug-induced hypertension, and 43 patients with hypertensive crises; 72 cases of iatrogenic hyperglycemia; 36 cases of drug-induced hyperuricemia; 50 cases of drug-induced dyslipidemias; and 17 cases of iatrogenic obesity.27125072
CalculiDeregulated Nutrient SensingCalculated insulin resistance correlates with stone-forming urinary metabolic changes and greater stone burden in high-risk stone patients.27125629
Increased insulin level, Pathogenesis, HypercalciuriaDeregulated Nutrient SensingProposed mechanisms of lithogenesis include insulin resistance causing low urine pH and hyperinsulinemia leading to hypercalciuria.27125629
Pathogenic organismDeregulated Nutrient SensingHerein, we sought to determine whether insulin resistance was associated with differences in stone burden and lithogenic changes on 24-hour urine samples.27125629
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingIn univariate analysis, dyslipidemia, age, coronary artery disease, antiplatelet agents, number of catheters used, urgent settings, and interventional procedures were significantly different.27127790
Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Weight decreased, Hypertension, CTCAEDeregulated Nutrient SensingAfter adjusting for age, BMI, sex, diabetes, hypertension, and dyslipidemia, patients that developed organ cancer achieved less weight loss (-1.5 % TWL, 95 % CI = [-2.9 %, -0.1 %], p = 0.034).27129801
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrediction of insulin resistance in type 2 diabetes mellitus using routinely available clinical parameters.27131406
Polycystic Ovary SyndromeDeregulated Nutrient SensingEffect of metformin by employing 2-hour postload insulin for measuring insulin resistance in Taiwanese women with polycystic ovary syndrome.27131512
ObesityDeregulated Nutrient SensingActivation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications.27133129
ObesityDeregulated Nutrient SensingChronic Activation of g2 AMPK Induces Obesity and Reduces b Cell Function.27133129
ObesityDeregulated Nutrient SensingHere, we observe that mice with chronic AMPK activation, resulting from mutation of the AMPK g2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion.27133129
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk.27134062
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingThe precise associations between stroke and carotid plaques and dyslipidemia are unclear.27134771
Hypomagnesemia, Diabetes MellitusDeregulated Nutrient SensingHypomagnesemia is a frequent finding in kidney transplant patients and plays a causal role in insulin resistance and diabetes.27136250
Obesity, Abdominal, Diabetes MellitusDeregulated Nutrient SensingWe conclude that low fitness, adiposopathy, as well as adiposity (and in particular abdominal obesity) are independent contributors to insulin resistance in men without diabetes.27139423
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingWe included hypertension, dyslipidemia, diabetes, overweight/obesity, smoking, and family history of cardiovascular disease in the count of traditional risk factors (CRFs).27139787
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingLow birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear.27141948
Scleroderma , Infection caused by Helicobacter pyloriDeregulated Nutrient SensingType B insulin resistance syndrome with Scleroderma successfully treated with multiple immune suppressants after eradication of Helicobacter pylori infection: a case report.27142369
Autoimmune DiseasesDeregulated Nutrient SensingType B insulin resistance is a rare autoimmune disease characterized by the presence of autoantibodies against the insulin receptor.27142369
Autoimmune DiseasesDeregulated Nutrient SensingThe present case suggests H pylori infection-related pathological mechanism may contribute to type B insulin resistance syndrome and autoimmune disorders.27142369
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThey help patients achieve disease-state goals for diabetes, hypertension, and dyslipidemia through a variety of clinical interventions and by promoting medication adherence.27143351
Obesity, Diabetes MellitusDeregulated Nutrient SensingInhibition of CTRP5 action may result in the alleviation of insulin resistance associated with obesity and diabetes.27143553
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGlucose intolerance (insulin resistance) is the main feature of type 2 diabetes.27143868
Breast Carcinoma, NeoplasmsDeregulated Nutrient Sensingmir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK.27145268
Breast Carcinoma, Malignant NeoplasmsDeregulated Nutrient SensingRecently, AMPK dysfunction has been highlighted in cancers, including breast cancer.27145268
Breast CarcinomaDeregulated Nutrient SensingThe aim of this study is to investigate the biological roles of mir-101-3p and AMPK in breast cancer.27145268
Breast CarcinomaDeregulated Nutrient SensingOur research demonstrated that AMPK was up-regulated in breast cancer tissues and cell lines, especially in triple negative breast cancer (TNBC).27145268
Breast CarcinomaDeregulated Nutrient SensingHigh-expression of AMPK correlated with poor outcome in both total breast cancer and TNBC patients.27145268
NeoplasmsDeregulated Nutrient SensingOur study provides evidence that mir-101-3p- AMPK axis could be a promising therapeutic target in TNBC targeting tumor metabolism.27145268
Neoplasm Metastasis, Colorectal CarcinomaDeregulated Nutrient SensingDownregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling.27145368
Colorectal CarcinomaDeregulated Nutrient SensingFurther dual-luciferase reporter gene assays revealed that SIRT1 was the direct target of miR-199b in CRC.27145368
Colorectal CarcinomaDeregulated Nutrient SensingThe expression of miR-199b was inversely correlated with SIRT1 in CRC specimens.27145368
Neoplasm MetastasisDeregulated Nutrient SensingFurthermore, through Human Tumor Metastasis PCR Array we discovered KISS1 was one of the downstream targets of SIRT1.27145368
Colorectal CarcinomaDeregulated Nutrient SensingThus, we concluded that miR-199b regulates SIRT1/CREB/KISS1 signaling pathway and might serve as a prognosis marker or a novel therapeutic target for patients with CRC.27145368
Hypertension, CTCAE, Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingHypertension and dyslipidaemia were the most common cardiovascular comorbidities, present in 2920 (51.0%) and 2664 patients (46.6%) respectively.27146460
Apolipoproteins, Postmenopausal state, Obesity, AbdominalDeregulated Nutrient SensingPostmenopausal hypertension, abdominal obesity, apolipoprotein and insulin resistance.27149156
diabeticDeregulated Nutrient SensingImpact of Physical Activity on Glycemic Control and Insulin Resistance: A Study of Community-dwelling Diabetic Patients in Eastern China.27150854
Dyslipidemias, Atrial Fibrillation by ECG Finding, Cerebrovascular accidentDeregulated Nutrient SensingThe post-intervention group had higher rates of dyslipidemia and minor stroke [defined as National Institutes of Health Stroke Scale (NIHSS) <= 3]; less frequent atrial fibrillation; higher numbers of current smokers, heavy drinkers, referrals, and multi-model head imaging cases; and lower NIHSS scores and blood sugar level (all P < 0.05).27152854
HD Term TypeDeregulated Nutrient SensingLinear and stepwise multivariable adjustment analyses revealed that insulin resistance and the o-6/o-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients.27157471
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingAs a low-pigment skin type is prevalent in men and women with type 1 diabetes, it is possible that skin pigmentation may be associated with insulin resistance.27161346
Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cardiovascular DiseasesDeregulated Nutrient SensingSecondary variables: gender, atrial fibrillation, diabetes mellitus, dyslipidemia, cardiovascular disease, age and the physician having attended a cardiovascular training course (ESCARVAL).27163781
Congenital Generalized Lipodystrophy Type 1, No metabolic abnormalitiesDeregulated Nutrient SensingOur data indicate that patients with congenital generalized lipodystrophy type 4 should be meticulously evaluated for cardiac, neuromuscular, gastrointestinal and skeletal diseases, as well as metabolic abnormalities associated with insulin resistance.27167729
Inflammation, Non-alcoholic Fatty Liver Disease, Prediabetes syndromeDeregulated Nutrient SensingSubclinical inflammation in relation to insulin resistance in prediabetic subjects with nonalcoholic fatty liver disease.27169860
Inflammation, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHowever, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state.27169860
Inflammation, Non-alcoholic Fatty Liver Disease, Prediabetes syndromeDeregulated Nutrient SensingSubclinical chronic inflammation and insulin resistance seem to be independent mediators of the association between NAFLD and prediabetes.27169860
Dyslipidemias, Prediabetes syndromeDeregulated Nutrient SensingThe data also indicate that the inflammatory condition and insulin resistance are associated with each other and these, in turn, are affected by adiposity and dyslipidemia in prediabetic subjects.27169860
Cortical malformations, EpilepsyDeregulated Nutrient SensingGATOR1 complex gene mutations leading to mTORC1 pathway upregulation is an important cause of focal epilepsy with cortical malformations and represents a potential target for novel therapeutic approaches.27173016
PancreatitisDeregulated Nutrient SensingIncreased insulin resistance and reduced insulin clearance may be important components of hyperinsulinemic compensation in patients after acute pancreatitis.27173509
InflammationDeregulated Nutrient SensingOur data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents.27174144
Chronic Kidney Insufficiency, Dyslipidemias, Coronary heart disease, Peripheral Vascular Diseases, Tobacco, Cardiovascular systemDeregulated Nutrient SensingThe patients of group 2 had significantly more risk factors and cardiovascular comorbidities (coronary disease, tobacco addiction, dyslipidemia, peripheral arterial disease, chronic renal insufficiency).27174351
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingOral administration of nicotinamide riboside, a natural NAD(+) precursor, completely corrected these NAFLD phenotypes induced by NAD(+) deficiency alone or HFD, whereas adenovirus-mediated SIRT1 overexpression only partially rescued these phenotypes.27174364
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIndependent predictors of low-density lipoprotein cholesterol < 70 mg/dL were diabetes mellitus, wholegrain bread, shorter history of dyslipidemia, and, especially, high-intensity cholesterol-lowering therapies.27178117
Fanconi AnemiaDeregulated Nutrient SensingEndocrinopathies, Bone Health, and Insulin Resistance in Patients with Fanconi Anemia after Hematopoietic Cell Transplantation.27180116
Diabetes Mellitus, Non-Insulin-Dependent, DiseaseDeregulated Nutrient SensingObesity-associated insulin resistance in type 2 diabetes is a disorder in the balance between pro-inflammatory and anti-inflammatory signals.27182056
Inflammation, OverweightDeregulated Nutrient SensingResting Heart Rate Variability, Inflammation, and Insulin Resistance in Overweight and Obese Adolescents.27182718
Inflammation, Autonomic nervous system disordersDeregulated Nutrient SensingChronic low-grade inflammation, insulin resistance, and autonomic dysfunction are present at an early age in obese youths; early detection of inflammation may facilitate meaningful lifestyle changes in this high-risk group.27182718
Diabetes MellitusDeregulated Nutrient SensingInsulin Resistance and Diabetes Mellitus in Contemporary Cardiac Rehabilitation.27182762
Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe goal of this study was to determine the prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) in contemporary cardiac rehabilitation (CR) and to compare clinical responses in CR between these subsets of patients with coronary heart disease (CHD).27182762
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingPrior studies conducted in Greece consistently indicate that dyslipidemia is suboptimally managed, while the burden of cardiovascular disease (CVD) and related risk factors is rising.27183455
Chronicity, DyslipidemiasDeregulated Nutrient SensingIndependent risk factors for chronicity were older age [OR: 1.06, p=0.011], dyslipidemia [OR: 4.26, p=0.04] and severe DILI [OR: 14.22, p=0.005].27184533
DyslipidemiasDeregulated Nutrient SensingOne year is the best cut-off point to define chronic DILI or prolonged recovery, with risk factors being older age, dyslipidemia and severity of the acute episode.27184533
Chronicity, DyslipidemiasDeregulated Nutrient SensingRisk factors for DILI chronicity are older age, dyslipidemia and severity of the acute episode.27184533
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingCirculating serum FGF19 concentrations were decreased (P < 0.01) similarly in obese patients regardless of their degree of insulin resistance, while FGF21 levels were increased in obesity (P < 0.01), being further increased in obesity-associated T2D (P < 0.01).27188262
SteatohepatitisDeregulated Nutrient SensingIncreased hepatic steatosis was significantly associated with the presence of T2DM, and insulin resistance induced by hepatic fat may be an important mechanistic connection.27189281
ObesityDeregulated Nutrient SensingAssociation of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population.27189377
ObesityDeregulated Nutrient SensingConfirmatory associations were also observed between leptin and obesity, blood lipids and insulin resistance for the first time in an African population.27189377
ObesityDeregulated Nutrient SensingGender was significant covariate interacting with insulin sensitivity/insulin resistance and obesity indexes associations in this population.27189377
Inflammation, Dyslipidemias, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingDiabetes, dyslipidaemia, inflammation and mineral-bone disorders play a role in the appearance of PAD in CKD.27190385
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdd-on treatment with intermediate-acting insulin versus sliding-scale insulin for patients with type 2 diabetes or insulin resistance during cyclic glucocorticoid-containing antineoplastic chemotherapy: a randomized crossover study.27191794
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingDiagnosis of hypertension at follow-up among subjects normotensive at baseline was independently associated with obesity at baseline (relative risk (RR) = 1.40 [1.12-1.75] for BMI between 27 and 30 kg/m2 and 1.72 [1.33-2.25] for BMI >=30 kg/m2 as compared with BMI <27 kg/m2) and HbA1C (RR =1.12 [1.05-1.19] per %), suggesting a prominent role of insulin resistance in our population.27195533
Cardiovascular DiseasesDeregulated Nutrient SensingThese findings suggest a CD34+/VEGFR2+ EPC mobilization defect in IGT and T2DM that could play a role in the cardiovascular diseases and capillary rarefaction associated with insulin resistance.27197857
InflammationDeregulated Nutrient SensingCorrelation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population.27199507
InflammationDeregulated Nutrient SensingThe findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.27199507
Benign Paroxysmal Positional VertigoDeregulated Nutrient SensingIn this study, we report that the miR-34a and Sirtuin 1 (SIRT1) genes correlated with the treatment effects of CRP in BPPV subjects.27203679
Benign Paroxysmal Positional VertigoDeregulated Nutrient SensingWe found that miR-34a expression was largely inhibited and SIRT1 expression was significantly reversed after BPPV maneuver treatment.27203679
Benign Paroxysmal Positional VertigoDeregulated Nutrient SensingWe conclude that BPPV treatment might involve some epigenetic regulations through the mediation of miR-34a, SIRT1 functions and repression of redox status.27203679
Dyslipidemias, TransaminasesDeregulated Nutrient SensingRelation between Liver Transaminases and Dyslipidaemia among 2-10 y.o.27203747
Liver damage, Overweight, DyslipidemiasDeregulated Nutrient SensingThe increase in overweight and obese children may be linked to increased rates of liver damage and dyslipidaemia.27203747
DyslipidemiasDeregulated Nutrient SensingThis study aimed to explore the associations of liver biomarkers with overweight/obesity and dyslipidaemia in Mexican children.27203747
TG gene, DyslipidemiasDeregulated Nutrient SensingChildren with high ALT (defined as >=P75) showed higher prevalence of dyslipidaemia than their counterparts, with high prevalence of high TChol (P = 0.053), non-HDL-chol, TG, and low HDL-chol.27203747
Dyslipidemias, Myocardial Ischemia, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingAdditionally they were more likely to have history of ischemic heart disease, diabetes, dyslipidemia, and less likely to have chronic kidney disease (p < 0.001 for all comparisons).27206336
Glucose Intolerance (disease), PolyneuropathyDeregulated Nutrient SensingAlthough the reduction of IENFD becomes evident as polyneuropathy becomes severe, the effects of glucose intolerance should also be considered in patients with moderate to severe reductions.27206908
Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingDyslipidemia is a pivotal risk factor for coronary heart disease (CHD).27206944
DyslipidemiasDeregulated Nutrient SensingThe purpose of this study was to identify the profile of dyslipidemia in a Brazilian population, according to high low-density lipoprotein (LDL-C) levels.27206944
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe recently discovered the presence of multiple Toll-like receptor 4 (TLR4) signaling intermediates in leukocytes from patients with type 2 diabetes or acute insulin resistance associated with cardiopulmonary bypass surgery.27207509
Overweight, Cardiovascular DiseasesDeregulated Nutrient SensingRisk of insulin resistance, impaired glycemic control, and cardiovascular disease is excessive in overweight and obese populations.27207552
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes (T2D) is a heterogeneous disorder with contributions from peripheral insulin resistance and b-cell dysfunction.27207554
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA protective effect could possibly be masked by a smoking-induced aggravation of insulin resistance, akin to the diabetogenic effect seen in individuals with type 2 diabetes.27208379
DyslipidemiasDeregulated Nutrient SensingTherefore, glucose fluctuations may be an important target for secondary prevention after coronary stenting, which is independent of dyslipidemia control.27208906
Hepatobiliary Disorder, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD), a main liver disease around the world, is closely associated with insulin resistance, type 2 diabetes mellitus (T2DM) and other metabolic diseases.27211699
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingAspartame intake is associated with greater glucose intolerance in individuals with obesity.27216413
Pulmonary HypertensionDeregulated Nutrient SensingProtective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice.27217398
Pulmonary arterial hypertension, Polycyclic Hydrocarbons, AromaticDeregulated Nutrient SensingHowever, the role of endothelial AMPK in the pathogenesis of pulmonary arterial hypertension (PAH) remains to be elucidated.27217398
Hypoxia, Pulmonary HypertensionDeregulated Nutrient SensingImmunostaining showed that endothelial AMPK is downregulated in the pulmonary arteries of patients with PAH and hypoxia mouse model of pulmonary hypertension (PH).27217398
HypoxiaDeregulated Nutrient SensingTo elucidate the role of endothelial AMPK in PH, we used endothelial-specific AMPK-knockout mice (eAMPK(-/-)), which were exposed to hypoxia.27217398
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingA novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes.27221093
Non-alcoholic Fatty Liver Disease, Diabetes MellitusDeregulated Nutrient SensingHepatocyte-derived fibrinogen-related protein 1 (HFREP1) is a hepatokine that mediates NAFLD development; however, the role of HFREP1 in the development of insulin resistance and diabetes remains obscure.27221093
Diabetes MellitusDeregulated Nutrient SensingThese findings highlight the crucial role of HFREP1 in insulin resistance and diabetes, and provide a potential strategy and biomarker for developing therapeutic approaches to combat these diseases.27221093
Heart failureDeregulated Nutrient SensingStatin treatment is associated with a negative correlation between NT-proBNP and insulin resistance in patients without history of heart failure.27221204
Inflammation, muscle massDeregulated Nutrient SensingOur results suggested that major contributing factors to PEW were reduced muscle mass, unintentional low dietary energy intake, lower amount of exercise, insulin resistance, and chronic inflammation.27222412
DyslipidemiasDeregulated Nutrient SensingRJ supplementation may offer an alternative method of controlling the menopause - associated dyslipidemia.27227757
Sleep Apnea, Obstructive, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingObstructive sleep apnea combined dyslipidemia render additive effect on increasing atherosclerotic cardiovascular diseases prevalence.27228976
Osage language, Sleep Apnea, Obstructive, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingCurrent study was designed to investigate the effects of obstructive sleep apnea (OSA) combined dyslipidemia on the prevalence of atherosclerotic cardiovascular diseases (ASCVD).27228976
Dyslipidemias, Osage languageDeregulated Nutrient SensingThis was a cross-sectional study and subjects with documented dyslipidemia and without previous diagnosis of OSA were enrolled.27228976
Osage language, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingLogistic regression analysis revealed that in unadjusted model, compared to dyslipidemia plus no-OSA group (reference group), OSA enhanced ASCVD risk in subjects with dyslipidemia, regardless of OSA severity.27228976
Dyslipidemias, Osage languageDeregulated Nutrient SensingOSA combined dyslipidemia conferred additive adverse effects on cardiovascular system, with severe-OSA most prominent.27228976
Vascular System InjuriesDeregulated Nutrient SensingThe association between PWV and the loss of dipping and insulin resistance levels, independently of the BMI, reinforces the contribution of these comorbidities to vascular injury in early life.27232909
Dilated Cardiomyopathy PathwayDeregulated Nutrient SensingDe novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy.27234373
Heart failure, SyndromeDeregulated Nutrient SensingThese findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes.27234373
Carotid AtherosclerosisDeregulated Nutrient SensingThe triglyceride/HDL cholesterol ratio, as a surrogate marker of insulin resistance, may be associated to presence of subclinical carotid atherosclerosis in postmenopausal women.27236636
Dental PlaqueDeregulated Nutrient SensingIn postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque.27236636
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingHowever, gender (OR = 1.475, p < 0.001), aging (OR = 1.283, p < 0.001), dyslipidemia (OR = 1.544, 95%CI: 1.315, 1.814, p < 0.001) and hyperglycemia (OR = 1.247, 95%CI: 1.068, 1.455, p = 0.005) was associated with increased risk of mild reduced eGFR.27240390
Fibrosis AssessmentDeregulated Nutrient SensingPredictors of non-response were high BMI, insulin resistance, significant fibrosis and inadequate compliance.27241647
Dyslipidemias, Obesity, AtherosclerosisDeregulated Nutrient SensingElevated serum FABP4 level is associated with obesity, insulin resistance, dyslipidemia, and atherosclerosis.27241838
DyslipidemiasDeregulated Nutrient SensingCirculating FABP4 is independently associated with the PCSK9 level, suggesting that elevation of FABP4 level as an adipokine leads to dyslipidemia through increased PCSK9 level and subsequent degradation of the LDL receptor.27241838
Glucose Intolerance (disease)Deregulated Nutrient SensingThe mean GA/HbA1c ratio was 2.81+-0.38, and it significantly increased with the presence of glucose intolerance (all, P<0.05).27242118
Autoimmune Thyroid Disease PathwayDeregulated Nutrient SensingAssociation between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease.27245255
Autoimmune DiseasesDeregulated Nutrient SensingSirtuin1 (SIRT1) is a Class 3 nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) that is thought to be implicated in the protection against autoimmune diseases.27245255
Autoimmune Thyroid Disease Pathway, Vitamin D measurementDeregulated Nutrient SensingHowever, an association between SIRT1 and autoimmune thyroid disease (AITD) has not been reported.27245255
HD Term TypeDeregulated Nutrient SensingWe also measured the levels of SIRT1 mRNA in CD4(+) T cells from 18 control subjects, 16 patients with GD in remission and 14 patients with mild HD using a real-time PCR method.27245255
NeoplasmsDeregulated Nutrient SensingOur results propose that HSP60 silencing disrupts the integrity of the respiratory complex I and triggers the excessive ROS production, which promotes tumor progression in the following aspects: (1) ROS activates the AMPK pathway that promotes acquisition of the Warburg phenotype in HSP60-KN cells; (2) ROS generated by HSP60 knockdown or by rotenone inhibition drives cells to undergo EMT; and (3) the high level of ROS may also fragment the Fe-S clusters that up regulates ADHFe1 expression and the 2-hydroxygluterate (2-HG) production leading to changes in DNA methylation.27246978
Degenerative polyarthritisDeregulated Nutrient SensingMicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis.27247228
Degenerative polyarthritisDeregulated Nutrient SensingThe results suggest that miR-34a has a crucial role in the pathogenesis of OA through direct regulation of the SIRT1/p53 signaling pathway and serves as a potential therapeutic target of OA.27247228
Cataract, Arthritis, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension, arthritis, and dyslipidemia were associated with cataract surgery at least in one of these LRAs.27247507
Presenile dementia, Demographics DomainDeregulated Nutrient SensingInsulin resistance is considered to play an important role in the associations between DM and dementia.27250528
DamageDeregulated Nutrient SensingEvolution of target organ damage and haemodynamic parameters over 4 years in patients with increased insulin resistance: the LOD-DIABETES prospective observational study.27251684
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingHowever, the effect of dyslipidemia on acute ischemic stroke is unclear.27256172
Dyslipidemias, Progressive neurologic deterioration, Ischemic stroke, Endoglin, humanDeregulated Nutrient SensingWe hypothesized that dyslipidemia could contribute to early neurological deterioration (END) after ischemic stroke.27256172
Proteinuria, Gout, Dyslipidemias, Congestive heart failure, Acute Kidney Injury, CTCAE, Coronary Artery DiseaseDeregulated Nutrient SensingData regarding various predictors such as age, sex, race, proteinuria, medication use, contrast exposure, acute kidney injury episodes, coronary artery disease, congestive heart failure, dyslipidemia, gout etc.27257659
Dyslipidemias, Coronary Artery DiseaseDeregulated Nutrient SensingDistinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India.27257688
Dyslipidemias, Obesity, Coronary heart diseaseDeregulated Nutrient SensingWhile the prevalence of chronic ischemic coronary disease, dyslipidemia, smokers and obesity, was lower.27257851
Weight decreasedDeregulated Nutrient SensingThe specific type of BS is a determinant of monocyte count variation independent of the amount of weight loss or the degree of insulin resistance improvement.27260650
Normokalemic Periodic Paralysis, Glucose Intolerance (disease)Deregulated Nutrient SensingWe aimed to investigate the effects of potassium supplementation and alkali supplementation in non-acidotic, normokalemic humans with combined glucose intolerance.27260862
Glucose Intolerance (disease), Ovarian failureDeregulated Nutrient SensingGlucose intolerance and compensatory pancreatic b-cell mass caused by GC were not modified by ovarian failure in the VCD+DEX group.27264932
Lipodystrophy, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHIV patients on highly-active antiretroviral therapy (HAART) have shown elevated incidence of dyslipidemia, lipodystrophy, and markers of cardiovascular disease.27270208
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingMild subclinical hypothyroidism (SCH) affects a large number of people and is known to be a risk factor for dyslipidemia.27270263
TG gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine the effects of volanesorsen (ISIS 304801), a second-generation 2'-O-methoxyethyl chimeric antisense inhibitor of apolipoprotein (apo)C-III, on triglyceride (TG) levels and insulin resistance in patients with type 2 diabetes.27271183
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAntisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes.27271183
Alteration, HyperglycemiaDeregulated Nutrient SensingThis coupled with the evidence of a strong inverse association with glycaemic indices and insulin resistance postulates the role of mineral alterations in the pathophysiology of hyperglycaemia and insulin resistance.27272715
Glucose Intolerance (disease), Pancreatic carcinoma, Diabetes MellitusDeregulated Nutrient SensingLong-standing diabetes or glucose intolerance is recognized as a crucial event in the process of pancreatic cancer.27276680
Hyperglycemia, diabeticDeregulated Nutrient SensingEffects of Long-Term Alpha-mangostin Supplementation on Hyperglycemia and Insulin Resistance in Type 2 Diabetic Rats Induced by High Fat Diet and Low Dose Streptozotocin.27276829
Dyslipidemias, Diabetes Mellitus, Retinal Diseases, Peripheral Vascular Diseases, Peripheral NeuropathyDeregulated Nutrient SensingThe associated risk factors were the presence of diabetes (OR 1.67 [1.49-1.88] p < 0.001), history of foot ulceration (OR 81 [18.20-360.48] p < 0.001), peripheral arterial disease (OR 31.29 [9.02-108.56] p < 0.001), peripheral neuropathy (OR 31.29 [9.02-108.56] p < 0.001), foot deformity (OR 23.62 [5.82-95.93] p < 0.001), retinopathy (OR 6.08 [2.64-14.02] p < 0.001), dyslipidemia (OR 4.6 [1.05-20.05] p= 0.049) and indigenous background (OR 3.39 [1.38-8.33] p= 0.01).27277135
Abnormal renal function, Disorder of macula due to diabetes mellitus, Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingIt is evident that diabetic maculopathy has association with dyslipidaemia, abnormal renal function due to nephropathy.27277354
Breast CarcinomaDeregulated Nutrient SensingImmunohistochemical expressions of FOXM1, FOXO3a, SIRT1 and SIRT6 were evaluated in tissue microarray blocks containing 688 consecutive breast cancer samples.27277416
Triple-Negative Breast Cancer FindingDeregulated Nutrient SensingHigh expression of FOXM1 was significantly correlated with high SIRT1 and SIRT6 expression, higher histologic grade and triple-negative breast cancer (TNBC).27277416
Hepatitis BDeregulated Nutrient SensingInsulin resistance increases loss of antibody to hepatitis B surface antigen in nondiabetic healthy adults.27279074
Impaired T cell functionDeregulated Nutrient SensingStandard laboratory tests were conducted for insulin resistance and b-cell dysfunction.27281097
AneurysmDeregulated Nutrient SensingIn the aorta of smooth muscle cell-specific sirtuin-1-deficient mice, spontaneous aneurysm formation and senescence are observed.27283746
Cessation of life, Dyslipidemias, Carcinoma of lungDeregulated Nutrient SensingLong-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death.27283991
Diabetes MellitusDeregulated Nutrient SensingGlucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria.27285104
Gestational Diabetes, Glucose Intolerance (disease), Beta-Cell Function MeasurementDeregulated Nutrient SensingGlucose intolerance is very frequent in early postpartum in women with GDM based on the 2013 WHO criteria in a two-step screening strategy and these women have an impaired beta-cell function.27285104
Refractory Cytopenia of Childhood, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingAllosteric inhibitors of the mammalian target of rapamycin complex 1 (mTORC1) are approved for advanced renal cell carcinoma (RCC).27286790
ObesityDeregulated Nutrient SensingThis finding was independent of obesity and insulin resistance.27304050
FAI - Free androgen index measurementDeregulated Nutrient SensingInsulin resistance (IR) and free androgen index (FAI) were calculated and compared with age- and sex-matched controls.27304785
diabetic, Diabetes MellitusDeregulated Nutrient SensingFurthermore, diabetic keratinocytes displayed insulin resistance and increased expression of pro-inflammatory cytokines demonstrating the persistent effect of diabetes mellitus on human skin cells.27306297
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingThe most frequent risk factors were MS and its variables: increased waist circumference, dyslipidemia and HBP.27310544
amyloid-beta binding, DyslipidemiasDeregulated Nutrient SensingAlthough many preclinical studies have suggested the possible linkage between dyslipidemia and cerebral amyloid deposition, the association between serum lipid measures and cerebral amyloid-beta (Ab) deposition in human brain is still poorly known.27311886
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMedication and remission results for hypertension and dyslipidemia did not differ significantly between groups.27312346
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM).27313402
TG gene, InflammationDeregulated Nutrient SensingPlasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance.27313402
Rheumatoid ArthritisDeregulated Nutrient SensingEffects of prednisolone on energy and fat metabolism in patients with rheumatoid arthritis: tissue-specific insulin resistance with commonly used prednisolone doses.27321736
LipolysisDeregulated Nutrient SensingAttenuated postprandial suppression of fat oxidation, but not lipolysis, suggests that prednisolone causes greater insulin resistance in skeletal muscle than in adipocytes.27321736
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingDyslipidemia and low levels of high density lipoprotein cholesterol (HDL-C) can increase the risk of atherosclerosis development in people with type 2 diabetes mellitus (T2DM).27322526
Coronary heart diseaseDeregulated Nutrient SensingRanolazine improves insulin resistance in non-diabetic patients with coronary heart disease.27323337
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingThe aim of this pilot study was to evaluate if ranolazine (R) could improve insulin resistance (IR) in obese/overweight non-diabetic patients with coronary heart disease (CHD).27323337
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCurrent researcn in type 2 diabetes mellitus focuses on the role of Peroxisome- Proliferator Activated Receptors (PPARs) in the pathogenesis of the Insulin Resistance Syndrome (IRS), which are pre-diabetic lesion and the hallmark of fully developed type 2 diabetes mellitus.27323578
ETV3 wt AlleleDeregulated Nutrient SensingSimilarly, the MetS (or its individual components), insulin resistance and increased serum uric acid levels were also independently associated with LSM>7.0 kPa.27324703
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLegume consumption and its association with fasting glucose, insulin resistance and type 2 diabetes in the Indian Migration Study.27329792
Diabetes MellitusDeregulated Nutrient SensingAlthough legumes are essential in traditional Indian diets, as well as in prudent and Mediterranean diets in the West, we did not find an association between legumes and markers of glycaemic control, insulin resistance or diabetes, except for subgroups based on BMI and macronutrient intake.27329792
Dyslipidemias, CalcinosisDeregulated Nutrient SensingDyslipidemia, moderate-severe calcification, and first-year AV-Vel progression >=0.22 m/s/year were independent predictors of cardiac events.27334030
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingMultiple logistic regression analyses showed that dyslipidaemia, BMI and 2-h postprandial plasma glucose were independent risk factors for non-alcoholic fatty liver disease, while heart rate and female gender were protective factors.27334577
Diabetes MellitusDeregulated Nutrient SensingVitamin D3-Supplemented Yogurt Drink Improves Insulin Resistance and Lipid Profiles in Women with Gestational Diabetes Mellitus: A Randomized Double Blinded Clinical Trial.27336154
Gestational DiabetesDeregulated Nutrient SensingDaily consumption of VDY drink improves insulin resistance and lipid profiles in women with GDM.27336154
Prostate Cancer Outcomes Study, HyperandrogenismDeregulated Nutrient SensingPCOS patients above the 75th percentile for UFC and/or 17OHS after high-dose dexamethasone (n = 15) had a significantly smaller total adrenal volume (6.9 +- 1.9 cm(3) vs 9.2 +- 1.8 cm(3), P = .003) when compared with the remaining PCOS patients (n = 22), but they did not have worse insulin resistance or hyperandrogenism.27336356
Old ageDeregulated Nutrient SensingDepletion of SIRT1 by knockdown or SIRT1 inhibitor EX527 abrogated the antisenescence effect of a7nAChR against Ang II.27339462
Vascular DiseasesDeregulated Nutrient SensingOur results demonstrate that activation of a7nAChR alleviates Ang II-induced VSMC senescence through promoting NAD(+)-SIRT1 pathway, suggesting that a7nAChR may be a potential therapeutic target for the treatment of Ang II-associated vascular aging disorders.27339462
Prostate carcinomaDeregulated Nutrient SensingRelationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer.27340081
Primary malignant neoplasmDeregulated Nutrient SensingADT is associated with increased insulin resistance and frailty within 12months of commencement, independently of confounding effects of cancer or radiotherapy.27340081
Rheumatoid ArthritisDeregulated Nutrient SensingInfluence of Insulin Resistance and TNF-a on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis.27340510
Refractory anemias, Rheumatoid ArthritisDeregulated Nutrient SensingThe aim of this study was to evaluate the involvement of TNF-a and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA).27340510
Refractory anemiasDeregulated Nutrient SensingSimilarly, features of insulin resistance were absent in RA patients (p = non-significant).27344073
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe M2BP levels in subjects with hypertension, dyslipidemia, or abnormal glucose metabolism were higher than those in subjects without such risk factors.27344370
Diabetes MellitusDeregulated Nutrient SensingAssociation of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial.27347563
Blood GlucoseDeregulated Nutrient SensingThe high FOXC2 expressions in visceral adipose tissues are manifested as reduction of blood glucose and blood lipid levels, thereby reducing insulin resistance.27349002
Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingWe recruited patients with ACS and dyslipidemia who had undergone coronary angiography.27349705
fibrillinDeregulated Nutrient SensingMoreover, TH treatment increased intracutaneous fibrillin-rich microfibril and collagen III deposition and decreased mammalian target of rapamycin (mTORC1/2) expression ex vivo.27349864
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is frequently associated with insulin resistance (IR) and abnormalities in glucose metabolism.27351871
Increased insulin level, Hypoglycemia, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingPrevalent postprandial hyperinsulinemia along with insulin resistance in NAFLD may lead to hypoglycemia.27351871
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTeneligliptin, a chemotype prolyl-thiazolidine-based novel dipeptidyl peptidase (DPP)-4 inhibitor, was preliminarily shown to reduce insulin resistance in patients with type 2 diabetes mellitus (T2DM).27352309
Hyperglycemia, Breast CarcinomaDeregulated Nutrient SensingConsumption of Fresh Yellow Onion Ameliorates Hyperglycemia and Insulin Resistance in Breast Cancer Patients During Doxorubicin-Based Chemotherapy: A Randomized Controlled Clinical Trial.27352956
HyperglycemiaDeregulated Nutrient SensingThe present study demonstrated the effectiveness of onion to ameliorate hyperglycemia and insulin resistance in BC during doxorubicin-based chemotherapy.27352956
hepatitis B virusDeregulated Nutrient SensingProtection of CD4+ T cells from hepatitis C virus infection-associated senescence via DNp63-miR-181a-Sirt1 pathway.27354409
Hypermetabolism, Burn Specimen Source Codes, Inflammation, HyperglycemiaDeregulated Nutrient SensingInflammation and hypermetabolism post burn predisposes to hyperglycemia and insulin resistance.27355659
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe occurrence of ChP DNA in the aortic tissue is related to classic CAD risk factors such as diabetes and dyslipidemia.27358129
Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingGender, smoking, dyslipidemia (DL), and diabetes mellitus (DM), in addition to FMD-AUC120, were identified as significant independent variables that predicted the presence of CAD by a multivariate logistic regression.27359079
Dyslipidemias, Diabetes Mellitus, Heart Diseases, Hepatobiliary Disorder, Kidney Diseases, Hypertension, CTCAEDeregulated Nutrient SensingThere were no obvious differences in age, gender ratio, body mass index, hypertension, dyslipidemia, diabetes, kidney disease, liver disease, heart disease, or drinking or smoking habits between carriers and non-carriers.27365075
Endothelial dysfunction, AtherosclerosisDeregulated Nutrient SensingAngiopoietin-like protein 2 (ANGPTL2), a proinflammatory mediator, has been reported to accelerate the development of insulin resistance, endothelial dysfunction, and atherosclerosis in mice.27365403
InflammationDeregulated Nutrient SensingChronic low-grade inflammation and insulin resistance are intimately related entities that are common to most, if not all, chronic diseases of affluence.27366752
Mood Disorders, Dyslipidemias, Metabolic Syndrome X, ObesityDeregulated Nutrient SensingAffective disorders are associated with increased frequencies of CVD risk-factors such as obesity, dyslipidemia, and metabolic syndrome.27367307
Degenerative polyarthritisDeregulated Nutrient SensingHowever, the role of Sirt1 in the OA chondrocytes still remains unknown.27367673
Degenerative polyarthritisDeregulated Nutrient SensingThe expression of Sirt1 was ubiquitously observed in osteoarthritic chondrocytes; in contrast, Runx2 expressed in the osteophyte region in patients with OA and OA model mice.27367673
Degenerative polyarthritisDeregulated Nutrient SensingOA chondrocytes, which were pretreated with Sirt1 inhibitor, inhibited the IL-1b-induced expression of Runx2 compared to the control.27367673
Degenerative polyarthritis, InflammationDeregulated Nutrient SensingSince Sirt1 activity is known to be affected by several stresses, including inflammation and oxidative stress, as well as aging, SIRT may be involved in the development of OA.27367673
Degenerative polyarthritisDeregulated Nutrient SensingThe NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis.27367673
OverweightDeregulated Nutrient SensingAmong overweight middle-aged men with glucose-intolerance, ILS increased endogenous testosterone slightly but without significant improvements in mood.27371769
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe investigated risk factors were hypertension, hyperglycaemia, and dyslipidaemia.27372206
DyslipidemiasDeregulated Nutrient SensingOf those with a recorded assessment, elevated BGL (39%, 479/1,244), smoking (63%, 649/1,033), overweight/obesity (51%, 381/743) and dyslipidaemia (73%, 458/625) were common.27372907
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThe difference suggest that postprandial lipid induced glucose intolerance (LGIT) may serve as a further valuable marker for early diabetes prediction.27373781
Diffuse Large B-Cell LymphomaDeregulated Nutrient SensingThe PI3K-mTORC pathway is upregulated in diffuse large B-cell lymphoma (DLBCL) and can be targeted with the mTOR complex 1 (mTORC1) inhibitor everolimus.27374464
Diffuse Large B-Cell LymphomaDeregulated Nutrient SensingThe mTORC1 inhibitor everolimus given for 14 days in combination with R-CHOP-21 for patients with DLBCL is safe.27374464
Renal Insufficiency, Inflammation, Thyroid dysfunctionDeregulated Nutrient SensingOur results are as follows: (1) 25-(OH)D was significantly lower than expected (19.48+-9.51 and 18.01+-9.01 (ng/mL+SD) in males and females, respectively); (2) seasonal variation of 25-(OH)D was observed in both sexes (females < males), with values peaking in August; (3) a decline of 25-(OH)D was evident with advancing age, with lower levels in females compared to males up to menopause and no apparent difference between the genders thereafter; (4) levels of 25-(OH)D were lower in renal function impairment, diabetes/insulin resistance and inflammation, while no correlation was detectable in thyroid dysfunction; (5) normalization of PTH levels was observed at ~20 ng/mL 25-(OH)D. At the same cut-off level, a significant decrease of all measured bone turnover indices (b-ALP, osteocalcin and CTX) was evident.27376424
Abnormal mitochondria in muscle tissueDeregulated Nutrient SensingBoth inherited and acquired insulin resistance have been associated with abnormal muscle mitochondrial function.27376543
Dyslipidemias, Neurologic SymptomsDeregulated Nutrient SensingSensitivity analysis in patients with dyslipidemia (n = 1,998) also showed the same trend between pre-stroke statin treatment and mild neurological symptoms (multivariable-adjusted OR 1.26; 95% CI 0.99-1.62; p = 0.06).27376661
DyslipidemiasDeregulated Nutrient SensingAge and BMI were positively correlated with increase in the risk of dyslipidemia.27377682
DyslipidemiasDeregulated Nutrient SensingAge and BMI are positively correlated with increasing dyslipidemia in my population.27377682
ObesityDeregulated Nutrient SensingCirculating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.27378396
ObesityDeregulated Nutrient SensingSIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events.27378396
ObesityDeregulated Nutrient SensingSIRT1 was significantly lower (P = 0.002) and EFT was higher (P < 0.0001) in patients with obesity compared with lean controls.27378396
ObesityDeregulated Nutrient SensingSIRT1 showed a negative correlation with EFT and HR in the obesity group (r = -0.350, P = 0.005; r = -0.303, P = 0.008, respectively).27378396
Coronary Artery Disease, ObesityDeregulated Nutrient SensingSerum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity.27378396
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe used a questionnaire survey for the presence of cerebrovascular risk factors (CVRFs) such as arterial hypertension, smoking and dyslipidemia, among others, as well as instrumental (Doppler examination) and neurological magnetic resonance imaging (MRI) procedures.27381108
Non-alcoholic Fatty Liver Disease, diabeticDeregulated Nutrient SensingOur data suggests that SUA is specifically associated with NAFLD in male type 2 diabetic subjects, independent of insulin resistance and other metabolic factors.27382573
Dyslipidemias, Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingRegarding the ASCVD risk factors, 17.0% of the study subjects smoked, 5.2% abused alcohol, 2.0% had a family history of ASCVD, 23.3% had diabetes and 96.0% had dyslipidemia.27383508
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is a metabolic disease characterized by insulin resistance, and is associated with the effects of genetic and environmental factors.27383530
Ulcer, Systemic SclerodermaDeregulated Nutrient SensingInsulin resistance is associated with digital ulcer in patients with systemic sclerosis.27383539
Ulcer, Sample Size Calculation, Systemic SclerodermaDeregulated Nutrient SensingTo investigate the relationship between insulin resistance and digital ulcers (DUs) in patients with systemic sclerosis (SSc).27383539
Sample Size CalculationDeregulated Nutrient SensingInsulin resistance was independently associated with the presence of DUs in patients with SSc and may be a potential biomarker for SSc micro-vasculopathy.27383539
Dyslipidemias, Depression, CTCAE, Diabetes MellitusDeregulated Nutrient SensingEighteen (36%) of the patients were current smokers, 10 (20%) had depression, 7 (14%) had dyslipidemia, and 7 (14%) had diabetes mellitus.27383930
ARCN1 gene, Dyslipidemias, Depression, CTCAEDeregulated Nutrient SensingCurrent smoking, depression, and dyslipidemia were more prevalent among the patients with mild-to-moderate COPD than among those with severe-to-very severe COPD (p < 0.001, p = 0.008, and p = 0.02, respectively).27383930
ARCN1 gene, Dyslipidemias, Depression, CTCAEDeregulated Nutrient SensingCertain risk factors for CVD, themselves classified as diseases (including smoking, dyslipidemia, and depression), appear to be more prevalent in patients with mild-to-moderate COPD.27383930
Hypertension, CTCAE, Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingHypertension and dyslipidaemia were significantly associated with CHD outcome in males and ABSI (a body shape index) in females.27386836
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAcylcarnitines were suggested as early biomarkers even prior to insulin resistance in animal studies, but their roles in predicting type 2 diabetes were unknown.27388475
Dyslipidemias, HepatomegalyDeregulated Nutrient SensingAlterations in glucose homeostasis, dyslipidemia, hepatomegaly and obese phenotype were evident from the very beginning in males with an increased hepatic inflammatory activity.27391242
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients' hypertension stage, cardiovascular disease history, diabetes family history, dyslipidemia, and hospital level were associated with higher odds of glucose tests prescription.27392259
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingEffects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease: assessment of clinical usefulness in CKD patients with atorvastatin (ASUCA) trial.27392909
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is a risk factor for the progression of chronic kidney disease (CKD).27392909
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingThe prevalence of hyperlipidemia (from 13.3%; 95% confidence interval [CI], 11.6%-15.0% to 24.5%; 95% CI, 22.4%-26.6%; P < 0.001) and dyslipidemia (from 18.8%; 95% CI, 16.9%-20.7% to 28.9%; 95% CI, 26.7%-31.3%; P < 0.001) also increased from 2004 to 2014.27397598
Diabetes Mellitus, Non-Insulin-Dependent, Myocardial IschemiaDeregulated Nutrient SensingInsulin resistance measured by eGDR could be a useful risk marker in patients with type 2 diabetes and ischemic heart disease.27401741
Xanthoma, Dyslipidemias, SitosterolemiaDeregulated Nutrient SensingInfants presenting with multiple xanthomas should be investigated for sitosterolemia, if there is no family history of dyslipidemia.27401767
Pancreatitis, Acute, HyperglycemiaDeregulated Nutrient SensingInterleukin-6 is associated with chronic hyperglycemia and insulin resistance in patients after acute pancreatitis.27401909
Pancreatitis, Acute, HyperglycemiaDeregulated Nutrient SensingInterleukin-6 appears to be implicated in the development of chronic hyperglycemia and insulin resistance in patients after acute pancreatitis.27401909
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAge, cardiovascular risk factors (smoking, systemic arterial hypertension, dyslipidemia and diabetes) and alcohol drinking habit were investigated.27402474
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingAt baseline, 3 patients had dyslipidemia, 4 had diabetes, and 5 patients had hypertension, which did not change at follow-up.27405478
Colorectal CarcinomaDeregulated Nutrient SensingWe further revealed a novel mechanism in which ICT1 promoted CRC growth via the intracellular AMPK, SAPK/JNK, and PARP signaling pathways.27411551
Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Anemia, Renal Insufficiency, Hypertension, CTCAEDeregulated Nutrient SensingPatients with HFpEF were more likely to be older, female, and have comorbid hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, anemia, and renal dysfunction.27413034
DyslipidemiasDeregulated Nutrient SensingPatients with mixed dyslipidaemia exhibit low numbers of circulating CD34(+) and CD34(+)/KDR(+) cells as well as CFU-ECs in culture, a defect restored by 3-month treatment with either high-rosuvastatin dose or a combination of low-rosuvastatin dose with o-3 PUFAs.27415612
Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus (DM) is a heterogeneous disease characterised by an absolute or relative deficiency of insulin and insulin resistance.27416617
Cryoglobulinemia, Lupus ErythematosusDeregulated Nutrient SensingA systemic lupus erythematosus patient presenting as type B insulin resistance complicated with cryoglobulinemia.27416845
Cryoglobulinemia, Lupus Erythematosus, SystemicDeregulated Nutrient SensingWe reported a 63-year-old male patient with SLE presenting as type B insulin resistance (TBIR) complicated with cryoglobulinemia.27416845
Infertility, Anxiety, CTCAE 3.0Deregulated Nutrient SensingNo statistically significant correlation between BDI or state anxiety and the level of the analyzed hormones, insulin resistance, or infertility treatment, was found.27418215
Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPrevalence of dyslipidemia and hypertension were almost 50% higher and prevalence of obesity was two times higher (all p values<0.05).27423091
Inflammation, Atherosclerosis, Sleep disturbances, Endothelial dysfunction, Hypertension, CTCAEDeregulated Nutrient SensingNumerous biological pathways linking sleep disturbances to atherosclerosis have been identified, such as insulin resistance, inflammation, hypertension, and endothelial dysfunction.27423537
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased iron is associated with type 2 diabetes, dyslipidemia, and high blood pressure.27426616
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt has been proposed that the energy-sensing enzyme AMP-activated protein kinase (AMPK) is a key agent in the pathophysiology of type 2 diabetes mellitus (T2DM).27427333
Dyslipidemias, DysglycemiaDeregulated Nutrient SensingDyslipidemia and dysglycemia are etiologically associated, but the direction, chronology, and mechanisms of the association are not fully understood.27430991
Dyslipidemias, DysglycemiaDeregulated Nutrient SensingThese findings suggest that early lifestyle intervention could ameliorate progressive dyslipidemia and dysglycemia.27430991
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe cumulative incidence of de novo diabetes, hypertension, and dyslipidemia were 16.9%, 31.2%, and 6.5%, respectively.27434676
Cardiac Arrest, DyslipidemiasDeregulated Nutrient SensingCompared with no-PHAS patients, patients in the PHAS group were predominantly women, and presented more frequently with dyslipidemia and cardiac arrest.27436141
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingParticipants in the top quartile of DASH diet score were 30% less likely to have NAFLD (OR: 0.0.70; 95% CI: 0.61, 0.80); however, more adjustment for dyslipidemia and body mass index changed the association to non-significant (OR: 0.92; 95% CI: 0.73, 1.12).27436528
Diabetes MellitusDeregulated Nutrient SensingReduction Levels and the Effects of High-Molecular-Weight Adiponectin via AMPK/eNOS in Chinese Type 2 Diabetes.27437915
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAim: This study was to investigate the change of high-molecula-weight (HMW) adiponectin (APN) isoform, the association between type 2 diabetes mellitus (T2DM) and HMW APN isoform, the variation of Disulfide-bond A oxidoreductase-like protein (DsbA-L), the effect of HMW APN isoform on AMP-dependent protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS) in Chinese T2DM.27437915
Dyslipidemias, ObesityDeregulated Nutrient SensingYounger age, obesity, smoking, and uncontrolled dyslipidemia were associated with poor glycemic control.27437997
DyslipidemiasDeregulated Nutrient SensingBy the other hand, dyslipidemia were more common among monoinfected patients.27438424
Proteinuria, Dyslipidemias, Hepatitis CDeregulated Nutrient SensingAlthough coinfected patients had higher prevalence of tenofovir-based regimen, there was a strong association between hepatitis C virus individuals to pathological proteinuria and dyslipidemia.27438424
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe aimed to replicate the associations between an S100A9 variant and insulin resistance and T2D and to initiate an investigation of potential interactions with the habitual diet in several independent populations.27440084
HyperglycemiaDeregulated Nutrient SensingThis hormonal state may be detrimental for surgical patients due to the presence of insulin resistance and hyperglycemia.27442397
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWomen were more likely than men to have diabetes mellitus, hypertension, and dyslipidemia, but current smoking was higher in men than in women.27442655
Myocardial IschemiaDeregulated Nutrient SensingInsulin resistance (IR), constitutes an important cardiovascular risk factor and can cause ischemic heart disease.27448539
Arterial Stiffness, Coronary Artery DiseaseDeregulated Nutrient SensingInsulin resistance is associated with subclinical myocardial and vascular alterations in patients without significant coronary artery disease, measured as a reduction of Global Longitudinal Strain, and increased arterial stiffness.27448539
Dyslipidemias, Impaired cognitionDeregulated Nutrient SensingTreatment of dyslipidemia may be an effective strategy to reduce cognitive decline in older HIV(+) individuals.27448678
HD Term Type, DyslipidemiasDeregulated Nutrient SensingIn HD patients, lower plasma adropin concentration is associated with dyslipidemia.27449397
Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAtherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study.27450534
Coronary Arteriosclerosis, Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate whether atherogenic dyslipidemia, a dyslipidemic profile combining elevated triglycerides and low high-density lipoprotein (HDL) cholesterol, is predictive of risk of silent myocardial ischemia (SMI) or angiographic coronary artery disease (CAD) in asymptomatic patients with type 2 diabetes.27450534
DyslipidemiasDeregulated Nutrient SensingOverall, 60 (5.5 %) patients had atherogenic dyslipidemia (triglycerides >=2.26 mmol/L and HDL cholesterol <=0.88 mmol/L).27450534
Dyslipidemias, Retinal Diseases, Peripheral arterial occlusive diseaseDeregulated Nutrient SensingIn multivariate analyses taking into account the parameters associated in univariate analyses with SMI and then CAD, atherogenic dyslipidemia was associated with SMI (odds ratio 1.8[1.0-3.3]), as were male gender (OR 2.1[1.5-2.9]), BMI (OR 0.97[0.94-0.997]), retinopathy (OR 1.4[1.1-1.9]), peripheral occlusive arterial disease (POAD: OR 2.5[1.6-3.8]) and mean blood pressure (OR 1.01[1.00-1.03]); atherogenic dyslipidemia was associated with CAD (OR 4.0[1.7-9.2]), as were male gender (OR 3.0[1.6-5.6]), BMI (OR 0.94[0.90-0.995]), retinopathy (OR 1.7[1.0-2.9], POAD (OR 4.0[2.1-7.4]) and mean blood pressure (OR 1.03[1.01-1.05]).27450534
DyslipidemiasDeregulated Nutrient SensingIn the subgroup of 584 patients with LDL cholesterol <2.6 mmol/L, atherogenic dyslipidemia was also associated with CAD (OR 3.6[1.5-9.0]).27450534
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAtherogenic dyslipidemia was associated with an increased risk of SMI and silent CAD in patients with type 2 diabetes and LDL cholesterol levels <3.35 mmol/L.27450534
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingSpecific management of atherogenic dyslipidemia might help reducing the high residual burden of cardiovascular disease.27450534
Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, diabeticDeregulated Nutrient SensingOverall, 58.8% of the patients had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1% had a smoking history (current or past), 25.8% had a family history of coronary artery disease (CAD) and 24.1% had a prior history of CAD.27451914
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn addition, the estimated indices of baseline insulin resistance increased in group A. Fasting insulin level, body mass index, systolic blood pressure at baseline and the shortening of telomere length were independent risk factors of NAFLD in type 2 diabetes mellitus patients.27451965
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus patients who developed NAFLD had more serious insulin resistance compared with those who did not develop NAFLD a long time ago.27451965
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingINTRODUCTION Lowering exposure to dyslipidemias is one of the biggest challenges in cardiovascular disease prevention.27452484
Kidney Failure, ChronicDeregulated Nutrient SensingAdropin and irisin levels in relation to nutrition, body composition, and insulin resistance in patients with end-stage renal disease on chronic hemodialysis and peritoneal dialysis.27452672
Kidney Failure, Chronic, CachexiaDeregulated Nutrient SensingAdropin and irisin should be further investigated as possible markers of cachexia and insulin resistance in patients with ESRD.27452672
AtherosclerosisDeregulated Nutrient SensingExcess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation.27455039
ACACA wt AlleleDeregulated Nutrient SensingThis was associated with an increase in AMPK and ACC, phosphorylation, and increased fatty acid oxidation, which was prevented by AMPK or Sirt inhibition or silencing.27456392
Diabetes Mellitus, Insulin-Dependent, Inflammation, IGHD1-7 geneDeregulated Nutrient SensingPatients with type 1 diabetes (DM1) have distinct gut microbiota in comparison to non-diabetic individuals, and it has been linked to changes in intestinal permeability, inflammation and insulin resistance.27456494
PathologyDeregulated Nutrient SensingFurthermore, c-Jun N-terminal kinase activation, which plays a pivotal role in insulin resistance and AD pathologies, is significantly inhibited.27457264
Diabetes MellitusDeregulated Nutrient SensingBody circumferences have been proposed as potential anthropometric measures for the assessment of cardiometabolic risk as they are independently associated with insulin resistance and diabetes.27457430
DyslipidemiasDeregulated Nutrient SensingThe association of BCAAs with lipids or with the risk of metabolic dyslipidemia was analyzed.27457614
DyslipidemiasDeregulated Nutrient SensingElevated serum BCAAs level are positively associated with incident metabolic dyslipidemia.27457614
Non-alcoholic Fatty Liver Disease, physiopathologicalDeregulated Nutrient SensingPFF was independently associated with increased total adiposity but did not correlate with AT dysfunction, insulin resistance and secretion or NAFLD.27458255
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance and b-cell function are different between the young and elderly diabetes individuals, which are not well elaborated in the nondiabetic persons.27459384
Increased insulin level, Gout, Diastolic dysfunction, Hyperleucinemia, Electrocardiogram: left ventricle hypertrophy (finding), Hypoadiponectinemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe study demonstrated compensatory hyperinsulinemia and insulin resistance, hypoadiponectinemia, hyperleptinemia, left ventricular hypertrophy, diastolic dysfunction, and intact ventricular contractility in patients with type 2 diabetes, gout, and their combination.27459761
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAlthough these had improved slightly from 2009 to 2012, diabetes co-morbidities (hypertension and dyslipidaemia) and complications had also increased.27459893
Cerebrovascular Disorders, Diabetes MellitusDeregulated Nutrient SensingPioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease.27465265
Electrocardiogram: myocardial infarction (finding), Cerebrovascular accident, Diabetes Mellitus, Tacca leontopetaloides, Ischemic stroke, BRCA1 wt AlleleDeregulated Nutrient SensingThe Insulin Resistance Intervention after Stroke (IRIS) trial recently found that pioglitazone reduced risk for stroke and myocardial infarction in patients with insulin resistance but without diabetes who had had a recent ischemic stroke or transient ischemic attack (TIA).27465265
Tacca leontopetaloides, Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingAmong patients with insulin resistance but without diabetes who had had a recent ischemic stroke or TIA, pioglitazone decreased the risk of diabetes while also reducing the risk of subsequent ischemic events.27465265
Increased insulin level, DamageDeregulated Nutrient SensingHerein, we tried to search the role of hyperinsulinism and insulin resistance as a new predictor of primary AVF failure (pAVFF) that may be a cause of intimal damage.27466042
Increased insulin levelDeregulated Nutrient SensingInsulin resistance or hyperinsulinism may be a significant cause of pAVFF, which emphasizes the role of endothelium in fistula dysfunction.27466042
Obesity, Diabetes MellitusDeregulated Nutrient SensingTaurine metabolism disturbance is closely linked to obesity, insulin resistance, and diabetes.27466884
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAssociation of obesity with hypertension and dyslipidemia in type 2 diabetes mellitus subjects.27477531
Hypertriglyceridemia, Dyslipidemias, ObesityDeregulated Nutrient SensingDyslipidemia, except for hypertriglyceridemia, was correlated to neither abdominal nor general obesity.27477531
DysglycemiaDeregulated Nutrient SensingInsulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise.27477619
AdrenoleukodystrophyDeregulated Nutrient SensingAlthough the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated.27477770
ciliary vesicleDeregulated Nutrient SensingHigh-intensity interval training (HIIT) has been shown to reduce insulin resistance and other CV disease risk factors to a greater degree than moderate-intensity continuous training (MICT).27480182
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most common comorbidities were hypertension (54 %), dyslipidemia (33 %), a history of smoking (30 %), and diabetes (26 %).27480417
Data types - AddressDeregulated Nutrient SensingIn conclusion, altered markers including AMPK, ER stress and AD related makers under obese condition could be easily obtained from PBMCs.27481183
DyslipidemiasDeregulated Nutrient SensingThe Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians.27483306
DyslipidemiasDeregulated Nutrient SensingHigher vitamin D status may protect the endothelium through reduced dyslipidaemia and increased HGF.27483306
Glucose Intolerance (disease)Deregulated Nutrient SensingBlood examinations revealed an inflammatory reaction, worsened glucose intolerance, and an increased level of serum IgG4 (137 mg/dL).27484098
Senile Plaques, Data types - AddressDeregulated Nutrient SensingOverall, our results support the hypothesis that the miR-132/212 network, including Sirt1 and likely other target genes, contributes to abnormal Ab metabolism and senile plaque deposition in AD.27484949
Diabetes Mellitus, Non-Insulin-Dependent, Obesity, AtherosclerosisDeregulated Nutrient SensingBACKGROUND Human fetuin A (AHSG) has been associated with the development of obesity, insulin resistance, type 2 diabetes mellitus, and atherosclerosis.27487851
Carotid Intima-Media ThicknessDeregulated Nutrient SensingBrachial artery flow-mediated dilatation and carotid intima-media thickness in young ED patients with insulin resistance.27488226
Diabetes MellitusDeregulated Nutrient SensingWestern blot analysis showed that diabetes induces accumulated lipid peroxidation products and escalated AMP-activated protein kinase-LKB1 pathway.27488451
Diabetes MellitusDeregulated Nutrient SensingALDH2 deficiency potentiates oxidative stress and AMPK phosphorylation induced by diabetes via post-translational regulation of LKB1.27488451
Presenile dementiaDeregulated Nutrient SensingInsulin resistance (IR) is associated with poor cerebrovascular health and increased risk for dementia.27488909
IGHD1-7 geneDeregulated Nutrient SensingSignificant insulin resistance was found in DM1 that might be responsible for FGF21 elevation.27489983
Mitochondrial DiseasesDeregulated Nutrient SensingConclusions FGF21 elevation may be associated with certain types of mitochondrial disease, and it is influenced by insulin resistance.27489983
ObesityDeregulated Nutrient SensingThe major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy.27490249
Certified MidwifeDeregulated Nutrient SensingThe effects of CM were related to the reduction in p53 acetylation which would be dependent on the enhancement of Sirtuin 1 expression.27490266
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingSoy isoflavone administration for 12 weeks in women with PCOS significantly improved markers of insulin resistance, hormonal status, triglycerides, and biomarkers of oxidative stress.27490918
InflammationDeregulated Nutrient SensingBiomarkers of subclinical inflammation and increases in glycaemia, insulin resistance and beta-cell function in non-diabetic individuals: the Whitehall II study.27491375
InflammationDeregulated Nutrient SensingSubclinical inflammation is associated with development of increased glycaemia, insulin resistance and beta-cell function in non-diabetic individuals.27491375
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingA high serum angiopoietin-like 2 (ANGPTL2) concentration is an independent risk factor for developing diabetes and is associated with insulin resistance and atherosclerosis.27491833
Dyslipidemias, Family historyDeregulated Nutrient SensingThe percentage of patients with possible or probable FH in various countries was examined in the Dyslipidemia International Study (DYSIS).27494444
SLC25A20 gene, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (b = 0.64 and 0.63, respectively) in males and diabetes (b = 1.08) followed by smoking (b = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores.27494449
SLC25A20 gene, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHowever, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females.27494449
Hypertensive disease, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTherefore, we reviewed published studies on CVD modifiable risk factors e.g., Type 2 Diabetes Mellitus (T2DM), hypertension (HTN), dyslipidemia and smoking as well as studies on CVDs and conducted a meta-analysis of risk factors and disease prevalence.27494706
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingMedian (IQR) prevalence of T2DM, HTN, dyslipidemia and smoking were 5.9% (1.97%-8.25%); 15.1% (10.52%-17.60%); 34.35% (10.66%-48.50%) and 40.56% (0.80%-55.95%), respectively.27494706
DyslipidemiasDeregulated Nutrient SensingThe prevalence of T2DM and dyslipidemia were significantly higher in urban compared to rural populations (13.5 vs 6%, p<0.001; 41.5 vs 30%, p = 0.007, respectively).27494706
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingThere were 74 eligible studies (outcome: T2DM = 32, HTN = 24, dyslipidaemia = 8 and smoking = 25; CVDs = 10).27494706
Dyslipidemias, GDC Comorbidity Terminology, Cerebrovascular accidentDeregulated Nutrient SensingComorbid conditions included dyslipidemia, stroke, and 12 other chronic conditions.27495110
Disability, Dyslipidemias, Chronic lung disease, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia, chronic lung disease, stroke, memory-related diseases, and arthritis/rheumatism were associated with BADL disability.27495110
ProgranulinsDeregulated Nutrient SensingProgranulin, an adipokine with proinflammatory and insulin resistance-inducing characteristics, has not been investigated in LD so far.27497155
Cognition Disorders, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCholesteryl Ester Transfer Protein Intimately Involved in Dyslipidemia-Related Susceptibility to Cognitive Deficits in Type 2 Diabetic Patients.27497473
DyslipidemiasDeregulated Nutrient SensingCholesteryl ester transfer protein (CETP) is involved in diabetic dyslipidemia.27497473
Cognition Disorders, diabeticDeregulated Nutrient SensingWe aim to test the hypothesis that CETP might be of importance in mediating dyslipidemia-related susceptibility to cognitive deficits in diabetic patients.27497473
Dyslipidemias, millicurie, diabeticDeregulated Nutrient SensingDyslipidemia is more common among diabetic patients with MCI; they had a significant increase of serum CETP concentrations, which was negatively correlated with MoCA (r = -0.638; p < 0.001).27497473
Impaired cognition, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCETP was intimately involved in dyslipidemia-related susceptibility to cognitive decline, especially memory function in type 2 diabetic patients.27497473
ObesityDeregulated Nutrient SensingIncreased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice.27498874
ObesityDeregulated Nutrient SensingStrikingly, restoring 4E-BP1 expression in male mice protects them against HFD-induced obesity and insulin resistance.27498874
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingResults Hypertension, dyslipidaemia and type 2 diabetes mellitus were prevalent (>=55% of 40 patients).27503947
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSignificant differences in EAT thickness were found between patients stratified by NO value, FMD, age, smoking status, dyslipidaemia, type 2 diabetes mellitus and FS.27503947
Increased insulin levelDeregulated Nutrient SensingHyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in the presence of insulin resistance.27504013
Increased insulin levelDeregulated Nutrient SensingTherefore, glucose maintenance during insulin resistance may depend not only on hyperinsulinemia but also on the ability to suppress glucagon early after glucose intake.27504013
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingThere were diverse dyslipidemia phenotypes in patients with NAFLD.27506745
Hyperlipidemia, Hypertriglyceridemia, Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingCombined hyperlipidemia, MetS dyslipidemia, and hypertriglyceridemia were strongly and independently associated with increased risk of NAFLD.27506745
Thrombus, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOn multivariate regression analysis, aPL, age, hypertension, dyslipidaemia and baseline C-reactive protein level were independently associated with arterial thrombotic events (all P values < 0.05).27510601
Primary malignant neoplasm, Cardiovascular Diseases, ETV3 wt Allele, ObesityDeregulated Nutrient SensingThe high prevalence of obesity and metS and the observed underlying condition of insulin resistance expose this population to an increased risk of cardiovascular disease and cancer despite the healthy nutritional habits.27511705
Inflammation, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingA vegetarian diet may prevent elevation of blood pressures and lower the risk for hypertension through lower degrees of obesity, inflammation, and insulin resistance.27512965
Inflammation, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingVegetarian diets may protect against hypertension beyond lower abdominal obesity, inflammation, and insulin resistance.27512965
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingOverall, 72.8 and 64.8% of patients had hypertension and dyslipidaemia, respectively; 47.0% had both conditions.27512970
Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingTraditional cardiovascular risk factors, such as hypertension and dyslipidemia, predispose individuals to cardiovascular disease, particularly patients with diabetes.27513651
Dyslipidemias, ObesityDeregulated Nutrient SensingVariables independently associated (p < 0.05) with sedentariness were age, sex, BMI, central obesity, Mediterranean diet adherence, smoking habit, HDL-cholesterol, triglycerides and dyslipidemia.27532610
GainDeregulated Nutrient SensingThe influence of insulin and insulin resistance (IR) on children's weight and fat gain is unclear.27534840
NeoplasmsDeregulated Nutrient SensingWe demonstrated that metformin attenuates ERK signaling by activating AMPK pathway leading to suppression of Snail and Slug resulting in upregulation of crucial tumor suppressor gene E-cadherin.27534967
Primary malignant neoplasmDeregulated Nutrient SensingTo our knowledge this is the first report representing an inverse relationship of AMPK and ERK signaling axis in promoting mesenchymal to epithelial transition (MET) via re-expression of E-cadherin upon metformin treatment thus rationalizing lower incidence of cancer in metformin-administered patients.27534967
Hypoglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Blood GlucoseDeregulated Nutrient SensingIn patients with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin monotherapy, the addition of alogliptin contributed to clinically significant increases in pulmonary function through regulating glycemia and improving the imbalance of the oxidative-related substances in the serum, without increasing the incidence of hypoglycemia, dyslipidemia, dysarteriotony, and any notable increase in body weight.27537577
Cardioembolic stroke, Dyslipidemias, Atrial Fibrillation by ECG Finding, Periventricular white matter hyperdensitiesDeregulated Nutrient SensingAge, male gender, blood glucose level, arterial fibrillation, dyslipidemia, smoking, NIHSS score, cardioembolic stroke type, and periventricular hyperintensities, but not FT4 or TSH, were significantly associated with poor functional outcome.27538607
Sleep Apnea, ObstructiveDeregulated Nutrient SensingIncreased resting energy expenditure and insulin resistance in male patients with moderate-to severe obstructive sleep apnoea.27539109
Hyalinosis, SystemicDeregulated Nutrient SensingCellular studies revealed concomitant activation of sirt1 and foxo3a in hAMSC after HFS treatment, which was associated with upregulation of p21 and downregulation of bax and p53.27539404
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur aim was to investigate the association between the macrophage-activation marker soluble CD163 (sCD163), adiponectin, C-reactive protein (CRP) and changes in glycaemia, insulin resistance and insulin secretion in individuals at high risk of type 2 diabetes mellitus.27541014
Hyperglycemia, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe brain's default mode network (DMN), having a high rate of basal energy metabolism, is vulnerable to altered glucose metabolism in type 2 diabetes mellitus (T2DM) due to insulin resistance and chronic hyperglycemia.27543086
Dyslipidemias, Hypertriglyceridemia, LeukopeniaDeregulated Nutrient SensingThe treatment-related grade 3 AE included hypertriglyceridemia (4/16 patients, 25%), increased alanine aminotransferase, increased aspartate aminotransferase, dyslipidaemia, leukopenia and neutropenia (1/16 patients, 6%), and one of 16 patients experienced grade 4 hypertriglyceridemia.27543197
Hypertension, CTCAE, ObesityDeregulated Nutrient SensingSevere/morbid obesity was associated with higher triglycerides, hs-CRP, insulin and insulin resistance, diastolic blood pressure and higher odds of hypertension than grade I obesity both in women and men (all, P<0.05).27543708
Diabetes Mellitus, Beta-cell dysfunctionDeregulated Nutrient SensingDiabetes was associated with known risk factors (i.e., age, sex, family history for diabetes and increased BMI) and both beta-cell dysfunction and insulin resistance were present.27546476
Carcinoma, Pancreatic DuctalDeregulated Nutrient SensingInsulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma.27552832
Aggressive behaviorDeregulated Nutrient SensingInsulin resistance is associated with the aggressiveness of PDAC.27552832
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdditionally, indexes of insulin resistance and insulin secretion showed the same gene-energy interaction as type 2 diabetes.27553771
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBDNF Val/Met and Met/Met variants (rs6265) decreases the risk for glucose intolerance and type 2 diabetes.27553771
Lipid Metabolism DisordersDeregulated Nutrient SensingSerum betatrophin concentrations were higher in T2DM and IGT, and were closely related to glucolipid disorder, insulin resistance, but not related to the first-phase of glucose-stimulated insulin secretion.27554132
Stomach CarcinomaDeregulated Nutrient SensingPreoperative carbohydrate loading, an important element of the ERAS protocol, has been shown to reduce insulin resistance, but its effects on clinical endpoints in gastric cancer surgery remain controversial.27554250
Hypertension, CTCAE, Comorbidity, Dyslipidemias, ObesityDeregulated Nutrient SensingCommon comorbidities included hypertension (76%), dyslipidemia (52%), and obesity (49%).27556897
Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingShelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.27559927
deficiency aspects, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is characterized by a relative insulin deficiency or insulin resistance.27560635
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingEfficient treatment and prevention of insulin resistance is essential to prevent future CHD events.27561896
Hypertension, CTCAE, Comorbidity, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus.27563668
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingNSTEMI and unspecified MI patients had significantly higher prevalence of comorbidities than STEMI patients, except for hypertension and dyslipidemia.27564212
Dyslipidemias, PDR geneDeregulated Nutrient SensingDyslipidemia increased the HR of developing NPDR but not PDR or DME.27564383
Diabetic Retinopathy, Hypertension, CTCAE, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingAdjustments were made for age, sex, body mass index, hypertension, dyslipidemia, stroke, glycated hemoglobin, current drinking, use of anti-hypertensive agent, use of insulin, use of oral anti-hyperglycemic agent, and diabetic retinopathy.27564779
Atherosclerosis, Sarcopenia, ObesityDeregulated Nutrient SensingIn addition, elevated PRAL scores were associated with high ASCVD risk independent of obesity, exercise, and insulin resistance, but not sarcopenia.27565571
ObesityDeregulated Nutrient SensingDiet-induced acid load was associated with increased risk of CVD, independent of obesity and insulin resistance.27565571
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus.27568669
DyslipidemiasDeregulated Nutrient SensingHence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients in Hospital Putrajaya, a tertiary endocrine centre in Malaysia.27568669
DyslipidemiasDeregulated Nutrient SensingThis was a cross sectional, retrospective study of 214 T2DM patients with dyslipidaemia who had visited the endocrine clinic between January 2009 and December 2012.27568669
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThis significant association between glycaemic status and dyslipidaemia emphasises the additional possible use of HbA1c as a biomarker for dyslipidaemia as well as a potential indirect predictor of cardiovascular disease (CVD) risk in T2DM patients.27568669
Inflammation, Cardiovascular Diseases, Dyslipidemias, Decreased renal function, HypophosphatemiaDeregulated Nutrient SensingIn addition to decreased renal function, dyslipidemia, inflammation, and continuing hypophosphatemia were also accompanied by decreased BMD as in cardiovascular disease in KTrs.27569941
Prostate Cancer Outcomes Study, Cardiovascular DiseasesDeregulated Nutrient SensingPCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age.27571188
Prostate Cancer Outcomes Study, DyslipidemiasDeregulated Nutrient SensingIndependently of the phenotype, young PCOS patients showed high IR and dyslipidemia.27571188
ObesityDeregulated Nutrient SensingAs adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used.27571249
ObesityDeregulated Nutrient SensingTherefore, metformin may be useful as an additional therapy in combination with lifestyle intervention in adolescents with obesity and insulin resistance.27571249
Malignant neoplasm of liver, Chronic liver disease, Lymphoproliferative Disorder of the SkinDeregulated Nutrient SensingInsulin resistance likely increases the risk of chronic liver disease (CLD) and liver cancer, but long-term prospective studies with measured fasting glucose and insulin are lacking.27574287
Malignant neoplasm of liver, Lymphoproliferative Disorder of the Skin, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, elevated fasting glucose and insulin and insulin resistance were independently associated with risk of liver cancer and CLD mortality, suggesting a potentially important etiologic role for insulin and glucose dysregulation even in the absence of diagnosed diabetes.27574287
Dyslipidemias, Hypopituitarism, ObesityDeregulated Nutrient SensingIn both sexes, the risks of central obesity and dyslipidemia were higher in the hypopituitary group than in the control group.27577046
Dyslipidemias, ObesityDeregulated Nutrient SensingWhen limited to patients with dyslipidemia, nonadherence was related to age (HR = 1.21, 95% CI = 1.07-1.38) and obesity (HR = 1.23, 95% CI = 1.02-1.49).27578113
Hypertension, CTCAE, Coronary Artery Disease, DyslipidemiasDeregulated Nutrient SensingAdverse events were seen more frequently in patients with history of hypertension, dyslipidemia and previous coronary artery disease.27587928
DyslipidemiasDeregulated Nutrient SensingAs a marker of dyslipidemia, the level of non-high-density lipoprotein cholesterol (non-HDL-C) was calculated by subtracting HDL-cholesterol from total cholesterol.27589412
DyslipidemiasDeregulated Nutrient SensingAn elevated non-HDL-C level was associated with increasing age, increasing BMI, and male gender, and use of inducers enhanced the risk of dyslipidemia.27589412
Dyslipidemias, ObesityDeregulated Nutrient SensingWhile CBZ and VPA are first-line AEDs, medication should be selected by considering risk factors for dyslipidemia, such as age gender, and obesity.27589412
InflammationDeregulated Nutrient SensingThese associations persisted in within-pair analysis for monozygotic twins for insulin resistance (P<0.01), inflammation (P=0.03), and blood pressure (P=0.04) suggesting independence from genetic confounding.27591698
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Failure (biologic function)Deregulated Nutrient SensingType 2 diabetes mellitus (T2D) is a chronic metabolic disease regarded as insulin resistance and progressive failure of b cells.27592478
DyslipidemiasDeregulated Nutrient SensingThis article reports prevalence of dyslipidemia in the North Indian state of Punjab as part of a large household Non Communicable Disease (NCD) Risk Factor Survey.27595388
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPresence of more than 2 morbidities, diabetes and hypertension were significantly associated with all types of dyslipidemia.27595388
Dyslipidemias, ObesityDeregulated Nutrient SensingCompared to the other groups, heavy smokers had significantly higher prevalence of dyslipidemia (83%), obesity (34%), and elevated glycemic biomarkers.27595637
PeriodontitisDeregulated Nutrient SensingSevere Periodontitis Is Associated with Insulin Resistance in Non-abdominal Obese Adults.27598510
PeriodontitisDeregulated Nutrient SensingWe hypothesized that insulin resistance, even with normal body weight (body mass index or waist circumference), can aggravate periodontitis severity.27598510
Periodontitis, Diabetes MellitusDeregulated Nutrient SensingWe investigated the associations between diabetes, insulin resistance, and severe periodontitis.27598510
Periodontitis, Obesity, AbdominalDeregulated Nutrient SensingSubjects with severe periodontitis had significantly higher prevalence of abdominal obesity, serum triglycerides, and insulin resistance (P values of .012, <.001, and .003, respectively).27598510
PeriodontitisDeregulated Nutrient SensingThe prevalence of severe periodontitis increased significantly with increasing insulin resistance (P for trend = .04) in nondiabetic individuals.27598510
PeriodontitisDeregulated Nutrient SensingNon-abdominally obese subjects with insulin resistance were more likely to have severe periodontitis.27598510
Obesity, Abdominal, Periodontal DiseasesDeregulated Nutrient SensingInsulin resistance can be considered an independent risk factor of periodontal disease in normal weight population defined by abdominal obesity.27598510
millicurie, Data types - AddressDeregulated Nutrient SensingThese results imply that in AD and MCI insulin resistance with increased plasma insulin and decreased FPIR may be associated with the development of AD and MCI, accompanied with milder influence of low adiponectin levels and atherogenic lipid profile.27599805
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingAlthough dyslipidemia is common in CKD patients, we found that significant changes in apolipoproteins were not strictly associated with changes in plasma lipid levels.27600335
Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney DiseasesDeregulated Nutrient SensingObesity has detrimental effects on various clinical parameters and conditions, resulting in increased risk of hypertension, dyslipidemia, type 2 diabetes mellitus, hyperuricemia, and chronic kidney disease.27600639
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic (H) vs non-Hispanic White (NHW) populations.27603898
ETV3 wt AlleleDeregulated Nutrient SensingsTfR levels could be spuriously elevated in subjects with insulin resistance and without association with the MetS or its components.27605239
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is present long before the onset of type 2 diabetes and results not only from inherited and lifestyle factors but also likely from environmental conditions.27605624
Chronic kidney disease stage 5, Dyslipidemias, Chronic Kidney Diseases, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is one of the cardiovascular risk factors responsible for cardiovascular disease and rapid progression of chronic kidney disease (CKD) to end stage renal disease.27605724
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingEarly detection and management of dyslipidaemia will reduce cardiovascular burden and retard progression of CKD.27605724
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingTo determine the prevalence and pattern of dyslipidaemia in pre-dialysis CKD patients in a tertiary hospital in southern Nigeria.27605724
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThe overall prevalence of dyslipidaemia in the CKD patients was 60% which was significantly higher than 39% in the control (p=0.002).27605724
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia was commoner in female CKD patients (p=0.02) and those who were >= 45years (p=0.94).27605724
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidaemia is common in pre-dialysis CKD especially in female and older patients.27605724
Refractory anemias, Carotid Atherosclerosis, DyslipidemiasDeregulated Nutrient SensingA multivariable analysis, adjusted for standard cardiovascular risk factors, was performed to evaluate the influence of PCSK9 on RA related dyslipidaemia and subclinical carotid atherosclerosis.27606890
Lichen Planus, Inflammation, DyslipidemiasDeregulated Nutrient SensingEpicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia.27609552
TG gene, DyslipidemiasDeregulated Nutrient SensingExon 3 methylation positively correlated with TG concentration (r=0.359, P=0.003) and with a lipoprotein profile associated with atherogenic dyslipidaemia.27613158
Hyperhomocysteinemia, Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, P mitrale (finding), Cerebrovascular accident, Hyperuricemia, ObesityDeregulated Nutrient SensingEmpty nest elderly showed no more risk for comorbidities such as general obesity, abdominal obesity, hyperuricemia, hyperhomocysteinemia, diabetes, dyslipidemia, left atrial enlargement (LAE), and stroke.27618905
DyslipidemiasDeregulated Nutrient SensingWe investigated to achieve accurate and up-to-date information on the prevalence of dyslipidemia and its associations with other lipid-related diseases in rural North China.27619340
DyslipidemiasDeregulated Nutrient SensingThe odds ratios between dyslipidemia types and lipid-related diseases were further analyzed by logistic regression.27619340
Demographics Domain, Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, HyperuricemiaDeregulated Nutrient SensingFor subjects with dyslipidemia, the risk for non-alcoholic fatty liver disease (NAFLD) was highest with a 3.3-fold over that of non-dyslipidmia (OR = 3.30, P < 0.001); followed by hyperuricemia and diabetes mellitus (DM), while with 2-fold increase (OR = 1.99, P < 0.001; OR = 1.92, P < 0.001); with only 1.5-fold risk for atherosclerosis (AS) (OR = 1.47, P < 0.001).27619340
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes.27619983
Arterial Stiffness, Hypertension, CTCAEDeregulated Nutrient SensingPharmacological activation of SIRT1 may be an effective therapeutic strategy for arterial stiffness and hypertension.27620389
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia and diabetes were also independent factors for SUA and CUA, respectively.27621185
Glucose Intolerance (disease)Deregulated Nutrient SensingAlthough the etiology of these complications is unclear, we propose that glucose intolerance may be a predisposing factor.27624504
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCirculating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans.27624997
Mice, Inbred NOD, CognitiveDeregulated Nutrient SensingThese data indicate that insulin resistance in non diabetic obese children is associated with both cognitive fatigue and reduced motivation/anhedonia and with alterations in tryptophan metabolism.27627133
FatigueDeregulated Nutrient SensingFurther investigations are needed to determine whether inflammation-induced alterations in tryptophan metabolism is directly or indirectly implicated in insulin resistance and related fatigue.27627133
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia in obese SCH women is not severe, but if untreated for many years, it may lead to atherosclerosis.27629733
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes, hypertension, and dyslipidemia were significantly higher in the very high risk group than in the low risk group.27629948
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe prevalence of diabetes and dyslipidemia were significantly higher in evacuees than in non-evacuees in only the low risk group.27629948
Adipose tissueDeregulated Nutrient SensingEndotrophin levels correlated with adipose tissue mass, insulin resistance and fatty liver index.27631136
Coronary Stenosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTriglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes.27633375
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is one of the most important contributing factors to cardiovascular disease.27633375
Coronary Stenosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis study aimed to investigate the association between coronary artery stenosis (CAS) and triglyceride glucose index (TyG index), a simple insulin resistance marker, in asymptomatic subjects with type 2 diabetes.27633375
DyslipidemiasDeregulated Nutrient SensingFor dyslipidemia, vitamin D deficiency has been associated with higher low density lipoprotein-cholesterol (LDL-C) in a number of studies, but with inconsistent results in clinical trials.27633775
Hyperglycemia, HypoglycemiaDeregulated Nutrient SensingType B insulin resistance syndrome is a rare disease that occurs due to the development of autoantibodies to the insulin receptor and can result in either severe insulin resistance and hyperglycemia or, conversely, hypoglycemia.27636019
Weight decreased, Diabetic KetoacidosisDeregulated Nutrient SensingA 39-year-old Nigerian woman presented with significant weight loss, severe diabetic ketoacidosis, and severe insulin resistance requiring massive doses of exogenous insulin.27636019
Lupus ErythematosusDeregulated Nutrient SensingShe was diagnosed with systemic lupus erythematosus and type B insulin resistance syndrome.27636019
Diabetic Ketoacidosis, Diabetes MellitusDeregulated Nutrient SensingWe report a case of severe type B insulin resistance syndrome complicated by severe diabetic ketoacidosis soon after the initial diagnosis of diabetes, despite large doses of exogenous insulin therapy.27636019
Malignant neoplasm of endometrium, NeoplasmsDeregulated Nutrient SensingOur study shows a marked loss of AMP-activated protein kinase (AMPK) phosphorylation and nuclear human Forkhead box O1 (FOXO1) protein in estrogen-dependent endometrial cancer (EC) tumors compared to normal control endometrium.27636742
Malignant neoplasm of endometriumDeregulated Nutrient SensingMetformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway.27636742
NeoplasmsDeregulated Nutrient SensingA xenograft mouse model further revealed that metformin suppressed HEC-1B tumor growth, accompanied by downregulated ki-67 and upregulated AMPK phosphorylation and nuclear FOXO1 protein.27636742
Rheumatoid FactorDeregulated Nutrient SensingImprovement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study.27638812
Refractory anemiasDeregulated Nutrient SensingTo determine the change in established biomarkers of cardiovascular (CV) risk, namely, total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDL-C), N-terminal pro-brain natriuretic peptide (NT-proBNP) and insulin resistance (IR) in patients with early RA treated with two different treat-to-target strategies.27638812
SLC25A20 geneDeregulated Nutrient SensingWaist circumference and insulin resistance were greatest in PE women with CAC.27639028
Dyslipidemias, Myocardial Infarction, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidaemia is the key risk factor for arthrosclerosis, leading to myocardial infarctions and strokes.27641514
NeuralgiaDeregulated Nutrient SensingAs compared to healthy volunteers, neuropathic pain patients exhibited an increased expression of miR-124a (2.5 +- 0.7, p < 0.05) and miR-155 (1.3 +- 0.3; p < 0.05) as well as a reduced expression of SIRT1 (0.5 +- 0.2; p < 0.01).27646435
Inflammation, NeuralgiaDeregulated Nutrient SensingOur findings suggest that in neuropathic pain, enhanced targeting of SIRT1 by miR-124a and miR-155 induces a bias of CD4(+) T cell differentiation towards Tregs, thereby limiting pain-evoking inflammation.27646435
Muscle, Smooth, VascularDeregulated Nutrient SensingSIRT1 in vascular smooth muscle cells was remarkably downregulated in the suprarenal aortas of aged mice, in which AAAs induced by angiotensin II infusion were significantly elevated.27650558
vascular inflammationsDeregulated Nutrient SensingMechanistically, the reduction of SIRT1 was shown to increase vascular cell senescence and upregulate p21 expression, as well as enhance vascular inflammation.27650558
Inflammation, Glucocorticoid deficiency with achalasia, Muscle, Smooth, VascularDeregulated Nutrient SensingThese findings provide evidence that SIRT1 reduction links vascular senescence and inflammation to AAAs and that SIRT1 in vascular smooth muscle cells provides a therapeutic target for the prevention of AAA formation.27650558
Inflammation, Aortic Aneurysm, AbdominalDeregulated Nutrient SensingAge-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm.27650558
PsoriasisDeregulated Nutrient SensingThe role of irisin in the relationship between psoriasis and insulin resistance.27652568
PsoriasisDeregulated Nutrient SensingWe aimed to elucidate the pathogenesis of insulin resistance in psoriasis patients by evaluating serum irisin levels and metabolic parameters associated with insulin resistance in patients with plaque-type psoriasis vulgaris.27652568
Malignant neoplasm of endometriumDeregulated Nutrient SensingInsulin-Like Growth Factor 1/Mammalian Target of Rapamycin and AMP-Activated Protein Kinase Signaling Involved in the Effects of Metformin in the Human Endometrial Cancer.27654259
Ketosis, Hyperglycemic Hyperosmolar Nonketotic Coma, Diabetes MellitusDeregulated Nutrient SensingType 2 and ketosis prone diabetes in the non-ketotic phase were comparable in terms of lipid profile, blood pressure, waist-to-hip ratio, BMI and fat mass, insulin secretion and insulin resistance indices.27657549
Tuberculosis, Noncommunicable Diseases, Dyslipidemias, HIV, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingThey may present some Non-communicable diseases (NCD), such as hypertension, diabetes mellitus, dyslipidemia and/or obesity and, predominantly present a great chance of being a carrier of the Human Immunodeficiency Virus, associated or not with tuberculosis.27659611
DyslipidemiasDeregulated Nutrient SensingA Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies.27660121
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 Diabetes (T2D) develops, when b-cell insulin response fails to compensate for insulin resistance.27664841
Units Of Measure - SiemensDeregulated Nutrient SensingMHO and MONW individuals were identified using fasting glucose, insulin resistance, blood pressure, triglycerides, C-reactive protein, and high-density lipoprotein-cholesterol.27665232
Inflammation, ObesityDeregulated Nutrient SensingDecreased blood concentration of Glu-OC may be a selective early symptom of insulin resistance in obesity, whereas the decreased level of Gla-OC seems to be associated with the appearance of early markers of low grade inflammation accompanying obesity.27667744
Glucose Intolerance (disease)Deregulated Nutrient SensingThese findings suggest that glucose intolerance in PA may be caused by hypokalemia-induced insulin resistance and hypokalemia-independent impairment of early-phase insulin secretion.27669369
Diastolic hypertensionDeregulated Nutrient SensingIn addition, BMI increases between 13-17 years and 17-21 years were associated with increases in systolic and diastolic blood pressure, and insulin resistance, but more strongly for the later period.27677621
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIt is well known that dyslipidemia is a subclinical manifestation of atherosclerosis.27678442
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingOveractivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia.27680666
Dyslipidemias, Blood GlucoseDeregulated Nutrient SensingOur findings in mice and humans suggested that decreased cav-1 expression may activate the effect of aldosterone/MR signaling on several pathways of glycemia, dyslipidemia, and resistin.27680666
Tortuosity, Dyslipidemias, CalcinosisDeregulated Nutrient SensingCalcification, age, PBR, dyslipidemia and tortuosity are other independent risk factors for PSR.27681252
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient Sensing60% of the patients presented hypertension, 57% dyslipidemia, 21% type 2 diabetes mellitus, 45% smoking, and 34.7% a previous MI.27681955
InflammationDeregulated Nutrient SensingFindings from animal studies have proposed underlying mechanisms including increased activation of the renin-angiotensin system, increased blood pressure, insulin resistance and chronic low-grade inflammation.27687738
Liver Dysfunction, Diabetes MellitusDeregulated Nutrient SensingIncidence of insulin resistance and diabetes in patients with portosystemic shunts without liver dysfunction.27688688
SCHISTOSOMIASIS CHRONIC HEPATIC, Diabetes MellitusDeregulated Nutrient SensingObjective To investigate the incidence of insulin resistance (IR) and diabetes in patients with chronic hepatic schistosomiasis japonica (HSJ) and portosystemic shunts (PSS).27688688
Peripheral Vascular Diseases, Alopecia, Alopecia, CTCAE, square decimeterDeregulated Nutrient SensingThis hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2.27692164
Primary malignant neoplasmDeregulated Nutrient SensingHere, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer metabolism in response to cetuximab treatment.27693630
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingWe found that introduction of experimental ACC mutants lacking the AMPK phosphorylation sites (ACC1_S79A and ACC2_S212A) into head and neck squamous cell carcinoma (HNSCC) cells protected HNSCC cells from cetuximab-induced growth inhibition.27693630
ACACA wt AlleleDeregulated Nutrient SensingHNSCC cells with acquired cetuximab resistance contained not only high levels of T172-phosphorylated AMPK and S79-phosphorylated ACC1 but also an increased level of total ACC.27693630
ACACA wt Allele, Primary malignant neoplasmDeregulated Nutrient SensingOur data suggest a novel paradigm in which cetuximab-mediated activation of AMPK and subsequent phosphorylation and inhibition of ACC is followed by a compensatory increase in total ACC, which rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent.27693630
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingDyslipidemia is often detected in patients with chronic kidney disease (CKD).27695128
Sleeplessness, Sleep Apnea, Obstructive, Hypertension, CTCAEDeregulated Nutrient SensingAn apnea- and hypoxia-independent effect of sleep fragmentation on sympathetic discharge during wakefulness could contribute to intersubject variability, age-related increases in muscle sympathetic nerve activity, associations between sleep deprivation and insulin resistance or insomnia and future cardiovascular events, and residual adrenergic risk with persistence of hypertension should therapy eliminate obstructive apneas but not arousals.27698070
ETV3 wt AlleleDeregulated Nutrient SensingIn addition, JAMRISC was useful not only as a MetS risk score test, but also as a screening tool for diagnosing insulin resistance.27699688
Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt AlleleDeregulated Nutrient SensingJAMRISC questionnaire is a useful instrument for the detection of early risk of not only MetS and type 2 diabetes but also insulin resistance.27699688
ObesityDeregulated Nutrient Sensinglower insulin resistance, lower C-reactive protein, lower degree of obesity and visceral fat rating (p < .05), despite the higher fat percentage (p < .05).27700189
Dyslipidemias, Alcoholic Intoxication, ChronicDeregulated Nutrient Sensingsmokers 59, 7%, alcoholism 19.5%, DM 10.9%, AHT: 53.6%, dyslipidemia 30.5%.27702437
TG gene, diabeticDeregulated Nutrient SensingThis observational retrospective study investigated whether diabetic dyslipidemia-that is, high triglyceride (TG) and/or low HDL cholesterol (HDL-C) levels-contributes to this high residual risk for DKD.27703024
cardiac muscle tissue growthDeregulated Nutrient SensingHere, we show that simultaneous inhibition of mTOR signaling to both S6K1 and 4E-BP1 is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin.27705797
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus.27709225
HyperglycemiaDeregulated Nutrient SensingFurthermore, we investigated the effects of the a-glucosidase inhibitor acarbose and the PPARg agonist rosiglitazone, targeting hyperglycaemia or insulin resistance, versus placebo, in 28 and 18 T2DM subjects, respectively.27709225
Endothelial dysfunctionDeregulated Nutrient SensingIn conclusion, resistin, antagonising insulin action in part through PPARg activation, may favour insulin resistance and enhance oxidative stress, endothelial dysfunction and platelet activation.27709225
Inflammation, ObesityDeregulated Nutrient SensingThe available literature suggests that circulating visfatin/Nicotinamide Phosphoribosyltransferase (NAMPT) level variability in humans is related to obesity, insulin resistance, inflammation, and lipid profile.27712122
Hyperlipidemia, Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingOne thousand adults with one or more qualifying changes in statin therapy and one or more previous diagnoses of hyperlipidemia, hypercholesterolemia, or mixed dyslipidemia were identified from the Henry Ford Health System administrative database.27712714
DyslipidemiasDeregulated Nutrient SensingWe aimed to elucidate their associations with current dyslipidemias, and identify their levels at increased risk to dyslipidemia.27713142
DyslipidemiasDeregulated Nutrient SensingThe substantial discordances with current dyslipidemias might provide novel view in lipid management and further cardiovascular benefit.27713142
Prediabetes syndrome, Blood GlucoseDeregulated Nutrient SensingThese findings support that consumption of IEB in prediabetic subjects produces a response that is dependent on BMI, with a clear improvement of insulin resistance and postprandial and nocturnal glycemia in non-obese subjects and a marked anti-inflammatory response in obese subjects.27713964
Impaired cognition, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction.27714551
HypoperfusionDeregulated Nutrient SensingCorrelation analyses revealed that in patients, hypoperfusion in PCC and precuneus regions were related to higher insulin resistance level and deficits in clock-drawing performance, while the occipital hypoperfusion was associated with worse visual-memory performance, regardless of PVEs correction.27714551
Presenile dementia, Iris hypoperfusionDeregulated Nutrient SensingThe cerebral hypoperfusion pattern in T2DM resembles the pattern observed in the early stage of dementia, and increased insulin resistance might be an important risk factor as well as treatment target for such CBF dysregulation.27714551
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women.27716220
Dyslipidemias, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingOur data indicate that the rs662799 polymorphism is associated with dyslipidemia and the severity of CHD in Chinese women.27716220
MVK gene, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingAssociation of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population.27716295
SarcopeniaDeregulated Nutrient SensingThe non-obese sarcopenia subgroup showed health problems related to insulin resistance and metabolic-related factors compared with the nonsarcopenic group.27717662
TG geneDeregulated Nutrient SensingSignificant reduction in fasting plasma glucose (FPG), insulin, insulin resistance (by HOMA-IR) and TG concentrations and an increase in HDL.C was seen over the 12 wk of study in each group (p < 0.001).27720403
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR), a risk factor for cardiovascular disease and all-cause mortality, is prevalent among maintenance hemodialysis patients.27721230
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCompounds in cocoa and chocolate have established cardiovascular benefits, including beneficial effects on insulin resistance, a risk factor for type 2 diabetes mellitus.27725277
Cerebrovascular accidentDeregulated Nutrient SensingHomeostatic model assessment for insulin resistance was associated with increased E/E' (P<0.001), and greater relative wall thickness and septal thickness (both P<0.05); lower stroke volume (P<0.0001); and lower peak lateral and septal E' velocities (both P<0.01).27729362
Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingGlucose intolerance and insulin resistance are associated with unfavorable cardiac structure and function, particularly worsened measures of diastolic function, even before the development of diabetes mellitus.27729362
Glucose Intolerance (disease), Cerebrovascular accidentDeregulated Nutrient SensingGlucose intolerance was associated with increased left ventricular posterior wall and interventricular septal and relative wall thicknesses (all P<0.05), reduced ejection fraction (P<0.01), reduced stroke and end-diastolic volumes (both P<0.001), decreased peak E' velocity (lateral and septal P<0.001), and increased E/E' ratio (lateral and septal P<0.01).27729362
Colon CarcinomaDeregulated Nutrient SensingWe aimed to determine mTOR activity-related proteins in clinically followed, conventionally treated colon carcinomas and to analyse the correlation between clinical data and mTORC1 and mTORC2 activity.27729429
NeoplasmsDeregulated Nutrient SensingThe presented staining panel could be appropriate and highly recommended for the accurate specification of mTORC1 and C2 activity of tumour tissues.27729429
Diabetes MellitusDeregulated Nutrient SensingIncreased urinary excretion of Cr was reported in subjects with diabetes compared with non-diabetic controls and those with non-diabetic insulin resistance.27731332
Dyslipidemias, Cerebral Atherosclerosis, diabeticDeregulated Nutrient SensingDyslipidemia occurring in diabetic patients, play a critical role in acceleration of macrovascular atherosclerosis and contribute to the excess risk of CVD.27731552
Prediabetes syndrome, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThese prediabetic individuals, because of their dyslipidemia, are at higher risk for developing cardiovascular disease.27731552
Diabetes MellitusDeregulated Nutrient SensingTo determine the associations of SHBG, T, and DHT with insulin resistance and incident diabetes in older adult men.27732332
Diabetes MellitusDeregulated Nutrient SensingAmong older men, higher levels of DHT were inversely associated with insulin resistance and risk of diabetes over the ensuing 10 years, whereas levels of T were not.27732332
Diabetes MellitusDeregulated Nutrient SensingIncreased consumption of high-fat diets is associated with the development of insulin resistance and type 2 diabetes.27733250
Weight decreased, diabeticDeregulated Nutrient SensingInclusion of WWCrB in the daily dietary pattern of diabetic patients resulted in improvement of glucose tolerance and insulin resistance, significant reduction in HbA1c, weight loss and lower SBP.27734127
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGlucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D).27736893
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingCAD patients were older and more likely to have diabetes, hypertension, dyslipidemia and chronic kidney disease.27737597
Diabetes MellitusDeregulated Nutrient SensingInsulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging.27737951
Diabetes MellitusDeregulated Nutrient SensingWhether individuals with insulin resistance (IR) but without criteria for diabetes exhibit reduced mitochondrial oxidative capacity is unclear; addressing this question could guide research for new therapeutics.27737951
Malignant neoplasm of endometriumDeregulated Nutrient SensingIn preclinical studies, metformin decreases endometrial cancer (EC) cell growth by activation of AMPK/mTOR inhibition.27745917
NeoplasmsDeregulated Nutrient SensingTumor samples were evaluated for changes in AMPK, PI3K/AKT pathway, proliferation, and apoptosis by immunohistochemistry.27745917
Degenerative polyarthritis, Hyperlipidemia, Hypertension, CTCAEDeregulated Nutrient SensingOther common comorbidities were hypertension (37.6%), osteoarthritis (31.4%), and hyperlipidaemia/dyslipidaemia (30.3%).27749234
Degenerative polyarthritisDeregulated Nutrient SensingEffects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice.27752896
Cartilage destruction, Degenerative polyarthritisDeregulated Nutrient SensingThe results showed clear knee joint cartilage destruction and degeneration in the SIRT1-/- osteoarthritis group.27752896
Degenerative polyarthritisDeregulated Nutrient SensingCompared with the SIRT1+/+ osteoarthritis group and SIRT1-/- control group, SIRT1 protein expression was not obviously changed in the SIRT1-/- osteoarthritis group (P>0.05), while the expression levels of the SREBP2, VEGF and HMGCR proteins were significantly increased (P<0.05) and the levels of AKT and type II collagen proteins were significantly decreased (P<0.05).27752896
Degenerative polyarthritis, Degenerative disorder of cartilageDeregulated Nutrient SensingSIRT1 gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT signalling pathway, suggesting that SIRT1 gene may play a protective role against osteoarthritis.27752896
Dyslipidemias, Chronic Lymphocytic LeukemiaDeregulated Nutrient SensingThe Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study.27754925
Dyslipidemias, Chronic Lymphocytic LeukemiaDeregulated Nutrient SensingWe demonstrate a higher prevalence of dyslipidemia preceding a diagnosis of CLL compared with control subjects, supporting preclinical data.27754925
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA retrospective cross-sectional cohort analysis of 51,879 elderly Medicare fee-for-service beneficiaries with diabetes and 129,762 beneficiaries with dyslipidemia living in 10 east coast states.27755393
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThese lipoprotein subfraction parameters had stronger associations with insulin resistance compared to conventional lipid profiles in the IFG and T2D groups.27756036
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia is initiated in an early stage of impaired glucose metabolism, when early intervention might be required.27756036
Diabetes MellitusDeregulated Nutrient SensingStatin therapy is associated with a slightly increased risk of developing diabetes mellitus and insulin resistance in patients without diabetes.27756478
Inflammation, SteatohepatitisDeregulated Nutrient SensingMES + HS treatment (when all three groups were combined), significantly improved visceral adiposity, glycemic control, insulin resistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to baseline.27759092
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDiabetes and dyslipidaemia were the major comorbidities reported in patients with uncontrolled and resistant hypertension.27759337
Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias, ComorbidityDeregulated Nutrient SensingHypertension (80.8%) was the most common comorbidity, and dyslipidemia (59.0%) and ischemic heart disease (21.3%) were also prevalent.27759630
Tumor necrosis, Rheumatoid ArthritisDeregulated Nutrient Sensing1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes.27763638
Diabetes Mellitus, Non-Insulin-Dependent, Necrosis with inflammationDeregulated Nutrient SensingIn a prospective study of patients with type 2 diabetes, we found diets high in protein (either animal or plant) significantly reduced liver fat independently of body weight, and reduced markers of insulin resistance and hepatic necroinflammation.27765690
Inflammation, ObesityDeregulated Nutrient SensingCeramides are molecular lipids implicated in apoptosis, inflammation, obesity, and insulin resistance.27765765
Hypertension, CTCAE, Demographics Domain, DyslipidemiasDeregulated Nutrient SensingSignificant association was found between CAD and risk factors like hypertension, DM, dyslipidemia, smoking, tobacco consumption, WHR and BMI.27766800
Lecithin Acyltransferase Deficiency, DyslipidemiasDeregulated Nutrient SensingThe diagnosis of familial LCAT deficiency was confirmed by clinical examination, characteristic dyslipidemia, undetectable LCAT levels in plasma and positive family history.27766813
ARCN1 gene, Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingSirtuin-1 (SIRT1) and SIRT6, NAD+-dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which is characterized by the accelerated ageing of the lung and associated with increased oxidative stress.27767101
ARCN1 gene, SimultaneousDeregulated Nutrient SensingHere, we show that oxidative stress (hydrogen peroxide) selectively elevates microRNA-34a (miR-34a) but not the related miR-34b/c, with concomitant reduction of SIRT1/-6 in bronchial epithelial cells (BEAS2B), which was also observed in peripheral lung samples from patients with COPD.27767101
ARCN1 geneDeregulated Nutrient SensingImportantly, miR-34a antagomirs increased SIRT1/-6 mRNA levels, whilst decreasing markers of cellular senescence in airway epithelial cells from COPD patients, suggesting that this process is reversible.27767101
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease.27768686
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingDiagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer.27768839
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingTherefore, the present study was designed to evaluate the prognostic and diagnostic value of SIRT1/BIRC6 expression in non-small cell lung cancer (NSCLC).27768839
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingThe data on the prognostic impact of SIRT1/BIRC6 in NSCLC were collected from September 11, 2006 to July 10, 2014.27768839
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingMRNA level of SIRT1 was upregulated in NSCLC tissues as compared to normal tissues (3.18 +- 0.77 vs. 1.27 +- 0.62; P = .001).27768839
Non-Small Cell Lung Carcinoma, NeoplasmsDeregulated Nutrient SensingSIRT1 and BIRC6 may be linked to tumor progression and could be useful for the treatment of NSCLC.27768839
Hyperglycemia, Impaired T cell function, Diabetes MellitusDeregulated Nutrient SensingHyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, b-cell dysfunction and long-term complications of diabetes.27769710
GDC Comorbidity Terminology, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHypertension was the most common comorbid condition with 60.8 % of patients followed by obesity and dyslipidaemia.27770227
Metabolic acidosis, Chronic Kidney DiseasesDeregulated Nutrient SensingCorrection of metabolic acidosis improves insulin resistance in chronic kidney disease.27770799
Chronic Kidney Diseases, diabeticDeregulated Nutrient SensingHowever, it is unknown whether these interventions reduce insulin resistance (IR) in diabetic patients with CKD.27770799
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingAlthough dyslipidemia increases the risk for ischemic stroke, previous studies reported conflicting data regarding the association between lipid levels and stroke severity and outcome.27771869
Inflammation, Breast CarcinomaDeregulated Nutrient SensingInsulin Resistance and Inflammation in Black Women with and without Breast Cancer: Cause for Concern.27773978
Inflammation, Breast Carcinoma, OverweightDeregulated Nutrient SensingWe compared insulin resistance, inflammation, and lipids in overweight and obese Black women with a history of breast cancer (n=19), age similar controls (n=25), and older controls (n=32).27773978
Inflammation, Breast CarcinomaDeregulated Nutrient SensingThese biomarkers of insulin resistance and inflammation may be associated with increased risk of breast cancer recurrence and require ongoing evaluation, especially given the relatively abnormal findings compared with the controls in this underserved group.27773978
Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingBRP4 was also found to participate in the occurrence of insulin resistance, which may indicate its role as a potential biomarker which identifies cases of insulin resistance of CHD patients and is worth further study.27775783
Progranulins, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingProgranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM).27776152
HypertriglyceridemiaDeregulated Nutrient SensingIn addition, the MUO group exhibited increased risks of hypertriglyceridemia (OR: 2.57, P = 0.001), insulin resistance (OR: 2.37, P = 0.001) and elevated C-reactive protein level (OR: 2.09, P = 0.003).27776717
Diabetes MellitusDeregulated Nutrient SensingAlso in morbidly obese the higher leptin level and leptin-to-adiponectin ratio and simultaneously lower concentration of leptin receptor are associated with leptin resistance, additionally in possible future risk of insulin resistance and diabetes type 2.27779476
Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIncreases in the amount of inducible nitric oxide synthase (iNOS) protein and abnormal production of nitric oxide (NO) in skeletal muscle have been suggested to be associated with peripheral insulin resistance in patients with type 2 diabetes mellitus (T2DM).27782779
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingTraditional risk factors for CO such as gender, dyslipidemia, hypertension and diabetes were associated with both measures.27783768
Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingSirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease.27784320
ARCN1 geneDeregulated Nutrient SensingCigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.27784320
ARCN1 geneDeregulated Nutrient SensingThe expression of CD31, CD34, Sirt1 mRNAs, and miR-126-3p decreased and that of miR-34a increased in moderate COPD compared with that in control smokers.27784320
ARCN1 geneDeregulated Nutrient SensingSirt1 expression in blood cells from patients with COPD could be a biomarker for disease stability in patients with moderate COPD.27784320
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRefractory MG patients have higher prevalence and poor control (HbA1C >8%) of diabetes mellitus and dyslipidemia probably due to increased steroid usage.27790079
Intervertebral Disc DegenerationDeregulated Nutrient SensingThe present study is a continuation and complement of our former in vivo study of Sirt1 and its role in puncture-induced rodent disc degeneration model.27792110
Intervertebral disc structureDeregulated Nutrient SensingSirt1 protein expression level decreased in the discs of high Pfirrmann grade and the score of histological morphology of human intervertebral disc is consistent with the Pfirrmann grade.27792110
Intervertebral Disc DegenerationDeregulated Nutrient SensingSirt1 is a protective mediator in IVD degeneration and the expression of Sirt1 decreases in degenerative disc.27792110
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, AsthmaDeregulated Nutrient SensingThe highest concordance was achieved for diabetes and three combined cardiovascular disorders, while it was substantial for dyslipidemia and hyperuricemia, and low for asthma.27792735
Papillary thyroid carcinomaDeregulated Nutrient SensingHypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.27793057
Malignant NeoplasmsDeregulated Nutrient SensingEpigenetic modification and dysregulation affecting the HIC1/SIRT1 axis is potentially important for the development of malignancies.27793057
Thyroid NeoplasmDeregulated Nutrient SensingCompared to normal thyroid tissue, thyroid tumors had lower expression of HIC1 and higher SIRT1 expression.27793057
Negative Regulation of Cell CycleDeregulated Nutrient SensingRestoration of HIC1 expression through an overexpression plasmid or 5-aza-dC treatment reduced SIRT1 expression and cell proliferation, and led to senescence, cell cycle arrest, and apoptosis.27793057
Papillary thyroid carcinomaDeregulated Nutrient SensingAberrant expression of HIC1/SIRT1 and hypermethylation of the HIC1 promoter may be critical for the development and progression of papillary thyroid cancer.27793057
Increased insulin level, Metabolic DiseasesDeregulated Nutrient SensingHyperinsulinemia is a hallmark of insulin resistance-associated metabolic disorders.27796268
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Cardiovascular DiseasesDeregulated Nutrient SensingPostprandial hyperinsulinemia, hyperglycemia, and insulin resistance increase the risk of type 2 diabetes (T2D) and cardiovascular disease mortality.27798656
ObesityDeregulated Nutrient SensingUrinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women.27801986
ObesityDeregulated Nutrient SensingThe prevalence of obesity has markedly increased and is closely related to insulin resistance.27801986
Complication Aspects, Prostate Cancer Outcomes Study, Dyslipidemias, ObesityDeregulated Nutrient SensingIn addition, associations of several metabolic complications like insulin resistance, obesity, dyslipidemia and psychological co-morbidities are well known in PCOS.27802175
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOne patient had diabetes, three had hypertension, 11 (55%) had dyslipidaemia and 16 (80%) were smokers.27805237
Multimorbidity, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension, diabetes and dyslipidaemia constituted the most prevalent multimorbidity pattern.27809772
Depression, CTCAEDeregulated Nutrient SensingThe association between insulin resistance and depression in the Korean general population.27810270
Depression, CTCAEDeregulated Nutrient SensingPrevious studies showed that the insulin resistance (IR) could be related to depression.27810270
ObesityDeregulated Nutrient SensingRecent studies have reported that zinc has been implicated in altered lipid markers, insulin resistance and some obesity markers.27814737
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension and dyslipidemia are important cardiovascular risk factors.27819152
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingIn this retrospective, multicenter study, we collected case report forms (CRFs) of hypertensive patients with concomitant dyslipidemia who were prescribed an ARB/statin regimen between 1 April 2014 and 31 March 2015 from 51 outpatient clinics.27819152
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingWe identified a strong correlation between medication adherence and BP or LDL-C target achievement in Korean patients with concomitant hypertension and dyslipidemia.27819152
Abnormal circulating valine concentration, HyperinsulinismDeregulated Nutrient SensingHyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children.27824069
Fatty Liver DiseaseDeregulated Nutrient SensingInsulin resistance and intestinal barrier function should be intensively controlled to prevent progression from NAFL to NASH.27826704
InfarctionDeregulated Nutrient SensingInsulin Resistance Is a Risk Factor for Silent Lacunar Infarction.27827330
Infarction, SHC2 geneDeregulated Nutrient SensingThis study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults.27827330
Dyslipidemias, ObesityDeregulated Nutrient SensingAssociations of daily sleep duration and dietary macronutrient consumption with obesity and dyslipidemia in Koreans: A cross-sectional study.27828860
Dyslipidemias, ObesityDeregulated Nutrient SensingDaily sleep duration is known to be associated with obesity and dyslipidemia.This study was performed to examine the interactions between daily sleep duration and the risks of obesity and dyslipidemia according to dietary macronutrient consumption in 14,680 Korean adults using the 5th Korean National Health and Nutrition Examination Survey.Sleep duration was inversely associated with body mass index (P < 0.001), waist circumference (P < 0.001), total cholesterol (P < 0.001), and low-density lipoprotein -cholesterol (P = 0.001).27828860
ObesityDeregulated Nutrient SensingHigh fat and low carbohydrate consumption were confirmed to be associated with the risk of obesity in the shortest sleep duration group (<=5 hours a day).These findings indicate that sleep duration was negatively associated with obesity and dyslipidemia-related indices in Korean adults.27828860
Hyperglycemia, Dyslipidemias, Overweight, Hypertension, CTCAEDeregulated Nutrient SensingCFA of MS showed that overweight, hyperglycemia, dyslipidemia, and hypertension clustered together under a single latent factor of MS.27831641
Tuberous SclerosisDeregulated Nutrient SensingInhibitors of mammalian target of rapamycin complex 1, such as sirolimus, effectively target skin lesions in tuberous sclerosis complex (TSC).27837201
Inflammation, Dental Plaque, AtherosclerosisDeregulated Nutrient SensingThe architectural transcription factor high-mobility-group AT-hook 1 (HMGA1) has been involved in atherosclerosis, plaque formation, inflammation, and in the pathogenesis of insulin resistance and T2DM.27839822
DyslipidemiasDeregulated Nutrient SensingIn addition to clinical and economical consequences, dyslipidemia may have a significant impact on patients' QOL.27842211
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingThe increasing frequency of cardiovascular disease (CVD) rests on the presence of major cardiovascular risk factors including dyslipidemia.27853034
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThis dyslipidemia is also a target for the prevention and treatment of many cardiovascular diseases.27853034
Dyslipidemias, Diabetic Neuropathies, Cerebrovascular accident, Coronary Artery Disease, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdjustment was made for age, body mass index, waist, duration of type 2 diabetes, current smoking, current drinking, hypertension, dyslipidemia, coronary artery disease, stroke, glycated hemoglobin and diabetic neuropathy.27853168
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingSelenium exposure can induce liver insulin resistance and increased liver triglyceride concentrations in animals, which may link to an increased risk of nonalcoholic fatty liver disease (NAFLD).27853246
LipolysisDeregulated Nutrient SensingRole of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.27858284
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCNR1 is upregulated in states of type 2 diabetes and insulin resistance.27858284
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPeripheral CNR1 could be an interesting drug target in type 2 diabetes and dyslipidemia.27858284
Primary malignant neoplasm, Atherosclerosis, Heart valve disease, Diabetes MellitusDeregulated Nutrient SensingCathepsin S (CS) was shown to play a key role in cancer progression, atherosclerosis, heart valve disease, insulin resistance and diabetes mellitus.27858577
Dyslipidemias, Congestive heart failureDeregulated Nutrient SensingPatients with HbA1c >=6.5% were older (70 [63-79] vs 66 [56-75], P < .001) and had a higher incidence of dyslipidemia (83.5% vs 57.0%, P < .001) and congestive heart failure (39.5% vs 27.8%, P = .01).27861432
Bone Diseases, Dyslipidemias, Chronic Kidney Diseases, AtherosclerosisDeregulated Nutrient SensingAtherosclerosis is often a complication of chronic kidney disease (CKD) because of dyslipidemia and CKD-mineral and bone disorder.27861640
Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis, Diabetes MellitusDeregulated Nutrient SensingTo investigate, in the Carotid Atherosclerosis: Metformin for Insulin Resistance (CAMERA) trial (NCT00723307), whether the influence of metformin on the glucagon-like peptide (GLP)-1 axis in individuals with and without type 2 diabetes (T2DM) is sustained and related to changes in glycaemia or weight, and to investigate basal and post-meal GLP-1 levels in patients with T2DM in the cross-sectional Diabetes Research on Patient Stratification (DIRECT) study.27862873
Steatohepatitis, Hypertriglyceridemia, Diabetes Mellitus, Lipodystrophy, LipolysisDeregulated Nutrient SensingThe homozygous null LIPE mutation could result in marked inhibition of lipolysis from some adipose tissue depots and thus may induce an extremely rare phenotype of MSL and partial lipodystrophy in adulthood associated with complications of insulin resistance, such as diabetes, hypertriglyceridemia and hepatic steatosis.27862896
Small cell carcinoma of lungDeregulated Nutrient SensingTaken together, our results suggest that SCLC patients with RICTOR amplification may constitute a clinically important subgroup because of their potential response to mTORC1/2 inhibitors.27863413
Osteoarthritis, KneeDeregulated Nutrient SensingThe expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity.27863529
Degenerative polyarthritisDeregulated Nutrient SensingThe expression of SIRT1 in articular cartilage is negatively associated with severity of knee OA, indicating that SIRT1 may act as a monitoring indicator for determining development and progression of knee OA.27863529
Dyslipidemias, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingWe previously reported the association between toothbrushing practices and diabetes mellitus (DM) and dyslipidemia (DL) in a cross-sectional study.27863909
Retinal Vein Occlusion, DyslipidemiasDeregulated Nutrient SensingRetinal oximetry during treatment of retinal vein occlusion by ranibizumab in patients with high blood pressure and dyslipidemia.27865689
Hypertensive disease, Dyslipidemias, EdemaDeregulated Nutrient SensingWe retrospectively reviewed the medical records of six patients with visual acuity (VA) reduced by macular edema (ME) secondary to RVO with HBP and dyslipidemia, who underwent intravitreal anti-VEGF injection between October 2014 and February 2015 in the department of ophthalmology of Francois-Quesnay Hospital at Mantes-la-Jolie (France).27865689
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingIn this study, retinal venous oxygen saturation in patients with RVO, HBP and dyslipidemia was partially normalized during intravitreal ranibizumab treatment.27865689
Blood GlucoseDeregulated Nutrient SensingA significant reduction in blood glucose, insulin resistance, lipid profile, and anthropometric parameters was observed.27865810
Dental PlaqueDeregulated Nutrient SensingInsulin resistance and circulating concentrations of TNF-a, IL-6, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A and urinary microalbumin decreased after empagliflozin treatment, and this significantly correlated with plaque size.27866224
Inflammation, AtherosclerosisDeregulated Nutrient SensingImprovements in inflammation and insulin resistance seem to be mechanisms involved in the mitigation of atherosclerosis by empagliflozin.27866224
Primary goutDeregulated Nutrient SensingEffects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout.27878622
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingThe aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population.27879312
DyslipidemiasDeregulated Nutrient SensingIn summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia.27879312
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension (42%) and dyslipidaemia (37%) were the most commonly reported comorbidities; 7% reported on diabetes and 23% of men ( vs. 17% of women) were smokers.27879413
Obesity, Abdominal, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAbdominal obesity (measured as waist circumference) was the most common cardiovascular risk factor (61.7%) followed by age (40.5%), dyslipidaemia (36.3%) and diabetes (34.3%).27884949
Non-alcoholic Fatty Liver Disease, OverweightDeregulated Nutrient SensingCirculating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects.27885258
Non-alcoholic Fatty Liver Disease, OverweightDeregulated Nutrient SensingElevated circulating periostin level was associated with an increased risk of having NAFLD and insulin resistance among overweight and obese individuals.27885258
ObesityDeregulated Nutrient SensingCreatine kinase (CK), the central regulatory enzyme of energy metabolism, is particularly high in type II skeletal muscle fibers, which are associated with insulin resistance and obesity.27894867
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe further found that the risk of CAD is greatly potentiated by several concomitant risk factors (smoking, diabetes, hypertension, dyslipidemia, and a family history of CAD).27895197
Uremia, Inflammation, Skeletal muscle structure, CachexiaDeregulated Nutrient SensingInflammation in skeletal muscle is implicated in the pathogenesis of insulin resistance and cachexia but why uremia up-regulates pro-inflammatory cytokines is unknown.27897392
ObesityDeregulated Nutrient SensingLipoprotein lipase (LPL) activity is considered the rate-limiting step of very-low-density-lipoprotein triglycerides (VLDL-TG) tissue storage, and has been suggested to relate to the development of obesity as well as insulin resistance and type 2 diabetes.27898284
AHSG protein, human, AtherosclerosisDeregulated Nutrient SensingFetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis.27899247
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMultivariate analysis demonstrated that in patients with T2DM the odds of PAD increased with long diabetes duration, smoking, presence of arterial hypertension and dyslipidemia, as well as with lower fetuin-A levels.27899247
Dyslipidemias, Demographics Domain, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingDiabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown.27899364
Diabetes MellitusDeregulated Nutrient SensingShort Adult Stature Predicts Impaired b-Cell Function, Insulin Resistance, Glycemia, and Type 2 Diabetes in Finnish Men.27906553
Primary malignant neoplasm, Hypertension, CTCAE, Non-Cancer Related Death, DyslipidemiasDeregulated Nutrient SensingHypertension, fasting glucose and dyslipidemia showed differential impacts on cancer and non-cancer death, and were significantly predictive for non-cancer death.27906989
Alzheimers Disease", Impaired cognition, Data types - Address, ObesityDeregulated Nutrient SensingObesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease (AD).27911319
Increased insulin levelDeregulated Nutrient SensingA 29-year-old woman developed an autoantibody to the insulin receptor (type B insulin resistance), causing extreme insulin resistance and hyperinsulinemia.27911591
Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingTreatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but improves dyslipidemia in type 2 diabetic patients with abdominal obesity: a randomized, double-blind, placebo-controlled trial.27913872
Obesity, Diabetes MellitusDeregulated Nutrient SensingInteraction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men: the Third National Health and Nutrition Examination Survey.27914732
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingWe examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US.27914732
Disease, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe independent variables were age, number of diseases and medications, diagnosis of hypertension, dyslipidemia and diabetes, and tabagism.27915426
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingOn the other hand, dyslipidemia is recognized as a prominent risk factor for cardiovascular disease.27919279
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial.27919453
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingNumerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D).27922820
Breast CarcinomaDeregulated Nutrient SensingEffect of aerobic exercise intervention on markers of insulin resistance in breast cancer women.27925359
Best Case Imputation TechniqueDeregulated Nutrient SensingA structured AEI may improve insulin, HOMA-IR index and body composition in non-obese BC survivors without insulin resistance.27925359
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance.27926472
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients of CAS with CAD showed higher prevalence of diabetes, hypertension, dyslipidemia, smoking and family history of CAD.27931555
Prediabetes syndromeDeregulated Nutrient SensingPrevious studies have shown an inconsistent relation between habitual beverage consumption and insulin resistance and prediabetes.27934644
Prediabetes syndromeDeregulated Nutrient SensingRegular SSB intake, but not diet soda intake, is associated with a greater increase in insulin resistance and a higher risk of developing prediabetes in a group of middle-aged adults.27934644
Cancer-related fatigue, Obesity, AbdominalDeregulated Nutrient SensingAbdominal obesity and low cardiorespiratory fitness (CRF) are associated with insulin resistance in older adults.27936206
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, hypertension, dyslipidemia, smoking as well as elevated homocysteine and HsCRP found as risk factors of PAD.27938397
InflammationDeregulated Nutrient SensingDisturbed sleep has been associated with increased insulin resistance and elevated inflammation.27938923
Depression, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe regression models showed that in women, higher sleep onset latency (SOL) was associated with higher insulin resistance after controlling for age, smoking, obesity, diabetes, depression, and inflammatory cytokines.27938923
Cerebrovascular Disorders, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine RegimenDeregulated Nutrient SensingAntiepileptic drugs (AEDs) may increase development of dyslipidemia and cerebrovascular disease (CVD).27939141
Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingCVD risk profile showed obesity of 18 patients (12%), current smoker of 30 patients (20%), hypertension of 75 patients (50%), diabetes mellitus of 32 patients (21%), dyslipidemia of 15 patients (10%), and atrial fibrillation of 63 patients (42%).27939141
Primary malignant neoplasm, Dyslipidemias, Breast CarcinomaDeregulated Nutrient SensingAlthough dyslipidemia has been documented to be associated with several types of cancer including breast cancer, it remains uncertainty the prognostic value of serum lipid in breast cancer.27939967
Diabetes MellitusDeregulated Nutrient SensingThe arginine vasopressin (AVP) system has been postulated to play a role in glucose homeostasis, insulin resistance, and diabetes mellitus in human and animal studies.27940301
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDecreased circulating BMP-9 levels in patients with Type 2 diabetes is a signature of insulin resistance.27940998
Diabetes MellitusDeregulated Nutrient SensingHowever, no report has demonstrated the relationship of circulating BMP-9 levels with insulin resistance (IR) or Type 2 diabetes mellitus (T2DM) in humans.27940998
Dysphonia, Dyslipidemias, Gait abnormality, Horner Syndrome, Cerebellar AtaxiaDeregulated Nutrient SensingRegarding the risk factors, dyslipidemia and smoking predominated in the studied group and the most common signs and symptoms were gait abnormalities, the ataxia of the limbs, dysphonia, and Horner syndrome.27974932
InflammationDeregulated Nutrient SensingInflammation might link microbial exposures to insulin resistance.27978598
ProteobacteriaDeregulated Nutrient SensingProteobacteria levels were associated with insulin resistance (p < 0.05).27978598
Inflammation, Proteobacteria, Actinobacteria phylumDeregulated Nutrient SensingInflammation explained 30-98% of the observed associations between levels of Actinobacteria, Proteobacteria or Firmicutes and insulin resistance (p-values < 0.05).27978598
Periodontitis, Prediabetes syndrome, SMYD1 geneDeregulated Nutrient SensingThis study suggests associations between pre-diabetes and insulin resistance with BOP and periodontitis.27978601
Cholelithiasis, Gaucher DiseaseDeregulated Nutrient SensingPatients with Gaucher disease type 1 (GD1) show an altered lipid profile and a certain degree of insulin resistance, which might contribute to cholelithiasis (CL) and could possibly be associated with ABCG5/ABCG8 gene variants.27981300
CD55 gene, PathogenesisDeregulated Nutrient SensingTotal serum cholesterol (TC) and LDL-C were higher in patients with CL than in those without; no obvious influence of insulin-resistance to lithogenesis was found.27981300
Toxic effectDeregulated Nutrient SensingIHTG accumulation is strongly associated with adipose tissue insulin resistance (IR), supporting the current theory of lipotoxicity as a driver of IHTG accumulation.27981615
Dyslipidemias, Weight decreased, Hypertension, CTCAEDeregulated Nutrient SensingUnivariate analysis found that older age, male gender, having hypertension, dyslipidemia, and insulin-treated type 2 diabetes were all factors associated with sustained weight loss.27989521
Units Of Measure - Siemens, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAEDeregulated Nutrient SensingWhile some obese children are metabolically healthy (MHO), some have additional health problems, such as hypertension, dyslipidemia, insulin resistance, and hepatosteatosis, which increase mortality and morbidity related to cardiovascular diseases (CVD) during adulthood.27992361
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingPatients without dyslipidemia, insulin resistance, hepatosteatosis, or hypertension were considered as MHO.27992361
GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingData regarding alterations of insulin resistance (IR) and ACS after prolonged follow-up are limited.27992961
Inflammation, HDL Phospholipid Measurement, ETV3 wt AlleleDeregulated Nutrient SensingLow HDL-P is independently associated with incident MetS after adjustment for traditional risk factors, lipid parameters, adiposity, inflammation, and markers of insulin resistance.27993539
Inflammation, DyslipidemiasDeregulated Nutrient SensingHigher than expected cardiovascular mortality in hemodialysis patients, has been attributed to dyslipidemia as well as inflammation.27994294
Bone Diseases, Inflammation, DyslipidemiasDeregulated Nutrient SensingIn high-flux membrane hemodialysis patients, we observed a significant relationship of b2M with dyslipidemia and mineral bone disorders, but there was no correlation with inflammation.27994294
Autophagic Cell DeathDeregulated Nutrient SensingCell viability, SIRT1 enzyme activity, cell cycle regulation, apoptosis, and autophagic cell death were measured.27994519
Hypertensive disease, Primary malignant neoplasmDeregulated Nutrient SensingThe aberrant glucose metabolism is one of the hallmarks of cancer cells, and as a branch of glucose metabolism, hexosamine biosynthesis pathway (HBP) has been reported to play a critical role in the insulin resistance and progression of cancer.27996048
Cardiovascular Diseases, Prostate Cancer Outcomes Study, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Polycystic Ovary SyndromeDeregulated Nutrient SensingAdolescents with polycystic ovary syndrome (PCOS) have atherogenic dyslipidemia and increased cardiovascular disease (CVD) risk, and this is exacerbated in obesity.27997268
MitochondriaDeregulated Nutrient SensingRepressed SIRT1/PGC-1a pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration.27998274
methyldopaDeregulated Nutrient SensingFurthermore, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), a regulator of mitochondrial biogenesis and function was repressed, and lower expression levels of NAD-dependent deacetylase sirtuin1 (SIRT1) were found in AMD RPE-iPSC-RPE and AMD Skin-iPSC-RPE as compared to normal RPE-iPSC-RPE.27998274
methyldopa, Neurodegenerative DisordersDeregulated Nutrient SensingOur studies suggest SIRT1/PGC-1a as underlying pathways contributing to AMD pathophysiology, and open new avenues for development of targeted drugs for treatment of this devastating neurodegenerative disease of the visual system.27998274
ObesityDeregulated Nutrient SensingAssociation of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes.27998387
Aggressive course, ObesityDeregulated Nutrient SensingObesity and age, key risk factors for aggressive prostate cancer, are associated with insulin resistance.27998647
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, EpilepsyDeregulated Nutrient SensingPeople with epilepsy had less hypertension (43.3% vs. 50.4%), less diabetes (15.8% vs. 19.2%), more dyslipidemia (40.2% vs. 34.6%) and lower cardiovascular risk than the general population (P < 0.01).28000339
Dyslipidemias, EpilepsyDeregulated Nutrient SensingPeople with epilepsy had more dyslipidemia, related to EIAEDs, and lower cardiovascular risk but still took more statins than the general population.28000339
Cardiovascular Diseases, Diabetic Nephropathy, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingStudy participants with type 2 diabetes mellitus (T2DM) only should have at least one other risk factor defined as hypertension, dyslipidaemia, smoking, or diabetic nephropathy, and/or they had a history of cardiovascular disease.28002198
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingShe also had high blood pressure, dyslipidemia, secondary diabetes mellitus.28002537
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingMean age was slightly higher (69+-6 vs 64+-12, p>0.2), and male gender tended to be less frequent (63 vs 79%) with DM than with nonDM; all subjects showed dyslipidemia, and almost all had arterial hypertension.28002752
Malignant tumor of colon, Adenoma, Fatty LiverDeregulated Nutrient SensingIn multivariate analyses adjusting for age, sex, body mass index, smoking habits, alcohol intake, regular exercise, aspirin and analgesics use, family history of colon cancer, education level, fatty liver, high-sensitivity C reactive protein, homeostasis model assessment of insulin resistance, total cholesterol, and triglyceride, an increase in ALT was positively associated with the prevalence of low-risk and high-risk adenoma (P for trend = 0.029 and 0.027, respectively).28002874
DyslipidemiasDeregulated Nutrient SensingThese findings suggest dyslipidemia might play a role in lower urinary tract symptoms progression.28004415
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a risk factor for cardiovascular disease, with elevated low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) recognized as risk factors for acute coronary events.28010729
Inflammation, Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingLow-grade chronic inflammation emerges as a potent driver of insulin resistance and glucose dysregulation in obesity and associated non-alcoholic fatty liver disease (NAFLD).28011892
Weight GainDeregulated Nutrient SensingIn contrast, adipose-specific, but not hepatocyte-specific deletion of Ifnar1 deteriorated metabolic dysregulation induced by a high-fat diet, indicated by increased weight gain, insulin resistance and an impaired glucose tolerance.28011892
Data types - AddressDeregulated Nutrient SensingConsistently with sirtuin 1 role in controlling acetylation status, we observed a substantial reduction of the acetylation on histone 3 lysine 9, associated with gene transcription in the AD twin.28017215
Adenocarcinoma of lung (disorder)Deregulated Nutrient SensingExpression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma.28025080
Sex CharacteristicsDeregulated Nutrient SensingSexual dimorphism in interleukin 17A and adipocytokines and their association with insulin resistance among obese adolescents in Yogyakarta, Indonesia.28027637
ObesityDeregulated Nutrient SensingPro-inflammatory cytokines interleukin 17A (IL-17), leptin, and adiponectin have been associated with obesity and insulin resistance.28027637
DyslipidemiasDeregulated Nutrient SensingCompared with group G and controls, group M subjects were older and had increased adiposity indices, dyslipidemia, insulin resistance and elevated transaminase levels (all p < 0.05).28027788
Dyslipidemias, Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingIt has been demonstrated that diabetic dyslipidaemia is the chief bridge between diabetes and incremental risk of cardiovascular disease in patients with diabetes.28027866
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe present study indicated that the changes of lipid profile in patients with T2D are characterised by abnormal distributions of lipoprotein subfractions apart from clinically atherogenic dyslipidaemia.28027866
Glucose Intolerance (disease), Pancreatic carcinoma, diabeticDeregulated Nutrient SensingWe conclude that GIP and PP plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls.28027898
Stomach CarcinomaDeregulated Nutrient SensingRapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition.28028034
Diabetes MellitusDeregulated Nutrient SensingThe transcriptional regulator peroxisome proliferator-activated receptor g coactivator 1a (PGC1a) coordinates the exercise-stimulated skeletal muscle fiber-type switch from glycolytic fast-twitch (type IIb) to oxidative slow-twitch (type I) and intermediate (type IIa) fibers, an effect reversed in insulin resistance and diabetes.28028076
Endometrial Hyperplasia, Malignant neoplasm of endometriumDeregulated Nutrient SensingProspective evaluation of abnormal glucose metabolism and insulin resistance in patients with atypical endometrial hyperplasia and endometrial cancer.28028620
Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Sarcopenia, ObesityDeregulated Nutrient SensingSarcopenia recognises insulin resistance and obesity as risk factors, and is frequently associated with cardiometabolic disorders, including non-alcoholic fatty liver disease (NAFLD).28028821
Periodontitis, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingCentral adiposity, dyslipidaemia and hypertension were not associated with periodontitis.28028834
AtherosclerosisDeregulated Nutrient SensingSirtuin 1 (Sirt1) plays an important role in vascular biology, and influences aspects of age-dependent atherosclerosis.28029409
Apolipoproteins BDeregulated Nutrient SensingLaboratory data analyzed were triglycerides, total cholesterol, HDL, VLDL, LDL, apolipoprotein A1, apolipoprotein B, lipoprotein (a), non-esterified fatty acids (NEFA), glucose, insulin, oxidative stress, C-reactive protein, and Sirt1.28029409
OverweightDeregulated Nutrient SensingSerum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial.28029409
Amyotrophic Lateral Sclerosis, DyslipidemiasDeregulated Nutrient SensingThe percentage of individuals who had never smoked was greater for the ALS cohort (55.8%, P <= 0.001), and the prevalence of dyslipidemia was lower (38.7%) compared with the general population (74.4%, P < 0.001).28029705
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe majority of the patients were male with a medical history of hypertension, dyslipidaemia and previous coronary interventions.28031245
DamageDeregulated Nutrient SensingYounger male patients with insulin resistance or organ damage have a higher risk of presenting with FLI-NAFLD at baseline, developing FLI-NAFLD within 3 years, and a lower probability of regression.28032449
deficiency aspectsDeregulated Nutrient SensingMetS+/DM+ patients have the lowest levels of MEEi, consistent with the alterations of energy supply associated with the combination of insulin resistance with insulin deficiency.28032631
Prostate Cancer Outcomes Study, Irregular Menstruation, Hirsutism, Endocrine System Diseases, Hyperandrogenism, Polycystic Ovary SyndromeDeregulated Nutrient SensingPolycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance.28034591
Alzheimers Disease", Toxic effectDeregulated Nutrient SensingmTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-b Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.28035937
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingMammalian target of rapamycin complex 1 (mTORC1), a nutrient sensor and central controller of cell growth and proliferation, is altered in various models of Alzheimer's disease (AD).28035937
Data types - AddressDeregulated Nutrient SensingIn two rodent AD models, mTORC1 and C2 activities were also decreased.28035937
Data types - AddressDeregulated Nutrient SensingIn a neuronal culture model of AD characterized by accumulation of cellular amyloid-b (Ab)42, mTORC1 activity was reduced.28035937
Data types - AddressDeregulated Nutrient SensingWe conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD.28035937
Data types - AddressDeregulated Nutrient SensingEven less studied or understood in AD is mammalian target of rapamycin complex 2 (mTORC2) that influences cellular metabolism, in part through the regulations of Akt/PKB and SGK.28035937
Inflammation, Precocious atherosclerosis, Dyslipidemias, Sample Size Calculation, ObesityDeregulated Nutrient SensingOur findings confirm the presence of premature atherosclerosis in SSc patients assessed by significant impairment of FMD, flow change and ccIMT, and it is associated with traditional cardiovascular risk factors such as age, dyslipidemia and obesity (BMI) as well as with the use of steroids and markers of inflammation such as CRP and ESR.28036158
DyslipidemiasDeregulated Nutrient SensingPresence of CAD significantly correlated with dyslipidemia (p=0.047), history of smoking (p=0.025), and family history of CAD (p=0.002).28038720
Dyslipidemias, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes MellitusDeregulated Nutrient SensingIn the last two decades, studies have suggested that low testosterone levels are associated with increased prevalence of risk factors for cardiovascular disease (CVD), including dyslipidemia and diabetes.28038719
Glucose Intolerance (disease), HypertriglyceridemiaDeregulated Nutrient SensingCompared with a random sample of matched population controls, HCT survivors had an increased prevalence of hypertriglyceridemia and low HDL, but not of glucose intolerance, elevated blood pressure, or CVRF cluster.28040534
Endothelial dysfunctionDeregulated Nutrient SensingSirtuin 1 (SIRT1) appears to play a protective role against endothelial dysfunction and oxidative stress.28043667
Hypertension, CTCAEDeregulated Nutrient SensingSIRT1 levels correlated marginally with a history of hypertension (r=0.2, p=0.084) and inversely with baseline urea (r=0.25, p=0.056).28043667
square decimeter, Diabetes MellitusDeregulated Nutrient SensingWhen performing additional adjustment, low SIRT1 levels were independently associated with diabetes mellitus 2(DM2) and subjects with SIRT1 <2.95ng/mL were more prone to present DM2 (82% sensitivity and 62% specificity).28043667
Atrial Fibrillation, Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingThe index of low SIRT1 and high MMP2 respectively correlated with patients history of MI (r=0.3, p=0.01) and marginally with presence or history of atrial fibrillation (AF) (r=0.213, p=0.076).28043667
Coronary Artery DiseaseDeregulated Nutrient SensingThe combined index of low SIRT1 and high MMP2 exhibited a significant correlation with history of MI and EF, promoting a potential prognostic tool for MI incidence in patients regardless their coronary artery disease status.28043667
Electrocardiogram: myocardial infarction (finding), Coronary Artery DiseaseDeregulated Nutrient SensingA sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease.28043667
Overweight, Diabetes MellitusDeregulated Nutrient SensingAssociations among Insulin Resistance, Triacylglycerol/High Density Lipoprotein (TAG/HDL ratio) and Thyroid hormone levels-A study on Type 2 diabetes mellitus in obese and overweight subjects.28043815
ComorbidityDeregulated Nutrient SensingIn addition to insulin resistance, results of our study were focussed on thyroid comorbidity.28043815
OverweightDeregulated Nutrient SensingIn overweight diabetic patients, the ROC curve analyses demonstrated that the best marker for insulin resistance was Triacylglycerol/High density lipoprotein (TAG/HDL), with the area under the ROC curve being 0.902.28043815
Diabetes Mellitus, Non-Insulin-Dependent, OverweightDeregulated Nutrient SensingIn overweight type 2 diabetics, TAG/HDL ratio could be used as a reliable marker for insulin resistance with thyroid co-morbidity and T3, T4 were better objective markers in obese type 2 diabetics.28043815
Degenerative polyarthritisDeregulated Nutrient SensingmTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis.28043938
Degenerative polyarthritisDeregulated Nutrient SensingDisruption of mechanistic target of rapamycin complex 1 (mTORC1) promotes chondrocyte autophagy and survival, and decreases the severity of experimental OA.28043938
Degenerative polyarthritisDeregulated Nutrient SensingHowever, the role of cartilage mTORC1 activation in OA initiation is unknown.28043938
Degenerative polyarthritisDeregulated Nutrient SensingIn this study, we elucidated the specific role of mTORC1 activation in OA initiation, and identify the underlying mechanisms.28043938
Degenerative polyarthritisDeregulated Nutrient SensingExpression of mTORC1 in articular cartilage of OA patients and OA mice was assessed by immunostaining.28043938
Tuberous SclerosisDeregulated Nutrient SensingCartilage-specific tuberous sclerosis complex 1 (Tsc1, mTORC1 upstream inhibitor) knockout (TSC1CKO) and inducible Tsc1 KO (TSC1CKOER) mice were generated.28043938
Degenerative polyarthritisDeregulated Nutrient SensingThe functional effects of mTORC1 in OA initiation and development on its downstream targets were examined by immunostaining, western blotting and qPCR.28043938
Degenerative polyarthritisDeregulated Nutrient SensingArticular chondrocyte mTORC1 was activated in early-stage OA and in aged mice.28043938
Degenerative polyarthritisDeregulated Nutrient SensingmTORC1 activation stimulates articular chondrocyte proliferation and differentiation to initiate OA, in part by downregulating FGFR3 and PPR.28043938
Communicable Diseases, Helicobacter pylori, Metabolic Syndrome X, Chronic Kidney DiseasesDeregulated Nutrient SensingSome studies have suggested that Helicobacter pylori (H. Pylori) infection was associated with insulin resistance and metabolic syndrome, which may increase the risk of chronic kidney disease (CKD).28044235
DyslipidemiasDeregulated Nutrient SensingMajor risk factors were smoking (19.6%), dyslipidemia (48.8%), and CVD (41%).28045952
Postoperative cognitive dysfunctionDeregulated Nutrient SensingInsulin resistance plays a potential role in postoperative cognitive dysfunction in patients following cardiac valve surgery.28048971
Alzheimers DiseaseDeregulated Nutrient SensingSevere insulin resistance (IR) promotes the development of Alzheimer disease.28048971
Carotid Atherosclerosis, DyslipidemiasDeregulated Nutrient SensingHigh baPWV was a stronger predictor of early carotid atherosclerosis than high BP, dyslipidemia, or IFG in a Japanese general male population.28049936
Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingInsulin resistance represents one of the mechanisms underlying the link between type 2 diabetes (T2D) and Alzheimer's disease (AD), and we explored its in vivo neurobiology related to cognition based on a pathway-based genetic association analyses.28050343
Impaired cognitionDeregulated Nutrient SensingEighty-seven mild cognitive impairment (MCIs) subjects and 135 matched controls (HCs) were employed at baseline, and they underwent functional MRI scans, clinical evaluations and exon sequencings of 20 genes related to brain insulin resistance.28050343
Pancreatic carcinomaDeregulated Nutrient SensingmiR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.28052003
Pancreatic carcinomaDeregulated Nutrient SensingThese results indicate that miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1.28052003
Stomach CarcinomaDeregulated Nutrient SensingThe mechanisms underlying RORa reduction is due to the reduced activation of AMP-activated protein kinase (AMPK), as a selective AMPK activator AICAR increased RORa activation and level in human gastric cancer cells.28052040
Stomach Carcinoma, NeoplasmsDeregulated Nutrient SensingTaken together, RORa reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMPK.28052040
Stomach CarcinomaDeregulated Nutrient SensingTherefore, both RORa and AMPK are potential targets for the intervention and therapy in gastric carcinoma.28052040
DyslipidemiasDeregulated Nutrient SensingTherefore, non-HDL-C may be a more suitable target of dyslipidemia treatment than LDL-C in patients after AMI.28056802
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe efficacy and safety of co-administration of fimasartan and rosuvastatin to patients with hypertension and dyslipidemia.28057081
Hypertension, CTCAE, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingHypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events.28057081
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation between thyroid hormone parameters and dyslipidemia among type 2 diabetes mellitus patients: Comparative cross-sectional study.28057507
DyslipidemiasDeregulated Nutrient SensingThe aim of the current study was to assess the association between thyroid hormone parameters and dyslipidemia in T2DM and non-diabetic study participants.28057507
Dyslipidemias, Lung diseases, Hypertension, CTCAEDeregulated Nutrient SensingThe type (dyslipidemia, hypertension, pulmonary disease) and the number of comorbidities influenced the choice towards ABA (p = 0.01).28058538
Refractory anemias, Dyslipidemias, Lung diseasesDeregulated Nutrient SensingMultinomial logistic regression demonstrated that a second-line treatment, higher age, dyslipidemia, pulmonary disease, other comorbidities, and extra-articular RA manifestations were associated with ABA compared to TNFi.28058538
OverweightDeregulated Nutrient SensingTriglyceride to HDL-C Ratio is Associated with Insulin Resistance in Overweight and Obese Children.28059134
TG gene, OverweightDeregulated Nutrient SensingThe purpose of this study was to investigate the usefulness of triglyceride to hdl-c ratio (TG:HDL-C) as an insulin resistance (IR) marker for overweight and obese children.28059134
Stomach CarcinomaDeregulated Nutrient SensingCo-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.28061480
Stomach CarcinomaDeregulated Nutrient SensingTowards this, we used patient tissues representing different stages of gastric cancer including gastric pre-cancerous lesions, early gastric cancer, and advanced gastric cancer, and probed SIRT1, STAT3 and phosphorylated STAT3 (pSTAT3) levels using immunohistochemistry.28061480
Gastric mucosa, Stomach Neoplasms, Stomach CarcinomaDeregulated Nutrient SensingOur results revealed upregulated expression of SIRT1 in all stages of gastric cancer compared with noncancerous gastric mucosa, suggesting that high SIRT1 levels are likely involved in establishing gastric neoplasticity.28061480
Stomach CarcinomaDeregulated Nutrient SensingMoreover, co-ordinated high expression of SIRT1 and STAT3 predicted poor overall survival for advanced gastric cancer patients.28061480
Stomach CarcinomaDeregulated Nutrient SensingWe postulate that SIRT1 and STAT3 are potential early diagnostic and prognostic markers of gastric cancer.28061480
Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive disease, Prediabetes syndromeDeregulated Nutrient SensingIndividuals with IFG (prediabetes) and diabetes were merged each for positive cases of dyslipidaemia, high blood pressure (HBP) or obesity.28061844
Diabetic Retinopathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Macular edema due to diabetes mellitusDeregulated Nutrient SensingTo investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes.28061854
Malignant neoplasm of endometriumDeregulated Nutrient SensingWomen receiving multiple types of medications over a long time had the highest risk, implying that the extent of insulin resistance, rather than the effect of any specific medication, drives endometrial cancer risk.28062022
Steatohepatitis, Fibrosis AssessmentDeregulated Nutrient SensingThe associations of breath 13CO2 levels with hepatic steatosis, fibrosis and insulin resistance was evaluated using laboratory data, elastography results and liver histology findings.28062946
Steatohepatitis, Fibrosis AssessmentDeregulated Nutrient SensingThe 13CO2 excretion of e-NASH patients was significantly correlated with the degree of hepatic steatosis, fibrosis and insulin resistance (P = 0.005, P < 0.001, P = 0.019, respectively).28062946
Hyperglycemia, Pancreatitis, LipolysisDeregulated Nutrient SensingOverall, patients with chronic hyperglycemia after acute pancreatitis appear to have a lipid profile indicative of an up-regulation of lipolysis, which is not significantly affected by either general or adipose tissue-specific insulin resistance.28065464
Pancreatitis, DyslipidemiasDeregulated Nutrient SensingThe importance of dyslipidemia is well recognized in the context of both risk factor for acute pancreatitis and prognostic factor for its in-hospital outcomes.28065464
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingMost people with hypertension received specific drug treatment but only half of them reached target values; dyslipidemia treatment showed similar data.28065677
Dyslipidemias, diabeticDeregulated Nutrient SensingTo find the risk of dyslipidaemia in diabetic patients of different age groups.28065951
Stomach CarcinomaDeregulated Nutrient SensingThe Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer.28070138
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDyslipidaemia plays a key role in the pathogenesis of type 2 diabetes.28070639
Diabetes MellitusDeregulated Nutrient SensingObjectives: Omentin-1, an adipocytokine that increases the insulin sensitivity, has been determined to be reduced in patients with insulin resistance, impaired glucose tolerance, and Type-2 diabetes mellitus.28073124
Hypertensive (finding)Deregulated Nutrient SensingTestosterone Plasma Concentration is Associated with Insulin Resistance in Male Hypertensive Patients.28073130
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBackground: Low testosterone levels are a common finding among men with Type 2 Diabetes Mellitus (T2DM) and are inversely related to insulin resistance.28073130
Rheumatoid Arthritis, DyslipidemiasDeregulated Nutrient SensingManagement of dyslipidaemia in high-risk patients with recent-onset rheumatoid arthritis: targets still not met despite specific recommendations.28079508
Refractory anemias, DyslipidemiasDeregulated Nutrient SensingSpecific recommendations for RA published in 2006 decreased LDLc target but did not improve management of dyslipidaemia in daily life which remained suboptimal particularly in patients at highest risk.28079508
Chronic Kidney DiseasesDeregulated Nutrient SensingBoth MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population.28081778
Connective Tissue DiseasesDeregulated Nutrient SensingSuccessful treatment of type B insulin resistance with mixed connective tissue disease by pulse glucocorticoids and cyclophosphamide.28084020
LipodystrophyDeregulated Nutrient SensingGlucagon-like peptide-1 analogues - an efficient therapeutic option for the severe insulin resistance of lipodystrophic syndromes: two case reports.28086952
Diabetes MellitusDeregulated Nutrient SensingThese complications are generally difficult to treat, particularly diabetes, due to severe insulin resistance.28086952
Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Lipodystrophy, Fatty Liver DiseaseDeregulated Nutrient SensingLipodystrophic syndromes are uncommon medical conditions which are normally associated with metabolic disorders, such as diabetes mellitus, dyslipidemia, and fatty liver disease.28086952
Dyslipidemias, Cerebrovascular accident, Chronic lung disease, Peripheral Vascular Diseases, Hypertension, CTCAEDeregulated Nutrient SensingIncreasing age was associated with more comorbidities (dyslipidemia, hypertension, prior coronary artery bypass graft surgery, prior stroke, peripheral arterial disease, and chronic lung disease) and more lesion calcification.28089997
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo determine whether sclerostin is associated with fasting glucose, insulin levels, insulin resistance or increased risk of incident type 2 diabetes.28090669
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOmentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors.28091434
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingRisk of hypertension, dyslipidemia, and overweight/obesity in initially underweight Soldiers was 40%, 31%, and 79% lower, respectively, versus normal-weight Soldiers.28095509
Lewy Bodies, Dopaminergic NeuronsDeregulated Nutrient SensingHere we show that a-synuclein binds phosphoinositide-3 kinase enhancer L (PIKE-L) in a phosphorylation-dependent manner and sequesters it in Lewy bodies, leading to dopaminergic cell death via AMP-activated protein kinase (AMPK) hyperactivation.28096359
Dopaminergic NeuronsDeregulated Nutrient Sensinga-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.28096359
Synucleinopathies, neuron deathDeregulated Nutrient SensingHence, our findings demonstrate that a-synuclein neutralizes PIKE-L's neuroprotective actions in synucleinopathies, triggering dopaminergic neuronal death by hyperactivating AMPK.28096359
Chronic Kidney DiseasesDeregulated Nutrient SensingInsulin resistance in predialytic, nondiabetic, chronic kidney disease patients: A hospital-based study in Eastern Uttar Pradesh, India.28098101
Chronic Kidney DiseasesDeregulated Nutrient SensingThe objective of this study was to examine the degree and determinants of insulin resistance (IR) in predialytic, nondiabetic, CKD patients.28098101
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSeventeen patients had dyslipidemia when diabetes was discovered.28099349
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOf 13 patients who had received either oral hypoglycemic drugs or insulin, 2 patients achieved well-controlled hemoglobin A1c without hypoglycemic drugs, and 10 patients had hemoglobin A1c 5.0% to 7.7% with the continued use of hypoglycemic drugs.We demonstrated that almost all patients who developed quetiapine-associated diabetes had dyslipidemia and increased BMI.28099349
Endothelial dysfunctionDeregulated Nutrient SensingExposure to bisphenols and phthalates and association with oxidant stress, insulin resistance, and endothelial dysfunction in children.28099427
AlbuminuriaDeregulated Nutrient SensingExposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children.28099427
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe ASA group was older, had higher frequency of dyslipidemia and hypertension, and lower renal function than the non-ASA group.28100879
Alzheimers Disease", AtrophicDeregulated Nutrient SensingExosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease.28105773
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingBrain insulin resistance (IR), which depends on insulin-receptor-substrate-1 (IRS-1) phosphorylation, is characteristic of Alzheimer's disease (AD).28105773
Dyslipidemias, Snoring, ObesityDeregulated Nutrient SensingSelf-Reported Snoring Is Associated with Dyslipidemia, High Total Cholesterol, and High Low-Density Lipoprotein Cholesterol in Obesity: A Cross-Sectional Study from a Rural Area of China.28106727
CD55 gene, Dyslipidemias, SnoringDeregulated Nutrient SensingStudies to explore the relationship between self-reported snoring and dyslipidemia, especially high total cholesterol (TC) and high low-density lipoprotein cholesterol (LDL-C), in the general population are still lacking.28106727
Dyslipidemias, SnoringDeregulated Nutrient SensingAfter adjustment for all confounding factors, self-reported snoring (OR = 1.207; p = 0.003), moderate (OR = 1.229; p = 0.015), strong (OR = 1.222; p = 0.033), and very strong (OR = 1.467; p = 0.012) snoring intensity, but not low (OR = 1.110; p = 0.224) snoring intensity, were significantly associated with dyslipidemia among adults with BMI (body mass index) >= 25 kg/m2.28106727
Dyslipidemias, SnoringDeregulated Nutrient SensingIn conclusion, adults with BMI >= 25 kg/m2 and who experience snoring, especially moderate, strong, and very strong intensity levels of snoring, should be on the alert regarding the possibility of dyslipidemia, especially high LDL-C and high TC.28106727
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCognitive function and insulin resistance in elderly patients with type 2 diabetes.28107806
Impaired cognition, Diabetes MellitusDeregulated Nutrient SensingTo explore the relationship between cognitive impairment and insulin resistance (IR) in elderly patients with type-2 diabetes mellitus.28107806
Prediabetes syndrome, Cerebrovascular accidentDeregulated Nutrient SensingPost-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke.28108466
Ischemic strokeDeregulated Nutrient SensingThis study aimed to estimate the association between post-glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke.28108466
Ischemic strokeDeregulated Nutrient SensingIn this large-scale registry, post-glucose load measures of insulin resistance with the ISI(composite) and the ISI0,120 were associated with 12-month poor outcomes of nondiabetic patients with ischemic stroke.28108466
ObesityDeregulated Nutrient SensingWe identified an association between SIRT1 variation and pediatric obesity in Korean children with a gender difference.28118644
Tumor necrosisDeregulated Nutrient SensingLoss of LKB1 was associated with reduced AMPK activation in PDXs and increased tumor necrosis following bevacizumab administration, highlighting impaired control of the metabolic stress caused by this antiangiogenic drug.Conclusions: Our data hint at a possible predictive impact of LKB1 expression in patients with aNSCLC treated with chemotherapy plus bevacizumab.28119362
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingManagement Status of Cardiovascular Disease Risk Factors for Dyslipidemia among Korean Adults.28120563
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia, hypertension, and diabetes are well-established risk factors for cardiovascular disease (CVD).28120563
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe age-standardized prevalence was highest for dyslipidemia (39.6%), followed by hypertension (32.8%) and diabetes (9.8%).28120563
DyslipidemiasDeregulated Nutrient SensingThe lowest patient awareness was found for dyslipidemia (27.9%).28120563
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe treatment rate was 66.5% for diabetes and 57.3% for hypertension, but only 15.7% for dyslipidemia.28120563
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe control rate among those undergoing treatment was highest for hypertension (64.2%), followed by dyslipidemia (59.2%) and diabetes (22.1%).28120563
DyslipidemiasDeregulated Nutrient SensingThe higher the risk levels of CVD were, the lower the control rate of dyslipidemia.28120563
DyslipidemiasDeregulated Nutrient SensingHigher CVD-risk categories showed lower control rates of dyslipidemia.28120563
PGLS geneDeregulated Nutrient SensingTotal mTOR, p-S6K and p-S6, and mTORC1-associated molecules p-Raptor and p-AMPK were all significantly overexpressed in PGLs rather than in PCCs, and in the head and neck rather than in abdominal locations.28122379
ParagangliomaDeregulated Nutrient SensingThe mTORC1 Complex Is Significantly Overactivated in SDHX-Mutated Paragangliomas.28122379
NeoplasmsDeregulated Nutrient SensingWithin cluster 1, molecules active in the mTORC1 complex were significantly overexpressed in SDHX- as compared to VHL-mutated tumors.28122379
Dyslipidemias, Coronary heart disease, Cerebrovascular accidentDeregulated Nutrient SensingTriglyceride and HDL-C Dyslipidemia and Risks of Coronary Heart Disease and Ischemic Stroke by Glycemic Dysregulation Status: The Strong Heart Study.28122840
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSex, diabetes, dyslipidemia, and prior MI were similar for all tertiles.28125604
Demographics Domain, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingIn prior myocardial infarction (PMI) patients, diabetes mellitus (DM), dyslipidemia, and hypertension increase the risk of secondary cardiovascular events.28125968
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDiabetes patients with PMI had significantly lower EPA/AA and DHA/AA than diabetes patients without PMI (EPA/AA: P <0.01; DHA/AA: P =0.003), with no such differences in dyslipidemia and hypertension patients.28125968
Hyperandrogenemia, Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingStudies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS).28125989
Aortic valve calcificationDeregulated Nutrient SensingInsulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification.28127113
Cardiovascular calcification, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results.28127113
SLC25A20 gene, Aortic valve calcificationDeregulated Nutrient SensingThe purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0).28127113
Dyslipidemias, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingObesity-related diseases were defined as type 2 diabetes, hypertension, dyslipidemia and non-alcoholic fatty liver disease (NAFLD).28128316
Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Obesity, Prediabetes syndrome, OverweightDeregulated Nutrient SensingThe age-standardized prevalence of obesity, overweight, diabetes, pre-diabetes, dyslipidemia and NAFLD increased from 2007 to 2013 from 15.82% to 19.41%, 35.85% to 41.80%, 6.37% to 9.23%, 16.77% to 23.49%., 53.46% to 65.50%, and 23.48% to 44.31% in males, respectively, and from 13.18% to 18.77%, 31.11% to 37.54%, 4.41% to 8.48%, 8.10% to 16.49%, 41.96% to 54.70%, and 17.56% to 43.06% in females, respectively.28128316
Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Thyroid Diseases, Chronic Obstructive Airway Disease, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingIn models adjusted for age, gender, race, hypertension, diabetes, obesity, dyslipidemia, previous cardiovascular disease, smoking, cancer, chronic obstructive airway disease, thyroid disease, and serum creatinine, higher RHR was associated with increased risk of both cardiovascular mortality and noncardiovascular mortality with a relatively similar magnitude of risk (HR 1.19, 95% CI 1.12 to 1.26 and HR 1.23, 95% CI 1.17 to 1.29, respectively).28132682
Non-alcoholic Fatty Liver Disease, Liver StiffnessDeregulated Nutrient SensingA "healthy diet-optimal sleep" lifestyle pattern is inversely associated with liver stiffness and insulin resistance in patients with nonalcoholic fatty liver disease.28133993
Non-alcoholic Fatty Liver Disease, Liver StiffnessDeregulated Nutrient SensingA "healthy diet-optimal sleep" lifestyle pattern was beneficially associated with insulin resistance and liver stiffness in NAFLD patients independent of body weight status and energy intake.28133993
Glucose Intolerance (disease), Haploinsufficiency, FAM126A geneDeregulated Nutrient SensingWe have previously described that haploinsufficiency of nuclear receptor coactivator 5 (NCOA5) is a genetic defect linking glucose intolerance to HCC.28137631
Data types - AddressDeregulated Nutrient SensingWe find that selenomethionine promotes the initiation of autophagy via the AMPK-mTOR pathway and enhances autophagic flux, thereby facilitating tau clearance in vivo and in vitro We have now identified an additional, novel mechanism by which selenomethionine improves the cognitive function of AD mice.28137967
ObesityDeregulated Nutrient SensingFGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study.28139438
Diabetes MellitusDeregulated Nutrient SensingWe assessed the association of FSH levels with diabetes and measures of insulin resistance among 588 postmenopausal Finnish women.28141661
Autoimmune Diseases, DyslipidemiasDeregulated Nutrient SensingDyslipidaemia was associated with a 44% increased risk of thyroid autoimmunity (OR: 1.44, p = 0.01) and a percentage increase in HbA1c was associated with 46% increased risk of thyroid autoimmunity (OR:1.46, p < 0.0001).28143459
Autoimmune Diseases, Thyroid dysfunction, DyslipidemiasDeregulated Nutrient SensingThyroid autoimmunity in T2DM subjects was significantly associated with female gender, thyroid dysfunction, dyslipidaemia and poor glycemic control.28143459
Impaired T cell functionDeregulated Nutrient SensingPeripheral insulin resistance rather than beta cell dysfunction accounts for geographical differences in impaired fasting blood glucose among sub-Saharan African individuals: findings from the RODAM study.28144712
Impaired T cell functionDeregulated Nutrient SensingOur findings suggest that insulin resistance, rather than beta cell dysfunction, is more important in accounting for the geographical differences in IFBG among sub-Saharan African individuals.28144712
Prediabetes syndromeDeregulated Nutrient SensingRelationship between insulin resistance, hs-CRP, and body fat and serum osteoprotegerin/RANKL in prediabetic patients.28146138
InflammationDeregulated Nutrient SensingGrowing evidence suggest that there is link between inflammation, insulin resistance and OPG, soluble RANKL (sRANKL).28146138
Impaired cognition, Diabetes MellitusDeregulated Nutrient SensingPeople with insulin resistance and type 2 diabetes mellitus (T2DM) are at increased risks of cognitive impairment.28146431
Presenile dementia, "Alzheimers Disease", Glucose Intolerance (disease), AtherosclerosisDeregulated Nutrient SensingMidlife cholesterol predicted dementia with vascular features, but midlife vascular risk factors and glucose intolerance were not related to pure Alzheimer disease without concomitant atherosclerotic cardiovascular disease.28151011
Cerebrovascular accident, Coronary heart disease, Diabetes MellitusDeregulated Nutrient SensingSex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study.28154164
Cardiovascular Diseases, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingStudies exploring the association between insulin resistance (IR) and cardiovascular disease in blacks have not been conclusive, especially for coronary heart disease (CHD).28154164
AHSG protein, humanDeregulated Nutrient SensingFetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children.28154244
AHSG protein, human, Cardiovascular DiseasesDeregulated Nutrient SensingFetuin-A plays a role in insulin resistance and cardiovascular disease.28154244
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingNinety-two per cent of participants had concomitant hypertension (57.5%), dyslipidaemia (26.7%) and eye disease (7.2%).28155315
Nerve DegenerationDeregulated Nutrient SensingHowever, while the roles of AMPK as a metabolic mediator are generally well understood, its performance in neuroprotection and neurodegeneration are not yet well defined.28159472
HyperglycemiaDeregulated Nutrient SensingGiven hyperglycemia is accompanied by an accelerated rate of advanced glycosylation end product (AGE) formation, which is associated with the pathogenesis of diabetic neuronal impairment and, inflammatory response, clarification of the role of AMPK signaling in these processes is needed.28159472
Neurologic Deficits, Prediabetes syndromeDeregulated Nutrient SensingTherefore, we tested the hypothesis that metformin, an AMPK activator, protects against diabetic AGE induced neuronal impairment in human neural stem cells (hNSCs).28159472
Nerve Degeneration, diabeticDeregulated Nutrient SensingThese findings extend our understanding of the central role of AMPK in AGE induced inflammatory responses, which increase the risk of neurodegeneration in diabetic patients.28159472
Dyslipidemias, ObesityDeregulated Nutrient SensingThe development of new-onset CV risk factors after LT, such as dyslipidemia and obesity, independently affected late CV morbidity and mortality.28160394
Dyslipidemias, ObesityDeregulated Nutrient SensingPreexisting CV risk factors, immunosuppressive drugs, but also the early new onset of obesity and dyslipidemia after LT play an important role on late CV complications.28160394
InflammationDeregulated Nutrient SensingDecreased visfatin/Nampt, SIRT1 and SIRT3 in syncytiotrophoblast in PE suggests a lack of placental reserve in metabolic energy efficiency, increased inflammation, and lower resistance to environmental stressors.28161061
ObesityDeregulated Nutrient SensingHyperandrogenic states and obesity in women are associated with insulin-resistance.28161330
Hyperlipidemia, Demographics Domain, Presenile dementia, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingThe pathophysiology of insulin resistance-induced hypertension and hyperlipidemia might entail differences in dementia risk in cases with hypertension and hyperlipidemia without prior diabetes mellitus (DM).28162091
Malignant NeoplasmsDeregulated Nutrient SensingSeveral studies have reported that the overexpression of Sirtuin1 (SIRT1) was associated with poor prognosis in various human cancers.28164517
Adenocarcinoma of lung (disorder)Deregulated Nutrient SensingHowever, little is known regarding the prognostic value of SIRT1 in lung adenocarcinoma.28164517
Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes.28165405
Cardiovascular Diseases, Osage language, Sleep Disorders, Obesity, Sleep Apnea, Obstructive, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObstructive sleep apnoea (OSA) is among the most common sleep disorders and an inter-relationship between OSA, insulin resistance, obesity, type 2 diabetes (T2DM) and cardiovascular diseases has been established.28166768
ObesityDeregulated Nutrient SensingVitamin D status is not related to insulin resistance in different phenotypes of moderate obesity.28177726
ObesityDeregulated Nutrient SensingLow plasma 25-hydroxy-vitamin D (25OHD) and high levels of parathyroid hormone (PTH) are associated with obesity and could play a role in the occurrence of complications such as insulin resistance.28177726
ObesityDeregulated Nutrient SensingOur results confirm the absence of link between vitamin D status and insulin resistance in moderate obesity.28177726
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe excluded participants taking medication for hypertension, dyslipidemia, or diabetes.28178938
Colorectal CarcinomaDeregulated Nutrient SensingIn this study, we demonstrate that the knockdown (KD) of BRG1 promotes cellular senescence by influencing the SIRT1/p53/p21 signal axis in colorectal cancer (CRC).28182012
Primary malignant neoplasm, Colorectal CarcinomaDeregulated Nutrient SensingThe BRG1/SIRT1/p53 signal axis is a novel mechanism of cell senescence in CRC and is a new potential target for cancer therapy.28182012
Metabolic Diseases, ObesityDeregulated Nutrient SensingInsulin resistance (IR) is a hallmark of obesity and metabolic disease.28183786
Cardiovascular DiseasesDeregulated Nutrient SensingAdiponectin and leptin are associated with insulin resistance and cardiovascular disease.28185529
Barrett Esophagus, Increased insulin level, Adenocarcinoma Of EsophagusDeregulated Nutrient SensingInsulin-resistance and hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion Barrett's Esophagus (BE).28185837
Inflammation, ObesityDeregulated Nutrient SensingA direct link between development of insulin resistance and the presence of chronic inflammation, in case of obesity exists, with cytokines playing an important role in glucose metabolism.28186649
Gout, Dyslipidemias, Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingCCAAs often herald an ischaemic stroke and may be seen on the PIs of patients with gout, especially those with increased age, dyslipidaemia or diabetes.28186844
Pulmonary EmphysemaDeregulated Nutrient SensingAMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema.28186975
Pulmonary EmphysemaDeregulated Nutrient SensingHowever, there are no studies regarding the role of AMPK in reducing inflammatory responses and cellular senescence during the development of emphysema.28186975
Lung InjuryDeregulated Nutrient SensingTherefore, we hypothesize that AMPK reduces inflammatroy responses, senescence, and lung injury.28186975
Pulmonary EmphysemaDeregulated Nutrient SensingElastase injection was performed to induce mouse emphysema, and these mice were treated with a specific AMPK activator metformin as well as Compound C. AICAR reduced, whereas Compound C increased CSE-induced increase in IL-8 and IL-6 release and expression of genes involved in cellular senescence.28186975
Hyperglycemia, Coronary ArteriosclerosisDeregulated Nutrient SensingThis finding suggests that beyond insulin resistance that is present in MS, hyperglycemia may also play a role in the development of atherosclerotic disease.28187174
HDL Phospholipid MeasurementDeregulated Nutrient SensingBMI, waist circumference, abdominal visceral adiposity and insulin resistance were associated with more total and small LDL-P, fewer large HDL-P, and a reduction in HDL size (P < 0.05).28187765
Inflammation, Blood Vessel, Antihypertensive AgentsDeregulated Nutrient SensingWe investigated whether Southern Italy resistant hypertensives presented an association between the presence of I and/or D alleles and early vascular damage, inflammation, and insulin resistance.28190172
Blood Vessel, Antihypertensive AgentsDeregulated Nutrient SensingVascular damage may develop and progress independently from other risk factors in resistant hypertensives, likely through the interplay between ACE gene, RAS activity, and insulin resistance.28190172
Psoriatic Juvenile Idiopathic Arthritis, Dyslipidemias, PROS1 geneDeregulated Nutrient SensingOf psoriatic patients, 10.8% had PsA, and after adjusting for age and sex, PsA patients had a significantly higher risk of dyslipidemia than PsV patients (adjusted HR, 1.185; 95% CI, 1.049-1.338).28191654
ProgeriaDeregulated Nutrient SensingMetformin treatment partially restored normal nuclear phenotypes, delayed senescence, activated the phosphorylation of AMP-activated protein kinase and decreased reactive oxygen species formation in HGPS dermal fibroblasts.28192606
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThese changes put individuals at risk for insulin resistance, type II diabetes, and cardiovascular disease.28193782
Obesity, Diabetes MellitusDeregulated Nutrient SensingDuring these time periods, there were also significant increases in obesity (29.8 vs. 36.6%), diabetes (8.3 vs. 11.9%), and insulin resistance (34.7 vs. 42.1%); P value <0.005 for all of them.28195177
melanomaDeregulated Nutrient SensingInsulin resistance has been associated with increased melanoma risk.28196548
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingControlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia.28196738
DyslipidemiasDeregulated Nutrient SensingThese data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions.28196738
Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Bundle-Branch Block, Chronic Kidney DiseasesDeregulated Nutrient SensingUpgrade patients were more often implanted for secondary prevention, suffered more often from atrial fibrillation, chronic kidney disease, diabetes mellitus, and dyslipidemia, and had more often a non-LBBB (left bundle branch block) wide QRS complex, and lower left ventricular ejection fraction.28202628
Abnormality of mitochondrial metabolism, Diabetes MellitusDeregulated Nutrient SensingInsulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction.28204552
Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity, insulin resistance (IR), and diabetes are increasing in youth, especially in girls.28204552
Diabetes MellitusDeregulated Nutrient SensingCross-sectional study of youth in the Exploring Perinatal Outcomes among Children, Resistance to InSulin in Type 1 And Type 2 diabetes, and Androgens and Insulin Resistance Study cohorts.28204552
LymphomaDeregulated Nutrient SensingEfficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphoma.28211162
LymphomaDeregulated Nutrient SensingWe investigated in a phase II open label clinical trial the efficacy and safety of single agent everolimus, an inhibitor of mTORC1, in patients with relapsed/refractory indolent lymphomas.28211162
Hypertension, CTCAE, Demographics Domain, DyslipidemiasDeregulated Nutrient SensingFurther analysis demonstrated that the association between parity and hypertension, DM, and LQTc was mediated by lifestyle and dyslipidemia.28211485
ObesityDeregulated Nutrient SensingCV risk increased in all obesity phenotypes based on insulin resistance except the insulin resistance-normal weight group.28213199
Degenerative polyarthritisDeregulated Nutrient SensingFisetin inhibits IL-1b-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice.28213268
Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSafety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes.28214690
Dyslipidemias, Hypothyroidism, Hyperthyroidism, Coronary heart disease, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dystonia DisordersDeregulated Nutrient SensingAdult-onset dystonia patients and the Italian population shared similar burden of arterial hypertension, type 2 diabetes, coronary heart disease, dyslipidemia, and hypothyroidism, while hyperthyroidism was more frequent in the dystonia population.28215037
Prediabetes syndrome, diabeticDeregulated Nutrient SensingCirculating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance.28216543
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEvidence has shown that endoplasmic reticulum (ER) stress was involved in the progression to type 2 diabetes mellitus (T2DM) and development of insulin resistance.28216543
Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingPrevalence of insulin resistance is increased in patients with obstructive sleep apnea (OSA).28219664
Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Osage languageDeregulated Nutrient SensingBecause insulin resistance is an independent predictor of cardiovascular disease (CVD), this study was initiated to see if pioglitazone administration would improve insulin sensitivity and thereby decrease risk of CVD in overweight/obese, nondiabetic, insulin-resistant patients with untreated OSA.28219664
Osage languageDeregulated Nutrient SensingIn conclusion, enhanced insulin sensitivity can significantly decrease multiple cardiometabolic risk factors in patients with untreated OSA, consistent with the view that coexisting insulin resistance plays an important role in the association between OSA and increased risk of CVD.28219664
Diabetes MellitusDeregulated Nutrient SensingAdditionally, we quantified the effect of insulin resistance in the association between serum magnesium levels and diabetes risk.28224192
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingWe found that 29.1% of the effect of serum magnesium levels on diabetes was mediated through insulin resistance, whereas for prediabetes 13.4% was mediated through insulin resistance.28224192
Diabetes MellitusDeregulated Nutrient SensingBoth findings support a potential causal role of magnesium in the development of diabetes, where the hypothesised pathway is partly mediated through insulin resistance.28224192
Obesity, Abdominal, ETV3 wt AlleleDeregulated Nutrient SensingInsulin resistance indices and abdominal obesity (trunk fat mass/percent) increased across the ferritin concentration quartiles after adjustment for confounders in males and females (P <= 0.011 for trend), and the risk of MetS increased across the ferritin quartiles in males (P < 0.001 for trend) and females (P = 0.001 for trend).28225503
Obesity, Abdominal, ETV3 wt AlleleDeregulated Nutrient SensingThe highest serum ferritin quartile exhibited a 1.62-fold increased risk of MetS (95% CI, 1.28-2.12) in males and a 1.36-fold increased risk of MetS (95% CI, 1.09-1.69) in females compared with the lowest quartile after adjustment for confounders.Our results suggest that ferritin is associated with insulin resistance and abdominal obesity.28225503
Hypertension, CTCAE, Obesity, AtherosclerosisDeregulated Nutrient SensingInsulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM.28225861
Impaired cognitionDeregulated Nutrient SensingCognitive impairment is correlated with insulin resistance degree: the "PA-NICO-study".28229380
Presenile dementia, Demographics Domain, Diabetes MellitusDeregulated Nutrient SensingSeveral epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia.28229380
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingOlder age, African-American race, fee-for-service plan, comorbid hypertension, obesity, and dyslipidemia were associated with higher risk for onset of type 2 diabetes.28230458
Diabetes MellitusDeregulated Nutrient SensingSix weeks of dapagliflozin treatment resulted in improvements in diabetes control, including blood glucose and insulin resistance, and reduced office and 24-h ambulatory blood pressure values.28231831
Breast CarcinomaDeregulated Nutrient SensingMechanism study reveals that BCAT1 activates the mTOR, but not AMPK or SIRT1, signaling to promote mitochondrial biogenesis and function, and subsequently facilitates growth and colony formation of breast cancer cells.28235484
NeoplasmsDeregulated Nutrient SensingIn addition, expression of several HDACs (HDAC1, HDAC2, HDAC5, HDAC11, and Sirt1) was significantly increased in G3 tumors.28235630
Prediabetes syndrome, Cerebrovascular accidentDeregulated Nutrient SensingInsulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke: The ACROSS-China Study (Abnormal Glucose Regulation in Patients With Acute Stroke Across China).28235959
Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance was common in patients with stroke.28235959
Ischemic strokeDeregulated Nutrient SensingThis study investigated the association between insulin resistance and outcomes in nondiabetic patients with first-ever acute ischemic stroke.28235959
Cessation of life, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance was associated with an increased risk of death, stroke recurrence, and poor outcome but not dependence in nondiabetic patients with acute ischemic stroke.28235959
Nucleolar Fibrillar MaterialDeregulated Nutrient SensingMechanistically, miR-181b is upregulated in OS and fibrosa, and it targets TIMP3, SIRT1, and GATA6, correlated with increased gelatinase/MMP activity.28236165
HandDeregulated Nutrient SensingTat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND.28236278
DyslipidemiasDeregulated Nutrient SensingPatients treated with EIAEDs, especially PHT, had higher prevalence of dyslipidemia.28239528
Psoriasis, Diabetes MellitusDeregulated Nutrient SensingPatients with severe psoriasis smoked more heavily, were more likely to have diabetes or insulin resistance and had higher homocysteine and lower high density lipoprotein cholesterol (HDL-C) levels than patients with mild psoriasis (P < 0.05).28240341
Insulin Resistance, Psoriasis, Diabetes MellitusDeregulated Nutrient SensingPsoriasis severity was associated with diabetes, insulin-resistance, smoking habit and higher cardiovascular risk.28240341
Arthralgia, Dyslipidemias, Splenomegaly, FatigueDeregulated Nutrient SensingFM-pSS patients significantly showed more constitutional, fatigue and arthralgia symptoms, splenomegaly, genital, skin and ear involvement and dyslipidaemia (p<0.05), as well as higher ESSPRI and SSDAI scores (p<0.01).28240585
Arthralgia, Adverse Event Associated with Constitutional Symptoms, Dyslipidemias, FatigueDeregulated Nutrient SensingThe presence of fatigue, arthralgia, constitutional symptoms and dyslipidaemia were more likely to coexist in pSS-FM patients.28240585
Hyperglycemia, Endothelial dysfunctionDeregulated Nutrient SensingAssociations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth).28242270
Endothelial dysfunctionDeregulated Nutrient SensingInsulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth.28242270
Polycystic Kidney, Autosomal DominantDeregulated Nutrient SensingRapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.28244683
Hyperthyroidism, Dysglycemia, HypothyroidismDeregulated Nutrient SensingWhile hyperthyroidism and hypothyroidism cause dysglycemia, the relationship between thyroid hormone levels within the normal range and insulin resistance (IR) is unclear.28246105
Cerebrovascular accident, Diabetes MellitusDeregulated Nutrient SensingCardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus.28246237
Electrocardiogram: myocardial infarction (finding), Atherosclerosis, Cerebrovascular accidentDeregulated Nutrient SensingInsulin resistance is highly prevalent among patients with atherosclerosis and is associated with an increased risk for myocardial infarction (MI) and stroke.28246237
Cerebrovascular accident, Ischemic stroke, Diabetes MellitusDeregulated Nutrient SensingThe IRIS trial (Insulin Resistance Intervention after Stroke) demonstrated that pioglitazone decreased the composite risk for fatal or nonfatal stroke and MI in patients with insulin resistance without diabetes mellitus, after a recent ischemic stroke or transient ischemic attack.28246237
Cerebrovascular, Acute Coronary Syndrome, Diabetes MellitusDeregulated Nutrient SensingAmong patients with insulin resistance without diabetes mellitus, pioglitazone reduced the risk for acute coronary syndromes after a recent cerebrovascular event.28246237
AtherosclerosisDeregulated Nutrient SensingIncreased serum semaphorin 3E may in part exacerbate insulin resistance and carotid atherosclerosis.28249916
Dyslipidemias, Sao PauloDeregulated Nutrient SensingConsidering the high prevalence of low HDL-c in the population of Sao Paulo, GI and GL may contribute to the nutritional therapy of this dyslipidemia.28251342
Cardiovascular DiseasesDeregulated Nutrient SensingComparison of two surrogate estimates of insulin resistance to predict cardiovascular disease in apparently healthy individuals.28254109
Congenital Abnormality, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is associated with a cluster of abnormalities that increase cardiovascular disease (CVD).28254109
Breast CarcinomaDeregulated Nutrient SensingKernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors.28258052
Dental PlaqueDeregulated Nutrient SensingBeyond AdipoR1/AdipoR2 expression, a graded decrease in PPAR-a protein levels was observed in relation to carotid plaque instability (P<0.001), whereas AMPK phosphorylation was increased (P<0.05).28258256
FAM126A geneDeregulated Nutrient SensingMechanistic study showed that BCLB expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC cells through the adenosine monophosphate-activated protein kinase AMPK-mTOR signaling cascade.28259820
Liver carcinomaDeregulated Nutrient SensingBCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade.28259820
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is characterized by islet b-cell dysfunction and insulin resistance, which leads to an inability to maintain blood glucose homeostasis.28260062
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is a risk factor for nonalcoholic fatty liver disease (NAFLD).28262209
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingThe associations of dyslipidemia indexes with NAFLD occurrence were assessed by univariate analysis, and multivariate analysis was performed to identify independent dyslipidemia factors predictive of NAFLD.28262209
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingA significant positive association was found between dyslipidemia characteristics and NAFLD in adult males.28262209
Autoimmune Diseases, HyperglycemiaDeregulated Nutrient SensingType B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia.28262212
PliabilityDeregulated Nutrient SensingHowever, it is unknown whether metabolic inflexibility causes insulin resistance.28262678
PliabilityDeregulated Nutrient SensingThe early stages of insulin resistance are accompanied by modest declines in the RQs during sleep and during a clamp, with no changes in fasting RQ or signs of metabolic inflexibility.28262678
PliabilityDeregulated Nutrient SensingOur data therefore suggest that metabolic inflexibility does not cause insulin resistance.28262678
Diabetes MellitusDeregulated Nutrient SensingIncreased ectopic adipose tissue infiltration in skeletal muscle is associated with insulin resistance and diabetes mellitus.28264917
Hypertension, CTCAEDeregulated Nutrient SensingOur novel findings show that decreased muscle attenuation is associated with newly developed hypertension among men of African ancestry, independent of general and central adiposity and insulin resistance.28264917
Diabetes MellitusDeregulated Nutrient SensingAll groups which developed diabetes showed absolute and/or relative increase in visceral fat and impaired b-cell compensation for insulin resistance.28266592
B-Lymphocytes, Gain, Obesity, Diabetes MellitusDeregulated Nutrient SensingThese data suggest that visceral fat gain may induce b-cell failure in compensation for insulin resistance, resulting in diabetes regardless of obesity level.28266592
Dyslipidemias, Diabetes Mellitus, Obesity, Psychogenic, Mental disordersDeregulated Nutrient SensingIn the multivariate analysis the global score strongly correlated with TT < 12 nmol/L (odds ratio [OR] = 3.17; p < 0.05), psychiatric disorders (OR = 2.73), dyslipidemia (OR = 2.07) and diabetes mellitus (OR = 1.64); the somatic sub-component was related to obesity (OR = 8.62), dyslipidemia (OR = 2.2) and TT < 12 nmol/L (OR = 2.09); the psychogenic sub-component correlated with psychiatric disorders (OR = 3.73), stress (OR = 2.42), dyslipidemia (OR = 1.78) and TT < 12 nmol/L (OR = 1.77); and the sexual sub-component was associated with high blood pressure (OR = 2.94).28277894
ObesityDeregulated Nutrient SensingLeukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine linking obesity to skeletal muscle insulin resistance.28278265
Dyslipidemias, Obesity, VisceralDeregulated Nutrient SensingVFA was the strongest predictor of plasma LECT2 that is a potential biomarker linking visceral obesity to dyslipidemia.28278265
ObesityDeregulated Nutrient SensingTwo members of the lipocalin family, lipocalin-2 (LCN-2) and retinol binding protein -4 (RBP-4), play an important role in obesity and insulin resistance.28279688
Glucose Intolerance (disease), ObesityDeregulated Nutrient SensingGlucose intolerance and elevated brain glucose utilization already occur in young, pre-obese rats, suggesting that they precede obesity onset in Zucker fatty rats.28281382
Lupus Erythematosus, AtherosclerosisDeregulated Nutrient SensingInsulin resistance in systemic lupus erythematosus patients: contributing factors and relationship with subclinical atherosclerosis.28281456
Lupus Erythematosus, Lupus Erythematosus, SystemicDeregulated Nutrient SensingInsulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients.28281456
Cerebral artery stenosis, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Hypertension, CTCAE, Dental PlaqueDeregulated Nutrient SensingMultiple logistic regression analysis adjusted for age, gender, diabetes mellitus, dyslipidemia, hypertension, and hyperuricemia showed that a 0.1 increase in VS ratio was related to the presence of ischemic changes [odds ratio (OR): 1.05, 95% CI: 1.01-1.10, p = 0.009], cerebral artery stenosis or occlusion (OR: 1.14, 95% CI: 1.03-1.25, p = 0.007), and cervical plaque (OR: 1.09, 95% CI: 1.05-1.13, p < 0.001).28285092
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingChronic kidney disease (CKD) results in significant dyslipidemia and profound changes in lipid and lipoprotein metabolism.28286957
Cardiac complication, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThe associated dyslipidemia, in turn, contributes to progression of CKD and its cardiovascular complications.28286957
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNo associations with morphological LAA features could be found for patients with diabetes, hypertension, or dyslipidemia.28288200
Hyperhomocysteinemia, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingPrevious studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis.28288621
ObesityDeregulated Nutrient SensingThis finding provides evidence that sDPP4 and GLP-1 may play an important role in the pathogenesis of obesity, suggesting that sDPP4 may be valuable as an early marker for the augmented risk of obesity and insulin resistance.28288852
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingStrong graded associations between screen time, adiposity and insulin resistance suggest that reducing screen time could facilitate early T2D prevention.28288985
ObesityDeregulated Nutrient SensingIn addition, this positive association was more apparent when insulin resistance was accompanied by obesity.28291026
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidaemia as a risk factor in the occurrence of stroke in Nigeria: prevalence and patterns.28292035
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHypertension, diabetes mellitus, dyslipidaemia and smoking are some of the common modifiable risk factors in the occurrence of stroke.28292035
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDyslipidaemia is the most frequent risk factor (85.9%), followed by hypertension (66.0%) and diabetes mellitus (15.1%).28292035
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingDyslipidaemia was significantly higher in the ischaemic stroke compared to haemorrhagic.28292035
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidaemia, particularly low HDL-C, was the most frequent risk factor in our patients with stroke.28292035
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingHence, prevention of dyslipidaemia as well as other risk factors is key to reducing the burden of stroke in our country.28292035
Inflammation, Primary malignant neoplasm, Neoplasms, ObesityDeregulated Nutrient SensingObesity is associated with tumor promoting pathways related to insulin resistance and chronic low-grade inflammation which have been linked to various disease states, including cancer.28293912
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe present study aimed to investigate the association of plasma soluble Ob-R levels with insulin resistance and pancreatic b-cell function in patients with type 2 diabetes.28294581
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPlasma soluble Ob-R levels are independently associated with pancreatic b-cell function, but not with insulin resistance, in patients with type 2 diabetes.28294581
Cerebrovascular Disorders, Peripheral Vascular Diseases, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingThe high risk for MD in mild to moderate CKD patients remains significant after adjustment for personal habits (alcohol drinking and smoking, model 1; OR: 1.371; 95% CI: 1.265-1.486; P < 0.001), comorbidities (dyslipidemia, cerebrovascular disease, and peripheral vascular disease, model 2; OR: 1.369; 95% CI: 1.264-1.484; P < 0.001) and all these factors (model 3; OR: 1.320, 95% CI: 1.218-1.431, P < 0.001).28296786
Inflammation, Obesity, Abdominal, Miller Dieker syndromeDeregulated Nutrient SensingFurthermore, the association between MDS and fasting glucose was fully mediated by adiposity, especially by WC in men aged <45 y and in premenopausal women.Conclusion: Our results suggest that reducing abdominal obesity may play an important role in the pathway through which Med-diet consumption reduces insulin resistance and inflammation.28298537
AtherosclerosisDeregulated Nutrient SensingFatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and play significant roles in the development of insulin resistance and atherosclerosis.28303004
AtherosclerosisDeregulated Nutrient SensingBoth FABP4 and FABP5 are secreted from cells, and their circulating levels are associated with insulin resistance and atherosclerosis.28303004
Diabetes MellitusDeregulated Nutrient SensingSecreted frizzled-related protein-5 (Sfrp5) is a novel adipokine, and it has been found to link insulin resistance with diabetes.28303637
Cardiovascular DiseasesDeregulated Nutrient SensingInsulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease.28304291
Diabetes MellitusDeregulated Nutrient SensingSerum Magnesium Concentrations in the Canadian Population and Associations with Diabetes, Glycemic Regulation, and Insulin Resistance.28304338
Diabetes MellitusDeregulated Nutrient SensingThis study reports current SMCs of Canadians and their associations with demographic factors, diabetes, and measures of glycemic control and insulin resistance using results from the Canadian Health Measures Survey cycle 3 (2012-2013).28304338
Diabetes MellitusDeregulated Nutrient SensingA substantial proportion of Canadians are hypomagnesaemic in relation to a population-based reference interval, and SMC was negatively associated with diabetes and indices of glycemic control and insulin resistance.28304338
Prostate carcinomaDeregulated Nutrient SensingThe combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate cancer, agents that more selectively target PI3K-AKT-mTOR signaling may have a more favorable therapeutic index and should continue to be explored.28314838
Congenital bilateral aplasia of vas deferens, Dyslipidemias, Diabetes Mellitus, Overweight, Aortic valve disorderDeregulated Nutrient SensingCalcific aortic valve disease (CAVD) affects 2-6% of the population over 65 years, and age, gender, smoking, overweight, dyslipidemia, diabetes contribute to the development of this disease.28314924
Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address, Diabetes MellitusDeregulated Nutrient SensingAD is associated with type 2 diabetes mellitus (T2DM) and insulin resistance, and is therefore sometimes called "type 3 diabetes mellitus".28316001
Metabolic Diseases, Refractory anemias, Dyslipidemias, Rheumatoid Arthritis, Chronic inflammatory disorderDeregulated Nutrient SensingRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity.28316139
DyslipidemiasDeregulated Nutrient SensingDyslipidaemia may affect systemic microvasculature from childhood on.28317946
SarcopeniaDeregulated Nutrient SensingWhite blood cell counts, insulin resistance, vitamin D levels and sarcopenia in Korean elderly men.28318372
Inflammation, SarcopeniaDeregulated Nutrient SensingWhether low-grade inflammation, insulin resistance and vitamin D are independently associated with sarcopenia remains unclear.28318372
Increased insulin level, Impaired cognition, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes, hyperinsulinemia, and insulin resistance are associated with cognitive impairment.28319003
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingOur results show that measures of peripheral insulin resistance are unrelated to cognitive performance among individuals with adequately controlled type 2 diabetes.28319003
Hypertensive (finding), Dyslipidemias, Retinal Diseases, Diabetes MellitusDeregulated Nutrient SensingForty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia).28320161
Prostate Cancer Outcomes Study, Cardiovascular DiseasesDeregulated Nutrient SensingThe increased plasma PAF-AH and apoB-PAF-AH activities in patients with H allele of R92H are related to the R92 - H variation, changes in plasma lipoprotein levels, insulin resistance, aging, and gaining weight and thus may be involved in the pathogenesis of PCOS and the increased risks of future cardiovascular diseases.28320416
Inflammation, myocardial injury, Hyperglycemia, Dyslipidemias, physiopathological, Renal InsufficiencyDeregulated Nutrient SensingWe recruited 533 questionnaire-identified apparently healthy individuals, in which laboratory biomarkers were used to detect asymptomatic myocardial injury and dysfunction, ongoing inflammation, hyperglycemia, dyslipidemia, and renal dysfunction.28322756
Increased insulin levelDeregulated Nutrient Sensing2-[4-(5-Chlorobenzothiazothiazol-2-yl)phenoxy]-2-methyl-propionic acid (MHY908) has been shown to prevent insulin resistance-induced hyperinsulinemia in aged rats.28323024
NephritisDeregulated Nutrient SensingHowever, the mechanism underlying MHY908-mediated amelioration of renal inflammation with insulin resistance during aging remains unknown.28323024
FractureDeregulated Nutrient SensingThe contribution of insulin resistance vs adiposity to bone mineral density (BMD), bone turnover, and fractures in humans remains unclear.28324004
Atrial Fibrillation by ECG Finding, Dyslipidemias, Coronary Arteriosclerosis, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingHypertension (58.40%), chronic kidney disease (51.36%), dyslipidaemia (44.62%), ischaemic heart disease (25.75%), and atrial fibrillation (25.32%) were the most represented comorbidities.28324597
Glucose Intolerance (disease)Deregulated Nutrient SensingThe present case suggests that these differences in epitopes may be related to various pathogenic mechanisms including glucose intolerance.28326749
Arthritis, Deafness, Impaired cognitionDeregulated Nutrient SensingThere were some weak associations between SIRT1 SNPs and arthritis, heart attack, deafness, and cognitive impairment.28329314
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is an important independent modifiable risk factor for cardiovascular disease.28330492
Overweight and obesity, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOverweight or obesity (OR = 2.156; 95% CI: 1.863, 2.533), hypertension (OR = 1.643; 95% CI: 1.425, 1.893), or diabetes mellitus (OR = 2.173; 95% CI: 1.661, 2.844) increased the prevalence of dyslipidemia, also these participants were more likely to be aware of their condition, however, this did not increase the likelihood of treatment and control.28330492
DyslipidemiasDeregulated Nutrient SensingLiving in urban areas and higher education level also increased the awareness of dyslipidemia.28330492
Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingPersonal history of coronary heart disease was the strongest influence factors associated with better awareness, treatment and control of dyslipidemia.28330492
Overweight and obesity, DyslipidemiasDeregulated Nutrient SensingOverweight or obesity (OR = 0.404; 95% CI: 0.235, 0.695) and lack of exercise (OR = 0.423; 95% CI: 0.215, 0.830) were associated with poor control of dyslipidemia.28330492
Liver carcinoma, CC-223Deregulated Nutrient SensingCC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo.28334043
CC-223, FAM126A geneDeregulated Nutrient SensingCC-223 concurrently blocked mTORC1 and mTORC2 activation, and its cytotoxicity against HCC cells was much more potent than the traditional mTORC1 inhibitors (RAD001 and rapamycin).28334043
CC-223Deregulated Nutrient SensingmTORC1/2 activation was also blocked in xenografts with CC-223 administration.28334043
CC-223, FAM126A geneDeregulated Nutrient SensingTogether, CC-223 simultaneously blocks mTORC1/2 and efficiently inhibits human HCC cells.28334043
Multiple System AtrophyDeregulated Nutrient SensingInsulin resistance and exendin-4 treatment for multiple system atrophy.28334990
Atrophic, Multiple System AtrophyDeregulated Nutrient SensingWe here tested the hypothesis that multiple system atrophy is associated with brain insulin resistance and showed increased expression of the key downstream messenger insulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in the putamen of patients with multiple system atrophy.28334990
AtrophicDeregulated Nutrient SensingIncreasing evidence also suggests impaired insulin/IGF-1 signalling in multiple system atrophy, as corroborated by increased insulin and IGF-1 plasma concentrations in multiple system atrophy patients and reduced IGF-1 brain levels in a transgenic mouse model of multiple system atrophy.28334990
Hypertensive disease, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIn cause-specific hazard models, HTN (adjusted hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.66 to 1.76), diabetes (HR: 1.49; 95% CI: 1.44 to 1.54), and dyslipidemia (HR: 1.17; 95% CI: 1.14 to 1.21) were all significantly associated with increased risk of developing severe AS (all p < 0.001).28335833
Chronic Obstructive Airway DiseaseDeregulated Nutrient SensingLncRNA-mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease.28339038
ARCN1 geneDeregulated Nutrient SensingThe primary aim of the present study was to explore the mechanisms of AECII senescence regulated by lncRNA-mediated sirtuin 1 (SIRT1) and forkhead box O 3a (FoxO3a) signaling pathways in patients with COPD.28339038
ARCN1 geneDeregulated Nutrient SensingFurthermore, the expression levels of senescence-associated lncRNA1 (SAL-RNA1), SIRT1 and FoxO3a were reduced, but SAL-RNA2, SAL-RNA3, p53 and p21 were upregulated in the lung tissues of patients with COPD compared with control.28339038
ARCN1 geneDeregulated Nutrient SensingThe results of the present study indicated that lncRNA-mediated SIRT1/p53 and FoxO3a signaling pathways may regulate AECII senescence in the pathogenesis of COPD, which may provide a novel experimental basis for the treatment of COPD.28339038
Carotid Intima-Media ThicknessDeregulated Nutrient SensingInsulin resistance is associated with carotid intima-media thickness in non-diabetic subjects.28340367
Carotid Intima-Media ThicknessDeregulated Nutrient SensingEpidemiological studies have analyzed the association between carotid intima-media thickness (CIMT) and insulin resistance, glucose levels or glycated hemoglobin with mixed results.28340367
Dyslipidemias, Depression, CTCAE, ETV3 wt Allele, Diabetes MellitusDeregulated Nutrient SensingDepression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes.28341138
Post-Traumatic Stress Disorder, Hypercholesterolemia, Pulmonary Emphysema, Angina PectorisDeregulated Nutrient SensingPTSD was strongly associated with increased odds for hypercholesterolemia, insulin resistance, angina, heart attack, and emphysema with the greatest odds observed for heart attack (OR= 3.94) and emphysema (OR= 4.06).28342139
ETV3 wt Allele, ObesityDeregulated Nutrient Sensing25-OHD was inversely correlated with glycemic control and cardiovascular risk components of MetS except HDL-C, insulin resistance, and obesity.28346853
ARCN1 gene, Thrombosis, Dyslipidemias, Chronic Obstructive Airway Disease, ObesityDeregulated Nutrient SensingPlasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD).28356730
ObesityDeregulated Nutrient SensingD status and it is well-known that central obesity, with the inflammatory alterations thereto correlated that determine insulin resistance, can be considered the "primum movens" for the development of MetS.28361806
Dyslipidemias, OverweightDeregulated Nutrient SensingOverweight and dyslipidemia were significantly associated with low number of steps (<10,000).28362075
Dyslipidemias, OverweightDeregulated Nutrient SensingOn the other hand, teachers who do not overcome show a greater chance of overweight and dyslipidemia.28362075
Fatty degeneration, Abnormality of mitochondrial metabolismDeregulated Nutrient SensingInsulin resistance and hepatic steatosis were associated with increased ATF3 expression and decreased fatty acid oxidation via mitochondrial dysfunction and were attenuated by in vivo ATF3 silencing.28365312
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDifferent inverse association of large high-density lipoprotein subclasses with exacerbation of insulin resistance and incidence of type 2 diabetes: The Nagahama study.28365559
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe aim of this study was to clarify the difference in prognostic significance of HDL subclasses for exacerbation of insulin resistance and incidence of type 2 diabetes in the general population.28365559
Diabetes MellitusDeregulated Nutrient SensingHDL may have an antidiabetic function; the prognostic value of HDL2-C for diabetes and insulin resistance might be better than that of HDL3-C.28365559
Liver CirrhosisDeregulated Nutrient SensingInterrelationship between insulin resistance and portal haemodynamic abnormality in cirrhosis.28367084
Liver CirrhosisDeregulated Nutrient SensingThe study prospectively examined the interrelationship between insulin resistance (IR) and portal haemodynamic abnormality in cirrhosis.28367084
Hyperglycemia, Dyslipidemias, PsoriasisDeregulated Nutrient SensingPsoriasis patients had a higher prevalence of overweight/obesity, hyperglycemia and dyslipidemia when compared with controls.28371532
AtherosclerosisDeregulated Nutrient SensingInsulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease.28372564
Metabolic Syndrome XDeregulated Nutrient SensingThe higher FT3/FT4 ratio is associated with increased risk of metabolic syndrome parameters and insulin resistance.28374508
Dyslipidemias, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingStatin utilization improves oncologic and survival outcomes in patients with dyslipidemia and surgically treated renal cell carcinoma.28376607
Refractory Cytopenia of Childhood, Dyslipidemias, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingWe evaluated the role of statins in patients who underwent surgery for renal cell carcinoma (RCC) and who had dyslipidemia, as use of statins has been suggested to improve outcomes in RCC.28376607
Refractory Cytopenia of Childhood, DyslipidemiasDeregulated Nutrient SensingTwo-center retrospective study of patients with dyslipidemia who underwent surgery for RCC from 7/1995 to 6/2005.28376607
Refractory Cytopenia of Childhood, DyslipidemiasDeregulated Nutrient SensingIn RCC patients with dyslipidemia, statin use was associated with improved survival outcomes, and was an independent predictor of PFS.28376607
Increased insulin levelDeregulated Nutrient SensingWith the exception of His, which had no association with insulin resistance, Phe, Tyr, Met and Ala were significantly associated with hyperinsulinemia and insulin resistance (P<0.05).28378845
Increased insulin level, Dyslipidemias, HyperglycemiaDeregulated Nutrient SensingAs a result, PFAAs may serve as metabolite predictors of hyperglycemia, hyperinsulinemia and dyslipidemia in healthy participants.28378845
Dyslipidemias, Myocardium, Aortic valve disorderDeregulated Nutrient SensingMyocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible.28380047
One Vessel Coronary Disease, Dyslipidemias, Atherosclerosis of arteryDeregulated Nutrient SensingConversely to findings from studies in other Arab and Asian countries, where small vessel disease is the most frequent subtype, our study showed a predominance of large artery atherosclerosis (53.5%) which, in comparison with other subtypes, was found to be associated with dyslipidemia (OR= 3.82, 95% CI= [1.76-8.28]; p=0.001).28380323
Impaired cognitionDeregulated Nutrient SensingPrevention and treatment of insulin resistance might help reduce cognitive decline later in life.28381479
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingIn men, obesity was negatively associated with HRQOL through diabetes mellitus, hypertension, and dyslipidemia and positively associated with HRQOL through SRH.28382521
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension or type-2 diabetes patients were selected as the CDMP group, while dyslipidemia patients were the control group.28383439
Dyslipidemias, HypothyroidismDeregulated Nutrient SensingDyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C).28384120
Cerebrovascular Disorders, Dyslipidemias, Hypothyroidism, AtherosclerosisDeregulated Nutrient SensingIt is important to determine serum lipid levels, especially serum sdLDL-C levels at an early stage of subclinical hypothyroidism, since they represent atherogenic LDL particles and are better indicators for dyslipidaemia in subclinical hypothyroidism and the development of atherosclerosis with potential complications such as cardiovascular and cerebrovascular diseases.28384120
diabeticDeregulated Nutrient SensingRelationship between sleep parameters, insulin resistance and age-adjusted insulin like growth factor-1 score in non diabetic older patients.28384333
Sleep Apnea, Obstructive, Osage languageDeregulated Nutrient SensingSleepiness, short or long sleep duration and obstructive sleep apnea (OSA) are associated with insulin resistance (IR).28384333
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSubjects with diabetes mellitus, hypertension, and/or dyslipidemia were classified as "metabolically unhealthy."28385358
SLC25A20 gene, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCompared to individuals without luminal narrowing or CAC, individuals without luminal narrowing but CAC>0 were older, more likely to be male and had higher rates of diabetes, hypertension, and dyslipidemia.28385391
Fibrosis AssessmentDeregulated Nutrient SensingSirtuins (SIRTs), particularly SIRT1, SIRT3, and SIRT6, are well-known mediators of aging; however, limited data exist on the contribution of sirtuins to lung fibrosis.28385812
DyslipidemiasDeregulated Nutrient SensingRelationship of serum novel adipokine chemerin levels with body composition, insulin resistance, dyslipidemia and diabesity in Saudi women.28387898
ARCN1 gene, Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCompared to the control group, patients with COPD had a higher risk of dyslipidaemia (OR 3.24, 95% CI; 2.21-4.75), diabetes type 2 (OR 1.52, 95% CI; 1.01-2,28), and ischaemic heart disease (OR 2.34, 95% CI; 1.22-4.49).28390852
DyslipidemiasDeregulated Nutrient SensingIn the case of dyslipidaemia, an increased risk was obtained when adjusted for age, gender, and consumption of tobacco (OR 5.04, 95% CI; 2.36-10.74).28390852
ARCN1 gene, Dyslipidemias, Coronary Arteriosclerosis, Hypertension, CTCAE, Cardiac ArrhythmiaDeregulated Nutrient SensingPatients with COPD resident in the Canary Islands have a high prevalence of hypertension, dyslipidaemia, ischaemic heart disease, and cardiac arrhythmia.28390852
ARCN1 gene, DyslipidemiasDeregulated Nutrient SensingCompared to general population, patients with COPD have a significant increase in the risk of dyslipidaemia.28390852
ObesityDeregulated Nutrient SensingOne child developed a deleterious metabolic phenotype with obesity and insulin resistance (homeostatic model assessment = 3.08) associated with higher mean hepatic transaminases (149 vs 98, 88, and 61 IU/L) and increased mean cIMT values (raising from 0.47 to 0.5 mm vs 0.43 and 0.43 mm).28391883
Hypertensive disease, DyslipidemiasDeregulated Nutrient SensingDM, HTN and dyslipidemia co-existed in 1.8% of the population.28395951
Hypertensive disease, Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and dyslipidemia are the most common comorbidities among persons with DM and HTN alone and comorbid DM and HTN.28395951
Hypertensive disease, Dyslipidemias, ObesityDeregulated Nutrient SensingFactors strongly associated with comorbid DM and HTN include elderly age group, dyslipidemia, obesity and family history of DM.28395951
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingThe study reported high burden of comorbid diabetes and hypertension among the elderly, strongly associated with obesity and dyslipidemia.28395951
Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Hypertension, CTCAE, Chronic Kidney DiseasesDeregulated Nutrient SensingHyperuricemia (defined as >7 mg/dL in men and >=6 mg/dL in women) was associated with increased cumulative incidence of hypertension (14.9% versus 6.1%; P<0.001), dyslipidemia (23.1% versus 15.5%; P<0.001), chronic kidney disease (19.0% versus 10.7%; P<0.001), and overweight/obesity (8.9% versus 3.0%; P<0.001), while diabetes mellitus (1.7% versus 0.9%; P=0.087) showed a trend but did not reach statistical significance.28396536
Dyslipidemias, VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)Deregulated Nutrient SensingDyslipidemia was significantly associated with vitiligo (67%) compared with the control group (48%) (OR: 0.44; 95% CI: 0.21-0.92; p=0.03).28397947
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding), Dyslipidemias, Diabetes Mellitus, Hypothyroidism, Chronic disease, Injury of kidney, ObesityDeregulated Nutrient SensingConclusion: There is an increased risk of chronic diseases among vitiligo patients including diabetes, dyslipidemia, hypothyroidism, renal injuries, and obesity.28397947
Periodontitis, Inflammatory disorder, Chronic disease, Cardiovascular DiseasesDeregulated Nutrient SensingPeriodontitis is an inflammatory disease affecting the tooth supporting tissues (periodontium) and associated with chronic diseases such as cardiovascular disease and insulin resistance.28401926
Incontinence, Dyslipidemias, Diabetes Mellitus, Erectile dysfunction, Hypertension, CTCAEDeregulated Nutrient SensingThe most common SDg prior to surgery were hypertension, lower urinary tract symptoms, dyslipidemia, diabetes mellitus and erectile dysfunction, but none did show a greater trend towards post-surgical incontinence.28403593
Gestational Diabetes, Glucose Intolerance (disease)Deregulated Nutrient SensingGestational diabetes is a strong risk factor for postpartum progression to glucose intolerance.28404514
Glucose Intolerance (disease), Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingThe American Diabetes Association(ADA) criteria applied for definition of postpartum glucose intolerance (pre-diabetes or diabetes) .28404514
DyslipidemiasDeregulated Nutrient SensingThis overlapped therapeutic lifestyle change method may serve as a cost-effective adjunct and ensure the continuity of high-quality health services for patients with dyslipidaemia.28404531
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %).28405675
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThere is an increasing prevalence of hypertension and dyslipidemia due to globalization and adoption of westernized dietary habits in India.28405988
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingNutritional strategies for reducing salt intake, saturated fat and balancing energy nutrients should be urgently applied in Indian hypertensive and dyslipidemia patients.28405988
Hyperglycemia, Prediabetes syndromeDeregulated Nutrient SensingThe levels of kallistatin are higher in individuals with prediabetes, but are similar in subjects with and without insulin resistance, which indicates that the main factor for its increased levels may be hyperglycemia and not insulin sensitivity state.28406338
Diabetes MellitusDeregulated Nutrient SensingFasting triglycerides as a predictor of incident diabetes, insulin resistance and b-cell function in a Canadian First Nation.28406758
Diabetes MellitusDeregulated Nutrient SensingThe purpose of this study was to test for an association between fasting serum triglycerides and incident diabetes, changes in insulin resistance and changes in b-cell function in a Manitoba First Nation cohort.28406758
Diabetes MellitusDeregulated Nutrient SensingFasting triglycerides may be useful as a clinical predictor of insulin resistance and diabetes development among First Nations populations.28406758
Polycystic Ovary SyndromeDeregulated Nutrient SensingThe Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.28407657
Prostate Cancer Outcomes Study, Polycystic Ovary SyndromeDeregulated Nutrient SensingThis study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in women with polycystic ovary syndrome (PCOS).28407657
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingOmega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PCOS women significantly improved indices of insulin resistance, total and free testosterone.28407657
DyslipidemiasDeregulated Nutrient SensingAmong those who were CCAA positive, there was a significant increased prevalence of dyslipidemia with age.28407989
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe results of this study might suggest that prescribers and patients with diabetes may be reluctant to initiate statin therapy for primary prevention without a concurrent diagnosis of dyslipidemia.28408169
Communicable Diseases, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBACKGROUND Chronic hepatitis C virus (HCV) infection is associated with increased insulin resistance and risk of type 2 diabetes.28413215
Dyslipidemias, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingIn the presence of cardiovascular disease, these age-associated alterations are accelerated, contributing in the appearance or the progression of cardiovascular disease, such as high blood pressure, dyslipidemia, smoking and diabetes.28413991
HIV-1 Infection Pathway, DyslipidemiasDeregulated Nutrient SensingPitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial.28416195
Left-Sided Heart Failure, Cerebrovascular accident, Osage languageDeregulated Nutrient SensingThe new SLEEP Inventory (Sex, Left heart failure, ESS, Enlarged neck, weight [in Pounds], Insulin resistance/diabetes, and National Institutes of Health Stroke Scale) performed modestly better than other instruments in identifying patients with OSA, showing reasonable discrimination in the development (c-statistic .732) and validation (c-statistic .731) study populations, and having the highest negative predictive value of all in struments.28416405
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn T2D, NAFLD was associated with several markers of insulin resistance.28417532
Increased insulin level, Hypoinsulinaemia (disorder)Deregulated Nutrient SensingFurthermore, Jinlida alleviated insulin resistance with hyperinsulinemia and promoted insulin secretion with hypoinsulinemia.28418191
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe non-negligible prevalence of MS among HIV-infected patients under cART requires a careful and periodic monitoring of its components, with particular attention to dyslipidemia and hypertension.28420298
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingInsulin resistance was observed in 146 (47.1%) children; the frequencies of dyslipidemia and hypertension were 31% and 19.4%, respectively.28421785
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingVitamin D deficiency could contribute to the morbidities associated with childhood obesity, such as insulin resistance or diabetes mellitus, increased cardiovascular/cardiometabolic risks, atherogenic dyslipidemia, and hypertension.28421785
DyslipidemiasDeregulated Nutrient SensingThe mean atherogenic dyslipidemia ratio was higher in the deficient group (p = 0.049).28421785
Diabetes MellitusDeregulated Nutrient SensingHOMA of insulin resistance (IR) scores and disposition index 30 minutes after glucose load (DI30) were increased in early-onset diabetes participants.28422176
Failure, Diabetes MellitusDeregulated Nutrient SensingIn conclusion, patients diagnosed with diabetes at a younger age are characterized by a similar cardiovascular risk profile with increased insulin resistance and more severe beta cell failure than patients diagnosed at a later age.28422176
Diabetes MellitusDeregulated Nutrient SensingSerum resistin positively correlates with serum lipids, but not with insulin resistance, in first-degree relatives of type-2 diabetes patients: an observational study in China.28422857
Kidney Diseases, diabeticDeregulated Nutrient SensingHeterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.28424160
SIRT1 gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHuman T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3a than nondiabetic kidneys.28424160
Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingOur results demonstrate that hnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.28424160
deficiency aspectsDeregulated Nutrient SensingGNE deficiency may affect levels of UDP-GlcNAc, a key metabolite in the nutrient-sensing hexosamine biosynthetic pathway, but this modest effect did not fully account for the change in N-linked glycan structure.28424265
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of hypertension(62.5 vs 16.9%) and dyslipidemia(49.5 vs 9.7%) were more prevalent in patients with type 2 diabetes compared to non-diabetic cases.28425463
Hypertension, CTCAE, Dyslipidemias, diabeticDeregulated Nutrient SensingWe also confirmed that the prevalence of hypertension and dyslipidemia are 3.7-fold and 5.1-fold higher, respectively, in diabetic patients than in non-diabetic adults.28425463
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe control group patients were referred by an endocrinologist to be tested for NAFLD; most of these patients had diabetes, hypertension, or dyslipidemia.28426815
Obesity, Visceral, Prehypertension, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Renal InsufficiencyDeregulated Nutrient SensingPrevalences of prehypertension, hyperuricemia, visceral obesity and dyslipidaemia are apparent in very elderly women, while diabetes mellitus, renal dysfunction are common in very elderly men.28428538
Acute Coronary SyndromeDeregulated Nutrient SensingPossible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis.28430816
GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingWe compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104).28430816
Acute Coronary Syndrome, DyslipidemiasDeregulated Nutrient SensingLow-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial.28430910
Dyslipidemias, GDC AJCC Clinical Stage TerminologyDeregulated Nutrient SensingAlthough intensive lowering with standard pitavastatin plus ezetimibe showed no more cardiovascular benefit than standard pitavastatin monotherapy in ACS patients with dyslipidaemia, statin plus ezetimibe may be more effective than statin monotherapy in patients with higher cholesterol absorption; further confirmation is needed.28430910
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThe same result was also obtained after adjustment for cardiovascular risk factors including age, dyslipidemia, diabetes mellitus and hypertension (p < 0.05).28431391
Hyperglycemia, Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingFrom 1999 to 2010, dyslipidemia declined and abdominal obesity and hyperglycemia increased among individuals with prior MI.28431619
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingHomozygous familial hypercholesterolaemia (HoFH) is a rare form of inherited dyslipidemia resistant to conventional cholesterol-lowering medications so that lipoprotein apheresis (LA) is usually required.28432645
InflammationDeregulated Nutrient SensingWhile BM-MNC telomere attrition was not related with alterations in TERT, TRF1/2 and Sirt1 expression, IFNy levels were associated with p21Cip1/p16lnk4A upregulation, suggesting a link between inflammation and cellular senescence.28434530
DyslipidemiasDeregulated Nutrient SensingOmega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients.28434760
HD Term Type, DyslipidemiasDeregulated Nutrient SensingAlthough the n-3 PUFA supplementation was associated with lower concentrations of isoprostane and advanced oxidation protein product and higher HDL levels, it was not sufficient for the improvement of highly prevalent risk factors, such as OS and dyslipidemia in HD patients.28434760
Glucose Intolerance (disease), Prediabetes syndrome, Diego blood group systemDeregulated Nutrient SensingOur results suggest that reduction of DI promptly reflects the alteration of early glucose intolerance in Japanese population presenting with prediabetes.28436739
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingBranched chain amino acids (BCAA) may be involved in the pathogenesis of insulin resistance and are associated with type 2 diabetes mellitus (T2DM) development.28437198
Dyslipidemias, "cytidylyl-3-5-guanosineDeregulated Nutrient SensingThis CPG is a practical tool that endocrinologists, other health care professionals, health-related organizations, and regulatory bodies can use to reduce the risks and consequences of dyslipidemia.28437620
Hypercholesterolemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingSpecial consideration is given to individuals with diabetes, familial hypercholesterolemia, women, and youth with dyslipidemia.28437620
InflammationDeregulated Nutrient Sensing25(OH)D Levels in Relation to Gender, Overweight, Insulin Resistance, and Inflammation in a Cross-Sectional Cohort of Northern Italian Workers: Evidence in Support of Preventive Health Care Programs.28443804
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingOver three-quarters of the entire group had dyslipidemia and 18.3% had hypertension, but only 3.0% had diabetes.28444007
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAdditionally, high rates of hypertension and dyslipidemia were found, but a low rate of diabetes mellitus.28444007
Albuminuria, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAdditionally, the SIRT1 gene collaborates with the p300 gene and participates in promoting albuminuria in type 2 diabetes mellitus patients.28444663
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingDiagnostic accuracy of serum alanine aminotransferase as biomarker for nonalcoholic fatty liver disease and insulin resistance in healthy subjects, using 3T MR spectroscopy.28445310
Stomach CarcinomaDeregulated Nutrient SensingPhosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer.28446188
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe clopidogrel group had a greater proportion of males and a higher rate of comorbidities, such as diabetes mellitus and dyslipidemia, than the control group.28451807
Cardiovascular morbidity, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is reported in 27 - 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity.28454530
DyslipidemiasDeregulated Nutrient SensingThe overall prevalence of dyslipidemia was 6.4% in the population-based cohort and 28.0% in the cohort with overweight/obesity.28454530
DyslipidemiasDeregulated Nutrient SensingThe odds ratio for exhibiting dyslipidemia in the cohort with overweight/obesity compared with the population-based cohort was 6.2 (95% CI: 4.9 - 8.1, P < 2*10-16).28454530
Dyslipidemias, ObesityDeregulated Nutrient SensingChildren and adolescents with obesity have increased concentrations of circulating lipids and exhibit an increased prevalence of dyslipidemia.28454530
Hemorrhage, Lung InjuryDeregulated Nutrient SensingImpaired AMPK Activity Drives Age-Associated Acute Lung Injury after Hemorrhage.28459384
Thrombosis, Dyslipidemias, Malignant NeoplasmsDeregulated Nutrient SensingDyslipidemia, prolonged immobilization, deep vein thrombosis, post-operative state, malignancy and post-partum period were the commonly reported risk factors.28460762
DyslipidemiasDeregulated Nutrient SensingPrevalence of dyslipidemia was high in this cohort of patients studied although the exact association of it in APE could not be determined.28460762
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingFamily history of CAD was in 50%, diabetes 44%, hypertension 49%, history of dyslipidemia 11%, smoking/tobacco use 39%, and sedentary habits in 20%.28460769
Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAEDeregulated Nutrient SensingHigher proportions of dyslipidemia (85.7%), hypertension (72.8%), and ischemic heart disease (IHD) (73.2%) were associated with urban residency (P<0.01).28461753
Dyslipidemias, ObesityDeregulated Nutrient SensingNo association was found with obesity and dyslipidemia.28462541
Inflammation, Dyslipidemias, Dental Plaque, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAmeliorating dyslipidemia in type 2 diabetic patients by femoropopliteal artery plaque resection under acute inflammation response.28462578
Virus Diseases, HIVDeregulated Nutrient SensingInsulin Resistance(IR) is increasing in Africans as well as among the Human Immunodeficiency Virus(HIV) infected population for several reasons which include the viral infection itself and the use of Highly active antiretroviral therapy (HAART).28462827
ObesityDeregulated Nutrient SensingArterial stiffening, insulin resistance and acanthosis nigricans in a community sample of adolescents with obesity.28465605
Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight, Chronic Kidney DiseasesDeregulated Nutrient SensingObesity and overweight, diabetes, hypertension, and dyslipidemia are major risk factors for CKD.28467510
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingOur findings warrant further research into the consequences of the metabolic effects of light for the diagnosis and prevention of hyperglycemia and dyslipidemia.28470119
LipolysisDeregulated Nutrient SensingA greater proportion of ERa/ERb protein in the nuclear fraction of SAT at baseline (placebo day) was associated with greater reduction in SAT insulin resistance (i.e., better suppression of lipolysis, EC50) in response to E2 (r = -0.431, p<0.05).28472101
HelminthiasisDeregulated Nutrient SensingEmerging evidence suggests that helminth infections are associated with lower insulin resistance (IR).28472383
Chronic Kidney DiseasesDeregulated Nutrient SensingSerum RBP4 and CKD: Association with insulin resistance and lipids.28473187
Diabetes MellitusDeregulated Nutrient SensingSerum RBP4 is new adipokine and it has been related to insulin resistance and diabetes risk in animal and clinical studies.28473187
DyslipidemiasDeregulated Nutrient SensingDyslipidemia among parents was associated with 1.98 higher odds of dyslipidemia among youth (95% CI, 1.37-2.87).28476328
DyslipidemiasDeregulated Nutrient SensingLong-term treatment with anacetrapib 100 mg substantially reduced LDL-C, increased HDL-C and was well tolerated in Japanese patients with dyslipidemia (ClinicalTrials.gov number NCT01760460).28478132
Dyslipidemias, Coronary Artery Disease, Diabetes MellitusDeregulated Nutrient SensingCoronary artery disease (P = 0.049), dyslipidemia (P < 0.001), diabetes (P = 0.047), and history of multiple prior infrainguinal procedures (P = 0.029) were associated with increased complications following groin wound reconstruction.28478163
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe most frequent comorbidities were hypertension (70%), dyslipidemia (51%), diabetes (24%) and obesity (23%).28478208
Diastolic blood pressureDeregulated Nutrient SensingBMI was significantly associated with systolic and diastolic blood pressure and insulin resistance.28478437
Postmenopausal stateDeregulated Nutrient SensingInteraction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk.28478612
Diabetes MellitusDeregulated Nutrient SensingTLR3 is implicated in insulin resistance and type 2 diabetes mellitus (T2DM).28479387
Federated States of MicronesiaDeregulated Nutrient SensingWhen compared to FM, SAT and VAT had the strongest association with insulin resistance in adults.28481336
Proteinuria, Hyperglycemia, Dyslipidemias, Hyalinosis, Systemic, Hypertransaminasaemia, Hypertension, CTCAE, FatigueDeregulated Nutrient SensingCommon side effects were hypertension, HFS, fatigue, transaminitis, hyperglycemia, dyslipidemia, and proteinuria which were quite manageable.28485355
Migraine Disorders, DyslipidemiasDeregulated Nutrient SensingIntroduction Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context.28486852
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia and history of stroke were also significantly associated with an elevated risk for CA of cardiac origin.28487155
Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingWhereas CA of cardiac origin is predicted by history of cardiovascular disease, dyslipidemia and diabetes mellitus, the main risk factors for CA of non-cardiac origin are obesity and hypertension.28487155
InflammationDeregulated Nutrient SensingOur data suggest that as dietary GL increases within the moderate range, there is no detectable change in markers of inflammation or insulin resistance, despite which there is a negative effect on body composition.28492492
Electrocardiogram: myocardial infarction (finding), DyslipidemiasDeregulated Nutrient SensingMale patients comprised 66%, 30% were diabetics, 46% had dyslipidemia, 28% previously sustained a myocardial infarction, and 9.4% underwent prior cardiovascular surgery.28492786
Carotid Stenosis, DyslipidemiasDeregulated Nutrient SensingDyslipidemia is a well-known risk factor for carotid stenosis progression, but triglycerides have attracted little attention.28495179
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMultivariable regression analysis showed that BMI was associated positively with insulin resistance and inversely with insulin sensitivity in type 2 diabetes mellitus group (all P<0.05).28496312
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingHigher BMI was associated with increased insulin resistance and decreased insulin sensitivity in elderly Asian population with type 2 diabetes mellitus.28496312
Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance is associated with endothelial dysfunction and ensuing cardiovascular diseases in type 2 diabetes mellitus (T2DM) patients.28497367
Atherosclerosis, diabeticDeregulated Nutrient SensingFactors which enhance insulin resistance increase the risk for onset and progression of coronary atherosclerosis irrespective of a diabetic background.28497367
Carcinoma of lungDeregulated Nutrient SensingWestern blot analysis and confocal microscopy results indicated that overexpression of miR-138 or interference of Sirt1 expression could inhibit lung cancer cell autophagy activity possibly through AMPK-mTOR signaling pathway.28498463
Neoplasm Metastasis, Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingmiR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1.28498463
Carcinoma of lungDeregulated Nutrient SensingThe protein expression of the potential target gene Sirt1 in lung cancer cells were determined by western blot analysis.28498463
Carcinoma of lungDeregulated Nutrient SensingIt may inhibit the proliferation, invasion and migration of lung cancer through downregulation of Sirt1 expression and activation of cell autophagy.28498463
SLC25A20 gene, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingAmong patients with CAC, age, diabetes, hypertension and dyslipidemia were associated with an increasing CAC score in males and females, with diabetes being the strongest dichotomous risk factor (p<0.001 for both).28499962
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingTo a lesser extent, hypertension and dyslipidemia were also associated in the high CAC quantiles and the low CAC quantiles respectively.28499962
Prostate Cancer Outcomes Study, DyslipidemiasDeregulated Nutrient SensingThis supports prior findings that adiposity is a key driver of dyslipidaemia in PCOS and highlights the need for weight management through lifestyle interventions.28500248
Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa Population Study and the Framingham Offspring Study.28502490
Cerebrovascular, Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingEffects of statin therapy on cerebrovascular and renal outcomes in patients with predialysis advanced chronic kidney disease and dyslipidemia.28502499
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingStatins may reduce the all-cause mortality and reduced the risk of dialysis in patients with predialysis advanced CKD and dyslipidemia.28502499
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA total of 1022 Finnish adults diagnosed with CAD, diabetes, hypertension, or severe hereditary dyslipidemia completed an electronic questionnaire survey during a visit in 1 of the 84 community pharmacies participating in the study.28502506
DyslipidemiasDeregulated Nutrient SensingThirty-four percent of the survey respondents were diagnosed with CAD or severe hereditary dyslipidemia and 82% were current or former statin users.28502506
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingRelationship between noninvasive scores of nonalcoholic fatty liver disease and nuclear magnetic resonance lipoprotein abnormalities: A focus on atherogenic dyslipidemia.28502513
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHypertension was more prevalent among black patients, diabetes and obesity were more prevalent among female and black patients, dyslipidaemia was more prevalent among male and white patients, and comorbidities were more prevalent among older patients (all P < 0.001).28503912
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized.28505362
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingManaging the challenging homozygous familial hypercholesterolemia patient: Academic insights and practical approaches for a severe dyslipidemia, a National Lipid Association Masters Summit.28506384
Hypercholesterolemia, DyslipidemiasDeregulated Nutrient SensingThe following article represents material presented and discussed at a symposium hosted by the National Lipid Association hosted entitled "Managing the Challenging Homozygous Familial Hypercholesterolemia Patient-Academic Insights and Practical Approaches for a Severe Dyslipidemia" on November 7, 2015 in Orlando, FL.28506384
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe major types of dyslipidemia in Chinese population are hypertriglyceridemia and low HDL-C.28506386
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingIn nonstatin users, the major types of dyslipidemia were hypertriglyceridemia combined with low HDL-C, isolated low HDL-C, and isolated hypertriglyceridemia, accounting for 21.60%, 19.70%, and 14.99%, respectively.28506386
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThirty (60%) were current or ex-smokers, 4 (8%) had diabetes, 8 (16%) had hypertension and 26 (52%) had dyslipidaemia.28506456
ARCN1 geneDeregulated Nutrient SensingThe protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD.28506610
ARCN1 geneDeregulated Nutrient SensingRecently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD.28506610
ARCN1 geneDeregulated Nutrient Sensings120S was decreased in the patients with COPD, potentially as reflected by the reduced SIRT1 within cells as a result of oxidative stress, and might be a potential biomarker for certain disease characteristics of COPD.28506610
vascular inflammations, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNon-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice.28507343
Non-alcoholic Fatty Liver Disease, Vascular System InjuriesDeregulated Nutrient SensingWe aimed to determine whether TRAIL protects against insulin resistance, NAFLD and vascular injury.28507343
vascular inflammations, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThese findings suggest that TRAIL protects against insulin resistance, NAFLD and vascular inflammation.28507343
Inflammation, ObesityDeregulated Nutrient SensingIncreased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity.28508444
ObesityDeregulated Nutrient SensingThe adipose tissue IL-18R/IL-18 expression is enhanced in obesity which associates with proinflammatory gene signature and insulin resistance in these individuals.28508444
Hypertension, CTCAE, Dyslipidemias, ObesityDeregulated Nutrient SensingHypertension was reported for 60 patients (82%); dyslipidemia, for 56 (77%); obesity, for 37 (51%); and smoking, for 10 (14%).28508856
Dyslipidemias, Dental Plaque, Disease of capillariesDeregulated Nutrient SensingA multivariate regression analysis showed that the carotid plaque score, but not carotid IMT, was significantly associated with dyslipidemia (P = 0.03) and microangiopathy (P = 0.01).28508856
Impaired cognition, Presenile dementia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingHypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults.28509343
Colorectal Neoplasms, ObesityDeregulated Nutrient SensingObesity and insulin resistance are risk factors for colorectal neoplasms (CRN), but data regarding metabolic status, obesity, and CRN are lacking.28510711
Inflammation, Heart failure, Anemia, Chronic Kidney DiseasesDeregulated Nutrient SensingFurthermore, anemia, insulin resistance, inflammation, and poor glycemic control are independent risk factors for the development of heart failure among patients with chronic kidney disease.28515118
Glucose Intolerance (disease)Deregulated Nutrient SensingIs bisphenol A exposure associated with the development of glucose intolerance and increased insulin resistance in Thais?28516806
DyslipidemiasDeregulated Nutrient SensingMultivariate logistic regression showed a history of dyslipidemia (odds ratio [OR] = 6.83, P = .008), and an SIR lower than the median (OR = 4.73, P = .014) were independently associated with presence of CMI(s) in ipsilateral hemisphere to an MCA-M1 stenosis.28522230
DyslipidemiasDeregulated Nutrient SensingExcept for a history of dyslipidemia, the hemodynamic significance of the arterial stenosis may contribute to the presence of ipsilateral CMI(s) in these patients, which warrants further investigation in prospective, longitudinal studies.28522230
Communicable Diseases, Diabetes MellitusDeregulated Nutrient SensingHCV infection was found to be associated with insulin resistance, a step towards type 2 diabetes mellitus (T2DM).28523926
Metabolic Diseases, Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity in children is associated with early onset metabolic disorders such as dyslipidemia, high blood pressure and type 2 diabetes.28526006
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidaemia is a major contributor to the increased risk of cardiovascular disease (CVD) associated with type 2 diabetes (T2D).28526014
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThere is a need for increased implementation of guideline recommendations such as American College of Cardiology/American Heart Association for the management of dyslipidaemia in patients with T2D.28526014
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDeficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia.28526388
DyslipidemiasDeregulated Nutrient SensingDeficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes.28526388
DyslipidemiasDeregulated Nutrient SensingRisk for incident dyslipidemia was determined for those without baseline dyslipidemia.28526388
DyslipidemiasDeregulated Nutrient SensingThose with deficient compared with optimal 25(OH)D had modestly increased risk for incident dyslipidemia in demographic-adjusted models (relative risk [RR], 1.19; 95% CI, 1.02-1.39), which was attenuated in fully adjusted models (RR, 1.12; 95% CI, 0.95-1.32).28526388
Dyslipidemias, Borderline Personality Disorder, Diabetes Mellitus, Bronchopulmonary Dysplasia, Hypertension, CTCAEDeregulated Nutrient SensingPrevious studies suggested that patients with borderline personality disorder (BPD) had a higher prevalence of stroke-related risk factors, such as hypertension, dyslipidemia, and diabetes mellitus.28528281
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMedical record data for diabetes and dyslipidemia were obtained.28529225
Dyslipidemias, ObesityDeregulated Nutrient SensingObesity and a lipid rich diet may have contributed to the dyslipidemia observed in CP patients.28531465
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiabetes mellitus, hypertension and dyslipidemia were more common in TVD patients.28531788
Diabetes MellitusDeregulated Nutrient SensingHereafter, a new approach for treating insulin resistance and diabetes may be developed by new therapeutic potentials such as neutralization of Ab by anti-Ab antibodies.28534431
Prostate Cancer Outcomes Study, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular DiseasesDeregulated Nutrient SensingWe also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS.28535403
Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Data types - AddressDeregulated Nutrient SensingEpidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD.28538088
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe modifiable risk factors, other than current smoking habit (5.3%), were common: hypertension (83.8%), dyslipidaemia (85.9%) and diabetes mellitus (57.4%).28540395
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA majority of patients with hypertension (96.3%), dyslipidaemia (93.8%) and diabetes mellitus (78.5%) received medications for their conditions.28540395
Rectal CarcinomaDeregulated Nutrient SensingRectal cancer surgery induced profound insulin resistance, affecting glucose and fatty acid metabolism.28541810
IFNG wt AlleleDeregulated Nutrient SensingOur data suggest that IFG occurred in 30% of b TM children, perhaps due to insulin resistance secondary to iron overload.28544032
Intellectual Disability, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingType 2 diabetes and glucose intolerance in a population with intellectual disabilities: the STOP diabetes cross-sectional screening study.28544066
diabeticDeregulated Nutrient SensingMoreover, kallistatin administration attenuated STZ-induced aortic senescence, oxidative stress, and miR-34a and miR-21 synthesis, and increased SIRT1, eNOS, and catalase levels in diabetic mice.28544111
Dyslipidemias, ObesityDeregulated Nutrient SensingOur results suggest that the components related to the metabolism of glucose and to high blood pressure appear early on and act as biomarkers for predicting MS, while the components related to obesity and dyslipidaemia, although essential for the development of MS, appear later.28545089
Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease)Deregulated Nutrient SensingParticulate air pollution induced changes in cord plasma insulin levels during early life and might be a risk factor in the development of metabolic disease, such as glucose intolerance or type 2 diabetes, later in life.28545656
Prostate Cancer Outcomes Study, Obesity, Abdominal, Dyslipidemias, HyperandrogenismDeregulated Nutrient SensingOur findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long-term health of women with PCOS.28546543
Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, ObesityDeregulated Nutrient SensingOverconsumption of dietary sugars, fructose in particular, is linked to cardiovascular risk factors such as type 2 diabetes, obesity, dyslipidemia and nonalcoholic fatty liver disease.28548281
Muscle damage, Inflammation, OverweightDeregulated Nutrient SensingMuscle damage derived from overweight displayed by oxidative and endoplasmic reticulum (ER) stress induces inflammation and insulin resistance and forces the muscle to increase requirements from autophagy mechanisms.28549989
Alzheimers DiseaseDeregulated Nutrient SensingApomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer's Disease.28550243
Data types - AddressDeregulated Nutrient SensingThus, brain insulin resistance is considered an important therapeutic target in AD, and APO may provide improved neuronal insulin resistance.28550243
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingAlzheimer's disease (AD) may have heterogeneous pathophysiological underpinnings, with risk factors including apolipoprotein rmvarep4 (APOE4) genotype and insulin resistance.28550261
Inflammation, IntestinesDeregulated Nutrient SensingMice with intestinal deletion of SIRT1 (SIRT1 iKO) had abnormal activation of Paneth cells starting at the age of 5-8 months, with increased activation of NF-kB, stress pathways, and spontaneous inflammation at 22-24 months of age, compared with control mice.28552621
ColitisDeregulated Nutrient SensingMoreover, SIRT1 iKO mice with defective gut microbiota developed more severe colitis than control mice.28552621
Ulcerative ColitisDeregulated Nutrient SensingIntestinal tissues from patients with ulcerative colitis expressed significantly lower levels of SIRT1 mRNA than controls.28552621
Inflammation, ColitisDeregulated Nutrient SensingIntestinal tissues from SIRT1 iKO mice given antibiotics, however, did not have signs of inflammation at 22-24 months of age, and did not develop more severe colitis than control mice at 4-6 months.28552621
Gastrointestinal inflammation, ColitisDeregulated Nutrient SensingIn analyses of intestinal tissues, colitis induction, and gut microbiota in mice with intestinal epithelial disruption of SIRT1, we found this protein to prevent intestinal inflammation by regulating the gut microbiota.28552621
CDISC Integrated Basic Data Structure DatasetDeregulated Nutrient SensingAgents designed to activate SIRT1 might be developed as treatments for IBDs.28552621
OsteolysisDeregulated Nutrient SensingVarious pathways in multiple cell types contribute to the pathogenesis of osteolysis, but the role of Sirtuin 1 (SIRT1), which can regulate inflammatory responses through its deacetylation, has never been investigated.28553103
Failure, OsteolysisDeregulated Nutrient SensingWe hypothesized that the downregulation of SIRT1 in macrophages induced by metal nanoparticles was one of the reasons for osteolysis in THA failure.28553103
OsteolysisDeregulated Nutrient SensingPharmacological activation of SIRT1 dramatically reduced the particle-induced expression of inflammatory cytokines in vitro and osteolysis in vivo.28553103
ObesityDeregulated Nutrient SensingVaspin may play an important compensatory role in obesity and insulin resistance in elderly people.28553648
Nonalcoholic Steatohepatitis, Carotid Intima-Media Thickness, Atherosclerosis, Fibrosis Assessment, Diabetes Mellitus, Dental Plaque, Fatty Liver DiseaseDeregulated Nutrient SensingWe collected anthropometric, clinical, and biochemical data, as well as information on carotid atherosclerosis (artery intima-media thickness and plaque), liver histology (nonalcoholic steatohepatitis [NASH] and fibrosis), insulin resistance, and diabetes.28554682
Hypertension, CTCAEDeregulated Nutrient SensingOur study suggests that OHT is associated with insulin resistance syndrome and onset of sustained arterial hypertension in normotensive, newly diagnosed diabetics.28554697
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPolyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases.28555039
SarcopeniaDeregulated Nutrient SensingWe tested the hypothesis that lifelong inhibition of the classical NFkB pathway would protect against aging-related sarcopenia and insulin resistance.28556540
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingHigh calf circumference is significantly associated with elevated prevalence of NAFLD and increasing insulin resistance.28558676
ObesityDeregulated Nutrient SensingIt appears that orally administered H2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity.28560519
Dyslipidemias, Diabetes Mellitus, Cerebrovascular accidentDeregulated Nutrient SensingHigh blood pressure, low socioeconomic status, dyslipidemia, diabetes, and family history of stroke were observed to be statistically significant risk factors for IS.28562233
HypoglycemiaDeregulated Nutrient SensingShe subsequently developed signs of insulin resistance and severe hypoglycemia, which was found to be due to insulin-receptor autoantibodies.28562254
Metabolic Diseases, Increased insulin level, Hypoglycemia, Diabetes MellitusDeregulated Nutrient SensingThis condition, known as type B insulin resistance, is a rare, heterogeneous metabolic disease that may feature hypoglycemia in the setting of extreme insulin resistance and hyperinsulinemia and, in this case, masqueraded as type 1 diabetes mellitus.28562254
Diabetes Mellitus, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases.28565926
Hypertension, CTCAE, Demographics Domain, DyslipidemiasDeregulated Nutrient SensingChi-square test was performed to compare gender, smoker rate, prevalence of DM, hypertension and dyslipidemia and edentulous rate.28567552
helium, DyslipidemiasDeregulated Nutrient SensingMore patients with HE had dyslipidemia than those with HU (58% vs. 38%).28569557
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingAcute BP elevations are associated with hyperglycemia, dyslipidemia, and higher potassium and creatinine levels and lower renal function.28569557
Fatty Liver DiseaseDeregulated Nutrient SensingImportantly, it suggests that NASH may be one of the early complications of T2DM due to its pathophysiological correlation with insulin resistance.28570615
Dyslipidemias, Psoriasis, Metabolic Syndrome XDeregulated Nutrient SensingPsoriasis is associated with dyslipidemia and metabolic syndrome, and has been linked to an increased cardiovascular risk.28573499
Inflammation, ObesityDeregulated Nutrient SensingImpacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood.28575103
InflammationDeregulated Nutrient SensingOur study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population.28575103
Inflammation, ObesityDeregulated Nutrient SensingConcomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance.28575103
Cessation of life, Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingDyslipidemia is one of the major risk factors for atherosclerosis and the main cause of death in the developing and developed countries.28576562
Parkinson DiseaseDeregulated Nutrient SensingSIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.28578695
Parkinson Disease, Neurodegenerative DisordersDeregulated Nutrient SensingSIRT1, the best studied mammalian SIRT is involved in many physiological and pathological processes and changes in SIRT1 have been implicated in neurodegenerative disorders, with SIRT1 having a suggested protective role in Parkinson's disease.28578695
Cessation of lifeDeregulated Nutrient SensingOver-expression of SIRT1 protected SH-SY5Y cells from toxin induced cell death and the protection conferred by SIRT1 was partially independent of its deacetylase activity, which was associated with the repression of NF-kB and cPARP expression.28578695
Parkinson Disease, Lewy Bodies, "Alzheimers Disease", Presenile dementiaDeregulated Nutrient SensingIn post-mortem brain tissue obtained from patients with Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies and Alzheimer's disease, the activity of SIRT1 was observed to be down-regulated.28578695
Neurodegenerative DisordersDeregulated Nutrient SensingThese findings suggests a negative effect of oxidative stress in neurodegenerative disorders and possibly explain the reduced activity of SIRT1 in neurodegenerative disorders.28578695
Canada, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe insulin resistance (IR) itself is bidirectionally associated with increased risk of type 2 diabetes mellitus (T2DM) and CAN is a predisposing factor.28581270
Dyslipidemias, Premature coronary artery atherosclerosisDeregulated Nutrient SensingIn this group, prevalence of dyslipidemia, smoking and family history of premature coronary artery disease (CAD) was higher, while the other classical risk factors were lower when compared to the old patients.28585049
Adrenal Gland NeoplasmsDeregulated Nutrient SensingThere was no significant correlation between fasting glucose, insulin resistance indices, and adrenal tumour size or degree of cortisol secretion.28585681
Degenerative polyarthritisDeregulated Nutrient SensingUnderlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes.28586000
Hypertension, CTCAEDeregulated Nutrient SensingNocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure.28586418
Hypertension, CTCAEDeregulated Nutrient SensingThere were no significant differences among the levels of insulin resistance markers between individuals with or without diurnal hypertension.28586418
Hypertensive (finding), Hypertension, CTCAE, ObesityDeregulated Nutrient SensingNocturnal but not diurnal hypertension was related to higher levels of 3 insulin resistance markers in normotensive and untreated mildly hypertensive adults; this relationship seems partially independent of obesity.28586418
Dyslipidemias, ObesityDeregulated Nutrient SensingThese ethnic groups showed increased prevalence of dyslipidemia, obesity, and much greater abnormalities asunique risk.28586605
Dyslipidemias, Hypertension, CTCAE, Sarcopenia, Diabetes MellitusDeregulated Nutrient SensingHigh-risk drinking is also closely related to diabetes, hypertension, and dyslipidemia, which are modifiable risk factors for sarcopenia.28590346
palladium, Communicable Diseases, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingHbA1c, dyslipidemia, hypertension, PD and duration of the procedure were predictive of infection complications (p < 0.05).28590832
Diabetes MellitusDeregulated Nutrient SensingA low insulinogenic index (IGI) level, but not insulin resistance, was a significant determinant of developing diabetes in subjects who had baseline KDS < 5.28591043
DyslipidemiasDeregulated Nutrient SensingThe sample consisted of 60,202 individuals who reported a medical diagnosis of dyslipidemia.28591319
Cessation of life, Dyslipidemias, Coronary heart diseaseDeregulated Nutrient SensingThe importance of dyslipidemia awareness in the present Brazilian epidemiological context must be emphasized to guide actions to control and prevent coronary heart disease, the leading cause of death in Brazil and worldwide.28591319
Tuberous SclerosisDeregulated Nutrient SensingHere we showed that BRSK2, a serine/threonine-protein kinase of AMPK family, was induced by nutrient deprivation in PDAC cells and suppressed mTORC1 activity via phosphorylation of tuberous sclerosis complex 2 (TSC2).28591720
ARCN1 gene, Chronic Obstructive Airway Disease, Sleep Apnea SyndromesDeregulated Nutrient SensingIn multivariate analysis, SteatoTest and FibroTest were significantly associated with sex, body mass index (BMI), untreated sleep apnoea and insulin resistance, and, in addition, COPD Global Initiative for Chronic Obstructive Lung Disease stage for SteatoTest.28596431
Ischemic strokeDeregulated Nutrient SensingIGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.28596451
Malignant NeoplasmsDeregulated Nutrient SensingTAK-228 (formerly MLN0128), an investigational dual TORC1/2 inhibitor plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies.28601972
Malignant NeoplasmsDeregulated Nutrient SensingThis phase I trial evaluated the safety, pharmacokinetic profile, and antitumor activity of investigational oral TORC1/2 inhibitor TAK-228 plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies.28601972
Glucose Intolerance (disease), Data types - AddressDeregulated Nutrient SensingOur findings suggest that elevated GA/HbA1c ratio-but not HbA1c, GA, or 1,5-AG level-is significantly associated with the risk of AD in subjects both with and without glucose intolerance.28605542
Diabetes MellitusDeregulated Nutrient SensingImpaired nutrient sensing and dysregulated glucose homeostasis are common in diabetes.28606928
Prediabetes syndrome, DyslipidemiasDeregulated Nutrient SensingBlood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia.28609607
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPrediabetes often occurs together with dyslipidaemia, which is paradoxically treated with statins predisposing to type 2 diabetes mellitus.28609607
Prediabetes syndrome, DyslipidemiasDeregulated Nutrient SensingBlood cell gene expression profiles differ significantly between prediabetic subjects with and without dyslipidaemia.28609607
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria.28610915
DyslipidemiasDeregulated Nutrient SensingHomocysteine level is worsened by increasing insulin resistance, dyslipidaemia and poor glucose control.28610915
Pancreatitis, Dyslipidemias, Cardiomyopathies, AtherosclerosisDeregulated Nutrient SensingOther organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis.28614536
ObesityDeregulated Nutrient SensingThe associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country.28617856
ObesityDeregulated Nutrient SensingVDR BsmI polymorphism was significantly associated with vitamin D deficiency and insulin resistance, but not with obesity in this population.28617856
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a major modifiable risk factor for cardiovascular disease.28620070
Hypertension, CTCAE, Ischemic stroke, DyslipidemiasDeregulated Nutrient SensingHypertension (67%), dyslipidemia (45%), and ischaemic stroke (32%) were the most common co-morbid conditions in the hospital cohort of patients.28622547
Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes MellitusDeregulated Nutrient SensingHypertension, diabetes, dyslipidaemia, and obesity, but not smoking were strong predictors of PAD.28623035
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingPrevalence and treatment of atherogenic dyslipidemia in the primary prevention of cardiovascular disease in Europe: EURIKA, a cross-sectional observational study.28623902
DyslipidemiasDeregulated Nutrient SensingAtherogenic dyslipidemia is associated with poor cardiovascular outcomes, yet markers of this condition are often ignored in clinical practice.28623902
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingA considerable proportion of patients with at least one major cardiovascular risk factor in the primary cardiovascular disease prevention setting have markers of atherogenic dyslipidemia.28623902
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingThe final sample included 49 sedentary men and women, who were non-smokers, with dyslipidaemia, overweight, and type1 obesity.28625710
Lupus Erythematosus, SystemicDeregulated Nutrient SensingHigh mTORC1 activation was noted in CD19+ B cells of patients with SLE and correlated with plasmablast differentiation and disease activity.28626065
Diabetes Mellitus, Insulin-DependentDeregulated Nutrient SensingThe aim of our study was to develop novel, accurate machine learning-based methods of insulin resistance estimation in children with type 1 diabetes.28626972
Dyslipidemias, Units Of Measure - SiemensDeregulated Nutrient SensingThe MAO and MADO groups showed higher blood pressure, atherogenic dyslipidemia, insulin resistance and inflammatory profile than that of MHO subjects.28630460
DyslipidemiasDeregulated Nutrient SensingSome simple anthropometric measurements such as body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), may link to increased risk of dyslipidemia.28632766
Hypercholesterolemia, CD55 gene, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe overall prevalence of high TC, high LDL-C, low HDL-C, hypercholesterolemia, hypertriglyceridemia and dyslipidemia were 15.68%, 27.98%, 20.12%, 44.01%, 21.98% and 49.06% respectively.28632766
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingMultiple logistic regressions showed only BMI (per quartile increment) increased risks for prevalent high LDL-C, low HDL-C, hypercholesterolemia, hypertriglyceridemia, and dyslipidemia.28632766
Hypercholesterolemia, Dyslipidemias, Metabolic Syndrome XDeregulated Nutrient SensingRegardless of sex, age and prevalent metabolic syndrome, increasing BMI was persistently independent risk factor for having low HDL-C, hypercholesterolemia and dyslipidemia, however was not associated with high TC.28632766
DyslipidemiasDeregulated Nutrient SensingIn non-obese Chinese population aged more than 40 years, increasing BMI may better identify the prevalent dyslipidemia than other anthropometric measurements.28632766
HD Term TypeDeregulated Nutrient SensingRecent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD.28632780
Diabetes MellitusDeregulated Nutrient SensingLipoprotein(a)-activated immunity, insulin resistance and new-onset diabetes.28633585
Diabetes MellitusDeregulated Nutrient SensingWe aimed to determine in nondiabetic people the relationship of serum [Lp](a) with insulin resistance and new-onset diabetes (NOD).28633585
Inflammation, Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingThe pathogenesis of non-alcoholic fatty liver disease (NAFLD) is attributed to a "multi-hits hypothesis" involving insulin resistance, oxidative stress and inflammation.28637594
InflammationDeregulated Nutrient SensingThe underlying mechanisms may be partly attributed to the interactions between insulin resistance, oxidative stress, inflammation, and DPP4.28637594
Glucose Intolerance (disease), SarcopeniaDeregulated Nutrient SensingTreatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid.28638045
Glucose Intolerance (disease), SarcopeniaDeregulated Nutrient SensingIn these ways, muscle mitochondrial activation with ALA is suggested to be useful for the treatment of sarcopenia and glucose intolerance.28638045
Cardiac complication, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWhether regulating apoC-III metabolism may be an important new therapeutic approach to managing dyslipidemia and microvascular complications in T2D remains to be proven in future mechanistic and clinical studies.28641786
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMultiple regression analysis indicated that cIABPDsys was associated with the Gensini score, independently of age, gender, smoking, diabetes, hypertension and dyslipidemia (B = 0.031, p < 0.001).28645074
Calcification of coronary arteryDeregulated Nutrient SensingRelationship between simple markers of insulin resistance and coronary artery calcification.28652190
Coronary Arteriosclerosis, Congenital AbnormalityDeregulated Nutrient SensingInsulin resistance in apparently healthy persons is associated with a cluster of metabolic abnormalities that promote coronary atherosclerosis.28652190
TG gene, SLC25A20 gene, Prediabetes syndromeDeregulated Nutrient SensingWe hypothesized that combining 2 simple markers of insulin resistance, prediabetes (PreDM) and triglyceride (TG) concentration >=150 mg/dL, would identify apparently healthy persons with adverse cardiometabolic risk profiles and increased coronary artery calcium (CAC) compared with those with neither or only 1 abnormality.28652190
TG geneDeregulated Nutrient SensingThe presence of 2 markers of insulin resistance, PreDM and TG concentration >=150 mg/dL, is associated with increased cardiometabolic risk and detectable CAC within a population of apparently healthy individuals.28652190
Impaired T cell function, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes mellitus (T2DM) is caused by insulin resistance and b cell dysfunction.28654680
Diabetes MellitusDeregulated Nutrient SensingAssociation of matrix g-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study.28654853
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThere is at present the dearth of information on the possible contribution of insulin resistance to scores obtained from mortality risk estimation in patients with type 2 diabetes mellitus (T2DM).28656934
Glucose Intolerance (disease)Deregulated Nutrient SensingEven if PSS are present, control of blood ammonia levels by BRTO alone may be difficult in patients with glucose intolerance.28657848
ObesityDeregulated Nutrient SensingPre-sarcopenia is associated with renal hyperfiltration independent of obesity or insulin resistance: Nationwide Surveys (KNHANES 2008-2011).28658107
ObesityDeregulated Nutrient SensingMultiple logistic regression analyses also demonstrated this independent association between pre-sarcopenia and renal hyperfiltration, following adjustment for confounding factors such as insulin resistance and obesity (OR = 1.84, 95% CI = 1.57-2.15, P < .001).In the general population of healthy individuals, pre-sarcopenia might be associated with renal hyperfiltration independent of obesity or insulin resistance.28658107
Hyperglycemia, ImpairedDeregulated Nutrient SensingIt is characterized by hyperglycemia, insulin resistance (IR), and relative impairment in insulin secretion.28658166
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThe prevalence of the distinct CVRFs was 35% for systemic hypertension, 17.5% for dyslipidemia, 17.5% for smoking, and 10% for type 2 diabetes mellitus.28662815
Memory impairmentDeregulated Nutrient SensingWe have previously shown that Ludwigia octovalvis extract (LOE) can significantly extend lifespan and improve age-related memory deficits in Drosophila melanogaster through activating AMP-activated protein kinase (AMPK).28666833
Diabetes MellitusDeregulated Nutrient SensingSince AMPK has become a critical target for treating diabetes, we herein investigate the anti-hyperglycemic potential of LOE.28666833
Hypertension, CTCAE, Atherosclerosis, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe adjusted odds ratios (aOR) for coronary atherosclerosis, hypertension, dyslipidaemia and diabetes were 7.97, 2.09, 2.48 and 1.51, respectively.28667203
palladium, DyslipidemiasDeregulated Nutrient SensingThe association of dyslipidemia with mortality has not been fully evaluated in patients on peritoneal dialysis (PD).28669685
Spinal Cord InjuriesDeregulated Nutrient SensingCutaneous microvascular perfusion responses to insulin iontophoresis are differentially affected by insulin resistance after spinal cord injury.28671307
Spinal Cord InjuriesDeregulated Nutrient SensingWhat impact does insulin resistance have on cutaneous perfusion responses to insulin iontophoresis in vascular beds with markedly reduced or functionally ablated sympathetic nervous system vasomotor function resulting from spinal cord injury?28671307
Spinal Cord InjuriesDeregulated Nutrient SensingPersons with spinal cord injury have sublesional microvascular endothelial dysfunction, as indicated by a blunted cutaneous perfusion response to acetylcholine iontophoresis, and the presence of insulin resistance has a further confounding effect on endothelium-mediated changes to cutaneous perfusion in the lower extremities.28671307
Stanford Cancer InstituteDeregulated Nutrient SensingThe effects of insulin resistance (IR) on sublesional cutaneous perfusion responses to insulin provocation have yet to be described in persons with SCI.28671307
Diabetes MellitusDeregulated Nutrient SensingAssociations of lipid parameters with insulin resistance and diabetes: A population-based study.28673690
Diabetes MellitusDeregulated Nutrient SensingThe present study aims to investigate associations of routine lipid profiles with insulin resistance and diabetes, respectively.28673690
TG gene, Diabetes MellitusDeregulated Nutrient SensingParticipants with insulin resistance or diabetes presented with significantly higher triglycerides (TG), Non-high-density lipoprotein cholesterol (Non-HDL-C), Non-HDL-C/HDL-C, TG/HDL-C and lower HDL-C when compared with control subjects (all P < 0.0001).28673690
TG gene, Diabetes MellitusDeregulated Nutrient SensingIn logistic regression analysis, subjects were more likely to have prevalent insulin resistance and diabetes with the elevated quartiles of TG, Non-HDL-C, Non-HDL-C/HDL-C and TG/HDL-C (all P < 0.05).28673690
Diabetes MellitusDeregulated Nutrient SensingTG/HDL-C ratio, compare with other lipid parameters, have shown the strongest correlation with increased odds of insulin resistance and diabetes.28673690
Diabetes MellitusDeregulated Nutrient SensingOur study suggests a discordant association of lipid parameters with blood glucose level and TG/HDL-C is a better marker for evaluating insulin resistance and diabetes in Chinese population when compared with other routine lipid measures.28673690
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingA dramatic gap exists between the clinical practice and guidelines for the dyslipidemia control in patients with diabetes.28673690
DyslipidemiasDeregulated Nutrient SensingInterventions in youth that address poor glycemic control and dyslipidemia may prevent or delay debilitating neuropathic complications.28674076
diabeticDeregulated Nutrient SensingOur data showed that Plasma CTRP1 was higher and negative correlation with insulin resistance in diabetic subjects (r = -0.283, p = 0.018).28674284
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPutting insulin resistance into context by dietary reversal of type 2 diabetes.28675193
Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIt has long been assumed that type 2 diabetes is caused by the combined effects of insulin resistance and loss of pancreatic islet beta cells.28675193
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingThe presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS.28675895
Cessation of life, Liver carcinomaDeregulated Nutrient SensingRegulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells.28676953
FAM126A geneDeregulated Nutrient SensingInterestingly, gallotannin attenuated the expression of SIRT1 and mTOR and activated phosphorylation of AMPK in two HCC cells.28676953
FAM126A geneDeregulated Nutrient SensingFurthermore, AMPK activator AICAR significantly enhanced SA-b-gal activity and antiproliferation induced by gallotannin, while AMPK inhibitor compound C did not in two HCC cells.28676953
Cessation of life, FAM126A geneDeregulated Nutrient SensingOverall, these findings highlight evidence that regulation of SIRT1/AMPK is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in HCC cells.28676953
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingKlotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients.28677090
Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney DiseasesDeregulated Nutrient SensingThe present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD.28677090
Injury of liver, hepcidin, HyperferritinaemiaDeregulated Nutrient SensingWhile hyperferritinaemia is associated with markers of liver injury and insulin resistance, serum hepcidin and hepatic iron are the strongest predictors of ferritin levels.28679028
Carcinoma of lungDeregulated Nutrient SensingImmunoblot analysis of the human normal appearing adjacent and lung cancer paired tissue lysates revealed cancer-specific MRS overexpression, which was related to mTORC1 activity.28679377
Osteoporosis, Dyslipidemias, Diabetes Mellitus, Hypothyroidism, Malignant Neoplasms, Hypertension, CTCAEDeregulated Nutrient SensingThe most frequently associated diseases were: hypertension, 29.8%; dyslipidemia, 27.1%; osteoporosis, 19.1%; diabetes, 12.4%; hypothyroidism, 6.2%; solid malignancies 4.4%.28681250
Primary malignant neoplasm, Breast CarcinomaDeregulated Nutrient SensingSit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.28682735
Fatty Liver, Inflammation, ObesityDeregulated Nutrient SensingThe inflammatory kinases IKKe and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation.28683283
ObesityDeregulated Nutrient SensingPositive Association of Obesity and Insulin Resistance With Bone Mineral Density in Tunisian Postmenopausal Women.28687244
ObesityDeregulated Nutrient SensingThe association of bone mineral density (BMD) with obesity and insulin resistance remains unclear.28687244
Diabetes MellitusDeregulated Nutrient SensingInsulin's microvascular action is impaired with insulin resistance and type 2 diabetes.28687542
Obesity, Bipolar DisorderDeregulated Nutrient SensingThe Relation of Light-to-Moderate Alcohol Consumption to Glucose Metabolism and Insulin Resistance in Nondiabetic Adults: the Moderating Effects of Depressive Symptom Severity, Adiposity, and Sex.28688095
Bipolar DisorderDeregulated Nutrient SensingWe examined the relation of alcohol consumption to glucose metabolism and insulin resistance (IR) as a function of depressive symptoms, adiposity, and sex.28688095
Diabetes MellitusDeregulated Nutrient SensingHCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes.28688190
DyslipidemiasDeregulated Nutrient SensingRisk factors associated with atherogenic dyslipidemia in the presence of optimal statin therapy.28689987
Dyslipidemias, Data types - AddressDeregulated Nutrient SensingBased on the Chinese guideline for the management of dyslipidemia, 13,551 patients reached LDL-C goals, and 7719 patients of them had AD.28689987
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThere was no difference in age at onset, sex, BMI and incidence of diabetes mellitus, hypertension or dyslipidemia.28691207
ETV3 wt AlleleDeregulated Nutrient SensingPatients with MetS were older and 49% had insulin resistance.28692538
Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Adenoma, Hypertension, CTCAEDeregulated Nutrient SensingAdvanced adenoma and cancer were significantly more frequent in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus (P = 0.019).28694666
Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Adenoma, Hypertension, CTCAEDeregulated Nutrient SensingAdvanced adenoma and cancer were more common in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus.28694666
Primary malignant neoplasm, Tuberous SclerosisDeregulated Nutrient SensingIncreased mTORC1 signaling from TSC1/TSC2 inactivation is found in cancer and causes tuberous sclerosis complex (TSC).28695825
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingA Tsc2/mTORC1 expression signature identified in Tsc2-deficient fibroblasts was also increased in bladder cancers with TSC1/TSC2 mutations in the TCGA database.28695825
Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Degenerative polyarthritis, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingObesity has become a major public health concern over the past several decades and has been shown to be associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, osteoarthritis (OA), and certain types of cancer.28695973
PeriodontitisDeregulated Nutrient SensingInvolvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross-sectional study.28696512
Periodontitis, ObesityDeregulated Nutrient SensingWe explored the association between obesity and periodontitis with the aim of determining the possible role of insulin resistance (IR) in this relationship.28696512
Increased insulin level, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe impact of parental history of type 2 diabetes on hyperinsulinemia and insulin resistance in subjects from central Mexico.28697997
Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, PathologyDeregulated Nutrient SensingHyperinsulinemia and insulin resistance are both associated with the development of Type 2 Diabetes and other pathologies; however, the influence of parental history of Type 2 diabetes (PH-T2D) has yet to be investigated.28697997
Increased insulin levelDeregulated Nutrient SensingLogistic regression was used to determine the association (odds ratio) between PH-T2D and hyperinsulinemia or insulin resistance.28697997
Increased insulin levelDeregulated Nutrient SensingSubjects having one or both parents were associated with an increase risk of developing hyperinsulinemia (odds ratio=1.53, 95%CI: 1.12-2.09, and odds ratio=1.92, 95%CI: 1.21-3.06, respectively) and insulin resistance (odds ratio=1.47, 95%CI: 1.08-2.00 and odds ratio=1.77, 95%CI: 1.09-2.87, respectively), when adjusting for age, sex, BMI, fasting plasma glucose, and triglycerides.28697997
Increased insulin levelDeregulated Nutrient SensingThe presences of PH-T2D significantly increased the risk of developing hyperinsulinemia and insulin resistance.28697997
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAssociation of divalent cations and insulin resistance with thyroid hormones in patients with type 2 diabetes mellitus.28701285
Dyslipidemias, Comorbidity, Diabetes MellitusDeregulated Nutrient SensingCorrelation among Glycemic control, Insulin resistance, Thyroid hormones, divalent cations and dyslipidemia depict differential characteristics in obese and non-obese type2 diabetes with Thyroid comorbidity.28701285
Obesity, HostilityDeregulated Nutrient SensingBecause obesity promotes insulin resistance and obese individuals tend to report higher levels of pessimism and cynical hostility, an interaction with body mass index (BMI) was explored.28703425
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingETV-treated patients were older (median age: 60 vs 55, P<.01), had similar smoking and hypertension rates, but diabetes and dyslipidemia were more prevalent (19% vs 9%, P=.01; 14% vs 6%, P=.05, respectively).28707319
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary Arteriosclerosis, Angina PectorisDeregulated Nutrient SensingOxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction.28707864
Primary malignant neoplasmDeregulated Nutrient SensingThe hypermethylated in cancer 1/sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin-induced damage-repair system.28708932
Acoma race, Aneurysm, DyslipidemiasDeregulated Nutrient SensingUnivariate analyses showed that the rate of IPR was significantly higher in the treatment of aneurysms with a small dome size, aneurysms in the anterior communicating artery (AcomA) (6.6%), and patients with a medical history of dyslipidemia.28710085
TG gene, Obesity, CD55 gene, Hypertension, CTCAE, OverweightDeregulated Nutrient SensingThese findings suggest that the mediators, insulin/insulin resistance, TG, TC, and FG, could be targeted for preventing hypertension among populations who were overweight or obesity.28710353
Coronary Artery DiseaseDeregulated Nutrient SensingGenetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.28714974
Coronary Artery DiseaseDeregulated Nutrient SensingPhenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.28714974
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension, dyslipidaemia, and cardiovascular risk in HIV-infected adults in Poland.28715065
Alzheimers DiseaseDeregulated Nutrient SensingIncreasing plasma glucose levels and insulin resistance can alter the distribution pattern of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) in the brain and relatively reduce 18F-FDG uptake in Alzheimer's disease (AD)-related hypometabolic regions, leading to the appearance of an AD-like pattern.28715453
Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Tacca leontopetaloidesDeregulated Nutrient SensingThere was also a significant increase in prevalence of hypertension (67.4% to 77.3%), structural heart disease (9.8% to 10.5%), and previous TIA (10.9% to 13.7%) and a significant decrease in prevalence of dyslipidemia (71.8% to 49.4%).28716216
Arteriosclerosis, DyslipidemiasDeregulated Nutrient SensingData were collected from the Dyslipidemia Registry of the Spanish Arteriosclerosis Society.28717233
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingComorbidities were also identified, such as diabetes, hypertension and dyslipidemia.28724036
Noncommunicable Diseases, Prediabetes syndromeDeregulated Nutrient SensingThe effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials.28724644
Noncommunicable Diseases, Prediabetes syndromeDeregulated Nutrient SensingMagnesium supplementation resulted in a mean reduction of 4.18 mm Hg in SBP and 2.27 mm Hg in DBP.Conclusion: The pooled results suggest that magnesium supplementation significantly lowers BP in individuals with insulin resistance, prediabetes, or other noncommunicable chronic diseases.28724644
Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes MellitusDeregulated Nutrient SensingThere was higher proportion of people with hypertension, diabetes mellitus, dyslipidaemia, and chronic kidney disease among people treated with VKA.28725983
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAs the second objective, to clarify the factors leading to this inverse association, the contribution of conventional risk factors, such as age, gender, hypertension, smoking, diabetes, obesity and dyslipidemia, to VHD and CAD were examined by multivariate analysis.28727835
Hypertensive disease, Dyslipidemias, Overweight, Diabetes MellitusDeregulated Nutrient SensingResults Among 200 patients (mean age 61.7 +- 9.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP.28728485
Arterial Stiffness, OverweightDeregulated Nutrient SensingRelationship between neck circumference, insulin resistance and arterial stiffness in overweight and obese subjects.28728486
Pre-Gestational DiabetesDeregulated Nutrient SensingFasting plasma glucose (FBG), insulin, insulin resistance, glycated haemoglobin and Human Placenta Lactogen(HPL)were significantly (p<0.0001) increased in the pregestational diabetic women whereas progesterone and estradiol were significantly decreased.28732072
Gestational DiabetesDeregulated Nutrient SensingIn the second trimester however, there was no significant difference (p>0.05) in estradiol, insulin, insulin resistance and HPL between the pregnant women who developed gestational diabetes and those who did not.28732072
deficiency aspects, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType II diabetes (T2D) is preceded by prolonged insulin resistance and relative insulin deficiency incompletely captured by glucose metabolism parameters, high-density lipoprotein (HDL) cholesterol and triglycerides.28733174
Fatty degeneration, ObesityDeregulated Nutrient SensingBITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance.28733781
Weight GainDeregulated Nutrient SensingBenzyl isothiocyante and S-carvone blocked high-fat diet-induced weight gain, fat accumulation in the liver, and insulin resistance.28733781
Polycystic Ovary Syndrome, ObesityDeregulated Nutrient SensingBioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: Relationships with obesity and insulin resistance.28734987
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingIn PCOS, total and free 25(OH)D were related to markers of insulin resistance and lipids.28734987
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingDBP was not associated with insulin resistance or BMI in PCOS.28734987
Increased insulin level, Infertility, Prostate Cancer Outcomes Study, Dyslipidemias, Subfertility, ObesityDeregulated Nutrient SensingIn several cases, PCOS women show infertility or subfertility and other metabolic alteration, such as insulin resistance (InsR), dyslipidaemia, hyperinsulinemia and obesity.28735644
Obesity, DysbiosisDeregulated Nutrient SensingDBZ is a putative PPARg agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis.28736228
Weight Gain, Steatohepatitis, InflammationDeregulated Nutrient SensingDBZ protects against HFD-induced body weight gain, insulin resistance, hepatic steatosis and inflammation in mice.28736228
Pain Distress Question, Inflammation, Diabetic Ketoacidosis, NephrolithiasisDeregulated Nutrient SensingNephrolithiasis can increase insulin resistance due to increased pain and inflammation, so these patients should be monitored closely for recurrence of DKA.28737266
Migraine Disorders, Prediabetes syndrome, Demographics DomainDeregulated Nutrient SensingInsulin resistance seems to exist in individuals with both migraine and prediabetes, and there is a possible negative association between DM and migraine.28738109
melanomaDeregulated Nutrient SensingSpecially, miR-23a-ATG12 axis attenuated melanoma invasion and migration through autophagy-mediated AMPK-RhoA pathway.28740547
Breast CarcinomaDeregulated Nutrient SensingInsulin resistance is associated with higher breast cancer (BC) penetrance in BRCA mutation carriers.28741383
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingCirculating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance.28743061
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe conclude that CTRP9 was strongly associated with insulin resistance, suggesting that CTRP9 might be important in the development of type 2 diabetes.28743061
Inflammation, AtherosclerosisDeregulated Nutrient SensingPeripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis.28743062
Inflammation, AtherosclerosisDeregulated Nutrient SensingGZB and PI-9 could be effective modulators for inflammation and insulin resistance in atherosclerosis.28743062
Dyslipidemias, Myocardial IschemiaDeregulated Nutrient SensingDyslipidemia and the use of statins was associated with culture establishment for IHD patients (p = 0.049 and p = 0.006, respectively).28743269
Perimenopausal state, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAEDeregulated Nutrient SensingAn educational intervention can be an effective method of reducing the parameters associated with an increased likelihood of cardiovascular disease in women at perimenopausal age with hypertension, diabetes mellitus and/or dyslipidaemia.28743399
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingPatients (n = 792) with NCCDs (obesity, systemic arterial hypertension, type 2 diabetes mellitus or dyslipidaemia) attended clinics of the public health service of the city of Uberlandia, Minas Gerais State, Brazil.28743872
Weight Gain, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingFactors associated with weight gain, hypertension and dyslipidaemias were analyzed.28750616
Weight Gain, DyslipidemiasDeregulated Nutrient SensingWeight gain, overweight/obese, older age, progression to post/peri-menopausal status at study entry, having received corticosteroid premedication before adjuvant chemotherapy and having received taxane-containing adjuvant chemotherapy were associated with increased risk of dyslipidaemias.28750616
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingFurther, a significant proportion of patients were detected to have hypertension and dyslipidaemias.28750616
Hepatitis CDeregulated Nutrient SensingLack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance.28753979
Hepatitis CDeregulated Nutrient SensingThe role of hepatitis C virus (HCV) in insulin resistance (IR) is not fully understood.28753979
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingDyslipidemia was significantly higher in ischemic stroke (OR = 2.65, 95% CI: 1.21-5.8).28756758
Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingThe conducted examinations indicated the contribution of adipocytokines-the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes.28758947
Steatohepatitis, ObesityDeregulated Nutrient SensingOur current data suggested that children with liver steatosis was highly associated with obesity, and insulin resistance.28759573
Sarcopenia, Cardiovascular DiseasesDeregulated Nutrient SensingSarcopenia, or loss of muscle mass, occurs with aging and results in frailty, disability, cardiovascular disease, and insulin resistance.28760192
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia tends to contribute to increased serum fructosamine concentrations in study population, suggesting that elevated serum fructosamine may herald an increased risk of cardiovascular disease among community-dwelling adults, especially in males.28761149
Inflammation, DyslipidemiasDeregulated Nutrient SensingThe LOX index is closely associated with smoking heaviness as well as dyslipidemia and an inflammation marker.28761986
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension (71%) and dyslipidaemia (62%) were common comorbidities.28764700
Prediabetes syndromeDeregulated Nutrient SensingVisceral adipose tissue is more strongly associated with insulin resistance than subcutaneous adipose tissue in Chinese subjects with pre-diabetes.28776439
Prediabetes syndromeDeregulated Nutrient SensingVAT was more strongly associated with insulin resistance than SAT in Chinese subjects with pre-diabetes.28776439
Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingInsulin resistance (IR), type 2 diabetes and the risk for development of cardiovascular disease was recently associated as an extended phenotype of the disease.28778179
DyslipidemiasDeregulated Nutrient SensingDyslipidemia was observed in 55.5% of the patients.28778179
Rheumatoid Arthritis, Cholelithiasis, Dyslipidemias, ComorbidityDeregulated Nutrient SensingHigh Prevalence of Gallstone Disease in Rheumatoid Arthritis: A New Comorbidity Related to Dyslipidemia?28778575
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingmTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingHowever, the effect of mTORC1 activation in epithelial cells on pterygium development has not yet been reported.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingAdditionally, the roles of mTORC1 in aberrant apoptosis and cell proliferation during the initiation of pterygium, and the underlying mechanisms, are not known.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingThe results revealed that mTOR signalling, especially mTORC1 signaling, is highly activated, and aberrant apoptosis and cell proliferation were observed in pterygium.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingmTORC1 activation inhibits apoptosis in pterygium by regulating Beclin 1-dependent autophagy via targeting Bcl-2.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingmTORC1 also negatively regulates fibroblast growth factor receptor 3 (FGFR3) through inhibition of p73, thereby stimulating cell proliferation in pterygium.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingThese data demonstrate that mTORC1 signalling is highly activated in pterygium and provide new insights into the pathogenesis and progression of pterygium.28779179
Pterygium Of Conjunctiva And CorneaDeregulated Nutrient SensingHence, mTORC1 may be a novel therapeutic target for the treatment of pterygium.28779179
ARCN1 gene, Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingAt multiple regression analysis the presence of dyslipidemia, COPD and AH were associated with the presence of endothelial dysfunction.28779547
DyslipidemiasDeregulated Nutrient SensingUrbanization, mainly rurality, but not altitude is associated with dyslipidemia profiles.28780399
Low-Density Lipoproteins, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe outcomes of interest were 6 dyslipidemia traits: hypertriglyceridemia, high low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol (HDL-c), nonisolated low HDL-c, isolated low HDL-c, and high non-HDL-c.28780399
DyslipidemiasDeregulated Nutrient SensingThe most common dyslipidemia pattern was high non-HDL-c with a prevalence of 88.0% (95% CI: 84.9%-90.7%) in the rural area and 96.0% (95% CI: 94.5%-97.1%) in the semi-urban area.28780399
DyslipidemiasDeregulated Nutrient SensingUrbanization but not altitude was associated to several dyslipidemia traits, with the exception of high non-HDL-c in high altitude settings.28780399
Infarction, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe PSR group also had more diabetes, dyslipidemia, smoking, infarcts from small-vessel disease, and "other definite" causes and worse onset NIHSS scores.28783808
Cataract, Glucose Intolerance (disease)Deregulated Nutrient SensingConsidering his glucose intolerance and cataracts as complications of corticosteroid treatment, administration of pirfenidone was initiated with the patient's consent.28784103
RETINOSCHISIS 1, X-LINKED, JUVENILE, Reed-Sternberg CellsDeregulated Nutrient SensingAberrant distributions of SIRT1, SIRT4, and SIRT6 were detected in Hodgkin neoplastic Reed-Sternberg (RS) cells compared with reactive elements.28786706
RETINOSCHISIS 1, X-LINKED, JUVENILE, CarcinogenesisDeregulated Nutrient SensingExpression levels of SIRT1, 4, and 6 were abnormally distributed in RS cells, suggesting a putative role of aberrant acetylation in classical HL carcinogenesis.28786706
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe association of anthropometric indicators with hypertension and dyslipidemia showed heterogeneous results.28789915
Squamous cell carcinoma of esophagusDeregulated Nutrient SensingFurthermore, MACC1 knockdown inactivated AMPK-ULK1 signaling pathway, and metformin could rescue MACC1-induced autophagy in ESCC cells.28791376
Squamous cell carcinoma of esophagus, Neoplasm MetastasisDeregulated Nutrient SensingCollectively, this study found that upregulation of MACC1 in ESCC was associated with lymph node metastasis of patients, and MACC1 regulated ESCC cell proliferation, apoptosis, migration and invasion mainly through AMPK-ULK1 induced autophagy.28791376
Peripheral Vascular Diseases, Blood coagulation, DyslipidemiasDeregulated Nutrient SensingEndovascular treatment with stenting in patients with atherosclerotic peripheral arterial disease is effective, but the risk of primary patency loss was affected by the presence of dyslipidemia, age, and blood coagulation parameters.28791851
Chronic cholecystitis, Cerebral Infarction, Presenile dementia, Dyslipidemias, EpilepsyDeregulated Nutrient SensingShe was hospitalized with an old cerebral infarction complicated with symptomatic epilepsy, dementia, dyslipidemia, and chronic cholecystitis.28794360
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingDyslipidemia and hypertension were the most prevalent dyad among both men and women.28796598
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingDyslipidemia, hypertension, and diabetes were the most prevalent triad among both men and women.28796598
ObesityDeregulated Nutrient SensingObesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10-4.72).28797289
Obesity, Diabetes MellitusDeregulated Nutrient SensingInsulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity.28797289
CholelithiasisDeregulated Nutrient SensingThe association between BMI and gallstone disease was explained by insulin resistance.28799434
Inflammation, Cholelithiasis, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingBiomarkers of insulin resistance, systemic inflammation and genetic obesity or type 2 diabetes risk alleles seem to be associated with gallstone disease.28799434
Cardiovascular DiseasesDeregulated Nutrient SensingRelationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon.28801428
HIV InfectionsDeregulated Nutrient SensingThe relationship between cardiovascular risk and insulin resistance in black African patients with HIV infection seems to depend on the cardiovascular risk equation used.28801428
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingThe rates of obesity, dyslipidemia, and diabetes showed partial statistical difference between the two groups.28803419
Inflammation, Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD) affects 20%-30% of adults with risk factors like obesity and insulin resistance putatively acting through chronic low-grade inflammation.28804947
Diabetes MellitusDeregulated Nutrient SensingWhen ATM gene is mutated, this event appears to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM).28806901
Chronic Kidney Insufficiency, DyslipidemiasDeregulated Nutrient SensingCompared with nonoctogenarians, we observed higher prevalence of dyslipidemia (P = 0.02), and chronic renal insufficiency (P = 0.02) during follow-up.28807220
Malignant neoplasm of skin, Dyslipidemias, Kidney FailureDeregulated Nutrient SensingFor those surviving into their 80s, cardiac function is preserved but dyslipidemia, renal insufficiency, and skin cancers are common.28807220
Primary malignant neoplasmDeregulated Nutrient SensingMany investigators have examined the functions of AMP-activated protein kinase (AMPK) in cancer biology and its anti-neoplastic features in cancer models.28807345
Breast CarcinomaDeregulated Nutrient SensingAMPK expression patterns are significantly associated with poor prognosis in breast cancer patients.28807345
Breast CarcinomaDeregulated Nutrient SensingThe goal of this research is to assess the association of the immunohistochemical expression of AMPK in human mammary tumours with the clinical data of breast cancer patients.28807345
Breast CarcinomaDeregulated Nutrient Sensing449 cases of previously diagnosed breast cancer, and 27 tissue samples of fibroadenomas and normal breast were utilized for detection of AMPK expression using tissue microarrays and immunohistochemistry.28807345
Primary malignant neoplasmDeregulated Nutrient SensingBrownish nuclear and cytoplasmic staining were present in epithelial cells and stromal cells in 333 (74.16%) and 348 (77.5%) cancer cases respectively indicating AMPK expression.28807345
Breast CarcinomaDeregulated Nutrient SensingSignificant statistical association has been found between advanced stages of breast cancer and increased intensity of AMPK immunostaining only in epithelial cells (p-value=0.0001).28807345
Noninfiltrating Intraductal CarcinomaDeregulated Nutrient SensingLow AMPK immunostaining scores were more dominant in DCIS, ductal and mixed type's ductal and mucinous histotypes, while high intense staining was more common in the lobular type.28807345
Mammary Neoplasms, P-ValueDeregulated Nutrient SensingFurthermore, breast tumour cases with lymph node metastases showed significant AMPK expression in both epithelial and stromal cells (p-value=0.0001 and p-value=0.026).28807345
Breast CarcinomaDeregulated Nutrient SensingLow scores of AMPK immunostaining were common in breast cancer cases with positive vascular invasion (p-value=0.007) and disease recurrence (p-value=0.008).28807345
Breast CarcinomaDeregulated Nutrient SensingIn conclusion, our results showed decreased AMPK expression in breast cancer in comparison with the control group.28807345
Vascular Invasion AssessmentDeregulated Nutrient SensingAMPK expression was significantly correlated with some clinicopathological factors like advanced stage, lymph node involvement, vascular invasion and disease recurrence which give indications for poor clinical outcomes.28807345
Breast CarcinomaDeregulated Nutrient SensingImmunohistochemical staining of AMPK protein is a valuable method which could predict cases of breast cancer with poor prognosis.28807345
Hypertension, CTCAE, HyperuricemiaDeregulated Nutrient SensingTemporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension.28808071
Hypertension, CTCAE, HyperuricemiaDeregulated Nutrient SensingAlthough hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown.28808071
Hypertensive (finding)Deregulated Nutrient SensingThe path coefficients from baseline uric acid to follow-up insulin resistance indices in the hypertensive group were significantly greater than that in the normotensive group (P<0.001 for the difference of b1 values in the 2 groups).28808071
Hypertension, CTCAEDeregulated Nutrient SensingThese findings provide evidence that higher uric acid levels probably precede insulin resistance, and peripheral insulin resistance likely plays a more important role in the development of hypertension than hepatic insulin resistance does.28808071
Tuberculosis, Pulmonary, TuberculosisDeregulated Nutrient SensingThe association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study.28810840
TuberculosisDeregulated Nutrient SensingThe existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature.28810840
Obesity, Diabetes MellitusDeregulated Nutrient SensingThe mechanisms by which each respective isoform contributes to obesity and insulin resistance may reveal novel treatment strategies for diabetes.28811295
Cardiovascular DiseasesDeregulated Nutrient SensingBecause preterm birth (PT) increases the risk for cardiovascular diseases during neonatal period as well as at adulthood, we hypothesized that SIRT1 deficiency could control the biogenesis of microparticles as part of a senescence-associated secretory phenotype (SASP) of PT-ECFC and investigated the related molecular mechanisms.28811647
ObesityDeregulated Nutrient SensingExpanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey.28812029
ObesityDeregulated Nutrient SensingThis study aims to expand the evaluation of normal weight obesity (NWO) and its association with insulin resistance using an NHANES (1999-2006) sample of US adults.28812029
Dyslipidemias, Coronary Artery Disease, Electrocardiogram: left ventricle hypertrophy (finding), Hypertension, CTCAE, Overweight, Cardiac ArrhythmiaDeregulated Nutrient SensingOf the 137 elderly, the study found the following: women (75.9%); overweight (48.2%); obese (30.6%); increase in the index waist/hip (88.3%); dyslipidaemia (94.2%) and hypertension (91.2%); coronary artery disease (35.0%); and 27.7% with cardiac arrhythmia or left ventricular hypertrophy.28817241
HyperglycemiaDeregulated Nutrient SensingHyperglycemia and elevated insulin-resistance were associated with low TBS independently of bone turnover and pentosidine levels.28821456
Sleep Apnea, ObstructiveDeregulated Nutrient SensingIn addition, the risks for insulin resistance increased with OSAS severity without fully adjustment.28821856
Sleep Apnea, ObstructiveDeregulated Nutrient SensingAn OSAS x smoking interaction was found in insulin resistance after adjusting for potential confounding factors (p = 0.025).28821856
Sleep Apnea, ObstructiveDeregulated Nutrient SensingCessation of cigarette smoking may experience minor benefit for insulin resistance and lipid metabolism in patients with OSAS.28821856
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingArterial hypertension is a disease that often coexists with dyslipidemia.28822022
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHigher levels of eryptosis have not been described in patients with hypertension, dyslipidemia, or both combined.28822022
Hypertensive (finding), DyslipidemiasDeregulated Nutrient SensingMean [Ca2+]i in hypertensive patients was 100 and 200% higher, in patients without and with dyslipidemia, respectively, compared to normotensive patients.28822022
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe identified 168 women (20%) with hypertension, 64 (7.6%) with diabetes mellitus, and 98 (11.7%) with dyslipidaemia.28826038
TriglyceridesDeregulated Nutrient SensingHowever, after adjusting for different indicators of adiposity, insulin resistance remained independently associated and the association with hypertriacylglycerolaemia was lost after adjusting for central adiposity.28829285
DamageDeregulated Nutrient SensingGood results will be achieved by applying liraglutide in intervention with different phases of DN and DM patients, which cannot only regulate the gastrointestinal hormone levels and lower the blood sugar levels of patients, but can also reduce the insulin resistance and delay the process of renal damage.28829486
DyslipidemiasDeregulated Nutrient SensingLpa, dyslipidaemia and smoking were significantly higher (p=0.006, p<=0.0001 and p=0.001, respectively) in CAC+ patients.28830786
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn individuals with type 2 diabetes, Bmal1, Per1, Per2, Rev-erba, and Ampk increased (P < 0.05) after lunch on the YesB day.28830875
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingIn contrast, in individuals with type 2 diabetes, Per1, Per2, and Sirt1 only slightly, but significantly, decreased and Rora increased (P < 0.05) after breakfast.28830875
Obesity, Diabetes MellitusDeregulated Nutrient SensingAdiposity seems to be primarily responsible for an increase in inflammatory markers, leading through this mechanism to insulin resistance and increasing diabetes risk.28834086
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingIn multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia ( P < .001), chronic kidney disease ( P = .004), and transient transfection, nuclear factor k-Light-Chain-Enhancer of activated B (NF-kB) cultured endothelial cells ( P = .007) and was positively associated with height ( P = .008).28835113
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIncreasing evidence suggested that VLDL-C was known as a significant risk factor for atherosclerosis and had been recommended as a treatment target by current dyslipidemia guidelines.28836572
Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingFractional esterification rate of cholesterol in high-density lipoprotein (FERHDL) has been found to be closely correlated with atherosclerotic dyslipidemia, especially lipoprotein distributions, and is a potentially useful predictor for coronary heart disease (CHD).28836980
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingIt can lead to dyslipidemia and be the risk factor of cardiovascular disease due to low estrogen level.28838227
hepcidinDeregulated Nutrient SensingIt has been shown that hepcidin and YKL-40 levels change in persons with insulin resistance in different circumstances.28841871
HyperglycemiaDeregulated Nutrient SensingThe Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance-The Maastricht Study.28842522
Dyslipidemias, Breast Carcinoma, Diabetes MellitusDeregulated Nutrient SensingAccumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer.28842914
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingBy receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia).28843368
Proximal tubulopathy, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingIncreased uNGAL and uNCR may indicate early tubular damage, associated with dyslipidemia and worse diabetes control, especially in females with T2DM.28845433
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe risk of type 2 diabetes is increasing in teenage girls, and is associated with their greater insulin resistance (IR).28851041
Dyslipidemias, Hypertension, CTCAE, Sarcopenia, Diabetes MellitusDeregulated Nutrient SensingFurthermore, diabetes and hypertension, but not dyslipidemia, were found to be significantly associated with sarcopenia.28851881
Alzheimers Disease", Data types - AddressDeregulated Nutrient SensingExperimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer's disease (AD) pathological features.28852028
Hyperglycemia, ETV3 wt Allele, ObesityDeregulated Nutrient SensingThose who were uaHB had a higher risk of central obesity, hyperglycemia, insulin resistance, and MetS than those who were aHB (odds ratio = 2.33, 1.64, 2.15, 1.85, respectively, all p < 0.05).28852048
Bone necrosisDeregulated Nutrient SensingSIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.28856724
Osteonecrosis of JawDeregulated Nutrient SensingIn summary, we identified the SIRT1/HERC4 locus on chromosome 10 to be associated with iv BP-induced ONJ and two promoter SNPs that might be the potential genetic markers for this association.28856724
Glucose Intolerance (disease), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingDifferences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS.28860506
Chronic liver disease, Glucose Intolerance (disease)Deregulated Nutrient SensingGlucose intolerance frequently develops in accordance with the progression of chronic liver disease.28860506
Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease, Hepatitis C, ChronicDeregulated Nutrient SensingHowever, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood.28860506
Glucose Intolerance (disease), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn conclusion, obvious differences in the characteristics of glucose intolerance between patients with NAFLD and those with C-CH were clarified.28860506
Fibrosis, Liver, Glucose Intolerance (disease), Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingIn patients with NAFLD, glucose intolerance gradually progressed in accordance with the progression of hepatic fibrosis.28860506
Glucose Intolerance (disease), HypoalbuminemiaDeregulated Nutrient SensingIn those with C-CH, glucose intolerance suddenly developed upon the appearance of hypoalbuminaemia.28860506
Diabetic NephropathyDeregulated Nutrient SensingSIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy.28860538
Diabetic NephropathyDeregulated Nutrient SensingSIRT1 and FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN).28860538
Hepatitis CDeregulated Nutrient SensingInterferon-g-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response.28862188
Dyslipidemias, Cardiovascular systemDeregulated Nutrient SensingThe effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established.28863328
Anxiety, CTCAE 3.0, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHypertension (p < 0.001), diabetes (p < 0.05), dyslipidemia (p < 0.05), type-D personality (p = 0.001) and anxiety (p < 0.001) were more prevalent among patients.28865501
Anxiety, CTCAE 3.0, Acute Coronary Syndrome, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingType-D personality, high anxiety, hypertension and dyslipidemia seem to cluster among female acute coronary syndrome patients.28865501
Atrial Fibrillation by ECG FindingDeregulated Nutrient SensingThe association between insulin resistance and atrial fibrillation: A cross-sectional analysis from SPRINT (Systolic Blood Pressure Intervention Trial).28866864
Amyotrophic Lateral Sclerosis, DyslipidemiasDeregulated Nutrient SensingDyslipidemia has been described in ALS patients and may be protective but peripheral lipoprotein subclasses have never been studied.28870551
Amyotrophic Lateral Sclerosis, DyslipidemiasDeregulated Nutrient SensingOur preliminary work confirmed the association between ALS and dyslipidemia.28870551
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingA higher regional prevalence of hypertension, dyslipidaemia and lack of exercise may be responsible.28871014
Dyslipidemias, Hypertension, CTCAE, Benign Paroxysmal Positional Vertigo, Cardiovascular systemDeregulated Nutrient SensingThe presence of hypertension, dyslipidaemia and pre-existing cardiovascular comorbidities were significantly related to recurrent BPPV episodes (OR range between 1.84 and 2.31).28872163
Atrioventricular Block, Hypertrophic Cardiomyopathy, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingComplex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes.28874324
Cardiomyopathies, Dyslipidemias, Diabetes Mellitus, Lipodystrophy, No metabolic abnormalitiesDeregulated Nutrient SensingSome mutations, associated with lipodystrophy but not cardiomyopathy, have been linked to metabolic abnormalities such as diabetes and severe dyslipidemia.28874324
Atrioventricular Block, Hypertrophic Cardiomyopathy, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingHerein we describe a new phenotype associated with a mutation in exon 11 of the LMNA gene: hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes.28874324
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe thus investigated whether afamin concentrations are associated with prediabetes, type 2 diabetes, and insulin resistance (IR).28877915
Dyslipidemias, Chronic disease, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingYounger age, African American race, and chronic disease such as hypertension and dyslipidemia correlated with obesity.28880738
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThe prevalence of dyslipidemias, hyperglycemia, and insulin resistance were evaluated, together with the correlations of these variables with the increase of Z-BMI.28881179
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingOverweight and obesity give origin to a high prevalence of dyslipidemia and insulin resistance.28881179
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMetabolically healthy subjects were defined as those without hypertension, dyslipidemia and diabetes.28882469
Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Heart Diseases, Have, Hypertension, CTCAEDeregulated Nutrient SensingHAS patients were found to have many of the risk factors associated with cardiovascular disease (male sex, ageing, antecedent of cardiac disease, arterial hypertension, dyslipidaemia, smoking habit) and cancer.28882641
Dyslipidemias, AtherosclerosisDeregulated Nutrient SensingIn the subgroup analysis, the reduction in hard ASCVD events for NHCS participants was significantly greater in patients without a previous history of dyslipidemia or who did not have outpatient care.28886857
Chronic Kidney DiseasesDeregulated Nutrient SensingIn conclusion, insulin resistance was positively associated CKD with in Korean adults with or without T2DM.28890482
ObesityDeregulated Nutrient SensingFurther adjustment of mediators, such as central obesity or insulin resistance, attenuated the association to 1.91-2.17.28892211
Hyperandrogenemia, Inflammation, Hyperlipidemia, Cardiovascular Diseases, AtherosclerosisDeregulated Nutrient SensingChronic inflammation, insulin resistance, hyperandrogenemia, hyperlipidemia and increased oxidative stress are known to have a role in the formation of atherosclerosis and cardiovascular disease.28892255
DyslipidemiasDeregulated Nutrient SensingPrevious national survey suggested that dyslipidemia is an increasing burden in China and more severe in urban population.28895638
DyslipidemiasDeregulated Nutrient SensingDyslipidemia is an increasing epidemic in China, characterized by a rising trend of LDL cholesterol.28895638
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingThe gender and age differences in serum levels of lipid profile as well as prevalence of dyslipidemia suggested that the middle-age men and postmenopausal women should be the prioritized target for better control of dyslipidemia and early prevention of cardiovascular disease.28895638
Inflammation, Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRelationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus.28895641
Inflammation, square decimeter, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingConsidering the high prevalence of non-alcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2.28895641
Inflammation, Dyslipidemias, Diabetes Mellitus, Fatty Liver DiseaseDeregulated Nutrient SensingMultimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.28895641
Metabolic Syndrome XDeregulated Nutrient SensingRecent reports indicate that fasting glucose levels in non-diabetic patients correlate appropriately with the development of certain elements in metabolic syndrome, which suggest a cause-effect relationship with insulin resistance.28895791
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingWe explored whether growth differentiation factor 15 (GDF15) affects the histological severity of non-alcoholic fatty liver disease (NAFLD) independent of insulin resistance.28898507
Hyperglycemia, Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingA high prevalence of hypertension (51%), dyslipidemia (52%), elevated liver enzyme levels (51%), and hyperglycemia (24%) was found.28898874
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThis association was independent of hyperglycemia and dyslipidemia (p = 0.03).28898874
DyslipidemiasDeregulated Nutrient SensingQ1 also had higher frequency (+31%) and severity (+20%) of atherogenic dyslipidemia.28899393
Hypertension, CTCAEDeregulated Nutrient SensingHypertension and the triglyceride and glucose index both have been associated with insulin resistance; however, the longitudinal association remains unclear.28903774
Pain Distress Question, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingNevertheless, as compared to other populations, Mexican centenarians report having good self-perception of health (78.9%), polypharmacy (17.8%), low rate of pain (11.4%), diabetes (4.8%), and dyslipidemia (1.8%).28904969
Monogenic diabetes, diabeticDeregulated Nutrient SensingAtherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported.28913361
Myotonic DystrophyDeregulated Nutrient SensingReceptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle.28915272
Demographics DomainDeregulated Nutrient SensingWe have analysed the insulin pathway in skeletal muscle biopsies and in myotube cultures from DM patients to assess whether downstream metabolism might be dysregulated and to better characterize the mechanism inducing insulin resistance.28915272
Sepsis, vascular inflammations, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingPrevious work revealed a strong role for miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and cardiovascular disease.28916639
Impaired lung functionDeregulated Nutrient SensingYoung adults with preclinical insulin resistance have a higher risk of impaired lung function.28916790
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingRESULTS The comparison between the potential donors in Group A vs. Group B revealed an increase over time in donor age (54.6+-17.2 vs. 58.8+-16.3, p<0.001), a reduction in the percentage of standard donors (52.3% vs. 39.8%, p<0.001), a broader utilization of organs from expanded criteria donors, and a greater number of comorbidities, particularly cardiovascular disease and dyslipidemia.28919594
Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingAmong survivors only, preexisting cardiovascular factors (hypertension, dyslipidemia, and diabetes) and preexisting cardiovascular disease were ascertained.28922087
Prostate carcinomaDeregulated Nutrient SensingDiindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).28923415
Prostate carcinomaDeregulated Nutrient SensingAs DIM is a mitochondrial ATP-synthase inhibitor, we hypothesized that DIM and ring-DIMs induce autophagy via alteration of intracellular AMP/ATP ratios and activation of AMP-activated protein kinase (AMPK) signaling in prostate cancer cells.28923415
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingDietary sugars are linked to the development of non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia, but it is unknown if NAFLD itself influences the effects of sugars on plasma lipoproteins.28923880
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients with both hypertension and dyslipidemia have 4x higher annual progression rate compared with subjects without these risk factors (0.398 m/s/y versus 0.102 m/s/y).28923899
Obesity, Bipolar DisorderDeregulated Nutrient SensingWe estimated the association between obesity, insulin resistance, and depressive symptoms by carrying out univariate and multivariate regression analyses.28925048
Bipolar DisorderDeregulated Nutrient SensingOur results suggest that depressive symptoms are associated with insulin resistance in older Mexican-American adults.28925048
Inflammation, AtherosclerosisDeregulated Nutrient SensingIndividual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study.28928169
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe surgery group had higher remission rates and lower incidence rates of hypertension and dyslipidemia than did nonsurgery group 1 (P<0.05 for all comparisons).28930514
Rheumatoid ArthritisDeregulated Nutrient SensingInsulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass.28932748
Refractory anemias, Rheumatoid ArthritisDeregulated Nutrient SensingIn established rheumatoid arthritis (RA), the presence of insulin resistance (IR) is well proven but, in the early stage of the disease, data are inconclusive.28932748
Refractory Cytopenia of ChildhoodDeregulated Nutrient SensingSIRT1, SIRT3, and SIRT6 expression was significantly lower in RCC than in normal tissues (P = 0.001, P = 0.006, and P = 0.033, respectively), whereas the expression of other SIRT proteins did not differ significantly between the 2 tissues.28935184
Refractory Cytopenia of Childhood, NeoplasmsDeregulated Nutrient SensingOur results provide preliminary evidence suggesting that SIRT1, SIRT3, and SIRT6 function as tumor suppressors in RCC.28935184
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingGut bacterial translocation to the blood may play an important role in the development of insulin resistance in type 2 diabetes.28935921
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular DiseasesDeregulated Nutrient SensingObesity is associated with hypoadiponectemia, dyslipidemia, and increased risk of cardiovascular disease (CVD).28938424
Hypertension, CTCAEDeregulated Nutrient SensingFindings were confirmed in Hypertension Insulin-Resistance Study premenopausal women.28938457
ObesityDeregulated Nutrient SensingDoes Cardiorespiratory Fitness Attenuate the Adverse Effects of Severe/Morbid Obesity on Cardiometabolic Risk and Insulin Resistance in Children?28939688
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Prostate, Cessation of lifeDeregulated Nutrient Sensinganti-diabetes, anti-dyslipidaemia, and antihypertension) in relation to all-cause, cardiovascular disease (CVD), and prostate cancer-specific death were studied using multivariate Cox proportional hazard and Fine and Gray competing regression models.28940667
Hyperglycemia, Hypertension, CTCAE, Prostate carcinoma, DyslipidemiasDeregulated Nutrient SensingWe did not find evidence for a better or worse response to GnRH agonists in men with prostate cancer who were also on drugs for hypertension, dyslipidaemia, or hyperglycaemia.28940667
SteatohepatitisDeregulated Nutrient SensingTaken together, these findings suggest that BSE promotes degradation of lipid droplets and subsequent activation of fat oxidation by activating AMPK in the liver, thus protecting against development of hepatic steatosis in alcohol-fed mice.28941686
LIPC geneDeregulated Nutrient SensingSaponarin, a major flavonoid in BSE and an activator of AMPK, increased the activity of microsomal triglyceride transfer protein, which suggests that the reduction in hepatic triglyceride levels was mediated by this component of BSE.28941686
Malignant tumor of colonDeregulated Nutrient SensingLong non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA.28943452
Malignant tumor of colon, Neoplasm MetastasisDeregulated Nutrient SensingMoreover, HNF1A-AS1 functioned as an oncogene in metastasis of colon cancer in part through serving as a competing endogenous RNA to modulate miRNA-34a expression, subsequently with repression of miR-34a/SIRT1/p53 feedback loop and activation of canonical Wnt signaling pathway.28943452
Diabetes MellitusDeregulated Nutrient SensingThe Serum Level of KL-6 Is Associated with the Risk of Insulin Resistance and New-onset Diabetes Mellitus: The Tanno-Sobetsu Study.28943558
Chronic Obstructive Airway Disease, Pneumonitis, Diabetes MellitusDeregulated Nutrient SensingThe involvement of pulmonary inflammation in insulin resistance remains unclear, but smoking is known to be a risk factor for diabetes as well as chronic obstructive pulmonary disease.28943558
Diabetes MellitusDeregulated Nutrient SensingConclusion A modest elevation of the serum KL-6 level is therefore considered to be associated with the risk for insulin resistance development and new-onset diabetes mellitus in a general population.28943558
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance (IR) is known to be an important factor, which can lead to the onset of type 2 diabetes.28944847
Dyslipidemias, HypocholesterolemiaDeregulated Nutrient SensingAs genetics improved the predictive power of dyslipidemia development, only 24 patients need to be genotyped to prevent the development of one case of HDL hypocholesterolemia.28945215
muscle massDeregulated Nutrient SensingAfter therapy, homeostasis model assessment of insulin resistance, fasting insulin level, and insulin AUC decreased despite an increase in IHL and abdominal and thigh adipose tissues and a decrease in muscle mass.28945897
Increased insulin level, AcromegalyDeregulated Nutrient SensingPatients with acromegaly were characterized by insulin resistance and hyperinsulinemia but lower IHL compared with age-, BMI-, and sex-matched healthy controls.28945897
Acromegaly, muscle massDeregulated Nutrient SensingBiochemical control of acromegaly improved insulin resistance but led to a less favorable anthropometric phenotype with increased IHL and abdominal adiposity and decreased muscle mass.28945897
Inflammation, Insulin ResistanceDeregulated Nutrient SensingBoth insulin-resistance and chronic low-grade inflammation are involved in this relationship.28946871
Dyslipidemias, Congestive heart failure, malignant disease, Chronic Obstructive Airway Disease, Peripheral Vascular Diseases, Asthma, Chronic Kidney DiseasesDeregulated Nutrient SensingOther risk factors of 30-day readmission included female gender, emergency and urgent procedures, certain patient comorbidities (dyslipidemia, congestive heart failure, history of transient ischemic attack, previous cardiac surgery, chronic obstructive pulmonary disease, asthma, chronic kidney disease, peripheral vascular disease, and history of malignant disease), and hemorrhage/shock/bleeding occurring during the index admission as well as nonhome discharge.28947230
Metabolic Diseases, Noncommunicable Diseases, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of noncommunicable diseases, including those such as type 2 diabetes, obesity, dyslipidemia, and hypertension, so-called cardiometabolic diseases, is high and is increasing worldwide.28947415
Metabolic Diseases, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingWe conducted qualitative semistructured interviews in March to May 2016 with 11 senior physicians from a public university hospital in France with expertise in management of cardiometabolic diseases (type 1 and type 2 diabetes, obesity, hypertension, and dyslipidemia).28947415
Glucose Intolerance (disease), Injury of liverDeregulated Nutrient SensingThis study revealed a novel role of the OST48 and AGE axis in hepatic injury through ER stress, changes in fuel utilisation and glucose intolerance.28947796
Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingSerum uric acid (SUA) levels are associated with glucose intolerance and type 2 diabetes.28948573
Dyslipidemias, Gastroesophageal reflux disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, ComorbidityDeregulated Nutrient SensingAmong patients with obesity (BMI >=30 kg/m2), those coded for obesity were younger, more often female, and had a greater comorbidity burden than those not coded; hypertension, dyslipidemia, type 2 diabetes mellitus, and gastroesophageal reflux disease were the most common comorbidities.28949834
Diabetic Retinopathy, Dyslipidemias, GDC Disease Response TerminologyDeregulated Nutrient SensingResults from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent.28951389
Prediabetes syndrome, Diabetes MellitusDeregulated Nutrient SensingThe incidence of diabetes mellitus is rising worldwide, and prediabetic screening for insulin resistance (IR) has become ever more essential.28953643
Adenoma, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingF and E levels were similar among patients with unilateral or bilateral adenoma, or considering the presence of hypertension, dyslipidemia, diabetes, or cardiovascular events.28956262
Function (attribute)Deregulated Nutrient SensingFermented Rice Germ Extract Alleviates Morphological and Functional Damage to Murine Gastrocnemius Muscle by Inactivation of AMP-Activated Protein Kinase.28956710
Hernia of abdominal cavity, Gout, Dyslipidemias, Substance abuse problem, Diabetes Mellitus, Hepatobiliary DisorderDeregulated Nutrient SensingDiabetes, gout, dyslipidemia, abdominal hernia, liver disease, alcohol and tobacco use, and substance abuse were higher for men (P < 0.0001).28958273
Units Of Measure - Siemens, ObesityDeregulated Nutrient SensingMetabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) are differentiated by the presence of cardiometabolic risk factors (CMRFs) and insulin resistance (IR).28960038
diabeticDeregulated Nutrient SensingMany studies showed insulin resistance amelioration in HCV-patients achieving Sustained Virologic Response (SVR) but results on glycemic control in diabetic patients are unclear.28960353
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingActivating events along the PI3K/mTOR pathway are common in head and neck squamous cell carcinomas (HNSCC), and preclinical studies suggest additive or synergistic effects when combining mTORC1 inhibitors with carboplatin and paclitaxel chemotherapy.28961834
PARK7 geneDeregulated Nutrient SensingBecause aging is associated with deregulated nutrient sensing, these results help explain why DJ-1 is associated with age-dependent disease.28962651
Data types - AddressDeregulated Nutrient SensingThese results will help us to better understand the protective role of SIRT1 in AD, and they support the potential use of SIRT1 as a biomarker and drug target for the prevention, diagnosis, and treatment of AD as well as other relevant age-related diseases.28962864
Squamous cell carcinoma of the head and neckDeregulated Nutrient SensingPrognostic relevance of insulin resistance on disease-free survival in head and neck squamous cell carcinomas: Preliminary results.28963801
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThis may indicate that abnormalities in postprandial VLDL-TG metabolism are a consequence of obesity/insulin resistance more than a result of type 2 diabetes per se.28964326
Liver carcinomaDeregulated Nutrient SensingNegative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts.28964787
Liver carcinoma, FAM126A geneDeregulated Nutrient SensingWe showed here that persistent exposure to a low concentration of metformin led to AMPK activation in a mouse xenograft model of human hepatocellular carcinoma (HCC), resulting in senescence.28964787
FAM126A geneDeregulated Nutrient SensingTaken together, these findings suggest that a low dose of metformin could potentially be used as a TIS-inducing therapeutic drug for HCC, and that this occurs by inducing senescence of HCC cells via the AMPK-SIRT1 pathway.28964787
Hypertension, CTCAE, ras GTPase-Activating Proteins, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPreventive treatment gaps affected 14% of patients with hypertension, 36% of patients with dyslipidaemia and 32% of patients with diabetes.28965093
DyslipidemiasDeregulated Nutrient SensingFor patients with dyslipidaemia, the presence of a treatment gap was associated with a higher risk of an adverse event.28965093
SLC25A20 gene, DyslipidemiasDeregulated Nutrient SensingPrevious studies reporting that statin increases coronary artery calcium (CAC) were conducted exclusively on patients with statin as a prevention, regardless of the presence or absence of dyslipidemia.28966320
InflammationDeregulated Nutrient SensingAbout 900 DMRs were found and their associated genes were significantly enriched in 32 pathways, the top ones of which were associated with insulin resistance and inflammation.28967791
Primary malignant neoplasm, NeoplasmsDeregulated Nutrient SensingTaken together, our data demonstrate that deregulation of the PI3K-AKT/ mTORC1/ p70S6K pathways, an event frequently observed in cancer, exert profound effects on genome stability via MRE11 with potential implications for tumour initiation and therapy.28967905
Dyslipidemias, Gastroesophageal reflux disease, Acid reflux, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingRemission rates of co-morbidities were 83.5% for dyslipidemia (P < 0.001), 65.8% for hypertension (P < 0.001), 62.1% for type 2 diabetes mellitus (T2DM) (P < 0.001), and 60.7% for gastroesophageal reflux (GERD) (P < 0.001).28971291
Cardiac complication, Dyslipidemias, Endothelial dysfunctionDeregulated Nutrient SensingResearch of early predictors of cardiovascular complications: dyslipidemia, insulin resistance, inflammatory marker- C-reactive protein, marker of vascular aging-telomerase activity and marker of endothelial dysfunction (ED) - CDECs and VEGF-A that have been analyzed are on the front burner.28972487
Metabolic DiseasesDeregulated Nutrient SensingInsulin resistance is a major predictor of the development of metabolic disorders.28973648
ObesityDeregulated Nutrient SensingImportantly, we found that SIRT2 expression in PBMCs of human subjects was negatively correlated with obesity and insulin resistance.28973648
Diabetes MellitusDeregulated Nutrient SensingThese results suggest a novel function for hepatic SIRT2 in the regulation of insulin sensitivity and raise the possibility that SIRT2 activators may offer novel opportunities for preventing or treating insulin resistance and type 2 diabetes.28973648
Electrocardiogram: myocardial infarction (finding), Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingTo determine whether, among patients with an ischemic stroke or transient ischemic attack and insulin resistance, those at higher risk for future stroke or myocardial infarction (MI) derive more benefit from the insulin-sensitizing drug pioglitazone hydrochloride compared with patients at lower risk.28975241
Cerebrovascular accidentDeregulated Nutrient SensingA secondary analysis was conducted of the Insulin Resistance Intervention After Stroke trial, a double-blind, placebo-controlled trial of pioglitazone for secondary prevention.28975241
Ischemic strokeDeregulated Nutrient SensingEligible participants had a qualifying ischemic stroke or transient ischemic attack within 180 days of entry and insulin resistance without type 1 or type 2 diabetes.28975241
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingOnly 23.6% of patients reported to do regular exercise,73.4% had history of hypertension, 47.4% had dyslipidemia and 33.9% had diabetes mellitus.28980279
Hypertension, CTCAE, Ischemic stroke, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe risk of AF-associated MI was higher in patients free of hypertension, diabetes, ischemic stroke, and dyslipidemia at baseline.28983076
Inflammation, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingThis propensity to inflammation may be a driver of the higher risk of cardiovascular disease, insulin resistance and diabetes observed in this population.28987777
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe presence of diabetes mellitus, hypertension, and dyslipidemia was defined using the criteria of previous studies.28991084
Obesity, AtherosclerosisDeregulated Nutrient SensingRecent studies have shown that A-FABP is secreted by adipocytes and that the A-FABP concentration is associated with obesity, insulin resistance, and atherosclerosis.29017449
Malignant tumor of colonDeregulated Nutrient SensingAerobic exercise reduces insulin concentrations and insulin resistance among patients with stage I-III colon cancer.29018055
Malignant tumor of colonDeregulated Nutrient SensingPrescribing 150 min/week of aerobic exercise may be sufficient for reducing insulin concentrations and insulin resistance, which may partially mediate the relationship between physical activity and colon cancer prognosis.29018055
Dyslipidemias, Diabetes Mellitus, Heart Diseases, Tuberculosis, Pulmonary, Cerebrovascular accident, Hypertension, CTCAEDeregulated Nutrient SensingAgreement was excellent for hypertension and diabetes, fair to good for stroke and heart disease, and poor for pulmonary tuberculosis and dyslipidemia.29020761
Erectile dysfunction, GoutDeregulated Nutrient SensingInsulin resistance is an independent predictor of erectile dysfunction in patients with gout.29020765
Diabetic NephropathyDeregulated Nutrient SensingExtracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic Nephropathy.29020797
Sedentary lifestyle, ObesityDeregulated Nutrient SensingSedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status.29020958
Heart failure, CardiomyopathiesDeregulated Nutrient SensingWe found that Akt-mTORC1 (mammalian target of rapamycin complex 1) signaling was increased, and treatment with 2.24 mg/kg*d rapamycin or 40% caloric restriction for 9 weeks partially rescued cardiomyopathy or heart failure and restored autophagic flux in knockin mice.29021349
Drug abuse, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingUsing joinpoint regression, prevalence of hypertension increased annually by 1.4%, diabetes by 2%, dyslipidemia by 7%, smoking by 5%, and drug abuse by 7%.29021359
Postmenopausal stateDeregulated Nutrient SensingGenetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk.29023587
melanomaDeregulated Nutrient SensingMelanoma antigen A6 (MAGEA6)/TRIM28 complex is a cancer-specific ubiquitin ligase, which degradates tumor suppressor protein AMP-activated protein kinase (AMPK).29024810
Glioblastoma Multiforme PathwayDeregulated Nutrient SensingMAGEA6 knockdown by targeted-shRNA in glioma cells restored AMPKa1 expression, causing mTORC1 in-activation and cell death/apoptosis.29024810
methyldopa, Age related macular degeneration, Dyslipidemias, Unspecified visual lossDeregulated Nutrient SensingDyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss.29025108
Hypercholesterolemia, Glucose Intolerance (disease), Hypertriglyceridemia, ObesityDeregulated Nutrient SensingAmong Shors, the following factors increased AH risk: female sex, age, hypercholesterolemia, hyperbetacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), glucose intolerance, and the DD ACE, CT MTHFR, and AA ADRB1 genotypes; among the non-indigenous population, the main factors were age, hypercholesterolemia, hyperbetacholesterinemia, hypoalfacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), and ID ACE genotype.29027816
Diabetes MellitusDeregulated Nutrient SensingDietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients.29027826
Diabetic Nephropathy, Retinal DiseasesDeregulated Nutrient SensingHigher expressions of AGER, DDOST and SIRT1 were observed in Group A. Stratifying by complications, AGER and DDOST expressions were higher in those without retinopathy and without diabetic kidney disease, respectively, compared to patients with these complications.29027826
Glycation End Products, AdvancedDeregulated Nutrient SensingExpression of SIRT1 was higher in patients consuming >=12,872 KU daily of advanced glycation end-products.29027826
Refractory Cytopenia of Childhood, Primary malignant neoplasm, Dyslipidemias, Renal Cell Carcinoma PathwayDeregulated Nutrient SensingRecent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC).29029037
Skeletal muscle structureDeregulated Nutrient SensingReduced skeletal muscle density in older adults is associated with insulin resistance, decreased physical function, and an increased all-cause mortality risk.29030163
Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingPatients with acute ischemic stroke and dyslipidemia randomly received statins within 24 hours after admission in the early group or on the seventh day in the delayed group, in a 1:1 ratio.29030478
Disability, Dyslipidemias, Ischemic strokeDeregulated Nutrient SensingOur randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset.29030478
Steatohepatitis, InflammationDeregulated Nutrient SensingThe outcome variables of interest were indicators of hepatic steatosis, liver enzymes, insulin resistance, inflammation and oxidative stress.29035092
Arterial Stiffness, Dyslipidemias, Hypertension, CTCAE, Cardiovascular DiseasesDeregulated Nutrient SensingThe influence of dyslipidemia might be via moderate arterial stiffness, which results in hypertension and cardiovascular disease.29035100
ETV3 wt AlleleDeregulated Nutrient SensingEarlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance.29037214
Diabetes MellitusDeregulated Nutrient SensingHP genetic variation may have utility as a biomarker of insulin resistance and diabetes risk in Arab-Americans, however, future prospective studies are needed.29039222
Increased insulin level, DyslipidemiasDeregulated Nutrient SensingHe had hyperinsulinemia, dyslipidemia and grade 2 hepatosteatosis.29040067
Prostate Cancer Outcomes Study, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingPCOS is associated with insulin resistance and increased prevalence of prediabetes and Type 2 diabetes (T2D) which is closely linked to obesity and possibly age, ethnicity and PCOS phenotype.29040530
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe rates of hypertension and dyslipidemia were comparable between the two groups.29041913
Refractory anemias, Inflammation, Rheumatoid ArthritisDeregulated Nutrient SensingThe precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive.29041949
ObesityDeregulated Nutrient SensingPinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1.29042127
Hypertension, CTCAE, Endothelial dysfunctionDeregulated Nutrient SensingVascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension.29043342
DyslipidemiasDeregulated Nutrient SensingThe patient was a chronic smoker and had dyslipidemia.29044080
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingDespite this, PCOS subjects experienced steeper increases in cardiovascular risk factors associated with insulin resistance, including triglycerides and HOMA-IR.29044581
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingDiagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion.29045483
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingAutophagy induction enhances tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human bladder cancer cells.29048631
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingMoreover, AICAR, a common AMPK activator, further increased the expression the LC3-II, while AMPK inhibitor compound C partially reversed the LC3-II protein levels in bladder cancer T24 cells.29048631
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingFinally, AICAR significantly reinforced the growth inhibition and apoptosis induction of tetrandrine in T24 and 5637 cells, while compound C had an opposite effect, suggesting that AMPK-mediated autophagy enhanced the cytotoxic and pro-apoptosis effect of tetrandrine in human bladder cancer cells.29048631
Malignant neoplasm of urinary bladder, Primary malignant neoplasmDeregulated Nutrient SensingTaken together, the present study showed that tetrandrine induced autophagy in human bladder cancer cells by regulating the AMPK/mTOR signaling pathway, which contributed to the apoptosis induction by tetrandrine, indicating that tetrandrine may be a potential anticancer candidate for the treatment of bladder cancer, and autophagy may be a possible mechanism for cancer therapy.29048631
AtherosclerosisDeregulated Nutrient SensingOne of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP).29048932
Squamous cell carcinoma, NeoplasmsDeregulated Nutrient SensingSIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma.29050728
Neoplasms, SERPINB3 wt AlleleDeregulated Nutrient SensingSIRT1, has been considered a prominent tumor-suppressing/promoting gene in various solid tumors, although the precise role of SIRT1 in OSCC progression remains unknown.29050728
SERPINB3 wt AlleleDeregulated Nutrient SensingSIRT1 levels in OSCC were determined, SIRT1 overexpression was achieved on transfecting OSCC cells with a SIRT1-containing plasmid, followed by evaluation of proliferative ability and invasiveness of these cells.29050728
SERPINB3 wt AlleleDeregulated Nutrient SensingSIRT1 levels were significantly lower in patients with OSCC than in controls (p < 0.05).29050728
SERPINB3 wt AlleleDeregulated Nutrient SensingMoreover, SIRT1 levels in patients with OSCC were significantly associated with the lymphovascular permeation but not with the sex, age, stage and location.29050728
SERPINB3 wt AlleleDeregulated Nutrient SensingFurthermore, SIRT1 overexpression inhibited proliferation and invasion in OSCC cells.29050728
Neoplasms, SERPINB3 wt AlleleDeregulated Nutrient SensingThe present results suggest that SIRT1 is a potential tumor suppressor in OSCC.29050728
Non-alcoholic Fatty Liver Disease, OsteopeniaDeregulated Nutrient SensingAnalyses using a nationally representative cohort have revealed that high fatty liver index (FLI) is associated with low bone mineral density (BMD) regardless of insulin resistance in men, thereby supporting the deteriorated bone metabolism in nonalcoholic fatty liver disease (NAFLD).29051986
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNAFLD is associated with low bone density regardless of insulin resistance in men.29051986
Alzheimers DiseaseDeregulated Nutrient SensingInsulin signalling deficiencies and insulin resistance have been directly linked to the progression of neurodegenerative disorders like Alzheimer's disease.29053786
TauopathiesDeregulated Nutrient SensingThese results suggest that insulin retention in hyperphosphorylated tau-bearing neurons is a causative factor for the insulin resistance observed in tauopathies, and describe a novel neuropathological concept with important therapeutic implications.29053786
Dyslipidemias, Cardiovascular event, Hypertension, CTCAE, Metabolic Syndrome XDeregulated Nutrient SensingUnivariate logistic regression analysis demonstrated that tobacco consumption (p < .05), serum total 25-hydroxyvitamin D (p < .01), serum endocan levels (p < .01), peak systolic velocity (p < .01), hypertension (p < .001), dyslipidaemia (p < .001), metabolic syndrome (p = .026) and a history of a cardiovascular event (p < .001) significantly increase the risk of severe ED.29057489
Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Malignant Neoplasms, Hypertension, CTCAE, ItalyDeregulated Nutrient SensingThe proportion of patients in Italy and the USA diagnosed with >=1 NCD is estimated to increase from 64% and 71% in 2015 to 89% and 89% by 2035, respectively, driven by moderate cardiovascular disease (CVD) (hypertension and dyslipidaemia), diabetes and malignancies in both countries.29059202
Hyperglycemia, Dyslipidemias, ObesityDeregulated Nutrient SensingImportantly, a novel link between a risk factor profile comprising indices of obesity, hyperglycemia, dyslipidemia and diastolic BP and localized alterations in CT emerged.29062686
DyslipidemiasDeregulated Nutrient SensingThe percentage of females with dyslipidaemia was higher than males (21.2% vs. 14.6%).29063802
DyslipidemiasDeregulated Nutrient SensingHigher adherence to Mediterranean diet was inversely associated with dyslipidaemia (OR: 0.56, 95% Cl: 0.36, 0.86).29063802
Fatty Liver DiseaseDeregulated Nutrient SensingAdherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease: Effect on Insulin Resistance.29063908
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingAmong NAFLD patients, good adherence to Med-Diet was associated with lower insulin resistance.29063908
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, DyslipidemiasDeregulated Nutrient SensingWe included 584 consecutive outpatients presenting with one or more cardiovascular risk factor such as type 2 diabetes mellitus (T2DM), arterial hypertension, overweight/obesity, and dyslipidemia.29063908
ARCN1 gene, ETV3 wt AlleleDeregulated Nutrient SensingFinally, a negative association emerged between smoking and vitamin D. We have estimated, for the first time, the COPD prevalence in MetS and suggest a potential role of smoking in inducing insulin resistance.29065130
ARCN1 geneDeregulated Nutrient SensingMoreover, a direct effect of smoking on vitamin D levels is proposed as a novel mechanism, which may account for both insulin resistance and COPD development.29065130
Diabetes Mellitus, AtherosclerosisDeregulated Nutrient SensingAdipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis.29065866
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Inflammatory disorderDeregulated Nutrient SensingType 2 Diabetes Mellitus (T2DM), which often accompanies dyslipidemia, is considered an inflammatory disease.29066482
DyslipidemiasDeregulated Nutrient SensingAssociation of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China.29066872
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM).29066872
DyslipidemiasDeregulated Nutrient SensingThe genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified.29066872
DyslipidemiasDeregulated Nutrient SensingThese findings suggest that CC genotype of VDR-FokI is a risk factor for T2DM patients with dyslipidemia in elderly males in North China.29066872
Hyperinsulinism, DyslipidemiasDeregulated Nutrient SensingVisceral accumulation of body fat is particularly disadvantageous when it is correlated with insulin resistance, secondary hyperinsulinaemia, dysglicaemia, and atherogenic dyslipidemia.29068599
Arthralgia, Noncommunicable Diseases, Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, Thyroid dysfunction, Morbid obesity, Lung diseases, Hypertension, CTCAEDeregulated Nutrient SensingIncidences of non-communicable diseases (diabetes, hypertension, dyslipidemia, liver disease, lung disease, thyroid dysfunction, and joint pain) were increased in women with morbid obesity.29069258
AHSG protein, human, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome XDeregulated Nutrient SensingFetuin-A is a physiological inhibitor of insulin receptor tyrosine kinase and thus associated with insulin resistance, metabolic syndrome, and an increased risk for type 2 diabetes mellitus (T2DM).29071522
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingInsulin resistance can lead to the pathogenesis of type 2 diabetes and exercise can increase insulin sensitivity.29072034
Parkinson DiseaseDeregulated Nutrient SensingAmnestic dementia impairment in Parkinson's disease: The role of body composition, ageing and insulin resistance.29072169
Presenile dementiaDeregulated Nutrient SensingTo investigate body mass distribution, insulin resistance, and other parameters in patients without dementia, and those with dementia classified as compromised delayed memory.29072169
palladium, Impaired cognitionDeregulated Nutrient SensingThe results of this study indicate an apparent decrease in insulin resistance associated with cognitive impairment in PD.29072169
Fatty Liver, Increased insulin level, ObesityDeregulated Nutrient SensingWhen placed on a 12-week high-fat diet (HFD), Casp2-/- mice resisted the development of obesity, fatty liver, hyperinsulinemia and insulin resistance.29072701
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, NephrolithiasisDeregulated Nutrient SensingNon-alcoholic fatty liver disease (NAFLD), a hepatic manifestation or precursor of metabolic syndrome, may increase nephrolithiasis, a renal manifestation of insulin resistance, but the prospective association between NAFLD and incident nephrolithiasis has not been evaluated.29073130
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingDegree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes.29074329
Hypokalemia, Hyperglycemia, ParalysedDeregulated Nutrient SensingThis transient paralysis is possibly caused by the effects of glucocorticoids on Na-K channels and insulin resistance resulting in hyperglycemia and subsequent hypokalemia.29074369
Postmenopausal stateDeregulated Nutrient SensingGenetic variants in the insulin-like growth factor-I (IGF-I)/insulin resistance axis may interact with lifestyle factors, influencing postmenopausal breast cancer risk, but these interrelated pathways are not fully understood.29074537
Metabolic Syndrome XDeregulated Nutrient SensingBoth C-reactive protein serum concentration and insulin resistance increased in the metabolic syndrome patients.29077157
Dyslipidemias, OverweightDeregulated Nutrient SensingMultivariate logistic regression analyses showed that being overweight was predictive of dyslipidemia (OR 1.76; 95%CI 1.51-2.05, p<0.001) and dyslipidemia awareness (OR 2.58; 95%CI 1.19-5.58; p = 0.017).29077762
Vascular Diseases, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAEDeregulated Nutrient SensingDeterminants (age, sex, hypertension, dyslipidemia, hyperglycemia, obesity, and smoking) of macrovascular diseases affect large-artery endothelial function.29077770
DyslipidemiasDeregulated Nutrient SensingOf 734 patients, 31 (4.2%) received statins for dyslipidemia (statin group) and 703 (95.8%) did not (non-statin group).29081488
Hypertension, CTCAEDeregulated Nutrient SensingIncreased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance.29082259
Diabetes MellitusDeregulated Nutrient SensingMuscular fitness, measured by handgrip strength, is associated with insulin resistance and glucose metabolism in adolescents, which indicates that increasing muscular fitness may have beneficial effects for early prevention of insulin resistance and type 2 diabetes.29082590
Thyroid carcinoma, ThyrotoxicosisDeregulated Nutrient SensingThis study shows for the first time that subclinical thyrotoxicosis in patients with thyroid cancer is associated with insulin resistance, as measured by hyperinsulinemic-euglycemic clamp technique.29083246
Cerebrovascular accidentDeregulated Nutrient SensingPioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke).29084736
Electrocardiogram: myocardial infarction (finding), Cerebrovascular accidentDeregulated Nutrient SensingThe IRIS trial (Insulin Resistance Intervention after Stroke) demonstrated that pioglitazone reduced the risk for a composite outcome of stroke or myocardial infarction among nondiabetic patients with insulin resistance and a recent stroke or transient ischemic attack.29084736
Ischemic strokeDeregulated Nutrient SensingPioglitazone was effective for secondary prevention of ischemic stroke in nondiabetic patients with insulin resistance.29084736
Dyslipidemias, Hyperglycemia, Obesity, Abdominal, Hypertension, CTCAEDeregulated Nutrient SensingThe management of cardiometabolic risk factors, such as abdominal obesity, dyslipidemia, hypertension, and hyperglycemia, is essential for the health of postmenopausal women.29094434
DyslipidemiasDeregulated Nutrient SensingThe main demographic, clinical and vascular risk parameters were comparable between the two groups except for duration of the disease, prevalence of dyslipidemia and use of lipid-lowering drugs (significantly higher in the inducers group) and number of previous antiepileptic drugs (significantly higher in the non-inducers group).29096133
Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Atherosclerosis, Cardiovascular DiseasesDeregulated Nutrient SensingDyslipidemia is a well-known risk factor for atherosclerosis and subsequent cardiovascular disease (CVD).29096835
Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingProspective crossover study for a standardized comparison of the dextrane sulfate whole blood and plasma apheresis system in patients with cardiovascular disease and severe dyslipidemia.29096869
Inflammation, AtherosclerosisDeregulated Nutrient SensingInflammation plays a key role in the development of insulin resistance and atherosclerosis.29098425
Dyslipidemias, Hypertension, CTCAE, Arteriopathic diseaseDeregulated Nutrient SensingHistory of coronary artery disease, dyslipidemia, and hypertension were higher in the older group.29099157
Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Tacca leontopetaloides, Obesity, OverweightDeregulated Nutrient SensingIn private settings, patients had a higher educational level, a major frequency of dyslipidemia, a previous stroke and TIA, less overweight and obesity, a sedentary lifestyle, and diabetes; stroke severity, the rate of systemic complications, the length of stay, and in-hospital mortality were also lower; a major frequency of thrombolysis was observed when compared with public hospitals.29103861
Diabetes Mellitus, Non-Insulin-Dependent, AtherosclerosisDeregulated Nutrient SensingNeighborhood price of healthier food relative to unhealthy food and its association with type 2 diabetes and insulin resistance: The multi-ethnic study of atherosclerosis.29106915
Diabetes MellitusDeregulated Nutrient SensingThis study examined the association between the price of healthier food relative to unhealthy food and type 2 diabetes prevalence, incidence and insulin resistance (IR).29106915
ObesityDeregulated Nutrient SensingTo investigate the associations between irisin and leptin levels in obesity and insulin resistance in a cross sectional study.29108900
Gestational Diabetes, Pregnancy Complications, ObesityDeregulated Nutrient SensingObesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM).29110650
Diabetes MellitusDeregulated Nutrient SensingWe hypothesised that lower HRV is differentially associated with measures of insulin resistance and insulin secretion in recent-onset type 1 and type 2 diabetes.29113812
Diabetes MellitusDeregulated Nutrient SensingInsulin resistance may contribute to the development of early cardiovagal suppression rather than sympathetic predominance in both diabetes types, while in type 1 diabetes a lower glucagon-stimulated insulin secretion is linked to a possibly compensatory higher parasympathetic tone.29113812
CanadaDeregulated Nutrient SensingWhether interventions aimed at reducing insulin resistance could also reduce the risk of CAN remains to be established.29113812
Acanthosis Nigricans, ObesityDeregulated Nutrient SensingLaparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans.29115953
Acanthosis NigricansDeregulated Nutrient SensingThis study is aimed to observe the effect of laparoscopic sleeve gastrectomy (LSG) on body composition and insulin resistance in Chinese obese patients with acanthosis nigricans.29115953
Loss of facial adipose tissueDeregulated Nutrient SensingPatients with AN got noticeable improvement in skin condition and their AN score was significantly decreased (3.52 +- 0.79 vs. 1.48 +- 0.73, P < 0.001).Alleviated insulin resistance and more trunk fat loss than limbs' were observed in both groups (P value < 0.01).29115953
Glucose Intolerance (disease), Unclassified Hepatocellular AdenomaDeregulated Nutrient SensingUnclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance.29116626
SarcopeniaDeregulated Nutrient SensingSarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency.29120677
Sarcopenia, ObesityDeregulated Nutrient SensingThere was also a significant association between sarcopenia and insulin resistance, independent of vitamin D and obesity status (p < 0.0001).29120677
SarcopeniaDeregulated Nutrient SensingIn the subgroup analysis, insulin resistance was found to be determined by sarcopenic rather than vitamin D status.29120677
Sarcopenia, ObesityDeregulated Nutrient SensingSarcopenia was associated with both insulin resistance and 25-hydroxyvitamin D concentration in postmenopausal Korean women, regardless of obesity status.29120677
SarcopeniaDeregulated Nutrient SensingSarcopenia is therefore of greater clinical importance due to its close relationship with insulin resistance.29120677
Dyslipidemias, diabeticDeregulated Nutrient SensingDyslipidaemia in a Black African diabetic population: burden, pattern and predictors.29121994
Dyslipidemias, diabeticDeregulated Nutrient SensingThis study sought to assess the burden, pattern and predictors of dyslipidaemia in 425 adult diabetic patients in Uganda.29121994
Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes MellitusDeregulated Nutrient SensingCollectively, the predictors of dyslipidaemia were: female gender, study site (private hospitals), type of diabetes (type 2 diabetes mellitus), statin therapy, increased body mass index and diastolic blood pressure.29121994
Dyslipidemias, diabeticDeregulated Nutrient SensingProactive screening of dyslipidaemia and its optimal management using lipid lowering therapy should be emphasised among adult diabetic patients in Uganda.29121994
DyslipidemiasDeregulated Nutrient SensingThe association between AVNFH and dyslipidaemia remains controversial.29126401
Femoral Neck Fractures, DyslipidemiasDeregulated Nutrient SensingOur purpose herein was to evaluate the association between dyslipidaemia and AVNFH following low-energy femoral neck fractures treated with cancellous screws in elderly patients in our tertiary care centre.29126401
Hypertension, CTCAE, Dyslipidemias, Cardiovascular DiseasesDeregulated Nutrient SensingCardiovascular diseases are mainly related to hypertension and dyslipidemia and increase with aging because of the larger time span for these risk factors to damage arterial blood vessels.29128438
Weight GainDeregulated Nutrient SensingFurther studies to investigate the effect of sleep curtailment on weight gain through stress and insulin resistance are necessary.29129611
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingAt least three cardiovascular risk factors were found in 46% of patients, with the most common dyslipidaemia (77.4%) and abdominal obesity (74.8%).29131289
Dyslipidemias, Overweight, ObesityDeregulated Nutrient SensingNo significant difference was found in overweight, obesity, or dyslipidemia.29132553
Infarction, Demographics DomainDeregulated Nutrient SensingHowever, few studies have focused on the prognostic value of glycosylated hemoglobin (HbA1c) and Homeostatic Model Assessment 2 for Insulin Resistance (HOMA2-IR) in patients with DM, non-ST-segment elevation infarction (NSTEMI), and single concomitant chronic total occlusion (CTO) following primary percutaneous coronary intervention (PCI).29137017
DyslipidemiasDeregulated Nutrient SensingWith the increase of serum 25(OH) D3 levels, the incidence of dyslipidemia decreased.29137635
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPatients with SMI had higher rates of diabetes, hypertension, and dyslipidemia.29138173
Dyslipidemias, Cardiovascular Diseases, Diabetes MellitusDeregulated Nutrient SensingThe proportion of visits by HIV-infected versus HIV-uninfected adults with aspirin/antiplatelet therapy when patients met guideline-recommended criteria for primary prevention or had cardiovascular disease was 5.1% versus 13.8% (P=0.03); the proportion of visits with statin therapy when patients had diabetes mellitus, cardiovascular disease, or dyslipidemia was 23.6% versus 35.8% (P<0.01).29138182
ARCN1 geneDeregulated Nutrient SensingSIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients.29138552
ARCN1 gene, InflammationDeregulated Nutrient SensingLongevity gene, SIRT1, is reported to be involved in the pathogenesis of COPD by regulating the signaling pathways of oxidative stress, inflammation, and aging.29138552
ARCN1 geneDeregulated Nutrient SensingWe hypothesize that SIRT1 and related genes are also associated with the benefits of PA in COPD patients.29138552
Obesity, Abdominal, DyslipidemiasDeregulated Nutrient SensingWe performed an 18-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch.29142011
Somatotropin deficiencyDeregulated Nutrient SensingGrowth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance.29143180
Hypercholesterolemia, Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe first is to estimate the prevalence of dyslipidaemia (hypercholesterolaemia, hypertriglyceridaemia, high low-density lipoprotein (LDL) level and low high-density lipoprotein (HDL) level), as well as the mean levels of total cholesterol, triglyceride, LDL and HDL, in the urban and rural Yangon Region, Myanmar.29146640
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingKnockdown of SIRT1 Suppresses Bladder Cancer Cell Proliferation and Migration and Induces Cell Cycle Arrest and Antioxidant Response through FOXO3a-Mediated Pathways.29147649
Metabolic Diseases, NeoplasmsDeregulated Nutrient SensingSIRT1 is a key member of Sirtuins, playing important roles in aging and energy metabolism, which has been reported to be involved in various metabolic diseases and tumors.29147649
Dyslipidemias, Prediabetes syndrome, Hypertension, CTCAE, Osage languageDeregulated Nutrient SensingThirty-two percent of mild OSA patients had MS, 43.5% of mild OSA patients had hypertension, 14% showed dyslipidemia, and 56% had prediabetes.29148894
PancreatitisDeregulated Nutrient SensingAlthough the IFALD improved, he had signs of insulin resistance and struggled with numerous episodes of pancreatitis.29148930
ObesityDeregulated Nutrient SensingReduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance.29150224
ObesityDeregulated Nutrient SensingSIRT1 and SIRT2 expression and AMPK levels decrease in children with obesity and IR.29150224
Lipolysis, Adipocyte hypertrophy, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis.29153750
Adipocyte hypertrophy, Diabetes MellitusDeregulated Nutrient SensingAlso, 24% of probands had a family history of diabetes, which was associated with higher body mass index (BMI) scores, and more insulin resistance (HOMAIR) and adipose hypertrophy.29153750
Steatohepatitis, FETUB gene, Diabetes MellitusDeregulated Nutrient SensingFetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis.29153939
Weight decreasedDeregulated Nutrient SensingRole of rs1501299 variant in the adiponectin gene on total adiponectin levels, insulin resistance and weight loss after a Mediterranean hypocaloric diet.29154912
Sleep-Disordered Breathing, Dyslipidemias, Hypertension, CTCAE, GDC Comorbidity TerminologyDeregulated Nutrient SensingDyslipidemia, sleep-disordered breathing (SDB) and hypertension are comorbid factors evidenced in adults, but poorly studied in old people.29157582
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe prevalence of high-risk dyslipidemia decreased from 61.3 to 44.4%, and hypertension from 57.9 to 27.4%.29157582
Diabetes MellitusDeregulated Nutrient SensingEffects of hepato-preferential basal insulin peglispro on nuclear magnetic resonance biomarkers lipoprotein insulin resistance index and GlycA in patients with diabetes.29160108
Increased insulin level, Metabolic DiseasesDeregulated Nutrient SensingWe conclude that in obese, older and sedentary men, acute exercise modifies skeletal muscle mitochondrial respiration and H2O2 emission responses to hyperinsulinemia in a respiratory state-specific manner, which may have implications for metabolic diseases involving insulin resistance.29161316
Hypertensive diseaseDeregulated Nutrient SensingFurthermore, rs13175330 G allele carriers in the HTN w/o therapy group had significantly increased levels of insulin, insulin resistance, and oxidized low-density lipoprotein (LDL) and significantly decreased LDL-cholesterol levels and LDL particle sizes compared to the AA carriers.29162152
Hypertensive diseaseDeregulated Nutrient SensingAdditionally, the PAM rs13175330 G allele might be associated with insulin resistance and LDL atherogenicity in patients with HTN.29162152
Cerebral Small Vessel Diseases, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia predicts higher risk of coronary events and stroke and might be associated with cerebral small vessel disease (SVD).29162363
Inflammation, ObesityDeregulated Nutrient SensingLow grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity.29166392
Glucose Intolerance (disease), Ralstonia pickettii, ObesityDeregulated Nutrient SensingIntestinal Ralstonia pickettii augments glucose intolerance in obesity.29166392
Dyslipidemias, Obesity, Diabetes MellitusDeregulated Nutrient SensingStatin users had a high prevalence of obesity and diabetes, as well as dyslipidemia.29167018
Colorectal CarcinomaDeregulated Nutrient SensingMetformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production.29167573
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most transferable processes concerned health maintenance (32.1%) and cardiovascular risk factors (hypertension (28.7%), dyslipidaemia (25.3%) and diabetes (24.3%)).29170284
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingMicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling.29174979
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingUbiquitin-specific peptidase 22 (USP22) is upregulated in NSCLC and promotes tumorigenesis via a Sirt1-JAK-STAT3 pathway.29174979
Non-Small Cell Lung CarcinomaDeregulated Nutrient SensingTaken together, these findings suggest that miR-30e-5p suppresses NSCLC tumorigenesis by downregulatingUSP22-mediated Sirt1/JAK/STAT3 signaling.29174979
Malignant neoplasm of urinary bladderDeregulated Nutrient SensingTM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARg-SIRT1 feedback loop in human bladder cancer cells.29175458
Hepatotoxicity, DyslipidemiasDeregulated Nutrient SensingAlthough clinical investigation of LY2584702 has been terminated because of hepatotoxicity risk, we suggest that a selective inhibitor of p70 S6 serine/threonine protein kinase-1 with a larger margin of safety and without the possibility of being metabolized to 4-APP may be useful in the treatment of dyslipidemia.29178617
Inflammation, Obesity, Diabetes MellitusDeregulated Nutrient SensingObesity-induced inflammation engenders insulin resistance and type 2 diabetes mellitus (T2DM) but the inflammatory effectors linking obesity to insulin resistance are incompletely understood.29180649
ObesityDeregulated Nutrient SensingHepatic PTPR-g overexpression that mimics levels found in obesity is sufficient to cause severe hepatic and systemic insulin resistance.29180649
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingIndividuals who were overweight/obesity, with dyslipidemia, or diabetes were at a higher risk of hypertension; these people also more likely to be aware of their condition.29180804
Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingMoreover, dyslipidemia (OR = 0.600; 95% CI: 0.375, 0.960) were associated with poor hypertension control.29180804
Hyperglycemia, Dental PlaqueDeregulated Nutrient SensingFasting plasma glucose, 2 h postprandial glucose and Homeostasis model assessment of insulin resistance, triglycerides, plaque were significantly higher in the hyperglycemia group than non-hyperglycemia.29183105
DysglycemiaDeregulated Nutrient SensingIn adolescents with dysglycemia, there was marked insulin resistance (insulin sensitivity index: adolescents, median [interquartile range] 1.8 [1.1-2.4] x 10-4; adults, 5.0 [2.3-9.9]; P = 0.01).29183909
hearing impairment, Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingDyslipidemia as a Potential Moderator of the Association between Hearing Loss and Depressive Symptoms.29188892
hearing impairment, Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingWe investigated dyslipidemia as a potential moderator of the association between hearing/hearing loss and depressive symptoms.29188892
hearing impairment, Dyslipidemias, Bipolar DisorderDeregulated Nutrient SensingThe findings provide some support for moderation of the association between hearing/hearing loss and depressive symptoms by dyslipidemia, with important lipid-specific and hearing measure-specific differences.29188892
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingThe most common comorbidities were hypertension (82.0%) and dyslipidaemia (76.6%).29188902
Inflammation, Bipolar DisorderDeregulated Nutrient SensingThe association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women.29190710
Inflammation, Depression, CTCAEDeregulated Nutrient SensingDepression has been shown to be associated with elevated leptin levels, low-grade inflammation and insulin resistance.29190710
Hypertension, CTCAE, Albuminuria, Dyslipidemias, ObesityDeregulated Nutrient SensingSo we determined the adequacy of control of the modifiable risk factors: glycaemic control, hypertension, dyslipidemia, obesity and albuminuria in the study patients from rural and peri-urban dwelling.29191193
Albuminuria, Cardiovascular morbidity, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is associated with substantial cardiovascular morbidity and mortality arising from the high prevalence of cardiovascular risk factors such as hypertension, dyslipidaemia, obesity, poor glycaemic control and albuminuria.29191193
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingPatients with older age, hypertension and dyslipidemia as well as those who smoked were at higher risk of developing LEAD.29191431
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingEmpagliflozin decreases remnant-like particle cholesterol in type 2 diabetes patients with insulin resistance.29193767
Diabetes MellitusDeregulated Nutrient SensingEMPA decreases RLP-C levels, which is closely associated with amelioration of insulin sensitivity in diabetes patients who have insulin resistance.29193767
Carotid Atherosclerosis, Dyslipidemias, ObesityDeregulated Nutrient SensingBesides traditional risk factors, such as dyslipidemia, smoking, obesity, and carotid atherosclerosis, novel factors are under investigation such as genetic polymorphisms.29196930
Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMalaysian/Bruneian patients had lower rates of myocardial infarction (54.55% versus 59.76%, p=0.033) and higher rates of diabetes (43.24% versus 28.99%, p<0.001) and dyslipidaemia (90.42% versus 74.66%, p<0.001) compared with the RoW.29197883
Dyslipidemias, Malignant Neoplasms, ObesityDeregulated Nutrient SensingObesity, which is commonly accompanied by dyslipidemia, is associated with an increased risk of certain cancers.29197994
Dyslipidemias, ObesityDeregulated Nutrient SensingOmentin-1 might play a role on insulin resistance, dyslipidemia and obesity.29198435
Dyslipidemias, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular DiseasesDeregulated Nutrient SensingThe morbidity of cardiovascular disease in patients with type 2 diabetes mellitus (DM) deteriorates in combination with dyslipidemia.29199201
Hyperglycemia, DyslipidemiasDeregulated Nutrient SensingThe current study investigated whether the dipeptidyl peptidase-4 inhibitor sitagliptin ameliorates dyslipidemia and hyperglycemia.29199201
Endothelial dysfunctionDeregulated Nutrient SensingIn all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction.29200598
Refractory anemias, InflammationDeregulated Nutrient SensingThe group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p < 0.00001).29200598
Refractory anemias, Endothelial dysfunctionDeregulated Nutrient SensingIn early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction.29200598
Diabetes MellitusDeregulated Nutrient SensingAndrogen receptor CAG repeat polymorphism is not associated with insulin resistance and diabetes among South Asian males.29202793
Prostate Cancer Outcomes Study, Glucose Intolerance (disease), Diabetes MellitusDeregulated Nutrient SensingThese data suggest that routine screening for diabetes in prevention strategies does not need to be emphasized for PCOS patients at late reproductive ages if they have not been affected by glucose intolerance up to that point.29202960
Atherosclerosis, Coronary heart diseaseDeregulated Nutrient SensingEffect of pioglitazone on insulin resistance, progression of atherosclerosis and clinical course of coronary heart disease.29203734
Atherosclerosis, Coronary heart disease, Choline Dehydrogenase, MitochondrialDeregulated Nutrient SensingOur aim was to study the effect of pioglitazone on insulin resistance, the clinical course of atherosclerosis and coronary heart disease (CHD).29203734
Atherosclerosis, Coronary heart diseaseDeregulated Nutrient SensingLong-term treatment with pioglitazone at low doses against the background of standard therapy contributes to functional and clinical condition of patients, promotes the prevention of atherosclerosis and reduction of insulin resistance, thereby improving the clinical manifestations of coronary heart disease.29203734
Adult GlioblastomaDeregulated Nutrient SensingFOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain.29207098
Glioblastoma Multiforme PathwayDeregulated Nutrient SensingPreclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma.29207163
Dyslipidemias, Hypertension, CTCAE, Diabetes MellitusDeregulated Nutrient SensingThese cutoff levels for NC were associated with a significantly increased risk for diabetes, dyslipidemia, and hypertension.29209671
Dyslipidemias, Dysglycemia, ObesityDeregulated Nutrient SensingThose attending a screening visit with any 3 or more risk factors of central obesity, dyslipidemia (high triglycerides or low high density lipoprotein cholesterol) elevated blood pressure and dysglycemia were randomized to either nurse-led health and lifestyle modification (intervention) or standard care (control).29212477
ObesityDeregulated Nutrient SensingWHtR showed stronger associations with measures of insulin resistance and truncal obesity than WHR.29214673
Transient Ischemic AttackDeregulated Nutrient SensingApolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response.29215310
Stomach CarcinomaDeregulated Nutrient SensingGastric cancer surgery led to decreased ghrelin and leptin and increased PYY and GIP, which might have a role in improving insulin resistance and glucose homeostasis.29216250
DyslipidemiasDeregulated Nutrient SensingThe combination of GLP-1RAs and statins may be a reasonable therapeutic option in T2DM with dyslipidemia.29217412
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPreventing dyslipidaemia and diabetes in South Asians may therefore help reduce their excess risk of CVD.29217719
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe problem of dyslipidemia is high in patients with diabetes mellitus.29217920
Dyslipidemias, Demographics Domain, Atherosclerosis, Coronary heart diseaseDeregulated Nutrient SensingThus, DM patients are more prone to dyslipidemia which is an important risk factor for atherosclerosis and coronary heart disease.29217920
Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough white blood cell and C-reactive protein are associated with adiposity and insulin resistance, these inflammatory markers also independently predict type 2 diabetes and/or hypertension.29221802
Adrenal Cortex HormonesDeregulated Nutrient SensingIn U937 cells, treatment with quercetin activated AMPK and induced expression of nuclear factor erythroid 2-related factor 2, and consequently reversed CSE-induced corticosteroid insensitivity.29227717
Hyperglycemia, Dyslipidemias, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingHyperglycaemia co-morbidity with dyslipidaemia (5.0%), obesity (3.1%) and hypertension (1.8%) were observed.29228975
Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingDyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors.29229232
Dyslipidemias, Ischemic stroke, Cerebrovascular accidentDeregulated Nutrient SensingWe performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values.29229232
Hypertriglyceridemia, Dyslipidemias, Cerebrovascular accidentDeregulated Nutrient SensingWe analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia.29229232
Dyslipidemias, OverweightDeregulated Nutrient SensingDyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight.29229232
Hypertriglyceridemia, Ischemic stroke, DyslipidemiasDeregulated Nutrient SensingDyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children.29229232
Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingMorbidly obese patients had a higher rate of hypertension, dyslipidemia, and diabetes mellitus compared with normal or overweight patients.29232296
Lipodystrophy, hormone-sensitive lipase activityDeregulated Nutrient SensingMechanistic study revealed that deficiency of HSL in adipose tissue caused inflammatory macrophage infiltrates, progressive lipodystrophy, abnormal adipokine secretion and systemic insulin resistance.29232702
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThey often had associated comorbidities (coinfection HCV/HVB 40.5%, smoking 45.8%; hypertension 33.4%, dyslipidemia 28.8%, diabetes 14.8%).29233572
Diabetes MellitusDeregulated Nutrient SensingOur data suggest that age and apparent 11b-HSD2 activity modulate the association of copeptin with insulin resistance at the population level but not MeTS or diabetes.29235050
Increased insulin level, insulinoma, NeoplasmsDeregulated Nutrient SensingWe also show that in response to chronic hyperinsulinemia, patients with insulinoma develop protective mechanisms responsible for a marked insulin resistance, which is reversible after complete resection of the tumour.29241949
Acute Coronary Syndrome, DyslipidemiasDeregulated Nutrient SensingCompared with younger patients, octogenarians smoked and had dyslipidemia less often, and presented more frequently with acute coronary syndrome.29243834
DyslipidemiasDeregulated Nutrient SensingDyslipidemia may influence strongly before puberty and in late adolescence when plasma levels are naturally highest.29245288
TG gene, DyslipidemiasDeregulated Nutrient SensingIsolated high TG (normal LDL + normal HDL+ high TG) was most common type of combined dyslipidemia for female elderly (22.2%), female nonelderly (23.2%) and male elderly (24.1%) patients.29246160
DyslipidemiasDeregulated Nutrient SensingDyslipidemia is more prevalent in the non-elderly than in the elderly for males.29246160
Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Cerebrovascular accident, Chronic lung disease, Arthritis, Hypertension, CTCAEDeregulated Nutrient SensingSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis.29247088
Deficit, Cessation of life, Kidney Failure, Congestive heart failureDeregulated Nutrient SensingMultivariable analyses identified base deficit, intubation, congestive heart failure, dyslipidemia/statin use, and renal failure as predictors of operative death.29249502
myocardial injuryDeregulated Nutrient SensingPerioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of AMPK.29250545
Dyslipidemias, UlcerDeregulated Nutrient SensingDyslipidemia (p=0.04), ESD procedure time (p=0.003) and artificial ulcer size (p<0.001) were identified as risk factors for delayed healing, with location in the lower third of the stomach [Odds ratio (OR) 6.76; p=0.016] and artificial ulcer size (OR, 1.18; p=0.024) retained as independent risk factors.29253050
DyslipidemiasDeregulated Nutrient SensingPioglitazone attenuates cardiometabolic risk factors in non-diabetic patients with dyslipidemia.29256535
DyslipidemiasDeregulated Nutrient SensingTo determine the effect of pioglitazone on cardiometabolic risk factors in non-diabetic patients with dyslipidaemia.29256535
DyslipidemiasDeregulated Nutrient SensingThis prospective, randomised clinical trial was conducted at Sheikh Zayed Medical College and Hospital, Rahim Yar Khan, Pakistan, from August to October 2016, and comprised non-diabetic patients with dyslipidaemia.29256535
Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt Allele, AtherosclerosisDeregulated Nutrient SensingYet, the clinical criteria for MetS are insensitive to the early-stage insulin resistance, inflammation, cholesterol and clotting factor abnormalities that characterize the progression toward type 2 diabetes and atherosclerosis.29258604
Increased insulin level, Dyslipidemias, InflammationDeregulated Nutrient SensingAfter correcting for confounders, low water T2 values were independently and additively associated with fasting hyperinsulinemia, dyslipidemia and subclinical inflammation.29258604
Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingWe detected high-order interactions between dyslipidemia, GRS, smoking status, age and diabetes.29258680
Hyperlipidemia, DyslipidemiasDeregulated Nutrient SensingEvaluation of dyslipidaemia and the impact of hypolipidemic therapy on prognosis in high and very high risk patients through the Hyperlipidaemia Therapy in tERtiary Cardiological cEnTer (TERCET) Registry.29258913
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingGlycA was higher among older, women, smokers, alcohol abstemious, obese and in those with diabetes, hypertension or dyslipidemia.29262791
Hypertension, CTCAE, Cardiovascular Diseases, HandDeregulated Nutrient SensingAs adults age with HIV, they are more likely to develop comorbidities such as cardiovascular disease, hypertension, and insulin resistance that may further contribute to poorer cognitive functioning and HAND.29266286
Hypertension, CTCAE, Dyslipidemias, GoutDeregulated Nutrient SensingCo-morbidities were common, particularly hypertension (49.7%), dyslipidaemia (40.1%) and gout (15.9%).29268719
Increased insulin level, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingType 2 diabetes is characterized by insulin resistance, hyperinsulinemia and hepatic overproduction of glucose and lipids.29269047
Prostate Cancer Outcomes StudyDeregulated Nutrient SensingVitamin D deficiency may contribute to the development of insulin resistance, visceral fat and low level of adiponectin which are common feature in PCOS women.29271278
Chronic Kidney DiseasesDeregulated Nutrient SensingRecently, we demonstrated that plasma aldosterone contributed to insulin resistance in chronic kidney disease.29271574
Cardiovascular systemDeregulated Nutrient SensingIn conclusion, in hemodialysis patients, aldosterone levels and insulin resistance are closely interrelated and the constellation of the two is related to severe cardiovascular tissue damages.29271574
Dyslipidemias, BergamotDeregulated Nutrient SensingEffects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial.29273027
Dyslipidemias, Bergamot, ObesityDeregulated Nutrient SensingRecent experiments suggest that Citrus bergamia extracts could benefit people with dyslipidemia and obesity but this needs to be further validated.29273027
DyslipidemiasDeregulated Nutrient Sensing12-week supplementation of CitriCholess could benefit lipid metabolism and weight management in old adults with dyslipidemia.29273027
TG gene, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingLoss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas.29273469
Obesity, Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingPredominantly male (80%, mean age 65.5years), cardiovascular risk factors were common (hypertension 65%, dyslipidemia 65%, obesity 25%, diabetes mellitus 28.5%, and smokers 67%).29276176
Tumor necrosisDeregulated Nutrient SensingTogether, these findings suggest that BMI is associated with blood DNA methylation at a large number of CpGs across the genome, several of which are located in or near genes involved in ATP-binding cassette transportation, tumour necrosis factor signalling, insulin resistance and lipid metabolism.29278407
Weight Gain, Hyperbilirubinemia, DyslipidemiasDeregulated Nutrient SensingOur results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.29279144
Thyroid dysfunction, Dyslipidemias, Retinal Diseases, Diabetes MellitusDeregulated Nutrient SensingThyroid dysfunction was more prevalent in females, with presence of dyslipidemia, retinopathy, poor glycemic state (HbA1c >=7) and longer duration of diabetes as significant contributing factors associated.29279270
Communicable DiseasesDeregulated Nutrient SensingSirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain.29280055
ObesityDeregulated Nutrient SensingHowever, in humans, the role of resistin in obesity and insulin resistance has not yet been demonstrated.29280648
ObesityDeregulated Nutrient SensingOur results do not support a relationship among resistin levels, obesity and insulin resistance in humans.29280648
Hypertension, CTCAE, Dyslipidemias, PrehypertensionDeregulated Nutrient SensingDependent variables: hypertension, pre-hypertension, overweight/obesity, impaired glucose, insulin resistance and dyslipidemia.29280649
Hypertriglyceridemia, DyslipidemiasDeregulated Nutrient SensingThe lowest rate of dyslipidemia (hypertriglyceridemia or low high-density lipoprotein cholesterol) was observed in acute bipolar mania.29280686
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most common self-reported NCD was hypertension (17.%), followed by diabetes (16.3%) and dyslipidaemia (15.6%).29284464
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingThe most prevalent risk factors were hypertension (78.8%), dyslipidemia (36.3%), and diabetes (31.9%).29284569
Impaired cognitionDeregulated Nutrient SensingThe findings in this present study highlight that hispidulin offers neuroprotection against sevoflurane-induced cognitive dysfunction, which is mediated by autophagy induction through activating AMPK signaling.29287193
Pain Distress Question, Dyslipidemias, Hypertension, CTCAEDeregulated Nutrient SensingThe most common comorbidities were dyslipidaemia (40.3%), hypertension (40.1%) and generalised pain (38.1%).29287992
Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingAlthough increase in insulin resistance and decrease in beta-cell function both contributed to the progression to type 2 diabetes from prediabetes, longitudinal change in insulin resistance was the predominant factor in Koreans.29289263
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingAbout 70% of patients reported comorbid hypertension or dyslipidemia.29289467
Metabolic DiseasesDeregulated Nutrient SensingPostoperative insulin resistance represents a major component of postoperative metabolic disorder.29306619
Chronic Kidney DiseasesDeregulated Nutrient SensingVitamin D receptor activation by paricalcitol and insulin resistance in CKD.29307660
Chronic Kidney DiseasesDeregulated Nutrient SensingThe nature of the link (causal vs non-causal) between low 1,25-OH vitamin D and insulin resistance (IR) in patients with chronic kidney disease (CKD) remains elusive.29307660
Endothelial dysfunctionDeregulated Nutrient SensingThey had higher insulin resistance and endothelial dysfunction.29313572
Dyslipidemias, Coronary Artery Disease, Obesity, Diabetes MellitusDeregulated Nutrient SensingMale patients were younger (69+-11years vs. 75+-12years in females; p<0.001) but had higher obesity (8.0% vs 6.5%), dyslipidemia (33.2% vs 28.1%), smoking (12.9% vs 9.2%), coronary artery disease (29.4% vs 19.5%), or diabetes rates (35.8% vs 28.1%; each p<0.001).29329771
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPattern Of Dyslipidaemia And Its Association With Hypovitaminosis D In Type 2 Diabetes Mellitus.29330987
DyslipidemiasDeregulated Nutrient SensingThe purpose of our study was to determine the pattern of dyslipidaemia and its association with low vitamin D levels in South Asian diabetics.29330987
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingWe found that dyslipidaemia is highly prevalent in patients with type 2 diabetes mellitus in Pakistan.29330987
Hyperglycemia, Dyslipidemias, Complications of Diabetes MellitusDeregulated Nutrient SensingIn order to decrease the development of diabetic complications aggressive management of hyperglycaemia and dyslipidaemia is required.29330987
Weight decreasedDeregulated Nutrient SensingOur data show that the rs10767664 variant of the BDNF gene modifies insulin resistance and insulin levels after weight loss with a hypocaloric diet enriched with MUFAs.29339649
Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, ObesityDeregulated Nutrient SensingAge, gender, living area, employment status, obesity, hypertension, and dyslipidemia are the contributing factors to diabetes mellitus.29348378
Non-alcoholic Fatty Liver Disease, ObesityDeregulated Nutrient SensingOne of the adipokines is resistin, the role of which in insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD) needs to be determined.29363914
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingResistin probably plays a role in the pathogenesis of hepatic insulin resistance and aggravates pathologic changes in the liver of patients with NAFLD.29363914
Dyslipidemias, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingResistin expression was more intense in patients with type 2 diabetes mellitus and dyslipidaemia and less intense in the control group.29363914
ObesityDeregulated Nutrient SensingPredictors of Insulin Resistance in Children versus Adolescents with Obesity.29375912
Metabolic DiseasesDeregulated Nutrient SensingThis study indicates that cadmium burden alters glycemic control in adolescents and suggests that oxidative stress plays a key role in cadmium-induced insulin resistance, increasing the risk of developing metabolic disorders.29379585
Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAEDeregulated Nutrient SensingLSG improved dyslipidemia in 67.8% of patients, a significant remission of hepatic steatosis 47% and 37.7% systemic arterial hypertension; type 2 diabetes remission was complete.29412386
Carcinogenic Chlorinated Hydrocarbon, Hepatitis CDeregulated Nutrient SensingThis study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data.29412389
Dyslipidemias, Kidney DiseasesDeregulated Nutrient SensingThe association between the increase in pulse pressure and renal function in chronic kidney disease patients with dyslipidemia.29441846
Dyslipidemias, Chronic Kidney DiseasesDeregulated Nutrient SensingTherefore, we examined the association of increased PP on renal function in patients with CKD and dyslipidemia.29441846
Dyslipidemias, Hypertension, CTCAE, Musculoskeletal Diseases, Diabetes MellitusDeregulated Nutrient SensingHypertension (48.6%), dyslipidaemia (33.1%), musculoskeletal disorders (21.0%) and diabetes mellitus (16.1%) were the most frequent comorbidities.29441984
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingThe Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes.29445750
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingTo investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes.29445750
Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingMonocyte surface CD163 expression levels were more significantly associated with insulin resistance than sCD163 in patients with type 2 diabetes, suggesting a novel pathophysiological role of CD163.29445750
Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingRisk factors were 60 (75.9%), smoking, 47 (59.5%) hypertension, 25 (31.6%) diabetes, 22 (27.8%) dyslipidaemia and 16 (20.3%) heart failure.29453473
Dyslipidemias, ObesityDeregulated Nutrient SensingFurther, by multiple logistic regression analysis we found that only dyslipidemia (p = 0,001), obesity (p = 0,007), testosterone < 300 ng/dl (p < 0,0001) and ED (p < 0,0001) were independent predictors of future events.29473384
Narcolepsy, Glucose Intolerance (disease), Headache, Traumatic injury, Peripheral NeuropathyDeregulated Nutrient SensingAt the end of the prolonged observation period of 9.9 years (SD 7.27 years), there was increased association of narcolepsy with peripheral neuropathy (11.21, 1.16-108.11), non-migrainous headache (6.00, 1.73-20.83), glucose intolerance (2.39, 1.05-5.45), and automobile-related trauma (2.43, 1.08-5.45).29482805
Vascular Diseases, Dyslipidemias, Decline in functional status, ETV3 wt AlleleDeregulated Nutrient SensingRisk factors including MetS, old age, sex, wide pulse pressure, increased hemoglobin A1c, dyslipidemia and decline renal function were associated with micro- and macrovascular disease.29661347
Hypertension, CTCAE, DyslipidemiasDeregulated Nutrient SensingHypertension, dyslipidemia, and smoking, in this order of magnitude, were the most prevalent risk factors.29701366
ARCN1 gene, Dyslipidemias, Renal Insufficiency, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Aortic valve disorderDeregulated Nutrient SensingThe preoperative comorbidities were hypertension (83.9%), aortic valve disease (54.8%), dyslipidaemia (48.4%), renal impairment (9.7%), type 2 diabetes mellitus (9.7%) and COPD (3.2%).29701390
Peripheral Vascular Diseases, CAV1 gene, DyslipidemiasDeregulated Nutrient SensingAlthough not reaching statistical significance, CAV patients also had more dyslipidemia (60% vs. 50%), history of smoking (52% vs. 44%) and peripheral vascular disease (45% vs. 29%).29701389
ARCN1 gene, Dyslipidemias, Renal Insufficiency, Hypertension, CTCAE, Aortic valve disorderDeregulated Nutrient SensingThe preoperative comorbidities were hypertension (64.5%), dyslipidaemia (45.2%), aortic valve disease (35.4%), renal impairment (9.7%) and COPD (3.2%).29701394
DyslipidemiasDeregulated Nutrient SensingThey also had low incidence of coronary risk factors (especially dyslipidemia, p=0.04).29716697
Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, ObesityDeregulated Nutrient SensingMetabolic risk factors associated with non-alcoholic fatty liver disease (NAFLD) include Type 2 diabetes mellitus (T2DM), obesity and dyslipidaemia.29778128
Hypertension, CTCAE, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingCardio-vascular risk factors (%): hypertension (60), Mellitus diabetes (47), dyslipidemia (29) and smoking (26).29878290
Non-alcoholic Fatty Liver Disease, DyslipidemiasDeregulated Nutrient SensingStudies suggest that the main pathophysiologic and pathogenetic processes of formation of NAFLD (insulin resistance and dyslipidemia) significantly more pronounced in younger patients.29889391
Demographics Domain, Diabetes Mellitus, Non-Insulin-DependentDeregulated Nutrient SensingPioglitazone is an extremely useful agent in the treatment of type 2 diabetes mellitus (DM) through its actions on alleviating insulin resistance.29900709
Non-alcoholic Fatty Liver Disease, Prediabetes syndromeDeregulated Nutrient SensingElevated levels of serum uric acid and insulin resistance are associated with nonalcoholic fatty liver disease among prediabetic subjects.30234279
Non-alcoholic Fatty Liver DiseaseDeregulated Nutrient SensingNonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of insulin resistance and serum uric acid (SUA) levels seemed to be elevated during this disorder.30234279
Non-alcoholic Fatty Liver Disease, Prediabetes syndromeDeregulated Nutrient SensingIncreased levels of serum uric acid are significantly associated with NAFLD and this association seemed to be mediated by insulin resistance among prediabetic subjects.30234279
Obesity, Abdominal, Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Diabetes MellitusDeregulated Nutrient SensingLength of service can determine cases numbers of cardiovascular disorders, diabetes mellitus manifestations, more frequent combination of hyperglycemia and/or hyper-, dyslipidemia with abdominal obesity.30351723
Diastolic dysfunction, DyslipidemiasDeregulated Nutrient SensingThere was no significant association between diastolic dysfunction and dyslipidaemia, BMI, tobacco smoking, alcohol consumption, HbA1c and gender.30353895