| Increased insulin level, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia are often found in first-degree relatives of non-insulin-dependent diabetes mellitus (NIDDM) patients, and are currently considered a familial trait of this population at increased risk for diabetes. | 7476284 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In this population, the current view of insulin resistance in "early" diabetes was supported by insulin-specific measurements. | 7476300 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Aging is associated with an increased accumulation of abdominal fat, glucose intolerance, and insulin resistance. | 7476341 |
| Polycystic Ovary Syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | Hormonally regulated serine phosphorylation of human P450c17 suggests a possible mechanism for human adrenarche and may be a unifying etiologic link between the hyperandrogenism and insulin resistance that characterize the polycystic ovary syndrome. | 7479852 |
| Eyelid Xanthoma, Dyslipidemias | Deregulated Nutrient Sensing | To know the prevalence and types of dyslipidemia associated with xanthelasma. | 7485205 |
| Eyelid Xanthoma, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The findings support the notion that xanthelasma is a marker of dyslipidemia, and underline the need to determine a full lipid profile in these patients to detect those potentially at increased risk of cardiovascular disease. | 7485205 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The relation between the C-peptide concentration in twenty-four-hour urine specimens and atherogenic risk factors was investigated in 38 patients with noninsulin-dependent diabetes mellitus in an attempt to determine the significance of urine C-peptide in diagnosing "syndrome X," which is characterized by insulin resistance. | 7486212 |
| Obesity | Deregulated Nutrient Sensing | The beta 3AR may be one of the loci contributing to obesity and hyperinsulinemia/insulin resistance in Japanese subjects. | 7487991 |
| Hyperinsulinism, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Although insulin sensitivity was not measured, fasting hyperinsulinaemia in NSY mice suggests that insulin resistance may also contribute to the pathogenesis of NIDDM. | 7489831 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | According to data on the accumulation of atherogenic risks (hypertension, dyslipidaemia, and smoking), IMT increased linearly in non-IGT and IGT subjects. | 7489842 |
| Hyperinsulinism, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinaemia in mild to moderate progressive chronic renal failure and its association with aerobic work capacity. | 7489839 |
| Glucose Intolerance (disease), Overweight, Obesity | Deregulated Nutrient Sensing | The prevalence of overweight or obesity increased, and the rates of glucose intolerance changed little. | 7496233 |
| Diabetes Mellitus, metabolic disturbance, Obesity | Deregulated Nutrient Sensing | The risk of diabetes increased with the increased central obesity and metabolic disturbances associated with insulin resistance. | 7497867 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | In conclusion, our results indicate that in nonobese hypertensive patients, insulin resistance does not have any influence on the 24-hour blood pressure profile or on left ventricular mass index. | 7498973 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | High intracellular calcium can cause insulin resistance, as seen in non-insulin-dependent diabetes mellitus (NIDDM) patients. | 7518543 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Our data indicate that elevated PHF may be responsible for insulin resistance in a fraction of NIDDM patients and suggest that PHF may be related to serum cholesterol levels in NIDDM. | 7518543 |
| Renal Insufficiency, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Renal dysfunction and glucose intolerance appeared when the blood level of FK506 was high. | 7526689 |
| Glucose Intolerance (disease), Neoplasms | Deregulated Nutrient Sensing | Curative resection ameliorates glucose intolerance, while tumor persistence can enhance serum glucose levels. | 7532931 |
| Angiosarcoma of liver, Insulin-resistant diabetes mellitus | Deregulated Nutrient Sensing | [Coincidence of hepatic angiosarcoma and insulin-resistance diabetes mellitus with high-dose intraperitoneal insulin therapy]. | 7534000 |
| diabetic | Deregulated Nutrient Sensing | In six type 2 diabetic subjects and a subject with type A insulin resistance, islet amyloid deposits were reactive to anti-IAPP8-17 antibody, but not to anti-N-terminal and C-terminal flanking peptide antibodies. | 7535678 |
| Increased insulin level, Dyslipidemias, Non-insulin Hypoglycemic, Diabetes Mellitus | Deregulated Nutrient Sensing | [Dyslipidemia and hyperinsulinemia in normoglycemic-obese relatives of patients with non-insulin dependent diabetes mellitus]. | 7548306 |
| Coronary heart disease | Deregulated Nutrient Sensing | Both the insulin resistance syndrome and phenotype B have also been related to increased risk of coronary heart disease. | 7550534 |
| Increased insulin level, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance. | 7554195 |
| Increased insulin level, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | Insulin resistance, hyperinsulinemia, and myocardial hypertrophy frequently coexist in patients. | 7554195 |
| Hypothalamic Dysfunction Syndromes, Hypogonadotropic hypogonadism | Deregulated Nutrient Sensing | Isolated combined growth hormone and gonadotrophin deficiency due to hypothalamic dysfunction, associated with insulin resistance. | 7554320 |
| Hyperlipidemia, Hypogonadotropic hypogonadism | Deregulated Nutrient Sensing | The presence of congenital combined growth hormone and gonadotrophin deficiency on the basis of a suprapituitary defect suggests the existence of common or related pathways regulating GnRH and GHRH synthesis or secretion and may have contributed to the ultimate development of insulin resistance and hyperlipidaemia. | 7554320 |
| Dyslipoproteinemias, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Japanese men with glucose intolerance frequently have small LDL, and this abnormality is associated with other dyslipoproteinemias and increased waist-to-hip ratio. | 7555476 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance is associated with high plasma ouabain-like immunoreactivity concentration in NIDDM. | 7556980 |
| Hypertensive (finding), NEUROD1 wt Allele | Deregulated Nutrient Sensing | Six of 57 NIDDM patients studied exhibited very high (> 1500 pmol/l) plasma OLI concentrations, showed marked insulin resistance and were all hypertensive. | 7556980 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These results indicate that hypertension is independently associated with glucose tolerance and insulin resistance in three Caucasian cohorts. | 7556987 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | [Blood insulin in fasting conditions as a simple marker of insulin resistance in hypertensive patients]. | 7569442 |
| Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is associated to hypertension, obesity and diabetes and may be an independent cardiovascular risk factor. | 7569442 |
| Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore pharmacological interventions should aim to improve insulin sensitivity. | 7575750 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Both groups were comparable in age, body-mass index and duration of diabetes and had a similar degree of insulin resistance at baseline. | 7575750 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM. | 7589821 |
| Hyperlipidemia | Deregulated Nutrient Sensing | However, patients with antibodies against endothelial cell and/or cardiolipin had a lower prevalence of hyperlipidaemia/dyslipidaemia when compared to patients without these antibodies (P < 0.05). | 7595183 |
| Hyperlipidemia, Blood Vessel | Deregulated Nutrient Sensing | The lower occurrence of hyperlipidaemia/dyslipidaemia in patients with autoantibodies, in comparison to patients without the antibodies, suggests that these antibodies have a role in vascular damage. | 7595183 |
| Werner Syndrome | Deregulated Nutrient Sensing | These results demonstrate that insulin resistance in the patient with Werner's syndrome is caused by a defect that cannot be detected by means employed in this study, and suggest that the defect is present at the steps distal to the autophosphorylation of tyrosine kinase of insulin receptors. | 7599691 |
| diabetic | Deregulated Nutrient Sensing | An association between insulin resistance and blood pressure levels has been found both in non-diabetic subjects and in type 2 diabetic patients. | 7599758 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Prevalence and correction of hypothyroidism in a large cohort of patients referred for dyslipidemia. | 7605150 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | All patients referred for diagnosis and treatment of dyslipidemia should be screened for hypothyroidism by measurement of thyrotropin values. | 7605150 |
| Obesity, Abdominal, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The Trp64Arg allele of the beta 3-adrenergic receptor is associated with abdominal obesity and resistance to insulin and may contribute to the early onset of NIDDM: | 7609751 |
| Dyslipidemias | Deregulated Nutrient Sensing | In type IV dyslipidaemia LDL-C may increase moderately. | 7612280 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | Several risk factors for the development of microalbuminuria such as: blood glucose unbalance, high blood pressure, dyslipidemia, genetic susceptibility have been described and discussed. | 7613502 |
| Obesity | Deregulated Nutrient Sensing | Recent studies have shown that central obesity (increased waist to hip ratio [WHR]) is related to insulin resistance and aging. | 7616857 |
| Sleep Apnea, Obstructive, Hypertension, CTCAE | Deregulated Nutrient Sensing | [Glucose tolerance, insulin resistance and arterial hypertension in patients with obstructive sleep apnea syndrome]. | 7617595 |
| Sleep Apnea, Obstructive, Overweight, Hypertension, CTCAE | Deregulated Nutrient Sensing | The reduced glucose tolerance and increased insulin resistance in combination with arterial hypertension in this patient group is indicative that a combination of adiposity and OSAS represents a particularly high risk factor for the development of arterial hypertension even though the pathological mechanism responsible for the development of arterial hypertension is also present in members of both the normal weight OSAS group and the overweight group without OSAS who exhibit a metabolic predisposition for the development of hypertension. | 7617595 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. | 7623569 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | [Increase of gamma-glutamyltranspeptidase in patients with compensated hypoalphalipoproteinemia and type IIa dyslipidemias]. | 7627821 |
| Coronary heart disease | Deregulated Nutrient Sensing | Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity-insulin resistance syndrome. | 7631632 |
| Atherosclerosis | Deregulated Nutrient Sensing | The data suggest that serum uric acid may be involved in the obesity-insulin resistance syndrome, which in turn may explain the relation of serum uric acid to coronary atherosclerosis. | 7631632 |
| Glucose Intolerance (disease), Cardiac Arrhythmia | Deregulated Nutrient Sensing | Glucose intolerance, cardiac arrhythmia, and estrogen replacement therapy were not significant predictors. | 7631731 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | There has been much debate concerning the relative contribution of insulin resistance to the development of polycystic ovaries (PCO). | 7634500 |
| Hyperinsulinism, diabetic | Deregulated Nutrient Sensing | This suggests that body mass is a more important determinant of BMD than hyperinsulinaemia or insulin resistance in diabetic women. | 7638560 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Due to the fact that similar data were obtained for type II diabetic patients, an unknown relation to insulin resistance might be the underlying cause and should be further investigated. | 7645365 |
| Glucose Intolerance (disease), Demographics Domain | Deregulated Nutrient Sensing | Furthermore the potential for DM to increase with age, as has been suggested before, has been evaluated using the IGT as a proportion of total glucose intolerance (IGT/TGI) for the same parts of the tested sample. | 7648801 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude, that physiologically elevated levels of FFa could potentially be responsible for a large part of the peripheral insulin resistance in patients with non-insulin-dependent diabetes mellitus. | 7657800 |
| Hypertension, CTCAE, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance that exists in patients with essential hypertension and in those with non-insulin-dependent diabetes mellitus (NIDDM) may be the common denominator for the impaired glucose homeostasis and elevated blood pressure (BP) levels in patients with NIDDM. | 7662219 |
| Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In spite of the potential benefits of reversal of insulin resistance and weight reduction, altering therapy of type II diabetes mellitus from insulin to tolazamide may increase blood pressure, thereby increasing cardiovascular risk. | 7662230 |
| Laryngoonychocutaneous syndrome | Deregulated Nutrient Sensing | Insulin resistance syndrome in postmenopausal women with cardiological syndrome X. | 7662453 |
| Congenital Abnormality | Deregulated Nutrient Sensing | Women with syndrome X tend to be insulin resistant and have lipid and lipoprotein abnormalities, but do not exhibit all characteristics of the insulin resistance syndrome. | 7662453 |
| Acanthosis Nigricans, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Association of acanthosis nigricans with insulin resistance in patients with polycystic ovary syndrome. | 7662572 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | This study was designed to explore the association of insulin resistance and acanthosis nigricans (AN) in patients with polycystic ovary syndrome (PCOS). | 7662572 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | These findings support the view that obese PCOS patients with AN do not have significantly higher insulin resistance than obese patients without AN. | 7662572 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Insulin resistance is a necessary, but not the only, factor leading to the development of AN in patients with PCOS. | 7662572 |
| Microalbuminuria | Deregulated Nutrient Sensing | Longitudinal study of associations of microalbuminuria with the insulin resistance syndrome and sodium-lithium countertransport in nondiabetic subjects. | 7670946 |
| Microalbuminuria, Myocardial Ischemia, diabetic | Deregulated Nutrient Sensing | Microalbuminuria in diabetic patients is associated with ischemic heart disease and insulin resistance. | 7670946 |
| Chronic Obstructive Airway Disease, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Associated diseases were: hypertension (45%), diabetes (40%), dyslipidemia (29%), chronic obstructive lung disease (6%). | 7671273 |
| Peripheral arterial occlusive disease | Deregulated Nutrient Sensing | [Incidence of insulin resistance in peripheral arterial occlusive disease patients. | 7672743 |
| Obesity | Deregulated Nutrient Sensing | Epidemiologic study of central obesity, insulin resistance and associated disturbances in the urban population of North India. | 7676761 |
| Coronary Artery Disease, Obesity | Deregulated Nutrient Sensing | Central obesity in association with insulin resistance is a strong predictor of coronary artery disease (CAD) in South Asians; however the prevalence of central obesity and insulin resistance in Indians are unknown. | 7676761 |
| Obesity | Deregulated Nutrient Sensing | These findings indicate the existence of a modest degree of insulin resistance with a modest tendency to central obesity in the urban population of North India. | 7676761 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of glucose intolerance, diabetes mellitus, hypertension, hypertriglyceridemia and CAD were significantly higher in the higher quintiles of WHR above 0.88 compared to lower quintiles. | 7676761 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance may play a role in the pathogenesis of essential hypertension. | 7677082 |
| Hyperlipidemia, Glucose Intolerance (disease), Hypertension, CTCAE, Atherosclerosis | Deregulated Nutrient Sensing | Excess free fatty acid may cause the enhancement of lipid synthesis and gluconeogenesis as well as insulin resistance, resulting in hyperlipidemia, glucose intolerance, and hypertension and finally atherosclerosis. | 7695182 |
| Dyslipidemias, Diabetes Mellitus, Heart failure, Simultaneous, Obesity | Deregulated Nutrient Sensing | The percentage of patients with concomitant diseases (dyslipidemia, diabetes, obesity, cardiac failure) is very high. | 7709040 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project. | 7712700 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Transient neonatal diabetes and later onset diabetes: a case of inherited insulin resistance. | 7717741 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Both her mother and sister had profound insulin resistance; neither had clinical diabetes. | 7717741 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This is the first time inherited insulin resistance has been implicated in the pathogenesis of permanent diabetes developing after transient neonatal diabetes. | 7717741 |
| Hypercholesterolemia, Dyslipidemias, Hyperlipidemia | Deregulated Nutrient Sensing | Metabolism of low density lipoproteins in nephrotic dyslipidemia: comparison of hypercholesterolemia alone and combined hyperlipidemia. | 7723244 |
| Nephrons, Dyslipidemias, Hyperlipidemia | Deregulated Nutrient Sensing | Another pattern of dyslipidemia in nephrotic patients is an elevation of both cholesterol and triglyceride levels (combined hyperlipidemia). | 7723244 |
| Dyslipidemias | Deregulated Nutrient Sensing | It has been postulated that the underlying cause of nephrotic dyslipidemia is an hepatic overproduction of apolipoprotein B (apo B)-containing lipoproteins. | 7723244 |
| Dyslipidemias | Deregulated Nutrient Sensing | These data indicate that the metabolism of LDL is strikingly different between the two forms of nephrotic dyslipidemia. | 7723244 |
| Cardiac complication, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | In addition to the typical dyslipidaemia found in CAPD patients, high levels of Lp(a) and specific isoform patterns may in turn contribute to the elevated risk of coronary artery disease and other cardiovascular complications. | 7724034 |
| Non-insulin Hypoglycemic | Deregulated Nutrient Sensing | [Insulin resistance and combined therapy with sulfonylurea and insulin in non-insulin dependent diabetics]. | 7725640 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Results suggest that body mass index, physical inactivity, glucose level, and parental diabetes appear to be independent risk factors for diabetes, while triglyceride and systolic blood pressure levels may be markers for an adverse cardiovascular risk factor profile associated with diabetes and may reflect an insulin resistance syndrome. | 7728283 |
| Glucose Intolerance (disease), Traumatic injury | Deregulated Nutrient Sensing | These findings have implications for care: the elderly trauma patient will be weaker than a younger counterpart, and nutrition will need to be provided early, with the glucose intolerance of elderly people borne in mind. | 7728694 |
| Hyperlipidemia, Microvascular Angina | Deregulated Nutrient Sensing | [The significance of insulin resistance and hyperlipidemia in microvascular angina (syndrome X)]. | 7732710 |
| Hyperlipoproteinemias | Deregulated Nutrient Sensing | These findings suggest a pathogenetic role of insulin resistance, hyperlipoproteinemia and elevated levels of fibrinogen for impaired myocardial coronary reserve. | 7732710 |
| Werner Syndrome | Deregulated Nutrient Sensing | These results suggest that the patients with Werner's syndrome express normal insulin receptors and that the primary genetic lesion for insulin resistance is not in the insulin receptor gene. | 7736897 |
| Werner Syndrome | Deregulated Nutrient Sensing | Insulin resistance in Werner's syndrome is thus likely by a post-receptor defect. | 7736897 |
| Postprandial hyperlactemia | Deregulated Nutrient Sensing | It is suggested that postprandial hyperlipidaemia is a characteristic trait of the insulin resistance syndrome and that the defect in lipid removal is related to the low HDL cholesterol in this syndrome. | 7738484 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The insulin resistance syndrome is likely to be an important reason for the increased propensity for cardiovascular disease in smokers. | 7738484 |
| Kidney Failure, Chronic, Electronic Source Report Form | Deregulated Nutrient Sensing | Patients with end-stage renal failure (ESRF) on dialysis treatment have increased insulin resistance which is associated with hypersecretion of beta-cell products. | 7738722 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes and glucose intolerance have been shown to increase the risk of cardiovascular mortality in a number of different populations. | 7743621 |
| Glucose Intolerance (disease), Sudden death, Diabetes Mellitus | Deregulated Nutrient Sensing | The relations seen in these analyses indicate that individuals with glucose intolerance or diagnosed diabetes are at increased risk for sudden death. | 7743621 |
| Increased insulin level | Deregulated Nutrient Sensing | Relation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia. | 7749841 |
| Lipemia - observation | Deregulated Nutrient Sensing | We examined the relation between insulin resistance, plasma glucose and insulin responses to meals, lipoprotein lipase (LPL) activity, and postprandial lipemia in a population of 37 healthy nondiabetic individuals. | 7749841 |
| Steatohepatitis, Hyperinsulinism, Hypertension, CTCAE | Deregulated Nutrient Sensing | Association between hepatic steatosis, insulin resistance and hyperinsulinaemia as related to hypertension in alcohol consumers and obese people. | 7752170 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Overweight | Deregulated Nutrient Sensing | In overweight women with polycystic ovary syndrome (PCOS), increased insulin resistance has been observed. | 7752909 |
| Spinal Cord Injuries, Depressed mood, Dyslipidemias | Deregulated Nutrient Sensing | Several reports indicate that dyslipidemia, primarily depressed high density lipoprotein cholesterol, is common in persons with spinal cord injury. | 7753565 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Dietary change and obesity associated with glucose intolerance in Alaska Natives. | 7759744 |
| Increased insulin level, Obesity | Deregulated Nutrient Sensing | Several dominant mutations at the agouti locus in the mouse cause a syndrome of marked obesity, hyperinsulinemia, and insulin resistance. | 7761392 |
| Obesity | Deregulated Nutrient Sensing | To examine whether increased PTPase activity is associated with adipose tissue insulin resistance in human obesity we measured PTPase enzyme activity towards the insulin receptor in homogenates of subcutaneous adipose tissue from a series of six lean and six nondiabetic, obese (body mass index > 30) subjects. | 7769120 |
| Obesity | Deregulated Nutrient Sensing | These studies suggest that increased PTPase activity towards the insulin receptor is a pathogenetic factor in the insulin resistance of adipose tissue in human obesity and provide evidence for a potential role of the LAR PTPase in the regulation of insulin signalling in disease states. | 7769120 |
| Infarction, Hypercholesterolemia, Dyslipidemias, Occlusion of artery (disorder) | Deregulated Nutrient Sensing | CT-scan and MRI suggested temporal-parietal infarction due to Sylvian artery occlusion in a 9-month-old infant with familial hypercholesterolemia (type 2 A dyslipidemia). | 7779744 |
| Weight Gain | Deregulated Nutrient Sensing | to investigate whether increased insulin resistance is associated with a reduced risk of weight gain among Hispanic and non-Hispanic white persons in Colorado. | 7780493 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The association of hypertension with insulin resistance has been reported. | 7794582 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These results suggest that insulin resistance or plasma insulin level plays a role in the pathogenesis of essential hypertension. | 7794582 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Insulin resistance was presumed to develop in normal glucose tolerance subjects with hyperinsulinaemia. | 7806019 |
| Chronic kidney disease stage 5, Dyslipidemias, physiopathological | Deregulated Nutrient Sensing | Dyslipidemia is one of the first metabolic dysfunction observed among patients with end stage renal disease. | 7808932 |
| Dyslipidemias | Deregulated Nutrient Sensing | The findings are consistent with the hypothesis that in CESD increased intrahepatic synthesis of cholesterol stimulates hepatic secretion of VLDL apoB and this may partly account for the dyslipidemia. | 7813057 |
| Hyperinsulinism | Deregulated Nutrient Sensing | The present study provides further evidence that a relationship exists between blood pressure and hyperinsulinaemia or insulin resistance. | 7814857 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | CONCLUSIONS--This study highlights the high prevalence of glucose intolerance in elderly south Indians having low mean BMI (mean +/- SD; urban 21.7 +/- 4.6, rural 17.9 +/- 3.3 kg/m2). | 7821141 |
| Hyperinsulinism, Data types - Address, Overweight | Deregulated Nutrient Sensing | We conclude that patients with AD have hyperinsulinaemia and insulin resistance, and this may be secondary to being overweight but a causal relationship cannot be excluded. | 7825486 |
| Hepatosplenomegaly, Hypereosinophilia, Diabetic Ketoacidosis | Deregulated Nutrient Sensing | Due to the progression of hypereosinophilia, hepatosplenomegaly and peripheral lymphoadenopathy, severe insulin resistance associated with diabetic ketoacidosis occurred repeatedly, despite intravenous administration of over 1,000 U per day of human insulin. | 7827382 |
| Diabetes Mellitus, Coronary heart disease | Deregulated Nutrient Sensing | Diabetes mellitus caused by insulin resistance significantly contributes to early coronary heart disease in South Asian immigrant patients, in accordance with the literature on the present population of India. | 7830825 |
| Atherosclerosis | Deregulated Nutrient Sensing | These findings strengthen the belief that genetic factor are important in the development of insulin resistance and atherosclerosis. | 7830825 |
| Cancer-related fatigue, Acidosis, Chronic Kidney Diseases | Deregulated Nutrient Sensing | To test the hypothesis that acidosis contributes to the insulin resistance of chronic renal failure (CRF) and impairs the action of insulin to decrease protein degradation, eight CRF patients were studied using the combined L-[1-13C]leucine-euglycemic clamp technique before (acid) and after (NaHCO3) 4 wk treatment with NaHCO3 (pH: acid 7.29 +/- 0.01 vs. NaHCO3 7.36 +/- 0.01, P < 0.001). | 7840169 |
| Cancer-related fatigue, Acidosis, palladium | Deregulated Nutrient Sensing | In conclusion, acidosis contributes to the insulin resistance of CRF but does not affect the action of insulin on PD. | 7840169 |
| Hypertension, CTCAE, Turner Syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Turner syndrome is associated with insulin resistance, increased incidence of type II diabetes, and hypertension, all of which are cardiovascular risk factors. | 7844670 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Clinical and laboratory studies showed that plasmasorption used in multiple-modality treatment helps effectively control a purulent process, reduces intoxication of the body, corrects the development of insulin resistance in patients with maxillofacial phlegmons coursing in the presence of diabetes mellitus. | 7846708 |
| Hypertension, CTCAE, Liver Cirrhosis, diabetic | Deregulated Nutrient Sensing | [Decrease of insulin resistance after splenectomy in a diabetic patient with liver cirrhosis and portal hypertension. | 7849151 |
| Glucose Intolerance (disease), Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Liver cirrhosis is characterized by an increased incidence of glucose intolerance, diabetes and insulin resistance. | 7849151 |
| Cardiovascular Diseases, diabetic | Deregulated Nutrient Sensing | Relationship between insulin resistance and risk factors for cardiovascular disease in Japanese non-insulin-dependent diabetic patients. | 7851274 |
| Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, diabetic, Complications of Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To investigate whether a resistance to insulin-stimulated glucose uptake (IR) is associated with the risk factors (RF) for cardiovascular disease (CVD) in non-insulin-dependent diabetic (NIDDM) patients, we determined the degree of IR in 135 adult NIDDM patients who had no advanced diabetic complications. | 7851274 |
| Weight decreased | Deregulated Nutrient Sensing | The results clearly showed the vigorous weight reduction conducted the significant decrease of the insulin resistance as well as normalizations of blood pressures and several biochemical parameters. | 7851833 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Our experience from the case suggested that insulin resistance may closely related with the metabolic disorders of the disease "syndrome X". | 7851834 |
| Microalbuminuria, Hypertensive (finding) | Deregulated Nutrient Sensing | To examine whether microalbuminuria in non-diabetic, treated hypertensive men is associated with insulin resistance and measures of endothelial function, thrombogenesis and fibrinolysis. | 7852923 |
| Microalbuminuria, Obesity | Deregulated Nutrient Sensing | Microalbuminuria was associated with insulin resistance but obesity was a confounding factor. | 7852923 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Dyslipidaemias in white and black treated essential hypertensive patients. | 7853326 |
| Glucose Intolerance (disease), Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Plasma lipid abnormalities and risk factors for coronary artery disease in Japanese subjects with diabetes mellitus and glucose intolerance. | 7859608 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We suggest that a westernized lifestyle induces peripheral insulin resistance and promotes the development of diabetes among Japanese. | 7859631 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | By the cooperation of members of the Japan Diabetes Society, we collected data on 144 twin pairs with diabetes or glucose intolerance. | 7859635 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Comparison of groups with varying degrees of glucose intolerance revealed that a family history of diabetes increased in parallel with the impairment of glucose tolerance. | 7859636 |
| Glucose Intolerance (disease), metabolic disturbance | Deregulated Nutrient Sensing | Glucose intolerance was also associated with increased blood glucose concentration during the OGTT and with other metabolic disturbances such as increased serum lipids, increased blood pressure, and physical inactivity. | 7863144 |
| Glucose Intolerance (disease), Liver Cirrhosis | Deregulated Nutrient Sensing | Glucose intolerance in liver cirrhosis: role of hepatic and non-hepatic influences. | 7865613 |
| Glucose Intolerance (disease), Cholestasis, Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no association between glucose intolerance or diabetes and the aetiology of cirrhosis, the duration of the disease, the biochemical indicators of hepatocyte damage, cholestasis and/or liver function. | 7865613 |
| Hepatobiliary Disorder, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | After manifestation of liver disease, glucose intolerance or diabetes cannot be explained by the clinical, histological or biochemical signs of liver disease. | 7865613 |
| Uremia, Glucose Intolerance (disease), Hyperparathyroidism, Secondary | Deregulated Nutrient Sensing | Before calcitriol treatment, uraemic patients with secondary hyperparathyroidism displayed a significant higher triglyceride and a significant lower HDL-C and apoprotein A-I as well as marked glucose intolerance with an increment of the area below the glucose curve when compared with healthy control subjects. | 7874841 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Diabetes was associated with advanced age, had a greater impact in the low-income group, and showed increased odds ratio for hypertension, dyslipidemias, and myocardial infarction in men and women and for obesity only in women. | 7882814 |
| Glucose Intolerance (disease), NEUROD1 wt Allele | Deregulated Nutrient Sensing | Consumption of seal oil and salmon, high in omega-3 fatty acids, appears to lower the risk of glucose intolerance and is a potentially modifiable risk factor for NIDDM in Alaska Natives. | 7882827 |
| Increased insulin level, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Hyperinsulinemia, which is considered a hallmark of insulin resistance, precedes the development of non-insulin-dependent diabetes mellitus (NIDDM). | 7883115 |
| Dyslipidemias | Deregulated Nutrient Sensing | Although heterozygosity for apo E1 alone did not impair the interaction of VLDL with cellular receptors in vitro, its presence in subjects with type III HLP suggests that apo E1, perhaps in combination with secondary factors, may be causative for the dyslipidemia. | 7883834 |
| Increased insulin level, Hyperlipidemia, Atherosclerosis, Insulin resistance syndrome, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | There is the accumulating evidence that chronic day-long hyperinsulinemia is associated with an insulin-resistance syndrome characterized by the development of hypertension, hyperlipidemia, atherosclerosis and non insulin depend diabetes. | 7885957 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | This finding suggests that regular aerobic exercise may prevent the age-associated increase in abdominal obesity and insulin resistance. | 7900795 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that long-term therapy with terazosin may improve glucose and lipid metabolism in hypertensive patients and terazosin seems to be an antihypertensive agent with beneficial effects for hypertensive patients with either dyslipidemia or impaired glucose metabolism. | 7908168 |
| Coronary heart disease | Deregulated Nutrient Sensing | We investigated the association between fasting insulin concentration--an indicator of insulin resistance in nondiabetic individuals--cardiovascular risk factors, and coronary heart disease in a study of 390 men in the town of Zutphen. | 7918315 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | These results suggest that perindopril can be used effectively to treat hypertension in patients with glucose intolerance without affecting glucose and lipid metabolism. | 7923313 |
| Triglycerides | Deregulated Nutrient Sensing | Insulin resistance and hypertriacylglycerolaemia are part of the X syndrome and are supposed to be interrelated. | 7923327 |
| Triglycerides | Deregulated Nutrient Sensing | Hypertriacylglycerolaemia exists as an independent factor which is rather the consequence than cause of insulin resistance. | 7923327 |
| Dyslipidemias | Deregulated Nutrient Sensing | The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred. | 7923858 |
| Coronary Arteriosclerosis, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Evidence of higher insulin resistance in NIDDM patients with ischaemic heart disease. | 7926345 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In NIDDM this association is less clear possibly due to the poor significance of insulin and C-peptide concentrations as an index of insulin resistance. | 7926345 |
| Myocardial Ischemia, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Therefore, only a direct measurement of insulin sensitivity could clarify the possible relationship between insulin resistance and IHD in NIDDM. | 7926345 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Aspects of insulin resistance in urbanisation-related hypertension in Zimbabwe: a preliminary report. | 7932509 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Insulin resistance has been associated with essential hypertension, obesity and old age. | 7932509 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These findings suggest that insulin resistance may play a role in urbanisation-related hypertension. | 7932509 |
| Hypertriglyceridemia, Obesity, diabetic | Deregulated Nutrient Sensing | Insulin resistance is associated with hypertriglyceridemia and elevated free fatty acid (FFA) concentrations in obese and diabetic individuals, but it is unclear to what extent this relationship is independent of obesity and is present in healthy individuals. | 7934980 |
| glycation, Dyslipidemias, Kidney Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency. | 7937786 |
| Hyperthyroidism, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | During the day abnormally high postprandial blood glucose levels were seen, pointing to the glucose intolerance usually seen in the hyperthyroid state. | 7941923 |
| Hyperthyroidism, Glucose Intolerance (disease), insulinoma, Hypoglycemia | Deregulated Nutrient Sensing | As shown in this case, concurrent hyperthyroidism and an insulinoma may lead to consecutive episodes of glucose intolerance and hypoglycemia within the same 24-hour period. | 7941923 |
| No metabolic abnormalities, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of a new oral hypoglycaemic agent (CS-045) on metabolic abnormalities and insulin resistance in type 2 diabetes. | 7955995 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | [The role of beta 2-adrenoceptor on the pathogenesis of insulin resistance in essential hypertension]. | 7958101 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The role of beta 2-adrenoceptor on the pathogenesis of insulin resistance in essential hypertension (EH) was explored. | 7958101 |
| Increased insulin level | Deregulated Nutrient Sensing | In addition, hyperinsulinemia was observed during the 75g glucose tolerance test and the presence of insulin resistance was suggested. | 7959530 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Hyperglycemia and glucose intolerance are characteristic of both the metabolic responses to injury and normal aging. | 7966476 |
| Apolipoprotein E, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. | 7966894 |
| Apolipoprotein E, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Apolipoprotein E alleles are important genetic markers for dyslipidemia and CHD. | 7966894 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | It was concluded that acanthosis nigricans is highly prevalent among Native Americans and that its presence suggests insulin resistance. | 7977931 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | The findings suggest that obesity and cigarette smoking are important factors in the development of glucose intolerance in middle-aged Japanese men. | 7981843 |
| Increased insulin level | Deregulated Nutrient Sensing | In short-term studies (4 to 6 months) we have reported that antihypertensive treatment with beta-adrenergic blockade and thiazide diuretics induced insulin resistance, hyperinsulinemia, and a deranged lipid profile; the ACE inhibitor captopril increased insulin sensitivity without affecting serum lipids. | 7985599 |
| Werner Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Previous reports suggest that insulin resistance is involved in the development of diabetes associated with Werner's syndrome. | 7988348 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Glucose intolerance was associated with high triglyceride, low HDL cholesterol and central obesity in European but not in Afro-Caribbean men. | 7988778 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The pathophysiology of noninsulin-dependent diabetes mellitus (NIDDM) is characterized by insulin resistance and insulin deficiency. | 7989470 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Essential hypertension is frequently associated with insulin resistance and hyperinsulinemia. | 7995624 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | It is concluded that salt restriction may increase insulin resistance in hypertensive patients. | 7997846 |
| Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Patients with non-insulin-dependent diabetes mellitus (NIDDM) exhibit insulin resistance and decreased glucose transport in skeletal muscle. | 8013748 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | The newly-diagnosed NIDDM patients mostly suffered from diseases related to the insulin resistance syndrome, and we thus recommend measurement of non-fasting blood-glucose as a screening procedure in such patients. | 8016951 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most common risk factors in the young group were dyslipidemia (67%) and cigarette smoking (65%), and in the octogenarian group were dyslipidemia (52%) and hypertension (50%). | 8021047 |
| Primary malignant neoplasm, Weight decreased, Neoplasms | Deregulated Nutrient Sensing | Effects of tumor removal and body weight loss on insulin resistance in patients with cancer. | 8023270 |
| Weight decreased, Neoplasms | Deregulated Nutrient Sensing | This study was conducted to evaluate the effects of tumor removal and body weight loss on insulin resistance. | 8023270 |
| Primary malignant neoplasm, Malnutrition, Neoplasms | Deregulated Nutrient Sensing | Our results would suggest that insulin resistance in patients with cancer was not caused by cancer-associated malnutrition but at least in part by tumor itself. | 8023270 |
| Glucose Intolerance (disease), Fibrosis Assessment, Beta-cell dysfunction | Deregulated Nutrient Sensing | Roles of insulin resistance and beta-cell dysfunction in the pathogenesis of glucose intolerance in cystic fibrosis. | 8027259 |
| deficiency aspects, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We conclude that 1) glycohemoglobin is a strong correlate of insulin deficiency in CF; and 2) glucose intolerance in this group of CF patients occurred as a consequence of concomitant insulin deficiency and insulin resistance. | 8027259 |
| Impaired, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | In conclusion obesity causes not only glycemic impairment, but also atherogenic alterations of plasma lipidic parameters "per se" and/or through insulin-resistance; therefore it must be considered a pathologic condition or, at least, a risk factor of cardio-vascular diseases and treated with the greatest care. | 8028743 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Serum calcium increased glucose intolerance from 1.76 to 2.0, 2.08, 1.96 and 2.0 mmol/l, respectively; vitamin D reached supraphysiological levels initially and returned to normal levels, and parathyroid hormone levels were normalized. | 8029165 |
| Neuropathy, Dyslipidemias, Retinal Diseases, Kidney Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | As a group these prisoners were obese with a high prevalence of smoking, hypertension, dyslipidaemia, retinopathy, nephropathy and neuropathy. | 8035969 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | had a high percentage of risks factors (diabetes mellitus 55%, nicotinism 85%, dyslipidemia 22.5%) and history of previous myocardial infarction in 33% of cases. | 8038989 |
| Uremia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Disturbance in the vitamin D/parathyroid hormone (PTH) axis may be important in the pathogenesis of glucose intolerance and insulin resistance in uraemia. | 8041868 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | We found that LVH in men is associated with indices of enhanced sympathetic nervous system reactivity and with elevated fasting insulin and triglyceride levels, which may be caused by insulin resistance. | 8044964 |
| Left Ventricular Hypertrophy, Hypertension, CTCAE, Hyperkinetic | Deregulated Nutrient Sensing | We suggest that early LVH in young men is a manifestation of hyperkinetic borderline hypertension, a state previously shown to be associated with increased sympathetic nervous system activity and insulin resistance. | 8044964 |
| Coronary heart disease | Deregulated Nutrient Sensing | It recently has been hypothesized that increased plasma plasminogen activator inhibitor-1 (PAI-1) activity could be a possible link between insulin resistance and coronary heart disease. | 8049187 |
| Cardiac complication, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Peripheral, rather than hepatic, insulin resistance and atherogenic lipoprotein phenotype predict cardiovascular complications in NIDDM. | 8050454 |
| Microalbuminuria, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | A cross-sectional study from our Department showed that peripheral insulin resistance, hypertension, microalbuminuria and lipid abnormalities are associated in NIDDM. | 8050454 |
| Extrahepatic, Hyperinsulinism | Deregulated Nutrient Sensing | However, it is unknown to what extent hyperinsulinaemia reflects resistance to insulin action at hepatic, extrahepatic or at both sites. | 8050454 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cholestyramine therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. | 8053615 |
| Dyslipidemias, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To assess clinical efficacy and tolerability of cholestyramine therapy in patients with dyslipidemia and non-insulin-dependent diabetes mellitus (NIDDM). | 8053615 |
| Increased insulin level, diabetic | Deregulated Nutrient Sensing | Known and newly diagnosed diabetic patients were excluded from this study, since serum insulin and C-peptide levels are indicators of insulin resistance and hyperinsulinemia in non-diabetics only. | 8059770 |
| Increased insulin level, Overweight | Deregulated Nutrient Sensing | Besides overweight, physical activity and dietary factors such as the intake of fatty acids, fiber, carbohydrates, and alcohol, were independently associated with hyperinsulinemia and insulin resistance. | 8059770 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with non-insulin-dependent diabetes mellitus (NIDDM) are at high risk of cardiovascular disease for many reasons and especially due to the fact that dyslipidemias are more frequent in this group of patients. | 8067175 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance--not hyperinsulinemia--is pathogenic in essential hypertension. | 8072428 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | A correlation between essential hypertension and insulin resistance/hyperinsulinemia is well documented, and there is adequate reason to believe that this association is causal. | 8072428 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Correction of insulin resistance usually aids blood pressure control, and in addition may mitigate the excess cardiovascular risk associated with hypertension. | 8072428 |
| diabetic | Deregulated Nutrient Sensing | To study the effect of insulin and sulfonylurea (SU) therapy on glycaemic control, insulin resistance and cardiovascular risk factors in type 2 diabetic subjects. | 8077888 |
| Hyperlipidemia, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | [Prevalences of diabetes, glucose intolerance, hyperlipemia and risk factors as a function of socioeconomic level]. | 8079061 |
| Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Despite the significant role that dyslipidemia is believed to play in the development of cardiovascular disease in diabetes, most studies examining diabetic dyslipidemia in the United States have not been population based, and very little data are available for African Americans with diabetes. | 8087927 |
| Dyslipidemias, atherosclerotic, NEUROD1 wt Allele | Deregulated Nutrient Sensing | In African-American and white men and women in the United States, NIDDM is associated with a pattern of dyslipidemia that may potentiate the atherosclerotic process. | 8087927 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Diabetic treatment should include aggressive treatment of dyslipidemia to reduce this increased risk. | 8087927 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Whole body glucose use was 55% lower in patients than in control subjects (17 +/- 3 mumol/kg/minute versus 38 +/- 3 mumol/kg/minute, P = 0.002), consistent with insulin resistance in cancer. | 8111717 |
| Glucose Intolerance (disease), Liver Cirrhosis | Deregulated Nutrient Sensing | In conclusion, glucose intolerance in cirrhosis results from two abnormalities that occur simultaneously: (a) insulin resistance of muscle and (b) an inadequate response (even when comparable to that of controls) of the beta-cells to appropriately secrete insulin to overcome the defect in insulin action. | 8119686 |
| Hyperglycemia, Impaired health, Cirrhotic, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus in insulin-resistant cirrhotic patients develops as the result of progressive impairment in insulin secretion together with the development of hepatic insulin resistance leading to fasting hyperglycemia and a diabetic glucose tolerance profile. | 8119686 |
| Glucose Intolerance (disease), Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. | 8119686 |
| Glucose Intolerance (disease), Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance and diabetes mellitus are both prevalent in cirrhosis, yet the pathogenesis of impaired glucose metabolism remains unknown. | 8119686 |
| Obesity | Deregulated Nutrient Sensing | Confluent and reticulated papillomatosis: a case with concurrent acanthosis nigricans associated with obesity and insulin resistance. | 8136544 |
| Dyslipidemias, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Several studies have indicated that insulin resistance, elevated blood pressure (BP), and dyslipidemia precede the onset of non-insulin-dependent diabetes mellitus (NIDDM). | 8138060 |
| Increased insulin level | Deregulated Nutrient Sensing | Several studies have shown that hyperinsulinemia and insulin resistance are associated with high triglyceride and low high-density lipoprotein (HDL) cholesterol levels. | 8148350 |
| Increased insulin level | Deregulated Nutrient Sensing | However, previous studies have been cross-sectional, and thus the presence of hyperinsulinemia or insulin resistance could be a consequence of the underlying lipid disorder instead of its cause. | 8148350 |
| TG gene, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The results suggest that in NIDDM (1) insulin sensitivity is determined mainly by percentage body fat and REE, (2) the insulin level determines the TG level directly, whereas the lipoproteins are influenced indirectly as a reflection of the degree of insulin resistance, and (3) insulin sensitivity is not related to blood pressure in a normotensive population. | 8159111 |
| Increased insulin level | Deregulated Nutrient Sensing | The sympathoadrenal system therefore, along with hyperinsulinemia, may contribute to the increased cardiovascular risk associated with the insulin resistance syndrome. | 8159112 |
| Dyslipidemias | Deregulated Nutrient Sensing | These data suggest that (1) epinephrine plays an important role in regulating lipid and lipoprotein metabolism in humans, and (2) decreased adrenal medullary activity may contribute to the dyslipidemia (increased triglycerides and decreased HDL-C) commonly observed among the obese. | 8159112 |
| thromboembolic, Diabetes Mellitus, Cerebrovascular accident, Hemorrhagic, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | This study was conducted to determine whether glucose intolerance and diabetes increase the risk of thromboembolic, hemorrhagic, and total stroke independent of other risk factors. | 8165689 |
| Obesity, Abdominal, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | In South Asians (Indians, Pakistanis, and Bangladeshis) settled overseas, high rates of coronary disease and non-insulin-dependent diabetes occur in association with central obesity and insulin resistance. | 8172093 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | It is concluded that acute mental stress induces a state of insulin resistance in IDDM patients, which can be demonstrated by an IGIT to appear 1 h after maximal stress and to last more than 5 h. | 8174837 |
| Amino Acid Metabolism, Inborn Errors | Deregulated Nutrient Sensing | Obesity-associated hyperaminoacidemia is traditionally interpreted as a consequence of insulin resistance. | 8177054 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | We performed two different experiments to investigate the effects of both obesity-associated insulin resistance and the insulin resistance of non-insulin-dependent diabetes mellitus (NIDDM) on amino acid metabolism. | 8177054 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | We were interested to know the extent of insulin resistance in a group of young, non-obese patients with hypertension. | 8185276 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and diabetes mellitus should be treated. | 8187462 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Markers on chromosome 4q have recently been shown to be associated with insulin resistance in Pima Indians, a population in which insulin resistance precedes and predicts the development of non-insulin-dependent diabetes mellitus (NIDDM). | 8194666 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | The U.K. NIDDM population was selected for insulin resistance by studying patients whose obesity-corrected fasting plasma insulin before treatment was above the 98th percentile. | 8194666 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Lewis phenotypes, insulin resistance, and risk of ischaemic heart disease. | 8198876 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Although mutations in the glucokinase gene are implicated in the pathogenesis of glucose intolerance in pedigrees with maturity-onset diabetes of the young, the role of such mutations in typical Type 2 diabetes is poorly characterized. | 8200207 |
| Stanford Cancer Institute | Deregulated Nutrient Sensing | SCI subjects had significantly higher mean glucose and insulin values at several points during the OGTT when compared with controls, suggesting an accentuated state of insulin resistance in those with SCI. | 8201966 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and glucose intolerance have been suggested to be involved in the pathogenesis of various cardiovascular diseases. | 8206582 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Role of glucose intolerance in cardiac diastolic function in essential hypertension. | 8206582 |
| Heart Diseases, Glucose Intolerance (disease), Neoplasms | Deregulated Nutrient Sensing | We would urge caution in the use of this form of therapy, particularly in older patients who may have occult neoplasms, impaired glucose intolerance or pre-existing cardiac disease. | 8208913 |
| Pancreatic carcinoma, Neoplasms, Diabetes Mellitus | Deregulated Nutrient Sensing | The diabetes mellitus that occurs in patients with pancreatic cancer is characterized by marked insulin resistance that declines after tumor resection. | 8277951 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Since IAPP may cause insulin resistance, its overproduction may contribute to the diabetes that occurs in these patients. | 8277951 |
| Glucose Intolerance (disease), Hypertriglyceridemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | The associates of gout-obesity, hypertriglyceridemia, glucose intolerance, and hypertension, strikingly resemble those of insulin resistance. | 8288709 |
| Hyperuricemia | Deregulated Nutrient Sensing | In the present study we determined whether hyperuricemia is associated with insulin resistance and, if so, whether this association can be explained by other components of the syndrome. | 8288709 |
| Angina Pectoris | Deregulated Nutrient Sensing | Insulin resistance, lipoproteins, body fat and hemostasis in nonobese men with angina and a normal or abnormal coronary angiogram. | 8294690 |
| Increased insulin level, Hypertension, CTCAE, Coronary heart disease, Congenital Abnormality | Deregulated Nutrient Sensing | Risk factors for coronary heart disease, including lipoprotein abnormalities, hypertension and adiposity, may be metabolically interlinked, with insulin resistance and hyperinsulinemia being pivotal to these disturbances. | 8294690 |
| Increased insulin level, Coronary heart disease | Deregulated Nutrient Sensing | These findings provide new evidence of the central role of insulin resistance and hyperinsulinemia in the development of risk factors associated with coronary heart disease. | 8294690 |
| Increased insulin level, Glucose Intolerance (disease), Hypertriglyceridemia | Deregulated Nutrient Sensing | In conclusion, LDL cholesterol metabolism improved in hypercholesterolemic subjects treated with pravastatin, but the hypertriglyceridemia, insulin resistance, relative glucose intolerance, and hyperinsulinemia present in patients with type IIB HLP either did not improve with treatment or was somewhat worse. | 8296701 |
| Hypertension, CTCAE, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance may be a mechanism linking non-insulin-dependent diabetes mellitus (NIDDM) to hypertension and cardiovascular mortality. | 8314023 |
| Hyperinsulinism, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and not hyperinsulinaemia determines erythrocyte Na+/Li+ countertransport in non-insulin-dependent diabetes mellitus. | 8523391 |
| Hypertension, CTCAE, Hyperinsulinism | Deregulated Nutrient Sensing | Insulin resistance and increased erythrocyte Na+/Li+ countertransport activity are well documented in subjects with essential hypertension, raising the question whether compensatory hyperinsulinaemia might be responsible for activating Na+/Li+ countertransport. | 8523391 |
| Hyperinsulinism | Deregulated Nutrient Sensing | It is concluded that increased Na+/Li+ countertransport may be a cellular marker for insulin resistance, but that hyperinsulinaemia is not likely to be the factor which mediates this relation. | 8523391 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These observations suggest that the homozygous Arg252-->His mutation is responsible for the type A insulin resistance of the proband, whereas in the heterozygous state, the mutation results in mild insulin resistance indistinguishable from that observed in noninsulin-dependent diabetes mellitus. | 8530617 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia is an important risk factor for atherosclerotic vascular disease. | 8534686 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To conclude, plasma TBARS were increased in impaired glucose tolerance and in diabetes and they were related to prevailing plasma glucose and insulin levels, suggesting a role for insulin resistance in increased lipid peroxidation process. | 8542741 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance increases during adolescence, and is exaggerated in patients with insulin dependent diabetes mellitus (IDDM). | 8548941 |
| Increased insulin level, Ischemic stroke | Deregulated Nutrient Sensing | Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke. | 8553400 |
| Increased insulin level, Ischemic stroke, Atherosclerosis | Deregulated Nutrient Sensing | Although insulin resistance and hyperinsulinemia play a crucial role in the pathogenesis of atherosclerosis, little is known about their roles in ischemic stroke. | 8553400 |
| Increased insulin level, Ischemic stroke | Deregulated Nutrient Sensing | The purpose of this study was to clarify whether insulin resistance and hyperinsulinemia are causative factors in the pathogenesis of ischemic stroke. | 8553400 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Steady state plasma glucose levels were significantly higher in the atherothrombotic infarction group compared with control subjects and the other two stroke groups, indicating the presence of insulin resistance in patients with atherothrombotic infarction. | 8553400 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Insulin resistance in association with compensatory hyperinsulinemia and dyslipidemia may be an important pathogenetic factor underlying the development of atherothrombotic infarction. | 8553400 |
| Neuropathy, Hyperglycemia, Dyslipidemias, GDC Comorbidity Terminology, Diabetes Mellitus, diabetic, Diabetes Mellitus, Insulin-Dependent, Hypoglycemia, CDISC SDTM Lesion Complexity Terminology, Obesity, Kidney Diseases, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | 1) On the basis of data from intervention trials in IDDM that prove that intensive glycemic control reduces microvascular and neuropathic complications, coupled with epidemiologic and basic scientific data that support the strong likelihood of a similar benefit in NIDDM, the goal of treatment in NIDDM should be near-normal glycemia (glycohemoglobin level no higher than 1.0% above the upper normal limit); 2) glycemic targets should be adjusted individually according to clinical factors such as increased risk for hypoglycemia, advanced age, or reduced life expectancy from comorbid conditions; 3) some degree of comprehensive and repetitive instruction about diet and exercise and the use of blood glucose self-monitoring for all patients is essential to achieve the chosen targets; 4) intensive management of hyperglycemia should be instituted early and should initially emphasize diet and exercise therapy; staged introduction of oral hypoglycemic agents and finally insulin regimens of increasing complexity are recommended as needed to achieve glycemic targets; 5) comprehensive care must also include aggressive attempts to reduce cardiovascular risk factors (particularly hypertension, smoking, dyslipidemia, and obesity) as well as prevention of nephropathy and neuropathy; 6) the complex interaction among treatment regimens for hyperglycemia, dyslipidemia, obesity, and hypertension ideally requires a team approach, using a physician, diabetes educator, nurse, dietitian, and other health professionals; health insurers should make these resources available to generalists who currently care for most diabetic patients. | 8554214 |
| Atherosclerosis, NEUROD1 wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Other areas of discussion centered on basic research, that is, the fundamental cause of insulin resistance and the genetics of NIDDM and the loss of protection against atherosclerosis in postmenopausal women with diabetes. | 8554215 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These coordinated actions indicate that physical training is able to influence the mechanisms of type 2 diabetes with insulin resistance when the etiology of type 1 diabetes is not influenced by physical training. | 8556419 |
| Traumatic | Deregulated Nutrient Sensing | Insulin resistance and autonomic function in traumatic lower limb amputees. | 8563461 |
| Kidney Diseases, Hypertrophy, Hyperlipoproteinemias | Deregulated Nutrient Sensing | ACE inhibitors and calcium antagonists are otherwise for diabetics drugs of first choice which can arrest the progression of nephropathy, effectively reduced the blood pressure without causing deterioration of insulin resistance and hyperlipoproteinaemia and lead even to regression of hypertrophy of the vascular wall and left ventricle. | 8578695 |
| Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Glycaemic control alone is often insufficient to control diabetic dyslipidaemia and other cardiovascular risk factors associated with NIDDM. | 8582541 |
| Retinal Diseases | Deregulated Nutrient Sensing | Indeed, in patients with inadequate metabolic control, the prevalence of retinopathy was significantly increased in those with higher endogenous insulin secretion (51.4 versus 20.6%, p < 0.02) and thus probably higher insulin resistance. | 8586152 |
| Dyslipidemias, Ascites, Hepatomegaly | Deregulated Nutrient Sensing | A regimen of dietary lipid restriction, gemfibrozil, and niacin resulted in significant but partial improvement of the dyslipidemia and resolution of the hepatomegaly and ascites. | 8589283 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, although patients with mitochondrial gene mutation had a high frequency of diabetes, the proportion of mutant DNA evaluated by blood samples may not necessarily indicate glucose intolerance in the members with the mutation. | 8591702 |
| Proteinuria, Dyslipidemias, diabetic, Diabetes Mellitus, Retinal Diseases, Hypertension, CTCAE, Non-compliance, Breast Fibrocystic Change, Non-Proliferative Type | Deregulated Nutrient Sensing | The factors analyzed were: diabetic (non-proliferative and proliferative) retinopathy, family histories of diabetes and hypertension, smoking, dyslipidemia, first examination proteinuria and non-compliance. | 8591710 |
| Microvascular Angina, diabetic | Deregulated Nutrient Sensing | Prevalence of macro- and microvascular diseases in non-insulin-dependent diabetic and borderline glucose-intolerant subjects with insulin resistance syndrome. | 8591713 |
| Microvascular Angina | Deregulated Nutrient Sensing | We conclude that the insulin resistance syndrome preferentially increases the development of CAD, and is also involved in the progression of microvascular diseases. | 8591713 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. | 8591825 |
| Glucose Intolerance (disease), Hyperinsulinism | Deregulated Nutrient Sensing | Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. | 8591825 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance in essential hypertensive patients with impaired glucose tolerance. | 8593759 |
| Increased insulin level, Hypertensive (finding), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These data show that in hypertensive patients without glucose intolerance insulin resistance might compensatorily augment second-phase insulin secretion and lead to hyperinsulinemia. | 8593759 |
| Increased insulin level, Glucose Intolerance (disease), Hyperglycemia, Postprandial, Antihypertensive Agents | Deregulated Nutrient Sensing | In hypertensives with glucose intolerance, insulin resistance might induce postprandial hyperglycemia, which leads to hyperinsulinemia because of second phase insulin secretion at a level similar to that of normotensives. | 8593759 |
| Hypertensive (finding), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The hypertensive patients without glucose intolerance showed a significantly lower insulin-mediated glucose disposal and a compensating increase in second-phase insulin secretion compared with normotensives without glucose intolerance. | 8593759 |
| Glucose Intolerance (disease), Antihypertensive Agents | Deregulated Nutrient Sensing | In hypertensives with glucose intolerance, insulin-mediated glucose disposal was significantly lower and second-phase insulin secretion was comparable to that in normotensives without glucose intolerance. | 8593759 |
| Glucose Intolerance (disease), Antihypertensive Agents | Deregulated Nutrient Sensing | After 3 months of angiotensin-converting enzyme (ACE) inhibition with oral administration of delapril, blood pressure was significantly reduced in the hypertensives with glucose intolerance (n = 9). | 8593759 |
| Hyperlipidemia, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Hyperlipidemia associated with non-insulin-dependent diabetes mellitus (NIDDM) and insulin resistance is characterized by high triglyceride levels; raised levels of total low-density lipoprotein (LDL), which is made up of small, dense, cholesterol-rich particles; low levels of high-density lipoprotein (HDL); and glycosylation of apolipoproteins. | 8595642 |
| Dyslipidemias | Deregulated Nutrient Sensing | A comparison of lovastatin, an HMG-CoA reductase inhibitor, with gemfibrozil, a fibrinic acid derivative, in the treatment of patients with diabetic dyslipidemia. | 8595642 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of clinically recognized hypertension and dyslipidemia increased 8.5-fold and 3.1- to 8.3-fold, respectively, in the overweight cohort versus the lean cohort (P < .05 to P < .0001). | 8596496 |
| Increased insulin level, Glucose Intolerance (disease), Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | This study presents evidence for a continuum form obesity to diabetes via glucose intolerance and hyperinsulinemic diabetes. | 8597498 |
| Non-insulin Hypoglycemic, Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | To establish whether the relation between size at birth and non-insulin dependent diabetes is mediated through impaired beta cell function or insulin resistance. | 8601111 |
| Obesity | Deregulated Nutrient Sensing | This relation seems to be mediated through insulin resistance rather than through impaired beta cell function and to depend on an interaction with obesity in adult life. | 8601111 |
| metabolic disturbance | Deregulated Nutrient Sensing | Metabolic disturbances, possibly related to insulin resistance, may provide a pathway through which fetal growth affects blood pressure. | 8601110 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance was observed only in the subjects with overt diabetes. | 8603770 |
| Massive Osteolyses, Glycogen Storage Disease, Dyslipidemias, Disease | Deregulated Nutrient Sensing | Liver glycogen storage diseases (GSD) are disorders associated with severe dyslipidaemia which can induce cell membrane alterations. | 8611649 |
| Cardiac complication, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | In addition to the typical dyslipidemia found in CAPD patients, high levels of Lp(a) and fibrinogen may contribute to the elevated risk of coronary artery disease and other cardiovascular complications. | 8616169 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Islet amyloid polypeptide is currently studied with regard to a role for insulin resistance in non-insulin-dependent diabetes. | 8616529 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | As adults, individuals with consistently elevated insulin versus those with consistently decreased insulin had increased (P<.05) prevalence of obesity (36-fold), hypertension (2.5-fold), and dyslipidemia (3-fold), which was attributed to both baseline insulin and change of insulin from baseline to follow-up. | 8616941 |
| Increased insulin level, Glucose Intolerance (disease), Cirrhotic | Deregulated Nutrient Sensing | In conclusion, these results suggest that hyperinsulinemia may be implicated in the glomerular hyperfiltration and sodium retaining tendency of preascitic cirrhotic patients with glucose intolerance. | 8617419 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of symptoms was often associated with the duration of diabetes and poor glycemic control as were complications, but complications were often also associated with dyslipidemias and an elevated mean arterial pressure. | 8620254 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Our results indicate that hyperinsulinemia is associated with high factor VII activity in a general Japanese population as well as with high blood pressure and dyslipidemia. | 8620342 |
| Cardiovascular Diseases, NEUROD1 wt Allele | Deregulated Nutrient Sensing | There is limited evidence that raised hematocrit levels may be associated with insulin resistance, which links cardiovascular disease with NIDDM. | 8621006 |
| Increased insulin level, Metabolic Diseases, Dyslipidemias, Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | Furthermore, our findings suggest that abnormalities in fibrinolytic function in older hypertensive men are likely due to the primary effects of other metabolic disorders that usually accompany hypertension, such as hyperinsulinemia and dyslipidemia. | 8621196 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Insulin resistance frequently accompanies endocrine-associated acanthosis nigricans. | 8621823 |
| Acanthosis Nigricans, Hyperandrogenism | Deregulated Nutrient Sensing | We describe a patient with acanthosis nigricans associated with hyperandrogenism and extreme insulin resistance that spontaneously resolved after a marked decrease in insulin receptor antibodies. | 8621823 |
| Weight Gain | Deregulated Nutrient Sensing | Relationship of insulin resistance to weight gain in nondiabetic Asian Indian, Creole, and Chinese Mauritians. | 8622608 |
| Obesity | Deregulated Nutrient Sensing | There is evidence from animal models that postprandial insulin hypersecretion may precede the development of obesity and insulin resistance, but it is not clear if this is the case in humans. | 8622608 |
| Weight Gain | Deregulated Nutrient Sensing | Recently, two longitudinal studies have suggested that insulin resistance acts to limit further weight gain rather than to promote it. | 8622608 |
| Weight Gain | Deregulated Nutrient Sensing | Insulin resistance predicted weight gain in Chinese men independently of baseline age and BMI. | 8622608 |
| Weight Gain | Deregulated Nutrient Sensing | These data provide suggestive but not convincing evidence that insulin resistance may limit weight gain, and contradictory evidence in one ethnic group that insulin resistance promotes weight gain. | 8622608 |
| Coronary Stenosis, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | No subjects had overt diabetes mellitus, hypertension, dyslipidemia, obesity or angiographically detected significant baseline coronary stenosis. | 8626958 |
| Hyperlipidemia, Muscle hypertrophy, Fatty Liver, Hyperglycemia, Hirsutism, Hepatomegaly, Acanthosis Nigricans | Deregulated Nutrient Sensing | The diagnosis is made on the basis of loss of body fat, muscular hypertrophy, acanthosis nigricans, hirsutism, hepatomegaly with fatty liver, hyperlipidemia and hyperglycemia with insulin resistance. | 8629139 |
| Obesity | Deregulated Nutrient Sensing | The authors conclude that, in addition to significant genetic influences on fasting insulin, environmental or behavioral factors (particularly nongenetic variation in obesity) are important determinants of fasting insulin and the insulin resistance syndrome. | 8633616 |
| Hypersensitivity | Deregulated Nutrient Sensing | There have been rare reports of allergic reactions to endogenously secreted insulin manifested as insulin resistance. | 8634879 |
| Hyperinsulinism | Deregulated Nutrient Sensing | However, this observation was not confirmed by other studies and is still a matter of controversy; furthermore, it is not known whether it represents a primary event or is secondary to hyperinsulinaemia and insulin resistance. | 8635675 |
| Hyperinsulinism, insulinoma | Deregulated Nutrient Sensing | In order to address this issue in patients with pure non-genetically determined hyperinsulinaemia, we examined the alternative splicing of insulin receptor mRNAs in skeletal muscle of eight patients with surgically confirmed insulinoma and insulin resistance and in eight healthy subjects, using the reverse transcriptase-polymerase chain reaction technique. | 8635675 |
| Ataxia Telangiectasia, Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that insulin resistance and islet beta-cell dysfunction are characteristics of diabetes mellitus in ataxia-telangiectasia. | 8638204 |
| Dyslipidemias, Infection, Cataract, Polyuria, Diabetic Retinopathy, Kidney Diseases, Nocturia | Deregulated Nutrient Sensing | When their sugars are controlled, older diabetics will have less nocturia and polyuria; fewer infections; better wound healing; a decrease in the rate of progression of cataracts, diabetic retinopathy, and nerve and renal disease; and better control of dyslipidemia. | 8641590 |
| Glucose Intolerance (disease), Jaundice, Obstructive | Deregulated Nutrient Sensing | Glucose intolerance and impaired insulin secretion are often associated with obstructive jaundice. | 8644011 |
| Glucose Intolerance (disease), Cushing Syndrome | Deregulated Nutrient Sensing | Factors influencing the development of glucose intolerance in Cushing syndrome. | 8651039 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Adverse levels of LDL-C in childhood persist over time, progress to adult dyslipidemia, and relate to obesity and hypertension as well. | 8651840 |
| Mortality, Premature, Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Health risks also increase with excess abdominal/visceral fat (as estimated by a waist-hip ratio [WHR] > 1.0 for males and > 0.8 for females), high blood pressure (> 140/90), dyslipidemias (total cholesterol and triglyceride concentrations of > 200 and > 225 mg/dl, respectively), non-insulin-dependent diabetes mellitus, and a family history of premature death due to cardiovascular disease (e.g., parent, grandparent, sibling, uncle, or aunt dying before age 50). | 8653537 |
| Thrombosis | Deregulated Nutrient Sensing | A possible cause of accelerated atherothrombosis in the syndrome of insulin resistance appears to be an elevated blood concentration of plasminogen activator inhibitor type-1 (PAI-1). | 8669417 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | When to treat dyslipidaemia of patients with chronic renal failure on haemodialysis? | 8671784 |
| Cancer-related fatigue, Dyslipidemias, Chronic Kidney Diseases, Atherosclerosis | Deregulated Nutrient Sensing | There are no specific recommendations for management of dyslipidaemia in patients with chronic renal failure (CRF) on haemodialysis, in which atherosclerosis is a common cause of morbidity and mortality. | 8671784 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | These results clearly demonstrated that duration of diabetes, smoking, hypertension, and dyslipidemia are major risk factors for MA in NIDDM patients. | 8674883 |
| Hypertension, CTCAE, Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, in nonobese NIDDM patients, age, hypertension, and dyslipidemia were found to be risk factors for MA. | 8674883 |
| Injury of kidney | Deregulated Nutrient Sensing | Insulin resistance, elevated glomerular filtration fraction, and renal injury. | 8675252 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The development of insulin resistance may be an early step in the development of hypertension; however, the mechanism for this process is not known. | 8675252 |
| Hypertension, CTCAE, Injury of kidney | Deregulated Nutrient Sensing | The worsening of insulin resistance and hypertension could increase both systemic and glomerular capillary pressures and predispose an individual to renal injury. | 8675252 |
| Hypertensive (finding), Injury of kidney | Deregulated Nutrient Sensing | This suggests that a greater degree of insulin resistance, not increased dietary salt, may predispose older mildly hypertensive subjects to renal injury by worsening renal hemodynamics through the elevation of glomerular filtration fraction and resultant glomerular hyperfiltration. | 8675252 |
| Atherosclerosis | Deregulated Nutrient Sensing | The insulin resistance atherosclerosis study (IRAS) objectives, design, and recruitment results. | 8680609 |
| Increased insulin level | Deregulated Nutrient Sensing | Forthcoming cross-sectional analyses will help to disentangle the association between insulin resistance and CVD, apart from the concomitant hyperinsulinemia and related CVD risk factors. | 8680609 |
| Dyslipidemias | Deregulated Nutrient Sensing | A high frequency of dyslipidemia was found among UDDM group in our study. | 8683643 |
| Tuberculosis, Pulmonary, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The frequency of glucose intolerance was studied in 106 patients with pulmonary tuberculosis attending Nazimabad Chest Clinic. | 8683828 |
| Glucose Intolerance (disease), Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance was detected in 52 (49%) patients, 31 Impaired Glucose Tolerance (IGT), 21 Diabetes Mellitus (DM). | 8683828 |
| Dyslipidemias, Hyperinsulinism | Deregulated Nutrient Sensing | Dyslipidaemia and hyperinsulinaemia have been proposed as aetiological factors. | 8689846 |
| Impaired T cell function, NEUROD1 wt Allele | Deregulated Nutrient Sensing | This suggests that beta cell dysfunction, rather than increased insulin resistance, is responsible for the development of NIDDM. | 8689855 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance and impaired insulin secretion are thought to be the primary defects in the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). | 8690169 |
| TG gene, Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Frequency of dyslipidemia in the studied sample was 24.4% for high TG, 23.6% for low HDL-C, 23.6% for high LDL-C, 14.9% for Lp(a) excess (Lp(a) > or = 30 mg/dl; overweight and obesity were more prevalent among women. | 8696067 |
| Graves Disease, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Untreated Graves' disease was associated with glucose intolerance due to quantitative as well as qualitative beta-cell defects. | 8706294 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Demonstration of insulin resistance in coronary artery disease documented with angiography. | 8720524 |
| Coronary Artery Disease, Atherosclerosis | Deregulated Nutrient Sensing | To evaluate the relation between insulin resistance and coronary atherosclerosis, insulin sensitivity in lean nondiabetic, normotensive subjects with and without obstructive coronary artery disease (CAD). | 8720524 |
| Coronary Stenosis | Deregulated Nutrient Sensing | The correlation between insulin resistance and degree of coronary stenosis was also investigated. | 8720524 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Hyperinsulinemia in the presence of insulin resistance aggravates dyslipidemia and may stimulate the atheromatous process by an as-yet-unknown mechanism. | 8720524 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Increased proinsulin and proinsulin-to-insulin molar ratio in elderly, but not in obese, subjects without glucose intolerance. | 8720525 |
| Amyloidosis, NEUROD1 wt Allele | Deregulated Nutrient Sensing | However, the question remains whether chronic overstimulation of insulin and islet amyloid polypeptide (IAPP) secretion in states of insulin resistance could lead to formation of islet amyloidosis and hence NIDDM in some patients. | 8720529 |
| Familial generalized lipodystrophy | Deregulated Nutrient Sensing | We studied pancreatic islet pathology in congenital generalized lipodystrophy, a genetic syndrome of extreme insulin resistance that may provide some clues. | 8720529 |
| Amyloidosis | Deregulated Nutrient Sensing | These observations suggest that chronic presence of extreme insulin resistance may induce premature and severe islet amyloidosis as well as beta-cell atrophy. | 8720529 |
| Hyperproinsulinemia, Increased insulin level | Deregulated Nutrient Sensing | These results indicate that when specific assays for insulin are used, Asian subjects show postglucose load hyperinsulinemia and fasting hyperproinsulinemia compared with white subjects, suggesting increased insulin secretion and/or the presence of underlying insulin resistance in this ethnic group. | 8720531 |
| Beta-cell dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest that beta-cell dysfunction rather than insulin resistance plays the most important role in the future development of diabetes in a high-risk Caucasian population. | 8720611 |
| Hyperglycemia | Deregulated Nutrient Sensing | Laboratory examination showed hyperglycemia, increased glycosilated hemoglobin (HbA1c) and insulin resistance on euglycemic glucose clamp. | 8723046 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our data indicates that this mutation may be a relatively common cause of dyslipidemia in the Spanish population. | 8724110 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Whereas insulin resistance was higher in patients with hypertension, the increase in insulin resistance with age was much more apparent in normotensive patients, resulting in similar insulin levels at high ages. | 8728302 |
| Increased insulin level | Deregulated Nutrient Sensing | The results of this study show that hyperinsulinemia is associated with raised blood pressure in elderly people, and suggest that the age-associated increase in insulin resistance is diminished in patients with raised blood pressure. | 8728302 |
| hydroxyurea, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia occurred with the highest prevalence (p = 0.36), the highest positive predictive value (v = 0.44) and, together with HU and diabetes, the highest nosologic specificity (f = 0.55 in both cases). | 8730125 |
| Dyslipidemias | Deregulated Nutrient Sensing | His brother also had typical features of CTX without the presence of dyslipidaemia. | 8730343 |
| Obesity | Deregulated Nutrient Sensing | There was an increase of proinsulin related to obesity and increased glucose levels, suggesting that proinsulin levels increase with insulin resistance. | 8731348 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | It is suggested that insulin resistance was associated with sodium sensitivity, and they might play a role in the development of hypertension in childhood. | 8731845 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, dyslipidemia appears to manifest only if VLDL production is also increased. | 8732773 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Hyperinsulinemia was the major determinant of excessive VLDL synthesis and dyslipidemia among the subjects heterozygous for the A291S mutation in this study. | 8732773 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Impaired fibrinolysis and insulin resistance in patients with hypertension. | 8735180 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with hypertension were further subdivided into two groups: insulin resistance (SSPG > 190 mg/dL, n = 14) and no insulin resistance (SSPG < 190 mg/dL, n = 14). | 8735180 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | As compared to normal controls, hypertensive patients, either with or without insulin resistance, had a significant (P < .005) increases in PAI-1 activity (18.6 +/- 1.3 upsilon 8.1 +/- 0.8 IU/mL), PAI-1 antigen (31.1 +/- 2.0 upsilon 12.7 +/- 0.9 ng/mL) and tPA antigen (15.5 +/- 0.9 upsilon 8.8 +/- 0.9 ng/mL), and significant decrease in tPA activity (0.43 +/- 0.05 upsilon 1.02 +/- 0.16 IU/mL) than normotensive controls. | 8735180 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Furthermore, hypertensive patients with insulin resistance had significantly higher PAI-1 activity (22.0 +/- 2.2 upsilon 15.3 +/- 0.8 IU/mL, P = .006) and tPA antigen (17.4 +/- 1.2 upsilon 13.6 +/- 1.3 ng/mL, P = .02) than did hypertensive patients without insulin resistance. | 8735180 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | However, PAI-1 antigen was insignificantly higher (34.1 +/- 2.9 upsilon 28.1 +/- 2.4 ng/mL, P = .06) and tPA activity insignificantly lower (0.42 +/- 0.08 upsilon 0.43 +/- 0.08 IU/mL, P = .47) in hypertensive patients with insulin resistance than in those without insulin resistance. | 8735180 |
| Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | Thus, patients with hypertension have impaired fibrinolytic activity due to increased PAI-1 when compared to normotensive controls, and the magnitude of this fibrinolytic defect is greater in hypertensive patients who have insulin resistance. | 8735180 |
| No metabolic abnormalities, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance with associated metabolic abnormalities may be one of the causes for impaired fibrinolysis in hypertension. | 8735180 |
| Gestational Diabetes, Exceptionally large baby (disorder), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In patients with GDM the degree of glucose intolerance (determined by FBG on the GTT) and maternal weight were the only variables that significantly increased the risk of macrosomia and operative delivery. | 8735291 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia in patients with chronic renal failure and in renal transplant patients. | 8737552 |
| Glucose Intolerance (disease), Diabetes Mellitus, NEUROD1 wt Allele, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | The findings suggest that in this age group in a Caucasian population, not only does insulin resistance precede glucose intolerance and NIDDM, but also loss of early insulin response indicating impaired beta-cell function to be an early feature of the process culminating in diabetes. | 8739917 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance and impaired insulin secretion can be involved in the development of non-insulin-dependent diabetes mellitus (NIDDM), but their relative importance or temporal relationship are poorly understood. | 8745206 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | We conclude that the increased insulin secretion compensates for the peripheral insulin resistance of subjects with slightly deteriorated glucose tolerance, implying that insulin resistance plays an important role in the pathogenesis of NIDDM in some fraction of Japanese population. | 8745206 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | To elucidate this issue, we studied 51 subjects with borderline glucose intolerance (BGI) and 18 normal glucose tolerant subjects (NGT) according to the Japan Diabetes Society criteria. | 8745206 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia have been linked with essential hypertension. | 8747309 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Age-associated increases in glucose intolerance and hypertension are also well established. | 8747309 |
| Senile cataract, Dyslipidemias | Deregulated Nutrient Sensing | Some persons with treatable disorders such as senile cataract and dyslipidaemia were also detected by the screening programme. | 8758055 |
| Increased insulin level, Hypertensive (finding) | Deregulated Nutrient Sensing | Hypertensive patients frequently show resistance to insulin-stimulated glucose uptake and hyperinsulinemia. | 8761899 |
| Hypertensive (finding), Overweight, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | People with the following attributes: female, overweight, hypertensive and with glucose intolerance were those with more concern about health and prevention. | 8762691 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Intracellular fat may underlie a major part of the insulin resistance in normal subjects, as well as type II diabetics. | 8769349 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lack of a relationship between urinary albumin excretion rate and insulin resistance in patients with non-insulin-dependent diabetes mellitus. | 8781291 |
| Microalbuminuria, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Thus, resistance to insulin-mediated glucose disposal occurs in patients with NIDDM in the absence of microalbuminuria, and we could not detect any relationship between UAE and insulin resistance in this population. | 8781291 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The study was performed to determine the relationship between urinary albumin excretion (UAE) and resistance to insulin-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM). | 8781291 |
| Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Non-insulin dependent diabetes mellitus (NIDDM) affects more than 100 million people worldwide and is associated with severe metabolic defects, including peripheral insulin resistance, elevated hepatic glucose production, and inappropriate insulin secretion. | 8782826 |
| Glucose Intolerance (disease), Paresis | Deregulated Nutrient Sensing | Affected individuals also have proximal muscle weakness, facial involvement, nonspecific abnormalities on muscle biopsy, normal cardiac conduction, and no glucose intolerance. | 8784800 |
| Uremia, Dyslipidemias, Diabetic Angiopathies | Deregulated Nutrient Sensing | Dyslipidemia possibly contributes to the vascular complications commonly afflicting uremic patients. | 8785232 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Therefore, mutations in the HK2 gene could contribute to skeletal muscle insulin resistance in NIDDM. | 8786021 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | The data thus seem to rule out mutations in the HK2 gene as a major cause of inherited insulin resistance in NIDDM. | 8786021 |
| Microvascular Angina, Hyperlipoproteinemias | Deregulated Nutrient Sensing | Insulin resistance and hyperlipoproteinemia in microvascular angina: risk factors or pathogenetic link? | 8789672 |
| Hyperlipoproteinemias, Microvascular Angina, Hypertensive heart disease | Deregulated Nutrient Sensing | The metabolic profile in patients with microvascular angina suggests a pathogenetic role of insulin resistance and hyperlipoproteinemia in the setting of impaired myocardial coronary reserve and in early stages of hypertensive heart disease. | 8789672 |
| Increased insulin level | Deregulated Nutrient Sensing | Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. | 8790020 |
| Increased insulin level | Deregulated Nutrient Sensing | Long-term use of nicotine-containing chewing gum was associated with insulin resistance and hyperinsulinemia. | 8790020 |
| Cardiovascular morbidity, No metabolic abnormalities | Deregulated Nutrient Sensing | These findings suggest that nicotine is the major constituent in cigarette smoke that leads to insulin resistance, metabolic abnormalities associated with the insulin resistance syndrome, and increased cardiovascular morbidity. | 8790020 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | High glycosylated hemoglobin levels increase the risk of progression to diabetes mellitus in subjects with glucose intolerance. | 8792104 |
| Glucose Intolerance (disease), NEUROD1 wt Allele | Deregulated Nutrient Sensing | The results showed that the combination of HbA1c level and OGTT enables more precise prediction of progression to NIDDM in subjects with glucose intolerance. | 8792104 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | High prevalence of dyslipidaemia despite adequate glycaemic control in patients with diabetes. | 8799011 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We suggest that an active strategy of early detection and drug treatment for dyslipidaemia is needed for patients with diabetes mellitus. | 8799011 |
| Diabetes Mellitus, Insulin-Dependent, Hypoglycemia | Deregulated Nutrient Sensing | Insulin-dependent diabetic women may rarely develop exaggerated insulin sensitivity in the first trimester of pregnancy resulting in severe hypoglycaemia, but spontaneous improvement occurs with increasing insulin resistance in the second and third trimesters. | 8799666 |
| Hyperglycemia | Deregulated Nutrient Sensing | Alimentary hyperglycemia in patients with subtotal gastrectomy is associated with decreased insulin secretion but not with insulin resistance. | 8803702 |
| Hyperglycemia | Deregulated Nutrient Sensing | These results suggest that in patients with alimentary hyperglycemia, glucose tolerance was impaired due to a decreased pancreatic sensitivity to blood glucose and not due to insulin resistance. | 8803702 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Patients were categorized into three groups by OGTT; 8 cases were in group I (normal), 19 cases in group II (alimentary hyperglycemia), and 9 cases in group III (glucose intolerance). | 8803702 |
| diabetic, Insulin resistance syndrome | Deregulated Nutrient Sensing | The population is characterized by a large percentage of elderly patients, diabetic patients, and patients with the clinical characteristics of the insulin-resistance syndrome. | 8806347 |
| Glucose Intolerance (disease), Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | This suggests that RT has the potential to ameliorate and perhaps prevent the development of insulin resistance and may reduce the risk for glucose intolerance and non-insulin-dependent diabetes mellitus (NIDDM) in postmenopausal women. | 8808989 |
| Electrocardiogram abnormal, Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | Electrocardiographic abnormalities and other cardiovascular risk factors were common among these hypertensives, with dyslipidaemia, past or current smoking and lack of physical exercise being present in the majority of those studied. | 8809371 |
| Non-insulin Hypoglycemic, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance characterizes non-insulin dependent diabetes (NIDDM). | 8813436 |
| Hyperestrogenism, Hyperandrogenism | Deregulated Nutrient Sensing | Insulin resistance may coexist in clinical syndromes with hyperestrogenism and hyperandrogenism, suggesting that the ovary may be sensitive to effects of insulin. | 8813436 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Elevated plasma cholesteryl ester transfer protein (CETP) mass is characteristic of combined hyperlipidaemia (CHL), an atherogenic dyslipidaemia characterized by increased levels of both very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) and subnormal levels of high-density lipoprotein (HDL). | 8817163 |
| Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore, pharmacological intervention should aim to improve insulin sensitivity. | 8817248 |
| Uremia | Deregulated Nutrient Sensing | Abnormal glucose metabolism in uremia may result from a complex interplay between decreased insulin secretion and insulin resistance. | 8820510 |
| Schistosomiasis, Glucose Intolerance (disease), Pancreatic Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | glucose load in children with schistosomiasis suggest that auto-immune aggression against the islet cells contributes in the pathogenesis of pancreatic disease in these patients, and might increase the risk for developing glucose intolerance and diabetes. | 8820621 |
| Microalbuminuria, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Higher prevalence rates of micro- and macroalbuminuria were also found among Arizona participants than participants with similar degrees of glucose intolerance from the other two sites. | 8821844 |
| Glucose Intolerance (disease), Acromegaly | Deregulated Nutrient Sensing | These results indicate that octreotide improves insulin resistance at the insulin receptor site by lowering plasma levels of GH and insulin in acromegalic patients with glucose intolerance. | 8822314 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Before octreotide therapy, 2 patients had normal responses of plasma glucose and insulin to 75-g OGTT (normal glucose tolerance: NGT) and 4 showed hyperinsulinemia or glucose intolerance (glucose intolerance: GIT). | 8822314 |
| Increased insulin level, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are associated with multiple abnormalities of lipoprotein subclasses in glucose-tolerant relatives of NIDDM patients. | 8827527 |
| Depression, CTCAE, Overweight | Deregulated Nutrient Sensing | We concluded that: (1) data indicative of insulin resistance correlated to both depression and sleep alterations; (2) overweight is related to NSSD, sleep alterations, and hormonal changes. | 8834092 |
| Chronic disease, Obesity | Deregulated Nutrient Sensing | The differential effect of obesity on glucose, blood pressure, and lipid levels in the Inuit compared with non-Inuit suggests a type of selective insulin resistance, the underlying mechanism of obesity and several chronic diseases. | 8838915 |
| Dyslipidemias, Sialorrhea, Abdominal Pain | Deregulated Nutrient Sensing | Dyslipidaemia in a boy with recurrent abdominal pain, hypersalivation and decreased lipoprotein lipase activity. | 8839720 |
| Acanthosis Nigricans, Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Absence of acanthosis nigricans in a patient with the type B syndrome of insulin resistance and preexisting diabetes. | 8842610 |
| cell wall thickening | Deregulated Nutrient Sensing | Insulin resistance as an independent risk factor for carotid wall thickening. | 8843883 |
| Hypertension, CTCAE, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | In conclusion, insulin resistance was the strongest risk factor for carotid intima-media thickness, followed by lower high-density lipoprotein cholesterol and hypertension. | 8843883 |
| Congenital Abnormality | Deregulated Nutrient Sensing | These results suggest that in salt-sensitive essential hypertensives increased pressor responses to angiotensin and norepinephrine and elevation of BP as well as insulin resistance may result from inherited abnormalities of intracellular calcium metabolism. | 8846505 |
| Atherosclerosis | Deregulated Nutrient Sensing | Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance. | 8857823 |
| Atherosclerosis | Deregulated Nutrient Sensing | The authors also evaluated the association of insulin resistance with atherosclerosis in a cross-sectional setting. | 8857823 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The association of the G-A mutation at np 3316 with glucose intolerance suggests the importance of this area for the development of diabetes. | 8858117 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance in non-obese hypertensive subjects--its role in free fatty acid metabolism. | 8858377 |
| Hypertension, CTCAE, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Non insulin dependent diabetes mellitus (NIDDM) and essential hypertension (EH) are two of several manifestations of the insulin resistance syndrome. | 8860097 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Levels of von Willebrand factor, insulin resistance syndrome, and a common vWF gene polymorphism in non-insulin-dependent (type 2) diabetes mellitus. | 8862946 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To examine the association between von Willebrand Factor (vWF) concentrations and features of the insulin resistance syndrome, 208 patients with Type 2 (non-insulin-dependent) diabetes (NIDDM) and 80 healthy controls were studied. | 8862946 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, these findings show vWF concentrations are elevated in NIDDM and are weakly related to features of the insulin resistance syndrome. | 8862946 |
| Hypertension, Renovascular | Deregulated Nutrient Sensing | In conclusion, renovascular hypertension is not associated with insulin resistance. | 8864417 |
| Glucose Intolerance (disease), Liver carcinoma, Liver Cirrhosis | Deregulated Nutrient Sensing | [Glucose intolerance after percutaneous ethanol injection therapy (PEI) in liver cirrhosis patients with hepatocellular carcinoma]. | 8865748 |
| Uremia | Deregulated Nutrient Sensing | It could be explained, at least in part, by the insulin resistance present in uremia. | 8865877 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Despite controlling for physician selection, we demonstrated increased rates of abdominal delivery, glucose intolerance, and hypertension in older patients. | 8866293 |
| Hypogonadism | Deregulated Nutrient Sensing | It has been suggested that a relative hypogonadism might be a primary event, because other studies have shown that testosterone deficiency is followed by insulin resistance, which is ameliorated by testosterone substitution. | 8866567 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | To establish the prevalence of insulin resistance in hypertensive subjects. | 8866908 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | A similar prevalence of insulin resistance in hypertensive patients was found (31%) if the 95th percentile of the non-normally distributed insulin sensitivity index (M/I at clamp) was used to define the cutoff limit for insulin resistance: (4.4 mg/kg per min)/(mU/l x 100). | 8866908 |
| Non-insulin Hypoglycemic, Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance in hypertension was also associated with an increased heart rate (+3 beats/min faster than in non-insulin resistant hypertensive patients, P < 0.01), but no significant differences in blood pressure were found between insulin resistant and non-insulin resistant hypertensive patients. | 8866908 |
| Hyperglycemia, Hypertensive (finding), Diabetes Mellitus | Deregulated Nutrient Sensing | When insulin resistance was defined as an M-value at clamp of < 4.4 mg/kg per min, based on calculations from a healthy control sample, about 25% of a sample of hypertensive subjects, taking no antihypertensive treatment and with no history of diabetes mellitus or hyperglycaemia, was found to be insulin resistant. | 8866908 |
| Lipolysis | Deregulated Nutrient Sensing | Thus, insulin resistance in ageing appears selective on glucose utilization, inhibition of lipolysis and feedback inhibition of the B-cell secretion. | 8872059 |
| teratologic, NEUROD1 wt Allele, Cardiovascular Diseases | Deregulated Nutrient Sensing | The constellation of anomalies associated with insulin resistance is a plausible additional cause of ischemic cardiovascular disease and of NIDDM. | 8875083 |
| TG gene, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | In both groups, glucose intolerance was associated with increasing age, higher BMI, WHR, BP, Ualb, serum TG, and insulin levels as well as higher prevalence rates of positive family history of diabetes. | 8875088 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | A prediction model for estimating insulin resistance in hypertensive patients is presented. | 8879599 |
| Hypertension, CTCAE, Coronary heart disease | Deregulated Nutrient Sensing | These findings suggest that risk to coronary heart disease and hypertension through insulin resistance already operates in school-aged children. | 8886342 |
| Weight Gain, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Poor pregnancy weight gain was associated with the late development of glucose intolerance (P < .001). | 8887193 |
| Obesity | Deregulated Nutrient Sensing | Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. | 8892415 |
| Hyperinsulinism | Deregulated Nutrient Sensing | The relation with insulin independent of body mass index suggests a possible role for leptin in insulin resistance or hyperinsulinaemia. | 8892415 |
| Hyperinsulinism, NEUROD1 wt Allele | Deregulated Nutrient Sensing | This data suggests that insulin resistance, or hyperinsulinaemia, does not play a major role in the development of NIDDM in Korea. | 8894474 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Taken together with the rarity of obese NIDDM in Korea, it maybe suggested that the insulin secretory capacity of Korean people being smaller than Western people they cannot compensate for the insulin resistance imposed by recent changes in life style. | 8894474 |
| Cell secretion, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance and secretory defects seem to be present in Swedish obese elderly, NIDDM subjects. | 8894488 |
| Hyperinsulinism, NEUROD1 wt Allele | Deregulated Nutrient Sensing | In the Japanese-Americans, diminished early insulin release to an oral glucose challenge and increased insulin resistance characterized by hyperinsulinaemia are suspected to be some of the important risk factors for NIDDM. | 8894497 |
| Hyperglycemia, Dyslipidemias, NEUROD1 wt Allele, Cardiovascular Diseases | Deregulated Nutrient Sensing | Although classic cardiovascular risk factors are operative in subjects with NIDDM, other factors closely related to insulin resistance syndrome such as diabetic dyslipidemia and hyperglycemia itself may contribute to an excessive cardiovascular disease risk in subjects with NIDDM. | 8898803 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | The main determinants of IMT in NIDDM patients were related to both postglucose insulin levels and abnormal lipoprotein profiles characteristic of NIDDM and insulin resistance syndrome. | 8898803 |
| Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore, pharmacological intervention should aim to improve insulin sensitivity. | 8901147 |
| Hyperlipidemia, Apolipoprotein E | Deregulated Nutrient Sensing | Effect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients. | 8902145 |
| Obesity | Deregulated Nutrient Sensing | Recent studies have suggested that a missense Trp64Arg mutation in the beta3 adrenergic receptor (ADRB3) gene was involved in obesity and insulin resistance. | 8903328 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Insulin resistance was related to obesity, but not to a family history of hypertension, as had previously been reported by other research groups. | 8906517 |
| Hypercholesterolemia, Glucose Intolerance (disease), Hypertriglyceridemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of hypercholesterolemia, hypertriglyceridemia, hypertension, and overweight rose with increasing degrees of glucose intolerance. | 8908393 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Efforts to prevented diabetes should be focused on ways to reduce insulin resistance and obesity. | 8922541 |
| Hyperuricemia | Deregulated Nutrient Sensing | These data indicate that, already in young, essentially health subjects, hyperuricaemia associates with several components of the so-called insulin resistance syndrome, thus suggesting that increased levels of uric acid might be another member of this syndrome. | 8923153 |
| Hyperuricemia, Obesity | Deregulated Nutrient Sensing | In addition, these data suggest that obesity and central body fat distribution, rather than hyperinsulinaemia/insulin resistance, play a major role in linking hyperuricaemia with CVD risk factors clustering in the insulin resistance syndrome. | 8923153 |
| Osteogenesis, Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | From this study, obesity was shown to be the major risk factor of ossification of the nucal ligament, and obesity and glucose intolerance were risk factors in ossification of the anterior longitudinal ligament and ossification of the posterior longitudinal ligament. | 8923634 |
| Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Food additive eikonol is recommended for wide administration in elderly NIDDM patients with atherogenic dyslipidemias. | 8926697 |
| Cerebrovascular Disorders, Dyslipidemias, Coronary Artery Disease, Cerebrovascular accident | Deregulated Nutrient Sensing | Although dyslipidemia is a well established risk factor for coronary artery disease, its relationship to ischemic cerebrovascular disease has remained unclear, perhaps because of the heterogeneous nature of strokes. | 8929151 |
| Increased insulin level, Sick Sinus Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Association of sick sinus syndrome with hyperinsulinemia and insulin resistance in patients with non-insulin-dependent diabetes mellitus: report of four cases. | 8929644 |
| Increased insulin level, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Because insulin is a physiological regulator of cell-membrane Na+/K+-ATPase, we speculate that malfunction of the sinus node automaticity may be caused by chronic exposure to hyperinsulinemia secondary to insulin resistance in these NIDDM patients. | 8929644 |
| Muscle Cramp | Deregulated Nutrient Sensing | Thus, partial PGAM deficiency, insulin resistance and mild diabetic sensory-motor polyneuropathy can induce severe cramps. | 8933190 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It is also applied to dyslipidemia in patients with diabetes mellitus. | 8935222 |
| Generalized amyotrophy | Deregulated Nutrient Sensing | insulin resistance or skeletal muscle wasting, may be suggested by the present data. | 8938547 |
| Beta-cell dysfunction, NEUROD1 wt Allele | Deregulated Nutrient Sensing | We conclude that both beta-cell dysfunction and insulin resistance are present in first-degree relatives of NIDDM. | 8946153 |
| Glucose Intolerance (disease), Beta-cell dysfunction | Deregulated Nutrient Sensing | The progression of beta-cell dysfunction and glucose intolerance with age suggests that beta-cell dysfunction is the key factor in the apparition and progression of the disease. | 8946153 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We conclude that glucose intolerance is associated with impaired peripheral large-fibre nerve function, an association which seems to apply even in the non-diabetic range. | 8946154 |
| NEUROD1 wt Allele, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, diabetic | Deregulated Nutrient Sensing | Obesity and insulin resistance are important risk factors for the development of noninsulin-dependent diabetes (NIDDM) and are prevalent among predisposed first degree relatives of diabetic individuals. | 8954053 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Recent molecular screening and analysis of a common missense mutation of the beta 3-adrenergic receptor gene suggested this locus as a strong candidate for increased obesity, earlier age of diabetes onset, and insulin resistance. | 8954053 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | We conclude that the beta 3-adrenergic receptor locus does not play an important role in NIDDM susceptibility or in the insulin resistance syndrome among members of families with a strong predisposition to NIDDM. | 8954053 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | These results show that Papua New Guineans are by no means protected from dyslipidemia and serve warning that, unless effective preventative strategies can be developed, this and similar rapidly developing populations can expect an increasing incidence of coronary heart disease. | 8956625 |
| insulinoma, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We conclude that insulin resistance was caused by postreceptor changes in obese Type 2 diabetes, whereas a decreased insulin binding capacity together with post-receptor defect was present in insulinoma patients. | 8960900 |
| Fatty degeneration | Deregulated Nutrient Sensing | Increased steatosis of the liver is associated with reduced insulin clearance, contributing to insulin resistance in non-diabetic Japanese men and women. | 8963349 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The Trp64-->Arg allele of the beta 3-adrenergic receptor gene was recently proposed to be associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), features of insulin resistance and a tendency to gain weight. | 8968849 |
| Increased insulin level, Diabetes Mellitus, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Obesity is a common component of non-insulin-dependent diabetes mellitus (NIDDM) and plays an important role in the development of insulin resistance and hyperinsulinemia. | 8969285 |
| Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | It has been assumed that the etiology for this increased rate of NIDDM is related to the morbid obesity and concomitant insulin resistance, but this remains controversial. | 8969285 |
| Health Information Exchange, Obesity | Deregulated Nutrient Sensing | In summary, this study demonstrates that nondiabetic PWS subjects manifest (1) a reduced beta-cell response to glucose stimulation, (2) a significantly increased HIE compared with obese controls, and (3) a dissociation of obesity and insulin resistance, in contrast to normal obese subjects. | 8969285 |
| Increased insulin level, Obesity, Abdominal, Hyperglycemia, Dyslipidemias, Hostility, Hypertension, CTCAE, Fatigue | Deregulated Nutrient Sensing | In 90 middle-aged male volunteers, psychosocial stress-related variables, defined as feelings of excessive tiredness and as personality and behavioral factors reflecting a stress-inducing life-style (type A behavior, hostility, and anger), were significantly correlated with the hyperinsulinemia, hyperglycemia, dyslipidemia, hypertension, increased abdominal obesity, and increased plasminogen activator inhibitor-1 (PAI-1) antigen comprising the IRS. | 8969288 |
| Obesity, Abdominal, Hostility, Dyslipidemias, Fatigue | Deregulated Nutrient Sensing | Hostility was related to elevated systolic blood pressure (SBP) and elevated triglycerides (TGs) (canonical r = .38, chi2(14) = 23.2, P = .052), whereas feelings of excessive tiredness were related to abdominal obesity, augmented glycemic responses to glucose ingestion, dyslipidemia, and increased PAI-1 antigen (canonical r = .39, chi2(24) = 36.8, P = .046). | 8969288 |
| Increased insulin level | Deregulated Nutrient Sensing | Cigarette smoking is not associated with hyperinsulinemia: evidence against a causal relationship between smoking and insulin resistance. | 8969291 |
| Hyperinsulinism, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Although insulin has been shown to stimulate ovarian steroidogenesis and hyperinsulinaemia has been implicated in the raised androgen levels found in diseases associated with significant insulin resistance, ovarian function has not been studied so far in women with NIDDM. | 8977760 |
| Increased insulin level, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperinsulinemia was defined as fasting insulin > or = 95th percentile (20 microU/mL) among the subset of subjects (n = 504) who were nonobese and free of clinical diabetes and glucose intolerance. | 8978879 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | Genetic and environmental architecture of the features of the insulin-resistance syndrome. | 8981957 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | The contribution of genetic and environmental effects to the clustering of metabolic factors contained in insulin-resistance syndrome (IRS) is still unclear. | 8981957 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Body mass index was higher in subjects with glucose intolerance, but the frequency of obesity showed a relative decrease with worsening of glucose tolerance. | 8982019 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | These results show that glucose intolerance, especially impaired glucose tolerance and undetected diabetes mellitus, is common in the elderly. | 8982019 |
| Dyslipidemias, Cerebrovascular accident, Myocardial Ischemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Diastolic blood pressures were significantly lower (p < 0.05) in patients with stroke and in those with ischemic heart disease, diabetes mellitus, or dyslipidemia, as compared with patients with no comorbidity. | 8986459 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance in patients with a recent diagnosis of coronary artery disease. | 8986933 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | To elucidate whether insulin resistance is present in coronary artery disease (CAD) at diagnosis and to study its relationship with other known cardiovascular risk factors. | 8986933 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Deregulated Nutrient Sensing | The IST consisted of a constant infusion of glucose, insulin and somatostatin for 150 min; insulin resistance was estimated by determining the steady-state plasma glucose (SSPG) concentrations during the last 60 min of the test. | 8986933 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | These results suggest that insulin resistance might play a role in the development of coronary atherosclerosis and that its early diagnosis might be important in the prophylaxis of CAD. | 8986933 |
| CCL21 protein, human | Deregulated Nutrient Sensing | In this young adult African-American population, elevated SLC activity is detected in association with metabolic and lipid alterations typical of insulin resistance. | 9002529 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | The activity of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is associated with insulin resistance (IR) and the risk of venous and arterial thrombotic cardiovascular disease (CVD) in the general population, and may behave as an acute-phase reactant. | 9005966 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system. | 9008254 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | A putative pathogenic mutation in the beta3-adrenergic receptor gene (Trp64Arg) has been reported to be associated with higher diastolic blood pressure as well as clinical features of the insulin resistance syndrome and an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians and Finns. | 9008254 |
| Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | Because essential hypertension is reported to be associated with insulin resistance, we studied the mutation in Japanese patients with essential hypertension to clarify associations of this mutation with hypertension, insulin resistance, and basal adrenergic state in hypertensive subjects. | 9008254 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These data suggest that Trp64Arg mutation in the beta3-adrenergic receptor gene does not play a major role in susceptibility to essential hypertension or in insulin resistance and basal adrenergic state in hypertension. | 9008254 |
| Coronary heart disease | Deregulated Nutrient Sensing | Most discussions of relations of insulin resistance to coronary heart disease risk factors have focused on insulin-stimulated glucose uptake, but insulin suppression of plasma free fatty acid (FFA) levels is also important in lipid and lipoprotein metabolism. | 9012639 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | To identify groups with impaired insulin suppression of FFAs, we studied a multiethnic cohort of 1521 women and men at four US centers that comprise the Insulin Resistance Atherosclerosis Study (IRAS): 682 with normal glucose tolerance, 352 with impaired glucose tolerance, and 487 with non-insulin-dependent diabetes. | 9012639 |
| Noncommunicable Diseases | Deregulated Nutrient Sensing | We could also observe a varying degree of transition in cardiovascular risks related to insulin resistance from the rural to the urban area with rapid emergence of non-communicable diseases as a result of modernization. | 9015672 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In contrast, the peptide does not seem to improve insulin resistance in NIDDM. | 9024239 |
| Dyslipidemias | Deregulated Nutrient Sensing | Furthermore, children with this LDL subclass showed increased body fatness and dyslipidemia, including elevated plasma triglyceride and apolipoprotein (apo) B concentrations and decreased plasma high-density lipoprotein (HDL) cholesterol and apo A-I concentrations, compared with children without this phenotype. | 9030819 |
| Obesity, Abdominal, Diabetes Mellitus, diabetic, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Prompted by the recent findings that a tryptophan to arginine (Trp64Arg) mutation in the beta3-adrenergic receptor gene was associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians, with abdominal obesity and insulin resistance in Finns, and with an increased capacity to gain weight in French whites, we studied the prevalence of this mutation in 231 diabetic and 95 nondiabetic Japanese subjects and assessed its contribution to the development of obesity and NIDDM. | 9030829 |
| Dyslipidemias, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, although the Trp64Arg mutation is not uncommon in Japanese, it does not appear to be associated with obesity, NIDDM, age at diagnosis of NIDDM, or dyslipidemia. | 9030829 |
| Coronary heart disease | Deregulated Nutrient Sensing | There was no evidence of insulin resistance as a major pathogenic factor in the group with coronary heart disease. | 9036291 |
| Increased insulin level, Diabetes Mellitus | Deregulated Nutrient Sensing | Most studies suggest that the maximum benefit from exercise is most likely to occur in patients with mild diabetes in whom insulin resistance and hyperinsulinemia are present (i.e. | 9036570 |
| Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Most patients with cirrhosis have insulin resistance and impaired glucose tolerance, and 20% eventually develop diabetes. | 9039943 |
| NEUROD1 wt Allele, MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder) | Deregulated Nutrient Sensing | In contrast to patients with NIDDM, MODY3 patients did not show any features of the insulin resistance syndrome. | 9045858 |
| Hyperglycemia, physiopathological | Deregulated Nutrient Sensing | Relationship of insulin resistance to microvascular dysfunction in subjects with fasting hyperglycaemia. | 9049487 |
| Hyperinsulinism | Deregulated Nutrient Sensing | These results suggests that hyperinsulinaemia, as a result of insulin resistance, may have a detrimental effect on microvascular function in the prediabetic state. | 9049487 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The prevalence of insulin resistance and other cardiovascular disease risk factors in healthy elderly southwestern Nigerians. | 9050777 |
| Hyperinsulinism, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | the subjects had a relatively high prevalence of multiple CHD risk factors (about 20% had > 4 risk factors), an observation considered paradoxical in view of the reportedly low CHD prevalence in this population; (iii) these CHD risk factors (increased body mass and blood pressure (BP), hyperinsulinaemia and insulin resistance) were more prevalent in the women and in urban residents; (iv) hyperinsulinaemia (20%) and insulin resistance (35%) were common in the population, and were associated, on regression analyses, to such other CHD risk factors as BP and body mass, particularly in women, suggesting, as in Caucasians, that insulin resistance could be an important index of CHD risk; and (v) the excess of multiple CHD risk factors in the women, is due at least in part, to their increased tendency to obesity (8%) and reduced physical activity (83%). | 9050777 |
| Arteriosclerosis, Dyslipidemias, Disease | Deregulated Nutrient Sensing | [Incidence of dyslipidemia and diseases associated with arteriosclerosis in a hospital population]. | 9053820 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia is a major risk factor for atherosclerosis in adults and children. | 9057686 |
| Dyslipidemias, Retinal Diseases, Kidney Diseases, Obesity | Deregulated Nutrient Sensing | AN was associated with retinopathy, with nephropathy (only in IDDM), and with BP levels, but not with dyslipidemia, smoking, or obesity. | 9069569 |
| Primary malignant neoplasm, Gall Bladder Diseases, Gout, Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Arthritis, Respiration Disorders, Overweight, Hypertension, CTCAE | Deregulated Nutrient Sensing | Overweight and obese adults are at increased risk for morbidity and mortality associated with many acute and chronic medical conditions, including hypertension, dyslipidemia, coronary heart disease, diabetes mellitus, gallbladder disease, respiratory disease, some types of cancer, gout, and arthritis. | 9072680 |
| Increased insulin level, No metabolic abnormalities, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Patients with CHD have hyperinsulinemia and subtle metabolic abnormalities related with insulin resistance even in absence of overt risk factors. | 9078598 |
| Obesity | Deregulated Nutrient Sensing | However, in contemporary children obesity is a stronger determinant of insulin level and insulin resistance than size at birth. | 9084971 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | In adults low birthweight and thinness at birth are associated with increased risk of glucose intolerance and non-insulin-dependent diabetes mellitus. | 9084971 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Hypovitaminosis D may be a significant risk factor for glucose intolerance. | 9084975 |
| Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Impaired glucose tolerance resulting from insulin resistance in subjects with cirrhosis or diabetes mellitus is not affected by phlebotomy treatment. | 9088667 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Increased age, higher socioeconomic class, and higher WHR were proven to be independent risk factors for glucose intolerance in either area. | 9096979 |
| deficiency aspects, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with diabetes mellitus, poor image quality is frequently obtained with FDG-PET, due to relative or absolute insulin deficiency and peripheral insulin resistance. | 9106773 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | The Trp64Arg mutation of the beta 3-adrenergic receptor (beta 3AR) is prevalent in several ethnic groups and is associated with weight gain, and some features of syndrome X such as insulin resistance and dyslipidaemia. | 9112025 |
| Obesity, Visceral, Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Nevertheless, it is not known at present whether this mutation is associated with visceral obesity, which is an important risk factor for the development of hypertension, dyslipidaemia, insulin resistance, non-insulin-dependent diabetes mellitus, and atherosclerosis. | 9112025 |
| Liver Cirrhosis, diabetic | Deregulated Nutrient Sensing | Several studies have demonstrated that diabetic patients with cirrhosis require insulin treatment because of insulin resistance. | 9126802 |
| Liver Cirrhosis, diabetic | Deregulated Nutrient Sensing | The aim of this study was to ascertain whether long-term treatment with silymarin is effective in reducing lipoperoxidation and insulin resistance in diabetic patients with cirrhosis. | 9126802 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia causes development of atherosclerosis in chronic hemodialysis patients. | 9132551 |
| Disorder of soft tissue, Dyslipidemias, Blood Vessel, Amyloidosis, Uremia | Deregulated Nutrient Sensing | In uraemia, the rise of AGEs is even more marked than in diabetics and is associated with a variety of tissue disorders including vascular damage, dyslipidaemia, and beta 2-microglobulin amyloidosis. | 9132640 |
| Fatty Liver, Increased insulin level, Obesity | Deregulated Nutrient Sensing | Previous reports have revealed that fatty liver involving obesity is closely related to insulin resistance or hyperinsulinemia in adulthood. | 9138179 |
| Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | From the Insulin Resistance Atherosclerosis Study and the San Luis Valley Diabetes Study. | 9144749 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Persons with non-insulin-dependent diabetes mellitus (NIDDM) are at increased risk for cardiovascular disease, partly due to concomitant worsening of traditional risk factors including dyslipidemia and hypertension. | 9144749 |
| Coronary heart disease | Deregulated Nutrient Sensing | Among this sample of nondiabetic men, moderate drinkers had the lowest levels of fasting insulin resistance index and fasting insulin, consistent with lower levels of insulin resistance and thus lower risk for coronary heart disease. | 9149662 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | These considerations rationalize many findings in animal and epidemiologic studies, and suggest that non-diabetic insulin resistance may be a significant cancer risk factor. | 9160283 |
| Atherosclerosis | Deregulated Nutrient Sensing | Increased IGF activity associated with insulin resistance may also promote benign hyperplasias-most notably atherosclerosis. | 9160283 |
| Coronary heart disease | Deregulated Nutrient Sensing | This study does not support the concept that insulin resistance is an early atherogenic risk factor in offspring at risk for coronary disease because of their family history. | 9160815 |
| Hypertension, CTCAE, Infection, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The screen revealed high rates of smoking and excessive drinking, of preventable infections and their sequelae, and of hypertension, insulin resistance, diabetes and renal disease. | 9161065 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | We suggest that the sympathetic nervous system may be involved in the pathophysiology of the characteristic insulin resistance or metabolic cardiovascular syndrome in young men. | 9162435 |
| Massive Osteolyses, Glycogen Storage Disease, Dyslipidemias, Disease | Deregulated Nutrient Sensing | Liver glycogen storage diseases (GSD) are disorders associated with severe dyslipidaemia which can induce cell membrane alterations and possibly reduced cell deformability. | 9163069 |
| Weight Gain | Deregulated Nutrient Sensing | However, it is unknown whether insulin secretion rises to compensate for insulin resistance or high insulin secretion promotes body weight gain and the development of insulin resistance. | 9166675 |
| Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The triglyceride-lowering effects of omega-3 fats and HDL cholesterol-raising effects of exercise may be appropriate management for dyslipidemia in NIDDM. | 9167099 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The age-standardized prevalence of dyslipidaemia increased in each location between 1978 (n = 1197) and 1991 (n = 1748) with the prevalence of hypercholesterolaemia (> or = 5.5 mmol/l) increasing from 18% to 36% (P < 0.001), and that of hypertriglyceridaemia (> or = 2.0 mmol/l) increasing from 9% to 15% (P < 0.001) in the capital city, Apia. | 9169164 |
| Dyslipidemias | Deregulated Nutrient Sensing | Current levels of dyslipidaemia in Western Samoa are similar to those observed in developed Western populations, and are increasing rapidly. | 9169164 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | Among the hypertensives, there was a 2.0- to 3.6-fold higher risk of having a clustering of the insulin-resistance associated cardiovascular risk factors compared with that of the normotensives. | 9169999 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Among the hypertensive subjects in the highest quartile of fasting plasma insulin there was a six- to 12-fold increase in risk associated with having two or more insulin resistance-associated cardiovascular risk factors compared with the subjects in the lowest quartile. | 9169999 |
| Breast Carcinoma, Hyperinsulinism, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | While most examined conditions seemed unrelated to breast cancer risk, the association with late-onset diabetes is of special interest as it suggests a role of hyperinsulinaemia and insulin resistance in breast cancer promotion. | 9184190 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | High triglyceride (TG) and low HDL cholesterol (HDL-C) is the characteristic dyslipidemia seen in insulin-resistant subjects. | 9194762 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | In conclusion, the present results showed that high TG-low HDL-C, the characteristic dyslipidemia seen in insulin-resistant subjects, was at least as powerful a predictor of IHD as isolated high LDL-C. | 9194762 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | It is suggested that an increase in mean BMI to the levels in the Europid population will be associated with a substantial increase in glucose intolerance in Chinese people. | 9196645 |
| Hyperandrogenism | Deregulated Nutrient Sensing | A useful test to determine insulin resistance in obese hyperandrogenic women]. | 9196992 |
| Coronary Arteriosclerosis, Myocardial Ischemia, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, we demonstrated frequent disturbances in glucose metabolism indicating insulin resistance in patients with ischemic heart disease without a history of diabetes, but we could not demonstrate a relation between these disturbances and degree of coronary atherosclerosis. | 9200389 |
| Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | Potential mechanisms for the relationship of higher complex levels and diabetic complications include an altered fibrinolytic response and/or insulin resistance. | 9201602 |
| Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | The diabetes or impaired glucose tolerance that occurs in most patients with pancreatic cancer is characterized by profound insulin resistance. | 9211494 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | [Prevalence of glucose intolerance, diabetes mellitus, and high serum insulin levels in a Japanese urban population]. | 9212655 |
| Increased insulin level, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | An epidemiological study was conducted to investigate the prevalence of diabetes mellitus, glucose intolerance and hyperinsulinemia in an urban population. | 9212655 |
| Increased insulin level | Deregulated Nutrient Sensing | This syndrome is characterized by a persistent state of insulin resistance and compensatory hyperinsulinemia that may be etiologically related to the four risk factors. | 9214569 |
| Vascular Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Clustering of risk factors for cardiovascular disease related to insulin resistance may account for the increased incidence of vascular disease in these conditions and in non-diabetic subjects. | 9218152 |
| Cardiac complication, Hypertension, CTCAE | Deregulated Nutrient Sensing | Influence of aging on progression of cardiovascular complications associated with insulin resistance in patients with essential hypertension. | 9220277 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperinsulinemia or insulin resistance is suggested to play a role in the pathogenesis of hypertension and its target organ diseases. | 9220277 |
| Cardiac Hypertrophy, Hypertensive (finding), Hypertension, CTCAE, Atherosclerosis | Deregulated Nutrient Sensing | These results suggest that aging decreases insulin sensitivity even in essential hypertensive subjects and that insulin resistance does not affect the progression of cardiac hypertrophy and atherosclerosis in elderly patients with essential hypertension. | 9220277 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Renal function and insulin resistance as determinants of plasma leptin levels in patients with NIDDM. | 9222647 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the influences of renal function and insulin resistance on plasma leptin concentrations, we measured plasma leptin concentrations and performed the euglycaemic hyperinsulinaemic clamp studies in 57 patients with non-insulin-dependent diabetes mellitus with a wide range of renal function. | 9222647 |
| Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Comparison of bezafibrate and simvastatin in the treatment of dyslipidaemia in patients with NIDDM. | 9223394 |
| Dyslipidemias | Deregulated Nutrient Sensing | Fibrates and HMG CoA reductase inhibitors are commonly used in the treatment of diabetic dyslipidaemia. | 9223394 |
| Glucose Intolerance (disease), Cirrhotic | Deregulated Nutrient Sensing | Glucose intolerance is encountered in the majority of cirrhotic patients. | 9225841 |
| Hypertriglyceridemia, Dyslipidemias, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Acipimox, being widely prescribed for treating hypertriglyceridemia, is also used in NIDDM patients for their dyslipidemia. | 9229195 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Impairment of endothelium-dependent relaxation is related to dyslipidemia and may be an early marker for atherosclerosis in angiographically smooth arteries. | 9231040 |
| Weight Gain | Deregulated Nutrient Sensing | In contrast, longitudinal studies in adults show that insulin sensitivity and low fasting insulin concentrations are associated with increased weight gain, whereas insulin resistance seems to protect against weight gain. | 9231660 |
| Dyslipidemias | Deregulated Nutrient Sensing | The use of AAD, although clinically safe and without side effects, had no effect on the dyslipidemia in our group of CAPD patients. | 9237290 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationships of C-peptide levels and the C-peptide/bloodsugar ratio with clinical/biochemical variables associated with insulin resistance in orally-treated, well-controlled type 2 diabetic patients. | 9237784 |
| Hypertension, CTCAE, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Although insulin resistance has been involved in the pathogenesis of essential hypertension in non-diabetic patients, few studies were performed regarding to the association between insulin resistance, hypertension and nephropathy in diabetes mellitus. | 9240760 |
| Diabetic Nephropathy, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | These results suggest that insulin resistance is involved in the etiology of hypertension in NIDDM patients, and that this derangement has an important role for the progression of diabetic nephropathy. | 9240760 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Intra-abdominal fat, lipid metabolism and insulin resistance in coronary artery disease. | 9240769 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Clinical impact of insulin resistance syndrome in cardiovascular diseases and its therapeutic approach. | 9240771 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Insulin resistance significantly correlated with coronary atherosclerosis score. | 9240771 |
| doxorubicin/procarbazine/vincristine protocol | Deregulated Nutrient Sensing | Insulin resistance syndrome who fulfilled all the criteria was 9-10% for VAP. | 9240771 |
| Increased insulin level | Deregulated Nutrient Sensing | In atherothrombotic brain infarction (ATTI) with the same exclusion criteria, the similar insulin resistance and hyperinsulinemia have been observed, but not in embolic (cardiac origin) or lacunar infarction. | 9240771 |
| Increased insulin level, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In essential hypertension without diabetes and obesity, hyperinsulinemia was noted in 25-35% and insulin resistance in 56-88%. | 9240771 |
| Increased insulin level | Deregulated Nutrient Sensing | Insulin resistance rather than hyperinsulinemia is more closely associated with blood pressure. | 9240771 |
| Cardiovascular Diseases, Diabetes Mellitus, Angina Pectoris, Variant, Arteriopathic disease | Deregulated Nutrient Sensing | Cardiovascular diseases (vasospastic and obstructive AP, brain cortical artery diseases) are prone to develop diabetes because of insulin resistance and also promote the generation of cumulative risk factors resulting in a vicious cycle. | 9240771 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Efforts to alleviate insulin resistance is crucial for the primary and secondary prevention of cardiovascular diseases. | 9240771 |
| Cancer-related fatigue, Hyperinsulinism | Deregulated Nutrient Sensing | This suggests that insulin resistance and hyperinsulinaemia contribute to elevated serum leptin concentrations in CRF. | 9249764 |
| Cancer-related fatigue, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Consequently, extremely elevated serum leptin may play a role in reducing glucose-stimulated insulin secretion and glucose intolerance in CRF. | 9249764 |
| Diabetic Nephropathy, Dyslipidemias | Deregulated Nutrient Sensing | Recent studies suggest that dyslipidaemia accelerates the progression of diabetic nephropathy, but the various pathomechanisms underlying such abnormalities are not completely delineated. | 9249767 |
| Renal Insufficiency, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We isolated, radiolabelled, and characterized very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL) from eight diabetic patients with moderate impairment of renal function and dyslipidaemia and studied their interaction with LDL receptors in human glomerular epithelial cells. | 9249767 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Insulin resistance with altered secretory kinetics and reduced proinsulin in cystic fibrosis patients. | 9252906 |
| Congenital glucose-galactose malabsorption | Deregulated Nutrient Sensing | The ratio of glucose to insulin, an indicator of insulin resistance, increased in CF patients with progression of carbohydrate intolerance. | 9252906 |
| Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | In CF patients with impaired glucose tolerance or diabetes, integrated insulin release is not diminished, indicating that insulin resistance is likely to contribute to hyperglycemia in CF patients with IGT or DM. | 9252906 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | These data indicate that the Asp905Tyr polymorphism of the PP1 G subunit is not associated with essential hypertension, nor with insulin resistance and/or hyperinsulinemia in Japanese patients with essential hypertension, suggesting that the polymorphism plays little if any role in susceptibility to insulin resistance or hypertension. | 9260986 |
| Dyslipidemias | Deregulated Nutrient Sensing | The risk associated with the apo E polymorphism is unrelated to dyslipidemia. | 9261250 |
| Coronary Artery Disease, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is known to be associated with atherosclerosis and coronary artery disease. | 9267146 |
| Glucose Intolerance (disease), Coronary Artery Disease | Deregulated Nutrient Sensing | These data suggest that aging is associated with glucose intolerance, insulin resistance, and an increased risk of coronary artery disease, but that the effect of aging on coronary artery disease cannot be explained by insulin resistance alone. | 9267146 |
| Glucose Intolerance (disease), Coronary Artery Disease | Deregulated Nutrient Sensing | Other factors, such as glucose intolerance and increased blood pressure, in addition to insulin resistance, appear to be responsible of the increased risk for coronary artery disease in the elderly. | 9267146 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia have been linked to essential hypertension. | 9267147 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | These results indicate that 1) reduction in insulin sensitivity plays a role in age-related acceleration of hypertension and of glucose intolerance; 2) in patients with essential hypertension, selective insulin resistance with respect to glucose metabolism can be found even in those who are young; and 3) both sodium retention and pressor system activation via insulin might cause blood pressure to increase in patients with essential hypertension. | 9267147 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Some epidemiological studies showed that the prevalence of hypertension, glucose intolerance, and diabetes mellitus increase with advancing age. | 9267147 |
| diabetic, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Muscle glycogen synthase (GYS1) is a key enzyme of non-oxidative pathway of glucose metabolism that has been reported to be related to insulin resistance in non-insulin-dependent diabetic (NIDDM) patients. | 9267990 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | These findings indicate that the M416V mutation of the GYS1 gene is one of the factors contributing to the insulin resistance in the Japanese population and may play some role in the pathogenesis of NIDDM. | 9267990 |
| Malignant Neoplasms, Diabetes Mellitus, Non-Insulin-Dependent, Syndrome, Cardiovascular Diseases | Deregulated Nutrient Sensing | For example, occurrence of different cancers within pedigrees was suggestive of familial cancer syndromes, and clustering of noninsulin-dependent diabetes and cardiovascular disease suggested an insulin resistance syndrome. | 9268102 |
| Increased insulin level, Cardiovascular Diseases | Deregulated Nutrient Sensing | The authors conclude that a clustering of cardiovascular disease risk factors in nondiabetic subjects is not only associated with hyperinsulinemia but also with insulin resistance. | 9270410 |
| Cushing Syndrome | Deregulated Nutrient Sensing | Although it is well established that hypercortisolism causes insulin resistance, the mechanisms responsible for impaired insulin action in Cushing's syndrome are unclear. | 9274705 |
| Cushing Syndrome | Deregulated Nutrient Sensing | Patients with Cushing's syndrome show marked peripheral insulin resistance and enhanced hepatic G/G6P cycle activity. | 9274705 |
| Hyperinsulinism | Deregulated Nutrient Sensing | During hyperinsulinaemia G/G6P cycle activity was increased but insulin resistance was predominantly due to reduced peripheral glucose uptake. | 9274705 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Results thus suggest that acarbose improved insulin resistance in some patients with NIDDM (responders as classified by principal component analysis). | 9279483 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Effect of acarbose on glucose intolerance in patients with non-insulin-dependent diabetes mellitus. | 9279483 |
| Glucose Intolerance (disease), Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | We evaluated the effect of acarbose, an alpha-glucosidase inhibitor, on glucose intolerance in patients with non-insulin-dependent diabetes mellitus (NIDDM). | 9279483 |
| Increased insulin level, Glucose Intolerance (disease), Ovarian Hyperandrogenism, Obesity | Deregulated Nutrient Sensing | Ovarian hyperandrogenism can be associated with insulin resistance, hyperinsulinemia, glucose intolerance, and obesity. | 9284746 |
| Diabetic Nephropathy, diabetic | Deregulated Nutrient Sensing | Insulin resistance in non-obese, non-insulin-dependent diabetic patients with diabetic nephropathy. | 9284889 |
| Diabetic Nephropathy, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To investigate the association between insulin resistance and diabetic nephropathy, peripheral insulin sensitivity indices (M/I values) were evaluated via euglycemic-hyperinsulinemic clamp in 45 non-obese, non-insulin-dependent diabetic (NIDDM) subjects. | 9284889 |
| Microalbuminuria, Kidney Diseases, Obesity, Uremia, NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, the present cross-sectional study demonstrated in non-obese NIDDM patients with nephropathy that microalbuminuria did not affect peripheral insulin resistance, but uremia did, as in nondiabetic patients, and that the peripheral insulin resistance was significantly contributed to by the degree of obesity and uremia. | 9284889 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Whole body insulin resistance characterizes patients with NIDDM, but it is not known whether insulin also has impaired ability to stimulate myocardial glucose uptake (MGU) in these patients. | 9287051 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | As studied by [18F]FDG PET under stable normoglycemic hyperinsulinemic conditions, MGU is not reduced in patients with NIDDM and CAD in spite of peripheral insulin resistance. | 9287051 |
| Vascular Diseases, Hypertriglyceridemia, Hyperinsulinism | Deregulated Nutrient Sensing | Both hyperinsulinaemia and insulin resistance are associated with fasting hypertriglyceridaemia and both increased VLDL production and increased plasma triglyceride concentrations commonly occur in association with abnormal glucose tolerance and atheromatous vascular disease. | 9288540 |
| Vascular Diseases | Deregulated Nutrient Sensing | We suggest that abnormal NEFA suppression plays an important part in the increase in risk of vascular disease associated with insulin resistance. | 9288540 |
| Microalbuminuria, Peripheral Vascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Diabetic Nephropathy | Deregulated Nutrient Sensing | It is concluded that microalbuminuria in Type 2 diabetes reflects both the existence of diabetic nephropathy and peripheral vascular disease which is often associated with the insulin resistance syndrome. | 9288546 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Our data suggest that a high plasma NEFA concentration is a risk marker for deterioration of glucose tolerance independent of the insulin resistance or the insulin secretion defect that characterize subjects at risk for NIDDM. | 9300248 |
| Sialorrhea, Obesity | Deregulated Nutrient Sensing | Insulin resistance and insulin hypersecretion are established features of obesity. | 9303923 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | In nondiabetic, normotensive obese subjects, the prevalence of insulin resistance is relatively low, and is exceeded by the prevalence of insulin hypersecretion, particularly in women with central obesity. | 9303923 |
| Chronic glomerulonephritis, Dyslipidemias | Deregulated Nutrient Sensing | In the more homogeneous subgroup of patients with chronic glomerulonephritis the association between dyslipidaemia and the rate of progression was even more pronounced. | 9306342 |
| Increased insulin level, Glucose Intolerance (disease), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Insulin resistance has been hypothesized to unify the clustering of hypertension, glucose intolerance, hyperinsulinemia, increased levels of triglyceride and decreased HDL cholesterol, and central and overall obesity. | 9313755 |
| Increased insulin level | Deregulated Nutrient Sensing | Insulin resistance (reflected by hyperinsulinemia) alone did not appear to underlie all features of the insulin resistance syndrome. | 9313755 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Glucose intolerance and hypertension were linked to the central syndrome through shared correlations with insulin levels and obesity. | 9313755 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality. | 9322802 |
| Chronic disease | Deregulated Nutrient Sensing | Japanese individuals living outside Japan are more susceptible to chronic diseases included in the insulin resistance syndrome. | 9322996 |
| Increased insulin level, Glucose Intolerance (disease), Overweight | Deregulated Nutrient Sensing | The association of overweight, hyperinsulinemia, glucose intolerance, and high blood pressure can be detected early, but the significance of these findings would be better explained by longitudinal studies. | 9322998 |
| Obesity | Deregulated Nutrient Sensing | Raised serum urate appears to be an integral part of the cluster of risk factors associated with the insulin resistance syndrome that include obesity, raised serum triglycerides, and serum cholesterol. | 9326988 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Gemfibrozil treatment of hypertriglyceridemia: improvement on fibrinolysis without change of insulin resistance. | 9327717 |
| Hepatobiliary Disorder, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Liver disease is accompanied by "insulin resistance" of glucose metabolism, whereby glucose intolerance occurs despite relatively increased plasma insulin concentration. | 9346691 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | This study shows that in Vietnamese people, essential hypertension is associated with a significant increase in BMI, which however remains far lower than the definition threshold of occidental obesity and with a state of insulin resistance found despite very slight or no excess weight. | 9347408 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | It is concluded that moderate salt restriction seems not to adversely influence insulin resistance or serum lipids in hypertensive patients. | 9350069 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Early insulin-secretion abnormalities may be the very first step towards the development of insulin resistance and an important factor initiating the hypertension in hypertension-prone individuals. | 9350591 |
| Increased insulin level, Atherosclerosis, Congenital Abnormality | Deregulated Nutrient Sensing | It has been suggested that insulin resistance and consequent hyperinsulinemia promote atherosclerosis, but few prospective studies have reported the relationships between hyperinsulinemia and the development of ST-T abnormalities in the 12-lead resting electrocardiogram (ECG) in populations in which atherosclerosis is rare. | 9353609 |
| Increased insulin level, Glucose Intolerance (disease), Congenital Abnormality, Atherosclerosis | Deregulated Nutrient Sensing | Hyperinsulinemia was related to the development of ST-T abnormalities in ECGs in the absence of the development of clinical signs of atherosclerosis, independent of blood pressure and other risk factors in men and women with mild glucose intolerance. | 9353609 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | The fact that significant metabolic improvement was seen in the obese nondiabetic hyperinsulinemic women studied suggests that Ergoset could be of therapeutic benefit in clinical conditions of hyperglycemia and/or dyslipidemia. | 9353611 |
| Arteriosclerosis Obliterans, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance and arteriosclerosis obliterans in patients with NIDDM. | 9353618 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The chromium requirement is postulated to increase with increased glucose intolerance and diabetes. | 9356027 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin sensitivity and intake of vitamins E and C in African American, Hispanic, and non-Hispanic white men and women: the Insulin Resistance and Atherosclerosis Study (IRAS). | 9356542 |
| Atherosclerosis, Diabetes Mellitus, Obesity, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Elevated fasting insulin concentrations and insulin resistance have been associated with non-insulin-dependent diabetes mellitus (NIDDM), obesity, atherosclerosis, and hypertension. | 9356542 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Cigarette smoking and insulin resistance in patients with noninsulin-dependent diabetes mellitus. | 9360516 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, chronic cigarette smoking seems to markedly aggravate insulin resistance in patients with NIDDM. | 9360516 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Thus, a low Mg concentration in nondiabetic subjects was associated with relative insulin resistance, glucose intolerance, and hyperinsulinemia. | 9360541 |
| Increased insulin level, Hypertension, CTCAE, Diabetes Mellitus, Coronary heart disease | Deregulated Nutrient Sensing | Hyperinsulinemia is associated with insulin resistance and with the development of diabetes, hypertension, and coronary heart disease. | 9361683 |
| Skeletal muscle weakness | Deregulated Nutrient Sensing | The findings suggest that skeletal muscle weakness may precede and predict the development of insulin resistance, and raise the intriguing possibility of some common cause in skeletal muscle pathophysiology. | 9361683 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | There was a progressive increase with age in the prevalence of glucose intolerance, hypertension, dyslipidaemia and obesity. | 9363738 |
| Adenoma, Carcinoma, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | There was a trend toward increased incidence of glucose intolerance among carcinoma patients but no significant differences in clinical signs or symptoms between adenoma and carcinoma patients could be made. | 9366310 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study. | 9366728 |
| Alzheimers Disease | Deregulated Nutrient Sensing | To determine the association between features of the insulin resistance syndrome and Alzheimer's disease. | 9366728 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Presence of features of the insulin resistance syndrome and diagnosis of Alzheimer's disease by detailed neurological and neuropsychological evaluation. | 9366728 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Features of the insulin resistance syndrome are associated with Alzheimer's disease independently of apolipoprotein E4 phenotype. | 9366728 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Cox models were used to adjust for age, sex, smoking, glucose intolerance, total cholesterol, and prior cardiovascular disease. | 9369249 |
| Increased insulin level, Obesity | Deregulated Nutrient Sensing | Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. | 9369268 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is thought to be a pathogenetic factor, predisposing genetically prone individuals to develop the microvascular complications of diabetes. | 9371478 |
| Glucose Intolerance (disease), Kidney Diseases, diabetic | Deregulated Nutrient Sensing | We conclude that offspring of diabetic parents with nephropathy do not show higher risk of glucose intolerance or insulin resistance compared to those with diabetic parents without nephropathy. | 9371478 |
| diabetic | Deregulated Nutrient Sensing | The relatively high plasma glucose values in the presence of normal insulin secretion in both groups of offspring of diabetic parents suggest the presence of insulin resistance. | 9371478 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Increased prednisolone dose and older age are strongly associated with the development of posttransplant glucose intolerance. | 9381545 |
| Glucose Intolerance (disease), Hypertriglyceridemia, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Each one of the three diets was offered ad libitum to adult rats of line IIMb/Fm beta (beta), affected by obesity, hypertriglyceridemia and glucose intolerance or diabetes. | 9382678 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Our data suggest that the polymorphisms at the LPL gene, as the linkage markers with an aetiologic mutation at or around LPL gene, may constitute one of the genetic determinants for the population variation in plasma TG levels, as well as for the common dyslipidemia in Chinese populations. | 9387400 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Impaired glycogen synthesis after insulin stimulation accounts for most of the insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM). | 9389424 |
| NEUROD1 wt Allele, diabetic | Deregulated Nutrient Sensing | In conclusion, the new Gln71His and Met416Val substitutions and other variants of the glycogen synthase gene are unlikely to make a major contribution to insulin resistance and NIDDM in diabetic patients from eastern Finland. | 9389424 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Non-insulin-dependent diabetes mellitus (NIDDM) is caused by peripheral insulin resistance and impaired beta cell function. | 9389749 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Deregulated Nutrient Sensing | The IST showed marked insulin resistance in both parents and the older, homozygous son, and moderate resistance in the younger son. | 9389749 |
| Weight Gain, NEUROD1 wt Allele, Increase in blood pressure | Deregulated Nutrient Sensing | We reached the following conclusions: 1) after an initial good response, glycemic control deteriorates more in obese than in nonobese patients with NIDDM; 2) in obese patients, weight gain per se cannot explain the poor glycemic response to combination or insulin therapy, but it may induce a disproportionately large increase in insulin requirements because of greater insulin resistance in the obese than in the nonobese; 3) in nonobese patients, glycemic control improves equally during 1 yr with combination therapy with insulin and insulin alone, but combination therapy with insulin is associated with less weight gain than treatment with insulin alone; 4) weight gain appears harmful, as it is associated with increases in blood pressure and low density lipoprotein cholesterol. | 9398709 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | [Insulin resistance and essential hypertension in Vietnamese subjects]. | 9404424 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Several epidemiological and experimental studies suggest that essential arterial hypertension is associated with hyperinsulinism and insulin resistance in obese subjects and also in subjects with normal body weight. | 9404424 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The aim of this study was to look for insulin resistance in hypertensive Vietnamese subjects, despite a markedly lower BMI in Vietnam than in occidental countries. | 9404424 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Thus, despite under-nutrition, hypertensive Vietnamese patients have a moderate but significant increase in BMI and fat mass without predominant abdominal localization, and a state of insulin-resistance, compared with normotensive healthy subjects. | 9404424 |
| Beta-cell dysfunction, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | In the Korean population, beta-cell dysfunction, as measured by high proinsulin levels, seems to be associated with subsequent development of NIDDM, whereas regional and general obesity and fasting insulin levels, which may be a surrogate for insulin resistance, were not. | 9405904 |
| Coronary heart disease | Deregulated Nutrient Sensing | Relation of LDL size to the insulin resistance syndrome and coronary heart disease in American Indians. | 9409247 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Small, dense LDL has been shown to be associated with the insulin resistance syndrome and coronary heart disease (CHD). | 9409247 |
| Thickened, Angina Pectoris, Variant | Deregulated Nutrient Sensing | Insulin resistance as an independent risk factor for carotid artery wall intima media thickening in vasospastic angina. | 9409326 |
| Increased insulin level, Coronary Artery Disease, Angina Pectoris, Variant | Deregulated Nutrient Sensing | Studies have shown the presence of insulin resistance together with compensatory hyperinsulinemia in vasospastic angina as well as obstructive coronary artery disease. | 9409326 |
| Dental Plaque, Angina Pectoris, Variant | Deregulated Nutrient Sensing | The patients with vasospastic angina showed a significant increase in the average intima media thickness of the carotid wall and frequency of plaque formation, although they were comparable to the control subjects in risk factors other than insulin resistance. | 9409326 |
| Increased insulin level, Coronary Artery Vasospasm, Atherosclerosis | Deregulated Nutrient Sensing | These results suggest that insulin resistance in association with compensatory hyperinsulinemia may be an important pathogenic factor for the development of coronary artery spasms and systemic early atherosclerosis. | 9409326 |
| Hypertensive (finding), NEUROD1 wt Allele | Deregulated Nutrient Sensing | These findings indicate that, in hypertensive patients with NIDDM, ie, in subjects who have established insulin resistance, treatment with nebivolol and atenolol neither further deteriorated insulin sensitivity nor adversely affected the lipid profile. | 9416986 |
| Hyperglycemia, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Hyperglycemia rather than insulin resistance is related to reduced coronary flow reserve in NIDDM. | 9421384 |
| Hyperglycemia, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To clarify if coronary flow reserve (CFR) is related to insulin resistance or hyperglycemia in normotensive NIDDM, myocardial blood flow (MBF) at baseline and during dipyridamole loading were measured with 13N-ammonia positron-emission tomography. | 9421384 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | CFR in patients with well-controlled NIDDM was significantly higher than in those with poorly controlled NIDDM, whereas insulin resistance was comparable between the two groups. | 9421384 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | CFR in NIDDM patients was not related to the degree of insulin resistance. | 9421384 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, control of blood glucose concentration rather than insulin resistance is most likely related to the reduced CFR in NIDDM. | 9421384 |
| Hyperlipidemia, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | This is caused, at least in part, by a higher prevalence of obesity-related coronary risk factors such as hyperlipidemia, hypertension, sedentary lifestyle, insulin resistance, and diabetes. | 9421764 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes. | 9425261 |
| Chronic liver disease, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance and diabetes mellitus are both prevalent in patients with chronic liver diseases. | 9430016 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | NaCl sensitivity of essential hypertensive patients is related to insulin resistance. | 9431856 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Insulin resistance was not associated with overt hyperinsulinaemia among these patients. | 9431856 |
| Hypertensive (finding), Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | To evaluate insulin sensitivity of essential hypertensive patients with different salt sensitivities of blood pressure in the absence of confounding factors such as obesity, glucose intolerance and the inclusion both of normotensive and of hypertensive subjects that have affected most previous studies. | 9431856 |
| Hypertensive (finding), Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | This study showed that essential hypertensive patients with high NaCl sensitivities were relatively insulin resistant compared with those with low NaCl sensitivities, independently of confounding factors such as age, obesity and glucose intolerance. | 9431856 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Additional therapy for hypertension and dyslipidemia was started if necessary. | 9439556 |
| Obesity | Deregulated Nutrient Sensing | Low levels of DHA and other LCPUFAs in skeletal muscle membrane phospholipid are associated with insulin resistance and obesity in adults. | 9440487 |
| Disease | Deregulated Nutrient Sensing | Early changes in skeletal muscle membrane phospholipid FA saturation may play a role in the subsequent development of diseases associated with insulin resistance. | 9440487 |
| Increased insulin level | Deregulated Nutrient Sensing | Previous work in younger males with recurrent idiopathic calcium urolithiasis (RCU) demonstrated inappropriately high postprandial phosphaturia, hyperinsulinemia and insulin resistance, but normal glycemia. | 9443652 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Intensive risk factor reduction in patients with dyslipidemias and coronary atherosclerosis has been shown to result in alterations in coronary artery morphology and reduced clinical events. | 9444880 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The data suggest that pravastatin is effective and safe in the treatment of dyslipidemia in both type-1 and type-2 diabetic patients. | 9451475 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Results show that expression of hybrids is increased in fat of NIDDM patients compared to control subjects and is correlated with in vivo insulin sensitivity thus raising the possibility that alterations in expression of hybrids which bind IGF-I with higher affinity than insulin may contribute, at least in part, to insulin resistance. | 9453239 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The results suggest that celiprolol improves insulin sensitivity of hypertensive patients with dyslipidemia in long-term therapy. | 9456288 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, the results indicate that, in microalbuminuric NIDDM patients, effective treatment of dyslipidaemia could be associated with stabilization of urinary albumin excretion. | 9466127 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Recent retrospective studies of older adults have demonstrated a correlation between lower birth weight and hypertension and insulin resistance. | 9470007 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | 'True' fasting serum insulin level, insulin resistance syndrome and coronary artery disease. | 9472456 |
| Hypoglycemia, Atherosclerosis | Deregulated Nutrient Sensing | Increased fasting serum insulin level not associated with hypoglycemia is considered to be a practical indicator of the insulin resistance syndrome, a frequent risk factor for atherosclerosis in industrialized countries. | 9472456 |
| Apolipoproteins B, Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Obesity | Deregulated Nutrient Sensing | There was a significant correlation between elevated 'true' fasting serum insulin level and various constituents of the insulin resistance syndrome, such as obesity, dyslipidemia (hypertriglyceridemia, increased apolipoprotein B and decreased high-density lipoprotein cholesterol and apolipoprotein A1 concentrations), increased serum glucose, uric acid levels, and plasminogen activator inhibitor type I concentration, as well as increased frequency of diabetes. | 9472456 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | An increase of 'true' fasting serum insulin level is a useful practical index to identify patients with the insulin resistance syndrome exposed to increased risk of coronary artery disease. | 9472456 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Insulin resistance has been related to the pathogenesis and development of ischemic heart disease (IHD). | 9479557 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | The aim of this study was to clarify the relationship between insulin resistance and DHEA-S in patients with IHD. | 9479557 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Insulin resistance, defined as an insulin sensitivity index (ISI) below the normal range derived from the control group, was present in 78% of IHD patients; they also displayed, as a group, lower ISI (P < 0.0001) than controls. | 9479557 |
| No metabolic abnormalities, Myocardial Ischemia | Deregulated Nutrient Sensing | In conclusion, insulin sensitivity is lower in patients with IHD, even when major metabolic abnormalities associated with insulin resistance are excluded. | 9479557 |
| Proteinuria, Hypercholesterolemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Female prevalence rates of glucose intolerance, hypercholesterolemia and proteinuria were significantly higher in 25-27 BMI than in 23-25. | 9483954 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Cross-sectional measurements at age 70 showed that high 24-hour BP, nondipping, insulin resistance, and diabetes all were related to low cognitive function. | 9495261 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Reduced peripheral sensitivity to insulin-stimulated glucose disposal, insulin resistance, is considered to be central in the metabolic cardiovascular syndrome. | 9495639 |
| Atherosclerosis | Deregulated Nutrient Sensing | Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. | 9496984 |
| Atherosclerosis | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study, conducted in Oakland, Calif; Los Angeles, Calif; the San Luis Valley, Colo; and San Antonio, Tex. | 9496984 |
| Glucose Intolerance (disease), Hypertriglyceridemia | Deregulated Nutrient Sensing | Hypertriglyceridaemia is associated with glucose intolerance and insulin resistance. | 9502184 |
| Dyslipidemias, Vascular Diseases, Hypertension, CTCAE, atherosclerotic | Deregulated Nutrient Sensing | We can confirm that hypertension and dyslipidaemia, which are two of the main risk factors for vascular diseases on an atherosclerotic basis, are often associated. | 9504350 |
| Acute myocardial infarction | Deregulated Nutrient Sensing | Dyslipidemias have a detrimental effect on left ventricular systolic function in patients with a first acute myocardial infarction. | 9514445 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Categorical definitions for glucose intolerance imply that risk thresholds exist, but metabolic risk for type 2 diabetes mellitus or cardiovascular disease may increase continuously as glucose intolerance increases. | 9518396 |
| Increased insulin level, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Insulin resistance or compensatory hyperinsulinemia has been associated with hypertension and dyslipidemia in cross-sectional studies. | 9519724 |
| Increased insulin level, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. | 9519724 |
| Increased insulin level, Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These findings demonstrate the role of hyperinsulinemia in incident hypertension and dyslipidemia and suggest that both hypertension and dyslipidemia are associated with insulin metabolism disturbance, independently of obesity and body weight. | 9519724 |
| diabetic | Deregulated Nutrient Sensing | Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men. | 9525530 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These consistently identified composite factors may represent markers for underlying pathophysiologic mechanisms of the insulin resistance syndrome and risk of non-insulin-dependent diabetes mellitus. | 9525530 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Hypertension is no longer rare in Alaska Natives and is associated with overweight, non-indigenous diet, mechanized activities, and glucose intolerance. | 9526689 |
| Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To study the regulation of the interstitial glucose concentration in skeletal muscle, nine control subjects and nine older and overweight non-insulin-dependent diabetes mellitus (NIDDM) subjects with extreme insulin resistance were investigated with microdialysis in the medial femoral muscle before and during a euglycemic insulin clamp. | 9530127 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle. | 9535149 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The association between hypertension and insulin resistance might be explained by increased activity of the principal glucocorticoid, cortisol. | 9535410 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | In this report, we examine whether increased glucocorticoid sensitivity or secretion is associated with insulin resistance and is a cause or consequence of hypertension. | 9535410 |
| Hyperglycemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | In both populations, increased dermal glucocorticoid sensitivity was associated with relative hypertension, insulin resistance, and hyperglycemia. | 9535410 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | It may be mediated by an abnormal glucocorticoid receptor, and it may contribute to the association between hypertension and insulin resistance. | 9535410 |
| Acromegaly, Diabetic Ketoacidosis | Deregulated Nutrient Sensing | Acromegaly in a woman presenting with diabetic ketoacidosis and insulin resistance. | 9536592 |
| Acromegaly | Deregulated Nutrient Sensing | Acromegaly should be considered in the differential diagnosis of unexplained insulin resistance. | 9536592 |
| Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Susceptibility to insulin resistance in Arabian peninsula men is strongly supported, suggesting that control of obesity and promotion of exercise are the best approach to CHD prevention. | 9537269 |
| Hyperlipidemia, Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | Familial combined hyperlipidaemia (FCHL) represents the most common genetic dyslipidemia with a prevalence of 1.0-2.0%. | 9537421 |
| Obesity | Deregulated Nutrient Sensing | These specific assays for insulin indicate that after adjusting for obesity nondiabetic Pima Indians are truly hyperinsulinemic, which is consistent with their insulin resistance as measured by other methods. | 9538983 |
| Irregular Menstruation, Increased insulin level, Diabetes Mellitus, Hyperandrogenism | Deregulated Nutrient Sensing | This association may be because of insulin resistance and hyperinsulinemia, which predict type 2 diabetes, also causing hyperandrogenism and menstrual irregularity. | 9540014 |
| deficiency aspects, Glucose Intolerance (disease), Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We speculate that the rise in Type 2 diabetes in Indian urban populations may have been triggered by mild obesity in mothers, leading to glucose intolerance during pregnancy, macrosomic changes in the fetus, and insulin deficiency in adult life. | 9545123 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Pioglitazone (AD-4833) ameliorates insulin resistance in patients with NIDDM. | 9550126 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Both insulin resistance and abdominal fat patterning are related to aging, and have been related to cardiovascular disease (CVD) risk factors such as dyslipidemia and hypertension. | 9550536 |
| Inflammation, Thrombophilia, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Factor VII coagulant activity (VIIc) and hypercoagulability in chronic renal disease and dialysis: relationship with dyslipidaemia, inflammation, and factor VII genotype. | 9550647 |
| Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | A persistent inflammatory response and the dyslipidaemia of renal disease may contribute to coagulation activation and increased cardiovascular risk. | 9550647 |
| Increased insulin level | Deregulated Nutrient Sensing | These clinical features were compatible with leprechaunism; however, the absence of hyperinsulinemia and insulin resistance prevented the diagnosis of leprechaunism. | 9560023 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, analytical data point to a possible contribution of excessive hepatic glucose production to the pathogenesis of the insulin resistance in non-insulin-dependent diabetes mellitus. | 9560529 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance, dehydroepiandrosterone sulfate and sex hormone-binding globulin in essential hypertension. | 9566859 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology, Hypertensive (finding) | Deregulated Nutrient Sensing | In 15 non-treated hypertensive patients, insulin resistance was measured by an insulin suppression test (IST). | 9566859 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Disorders in lipid metabolism (dyslipidemia) can result to the chronic heart disease. | 9567502 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent, Kidney Diseases | Deregulated Nutrient Sensing | In type 2 diabetes, CAD is likely to be linked with the insulin resistance associated with the type 2 "process," while CAD in type 1 diabetes has, so far, been more closely linked to renal disease. | 9571351 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Because the etiologies of type 1 and type 2 diabetes are different, it is possible that some CAD in type 1 diabetes may be related to the coexistence of type 2 diabetes susceptibility (i.e., insulin resistance). | 9571351 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | This supports the concept that insulin resistance may contribute to development of CAD in type 1 diabetes. | 9571351 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Diabetes Mellitus, Non-Insulin-Dependent, Arteriopathic disease | Deregulated Nutrient Sensing | Improving dyslipidemia in type 2 diabetic subjects had no effect on the progress of ultrasonically measured arterial disease, although the lower rate of "definite CHD events" in the treated group suggests that this might result in a reduction in the incidence of coronary heart disease. | 9571357 |
| HD Term Type, Glucose Intolerance (disease), Hypertriglyceridemia, Hypoinsulinaemia (disorder) | Deregulated Nutrient Sensing | Thus, intravenous 1,25(OH)2D3 therapy corrected glucose intolerance, insulin resistance, hypoinsulinemia as well as hypertriglyceridemia in patients on HD, in the absence of PTH suppression. | 9573552 |
| Obesity | Deregulated Nutrient Sensing | Impaired stimulation of glucose metabolism and reduced suppression of lipolytic activity have both been suggested as important defects related to the insulin resistance of adolescent obesity. | 9575836 |
| Obesity | Deregulated Nutrient Sensing | Obesity type and clustering of insulin resistance-associated cardiovascular risk factors in middle-aged men and women. | 9578244 |
| Obesity | Deregulated Nutrient Sensing | To examine different clusterings of the insulin resistance-associated cardiovascular risk factors with respect to different types of obesity. | 9578244 |
| Hypertriglyceridemia, Hyperinsulinism, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The prevalence of a cluster consisting of dyslipidaemia (hypertriglyceridaemia and/or low HDL-cholesterol) and insulin resistance (abnormal glucose metabolism and/or hyperinsulinaemia) was found to be 4% in the control subjects, 18% in the abdominal adipose subjects (WHR > or = 1.00 in men and > or = 0.88 in women with a BMI < 30 kg/m2), 28% in the 'pure' obese subjects (BMI> or = 30 kg/m2 with WHR < 1.00 in men and < 0.88 in women), and 46% in the central obese subjects (subjects showing both 'pure' obesity and abdominal adiposity). | 9578244 |
| Obesity | Deregulated Nutrient Sensing | Clusterings of insulin resistance-associated abnormalities were related to the type of obesity in both middle-aged men and middle-aged women. | 9578244 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | There was no evidence of tachyphylaxis or evidence to suggest development of glucose intolerance. | 9578821 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that in transgenic mice expressing hIAPP, insulin resistance can induce overt, slow-onset diabetes associated with islet amyloid and decreased beta-cell mass. | 9588445 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | First-degree family history of diabetes may confer insulin resistance that is independent of obesity. | 9588451 |
| Microalbuminuria, Atherosclerosis | Deregulated Nutrient Sensing | Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study. | 9588452 |
| Microalbuminuria, Hyperglycemia, NEUROD1 wt Allele | Deregulated Nutrient Sensing | However, the relationship between insulin resistance and microalbuminuria in patients with NIDDM could be due to hyperglycemia, which can cause both insulin resistance and an increase in albumin excretion rate. | 9588452 |
| Microalbuminuria | Deregulated Nutrient Sensing | Little is known about microalbuminuria and insulin resistance in nondiabetic subjects. | 9588452 |
| Microalbuminuria, Obesity | Deregulated Nutrient Sensing | Our results suggest a relationship between insulin resistance and microalbuminuria in nondiabetic subjects that is partially dependent on blood pressure, glucose levels, and obesity. | 9588452 |
| Fatty Liver, Steatohepatitis | Deregulated Nutrient Sensing | We hypothesized that elevated GGT levels are a marker for visceral fat, and specifically for hepatic steatosis (fatty liver), and that hepatic steatosis leads to hepatic insulin resistance. | 9589232 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | A reduced capacity to deposit and/or conserve LBF may be an independent factor associated with (or may be a marker of) the metabolic manifestations of the insulin resistance syndrome in women with NIDDM. | 9589249 |
| AVP gene, Diabetes Mellitus | Deregulated Nutrient Sensing | Her case was complicated by non-insulin-dependent diabetes mellitus with severe insulin resistance, central diabetes insipidus, and hyposecretion of GH. | 9589656 |
| Hyperuricemia | Deregulated Nutrient Sensing | Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study. | 9590604 |
| Obesity, Abdominal, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR) has been linked to earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), insulin resistance, abdominal obesity, and an increased capacity to gain weight in some European and Japanese populations. | 9591756 |
| Disease | Deregulated Nutrient Sensing | Plasma ACE levels, but not ACE genotype, correlated with lipids, plasma glucose, and blood pressure, suggesting that elevated plasma ACE levels may contribute to the link between insulin resistance and CAD disease or may be a consequence of it. | 9591757 |
| Hypertension, CTCAE, Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance was higher in essential hypertension than in coronary heart disease. | 9594141 |
| Hypertension, CTCAE, Coronary heart disease | Deregulated Nutrient Sensing | It is suggested that the interaction between insulin resistance and angiotensin II and endothelins might be involved in the development of essential hypertension and coronary heart disease. | 9594141 |
| Diabetes Mellitus, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To evaluate whether a structural defect in the human glucose transporter gene GLUT1 could be involved in the aetiology of insulin resistance, a key factor of non-insulin-dependent diabetes mellitus (NIDDM) and obesity, we performed single-strand conformation polymorphism (SSCP) analysis in 40 subjects (20 NIDDM patients and 20 subjects with familial obesity). | 9600248 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes in Mexicans was high and it may be related to a genetic susceptibility for an insulin resistance syndrome. | 9608783 |
| Hyperglycemia | Deregulated Nutrient Sensing | Hyperglycaemia due to insulin resistance caused by interferon-gamma. | 9609368 |
| Hyperglycemia | Deregulated Nutrient Sensing | The injection of IFN-gamma may cause hyperglycaemia because of insulin resistance, rather than beta-cell injury. | 9609368 |
| Hypertensive (finding), Atherosclerosis, Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Of 5,284 residents studied from 1993 to 1994 the prevalence of risk factors of atherosclerosis such as obesity, disorders of lipid metabolism and glucose intolerance were higher in hypertensive who were normotensive due to antihypertensive drugs than in the non-hypertensive residents. | 9611991 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | Prevalences of type 2 diabetes, the insulin resistance syndrome, and coronary heart disease in an elderly, biethnic population. | 9614614 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To compare the prevalences of type 2 diabetes, the various cardiovascular risk factors encompassing the insulin resistance syndrome (IRS), and coronary heart disease (CHD) in elderly Hispanics compared with non-Hispanic whites. | 9614614 |
| Microalbuminuria, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Prevalences of total and central obesity, dyslipidemia, hypertension, and microalbuminuria also were determined. | 9614614 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The higher prevalences of dyslipidemia in Hispanics could be explained by a higher prevalence of diabetes. | 9614614 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest that PTH does not play a significant role in the dyslipidemia of renal failure. | 9617494 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Childhood obesity increases the risk of obesity in adulthood and is associated with cardiovascular disease (CVD) risk factors such as hypertension, diabetes mellitus, and dyslipidemia. | 9625086 |
| Cardiovascular morbidity, Diabetes Mellitus | Deregulated Nutrient Sensing | Markers of insulin resistance are associated with cardiovascular morbidity and predict overall mortality in long-standing non-insulin-dependent diabetes mellitus. | 9625290 |
| Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | These data indicate that in patients with long-standing type 2 diabetes mellitus and poor metabolic control, CHD and overall mortality are related to insulin release and to insulin administration, suggesting that markers of insulin resistance represent additional risk factors for CHD and for mortality. | 9625290 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Reduction of insulin resistance, together with achievement of good metabolic control, might prevent morbidity and mortality in long-standing type 2 diabetes mellitus. | 9625290 |
| Ovarian Hyperandrogenism | Deregulated Nutrient Sensing | Ovarian hyperandrogenism is associated with insulin resistance to both peripheral carbohydrate and whole-body protein metabolism in postpubertal young females: a metabolic study. | 9626116 |
| Obesity | Deregulated Nutrient Sensing | We conclude that obesity in young postpubertal females is associated with insulin resistance for both peripheral carbohydrate and protein metabolism, and that patients with the OH syndrome have even greater insulin resistance as compared with simple obesity, regardless of treatment for the androgen excess. | 9626116 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. | 9631870 |
| Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Because the changes were observed to be associated with insulin resistance and type 2 diabetes mellitus, they may be modifiable by reduction of insulin resistance with insulin sensitizers and stringent control of hyperglycemia. | 9631870 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The association of obesity and dyslipidemia, namely high triglycerides and low HDL-cholesterol levels, is well known, but, as far as we are aware, the possible influence of obesity on the efficacy of current hypolipidemic drugs has never been studied. | 9632956 |
| TG gene | Deregulated Nutrient Sensing | This simple assay for in vivo detection of LDL-LPO, emphasises the possible atherogenic effect of TG through their oxidative capacity and suggests the integration of LPO to the cluster of associated risk factors: high TG, low HDL-C and insulin resistance. | 9634641 |
| Increased insulin level | Deregulated Nutrient Sensing | As a result of this study, it seems reasonable to consider all obese children and adults as being at risk for hyperinsulinism and insulin resistance. | 9642626 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | However, NIDDM patients with the Tyr allele, which was previously reported to be associated with insulin resistance, tended to have lower BMIs than those without this allele (Asp/Asp: 24.5 +/- 1.1 kg/m2, Asp/Tyr: 22.6 +/- 0.4 kg/m2, Tyr/Tyr: 22.8 + 0.3 kg/m2, P = 0.06 by analysis of variance). | 9653600 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Stiffness indexes beta of the common carotid and femoral arteries are associated with insulin resistance in NIDDM. | 9653616 |
| FBN2 wt Allele, NEUROD1 wt Allele | Deregulated Nutrient Sensing | To investigate the association between arterial wall stiffness indexes beta of the common carotid artery (CCA) and the femoral artery (FA) and insulin resistance in NIDDM subjects in a cross-sectional study. | 9653616 |
| Arterial Stiffness, FBN2 wt Allele, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Arterial stiffness indexes beta of CCA and FA were associated with insulin resistance in NIDDM subjects. | 9653616 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Among these 36, 21 had coronary disease; the other 15 had, at least, another risk factor, besides dyslipidemia. | 9656510 |
| Non-compliance, Dyslipidemias | Deregulated Nutrient Sensing | [Factors involved in the non-compliance of the pharmacologic treatment of dyslipidemia]. | 9656579 |
| Left Ventricular Hypertrophy, Ventricular hypertrophy | Deregulated Nutrient Sensing | Left ventricular hypertrophy (LVH) has been associated with insulin resistance, a condition with an impaired insulin-mediated vasodilation in skeletal muscle. | 9657539 |
| Cardiovascular system | Deregulated Nutrient Sensing | This indicates that impaired peripheral blood flow (and thereby increased afterload) may be a possible mechanism explaining the previously found association between insulin resistance and cardiovascular hypertrophy. | 9657539 |
| Increased insulin level | Deregulated Nutrient Sensing | Our results suggest that the lowered glucose tolerance which follows gastrectomy results from disturbance of the hormonal relationship between pancreas and intestine (entero-insular axis), which causes increased intestinal glucose absorption, and the insulin resistance which occurs in response to hyperinsulinemia in patients with normal fasting plasma glucose. | 9659817 |
| Microalbuminuria, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study. | 9662052 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was defined as levels of HDL-cholesterol in the lowest and/or levels of triglyceride in the highest tertile. | 9662052 |
| Hyperinsulinism, Dyslipidemias | Deregulated Nutrient Sensing | No associations were found with impaired glucose tolerance, hyperinsulinaemia, IR or dyslipidaemia. | 9662052 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, immunoglobulin A, Cardiac Death | Deregulated Nutrient Sensing | Elevated levels of IgA, IgE, and IgG are associated with myocardial infarction and cardiac death in men with dyslipidemia. | 9665352 |
| Dyslipidemias, Coronary Thrombosis | Deregulated Nutrient Sensing | The present data suggest that, for dyslipidemia to cause coronary atherothrombosis, an immune response reflected by elevated levels of these immunoglobulin classes is an important determinant. | 9665352 |
| Increased insulin level | Deregulated Nutrient Sensing | Hematocrit and hemoglobin are independently related to insulin resistance and compensatory hyperinsulinemia in healthy, non-obese men and women. | 9667230 |
| Increased insulin level | Deregulated Nutrient Sensing | Thus, these results suggest that Hct and Hgb concentrations be added to the cluster of variables related to insulin resistance and compensatory hyperinsulinemia. | 9667230 |
| Weight Gain, Coronary Artery Disease | Deregulated Nutrient Sensing | The changes in lipid levels and blood pressure that occur with excessive weight gain with intensive therapy are similar to those seen in the insulin resistance syndrome and may increase the risk of coronary artery disease in this subset of subjects with time. | 9669786 |
| Immature, Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Epidemiological studies have suggested an association between glucose intolerance and hyperinsulinemia with premature CHD in Indian Asians. | 9672061 |
| Polycystic Ovary Syndrome, metabolic disturbance | Deregulated Nutrient Sensing | Metabolic disturbances associated with insulin resistance are present in most women with polycystic ovary syndrome. | 9674665 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | This association, if consistently present, could provide more evidence for a synergistic role for insulin resistance and altered fibrinolysis in the pathogenesis of CHD. | 9681596 |
| Diastolic blood pressure, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Diabetic and IGT subjects were older and had higher levels of BMI, triglyceride, systolic and diastolic blood pressure, and higher prevalence of obesity, hypertension, and dyslipidemia but indulged in less physical activity than non-diabetic subjects. | 9686696 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Furthermore, these findings support the hypothesis that cardiovascular disease risk commences with rising glucose concentrations before 'conventionally-defined' glucose intolerance occurs. | 9686697 |
| Tumor necrosis | Deregulated Nutrient Sensing | Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha. | 9688632 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We report a study of 10 candidate genes presumably involved in diabetes or insulin resistance or obesity among Pondicherian Tamil Indians, an isolated population with a high prevalence of diabetes. | 9690058 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Our data demonstrate an increased platelet adhesion and aggregation in diabetic patients and suggest a modulatory role of diabetic dyslipidemia. | 9692617 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension and insulin resistance in a native unindustrialised rural population of India. | 9699937 |
| Glucose Intolerance (disease), Atherosclerosis | Deregulated Nutrient Sensing | Ultrasonographic manifestations of carotid atherosclerosis and glucose intolerance in elderly eastern Finnish men. | 9702446 |
| Hypertensive (finding), Hyperinsulinism | Deregulated Nutrient Sensing | Hyperinsulinaemia in hypertensive subjects: validity of a test for the detection of insulin resistance in clinical practice. | 9702932 |
| Hypertensive (finding), Hyperinsulinism | Deregulated Nutrient Sensing | To determine the prevalence of hyperinsulinaemia in non-diabetic hypertensive subjects and to investigate the validity of a simple test for the detection of insulin resistance/hyperinsulinaemia. | 9702932 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | Our results suggest that hyperinsulinaemia/insulin resistance in hypertensives becomes identifiable by using simple measurements of BMI, WHR, serum triglycerides and HDL cholesterol as well as the oral glucose tolerance test as means. | 9702932 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance in essential hypertension is related to plasma renin activity. | 9705039 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | In conclusion, the present investigation showed that insulin resistance is associated with elevated levels of PRA in patients with untreated essential hypertension. | 9705039 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Agents that ameliorate insulin resistance and reduce circulating insulin levels could provide a new therapeutic modality for PCOS. | 9709933 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | We conclude that a fasting G:I ratio may be useful as a screening test for insulin resistance in obese non-Hispanic white PCOS women. | 9709933 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | obesity, type 2 diabetes mellitus, dyslipidemia, or hypertension) were detected. | 9709965 |
| No metabolic abnormalities, Diabetes Mellitus | Deregulated Nutrient Sensing | The finding of an association between high plasma levels of TNF-alpha and several metabolic abnormalities characteristic for the insulin resistance syndrome suggests that TNF-alpha may be involved in the pathogenesis of non-insulin-dependent diabetes mellitus. | 9714125 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate the number of people with intolerance to glucose (ITG) and undiagnosed diabetes (DM) among primary care users at risk. | 9717347 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | [The selective detection of glucose intolerance and diabetes in primary care. | 9717347 |
| Muscle damage, pancreatic juice | Deregulated Nutrient Sensing | Eccentric exercise (ECC) causes muscle damage, insulin resistance, and increased pancreatic beta-cell secretion in young individuals. | 9725813 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Deteriorated insulin resistance was described in patients with essential hypertension. | 9727207 |
| Conn Syndrome, Hypertension, CTCAE | Deregulated Nutrient Sensing | The objective of the present study was to test at the receptor and postreceptor level the presence of insulin resistance in hypertension with primary hyperaldosteronism. | 9727207 |
| Conn Syndrome | Deregulated Nutrient Sensing | It may be stated that primary hyperaldosteronism is associated with insulin resistance at the postreceptor level. | 9727207 |
| Renal Insufficiency, Communicable Diseases, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The overall rates of infection, impaired renal function (31.5% vs 21.4%), and glucose intolerance (7.0% vs 4.3%) did not differ significantly between the tacrolimus and cyclosporine treatment groups. | 9730426 |
| Dyslipidemias, Shock, Cardiogenic | Deregulated Nutrient Sensing | On multivariate analysis, cardiogenic shock on admission and absence of dyslipidemia were strong and independent predictors (p = 0.01) of IRA reocclusion. | 9732878 |
| Osteoporosis, Vascular calcification, Ulcer, Cataract, Glucose Intolerance (disease), Werner Syndrome, Hypogonadism | Deregulated Nutrient Sensing | Werner's syndrome associates early aging in young adults, small height, cataract, glucose intolerance, hypogonadism, skin ulcers, vascular calcifications and osteoporosis. | 9747202 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias, Hyperglycemia, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Moreover, the presence and importance of abnormalities such as high low-density lipoprotein (LDL) cholesterol and triglycerides levels as CHD risk factors in insulin-dependent diabetes mellitus type 1 have been downplayed, while increasing evidence suggests that the management of type 1 patients should include control of dyslipidemia and hyperglycemia and an effective antihypertensive treatment able also to reduce risk factors for coronary artery events. | 9747962 |
| Obesity | Deregulated Nutrient Sensing | Similarly, biochemical parameters considered as general markers of insulin resistance (often associated with obesity) did not correlate significantly with leptinemia. | 9750462 |
| Increased insulin level | Deregulated Nutrient Sensing | The symptoms develop on the background of insulin resistance and are associated with hyperinsulinism. | 9750464 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. | 9752890 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. | 9752890 |
| Obesity | Deregulated Nutrient Sensing | These data indicate that obesity decreases glucose tolerance by way of progressively increased insulin resistance and, in the case of prolonged duration, by decreased insulin secretion as well. | 9753008 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. | 9753305 |
| Metabolic Diseases | Deregulated Nutrient Sensing | The prevalence of insulin resistance in the most common metabolic disorders is still an undefined issue. | 9753305 |
| Hypercholesterolemia, Hypertension, CTCAE, Hyperuricemia | Deregulated Nutrient Sensing | In isolated hypercholesterolemia, hypertension, or hyperuricemia, prevalence rates of insulin resistance were not higher than that in nonobese normal subjects. | 9753305 |
| Hyperuricemia, Dyslipidemias, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | An appreciable number of subjects (n = 85, 9.6% of the whole population) was insulin resistant but free of IGT, NIDDM, dyslipidemia, hyperuricemia, and hypertension. | 9753305 |
| Hyperglycemia, Saint Lucia | Deregulated Nutrient Sensing | BCAAs solution causes hyperglycemia in mild LC due to insulin resistance, whereas it causes only a slight increase in severe LC due to hepatic glucagon resistance. | 9754734 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | There was a gradual decrease in mean height (cm) as glucose intolerance became more severe: N: 161.0 +/- 6.2, OAV:160.2 +/- 6.1, GDM:158.7 +/- 6.3, Type II diabetes 158.2 +/- 7.0 (p < 0.001, analysis of variance]. | 9754816 |
| Dyslipidemias | Deregulated Nutrient Sensing | The presence of small LDL particles appears to be an early and unexplained feature of the uraemic dyslipidaemia. | 9761510 |
| Dysfunctional ventilatory weaning response | Deregulated Nutrient Sensing | Insulin resistance may contribute to the previously unexplained association between ventilatory function impairment and cardiovascular mortality. | 9762792 |
| Dysfunctional ventilatory weaning response, Coronary heart disease | Deregulated Nutrient Sensing | These findings are consistent with the possibility that insulin resistance may be one of the factors mediating the previously unexplained prospective association between impairment of ventilatory function and risk of mortality from coronary heart disease. | 9762793 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Additional adjustment for baseline postcarbohydrate challenge glucose levels made little difference to the results, suggesting that baseline glucose intolerance was not a significant source of bias. | 9762793 |
| Hyperlipidemia, USF1 wt Allele | Deregulated Nutrient Sensing | Familial combined hyperlipidemia (FCHL) is characterized by hyperlipidemia and insulin resistance, but intracellular defect in insulin action is unknown. | 9763525 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia? | 9763525 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | In FCHL family members without dyslipidemia and in control subjects, FFAs during the clamp correlated positively with levels of total triglycerides (P<0.001) and very low density lipoprotein cholesterol (P=0.008). | 9763525 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | We conclude that in patients with FCHL, and also in their first-degree relatives, insulin's suppressive effect on FFA levels is impaired, which may precede dyslipidemia in FCHL. | 9763525 |
| Adrenarche | Deregulated Nutrient Sensing | Recently, pronounced adrenarche and insulin resistance have each been related to low birth weight. | 9768664 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The relationship between insulin resistance and abnormality of cellular calcium metabolism in patients with essential hypertension. | 9772426 |
| Weight Gain | Deregulated Nutrient Sensing | Weight gain and the risk of developing insulin resistance syndrome. | 9773723 |
| Weight Gain | Deregulated Nutrient Sensing | Moreover, there was a strong graded association between categories of weight gain and risk of insulin resistance syndrome. | 9773723 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | In this study both sets of criteria diagnosed a similar number of diabetic subjects, but many of the subjects shifted between glucose intolerance categories. | 9773731 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | The abnormalities of glucose metabolism in nondippers could be explained by insulin resistance and beta-cell dysfunction. | 9773741 |
| Hypertensive (finding), Hypertension, CTCAE, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The goals of this study were to compare glucose tolerance in dipper and nondipper hypertensive patients and to explore the cause of glucose intolerance in essential hypertension. | 9773741 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The dyslipidemia of chronic renal failure may worsen after the commencement of continuous ambulatory peritoneal dialysis (CAPD). | 9773795 |
| Hyperglycemia, Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | Weight loss can therefore, at least in the short term, act to decrease the risk of developing diabetes by reducing insulin resistance, and thus relieving beta-cell stress, the factor ultimately responsible for hyperglycaemia in predisposed individuals. | 9777320 |
| Atherosclerosis | Deregulated Nutrient Sensing | Relationships between insulin resistance and lipoproteins in nondiabetic African Americans, Hispanics, and non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. | 9781617 |
| Atherosclerosis | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study (IRAS) is a multicenter epidemiologic study conducted at four clinical centers in California, Texas, and Colorado. | 9781617 |
| Overweight | Deregulated Nutrient Sensing | ACE inhibition but not angiotensin II antagonism reduces plasma fibrinogen and insulin resistance in overweight hypertensive patients. | 9781930 |
| Hypertensive disease | Deregulated Nutrient Sensing | These findings suggest that insulin resistance may play a role in the pathogenesis of the hypertensive disorders of pregnancy. | 9790393 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | We studied an extended pedigree in which multiple members are affected by late-onset NIDDM associated with insulin resistance and performed linkage analysis with four microsatellite markers in the MODY3 region of chromosome 12q. | 9792550 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | These results confirm that the association between reduced fetal growth and glucose intolerance is mediated through insulin resistance and depends upon an interaction with obesity in adult life. | 9794098 |
| Glucose Intolerance (disease), Failure (biologic function) | Deregulated Nutrient Sensing | Failure to stratify by gestational age in previous studies could account for inconsistencies in the relations of insulin resistance and glucose intolerance to size at birth and for the detection of stronger associations with ponderal index than with birthweight. | 9794098 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | After adjusting for adult body mass index, prevalence of glucose intolerance (defined as diabetes or impaired glucose tolerance) was inversely related to birthweight. | 9794098 |
| Adenoma, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance and adenomas of the sigmoid colon in Japanese men (Japan). | 9794177 |
| Metabolic Diseases, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | The association of clusters of risk factors and their relations with coronary heart disease provide important clues that may be used in understanding the metabolic disorders associated with insulin resistance and diabetes. | 9801017 |
| Blood Glucose, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Other vascular risk factors able to influence fibrinolytic parameters such as glycemia, obesity, hypertension, dyslipidemia, and oxidative stress were also considered. | 9801931 |
| Atherosclerosis | Deregulated Nutrient Sensing | A cross-sectional analysis was conducted among 623 postmenopausal women in the Insulin Resistance Atherosclerosis Study (IRAS). | 9802722 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study. | 9802726 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The frequencies of dyslipidemia and nonlipid risk factors in patients with and without CHD were determined and compared. | 9810294 |
| Glucose Intolerance (disease), Peripheral Arterial Diseases | Deregulated Nutrient Sensing | Glucose intolerance, physical signs of peripheral artery disease, and risk of cardiovascular events: the Framingham Study. | 9812089 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance was associated with a 2-fold excess occurrence of physical signs of PAD (P< .01 ). | 9812089 |
| Glucose Intolerance (disease), Choline Dehydrogenase, Mitochondrial, Cerebrovascular accident, Congestive heart failure | Deregulated Nutrient Sensing | Femoral and carotid bruits were generally associated with greater increased risk of CHD, CHF, and CVA than was glucose intolerance alone. | 9812089 |
| Glucose Intolerance (disease), Bruit | Deregulated Nutrient Sensing | Particularly in women, the concomitant presence of bruits augmented the CVD risk of glucose intolerance. | 9812089 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Physical findings of PAD appear to signify a compromised arterial circulation to the heart and brain as well as the limbs in persons with glucose intolerance. | 9812089 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To elucidate the role of hypertension as part of a state of insulin resistance. | 9816552 |
| Microalbuminuria, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Hypertrophy | Deregulated Nutrient Sensing | insulin resistance, on renal function with microalbuminuria, changes of some echocardiographic signs of hypertrophy and compliance of the left ventricle in patients with hypertension and type II diabetes mellitus. | 9820056 |
| Microalbuminuria, Natriuresis | Deregulated Nutrient Sensing | In addition to the anticipated drop of blood pressure a declining trend of insulin resistance was recorded, there was a significant decline of microalbuminuria and a rise of natriuresis, the left ventricle mass declined and its compliance improved. | 9820056 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Ageing is one of the major risk factors for glucose intolerance including impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. | 9833938 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Smaller LDL particles are associated with an increased risk for coronary artery disease and have been found predominantly in subjects with the insulin resistance syndrome. | 9839097 |
| metabolic disturbance | Deregulated Nutrient Sensing | Although insulin resistance has been suggested to be a basic defect, little is known about the relation between this predisposing factor (and associated metabolic disturbances) and LDL size distribution in young and metabolically healthy subjects. | 9839097 |
| Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | Dyslipidaemia (any one of low-HDL-cholesterol, high triglyceride or high cholesterol) was common in both normotensives and hypertensives (40.5% vs 46.4%). | 9844943 |
| Hyperglycemia, Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | Hypertensives showed significantly higher levels of total cholesterol, triglyceride, blood glucose, urate and more clustering of hyperglycaemia and dyslipidaemia than normotensives even after adjustment for BMI. | 9844943 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Abdominal visceral fat (AVF) is an obesity-related phenotype thought to be associated with insulin resistance, diabetes mellitus, and atherosclerosis. | 9851757 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Current zinc intake and risk of diabetes and coronary artery disease and factors associated with insulin resistance in rural and urban populations of North India. | 9853535 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the association between current zinc intake and prevalence of coronary artery disease (CAD) and diabetes as well as factors associated with insulin resistance. | 9853535 |
| Hypertriglyceridemia, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Lower consumption of dietary zinc and low serum zinc levels were associated with an increased prevalence of CAD and diabetes and several of their associated risk factors including hypertension, hypertriglyceridemia and other factors suggestive of mild insulin resistance in urban subjects. | 9853535 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of CAD, diabetes and glucose intolerance was significantly higher among subjects consuming lower intakes of dietary zinc. | 9853535 |
| Non-insulin Hypoglycemic, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | [Relationship between medical treatment compliance and the degree of control in patients with high blood pressure, non-insulin dependent diabetes mellitus and dyslipidemia]. | 9859088 |
| Diabetes Mellitus, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Association of central obesity and insulin resistance with high prevalence of diabetes and cardiovascular disease in an elderly population with low fat intake and lower than normal prevalence of obesity: the Indian paradox. | 9861517 |
| Cardiovascular Diseases, Diabetes Mellitus, Insulin resistance syndrome | Deregulated Nutrient Sensing | To test the hypothesis that high prevalences of cardiovascular disease and diabetes in urban population of India are manifestations of insulin-resistance syndrome. | 9861517 |
| Dyslipidemias, Obesity, Abdominal, Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | Impaired lipolysis has been proposed as a pathogenic factor contributing to clustering of abdominal obesity and dyslipidaemia in Type II (non-insulin-dependent) diabetes mellitus--that is, the metabolic syndrome (MSDR). | 9867220 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The association between insulin resistance and coronary heart disease (CHD) is strong in the British Indian-Asian population. | 9868972 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Adipocyte metabolism may contribute to both insulin resistance and CHD. | 9868972 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | It is concluded that glucose intolerance and central obesity are common in this region of Uzbekistan, about which there was previously little information. | 9868981 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To determine whether kinetic abnormalities in the onset of insulin action contribute to the insulin resistance in obesity-associated hypertension. | 9869012 |
| Dyslipidemias | Deregulated Nutrient Sensing | Fibrinolytic potential is significantly increased by oestrogen treatment in postmenopausal women with mild dyslipidaemia. | 9875081 |
| Dyslipidemias | Deregulated Nutrient Sensing | Hormone replacement treatment with 17 beta-oestradiol for nine weeks significantly increased fibrinolytic potential in postmenopausal women with mild dyslipidaemia. | 9875081 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. | 9876070 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The mechanism of insulin resistance in patients with cancer is not clear. | 9876070 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | These results may suggest that IL-6 is related to insulin resistance in patients with cancer. | 9876070 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The studied factors manifesting an increase in risk for the development of GSD were age (P<0.05), high body mass index (P< 0.05), diabetes mellitus (adjusted odds ratio: 1.998; P< 0.05) and glucose intolerance (adjusted odds ratio: 2.056; P<0.05) by multivariate analysis. | 9883999 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Age, high body mass index, diabetes mellitus and glucose intolerance are the risk factors for developing GSD in Taiwan. | 9883999 |
| Diastolic blood pressure | Deregulated Nutrient Sensing | In addition, simple linear regressions revealed that both systolic and diastolic blood pressure correlated significantly with serum leptin and the insulin resistance index in both groups. | 9886890 |
| Microalbuminuria | Deregulated Nutrient Sensing | The O'Sullivan test, on its own or with the microalbuminuria test, seems very useful for identifying obese subjects with resistance to insulin. | 9887576 |
| Electrocardiogram: myocardial infarction (finding), Coronary Artery Disease, Atherosclerosis | Deregulated Nutrient Sensing | Polymorphisms of angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) genes have been reported to be associated with myocardial infarction and coronary artery disease, both of which are closely related to atherosclerosis and insulin resistance. | 9893168 |
| Cell secretion, Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Women with polycystic ovary syndrome (PCOS) are insulin resistant, have insulin secretory defects, and are at high risk for glucose intolerance. | 9920077 |
| Glucose Intolerance (disease), Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | We performed this study to determine the prevalence of glucose intolerance and parameters associated with risk for this in PCOS women. | 9920077 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of glucose intolerance was 31.1% impaired glucose intolerance (IGT) and 7.5% diabetes. | 9920077 |
| Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that 1) PCOS women are at significantly increased risk for IGT and type 2 diabetes mellitus at all weights and at a young age; 2) these prevalence rates are similar in 2 different populations of PCOS women, suggesting that PCOS may be a more important risk factor than ethnicity or race for glucose intolerance in young women; and 3) the American Diabetes Association diabetes diagnostic criteria failed to detect a significant number of PCOS women with diabetes by postchallenge glucose values. | 9920077 |
| Tumor necrosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Recent research suggests that tumor necrosis factor-alpha (TNF alpha) may play an important role in obesity-associated insulin resistance and diabetes. | 9920095 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | We studied the relationship between TNF alpha and the anthropometric and physiological variables associated with insulin resistance and diabetes in an isolated Native Canadian population with very high rates of type 2 diabetes mellitus (DM). | 9920095 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | If confirmed, these data suggest new opportunities for research that include exploring a possible role for carotenoids in the pathogenesis of insulin resistance and diabetes. | 9921962 |
| Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The role of tumor necrosis factor-alpha in insulin resistance has been studied in 59 patients with Type 2 diabetes, 28 with android type obesity and 35 healthy lean controls. | 9925347 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | According to these data the cytokine might play a role in insulin resistance in obesity as well in Type 2 diabetes. | 9925347 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The total amount of time spent on physical activity decreased with increasing glucose intolerance. | 9927216 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The etiology of non-insulin-dependent diabetes mellitus (NIDDM) is usually explained as a combination of peripheral insulin resistance and impaired beta-cell function. | 9930938 |
| CDISC SDTM Immunogenicity Specimen Assessments Test Name Terminology | Deregulated Nutrient Sensing | The IST showed marked insulin resistance in both parents and the older son, and moderate resistance in the younger son, previously not described. | 9930938 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | PFK1-M-deficiency leads to a metabolic state typical for early NIDDM in homozygously affected humans, especially concerning insulin resistance and loss of first phase beta-cell insulin secretion, and may contribute to the manifestation of NIDDM in a subgroup of patients. | 9930938 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Most patients with cirrhosis of the liver have detectable insulin resistance. | 9930950 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Based on the fact that his urinary C-peptide levels increased, the diabetes mellitus may have been due to insulin resistance with obesity. | 9932637 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Leptin, important for body weight regulation, may be involved in the pathogenesis of the insulin resistance syndrome, associated with cardiovascular disease. | 9933268 |
| Increased insulin level, Hyperparathyroidism | Deregulated Nutrient Sensing | Disturbances of glucose metabolism with hyperinsulinism and peripheral insulin resistance are frequently observed in patients with hyperparathyroidism. | 10025037 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | These data show that serum C3 correlates with a cluster of conventional risk factors for myocardial infarction resembling insulin resistance. | 10063429 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance was identified from the blood glucose level, HbA1c level and history of diabetes mellitus. | 10064971 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The results suggest that the prevalence of glucose intolerance depends on the environment in which people live. | 10064971 |
| Cardiovascular Diseases, Atherosclerosis | Deregulated Nutrient Sensing | MS alone and clusters of AP, AO, and HLP characterized by insulin resistance, accelerate the development of cardiovascular diseases associated with atherosclerosis. | 10067244 |
| TG gene, Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia in the presence of MS and in combinations of AP with AO and HLP was characterized by increased levels of TG and total CS and decreased content of CS and high-density lipoproteins, which was associated with basal hyperinsulinemia. | 10067244 |
| Hypertension, CTCAE, Coronary Arteriosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Non-insulin-dependent diabetes, hypertension and ischaemic heart disease, with insulin resistance, are associated with low birth weight (the 'Small Baby Syndrome'). | 10070502 |
| Increased insulin level, Glucose Intolerance (disease), Depressed mood, Atherosclerosis | Deregulated Nutrient Sensing | Decreased fibrinolysis in the presence of subclinical disease in subjects with hyperinsulinemia or glucose intolerance is consistent with the premise that depressed plasmin generation may enhance the progression of atherosclerosis in these people. | 10073949 |
| Microalbuminuria, Hypertension, CTCAE | Deregulated Nutrient Sensing | Therefore, it is suspected that microalbuminuria is a renal facet of insulin resistance, and a predictor value of hypertension. | 10075379 |
| Apolipoprotein E, Cholelithiasis, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The role of apolipoprotein E and glucose intolerance in gallstone disease in middle aged subjects. | 10075965 |
| Hyperleucinemia, Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | To determine if fat deposition within mid-thigh muscle, represented by low density lean tissue density, is associated with age, low physical fitness, hyperleptinemia, hyperinsulinemia and dyslipidemia in women. | 10078845 |
| CD55 gene, Hypertriglyceridemia | Deregulated Nutrient Sensing | Insulin resistance is associated with hypertriglyceridemia, low serum high-density lipoprotein cholesterol (HDL-C) concentrations and high serum total cholesterol (TC) to HDL-C ratios. | 10083765 |
| Obesity | Deregulated Nutrient Sensing | This reduction in 11betaHSD1 activity raises new questions as to the primary role of 11betaHSD1 in the pathogenesis of insulin resistance and central obesity. | 10084590 |
| Thalassemia | Deregulated Nutrient Sensing | Moreover non-diabetic thalassaemic patients showed a clear reduction of both beta-cell function and insulin resistance indices (HOMA model). | 10091158 |
| Glucose Intolerance (disease), Primary Hypothyroidism, Thalassemia | Deregulated Nutrient Sensing | Glucose intolerance and primary hypothyroidism were less frequent (24 and 5.7%, respectively) and milder than in thalassaemia major patients. | 10091174 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | Glucose tolerance and insulin-resistance syndrome among St. Lawrence Island Eskimos. | 10093304 |
| NEUROD1 wt Allele, Insulin resistance syndrome | Deregulated Nutrient Sensing | Although NIDDM prevalence was not high compared to non-Native U.S. residents, elements of the insulin-resistance syndrome exist in this subarctic population. | 10093304 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The transition in glucose intolerance from Cameroon to Jamaica and Britain suggests that environment determines diabetes prevalence in these populations of similar genetic origin. | 10097925 |
| Inflammatory Bowel Diseases | Deregulated Nutrient Sensing | Moreover, glucocorticoids, which are widely used in the treatment of inflammatory bowel disease, are notoriously related to insulin resistance. | 10102952 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with diabetes, hypertension, and heart disease reported lower predicted VO2max than their healthier counterparts (p < .0001), but this was not the case for dyslipidemia subjects (27.6 +/- 7.6 vs. 27.4 +/- 8.2 ml/kg/min, respectively; p > .58). | 10181139 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A larger proportion of diseased subjects was in the lowest fitness quintile for diabetes, hypertension, and heart disease, but not for dyslipidemia. | 10181139 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The prevalence of hyperinsulinemia/insulin resistance in hypertensive individuals, as well as the effects of insulin on myocytic and fibroblastic growth, are well known in both epidemiologic and animal models. | 10192231 |
| Hypertensive (finding), Central visual impairment | Deregulated Nutrient Sensing | Hyperinsulinemia/insulin resistance could cause an altered collagen/muscular ratio, which could potentially explain, at least in part, the CVI alterations detected in hypertensive patients. | 10192231 |
| Angina Pectoris | Deregulated Nutrient Sensing | Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with angina pectoris. | 10192232 |
| Angina Pectoris | Deregulated Nutrient Sensing | In conclusion, the D allele was not associated with higher insulin resistance in patients with angina pectoris; that is, patients with the ID and DD genotypes were associated with a significantly lower risk of insulin resistance, compared to those with the II genotype. | 10192232 |
| Endothelial dysfunction, Obesity | Deregulated Nutrient Sensing | C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? | 10195925 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | We have also related levels of C-reactive protein and interleukin-6 to markers of the insulin resistance syndrome and of endothelial dysfunction. | 10195925 |
| Endothelial dysfunction, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Moreover, our data support the concept that such a low-level, chronic inflammatory state may induce insulin resistance and endothelial dysfunction and thus link the latter phenomena with obesity and cardiovascular disease. | 10195925 |
| Weight Gain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Recently, a mutation in the beta 3AR gene (Trp64Arg) has been reported to be associated with features of insulin resistance, weight gain and early onset of Type 2 Diabetes Mellitus. | 10197086 |
| Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance syndrome has recently been described as a unifying hypothesis to explain the relationship between the many risk factors of coronary heart disease. | 10198911 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Both defective insulin secretion and insulin resistance have been reported in relatives of type 2 diabetic subjects. | 10199785 |
| Hyperlipidemia, Premature coronary artery atherosclerosis, Dyslipidemias, USF1 wt Allele, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Familial combined hyperlipidemia (FCHL) is a common dyslipidemia predisposing to premature coronary heart disease (CHD). | 10205279 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Since the therapeutic dose of nicorandil did not affect pancreatic B-cell function but caused insulin resistance in both healthy and NIDDM subjects, we conclude that K-ATP channels play a regulatory role in insulin-mediated glucose transport in humans. | 10206433 |
| Disease | Deregulated Nutrient Sensing | Insulin resistance and human disease: a short history. | 10212844 |
| Dyslipidemias, Vascular System Injuries | Deregulated Nutrient Sensing | Nearly all patients present with dyslipidemia, a prominent vascular risk factor, probably responsible for the high rate of vascular injury. | 10215333 |
| Hypertriglyceridemia, Obesity | Deregulated Nutrient Sensing | Multivariate analysis indicated that older age and high level of low-density-lipoprotein cholesterol corresponded to an elevated Lp(a) level, while hypertriglyceridemia, low high-density-lipoprotein cholesterol level, obesity and high insulin resistance corresponded to a lower Lp(a) level. | 10217355 |
| Hypertriglyceridemia, metabolic disturbance | Deregulated Nutrient Sensing | While hypertriglyceridaemia may exert an influence independent of other lipid factors, insulin resistance is probably the underlying metabolic disturbance. | 10217356 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Clinico-hemodynamic parameters, lipid blood spectrum and plasmic hemostasis were studied in 28 elderly CHD patients divided into groups by dyslipidemia type (IIA, IIB, IV). | 10222562 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The proposed balanced antiatherogenic vegetarian diet proved to be an effective monotherapy of dyslipidemia in elderly patients with coronary heart disease. | 10222562 |
| Glucose Intolerance (disease), Pancreatic carcinoma | Deregulated Nutrient Sensing | The mechanisms responsible for glucose intolerance in patients with pancreatic cancer remain controversial. | 10228759 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | The authors compared the abilities of descriptive and valuational health-related quality-of-life measures to discriminate healthy participants (n=39) from those on diets for dyslipidemia (n=35) and angina patients (n=30). | 10231077 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | On the rating scale, the time tradeoff, and the General Health Perception subscale of the SF-36 Health Survey, the participants with dyslipidemia or angina reported lower mean scores than the healthy participants. | 10231077 |
| Congestive heart failure | Deregulated Nutrient Sensing | Previous studies have demonstrated that insulin resistance is a common feature of congestive heart failure (CHF), but the clinical significance of such insulin resistance is still debated. | 10235092 |
| Acromegaly | Deregulated Nutrient Sensing | Insulin-mediated pseudoacromegaly in a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired phosphatidylinositol 3-kinase activity in fibroblasts. | 10320056 |
| Acanthosis Nigricans, Obesity, Hypothyroidism | Deregulated Nutrient Sensing | Acanthosis nigricans with severe obesity, insulin resistance and hypothyroidism: improvement by diet control. | 10325466 |
| Acanthosis Nigricans, Obesity, Hypothyroidism | Deregulated Nutrient Sensing | We report on a 27-year-old man with acanthosis nigricans (AN) associated with severe obesity, insulin resistance and hypothyroidism. | 10325466 |
| Hypothyroidism | Deregulated Nutrient Sensing | This confirms that AN may be mainly attributed to insulin resistance rather than hypothyroidism per se. | 10325466 |
| Weight Gain | Deregulated Nutrient Sensing | Weight gain and insulin resistance during nicotine replacement therapy. | 10326169 |
| Weight Gain, Myocardial Ischemia, Coronary heart disease | Deregulated Nutrient Sensing | Although the cessation of smoking reduces the increased risk for ischemic heart disease, it is associated with marked weight gain and presumably insulin resistance, both of which heighten the risk of coronary heart disease. | 10326169 |
| Weight Gain | Deregulated Nutrient Sensing | Smoking cessation is associated with weight gain and improvement in insulin resistance. | 10326169 |
| Weight Gain | Deregulated Nutrient Sensing | Nicotine is the main ingredient in cigarette smoke causing insulin resistance, but the withdrawal of another, unknown ingredient in cigarette smoke is responsible for the weight gain associated with smoking cessation. | 10326169 |
| Autoimmune Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is not an autoimmune disease but rather results from both insulin resistance and a nonautoimmune insulin secretory defect. | 10331401 |
| TG gene, Obesity | Deregulated Nutrient Sensing | If fasting TG was <1.7 mmol/l (isolated low HDL cholesterol), individuals were similar to the general population in terms of insulin resistance and obesity. | 10331414 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | The higher prevalence of isolated low HDL cholesterol, the young age at which individuals exhibit this phenotype (mean age 32.5 years), along with the greater propensity for Asian Indians to develop insulin resistance and IGT contribute to the threefold increased incidence of myocardial infarction in those <65 years of age in this ethnic group. | 10331414 |
| diabetic | Deregulated Nutrient Sensing | Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. | 10332688 |
| diabetic | Deregulated Nutrient Sensing | The 80 subjects, selected because they had not received insulin therapy, were among 111 diabetic participants in a clamp study for evaluation of insulin resistance from May 1993 to December 1997 in Osaka City University Hospital. | 10332688 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Kidney Diseases | Deregulated Nutrient Sensing | Furthermore, there was an excess of risk factors for development of Type II diabetes (higher fasting plasma glucose concentrations, higher prevalence of hypertension, higher waist-hip ratio and a tendency towards more glucose intolerance) among previously non-diabetic parents of patients with nephropathy. | 10333042 |
| Autoimmune Diseases, Obesity, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | This observation together with the association between GAD65 autoantibody concentrations and body mass index indicate a possible relation between islet autoimmunity and beta-cell function abnormalities with obesity and insulin resistance. | 10333047 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Role of insulin resistance in the genesis of sodium sensitivity in essential hypertension. | 10333344 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These results showed that insulin resistance might participate in the genesis of sodium sensitivity in essential hypertension by enhancing tubular sodium reabsorption, as reflected in decreased FE(Na) and augmented creatinine clearance. | 10333344 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance seemed elevated in sodium sensitive state of essential hypertension, leading to future cardiovascular events. | 10333344 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The increased cardiovascular risk in subjects with NIDDM is partly explained by an association with established risk factors like hypertension, dyslipidemia, and obesity. | 10333913 |
| Hyperhomocysteinemia, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hyperhomocysteinemia did not cluster with other cardiovascular risk factors, like hypertension, obesity, or dyslipidemia. | 10333913 |
| Maturity Onset Diabetes of the Young Pathway, Diabetes mellitus autosomal dominant type II (disorder), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our findings indicate the existence of forms of early-onset autosomal-dominant type 2 diabetes that are distinct from MODY and are frequently characterized by insulin resistance, similar to later-onset type 2 diabetes. | 10333942 |
| Hyperglycemia, Dyslipidemias, Pathologic Intimal Thickening, Diabetes Mellitus | Deregulated Nutrient Sensing | Our data suggest that hyperglycemia, together with a clustering of risk factors, and in particular dyslipidemia, may cause intimal-medial thickening in the early phases of diabetes. | 10333954 |
| Obesity | Deregulated Nutrient Sensing | Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects. | 10337870 |
| Obesity | Deregulated Nutrient Sensing | An alanine to threonine substitution at codon 54 of the fatty acid binding protein 2 (FABP2) gene has been associated with insulin resistance in Pima Indians and with obesity in aboriginal Canadians. | 10337870 |
| Obesity | Deregulated Nutrient Sensing | These results suggest that the polymorphism at codon 54 of the FABP2 gene is not a major contributing factor to obesity and insulin resistance in Japanese subjects. | 10337870 |
| Tumor necrosis, Obesity | Deregulated Nutrient Sensing | Recently an important role of the cytokine tumor necrosis factor-alpha in mediating insulin resistance of obesity through its overexpression in fat tissue has been reported. | 10340439 |
| Obesity | Deregulated Nutrient Sensing | In order to examine the relation of insulin resistance to obesity and to serum neopterin, as a parameter of immune activation, we studied 1234 otherwise healthy outpatients, who visited the physician's office for a medical health check-up. | 10340439 |
| Tumor necrosis | Deregulated Nutrient Sensing | The data may indicate that moderate immune stimulation plays a role in the development of insulin resistance, and an influence of tumor necrosis factor-alpha seems to be probable. | 10340439 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus. | 10342336 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (DM) develops when insulin resistance overcomes the capacity of compensatory insulin secretion. | 10342336 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | A polymorphism of the glucocorticoid receptor gene, with 13.7% homozygotes in the male Swedish population, parallels receptor dysfunction, and may be responsible for the associated insulin resistance, central obesity and hypertension. | 10342336 |
| No endocrine abnormalities, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The results suggest that an hypothalamic arousal syndrome, with parallel activation of the HPA axis and the central sympathetic nervous system, is responsible for development of endocrine abnormalities, insulin resistance, central obesity, dyslipidaemia and hypertension, leading to frank disease, including Type 2 DM. | 10342336 |
| Hyperinsulinism, Polycystic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance with compensatory hyperinsulinaemia has been reported in adult polycystic kidney disease (APKD) patients. | 10344369 |
| Communicable Diseases, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | A significant correlation was found between chronic C pneumoniae infection and dyslipidemias in the AMI and CHD groups (P =.003; P =. | 10347340 |
| Increased insulin level, Hypertension, CTCAE, MPV17 gene | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia induce glomerular hypertension and hyperfiltration, which may result in glomerulosclerosis. | 10354294 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Obesity was more prevalent among those with glucose intolerance (IGT + DM) than those with NGT, and those who were obese had the highest prevalence of glucose intolerance. | 10355474 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | A greater percentage of those with glucose intolerance had more than one positive obesity measure as compared to those with NGT, and those with more than one index consistent with obesity had a greater prevalence of IGT + DM. | 10355474 |
| Glucose Intolerance (disease), Demographics Domain, Obesity | Deregulated Nutrient Sensing | Prevalence rates of DM and obesity are high among the Louisiana Coushatta, and obesity is associated with glucose intolerance. | 10355474 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Birth weight, type 2 diabetes, and insulin resistance in Pima Indian children and young adults. | 10372247 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The insulin resistance of low-birth-weight Pima Indians may explain their increased risk for type 2 diabetes. | 10372247 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Many studies have shown that this phenomenoa is associated with a increased morbility of cardiovascular disease, and insulin resistance may be the common link between the risk factors. | 10374288 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The insulin resistance is associated with a clustering of risk factors of cardiovascular disease, more cluste-ring, more resistant. | 10374288 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Although numerous studies have demonstrated obesity as an aspect of the insulin resistance syndrome in cardiovascular disease (CVD), the mechanism is not clear. | 10375053 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Insulin resistance, often associated with obesity, is hypothesized to be involved in the pathogenesis of essential hypertension and may relate to increased left ventricular mass (LVM). | 10385774 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men. | 10388964 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate the association between low birth weight and glucose intolerance in relation to family history of diabetes. | 10388964 |
| Ischemic stroke | Deregulated Nutrient Sensing | Aspects of insulin resistance, as reflected by elevated waist-to-hip ratios and elevated fasting insulin levels, may also contribute to a greater risk of ischemic stroke. | 10388971 |
| Increased insulin level | Deregulated Nutrient Sensing | Whether serum leptin levels are associated with insulin resistance independent of the effects of hyperinsulinemia and adiposity is an important unanswered question. | 10388973 |
| Ischemic stroke, diabetic | Deregulated Nutrient Sensing | Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke. | 10388988 |
| Hypertension, CTCAE, Atherosclerosis | Deregulated Nutrient Sensing | In addition to classic risk factors (e.g., hypertension), insulin resistance is an important risk factor for the development of atherosclerosis. | 10388988 |
| Diabetes Mellitus, Non-Insulin-Dependent, Ischemic stroke | Deregulated Nutrient Sensing | Multiple logistical regression analysis showed that insulin resistance was an independent risk factor for all subtypes of ischemic stroke in type 2 diabetic patients. | 10388988 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Since there is a Pro12Ala substitution in this domain, we tested whether it is related to type 2 diabetes or insulin resistance. | 10389855 |
| Glucose Intolerance (disease), Cholelithiasis | Deregulated Nutrient Sensing | The findings add to evidence that glucose intolerance is associated with a modest increase in the risk of gallstone disease. | 10395054 |
| Dyslipidemias | Deregulated Nutrient Sensing | An increase in serum lipoprotein(a) was also observed in the subjects with the heterozygous mutation, but the Trp64Arg mutation was not associated with other dyslipidemia, blood pressure or ischemic changes on the electrocardiogram. | 10395234 |
| Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. | 10402440 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. | 10402440 |
| Choline Dehydrogenase, Mitochondrial, Cerebrovascular accident | Deregulated Nutrient Sensing | In women, the insulin resistance factor did not predict CHD events (HR 1.06, CI 0.82, 1.36), but factor 2 (previous stroke, low HDL cholesterol and high triglycerides) (HR 1.34, CI 1. | 10402440 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Our study supports the notion that the insulin resistance syndrome is a risk factor for CHD in elderly men. | 10402440 |
| Dyslipidemias, Prediabetes syndrome | Deregulated Nutrient Sensing | Dyslipidemia in patients with diabetic uremic patients remains unclear. | 10412780 |
| Dyslipidemias | Deregulated Nutrient Sensing | Mixed dyslipidemia with moderately elevated low-density lipoprotein (LDL) cholesterol and high levels of triglyceride-rich lipoproteins is common in this condition. | 10412782 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It is not known, however, whether patients with type 2 diabetes on dialysis with this form of dyslipidemia derive benefit from lipid-lowering therapy. | 10412782 |
| Vascular lesions, Dyslipidemias | Deregulated Nutrient Sensing | The resolution of this question is important because the genesis of vascular lesions in this condition is multifactorial and the precise role of dyslipidemia has not been defined. | 10412782 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, a major factor in the pathogenesis of type 2 diabetes mellitus, is due mostly to decreased stimulation of glycogen synthesis in muscle by insulin. | 10413736 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The aim of this study was to investigate the association of insulin secretion and insulin resistance with the development of non-insulin-dependent diabetes mellitus (NIDDM) in obese (body mass index (BMI) > or = 25 kg/m2) and non-obese Japanese. | 10414932 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that most cases of diabetes in Japanese begin with decreased insulin secretion, but a small group of diabetes patients may start with insulin resistance, especially obese subjects. | 10414932 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. | 10414936 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore, OGTT remains a valuable test in diagnosing diabetes and classifying various categories of glucose intolerance. | 10414936 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in Baluchistan province. | 10414940 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | Fasting concentrations and secretion response of insulin, proinsulin, and C-peptide to glucose ingestion was significantly increased in the PI-treated group suggesting a beta-cell dysfunction in addition to peripheral insulin resistance. | 10416516 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Treatment of dyslipidemia and its frequently associated complications (manifest atherosclerosis) is very pretentious from the economic aspect. | 10422514 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To identify abnormally expressed genes contributing to muscle insulin resistance in type 2 diabetes, we screened the mRNA populations from normal and diabetic human skeletal muscle using cDNA differential display and isolated abnormally expressed cDNA clones of mitochondrial-encoded NADH dehydrogenase 1 (ND1), cytochrome oxidase 1, tRNA(leu), and displacement loop. | 10426366 |
| Endocrine System Diseases | Deregulated Nutrient Sensing | Successful treatment for these endocrinopathies resulted in greatly improved blood sugar control because of a reduction in insulin resistance. | 10426577 |
| Cushing Syndrome, Acromegaly | Deregulated Nutrient Sensing | This is the first report describing insulin resistance before and after treatment in a case of acromegaly accompanied by adrenal preclinical Cushing's syndrome. | 10426577 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Among the aged senior citizens in Taiwan, individuals with old age, lower serum high-density lipoprotein level, diabetes and glucose intolerance are at high risk for developing GSD. | 10430304 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Protein tyrosine phosphatases (PTPs) are required for the dephosphorylation of the insulin receptor (IR) and its initial cellular substrates, and it has recently been reported that PTP-1B may play a role in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus (DM). | 10444024 |
| square decimeter, Obesity | Deregulated Nutrient Sensing | These data suggest that the insulin resistance of obesity and DM2 is characterized by the increased expression of a catalytically impaired PTP-1B in adipose tissue and that impaired PTP-1B activity may be pathogenic for insulin resistance in these conditions. | 10444024 |
| Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | We suggest large losses of chromium over many years may exacerbate an already compromised chromium status in NIDDM patients and might contribute to the developing insulin resistance seen in patients with type 2 diabetes. | 10445219 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Associations of C-reactive protein with measures of obesity, insulin resistance, and subclinical atherosclerosis in healthy, middle-aged women. | 10446082 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Obesity, the insulin resistance syndrome, and atherosclerosis are closely linked and may all be determinants of an increased acute-phase response. | 10446082 |
| diabetic | Deregulated Nutrient Sensing | The efficacy and safety of treatment with troglitazone combined with an alpha-glucosidase inhibitor, in obese type 2 diabetic patients who were previously administered alpha-glucosidase inhibitors alone, in improving glycaemic control and reducing insulin resistance were studied. | 10446691 |
| Hypercholesterolemia, Hyperinsulinism, Family history, Atherosclerosis | Deregulated Nutrient Sensing | To study the relationship between hyperinsulinaemia, insulin resistance, leptin and atherosclerosis in subjects with familial hypercholesterolaemia (FH). | 10447228 |
| Family history | Deregulated Nutrient Sensing | Fasting insulin concentrations and calculated insulin resistance were similar in FH subjects with overt CAD compared to those without. | 10447228 |
| Family history | Deregulated Nutrient Sensing | In the absence of other causes of insulin resistance, FH subjects have normal fasting insulin levels and, in general, they are not insulin resistant. | 10447228 |
| Family history, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance appears to play little role in the pathogenesis of accelerated atherosclerosis in FH. | 10447228 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed type II diabetes: the Insulin Resistance Atherosclerosis Study. | 10447516 |
| Hyperglycemia | Deregulated Nutrient Sensing | This could be secondary to hyperglycaemia or insulin resistance or due to a defect in insulin secretion. | 10447516 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (low insulin sensitivity) was not related to the intact proinsulin:insulin ratio in subjects with Type II diabetes. | 10447516 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Insulin resistance was connected with the alterations of substrate utilization in patients with cancer. | 10454248 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | To elucidate the contribution of insulin resistance to substrate utilization, insulin sensitivity and substrate oxidation were examined in 19 cancer patients and five normal controls using the euglycemic hyperinsulinemic glucose clamp technique combined with indirect calorimetry. | 10454248 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | In cancer patients with insulin resistance, decreased glucose uptake was closely associated with a rapid decrease in glucose storage, an increase in fat oxidation and a mild decrease in glucose oxidation, suggesting that insulin resistance was connected with the alterations of substrate utilization which may induce host depletion. | 10454248 |
| Proteinuria, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Data on fasting glucose, obesity, persistent proteinuria, smoking, hypertension, and dyslipidemia were obtained at diagnosis for confirmed incidence cases. | 10455512 |
| Glucose Intolerance (disease), Digestive System Disorders | Deregulated Nutrient Sensing | Such operations may cause digestive disorders, glucose intolerance, and late postsplenectomy infection. | 10457309 |
| Hypoglycemia | Deregulated Nutrient Sensing | However, GH therapy resulted in increased insulin resistance during hypoglycemia, without changes in the counterregulatory hormonal responses, serum IGFBP-1, or serum FFA. | 10459565 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Sixty-seven (84%) had sole hypercholesterolemia, 13 (16%) subjects had mixed dyslipidemia. | 10460070 |
| Obesity | Deregulated Nutrient Sensing | We postulate that this may reflect decreased lipoprotein and/or hepatic lipase activity related to insulin resistance and its association with obesity. | 10460697 |
| Alzheimers Disease", Apolipoprotein E, Data types - Address | Deregulated Nutrient Sensing | Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (APOE)-epsilon4 allele. | 10461029 |
| HAIR-AN syndrome | Deregulated Nutrient Sensing | AN often forms HAIR-AN syndrome consisted of hyperandrogenizm, insulin resistance and AN. | 10462985 |
| Hyperactive behavior, Congenital Abnormality | Deregulated Nutrient Sensing | Of note, syndrome X patients also manifested Na(+)/Li(+) countertransport hyperactivity which, in turn, is known to induce peripheral insulin resistance and consequent abnormalities in insulin secretion and lipid turnover. | 10464063 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | These high-risk CHD survivors would benefit from more aggressive measures aimed at correcting their dyslipidaemias. | 10464785 |
| Left Ventricular Hypertrophy, Hypertensive (finding) | Deregulated Nutrient Sensing | In this study, we examined the relationships between insulin resistance and LVH and LVDF in hypertensive patients from the therapeutic perspective. | 10466471 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | The results of this study indicate that insulin resistance is an important factor affecting LVH and LVDF. | 10466471 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These two groups were entirely comparable for all criteria (sociodemographic criteria, risk factors, cardiovascular history, duration of disease) except for obesity and dyslipidaemia, for which prevalence was higher in the naftidrofuryl group. | 10467531 |
| Myotonic Dystrophy | Deregulated Nutrient Sensing | Myotonic dystrophy (MyD) is a systemic disorder in which insulin resistance is well recognized. | 10468921 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | Reduced glucose effectiveness as a feature of glucose intolerance: evidence in elderly type-2 diabetic subjects. | 10476312 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Attention has been paid to the relationship between insulin resistance and coronary artery disease. | 10478807 |
| Coronary Stenosis, Calcinosis, Atherosclerosis | Deregulated Nutrient Sensing | To evaluate the role of insulin resistance on coronary atherosclerosis, angiographic semiquantitative scores of coronary stenosis and calcification were evaluated. | 10480298 |
| Hypercholesterolemia, Hypertension, CTCAE, Hyperuricemia | Deregulated Nutrient Sensing | The incidence of hypertension, smoking habits, hypercholesterolemia, and hyperuricemia were also the same among the insulin resistance subgroups. | 10480298 |
| diabetic | Deregulated Nutrient Sensing | Compared with control subjects, diabetic patients were more obese, hyperglycemic, and had worse lipid profile, higher blood pressures, UAE, insulin resistance index, plasma insulin, and cortisol concentrations (all P < 0.001) but lower GH concentrations (P < 0.05). | 10480508 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results suggest that abnormalities in vascular reactivity and biochemical markers of endothelial cell activation are present early in individuals at risk of developing type 2 diabetes, even at a stage when normal glucose tolerance exists, and that factors in addition to insulin resistance may be operative. | 10480619 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Women had greater responses than men in both the micro- and macrovascular circulatory tests, but a similar progressive reduction was observed in both sexes with increasing degrees of glucose intolerance. | 10480619 |
| Non-insulin Hypoglycemic, Hyperinsulinism, Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | There is considerable evidence that insulin resistance with compensatory hyperinsulinaemia is an early and modifiable defect in the pathogenesis of non-insulin dependent diabetes (NIDDM). | 10480704 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Using a specific assay, we have addressed the hypothesis that an elevation of serum true insulin concentration, reflecting insulin resistance, is an early event in the pathogenesis of NIDDM. | 10480704 |
| Hyperinsulinism, NEUROD1 wt Allele | Deregulated Nutrient Sensing | These findings are consistent with the hypothesis that the majority of cases of adult onset NIDDM in this population are characterized by the early development of insulin resistance with compensatory true hyperinsulinaemia. | 10480704 |
| Glucose Intolerance (disease), Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | These results suggest a dose-response relation of glucose intolerance at baseline with CHD incidence, CHD mortality, and total mortality, independent of other risk factors, in this cohort of middle-aged and older Japanese-American men. | 10480768 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | There is substantial evidence that glucose intolerance is associated with an increased risk of cardiovascular disease. | 10480780 |
| Gestational Diabetes, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of new criteria for type 2 diabetes on the rate of postpartum glucose intolerance in women with gestational diabetes. | 10486471 |
| Gestational Diabetes, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Our purpose was to determine the impact of the 1997 American Diabetes Association diagnostic criteria for type 2 diabetes mellitus on the rate of postpartum glucose intolerance in women with gestational diabetes. | 10486471 |
| Mice, Inbred NOD, Insulin, diabetic | Deregulated Nutrient Sensing | We have previously shown that alterations of vagal control of heart rate variations are found in more than half of non diabetic obese subjects (Int J Obes 1995) and are associated with a more severe insulin resistance in noninsulin dependent diabetic patients (Metabolism 1998). | 10486673 |
| Mice, Inbred NOD | Deregulated Nutrient Sensing | The aim of this study was to examine whether parasympathetic alterations are also associated with a more severe insulin resistance in non diabetic obese subjects. | 10486673 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | This data suggests that cardiac parasympathetic alterations should take part in the insulin-resistance syndrome and might account for the poor cardiovascular prognosis linked to this syndrome. | 10486673 |
| Increased insulin level, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | However insulin resistance is a common feature of obesity and essential hypertension, it is unclear if chronic hyperinsulinemia per se contributes to sympathetic overactivation. | 10486674 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | The effects of dyslipidemia on left ventricular systolic function in patients with stable angina pectoris. | 10487494 |
| Congestive heart failure, Dyslipidemias, Coronary Artery Disease, Heart failure | Deregulated Nutrient Sensing | Large-scale clinical trials have shown that long-term treatment with lipid-lowering therapy results in a significant reduction in the occurrence of heart failure among patients with coronary artery disease without previous evidence of congestive heart failure, suggesting dyslipidemia may have an adverse effect on left ventricular performance. | 10487494 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Insulin resistance is associated with atherogenic lipoprotein phenotype, including small dense LDL particle, hypertriglycemia and low HDL cholesterol levels. | 10487503 |
| Increased insulin level | Deregulated Nutrient Sensing | In patients with insulin resistance syndrome, troglitazone improved the atherogenic lipoprotein phenotype as well as hyperinsulinemia. | 10487503 |
| atherosclerotic | Deregulated Nutrient Sensing | Our data suggest that troglitazone therapy could reduce the atherosclerotic risk due to insulin resistance even in non-diabetic patients. | 10487503 |
| Syndrome | Deregulated Nutrient Sensing | We report here that antiinsulin receptor (anti-IR) autoantibodies (AIRs) from a newly diagnosed patient with type B syndrome of insulin resistance induced cellular resistance not only to insulin but also to insulin-like growth factor I (IGF-I) for the stimulation of phosphatidylinositol 3-kinase and mitogen-activated protein kinase activities and of glycogen and DNA syntheses. | 10487687 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance, exercise capacity and body composition in subjects with two hypertensive parents. | 10489104 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To study insulin resistance in subjects with strong genetic predisposition to essential hypertension, compared with non-disposed subjects. | 10489104 |
| Obesity | Deregulated Nutrient Sensing | In the present study we have revealed that a specific combination of alleles in OB and OB-R, two candidate genes for obesity, may confer an increased risk for the development of insulin resistance in Nauruan males. | 10490782 |
| Paresis, Traumatic injury | Deregulated Nutrient Sensing | Surgery and accidental trauma are associated with a transient period of insulin resistance, substrate catabolism and muscle weakness. | 10491345 |
| Paresis | Deregulated Nutrient Sensing | In conclusion, the muscle weakness associated with post-operative insulin resistance is not related to a decreased specific tension or a loss of myofibrillar proteins. | 10491345 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine whether the serine/threonine kinase Akt (also known as protein kinase B) is activated in vivo by insulin administration in humans, and whether impaired activation of Akt could play a role in insulin resistance, we measured the activity and phosphorylation of Akt isoforms in skeletal muscle from 3 groups of subjects: lean, obese nondiabetic, and obese type 2 diabetic. | 10491408 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In these 405 patients, HbA1c was > or = 7% in 56.6%, and hypertension and dyslipidaemia were found in 59.8% and 46.5% of the patients, respectively. | 10493712 |
| Obesity, Abdominal, Hyperinsulinism, Dyslipidemias | Deregulated Nutrient Sensing | Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males. | 10497620 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Fasting insulin levels in 30 patients with HCV-related cirrhosis and diabetes mellitus were elevated significantly, which was consistent with insulin resistance. | 10498660 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, insulin resistance and dyslipidaemia in lipodystrophic HIV-infected patients on highly active antiretroviral therapy (HAART). | 10499191 |
| Lipodystrophy, Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, lipodystrophy during HAART was associated with diabetes, insulin resistance and hypertriglyceridaemia. | 10499191 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin-dependent diabetes mellitus patients with insulin resistance. | 10499882 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Although most of patients with non-insulin-dependent diabetes mellitus (NIDDM) have insulin resistance, it is unknown whether a molecule might interfere with insulin action. | 10499882 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, glycoprotein PC-1 activity of dermal fibroblasts is correlated with insulin resistance in patients with NIDDM. | 10499882 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | TNF-alpha, IGF-I and leptin are agents which influence insulin resistance, they play probably a part in the pathogenesis of diabetic nephropathy and influence mutually their production. | 10510538 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance seems to be a metabolic aberration associated with obesity. | 10513036 |
| Obesity | Deregulated Nutrient Sensing | Body fat distribution, especially upper body segment obesity is related to insulin-resistance. | 10513036 |
| Lipolysis, Obesity | Deregulated Nutrient Sensing | Also, the high rate of lipolysis present in obesity and in insulin resistance could lead to an impaired glucose oxidation in muscle. | 10513036 |
| Non-insulin Hypoglycemic, Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Disease | Deregulated Nutrient Sensing | Impaired insulin action is also central to a cluster of diseases including non-insulin dependent diabetes, hypertension, dyslipidemias and atherosclerosis. | 10513036 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Most of them were relatives of diabetics and/or themselves had obesity and/or dyslipidaemia. | 10520305 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, a third of the mothers with type 2 diabetes, and all but 1 of the siblings, had evidence of insulin resistance. | 10520614 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In addition, the incidence of diagnosed and undiagnosed type 2 diabetes or of insulin resistance in the families of adolescents with type 2 diabetes is striking. | 10520614 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | These findings raise the possibility that previously described relationships between soluble adhesion molecules in patients with hypertension, type 2 diabetes, and dyslipidemia may be due to the presence of insulin resistance in these clinical syndromes and suggests that insulin resistance may predispose individuals to coronary heart disease by activation of cellular adhesion molecules. | 10522984 |
| Dyslipidemias, Kidney Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia and the progression of renal disease in chronic renal failure patients. | 10528663 |
| Cancer-related fatigue, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is common in patients with chronic renal failure (CRF), and there is increasing evidence to support the role of dyslipidaemia as a contributing factor in the progression of chronic renal disease. | 10528663 |
| Proteinuria, Cancer-related fatigue, Dyslipidemias, Kidney Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | These results suggest a limited role for dyslipidaemia in the progression of chronic renal disease to dialysis in CRF patients, in contrast with the powerful influence of proteinuria, baseline creatinine clearance and nephropathy type in predicting this progression. | 10528663 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | In univariate analysis we found a higher risk of AMI for men and women with hypertension, dyslipidaemia, diabetes and lower levels of education, for older women, for male smokers and for men with family histories of CHD. | 10534136 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | Low-molecular-weight heparin (LMWH) has been suggested as providing safe, efficient, convenient and possibly more cost-effective anticoagulation for haemodialysis (HD) than unfractionated heparin, with fewer side-effects and possible benefits on uraemic dyslipidaemia. | 10534515 |
| Hypertensive (finding), Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity in hypertensive patients is associated with dyslipidemia and insulin resistance, both of which are improved by weight control. | 10539741 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Overweight, Disease | Deregulated Nutrient Sensing | Overweight is accepted as risk factor for various diseases such as hypertension and diabetes mellitus, dyslipidemias and cardiovascular diseases. | 10540568 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance was found in six (10.4%) patients and diabetes mellitus in five (8.6%) patients in the TB group. | 10546470 |
| Communicable Diseases, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The results suggest that glucose intolerance occurs in the setting of infection and is reversible following adequate antimicrobial treatment. | 10546470 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The purpose of this study was to investigate the association among insulin resistance, high density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD), and to test the hypothesis that HDL-C may ameliorate the adverse effects of insulin. | 10551691 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | A receiver operating characteristic (ROC) curve analysis indicated that HDL-C and insulin resistance were significant discriminators of CHD (area under ROC curve: 0.72 and 0.69, respectively). | 10551691 |
| Increased insulin level, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The interaction between HDL-C and the association of insulin resistance with CHD was significant: subjects with hyperinsulinemia and high HDL-C had no increased risk of CHD. | 10551691 |
| Hypoalphalipoproteinemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Multivariate conditional logistic regression analysis showed that hyperinsulinemic hypoalphalipoproteinemia was a stronger indicator for CHD than either HDL-C or insulin resistance alone (-2 log likelihood: 19.0 vs. 12.6 or 15.7). | 10551691 |
| Increased insulin level, Hypoalphalipoproteinemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Hyperinsulinemic hypoalphalipoproteinemia was a more potent indicator for CHD than either insulin resistance or low serum HDL-C levels alone, and the adverse effects of hyperinsulinemia seem to be ameliorated by high HDL-C levels. | 10551691 |
| Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance and disturbed glucose metabolism cluster within the Insulin Resistance Syndrome (IRS). | 10555133 |
| Primary Hypothyroidism, Hyperprolactinemia, Adrenal cortical hypofunction | Deregulated Nutrient Sensing | The patients also presented DM with insulin resistance, hyperprolactinemia, slight primary hypothyroidism and hypoadrenocorticism. | 10563749 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Association of nonalcoholic fatty liver disease with insulin resistance. | 10569299 |
| Non-alcoholic Fatty Liver Disease, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We tested the hypothesis that there is an association between nonalcoholic fatty liver disease and insulin resistance that is independent of diabetes and obesity. | 10569299 |
| Increased insulin level, Hypoglycemia, Non-alcoholic Fatty Liver Disease, Hypertriglyceridemia | Deregulated Nutrient Sensing | Patients with nonalcoholic fatty liver disease were characterized by fasting and glucose-induced hyperinsulinemia, insulin resistance, postload hypoglycemia, and hypertriglyceridemia. | 10569299 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance [odds ratio (OR) = 15 per percent increase, 95% confidence interval (CI): 3.0 to 70], fasting triglyceride level (OR = 3.1 per mmol/liter increase, 95% CI: 1.1 to 8.9), 180-minute blood glucose level (OR = 4.3 per mmol/ liter decrease, 95% CI: 1.6 to 12), and average insulin concentration in response to oral glucose (OR = 3.0 per 100 pmol/liter increase, 95% CI: 1.5 to 6.2) were independently associated with nonalcoholic fatty liver disease. | 10569299 |
| Increased insulin level, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease is associated with insulin resistance and hyperinsulinemia even in lean subjects with normal glucose tolerance. | 10569299 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease is frequently associated with type 2 diabetes mellitus, obesity, and dyslipidemia, but some patients have normal glucose tolerance or normal weight. | 10569299 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | A close association between insulin resistance and dehydroepiandrosterone sulfate in subjects with essential hypertension. | 10580744 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Steady state plasma glucose was significantly higher in hypertensive subjects indicating insulin resistance compared with control subjects. | 10580744 |
| Obesity | Deregulated Nutrient Sensing | We hypothesized that this variant may be associated with obesity and insulin resistance when combined with a westernized lifestyle. | 10582543 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Leptin is involved in the regulation of bodyweight and metabolism in man and might also be involved in the pathophysiology of the insulin resistance syndrome, which is associated with the development of cardiovascular diseases. | 10583712 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased glucose intolerance related to digoxin treatment in patients with type 2 diabetes mellitus. | 10583713 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | The negative relationship between von Willebrand factor levels and glucose disposal in the low-risk group may indicate that insulin resistance can induce an endothelial dysfunction even in non-diabetic subjects. | 10583718 |
| Weight Gain | Deregulated Nutrient Sensing | This impaired GH secretion together with the clozapine-induced insulin resistance might be mechanisms behind weight gain during clozapine therapy. | 10584769 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | (a) To study whether there was an increased prevalence of glucose intolerance in the parents of probands with Type 1 diabetes and (b) to look for any possible link between the glucose intolerance in the parents with HLA-DQB1 alleles transmitted in excess to the Type 1 diabetes offspring. | 10585618 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is associated with increased risk of atherosclerosis. | 10591678 |
| Increased insulin level, Hyperparathyroidism, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Patients with hyperparathyroidism have alterations in carbohydrate metabolism characterized by insulin resistance, hyperinsulinemia, and glucose intolerance. | 10598202 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Impact of dialysis therapy on insulin resistance in end-stage renal disease: comparison of haemodialysis and continuous ambulatory peritoneal dialysis. | 10607769 |
| Uremia, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance contributes to the pathogenesis of atherosclerotic cardiovascular disease and, thus, has an important impact on the mortality of uraemic patients. | 10607769 |
| Uremia | Deregulated Nutrient Sensing | Haemodialysis (HD) is known to improve insulin resistance observed in uraemia. | 10607769 |
| Uremia | Deregulated Nutrient Sensing | However, it is not known whether continuous ambulatory peritoneal dialysis (CAPD) alleviates insulin resistance in adult uraemic patients. | 10607769 |
| Uremia, HD Term Type | Deregulated Nutrient Sensing | The objective of this study was to compare the effect of two different dialysis modalities, HD and CAPD, on insulin resistance in adult uraemic patients and to identify the possible predictive factors for changes in insulin resistance. | 10607769 |
| Kidney Failure, Chronic, HD Term Type | Deregulated Nutrient Sensing | Insulin resistance was examined in 19 non-diabetic patients with end-stage renal disease (ESRD) before and after dialysis therapy (HD, n=10; CAPD, n=9), as well as in 10 healthy controls using the hyperinsulinaemic euglycaemic glucose clamp technique. | 10607769 |
| HD Term Type, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | CAPD therapy, in spite of its possible adverse effects in patients with atherosclerotic disease, has been shown to improve insulin resistance in adult uraemic patients, similarly to HD therapy. | 10607769 |
| Glucose Intolerance (disease), Acromegaly, Diabetes Mellitus | Deregulated Nutrient Sensing | Although growth hormone excess (acromegaly) in association with glucose intolerance and diabetes mellitus is well documented in adult medicine, it is much less common in the paediatric age group. | 10614552 |
| Obesity | Deregulated Nutrient Sensing | Our data suggest that among Eskimo people insulin resistance may be less prevalent or severe than among American Indians, but that obesity is associated with increased insulin resistance. | 10615832 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia may be an important contributor to this. | 10617243 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Persons in the NIDDM and IGT groups had decreased beta cell function compared to persons in the NGT group, but did not have increased peripheral insulin resistance as estimated from the OGTT data. | 10619320 |
| Increased insulin level, Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | Our data demonstrated that in this cohort of elderly hypertensive participants with a high prevalence of central obesity, impaired glycemic control was common, but was not associated with fasting hyperinsulinemia or peripheral insulin resistance. | 10619320 |
| Glucose Intolerance (disease), Cardiovascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Increased risk for cardiovascular disease in persons with glucose intolerance (impaired glucose tolerance and type 2 diabetes mellitus) is not fully explained by concomitant elevations in traditional atherosclerosis risk factors. | 10634338 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Hyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function. | 10634338 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Hyperinsulinemia is associated primarily with impaired fibrinolysis in subjects with glucose intolerance. | 10634338 |
| Increased insulin level, Glucose Intolerance (disease), Thrombosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Excess risk for cardiovascular disease associated with hyperinsulinemia and glucose intolerance may be mediated in part by enhanced potential for acute thrombosis. | 10634338 |
| Weight Gain | Deregulated Nutrient Sensing | Prospective cohort study of the relationship of markers of insulin resistance and secretion with weight gain and changes in regional adiposity. | 10643681 |
| Obesity | Deregulated Nutrient Sensing | Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man. | 10643689 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Pakistan National Diabetes Survey prevalence of glucose intolerance and associated factors in North West at Frontier Province (NWFP) of Pakistan. | 10646320 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In contrast, there was no association between insulin resistance and either autonomic function or the circadian rhythm of sympathovagal balance, regardless of diabetes status. | 10648499 |
| Biliary calculi, Diabetes Mellitus | Deregulated Nutrient Sensing | We hypothesized that insulin resistance rather than diabetes status may be a primary factor involved in gallstone formation. | 10655249 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Borderline hypertensive patients display normal glucose tolerance with basal insulin resistance and normal dynamic insulin sensitivity. | 10656171 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Because borderline hypertension often degenerates into overt disease, our results point to a progression that leads to the well-known insulin resistance proper to sustained hypertension. | 10656171 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Cross-sectional studies have demonstrated an association between high non-esterified fatty acid (NEFA) concentrations and glucose intolerance. | 10656229 |
| Hyperglycemia, Attack behavior, Dyslipidemias | Deregulated Nutrient Sensing | Association of dyslipidemia with hyperglycemia, the high level of lipidic peroxides and the diminution of body capacity of annihilating them, actually represents an increase in risk factors for onset of vascular attacks. | 10660970 |
| Obesity, Abdominal, Obesity | Deregulated Nutrient Sensing | Birth weight and the insulin resistance syndrome: association of low birth weight with truncal obesity and raised plasminogen activator inhibitor-1 but not with abdominal obesity or plasma lipid disturbances. | 10663216 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The insulin resistance syndrome was defined as the combination of hypertension, insulin resistance and dyslipidaemia. | 10663216 |
| Obesity, Abdominal, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Low birth weight predicts high blood pressure, insulin resistance, truncal obesity and high plasminogen activator inhibitor-1 activity but not the abdominal obesity or dyslipidaemia present in the insulin resistance syndrome. | 10663216 |
| Dysgeusia | Deregulated Nutrient Sensing | The cluster of disturbances associated with low birth weight is a subset of the disturbances that are clustered in the general population as the insulin resistance syndrome. | 10663216 |
| Presenile dementia, Dyslipidemias | Deregulated Nutrient Sensing | The effect of APOE on dementia may be mediated through dyslipidemia and atherogenesis through its effect on cholesterol metabolism. | 10668701 |
| Presenile dementia, Dyslipidemias, Data types - Address | Deregulated Nutrient Sensing | Presence of APOE epsilon4/* seems to increase the risk for dementia and AD independently of its effect on dyslipidemia and atherogenesis. | 10668701 |
| Dyslipidemias | Deregulated Nutrient Sensing | The "classic" risk factors--like dyslipidemia--are not always present in significant percentages in patients suffering from PAOD of the lower limbs. | 10670255 |
| Atherosclerosis, NEUROD1 wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to clarify whether insulin resistance contributes to atherosclerosis in patients with non-insulin-dependent diabetes mellitus (NIDDM). | 10670747 |
| Cutaneous plaque, Atherosclerosis | Deregulated Nutrient Sensing | These data suggest that insulin resistance in the peripheral tissues but not the splanchnic tissues may independently contribute to carotid arterial wall thickness and especially to plaque lesion, and that habitual exercise might reduce insulin resistance leading to attenuation of atherosclerosis. | 10670747 |
| Premenopause, Antihypertensive Agents | Deregulated Nutrient Sensing | The hypothesis to be tested in hypertensives was that men have more pronounced insulin resistance and other cardiovascular risk factors than pre-menopausal, but not post-menopausal, women. | 10673732 |
| Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Malignant Neoplasms, Obesity, Hypertension, CTCAE, Disease | Deregulated Nutrient Sensing | Obesity greatly increases the risks of developing diseases, including diabetes mellitus, hypertension, dyslipidaemia, coronary artery disease, and some cancers. | 10673848 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | This clustering is attributed to an insulin resistance syndrome promoted by abdominal obesity. | 10678282 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Relative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension. | 10678546 |
| Hypertensive disease, Hyperinsulinism, Muscle hypertrophy | Deregulated Nutrient Sensing | High systolic blood pressure was related to vascular hypertrophy, whereas hyperinsulinaemia and insulin resistance were not, suggesting that longstanding high blood pressure is a far more important determinant for structural vascular changes than insulin resistance at this stage of the hypertensive disease. | 10678546 |
| Hypertensive (finding), Hyperinsulinism | Deregulated Nutrient Sensing | However, hyperinsulinaemia and insulin resistance were associated with low distensibility of the common carotid arteries in the subgroup of never treated hypertensive patients. | 10678546 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest that higher plasma IRI levels and/or insulin resistance are closely related to the pathogenesis of hypertension in patients with diabetes mellitus. | 10678547 |
| Uremia, Dyslipidemias | Deregulated Nutrient Sensing | Understanding the mechanism(s) of elevated apoC-III in uremia may help to clarify the causes of uremic dyslipidemia. | 10681649 |
| Gestational Diabetes, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Women diagnosed with GDM who have unrecognized Type 2 DM are also at high risk, but perinatal mortality is low in women with milder degrees of glucose intolerance in pregnancy. | 10691157 |
| Cushing Syndrome, Hypertension, CTCAE | Deregulated Nutrient Sensing | Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome. | 10692082 |
| Obesity | Deregulated Nutrient Sensing | Increasing obesity and plasma cortisol concentrations make independent and sex-specific contributions to variations in blood pressure and aspects of the insulin resistance syndrome. | 10692082 |
| Hyperhomocysteinemia, Coronary Artery Disease | Deregulated Nutrient Sensing | Hyperhomocysteinemia as well as insulin resistance are considered to be risk factors for the development of coronary artery disease. | 10692093 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | However, a 2-h clamp results in lower insulin sensitivity values in elderly, hypertensive patients due to the fact that steady state is not reached, demonstrating a higher prevalence of insulin resistance in such a population. | 10697300 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We examined the effect of an oleic-acid-rich diet on insulin resistance and endothelium-dependent vasoreactivity in type 2 diabetes. | 10700478 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Change from polyunsaturated to monounsaturated diet in type 2 diabetes reduced insulin resistance and restored endothelium-dependent vasodilatation, suggesting an explanation for the anti-atherogenic benefits of a Mediterranean-type diet. | 10700478 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance, a well-known feature of obesity, is associated with several pathological changes, which are potentially arrhythmogenic. | 10701717 |
| Premature ventricular contractions, ventricular mass | Deregulated Nutrient Sensing | It appears that in obese normotensive subjects, ventricular ectopic beats are related to age, insulin resistance, left ventricular mass index, and decreased intracellular magnesium content. | 10701717 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Serum N-acetyl-beta-D-gulucosaminidase activity increases in association with insulin resistance in patients with coronary artery disease. | 10704622 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Our results suggested that serum NAG activity correlates with the severity of coronary artery disease in relation to plasma insulin level and insulin resistance, and thus can be an indicator of coronary artery disease based upon abnormalities of glucose metabolism. | 10704622 |
| Hyperlipidemia, Cardiovascular Diseases, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | It is well known that obesity is closely related to non-insulin-dependent diabetes mellitus, hyperlipidemia, hypertension and cardiovascular disease, and the insulin resistance associated with obesity is supposed to play a central role for the development of these diseases. | 10704695 |
| Obesity, Hostility | Deregulated Nutrient Sensing | The results are consistent with those of prior research and also suggest that, in older men, hostility may be associated with a pattern of obesity, central adiposity, and insulin resistance, which can exert effects on blood pressure and serum lipids. | 10705906 |
| Coronary heart disease, diabetic | Deregulated Nutrient Sensing | LDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: The Strong Heart Study. | 10712410 |
| Dyslipidemias, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, even at concentrations well below the National Cholesterol Education Program target of 130 mg/dL, LDL cholesterol is a strong independent predictor of coronary heart disease in individuals with diabetes, even when components of diabetic dyslipidemia are present. | 10712410 |
| diabetic | Deregulated Nutrient Sensing | Increased urinary albumin excretion (UAE) in diabetic and nondiabetic subjects is frequently associated with insulin resistance syndrome and central obesity. | 10718833 |
| Cushing Syndrome | Deregulated Nutrient Sensing | Cushing's syndrome is also characterized by central obesity and insulin resistance. | 10718833 |
| daytime sleepiness, Sleep Apnea, CTCAE, Obesity, Visceral, Fatigue | Deregulated Nutrient Sensing | Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. | 10720054 |
| Apnea, Obesity | Deregulated Nutrient Sensing | 3) Is apnea a factor independent from obesity in the development of insulin resistance? | 10720054 |
| Obesity, Visceral, Sleep Apnea, CTCAE, Sequela of disorder | Deregulated Nutrient Sensing | We conclude that there is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition. | 10720054 |
| Primary malignant neoplasm, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Over the 4 h feeding period, changes in insulin and glucose concentrations in cancer patients suggested relative glucose intolerance. | 10731472 |
| Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with the clinical syndrome of insulin resistance--defined as diabetes, hypertension, and obesity--mortality was reduced by abciximab treatment from 5.1% to 2.3%, p = 0.044. | 10732889 |
| Dyslipidemias, Premature coronary artery atherosclerosis | Deregulated Nutrient Sensing | Hereditary dyslipidemias and combined risk factors in children with a family history of premature coronary artery disease. | 10735834 |
| Premature coronary artery atherosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Schoolchildren aged 10-11 with a family history of premature coronary artery disease (CAD), were examined in order to identify children with genetically determined dyslipidemias and a combination of risk factors. | 10735834 |
| Hyperlipidemia, Hypercholesterolemia, Dyslipidemias, Family history, Hereditary | Deregulated Nutrient Sensing | Of the remaining 38 children, 23 had non-hereditary abnormalities of low (LDL) or high density lipoprotein (HDL) cholesterol or apolipoprotein B. Fifteen children were suspected to have genetically determined dyslipidemias or a combination of risk factors: in four, possible familial hypercholesterolaemia (FH); in five, possible familial combined hyperlipidaemia; in three, hereditary low HDL cholesterol; and in three a combination of high LDL cholesterol and Lp(a) lipoprotein concentrations. | 10735834 |
| Glucose Intolerance (disease), Acromegaly, Has difficulty doing (qualifier value) | Deregulated Nutrient Sensing | Our data confirm that in acromegalic patients: airway difficulties occurred more frequently; severe haemodynamic instability did not typically occur during surgery for acromegaly; pulmonary gas exchange was not altered during operation; glucose intolerance may be an intraoperative problem; and fluid regulation may be altered. | 10743450 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Main risk factors (cholesterol, smoking, systolic blood pressure, glucose intolerance and diabetes) could only explain one third of this gradient. | 10746111 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance, 2 h plasma glucose, insulin and obesity aggregated as the major domain. | 10746487 |
| Glucose Intolerance (disease), Cirrhotic, shunt occlusion | Deregulated Nutrient Sensing | These results indicate that decreased portal flow due to extrahepatic shunt and consequent impairment of insulin metabolism play a role in glucose intolerance observed in cirrhotic patients and that shunt occlusion improves glucose metabolism. | 10749336 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | A study was undertaken in order to determine if hypertension in Bahrainis is associated with the same factors as those related to glucose intolerance. | 10750606 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | The age-adjusted prevalence of hypertension (defined as current treatment for hypertension, systolic blood pressure > or = 160 mmHg or diastolic blood pressure > or = 95 mmHg) rose with increasing degrees of glucose intolerance. | 10750606 |
| Increased insulin level | Deregulated Nutrient Sensing | These results show that small size at birth is associated with increased insulin resistance and hyperinsulinemia in young adult life but that these relationships are restricted to the male gender in this age group. | 10751205 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pravastatin compared to bezafibrate in the treatment of dyslipidemia in insulin-treated patients with type 2 diabetes mellitus. | 10751747 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Both HMG-CoA reductase inhibitors and fibric acid derivates are used for the treatment of dyslipidemia in Type 2 diabetes patients. | 10751747 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | The independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear. | 10753036 |
| Anemia | Deregulated Nutrient Sensing | Our study proves the beneficial effect of EPO treatment on insulin resistance in dialysis patients which could be attributed to the EPO itself and not to the correction of anaemia and is accompanied by improvement in triglyceride levels. | 10754408 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | The most frequent vascular risk factors were hypertension (42%), smoking (64%), and dyslipidemia (52%); 30% had previous ischemic heart disease. | 10763352 |
| First Degree Relative, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. | 10769277 |
| Increased insulin level, Atherosclerosis | Deregulated Nutrient Sensing | Among the pathogenetic factors leading to atherosclerosis, the role of insulin resistance and hyperinsulinemia as independent risk factors is still under debate. | 10769277 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this study, we examined the association between ED and insulin resistance in normotensive and normoglycemic first-degree relatives (FDRs) of patients with type 2 diabetes mellitus (DM). | 10769277 |
| Demographics Domain | Deregulated Nutrient Sensing | There is a significant association between ED and insulin resistance in young FDRs of DM subjects independent of the classic cardiovascular risk factors. | 10769277 |
| Fetal Growth Retardation | Deregulated Nutrient Sensing | Insulin resistance early in adulthood in subjects born with intrauterine growth retardation. | 10770173 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Mild-to-severe hypertension was found in 24 of 50 (48%) patients, type-2 diabetes in 12 of 50 (24%), and glucose intolerance in 6 of 50 (12%) patients. | 10770179 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin-like growth factor I (IGF-I) is an important regulator of many aspects of growth, differentiation, and development, and as low birth weight has been associated with impaired glucose tolerance and overt type 2 diabetes in adult life, we considered the genes encoding the IGF-I and the IGF-I receptor (IGF-IR) as candidates for low birth weight, insulin resistance, and type 2 diabetes. | 10770205 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance was demonstrated in hypertensive patients and in salt-sensitive subjects. | 10775552 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These results suggest that insulin resistance, salt sensitivity, and failed nocturnal fall in blood pressure are associated with each other in subjects with essential hypertension. | 10775552 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Since this amino acid substitution may cause a reduction in the transcriptional activity of PPARgamma, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. | 10777704 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | From this model springs the inference that NIDDM is a cumulative dyslipidaemia-over-time process. | 10777986 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Despite assuming that obesity and insulin resistance precedes DM, FFQ may not be useful in the assessment of unfavorable dietary patterns among subjects at risk for glucose intolerance, such as Japanese-Brazilians with elevated BMI. | 10778035 |
| Tumor necrosis, Non-insulin Hypoglycemic, Diabetes Mellitus | Deregulated Nutrient Sensing | GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity. | 10778531 |
| Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Hence, it is likely that there is a close interaction between GLUT-4, TNF-alpha, EFAs, daf-genes, melatonin and leptin that may have relevance to the development of insulin resistance, obesity, NIDDM, complications due to NIDDM, longevity and ageing. | 10778531 |
| diabetic | Deregulated Nutrient Sensing | Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients. | 10781642 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Therefore, although the individual risk of hypertriglyceridemia is increased in women with the haplotype T, C at -482, -455, it appears that the -482, -455 and SstI APOC-III gene polymorphisms are not major contributors to the risk of dyslipidemia in the population of northern France. | 10781646 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Type 2 diabetic patients exhibited the classical dyslipidemia of the insulin resistance syndrome and delayed clearance of both hepatic and intestinal particles. | 10781648 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | The association between angiotensin-converting enzyme (ACE) as well as apolipoprotein B polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial. | 10781757 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Atorvastatin for the management of Type 2 diabetic patients with dyslipidaemia. | 10782562 |
| TG gene, Cardiac complication, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia, particularly increased triglycerides (TG) and low HDL-cholesterol (HDL-C), represents an important risk factor for Type 2 diabetes (T2DM) macrovascular complications. | 10782562 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The sensitivity for detecting dyslipidemia was generally higher for abdominal obesity, based on either WHR or WC, than for criteria based on the other risk factors under study. | 10785570 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Body mass index, insulin resistance, mutations in other candidate genes (Asn291Ser and Asp9Asn in the LPL gene, apoE isoforms, polymorphisms in the apoA-II gene and in the apoAI-CIII-AIV gene cluster, and in the IRS-1 gene) could be ruled out as possible factors contributing to the expression of hypertriglyceridemia in this family. | 10787434 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | This relationship was largely explained by obesity, hypertension, and dyslipidemia. | 10789610 |
| Acromegaly | Deregulated Nutrient Sensing | Although insulin resistance is a common feature of acromegaly, it remains unclear whether the extent of insulin resistance per se determines the abnormal glucose tolerance. | 10792333 |
| Hyperglycemia | Deregulated Nutrient Sensing | Several other questions remain open due to scanty informations on LDL-concentrations, and a complete lack of data concerning insulin/insulin resistance, hyperglycemia, respectively. | 10802893 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Association between angiotensin-converting enzyme (ACE) as well as apolipoprotein (apo) AI, B, and E polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial. | 10803441 |
| Metabolic Diseases, Obesity | Deregulated Nutrient Sensing | Accordingly, it is suggested that evaluating Pmax by ultrasonography may be the most sensitive and reliable method of predicting insulin resistance-associated metabolic derangements in children, compared with other conventional indices of obesity. | 10804731 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | These results suggest that there is an association between high insulin resistance and coronary vascular endothelial cell dysfunction, and that insulin resistance may be an indicator of early stage coronary artery atherosclerosis not detectable by angiography. | 10806013 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In Wadena, glucose intolerance increased sharply among the obese. | 10808062 |
| Insulin resistance - type A | Deregulated Nutrient Sensing | The type B insulin-resistance syndrome is characterized by the presence of anti-insulin receptor antibodies that cause severe insulin resistance. | 10808065 |
| Hypersensitivity | Deregulated Nutrient Sensing | We describe a patient with type B insulin resistance syndrome who was treated successfully with human recombinant (hr) IGF-1, although this treatment provoked a severe allergic reaction. | 10808065 |
| Insulin resistance - type A | Deregulated Nutrient Sensing | The patient was diagnosed with type B insulin-resistance syndrome by the presence of anti-insulin receptor antibodies. | 10808065 |
| Increased insulin level, Hypertriglyceridemia, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Central body fat distribution has been shown to be related to hyperinsulinemia, insulin resistance, hypertriglyceridemia, and atherosclerosis to a greater degree than general obesity. | 10808240 |
| Dyslipidemias | Deregulated Nutrient Sensing | Bezafibrate and simvastatin combination therapy for diabetic dyslipidaemia: efficacy and safety. | 10809995 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Reverse correlation between urine nitric oxide metabolites and insulin resistance in patients with type 2 diabetes mellitus. | 10811296 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We studied the possible relationship between nitric oxide (NO) production and insulin resistance in patients with type 2 diabetes mellitus. | 10811296 |
| diabetic | Deregulated Nutrient Sensing | Glucose infusion rate (GIR) was measured as a reverse index for insulin resistance by euglycemic glucose clamp study using an artificial pancreas in 20 of 102 diabetic patients. | 10811296 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings suggest that NO production is closely related with insulin resistance in patients with type 2 diabetes. | 10811296 |
| Hypertriglyceridemia, Hypoalphalipoproteinemia, Familial | Deregulated Nutrient Sensing | Hypertriglyceridemia and low high density lipoprotein-cholesterol (HDLc) seem to be related with insulin resistance. | 10812581 |
| Alzheimers Disease", Apolipoprotein E, Data types - Address | Deregulated Nutrient Sensing | Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele. | 10818510 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Correlative factors of insulin resistance in essential hypertension. | 10821137 |
| Hypertension, CTCAE, metabolic disturbance | Deregulated Nutrient Sensing | Essential Hypertension (EH) is correlated with a metabolic disturbance characterized by insulin resistance (IR). | 10821137 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. | 10821297 |
| Carotid Intima-Media Thickness, Cardiovascular Diseases | Deregulated Nutrient Sensing | To assess whether there is an association between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects free from symptomatic cardiovascular disease. | 10821297 |
| Hypertension, CTCAE, Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | It is concluded that the association between insulin resistance, as assessed by the HOMA method in non-diabetic subjects, and atherosclerosis is explained by its covariance with established risk factors for cardiovascular disease of which hypertension seems to be the most significant. | 10821297 |
| Hypertensive (finding), Hypertension, CTCAE, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | To compare the muscle morphology in hypertensive subjects with that in controls and to test the hypothesis of a relation between heart rate, development of hypertension and muscle morphology that is independent of glucose intolerance. | 10826558 |
| Retinal Diseases, Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest that an abnormal fibrinolytic state, especially overproduction of PAI-1, may be a pathogenic factor in the development of diabetic complications such as retinopathy, which may be improved by correction of the insulin resistance with troglitazone. | 10831180 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity is a major risk factor for cardiovascular disease frequently associated with hypertension, dyslipidemia, and diabetes. | 10831182 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Report of the Working Group on Hypercholesterolemia and Other Dyslipidemias. | 10834048 |
| physiopathological | Deregulated Nutrient Sensing | Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance. | 10834425 |
| Apolipoprotein E | Deregulated Nutrient Sensing | Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study. | 10834428 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance and the apolipoprotein (apo) allele e4 have both been associated with coronary heart disease (CHD). | 10834428 |
| Autoimmune reaction | Deregulated Nutrient Sensing | Moreover, it can also suggest that both autoimmune insulitis and insulin resistance may coexist in parallel. | 10838742 |
| Chronicity, Dyslipidemias | Deregulated Nutrient Sensing | The reduction of the E-selectin plasma levels was proportional to the values of total cholesterol and triglycerides; the chronicity and the dyslipidemia may be responsible for the basal diminished biosynthetic endothelial function; in the severe hypercholesterolemics the lipid-lowering treatment caused a significant decrease of E-selectin, due to a probable reduced endothelial irritation dependent on the hyperlipemic stress. | 10838833 |
| Ventricular hypertrophy | Deregulated Nutrient Sensing | Left ventricular concentric remodeling rather than left ventricular hypertrophy is related to the insulin resistance syndrome in elderly men. | 10840010 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | Associations between left ventricular (LV) geometry and the insulin resistance syndrome have been found, mostly in small studies of middle-aged hypertensives. | 10840010 |
| Hypertrophy | Deregulated Nutrient Sensing | Several components of the insulin resistance syndrome were related to thick LV walls and concentric remodeling but less to LV hypertrophy in this population-based sample of elderly men. | 10840010 |
| Demographics Domain | Deregulated Nutrient Sensing | We conclude that this gene abnormality does not play a role in the pathogenesis of insulin resistance and type-2 DM. | 10844412 |
| Non-insulin Hypoglycemic, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A study of dyslipidemia and platelet adhesiveness in non-insulin dependent diabetes mellitus. | 10846630 |
| Dyslipidemias, Obesity, Arteriopathic disease | Deregulated Nutrient Sensing | Obesity, dyslipidemia and increased platelet adhesiveness are interconnected and make diabetics more susceptible to arterial disease with increased risk of vascular episodes. | 10846630 |
| Pancreas | Deregulated Nutrient Sensing | Reduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels. | 10852463 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus is associated with insulin resistance, reduced B cell function, and an increase in the proinsulin (PI) to immunoreactive insulin (IRI) ratio (PI/IRI); the latter is thought to be an indication of B cell dysfunction. | 10852463 |
| Increased insulin level, Endometrial Carcinoma | Deregulated Nutrient Sensing | [The nature of hyperinsulinemia (insulin resistance) in endometrial carcinoma: of plasma levels of insulin and c-peptide]. | 10853419 |
| Increased insulin level, Endometrial Carcinoma | Deregulated Nutrient Sensing | Obese (BMI index 28 kg/m2) reproductive endometrial carcinoma patients showed pronounced hyperinsulinemia and resistance to insulin. | 10853419 |
| Iron deficiency anemia | Deregulated Nutrient Sensing | [Unusual cause of chronic iron-deficiency anemia and insulin resistance: cholesterol embolism]. | 10855367 |
| Anemia | Deregulated Nutrient Sensing | A 73 year-old female patient developed CED disclosed by iron deficiency anemia with chronic digestive bleeding associated with major insulin resistance. | 10855367 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance has not been reported although prior diabetes is often mentioned as a predisposing factor for atherosclerosis. | 10855367 |
| Arterial Stiffness, diabetic | Deregulated Nutrient Sensing | The insulin resistance syndrome is related to arterial stiffness in diabetic subjects. | 10855542 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Whether the insulin resistance syndrome is also related to arterial stiffness in non-diabetic subjects is less clear. | 10855542 |
| Hypertension, CTCAE, Endothelial dysfunction | Deregulated Nutrient Sensing | A possible link between endothelial dysfunction and insulin resistance in hypertension. | 10855737 |
| Atherosclerosis of renal artery, Coronary Artery Disease, diabetic, Atherosclerosis | Deregulated Nutrient Sensing | Carotid artery atherosclerosis in type-2 diabetic and nondiabetic subjects with and without symptomatic coronary artery disease (The Insulin Resistance Atherosclerosis Study). | 10856382 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Patients with dyslipidemia are at increased risk of coronary heart disease (CHD), while treatment to reduce low density lipoprotein cholesterol (LDL-C) concentrations lessens this risk. | 10856770 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our prospective findings are consistent with previous, mainly cross-sectional reports, suggesting that low levels of testosterone and SHBG play some role in the development of insulin resistance and subsequent type 2 diabetes. | 10857940 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Rosiglitazone is a potent peroxisome proliferator-activated receptor gamma agonist that decreases hyperglycemia by reducing insulin resistance in patients with type 2 diabetes mellitus. | 10859151 |
| Vascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | If present, this association may be modified by diabetes, which is also associated with dyslipidemia that predisposes to macrovascular disease. | 10861896 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The dyslipidemia in present study not correlate with the risk of developing cardiovascular disease reinforcing the earlier finding of increased levels of HDL-c at higher altitudes. | 10862268 |
| Obesity | Deregulated Nutrient Sensing | These results suggest that the degree of clustering of risk variables of Syndrome X varies with age from childhood to adulthood and is likely influenced by the age-related changes in obesity and the attendant insulin resistance. | 10866058 |
| Kidney Failure, Chronic, Arteriosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Elevated plasma homocysteine (Hcy), dyslipidemia and hemorheological abnormalities all occur commonly in end-stage renal disease (ESRD) and are recognized risk factors for arteriosclerosis. | 10867536 |
| Increased insulin level | Deregulated Nutrient Sensing | The goal of this study was to define the relationship between a quantitative measure of the ability of physiological hyperinsulinemia to stimulate glucose disposal and several surrogate measures of insulin resistance. | 10868826 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | Time trends in testing for glycemic test and control and screening for dyslipidemia, use of lipid-lowering drugs, and microalbuminuria were evaluated as measures of care process. | 10868830 |
| Obesity, diabetic | Deregulated Nutrient Sensing | Reduced beta-cell compensation to the insulin resistance associated with obesity in members of caucasian familial type 2 diabetic kindreds. | 10868835 |
| Increased insulin level, Glucose Intolerance (disease), Hyperglycemia | Deregulated Nutrient Sensing | Transgenic mice exhibit fasting hyperglycemia and hyperinsulinemia and glucose intolerance in later life, indicating an age-related decline in glucocompetence. | 10868969 |
| Increased insulin level | Deregulated Nutrient Sensing | Sex hormone-binding globulin as a marker for hyperinsulinemia and/or insulin resistance in obese children. | 10870035 |
| Coronary heart disease | Deregulated Nutrient Sensing | High triglyceride associated with reduced HDL, indicating insulin resistance and small dense LDL, was shown to be associated with excess coronary disease. | 10872616 |
| Weight Gain | Deregulated Nutrient Sensing | All the risk factors tended to cluster, and this was shown to be promoted by insulin resistance induced by weight gain. | 10872616 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The Framingham Study is now engaged in quantifying the independent contributions of homocysteine Lp(a), insulin resistance, small dense LDL, C reactive protein, clotting factors and genetic determinants of cardiovascular disease. | 10872616 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). | 10880413 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Of CD1 mice fed with betel-nut or associated nitrosamines 8.5% develop glucose intolerance with marked obesity. | 10884715 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Role of insulin resistance in heart and skeletal muscle F-18 fluorodeoxyglucose uptake in patients with non-insulin-dependent diabetes mellitus. | 10888395 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Although elevations in plasma free fatty acid (FFA) concentrations have been implicated in reduced myocardial 18fluorine-fluoro-2-deoxy-D-glucose uptake (MFU), the specific role of whole-body insulin resistance in MFU in patients with NIDDM compared with skeletal muscle metabolism remains controversial. | 10888395 |
| Skeletal muscle structure, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Insulin resistance is the most essential factor for both heart and skeletal muscle FDG uptake in patients with NIDDM. | 10888395 |
| Glucose Intolerance (disease), Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The family history of diabetes (RR 10.1; IC95% 2.7-15.8, p < 0.01), glucose intolerance (RR 9.8; IC95% 1.7-13.4, p < 0.01), abdominal obesity (RR 6.1; IC95% 1.5-10.1, p < 0.01), and the low FG/I ratio and high IL 2-h PG (RR 3.3; IC95% 1.4-8.2, p < 0.05) were strong predictors for type 2 diabetes. | 10893848 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia. | 10894818 |
| Obesity | Deregulated Nutrient Sensing | Further, black offspring of both diabetics and non-diabetics had unfavorable profiles of obesity and abdominal fat measures, blood pressure, insulin, and insulin resistance index (P = 0.0001). | 10896837 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin (P = 0.0001) and the insulin resistance index (P = 0.0001) were independently associated with conditions of impaired fasting glucose or type 2 diabetes. | 10896837 |
| Williams Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Our results indicate that insufficient insulin secretion, which could not overcome insulin resistance, might play a crucial role in the pathophysiology and progression of diabetes in WS along with insulin resistance due to a post-receptor defect. | 10898130 |
| Hyperuricemia | Deregulated Nutrient Sensing | Physical activity was associated with serum insulin level and with factors associated with insulin, ie, heart rate, hyperuricemia, diastolic blood pressure, and high-density lipoprotein cholesterol level, and with gamma-glutamyltransferase level, a possible marker of hepatic insulin resistance. | 10904453 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance and diabetes mellitus are associated with physical inactivity, but it is unclear whether preventive interventions should aim at increasing overall energy expenditure or increasing participation in vigorous, fitness-enhancing activities. | 10909950 |
| Increased insulin level | Deregulated Nutrient Sensing | Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance. | 10911003 |
| Tumor necrosis | Deregulated Nutrient Sensing | Previous studies have demonstrated a role for tumor necrosis factor-alpha (TNF-alpha) in insulin resistance. | 10916281 |
| Atherosclerosis | Deregulated Nutrient Sensing | Since the IMT-CCA is an earlier asymptomatic sign of atherosclerosis, this study indicates that insulin resistance per se may accelerate atherogenesis. | 10918528 |
| diabetic | Deregulated Nutrient Sensing | [Alteration of fatty acid components of erythrocyte membrane and insulin resistance in diabetic patients]. | 10923482 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | To study the effect of alteration of erythrocyte membrane fatty acid components and fluidity on insulin resistance (ISR) in NIDDM patients. | 10923482 |
| Hyperlipidemia, USF1 wt Allele | Deregulated Nutrient Sensing | Dyslipidemias and insulin resistance often present simultaneously, as in familial combined hyperlipidemia (FCHL), and therefore may have a common genetic background. | 10924736 |
| Hyperlipidemia, USF1 wt Allele | Deregulated Nutrient Sensing | We conclude that the Ala12 isoform of PPARgamma2 ameliorates the insulin resistance and unfavorable lipid and lipoprotein profiles in FCHL and hyperlipidemic elderly subjects. | 10924736 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia. | 10924736 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | Therefore, 228 nondiabetic members of FCHL families and 866 nondiabetic elderly subjects with (n=217) and without dyslipidemia (n=649) were genotyped. | 10924736 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | The allele frequencies of the Pro12A1a substitution did not differ between elderly subjects with or without dyslipidemia or 27 probands with FCHL. | 10924736 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | However, this substitution was associated with low fasting insulin levels both in FCHL family members (P = 0.036 adjusted for gender and age) and elderly subjects with dyslipidemia (P=0.050) but not in elderly subjects without dyslipidemia (P=0.080). | 10924736 |
| Dyslipidemias | Deregulated Nutrient Sensing | In addition, the Ala12 allele of PPARgamma2 was associated with low BMI (P= 0.034) and low total triglycerides (P=0.027), and increased HDL-cholesterol (P < 0.001) in elderly subjects with dyslipidemia (n=299) but not among any other study groups. | 10924736 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance in peripheral tissues, increased hepatic gluconeogenesis, and impaired insulin secretion are the underlying factors in the development of type 2 diabetes. | 10929918 |
| Dyslipidemias | Deregulated Nutrient Sensing | Cardiac transplant patients are at increased risk of dyslipidemia, a known pathogenetic factor in chronic rejection. | 10930822 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These mice showed severe insulin resistance and glucose intolerance from an early age. | 10932232 |
| Coronary heart disease | Deregulated Nutrient Sensing | Associations between lipoprotein lipase gene polymorphisms and insulin resistance in coronary heart disease. | 10934810 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Variants of the LPL gene (Pvu II and Hind III polymorphisms) may increase the risk of developing coronary heart disease (CHD) but their effect on insulin resistance remains unknown. | 10934810 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | We suggest that the LPL gene Hind III allele might be associated with insulin resistance in nondiabetic men with CHD. | 10934810 |
| Increased insulin level, Hypertriglyceridemia, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | MMS was defined as the occurrence of two or more of either hypertension, type 2 diabetes mellitus, dyslipidemia, hypertriglyceridemia or hyperinsulinemia. | 10942873 |
| Tumor necrosis | Deregulated Nutrient Sensing | Tumor necrosis factor-alpha (TNFalpha) and its soluble receptor 2 (TNFR2) are expressed in adipose tissue and are possibly involved in the pathogenesis of insulin resistance. | 10946872 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Reduced size at birth has been proposed to be a risk factor for insulin resistance and type 2 diabetes. | 10946909 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalences of hypertension, dyslipidemia, diabetes mellitus, cigarette smoking and obesity were determined in both sexes and compared using the chi-square test. | 10951822 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The Nagoya-Shibata-Yasuda (NSY) mouse closely mimics human Type II (non-insulin-dependent) diabetes mellitus in that the onset is age-dependent, the animals are not severely obese, and both insulin resistance and impaired insulin response to glucose contribute to disease development. | 10952468 |
| Obesity | Deregulated Nutrient Sensing | Plasma leptin has been shown to correlate positively with many indices of obesity, as well as insulin resistance. | 10954026 |
| diabetic | Deregulated Nutrient Sensing | These results suggest that serum ferritin can be employed as a marker of not only glucose homeostasis but also insulin resistance both in type 2 diabetic and control subjects. | 10957894 |
| Demographics Domain, Diabetes Mellitus, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Impaired glucose tolerance (IGT) and diabetes mellitus (DM) were associated with greater insulin resistance and impaired beta-cell function compared to normal glucose tolerance (NGT). | 10963828 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Alternative training programs should be considered to maximize caloric expenditure and modify specific risk factors such as obesity and dyslipidemia. | 10966557 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The present study shows that, although the Q allele of the human glycoprotein PC-1 gene is associated with surrogate measures of insulin resistance, it may not be enough to increase the susceptibility to type 2 diabetes. | 10969847 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians. | 10969849 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, the K121Q polymorphism of the human PC-1 gene is not associated with type 2 diabetes or insulin resistance among Danish Caucasians. | 10969849 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Atorvastatin, a known substrate of the CYP3A4 pathway, is often used in combination with troglitazone for diabetic patients with dyslipidemia. | 10971778 |
| Impaired T cell function, Family history | Deregulated Nutrient Sensing | Subjects with 'both' IGT and FH had features of insulin resistance (higher BMI, systolic and diastolic blood pressure and triglyceride concentration) as well as beta cell dysfunction with a lower % B and 30 min insulin-glucose ratio compared to controls. | 10975211 |
| Atherosclerosis | Deregulated Nutrient Sensing | Cigarette smoking, environmental tobacco smoke exposure and insulin sensitivity: the Insulin Resistance Atherosclerosis Study. | 10976855 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin sensitivity and tobacco use history were measured in 1481 participants in the Insulin Resistance Atherosclerosis Study (IRAS). | 10976855 |
| Cardiovascular Diseases, Dyslipidemias, Nephrotic Syndrome, Abnormality of the peripheral nervous system, Retinal Diseases | Deregulated Nutrient Sensing | Clinical abnormalities included peripheral and central nervous system abnormalities as well as retinopathy, dyslipidemia, cardiovascular disease, and nephrotic syndrome. | 10977796 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | This article details the dyslipidemia of obesity and its cardiovascular consequences and presents some ways in which it can be managed. | 10981054 |
| Increased insulin level, Dyslipidemias, Hypertension, CTCAE, Atherosclerosis | Deregulated Nutrient Sensing | Regular physical exercise may prevent or ameliorate conditions associated with hyperinsulinemia including dyslipidemia, hypertension, and atherosclerosis in this group. | 10983904 |
| No metabolic abnormalities, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The persistence of insulin resistance and of high neutral lipid exchanges between triglyceride rich lipoproteins and HDL in insulin-treated NIDDM patients probably explain the inefficiency of insulin therapy to correct HDL apoA-I metabolic abnormalities. | 10996359 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Relations of insulin resistance and serum concentrations of estradiol and sex hormone-binding globulin to potential breast cancer risk factors. | 11011124 |
| Increased insulin level, Breast Carcinoma | Deregulated Nutrient Sensing | There is a hypothesis that hyperinsulinemia or insulin resistance may be a mediator for breast cancer risk factors. | 11011124 |
| Breast Carcinoma | Deregulated Nutrient Sensing | We also examined whether insulin resistance would explain the association of breast cancer risk factors with serum estradiol and sex hormone-binding globulin (SHBG). | 11011124 |
| Breast Carcinoma | Deregulated Nutrient Sensing | There is a possibility that effect of BMI on breast cancer risk is mediated by both insulin resistance and estrogen metabolism. | 11011124 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Furthermore, the proportionally constant participation of PI to insulin secretion observed in various stages of glucose intolerance suggests that the results obtained in the past with non specific insulin radioimmunoassays remain valid. | 11011219 |
| Uremia, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Because of the presence of dyslipidemia and the high incidence of cardiovascular and neoplastic diseases in uremic patients, we evaluated CLA and its metabolites in these patients in order to evaluate their metabolism and site distribution. | 11012903 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | These results suggest that PI could be responsible for the development of hypertriglyceridemia by a mechanism independent of insulin resistance which remains to be elucidated. | 11014386 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons. | 11018080 |
| Dyslipidemias, Adjuvant, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Adjuvant lipostabil is recommended in combined treatment of NIDDM in marked dyslipidemia, alisat--in moderate dyslipidemia. | 11019431 |
| Nephritis, Tubulointerstitial, Dyslipidemias, Lupus Nephritis | Deregulated Nutrient Sensing | This article focuses on the role of lipids in the progression of glomerular, vascular and tubulo-interstitial lesions in two patients with lupus nephritis associated with pronounced hyper- and dyslipidemia. | 11020963 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity and hypertension, the major modifiable clinical determinants of left ventricular mass, are both associated with a state of insulin resistance. | 11021954 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Further surveillance in this population is essential in verifying the impact of dyslipidemia as a risk of cardiovascular disease in Thai elderly people. | 11023086 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia were treated with similar goals in each group. | 11023140 |
| Familial generalized lipodystrophy, Myeloid Leukemia, Chronic, Autosomal recessive inheritance | Deregulated Nutrient Sensing | Congenital generalized lipodystrophy (CGL) is an autosomal recessive genetic disorder characterized by almost complete absence of adipose tissue, muscular appearance, and severe insulin resistance since birth. | 11023150 |
| Muscle Fibers, Fast-Twitch, Myeloid Leukemia, Chronic | Deregulated Nutrient Sensing | We conclude that insulin resistance in patients with CGL is associated with an increased proportion of type II muscle fibers but not reduced capillary density. | 11023150 |
| Overweight | Deregulated Nutrient Sensing | Along with genetically low postprandial insulin secretion, they are found to be less tolerable to being overweight to develop insulin resistance. | 11024579 |
| Weight Gain | Deregulated Nutrient Sensing | The body weight change in the prediabetic era consisting of 508 male patients treated on their diet alone was reviewed and it was found that a few kilograms of weight gain could be a cause of insulin resistance. | 11024579 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine whether variation in the IRS-1 gene contributes to genetic susceptibility to insulin resistance and Type 2 diabetes in Mexican Americans, the entire coding region of the IRS-1 gene was screened for variation in 31 unrelated subjects with Type 2 diabetes using single-stranded conformational polymorphism analysis (SSCP) and dideoxy sequence analysis. | 11025561 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Prevalence and phenotypic distribution of dyslipidemia in type 1 diabetes mellitus: effect of glycemic control. | 11025785 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Data on the prevalence of dyslipidemia in type 1 diabetes mellitus are scarce and are based on total triglyceride and total cholesterol concentrations alone. | 11025785 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | After glycemic optimization (mean +/- SD glycosylated hemoglobin decrease, 2.2 +/- 1.96 percentage points), the prevalence of LDL-C levels greater than 4.13 mmol/L (>160 mg/dL) became lower in diabetic men than in nondiabetic men (9.7% vs 17.5%; P =.04), but women showed frequencies of dyslipidemia similar to their nondiabetic counterparts. | 11025785 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The improvement caused by glycemic optimization puts forward intensive therapy as the initial treatment of choice for dyslipidemia in poorly controlled type 1 diabetes. | 11025785 |
| Focal glomerulosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | From retrospective studies, it has been suggested that aggressive lipid-lowering with low-density lipoprotein apheresis (LDL-A) may not only improve dyslipidemia but also decrease urinary albumin excretion and increase serum levels of albumin in patients with focal segmental sclerosis. | 11029600 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | IRS-2 inactivation in mice induces a form of diabetes characterized by peripheral insulin resistance and reduced beta cell mass. | 11030756 |
| Failure, Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | Conversely, among overweight patients there was a parallel increase in fasting plasma glucose (P for trend = 0.037) and fasting C-peptide according to the dosage of the D1057 allele, suggesting that higher insulin resistance and relative beta cell failure contributed to the increased risk of type 2 diabetes in overweight carriers of this allele. | 11030756 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The majority (74.1%) had moderate and severe grades of ED on admission to the studies, 31% had hypertension, 16% had documented coronary artery disease, 16% had dyslipidemia and 16% had diabetes. | 11035390 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate the contribution of the liver to whole-body insulin resistance in patients with type 2 diabetes mellitus, we analyzed the early decline (slope "a") in the baseline plasma glucose level following acute hyperinsulinemia in the initial phase of a euglycemic hyperinsulinemic clamp study, rather than using an isotope-dilution method. | 11036875 |
| diabetic | Deregulated Nutrient Sensing | Slope "a" was comparable among groups of diabetic and non-diabetic subjects, and did not correlate well with glucose infusion rate (GIR), an index of peripheral (primarily skeletal muscle) insulin resistance. | 11036875 |
| Obesity, diabetic | Deregulated Nutrient Sensing | In contrast, slope "a" was significantly lower in obese (BMI > 25) type 2 diabetic patients compared with their non-obese counterparts, consistent with the general belief that obesity is a condition of insulin resistance in liver as well as in peripheral tissues. | 11036875 |
| Hepatobiliary Disorder, Malignant Neoplasms, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | It is often associated with glucose intolerance, liver disease, and malignant tumors of the lungs. | 11045160 |
| Increased insulin level | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia: No independent relation to left ventricular mass in humans. | 11056098 |
| Increased insulin level, Cardiac Hypertrophy | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance may contribute to the development of cardiac hypertrophy. | 11056098 |
| Hyperinsulinism | Deregulated Nutrient Sensing | To clarify the role of insulin resistance and hyperinsulinaemia in the pathogenesis of obesity-related hypertension. | 11057433 |
| Coronary heart disease | Deregulated Nutrient Sensing | These results demonstrate that variations in concentrations of RLPs are highly correlated with changes in sigmaIRI, consistent with the possibilities that 1) RLP measurements are useful estimates of insulin resistance; and 2) an increase in RLP concentrations may provide the mechanistic link between insulin resistance and coronary heart disease. | 11061501 |
| Microunit per Milliliter | Deregulated Nutrient Sensing | Lipodystrophic children had higher fasting insulinaemia (7.0+/-8.5 versus 3.0+/-2.3 microU/ml; P = 0.07), suggesting a certain degree of insulin-resistance. | 11061653 |
| Lipodystrophy, Dyslipidemias | Deregulated Nutrient Sensing | Insulin-resistance occurs in lipodystrophic children only, whereas dyslipidaemia exists in non-lipodystrophic children as well, suggesting that dyslipidaemia could reflect subclinical alteration of the adipose tissue. | 11061653 |
| Lipodystrophy, Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Hypercholesterolaemia (23% versus 15%; P = 0.59 ) and hypertriglyceridaemia (15% versus 11%; P = 0.76) were observed with the same proportion in the lipodystrophic as in the non-lipodystrophic groups; 23% of the non-lipodystrophic children had dyslipidaemia. | 11061653 |
| Breast Carcinoma, Hirsutism, Italy | Deregulated Nutrient Sensing | Markers of insulin resistance and sex steroid hormone activity in relation to breast cancer risk: a prospective analysis of abdominal adiposity, sebum production, and hirsutism (Italy). | 11065009 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Insulin resistance and increased levels of serum steroids have been hypothesized to be relevant etiological factors for breast cancer. | 11065009 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Measurements of markers of insulin resistance and elevated serum steroids may identify women at high risk for breast cancer. | 11065009 |
| Hirsutism, Breast Carcinoma | Deregulated Nutrient Sensing | The present study analyzed the association of breast cancer with markers of insulin resistance and elevated serum sex steroids, abdominal adiposity, increase in sebum production and hirsutism in a case-control study nested in a prospective cohort study. | 11065009 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The results also indicate a central activation of the sympathetic nervous system, such as in the early phases of hypertension, correlating with insulin resistance. | 11068954 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Interaction between the Asn291Ser variant of the LPL gene and insulin resistance on dyslipidaemia in high risk individuals for Type 2 diabetes mellitus. | 11073182 |
| Dyslipidemias, Cardiovascular Diseases, lipoprotein disorder | Deregulated Nutrient Sensing | A genetic variant of the LPL gene on chromosome 8p22, Asn291Ser, has previously been associated with dyslipidaemia and an increased frequency of cardiovascular disease as well as familial disorders of lipoprotein metabolism. | 11073182 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The frequency of the Asn/Ser genotype was significantly increased in normoglycaemic subjects with hypertriglyceridaemia (> 1.7 mmol/1), and was associated with dyslipidaemia and increased systolic blood pressure. | 11073182 |
| Prostate Cancer Outcomes Study, Endocrine System Diseases, Obesity, Hyperandrogenism, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder characterized by obesity, hyperandrogenism, and insulin resistance. | 11073846 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | To investigate the safety and efficacy of niacin in daily doses of 1.5 and 3.0 g in patients with ischemic heart disease and dyslipidemia. | 11075282 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Niacin is a safe, effective and a low cost alternative in the treatment of patients with ischemic heart disease and dyslipidemia. | 11075282 |
| Lipoatrophic Diabetes Mellitus, Insulin resistance syndrome | Deregulated Nutrient Sensing | Lipoatrophic diabetes mellitus is a rare insulin-resistance syndrome. | 11077638 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In middle-aged siblings of patients with type 2 diabetes mellitus normal glucose tolerance is associated with insulin resistance and with increased insulin secretion. | 11078993 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis. | 11079812 |
| Increased insulin level, Glucose Intolerance (disease), Depression, CTCAE | Deregulated Nutrient Sensing | A high proportion of patients with depression develop glucose intolerance accompanied by hyperinsulinemia, suggestive of reduced insulin sensitivity (insulin resistance). | 11079812 |
| Carcinogenesis | Deregulated Nutrient Sensing | This observation illustrates the multistep process of carcinogenesis in the non-cirrhotic liver and raises the question of i) the origin of this iron overload possibly linked to insulin resistance syndrome and ii) the role of iron as a co-carcinogen. | 11084432 |
| Increased insulin level, Muscle (organ) | Deregulated Nutrient Sensing | According to our hypothesis, muscle loss allows for the full expression of hyperinsulinemia and insulin resistance, which allows the fuel previously directed to the muscle to be deposited as adipose tissue. | 11090303 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The known metabolic cardiovascular disease risk factors associated with insulin resistance syndrome (IRS) do not adequately explain the excess cardiovascular disease risk attributed to this syndrome, and abnormalities in hemostatic variables may contribute to this excess risk. | 11092431 |
| Tumor necrosis | Deregulated Nutrient Sensing | Given that the NcoI polymorphism of the tumor necrosis factor-beta (TNF-beta) gene has been shown to be associated with tumor necrosis factor-alpha (TNF-alpha) secretory capacity, we know that this TNF-beta gene polymorphism may influence insulin resistance. | 11092520 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Leptin, an adipose tissue-derived product of the obesity (OB) gene, is an important regulator of energy metabolism and may be associated with the occurrence of insulin resistance and diabetes in humans. | 11093287 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Insulin resistance syndrome in childhood, characterized by high blood pressure, dyslipidemia, and hyperinsulinemia, may be an early marker of cardiovascular risk. | 11093287 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Obese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle. | 11093291 |
| diabetic | Deregulated Nutrient Sensing | Hybrid receptors (HRs), insulin receptor (IR)/insulin-like growth factor I receptor (IGF-I-R) heterodimers have been reported increased in skeletal muscle of obese and type 2 diabetic patients and to contribute to the patient insulin resistance. | 11095457 |
| Obesity | Deregulated Nutrient Sensing | To investigate whether or not the increased expression of hybrid receptors is an early defect (probably genetic) of insulin resistance, we measured by specific enzyme-linked immunosorbent assays both IR, IGF-I-R, and HR content in skeletal muscle of healthy nonobese, nondiabetic subjects either insulin sensitive or insulin resistant, and also in patients with moderate obesity. | 11095457 |
| Thrombosis, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors like hypertension, diabetes mellitus, dyslipidemia and smoking contribute to the pathogenesis of atherothrombosis. | 11111140 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | It is hypothesized that these impairments in fatty acid utilization may play a role in the etiology of skeletal muscle and hepatic insulin resistance. | 11118013 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | We estimated risk for type 2 diabetes and milder degrees of glucose intolerance associated with parental diabetes among subjects of the population-based Framingham Offspring Study, in which participants are primarily Caucasian and at relatively low risk for diabetes and for which both parental and offspring phenotypes were ascertained by direct examination. | 11118026 |
| Glucose Intolerance (disease), Diabetes Mellitus, diabetic | Deregulated Nutrient Sensing | For maternal diabetes to confer excess risk for mild but not overt glucose intolerance, offspring of diabetic fathers may transit abnormal to impaired glucose tolerance relatively quickly, or diabetic mothers may transmit risk for a mild slowly progressive form of abnormal glucose tolerance in addition to overt diabetes. | 11118026 |
| Hyperglycemia, HEPATIC LIPASE DEFICIENCY (disorder) | Deregulated Nutrient Sensing | min(-1) or 60.4 vs. 51.4% of EGP, P < 0.02), GNG was within normal limits (less than the mean +/- 2 SD of controls or <65.3%) in 11/14 (79%) patients with mild to moderate hyperglycemia (FPG <10 mM) and in 5/13 (38%) of patients with severe hyperglycemia (FPG 10-20 mM); 3) that elevated GNG in T2DM was associated with a 43% decrease in prehepatic insulin secretion, i.e., with hepatic insulin deficiency; and 4) that FPG correlated significantly with glucose clearance (insulin resistance) (r = 0.70) and with GNG (r = 0.50) or EGP (r = 0.45). | 11120655 |
| Hyperglycemia, HEPATIC LIPASE DEFICIENCY (disorder) | Deregulated Nutrient Sensing | We conclude 1) that peripheral insulin resistance is at least as important as GNG (and EGP) as a cause of postabsorptive hyperglycemia in T2DM and 2) that GNG and EGP in T2DM are increased under conditions of significant hepatic insulin deficiency and thus probably represent a late event in the course of T2DM. | 11120655 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These findings offer a potential mechanistic explanation of the links among insulin resistance, impaired insulin-mediated vasodilatation and hypertension. | 11121808 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | The displayed lipid profile is also known as the atherogenic profile and is associated with insulin resistance, type 2 diabetes mellitus, and an increased risk of cardiovascular disease. | 11127274 |
| Triglycerides, diabetic | Deregulated Nutrient Sensing | Remnant-like particle cholesterol, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients. | 11128349 |
| diabetic | Deregulated Nutrient Sensing | Univariate regression analysis showed that insulin resistance was positively correlated with BMI (r = 0.254, P = 0.019), HbA1c levels (r = 0.278, P = 0.011), RLP cholesterol levels (r = 0.315, P = 0.004), and triglyceride levels (r = 0.332, P = 0.002) and was negatively correlated with HDL cholesterol levels (r = -0.301, P = 0.006) in our diabetic patients. | 11128349 |
| diabetic | Deregulated Nutrient Sensing | Multiple regression analysis showed that insulin resistance was independently associated with serum triglyceride levels, which explained 13.5% of the variability of insulin resistance in our nonobese Japanese type 2 diabetic patients. | 11128349 |
| diabetic | Deregulated Nutrient Sensing | These results indicate that 1) nonobese Japanese type 2 diabetic patients with insulin resistance are characterized by high RLP cholesterol and triglyceride levels, and low HDL cholesterol levels; and 2) the level of serum triglycerides is an independent predictor of insulin resistance in these patients. | 11128349 |
| macroangiopathy, Hyperhomocysteinemia, Diabetes Mellitus, Non-Insulin-Dependent, Kidney Diseases | Deregulated Nutrient Sensing | Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance. | 11128359 |
| macroangiopathy, Diabetes Mellitus, Non-Insulin-Dependent, Kidney Diseases | Deregulated Nutrient Sensing | Elevated plasma tHcy levels in type 2 diabetes is associated with a higher prevalence of macroangiopathy and nephropathy when assessed from creatinine clearance indexes and is not associated with different degrees of insulin resistance. | 11128359 |
| Microalbuminuria | Deregulated Nutrient Sensing | Risk variables of insulin resistance syndrome in African-American and Caucasian young adults with microalbuminuria: the Bogalusa Heart Study. | 11130771 |
| Microalbuminuria | Deregulated Nutrient Sensing | These results suggest that microalbuminuria is not necessarily an intrinsic component of the insulin resistance syndrome, at least in the young adult age. | 11130771 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of Type 2 diabetes mellitus was very high especially in older subjects, and fibrinogen was associated with increasing glucose intolerance in men but not in women. | 11131105 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The clustering of hypertension, insulin resistance, and obesity remains unexplained. | 11136689 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Clustering of hypertension and insulin resistance in Hispanic Americans is accounted for in part by heritable factors both associated with and independent of BMI. | 11136689 |
| Peripheral Vascular Diseases, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The only significant differences were a higher prevalence of peripheral vascular disease and dyslipidemia in the diabetic group and a higher prevalence of hemispheric transient ischemic attacks among the nondiabetic patients. | 11137935 |
| Dyslipidemias, Vascular Diseases, Nephrotic Syndrome, Hypertension, CTCAE | Deregulated Nutrient Sensing | Many other factors--linked to the time of TP--may be involved in vascular diseases, such as nephrotic syndrome, dyslipidemia, hypertension and drugs. | 11140810 |
| Obesity, diabetic | Deregulated Nutrient Sensing | In conclusion, no major difference was associated with TNF1 and TNF2 polymorphisms in terms of obesity, blood pressure, lipids, or glucose in young, older, or diabetic Japanese men, although FPG was significantly higher in older men, possibly through increased insulin resistance. | 11145126 |
| Retinal Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Additional adjustment for baseline insulin resistance, blood pressure, body mass index, presence of cardiovascular disease and retinopathy, current smoking, or estimates of glomerular filtration rate did not materially affect the results. | 11145936 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Major determinants of fasting triglycerides, namely, diabetes, obesity, other factors related to insulin resistance, and male sex, were not independently associated with postprandial responses. | 11156865 |
| Obesity | Deregulated Nutrient Sensing | The independent atherogenic influence of postprandial lipids may relate more to smoking and diet than to obesity and insulin resistance. | 11156865 |
| Dyslipidemias, HIV, HMGA2 Protein | Deregulated Nutrient Sensing | Human immunodeficiency virus (HIV) lipodystrophy (LIPO) is characterized by increased visceral adiposity, peripheral fat atrophy, dyslipidemia, and insulin resistance. | 11158000 |
| Kidney Failure, Chronic, Cardiovascular morbidity, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is common in end-stage renal disease (ESRD), and hemodialysis patients have increased cardiovascular morbidity and mortality. | 11158861 |
| Sepsis, Hypermetabolism, Traumatic injury | Deregulated Nutrient Sensing | Patients with sepsis and trauma are characterised by hypermetabolism, insulin resistance and protein catabolism. | 11161543 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It is not related to dyslipidemia or diabetes. | 11165964 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Four had acanthosis nigricans which is a cutaneous marker of insulin resistance and the other four had high plasma levels of insulin and/or C peptide. | 11168330 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Concordance between fasting and 2-h post-glucose challenge criteria for the diagnosis of diabetes mellitus and glucose intolerance in high risk individuals. | 11168338 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The new lower fasting criteria might be too insensitive to identify a large proportion of individuals with diabetes or impaired glucose intolerance, particularly in a high-risk population. | 11168338 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Maximal post-prandial triglyceride increase reflects post-prandial hypertriglyceridaemia and is associated with the insulin resistance syndrome. | 11168339 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | To assess the value of maximal post-prandial triglyceride increase after a high fat, low carbohydrate (CHO) test meal, as index of post-prandial hypertriglyceridaemia and its relation with insulin resistance. | 11168339 |
| Left Ventricular Hypertrophy, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | -Dyslipidemia and indices of a low dietary intake of linoleic acid and high intake of saturated and monounsaturated fats, as well as hypertension and obesity, at age 50 predicted the prevalence of LVH 20 years later in this prospective longitudinal cohort study, thereby suggesting that lipids may be important in the origin of LVH. | 11171792 |
| Elevated diastolic blood pressure, Obesity | Deregulated Nutrient Sensing | These cases and a small LDL peak particle size were characterized by the features of the insulin resistance syndrome, ie, general and central obesity, elevated diastolic blood pressure, low serum concentrations of high-density lipoprotein (HDL) and apolipoprotein A1 (apoA1), increases in serum triglycerides and circulating insulin peptides, and low insulin-mediated glucose uptake. | 11172485 |
| Microalbuminuria | Deregulated Nutrient Sensing | The underlying linkage might be microalbuminuria and insulin resistance. | 11189206 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | The most important risk factor was smoking (60%) followed by dyslipidaemia (47%) and family history of coronary artery disease (20%). | 11194015 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | How cost-effective is the treatment of dyslipidemia in patients with diabetes but without cardiovascular disease? | 11194239 |
| diabetic | Deregulated Nutrient Sensing | Gender-related difference in relationship between insulin resistance and serum leptin level in Japanese type 2 diabetic and non-diabetic subjects. | 11200943 |
| diabetic | Deregulated Nutrient Sensing | To investigate the possible existence of an independent correlation, we have assessed serum leptin levels and insulin resistance in Japanese diabetic and non-diabetic subjects by means of Homeostatic Model Assessment (HOMA-R). | 11200943 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | Insulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake. | 11204310 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | This study was designed to see if insulin resistance in hypertensives, measured using the HOMA index, differs, based on salt sensitivity, renin status and sodium intake. | 11204310 |
| Hyperandrogenism | Deregulated Nutrient Sensing | A radical modification in diet designed to reduce insulin resistance and also involving increased phytoestrogen intake decreases the bioavailability of serum sex hormones in hyperandrogenic postmenopausal women. | 11205485 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Our data suggest that, similar to Type II (non-insulin-dependent) diabetes mellitus, the metabolic burden of obesity and insulin resistance could preferentially precipitate postpubertal clinical onset in male subjects with slowly progressive subclinical (immune-mediated) diabetes. | 11206410 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance (IR) in older individuals is associated with risk factors for coronary artery disease. | 11213873 |
| Retinal Diseases | Deregulated Nutrient Sensing | Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes. | 11213880 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes. | 11213893 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | HOMA-IR may constitute a useful method not only for diagnosing insulin resistance, but also for follow-up during the treatment of patients with type 2 diabetes. | 11213893 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | The combination of atorvastatin with micronised fenofibrate in patients with severe mixed dyslipidemia may have a favourable effect on some major coronary artery disease risk factors. | 11214768 |
| Hypoglycemia, Autoimmune reaction | Deregulated Nutrient Sensing | Insulin receptor antibodies can induce severe hypoglycemia or insulin resistance in rare autoimmune syndromes. | 11217151 |
| Impaired cognition, Feeling powerless, Edema, Glucose Intolerance (disease), Behavioral tic | Deregulated Nutrient Sensing | Chronic stress also induced glucose intolerance, suppressed male sexual behaviour, induced behavioural depression (Porsolt's swim despair test and learned helplessness test) and cognitive dysfunction (attenuated retention of learning in active and passive avoidance tests), and immunosuppression (leucocyte migration inhibition and sheep RBC challenged increase in paw oedema in sensitized rats). | 11218827 |
| Dyslipidemias | Deregulated Nutrient Sensing | In patients with mixed dyslipidemia, fluvastatin ER 80 mg reduced triglycerides by 21.8% (median 28%) and increased HDL-C by 14.5%. | 11219479 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with type 2 diabetes and hypertension constitute a high risk category with a more atherogenic risk factor profile related to the insulin resistance syndrome. | 11220508 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | A study of the influence of insulin resistance on left ventricular mass in hypertensive patients. | 11229109 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | To study the influence of insulin resistance on the left ventricular mass in hypertensive subjects. | 11229109 |
| Increased insulin level, Hypertension, CTCAE, Ventricular hypertrophy | Deregulated Nutrient Sensing | Thus, in patients with essential hypertension, hyperinsulinemia (insulin resistance) has a role in promoting left ventricular hypertrophy. | 11229109 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The new thiazolidinedione drugs such as troglitazone which increase insulin sensitivity in patients with glucose intolerance and diabetes, may be very useful in cases where insulin resistance has resulted in diabetes. | 11229192 |
| Apolipoprotein E, Hypertriglyceridemia | Deregulated Nutrient Sensing | The present study was undergone to establish whether apolipoprotein C-III (apoC-III) and apolipoprotein E (apoE) associated with apo B (apoC-III LpB and apoE LpB, respectively), considered to be markers of remnant accumulation, play a role in the hypertriglyceridemia associated with insulin resistance and whether they are related to other biological abnormalities frequently observed in this syndrome. | 11231921 |
| Corneal Endothelial Cell Loss | Deregulated Nutrient Sensing | Markers of the endothelial damage, plasminogen activator inhibitor-1, tissue plasminogen activator, and von Willebrand factor, which are often increased in the case of insulin resistance, were tested for their correlation with the markers of remnant accumulation. | 11231921 |
| Obesity | Deregulated Nutrient Sensing | Increased total and intraabdominal fat (IAF) obesity as well as other metabolic conditions associated with the insulin resistance syndrome (IRS) are related to low levels of sex hormone-binding globulin (SHBG) in young and older Caucasian (CAU) and young African-American (AA) women. | 11231984 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | These data support the physiologic relevance of the GL as a potential risk factor for coronary artery disease in free-living women, particularly those prone to insulin resistance. | 11237932 |
| Obesity | Deregulated Nutrient Sensing | Although obesity is often associated with insulin resistance and a cluster of metabolic disturbances, the existence of a subgroup of healthy but obese individuals has been postulated. | 11238480 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Under these circumstances they develop high rates of obesity, insulin resistance and type 2 diabetes. | 11238781 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | White blood cell count and insulin resistance in patients with coronary artery disease. | 11240402 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Patients with glucose intolerance, arterial hypertension or obesity were excluded. | 11240402 |
| Hypertensive (finding), Hypertension, CTCAE, Endothelial dysfunction | Deregulated Nutrient Sensing | Insulin resistance adds to endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. | 11240849 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Endothelial dysfunction is related to hyperinsulinaemia/insulin resistance, which could be one of the pathogenetic determinants of EH and its complications. | 11240849 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum insulin, proinsulin and proinsulin/insulin ratio in type 2 diabetic patients: as an index of beta-cell function or insulin resistance. | 11242807 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | Although insulin resistance and decreased insulin secretion are characteristics of established type 2 DM, which of these metabolic abnormalities is the primary determinant of type 2 DM is controversial. | 11242807 |
| Impaired T cell function | Deregulated Nutrient Sensing | It is also not well known how insulin resistance and beta cell dysfunction influence serum insulin, proinsulin, proinsulin/insulin ratio in type 2 DM. | 11242807 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Physical activity may have both a preventive effect and a secondary preventive effect of lessening insulin resistance in persons with type 2 diabetes. | 11249259 |
| Hypercholesterolemia, Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Fibrinolytic parameters and insulin resistance in young survivors of myocardial infarction with heterozygous familial hypercholesterolemia. | 11253736 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Patients with previous myocardial infarction had significantly higher levels of insulin, insulin resistance, triglycerides, t-PA antigen, PAI-1 antigen and activity, and significantly lower values of HDL cholesterol. | 11253736 |
| Premature coronary artery atherosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | The kindred was ascertained for premature coronary heart disease and was expanded based on familial dyslipidemia. | 11260209 |
| Weight Gain | Deregulated Nutrient Sensing | The insulin resistance caused by olanzapine is normally attributed to the weight gain associated with the drug. | 11261526 |
| Dyslipidemias, Liver Dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Biochemistry and oral glucose tolerance tests showed diabetes mellitus, dyslipidemia, and hepatic dysfunction in the index case. | 11265260 |
| Increased insulin level, Hyperglycemia | Deregulated Nutrient Sensing | At present, the patient presents severe hyperglycemia and hyperinsulinemia with a marked insulin resistance. | 11265632 |
| Low-Density Lipoproteins, Coronary Artery Disease | Deregulated Nutrient Sensing | Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men. | 11266194 |
| Glucose Intolerance (disease), Coronary Artery Disease, Hyperlipoproteinemias | Deregulated Nutrient Sensing | Visceral fat accumulation plays an important role in the occurrence of coronary artery disease (CAD) associated with a cluster of multiple risk factors, such as glucose intolerance, insulin resistance and hyperlipoproteinemia. | 11266194 |
| Nonalcoholic Steatohepatitis, Mitochondrial abnormalities | Deregulated Nutrient Sensing | Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. | 11266382 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | We tested the hypothesis that NASH is associated with 2 defects: (1) peripheral insulin resistance, which increases lipolysis, delivery of free fatty acids (FFA) to the liver, and hepatic fatty acid beta oxidation, thereby creating oxidative stress; and (2) an abnormality within the hepatocytes that might render them more susceptible to injury from oxidative stress. | 11266382 |
| Fatty Liver, Fatty Liver Disease | Deregulated Nutrient Sensing | NASH and fatty liver were both associated with insulin resistance, with mean glucose infusion rates (normal/fatty liver/NASH) of step 1, 4.5/1.6/0.9; step 2, 9.5/7.7/4.5 (P < 0.03 for both steps). | 11266382 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | These data indicate that peripheral insulin resistance, increased fatty acid beta oxidation, and hepatic oxidative stress are present in both fatty liver and NASH, but NASH alone is associated with mitochondrial structural defects. | 11266382 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results suggest that insulin resistance per se is a significant risk factor for CAD in Japanese patients with type 2 diabetes. | 11269890 |
| Diabetes Mellitus, Cerebrovascular accident | Deregulated Nutrient Sensing | Is insulin resistance or diabetes mellitus associated with stroke? | 11269894 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and/or diabetes are risk factors for coronary artery disease. | 11269894 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | The prescription of statins in patients with coronary artery disease and dyslipidemia is high; however, its adherence is far from satisfactory, due to the high cost of the medication. | 11270314 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In this study we tested PTEN as a candidate gene for insulin resistance and late-onset Type II (non-insulin-dependent) diabetes mellitus in a Danish Caucasian population. | 11270682 |
| Dyslipidemias, Depression, CTCAE | Deregulated Nutrient Sensing | Despite increasing evidence of an association between lower cholesterol levels and negative mood, no study has specifically investigated this relationship in obese people, a population at high risk for both dyslipidaemia and depression. | 11274685 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In this program, we evaluated the effects of a combination of exercise training and a diet on cardiovascular risk factors such as obesity, dyslipidemia, and poor exercise performance in obese subjects. | 11279836 |
| Weight decreased, Dyslipidemias | Deregulated Nutrient Sensing | A combination of aerobic exercise and a mild hypocaloric diet significantly contributed not only to weight loss but also to the improvement of dyslipidemia and exercise performance, but either hypocaloric diet or mild exercise independently did less. | 11279836 |
| Hyperglycemia, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The purpose of the present article is to report on the influence of hyperglycemia on the left ventricular diastolic dysfunction independently of dyslipidemia, obesity, and systemic arterial hypertension, usually present in diabetic patients. | 11282180 |
| Diastolic dysfunction, Hyperglycemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Independently of dyslipidemia and obesity, a relationship was found between hyperglycemia and diastolic dysfunction of the left ventricle in patients belonging to group A (p <0.05, odds ratio [OR] 12.1). | 11282180 |
| Gout | Deregulated Nutrient Sensing | Increased visceral fat accumulation further aggravates the risks of insulin resistance in gout. | 11288032 |
| Gout | Deregulated Nutrient Sensing | Gout patients possess some factors that are included in the insulin resistance syndrome, irrespective of the presence of VFO, and the insulin resistance risk factors observed in gout become more prominent when it is complicated with VFO. | 11288032 |
| Dyslipidemias | Deregulated Nutrient Sensing | Monotherapy with sulfonylurea may result in the exhaustion of pancreatic beta-cell function, fat accumulation, and dyslipidemia. | 11288035 |
| Obesity | Deregulated Nutrient Sensing | The beta(3)-adrenergic receptor (AR) gene variant (Trp64Arg) has been reported to be associated with obesity and insulin resistance in humans. | 11288039 |
| diabetic | Deregulated Nutrient Sensing | From these results, it can be concluded that bezafibrate reduces serum triglycerides, insulin resistance, and fasting blood glucose levels in non-obese Japanese type 2 diabetic patients. | 11288046 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The insulin resistance state is common in humans and animals with chronic renal failure. | 11288821 |
| Dyslipidemias, Coronary Artery Disease, Coronary Artery Vasospasm | Deregulated Nutrient Sensing | Dyslipidemia in patients with coronary vasospasm has been characterized by a low level of high-density lipoprotein (HDL) cholesterol without elevation of low-density lipoprotein (LDL) cholesterol, distinct from patients with organic coronary artery disease. | 11288968 |
| Dyslipidemias, Coronary Artery Vasospasm | Deregulated Nutrient Sensing | The midband lipoprotein was frequently detected in patients with coronary vasospasm, suggesting that dyslipidemia with disordered triglyceride-rich lipoprotein metabolism may be linked to the genesis of coronary artery spasm. | 11288968 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings support a role for the PPAR-gamma2 Pro12Ala variant in the etiology of type 2 diabetes and the insulin resistance syndrome. | 11289057 |
| Cessation of life, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Subclinical states of glucose intolerance and risk of death in the U.S. | 11289466 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although clinically evident type 2 diabetes is a well-established cause of mortality, less is known about subclinical states of glucose intolerance. | 11289466 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The results show that 74.1% of patients had moderate or severe grades of ED on inclusion into the studies, 31% had hypertension, 16% had documented coronary artery disease, 16% had dyslipidemia, and 16% had diabetes. | 11289567 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Further, an increase of insulin resistance and development of non-insulin-dependent diabetes mellitus has been described after treatment with IFN-alpha. | 11293453 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Maximum mean increases in HDL-C level (21%) and median decreases in TG level (31%) with fluvastatin XL 80 mg HS occurred in patients with type IIb dyslipidemia and the highest baseline TG. | 11293552 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia in type 2 diabetes has been shown to be related to the incidence of macrovascular events. | 11293949 |
| Angina Pectoris | Deregulated Nutrient Sensing | The + allele, by influencing iNOS expression, could thus contribute to indices of insulin resistance and angina severity in male CAD patients. | 11294696 |
| Obesity, Muscle (organ) | Deregulated Nutrient Sensing | These results suggest that RT may be useful in ameliorating insulin resistance that often occurs with physical inactivity, obesity, and loss of muscular strength in older insulin resistant men and women. | 11300234 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | High intake of refined carbohydrates and markers of insulin resistance are associated with colorectal cancer. | 11300319 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Possession of the coagulation factor XIII Val34Leu (FXIIIVal34Leu) polymorphism is associated with protection against myocardial infarction (MI) in Caucasians, in the absence of features of insulin resistance. | 11307805 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | The role of this polymorphism in the UK Asian population, with its high prevalence of insulin resistance and ischaemic heart disease, is unknown. | 11307805 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | FXIII B-subunit levels are strongly linked to risk factors for cardiovascular disease, suggesting an underlying association with insulin resistance. | 11307805 |
| Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus. | 11311966 |
| Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We analyzed serum concentrations of tumor necrosis factor-alpha (TNF-alpha) for their role in insulin resistance in 12 obese men with untreated Type 2 diabetes mellitus and in 6 age-and BMI-matched obese controls. | 11311966 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These data suggest that high levels of serum TNF-alpha in patients with insulin resistance are related to high levels of fasting insulin and HOMA-R. We conclude that TNF-alpha may be involved in the pathogenesis of Type 2 diabetes mellitus in obese men. | 11311966 |
| Microalbuminuria, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Microalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population. | 11311969 |
| Increased insulin level, Microalbuminuria, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | These results show that microalbuminuria in the Korean general population is associated with hyperinsulinemia and central obesity, and suggest that microalbuminuria is a feature of the insulin resistance syndrome independent of hypertension or type 2 diabetes. | 11311969 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence and determinants of diabetes mellitus and glucose intolerance in a Canarian Caucasian population - comparison of the 1997 ADA and the 1985 WHO criteria. | 11318846 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes mellitus and glucose intolerance in Guia is one of the highest among studied Caucasian populations. | 11318846 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | [J-curve between alcohol consumption and carotid atherosclerosis in patients with dyslipidemia]. | 11322030 |
| Thrombus, Hypertensive (finding) | Deregulated Nutrient Sensing | These parameters described a prothrombotic state associated with an insulin resistance state, an increased vWF release, raised sP-Sel and TNFalpha levels and, maybe, low NO bioavailability, which could lead to a higher risk of development of thrombotic events in hypertensive diabetic patients (Group A) than in the hypertensive patients in Group B. | 11323020 |
| Hyperglycemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperglycemia related to insulin resistance in hypertension in Tanzania is associated with increased urinary 8-OHdG. | 11327625 |
| Apolipoproteins B, Glucose Intolerance (disease), Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Glucose intolerance was present in about one-half the recipients and was associated with age, a positive family history of ischaemic heart disease, acute rejection, higher levels of serum triglycerides, apolipoprotein B and 2-h insulin, and lower levels of serum HDL cholesterol. | 11328915 |
| Apolipoproteins B, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | After adjustment for age and sex, lower HDL cholesterol (P=0.005), higher serum triglycerides (P<0.001), apolipoprotein B (P=0.039) and 2-h insulin (P<0.001) were still associated with post-transplant glucose intolerance. | 11328915 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Traditional risk factors like hypertension, dyslipidaemia and diabetes mellitus are common, but cannot completely account for the high prevalence of CVD in this population. | 11328915 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The treatment of obesity and insulin resistance in adults often proves ineffective because the vicious cycle leading to type 2 diabetes may have become entrenched and, to some extent, may be irreversible. | 11335776 |
| Weight Gain, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Early detection and therapy of the obese adolescent with a family history of type 2 diabetes may interrupt the cycle of weight gain and insulin resistance that leads to glucose intolerance in adulthood. | 11335776 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | We reasoned that drugs that increase glucose tolerance in diabetic patients might prove useful in preventing the progression to glucose intolerance in high-risk patients. | 11335776 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertension, dyslipidemia and overweight contribute substantially to cardiovascular disease risk. | 11340101 |
| Cerebrovascular Disorders | Deregulated Nutrient Sensing | Insulin resistance and elevated levels of tissue plasminogen activator in first-degree relatives of South Asian patients with ischemic cerebrovascular disease. | 11340211 |
| Increased insulin level, Cerebrovascular accident | Deregulated Nutrient Sensing | South Asians stroke relatives exhibit hyperinsulinemia, increased insulin resistance, and increased tissue plasminogen activator levels. | 11340211 |
| Atherosclerosis, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The common insulin resistance syndrome, with obesity, dyslipidemia, hyperglycemia, and hypertension, is associated with increased risk of atherosclerosis. | 11342468 |
| Atherosclerosis | Deregulated Nutrient Sensing | Early atherosclerosis in rare monogenic forms of insulin resistance, however, has not been extensively documented. | 11342468 |
| LMNA wt Allele | Deregulated Nutrient Sensing | All LMNA mutation carriers had FPLD with insulin resistance. | 11342468 |
| LMNA wt Allele, Increased insulin level, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Rare LMNA mutations that underlie FPLD with insulin resistance and hyperinsulinemia are also associated with early CHD, notably in women. | 11342468 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | This suggests that abnormalities of the nuclear envelope can result in a phenotype that recapitulates most of the important attributes of the common insulin resistance syndrome, including accelerated cardiovascular disease. | 11342468 |
| LMNA wt Allele | Deregulated Nutrient Sensing | FPLD thus appears to be an appropriate human monogenic model for the common insulin resistance syndrome. | 11342468 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | In addition, LMNA mutation carriers had significantly more type 2 diabetes, hypertension, and dyslipidemia than normal family control subjects. | 11342468 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to ascertain whether the presence of hypertension conveys a more severe degree of insulin resistance in type 2 diabetes mellitus and, if so, which biochemical pathways are involved. | 11344209 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | These results indicate that hypertension markedly aggravates insulin resistance featuring type 2 diabetes mellitus. | 11344209 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Glucocorticoid excess frequently results in obesity, insulin resistance, glucose intolerance, and hypertension and may be the product of altered glucocorticoid hormone action. | 11344242 |
| Hypertensive (finding), diabetic | Deregulated Nutrient Sensing | This applies not only to postmenopausal women, elderly people, obese and diabetic subjects, hypertensive subjects with insulin resistance but also to young subjects. | 11344644 |
| Weight Gain | Deregulated Nutrient Sensing | Although the mechanism is not yet known, it has been hypothesized that perhaps damage to the pancreatic islet cells, weight gain, dysregulation of the sympathetic system, and insulin resistance are contributing factors. | 11346063 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Prevalence of type 2 diabetes mellitus and glucose intolerance in the Setif area (Algeria)]. | 11353884 |
| Dyslipidemias | Deregulated Nutrient Sensing | Women who developed IFG during the menopausal transition exhibited significantly higher levels of body fatness and dyslipidemia, premenopausally, compared with the women who did not develop IFG. | 11360146 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The occurrence of obesity and dyslipidemia was relatively high in the Aymara population, although the frequency of sedentary habits, and the prevalence of hypertension were low. | 11369169 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Setback in insulin resistance has been described in patients with essential hypertension. | 11374224 |
| Dyslipidemias | Deregulated Nutrient Sensing | High-flux hemodialysis has been reported to attenuate renal dyslipidemia. | 11374763 |
| Calcification of coronary artery, Cardiovascular Diseases | Deregulated Nutrient Sensing | Reduced heart-rate variability clusters with other cardiovascular disease risk factors, especially those that are more common in the insulin resistance syndrome, and is associated with increased coronary calcification in asymptomatic young adults. | 11375379 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Efficacy of atorvastatin in achieving National Cholesterol Education Program low-density lipoprotein targets in women with severe dyslipidemia and cardiovascular disease or risk factors for cardiovascular disease: The Women's Atorvastatin Trial on Cholesterol (WATCH). | 11376309 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | We have determined the efficacy and frequency of achieving target levels for LDL-C with atorvastatin on the basis of National Cholesterol Education Program Adult Treatment Panel II recommendations in 318 women according to the presence of CVD (198 women) or risk factors for CVD (120 women) and the presence of mixed dyslipidemia with obesity with or without CVD (72 women). | 11376309 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The presence of mixed dyslipidemia with obesity did not affect the frequency of achieving LDL-C targets. | 11376309 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | The concordance rates for glucose intolerance, overall obesity and low HDL-cholesterol were significantly higher among monozygotic than dizygotic twins indicating a genetic influence on the development of these phenotypes. | 11380071 |
| Neoplasms | Deregulated Nutrient Sensing | Loss of body weight after removal of the tumor correlated with a dramatic reduction of insulin resistance to such a degree that diet alone proved sufficient for satisfactory glycemic control. | 11388080 |
| Obesity | Deregulated Nutrient Sensing | Endothelin-1 levels are not related to blood pressure, but are higher in healthy young men with insulin resistance and obesity. | 11391030 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | A number of risk factors have been identified in young and middle-aged adults, such as dyslipidemia, hypertension and diabetes. | 11393007 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | In conclusion, dyslipidaemia in patients with HIV infection was significantly associated with adherence to PI-containing antiretroviral therapy. | 11394983 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | So far, it is not clear if increased cholesterogenesis in type 2 diabetes is related to the degree of glycemic control or depends on the commonly associated dyslipidemia or both. | 11395032 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Smoking, Atherosclerosis | Deregulated Nutrient Sensing | Smoking is associated with increased hepatic lipase activity, insulin resistance, dyslipidaemia and early atherosclerosis in Type 2 diabetes. | 11395034 |
| Dyslipidemias, Atherosclerosis, diabetic | Deregulated Nutrient Sensing | We have studied the relationships between hepatic lipase activity, smoking, dyslipidaemia insulin resistance, and early atherosclerosis in 67 Type 2 diabetic subjects, 47 non-smokers and 20 smokers. | 11395034 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We suggest that smoking accentuates the dyslipidaemia of Type 2 diabetic subjects and this is associated with increased hepatic lipase activity. | 11395034 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The potential role of haemostatic risk markers is largely unexplored in South Asians, who have increased morbidity and mortality from cardiovascular disease and an increased prevalence of insulin resistance. | 11395044 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that elevated PAI-1 and fibrinogen in Asians of both genders may contribute to the increased vascular risk experienced in this population; however, the role of dyslipidaemia and Factor VII are not clear in these processes. | 11395044 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These results suggest that obesity and abdominal AT accumulation are the critical correlates of elevated plasma CRP levels found in men with atherogenic dyslipidemia of the insulin resistance syndrome. | 11397704 |
| Weight Gain, Obesity, Visceral | Deregulated Nutrient Sensing | Increasing leptin fails to prevent weight gain and the hypogonadal-obesity cycle ensues causing further visceral obesity and insulin resistance. | 11399122 |
| Dyslipidemias | Deregulated Nutrient Sensing | The progressive insulin resistance leads to a high triglyceride-low HDL pattern of dyslipidemia and increased cardiovascular risk. | 11399122 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with IFG had a non-trivial undiagnosed diabetes mellitus rate (30% in men and 42% in women) and a high rate of glucose intolerance and undiagnosed DM combined (75% in men and 86% in women). | 11403519 |
| IFNG wt Allele, Glucose Intolerance (disease), Demographics Domain | Deregulated Nutrient Sensing | Women with IFG had a 1.6 fold higher risk (p = 0.04) for undiagnosed DM and a 2.1 fold higher risk (p = 0.01) for glucose intolerance and DM when compared to men. | 11403519 |
| Albuminuria | Deregulated Nutrient Sensing | Insulin resistance precedes the appearance of albuminuria in non-diabetic subjects: 6 years follow up study. | 11403858 |
| Hypertension, CTCAE, Albuminuria | Deregulated Nutrient Sensing | Insulin resistance appeared earlier than the appearance of hypertension and albuminuria. | 11403858 |
| Albuminuria | Deregulated Nutrient Sensing | Therefore, the appearance of insulin resistance should be regarded as a remarkable mediator of albuminuria. | 11403858 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology, Tumor necrosis | Deregulated Nutrient Sensing | Temporary reversal by topotecan of marked insulin resistance in a patient with myelodysplastic syndrome: case report and possible mechanism for tumor necrosis factor alpha (TNF-alpha)-induced insulin resistance. | 11404500 |
| Tumor necrosis, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor. | 11404500 |
| Myelodysplasia, Respiratory Distress Syndrome, Newborn | Deregulated Nutrient Sensing | We report here a remarkable degree of insulin resistance in a patient with adult respiratory distress syndrome and myelodysplasia. | 11404500 |
| Dyslipidemias, Biliary calculi, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, gallstones and dyslipidaemia are widespread, metabolically related, disorders that can affect the liver, often in a clinically silent fashion. | 11407669 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | In conclusion, troglitazone can restore coronary circulation by improving insulin resistance in patients with NIDDM. | 11407727 |
| Fetal Growth Retardation | Deregulated Nutrient Sensing | Insulin resistance and insulin-like growth factors in children with intrauterine growth retardation. | 11408754 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | As expected, body weight and fat distribution were associated with diabetes, hypertension, dyslipidemia and with a worsening of lipid profile. | 11410818 |
| Blood Glucose | Deregulated Nutrient Sensing | A moderately high but still normal glycemia might be a preclinical sign of insulin resistance or other disturbance of glucoregulation. | 11415852 |
| Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance precedes weight loss in adults without diabetes : the Rancho Bernardo Study. | 11415955 |
| Weight decreased, Overweight | Deregulated Nutrient Sensing | Insulin resistance is closely associated with both aging and overweight; yet in old age, weight loss is common, although insulin resistance increases. | 11415955 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | The improvement of insulin resistance in patients with adrenal incidentaloma by surgical resection. | 11422115 |
| Adrenal Cortical Adenoma | Deregulated Nutrient Sensing | All 12 patients with adrenocortical adenoma exhibited insulin resistance based on the SSPG (6.9-13.2 mmol/l). | 11422115 |
| Cushing Syndrome, Adrenal Cortical Adenoma, Neoplasms | Deregulated Nutrient Sensing | Before surgical removal of the tumours, the SSPG titre was relatively higher in the patients with pre-clinical Cushing's syndrome than in those with non-functioning with adrenocortical adenoma (mean value 11.65 vs. 8.99 mmol/l), whereas 2 of the 3 patients with non-adrenocortical tumours did not have insulin resistance. | 11422115 |
| Hypertension, CTCAE, Non-Functioning Adrenal Cortex Adenoma | Deregulated Nutrient Sensing | High prevalences of disturbed glucose tolerance, insulin resistance and hypertension were found among the patients with non-functioning adrenocortical tumours. | 11422115 |
| Hypertension, CTCAE, Adrenal Cortical Adenoma | Deregulated Nutrient Sensing | Adrenocortical adenoma may be one of the risk factors for insulin resistance that is believed to induce disturbed glucose tolerance and/or hypertension. | 11422115 |
| square decimeter | Deregulated Nutrient Sensing | This insulin resistance was further aggravated by the nicotine infusion in DM2 but not in Ctr (4.6 +/- 0.3 vs. 10.9 +/- 0.3 mg kg(-1) LBM min(-1); P < 0.0001). | 11422660 |
| square decimeter | Deregulated Nutrient Sensing | At this low infusion rate, nicotine aggravated the insulin resistance in DM2 but not in Ctr. | 11422660 |
| Exceptionally large baby (disorder), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Amniotic fluid insulin at 14-20 weeks' gestation: association with later maternal glucose intolerance and birth macrosomia. | 11423512 |
| Premature coronary artery atherosclerosis | Deregulated Nutrient Sensing | Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease. | 11427204 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | [Successful symptomatic tazarotene treatment of juvenile acanthosis nigricans of the familial obesity-associated type in insulin resistance]. | 11428078 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is an important factor in causation of macrovascular disease in type 2 diabetics. | 11428472 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The role of simvastatin in the management of dyslipidemia in patients with type 2 diabetes mellitus is not very well elucidated, particularly in the context of the recent American Diabetes Association criteria 2001. | 11428472 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease | Deregulated Nutrient Sensing | The American Diabetes Association suggests that aggressive therapy of diabetic dyslipidemia will reduce the risk of coronary heart disease in diabetics and that optimal levels are serum low-density lipoprotein cholesterol <2.60 mmol/L (< 100 mg/dl), high-density lipoprotein cholesterol >1.1 5 mmol/L (>45 mg/dl) and triglycerides <2.30 mmol/L, (<200 mg/dl). | 11428472 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | This study was planned to compare the effect of simvastatin together with behavioral modification and behavioral modification alone, in age, sex and body mass index matched patients with type 2 diabetes mellitus with dyslipidemia, in reaching the target levels of various lipids as suggested by the American Diabetes Association criteria 2001. | 11428472 |
| Low-Density Lipoproteins | Deregulated Nutrient Sensing | It was observed that low-density lipoprotein dyslipidemia was most prevalent. | 11428472 |
| Dyslipidemias | Deregulated Nutrient Sensing | In our study, behavioral modification alone did not achieve the target levels of various lipids in diabetic dyslipidemia as per the American Diabetes Association guidelines. | 11428472 |
| Calcification of coronary artery, Dyslipidemias | Deregulated Nutrient Sensing | Significant association between the progression of coronary artery calcification and dyslipidemia in patients on chronic hemodialysis. | 11431183 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | [Effects of metformin on insulin resistance and on ovarian steroidogenesis in women with polycystic ovary syndrome]. | 11431640 |
| Weight decreased, Blood Pressure | Deregulated Nutrient Sensing | Probably, weight loss improves insulin resistance and decrease in the plasma insulin level causes a reduction in blood pressure and urinary albumin excretion rate. | 11431901 |
| Heart Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The part of the cardiovascular risk factors was about 36% for smoking, 13% for diabetes mellitus, 60% for dyslipidemia and 40% for heart disease. | 11435677 |
| Obesity, Coronary heart disease | Deregulated Nutrient Sensing | C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites. | 11447077 |
| Choline Dehydrogenase, Mitochondrial, metabolic disturbance, Obesity | Deregulated Nutrient Sensing | CRP values were strongly associated with conventional CHD risk factors, measures of obesity, and metabolic disturbances associated with insulin resistance in both racial groups. | 11447077 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | CRP was associated with many other cardiovascular risk factors, particularly markers of obesity and insulin resistance, markers of inflammation and acute phase reaction, and hormone replacement therapy. | 11448405 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The risk of post-transplant diabetes increased parallel to pre-transplant degree of glucose intolerance, but was considerable even in normal glucose tolerance. | 11448794 |
| Fetal malnutrition without mention of light-for-dates | Deregulated Nutrient Sensing | "The fetal programming hypothesis" suggests that the association is caused by intrauterine malnutrition while a new hypothesis "the fetal insulin hypothesis" proposes that genetically determined insulin resistance also contributes significantly to the association. | 11449017 |
| Atherosclerosis, Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance is associated with accelerated atherosclerosis, especially coronary heart disease. | 11453033 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Corneal Endothelial Cell Loss | Deregulated Nutrient Sensing | These results indicate that endothelial dysfunction may be associated with the pathogenesis of insulin resistance syndrome as well as insulin resistance, and that the plasma TM might reflect endothelial damage better than the plasma vWF in the state of insulin resistance in patients with type 2 diabetes. | 11453033 |
| Tumor necrosis | Deregulated Nutrient Sensing | Tumor necrosis factor-alpha (TNF-alpha) may play an important role in insulin resistance. | 11453240 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this study, we hypothesized that TNF-alpha produced due to periodontal inflammation synergistically affects insulin resistance as well as TNF-alpha produced from adipose tissues in insulin-resistant type 2 diabetes patients. | 11453240 |
| Atherosclerosis | Deregulated Nutrient Sensing | Recent evidence suggests that increased activity of plasma plasminogen activator inhibitor-1, an important component of the insulin resistance syndrome, plays a crucial role in the pathogenesis of atherosclerosis. | 11456143 |
| Damage, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | All in all, the therapeutic strategy will be increasingly be oriented to such additional risk factors as diabetes mellitus, dyslipidemia or already present organic damage. | 11460393 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Increased insulin resistance in salt sensitive essential hypertension. | 11464258 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Salt sensitive essential hypertensive patients are more insulin resistant than salt resistant patients when both salt sensitivity and insulin resistance are accurately measured. | 11464258 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Indirect measures of both insulin and salt sensitivity and/or the presence of modifying factors, such as obesity or glucose intolerance, may account for differences in previous studies. | 11464258 |
| Hypertensive (finding), diabetic | Deregulated Nutrient Sensing | Thus, an abundant sodium intake may improve glucose tolerance and insulin resistance, especially in diabetic, salt-sensitive, and or medicated essential hypertensive subjects. | 11465650 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition to severe hypertension, 64 per cent of the patients had other significant high-risk factors for cardiovascular disease: 44 per cent had dyslipidemia, 28 per cent had diabetes mellitus, 15 per cent were smokers. | 11471361 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance as a major determinant of increased coronary heart disease risk in postmenopausal women with Type 2 diabetes mellitus. | 11472467 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Increased insulin resistance in association with elevated PAI-1 and dyslipidaemia appears to underpin the increased risk of CHD in women with Type 2 DM. | 11472467 |
| Dyslipidemias | Deregulated Nutrient Sensing | Probands and first degree relatives showed dyslipidemia, increased plasma insulin and glucose concentrations, higher waist--hip ratio (WHR), and blood pressure, than spouses. | 11472750 |
| Increased insulin level, Metabolic Syndrome X | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are considered key components in the metabolic cardiovascular syndrome and as independent risk factors for CVD. | 11472752 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X | Deregulated Nutrient Sensing | NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance. | 11473047 |
| No metabolic abnormalities, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance, associated metabolic abnormalities, and elevated homocysteine levels are risk factors for cardiovascular disease (CVD). | 11473077 |
| Increased insulin level, Hyperhomocysteinemia | Deregulated Nutrient Sensing | Hyperhomocysteinemia and abnormal urinary albumin excretion are both associated with hyperinsulinemia and may partially account for increased risk of CVD associated with insulin resistance. | 11473077 |
| Diffuse Axonal Injury, Glucose Intolerance (disease), Peripheral Neuropathy, Diabetes Mellitus | Deregulated Nutrient Sensing | Of patients with diabetes, 10% have peripheral neuropathy at the time of their diagnosis, suggesting that axonal injury may occur early in the course of glucose intolerance. | 11473085 |
| Uremia, Hypertriglyceridemia | Deregulated Nutrient Sensing | Association of hypertriglyceridemia and insulin resistance in uremic patients undergoing CAPD. | 11475344 |
| Uremia, Increased insulin level, Hyperlipidemia | Deregulated Nutrient Sensing | Insulin resistance (or its compensatory hyperinsulinemia) is commonly observed in uremic patients, but its association with hyperlipidemia in these patients has not been studied. | 11475344 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | These results indicate that insulin resistance is an important factor in the development of hypertriglyceridemia in CAPD patients. | 11475344 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high and it is among the highest previously reported worldwide. | 11483632 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The mechanism by which protease inhibitors cause diabetes is unclear; however, studies have noted insulin resistance and increased proinsulin. | 11485138 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Peripheral insulin resistance and impaired insulin action are the primary characteristics of type 2 diabetes. | 11485987 |
| Dyslipidemias | Deregulated Nutrient Sensing | We suggest that terazosin may be a reasonable choice because of the beneficial effect on the lipid profile in older symptomatic BPH patients with a higher ratio of dyslipidemia. | 11490211 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone improved insulin resistance and glycemic control, as well as Tg and HDL-C - which suggests that pioglitazone may reduce cardiovascular risk for patients with type 2 diabetes. | 11491207 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus. | 11491207 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of hypertension increased with age whereas smoking and dyslipidaemia decreased in both men and women. | 11494627 |
| Coronary heart disease | Deregulated Nutrient Sensing | Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease. | 11498464 |
| Increased insulin level, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | We conclude that cardiovascular risk factors associated with the insulin resistance syndrome (hyperinsulinemia, low high density lipoprotein cholesterol, high total and very low density lipoprotein triglycerides, and high fibrinogen) are likely to contribute indirectly to early-onset CHD. | 11498464 |
| Dyslipidemias, Obesity, Visceral | Deregulated Nutrient Sensing | Postprandial dyslipidemia in men with visceral obesity: an effect of reduced LDL receptor expression? | 11500319 |
| Dyslipidemias | Deregulated Nutrient Sensing | A delay in the conversion of chylomicrons to remnants probably contributed to postprandial dyslipidemia in viscerally obese subjects. | 11500319 |
| Dyslipidemias, Hypopituitarism | Deregulated Nutrient Sensing | The dyslipidemia associated with hypopituitarism may contribute to increased vascular mortality. | 11502830 |
| Dyslipidemias | Deregulated Nutrient Sensing | In men there was a significant decrease of non-HDL cholesterol, in women, there was a significant increase of subjects with diabetic dyslipidaemia. | 11505716 |
| Pancreatic carcinoma, Obesity | Deregulated Nutrient Sensing | By virtue of their influence on insulin resistance, obesity and physical inactivity may increase risk of pancreatic cancer. | 11509056 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Type 1 diabetes is associated with a high risk of coronary heart disease (CHD), despite the absence of dyslipidemia. | 11522707 |
| Turner Syndrome | Deregulated Nutrient Sensing | Muscle fiber composition and capillary density in Turner syndrome: evidence of increased muscle fiber size related to insulin resistance. | 11522717 |
| Turner Syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To assess muscle fiber composition and capillary density in Turner syndrome, a condition linked with insulin resistance and increased frequency of type 2 diabetes, and link these findings with insulin sensitivity and physical fitness. | 11522717 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance may play an important role in the development of hypertension in young males. | 11524829 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The main dyslipidemia associated with obesity is elevated serum triglyceride and decreased serum high-density lipoprotein cholesterol (HDL-C) levels. | 11526363 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The DM group had significantly more female patients (45.4 vs 21.1%, p < 0.0001), older age (62.5 +/- 8.2 vs 60.5 +/- 10.8 y, p < 0.007), less smoking (21.8 vs 43.2%, p < 0.0001), more dyslipidemia (56.8 vs 41.9%, p < 0.0001) and a higher incidence of hypertension (51.8 vs 42.5%, p = 0.01). | 11529371 |
| Obesity | Deregulated Nutrient Sensing | In females, the index of obesity, insulin resistance, or lipid metabolism did not differ significantly between the subjects with or without the beta(3)-AR gene variant either in the obese and non-obese group. | 11532330 |
| Obesity, Visceral, Obesity | Deregulated Nutrient Sensing | However, in males, when obesity becomes obvious, the beta(3)-AR gene variant is considered to influence the enhancement of insulin resistance, in association with visceral obesity. | 11532330 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Markers of insulin resistance and colorectal cancer mortality. | 11535544 |
| Colorectal Carcinoma, Congenital Abnormality | Deregulated Nutrient Sensing | Our analyses indicate that participants with high levels of blood glucose and a cluster of metabolic abnormalities linked to insulin resistance experienced a significant increased risk of colorectal cancer mortality compared with participants without the cluster. | 11535544 |
| Increased insulin level, No metabolic abnormalities, Colorectal Carcinoma | Deregulated Nutrient Sensing | Our findings are supportive of the hypotheses that glucose metabolism hyperinsulinemia, insulin resistance, and metabolic abnormalities associated with it may play a significant role in the etiology of colorectal cancer. | 11535544 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | These factors may contribute to the well-known relationship between insulin resistance and cardiovascular disease risk and might potentially become therapeutic targets in insulin resistant subjects. | 11549682 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | ApoE4 allele is associated with obesity independent of dyslipidemia in women but not men with a family history of diabetes. | 11553047 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Thus, Gly15Gly polymorphism of apM-1 gene might play a role in dyslipidaemia in type 2 diabetic patients. | 11571669 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | hypertension, smoking, dyslipidemia and diabetes) and is more common in patients with cardiovascular disease. | 11573052 |
| Hyperlipidemia, Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | The most common inherited dyslipidemia, familial combined hyperlipidemia (FCHL), is associated with insulin resistance. | 11574425 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | Possible pleiotropic effects of this insulin sensitivity locus on dyslipidemias in FCHL remain to be elucidated. | 11574425 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, concomitant disease, Simultaneous | Deregulated Nutrient Sensing | 56% had no concomitant disease, 36% had either diabetes, dyslipidemia or coronary heart disease, 8% had at least two concomitant diseases. | 11575213 |
| Dyslipidemias, diabetic, Blood Glucose | Deregulated Nutrient Sensing | In addition, 30% of patients with dyslipidemia reached the target LDL-C as defined by French recommendations (ANAES 1996) and 30% of the diabetic patients reached the target value for glycemia recommended by ADA (1997). | 11575213 |
| Kidney Failure, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is an independent factor affecting atherosclerotic arterial wall changes and cardiovascular events in ESRD. | 11576913 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C. Our aims were to investigate the host and viral specific factors associated with diabetes mellitus (DM) and insulin resistance in chronic hepatitis C patients. | 11580152 |
| Fibrosis Assessment, Hepatitis C | Deregulated Nutrient Sensing | We observed that insulin resistance in non-diabetic HCV-infected patients was related to grading of liver fibrosis, and occurs already at an early stage in the course of HCV infection. | 11580152 |
| Hypertension, CTCAE, Endothelial dysfunction, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cerebrovascular risk factors, including hypertension, smoking, diabetes mellitus, aging, dyslipidemia, and hyperhomocyst(e)inemia are linked to endothelial dysfunction. | 11583722 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The rising prevalence of type 2 diabetes, a condition associated with insulin resistance, is commonly attributed to changes in dietary patterns and physical activity levels in susceptible populations. | 11586491 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Low serum levels of high-density lipoprotein (HDL) cholesterol or apolipoprotein A-I and high serum levels of insulin increase the risk of coronary heart disease (CHD) and can indicate insulin resistance. | 11589836 |
| Metabolic Diseases | Deregulated Nutrient Sensing | The association of hepatic iron overload with metabolic disorders has been coined as the insulin resistance-associated hepatic iron overload syndrome (IR-HIO). | 11592595 |
| Obesity | Deregulated Nutrient Sensing | This data suggests that increased phospholipid transfer protein activity in obese subjects is a consequence of obesity itself without the contribution of insulin resistance and can be explained by increased synthesis of phospholipid transfer protein from the enlarged mass of adipose tissue. | 11596664 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Oxidative stress could contribute to diabetes and its complications by predisposing to insulin resistance. | 11596674 |
| Obesity | Deregulated Nutrient Sensing | Coronary endothelial dysfunction indicated as CFVR, body fat distribution and insulin resistance was quantitatively correlated in obesity. | 11597360 |
| Microalbuminuria, Cardiovascular Diseases, diabetic | Deregulated Nutrient Sensing | Micro-albuminuria is associated with insulin resistance and a high blood pressure and predicts an increased risk of cardiovascular disease in both diabetic and non-diabetic populations. | 11598395 |
| Microalbuminuria, Coronary heart disease | Deregulated Nutrient Sensing | The association between micro-albuminuria, insulin resistance, and coronary heart disease may be a consequence of growth retardation representing a common antecedent. | 11598395 |
| diabetic | Deregulated Nutrient Sensing | This suggests that insulin resistance is not necessarily an essential component of Korean elderly lean diabetic women. | 11641528 |
| Glucose Intolerance (disease), Acromegaly | Deregulated Nutrient Sensing | Risk factors for glucose intolerance in active acromegaly. | 11668352 |
| Glucose Intolerance (disease), Acromegaly, diabetic | Deregulated Nutrient Sensing | In the present retrospective study we determined the frequency of glucose intolerance in active untreated acromegaly, and searched for risk factors possibly supporting the emergence of the diabetic condition. | 11668352 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, the abnormal regulation of GCR mRNA is likely to play a significant role in the insulin resistance observed in obese patients with Type II diabetes. | 11672459 |
| Atherosclerosis | Deregulated Nutrient Sensing | Cross-sectional analysis of the IRAS (Insulin Resistance Atherosclerosis Study), a large (n=1559) tri-ethnic population (non-Hispanic whites, African-Americans and Mexican-Americans) across different states of glucose tolerance. | 11673759 |
| Increased insulin level, diabetic | Deregulated Nutrient Sensing | The purpose of this study was to explore the relation between insulin resistance and plasma levels of soluble adhesion molecules and to examine the effects of acute hyperinsulinemia on these molecules in type 2 diabetic individuals. | 11679465 |
| diabetic | Deregulated Nutrient Sensing | Overall adiposity, rather than insulin resistance, may be a determinant of plasma levels of ICAM-1 and E-selectin in type 2 diabetic individuals. | 11679465 |
| Osteogenesis, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance is frequently found in patients with ossification of the posterior longitudinal ligament of the spine. | 11679606 |
| Increased insulin level | Deregulated Nutrient Sensing | These results suggest that the lipid characteristics in postmenopausal women might be associated with insulin resistance and/or hyperinsulinemia, and relative hyperandrogenicity which thus induces an increase in the amount of Free T and a decrease in the SHBG within physiological ranges. | 11686310 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease | Deregulated Nutrient Sensing | Although individuals with diabetes mellitus frequently have dyslipidaemias and high blood pressure, much of the increased risk for coronary heart disease is not explained by these and other classical risk factors. | 11686665 |
| Hyperglycemia, Dyslipidemias, Diabetic Angiopathies, Hypertension, CTCAE | Deregulated Nutrient Sensing | Combined treatment of hyperglycaemia, dyslipidaemia and hypertension significantly decreases the frequency and severity of diabetic microvascular and macrovascular complications. | 11688065 |
| Hypertension, CTCAE, Albuminuria, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Hypertension was diagnosed in 54% of the diabetic patients, albuminuria in 53% and dyslipidaemia in 47%; there were 40 smokers (17%). | 11688065 |
| Increased insulin level, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Ninety percent of patients had an increased body mass index (BMI), 35% had dyslipidemia, 40% had sub-clinical diabetes (only 3% had overt diabetes), 60% had hyperinsulinemia, and more than 90% had enhanced levels of lipid peroxidation markers. | 11690701 |
| Increased insulin level, Steatohepatitis, Fatty degeneration, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Liver Cirrhosis | Deregulated Nutrient Sensing | Our data indicate that in our country, NAFLD may occur in young males with an increased BMI, with or without hyperinsulinemia, dyslipidemia and diabetes, generally associated with disorders of redox status, and that it may be differentiated from steatosis to steatohepatitis or cirrhosis only with a liver biopsy. | 11690701 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance in obesity: body-weight or energy balance? | 11691649 |
| cardiovascular problem | Deregulated Nutrient Sensing | Increased red blood cell count could be considered as a new aspect of the insulin resistance syndrome that could contribute to the increased risk of developing cardiovascular problems. | 11692171 |
| Nonalcoholic Steatohepatitis | Deregulated Nutrient Sensing | Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. | 11693332 |
| Diabetes Mellitus, Fatty Liver Disease | Deregulated Nutrient Sensing | Diabetes or insulin resistance were present in almost all in this cohort of patients with NASH. | 11693332 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Studies of glucose tolerance demonstrated unsuspected diabetes in six, and insulin resistance (the hallmark of syndrome X) in 85% of those tested. | 11693332 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | We hypothesize that NASH is a disorder of genetic etiology and is the hepatic manifestation of syndrome X, the insulin resistance syndrome. | 11693332 |
| Dyslipidemias | Deregulated Nutrient Sensing | Improvement of HAART-associated insulin resistance and dyslipidemia after replacement of protease inhibitors with abacavir. | 11698228 |
| Hypercholesterolemia, Hypertriglyceridemia | Deregulated Nutrient Sensing | In addition, a reversal of baseline insulin resistance, hypercholesterolemia and hypertriglyceridemia was observed in the majority of patients. | 11698228 |
| Dyslipidemias | Deregulated Nutrient Sensing | For comparable BMI and age, healthy AIs have physiologic markers for insulin resistance, dyslipidemia, and increased cardiovascular risk, compared with Caucasians. | 11701707 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma fatty acids, adiposity, and variance of skeletal muscle insulin resistance in type 2 diabetes mellitus. | 11701715 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Skeletal muscle insulin resistance (IR) is typically severe in type 2 diabetes mellitus (DM). | 11701715 |
| Kidney Failure, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | We conclude that fluvastatin may be used safely to correct dyslipidemia in patients with end-stage renal failure through the peri-transplant period. | 11703619 |
| Obesity | Deregulated Nutrient Sensing | The adrenergic receptor system is involved in thermogenesis and in the activation of lipid mobilization in fat cells, and polymorphisms in the beta-2 and beta-3 adrenoceptor genes (BAR2 and BAR3) have been reported to be associated with obesity and insulin resistance. | 11706779 |
| Blood Glucose | Deregulated Nutrient Sensing | Thus, the odds ratio for insulin resistance was 5.9 for a glycemia >= 110 mg/dl, 2.6% for BMI >= 25 kg/m(2) and 2.2 for triglycerides >= 150 mg/dl. | 11707218 |
| Coronary heart disease | Deregulated Nutrient Sensing | Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study. | 11707479 |
| Coronary heart disease | Deregulated Nutrient Sensing | Leg length is the component of stature related to insulin resistance and coronary heart disease risk. | 11707479 |
| Coronary heart disease | Deregulated Nutrient Sensing | The reported associations suggest that pre-adult influences are important in the aetiology of coronary heart disease and insulin resistance. | 11707479 |
| Hypercholesterolemia, Dyslipidemias, Insulin, Diabetes Mellitus | Deregulated Nutrient Sensing | Policosanol is a well defined mixture of higher aliphatic primary alcohols isolated from sugar cane wax with cholesterol-lowering effects proven for a dose range from 5-20 mg/day in patients with type II hypercholesterolemia and dyslipidemia associated with noninsulin dependent diabetes mellitus. | 11708574 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Impaired endothelial function with decreased nitric oxide production is shared by insulin resistance and essential hypertension. | 11710784 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Thus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension. | 11710784 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Of all the patients enrolled in the three trials, 38% were smokers, 25% had a history of myocardial infarction (MI) or stroke, and 52% had a history of dyslipidemia. | 11712773 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. | 11715069 |
| Tumor necrosis | Deregulated Nutrient Sensing | [The mechanism of tumor necrosis factor-alpha (TNF-alpha) induced insulin resistance by variation in promoter region of TNF-alpha gene]. | 11715473 |
| Lipolysis | Deregulated Nutrient Sensing | The difference in the degree of lipolysis led by the variant of the promoter region of TNF-alpha may be one of the mechanisms for the variation in the degree of insulin resistance in general population. | 11715473 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We hypothesize that the mechanism by which clozapine may produce glucose intolerance may require a preexisting latent defect in insulin secretion and insulin action. | 11724088 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Central adiposity, insulin resistance and hypertension are clearly interrelated but the mechanisms underlying this association have not been thoroughly elucidated. | 11725158 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased concentration of fibrinogen, dyslipidemia and impaired fibrinolysis are regarded as important risk factors for CVD. | 11728524 |
| hormone-sensitive lipase activity | Deregulated Nutrient Sensing | This study provides additional evidence for a role for HSL in the development of insulin resistance, from which carriers of the -60G allele, associated here with markers of insulin sensitivity in women, and with lower NEFA levels in men, might be protected. | 11731226 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Variation in the TC/HDL-C ratio may be associated with more substantial alterations in metabolic indices predictive of ischemic heart disease risk and related to the insulin resistance syndrome than variation in the LDL-C/HDL-C ratio. | 11732933 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | The objective of the present study was to present evidence that the LDL-C/HDL-C ratio may underestimate ischemic heart disease risk in overweight hyperinsulinemic patients with high triglyceride (TG)-low HDL-C dyslipidemia. | 11732933 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. | 11734573 |
| Increased insulin level | Deregulated Nutrient Sensing | In conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia. | 11734573 |
| Obesity | Deregulated Nutrient Sensing | The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. | 11739459 |
| Obesity | Deregulated Nutrient Sensing | In conclusion, the Q121 PC-1 variant and obesity have independent and additive effects in causing insulin resistance. | 11739459 |
| Increased insulin level, Hypertriglyceridemia, Coronary heart disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Decreased HDL-C is often associated with other coronary heart disease risk factors such as obesity, hyperinsulinemia and insulin resistance, hypertriglyceridemia and hypertension. | 11743583 |
| Dyslipidemias | Deregulated Nutrient Sensing | Although several genes have been identified for rare forms of dyslipidemia, the genes accounting for major variation in HDL-C levels have yet to be identified. | 11743583 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | The associations between hypertension, insulin resistance and glucose intolerance are poorly understood. | 11744037 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The association between hypertension and insulin resistance is unlikely to be explained by altered microvascular structure and function. | 11744037 |
| Glucose Intolerance (disease), Diabetic Glomerulosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | We report on 3 patients without overt diabetes, but with glucose intolerance, all male, aged 43-66 years, with histological features of diabetic glomerulosclerosis. | 11744813 |
| Coma (genus), Glucose Intolerance (disease), Diabetic Ketoacidosis | Deregulated Nutrient Sensing | The severity of reported cases ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma. | 11747852 |
| Increased insulin level, Hypertriglyceridemia, Hyperlipoproteinemia Type I | Deregulated Nutrient Sensing | In this family, hyperinsulinemia as a marker of insulin resistance may be a strong determinant of hypertriglyceridemia in the carrier with heterozygous LPL deficiency. | 11750290 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | It is concluded that glucose intolerance and central obesity are common in this rural Central Asian community. | 11755475 |
| Glucose Intolerance (disease), Aniridia | Deregulated Nutrient Sensing | PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. | 11756345 |
| Abnormality, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Taken together, our present observations suggest that heterozygous mutations in the PAX6 gene can induce eye anomaly and glucose intolerance in individuals harboring these mutations. | 11756345 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Atherosclerosis is associated with insulin resistance (IR) and dyslipidaemia. | 11757080 |
| No metabolic abnormalities, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to compare the leptin concentration, and its relationship with some anthropometric and biochemical parameters related to insulin resistance in 140 moderately obese type 2 diabetics (T2DM) and 160 age and weight matched non-diabetic controls in order to get a better insight into the possible role of leptin in the metabolic abnormalities of diabetes. | 11762704 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Although mean blood pressure and blood lipids were up to recently deemed adequate, a (too) high proportion of diabetic patients exhibited either hypertension and/or dyslipidaemia according to revised therapeutic goals cut-offs. | 11770224 |
| Inflammation, Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | Our study investigated whether familial hypoalphalipoproteinemia, a genetic form of dyslipidemia characterized by very low HDL levels, might be associated with increased inflammation markers such as C-reactive protein. | 11772869 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low testosterone levels in men and high testosterone levels in women predict insulin resistance and incident type 2 diabetes in older adults. | 11772901 |
| Obesity | Deregulated Nutrient Sensing | Leptin is important for the control of body weight and has been proposed to be a link between obesity and the insulin resistance syndrome. | 11775042 |
| Hyperleucinemia, Overweight | Deregulated Nutrient Sensing | Hyperleptinemia can be an important link in the development of overweight and the insulin resistance syndrome in subjects receiving antipsychotic drugs, especially atypical agents like clozapine. | 11775042 |
| Hyperlipidemia | Deregulated Nutrient Sensing | Laboratory investigation revealed a type V hyperlipidemia pattern, insulin resistance, and high alpha-tocopherol levels. | 11781404 |
| Hypertensive (finding), Insulin resistance syndrome | Deregulated Nutrient Sensing | [Study on relationship between insulin-resistance and syndrome differentiation typing in hypertensive patients]. | 11783264 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | To find the relationship between insulin-resistance and Syndrome Differentiation typing (SDT) in hypertensive patients. | 11783264 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | (1) Compared with healthy subjects, all hypertensive patients had apparent insulin resistance (P < 0.05). | 11783264 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance is one of the pathological basis for SDT in hypertension. | 11783264 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | With the purpose of determining how certain risk factors for type 2 diabetes such as family history of diabetes, obesity and dyslipidemia, affect the glucose-insulin response to a glucose challenge, 135 individuals (77 women and 58) men were studied. | 11787271 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia increased the basal and post challenge glucose insulin values only in men (p < 0.002). | 11787271 |
| Increased insulin level, Dyslipidemias, Diabetes Mellitus, Obesity, Deficit | Deregulated Nutrient Sensing | We conclude that, without alteration of the glycemic response, the presence of risk factors as obesity, dyslipidemia or family history of diabetes leads to basal hyperinsulinemia, as well as glucose stimulated hyperinsulinemia, however the coexistence of obesity and family history of diabetes, is responsible for a deficit in the insulin secretion by the pancreas. | 11787271 |
| Obesity | Deregulated Nutrient Sensing | Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity. | 11788478 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is associated with an increased risk of atherothrombotic vascular disease, but the mechanisms are poorly understood. | 11788478 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance and the persistence of obesity from childhood into adulthood. | 11788625 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance and obesity are associated in children as they are in adults. | 11788625 |
| Weight Gain | Deregulated Nutrient Sensing | However, although insulin resistance seems to oppose further weight gain in adults, opposite results have been found in children. | 11788625 |
| Obesity | Deregulated Nutrient Sensing | In boys, insulin resistance was not a significant predictor of adult obesity. | 11788625 |
| Obesity | Deregulated Nutrient Sensing | In obese girls, insulin resistance during childhood appears to oppose the risk of obesity in adulthood. | 11788625 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. | 11788685 |
| Dyslipidemias, Occlusion of artery (disorder) | Deregulated Nutrient Sensing | In patients with arterial occlusion of the lower extremities with baseline dyslipidaemia statin treatment proved protective, i.e. | 11789002 |
| Increased insulin level | Deregulated Nutrient Sensing | To study the relationship between insulin-resistance (IR), hyperinsulinemia and TCM Syndrome Differentiation-typing. | 11789282 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular disease (CVD) is associated with dyslipidemia and frequently with insulin resistance, both of which are in general no alleviated by antilipidemic drugs. | 11789299 |
| Hyperglycemia | Deregulated Nutrient Sensing | Subjects with isolated 2 h hyperglycaemia were mainly characterised by normal basal insulin secretion and by a marked insulin resistance associated with a blunted first-phase insulin secretion after the glucose load. | 11791152 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, Hereditary | Deregulated Nutrient Sensing | Type 2 diabetes mellitus is a heterogeneous inherited disorder characterized by chronic hyperglycemia resulting from pancreatic beta-cell dysfunction and insulin resistance. | 11791216 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate the protein expression of insulin receptor substrate-1 (IRS-1), protein tyrosine phosphatase with two src-homology 2 (SH-PTP(2)) in adipose tissues of type II diabetic patients, and explore molecular mechanisms of insulin resistance from adipose tissues of type II diabetic individuals. | 11798533 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The abnormal changes in expression of IRS-1 and SH-PTP(2) protein in adipose tissues of the patients with type II diabetic mellitus may be one of the mechanisms of leading to insulin resistance. | 11798533 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The abdominal subcutaneous adipose tissue of type II diabetic patients, as visceral adipose tissues, contributes to their insulin resistance. | 11798533 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | [Dyslipidemia-related risk factors for myocardial infarction and polymorphism of ApoE gene among myocardial infarction patients and their siblings]. | 11798896 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia is an important risk factor for MI, and polymorphism of ApoE may be an indirect risk factor of coronary heart disease genetically. | 11798896 |
| Dyslipidemias | Deregulated Nutrient Sensing | Lipid values obtained from portable lipid analyzers may be useful for screening, but they should not be used to make clinical decisions regarding the diagnosis and management of dyslipidemia in individual patients. | 11805009 |
| Premenopause, Overweight | Deregulated Nutrient Sensing | Homocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausal women. | 11806465 |
| Prostate Cancer Outcomes Study, Precocious pubarche, Pancreatic Polypeptide, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | In both obese and nonobese women, polycystic ovary syndrome (PCOS) is essentially a disorder of hyperinsulinemic insulin resistance, and it may be heralded by precocious pubarche (PP; appearance of pubic hair in girls aged <8 y). | 11809921 |
| Fetal Growth Retardation, Glucose Intolerance (disease), Islets of Langerhans | Deregulated Nutrient Sensing | Glucose intolerance in adults born with intrauterine growth retardation (IUGR) may involve peripheral insulin resistance and/or abnormal endocrine pancreas development during fetal life. | 11812745 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic low-grade inflammation may be involved in the pathogenesis of insulin resistance and type 2 diabetes. | 11812755 |
| Breast Carcinoma | Deregulated Nutrient Sensing | This study supports the hypothesis of moderate, direct associations between glycemic index or glycemic load and breast cancer risk and, consequently, a possible role of hyperinsulinemia/insulin resistance in breast cancer development. | 11822751 |
| Aortic Stiffness, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | In these elderly participants, aortic stiffness was positively associated with risk factors associated with the insulin resistance syndrome, increased common carotid intima-media thickness, heart rate, and decreased physical activity measured several years earlier. | 11824854 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | A significant correlation has been demonstrated in adults between WBC counts and some risk factors for coronary heart disease (CHD), including insulin resistance. | 11831107 |
| diabetic | Deregulated Nutrient Sensing | From these results, it can be concluded that short-term (7 days) low-intensity physical exercise combined with hospital diet reduces serum triglycerides, insulin resistance, and fasting glucose levels without affecting BMI in non-obese Japanese type 2 diabetic patients. | 11832998 |
| Hypertension, CTCAE, Ischemic stroke, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | To prevent ischemic stroke, strict control of diabetes, hypertension, and dyslipidemia and monitoring of CCA-IMT may be important. | 11833056 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity, diabetes, alcohol, dyslipidaemia and family history were important determinants of hypertension. | 11837752 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is universal but hypercholesterolemia per se is present in around 50% of dialysis patients. | 11840368 |
| Hypotension, diabetic | Deregulated Nutrient Sensing | Insulin resistance is associated with reduced nocturnal falls of blood pressure in normotensive, nonobese type 2 diabetic subjects. | 11848170 |
| diabetic | Deregulated Nutrient Sensing | Thus, our results suggest that insulin resistance is associated with decreased nocturnal BP fall in type 2 diabetic subjects. | 11848170 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Coronary risk and dyslipidemia in type 2 diabetic patients. | 11848328 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | A prospective study was carried out to find out the percentage of dyslipidemia in type 2 diabetics, to study the pattern of dyslipidemia, categorize the levels of LDL, HDL and triglycerides into higher, borderline and lower risk of developing coronary heart disease in type 2 diabetics and to compare the lipid profile with non-diabetics. | 11848328 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The major concern which our study highlights is the high percentage of LDL dyslipidemia majority of whom fell in higher risk of developing CHD. | 11848328 |
| Dyslipidemias | Deregulated Nutrient Sensing | These studies suggest a mechanism linking central obesity with insulin resistance and dyslipidaemia. | 11850747 |
| Acquired Immunodeficiency Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Lipid metabolism is partly regulated by both steroid hormones and cytokines and we have previously reported that dyslipidaemia in LD-positive men is correlated to an increase in cortisol : DHEA ratio (Christeff et al., AIDS 1999;13:2251). | 11851726 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Glycaemic control and obesity are the major determinants of diabetic dyslipidaemia in Hong Kong Chinese. | 11852371 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidaemia plays a major role in the increased mortality in diabetes. | 11852371 |
| Hypoglycemia, Dyslipidemias, Obesity, diabetic | Deregulated Nutrient Sensing | With multiple regression analysis (stepwise), dyslipidaemia was mainly associated with glycaemia, obesity and age in diabetic patients, and obesity, male gender and age in non-diabetic subjects. | 11852371 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We have confirmed the high prevalence and increased risk of dyslipidaemia in Chinese type 2 diabetic patients. | 11852371 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Exacerbation of the proinflammatory process may be a mechanism whereby a high intake of rapidly digested and absorbed carbohydrates increases the risk of ischemic heart disease, especially in overweight women prone to insulin resistance. | 11864854 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Increased levels of adhesion molecules are associated with inflammation, dyslipidaemia, and cardiovascular events. | 11865089 |
| palladium, Dyslipidemias, Peritonitis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Different comorbidity factors such as the presence of cardiovascular disease, age over 70 and dyslipidemia at the start of PD were analyzed as well as the incidence of peritonitis, the peritonitis-free interval, need for hospitalization, mortality rate, early mortality rate, survival curves (log rank) and the impact factor (Cox) on mortality for the different variables. | 11867950 |
| Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We did not find a significantly different percentage of diabetes, smoking, hypertension, dyslipidemia, myocardial infarction, and previous transient ischemic attack between the 2 groups of patients. | 11872889 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Although children and adolescents with type 1 DM seem not to show alterations in cardiac mass and function or early atherosclerotic changes in the first few years after diagnosis, their cardiovascular risk is increased as they present with dyslipidemia at an early stage of the disease. | 11874183 |
| Glucose Intolerance (disease), Thalassemia | Deregulated Nutrient Sensing | Acarbose is a well-tolerated agent for the management of thalassemic patients with glucose intolerance and normal or increased insulin secretion. | 11874186 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Secondary dyslipidaemia in pHPT has attracted little attention, although morbidity and mortality associated with cardiovascular diseases have been reported to be increased in these patients. | 11874418 |
| Dyslipidemias | Deregulated Nutrient Sensing | Proatherosclerotic dyslipidaemia characterizes mild pHPT and is effectively reversed by parathyroidectomy. | 11874418 |
| Cessation of life, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | As dyslipidaemia might contribute to the increased risk of cardiovascular diseases and death observed in pHPT, the findings favour operative intervention rather than conservative surveillance in mild, asymptomatic pHPT in postmenopausal females. | 11874418 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Obstructive sleep apnea is independently associated with insulin resistance. | 11874812 |
| Atherosclerosis, Osage language | Deregulated Nutrient Sensing | Insulin resistance is a known risk factor for atherosclerosis, and we postulate that OSA represents a stress that promotes insulin resistance, hence atherogenesis. | 11874812 |
| Sleep Disorders, Osage language | Deregulated Nutrient Sensing | Our findings suggest that OSA is independently associated with insulin resistance, and its role in the atherogenic potential of sleep disordered breathing is worthy of further exploration. | 11874812 |
| Overweight | Deregulated Nutrient Sensing | Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. | 11874813 |
| Obesity | Deregulated Nutrient Sensing | Multivariable linear regression analyses revealed that increasing AHI was associated with worsening insulin resistance independent of obesity. | 11874813 |
| Sleep-Disordered Breathing, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Thus, sleep-disordered breathing is a prevalent condition in mildly obese men and is independently associated with glucose intolerance and insulin resistance. | 11874813 |
| Increased insulin level, Dyslipidemias, Gall Bladder Diseases, Obesity | Deregulated Nutrient Sensing | Hyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease. | 11880221 |
| Increased insulin level, Dyslipidemias, Gall Bladder Diseases, Obesity | Deregulated Nutrient Sensing | In men, hyperinsulinemia and dyslipidemia may have some role in the etiology of gallbladder disease beyond their association with obesity, whereas in women, increased body size, central adiposity, and hormone replacement therapy may be more important determinants of gallbladder disease. | 11880221 |
| Tumor necrosis | Deregulated Nutrient Sensing | Tumor necrosis factor-alpha (TNF-alpha) is increasingly recognized as a key component in the development of insulin resistance and increased blood pressure. | 11882518 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hepatic insulin resistance in obese non-diabetic subjects and in type 2 diabetic patients. | 11886934 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our data indicate that both obese non-diabetic and obese type 2 diabetic patients have a blunted suppressive action of insulin on glucose production, indicating hepatic and renal insulin resistance. | 11886934 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Our research suggests that ApaI polymorphism may be associated with glucose intolerance independent of defective insulin secretion and BsmI polymorphism with insulin resistance in a nondiabetic Caucasian population. | 11887173 |
| Cushing Syndrome | Deregulated Nutrient Sensing | The slight hypercortisolism observed in some such patients may significantly contribute to this state of insulin resistance. | 11889151 |
| Chronic heart failure | Deregulated Nutrient Sensing | Differentiation of the metabolic and vascular effects of insulin in insulin resistance in patients with chronic heart failure. | 11897212 |
| Chronic heart failure | Deregulated Nutrient Sensing | Chronic heart failure (HF) is associated with insulin resistance. | 11897212 |
| Dyslipidemias, Diabetes Mellitus, Cardiac complication, Obesity, Overweight | Deregulated Nutrient Sensing | Patients aged 55 and older with newly diagnosed isolated systolic AH had the following most common factors of risk of cardiovascular complications: overweight, obesity, smoking, dyslipidemia, diabetes mellitus. | 11899825 |
| Dyslipidemias, Overweight, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In treated patients these risk factors are: overweight, obesity, dyslipidemia, diabetes mellitus, smoking. | 11899825 |
| Central visual impairment, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | In IHD without CVI dyslipidemia in most cases was associated with one of the additional risk factors (hypertension, smoking, diabetes mellitus) while in CVI it combined with two or three additional risk factors. | 11899828 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin or insulin resistance is considered a coronary heart disease (CHD) risk factor, but proinsulin may have a stronger association with CHD than insulin. | 11901041 |
| Hyperinsulinism, Dyslipidemias | Deregulated Nutrient Sensing | Smoking was also associated with hyperinsulinaemia, dyslipidaemia and high blood pressure, i.e. | 11902817 |
| Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | The acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis. | 11908557 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | This may relate to insulin resistance and dyslipidemia, which were both reported to correlate with the acute phase response in RA. | 11908557 |
| Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | We investigated whether insulin resistance and dyslipidemia could be explained by the acute phase response as well as excess weight in inflammatory arthritis. | 11908557 |
| Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Insulin resistance and dyslipidemia were highly prevalent in patients with inflammatory arthritis. | 11908557 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Initiation and/or promotion of endometrial cancer is known to be associated with estrogen and androgen (androstenedione) excess as well as with hyperinsulinemia/insulin resistance. | 11911969 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and Type II diabetes share common associations with retarded fetal growth and accelerated growth during childhood. | 11914739 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | They are dissimilar, however, in that insulin resistance is associated with thinness in childhood and low maternal BMI, while Type II diabetes is associated with high BMI in childhood and high maternal BMI. | 11914739 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In individuals with type 2 diabetes, these regular variations are altered, which has been implicated in the development of insulin resistance and hyperglycemia. | 11916916 |
| Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin resistance, particularly when body fat has a central distribution. | 11916919 |
| Cardiovascular morbidity, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Individuals with chronic renal disease are at high risk of cardiovascular morbidity and mortality, and therefore the management of dyslipidemia is particularly important in this patient population. | 11918754 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The relationship between parity and risk of diabetes is controversial, and little information is available regarding associations between parity and measures of insulin resistance and beta-cell function. | 11919126 |
| Diabetic Retinopathy, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Pro12Ala polymorphism of PPAR(gamma2) gene is not associated with diabetic retinopathy but is associated with dyslipidemia in male type 2 diabetic patients. | 11928067 |
| Increased insulin level, Carcinogenesis, Dyslipidemias, Complications of Diabetes Mellitus, Diabetes Mellitus, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Especially hyperinsulinemia as an independent secondary risk factor for hypertension, dyslipidemia--in consequences late diabetic complications and perhaps carcinogenesis may play an important role as a predictor of diabetes type 2 and biochemical marker of effectiveness of non-pharmacological and pharmacological approach in the global concept of diabetes type 2 treatment (Z. Szybinski). | 11928582 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Of them diabetes was confirmed in 11 patients, impaired glucose tolerance was observed in 9, and glucose intolerance was excluded in 22 subjects. | 11928585 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Depending on a contribution of the primary risk factors of type 2 Diabetes Mellitus (2-DM) mainly genetic factors and obesity--an independent cause of insulin receptor resistance--glucose intolerance and 2-DM may overlap the Syndrome X. | 11928588 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In the persons with glucose intolerance and new-diagnosed 2-DM insulinemia increased 2-3 fold depending on BMI, and gender. | 11928588 |
| Increased insulin level, Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Obesity and insulinemia in 2 h-OGTT in multiple analysis have been identified as a strong predictors and risk factors of impaired glucose intolerance (IGT) 2-DM fasting insulinemia may be useful as an indicator of the peripheric insulin receptor resistance. | 11928588 |
| TG gene, Microunit per Milliliter | Deregulated Nutrient Sensing | Despite a significant fall in fasting insulin levels (9.9 to 8.3 mU/l, range 8.85-19.8 to 6.33-11.6, P < 0.001) and insulin resistance (2.7 to 1.9, range 1.2-10.4 to 1-6.2, P < 0.001), mean serum TG and HDL levels were unaffected by IGF-I normalization. | 11940041 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The study included 45 patients with type 2 diabetes mellitus and dyslipidemia; 31 of these patients received a TZD (troglitazone), and 14 patients received metformin. | 11942773 |
| Hyperleucinemia | Deregulated Nutrient Sensing | Overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. | 11943833 |
| Hyperleucinemia, Overweight | Deregulated Nutrient Sensing | To evaluate the influence of overweight, waist circumference, age, gender, and insulin resistance as risk factors for hyperleptinemia. | 11943833 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Light-to-moderate alcohol consumption is associated with a lower prevalence of type 2 diabetes, reduced insulin resistance, and more favorable vascular risk profile in the severely obese. | 11943832 |
| Acute Cerebrovascular Accidents | Deregulated Nutrient Sensing | [Relation between insulin-like growth factor-1 and insulin resistance in patients with acute stroke]. | 11953210 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Fasting plasma glucose concentration was an inadequate parameter in diagnosing diabetes and intermediate categories of glucose intolerance in our cohort of subjects. | 11957556 |
| Obesity | Deregulated Nutrient Sensing | Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. | 11966382 |
| Hyperinsulinism, Polycystic Ovary Syndrome, Obesity | Deregulated Nutrient Sensing | Hyperinsulinaemia and insulin resistance are usually associated phenomena of obesity and the polycystic ovary syndrome (PCO syndrome). | 11968579 |
| diabetic | Deregulated Nutrient Sensing | In conclusion, serum thioredoxin levels may reflect the status of insulin resistance in Type 2 diabetic patients. | 11972307 |
| Hyperproinsulinemia, Blood Glucose, Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperproinsulinemia and proinsulin-to-insulin ratios in Swedish middle-aged men: association with glycemia and insulin resistance but not with family history of diabetes. | 11978587 |
| Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | These findings indicate that elevated proinsulin and proinsulin/insulin ratios are secondary to increased demands on beta-cell secretion induced by hyperglycemia and insulin resistance with no discernible influence of family history of diabetes. | 11978587 |
| Peripheral Vascular Diseases, Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Hyperglycemia, as well as smoking, dyslipidemia, and blood pressure are potentially modifiable risk factors for the development of PVD. | 11978687 |
| diabetic | Deregulated Nutrient Sensing | Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients. | 11979383 |
| diabetic | Deregulated Nutrient Sensing | From these results, it can be suggested that (1) both subcutaneous and visceral abdominal fat areas are independently associated with insulin resistance and (2) visceral fat area, but not the subcutaneous one, is associated with serum triglyceride levels in our nonobese Japanese type 2 diabetic patients. | 11979383 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | We conclude that in lean, postmenopausal hypertensive women insulin resistance is increased compared with age- and weight-matched normotensive women. | 11986914 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Thus, insulin resistance may possibly be involved as a pathogenetic factor in lean, postmenopausal hypertensive women. | 11986914 |
| Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Dyslipidemia and cardiovascular risk in type 2 diabetes mellitus patients with associated diabetic nephropathy]. | 11987671 |
| Proteinuria, Microalbuminuria, Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Cardiac complication | Deregulated Nutrient Sensing | Diabetes patients with concomitant diabetic nephropathy are especially destined to cardiovascular complications due to the presence of microalbuminuria or proteinuria, that are potent inductors of dyslipidaemia. | 11987671 |
| Diabetic Nephropathy, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Since dyslipidaemia is closely related to the progression of cardiovascular disease and mortality, an aggressive lipid-lowering therapy is recommended, irrespectively of its potential effect on diabetic nephropathy. | 11987671 |
| Lipodystrophy, Complication Aspects | Deregulated Nutrient Sensing | Our results indicate that serum adiponectin and leptin levels are extremely low in patients with generalized lipodystrophies and may be related to severe insulin resistance and its metabolic complications in lipodystrophies. | 11994394 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The role of diminished beta cell reserve and insulin resistance in secondary sulfonylurea failure of type 2 diabetes mellitus. | 11999824 |
| Failure, diabetic | Deregulated Nutrient Sensing | The objectives of this study were to determine beta cell secretory reserve and insulin resistance of secondary SU failure type 2 diabetic patients who had fairly good glycemic control compared with those who were SU responsive and the disparity of beta cell responses to glucose and non-glucose stimuli were examined in these two groups. | 11999824 |
| Thrombosis, Hypertension, CTCAE, Retinal Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Magnesium deficiency is common in type 2 diabetes and may have a negative impact on glucose homeostasis and insulin resistance, as well as on the evolution of complications such as retinopathy, thrombosis and hypertension. | 12001011 |
| Obesity | Deregulated Nutrient Sensing | To determine whether racial differences in insulin resistance between African American (AA) and white women exist in postmenopausal women and whether they are related to physical fitness and/or obesity. | 12006632 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | KK-Ay mice with insulin resistance and high urine mAlb level might be useful as models for the early stage of diabetic nephropathy. | 12012732 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Reference value and cut-off value for diagnosis of insulin resistance in type 2 diabetes mellitus]. | 12014020 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These values should be available for the diagnosis of insulin resistance in type 2 diabetes mellitus. | 12014020 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | We studied 20 non-diabetic hypertensive patients with mixed dyslipidaemia in whom serum metabolic parameters, including uric acid levels in serum and urine, were measured before and after eight weeks of indapamide administration (2.5 mg once daily). | 12017210 |
| deficiency aspects, Diabetes Mellitus, Insulin-Dependent, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Autoimmune reaction | Deregulated Nutrient Sensing | Whereas the pathogenesis of type 1 diabetes results from the autoimmune destruction of beta cells, leading to insulin deficiency, in type 2 diabetes insulin resistance as well as impaired insulin secretion are present; mechanisms that interact closely in the development of glucose intolerance. | 12017759 |
| Dyslipidemias, Hypertension, CTCAE, vinyltriethoxysilane | Deregulated Nutrient Sensing | Cigarette smoking, hypertension, dyslipidemia, physical inactivity, and alcohol consumption were not associated with risk of VTE. | 12020191 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors include smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. | 12022485 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Higher ALT concentrations were cross-sectionally associated with obesity and whole-body and hepatic insulin resistance and prospectively associated with a decline in hepatic insulin sensitivity and the development of type 2 diabetes. | 12031978 |
| Short stature | Deregulated Nutrient Sensing | Shortness at birth is associated with insulin resistance in pre-pubertal Jamaican children. | 12032649 |
| Short stature | Deregulated Nutrient Sensing | Shortness at birth is related to insulin resistance. | 12032649 |
| diabetic | Deregulated Nutrient Sensing | The diabetic patient showed insulin resistance, low AIR(Glucose), and low Sg. | 12037739 |
| Chronic progressive external ophthalmoplegia, Diabetes Mellitus | Deregulated Nutrient Sensing | Overt diabetes in CPEO seems to be a combination of insulin resistance, an insulin secretion defect, and impaired glucose effectiveness. | 12037739 |
| Microalbuminuria | Deregulated Nutrient Sensing | Association of the insulin resistance syndrome and microalbuminuria among nondiabetic native Americans. | 12039992 |
| Microalbuminuria | Deregulated Nutrient Sensing | This study investigated the association between microalbuminuria and the insulin resistance syndrome (IRS) among nondiabetic Native Americans. | 12039992 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Cardiovascular renal disease, Obesity | Deregulated Nutrient Sensing | Health promotion efforts should focus on lowering the prevalence of hypertension, as well as glucose intolerance and obesity, in this population at high risk for renal and cardiovascular disease. | 12039992 |
| Atherosclerosis, Peripheral arterial occlusive disease, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Many risk factors (age, hypertension, diabetes, tobacco use, dyslipidemia, etc) have been associated with atherosclerosis and the development of peripheral arterial occlusive disease. | 12042719 |
| Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of gemfibrozil on insulin resistance to fat metabolism in subjects with type 2 diabetes and hypertriglyceridaemia. | 12047397 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | Hypoalphalipoproteinemia (HALP) is a dyslipidemia characterized by low HDL-cholesterol (HDL-C) levels with important genetic contribution. | 12048121 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms via which pioglitazone improves insulin resistance in patients with type 2 diabetes mellitus. | 12050251 |
| Dyslipidemias, Intermediate density lipoprotein cholesterol measurement (procedure), atherosclerotic | Deregulated Nutrient Sensing | We conclude that increasing the dose of atorvastatin leads to dose-dependent, preferential and progressive reduction in particle numbers of atherogenic VLDL-2, IDL and dense LDL, and concomitantly, to enhanced cellular cholesterol efflux in type IIB dyslipidemia, thereby diminishing the atherosclerotic burden in subjects characterised by high cardiovascular risk. | 12052475 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | To evaluate the effect of N-acetyl-cysteine (NAC) on insulin secretion and peripheral insulin resistance in subjects with polycystic ovary syndrome (PCOS). | 12057717 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Our data suggest that glucose intolerance should precede lipid intolerance. | 12059096 |
| Cessation of life, Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death. | 12060058 |
| Cessation of life, Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | To compare the incidence of myocardial infarction and death in non-diabetic subjects with and without insulin resistance. | 12060058 |
| Cessation of life, Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Insulin resistance, as assessed by the HOMA method, was in this cohort of middle-aged non-diabetic subjects associated with an increased incidence of myocardial infarction and death. | 12060058 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Considering the conditions of principal interest-glucose intolerance, hypertension and obesity-one-half of all subjects demonstrated one or more of these conditions. | 12060063 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Central obesity was the most common condition, followed by hypertension and then glucose intolerance. | 12060063 |
| Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus results from an inadequate adaptation of the functional pancreatic beta cell mass in the face of insulin resistance. | 12060768 |
| Hyperlipidemia, Lipoatrophy | Deregulated Nutrient Sensing | We performed an observational study in which efavirenz was substituted for a PI for 41 patients receiving HAART who had prolonged virus suppression, clinical signs of severe lipoatrophy, hyperlipidemia, and insulin resistance. | 12060877 |
| Hyperlipidemia, Lipoatrophy | Deregulated Nutrient Sensing | We conclude that, for PI-treated patients who present with lipoatrophy, hyperlipidemia, and insulin resistance, substituting efavirenz for PIs can maintain virus suppression and immunologic response to HAART, but it does not improve the lipid profile or resolve insulin resistance or lipoatrophy. | 12060877 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increased plasma atrial natriuretic peptide (ANP) levels and impaired ANP action have been reported in patients with diabetes or insulin resistance. | 12063641 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is present in patients with Type 2 diabetes mellitus as well as in obese patients without diabetes. | 12071295 |
| Hypertensive (finding), Hypertriglyceridemia | Deregulated Nutrient Sensing | Exacerbation of insulin resistance and postprandial triglyceride response in newly diagnosed hypertensive patients with hypertriglyceridaemia. | 12080433 |
| TG gene, Hypertensive (finding), Hypertriglyceridemia | Deregulated Nutrient Sensing | The purpose of the study is to examine the differences in insulin resistance and postprandial triglyceride (TG) response between hypertensive patients with or without hypertriglyceridaemia. | 12080433 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | The results provide a rationale for the alleviation of insulin resistance and hypertriglyceridaemia in these atherosclerosis-prone hypertensive patients. | 12080433 |
| Inflammation, Hyperinsulinism, Dyslipidemias | Deregulated Nutrient Sensing | Men were centrally more obese and had increased markers of endothelial activation, inflammation and the anti-fibrinolytic state as well as hyperinsulinaemia and dyslipidaemia, compared with women. | 12080455 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The association between insulin resistance (IR) and obesity and its causal relationship with type 2 diabetes is well recognized. | 12082884 |
| Steatohepatitis, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Correlations with weight parameters and pre-existing co-morbidities including diabetes, hypertension, dyslipidemia and hepatic steatosis were made. | 12082884 |
| diabetic | Deregulated Nutrient Sensing | In all four ethnic groups (African-American, n = 55; Asian-American, n = 66; Caucasian, n = 217; Hispanic-American, n = 193), IFG/IGT and diabetic subjects exhibited progressively increasing insulin resistance and decreasing beta-cell function. | 12086947 |
| Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Both insulin resistance and impaired beta-cell function are associated with impaired glucose metabolism in all ethnic groups, with beta-cell function seeming to be more important in determining glucose disposal. | 12086947 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. | 12086969 |
| Hyperglycemia, No metabolic abnormalities, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Thus, the results of the present study emphasizes the importance of other underlying metabolic abnormalities, such as abdominal obesity and related atherogenic dyslipidemia, in the modulation of the CAD risk associated with hyperglycemia. | 12088772 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. | 12089386 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is closely associated with atherosclerosis and cardiovascular mortality in the general population. | 12089386 |
| Kidney Failure, Chronic, Atherosclerosis | Deregulated Nutrient Sensing | Patients with end-stage renal disease (ESRD) are known to have insulin resistance, advanced atherosclerosis, and a high cardiovascular mortality rate. | 12089386 |
| Kidney Failure, Chronic, Cardiovascular system | Deregulated Nutrient Sensing | We evaluated whether insulin resistance is a predictor of cardiovascular death in a cohort of ESRD. | 12089386 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | These results indicate that insulin resistance is an independent predictor of cardiovascular mortality in ESRD. | 12089386 |
| Dyslipidemias, Overweight, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | diabetes without overweight, dyslipidaemia and hypertension) is a condition of insulin resistance. | 12099955 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Overweight, central fat distribution, dyslipidaemia, hypertension and poor glycometabolic control are strong independent predictors of insulin resistance in Type 2 diabetes. | 12099955 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Subjects, who had dyslipidemia or obesity, were instructed to walk (consecutive 60 minutes, one times daily) and to consume no more than 20% total fat and 300 mg/d of cholesterol for four weeks. | 12101821 |
| Hyperleucinemia, Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Insulin resistance, hyperleptinemia, and obstructive sleep apnea in Launois-Bensaude syndrome. | 12105284 |
| Hyperleucinemia, Sleep Apnea, Obstructive, Obesity, Osage language | Deregulated Nutrient Sensing | Obesity is known to be closely associated with insulin resistance, hyperleptinemia, and obstructive sleep apnea (OSA). | 12105284 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Family and personal history of diabetes, hypertension, coronary heart disease, dyslipidemia, obesity, and biochemical data were compared between groups. | 12105842 |
| Lipodystrophy, Steatohepatitis, LEPTIN DEFICIENCY OR DYSFUNCTION, Hypertriglyceridemia | Deregulated Nutrient Sensing | Severe lipodystrophy is associated with leptin deficiency and insulin resistance, hypertriglyceridemia, and hepatic steatosis. | 12107209 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Polymorphism in the calpain-10 gene is linked to type 2 diabetes, insulin resistance, and decreased thermogenesis. | 12107250 |
| Obesity, diabetic | Deregulated Nutrient Sensing | Hyperglycaemic siblings of Type II (non-insulin-dependent) diabetic patients have increased PAI-1, central obesity and insulin resistance compared with their paired normoglycaemic sibling. | 12107743 |
| diabetic | Deregulated Nutrient Sensing | First-degree relatives of Type II (non-insulin-dependent) diabetic patients in cross-sectional studies have increased insulin resistance, associated cardiovascular risk factors and abnormalities of fibrinolysis and coagulation. | 12107743 |
| Gammopathy, Dyslipidemias | Deregulated Nutrient Sensing | In her history, we noted right optic neuritis, monoclonal gammopathy and dyslipidemia treated by fenofibrate. | 12108181 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI. | 12109775 |
| Nephrotic Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Patients with nephrotic syndrome have impaired endothelial function probably related to dyslipidemia. | 12110017 |
| Dyslipidemias, Nephrotic Syndrome | Deregulated Nutrient Sensing | Statin therapy significantly improves dyslipidemia and brachial artery endothelial function in patients with nephrotic syndrome. | 12110017 |
| Dyslipidemias, Endothelial dysfunction, Nephrotic Syndrome, Cardiovascular Diseases | Deregulated Nutrient Sensing | The findings also suggest a role for dyslipidemia in endothelial dysfunction and the risk for cardiovascular disease in nephrotic syndrome. | 12110017 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia characterised by increased levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides was obeserved in 64%, 12% and 44% of the teenagers, respectively. | 12113288 |
| Dyslipidemias | Deregulated Nutrient Sensing | The observation that many dialysis patients receiving lipid-lowering therapy had not achieved recommended LDL-C and TC levels suggests that more efficient treatment of dyslipidaemia may be indicated in this patient population. | 12113597 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impaired insulin action is a key feature of type 2 diabetes and is also found, to a more extreme degree, in familial syndromes of insulin resistance. | 12118251 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | That mutant molecules primarily involved in either carbohydrate or lipid metabolism can combine to produce a phenotype of extreme insulin resistance provides a model of interactions among genes that may underlie common human metabolic disorders such as type 2 diabetes. | 12118251 |
| Hyperlipidemia, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hyperlipidemia and insulin resistance frequently develop after renal transplantation, contributing to cardiovascular disease. | 12118856 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Hypertriglyceridemia was considered to be due to either diabetic dyslipidemia and/or tamoxifen. | 12120888 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | The patients were characterized by a high frequency of obesity and/or glucose intolerance. | 12121348 |
| Dyslipidemias | Deregulated Nutrient Sensing | Diabetic dyslipidemia is characterized by high triglyceride levels; low high-density lipoprotein cholesterol levels; small, dense low-density lipoprotein particles; and high free fatty acid levels. | 12123399 |
| Dyslipidemias | Deregulated Nutrient Sensing | We evaluated the efficacy and safety of once-daily extended-release (ER) niacin in patients with diabetic dyslipidemia. | 12123399 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low doses of ER niacin (1000 or 1500 mg/d) are a treatment option for dyslipidemia in patients with type 2 diabetes. | 12123399 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance was assessed by an oral glucose tolerance test and defined as impaired glucose tolerance or diabetes mellitus. | 12131253 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These findings suggest that common types of physical activity such as bicycling and gardening may contribute to the prevention of glucose intolerance in elderly men | 12131253 |
| Proteinuria, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Preexisting diabetic injury in the donor may increase the risk for proteinuria, compromised renal function, and posttransplant glucose intolerance. | 12134115 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Combination therapy of exercise and angiotensin-converting enzyme inhibitor markedly improves insulin sensitivities in hypertensive patients with insulin resistance. | 12135133 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The present study investigated whether the combination of exercise (increased production of BK) and ACEI (delay in breakdown of BK) might further improve insulin sensitivity in hypertensive patients with insulin resistance (HOMA-R>1.8). | 12135133 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The combination of walking and ACEI further lowered blood concentrations of insulin and HOMA-R, which suggests that this treatment is beneficial for hypertensive patients with insulin resistance. | 12135133 |
| Fatty degeneration, Failure (biologic function) | Deregulated Nutrient Sensing | We propose that the relationship between leptin and steatosis reflects a pathogenic role of leptin in hepatic insulin resistance and/or a failure of the antisteatotic actions of leptin ("peripheral leptin resistance"). | 12143049 |
| Dyslipidemias, Ischemic stroke, atherosclerotic | Deregulated Nutrient Sensing | Protruding atherosclerotic aortic plaques and dyslipidaemia: correlation to subtypes of ischaemic stroke. | 12143784 |
| Dyslipidemias, Venous Stroke | Deregulated Nutrient Sensing | Severe plaques in the proximal aorta together with dyslipidaemia are seen more frequently in patients with atherothrombotic stroke. | 12143784 |
| diabetic | Deregulated Nutrient Sensing | The differences disappeared in the diabetic subjects, probably as a result of increased prevalence of insulin resistance in this group. | 12145220 |
| Calcification of coronary artery, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Coronary artery calcification in type 2 diabetes and insulin resistance: the framingham offspring study. | 12145227 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | We categorized glucose tolerance by type 2 diabetes therapy (diagnosed diabetes) or with an oral glucose tolerance test (OGTT) (IFG, IGT, and OGTT-detected diabetes) and insulin resistance as an elevated fasting insulin level, in subjects attending the fifth examination (1991-1995) of the Framingham Offspring Study. | 12145227 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Of 325 subjects aged 31-73 years, 51% were men, 11.2% had IFG/IGT, and 9.9% had diabetes (2.8% with diagnosed diabetes); 14.5% had insulin resistance. | 12145227 |
| Atherosclerosis | Deregulated Nutrient Sensing | In age- and sex-adjusted models, subjects with insulin resistance were more likely to have subclinical atherosclerosis than those without insulin resistance (2.1, 1.01-4.2), but further risk factor adjustment weakened this association. | 12145227 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results suggest the LMNA 1908C/T single nucleotide polymorphism (SNP) is not associated with the prevalence of type 2 diabetes, although it may be a factor predisposing to insulin resistance and dyslipidemia in some Japanese. | 12145775 |
| Dyslipidemias, Atherosclerosis, Obesity, Coronary heart disease | Deregulated Nutrient Sensing | Obesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease. | 12145779 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Elevated plasma apoC-III concentration is also a feature of dyslipidemia in obesity that contributes to the kinetic defects in apoB metabolism. | 12145779 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results show that a family history of Type 2 diabetes is an independent contributor of CRP concentrations, in addition to age, total fatness, central fat accumulation, and insulin resistance. | 12147152 |
| Glucose Intolerance (disease), Insulin insensitivity | Deregulated Nutrient Sensing | Subjects with poorer glucoregulation showed higher evoked glucose and insulin, suggestive of a mild glucose intolerance accompanied by mild insulin insensitivity. | 12148936 |
| Peripheral Vascular Diseases | Deregulated Nutrient Sensing | Compared with controls, men with peripheral vascular disease had adverse metabolic profiles (relative insulin resistance and greater total cholesterol levels). | 12149100 |
| Acromegaly | Deregulated Nutrient Sensing | No correlation was observed in acromegalic patients, although those with severe insulin resistance showed the lowest ghrelin values (161+/-20 pmol/l). | 12153739 |
| Overweight | Deregulated Nutrient Sensing | Decreases in serum uric acid by amelioration of insulin resistance in overweight hypertensive patients: effect of a low-energy diet and an insulin-sensitizing agent. | 12160192 |
| Hypertensive (finding), Hyperuricemia | Deregulated Nutrient Sensing | Hyperuricemia and hyperinsulinemia/insulin resistance are commonly seen in obese subjects and hypertensive patients. | 12160192 |
| Overweight, Hyperuricemia | Deregulated Nutrient Sensing | To clarify whether the insulin resistance plays a role in hyperuricemia, we investigated alterations in serum uric acid (UA) concentrations during treatment with a low-energy diet or an insulin-sensitizing agent in overweight hypertensive patients. | 12160192 |
| Overweight | Deregulated Nutrient Sensing | The amelioration of insulin resistance by either a low-energy diet or troglitazone decreased the serum UA level in overweight hypertensive patients. | 12160192 |
| Increased insulin level | Deregulated Nutrient Sensing | Insulin resistance or hyperinsulinemia, independent of body weight and BP, may play an important role in UA metabolism in multiple risk factor syndrome. | 12160192 |
| Dyslipidemias, Diabetes Mellitus, Congestive heart failure | Deregulated Nutrient Sensing | In summary, we demonstrated that the major cardiovascular risk factors age, diabetes, CHF, smoking, and dyslipidemia are important prognostic factors in the years after nonfatal MI. | 12160913 |
| Weight Gain, Obesity | Deregulated Nutrient Sensing | Insulin resistance is a known sequela of obesity; however, the relationship of insulin resistance to future weight gain remains unclear. | 12161515 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Pure uric acid stone formers have a much higher incidence of either diabetes or glucose intolerance. | 12164880 |
| Increased insulin level, Congestive heart failure | Deregulated Nutrient Sensing | Congestive heart failure (CHF) has previously been shown to be associated with insulin resistance and hyperinsulinemia. | 12167382 |
| cell injury | Deregulated Nutrient Sensing | Although we are only beginning to understand the molecular mechanisms that mediate life span extension, the similarities between longevity regulatory pathways in organisms ranging from yeast to mice suggest that insulin/ IGF-1 signaling pathways may also regulate cell damage and longevity in humans. | 12169020 |
| Dyslipidemias | Deregulated Nutrient Sensing | Fibric acid derivatives and HMG-CoA reductase inhibitors are effective in combination for treating patients with familial dysbetalipoproteinaemia and severe combined dyslipidaemia, but combination therapy affects compliance and increases the risk of side effects. | 12181212 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | HDL-C levels in patients with type IIa, IIb, or IV dyslipidemia were increased by a respective 10.9% (P < 0.001), 16.1% (P < 0.001), and 12.1% (P < 0.05), whereas TG levels were decreased by a respective 27.7% (P < 0.001), 46.4% (P < 0.001), and 40.2% (P < 0.05). | 12182255 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | In the study population with moderate dyslipidemia (types IIa and IIb), it promoted beneficial changes in major lipid risk factors for cardiovascular disease. | 12182255 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The p85alpha subunit of phosphatidyl inositol 3 kinase (PIK3R1) and the regulatory subunit 3 of protein phosphatase 1 (PPP1R3) were selected as candidate genes because both encode key proteins involved in insulin signalling and because polymorphisms in these genes have been previously implicated in insulin resistance or type II diabetes. | 12185156 |
| Data types - Address | Deregulated Nutrient Sensing | The results support the hypothesis for a common genetic aetiology predisposing to insulin resistance and AD. | 12185156 |
| Behavior, Cardiovascular Diseases | Deregulated Nutrient Sensing | The association between physical activity, dietary behaviors, and elevated cardiovascular disease risk factor components of the insulin resistance syndrome in adults with mental retardation was identified. | 12186577 |
| Increased insulin level, Obesity, Abdominal | Deregulated Nutrient Sensing | Those who participated in more frequent bouts of physical activity or who consumed lower dietary fat intakes were approximately one third as likely to have hyperinsulinemia and abdominal obesity compared to those who participated in less frequent physical activity or who consumed higher fat intakes, suggesting that these behaviors are protective against elevated components of the insulin resistance syndrome. | 12186577 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to investigate the associations between components of adult height (leg length, trunk length, ratio of leg to trunk length) and Type II (non-insulin-dependent) diabetes mellitus and insulin resistance. | 12189439 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results suggest that poor infant nutrition is an important causal factor in the development of Type II diabetes and insulin resistance in later life. | 12189439 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | One patient had type 2 diabetes treated by diet alone and one had a history of glucose intolerance. | 12190177 |
| Hyperproinsulinemia, Hyperleucinemia, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance syndrome that are linked to the prospective risk of cardiovascular diseases. | 12190889 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | [Potential role of leptin and insulin resistance assessed by the glucose clamp technique in coronary artery disease]. | 12194643 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Leptin may correlate with insulin resistance and be an important factor in patients with coronary artery disease. | 12194643 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Therefore, we examined whether plasma leptin levels and insulin resistance are linked with coronary artery disease. | 12194643 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Plasma leptin levels are correlated with insulin resistance and may be associated with coronary artery disease. | 12194643 |
| Lipodystrophy | Deregulated Nutrient Sensing | A CLA-induced insulin resistance has previously been described only in lipodystrophic mice. | 12196420 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of total glucose intolerance (diabetes mellitus + impaired glucose tolerance) was 18.4%. | 12197326 |
| Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease), square decimeter | Deregulated Nutrient Sensing | To know the prevalence of type 2 diabetes mellitus (DM2) and glucose intolerance (GIT) in the adult population in Asturias. | 12199991 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | These data indicate that in diabetic patients, extended-release niacin (1) is effective for separately treating diabetic dyslipidemias associated with abnormal LDL size, HDL-2, and Lp(a) independently of glycated hemoglobin levels; (2) must be used with modern and aggressive oral hypoglycemic agents or insulin treatment; and (3) is a major drug for the treatment of diabetic dyslipidemias because of its broad spectrum of effectiveness for the ALP and Lp(a). | 12200755 |
| Somatotropin deficiency | Deregulated Nutrient Sensing | Our results suggest that short-term administration of the highest GH dose induced insulin resistance, whereas the lowest dose (0.0017 mg/kg/day) could represent the optimal starting dose in GHD adults due to its beneficial effects on beta-cell function without compromising SI. | 12201825 |
| Dyslipidemias, Coronary heart disease, Diabetes Mellitus, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE | Deregulated Nutrient Sensing | The increased prevalence of coronary heart disease (CHD) in UK resident Indo-Asians is unexplained by the traditional cardiovascular risk factors of dyslipidaemia, hypertension, smoking and diabetes mellitus. | 12202835 |
| Glucagonoma, Glucose Intolerance (disease), Jaundice, Obstructive | Deregulated Nutrient Sensing | One patient (glucagonoma) presented with obstructive jaundice and mild glucose intolerance. | 12206598 |
| Cerebrovascular Disorders | Deregulated Nutrient Sensing | [Relationship between insulin resistance and clustering of risk factors of cerebrovascular disease]. | 12212210 |
| Cerebrovascular Disorders | Deregulated Nutrient Sensing | To study the relationship between insulin resistance and clustering of risk factors of cerebrovascular disease. | 12212210 |
| Cerebrovascular Disorders | Deregulated Nutrient Sensing | Insulin resistance is associated with clustering of risk factors of cerebrovascular disease, the more resistant, the more clustered. | 12212210 |
| Overweight | Deregulated Nutrient Sensing | The association between overweight, high blood pressure (BP), and insulin resistance is well established, but the role of body fat distribution in this association has yet to be fully elucidated. | 12219872 |
| Overweight | Deregulated Nutrient Sensing | The aim of this study was to investigate the role of central adiposity in the association between overweight, high BP, and insulin resistance. | 12219872 |
| Obesity, Coronary heart disease | Deregulated Nutrient Sensing | Relationship between obesity, insulin resistance, and coronary heart disease risk. | 12225719 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Obesity and insulin resistance are both powerful predictors of CHD risk, and insulin resistance at any given degree of obesity accentuates the risk of CHD and type 2 diabetes. | 12225719 |
| Obesity | Deregulated Nutrient Sensing | Male gender, central obesity, elevated fasting glucose, and insulin resistance were associated with less favorable lipid levels. | 12226139 |
| Weight decreased, Dyslipidemias | Deregulated Nutrient Sensing | To characterize dyslipidemia before and after weight loss in the severely obese. | 12226139 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidemia of obesity is related to weight distribution, insulin sensitivity, and impaired glucose tolerance. | 12226139 |
| Deficit, Diabetes Mellitus | Deregulated Nutrient Sensing | Type 2 Diabetes is characterized by a deficit in early insulin secretion and increased insulin resistance. | 12235731 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients undergoing cardiac transplantation are at increased risk of dyslipidemia (60% to 80%). | 12236939 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was also present in at least half of both types of patients. | 12240795 |
| Lipodystrophy | Deregulated Nutrient Sensing | Clinical, endocrine and metabolic studies in the kindred of familial partial lipodystrophy--a syndrome of insulin resistance. | 12240840 |
| LMNA wt Allele | Deregulated Nutrient Sensing | The majority (2/3rd) of female members showed typical phenotypic features of FPLD, with a clustering of cardiovascular risk factors and insulin resistance syndrome. | 12240840 |
| LMNA wt Allele, Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | More than half the men without phenotypic features of FPLD had either IGT/DM, dyslipidemia, hypertension or cardiovascular disease. | 12240840 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Subclinical hypothyroidism was associated with a high prevalence of dyslipidemia and a high prevalence of CAD. | 12242320 |
| Biliary calculi, Cardiovascular Diseases, Dyslipidemias, Respiratory problem, Degenerative polyarthritis, Malignant Neoplasms, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity increases the risk for type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, respiratory problems, certain cancers, gallstones, osteoarthritis, and lowered life expectancy. | 12269468 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | The prevalence of DM significantly increased in subjects by increases in blood pressure, and triglyceride and the relative risk in the prevalence of DM was significantly high with dyslipidemia (Odds ratio 2.29, 95% CI: 1.16-3.49). | 12298429 |
| Diabetes Mellitus, Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), at least in the majority of patients characterized by insulin resistance and increased visceral fat, appears to be precipitated by the exposure of tissues to excessive levels of free fatty acids; this can contribute to the muscle insulin resistance, excessive hepatic gluconeogenesis, and beta cell dysfunction that collaborate to impair glycemic control. | 12323111 |
| Hyperglycemia | Deregulated Nutrient Sensing | The resultant hyperglycemia, in turn, exacerbates the insulin resistance and beta cells dysfunction. | 12323111 |
| Prediabetes syndrome, Haiti | Deregulated Nutrient Sensing | A new strategy for achieving rapid loss of body fat - hepatothermic therapy (HT), an integrated approach involving exercise training, low-fat, low-glycemic-index food choices, and a supplementation program that promotes hepatic fatty acid oxidation - shows promise for alleviating the excessive fat exposure at the root of the diabetic syndrome, as well as the underlying insulin resistance syndrome responsible for increased macrovascular risk. | 12323111 |
| Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. | 12351442 |
| Hyperglycemia, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Clustering of classical cardiovascular risk factors is insufficient to account for the excess coronary artery disease (CAD) of patients with diabetes, and chronic hyperglycemia and insulin resistance (IR) are obvious culprits. | 12351442 |
| Muscle (organ) | Deregulated Nutrient Sensing | Insulin resistance is frequently associated with increased lipid content in muscle and liver. | 12351443 |
| diabetic, Muscle (organ) | Deregulated Nutrient Sensing | In conclusion, these results indicate that IMCLs relate to insulin resistance in type 2 diabetic patients at baseline and that insulin-mediated near-normoglycemia for approximately 3 days reduces fasting glucose production but stimulates lipid accumulation in liver and muscle without affecting insulin sensitivity. | 12351443 |
| Atherosclerosis | Deregulated Nutrient Sensing | Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities study. | 12351449 |
| Atherosclerosis | Deregulated Nutrient Sensing | The extent to which groupings of insulin resistance-related cardiovascular risk factors synergize to produce atherosclerosis beyond what is expected from their additive effects is uncertain. | 12351449 |
| Dyslipidemias | Deregulated Nutrient Sensing | OxLDL increase may explain the high atherogenic potency of dyslipidemia in the prediabetic state. | 12351454 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Our results show that postmenopausal women with diabetes had increased dyslipidemia compared with nondiabetic women. | 12351460 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | The increased risk of coronary heart disease associated with type 2 diabetes may be partially explained by dyslipidemia characterized by high plasma triacylglycerol (TAG), low HDL cholesterol, and a predominance of atherogenic small dense LDLs. | 12351465 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fish oil supplementation may partially correct the dyslipidemia of type 2 diabetic patients. | 12351465 |
| diabetic | Deregulated Nutrient Sensing | However, the putative very important aspect of diabetic dyslipidemia-the predominance of small dense LDL particles-was unaffected by fish oil. | 12351465 |
| diabetic | Deregulated Nutrient Sensing | Elevated CRP in diabetic women might reflect a particular sensitivity to insulin levels or might reflect insulin resistance. | 12351483 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Syndrome X (clustering of insulin resistance, dyslipidaemia and hypertension) in adults with central obesity has been suggested to be a consequence of poor foetal development. | 12355325 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia is considered to be indicative of insulin resistance. | 12357293 |
| diabetic | Deregulated Nutrient Sensing | We aimed at elucidating the interrelations between leptin, insulin and insulin resistance in type 2 diabetic patients. | 12357293 |
| Autonomic nervous system | Deregulated Nutrient Sensing | Furthermore, heart rate recovery after exercise was related to several of the major components of the insulin resistance syndrome, thereby establishing a link between this syndrome and cardiac autonomic nervous activity. | 12360163 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common CVR factors were dyslipidemia (59.5%), smoking (19%) and diabetes (16%). | 12365077 |
| Hypertensive disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Nearly two patients out of three presented at least one other major cardiovascular risk factor in addition to HBP (cigarette smoking, diabetes mellitus or dyslipidemia): 63.9% in 1999 and 64.4% in 2000. | 12365081 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The present study implies that younger women with CAD may have a higher prevalence of dyslipidemia, diabetes and smoking. | 12368928 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To asses whether clinically severe insulin resistance and poor metabolic control in patients with type 11 diabetes are associated with aberrant expression or function of the p21ras pathway. | 12369726 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Taken together, these data indicate that clinically significant severe insulin resistance does not modify the expression, regulation and activation of p21ras pathway in PBMC of patients with type II diabetes. | 12369726 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Supplementation with t10c12 CLA markedly increased 8-iso-PGF(2alpha) (578%) and C-reactive protein (110%) compared with placebo (P<0.0001 and P<0.01, respectively) and independent of changes in hyperglycemia or dyslipidemia. | 12370214 |
| Type 2 | Deregulated Nutrient Sensing | The insulin resistance syndrome among type II diabetics. | 12370709 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Relationships of the systolic blood pressure response during exercise with insulin resistance, obesity, and endurance fitness in men with type 2 diabetes mellitus. | 12370842 |
| Demographics Domain | Deregulated Nutrient Sensing | Based on these results, insulin resistance was suggested to be independently associated with the resting DBP and SBP response to standardized exercise intensity in type 2 DM patients. | 12370842 |
| Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Peritoneally dialyzed subjects (CAPD) are prone to dyslipidemia and have a high risk of cardiovascular death. | 12371384 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Carotid hemodynamic alterations in hypertensive patients with insulin resistance. | 12372671 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance (IR) is implicated in the pathogenesis of atherosclerosis. | 12372671 |
| Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Fenofibrate is a potent hypolipemic agent, widely used in patients with renal insufficiency in whom dyslipidemia is frequent. | 12372935 |
| Increased insulin level, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia has been reported in patients with chronic renal failure. | 12372963 |
| Obesity, diabetic | Deregulated Nutrient Sensing | Impact of Prol2Ala variant in the peroxisome proliferator-activated receptor (PPAR) gamma2 on obesity and insulin resistance in Japanese Type 2 diabetic and healthy subjects. | 12375694 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | We examined the roles of the Pro12Ala variant of PPAR gamma2 in obesity and insulin resistance in 402 Japanese patients with type 2 diabetes and 116 control subjects. | 12375694 |
| diabetic | Deregulated Nutrient Sensing | These data suggest that the Pro12Ala polymorphism of PPAR gamma2 does not influence insulin resistance but body composition in Japanese diabetic subjects. | 12375694 |
| Hyperglycemia | Deregulated Nutrient Sensing | These data demonstrate that overexpression of hIGFBP-3 results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance. | 12376320 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and other cardiovascular disease risk factors. | 12376440 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Belonging to manual social classes in childhood and in adulthood was independently associated with increased insulin resistance, dyslipidaemia, and general obesity. | 12376440 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Women who were in manual social classes in childhood remained at increased risk of insulin resistance, dyslipidaemia, and obesity--even if they moved into non-manual social classes in adulthood--compared with women who were in non-manual social classes at both stages. | 12376440 |
| Obesity, Abdominal, Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Prevalence rates of overweight,obesity, central obesity and dyslipidaemia. | 12380877 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Compared to lean subjects, obese men and women had significantly higher mean serum TC, TG, LDL-C and a higher prevalence of dyslipidaemia. | 12380877 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patient characteristics were comparable on recruitment excluding family history of cardiovascular disease (P=0.003), dyslipidaemia (P=0.004) and previous history of MI (P=0.007). | 12383139 |
| Aortic arch calcification, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | In simple regression analysis the gravity of aortic arch calcification was positively correlated with age (p=0.01), diabetes mellitus (p=0.014), hypertension (p=0.022), dyslipidemia (p=0.038) and coronary artery disease (p=0.041). | 12384643 |
| Aortic arch calcification, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Gravity of aortic arch calcification in adult Greek patients may easily be assessed on routine chest X-rays and is positively correlated with coronary artery disease, as well as important cardiovascular risk factors (age, diabetes mellitus, hypertension and dyslipidemia). | 12384643 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance may be a factor in the etiology of hypertension, and habitual alcohol intake may modify this relationship. | 12393073 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Our findings suggest a close association between insulin resistance and the incidence of hypertension in Japanese. | 12393073 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is closely related to developing type 2 diabetes mellitus. | 12402978 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We investigated the interactions among visceral fat accumulation, FFA metabolism and insulin resistance in 20 patients with type 2 diabetes mellitus, including 11 obese and 9 non-obese subjects. | 12402978 |
| SR 202, Hypertrophy | Deregulated Nutrient Sensing | In vivo, decreasing PPARgamma activity, either by treatment with SR-202 or by invalidation of one allele of the PPARgamma gene, leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance. | 12403851 |
| TG gene | Deregulated Nutrient Sensing | Insulin resistance is often accompanied by elevated plasma triglycerides (TG) and a preponderance of small, dense low-density lipoprotein (LDL) particles. | 12404201 |
| TG gene | Deregulated Nutrient Sensing | However, it remains unclear whether or not insulin resistance is related to LDL particle size, independent of plasma TG. | 12404201 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Peroxisome proliferator activated receptor-gamma is an important factor in adipocyte differentiation and energy metabolism and is thus a candidate gene for obesity, insulin resistance and dyslipidaemia. | 12406034 |
| Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | These symptoms and signs include risk factors for cardiovascular disease such as hypertension, phenotype IV lipoproteinemia, insulin resistance, cardiac and vascular dysfunction, and morbidity in cardiovascular diseases. | 12412780 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Neither homeostasis model assessment nor quantitative insulin sensitivity check index can predict insulin resistance in elderly patients with poorly controlled type 2 diabetes mellitus. | 12414910 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, neither HOMA IR nor QUICKI should be used as an index of insulin resistance in elderly patients with poorly controlled type 2 diabetes mellitus. | 12414910 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperglycemia, dyslipidemia, and hypertension were evaluated as obesity-related complications. | 12419927 |
| Tumor necrosis | Deregulated Nutrient Sensing | The cytokine tumour necrosis factor-alpha (TNF-alpha) is involved in the development of obesity-linked insulin resistance. | 12421433 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our data in a large and modern day pHPT series, with a preponderance of asymptomatic patients, confirm increased insulin resistance and pre-valence of IGT and undiagnosed diabetes. | 12421435 |
| Acromegaly | Deregulated Nutrient Sensing | Growth hormone receptor antagonist improves insulin resistance in acromegaly. | 12423627 |
| Sialorrhea | Deregulated Nutrient Sensing | Growth hormone hypersecretion is a known cause of insulin resistance. | 12423627 |
| Weight decreased, Acromegaly | Deregulated Nutrient Sensing | The results show that the Pegvisomant is an effective agent for improving insulin resistance in subjects who have acromegaly and that this effect is independent of weight loss. | 12423627 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no relation between ischemic ETT and other major cardiac risk factors (hypertension, dyslipidemia, smoking, sex, duration of diabetes, BMI, and glycated hemoglobin levels). | 12424409 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes or glucose intolerance occurred in 18 GH-treated men vs 7 not receiving GH (P =.006). | 12425705 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Because adverse effects were frequent (importantly, diabetes and glucose intolerance), GH interventions in the elderly should be confined to controlled studies. | 12425705 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | Because mortality rate after MI has been previously shown to be increased in diabetic patients, screening for glucose intolerance appears to be as essential as for standard cardiovascular risk factors. | 12426825 |
| diabetic | Deregulated Nutrient Sensing | The (-)786T-C mutation of the eNOS gene is associated with insulin resistance in both Japanese non-diabetic subjects and Type II diabetic patients. | 12436344 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Apolipoprotein E kinetics: influence of insulin resistance and type 2 diabetes. | 12439646 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance related to obesity and diabetes is characterized by an increase in plasma TG-rich lipoprotein concentrations. | 12439646 |
| Obesity | Deregulated Nutrient Sensing | Whereas obesity did not influence apoE kinetic parameters in itself, insulin resistance may lead to an increase in VLDL apoE production and fractional catabolic rates. | 12439646 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone has been shown to be effective and well tolerated in the treatment of patients with type 2 diabetes, as it reduces insulin resistance and improves glycaemic control and abnormal lipid profiles. | 12439788 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with smoking habit, dyslipidemia, and diabetes mellitus were excluded from the study. | 12441213 |
| Hyperlipidemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Clinical lipoatrophy in HIV-1 patients on HAART is not associated with increased abdominal girth, hyperlipidaemia or glucose intolerance. | 12444941 |
| Hyperlipidemia, Glucose Intolerance (disease), Lipoatrophy | Deregulated Nutrient Sensing | Lipoatrophic patients on HAART with neither increase in abdominal circumference, nor hyperlipidaemia nor glucose intolerance may have side-effects to protease inhibitor treatment, to nucleoside reverse transcriptase inhibitor treatment (stavudine) or suffer from a drug-independent condition. | 12444941 |
| Dyslipidemias, Diabetes Mellitus, Sleep Apnea, CTCAE, Depression, CTCAE, Asthma, Acid reflux | Deregulated Nutrient Sensing | Major improvements have occurred in diabetes, asthma, gastroesophageal reflux, dyslipidemia, sleep apnea and depression. | 12448387 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia (high triacylglycerols and low HDL cholesterol) was more prevalent among Hispanics with than without diabetes. | 12450885 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hispanics with diabetes were at higher risk of dyslipidemia than were those without diabetes. | 12450885 |
| Insulin Secretion, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. | 12453914 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion. | 12453914 |
| Increased insulin level | Deregulated Nutrient Sensing | However, both a low prepregnancy maternal BMI and older maternal age at delivery were associated with hyperinsulinemia and evidence of insulin resistance in the offspring. | 12453959 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. | 12453959 |
| GDC Comorbidity Terminology, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Comorbid conditions of hypertension and dyslipidemia were not as well managed. | 12453965 |
| GDC Comorbidity Terminology, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The comorbid conditions of hypertension and dyslipidemia are not optimally managed according to the ADA guidelines. | 12453965 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Diabetes mellitus, impaired fasting glucose level, or insulin resistance are associated with increased risk of cardiovascular disease. | 12456232 |
| Cataract, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity increases the risk of developing cataract overall, and of PSC cataract in particular; the etiology of PSC cataract may be mediated at least in part by glucose intolerance and insulin resistance, even in the absence of clinical diabetes. | 12461675 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Hypertension, dyslipidemia and type 2 diabetes, important cardiovascular risk factors, are strongly linked to obesity. | 12464375 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The lowest values of the areas were noted in detecting women with dyslipidemia and the highest in detecting those with type 2 diabetes. | 12464375 |
| Critical Illness | Deregulated Nutrient Sensing | These data suggest that hepatic insulin resistance in prolonged critically ill patients, reflected by high serum IGFBP-1 levels, is not overcome by intensive insulin therapy, and that this may affect patient outcome. | 12466347 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Postprandial hyperlactemia | Deregulated Nutrient Sensing | Postprandial hyperlipemia and small, dense LDL particles are features of dyslipidemia in type 2 diabetes. | 12469362 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is characterized by beta cell dysfunction and insulin resistance (IR). | 12477148 |
| Impaired T cell function | Deregulated Nutrient Sensing | We found that both IFG and DM were associated with beta cell dysfunction, insulin resistance, and elevated serum triglycerides. | 12477148 |
| IFNG wt Allele, Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We conclude that the Ghanaian patients with IFG and type 2 diabetes were non-obese and exhibited severe beta cell dysfunction, insulin resistance, and elevated triglycerides, but none of the other conventional risk factors, at the time of diagnosis. | 12477148 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | However, the well established cardiovascular risk factors, such as body mass index, body fat distribution, and blood pressure did not track with the increasing glucose intolerance in the native Ghanaians. | 12477148 |
| Hypercholesterolemia, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | To determine the percentage of hypercholesterolemic patients who had met the criteria as total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), defined by the Chinese National Recommendations for Prevention and Treatment of Dyslipidemia. | 12482372 |
| Dyslipidemias | Deregulated Nutrient Sensing | Data from this study indicated that a significant gap still existed between dyslipidemia prevention principles and clinical practices, suggesting that more aggressive treatment of dyslipidemia is needed. | 12482372 |
| Atherosclerosis | Deregulated Nutrient Sensing | To illustrate the impact of westernization of lifestyle on the development of pre-clinical atherosclerosis in Japanese people, we compared risk factors for atherosclerosis such as serum lipids, blood pressure, BMI, insulin resistance, and smoking habits between non-diabetic native Japanese and non-diabetic Japanese Americans. | 12482552 |
| Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Atorvastatin and the dyslipidemia of early renal failure. | 12482566 |
| Electrocardiogram: myocardial infarction (finding), Atherosclerosis | Deregulated Nutrient Sensing | Since insulin resistance represents an important risk factor for atherosclerotic vascular disease and myocardial infarction, we investigated the involvement of the PC-1 K121Q polymorphism in the development of myocardial infarction. | 12483464 |
| Dyslipidemias | Deregulated Nutrient Sensing | LDL phenotype B is a component of diabetic dyslipidaemia, but its diagnosis is cumbersome. | 12486496 |
| Dyslipidemias, Hyperinsulinism, Illness (finding), Obesity, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | This report confirms findings in previous studies that fast-growing BPH is a risk factor for NIDDM, hypertension, tallness, obesity, dyslipidaemia and hyperinsulinaemia. | 12487736 |
| ovarian neoplasm | Deregulated Nutrient Sensing | This study supports the hypothesis of a direct association between GI and GL and ovarian cancer risk and, consequently, of a possible role of hyperinsulinemia/insulin resistance in ovarian cancer development. | 12488297 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The aims were to estimate the prevalence of glucose intolerance and 7-yr incidence of Type II (non-insulin-dependent) diabetes mellitus in this population. | 12488952 |
| diabetic | Deregulated Nutrient Sensing | C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients. | 12489071 |
| diabetic | Deregulated Nutrient Sensing | These results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients. | 12489071 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In low and moderate risk patients (n=31) with borderline hypertension, dyslipidemia and pronounced obesity mainly non-drug measures were employed directed at lowering of excess body mass. | 12494181 |
| Proteinuria, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In very high risk patients (n=79) with diabetes, excessive body mass, dyslipidemia and proteinuria complex therapy consisting of antihypertensive and hypoglycemic drugs and non-drug interventions was used. | 12494181 |
| Cerebrovascular Disorders | Deregulated Nutrient Sensing | Leptin may be an important link for the development of cerebrovascular disease in the insulin resistance syndrome in men. | 12499713 |
| Hyperlipidemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Micronized fenofibrate may be considered an effective first-line therapy for patients with primary hyperlipidemia, particularly those with type IIb mixed dyslipidemia or type 2 diabetes. | 12500022 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The Pro12Ala polymorphism in the PPARgamma2 gene has been associated with reduced risk of type 2 diabetes and insulin resistance. | 12502512 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We demonstrated an association between the Ala allele and reduced risk of diabetes and insulin resistance in twins. | 12502512 |
| Obesity | Deregulated Nutrient Sensing | To assess the independent associations of a broad range of early life risk factors and adult obesity with adult insulin resistance. | 12502664 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance is an important risk factor for type 2 diabetes and coronary heart disease. | 12502664 |
| Obesity | Deregulated Nutrient Sensing | The degree of obesity did not relate to insulin resistance but was independently correlated with inflammatory proteins, uric acid, and systolic BP, variables that were often abnormal in this population. | 12502667 |
| Obesity, Blood Glucose | Deregulated Nutrient Sensing | In these grossly obese children, both insulin resistance and impaired insulin secretion contribute to the elevation of glycemia, and the degree of obesity is related to cardiovascular risk factors independently of insulin resistance. | 12502667 |
| Dyslipidemias, Hyperlipoproteinemia Type III | Deregulated Nutrient Sensing | Patients with dysbetalipoproteinaemia diagnosed by the presence of cholesterol-enriched very-low-density lipoproteins (VLDL) and/or dyslipidaemia associated with homozygosity for apolipoprotein E2 or carriers of the apoE2 (Arg145-->Cys) mutation. | 12506591 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Patients with severe mixed hyperlipidaemia or clinical stigmata of dyslipidaemia should be assessed at a lipid clinic for a specific diagnosis and initiation of therapy. | 12506591 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Because high waist-to-hip ratio (WHR) and high serum insulin levels have been reported to be associated with an increased risk of prostate cancer, we assessed the relationship between insulin resistance and prostate cancer risk in Chinese men. | 12509402 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Relative to men in the lowest tertiles, men in the highest tertile of insulin sensitivity had a reduced risk of prostate cancer (odds ratio [OR] = 0.35, 95% confidence interval [CI] = 0.21 to 0.60), but men in the highest tertile of insulin resistance had an increased risk of prostate cancer (OR = 2.78, 95% CI = 1.63 to 4.72). | 12509402 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Because of the retrospective design of this study, the role of insulin resistance in prostate cancer needs to be confirmed in prospective studies. | 12509402 |
| square decimeter, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results suggest that in patients with DM2, the levels of fasting and absorptive FFA are significantly elevated, which is negatively correlated with the decline of ISI, implying the association of abnormal fasting and absorptive FFA and insulin resistance in patients with type 2 diabetes. | 12515147 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | However, no differences were observed between the two groups as far as blood glucose control, arterial hypertension and dyslipidaemia were concerned. | 12518120 |
| Demographics Domain | Deregulated Nutrient Sensing | In a prospective observational study, eight Type 2 DM patients with severe insulin resistance (insulin dose 1.92 +/- 0.66 U/kg per day (mean +/-sd)), in poor metabolic control (HbA(1c) 12.0 +/- 1.7%), were treated with i.v. | 12519325 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Indices of obesity, dyslipidemia, and insulin resistance in apparently healthy Caribbean subjects. | 12526016 |
| Dyslipidemias, Liver Dysfunction | Deregulated Nutrient Sensing | Liver dysfunction in HNF-1alpha-null mice includes severe hepatic glycogen accumulation and dyslipidemia. | 12529398 |
| Thrombus, Ischemic stroke | Deregulated Nutrient Sensing | Clustering of thrombotic factors with insulin resistance in South Asian patients with ischaemic stroke. | 12529744 |
| Thrombus, Cerebrovascular accident | Deregulated Nutrient Sensing | We aimed to investigate significant correlations of insulin resistance with thrombotic factors in South Asians with stroke. | 12529744 |
| Thrombus, Ischemic stroke, Vascular Diseases | Deregulated Nutrient Sensing | There is extensive clustering of metabolic and thrombotic factors with insulin resistance in South Asian patients with ischaemic stroke, which may contribute to high prevalence of vascular disease in this population. | 12529744 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Coagulation factor VII activity, Arg/Gln353 polymorphism and features of insulin resistance in first-degree-relatives of South Asian patients with stroke. | 12529745 |
| Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | Circulating levels of Factor VII:C are determined by R353Q genotype and cluster with other risk factors associated with insulin resistance in South Asian ischaemic stroke patients, first-degree relatives and control subjects but are not related to stroke or a family history of stroke. | 12529745 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes. | 12535753 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Endothelial activation and acute-phase reaction correlate with insulin resistance and obesity in type 2 diabetic patients. | 12535753 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance and risk of chronic kidney disease in nondiabetic US adults. | 12538749 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The prevalence of CKD was significantly and progressively higher with increasing levels of serum insulin, C-peptide, HbA1c, and HOMA-insulin resistance. | 12538749 |
| Increased insulin level, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | These findings combined with knowledge from previous studies suggest that the insulin resistance and concomitant hyperinsulinemia are presented in CKD patients without clinical diabetes. | 12538749 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Further studies into the causality between insulin resistance and CKD are warranted. | 12538749 |
| Coronary Arteriosclerosis, Myocardial Ischemia | Deregulated Nutrient Sensing | Prospective studies have indicated that hyperinsulinaemia/insulin resistance is a risk factor for ischaemic heart disease (IHD), the risk decreasing with time of follow-up. | 12542553 |
| diabetic | Deregulated Nutrient Sensing | Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects. | 12547850 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The combined rates of glucose intolerance (diabetes, IGT, and IFG) were 32.3% (27.8-36.7%) for women and 49.8% (43.1-56.4%) for men (P < 0.0001). | 12547854 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes and glucose intolerance is extremely high among adult Arab Americans in Michigan and represents a major clinical and public health problem. | 12547854 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atorvastatin treatment in diabetic dyslipidemia results in a significant dose-dependent decrease in HL activity, regardless of sex or the LIPC promoter variant. | 12547874 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | These results show that the C242T mutation in the p22 phox gene is associated with progression of asymptomatic atherosclerosis in the subjects with type 2 diabetes and is also associated with insulin resistance in nondiabetic subjects. | 12547880 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | 1) Visceral obesity, more than age per se, correlates with glucose intolerance in middle-aged subjects; 2) aging does not influence in vitro adipose tissue glucose uptake. | 12547885 |
| Traumatic injury | Deregulated Nutrient Sensing | Insulin resistance after surgery is caused by the surgical trauma and presumably also by other factors, such as starvation and immobilization. | 12553947 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These observations reinforce the importance of visceral obesity in the pathogenesis of dyslipidemia in men, and they suggest that visceral AT and liver fat carry independent health risk. | 12554597 |
| Increased insulin level, Metabolic Diseases, Cardiovascular Diseases, Prostate Cancer Outcomes Study, Obesity, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is considered a metabolic disorder closely related to obesity, insulin resistance (IR), hyperinsulinemia and unfavorable lipid profile, all increasing the risk for the occurrence of cardiovascular diseases. | 12557616 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin treatment was started for his diabetes together with a special diet for dyslipidemia. | 12557965 |
| Hypertriglyceridemia, Dyslipidemias, Coronary Artery Vasospasm, Angina Pectoris, Variant | Deregulated Nutrient Sensing | We conclude that patients with coronary spastic angina had smaller LDL particles, associated not with hypertriglyceridemia but low serum levels of both HDL-cholesterol and vitamin E. Dyslipidemia with small, dense LDL may be related to the genesis of coronary vasospasm. | 12559540 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Leukocyte angiotensin II levels inpatients with essential hypertension:relation to insulin resistance. | 12559679 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is involved in the pathogenesis of type 2 diabetes, hypertension, and atherosclerosis. | 12559679 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Angiotensin (Ang) converting enzyme inhibitors and Ang II type 1 receptor antagonists improve insulin resistance in patients with essential hypertension, which suggest that tissue Ang II is involved in insulin resistance in patients with hypertension. | 12559679 |
| Dyslipidemias, Kidney Diseases, Cardiovascular Agents | Deregulated Nutrient Sensing | Dyslipidemia frequently complicates chronic nephropathies and increases the risk of renal and cardiovascular events. | 12566371 |
| Adolescent (age group), Prostate Cancer Outcomes Study, HIV, Lipodystrophy, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | To report a case of polycystic ovary syndrome (PCOS) in an adolescent infected with human immunodeficiency virus (HIV) and lipodystrophy whose insulin resistance was induced by highly active antiretroviral therapy (HAART). | 12568857 |
| Lipodystrophy, Obesity, Abdominal | Deregulated Nutrient Sensing | After 34 months of HAART this adolescent showed lipodystrophy with central obesity and insulin resistance after oral glucose tolerance test (OGTT). | 12568857 |
| Lipodystrophy, Hirsutism, Amenorrhea, Acne | Deregulated Nutrient Sensing | After 56 weeks of HAART, the adolescent showed more severe evidence of lipodystrophy and insulin resistance, and she developed acne, hirsutism, and amenorrhea. | 12568857 |
| Lipodystrophy | Deregulated Nutrient Sensing | Lipodystrophy and insulin resistance are well-recognized side effects of HAART. | 12568857 |
| Lipodystrophy, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome might be an additional side effect secondary to insulin resistance and lipodystrophy. | 12568857 |
| Metabolic Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | On the other hand, 28% of the population was treated for known metabolic chronic diseases (CVD, diabetes, dyslipidemias and hypertension), whereas the remaining 33% of the Quebec population (BMI greater than 25 kg/m2) were characterized by an altered metabolic profile predictive of an increased CVD risk. | 12571695 |
| Coronary heart disease | Deregulated Nutrient Sensing | [Relation between insulin resistance and A1166C molecular variant of type 1 angiotensin II receptor gene in patients with coronary heart disease]. | 12575209 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | No significant association between A1166C molecular variant of AT1R gene and insulin resistance was found in Chinese with CHD. | 12575209 |
| Tumor necrosis, Cerebral Hemorrhage | Deregulated Nutrient Sensing | [Effects of nao-yi-an on tumor necrosis factor alpha and insulin resistance of acute intracerebral hemorrhagic patients]. | 12575232 |
| Coronary heart disease | Deregulated Nutrient Sensing | [Preliminary study on relationship between TCM syndrome-type and insulin resistance in coronary heart disease]. | 12575550 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To observe the relationship between TCM Syndrome-type and insulin resistance (ISR) in coronary heart disease (CHD). | 12575550 |
| Hyperinsulinism, Liver Cirrhosis | Deregulated Nutrient Sensing | Patients with cirrhosis of the liver suffer from hyperinsulinaemia and a certain degree of insulin resistance. | 12577452 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Despite hyperinsulinaemia which persisted for one month after the operation, the insulin resistance did not deteriorate. | 12577452 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidaemia variables were closely related and loaded on the same factor. | 12581260 |
| Blood coagulation, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | [Study on stroke syndrome of Chinese medicine and its relationship with blood hypercoagulative status and insulin resistance in diabetic ischemic stroke patients]. | 12585102 |
| Blood coagulation, Ischemic stroke, Syndrome | Deregulated Nutrient Sensing | To study the relationship of TCM Syndromes, involving Viscera Syndrome and involving Meridian Syndrome, with blood hypercoagulative state and insulin resistance in patients with diabetic ischemic stroke. | 12585102 |
| Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | There is close relationship between blood hypercoagulative state, insulin resistance and TCM Stroke Syndromes in patients with diabetic ischemic stroke. | 12585102 |
| Coronary heart disease | Deregulated Nutrient Sensing | [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. | 12585165 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To explore the effect of puerarin in improving the insulin resistance (IR) and its closely related abnormal lipid and fibrinolytic activity in patients with coronary heart disease (CHD). | 12585165 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus was defined as glucose intolerance treated either dietary, with oral hypoglycemics or with insulin. | 12587082 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Our data contradict previous findings suggesting an increased risk for insulin resistance, type II diabetes and atherosclerotic vascular disease in carriers of the mutation. | 12588284 |
| Arteriosclerosis | Deregulated Nutrient Sensing | Association between insulin resistance and carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance. | 12588774 |
| Dental Plaque | Deregulated Nutrient Sensing | In normal-type subjects, univariate analysis showed that insulin resistance, but not insulin secretion, was associated with the presence of carotid plaque. | 12588774 |
| Arteriosclerosis | Deregulated Nutrient Sensing | These data suggest the possibility that the presence of higher insulin resistance could be a risk factor for carotid arteriosclerosis in subjects with normal fasting glucose and normal glucose tolerance. | 12588774 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance of the mothers was associated with an early middle-aged onset of diabetes, reduction in the insulin secretory capacity, early requirement of insulin therapy, and increases in the daily insulin dose. | 12590018 |
| Cardiomyopathies | Deregulated Nutrient Sensing | This study suggests a direct link between insulin resistance and acromegalic cardiomyopathy. | 12590638 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose tolerance normalized in patients with preoperative glucose intolerance (n=7) or diabetes mellitus (n=3). | 12590638 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease. | 12591951 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | These data demonstrate that low glucose disposal rates are robustly associated with the development of diabetes in the FH+ individuals, but insulin resistance per se is not sufficient for the development of diabetes in individuals without family history of disease and strongly suggest a familial factor, not detectable in our current measures of the dynamic responses of glucose or insulin to an IVGTT is an important risk factor for type 2 diabetes. | 12591951 |
| Increased insulin level | Deregulated Nutrient Sensing | Besides hyperinsulinemia, they had insulin resistance and impaired carbohydrate tolerance. | 12592900 |
| Obesity | Deregulated Nutrient Sensing | Association of plasminogen activator inhibitor-1 with insulin resistance in Japan where obesity is rare. | 12601637 |
| Obesity | Deregulated Nutrient Sensing | PAI-1 levels are associated with insulin resistance, irrespective of obesity. | 12601637 |
| Metabolic Diseases | Deregulated Nutrient Sensing | This associated metabolic disorder includes peripheral insulin resistance, which may be caused by factors produced by the PC. | 12604916 |
| Glucose Intolerance (disease), Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance or overt diabetes occurs in 80% of patients with pancreatic cancer (PC). | 12604916 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | There is substantial but not conclusive evidence that insulin resistance is related to left ventricular mass (LVM) in hypertensive individuals. | 12608937 |
| Insulin Secretion | Deregulated Nutrient Sensing | This study compared both categories with respect to the degree of insulin secretion abnormalities and insulin resistance. | 12610051 |
| Deficit, teratologic | Deregulated Nutrient Sensing | Our cross-sectional data from the RIAD study demonstrate that isolated IFG and isolated IGT are different with respect to the degree of insulin resistance and anomalies in insulin secretion, and that subjects with IGT exhibit a deficit in the early and late phases of insulin secretion. | 12610051 |
| diabetic | Deregulated Nutrient Sensing | Whether the adipocyte-derived protein adiponectin is associated with insulin resistance independently of the effects of adiposity and the diabetic state is an important question. | 12611616 |
| Hypoadiponectinemia, Atherosclerosis | Deregulated Nutrient Sensing | Because adiponectin is thought to have an anti-atherogenic action, the presence of hypoadiponectinemia may predispose subjects to atherosclerosis, and may progress the atherogenesis in insulin resistance. | 12611616 |
| Disturbance, Dyslipidemias | Deregulated Nutrient Sensing | A large prevalence of body weight disturbances and high frequency of dyslipidemias are the main characteristics of this population. | 12616806 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension was found in 47% and dyslipidemia in 55%; 69% were smokers. | 12616807 |
| Atherosclerosis | Deregulated Nutrient Sensing | Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. | 12624279 |
| Atherosclerosis | Deregulated Nutrient Sensing | Although these findings suggest an association with insulin resistance and atherosclerosis, this hypothesis has yet been tested only partially. | 12624279 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with smoking habit, dyslipidaemia and diabetes mellitus were excluded from the study. | 12624606 |
| Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | In total, 907 participants, 537 hypertensive and 370 nonhypertensive, from 311 Taiwanese families were drawn from the Stanford Asia and Pacific Program for Hypertension and Insulin Resistance for the study. | 12624610 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Low birth weight has been linked to insulin resistance and cardiovascular disease. | 12629115 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings suggest that resistin may play a role in the pathogenesis of type 2 diabetes and insulin resistance-related hypertension. | 12629116 |
| Proteinuria, Glucose Intolerance (disease), Glomerulosclerosis (disorder) | Deregulated Nutrient Sensing | In addition, glucose intolerance and proteinuria for men were found to be significant risk factors for glomerular sclerosis. | 12631368 |
| Proteinuria, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In addition, glucose intolerance, total cholesterol, ECG abnormalities, and proteinuria affect either glomerular or vascular changes. | 12631368 |
| Demographics Domain, Diabetes Mellitus, diabetic | Deregulated Nutrient Sensing | Moreover, patients were further categorized into normal fasting glucose and glucose intolerance (diabetes mellitus (DM) and impaired fasting glucose) according to the diagnostic criteria of American Diabetic Association. | 12632506 |
| Glucose Intolerance (disease), Hepatitis C, Chronic | Deregulated Nutrient Sensing | In conclusion, 34.6 % of Chinese patients with chronic hepatitis C had glucose intolerance. | 12632506 |
| Glucose Intolerance (disease), Hepatitis C, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic hepatitis C patients who were older in age, obese, had previous IFN treatment history and had family history of diabetes were prone to develop glucose intolerance. | 12632506 |
| Polycystic Ovary Syndrome, Pituitary Adenoma, Disorder of endocrine ovary | Deregulated Nutrient Sensing | Inhibition of growth hormone excess reduces insulin resistance and ovarian dysfunction in a lean case of polycystic ovary syndrome with a growth-hormone-producing pituitary adenoma. | 12637795 |
| Obesity, Abdominal, Atherosclerosis | Deregulated Nutrient Sensing | The Trp64Arg variant of the beta3-adrenergic receptor gene is reported to be associated with abdominal obesity and resistance to insulin, and as a consequence, this variant may be a genetic factor in the development of atherosclerosis. | 12647276 |
| Hyperglycemia, Hypertensive (finding), Dyslipidemias, Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | Hyperglycemia and/or dyslipidemia, even mild, seem to increase the risk of VA in the hypertensive patient with or without LVH. | 12652262 |
| Hyperglycemia | Deregulated Nutrient Sensing | Based on our study and published data, a putative pathogenic pathway was suggested: LPL enzyme deficiency causes elevated plasma triglyceride level and subsequent insulin resistance; both increased free fatty acids and insulin resistance promote gluconeogenesis and hyperglycaemia, a vicious circle leading to type 2 diabetes. | 12655575 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Independent of other factors, important contributors to obesity and dyslipidemia in this population were dietary factors such as meat (p < 0.001) and fish (p < 0.05), and a lower REE (p < 0.05). | 12656207 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These findings suggest that unhealthy diet and lower energy expenditure are important contributors to obesity and dyslipidemia in Tanzania. | 12656207 |
| Glycogen Storage Disease Type V, Obesity | Deregulated Nutrient Sensing | [McArdle's disease with insulin resistance caused by obesity]. | 12661110 |
| Glycogen Storage Disease Type V | Deregulated Nutrient Sensing | We reported a 29-year-old woman with McArdle's disease accompanied with insulin resistance. | 12661110 |
| Obesity | Deregulated Nutrient Sensing | Her obesity might be a causative factor of insulin resistance. | 12661110 |
| Uremia, HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | Multiple logistic regression analysis showed that independent risk factors of AOL of cerebral arteries were uremic state, dyslipidemia, and age in all subjects and dyslipidemia and age in HD patients (R.2=0.162, p=0.0004; R.2 =0.138, p=0.0145, respectively). | 12662216 |
| HD Term Type, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Our findings suggest that chronic renal failure maintained by hemodialysis increases the prevalence of AOL, and that age and dyslipidemia are also significantly associated with AOL in HD patients. | 12662216 |
| deficiency aspects, Diabetes Mellitus | Deregulated Nutrient Sensing | Further study may address whether diabetes is causally associated with insulin deficiency or insulin resistance. | 12663569 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Subjects with IPH exhibited distinctly impaired early-phase insulin secretion and only mild insulin resistance, indicating that reduced insulin secretion is the primary determinant of deterioration from NGT to IGT and IPH in development of type 2 diabetes in these subjects. | 12663599 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Decreased synthesis of nitric oxide (NO) and dyslipidemia are implicated in the development of atherosclerosis. | 12666069 |
| Hyperlipidemia, Myocardial Ischemia, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Homocysteine is a risk factor for ischemic heart disease; similarly as is hyperlipidemia or insulin resistance, which frequently occur in women with polycystic ovary syndrome. | 12667010 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | We conclude that homocysteine is increased in women with polycystic ovary syndrome and is probably linked to androgen levels but not to markers of insulin resistance or with lipid metabolism. | 12667010 |
| Dyslipidemias | Deregulated Nutrient Sensing | Lp(a) levels vary in different dyslipidaemias according to the underlying disease. | 12668913 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In animals, acceleration of neonatal growth is thought to increase the later propensity to insulin resistance and non-insulin-dependent diabetes, whereas slow growth as a consequence of undernutrition is thought to have a beneficial effect. | 12672313 |
| Obesity | Deregulated Nutrient Sensing | The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men. | 12673785 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The Pro12Ala PPARgamma2 polymorphism has been variably associated with obesity, insulin sensitivity, and dyslipidemia. | 12673785 |
| Glucose Intolerance (disease), Amenorrhea, Oligomenorrhea, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes and glucose intolerance were statistically significantly associated with amenorrhea and oligomenorrhea. | 12679164 |
| methionine | Deregulated Nutrient Sensing | In obese, insulin-resistant patients with T2DM who are inadequately controlled on MET, the addition of an agent that reduces insulin resistance may be a more rational and innovative approach than the addition of an insulin secretagogue. | 12681023 |
| Dyslipidemias | Deregulated Nutrient Sensing | Two lipid abnormalities--increased cholesterol and atherogenic dyslipidemia--are potential targets of lipid-lowering therapy. | 12686335 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Patients with chronic renal failure commonly suffer from a secondary form of complex dyslipidaemia, and may benefit from lipid-lowering treatment. | 12686673 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Recently, serum GGT concentrations have been associated with many cardiovascular disease risk factors or components of the insulin resistance syndrome. | 12687334 |
| Hypertension, CTCAE, Psychiatric, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, we find unethical do not treat hypertension, dyslipidemia and diabetes in severe psychiatric patients. | 12693284 |
| Dyslipidemias, Chronic Kidney Diseases, Corneal Endothelial Cell Loss | Deregulated Nutrient Sensing | The relationships between plasma ADPN, serum cholesterol, and serum albumin suggest that this adipocyte protein may serve to mitigate endothelial damage triggered by dyslipidemia and other risk factors in patients with chronic renal diseases. | 12694320 |
| Malignant neoplasm of endometrium, Neoplasms | Deregulated Nutrient Sensing | Tumor estrogen content in endometrial cancer has clinical significance that is modified in the presence of certain endocrine characteristics related to insulin resistance. | 12695909 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | In light of the fact that the development of insulin resistance in adipocytes is responsible for the excessive free fatty acid flux that gives rise to the diabetic syndrome, a favorable impact of ACE inhibition on adipocyte insulin responsiveness - complemented by a potentiation of the direct action of bradykinin on skeletal muscle - offers a satisfying explanation for the prevention of diabetes observed during ACE inhibitor therapy. | 12699703 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The transition from IGT to diabetes was accompanied by a progressive deterioration of insulin reserve as well as insulin resistance. | 12701062 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In conclusion, both impaired insulin secretion and insulin resistance may contribute to the underlying mechanisms of glucose intolerance in Japanese subjects. | 12701062 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Presence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes. | 12706317 |
| Increased insulin level | Deregulated Nutrient Sensing | Insulin resistance was estimated using HOMA(IR), basal hyperinsulinemia and I(0)/G(0) ratio. | 12706317 |
| Alzheimers Disease", Dyslipidemias, Data types - Address | Deregulated Nutrient Sensing | The statin treatment of dyslipidemia is associated with a reduced risk of development of Alzheimer disease (AD). | 12707064 |
| Metabolic Diseases, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Metabolic disorders were found in 97% of the non-steatosis patients (overweight: 40%, perturbed sugar metabolism: 47%, dyslipidemia: 79.5%). | 12712916 |
| Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | The prevalences were: overweight, 67.8%; obesity, 14.4%; central obesity, 72.2%; hypertension, 4.4%; dyslipidemia, 44.4%; hyperuricemia, 5.6%; GAD65 antibody positivity, 4.4%; smoking, 25.6%; chronic alcohol use, 0.0%. | 12713144 |
| Non-insulin Hypoglycemic, Obesity, Abdominal, Premature coronary artery atherosclerosis, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease | Deregulated Nutrient Sensing | So the higher incidence of non-insulin dependent diabetes mellitus with central obesity suggesting insulin resistance along with unique profile of dyslipidemia, higher incidence of smoking and familial predisposition of premature coronary artery disease may be responsible for higher incidence of coronary artery disease at a premature younger age in this population. | 12715632 |
| Autonomic nervous system disorders | Deregulated Nutrient Sensing | These findings suggest that marked autonomic dysfunction, rather than other confounding factors, is related to increased insulin resistance in DM. | 12716078 |
| Hyperlipidemia, Glucose Intolerance (disease), Ventricular Fibrillation, Hypertension, CTCAE | Deregulated Nutrient Sensing | Visceral-fat (VF) accumulation is suggested to be a major contributor to such cardiovascular-disease risk factors as hypertension (H), glucose intolerance (G), and hyperlipidemia (L). | 12716082 |
| Wolff-Parkinson-White Syndrome, Autosome, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | Mutations in the PRKAG2 gene that encodes the gamma2 regulatory subunit of AMP-activated protein kinase have been shown to cause autosomal dominant Wolff-Parkinson-White (WPW) syndrome associated with hypertrophic cardiomyopathy. | 12716108 |
| LMNA wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with FPLD are predisposed to metabolic complications of insulin resistance such as diabetes. | 12716787 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We found that glycemic status influenced LDL oxidizability, with a paradoxical reduction in LDL oxidizability, as indicated by a lower LDL oxidation rate with increased extent and duration of glucose intolerance. | 12716803 |
| Obesity | Deregulated Nutrient Sensing | To estimate leptin production in long-term steroid therapy, insulin resistance and obesity. | 12718213 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. | 12719377 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Risk factors for coronary heart disease (CHD), including prethrombotic changes in hemostasis, cluster with the insulin resistance (IR) syndrome. | 12724002 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Prevalence of hypertension was higher in subjects with glucose intolerance. | 12725257 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. | 12727934 |
| Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Peripheral Vascular Diseases | Deregulated Nutrient Sensing | Utilization of lipid-lowering drugs in elderly persons with increased serum low-density lipoprotein cholesterol associated with coronary artery disease, symptomatic peripheral arterial disease, prior stroke, or diabetes mellitus before and after an educational program on dyslipidemia treatment. | 12730252 |
| Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Peripheral Vascular Diseases | Deregulated Nutrient Sensing | We report the prevalence of use of lipid-lowering drugs in elderly persons with increased serum low-density lipoprotein (LDL) cholesterol associated with coronary artery disease (CAD), symptomatic peripheral arterial disease (PAD), prior stroke, and diabetes mellitus before and after an educational program on the treatment of dyslipidemia. | 12730252 |
| Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus | Deregulated Nutrient Sensing | A 5-month educational program on dyslipidemia treatment given to physicians and nurse practitioners in an academic nursing home improved the prevalence of use of lipid-lowering drugs in persons with increased serum LDL cholesterol associated with CAD, symptomatic PAD, prior stroke, and diabetes mellitus. | 12730252 |
| Dyslipidemias, Poliomyelitis | Deregulated Nutrient Sensing | Polio patients have a high prevalence of dyslipidemia. | 12736884 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Of patients not at target levels, 14.4%, 27.5%, and 86.7% reported receiving no therapy for hyperglycemia, hypertension, and dyslipidemia, respectively. | 12741441 |
| Glucose Intolerance (disease), Hepatitis C, Liver Cirrhosis | Deregulated Nutrient Sensing | Taken together, the findings indicate that cirrhosis appears to be a more important predictor of glucose intolerance than HCV infection, and the combination of both factors increases the risk of DM in our populations. | 12743775 |
| Obesity | Deregulated Nutrient Sensing | Mutations in the peroxisome proliferator-activated receptor-gamma 2 (PPAR-gamma 2) gene may cause obesity and insulin resistance. | 12746759 |
| Steatohepatitis | Deregulated Nutrient Sensing | The aim of study was to investigate whether or not insulin resistance exists in patients with steatohepatitis. | 12749246 |
| Steatohepatitis | Deregulated Nutrient Sensing | Our findings demonstrate that insulin resistance does exist in patients with steatohepatitis and the pathophysiological mechanisms causing resistance is not clear but insulin action is an issue of further investigation. | 12749246 |
| Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Mitochondrial dysfunction in the elderly: possible role in insulin resistance. | 12750520 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly. | 12750520 |
| Dyslipidemias, Diabetes Mellitus, Anemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Other cardiovascular risk factors analyzed were arterial hypertension, diabetes mellitus, obesity, cigarette smoking, anemia, and dyslipidemia. | 12753281 |
| Cancer-related fatigue, Diabetic Nephropathy, Dyslipidemias, diabetic, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | An increase of VLDL apo CIII is a prominent feature of dyslipidemia in CRF patients, regardless of whether they are diabetic or nondiabetic, whereas an increase of VLDL apo CI is more specific to diabetic nephropathy and is closely associated with an increase of VLDL particle numbers, a new risk factor for CHD. | 12753304 |
| Muscle hypertrophy | Deregulated Nutrient Sensing | Vascular hypertrophy and insulin resistance have been associated with abnormal left ventricular (LV) geometry in population studies. | 12756402 |
| Hypertrophy | Deregulated Nutrient Sensing | In conclusion, insulin resistance was not related to LV hypertrophy or reduced LV function. | 12756402 |
| Hypertension, CTCAE, Hereditary | Deregulated Nutrient Sensing | [Is insulin resistance a common pathway for hereditary and environmental factors-induced hypertension?]. | 12757656 |
| Hypertension, CTCAE, Hereditary | Deregulated Nutrient Sensing | Insulin resistance is a common route for hereditary and environmental factors to induce hypertension. | 12757656 |
| Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertriglyceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance: evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes. | 12759893 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | This effect may partially be relevant to the clinical benefits of gemfibrozil in the treatment of dyslipidemia and atherosclerosis. | 12763281 |
| Dyslipidemias, Atherosclerosis, diabetic | Deregulated Nutrient Sensing | Hence our patients are at increased risk of developing atherosclerosis therefore periodic check up of lipids in diabetic patients and effective treatment of the dyslipidemia along with a tight metabolic control was recommended. | 12764995 |
| Breast Carcinoma, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes. | 12766105 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia may be a major contributor in this process and can be influenced by lipid-lowering drugs (statins). | 12768071 |
| Xanthoma, Dyslipidemias | Deregulated Nutrient Sensing | Therefore, in this patient, xanthoma of bone was the first sign of dyslipidemia. | 12771840 |
| Alopecia, Heredity | Deregulated Nutrient Sensing | Hair loss, insulin resistance, and heredity in middle-aged women. | 12775957 |
| Hypercholesterolemia, Coronary Artery Disease, Androgenetic Alopecia | Deregulated Nutrient Sensing | The association of androgenic alopecia (AGA) with insulin resistance, coronary artery disease and hypercholesterolemia has been previously reported in men, but no such association has been reported in women with female androgenic alopecia (AGA). | 12775957 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovarian syndrome is quite common among Caucasian women, and its association with insulin resistance is well documented. | 12775957 |
| Hypertensive (finding), Albuminuria, Metabolic Syndrome X | Deregulated Nutrient Sensing | Albuminuria is independent of insulin resistance and other phenotypic components of the metabolic syndrome in never-treated, non-diabetic essential hypertensive men. | 12777954 |
| Microalbuminuria, Antihypertensive Agents | Deregulated Nutrient Sensing | Microalbuminuria is more frequent in obese hypertensives but this association is explained by higher blood pressure more than insulin resistance. | 12777954 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Although conventional risk factors such as glucose intolerance, hypertension, and dyslipidemia probably contribute, there may also be direct effects of GH/IGF-I excess on the vasculature. | 12788854 |
| Obesity, Visceral, Prostate Cancer Outcomes Study, Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Endocrine System Diseases, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS), a common endocrine disorder of reproductive-aged women, is associated with multiple risk factors for coronary heart disease (CHD), such as diabetes mellitus, dyslipidemia, visceral obesity, and hypertension. | 12788855 |
| Obesity | Deregulated Nutrient Sensing | Several markers of chronic immune activation have been found in association with obesity and insulin resistance. | 12788878 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | There was no relation between SUA and insulin resistance in these hypertensive groups. | 12797630 |
| Dyslipidemias | Deregulated Nutrient Sensing | A systematic secondary preventive strategy may help achieve an adequate control of dyslipidemia in most CAD patients. | 12797928 |
| Insulin resistance syndrome, Electrocardiogram: myocardial infarction (finding), Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | That sex hormones, insulin, and obesity all correlate with the constellation of risk factors for myocardial infarction (MI) that has come to be known as "syndrome X," the "insulin-resistance syndrome," or the "metabolic syndrome" suggests that any one or more of them could underlie and link the risk factors to form the constellation. | 12800107 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Bearing in mind that the main defects in type 2 diabetes mellitus are reduced FPIS and insulin resistance, and the favourable effect vitamin D3 had on them, we suggest vitamin D3 deficiency may at least partly contribute to the impairment of insulin secretion and probably of insulin action. | 12800453 |
| Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance characterizes type 1 diabetes mellitus with nephropathy. | 12803834 |
| diabetic | Deregulated Nutrient Sensing | We measured urinary excretion of PC-1 (alkaline phosphodiesterase I), a potential factor of insulin resistance, and N-acetyl-beta-D-glucosaminidase (NAGA) in 62 type 1 diabetic patients with different damage to the kidney. | 12803834 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a key feature of type 2 diabetes mellitus. | 12803833 |
| Saint Helena Islands, Dyslipidemias, Myocardial Ischemia, Hypothyroidism | Deregulated Nutrient Sensing | The increased risk for ischemic heart disease (IHD) associated with subclinical hypothyroidism (SH) has been partly attributed to dyslipidemia. | 12804105 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | All subjects had type 2 diabetes and a modest dyslipidaemia (mean LDL-cholesterol 3.2 mmol/l and median triglycerides 1.8 mmol/l) and had a previous myocardial infarction. | 12818407 |
| TG gene, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | High apoCIII concentration in apoB lipoproteins is a prominent component of atherogenic dyslipidemia, and explains the risk of coronary heart disease (CHD) associated with high triglyceride (TG). | 12818412 |
| TG gene, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We hypothesized that diabetic people have atherogenic dyslipidemia with apoCIII in excess of that accounted for by their high TG levels. | 12818412 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Sedentarism (87.2%), dyslipidemias (71.5%), high blood pressure (13.5%), obesity (13.1%), smoking (12.4%) and diabetes (2.8%) were the more prevalent RF. | 12818466 |
| Hypertensive disease | Deregulated Nutrient Sensing | The insulin resistance index (HOMA-IR) in the HBP and the NBP groups were 2.49+/-0.2 and 1.95+/-0.13 (p<0.05). | 12819902 |
| Hypertensive (finding), Hyperinsulinism, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | We found clustering of hyperinsulinaemia, insulin resistance and truncal obesity in hypertensive Ghanaian subjects but dissociation between insulin resistance, hypertension and atherogenic lipid and lipoprotein profile. | 12819902 |
| Coma (genus), Glucose Intolerance (disease), Diabetic Ketoacidosis | Deregulated Nutrient Sensing | Severity of disease ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma. | 12820816 |
| Lipodystrophy | Deregulated Nutrient Sensing | These results suggest that adiponectin and the TNFalpha system are related to lipodystrophy, insulin resistance and metabolic alterations in patients under PI-based HAART. | 12824788 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Both women had atherosclerosis risk factors: current smoking, use of estrogen containing pill, dyslipidemia and/or familial cardiovascular history. | 12829221 |
| Kidney Diseases | Deregulated Nutrient Sensing | Increased resistin blood levels are not associated with insulin resistance in patients with renal disease. | 12830457 |
| Kidney Diseases | Deregulated Nutrient Sensing | We explored the potential role of resistin in the pathophysiological process of insulin resistance encountered in patients with renal disease. | 12830457 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2 diabetes mellitus. | 12837046 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this pilot, randomized, double-blind study, we compared the effects of policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia and type 2 diabetes mellitus. | 12837046 |
| Hyperglycemia | Deregulated Nutrient Sensing | Delayed glucose clearance after hyperglycemia may contribute to insulin resistance. | 12840207 |
| Hyperglycemia, Postprandial | Deregulated Nutrient Sensing | In conclusion, modest increases in abdominal adiposity and circulating lipids are associated with abnormal glucose clearance in clinically healthy older men; this may be a precursor to the development of insulin resistance and related complications that arise from prolonged postprandial hyperglycemia. | 12840207 |
| Retinal Vein Occlusion, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance and atherosclerosis in branch retinal vein occlusion. | 12842202 |
| Retinal Vein Occlusion, atherosclerotic | Deregulated Nutrient Sensing | To investigate insulin resistance and atherosclerotic change in patients with branch retinal vein occlusion (BRVO). | 12842202 |
| Dyslipidemias | Deregulated Nutrient Sensing | Efficacy of atorvastatin and gemfibrozil, alone and in low dose combination, in the treatment of diabetic dyslipidemia. | 12843167 |
| Dyslipidemias | Deregulated Nutrient Sensing | This fact forms a contrast with a high degree of dyslipidemia control. | 12848599 |
| Inflammation, Dyslipidemias, Diabetes Mellitus, Obesity, No metabolic abnormalities | Deregulated Nutrient Sensing | On the other hand, several metabolic abnormalities such as dyslipidemia, hyperinsulinemia/insulin-resistance, diabetes, and obesity causes inflammation followed by a later rise in arterial BP. | 12850386 |
| Carotid Atherosclerosis | Deregulated Nutrient Sensing | Indeed, age (P <.001), insulin resistance syndrome score (P =.05), IL-1 beta (P <.05), and severity of carotid atherosclerosis (P <.05) were the only significant predictor of systolic BP. | 12850386 |
| Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | The increased levels of insulin on an empty stomach and in 120-th minute of OGT test at an early stage of diabetes type 2 provide a good insight into insulin resistance disorders, whereas the values of the alfa index of stimulation (the level of insulin in the 60-th minute of OGT test/the level of insulin on an empty stomach) point to a disorder in insulin secretion. | 12858649 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, pediatric post-transplant diabetes may be related to reversible insulin resistance. | 12859535 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Thus, pravastatin reduced potentially atherogenic remnant particles, a prominent component of diabetic dyslipidemia associated with coronary events; these results may contribute to its demonstrated effectiveness in reducing coronary heart disease in diabetics. | 12860210 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | The human adiponectin gene has been implicated in the pathophysiology of obesity, type II diabetes mellitus, dyslipidemia and atherosclerosis. | 12861229 |
| Heart Diseases | Deregulated Nutrient Sensing | Our findings do not support the hypothesis that susceptibility to heart disease in South Asians results from a combination of high insulin resistance and high Lp(a) levels. | 12864778 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Sedentarism (87.2%), dyslipidemias (71.5%), high blood pressure (13.5%), obesity (13.1%), smoking (12.4%) and diabetes (2.8%) were the most prevalent RF. | 12870232 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Obesity, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Glucose intolerance (GI) is preceded by a prolonged period of Insulin Resistance (IR) and is an advanced stage towards the development of Type 2 Diabetes Mellitus (NIDDM), whose incidence is increasing in the pediatric population, along with obesity. | 12870237 |
| Diabetes Mellitus, Dyslipidemias, Overweight, Atherosclerosis | Deregulated Nutrient Sensing | Complications of overweight, such as type-2 diabetes Mellitus, dyslipidemia and diffuse atheromatosis are common. | 12870238 |
| Hyperplastic Polyp, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with diabetes mellitus, dyslipidemia or more than two cardiovascular risk factors, vitamin C decreased endothelial and platelet-derived MP levels by approximately 70% and 13%, respectively. | 12871555 |
| Cushing Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | The dyslipidemia and elevation of lactate dehydrogenase activity in this series indicated the need for routine laboratory testing in Cushing's syndrome patients. | 12874666 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | In Europid populations, low birth weight of offspring predicts insulin resistance in the mother and cardiovascular disease in both parents. | 12882927 |
| Malignant tumor of colon, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is an important risk factor for development of type 2 diabetes as well as other chronic conditions, including hypertension, cardiovascular disease, and colon cancer. | 12882937 |
| Atherosclerosis | Deregulated Nutrient Sensing | We have previously measured insulin action in a large cohort of subjects (Insulin Resistance and Atherosclerosis Study [IRAS] Family Study) using the minimal model approach. | 12882937 |
| Dilated Cardiomyopathy Pathway | Deregulated Nutrient Sensing | Effect of beta-blockers on insulin resistance in patients with dilated cardiomyopathy. | 12890914 |
| Doctor of Chiropractic | Deregulated Nutrient Sensing | Beta-blocker therapy in patients with DCM improved not only cardiac function, but also insulin resistance. | 12890914 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Mucopolysaccharidosis I | Deregulated Nutrient Sensing | However, after adjusting for age, sex, dyslipidemia, diabetes, hypertension and tobacco use, the difference in the prevalence of CAD between the various categories of MPS was not significant. | 12893021 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | The clinical benefits of treating dyslipidemia in patients with diabetes should be at least equivalent to, if not more substantial than, the benefits observed among those with cardiovascular disease. | 12893398 |
| Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance/beta-cell function and serum ferritin level in non-diabetic patients with hepatitis C virus infection. | 12895270 |
| Hepatitis C, Liver diseases | Deregulated Nutrient Sensing | Since impaired glucose tolerance and iron overload are frequently demonstrated in hepatitis C virus (HCV)-related liver diseases, in this study we investigated insulin resistance, pancreatic beta-cell function, i.e., insulin secretion, and serum ferritin levels in patients with HCV infection, especially non-diabetic patients. | 12895270 |
| Hepatitis C, Liver diseases | Deregulated Nutrient Sensing | Insulin resistance was connected with impaired glucose tolerance and the severity of liver diseases in non-diabetic patients with HCV infection. | 12895270 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We demonstrated that fasting insulin levels strongly inversely correlated with QUICKI in three different groups: 215 healthy nondiabetic nonobese subjects, 62 nondiabetic obese subjects, and 44 patients with glucose intolerance or type 2 diabetes mellitus. | 12897376 |
| Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Postprandial hypertriglyceridemia associated with insulin resistance is one of the cardiovascular risk factors in obesity and type 2 diabetes. | 12898471 |
| Tumor necrosis | Deregulated Nutrient Sensing | Allelic variants of the tumor necrosis factor-alpha (TNF-alpha) gene seem to contribute to insulin resistance increasing the transcription rate of TNF-alpha. | 12898475 |
| diabetic | Deregulated Nutrient Sensing | Insulin resistance, parameters of carbohydrate metabolism, anthropometric parameters, interactions in diabetic patients. | 12898939 |
| diabetic | Deregulated Nutrient Sensing | We did not find any significant relationships between insulin resistance and anthropometric parameters in the diabetic group. | 12898939 |
| Vascular Diseases, Lipid Metabolism Disorders, diabetic | Deregulated Nutrient Sensing | [Lipids disorder, macrovascular diseases, and insulin resistance in Chinese diabetic patients]. | 12905764 |
| Lipid Metabolism Disorders | Deregulated Nutrient Sensing | Insulin resistance was more severe in all patients with lipid disorder except in L-HDL group, particularly in the HY-C-T-L-HDL group. | 12905764 |
| Vascular Diseases, Lipid Metabolism Disorders, diabetic | Deregulated Nutrient Sensing | (2) Nearly two thirds of Chinese diabetic patients have lipid disorder, which is the strong risk factor of macrovascular diseases and aggravates insulin resistance. | 12905764 |
| Hypertriglyceridemia, Lipid Metabolism Disorders | Deregulated Nutrient Sensing | (3) There was severe insulin resistance in patients with hypertriglyceridemia or with hypertriglyceridemia plus other lipid disorder. | 12905764 |
| Increased insulin level | Deregulated Nutrient Sensing | [Compensated hyperinsulinemia based on selective insulin resistance predicts elevation of blood pressure in non-diabetic adults]. | 12905769 |
| Increased insulin level | Deregulated Nutrient Sensing | To investigate if hyperinsulinemia or insulin resistance could predict the elevation of blood pressure in non-diabetic adults. | 12905769 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Possible contributing factors are elevated blood pressure values, changes in vascular reactivity, concentrations of lipids, fibrinogen and carboxyhemoglobin, in patients with diabetes mellitus, the quality of diabetes control and insulin resistance. | 12911864 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance, and impaired beta-cell function. | 12915397 |
| Hypokalemia, Cushing Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | This case is unusual in that the patient was relatively young and the clinical presentation of Cushing's syndrome was dominated by uncontrolled diabetes, insulin resistance, and hypokalemia. | 12917066 |
| Postmenopausal state | Deregulated Nutrient Sensing | Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial. | 12917202 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The increase in blood pressure that accompanies the obese state is almost invariably associated with alterations in metabolism (insulin resistance and dyslipidaemia) and the neurohumoral profile (activation of the renin-angiotensin system, sympathetic overactivity), which potentiate the cardiovascular risk associated with hypertension. | 12923410 |
| Obesity | Deregulated Nutrient Sensing | Obesity is characterised by a marked insulin resistance which involves an abnormal regulation of K(+) uptake and metabolism. | 12923648 |
| Obesity | Deregulated Nutrient Sensing | The present data can be interpreted in the light of the insulin resistance syndrome of obesity, which causes an abnormal regulation of the Na-KATPase and of K(+) channels during physical exercise. | 12923648 |
| Pancreatitis, Dyslipidemias, Liver diseases | Deregulated Nutrient Sensing | In conclusion, Alstrom syndrome is a disease of systemic multi-organ involvement, and hepatic disease and pancreatitis, possibly due to dyslipidemia, appear to be manifestations of Alstrom syndrome. | 12926522 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, intramyocellular lipid content, and plasma adiponectin in patients with type 1 diabetes. | 12933352 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a key pathogenic factor of type 2 diabetes (T2DM); in contrast, in type 1 diabetes (T1DM) it is considered a secondary alteration. | 12933352 |
| Hyperglycemia | Deregulated Nutrient Sensing | In conclusion, in T1DM, T2DM, and OFF, IMCL content was associated with insulin resistance, demonstrating that IMCL accretion is a marker of insulin resistance common to both primary genetically determined and secondary metabolic (chronic hyperglycemia) alterations. | 12933352 |
| Acute myocardial infarction | Deregulated Nutrient Sensing | The effect of insulin resistance (IR) on the fatty acid metabolism of myocardium, and therefore on the recovery of left ventricular (LV) wall motion, has not been established in patients with acute myocardial infarction (AMI). | 12939551 |
| Heart Diseases, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Dyslipidemias, hypertension, obesity, cigarette smoking and cardiac diseases were found to be the most prevalent single risk factors. | 12940842 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | [Effect of oral inulin administration on lipid profile and insulin sensitivity in subjects with obesity and dyslipidemia]. | 12942586 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin lispro reduces insulin antibodies in a patient with type 2 diabetes with immunological insulin resistance. | 12951276 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Drug therapy management (DTM) for patients with dyslipidemias identified frequent drug therapy problems associated with both hyperlipidemia and other conditions. | 12952316 |
| Acromegaly | Deregulated Nutrient Sensing | Evaluation of insulin resistance in acromegalic patients before and after treatment with somatostatin analogues. | 12952367 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Endothelial dysfunction and insulin resistance have been strongly associated with reduced vascular reactivity in T2DM. | 12954157 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Relation of insulin resistance to markers of preclinical cardiovascular disease: the Strong Heart Study. | 12955795 |
| Hypercholesterolemia, Glucose Intolerance (disease), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The prevalence of severe hypertension and current smoking significantly decreased, while that of glucose intolerance, hypercholesterolemia, and obesity greatly increased among the cohorts. | 12958323 |
| Disease | Deregulated Nutrient Sensing | To determine whether serum gamma GTP activity could be associated with the status of various disorders caused by increased insulin resistance levels, namely, insulin resistance syndrome, a cross-sectional study for 11,884 Japanese men was performed. | 12960502 |
| Inflammation, Dyslipidemias, Venous Thromboembolism, vinyltriethoxysilane | Deregulated Nutrient Sensing | Venous thromboembolism (VTE) involves inflammation and a relation with dyslipidemia which remains controversial. | 12969812 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A low birth weight is associated with insulin resistance and type 2 diabetes. | 12974743 |
| Atherosclerosis | Deregulated Nutrient Sensing | These results indicate that doxazosin can be used safely in patients with insulin resistance, while its positive effect on endothelial function may lessen the subsequent incidence of atherosclerosis. | 14506621 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Acanthosis Nigricans, Lipodystrophy | Deregulated Nutrient Sensing | The lipodystrophy causes severe insulin resistance, resulting in acanthosis nigricans, diabetes, dyslipidaemia, and increased risk of cardiovascular disease. | 14510863 |
| Acromegaly | Deregulated Nutrient Sensing | In acromegalic patients, somatostatin analogues treatment reduces insulin resistance, and also impairs insulin secretion. | 14510913 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The association of insulin resistance (IR) and essential hypertension is well known, but a causal relationship has not been proven. | 14511355 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance (IR) commonly is associated with nonalcoholic steatohepatitis (NASH). | 14512888 |
| Hepatobiliary Disorder, Fatty Liver Disease | Deregulated Nutrient Sensing | In conclusion, improving insulin sensitivity with rosiglitazone resulted in improved histologic markers of NASH, an observation suggesting that insulin resistance contributes to its development and that improving insulin sensitivity may be important in treating this liver disease. | 14512888 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Among Japanese Americans, CRP may be a risk factor for development of type 2 diabetes independent of either obesity or insulin resistance. | 14514575 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The Accelerator Hypothesis predicts earlier onset in heavier people, without necessarily a change in risk, and views type 1 and type 2 diabetes as the same disorder of insulin resistance, set against different genetic backgrounds. | 14514593 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a function of fat mass, and increasing body weight in the industrialized world has been accompanied by earlier presentation (i.e., acceleration) of type 2 diabetes. | 14514593 |
| Tumor necrosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Leptin and tumor necrosis factor (TNF)-alpha are associated with insulin resistance and cardiovascular disease. | 14514596 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. | 14514631 |
| Weight Gain, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | With intensive therapy, subjects with a family history of type 2 diabetes had greater central weight gain and dyslipidemia characterized by higher triglyceride levels and greater cholesterol in VLDLs and intermediate-density lipoproteins compared with subjects with no family history. | 14514648 |
| Dyslipidemias, Myocardial Ischemia, Hyperuricemia, Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | The choice of antihypertensives in relation to comorbidities and laboratory findings revealed that many hypertensive patients with dyslipidemia were on beta-blockers and diuretics, 39.3% of patients with ischemic heart disease were on beta-blockers, approximately 20% of patients with hyperuricemia were on diuretics, and 27.6% and 10.4% of patients with isolated systolic hypertension were on diuretics and calcium-channel blockers, respectively. | 14519051 |
| Uremia, Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance, a strong risk factor for atherosclerotic vascular disease, is present in uremic patients without diabetes on continuous ambulatory peritoneal dialysis (CAPD) therapy. | 14520628 |
| Cardiac complication | Deregulated Nutrient Sensing | Amelioration of insulin resistance may reduce associated long-term cardiovascular complications. | 14520628 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | ROS improved insulin resistance in CAPD patients without diabetes. | 14520628 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | It is now well recognised that, in addition to total body fat, fat distribution is a major risk factor for cardiovascular disease and insulin resistance/diabetes in both adults and children. | 14522692 |
| Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Kidney transplant recipients are not only prone to dyslipidemia but also have a high risk of cardiovascular death. | 14529894 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Uremic dyslipidemia characterized by reduced high-density lipoprotein (HDL) cholesterol levels is one of the major contributors to the high incidence of cardiovascular disease in hemodialysis patients. | 14531818 |
| Hyperlipidemia, Obesity, Abdominal, diabetic | Deregulated Nutrient Sensing | Unlike the 747 normoglycemic patients, both IFG (n=94) and diabetic (n=267) subjects showed an insulin resistance profile, with abdominal obesity, and dislipidemia characterized by high triglycerides in the presence of low high density lipoprotein-cholesterol and high normal or elevated blood pressure. | 14532941 |
| Dyslipidemias, Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of dyslipidaemia hypertension and diabetes were significantly increased in overweight and obese groups. | 14535102 |
| Dyslipidemias | Deregulated Nutrient Sensing | Ragaglitazar is a novel dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist intended to restore insulin sensitivity and correct diabetic dyslipidemia. | 14551179 |
| Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance and other risk factors for coronary heart disease in elderly men. | 14555884 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The risk of CHD increased 2.5-fold in known diabetics compared with those with normal glucose tolerance, 2.2-fold among those in the highest compared with the lowest quintile of insulin resistance, and 2.4-fold among those in the highest compared with the lowest quintile of fasting insulin. | 14555884 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance is a significant risk factor for CHD. | 14555884 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It has been suggested that Japanese, categorized as having normal weight (BMI<25.0), as defined by WHO (2000), have a tendency toward increased incidences of dyslipidemia and diabetes. | 14557832 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The Mongolians had a higher prevalence of obesity and a higher body fat percent, but a lesser gradation of dyslipidemia, than did the BMI-matched Japanese groups. | 14557832 |
| diabetic | Deregulated Nutrient Sensing | Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients. | 14564674 |
| diabetic | Deregulated Nutrient Sensing | These results indicate that not only BMI, HbA(1c), and triglycerides levels but also platelet counts are independent predictor of insulin resistance in non-obese Japanese type 2 diabetic patients. | 14564674 |
| Hypoadiponectinemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus. | 14564678 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | Both subcutaneous and visceral fat accumulation contribute to insulin resistance in these subjects, and the contribution of visceral fat may be mediated, in part, by hypoadiponectinemia. | 14564678 |
| diabetic | Deregulated Nutrient Sensing | Arterial wall thickness is associated with insulin resistance in type 2 diabetic patients. | 14566088 |
| diabetic | Deregulated Nutrient Sensing | The aim of the present study was to investigate the independent association of the intimal-medial thickness of carotid and femoral arteries (CA-IMT and FA-IMT), a marker of atheroscelosis, with insulin resistance in type 2 diabetic patients. | 14566088 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We evaluated CA-IMT and FA-IMT by high-resolution ultrasonography and insulin resistance determined by euglycemic hyperinsulinemic clamp in 119 type 2 diabetic subjects, 71 males and 48 females (age, 54 +/- 12 (SD) years). | 14566088 |
| Diabetes Mellitus, Non-Insulin-Dependent, diabetic, Atherosclerosis | Deregulated Nutrient Sensing | In conclusion, insulin resistance is associated with both CA-IMT and FA-IMT in type 2 diabetic patients, suggesting that it is an independent risk factor for the development of atherosclerosis in type 2 diabetes. | 14566088 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The following variables showed a positive correlation with dyslipidemia: increased age (P<0.001), male sex (P<0.001), low familial income (P<0.001), familial history (P<0.01), overweight/obesity (P<0.001), waist measure (P<0.001), high blood pressure (P<0.001), and diabetes mellitus (P<0.001). | 14569370 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The following prevalences were observed: of dyslipidemias 24.2%; of hypercholesterolemia, 4.2%; of elevated LDL-C, 3.5%; of low HDL-C, 18.3%; and of hypertriglyceridemia, 17.1%. | 14569370 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Sex, age, dyslipidemia, obesity, hypertension, clinic cardiac status, coronary angiographic lesions and coronary revascularisation procedures were noted. | 14573964 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. | 14578226 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Islet amyloid has been suggested to be an important link between insulin resistance and beta-cell dysfunction in type 2 diabetes. | 14578294 |
| Failure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings suggest that islet amyloid deposits reflect greater insulin resistance and islet failure in a subgroup of type 2 diabetic patients. | 14578294 |
| diabetic | Deregulated Nutrient Sensing | Insulin resistance was computed with linear regression based on an equation previously validated in clamp studies on type 1 diabetic adults. | 14578303 |
| SLC25A20 gene, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance was associated with CAC (OR 1.6 in type 1 diabetes and 1.4 in control subjects, P < 0.001), independent of coronary artery disease risk factors. | 14578303 |
| diabetic | Deregulated Nutrient Sensing | After adjusting for insulin resistance, the CAC male excess in diabetic patients decreased from OR 2.2 (P < 0.001) to 1.8 (P = 0.04). | 14578303 |
| Calcification of coronary artery, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, gender differences in insulin resistance-associated fat distribution may explain why type 1 diabetes increases coronary calcification in women relatively more than in men. | 14578303 |
| Diabetes Mellitus, Non-Insulin-Dependent, Disease | Deregulated Nutrient Sensing | Type 2 diabetes is a heterogeneous disorder characterized by defects in the early phase of insulin secretion after meals and in insulin resistance at its early stage. | 14581145 |
| Peripheral Vascular Diseases, Increased insulin level | Deregulated Nutrient Sensing | Although age, FPG, plasma HbA1c, serum total-cholesterol, HDL-cholesterol concentrations, and systolic and diastolic blood pressure were at same levels in group A as group B, body mass index, HOMA-R, serum triglyceride concentrations were significantly higher in group A, indicating the existence of insulin resistance in group A. Hyperinsulinemia may be involved in the development of PVD in moderately hyperglycemic patients. | 14581153 |
| Atherosclerosis | Deregulated Nutrient Sensing | Comparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the Insulin Resistance Atherosclerosis Study (IRAS). | 14581403 |
| Vascular Diseases, Thrombosis, Inflammation, Atherosclerosis, Dyslipidemias, Dysglycemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Risk factors for vascular disease include obesity, dyslipidemia, hypertension, dysglycemia, insulin resistance, inflammation, thrombosis, and subclinical atherosclerosis. | 14581403 |
| Increased insulin level, Thrombosis, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | There were significant differences in measures of abdominal obesity, dyslipidemia, hyperinsulinemia, and thrombosis between subjects with elevated apoB but normal LDLC versus those with elevated LDLC but normal apoB. | 14581403 |
| Diabetes Mellitus, Obesity, Insulin resistance syndrome | Deregulated Nutrient Sensing | These considerations may rationalize recent evidence that high dietary intakes of calcium and/or dairy products may reduce risk for obesity, diabetes, and insulin-resistance syndrome, and they predict that other dietary measures which down-regulate PTH - such as good vitamin D status, and moderation in phosphate and salt intakes - may likewise be beneficial in these respects. | 14592784 |
| Hyperparathyroidism | Deregulated Nutrient Sensing | Consistent with this position are reports that body weight is elevated in elderly subjects with both primary and secondary hyperparathyroidism; furthermore, insulin resistance is a well-known complication of both forms of hyperparathyroidism. | 14592784 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The fact that regular alcohol consumption is associated with decreased PTH secretion may help to explain why moderate drinkers are less prone to insulin resistance, diabetes, and - in women - obesity. | 14592784 |
| Hyperglycemia, Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | Compared with a similar-size subpopulation with high body mass index, persons with EWET were older and had more dyslipidemia, hyperglycemia, and hyperuricemia. | 14594778 |
| Dyslipidemias, Increased insulin level, Prediabetes syndrome, Hyperuricemia | Deregulated Nutrient Sensing | Compared with "prediabetes," EWET identified more persons with hyperinsulinemia, dyslipidemia, and hyperuricemia. | 14594778 |
| Atherosclerosis | Deregulated Nutrient Sensing | Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study. | 14594783 |
| Atherosclerosis | Deregulated Nutrient Sensing | We evaluated data from the Insulin Resistance Atherosclerosis Study (IRAS Exam I, 1992-1994). | 14594783 |
| Hippocampal atrophy, Diabetes Mellitus | Deregulated Nutrient Sensing | We investigated the association between diabetes mellitus, insulin resistance and the degree of hippocampal and amygdalar atrophy on magnetic resonance imaging (MRI) accounting for vascular pathology. | 14595538 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes mellitus and, in non-diabetic subjects, insulin resistance was assessed for 506 participants in whom hippocampal and amygdalar volumes on MRI were measured. | 14595538 |
| Amygdaloid structure | Deregulated Nutrient Sensing | Furthermore, increasing insulin resistance was associated with more amygdalar atrophy on MRI. | 14595538 |
| Fatty Liver, Hyperlipidemia, Diabetes Mellitus, Fatty Liver Disease | Deregulated Nutrient Sensing | When a patient on a glucocorticoid therapy shows signs of fatty liver, diabetes mellitus, hyperlipidemia, an insulin resistance, NASH should be considered as one of the differential diagnosis. | 14598660 |
| Hyperglycemia, No metabolic abnormalities | Deregulated Nutrient Sensing | Apparently, it results from insulin resistance and hyperglycaemia and contributes to coexisting metabolic abnormalities. | 14601484 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Low PON1 has been shown in oxidative stress-associated processes such as dyslipidemia, diabetes mellitus, advancing age, and smoking. | 14602783 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These results suggest that a high intake of alcohol and a decreased P/S ratio contribute to the risk of glucose intolerance in contemporary Japanese. | 14604220 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The observations in dyslipidaemic Asian Indians suggest high prevalence rates of generalized and abdominal obesity, and that high values of W-HR alone predisposes to atherogenic dyslipidaemia. | 14604306 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The revised criteria for the BMI-based diagnosis of obesity will lead to a more rational management of dyslipidaemia in Asian Indians. | 14604306 |
| Dyslipidemias | Deregulated Nutrient Sensing | Measurement or anticipation of patients most susceptible to lipoprotein subfraction abnormalities may influence therapeutic choices for the optimal management of dyslipidemia. | 14605511 |
| HIV Infections | Deregulated Nutrient Sensing | Insulin resistance complicating pregnancy in a human immunodeficiency virus-infected patient treated with protease inhibitors and corticosteroids. | 14607060 |
| Premature Obstetric Labor | Deregulated Nutrient Sensing | We report a case of a pregnant HIV-infected woman receiving highly active antiretroviral therapy who developed acute onset of severe insulin resistance during treatment for preterm labor. | 14607060 |
| Glucose Intolerance (disease), HIV | Deregulated Nutrient Sensing | Protease inhibitor therapy in human immunodeficiency virus (HIV)-infected adults has been associated with onset or aggravation of glucose intolerance. | 14607060 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We found that HIV-positive pregnant women receiving highly active antiretroviral therapy may be at increased risk for development of glucose intolerance. | 14607060 |
| Increased insulin level | Deregulated Nutrient Sensing | Waist-to-hip ratio (WHR) is a marker for insulin resistance and hyperinsulinemia. | 14607804 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients. | 14610526 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The aims of this study were to test the possible association between nonalcoholic fatty liver disease (NAFLD) and iron and insulin resistance, and to determine the prevalence of NAFLD in apparently healthy obese subjects. | 14610526 |
| Fatty Liver | Deregulated Nutrient Sensing | Multiple logistic regression analysis showed waist circumference and insulin resistance to be independently associated with fatty liver. | 14610526 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Serum ferritin level and insulin resistance were two major risk factors predicting NAFLD. | 14610526 |
| Increased insulin level, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | As both hyperinsulinemia induced by insulin resistance and iron overload represented by ferritin elevation might damage hepatocytes, we concluded that these two factors were significantly associated with NAFLD in obese patients.\ | 14610526 |
| TG gene, Dyslipidemias, Federated States of Micronesia | Deregulated Nutrient Sensing | For %FM and FM(trunk)/FM(legs) in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia. | 14610531 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | In males, ORs of the third tertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia. | 14610531 |
| Dyslipidemias, Federated States of Micronesia | Deregulated Nutrient Sensing | Excess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects. | 14610531 |
| insulinoma | Deregulated Nutrient Sensing | Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide. | 14613923 |
| Microunit per Milliliter | Deregulated Nutrient Sensing | South Asians had greater insulin resistance than Europeans (fasting insulin geometric mean, 7.1 versus 4.7 microU/ml, and 2-h insulin, 37.3 versus 14.1 microU/ml, respectively). | 14614356 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | To establish the population-level predictive validity of the Framingham Heart Study risk equation used to derive cardiovascular disease risk-prediction charts for New Zealand management guidelines on raised blood pressure and dyslipidaemia. | 14615804 |
| Obesity | Deregulated Nutrient Sensing | The highest correlations were noted between the insulin resistance factor and the obesity factor (r = 0.887) and the insulin resistance factor and the lipid factor (r = 0.835). | 14617224 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | A higher intensity of medical treatment is needed to achieve BP control in obese hypertensive patients characterized by insulin resistance. | 14620926 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These findings suggest an important role of insulin resistance in predicting the future incidence of hypertension in middle-aged Japanese men. | 14621182 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is more common in overweight individuals and is associated with increased risk for type 2 diabetes mellitus and cardiovascular disease. | 14623617 |
| Weight decreased, Overweight, Obesity | Deregulated Nutrient Sensing | Given the current epidemic of obesity and the fact that lifestyle interventions, such as weight loss and exercise, decrease insulin resistance, a relatively simple means to identify overweight individuals who are insulin resistant would be clinically useful. | 14623617 |
| Overweight, Cardiovascular Diseases | Deregulated Nutrient Sensing | To evaluate the ability of metabolic markers associated with insulin resistance and increased risk for cardiovascular disease to identify the subset of overweight individuals who are insulin resistant. | 14623617 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | Elevated levels of IGFBP-1 in liver disease have been attributed to insulin resistance; however, the relationships between these analytes have not been defined. | 14624764 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, ST3GAL4 gene | Deregulated Nutrient Sensing | We concluded that the new rat model of type 2 diabetes established with conjunctive treatment of low dose of STZ and high fat diet was characterized by hyperglycemia and light impaired insulin secretion function accompanied by insulin resistance, which resembles the clinical manifestation of type 2 diabetes. | 14625406 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | An evaluation of pharmaceutical treatment of dyslipidaemia among patients without diagnosed atherosclerotic disease in Belgium. | 14627185 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is caused by reduced insulin secretion and insulin resistance in skeletal muscle and liver. | 14633813 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | However, this might be reflecting the cluster of risk factors, associated with metabolic syndrome, in which insulin resistance plays a major role. | 14634687 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Intima-media thickness of the carotid arteries in subjects with hyperinsulinaemia (insulin resistance). | 14635730 |
| Hyperinsulinism, Metabolic Syndrome X, Atherosclerosis | Deregulated Nutrient Sensing | The metabolic syndrome is characterised by hyperinsulinaemia (insulin resistance) leading to an increased risk of atherosclerotic cardiovascular diseases. | 14635730 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects were divided into subgroups according to the stages of glucose intolerance (normal glucose tolerance, n = 46; impaired glucose tolerance, n = 26; diabetes mellitus, n = 19). | 14635730 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In hyperinsulinaemic subjects only a trend of increasing IMT values and that of decreasing lumen diameter of the internal carotid arteries were observed when subgroups classified according to the stages of glucose intolerance were compared. | 14635730 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increases in PKC-theta (the major isoenzymic form of PKC in skeletal muscle) protein and isozyme activity have been reported in skeletal muscle from patients with type 2 diabetes mellitus (T2DM) and dietary-induced rodent models of insulin resistance, but the underlying biochemical mechanism is unclear and muscle PKC-theta mRNA expression has not been previously reported in patients with T2DM or in relation to in-vivo measurements of insulin sensitivity. | 14636302 |
| Glucose Intolerance (disease), Acromegaly | Deregulated Nutrient Sensing | Insulin resistance leading, in some cases, to glucose intolerance is an important contributory factor to the cardiovascular morbidity and mortality associated with acromegaly. | 14640992 |
| Steatohepatitis, Cushing Syndrome, Obesity | Deregulated Nutrient Sensing | Hepatic steatosis may occur in association with insulin resistance and obesity, two features commonly seen in Cushing's syndrome (CS). | 14640995 |
| Hypertension, CTCAE, Complications of Diabetes Mellitus, Dyslipidemias | Deregulated Nutrient Sensing | Two hundred and ninety-five patients were divided into the T2DM group (n = 233) and the LADA group (n = 62) to compare the age of onset, body mass index, HbA(1c), C-peptide, hypertension, dyslipidemia and chronic diabetic complications. | 14642146 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Compared with T2DM, LADA patients were younger at their ages of onset, had lower C-peptide and body mass index, and also had less cases with hypertension and with dyslipidemia. | 14642146 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Birthweight of offspring and paternal insulin resistance and paternal diabetes in late adulthood: cross sectional survey. | 14647894 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To confirm this we examined the association between offspring birthweight and paternal insulin resistance and diabetes in late adulthood. | 14647894 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Offspring birthweight is inversely associated with paternal insulin resistance and diabetes in late adulthood, supporting the hypothesis that genetic factors related to insulin action contribute to the association between birthweight and adult cardiovascular disease and diabetes risk. | 14647894 |
| Dyslipidemias | Deregulated Nutrient Sensing | In 62% of 18,627 patients who also had dyslipidemia, low-density lipoprotein cholesterol was less than 130 mg/dL. | 14650370 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Evaluation of human resistin assays with serum from patients with type 2 diabetes and different degrees of insulin resistance. | 14651328 |
| Obesity | Deregulated Nutrient Sensing | Resistin is a peptide hormone encoded at the RSTN gene that since its detection in mice is considered to be an important link between obesity and insulin resistance. | 14651328 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Many of our patients (54%-97%) with dyslipidemia would not have been eligible for inclusion in earlier studies of hyperlipidemia and primary prevention. | 14651827 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of seven health risk indicators (obesity, dyslipidemia, high blood pressure, diabetes mellitus, sedentary lifestyle, smoking, and excessive alcohol use) was assessed. | 14664303 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Four risk indicators (obesity, dyslipidemia, high blood pressure, and sedentary lifestyle) were identified as significant areas of concern. | 14664303 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome. | 14667885 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | To test the interdependence between insulin resistance (IR) and gonadotropin dissociation (GD) in polycystic ovary syndrome (PCOS). | 14667885 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Insulin resistance and GD do not appear to be related events in PCOS, suggesting that each one might be determined by different genetic disorders. | 14667885 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We conclude that improvement of glycemic control in type 2 diabetes improves most of the components of diabetic dyslipidemia, including a shift towards larger LDL particles in subjects with phenotype B. | 14669158 |
| Tumor necrosis | Deregulated Nutrient Sensing | What is the contribution of differences in three measures of tumor necrosis factor-alpha activity to insulin resistance in healthy volunteers? | 14669161 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Association of insulin resistance with depression: cross sectional findings from the British Women's Heart and Health Study. | 14670883 |
| Cushing Syndrome, Adrenal incidentaloma, Overweight | Deregulated Nutrient Sensing | Subclinical Cushing's syndrome (SCS) caused by adrenal incidentalomas is frequently associated with overweight and insulin resistance. | 14671173 |
| Hepatitis B, Chronic, Non-cirrhotic | Deregulated Nutrient Sensing | Mechanisms of increased insulin resistance in non-cirrhotic patients with chronic hepatitis C virus infection. | 14675263 |
| Non-cirrhotic | Deregulated Nutrient Sensing | In the present study, the authors focused on non-cirrhotic and non-diabetic patients with chronic HCV infection and evaluated the factors responsible for increases in insulin resistance. | 14675263 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Homeostasis model assessment of insulin resistance and IRI levels increased parallel with the progression of fibrosis. | 14675263 |
| Inflammation, Fibrosis Assessment, Hepatitis C | Deregulated Nutrient Sensing | Collectively, hepatic fibrosis and inflammation appear to play key roles in the increase in insulin resistance in patients with chronic HCV infection. | 14675263 |
| Hyperhomocysteinemia, Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Within the various patient groups and often despite treatment, there was a high prevalence of hypertension, smoking, dyslipidaemia, hyperhomocystemia and overweight. | 14677480 |
| Diabetes, Autoimmune | Deregulated Nutrient Sensing | Insulin resistance in latent autoimmune diabetes of adulthood. | 14679095 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes. | 14679095 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. | 14679095 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Excessive iron stores may promote insulin resistance and lead to the development of type 2 diabetes. | 14684399 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The independent risk factors associated with the maximum IMT were age, diabetes mellitus, smoking, and intact parathyroid hormone (PTH) (R = 0.569, p < 0.0001), while factors associated with the mean IMT were age, hypertension, dyslipidemia, intact PTH, and lipoprotein (a) (R = 0.602, p < 0.0001). | 14686748 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Diurnal TG profiles can be used to investigate postprandial lipaemia in both lean and mildly obese subjects and may help to detect subjects with an underlying disposition for hypertriglyceridaemia related to insulin resistance, i.e. | 14687241 |
| Diabetes Mellitus, Non-Insulin-Dependent, Blood Glucose | Deregulated Nutrient Sensing | Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects. | 14693409 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a key characteristic of first-degree relatives of patients with type 2 diabetes. | 14693981 |
| Heredity | Deregulated Nutrient Sensing | These results suggest that heredity explains a substantial proportion of the variability of the factors that underlie the insulin resistance syndrome in American Indians and that these factors are genetically independent. | 14694207 |
| Obesity | Deregulated Nutrient Sensing | The pathogenesis has been related to metabolic risk factors, insulin resistance, and obesity. | 14694226 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | This study was designed to examine the relationship between obesity and regional patterns of adiposity, insulin resistance, and five independent measures of subclinical atherosclerosis. | 14694226 |
| Vascular Diseases, Atheroma, Hyperglycemia, Obesity | Deregulated Nutrient Sensing | These findings suggest that obesity may play an important role in the early phase of subclinical macrovascular disease related to vessel stiffness, whereas hyperglycemia and insulin resistance in conjunction with other risk factors have important roles in progression from vessel stiffness to atheroma formation in type 2 diabetes. | 14694226 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and non-traditional cardiovascular (CV) risk factors, such as lipoprotein(a) (Lp(a)), homocysteine, oxidative stress and inflammation, are important determinants in the increased CV risk of hemodialysis (HD) patients. | 14694274 |
| Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity is an important risk factor for the occurrence of coronary artery disease (CAD) in Western countries and furthermore, it often coexists with other CAD risk factors such as hypertension, dyslipidemia and diabetes mellitus. | 14695464 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Associations of measures of lung function with insulin resistance and Type 2 diabetes: findings from the British Women's Heart and Health Study. | 14704837 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Forced expiratory flow in the central period of FVC was not associated with insulin resistance or diabetes. | 14704837 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lung function measures which predominantly reflect lung volume are inversely associated with insulin resistance and Type 2 diabetes. | 14704837 |
| SMN1 wt Allele | Deregulated Nutrient Sensing | High-titre ANA but not SMA positivity is associated with insulin resistance. | 14705824 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Our data suggest that increased circulating insulin, not the state of insulin resistance, suppresses urine 20-HETE excretion in obese hypertensive subjects. | 14707157 |
| Diabetes Mellitus, Acth-Independent Macronodular Adrenal Hyperplasia | Deregulated Nutrient Sensing | Unilateral adrenalectomy improves insulin resistance and diabetes mellitus in a patient with ACTH-independent macronodular adrenal hyperplasia. | 14709842 |
| Microunit per Milliliter | Deregulated Nutrient Sensing | Fasting insulin concentration was increased to 42.6 microU/ml, and the homeostasis model insulin resistance index (HOMA-R) was calculated to be 15.5 (with a normal range of less than 2.5), indicating severe insulin resistance. | 14709842 |
| Glucose Intolerance (disease), Cushing Syndrome | Deregulated Nutrient Sensing | Insulin resistance and glucose intolerance are recognized as features of mild hypercortisolism. | 14709842 |
| Dyslipidemias, Hypopituitarism, Obesity | Deregulated Nutrient Sensing | Dyslipidemia and obesity are common in adult patients with hypopituitarism. | 14709849 |
| Rhabdomyolysis, Dyslipidemias | Deregulated Nutrient Sensing | Although rhabdomyolysis is a rare adverse event associated with this class of drugs, their prevalent use in the management of dyslipidemia makes it increasingly important for clinicians to understand the nature of this condition. | 14712320 |
| Steatohepatitis, dysmetabolic syndrome, Precocious, Diabetes Mellitus | Deregulated Nutrient Sensing | The patient presented also a complex dysmetabolic syndrome characterized by insulin resistance, diabetes mellitus type 2, acanthosis nigricans, liver steatohepatitis, and signs of precocious atherogenesis. | 14715828 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | High doses of testosterone treatment resulted in a severe imbalance in the estradiol to testosterone ratio together with the occurrence of insulin resistance and diabetes mellitus type 2. | 14715828 |
| Acanthosis Nigricans, Steatohepatitis | Deregulated Nutrient Sensing | Estrogen treatment resulted in an improvement of acanthosis nigricans, insulin resistance, and liver steatohepatitis, coupled with a better glycemic control and the disappearance of two carotid plaques. | 14715828 |
| Obesity | Deregulated Nutrient Sensing | Resistin is an adipocyte-derived peptide that might play a role in obesity and insulin resistance. | 14715842 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | In conclusion, plasma resistin concentrations are elevated in patients with type 2 diabetes, but are not associated with insulin resistance or obesity. | 14715842 |
| Obesity | Deregulated Nutrient Sensing | Obesity is characterized by increased leptin levels and insulin resistance, whereas blunted GH secretion is paired with normal, low, or high plasma IGF-I levels. | 14715846 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The present results suggested that radiation dose was related to 1) fatty liver, which clustered the metabolic CHD risk factors associated with insulin resistance syndrome and 2) atherogenic lipid profiles. | 14717339 |
| Periodontitis, Stress | Deregulated Nutrient Sensing | Stress is associated with poor oral hygiene, increased glucocorticoid secretion that can depress immune function, increased insulin resistance and potentially increased risk of periodontitis. | 14719755 |
| Cessation of life, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | When only one of the 3 risk factors, namely hypertension, dyslipidemia and smoking, was present, CVD accounted for 36.8% of all deaths; when all the 3 factors co-existed, CVD accounted for 50% of all deaths. | 14724116 |
| Fibrosis Assessment, Hepatitis B, Chronic | Deregulated Nutrient Sensing | Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]. | 14724822 |
| Hepatitis B, Chronic, fibrogenesis | Deregulated Nutrient Sensing | We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection. | 14724822 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | Hepatitis C virus may induce insulin resistance irrespective of the severity of liver disease, and this effect seems to be genotype specific. | 14724822 |
| Hepatitis C | Deregulated Nutrient Sensing | Further, our findings support the hypothesis that insulin resistance may contribute to fibrotic progression in chronic hepatitis C virus infection. | 14724822 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance plays a major aetiological role in the development of fatty liver disease. | 14725689 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The inverse association between birth weight and CHD may in part be mediated via insulin resistance. | 14729890 |
| HIV-Associated Lipodystrophy Syndrome | Deregulated Nutrient Sensing | This study tested the hypothesis that in patients with HIV-associated lipodystrophy, adiponectin levels were related to insulin resistance, TNF-alpha and IL-6 and treatment with nucleoside analogues. | 14738456 |
| Lipodystrophy, Adipose Tissue Atrophy | Deregulated Nutrient Sensing | In conclusion, the finding of no difference between the two lipodystrophic groups with regard to adiponectin, indicates that low levels of adiponectin reflects fat atrophy, whereas the insulin resistance was best explained by increased truncal fat mass. | 14738456 |
| Obesity | Deregulated Nutrient Sensing | Resistin is thought to be an important link between obesity and insulin resistance. | 14740159 |
| Obesity | Deregulated Nutrient Sensing | It has been suggested that genetic polymorphism in the promoter of resistin gene is a determinant of resistin mRNA expression and possibly associated with obesity and insulin resistance. | 14740159 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of CAD was associated with current, past or passive smoking, a history of diabetes and high blood pressure, a positive family risk factors in this study; levels were below history of CAD, body fat percentage, waist-hip ratio (WHR), low apolipoprotein A1 or low HDL, lipoprotein (a), glucose, insulin, insulin resistance, C-reactive protein (CRP), total cholesterol to HDL ratio (TC/HDL) and creatinine on univariate conditional logistic regression analysis. | 14741073 |
| Periodontal Diseases, Dyslipidemias, Endothelial dysfunction, Cardiovascular Diseases | Deregulated Nutrient Sensing | Based on our data, periodontal disease showed significant associations with biomarkers of endothelial dysfunction and dyslipidemia, which may potentially mediate the association between periodontal and cardiovascular disease. | 14742654 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | Type 2 diabetes is associated with insulin deficiency and insulin resistance and, increasingly, with patients who are overweight or obese. | 14742789 |
| Diabetes Mellitus, Non-Insulin-Dependent, Endothelial dysfunction | Deregulated Nutrient Sensing | In type 2 diabetes, rosiglitazone therapy for insulin resistance ameliorates endothelial dysfunction independent of glucose control. | 14747233 |
| Arteriosclerosis | Deregulated Nutrient Sensing | Insulin resistance is an independent risk factor for arteriosclerosis and cardiovascular mortality. | 14747233 |
| Arteriosclerosis | Deregulated Nutrient Sensing | However, the mechanism by which insulin resistance contributes to arteriosclerosis is unknown. | 14747233 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Therefore, we asked whether therapy for insulin resistance ameliorates any endothelial dysfunction. | 14747233 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a major contributor toward endothelial dysfunction in type 2 diabetes. | 14747233 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Both endothelial dysfunction and insulin resistance are amenable to treatment by rosiglitazone. | 14747233 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | While the incidence of diabetes increases with age, a decrease in beta-cell function independent of age-related insulin resistance has not been conclusively determined. | 14747296 |
| Hyperglycemia | Deregulated Nutrient Sensing | However, after hyperglycemia for an additional 2 h, the ability to maintain insulin secretion, commensurate with the degree of insulin resistance, was decreased in all aging rats (P < 0.05). | 14747296 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | C/IF plaques correlated with age, tobacco consumption, diabetes mellitus, and dyslipidaemia. | 14749711 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Four cardiovascular risk factors seem to be involved in these alterations, namely tobacco consumption, dyslipidaemia, diabetes and increased PP. | 14749711 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. | 14752836 |
| HFE gene, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Obesity, Fibrosis, Liver | Deregulated Nutrient Sensing | Our goal was to define the relative impact of iron overload, genetic mutations of HFE, and insulin resistance on the severity of liver fibrosis in a population of subjects with nonalcoholic fatty liver disease (NAFLD) who had low prevalence of obesity and no overt symptoms of diabetes. | 14752836 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In conclusion, the current study indicates that insulin resistance is a major, independent risk factor for advanced fibrosis in patients with NAFLD. | 14752836 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | We underline strong association with dyslipidemia and obesity. | 14755953 |
| Hypertension, CTCAE, Coronary Arteriosclerosis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We were looking for clinical and biological criteria of diabetes and co-morbidities (hypertension, dyslipidemias, ischaemic heart diseases). | 14755953 |
| Increased insulin level | Deregulated Nutrient Sensing | The uniform pattern of OGTT values was considered due to insulin resistance and hyperinsulinism. | 14755979 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion fenofibrate is the drug which can be choose in diabetic dyslipidemia without cardiac disease. | 14756060 |
| Increased insulin level, Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | The growing recognition that colorectal cancer may be promoted by hyperinsulinemia and insulin resistance suggests that a diet inducing high blood glucose levels and an elevated insulin response may contribute to a metabolic environment conducive to tumor growth. | 14759990 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Exercise blood pressure is related to insulin resistance in subjects with two hypertensive parents. | 14763663 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance has been implicated in the pathogenesis of essential hypertension. | 14763663 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Since elevated blood pressure during physical exertion is a predictor of future hypertension, these findings may suggest that insulin resistance is involved in the pathogenesis of essential hypertension. | 14763663 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The dyslipidemia and insulin resistance of type 2 diabetes can be improved by aerobic exercise. | 14764782 |
| Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | Common associated diseases among these patients were hypertension; 38 (64.4%), ischemic heart disease; 26 (44%), diabetes mellitus; 24 (40.7%), dyslipidemia; 19 (32.2%) and renal insufficiency; 13 (22%). | 14765938 |
| diabetic | Deregulated Nutrient Sensing | Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea. | 14767863 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The degree of insulin resistance in 267 Korean non-obese (body mass index [BMI] < 25 kg/m(2)) >/= patients with type 2 diabetes mellitus was analyzed, and the factors responsible for the insulin resistance were examined. | 14767863 |
| TG gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results suggest that the BMI is the most important determinant of insulin resistance, while TG and HDL-C levels might be good markers of insulin resistance in non-obese patients with type 2 diabetes mellitus in Korea. | 14767863 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Evaluation of the synergistic effect of insulin resistance and insulin-like growth factors on the risk of breast carcinoma. | 14770423 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The results of the current study suggest that insulin resistance and IGFs may synergistically increase the risk of breast carcinoma. | 14770423 |
| methyldopa, Dyslipidemias | Deregulated Nutrient Sensing | There was a highly significant, direct association of indicators of dyslipidemia such as increasing HDL/LDL quotient and decreasing HDL with the severity of AMD. | 14872268 |
| Precocious pubarche, Dyslipidemias, Hyperandrogenism | Deregulated Nutrient Sensing | Premature pubarche, hyper-insulinism, dyslipidemia, and hyperandrogenism, and some combinations of these, can be associated with reduced fetal growth. | 14960029 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was a significant association between increasing severity of ED and the presence of diabetes, hypertension, dyslipidemia, smoking, increased BMI, increased values of EDV, decreased values of PSV, RI and rigidometer (P<0.001 for each). | 14963466 |
| No metabolic abnormalities, Premature coronary artery atherosclerosis | Deregulated Nutrient Sensing | Metabolic abnormalities related to insulin resistance in patients with premature coronary atherosclerosis appear to be important mediators of major plasma oxidative damage. | 14966465 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Validation of capillary glucose measurements to detect glucose intolerance or type 2 diabetes mellitus in the general population. | 14967156 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The effect of glycemic control in type 2 diabetic patients with diabetes-related dyslipidemia. | 14968220 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, diabetic, Atherosclerosis | Deregulated Nutrient Sensing | The glycemic control in type 2 diabetes significantly improves diabetic related dyslipidemia, and would be expected to reduce the risk of atherosclerosis. | 14968220 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. | 14968294 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is thought to be a key predictor for the development of Type 2 diabetes mellitus and cardiovascular disease (CVD), a leading cause of morbidity and premature mortality in Europe. | 14968294 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Development of Type 2 diabetes, dyslipidaemia, obesity, hypertension and cardiovascular events are additional endpoints. | 14968294 |
| Lipolysis, Hypermetabolism, No metabolic abnormalities, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Many endocrinological and metabolic abnormalities are observed, like hypermetabolism, glucose intolerance, increased proteolysis and lipolysis. | 14969155 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Because insulin resistance and high blood leptin levels are associated with breast cancer, losing weight to improve these parameters may reduce the risk of recurrence. | 14981223 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This study tested whether relations between insulin resistance and beta-cell function differ between current smokers, former smokers and non-smokers, and if having diabetes modifies smoking-related effects. | 14984456 |
| diabetic | Deregulated Nutrient Sensing | Insulin resistance was for normoglycaemic persons highest for current smokers, and for diabetic persons lowest for current smokers (P=0.021). | 14984456 |
| Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperglycaemia and insulin resistance are common in severely burned patients, even if they have not previously had diabetes. | 14987787 |
| Hyperglycemia | Deregulated Nutrient Sensing | Recent studies suggest that hyperglycaemia and insulin resistance are harmful and that correcting blood glucose to normal levels with insulin might improve the prognosis significantly. | 14987787 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes. | 14988285 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance and obesity may be the earliest manifestations of IRS in children with a parental history of the syndrome. | 14988301 |
| Coronary Artery Disease, Atherosclerosis | Deregulated Nutrient Sensing | Insulin sensitivity, insulinemia, and coronary artery disease: the Insulin Resistance Atherosclerosis Study. | 14988302 |
| Hypertension, CTCAE, Endothelial dysfunction, cell wall thickening | Deregulated Nutrient Sensing | Close association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension. | 15001196 |
| Hypertensive (finding), Endothelial dysfunction | Deregulated Nutrient Sensing | Endothelial dysfunction and insulin resistance were observed in hypertensive subjects and were associated with carotid wall thickening. | 15001196 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Our findings suggest that endothelial dysfunction and early structural vascular changes were related to insulin resistance. | 15001196 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Adiponectin, an adipocyte-secreted hormone, is closely and inversely associated with insulin resistance and was recently found to be inversely and independently associated with endometrial cancer. | 15001594 |
| Breast Carcinoma, Obesity | Deregulated Nutrient Sensing | Because insulin resistance in the setting of obesity has also been associated with the development of breast cancer, we have hypothesized that decreased adiponectin levels might underlie the association between breast cancer and obesity/insulin resistance. | 15001594 |
| Glucose Metabolism Disorders, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance underlies most glucose disorders in adults and is associated with an increased risk of cardiovascular disease. | 15010644 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Eighty-nine per cent of patients had hypertension, 68% had dyslipidaemia, 32% were diabetic and 38% were previous smokers. | 15012697 |
| Dyslipidemias, Nephrotic Syndrome | Deregulated Nutrient Sensing | The combined dyslipidaemia that accompanies the nephrotic syndrome increases the cardiovascular risk and appears to worsen long-term renal function. | 15012735 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | This study supports the potential role of insulin resistance in the development of poor clinical outcomes in patients with NAFLD. | 15017611 |
| Coronary heart disease | Deregulated Nutrient Sensing | Temperature at birth, coronary heart disease, and insulin resistance: cross sectional analyses of the British women's heart and health study. | 15020510 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Cold outdoor temperature at birth is associated with increased coronary heart disease, insulin resistance, dyslipidaemia, and poor lung function. | 15020510 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | We sought to evaluate the association between insulin resistance (IR), beta-cell dysfunction, and HCV among orthotopic liver transplant (OLT) recipients. | 15021833 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Clinical practice guidelines for managing dyslipidemias in kidney transplant patients: a report from the Managing Dyslipidemias in Chronic Kidney Disease Work Group of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative. | 15027968 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | Evidence from the general population indicates that treatment of dyslipidemias reduces CVD, and evidence in kidney transplant patients suggests that judicious treatment can be safe and effective in improving dyslipidemias. | 15027968 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemias are very common in CKD and in transplant patients. | 15027968 |
| Obesity | Deregulated Nutrient Sensing | Resistin is a recently discovered signal molecule, which could help elucidation of the pathophysiology of the insulin resistance and its correlation with obesity. | 15034607 |
| Insulin resistance syndrome, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The proportions of 15 : 0 and 17 : 0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P<0.0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD. | 15035691 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Pharmacist intervention for dyslipidemia appears to have a greater impact in patients with diabetes. | 15040652 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Even though dietary intervention resulted in reductions in body mass index (21.0+/- 1.2 vs. 20.1 +/- 1.1 kg/m(2), P<0.01), it did not change dyslipidemia present in the offspring of hypertensive individuals. | 15042250 |
| Atherosclerosis, Dyslipidemias, VAD I protocol, Data types - Address, Hypogonadism | Deregulated Nutrient Sensing | Our results indicate that VaD is associated with atherogenic dyslipidemia, in particular, small dense LDL and carotid atherosclerosis, whereas AD is associated with hyposomatomedinemia and hypogonadism rather than atherosclerosis. | 15045695 |
| Lipodystrophy, Hyperglycemia, Dyslipidemias, Steatohepatitis | Deregulated Nutrient Sensing | Leptin, an adipocyte hormone, when replaced in patients with lipodystrophy, improves insulin resistance, hyperglycemia, dyslipidemia, and hepatic steatosis. | 15045701 |
| Atherosclerosis | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study (IRAS) Family Study recruited extended pedigrees of Hispanic descent from San Antonio, TX (SA) and San Luis Valley, CO (SLV). | 15047638 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | These findings highlight the importance of risk factors, such as high blood pressure and dyslipidaemia, in increasing CVD risk in those with diabetes. | 15049931 |
| Atherosclerosis, Dais (plant), Dyslipidemias, diabetic, Coronary Artery Disease | Deregulated Nutrient Sensing | The Diabetes Atherosclerosis Intervention Study (DAIS) examined the effects of fenofibrate or placebo on the progression of coronary artery disease (CAD) in 418 type 2 diabetic subjects with dyslipidemia. | 15050487 |
| Restenosis | Deregulated Nutrient Sensing | Our findings suggest that insulin resistance measured by the homeostasis model assessment predicts restenosis after coronary stent placement in nondiabetic patients. | 15050499 |
| Weight Gain | Deregulated Nutrient Sensing | However, their influence on weight gain, insulin resistance and other cardiovascular risk factors, as well as possible differences in obese and lean subjects, have not been fully evaluated. | 15057672 |
| Weight Gain, Obesity | Deregulated Nutrient Sensing | Weight gain was inversely related to age (beta= - 0.125, R = 0.38, p = 0.046), and insulin resistance was related to obesity at baseline (beta = 0.85, R = 0.46, p = 0.02). | 15057672 |
| Hyperphagia, Obesity, Hypothalamic structure | Deregulated Nutrient Sensing | Similarly, patients with hypothalamic damage may develop central obesity, insulin resistance, and hyperphagia. | 15057893 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | The majority of patients developed elevated glucose levels and dyslipidemia by time of diagnosis of NAFLD. | 15057893 |
| Weight Gain, Dyslipidemias, Pituitary Diseases, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In conclusion, patients with hypothalamic and/or pituitary disease are at risk of excessive weight gain, impaired glucose tolerance, and dyslipidemia with subsequent development of NAFLD. | 15057893 |
| HIV-Associated Lipodystrophy Syndrome, Fatty infiltration | Deregulated Nutrient Sensing | Improvement of fat redistribution, insulin resistance and hepatic fatty infiltration in HIV-associated lipodystrophy syndrome by pioglitazone: a case report. | 15061300 |
| Inflammation, Coronary heart disease | Deregulated Nutrient Sensing | The extinction of those birth cohorts would result in a relative increase in cases coming from a 2nd subpopulation, which was characterized by insulin resistance and chronic expression of low-grade inflammation markers and was comparatively less vulnerable to die acutely from coronary heart disease. | 15061621 |
| Hypertension, CTCAE, Albuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | The results demonstrate on the one hand, very high indices of cardiovascular risk (smoking, hypertension, dyslipidaemia and albuminuria) and on the other, good quality primary health care providing good detection and follow up management of type 2 diabetic patients. | 15063599 |
| Carotid Atherosclerosis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjusting for age, smoking habits, consumption of alcohol, and the presence of diabetes mellitus and dyslipidemia, female subjects with the T allele of T43839A had more severe carotid atherosclerosis compared to individuals with the A allele. | 15064106 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | We used the concentration of plasma C-peptide (an indicator of insulin production) to determine whether insulin and insulin resistance are associated with the risk of developing colorectal cancer. | 15069117 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Elevated insulin production, as reflected by elevated concentrations of plasma C-peptide, may predict the risk of developing colorectal cancer, independently of BMI, factors related to insulin resistance, or levels of IGF-I and IGFBP-3. | 15069117 |
| Rabson-Mendenhall Syndrome | Deregulated Nutrient Sensing | Efficacy of recombinant methionyl human leptin therapy for the extreme insulin resistance of the Rabson-Mendenhall syndrome. | 15070911 |
| HIV-Associated Lipodystrophy Syndrome | Deregulated Nutrient Sensing | Recombinant methionyl human leptin (r-metHuLeptin) therapy has shown clear efficacy in the treatment of severe insulin resistance associated with lipodystrophy syndromes and low leptin levels. | 15070911 |
| Rabson-Mendenhall Syndrome | Deregulated Nutrient Sensing | We treated two siblings with Rabson-Mendenhall syndrome (severe insulin resistance and presumed insulin receptor mutations). | 15070911 |
| Acanthosis Nigricans, Diabetes Mellitus | Deregulated Nutrient Sensing | The brother and sister, aged 13 and 11 yr, respectively, had severe acanthosis nigricans, insulin resistance, and diabetes. | 15070911 |
| Liver damage | Deregulated Nutrient Sensing | (2) Prolonged excessive insulin/IGF signaling accelerates cellular damage in cerebral neurons. | 15082091 |
| Hyperinsulinism, Dyslipidemias, Coronary Arteriosclerosis, Benign prostatic hypertrophy, Diabetes Mellitus, Obesity, Hyperuricemia, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Previous studies have shown that non-insulin-dependent diabetes mellitus (NIDDM), hypertension, atherosclerotic disease manifestations, tallness, obesity, dyslipidaemia, hyperuricaemia, hyperinsulinaemia and high alanine aminotransferase (ALAT) levels are risk factors for development of benign prostatic hyperplasia (BPH). | 15083641 |
| Dyslipidemias, Hyperinsulinism, Prostate carcinoma, Hyperuricemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The results of the present study suggest that the prostate gland volume, the BPH growth rate, hypertension, obesity, dyslipidaemia, hyperuricaemia, hyperinsulinaemia and high ALAT levels are risk factors for the development of clinical prostate cancer. | 15083641 |
| Obesity | Deregulated Nutrient Sensing | Uric acid nephrolithiasis, a condition associated with a low urinary pH, has been linked to obesity and insulin resistance. | 15086484 |
| Obesity | Deregulated Nutrient Sensing | The results confirm the previously proposed scheme that obesity may sometimes cause uric acid nephrolithiasis by producing excessively acid urine due to insulin resistance. | 15086484 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Flutamide suppresses adrenal steroidogenesis but has no effect on insulin resistance and secretion and lipid levels in overweight women with polycystic ovary syndrome. | 15087595 |
| Hypertension, CTCAE, Dysglycemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The MS is defined as the clustering of three or more of the cardiovascular risk factors of dysglycemia, hypertension, dyslipidemia, and obesity. | 15093872 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Fasting insulin levels and insulin resistance increased at baseline in all subjects with diabetes and decreased during OAAM supplementation. | 15094102 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | The SV/PP ratio was related to main components of the insulin resistance syndrome, concentric LVH and a low E/A ratio. | 15097228 |
| HIV Infections | Deregulated Nutrient Sensing | The level of interleukin-18 (IL-18) is elevated in patients with HIV infection as well as in people with insulin resistance (IR). | 15097301 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | There are significant associations of lipid profiles with hemostatic factors, the directions of which suggest novel pathways by which dyslipidemia may contribute to coronary heart disease. | 15099276 |
| diabetic | Deregulated Nutrient Sensing | However, a small subset of these patients develops postoperative insulin resistance regardless of their preoperative diabetic status. | 15103177 |
| Hyperglycemia | Deregulated Nutrient Sensing | Ten patients (3%) had postoperative hyperglycemia (serum glucose > or =250 mg/dl or 13.9 mmol/l) due to insulin resistance. | 15103177 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia was detected in 80%, insulin resistance in 92%. | 15108431 |
| Dyslipidemias | Deregulated Nutrient Sensing | Thus, the P143L polymorphism may play a role in causing decreased HDL-C levels, leading to increased risk of dyslipidemia and CAD in Chinese. | 15110745 |
| Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Orlistat leads to improved glycemic control in obese type 2 diabetic patients, which is attributed to decreased insulin resistance associated with weight loss. | 15111524 |
| Weight decreased, diabetic | Deregulated Nutrient Sensing | The results of this study suggest that apart from decreasing insulin resistance as a result of weight loss, orlistat may increase postprandial GLP-1 levels, thereby enhancing the insulin secretory response to the meal and blunting the postprandial rise in glucose in type 2 diabetic patients. | 15111524 |
| Steatohepatitis | Deregulated Nutrient Sensing | Steatohepatitis may be the only manifestation of insulin resistance and warrants further evaluation. | 15112913 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Veterans with IHD were more likely to have dyslipidemia (81 vs. 53%), were equally likely to be treated (54 vs. 50%), and were more likely to have optimal LDL levels (30 vs. 16%) compared with veterans without IHD, all P values <0.01. | 15113780 |
| Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Comparative analysis was performed between the cases and controls regarding dyslipidemia, BMI, hypertension, diabetes, and ischemic heart disease after age adjustment with logistic regression. | 15114275 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes. | 15114470 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Comparison of effects of exercise and diuretic on left ventricular geometry, mass, and insulin resistance in older hypertensive adults. | 15117727 |
| Increased insulin level | Deregulated Nutrient Sensing | Exercise training reduced glucose-stimulated hyperinsulinemia (before: 13.65 +/- 2.6 vs. 9.84 +/- 1.5 mU.ml(-1).min; P = 0.04) and insulin resistance. | 15117727 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Unlike hydrochlorothiazide, exercise training can improve insulin resistance and aerobic capacity in older hypertensive people. | 15117727 |
| TG gene | Deregulated Nutrient Sensing | Insulin resistance is often associated with increased triglyceride (TG) and decreased HDL-cholesterol (HDL-C) concentrations and increased small LDL particles. | 15117857 |
| AURKAIP1 gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We studied the effect of pioglitazone, a thiazolidinedione that reduces insulin resistance, on the AIP of patients with type 2 diabetes. | 15117857 |
| Non-Functioning Adrenal Cortex Adenoma, Cushing Syndrome, Glucose Intolerance (disease), Obesity, Adrenal Gland Hyperfunction, Hypertension, CTCAE | Deregulated Nutrient Sensing | Improvement of hypercortisolemia even in a moderate case of Cushing's syndrome not only ameliorates hypertension, obesity and glucose intolerance, but also restores the accompanying dysfunctions of anterior pituitary, suggesting the clinical importance of early discovery and treatment of functioning adrenocortical incidentalomas. | 15118271 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance has been proposed as the initial step in the cascade toward type 2 diabetes mellitus. | 15120209 |
| Hyperactive behavior, Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disorders | Deregulated Nutrient Sensing | We hypothesize that neurovascular interactions, in particular arterial elongation, causes compression of the right lateral medulla, triggering a state of autonomic dysfunction including hyperactivity of pancreatic endocrine function, and predisposes to insulin resistance and the development of type 2 diabetes. | 15120209 |
| Hyperandrogenemia, Hyperlipidemia, HIV, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Human immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome. | 15121620 |
| Hypertension, CTCAE, Dyslipidemias, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Frequencies of risk factors among the SLE patients compared to controls were hypertension (30% vs 24%), smoking (23% vs 24%), and dyslipidemia (17.7% vs 17%). | 15124249 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The risk factors found to be most strongly associated with presence of angiographically-detected CAD in the population studied were diabetes mellitus, dyslipidaemia, age and male gender. | 15125091 |
| Microalbuminuria | Deregulated Nutrient Sensing | Accordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance. | 15126010 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We did not consider screening targeted to persons with dyslipidemia, and we used studies of people whose diabetes was detected clinically to estimate screening benefits. | 15126252 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | A transition of T to C at nucleotide position 16189 in the hypervariable D-loop region of mitochondrial DNA (mtDNA) has attracted research interest for its probable correlation with increasing insulin resistance and development of diabetes mellitus (DM) in adult life. | 15126308 |
| Cerebrovascular accident, Pathology, Cardiovascular Diseases | Deregulated Nutrient Sensing | Taken together, we suggest that the mtDNA 16189 variant is a predisposing genetic factor for the development of insulin resistance and may be related to various phenotypic expressions in adult life such as development of DM and vascular pathologies involved in stroke and cardiovascular diseases. | 15126308 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Subclinical hypothyroidism (sHT) is associated with dyslipidemia and enhanced cardiovascular risk. | 15126526 |
| Ketoacidosis, Diabetes Mellitus | Deregulated Nutrient Sensing | The recognition of diabetes mellitus type 2 as the underlying illness in some patients who present with ketoacidosis means that these patients can be specifically treated for their basic problem, which is insulin resistance. | 15129562 |
| Acromegaly, Chronic disease | Deregulated Nutrient Sensing | The aim of the study was to evaluate ApN secretion in patients with acromegaly, a chronic disease associated with insulin resistance and increased cardiovascular mortality, and to correlate ApN levels with hormonal, metabolic and cardiovascular parameters. | 15132722 |
| Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Moreover, concentrations of adiponectin are reduced in individuals with obesity, insulin resistance and cardiovascular disease. | 15132729 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Fasting plasma adiponectin and ghrelin levels were found to be associated with central obesity or insulin resistance. | 15132729 |
| Dyslipidemias, Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | The leading risk factors were obesity, dyslipidemia, and depression. | 15133378 |
| Hyperlipidemia, Dyslipidemias, USF1 wt Allele, Premature coronary artery atherosclerosis | Deregulated Nutrient Sensing | Familial combined hyperlipidemia (FCHL) is the most common familial dyslipidemia, and is implicated in up to 20% of cases of premature coronary heart disease. | 15136067 |
| Pituitary gland enlarged, Obesity | Deregulated Nutrient Sensing | Familial juvenile autoimmune hypothyroidism, pituitary enlargement, obesity, and insulin resistance. | 15142366 |
| deficiency aspects, Autoimmune Thyroid Disease Pathway, Obesity | Deregulated Nutrient Sensing | Because of the unusual association of autoimmune thyroid disease, insulin resistance and obesity rather than insulin deficiency, we searched for possible genetic abnormalities. | 15142366 |
| Autoimmune Thyroid Disease Pathway | Deregulated Nutrient Sensing | The HLA haplotypes did not cosegregate with autoimmune thyroid disease or insulin resistance. | 15142366 |
| Pituitary gland enlarged, Obesity, Hypothyroidism, Autoimmune | Deregulated Nutrient Sensing | In conclusion, the remarkably high incidence of childhood autoimmune hypothyroidism, pituitary enlargement, insulin resistance and obesity in this family is not linked to known HLA types or known gene defects. | 15142366 |
| Weight Gain | Deregulated Nutrient Sensing | Weight gain over time in individuals with relative insulin resistance at baseline, as measured by QUICKI, was the greatest among those who consumed a higher percent of energy from fat. | 15146168 |
| Weight Gain | Deregulated Nutrient Sensing | Further investigation into the relationship between insulin resistance, diet, and weight gain is warranted. | 15146168 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In subjects with type 2 diabetes and impaired glucose tolerance, high coffee consumption (>/=5 cups day(-1)) was inversely associated with insulin resistance. | 15147528 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Most cases are due to the cluster of classical risk factors, such as smoking, diabetes, high blood pressure and dyslipidaemia. | 15147532 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | It has been suggested that dyslipidaemia, an important CHD risk factor, may be worsened by dialysis. | 15149883 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | We speculate that, with repeated dialysis, dyslipidaemia may get progressively worse and further accentuate CHD risk. | 15149883 |
| Glucose Intolerance (disease), Periodontal Diseases | Deregulated Nutrient Sensing | The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study. | 15153457 |
| Hyperinsulinism, Epilepsy | Deregulated Nutrient Sensing | Familial hyperinsulinaemia associated with epilepsy and mental retardation--a syndrome of familial insulin resistance. | 15154952 |
| Autosome, Hyperandrogenism, Genes, Recessive | Deregulated Nutrient Sensing | Variants of type A insulin resistance, characterized by female hyperandrogenism and 'acromegaloid' features, have been ascribed to genetic defects of the insulin receptor or post-receptor pathways via autosomal dominant or recessive inheritance patterns. | 15154952 |
| Epilepsy, Congenital Rubella Syndrome | Deregulated Nutrient Sensing | Whilst a variety of congenital syndromes of insulin resistance are identified by their characteristic clinical phenotypes, an association with epilepsy and mental retardation has not previously been reported. | 15154952 |
| Acanthosis Nigricans, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The eldest has features of severe insulin resistance with dyslipidaemia, acanthosis nigricans, 'acromegaloid features' and diabetes requiring high dose insulin therapy in combination with a glitazone. | 15154952 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The frequency of smoking, hypertension, and dyslipidaemia was similar in the two groups, but plasma homocysteine was higher in patients with PAPS (mean (SD) 11.9 (6.2) v 8.2 (3.4) micromol/l, p = 0.037). | 15155372 |
| Weight Gain | Deregulated Nutrient Sensing | Associations between lower birth weight and insulin resistance may be dependent on rapid weight gain during the early postnatal years. | 15156313 |
| Hypoglycemia, Reactive hypoglycemia | Deregulated Nutrient Sensing | The findings demonstrate the coexistence of severe postprandial hypoglycemia, insulin resistance, and impaired insulin clearance and suggest that hypoglycemia should be considered as a phenotype linked to heterozygote mutations in the insulin receptor gene. | 15161766 |
| Ventricular hypertrophy | Deregulated Nutrient Sensing | Candesartan, an angiotensin II receptor blocker, improves left ventricular hypertrophy and insulin resistance. | 15164328 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | Angiotensin II receptor blockers (ARB) have been reported to regress LVH and improve insulin resistance. | 15164328 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | We tested the hypothesis that candesartan, an ARB, could regress LVH, in association with improvement of insulin resistance in EH patients. | 15164328 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | Our findings suggest that pharmacological blockade of angiotensin II receptors by candesartan could improve LVH in never-treated EH patients, which may relate to the improvement of insulin resistance. | 15164328 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Markers of insulin resistance are often apparent in nondiabetic relatives of subjects with type 2 diabetes. | 15166304 |
| Diabetes Mellitus, Family history, diabetic | Deregulated Nutrient Sensing | Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known. | 15166304 |
| Family history | Deregulated Nutrient Sensing | There was no evidence for a stronger association of FH score with visceral fat accumulation than with subcutaneous fat or insulin resistance. | 15166304 |
| Family history, Diabetes Mellitus | Deregulated Nutrient Sensing | The absence of an association between FH score and insulin resistance/fat accumulation in San Luis Valley is consistent with the idea that the expression of transmitted diabetes genes may be suppressed in leaner, more physically active populations. | 15166304 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A family with severe insulin resistance and diabetes due to a mutation in AKT2. | 15166380 |
| Autosome, Diabetes Mellitus | Deregulated Nutrient Sensing | Here we describe a mutation in the gene encoding the protein kinase AKT2/PKBbeta in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus. | 15166380 |
| Steatohepatitis, Glucose Intolerance (disease), Hepatotoxicity, Breast Carcinoma | Deregulated Nutrient Sensing | Tamoxifen induced hepatotoxicity in breast cancer patients with pre-existing liver steatosis: the role of glucose intolerance. | 15167162 |
| Glucose Intolerance (disease), Hepatotoxicity | Deregulated Nutrient Sensing | Glucose intolerance before the beginning of tamoxifen treatment seems to be a predictor of the hepatotoxicity, unrelated to baseline BMI. | 15167162 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Being born small for gestational age (SGA) is associated with insulin resistance, hypertension and increased cardiovascular morbidity/mortality in adulthood. | 15167451 |
| Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Sympathetic nerve hyperactivity is a well-known risk factor for cardiovascular disease mortality and is proposed to link insulin resistance with hypertension. | 15167451 |
| Hypertension, CTCAE, Depression, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Men with co-morbid medical conditions and risk factors, including cardiovascular disease, hypertension, dyslipidemia,and depression all reported higher prevalence of ED. | 15171225 |
| diabetic | Deregulated Nutrient Sensing | Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients. | 15171689 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Thiazolidinedione therapy in the prevention/delay of type 2 diabetes in patients with impaired glucose tolerance and insulin resistance. | 15171752 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Recent studies suggest that early treatment with TZDs may prevent the progression from insulin resistance (IR) to type 2 diabetes mellitus (T2DM). | 15171752 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, the relationship between dyslipidemia and asymptomatic chronic HBV infection is still unclear. | 15175824 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results suggest that isohumulones can improve insulin sensitivity in high fat diet-fed mice with insulin resistance and in patients with type 2 diabetes. | 15178687 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A polymorphism in the IL-6 gene, a G-to-C substitution 176 bp upstream of the ATG translation initiation site, has been associated with diabetes prevalence and insulin resistance. | 15180970 |
| Hyperlipidemia, Neurosecretory Systems, Obesity | Deregulated Nutrient Sensing | Replacement therapy with recombinant methionyl human leptin (r-metHuLeptin) improves obesity, insulin resistance, hyperlipidemia, and neuroendocrine dysfunction associated with low-leptin states. | 15181040 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance has been implicated as an important initiating factor in coronary atherosclerosis. | 15187569 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | However, associations between insulin resistance and specific morphologic features of atherosclerotic coronary arteries remain unclear. | 15187569 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | We ultrasonographically evaluated the morphologic features of atherosclerotic coronary arteries in nondiabetic patients with insulin resistance. | 15187569 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Twenty Type 2 diabetic patients with dyslipidemia were treated 3 months with simvastatin (20 mg daily) and then 3 months with fenofibrate (200 mg daily) with 2 months of wash-out between the two treatments. | 15189781 |
| Fatty Liver, Hypertensive (finding) | Deregulated Nutrient Sensing | Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance. | 15194655 |
| Fatty Liver, Hypertensive (finding) | Deregulated Nutrient Sensing | The aim of the present study was to test the hypothesis that fatty liver with normal liver enzymes occurs more frequently in arterial hypertensive patients and to establish whether this condition is associated with insulin resistance. | 15194655 |
| Fatty Liver | Deregulated Nutrient Sensing | Stepwise logistic regression and multivariate regression analysis were used on the combined sample to identify variables independently associated with fatty liver and insulin resistance. | 15194655 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Hypertensive patients had a significantly higher prevalence of fatty liver (30.9% v 12.7%; p<0.041), higher insulin resistance (mean 2.27 (SD 1.81) v 1.56 (0.70); p = 0.022), and slightly higher body mass index (24.9 (3.0) v 24.0 (2.2); p = 0.043) than controls. | 15194655 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Multivariate regression analysis showed insulin resistance to be predicted by alanine transaminase (p = 0.002), presence of arterial hypertension (p = 0.029), and body mass index (p = 0.048). | 15194655 |
| Hypertensive (finding), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The higher prevalence of non-alcoholic fatty liver in non-obese hypertensive patients with normal liver enzymes appears to be related to increases in insulin resistance and body weight. | 15194655 |
| Dyslipidemias, Atherosclerosis, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | It thus represents a candidate gene for the risk of dyslipidemia, atherosclerosis, and coronary heart disease (CHD). | 15199365 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | The present study was performed to evaluate the association between the PPARalpha polymorphism L162V and the presence of dyslipidemia and/or atherosclerotic disease in patients with DM-2 in comparison with nondiabetic controls. | 15199365 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | [Study on correlation of insulin resistance with TCM syndrome type and activity of fibrinolytic system in patients with coronary arterial disease]. | 15199623 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | To study the correlation of insulin resistance (IR) with TCM syndrome type and activity of fibrinolytic system in patients with coronary arterial disease (CAD). | 15199623 |
| Glucose Intolerance (disease), Hypertriglyceridemia | Deregulated Nutrient Sensing | A logistic regression analysis identified environmental toxin exposure and hypertriglyceridaemia, but not glucose intolerance or alcohol overuse as significant risk factors that deserve further investigation as possible causes of CIAP. | 15201191 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance did not appear to be an important mediating factor in the association between leg length and CHD. | 15201241 |
| Acute myocardial infarction, Dyslipidemias | Deregulated Nutrient Sensing | [Statins in dyslipidemia associated with acute myocardial infarct]. | 15202301 |
| Endothelial dysfunction, Atherosclerosis | Deregulated Nutrient Sensing | Recently, it was suggested that a "vascular insulin resistance" could explain this association, causing endothelial dysfunction and hence atherosclerosis. | 15204243 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Vascular insulin response is intact in non-diabetic CAD patients in spite of insulin resistance and endothelial dysfunction. | 15204243 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Subjects predisposed to Type 2 diabetes due to a small birth size are strongly protected from glucose intolerance by regular exercise. | 15207998 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Carriers of the Arg allele did not have a higher prevalence of newly detected (OR 0.49, 95% CI 0.24-1.01) or treated (OR 0.71, 0.37-1.35) Type 2 diabetes in the first study, or a higher prevalence of glucose intolerance (OR 1.07, 0.71-1.59) in the second study. | 15209769 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Physical health status is already reduced prior to diabetes diagnosis, perhaps because of obesity or other aspects of the insulin resistance syndrome. | 15209777 |
| Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, Malignant Neoplasms, INTERCURRENT INFECTION | Deregulated Nutrient Sensing | Subjects had no symptoms of intercurrent infection, known diabetes, treated dyslipidaemia, a chronic inflammatory condition, liver disease or malignancy. | 15211367 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The subjects were matched for age, gender, body mass index and the patients with smoking habit, dyslipidaemia, and diabetes mellitus were excluded from the study. | 15215878 |
| Cardiovascular morbidity, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Subjects with type 2 diabetes experience an increased cardiovascular morbidity and mortality, related to a high prevalence of hypertension, dyslipidemia, and obesity. | 15216449 |
| Anxiety, CTCAE 3.0, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Our data suggest that self-reported social anxiety is associated with two established risk factors for cardiovascular disease: dyslipidemia and increased WHR. | 15219655 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. | 15221799 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Mutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown. | 15221799 |
| Arterial Stiffness, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes. | 15223220 |
| Arterial Stiffness, Stiff toe, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Short-term aerobic exercise significantly decreased arterial stiffness in both common carotid and femoral arteries, and the reduction of stiffness was associated with improvement of insulin resistance in type 2 diabetes. | 15223220 |
| Microalbuminuria, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria. | 15223221 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | To evaluate the relationship between insulin resistance and endothelial function in type 2 diabetes patients with or without microalbuminuria and to explore the pathophysiological mechanisms of the increased macrovascular risk in type 2 diabetes mellitus. | 15223221 |
| Microalbuminuria, Grade A1 albuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Endothelial dysfunction | Deregulated Nutrient Sensing | Compared with type 2 diabetes patients with normoalbuminuria, patients with microalbuminuria had more severe insulin resistance, more prominent endothelial dysfunction, and higher plasma FFA, PAI-1, and vWF levels. | 15223221 |
| Cardiac complication, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Therefore we speculate that insulin resistance and endothelial dysfunction may act within the metabolic syndrome to increase the cardiovasular risk in this subset of patients, and improving insulin resistance and endothelial dysfunction may reduce the morbidity and mortality from macrovascular complications in type 2 diabetes patients. | 15223221 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | These findings suggest that both glucose intolerance and hypertension could have independent but not synergistic effects on endothelial function--reflected by albumin loss in urine. | 15224799 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Ethnic and sex differences in the prevalence, treatment, and control of dyslipidemia among hypertensive adults in the GENOA study. | 15226165 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our findings suggest that an alarming 9 of 10 dyslipidemic hypertensive adults have untreated or undertreated dyslipidemia. | 15226165 |
| Gout | Deregulated Nutrient Sensing | [Insulin resistance syndrome in patients with gout and its influence on formation of clinical characteristics of the disease]. | 15230133 |
| Cardiomyopathy, Familial Idiopathic | Deregulated Nutrient Sensing | Insulin resistance in idiopathic dilated cardiomyopathy: a possible etiologic link. | 15234411 |
| Cardiomyopathy, Familial Idiopathic | Deregulated Nutrient Sensing | This study was designed to quantify the prevalence of abnormal glucose tolerance and insulin resistance in patients with idiopathic dilated cardiomyopathy (IDCM). | 15234411 |
| Heart failure, Ischemic cardiomyopathy | Deregulated Nutrient Sensing | Insulin resistance is an independent risk factor for mortality in patients with heart failure (HF) and is a known risk factor for ischemic cardiomyopathy. | 15234411 |
| Dyslipidemias | Deregulated Nutrient Sensing | The mean levels of total cholesterol, triglyceride, LDL-cholesterol, MDA and AuAb-oxLDL were decreased while HDL-cholesterol and TAS were increased significantly after lipid-lowering therapy in patients with dyslipidemia. | 15238825 |
| Nonalcoholic Steatohepatitis, Hypertriglyceridemia, Diabetes Mellitus, Hepatomegaly, Lipodystrophy, Hypoleucinemia | Deregulated Nutrient Sensing | Generalized lipodystrophy is characterized by adipose tissue absence, hypoleptinemia, hypertriglyceridemia, insulin resistance, diabetes, hepatomegaly, and nonalcoholic steatohepatitis. | 15240593 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, coronary artery disease, and dyslipidemia were significantly associated with ET-1 levels. | 15240968 |
| Hyperlipidemia, Hypoadiponectinemia | Deregulated Nutrient Sensing | In addition to aggravation of insulin resistance and hyperlipidemia, some hypoadiponectinemia specific mechanisms may stand behind the association. | 15246202 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Insulin, macronutrient intake, and physical activity: are potential indicators of insulin resistance associated with mortality from breast cancer? | 15247127 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Short-term endurance training after coronary artery bypass grafting improves insulin resistance parameters in patients with hypertension. | 15247957 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | It has been shown that short-term exercise training improves insulin resistance parameters in patients with ischaemic heart disease. | 15247957 |
| Dyslipidemias, Hyperinsulinism, Diabetes Mellitus, Hyperferritinaemia, Overweight | Deregulated Nutrient Sensing | The majority of patients were young overweight or obese males, with dyslipidaemia (20-60%), diabetes (10.5%), hyperinsulinaemia (40%), hyperferritinaemia (35%). | 15248380 |
| Non-alcoholic Fatty Liver Disease, Hyperinsulinism, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The typical Italian patient with non-alcoholic fatty liver disease is a young male, obese, not diabetic, with a variable incidence of dyslipidaemia and hyperinsulinaemia. | 15248380 |
| Obesity | Deregulated Nutrient Sensing | Obesity and high blood pressure: a clinical phenotype for the insulin resistance syndrome in African Americans. | 15249791 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The high prevalence of insulin resistance syndrome in African Americans predisposes this population to higher morbidity and mortality from cardiovascular disease. | 15249791 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of prediabetes (24.4%), diabetes (19.2%), and insulin resistance syndrome (87.2%) were highest in the obese-high BP group (p<0.001). | 15249791 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Effects of simvastain combined with omega-3 fatty acids on high sensitive C-reactive protein, lipidemia, and fibrinolysis in patients with mixed dyslipidemia. | 15250255 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Patients with CHD and CHD risk equivalents with mixed dyslipidemia were treated with 10 or 20 mg simvastatin for 6-12 weeks. | 15250255 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | In CHD and CHD risk equivalent patients with mixed dyslipidemia, dyslipidemia's therapeutic effect using simvastatin and omega-3 fatty acids may result from not only the combination of lipid adjustment, but also enhancement of their own nonlipid influences. | 15250255 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Although insulin resistance plays an important role in the development of diabetes in many ethnic populations, the differences in insulin sensitivity between NGT and IGT and between IGT and DM are small in Japanese patients. | 15254872 |
| diabetic | Deregulated Nutrient Sensing | Japanese type 2 diabetic patients are characterized by a larger decrease in insulin secretion and show less attribution of insulin resistance. | 15254872 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | On the other hand, as glucose intolerance increases, insulin secretion decreases most remarkably both between NGT and IGT and between IGT and DM in Japanese patients. | 15254872 |
| Coronary heart disease | Deregulated Nutrient Sensing | Risk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood. | 15254876 |
| Inflammation, Cardiovascular Diseases | Deregulated Nutrient Sensing | This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation. | 15254876 |
| Tumor necrosis, No metabolic abnormalities, Obesity | Deregulated Nutrient Sensing | Tumor necrosis factor-alpha (TNF-alpha) seems to be increased in obese subjects, suggesting its role as a proinflammatory cytokine to insulin resistance and metabolic abnormalities in obesity. | 15254878 |
| Tumor necrosis, Liver Cirrhosis | Deregulated Nutrient Sensing | Increased serum soluble tumor necrosis factor receptor levels are associated with insulin resistance in liver cirrhosis. | 15254888 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance is present in nearly all patients with liver cirrhosis, but its etiology remains unclear. | 15254888 |
| Tumor necrosis, Obesity | Deregulated Nutrient Sensing | Recent studies have shown that tumor necrosis factor-alpha (TNF-alpha) system is involved in the insulin resistance of human obesity. | 15254888 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | This study explored whether TNF-alpha system activity was associated with insulin resistance in liver cirrhosis. | 15254888 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Our study demonstrated that elevated sTNF-RII levels were associated with insulin resistance in liver cirrhosis. | 15254888 |
| Glucose Intolerance (disease), Beta-cell dysfunction | Deregulated Nutrient Sensing | In conclusion, the primacy of beta-cell dysfunction in the process of developing glucose intolerance was strongly suggested in the Japanese general population. | 15254892 |
| Ketoacidosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Main features of this form of diabetes mellitus are the severe insulin resistance and the absence of ketoacidosis. | 15256772 |
| Hyperlipidemia, Premature coronary artery atherosclerosis, Dyslipidemias, USF1 wt Allele, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). | 15258200 |
| Dyslipidemias | Deregulated Nutrient Sensing | These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. | 15258200 |
| Dyslipidemias | Deregulated Nutrient Sensing | Finnish families ascertained for dyslipidemias thus suggest that 10q11, 2q31, and 20q13.32 harbor loci for HDL-C and TGs. | 15258200 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | High PBF levels were associated with increased risk of cardiovascular disease and insulin resistance. | 15258201 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance in Japanese adolescents with type 2 diabetes mellitus. | 15260081 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It was revealed that insulin resistance is present not only in obese adolescents with type 2 diabetes mellitus, but also in non-obese adolescents with type 2 diabetes mellitus. | 15260081 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atorvastatin improves diabetic dyslipidemia and increases lipoprotein lipase activity in vivo. | 15262189 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A major factor contributing to cardiovascular mortality in type 2 diabetes is dyslipidemia, characterized by low HDL cholesterol and high triglycerides, rather than elevated LDL cholesterol. | 15262189 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our data demonstrate that atorvastatin induces a significant improvement of diabetic dyslipidemia and a significant increase of LPL activity. | 15262189 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Obesity, Hyperandrogenism | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) occurs in around 10% women of reproductive age and is characterised by obesity, hyperandrogenism, insulin resistance and adverse lipid profile. | 15262192 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Elevated CRP levels are related to insulin resistance and the presence of the MetS, especially in women. | 15262834 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Visceral fat in hypertension: influence on insulin resistance and beta-cell function. | 15262911 |
| diabetic | Deregulated Nutrient Sensing | Preferential visceral adipose tissue (VAT) deposition has been associated with the presence of insulin resistance in obese and diabetic subjects. | 15262911 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance might increase the risk of fatty liver in the patients with type 2 diabetes. | 15268806 |
| Dyslipidemias, Toxic effect | Deregulated Nutrient Sensing | Clinicians need to remain cognizant of this potential adverse event and discuss signs and symptoms of muscle toxicity with patients in order improve the benefits-to-risks of treating dyslipidemia with statins. | 15269925 |
| Hyperproinsulinemia | Deregulated Nutrient Sensing | Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men. | 15277437 |
| Cardiovascular system | Deregulated Nutrient Sensing | It is clinically important to find noninvasive markers of insulin resistance and hyperproinsulinemia because they both predict cardiovascular and diabetes risk. | 15277437 |
| Hyperproinsulinemia | Deregulated Nutrient Sensing | Sagittal abdominal diameter (SAD) or "supine abdominal height" is a simple anthropometric measure previously shown to predict mortality in men, but its association with insulin resistance and hyperproinsulinemia is unknown. | 15277437 |
| Sandawe language, Hyperproinsulinemia | Deregulated Nutrient Sensing | In multiple regression analyses, including all anthropometric measures, SAD was the only independent anthropometric predictor of insulin resistance (P < 0.001) and hyperproinsulinemia (P < 0.001). | 15277437 |
| Sandawe language, Hyperproinsulinemia | Deregulated Nutrient Sensing | In obese men, SAD seems to be a better correlate of insulin resistance and hyperproinsulinemia (i.e., cardiovascular risk) than other anthropometric measures. | 15277437 |
| Inflammation, Dyslipidemias, Vascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia, inflammation and oxidative stress are prominent risk factors that potentially cause vascular disease in haemodialysis patients. | 15280524 |
| Dyslipidemias | Deregulated Nutrient Sensing | This randomized crossover study demonstrates a potent effect of high-flux haemodialysis on uraemic dyslipidaemia. | 15280524 |
| Dyslipidemias | Deregulated Nutrient Sensing | Low ACP1 activity/high ADA activity joint genotype was also positively associated with dyslipidemia. | 15281007 |
| Hirsutism | Deregulated Nutrient Sensing | A 65-year-old woman presented with elevated testosterone levels, hirsutism and insulin resistance. | 15283061 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | Unhealthy lifestyles may cause hypoadiponectinemia and insulin resistance followed by insulin resistance syndrome, i.e. | 15283178 |
| Calcification of coronary artery, SLC25A20 gene | Deregulated Nutrient Sensing | We examined the association of insulin resistance and MetSyn with coronary artery calcification (CAC) in 840 asymptomatic nondiabetic subjects. | 15289378 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | These findings support the use of biomarkers of insulin resistance in addition to NCEP MetSyn criteria in assessing cardiovascular disease risk. | 15289378 |
| Coma (genus), Glucose Intolerance (disease), Diabetic Ketoacidosis | Deregulated Nutrient Sensing | The severity of cases ranged from mild glucose intolerance to diabetic ketoacidosis or hyperosmolar coma. | 15291665 |
| Obesity | Deregulated Nutrient Sensing | Adiponectin is decreased in obesity and seems to be involved in insulin resistance. | 15292306 |
| Weight decreased | Deregulated Nutrient Sensing | The significant weight loss in 16 children was associated with a significant increase in adiponectin (P = 0.010) and a decrease in insulin resistance (P = 0.013), whereas there were no changes in the 26 children without significant weight loss. | 15292306 |
| Weight decreased | Deregulated Nutrient Sensing | Significant weight loss led to an increase in adiponectin levels and an improvement of insulin resistance. | 15292306 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | We conclude that, in this population of elderly, diabetic patients undergoing rehabilitation, dietary supplementation with chromium is beneficial in moderating glucose intolerance. | 15296075 |
| Dyslipidemias | Deregulated Nutrient Sensing | Except for cigarette smoking and slight dyslipidaemia, classical risk factors for stroke/embolism were absent. | 15297005 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. | 15298351 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim of this study was to measure the heritability estimates for metabolic traits and the features of the insulin resistance syndrome in families with an increased genetic susceptibility to Type 2 diabetes. | 15298351 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In families with a high risk of Type 2 diabetes, the heritability estimates for fasting glucose, pancreatic beta cell function and the features of the insulin resistance syndrome were all high. | 15298351 |
| Arterial Stiffness | Deregulated Nutrient Sensing | The observed increasing arterial stiffness (or decreased elasticity) with increasing number of risk factors related to insulin resistance syndrome in free-living, asymptomatic young adults has important implications for prevention. | 15306189 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Application of YYHT principle in treating patients with diabetes mellitus type 2 of secondary failure to sulfonylurea agents could alleviate the peripheral resistance to insulin, inhibit TNF-alpha, and protect the vascular endothelial cells. | 15307693 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | [Preliminary exploration on effect of qilian decoction in intervention treatment of diabetes mellitus type 2 with insulin resistance and its influence on related inflammatory cytokines]. | 15307695 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum CRP concentrations and factors related to insulin resistance were determined in middle-aged Finnish men who participated in a population-based cohort study and were free of diabetes at baseline. | 15309290 |
| Inflammation, Metabolic Syndrome X, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Low-grade inflammation may increase the risk of the metabolic syndrome and diabetes in middle-aged men, but some of the risk is mediated through obesity and factors related to insulin resistance. | 15309290 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin regulates glucose homeostasis by binding and activating the insulin receptor, and defects in insulin responses (insulin resistance) induce type 2 diabetes. | 15314154 |
| Increased insulin level, Glucose Intolerance (disease), Hyperglycemia | Deregulated Nutrient Sensing | Consequently, SH2-B-/- knockout mice developed age-dependent hyperinsulinemia, hyperglycemia, and glucose intolerance. | 15314154 |
| Glucose Intolerance (disease), Hypertriglyceridemia, Obesity, Fatty Liver Disease | Deregulated Nutrient Sensing | This study confirmed the contribution of obesity, glucose intolerance, and hypertriglyceridemia to NASH development in the Japanese population. | 15318095 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer. | 15322863 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | To study the frequency of insulin resistance (IR) in endometrial cancer patients, its relation to the clinical course of the disease and DNA damage, and to evaluate possible approaches to the pharmacological correction of IR in the patients studied. | 15322863 |
| Malignant neoplasm of endometrium, Neoplasms | Deregulated Nutrient Sensing | The signs of insulin resistance syndrome and its association with the clinical and pathological features of the disease and DNA damage in somatic cells (micronucleus frequency in peripheral blood lymphocytes) and endometrial normal and tumor tissue (alkaline unwinding) were determined in 99 endometrial cancer patients. | 15322863 |
| Increased insulin level | Deregulated Nutrient Sensing | On the other hand, hyperinsulinemia and other hormonal-metabolic disturbances typical of insulin resistance syndrome do not increase the probability of DNA damage of somatic cells (according to the data of micronucleus test). | 15322863 |
| Neoplasms | Deregulated Nutrient Sensing | Thus, insulin resistance/hyperinsulinemia is associated with a more aggressive course of the disease in certain groups of the patients but--in contrast to excessive estrogenic stimulation--does not result in increased genotoxic damage in tumor and normal tissues. | 15322863 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of the cardiovascular disease risk factors, dyslipidemia, hypertension, and diabetes mellitus, is increased in the setting of obesity. | 15328940 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The incidence rates of dyslipidemia, hypertension, and diabetes mellitus do not increase with a greater degree of obesity above a body mass index of 34.99 kg/m2. | 15328940 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | None of the traditional cardiovascular risk factors (hypertension, diabetes mellitus, dyslipidaemia, significant family history, smoking, male gender and increased age) was predictive. | 15329749 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Concomitant diabetes mellitus was present in 31%, hypertension in 58% and dyslipidaemia in 63% of patients. | 15329751 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The majority of patients were males in their sixth decade with underlying dyslipidaemia or hypertension. | 15329751 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Leptin and dyslipidemia are risk factors for cardiovascular disease. | 15331885 |
| Cardiac complication, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia may be a risk factor for cardiovascular complications in marasmic children in the future. | 15331885 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Circulating adiponecin levels are reduced in states of insulin resistance such as type 2 diabetes. | 15333487 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia. | 15333967 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients. | 15335180 |
| Dyslipidemias, Albuminuria | Deregulated Nutrient Sensing | Albuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p<0.01). | 15338128 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM). | 15338456 |
| Cushing Syndrome, Depressed mood | Deregulated Nutrient Sensing | Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment. | 15349009 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus. | 15349727 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, estimated by homeostasis model assessment, and Type 2 diabetes were diagnosed in 803 and 635 patients respectively. | 15349727 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Univariate analysis revealed that plasma MCP-1 levels were significantly and positively correlated with WHR ( p=0.011), insulin resistance ( p=0.0097) and diabetes ( p<0.0001). | 15349727 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In multivariate analysis, the G allele retained statistical significance as a negative predictor of insulin resistance (OR=0.78, 95% CI: 0.65-0.93, p=0.0060) and diabetes (OR=0.80, 95% CI: 0.66-0.96, p=0.018). | 15349727 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In a large cohort of Caucasians, the MCP-1 G-2518 gene variant was significantly and negatively correlated with plasma MCP-1 levels and the prevalence of insulin resistance and Type 2 diabetes. | 15349727 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | In addition, many antipsychotic drugs have been associated with weight gain and some with dyslipidaemia. | 15352932 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | When directly measured, the actual prevalence of obesity was above population norms and two-thirds of patients had a dyslipidaemia. | 15352932 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity, dyslipidaemias and smoking in an inpatient population treated with antipsychotic drugs. | 15352932 |
| Sleep-Disordered Breathing, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Clinic-based studies suggest that sleep-disordered breathing (SDB) is associated with glucose intolerance and insulin resistance. | 15353412 |
| Sleep-Disordered Breathing, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus. | 15353412 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Sleep-related hypoxemia was also associated with glucose intolerance independently of age, gender, body mass index, and waist circumference. | 15353412 |
| Overweight | Deregulated Nutrient Sensing | Prenatal growth restriction is associated with insulin resistance but relatively increased adiponectin concentrations, provided overweight does not ensue. | 15355450 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The contributions of circulating adiponectin to the increased risks for developing insulin resistance and type-2 diabetes in formerly SGA subjects merit further studies. | 15355450 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined the effect of pioglitazone (PIO) on circulating adipocytokine levels to elucidate the mechanisms by which thiazolidinediones improve insulin resistance in type 2 diabetes mellitus (T2DM). | 15356026 |
| Retinal Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and proliferative retinopathy: a cross-sectional, case-control study in 115 patients with type 2 diabetes. | 15356034 |
| Diabetic Retinopathy, PDR gene | Deregulated Nutrient Sensing | In this cross-sectional, case-control study we explored the association of proliferative diabetic retinopathy (PDR) with insulin resistance (IR) in type 2 diabetics with serum creatinine less than 2.0 mg/dl. | 15356034 |
| Obesity | Deregulated Nutrient Sensing | Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. | 15356040 |
| Obesity | Deregulated Nutrient Sensing | Overexpression of 11beta-HSD-1 in murine adipose tissue results in glucocorticoid receptor (GR)alpha overexpression, central obesity, and insulin resistance. | 15356040 |
| Obesity | Deregulated Nutrient Sensing | In conclusion, expression of 11beta-HSD-1 in sc adipose tissue is increased in human acquired obesity and is closely related to accumulation of sc and intraabdominal fat and features of insulin resistance. | 15356040 |
| Obesity | Deregulated Nutrient Sensing | Glucocorticoids play an important role in the pathogenesis of obesity and insulin resistance. | 15356090 |
| Failure (biologic function), Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Failure to down-regulate 11beta-HSD1 activity in patients with diabetes may potentiate dyslipidemia, insulin resistance, and obesity. | 15356090 |
| Increased insulin level, insulinoma | Deregulated Nutrient Sensing | We followed a case of insulinoma that caused primary hyperinsulinemia, and measured the change in visceral fat and insulin resistance before and after surgical resection of the insulinoma. | 15356380 |
| Increased insulin level | Deregulated Nutrient Sensing | These results suggest that hyperinsulinemia might be one of the factors that enhance visceral adiposity and insulin resistance. | 15356380 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Prevalence of hypertension, low HDL-cholesterol, high triglycerides and insulin resistance and the prevalence of most disease outcomes increased with increasing degrees of overweight/obesity. | 15356666 |
| Poor fine motor coordination, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Over 60% of the prevalence of high insulin resistance was attributable to overweight and obesity as was over a third of diabetes and hypertension, a quarter of locomotor disability and a fifth of major CVD. | 15356666 |
| Microvascular Angina, Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest that microvascular disease in the retina may result from processes distinct from dyslipidaemia. | 15359242 |
| Hypertension, CTCAE, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Our findings suggest that subclinical hypothyroidism in middle-aged women is associated with hypertension and dyslipidemia. | 15361814 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Annex: Prevalence of insulin resistance and its association with type 2 diabetes and other cardiovascular risk factors]. | 15362265 |
| Diabetes Mellitus, Arteriopathic disease | Deregulated Nutrient Sensing | We present the results of an epidemiological research undertaken in the province of Cordoba (Argentina) with the aim of studying insulin-resistance (IR) in relation to the increased risk for diabetes and its association with risk factors of arterial disease (RFAD). | 15362265 |
| Hypertensive (finding), Endothelial dysfunction, Ventricular hypertrophy | Deregulated Nutrient Sensing | Plasma ADMA appears to play a major role in endothelial dysfunction in hypertensive patients, independent of insulin resistance or left ventricular hypertrophy. | 15363823 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Effect of amlodipine-atorvastatin combination on fibrinolysis in hypertensive hypercholesterolemic patients with insulin resistance. | 15363826 |
| Hypertensive (finding), Dyslipidemias, Low-Density Lipoproteins | Deregulated Nutrient Sensing | Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. | 15363830 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | In women, LDL particle size may mediate some of the atherogenic effects of low-HDL cholesterol-high-triglyceride dyslipidemia, but does not appear to be independently associated with the extent of coronary atherosclerosis in either sex. | 15363830 |
| Hypertriglyceridemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidaemia in obesity is characterized by hypertriglyceridaemia, low HDL-C levels, small, dense HDL particles and increased phospholipid transfer protein (PLTP) activity. | 15365582 |
| Weight decreased, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Our results suggest that dyslipidaemia in obesity is--at least partially--reversible by weight loss. | 15365582 |
| Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease. | 15365613 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In men with diabetes, increased insulin resistance (homeostasis model assessment, HOMA) was associated with increased levels of haemostatic markers and dyslipidaemia. | 15365613 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Increased insulin resistance among men with Type 2 diabetes is associated with increased prevalence of CHD and of activated haemostasis and dyslipidaemia. | 15365613 |
| Thrombosis, Diabetes Mellitus, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Reducing insulin resistance in men with diabetes may reduce their tendency to develop thrombosis and hence CHD risk. | 15365613 |
| Obesity | Deregulated Nutrient Sensing | The relative effects of obesity and insulin resistance on cardiovascular risk factors in nondiabetic and normotensive men. | 15366636 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The presence of insulin resistance was found to accentuate the risk factors for CHD, with the exception of LDL-C and Apo A-I in the obese. | 15366636 |
| Coronary Restenosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Comparison of frequency of insulin resistance after coronary stenting in patients with type 2 diabetes mellitus with versus without coronary restenosis. | 15374787 |
| Restenosis, diabetic | Deregulated Nutrient Sensing | The large incidence of restenosis after coronary angioplasty in diabetic patients renders this procedure less effective than in nondiabetics, and insulin resistance could be a relevant cause of restenosis in such patients. | 15374787 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disorders | Deregulated Nutrient Sensing | Microalbuminuria, cardiovascular autonomic dysfunction, and insulin resistance in patients with type 2 diabetes mellitus. | 15375795 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disorders | Deregulated Nutrient Sensing | We tested the hypothesis that the presence of microalbuminuria would correlate with cardiovascular autonomic dysfunction and insulin resistance in type 2 diabetic patients. | 15375795 |
| Dyslipidemias | Deregulated Nutrient Sensing | The effect of statins and fibrates on interferon-gamma and interleukin-2 release in patients with primary type II dyslipidemia. | 15380456 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Oxidative stress and antioxidant status in elderly diabetes mellitus and glucose intolerance patients. | 15381345 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | The levels of fasting triglyceride and insulin, as well as insulin resistance index (IRI), were higher in the LVH group than in the control group. | 15447860 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Circulating C-peptide concentrations are associated with insulin resistance and the development of type 2 diabetes. | 15447918 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Furthermore, our study suggests that these nutrients play divergent roles in the development of insulin resistance and type 2 diabetes. | 15447918 |
| Injury of liver, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study. | 15448093 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Our objective was to investigate the associations of elevated AST and ALT with incident type 2 diabetes among 906 participants in the Insulin Resistance Atherosclerosis Study who were nondiabetic at baseline. | 15448093 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Among coronary risk factors, 63% had hypertension, 27% had diabetes, 52% had dyslipidemia, 31% smoked and 21% had a family history of atherosclerosis. | 15449548 |
| beta Thalassemia | Deregulated Nutrient Sensing | Abnormal glucose tolerance is common in multiply transfused beta-thalassemia major patients, which could be attributed to progressive and early loss of beta-cell mass, along with persistent insulin resistance. | 15450007 |
| Executive dysfunction | Deregulated Nutrient Sensing | Insulin resistance and executive dysfunction in older persons. | 15450050 |
| Presenile dementia, Demographics Domain, Executive dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | To evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia. | 15450050 |
| Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The frequency of diabetes, hypertension, dyslipidemia, previous myocardial infarction were common, yet not different between groups (P=NS). | 15450555 |
| Obesity | Deregulated Nutrient Sensing | Adiponectin and resistin, two recently discovered adipocyte-secreted hormones, may link obesity with insulin resistance and/or metabolic and cardiovascular risk factors. | 15451915 |
| Rheumatoid Arthritis, Spondylitis | Deregulated Nutrient Sensing | Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis. | 15458960 |
| Tumor necrosis | Deregulated Nutrient Sensing | Tumour necrosis factor alpha (TNFalpha) may be an important mediator of insulin resistance. | 15458960 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is independently associated with postprandial alterations of triglyceride-rich lipoproteins in type 2 diabetes mellitus. | 15458975 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To evaluate the role of insulin resistance in development of postprandial dyslipidemia in type 2 diabetic patients in an experimental setting in which these patients were compared with nondiabetic subjects at similar glucose and insulin blood levels. | 15458975 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia | Deregulated Nutrient Sensing | Insulin resistance is also associated with postprandial lipoprotein abnormalities in type 2 diabetes after acute correction for hyperglycemia and hyperinsulinemia. | 15458975 |
| Inflammation | Deregulated Nutrient Sensing | The cluster of MS components based on insulin resistance may cause low-grade inflammation. | 15459460 |
| Communicable Diseases, Hyperglycemia | Deregulated Nutrient Sensing | To evaluate whether hyperglycaemia in the first 48 h after infrainguinal vascular surgery is a risk factor for post-operative infection, independent from factors associated with insulin resistance and surgical stress. | 15465374 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Impact of an exercise program on arterial stiffness and insulin resistance in hemodialysis patients. | 15466276 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Arterial stiffness and insulin resistance are independent risk factors for cardiovascular mortality in this population. | 15466276 |
| Glucose Intolerance (disease), Overweight, diabetic | Deregulated Nutrient Sensing | Exercise reduces insulin resistance and glucose intolerance in sedentary, overweight individuals and diabetic patients. | 15466276 |
| Arterial Stiffness | Deregulated Nutrient Sensing | The purpose of this study was to determine the impact of an exercise program on arterial stiffness and insulin resistance in a group of patients on hemodialysis. | 15466276 |
| Arterial Stiffness | Deregulated Nutrient Sensing | The effect of exercise training on arterial stiffness and insulin resistance in 11 patients who were on chronic hemodialysis was evaluated. | 15466276 |
| Arterial Stiffness | Deregulated Nutrient Sensing | These findings suggest that 3 mo of aerobic exercise training improves arterial stiffness, an independent risk factor for cardiovascular mortality in patients who are on hemodialysis, and has no impact on insulin resistance. | 15466276 |
| Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Both Mg deficit and obesity may independently lead to a higher risk for insulin resistance and cardiovascular disease. | 15466953 |
| Glucose Intolerance (disease), Duodenal Somatostatin-Producing Neuroendocrine Tumor | Deregulated Nutrient Sensing | Large duodenal somatostatinoma in the third portion associated with severe glucose intolerance. | 15468970 |
| Inflammation, HIV Infections, Hypertriglyceridemia, Dyslipidemias, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Although it is likely that the greatest proportion of CHD risk in the HIV+ subjects may be accounted for by pathological conditions linked to HIV infection in interaction with mediating processes such as inflammation, central obesity, and dyslipidemia, which was greater than in controls, it appears that PI medications may exacerbate oxidative stress and hypertriglyceridemia to enhance this risk. | 15470277 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes as well as glucose intolerance was greater in men and in the regions of the Center and South of Italy. | 15471153 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was the most common risk factor detected in all patients, followed by smoking (83.3%), dyslipidemia (83.3%) and diabetes (33.3%). | 15471296 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | We conclude that antioxidative activity of small, dense HDL subfractions of altered chemical composition is impaired in MetS and associated with elevated oxidative stress and insulin resistance. | 15472192 |
| Hyperglycemia, Hyperlipidemia | Deregulated Nutrient Sensing | It has been proposed that the hexosamine pathway acts as a nutrient-sensing pathway, protecting the cell against abundant fuel supply, and that accumulation of hexosamines represents a biochemical mechanism by which hyperglycemia and hyperlipidemia induce insulin resistance. | 15472217 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We hypothesized that if an increased flux through the hexosamine pathway caused insulin resistance in humans, the hexosamine levels should be increased in adipose and/or muscle tissue in insulin-resistant subjects, such as patients with type 2 diabetes and obese individuals. | 15472217 |
| Lipodystrophy, Dyslipidemias, Hearing problem | Deregulated Nutrient Sensing | Reasons for switching were treatment simplification (45%), lipodystrophy (24%), renal problems (23%), and dyslipidemia (8%). | 15472856 |
| Heart Diseases, Dyslipidemias, Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | Lower frequencies have been presented for cardiac diseases (27.0%), Diabetes Mellitus (19.9%), and dyslipidemia (15.6%) as risk factors for ischemic stroke in old people of both genders and all ages after 60. | 15476081 |
| Thrombosis, Dyslipidemias, Behcet Syndrome, Thrombophilia | Deregulated Nutrient Sensing | To determine the prevalence of the most common thrombophilias and dyslipidaemia in patients with Behcet's disease with and without thrombosis. | 15479893 |
| Thrombosis, Dyslipidemias, Behcet Syndrome | Deregulated Nutrient Sensing | Blood samples from 107 patients with Behcet's disease who had or did not have thrombosis were analysed for factor V Leiden, prothrombin G20210A polymorphism, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, factor VIII level, homocysteine and C reactive protein concentrations, dyslipidaemia, and plasma glucosylceramide. | 15479893 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | However, dyslipidaemia, predominantly hypertriglyceridaemia, might be a risk factor. | 15479893 |
| Inflammation | Deregulated Nutrient Sensing | An inflammation score is better associated with basal than stimulated surrogate indexes of insulin resistance. | 15486052 |
| Kaposi Sarcoma, Dyslipidemias, Malignant Neoplasms | Deregulated Nutrient Sensing | Seventy-seven percent of the patients smoked cigarettes, 57% had dyslipidemia, and 43% had a malignancy (most commonly Kaposi sarcoma). | 15486847 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Results were then compared to those of 30 control subjects and 16 unrelated patients with primary hypercholesterolemia (Type IIA dyslipidemia) before and after atorvastatin therapy. | 15488884 |
| Schizophrenia | Deregulated Nutrient Sensing | Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients. | 15491236 |
| Inflammation, Thrombosis | Deregulated Nutrient Sensing | In conclusion, apoB is more closely associated with central adiposity, insulin resistance, thrombosis, and inflammation than NHDLC. | 15492304 |
| Hyperandrogenemia, Prostate Cancer Outcomes Study, Endocrine System Diseases, Obesity, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is a common endocrinopathy with symptoms such as obesity, insulin resistance and hyperandrogenemia. | 15497495 |
| Hypertension, CTCAE, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are risk factors for atherosclerosis and occur together more often than expected by chance. | 15498972 |
| Toxic effect | Deregulated Nutrient Sensing | A deleterious consequence of increased mitochondrial efficiency would be a reduced utilization of energy substrates, especially fatty acids, leading to intracellular triglyceride accumulation and lipotoxicity, thus contributing to the onset of skeletal muscle insulin resistance. | 15504966 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In the United States, obesity is a major clinical and public health problem causing diabetes, dyslipidemia, and hypertension, as well as increasing cardiovascular and total mortality. | 15505128 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Multiple logistic regression analysis showed that sex, waist circumference, triglyceride level, and insulin resistance were independently associated with NAFLD in the normal-weight group. | 15505132 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Effects of changes in body weight and insulin resistance on inflammation and endothelial function in morbid obesity after bariatric surgery. | 15507518 |
| Inflammation, Endothelial dysfunction, Obesity | Deregulated Nutrient Sensing | Metabolic alterations such as insulin resistance are thought to underlie the endothelial dysfunction and low grade inflammation found in morbid obesity. | 15507518 |
| Inflammation, Glucose Intolerance (disease), Acute myocardial infarction, Diabetes Mellitus | Deregulated Nutrient Sensing | Inflammation, insulin resistance, and glucose intolerance in acute myocardial infarction patients without a previous diagnosis of diabetes mellitus. | 15509644 |
| Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | The diabetes was associated with overweight, overage and higher insulin, HbA1C and insulin resistance levels. | 15511355 |
| Metabolic Syndrome X, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD) is considered to be the liver component of the metabolic syndrome and is frequently associated with obesity, dyslipidemia and type II diabetes mellitus (NIDDM). | 15513385 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia, with elevated triglycerides and/or hypercholesterolemia, was now present in 65 patients (81%). | 15513385 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We therefore hypothesized that an impaired meal-related vascular response might be an in vivo marker of vascular insulin resistance, related to the presence of diabetes and/or higher age. | 15513964 |
| diabetic | Deregulated Nutrient Sensing | Therefore, meal ingestion results in impaired vasodilator responses in older nondiabetic and diabetic adults, related to aging rather than insulin resistance. | 15513964 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The results suggest that hyperinsulinemia/insulin resistance may be responsible for low progesterone levels during the luteal phase in PCOS. | 15517078 |
| Acromegaly, Atherosclerosis, Somatotropin deficiency | Deregulated Nutrient Sensing | Atherosclerosis and insulin resistance are common complications of adult growth hormone deficiency (GHD) and acromegaly. | 15519253 |
| Acromegaly, Somatotropin deficiency | Deregulated Nutrient Sensing | Adiponectin levels are similar in patients with GHD and healthy controls, whereas in patients with acromegaly, insulin resistance appears to be not closely related to adiponectin levels compared with BMI. | 15519253 |
| Acromegaly, Somatotropin deficiency | Deregulated Nutrient Sensing | The different relationship between adiponectin and QUICKI observed in the adult GHD and acromegaly groups presumably reflects differences in the mechanisms of insulin resistance under states of GH deficiency or excess. | 15519253 |
| Atherosclerosis | Deregulated Nutrient Sensing | We measured F2-isoPM in urine of 52 participants of the Insulin Resistance Atherosclerosis Study by both methods. | 15519902 |
| Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Nearly half of the study sample (46%) was aware of the fact that a healthy lifestyle may contribute to stroke prevention, but only 24% mentioned that medical follow-up and control of hypertension, dyslipidemia and diabetes mellitus reduce the risk of stroke. | 15521679 |
| Obesity | Deregulated Nutrient Sensing | Resistin, a peptide hormone, has been discussed controversially as a missing link between obesity and insulin resistance. | 15523596 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Patients with end-stage renal disease (ESRD) are known to have insulin resistance. | 15523598 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | It is considered that the determination of apolipoproteins may be useful not only for the detection of risk factors for atherosclerosis, but also for a better insight concerning the mechanisms involved in the development of an atherogenic dyslipidemia. | 15523947 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia, elevated LDL cholesterol and reduced nocturnal blood pressure dipping denote lacunar strokes occurring during nighttime. | 15525295 |
| Dyslipidemias | Deregulated Nutrient Sensing | The mean low-density lipoprotein (LDL) cholesterol level was significantly higher amongst patients with nocturnal strokes (133.3 +/- 35.2 mg/dl vs. 115.5 +/- 39.8 mg/dl; P = 0.04), as well as the proportion of patients with any dyslipidemia (94% vs. 77.8%; P = 0.047). | 15525295 |
| Dyslipidemias, Stroke, Lacunar | Deregulated Nutrient Sensing | Dyslipidemia, especially elevated LDL cholesterol is more prevalent in nocturnal lacunar strokes especially when combined with a reduced nocturnal dipping of blood pressure. | 15525295 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | A study of 48 patients with angina pectoris carried out, in which the structural lipids of the hair were analyzed and correlated with the manifestations of angina and the potential incidence of dyslipidemia. | 15526542 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | The analysis of the hair has been shown to be also useful in detecting latent dyslipidemia associated with angina pectoris. | 15526542 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | Also, through the analysis of hair, large scale epidemiologic studies can be carried out on the association between dyslipidemia and angina pectoris. | 15526542 |
| Cerebrovascular Disorders, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | Earlier studies have shown that the fatty acid binding protein 2 (FABP2) T54 allele is associated with dyslipidemia, which in turn correlates with the incidence of cerebrovascular disease (CVD). | 15527447 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | Oral anti-diabetic combinations that address insulin resistance and beta-cell dysfunction (e.g. | 15529514 |
| Autoimmune Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Two of the three insulin resistant children had positive GADA and one of them had positive ICA, therefore showing "mixed" features of both type 1 (autoimmunity) and type 2 diabetes (insulin resistance). | 15529623 |
| Coronary Artery Disease, Turner Syndrome | Deregulated Nutrient Sensing | In addition, insulin resistance may be present in up to 50% of women with Turner syndrome and an atherogenic lipid profile (increased cholesterol, triglycerides) favors the development of coronary artery disease. | 15529627 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, NEUROD1 wt Allele | Deregulated Nutrient Sensing | NIDDM: new once-daily intervention for type 2 diabetes mellitus: Diaprel MR. Pharmacological treatment of hyperglycemia should address to both abnormalities in T2DM treatment, that is reduction of insulin resistance and restoration of normal insulin secretion. | 15529633 |
| Hirsutism, Hypertriglyceridemia | Deregulated Nutrient Sensing | The severity of hypertriglyceridemia and hirsutism in females was related to that of insulin resistance. | 15531479 |
| Hyperglycemia | Deregulated Nutrient Sensing | Critical illness is associated with insulin resistance and hyperglycemia. | 15531485 |
| Hypoadiponectinemia, Acromegaly | Deregulated Nutrient Sensing | We hypothesized that hypoadiponectinemia was present in acromegaly, as in other conditions with increased insulin resistance and cardiovascular risk. | 15531496 |
| Hypoadiponectinemia, Acromegaly | Deregulated Nutrient Sensing | Hypoadiponectinemia, reversible with GH-lowering therapies, may contribute to the increased insulin resistance and cardiovascular risk in patients with acromegaly. | 15531496 |
| Obesity | Deregulated Nutrient Sensing | Adiponectin, a novel adipocytokine with insulin sensitizing properties, is inversely related to obesity and insulin resistance in adults. | 15531504 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Both the point at which sensitivity equaled specificity and the shortest distance in the receiver operating characteristic curves for hypertension, dyslipidemia, diabetes, or >/=2 of these risk factors suggested a BMI cutoff of 24 and a waist circumference cutoff of 80 cm for both men and women. | 15531658 |
| Burn Specimen Source Codes | Deregulated Nutrient Sensing | This decrease may be the result of marked insulin resistance, as suggested by the elevated insulin to glucose ratio in burn patients. | 15534457 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | These subjects fell into three distinct lipid patterns: atherogenic dyslipidemia, isolated hypercholesterolemia, and mixed dyslipidemia. | 15539961 |
| Menstrual abnormalities, Arthralgia, Diabetes Mellitus, Glucose Intolerance (disease), Headache, Erectile dysfunction, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients were reviewed for the presence of headaches, arthralgias, hypertension, menstrual abnormalities, impotence, glucose intolerance or diabetes. | 15542931 |
| Obesity, diabetic | Deregulated Nutrient Sensing | Since obesity affects insulin resistance, the diabetic patients were also divided into two groups: those with a BMI of <23, and those with a BMI of >23. | 15543562 |
| Dyslipidemias | Deregulated Nutrient Sensing | Of the vascular risk factors, both the smoking (7.5 +/-4.7 ng/mL) and dyslipidemia groups (7.4+/-4.4 ng/mL) showed significantly increased plasma TGF-beta1 levels, compared to the non-smokers (5.5+/-2.8 ng/mL), and those without dyslipidemia (4.8+/-2.8 ng/mL) (P<0.05). | 15546028 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Debate surrounds the relative importance of impaired beta-cell secretory function versus insulin resistance in type 2 diabetes. | 15551159 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Non-HDL cholesterol is now recommended as an index of risk associated with combined dyslipidemia, and it has also been found useful in predicting coronary heart disease (CHD) risk in patients with diabetes. | 15552218 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | ), therapy of dyslipidemias, antihypertensive therapy and diabetes control. | 15552230 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia in patients with angiographically confirmed coronary artery disease--an opportunity for improvement. | 15553311 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | Our data suggest that hepatic steatosis can increase insulin resistance independently of obesity. | 15553597 |
| Demographics Domain, Hypercholesterolemia, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalences of diabetes mellitus (DM) (24.7%, 33.6%, 41.1% and 44.7%, respectively) and impaired glucose tolerance (IGT) (5.9%, 8.0%, 9.3% and 11.0%, respectively) steadily increased, whereas dyslipidemia (high total cholesterolemia, high triglyceridemia, or low high-density lipoproteinemia) and hypertension remained unchanged. | 15557709 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | In 1993, DM and dyslipidemia were significant predictors for MVD (Odds Ratio: 2.72 and 2.68, respectively). | 15557709 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, fenofibrate effectively improves atherogenic dyslipidemia by reducing remnants and small LDL, as well as by increasing HDL particles. | 15557710 |
| Diastole | Deregulated Nutrient Sensing | Insulin resistance (P = .01), serum triglycerides (P = .01), C-reactive protein (P = .03), and blood pressure (P = .07 for both systolic and diastolic) improved more with the low-glycemic load diet. | 15562127 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These results show an inverse association between vitamin D status and diabetes, possibly involving insulin resistance, in non-Hispanic whites and Mexican Americans. | 15562190 |
| Bipolar Disorder, Diabetes Mellitus | Deregulated Nutrient Sensing | Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. | 15562197 |
| Inflammation | Deregulated Nutrient Sensing | Clinical and epidemiological data indicate that inflammation may be associated with insulin resistance. | 15562214 |
| Chronic infectious disease, Hypoalphalipoproteinemias | Deregulated Nutrient Sensing | Although a possible confounding variable could be a degree of insulin resistance within the group of patients with low HDL-C levels, our results indicate that C-reactive protein levels are increased in subjects with nonselected hypoalphalipoproteinemia and that chronic infections do not appear to mediate this relationship. | 15562377 |
| Hyperglycemia | Deregulated Nutrient Sensing | Insulin resistance after the androgen-deprivation therapy might lead to marked hyperglycemia in these patients. | 15562380 |
| Weight decreased | Deregulated Nutrient Sensing | In addition, weight reduction was achieved in patients with insulin resistance during this study. | 15563963 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance? | 15565368 |
| diabetic | Deregulated Nutrient Sensing | Previous studies have suggested that the high bone density often observed in type 2 diabetic patients may be explained by insulin resistance. | 15565368 |
| FBXO8 gene, Alcoholic Intoxication, Chronic | Deregulated Nutrient Sensing | The high-risk group was also associated with other non-lipid factors such as overweight -54% (BMI > 25Kg/m2), glucose intolerance-55% (FBS > 6.1 mmol/L), and alcoholism (55%). | 15565928 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD), a common entity in the general population, has been shown to be linked with insulin resistance and metabolic syndrome. | 15566509 |
| IGA Glomerulonephritis | Deregulated Nutrient Sensing | These same factors are central in the metabolic or insulin resistance syndrome and may have a pathogenetic role in the progression of IgAN. | 15572382 |
| Milk (body substance) | Deregulated Nutrient Sensing | High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys. | 15578035 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | They develop fasting hyperglycemia and glucose intolerance and are at risk for greater insulin resistance than mice lacking GLUT4 in only one tissue. | 15578099 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Genetic determinants limiting this "metabolic flexibility" may contribute to insulin resistance and type 2 diabetes in humans. | 15578099 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is the central defect in the development of type 2 diabetes, preceding its onset by 10-20 years. | 15579187 |
| Atherosclerosis | Deregulated Nutrient Sensing | Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations. | 15579191 |
| Atherosclerosis | Deregulated Nutrient Sensing | The aim of this study was to determine the correlations of plasma adiponectin concentration with insulin resistance and atherosclerosis. | 15579191 |
| Atherosclerosis | Deregulated Nutrient Sensing | The results suggest that adiponectin plays a role in lipid metabolism and correlates with atherosclerosis either directly or through insulin resistance. | 15579191 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. | 15582127 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Human plasma leptin and several indicators of insulin resistance were measured in 88 NAFLD patients and matched controls. | 15582127 |
| Fibrosis Assessment, Diabetes Mellitus | Deregulated Nutrient Sensing | By multivariate analysis, the significant association between leptin and fibrosis was abolished (adjusted P = 0.3) when controlling for confounders including age, gender, BMI, diabetes and insulin resistance. | 15582127 |
| Acquired (qualifier value) | Deregulated Nutrient Sensing | Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. | 15585588 |
| Intra-Abdominal Fat, Obesity | Deregulated Nutrient Sensing | We conclude that acquired obesity is associated with increases in intra-abdominal and liver fat and insulin resistance, independent of genetic factors. | 15585588 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | Twenty-five patients with stable angina and dyslipidemia undergoing clinical treatment were studied prospectively. | 15587571 |
| Dyslipidemias | Deregulated Nutrient Sensing | Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies. | 15587767 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | The sustained, favourable effects of pioglitazone on important components of diabetic dyslipidaemia may contribute to reduced cardiovascular disease risk, among patients with type 2 diabetes. | 15587767 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Probably as a result of hyperinsulinaemia associated with insulin resistance. | 15587841 |
| Tumor necrosis, Hypertensive (finding), diabetic | Deregulated Nutrient Sensing | Effect of amlodipine on insulin resistance & tumor necrosis factor-alpha levels in hypertensive obese type 2 diabetic patients. | 15591634 |
| Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Tumour necrosis factor-alpha (TNF-alpha) has been suggested to play a key role in insulin resistance (IR) in obesity and may contribute to the development of type 2 diabetes mellitus. | 15591634 |
| Fatty degeneration | Deregulated Nutrient Sensing | In nondiabetic subjects, a progressive (P < 0.05) increase in mean homeostasis model of insulin resistance was recorded from the group without steatosis to the groups with mild/moderate and severe steatosis. | 15598693 |
| Obesity | Deregulated Nutrient Sensing | Obesity per se increased the levels of the risk factors, but central adiposity contributed to a greater extent to adverse high-density lipoprotein-cholesterol, triglyceride, and insulin resistance levels. | 15601976 |
| Heart Failure, Diastolic | Deregulated Nutrient Sensing | Insulin resistance and inflammatory activation in older patients with systolic and diastolic heart failure. | 15604330 |
| Heart Failure, Diastolic, Inflammation, dihydrofolic acid binding | Deregulated Nutrient Sensing | To evaluate insulin resistance and systemic inflammation in older patients with systolic (SHF) or diastolic heart failure (DHF). | 15604330 |
| dihydrofolic acid binding | Deregulated Nutrient Sensing | Insulin resistance and inflammatory activation are present in older patients with SHF and DHF. | 15604330 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We hypothesized that the AIG(glu) decreases in Type 2 diabetes mellitus as a consequence of insulin resistance, whereas it remains intact in Type 1 diabetes. | 15606692 |
| Skeletal muscle structure, diabetic | Deregulated Nutrient Sensing | Because no changes in muscle blood flow were detected, insulin resistance appears to be the main cause for the observed decreased AIG(glu) in skeletal muscle in Type 2 diabetic patients. | 15606692 |
| Presenile dementia, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, insulin resistance, and dementia among HIV-1-infected patients. | 15608521 |
| Asthma, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia resolved or improved in 87% and asthma was cured or improved in 89% of those affected. | 15608802 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The overall age-standardised prevalence of diabetes (both known and newly diagnosed) was 10.6% and the age-standardised prevalence of insulin resistance was 37.0%. | 15608803 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes is a common disorder among this population, but insulin resistance is even more prevalent, especially among young age groups. | 15608803 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This is considerable cause for concern given that insulin resistance is believed to be the underlying cause of most cases of type 2 diabetes mellitus, and is confirmed by these data to be associated with a high degree of cardiovascular risk. | 15608803 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Men with type III hyperlipidemia had the highest calorie intake and those with type IV dyslipidemia had the highest alcohol intake. | 15611703 |
| Atherosclerosis | Deregulated Nutrient Sensing | Dietary patterns, insulin sensitivity and adiposity in the multi-ethnic Insulin Resistance Atherosclerosis Study population. | 15613260 |
| Heart Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The present study identified highly consistent associations of distinct dietary patterns with measures of insulin resistance and adiposity, which are risk factors for diabetes and heart disease. | 15613260 |
| Three Vessel Coronary Disease, Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients were predominantly men (70%), commonly presented with two- or three-vessel disease, and frequently had hypertension, a history of myocardial infarction and dyslipidemia. | 15614334 |
| Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | Accumulating evidence suggests that insulin resistance in patients with diabetes and the metabolic syndrome may impair endothelial function, uncovering a proinflammatory, proatherosclerotic vascular phenotype. | 15614340 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prevalence of comorbid hypertension and dyslipidemia and associated cardiovascular disease. | 15617368 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We found that 57.8% of all patients had hypertension or dyslipidemia; 30.7% had both. | 15617368 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Sixteen percent of all patients had diabetes mellitus, and 66.3% of these patients had concomitant hypertension and dyslipidemia. | 15617368 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | We hypothesized that insulin resistance would be associated with nondipping in patients who did not have frank diabetes mellitus or hypertension. | 15619409 |
| Increased insulin level, Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The polycystic ovary syndrome (PCOS) is characterized by insulin resistance with compensatory hyperinsulinemia. | 15623819 |
| Hyperandrogenemia, Prostate Cancer Outcomes Study, Acanthosis Nigricans | Deregulated Nutrient Sensing | Women with PCOS and the MBS differ from their counterparts lacking the MBS in terms of increased hyperandrogenemia, lower serum SHBG, and higher prevalence of acanthosis nigricans, all features that may reflect more severe insulin resistance. | 15623819 |
| TG gene | Deregulated Nutrient Sensing | A second component, related to the insulin resistance syndrome, may be principally genetic and associated with the high TG, low HDL, and LDL phenotype B observed in these Mexican children. | 15623835 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was a high prevalence of risk factors for ischemic heart disease (cigarette smoking, diabetes mellitus, hypertension and dyslipidemia) (65% had one or more risk factors) with no relation to educational level. | 15626273 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Insulin resistance is a typical feature of the obstructive sleep apnea syndrome (OSAS). | 15627868 |
| Weight decreased | Deregulated Nutrient Sensing | Dynamic strength training improves insulin sensitivity in men with insulin resistance independently on weight loss or increase in aerobic capacity. | 15628572 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance was observed in 31 treated patients (38%), of whom 22 (27%) had impaired glucose tolerance and six (7%) had diabetes mellitus. | 15628647 |
| Abnormal circulating valine concentration, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was the predominant metabolic abnormality in the treated group, observed in 58 patients (72%). | 15628647 |
| diabetic | Deregulated Nutrient Sensing | B. Ludvik et al., have recently shown the effect of Caiapo (Ipomoea batatas L.) on reducing fasting blood glucose and insulin resistance in type-2 diabetic patients. | 15630271 |
| Turban, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of type 2 diabetes and dyslipidemia in turban aboriginal populations is higher than that of their rural counterparts. | 15631206 |
| Metabolic Diseases, Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The degree of abnormalities in body fat depots and the degree of tissue insulin resistance were in parallel with the number of other metabolic diseases (hypertension and dyslipidemia) associated in type 2 diabetic patients. | 15631769 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension is often accompanied by other cardiovascular risk factors such as dyslipidemia, smoking, diabetes and increased body mass index (BMI). | 15633617 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes. | 15634339 |
| Diabetes Mellitus, Non-Insulin-Dependent, Traumatic injury | Deregulated Nutrient Sensing | Insulin resistance is a cardinal feature of type 2 diabetes and also a consequence of trauma such as surgery. | 15634339 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The insulin resistance directly after surgery and cell isolation was different from insulin resistance of type 2 diabetes; adipocytes from patients with type 2 diabetes remained insulin resistant after overnight incubation. | 15634339 |
| Kidney Failure, Chronic, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We propose that the elevated HbA1c level may be due to the repetitive exposure of patients' RBCs to the high glucose level in dialysate (200 mg/dl) or may reflect true glucose intolerance in non-diabetic patients with ESRD. | 15636425 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin is a new anti-inflammatory protein secreted exclusively by adipocytes and plays a protective role against insulin resistance and atherosclerosis. | 15638879 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Obesity, Chronic disease, Cerebrovascular Disorders, Hypertension, CTCAE | Deregulated Nutrient Sensing | Diabetes, coronary hearth disease, hypertension, cerebrovascular disease and dyslipidemia are chronic diseases associated with obesity. | 15641468 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | The excess risk associated with central obesity might be related to insulin resistance and hepatic steatosis. | 15645407 |
| Acromegaly, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study was performed to test the effect of neurosurgery in acromegaly (sharing at baseline insulin resistance but not increased visceral fat with type 2 diabetes) on insulin sensitivity, adiponectin concentrations and ALT activity. | 15653112 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Odds ratios of 1 kg increase in leg LTM were only significant for dyslipidaemia in men and hypercholesterolaemia in women (both 0.93). | 15656878 |
| MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder) | Deregulated Nutrient Sensing | Insulin resistance index and other clinical data were compared in sex-, age- and duration-matched MODY3 and MODYX patients. | 15657605 |
| Maturity Onset Diabetes of the Young Pathway | Deregulated Nutrient Sensing | A majority of Chinese MODY patients are due to defects in unknown genes and appear to be characterized by insulin resistance. | 15657605 |
| diabetic | Deregulated Nutrient Sensing | Insulin resistance decreased by 21.9% in the sibutramine-treated diabetic patients and by 38.5% in the nondiabetic group. | 15660196 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Adipose tissue distribution (visceral vs subcutaneous) has been shown to be an important predictor of insulin resistance, diabetes and cardiovascular disease, independent of body mass index. | 15672110 |
| Eye Abnormalities | Deregulated Nutrient Sensing | Leprechaunism is a rare congenital syndrome and the most severe form of insulin resistance syndrome, with mutations in the insulin receptor gene. | 15672252 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The development of insulin resistance is a critical step in the pathogenesis of type 2 diabetes. | 15673056 |
| Ventricular hypertrophy, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | Because mutations in the gene for AMP-activated protein kinase gamma2 (PRKAG2) cause an accumulation of cardiac glycogen and left ventricular hypertrophy that mimics hypertrophic cardiomyopathy, we hypothesized that hypertrophic cardiomyopathy might also be clinically misdiagnosed in patients with other mutations in genes regulating glycogen metabolism. | 15673802 |
| Dyslipidemias, atherosclerotic, diabetic | Deregulated Nutrient Sensing | Adiponectin, predominantly synthesized in the adipose tissue, seems to have substantial anti-inflammatory properties and to be a major modulator of insulin resistance and dyslipidemia, mechanisms that are associated with an increased atherosclerotic risk in diabetic patients. | 15677512 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Recently, insulin resistance (IR) was proposed as a primary pathogenic mechanism in non-alcoholic steatohepatitis (NASH). | 15682659 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Insulin resistance and depressive symptoms in middle aged men: findings from the Caerphilly prospective cohort study. | 15684022 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance in patients with chronic kidney disease. | 15685504 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | It has been reported that insulin resistance appears at an earlier stage of chronic kidney disease (CKD). | 15685504 |
| No metabolic abnormalities, Acidosis, Chronic Kidney Diseases | Deregulated Nutrient Sensing | However, few data are available concerning what factors of metabolic abnormalities, such as apolipoprotein (Apo) profile or acidosis, might be associated with insulin resistance in patients with CKD. | 15685504 |
| Decline in functional status | Deregulated Nutrient Sensing | We found that insulin resistance correlated linearly with decline in renal function. | 15685504 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Independent variables related to insulin resistance were bicarbonate and Apo A-1/B levels in patients with CKD. | 15685504 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes. | 15688209 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The degree of association varied in relation to the glycaemic status: no insulin resistance: r(2)=6.5% (p<0.001), insulin resistance without type 2 diabetes: r(2)=21.0% (p<0.001), type 2 diabetes: r(2)=25.4 (p<0.001). | 15688209 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Donor-related as well as nonimmunologic factors, such as hypertension and dyslipidemia, are associated with increased risk for renal allograft damage progression. | 15689401 |
| Obesity | Deregulated Nutrient Sensing | We conclude that increases in LpB:C-III in childhood and adolescence are associated with insulin resistance and obesity supporting the need for prevention programs. | 15690311 |
| Tumor necrosis | Deregulated Nutrient Sensing | Tumor necrosis factor alpha has a key role in insulin resistance. | 15690319 |
| Hyperglycemia, Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Metformin is able to reverse insulin resistance and hyperglycemia in high-risk subjects for type 2 diabetes mellitus independently of the effects on tumor necrosis factor alpha system activity. | 15690319 |
| TG gene, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Insulin resistance and obesity are associated with a dyslipidemia composed of high levels of triglycerides (TG), low levels of high-density lipoprotein cholesterol (HDL-C), and no change in level of low-density lipoprotein cholesterol (LDL-C). | 15690322 |
| Atherosclerosis | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study is a multicenter cohort study of middle-aged men and women. | 15690322 |
| Weight Gain, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | To determine the frequency and risk factors of NAFLD and chronological ordering between NAFLD, weight gain, and features of insulin resistance, a historical cohort study was conducted in a Japanese workplace. | 15690483 |
| Communicable Diseases, Injury of liver, Hepatitis B | Deregulated Nutrient Sensing | A cohort free of previous liver injury, alcohol consumption of more than 140 g/wk, and hepatitis B or C infection (529 of 1537 subjects), and a subcohort of 287 subjects free of insulin resistance-related features were identified. | 15690483 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Control of hypertension was achieved in 34.5%, dyslipidemia in 50.3% and diabetes in 35.5%. | 15691431 |
| Proteinuria, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Factors independently associated with a bad integral control were: diabetes (OR = 0.33; 95%CI: 0.23-0.47), dyslipidemia (OR = 0.34; 95%CI: 0.24-0.48), proteinuria (OR = 0.36; 95%CI: 0.18-0.71). | 15691431 |
| Proteinuria, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes, dyslipidemia or proteinuria predisposed to a worse control and the number of complementary tests performed to the patients was related to a better control. | 15691431 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | The findings suggest that metabolic syndrome and insulin resistance are not synonymous anthropometrically, metabolically, hemodynamically, or hormonally in patients with high-normal BP. | 15691610 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Adiponectin, insulin resistance, and left ventricular structure in dipper and nondipper essential hypertensive patients. | 15691614 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | In the absence of major cardiovascular risk factors, nondipper essential hypertensive patients show more prominent insulin resistance and lower adiponectin compared to dippers. | 15691614 |
| Refractory anemias, Cardiovascular morbidity, Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Cardiovascular morbidity and mortality appear to be enhanced in rheumatoid arthritis (RA), which might be due to an increased prevalence of cardiovascular risk factors such as dyslipidemia. | 15693084 |
| AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance. | 15698447 |
| Kidney Diseases | Deregulated Nutrient Sensing | The reasons for this association in the presence of nephropathy are unclear, but may be secondary to proatherogenic insulin resistance. | 15698447 |
| Dyslipidemias | Deregulated Nutrient Sensing | Following the educational program, the use of aspirin, clopidogrel, or warfarin increased from 69 to 99%, the use of beta- blockers increased from 57 to 98%, the use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers increased from 41 to 97%, and the use of lipid-lowering drugs in patients with dyslipidemia increased from 54 to 98% in patients without contraindications to these drugs. | 15705260 |
| Hypertriglyceridemia, Obesity | Deregulated Nutrient Sensing | The development of this complication is strongly associated with three clinical risk factors; specifically, insulin resistance, central obesity, and hypertriglyceridemia, however a genetic predisposition to THS has yet to be investigated. | 15706422 |
| Lupus Erythematosus, Discoid, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Our findings suggest that patients with cutaneous discoid lupus erythematosus have an increased risk of atherosclerosis due to the marked dyslipidemia associated with the disease. | 15708553 |
| Glucose Intolerance (disease), Obesity, Abdominal | Deregulated Nutrient Sensing | Recent studies show that African-Caribbean women who have a high level of internalized racism (INR) are at increased risk for abdominal obesity and glucose intolerance. | 15712783 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In women, increases of obesity indexes by quartile analyses showed linear increases of odds ratios for dyslipidemia (p values <0.01 by trend test). | 15716594 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | As a simple and non-invasive method for a detection of obesity and dyslipidemia, anthropometric measurements could be efficiently used in clinical and epidemiologic fields. | 15716594 |
| Proteinuria, Hypertension, CTCAE, Dyslipidemias, Hypoalbuminemia | Deregulated Nutrient Sensing | The patients presented with hypertension, significant proteinuria, hypoalbuminemia, and dyslipidemia. | 15717645 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | [Activated factor XII in patients with hyperglycaemia and dyslipidaemia]. | 15717806 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There are increased levels of FXIIa in patients with dyslipidaemia and also elevated levels of FXIIa have been reported in patients with diabetes mellitus. | 15717806 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Plasma leptin concentration in patients with Type 2 diabetes: relationship to cardiovascular disease risk factors and insulin resistance. | 15717875 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is common in Type 2 diabetes which, in turn, is associated with a markedly increased risk of cardiovascular disease. | 15717879 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Among patients with Type 2 diabetes, insulin resistance is not a risk factor for cardiovascular disease. | 15717879 |
| Myotonic Dystrophy, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | One of the clinical features of myotonic dystrophy is insulin resistance with non-obese diabetes mellitus (DM). | 15717887 |
| Myotonic Dystrophy | Deregulated Nutrient Sensing | Recently, the mechanism of insulin resistance in patients with myotonic dystrophy was revealed. | 15717887 |
| Increased insulin level, Myotonic Dystrophy, Demographics Domain | Deregulated Nutrient Sensing | It is important to choose the optimal treatment for DM in myotonic dystrophy, because the patients have hyperinsulinemia caused by specific mechanism and could not reduce the insulin resistance. | 15717887 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Ethnic, gender, and age-related differences in treatment and control of dyslipidemia in hypertensive patients. | 15720044 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | These data were confirmed after the stratification of patients into younger (<65 y) and older (>/=65 y) or into subjects with and without a family history of dyslipidemia or vascular diseases. | 15721016 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | This dyslipidemia increased the risk of coronary disease by 50% over 10 years. | 15721096 |
| Dyslipidemias | Deregulated Nutrient Sensing | There are increasing reports of dyslipidemia and cardiovascular events associated with highly active antiretroviral therapy. | 15721096 |
| Dyslipidemias, HIV | Deregulated Nutrient Sensing | Accordingly, minimizing dyslipidemia associated with highly active antiretroviral therapy may preserve life expectancy among adults who have the human immunodeficiency virus. | 15721096 |
| Fibrosis, Liver, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance is associated with liver fibrosis in non-diabetic chronic hepatitis C patients. | 15726693 |
| Steatohepatitis, Fibrosis Assessment, Hepatitis C | Deregulated Nutrient Sensing | We measured the levels of insulin resistance (as HOMA score) and leptin in 221 non-diabetic chronic hepatitis C patients, to assess their impact on liver steatosis and fibrosis, relative to other factors, using a multivariable logistic regression. | 15726693 |
| Fatty degeneration | Deregulated Nutrient Sensing | Levels of insulin resistance were not correlated with the presence of steatosis. | 15726693 |
| Hepatitis C, fibrogenesis | Deregulated Nutrient Sensing | Thus, insulin resistance (but not leptin) may play a role in fibrogenesis in chronic hepatitis C patients infected with genotype non-3. | 15726693 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Sex disparity in the management of dyslipidemia among patients with type 2 diabetes mellitus in a managed care organization. | 15726854 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine whether there were sex-related differences in the management of dyslipidemia among managed care enrollees with diabetes mellitus. | 15726854 |
| Arterial Stiffness, Hypertensive (finding) | Deregulated Nutrient Sensing | Arterial stiffness is related to insulin resistance in nondiabetic hypertensive older adults. | 15728211 |
| Arterial Stiffness, Hyperglycemia | Deregulated Nutrient Sensing | Both insulin resistance and hyperglycemia may contribute to the development of arterial stiffness. | 15728211 |
| Arterial Stiffness, Hypertensive (finding) | Deregulated Nutrient Sensing | Older nondiabetic hypertensive adults were recruited to test the following hypotheses: (1) insulin resistance is associated with arterial stiffness, and (2) this relationship is independent of glucose tolerance status. | 15728211 |
| Arterial Stiffness, Hypertensive (finding) | Deregulated Nutrient Sensing | These results suggest that in hypertensive, nondiabetic, older adults, insulin resistance is associated with arterial stiffness independent of glucose tolerance status. | 15728211 |
| Increased insulin level, Obesity | Deregulated Nutrient Sensing | The role of ghrelin in childhood obesity, a state associated with hyperinsulinism and insulin resistance, is not fully understood. | 15728212 |
| Obesity | Deregulated Nutrient Sensing | Alterations in ghrelin suppression in OW children may be yet another manifestation of the insulin resistance of obesity. | 15728212 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We identified a mitochondrial intramembrane protease, known as presenilins-associated rhomboid-like protein (PSARL) that is associated with insulin resistance and type 2 diabetes. | 15729572 |
| Communicable Diseases, Chlamydia, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | [Chlamydia pneumoniae infection increases the risk of coronary artery disease in the patients with dyslipidemia]. | 15730813 |
| Communicable Diseases, Chlamydia, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | To investigates the role of chlamydia pneumoniae (CP) infection in the development of coronary artery disease (CAD) in the patients with dyslipidemia, and to examine the gender related differences in this role. | 15730813 |
| Dyslipidemias | Deregulated Nutrient Sensing | CP infection increases the risk of CAD only in patients with dyslipidemia, and this increase was greater in women than in men. | 15730813 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) frequently coexists with obesity, diabetes, and dyslipidemia. | 15731489 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Contribution of abdominal visceral obesity and insulin resistance to the cardiovascular risk profile of postmenopausal women. | 15734855 |
| Pre-Eclampsia | Deregulated Nutrient Sensing | Compared to women with uncomplicated pregnancies, those with a history of preeclampsia had significantly elevated levels of fasting serum triglycerides, insulin and glucose, and a higher fasting insulin resistance index, suggesting that women with prior preeclampsia were relatively insulin resistant. | 15735370 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. | 15736103 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We studied the correlation between the adiponectin-leptin (A/L) ratio and parameters of insulin resistance in 220 Japanese patients with type 2 diabetes (138 men and 82 women). | 15736103 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results suggested that the A/L ratio was effective in relevance as a parameter of insulin resistance to adiponectin or leptin alone, and a more sensitive and reliable marker of insulin resistance than HOMA-R as the FPG level elevated, in patients with type 2 diabetes. | 15736103 |
| diabetic | Deregulated Nutrient Sensing | Red wine consumption improves insulin resistance but not endothelial function in type 2 diabetic patients. | 15736107 |
| diabetic | Deregulated Nutrient Sensing | To determine whether red wine improves insulin resistance in diabetic patients and to explore the relation between insulin sensitivity and endothelial function, we studied vascular reactivity and insulin-mediated glucose uptake in 9 type 2 diabetic patients before and after 2 weeks of red wine consumption (360 mL/d, wine-treated diabetics) and 8 type 2 diabetic patients who did not consume wine (control diabetics). | 15736107 |
| diabetic | Deregulated Nutrient Sensing | In conclusion, red wine consumption for 2 weeks markedly attenuates insulin-resistance in type 2 diabetic patients, without affecting vascular reactivity and nitric oxide production. | 15736107 |
| diabetic | Deregulated Nutrient Sensing | Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients. | 15736116 |
| diabetic | Deregulated Nutrient Sensing | From these results, it can be concluded that in conjunction with serum triglycerides and serum leptin, serum E-selectin is another important independent factor associated with insulin resistance in nonobese Japanese type 2 diabetic patients. | 15736116 |
| Hypertensive disease | Deregulated Nutrient Sensing | In conclusion, cellular insulin resistance in EBV-transformed lymphoblasts is associated with young Japanese subjects with HBP. | 15736115 |
| Primary malignant neoplasm, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The Trp64Arg polymorphism in the beta3AR gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes; little is known about its possible association with cancer. | 15743038 |
| Kidney Diseases | Deregulated Nutrient Sensing | Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. | 15743998 |
| Renal Insufficiency, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In patients with chronic kidney diseases, a syndrome of insulin resistance is present even in the earliest stage of renal dysfunction, and several components of this syndrome are associated with CV events. | 15743998 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma adiponectin and insulin resistance in Korean type 2 diabetes mellitus. | 15744804 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, which implies impairment of insulin signaling in the target tissues, is a common cause of type 2 diabetes. | 15744804 |
| diabetic | Deregulated Nutrient Sensing | In conclusion, the plasma adiponectin concentrations were closely related to the insulin resistance parameters in Korean type 2 diabetic patients. | 15744804 |
| Peripheral Vascular Diseases, Hypoglycemia | Deregulated Nutrient Sensing | Unfortunately, first-and second-generation beta-blockers are associated with the worsening of insulin resistance, deterioration of glycemic control, peripheral vasoconstriction, potentially worsening peripheral vascular disease, and more frequent and severe hypoglycemia. | 15745836 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Ischemic non-embolic stroke in the elderly is associated with dyslipidemia and several predictor metabolic factors, which could be substantially modified by lifestyle changes and therapeutic intervention. | 15749186 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The 64Arg allele, which had a frequency of 0.22, was not associated with obesity, type 2 diabetes mellitus, dyslipidemias, or hypertension. | 15751274 |
| Dyslipidemias, Peripheral Arterial Diseases, Diabetes Mellitus, Infarction, Chronic Obstructive Airway Disease, Depression, CTCAE, Cerebrovascular Disorders, Hypertensive (finding), Kidney Failure | Deregulated Nutrient Sensing | In the univariate analysis, hypertensive subjects presented more frequently non-Q-wave infarction and ST segment depression than did normotensive subjects, even if hypertensive subjects more frequently had diabetes, dyslipidemia, renal failure, peripheral artery disease, cerebrovascular disease, and chronic obstructive pulmonary disease (P < .01 for all). | 15752942 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are common features of Type 2 Diabetes. | 15754730 |
| Diabetes, Autoimmune, diabetic | Deregulated Nutrient Sensing | Main positive change observed in patients received only diabetic diet, where was a decrease of insulin resistance and in patients with latent autoimmune diabetes (type LADA), where was a increase insulin secretion and decrease of daily dose of insulin requiring. | 15754961 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin, an adipocyte-derived protein, seems to be a link between obesity, insulin resistance, and atherosclerosis. | 15758248 |
| Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Such a relationship has been considered by others concerning the well-described association between diabetes and carcinoma of the pancreas, in which the underlying pathophysiologic process seems to be insulin resistance. | 15760789 |
| Dyslipidemias, Hepatitis C | Deregulated Nutrient Sensing | Baseline cholesterol > 200 mg/dL and triglycerides > 150 mg/dL were independent risk factors for dyslipidaemia, while hepatitis C coinfection appeared to be protective. | 15761071 |
| Dyslipidemias, Coronary Artery Disease, emotional dependency, Diabetes Mellitus | Deregulated Nutrient Sensing | No association, however, was found in group A between MPV and age, gender, duration of diabetes, insulin dependency, BMI, HbA1c, coronary artery disease or dyslipidaemia. | 15763888 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance plays an important role in the pathogenesis of coronary artery disease (CAD). | 15765163 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. | 15765399 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | We evaluated the effect of insulin resistance and viral factors on sustained virological response in patients with chronic hepatitis C treated with peginterferon plus ribavirin. | 15765399 |
| Fibrosis Assessment, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance, fibrosis, and genotype are independent predictors of the response to antiviral therapy in chronic hepatitis C patients treated with peginterferon plus ribavirin. | 15765399 |
| Microalbuminuria, Dyslipidemias, Electrocardiogram: left ventricle hypertrophy (finding), Cardiovascular Diseases | Deregulated Nutrient Sensing | In men, furthermore, mortality was predicted by previous cardiovascular disease, left ventricular hypertrophy and microalbuminuria, whilst in women mortality was predicted by high blood pressure and dyslipidemia. | 15765637 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and diabetes mellitus were all present in 43.3% of men and 29.1% of women with obesity class 3. | 15767503 |
| Increased insulin level, Angina Pectoris, Variant | Deregulated Nutrient Sensing | Insulin resistance relates to acetylcholine-induced microvascular vasoconstriction in a patient with vasospastic angina: potential implication of causalities between hyperinsulinemia and coronary microcirculation failure. | 15772782 |
| Chest Pain | Deregulated Nutrient Sensing | Microvascular vasoconstriction must be considered when a patient with insulin resistance presents with chest pain. | 15772782 |
| Premature aging syndrome | Deregulated Nutrient Sensing | Reduced phosphorylation of transcription factor Elk-1 in cultured fibroblasts of a patient with premature aging syndrome and insulin resistance. | 15772901 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The relative change in MFVR and M/IG were inversely related, supporting the hypothesis that peripheral vascular changes in hypertension may induce insulin resistance. | 15775796 |
| Dyslipidemias | Deregulated Nutrient Sensing | The higher postprandial HBA levels reflect increased hepatic FFA delivery and may aggravate insulin resistance and dyslipidemia, leading to increased cardiovascular risk. | 15784707 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia, especially lowered high-density lipoprotein cholesterol, also played an important role (HR=2.09, 95% CI=1.33-3.29) in CHD events. | 15785294 |
| Diabetes Mellitus, Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity. | 15787895 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is well recognized both in type 1 diabetes mellitus (T1DM) and in obesity. | 15787895 |
| Overweight | Deregulated Nutrient Sensing | Studies concerning the relation between insulin resistance and overweight in T1DM have not yet been carried out. | 15787895 |
| Overweight | Deregulated Nutrient Sensing | T1DM children with insulin resistance based on ID/kg are not more overweight than insulin-sensitive children with T1DM. | 15787895 |
| Overweight | Deregulated Nutrient Sensing | ID/m2 and ID/IW seem to reflect a better tool than ID/kg to describe the influence of overweight on insulin resistance in T1DM. | 15787895 |
| Inflammation, Tumor necrosis | Deregulated Nutrient Sensing | Increased levels of inflammation markers, such as C-reactive protein (CRP) and tumor necrosis factor-alpha , have been found in insulin resistance syndrome. | 15791041 |
| Lipemia - observation, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Increased postprandial lipemia is part of diabetic dyslipidemia and is associated with accelerated atherosclerosis. | 15793183 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased urinary albumin excretion, insulin resistance, and related cardiovascular risk factors in patients with type 2 diabetes: evidence of a sex-specific association. | 15793194 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | While the relevant role of insulin resistance in the pathogenesis of increased urinary albumin excretion (UAE) is well established in type 1 diabetes, its contribution in type 2 diabetes is controversial. | 15793194 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our aim was to investigate whether insulin resistance was associated with increased UAE in a large cohort of patients with type 2 diabetes. | 15793194 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Finally, ACR was significantly higher in men with two or more insulin resistance-related cardiovascular risk factors (i.e., abdominal obesity, dyslipidemia, and arterial hypertension) than in men with fewer than two insulin resistance-related cardiovascular risk factors (0.90 [0.2-115.1] vs. 1.56 [0.1-1367.6], respectively, P = 0.005). | 15793194 |
| diabetic | Deregulated Nutrient Sensing | In type 2 diabetic patients, increased UAE is strongly associated with insulin resistance and related cardiovascular risk factors. | 15793194 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The definition of dyslipidemia in patients with hypertension was used only when triglyceride or HDL-cholesterol was at abnormal level. | 15793775 |
| Hypertensive (finding), Dyslipidemias, Metabolic Syndrome X | Deregulated Nutrient Sensing | The LPL H-X haplotype was one of the protective factors of dyslipidemia of metabolic syndrome in hypertensive patients. | 15793775 |
| Retinal Dystrophies, Blindness, hearing impairment, Obesity, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alstrom syndrome is a recessively inherited genetic disorder characterized by congenital retinal dystrophy that leads to blindness, hearing impairment, childhood obesity, insulin resistance, and type 2 diabetes mellitus. | 15795345 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. | 15797948 |
| Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Mitochondrial dysfunction has been reported to contribute to insulin resistance (IR) in the elderly and type 2 diabetes. | 15798952 |
| metabolic disturbance | Deregulated Nutrient Sensing | Decreased insulin sensitivity, a delayed biological effect, and insulin resistance may serve as the early predictors of carbohydrate metabolic disturbances and severe metabolic pathology. | 15801640 |
| Uremia | Deregulated Nutrient Sensing | It is known that insulin resistance in uraemia may be improved with erythropoietin (EPO) and vitamin D therapy. | 15802034 |
| Uremia | Deregulated Nutrient Sensing | A two-month EPO therapy significantly decreased PC-1 activity to the control values, suggesting that an effect on PC-1 expression could be implicated in the amelioration of insulin resistance in uraemic patients treated with EPO. | 15802034 |
| MULTISYSTEM DISORDER, HAIR-AN syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | The HAIR-AN syndrome is a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). | 15802076 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance measured by the euglycaemic insulin clamp predicts subsequent CHD in elderly men. | 15803331 |
| Uremia | Deregulated Nutrient Sensing | Experimental studies have shown that increased levels of parathyroid hormone (PTH) in uremia may cause elevation of intracellular calcium, predisposing to insulin resistance and lipid metabolism abnormalities. | 15807180 |
| Obesity, Abdominal, Atherosclerosis | Deregulated Nutrient Sensing | Abdominal obesity predicts declining insulin sensitivity in non-obese normoglycaemics: the Insulin Resistance Atherosclerosis Study (IRAS). | 15811139 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Waist circumference should be considered, in addition to BMI, when identifying individuals at high risk of diabetes or the insulin resistance syndrome. | 15811139 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients. | 15811141 |
| Ventricular Fibrillation | Deregulated Nutrient Sensing | This was associated with WHR reduction, decreases in VF and insulin resistance. | 15811141 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Cerivastatin increases FVR responses to ACH in type 2 diabetic men with mild dyslipidaemia but only following NO synthase inhibition. | 15811145 |
| Morbid obesity | Deregulated Nutrient Sensing | 59 patients with morbid obesity were studied with anthropometric assessment and with carbohydrate metabolism assessment through an oral glucose overload and measurement of insulin resistance, before and after a dietary intervention alternating diets of very low caloric content with conventional low-calorie diets. | 15811276 |
| Dyslipidemias | Deregulated Nutrient Sensing | Quantitative effect of glycaemic improvement on the components of diabetic dyslipidaemia: a longitudinal study. | 15811569 |
| Dyslipidemias | Deregulated Nutrient Sensing | Bivariate correlations and step-wise, multivariate analysis were performed to find predictors of change in the different components of diabetic dyslipidaemia. | 15811569 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, for the component of diabetic dyslipidaemia for which less therapeutic tools are available, glycaemic improvement is most effective. | 15811569 |
| Impaired health, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In addition, nonobese elderly persons with type 2 diabetes show a marked impairment in insulin release accompanied by mild insulin resistance, whereas obese elderly persons have marked insulin resistance in the presence of "adequate" levels of insulin. | 15814869 |
| Cell secretion | Deregulated Nutrient Sensing | Marked beta secretory defects seem to be the rule, whereas a significant degree of insulin resistance is unusual. | 15814869 |
| Hypertensive (finding), Dyslipidemias, Blood Pressure | Deregulated Nutrient Sensing | The use of antiplatelet drugs, lipid-lowering drugs for dyslipidemia, beta blockers, and ACE inhibitors or angiotensin-receptor blockers, reduction of blood pressure to <140/90 mmHg in hypertensive persons, and reduction of hemoglobin A1c in diabetics to <7% in older persons with PAD needs to be increased in all clinical settings. | 15814871 |
| Overweight, Obesity | Deregulated Nutrient Sensing | Owing the strong correlations between components of the MS and obesity with hs-CRP levels, previous studies about the associations of hs-CRP with insulin resistance might have been confounded by the inclusion of overweight or dysmetabolic subjects. | 15816996 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was defined as TC > or = 220 mg/dl or TG > or = 150 mg/dl. | 15830273 |
| Kidney Failure, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | The cumulative incidences of ESRD, per 1000 screenees, were 1.12 for those without dyslipidemia and 2.53 for those with dyslipidemia. | 15830273 |
| Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance in men with treated hypertension at increased risk for cardiovascular disease: results of a 3-year study. | 15831352 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is an independent risk factor for cardiovascular disease. | 15831352 |
| Heart Diseases, Obesity, Hereditary | Deregulated Nutrient Sensing | Hereditary antecedents: AHT--46.8%; ischemic cardiopathy and myocardial infarction--15.6%; obesity and dyslipidemia--15.0%; stroke--10.8%. | 15832974 |
| Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | These results are promising for health care providers providing advice to postmenopausal women for lifestyle changes to reduce risk of insulin resistance, coronary heart disease, and diabetes. | 15833948 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Fifty-two percent of patients had dyslipidemia, and 87.6% were overweight, obese, or morbidly obese; tobacco use was documented in 19.5%. | 15839181 |
| Dyslipidemias, Overweight, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Quality improvement programs should emphasize the importance of treating hypertensive diabetic patients to their goal BP, as well as controlling other major cardiovascular disease risk factors, such as smoking, dyslipidemia, and overweight or obesity, that are prevalent among these high-risk patients. | 15839181 |
| hepato-renal | Deregulated Nutrient Sensing | Insulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients. | 15840056 |
| Kidney Failure, Acute, Critical Illness | Deregulated Nutrient Sensing | Insulin resistance in critically ill patients with acute renal failure. | 15840772 |
| Hyperglycemia, Acute respiratory failure, Critical Illness | Deregulated Nutrient Sensing | Hyperglycemia associated with insulin resistance has been associated with adverse outcomes in critically ill intensive care unit (ICU) patients but has not been examined specifically in patients with ARF. | 15840772 |
| Survivors | Deregulated Nutrient Sensing | Mean insulin concentrations were significantly higher (431 +/- 508 vs. 234 +/- 189 pmol/l, P = 0.03), mean homeostasis model of insulin resistance levels were significantly higher (24.1 +/- 30.0 vs. 11.7 +/- 12.5, P = 0.04), and IGFBP-3 concentrations were significantly lower (1,190 +/- 498 vs. 1,470 +/- 581 microg/l, P = 0.02) among nonsurvivors compared with survivors. | 15840772 |
| Hyperglycemia, Acute respiratory failure, Critical Illness | Deregulated Nutrient Sensing | Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. | 15840772 |
| Cerebrovascular Disorders, Diabetes Mellitus, Insulin-Dependent, Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | The present association between low serum HDL-cholesterol and ischaemic stroke patients suggests that aggressive management of dyslipidaemia may protect against cerebrovascular disease in Type 1 diabetes. | 15842508 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. | 15842511 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects. | 15842511 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | For the ABCC8 exon 18 and the KCNJ11 variant, associations were stronger for studies of clinical diabetes than newly detected glucose intolerance. | 15842514 |
| Glucose Intolerance (disease), Aniridia | Deregulated Nutrient Sensing | PAX6 is also involved in the development of the endocrine pancreas, and reported to be a genetic factor common to aniridia and glucose intolerance, although the latter is usually mild. | 15842522 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Statins have been shown to significantly reduce morbidity and mortality in patients with coronary artery disease (CAD), and also in patients with dyslipidaemia when statins are taken regularly. | 15842555 |
| Dyslipidemias, Myopathy | Deregulated Nutrient Sensing | Because the risk for myopathy increases when 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) are used with other agents known to inhibit cytochrome P450 3A4 in patients with dyslipidemia, we sought to quantify this risk in a diverse, real-world sample of patients receiving statin therapy. | 15843281 |
| Obesity | Deregulated Nutrient Sensing | The adipokine resistin is suggested to be an important link between obesity and insulin resistance. | 15843582 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance predisposes to cardiovascular disease and shortens human lifespan. | 15851602 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Data on associations between dietary patterns and the risk of insulin resistance and type 2 diabetes are sparse. | 15853117 |
| Dyslipidemias | Deregulated Nutrient Sensing | Pioglitazone, alone and with metformin, improved lipid components of diabetic dyslipidaemia more than did their respective comparison groups. | 15854187 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Awareness and treatment of dyslipidemia in young adults with type 1 diabetes. | 15855566 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia is a preventable major risk factor for coronary heart disease (CHD). | 15855566 |
| Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Despite an increased risk of CHD in type 1 diabetes, little is known concerning awareness and adequacy of dyslipidemia treatment in this population. | 15855566 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Type 1 diabetic subjects had significantly less dyslipidemia than nondiabetic control subjects (47 vs. 58%, P < 0.001), and a higher percentage of those with abnormal lipids were aware of (52 vs. 34%, P < 0.0001), on medication for (36 vs. 9%, P < 0.0001), and in control of their lipid levels (15 vs. 1.4%, P < 0.001). | 15855566 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia, a major risk factor for CHD, remains largely undiagnosed and undertreated in high-risk populations, such as patients with type 1 diabetes. | 15855566 |
| Acute Coronary Syndrome, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance is common in Japanese patients with acute coronary syndrome who were not previously diagnosed with diabetes. | 15855586 |
| Glucose Intolerance (disease), Pancreatic carcinoma | Deregulated Nutrient Sensing | Beta-cell function and insulin resistance evaluated by HOMA in pancreatic cancer subjects with varying degrees of glucose intolerance. | 15855820 |
| Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes associated with pancreatic cancer is likely due to a combination of marked decline in BCF and increased insulin resistance. | 15855820 |
| Glucose Intolerance (disease), Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, we studied 73 pancreatic cancer subjects with glucose intolerance; 21 had impaired FPG and 51 had diabetes. | 15855820 |
| Increased insulin level | Deregulated Nutrient Sensing | fasting hyperinsulinemia (>20.0 microIU/ml) in 32.2%, insulin resistance (I/G>0.30) in 73.7%; in the group of patients with hyperinsulinemia 66.7% had abdominal adiposity. | 15858253 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptor-gamma (PPARgamma) has been hypothesized as being involved in colorectal cancer given its role in adipocyte development and insulin resistance. | 15860437 |
| Dyslipidemias | Deregulated Nutrient Sensing | Hemodialysis patients have uremic dyslipidemia, represented by elevated serum intermediate-density lipoprotein cholesterol (IDL-C) levels, and an increased cardiovascular mortality rate. | 15861352 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Long-term blockade of the renin-angiotensin system may have a beneficial effect on the acceleration of atherosclerosis and uremic dyslipidemia. | 15861352 |
| Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | We propose that POMC is among the likely susceptibility genes for osteoporosis and may also be involved in dyslipidemia. | 15864412 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Concurrent hypertension and dyslipidemia; obesity and dyslipidemia; and hypertension and obesity occurred in 44.4%, 42.5% and 33.1% of type-2 diabetics, respectively. | 15868776 |
| Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | In view of these results, it could be speculated that the adiponectin gene variant, or a mutation in linkage with it, determines lower adiponectin gene expression, causing in turn an increased risk to develop insulin resistance, atherosclerosis and cardiovascular disease. | 15877215 |
| Dyslipidemias, Chronic disease, Obesity | Deregulated Nutrient Sensing | The nutritional status was inadequate due to the prevalence of obesity, which results in the appearance of other chronic diseases, such as dyslipidemias. | 15880207 |
| Prostate carcinoma | Deregulated Nutrient Sensing | High insulin levels and insulin resistance have been implicated in prostate cancer development, which has prompted a recent investigation of a possible role for germline variation in the insulin gene (INS) and prostate cancer risk. | 15880482 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | A cross-sectional survey of lipid levels, cardiovascular disease and risk factors in outpatients treated for dyslipidemia. | 15882669 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | While a strong inverse association has been reported between dairy consumption and the insulin resistance syndrome among young obese adults, the relation between dairy intake and type 2 diabetes is unknown. | 15883237 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | The mechanism of hypoadiponectinemia in patients with FRSPH is probably independent of insulin resistance. | 15884764 |
| Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Adiponectin, an adipocyte-derived hormone found in lower concentration with greater adiposity, is suggested to reduce the risk of insulin resistance, atherosclerosis, and cardiovascular disease. | 15886241 |
| Glucose Intolerance (disease), Illness (finding) | Deregulated Nutrient Sensing | Diminished tissue sensitivity to beta-adrenergic signals may contribute to the impaired insulin response and exaggerated glucose intolerance displayed by older patients after injury and during acute illness. | 15887790 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence and control of dyslipidemia among persons with diabetes in the United States. | 15890427 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Many persons with diabetes remain uncontrolled for dyslipidemia. | 15890427 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Increased plasma leptin levels with aging suggest resistance to leptin action and may explain why elderly subjects have abdominal obesity and insulin resistance. | 15893114 |
| Dyslipidemias, Cardiovascular Diseases, Atherosclerosis | Deregulated Nutrient Sensing | Chronic hemodialysis patients show a high incidence and prevalence of cardiovascular disease of multifactorial etiology and an association between dyslipidemia and accelerated atherosclerosis. | 15893756 |
| Diabetes Mellitus, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident | Deregulated Nutrient Sensing | Body mass index (OR 1.08; 95% CI 1.05-1.11), diabetes mellitus (1.4; 1.09-1.79), ischemic heart disease (1.38, 1.08-1.75) and stroke (1.30; 1.0-1.69) were independent factors associated with dyslipidemia. | 15893756 |
| Schizophrenia, Obesity | Deregulated Nutrient Sensing | Gender differences in association of plasma adiponectin with obesity reflect resultant insulin resistance in non-diabetic Japanese patients with schizophrenia. | 15896219 |
| Adenoma of large intestine | Deregulated Nutrient Sensing | Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance. | 15897559 |
| Carcinogenesis, Obesity, Abdominal | Deregulated Nutrient Sensing | Colorectal carcinogenesis is thought to be related to abdominal obesity and insulin resistance. | 15897559 |
| Carcinogenesis, Obesity, Abdominal | Deregulated Nutrient Sensing | This study may offer a new insight to understanding the relationship of colorectal carcinogenesis with abdominal obesity and insulin resistance. | 15897559 |
| Apolipoproteins B, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | A potential role of apolipoprotein B in the risk stratification of diabetic patients with dyslipidaemia. | 15904989 |
| Dyslipidemias | Deregulated Nutrient Sensing | Diabetic dyslipidaemia is characterised by retention of atherogenic particles, which are depleted of cholesterol. | 15904989 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined the potential role of apolipoprotein B in the risk stratification of Omani patients with type 2 diabetes and dyslipidaemia. | 15904989 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | These findings suggest that the ratios of apoB/LDL cholesterol and apoB/non-HDL cholesterol may have a role in the risk stratification of diabetic patients with dyslipidaemia. | 15904989 |
| Dyslipidemias | Deregulated Nutrient Sensing | Measuring VLDL-cholesterol may be helpful for understanding the pathological features of diabetic dyslipidaemia. | 15907189 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The rates of overweight, obesity, and dyslipidemia rose significantly (p < 0.05) independently from age, federal state, and gender. | 15909748 |
| Obesity | Deregulated Nutrient Sensing | This risk was independent of age, sex, obesity, triglyceride level, HDL cholesterol and pattern of insulin resistance. | 15910632 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | A multivariate statistical analysis showed that male sex, age, and dyslipidaemia were independent predictors of critical atherosclerosis. | 15917275 |
| Obesity | Deregulated Nutrient Sensing | Both total and central obesity are associated with insulin resistance and with an atherogenic lipoprotein profile. | 15917851 |
| Acanthosis Nigricans, Polycystic Ovary Syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | Particular forms of polycystic ovary syndrome with severe hyperandrogenism, acanthosis nigricans, and marked insulin resistance, defining the type A insulin resistance syndrome, are due to insulin receptor gene mutations. | 15919811 |
| Acanthosis Nigricans, Lipodystrophy | Deregulated Nutrient Sensing | This mutation cosegregated with impaired glucose tolerance, insulin resistance, and acanthosis nigricans in the absence of clinical lipodystrophy in the family. | 15919811 |
| Disease | Deregulated Nutrient Sensing | This study further extends the vast range of diseases linked to LMNA mutations and identifies another genetic cause for the type A insulin resistance syndrome. | 15919811 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To test the hypothesis that lower vital capacity is cross-sectionally associated with features of insulin resistance and is an independent predictor of incident type 2 diabetes. | 15920070 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Pulmonary factors related to vital capacity deserve attention as possible risk factors for insulin resistance and diabetes. | 15920070 |
| square decimeter | Deregulated Nutrient Sensing | beta-Cell function declined significantly in the patients with IGT and DM2, and insulin resistance increased significantly. | 15921179 |
| Obesity, Structure of posterior cerebral artery | Deregulated Nutrient Sensing | Because insulin resistance in the setting of obesity is associated with the development of PCa, we hypothesized that decreased adiponectin levels might underlie the association between PCa and obesity/insulin resistance. | 15922427 |
| Asthma, Allergy - Charge Type Reason | Deregulated Nutrient Sensing | The authors hypothesise that insulin resistance may play a role in asthma and allergy. | 15923242 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Hyperglucagonemia has been described to be associated with insulin resistance in patients with liver cirrhosis. | 15926112 |
| Dyslipidemias, Multiple Chronic Conditions, Depression, CTCAE, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients had multiple diseases including type 2 diabetes mellitus (n = 23), hypertension (n = 48), depression (n = 18), and dyslipidemia (n = 9). | 15928261 |
| Vascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The cross-sectional IRIS-II study tried to assess the prevalence of insulin resistance and macrovascular disease in orally treated patients with Type 2 diabetes. | 15929679 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | The results confirm that fasting intact proinsulin is a suitable measure for beta-cell dysfunction and insulin resistance in type 2 diabetes and may be used to support therapeutic decisions. | 15929679 |
| Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance and postprandial triglyceride levels in primary renal disease. | 15931621 |
| No metabolic abnormalities, Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Renal failure is associated with a range of metabolic abnormalities including insulin resistance and dyslipidemia. | 15931621 |
| Kidney Failure, Kidney Diseases | Deregulated Nutrient Sensing | We examined the role of creatinine clearance (CrCl) and body composition in the development of insulin resistance in patients with primary renal disease and a variable degree of renal failure. | 15931621 |
| Decline in functional status | Deregulated Nutrient Sensing | Insulin resistance increased with decline in renal function and was significantly higher in patients with CrCl less than 60 mL/min compared to subjects with CrCl greater than 60 mL/min or carefully matched controls. | 15931621 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Genetic polymorphism of apo E has been reported as an important dyslipidemia genetic marker associated with coronary artery disease. | 15936467 |
| Dyslipidemias | Deregulated Nutrient Sensing | We think that these results corroborate that in the etiology of the dyslipidemia, there is more than one associate genetic marker. | 15936467 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | The metabolic syndrome and insulin resistance: relationship to haemostatic and inflammatory markers in older non-diabetic men. | 15939060 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Most were taking medications for hypertension (67%) and dyslipidemia (62%). | 15939916 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Group I comprised patients with insulin resistance, abnormal fasting blood glucose or glucose tolerance, type 2 diabetes. | 15940190 |
| Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Protective food commodities in the prevention of cardiovascular disease, insulin resistance syndrome or diabetes are crucial components of the vegetarian diet. | 15940383 |
| Dyslipidemias | Deregulated Nutrient Sensing | Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. | 15941898 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased serum resistin levels in patients with type 2 diabetes are not linked with markers of insulin resistance and adiposity. | 15944845 |
| Hyperlipidemia, Obesity | Deregulated Nutrient Sensing | However, there was no correlation in either patient group between serum resistin levels and markers of insulin resistance, obesity or hyperlipidaemia. | 15944845 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Taken together, these findings demonstrate that serum resistin levels are increased in patients with type 2 diabetes, but this increase is not linked to markers of insulin resistance or adiposity. | 15944845 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Gastric bypass has repeatedly been shown to improve and even cure type 2 diabetes by substantially improving insulin resistance. | 15946424 |
| Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The changes in insulin resistance seen after gastric bypass, which are responsible for the resolution or improvement of type 2 diabetes occur within 6 days of the surgery, before any appreciable weight loss has occurred. | 15946424 |
| Arthropathy, Dyslipidemias, Morbid obesity, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Regarding the diseases associated with morbid obesity, arterial hypertension was observed in 67.9% (n=76) of the patients, joint diseases in 55.4% (n=62), dyslipidemia in 40.2% (n=45), and diabetes type 2 in 27.7% (n=31). | 15946458 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Prior research has indicated an association between insulin resistance and stroke; we sought to determine if this association persists after adjusting for stroke risk factors, including glycemic control. | 15947493 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The results reinforce the importance of interventions to reduce physical inactivity, alcohol consumption, obesity and dyslipidemia, so as to prevent increasing incidence of diabetes. | 15947833 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus. | 15948897 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | Elevated ALT levels are associated with insulin resistance, and subjects with NAFLD have features of the metabolic syndrome that confer high-risk cardiovascular disease. | 15948897 |
| Nonalcoholic Steatohepatitis, Hypomagnesemia | Deregulated Nutrient Sensing | Hypomagnesemia, insulin resistance, and non-alcoholic steatohepatitis in obese subjects. | 15950075 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | As nonalcoholic steatohepatitis (NASH) seems to be related to insulin resistance, the aim of this study was to determine the potential relationship between DSML and NASH in obese subjects. | 15950075 |
| Non-insulin Hypoglycemic, Insulin Resistance, Diabetes Mellitus | Deregulated Nutrient Sensing | We compared obese individuals with the diagnosis of diabetes, insulin-resistance, and non-insulin resistance to a control group of non-obese, non-insulin-resistant subjects. | 15950075 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. | 15951550 |
| Fatty Liver, Fibrosis Assessment | Deregulated Nutrient Sensing | Logistic regression and multivariate regression analysis were used to identify variables independently associated with insulin resistance, fatty liver, and fibrosis. | 15951550 |
| Fatty degeneration | Deregulated Nutrient Sensing | Independent risk factors for steatosis were insulin resistance in genotype 1 patients (p = 0.001) and viral load in genotype 3 patients (p = 0.003). | 15951550 |
| Fatty degeneration | Deregulated Nutrient Sensing | Among genotype 1 patients, independent parameters associated with insulin resistance were age (p = 0.04) and steatosis (p = 0.004). | 15951550 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | This study shows that insulin resistance is the cause rather than the consequence of steatosis and fibrosis in genotype 1 patients and that increased circulating insulin is a risk factor for fibrosis through insulin resistance induced steatosis. | 15951550 |
| Kidney Failure, Chronic, insensitivity | Deregulated Nutrient Sensing | The CAPD treatment may lead to insulin insensitivity in non-diabetic end-stage renal disease patients and the high glucose content of CAPD solutions may be responsible for insulin resistance in CAPD patients. | 15951871 |
| Glucose Intolerance (disease), Beta-cell dysfunction | Deregulated Nutrient Sensing | In conclusion, elevated serum GGT levels predict glucose intolerance probably via insulin resistance rather than beta-cell dysfunction. | 15952086 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Association between insulin resistance and cholesteryl ester transfer protein gene polymorphism in type 2 diabetes mellitus]. | 15952120 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To study the association between cholesteryl ester transfer protein (CETP) gene polymorphism and insulin resistance in type 2 diabetes. | 15952120 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma lipids, fasting insulin, insulin sensitivity index and insulin resistance index were determined in 108 patients with type 2 diabetes. | 15952120 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It may be an important risk factor of insulin resistance in type 2 diabetes. | 15952120 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance in type 2 diabetes subjects was investigated before and 6 months after insulin administration in 43 type 2 diabetes patients (28 females and 15 males). | 15955377 |
| Weight Gain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, insulin treatment of type 2 diabetes patients leads to decrease in insulin resistance due to reduction in glucose toxicity and plasma atherogenicity despite weight gain. | 15955377 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Type 1 diabetes developed in a type 2 diabetic patient with severe insulin resistance. | 15955587 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We report a 38-year-old female with severe insulin resistance who developed type 1 diabetes after being diagnosed with type 2 diabetes. | 15955587 |
| Muscle Cramp | Deregulated Nutrient Sensing | Further, a hyperinsulinemic-euglycemic cramp study using an artificial pancreas showed that the patient had severe insulin resistance [glucose infusion rate 1.8 mg/(min kg); normal, 7.4+/-2.4 (mean+/-S.D.)]. | 15955587 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Guidelines for the management of dyslipidemia in patients with chronic kidney disease are based on results from the fasting lipid profile, which can be difficult to obtain from patients on an afternoon or night dialysis schedule. | 15957136 |
| Cardiac complication, Dyslipidemias, Hyperfibrinogenemia | Deregulated Nutrient Sensing | In peritoneally dialyzed patients glucose load into the peritoneum, dyslipidemia and hiperfibrinogenemia may further contribute at the cardiovascular complications. | 15962607 |
| Ovarian enlargement | Deregulated Nutrient Sensing | Ovarian enlargement is a constant feature of syndromes of extreme insulin resistance. | 15963065 |
| Lipodystrophy, Rabson-Mendenhall Syndrome, Syndrome | Deregulated Nutrient Sensing | Seven young patients with syndromes of extreme insulin resistance (five with lipodystrophy, one with Type B syndrome and one with Rabson-Mendenhall syndrome) were studied. | 15963065 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The objective was to determine whether systems of care implemented within a large medical group are associated with improved treatment and control of dyslipidemia in a high-risk group of coronary heart disease patients. | 15963307 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, MS gene | Deregulated Nutrient Sensing | In most cases, it is the hallmark of non-alcoholic fatty liver disease (NAFLD), a potentially progressive disease associated with insulin resistance and the metabolic syndrome (MS). | 15966506 |
| Hepatocellular necrosis | Deregulated Nutrient Sensing | We tested the hypothesis that insulin resistance per se might be associated with hepatocellular necrosis. | 15966506 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | We conclude that in obesity insulin resistance is a risk factor for raised liver enzyme levels, possibly related to NAFLD. | 15966506 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, diabetic | Deregulated Nutrient Sensing | Diabetes disappeared in 97% of diabetic subjects, blood pressure normalized in 53% of subjects with hypertension and serum lipid levels returned to normal in 88% of subjects with dyslipidemia. | 15970974 |
| Hyperglycemia | Deregulated Nutrient Sensing | A common variant in mitochondrial DNA (mtDNA) at bp 16189 (T-->C transition) has been associated with small birth size, adulthood hyperglycemia, and insulin resistance in Caucasians. | 15972579 |
| Increased insulin level | Deregulated Nutrient Sensing | This clustering is commonly associated with pre-diabetic hyperinsulinemia and it reflects peripheral insulin resistance. | 15977101 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In logistic regression analysis, NAFLD was associated with a percent FMV in the lower tertile (OR, 6.7; 95% CI, 1.26-36.1), after adjustment for age, sex, body mass index, and insulin resistance. | 15981216 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In type 2 diabetes, microalbuminuria is strongly related to insulin resistance. | 15983223 |
| Prediabetes syndrome, Atherosclerosis | Deregulated Nutrient Sensing | Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study. | 15983261 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated insulin resistance, blood pressure, and dyslipidemia (including small dense LDL) predicted incident diabetes. | 15983261 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We enrolled subjects with a diagnosis of type 2 diabetes (treated with diet alone or oral monotherapy) and dyslipidemia (not treated with any lipid-lowering agents). | 15983299 |
| Impaired mitochondrial function | Deregulated Nutrient Sensing | These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men. | 15983313 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The disease is determined by many risk factors such as age, gender, diabetes, dyslipidemia, smoking, as well as elevated serum levels of lipoprotein (a) (Lp(a)), homocysteine, C-reactive protein (CRP) and uric acid. | 15985286 |
| Dyslipidemias | Deregulated Nutrient Sensing | The interaction between thyroid function and insulin sensitivity is an important contributor to diabetic dyslipidemia and may justify T4 replacement in some patients. | 15985488 |
| Tumor necrosis | Deregulated Nutrient Sensing | Visceral adipose tissue and tumor necrosis factor alpha were the only predictors of calculated insulin resistance ( P < .05), explaining 43% of the variability. | 15988694 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Intact proinsulin is a marker for pancreatic beta-islet cell secretion status, and elevated levels indicate insulin resistance of type 2 diabetic patients with a high diagnostic specificity. | 15991797 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Our additional finding that intact proinsulin is stable in EDTA whole blood samples, which can be obtained from the routine.sample for HbA1c measurement, is increasing the probability of the acceptance of this marker for routine assessment of beta-cell dysfunction and insulin resistance in type 2 diabetes. | 15991797 |
| Thrombosis, Dyslipidemias | Deregulated Nutrient Sensing | High IL-6, TNF-alpha, and dyslipidemia are risk factors for thrombosis. | 15992611 |
| Dyslipidemias | Deregulated Nutrient Sensing | B+ patients showed increased HSP70-2, IL-6, IFN-gamma, TNF-alpha and dyslipidemia as compared to B- carriers. | 15992611 |
| Albuminuria | Deregulated Nutrient Sensing | The inclusion of albuminuria and insulin resistance by the WHO has made it the most discriminative criterion in identifying at risk individuals in all age groups. | 16005365 |
| Abnormal circulating valine concentration | Deregulated Nutrient Sensing | These results suggest that the predisposing metabolic abnormality in non-obese subjects with IGT alone or IFG alone and in progression to IFG+IGT might be deterioration of early phase insulin secretion, whereas insulin resistance might be the major contributory factor in obese subjects. | 16005368 |
| No metabolic abnormalities, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate the clinical characteristics and predisposing metabolic abnormalities in the development of glucose intolerance and diabetes mellitus in obese and non-obese Korean subjects. | 16005368 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Strategies to improve nutrition and to identify and treat cardiovascular risk factors such as dyslipidaemia and hypertension are urgently required. | 16005463 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, the C-allele has suggested to be linked to dyslipidemia. | 16005884 |
| Hyperlipidemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | To report a case of epidural lipomatosis in a patient with abnormal adipose tissue distribution, glucose intolerance and mixed hyperlipidemia. | 16007467 |
| Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance in cognitive impairment: the InCHIANTI study. | 16009759 |
| Impaired cognition | Deregulated Nutrient Sensing | To test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population. | 16009759 |
| Impaired cognition, Cerebrovascular accident | Deregulated Nutrient Sensing | The insulin resistance profile of patients in the CI/SF+ group was similar to that of individuals who had experienced stroke, whereas the profile of individuals with cognitive impairment without subcortical features (CI/SF- group) was similar to that of individuals in the no CI group. | 16009759 |
| Impaired cognition | Deregulated Nutrient Sensing | Cognitive impairment with but not without subcortical features is associated with biochemical and clinical features of insulin resistance syndrome. | 16009759 |
| Impaired cognition | Deregulated Nutrient Sensing | In epidemiologic populations, insulin resistance might contribute to cognitive impairment through a vascular mechanism. | 16009759 |
| Extrahepatic, Hepatitis C, Diabetes Mellitus, Non-Insulin-Dependent, Liver diseases | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) causes extrahepatic manifestations as well as liver diseases, and contributes to insulin resistance and type 2 diabetes mellitus. | 16012764 |
| Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance induces HCV infection, which causes an increase in the incidence of extrahepatic manifestations in HCV-infected individuals. | 16012764 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. | 16012940 |
| Dyslipidemias, Depression, CTCAE | Deregulated Nutrient Sensing | It is strongly associated with increasing age, dyslipidemia, and depression. | 16014053 |
| Dyslipidemias, Biliary calculi, Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | Increasing age, familial history of the disease, unhealthy lifestyle, overweight, dyslipidemia, type 2 diabetes and high plasma insulin levels are all associated with gallstones. | 16014208 |
| Inflammation, Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | These results suggest a possible role of subclinical inflammation in insulin resistance and glucose intolerance in Japanese, but it only partly explains the link between obesity and impaired glucose homeostasis. | 16020877 |
| Glucose Intolerance (disease), Behavior Disorders | Deregulated Nutrient Sensing | The findings are consistent with an inverse linear relation between a cluster of core protective, lifestyle-related factors and the prevalence of both glucose intolerance and insulin resistance. | 16026378 |
| Obesity | Deregulated Nutrient Sensing | Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005). | 16029943 |
| Prostate carcinoma | Deregulated Nutrient Sensing | These results suggest that genetic variants in the DNA repair pathways may be involved in prostate cancer etiology and that other risk factors, including preserved foods and insulin resistance, may modulate prostate cancer risk in combination with genetic susceptibility in these repair pathways. | 16030105 |
| Congestive heart failure | Deregulated Nutrient Sensing | Insulin resistance and risk of congestive heart failure. | 16030278 |
| Diabetes Mellitus, Obesity, Congestive heart failure | Deregulated Nutrient Sensing | Diabetes and obesity are established risk factors for congestive heart failure (CHF) and are both associated with insulin resistance. | 16030278 |
| Obesity, Congestive heart failure | Deregulated Nutrient Sensing | To explore if insulin resistance may predict CHF and may provide the link between obesity and CHF. | 16030278 |
| Congestive heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance predicted CHF incidence independently of established risk factors including diabetes in our large community-based sample of elderly men. | 16030278 |
| Obesity, Congestive heart failure | Deregulated Nutrient Sensing | The previously described association between obesity and subsequent CHF may be mediated largely by insulin resistance. | 16030278 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Immune gene variants in man and in animal models were found to affect insulin resistance and diabetes incidence. | 16032528 |
| Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Leptin might have a beneficial effect on CHD in type 2 diabetes, probably by counteracting the effect of insulin-like molecules or insulin resistance. | 16038995 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | Cigarette smoking is associated with increased insulin resistance and other metabolic abnormalities. | 16039294 |
| Dyslipidemias, Depressed mood | Deregulated Nutrient Sensing | On the other hand, dyslipidemia was less common in patients with depressed LV function (35.4% vs. 56.9%, p = 0.01). | 16041968 |
| Dyslipidemias, Diabetes Mellitus, physiopathological, Impaired | Deregulated Nutrient Sensing | After adjustment for ST-elevation location and number of vessels with critical stenosis, diabetes and smoking were associated with a significantly higher risk of LVEF impairment (diabetes: OR = 3.73, 95% CI 1.25-11.16; smoking: OR = 3.9, 95% CI 1.37-11.07) and dyslipidemia with a significantly lower risk of LV dysfunction (OR: 0.37, 95% CI 0.15-0.88). | 16041968 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Administration of DHEA to rats and mice reduces visceral fat accumulation, and improves insulin resistance in experimental models of diet-induced obesity and/or Type 2 diabetes. | 16042365 |
| palladium, Malnutrition, Dyslipidemias, peritoneal | Deregulated Nutrient Sensing | The high Levels of glucose, glucose degradation products (GDPs), and lactate buffer present in standard peritoneal dialysis (PD) solutions contribute to peritoneal damage, malnutrition, and dyslipidemia. | 16048260 |
| Cholelithiasis, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance is a risk factors for non-alcoholic fatty liver disease (NAFLD) and for gallstone disease (GD). | 16048564 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance has been proposed as an important risk factor in the development of atherosclerosis. | 16050951 |
| Coronary Stenosis | Deregulated Nutrient Sensing | These results suggest that insulin resistance may play a major role in the development of diffuse coronary artery stenosis. | 16050951 |
| Inflammation | Deregulated Nutrient Sensing | Knowledge of the factors which simultaneously contribute to insulin-resistance-related inflammation may contribute to early therapeutic targeting. | 16052331 |
| Atherosclerosis | Deregulated Nutrient Sensing | IL-18 has recently been described as one of the factors which, in addition to insulin resistance, may also contribute to atherosclerosis. | 16052331 |
| Turner Syndrome, Pseudohermaphroditism | Deregulated Nutrient Sensing | Female pseudohermaphroditism due to classical 21-hydroxylase deficiency and insulin resistance in a girl with Turner syndrome. | 16052861 |
| Hyperandrogenism | Deregulated Nutrient Sensing | Improvement in insulin resistance after treatment of hyperandrogenism has not been previously reported. | 16052861 |
| Diastolic dysfunction, Hypertension, CTCAE, Hypertrophy | Deregulated Nutrient Sensing | Left ventricular (LV) hypertrophy and diastolic dysfunction, which are common cardiac consequences of hypertension, are modified by insulin resistance. | 16053992 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The present study assessed the hypothesis that primary treatment of insulin resistance may reverse such cardiac changes in hypertensive patients. | 16053992 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The present findings demonstrate that pioglitazone improves LV diastolic function without LV mass regression in hypertensive patients in proportion to the amelioration of insulin resistance. | 16053992 |
| Inflammation, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hemodialysis (HD) patients often experience cardiovascular events, that might be related to altered calcium-phosphate metabolism, dyslipidemia, and chronic inflammation in addition to hypertension. | 16060120 |
| Inflammation, Hyperparathyroidism, Anemia | Deregulated Nutrient Sensing | The prevalence of insulin resistance and its relationship between anemia, secondary hyperparathyroidism, inflammation, and cardiac parameters in chronic hemodialysis patients. | 16060127 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Insulin resistance (IR) frequently accompanies end-stage renal disease (ESRD). | 16060127 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Because insulin resistance is an independent risk factor of cardiovascular mortality in ESRD patients, it was accepted that being able to correct the insulin resistance could be a novel therapeutic approach in this cohort. | 16060127 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance play a major role in the development of liver steatosis (LS), but also relative leptin resistance has been reported to correlate with LS in humans. | 16061835 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance and carotid atherosclerosis in 221 patients with potential hyperglycemia. | 16075748 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | To investigate the relationship between insulin resistance and carotid atherosclerosis in patients with potential hyperglycemia. | 16075748 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Having diabetes (HR 0.86; 95% CI 0.79 to 0.94) and dyslipidemia (HR 0.71; 95% CI 0.66 to 0.76) increased the rate of persistence. | 16076920 |
| Coronary heart disease | Deregulated Nutrient Sensing | Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women. | 16076942 |
| Vascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | It is premature to consider adiponectin as a root for vascular disease in women despite its association with insulin resistance and diabetes. | 16076942 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Overweight Hispanic children with a family history of type 2 diabetes may represent a unique population given that pubertal insulin resistance was not evident once analyses controlled for body composition. | 16077712 |
| Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | Traditional cardiovascular risk factors such as central obesity, high blood pressure and insulin resistance, all constituents of metabolic syndrome, have been associated with increased levels of C-reactive protein (CRP). | 16077717 |
| Obesity | Deregulated Nutrient Sensing | Serum resistin is not associated with obesity or insulin resistance in humans. | 16080635 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Resistin has proposed link with obesity related insulin resistance and type 2 diabetes. | 16080635 |
| Obesity | Deregulated Nutrient Sensing | It is suggested that circulating resistin levels are not associated with obesity or insulin resistance in humans. | 16080635 |
| Restenosis | Deregulated Nutrient Sensing | Insulin resistance as a predictor for restenosis after coronary stenting. | 16080969 |
| Restenosis | Deregulated Nutrient Sensing | The rationale of this study was to determine whether insulin resistance is an independent risk factor for restenosis after coronary stenting. | 16080969 |
| Restenosis | Deregulated Nutrient Sensing | However, it has not been determined whether insulin resistance is independently related to restenosis after coronary stenting. | 16080969 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Restenosis was influenced by insulin resistance [Relative Risk (RR) 2.06; 95 percent confidence interval (95%CI) 1.20 to 3.56], diabetes mellitus (DM: RR 1.92; 95%CI 1.25 to 2.95), and final minimal lumen diameter (RR 2.83; 95%CI 1.32 to 6.06). | 16080969 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Dysfunction in mitochondrial oxidative phosphorylation plays a central role in insulin resistance and type 2 diabetes. | 16082529 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Further surveillance in this population is essential in verifying the impact of dyslipidemia as a risk of cardiovascular disease in rural Thai adults. | 16083223 |
| Acute myocardial infarction, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Left ventricular diastolic function in normotensive subjects 2 months after acute myocardial infarction is related to glucose intolerance. | 16084165 |
| Glucose Intolerance (disease), Electrocardiogram: myocardial infarction (finding), Ventricular Dysfunction, Left | Deregulated Nutrient Sensing | Both glucose intolerance and myocardial infarction are independently associated with impaired left ventricular (LV) function. | 16084165 |
| Hyperglycemia, Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | Independent of LVEF, the pattern of abnormal LV filling in normotensive subjects 2 months after AMI is a function of the severity of glucose intolerance, restrictive in the majority of the diabetic patients and nonrestrictive in the majority of the euglycemic patients, impaired glucose tolerance, and stress hyperglycemia. | 16084165 |
| Demographics Domain, Cardiovascular Diseases, Refractory anemias, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Frequencies of risk factors among the RA patients compared with controls were hypertension (28% versus 32%), smoking (37% versus 29%), dyslipidemia (23% versus 25%), diabetes mellitus (DM) (14% versus 14%), and family history of cardiovascular disease (CVD) (4% versus 7%). | 16084220 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Both the MetS and insulin resistance are strong and mutually independent predictors of vascular risk among angiographed coronary patients. | 16091486 |
| Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Selenium as a component of glutathione peroxidase may be beneficial in insulin resistance, hence potentially may modify the risk of diabetes and cardiovascular disease (CVD). | 16093402 |
| palladium, Dyslipidemias, Mental disorders | Deregulated Nutrient Sensing | Dyslipidemia, psychological disorders and presence of at least 1 risk factor were significantly associated with PD. | 16094040 |
| Cryoglobulinemia, Dyslipidemias | Deregulated Nutrient Sensing | Prednisone administration was effective in classical cryoglobulinaemia symptoms and also in dyslipidaemia. | 16095015 |
| Fatty Liver, Hyperglycemia, Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | The abnormal rates for conventional IHD risk factors including hypertension, dyslipidemia, hyperglycemia and overweight increased in accordance with the severity of fatty liver. | 16097054 |
| Nonalcoholic Steatohepatitis | Deregulated Nutrient Sensing | Insulin resistance and oxidative stress induced by products of small intestinal bacterial activity are putative factors in the pathogenesis of non-alcoholic steatohepatitis. | 16097995 |
| Hypoglycemia | Deregulated Nutrient Sensing | Therefore, we suspected that she had reactive hypoglycemia associated with insulin resistance and treated her with 15 mg/day pioglitazone. | 16098929 |
| Hypoglycemia | Deregulated Nutrient Sensing | Thus, we believe that pioglitazone is effective for reactive hypoglycemia and aggravated glycemic metabolism associated with insulin resistance. | 16098929 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Nephrolithiasis | Deregulated Nutrient Sensing | Insulin resistance is a central feature of type 2 diabetes mellitus (DM) and may increase the risk of kidney stone formation. | 16105055 |
| Kidney Calculi | Deregulated Nutrient Sensing | Because insulin resistance can precede the diagnosis of DM by decades, we also prospectively examined the relation between kidney stones and the diagnosis of incident DM. | 16105055 |
| Glucose Intolerance (disease), Coronary heart disease | Deregulated Nutrient Sensing | Glucose intolerance is associated with C-reactive protein and intima-media anatomy of the common carotid artery in patients with coronary heart disease. | 16108851 |
| Glucose Intolerance (disease), Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance was associated with hs-CRP and cIMa in patients with coronary heart disease without known diabetes mellitus. | 16108851 |
| Dyslipidemias, Dysglycemia | Deregulated Nutrient Sensing | Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. | 16109522 |
| Muscular Atrophy, Cerebrovascular accident, Diabetes Mellitus | Deregulated Nutrient Sensing | Stroke patients have gross muscular atrophy and high prevalence of diabetes and insulin resistance. | 16109906 |
| Dyslipidemias, Antihypertensive Agents, Obesity | Deregulated Nutrient Sensing | Prevalence of obesity and dyslipidaemia in hypertensives seen in Abuja, Nigeria. | 16112955 |
| Dyslipidemias, Hypertension, CTCAE, Antihypertensive Agents, Obesity | Deregulated Nutrient Sensing | This is a report of observations on a hospital-based study over the prevalence of obesity and dyslipidaemia seen in hypertensives attending our hypertension clinic. | 16112955 |
| Vascular Diseases, Metabolic Syndrome X, Atherosclerosis, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases. | 16117820 |
| Alopecia | Deregulated Nutrient Sensing | We hypothesized that not only the mental aspects but also certain physical aspect of women's health, such as insulin resistance, have an important role in the determination of HRQOL among women with hair loss. | 16120206 |
| Alopecia | Deregulated Nutrient Sensing | Furthermore, the prevalence rates of IGR and insulin resistance measured by QUICKI were higher among the women with hair loss than those with normal hair. | 16120206 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | The use of Achilles tendon sonography to distinguish familial hypercholesterolemia from other genetic dyslipidemias. | 16123315 |
| Dyslipidemias | Deregulated Nutrient Sensing | Sonographic AT characteristics are normal in non-FH dyslipidemias. | 16123315 |
| Italy | Deregulated Nutrient Sensing | The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. | 16123373 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2 diabetes. | 16123373 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance. | 16123373 |
| diabetic | Deregulated Nutrient Sensing | We here report that the prevalent TRB3 missense Q84R polymorphism is significantly (P < 0.05) associated with several insulin resistance-related abnormalities in two independent cohorts (n = 178 and n = 605) of nondiabetic individuals and with the presence of a cluster of insulin resistance-related cardiovascular risk factors in 716 type 2 diabetic patients (OR 3.1 [95% CI 1.2-8.2], P = 0.02). | 16123373 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Despite the presence of severe insulin resistance, the patient did not develop overt diabetes mellitus at the time of investigation. | 16127220 |
| Glucose Intolerance (disease), Colorectal Carcinoma | Deregulated Nutrient Sensing | Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People. | 16127231 |
| Glucose Intolerance (disease), Colorectal Carcinoma | Deregulated Nutrient Sensing | Glucose intolerance may increase the risk of developing colorectal cancer. | 16127231 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | SOD and GPx activities and TAS were lower in men with advanced coronary atherosclerosis that in age-matched clinically healthy men with similar dyslipidemia and were even further decreased compared with clinically healthy men without dyslipidemia. | 16127364 |
| insulinoma, NEUROD1 wt Allele | Deregulated Nutrient Sensing | NIDDM is characterized by progressive insulin resistance and the failure of insulin-producing pancreatic beta cells to compensate for this resistance. | 16127460 |
| Increased insulin level, Inflammation | Deregulated Nutrient Sensing | Hyperinsulinemia, inflammation, and prolonged activation of the insulin receptor (INSR) have been shown to induce insulin resistance by decreasing INSR substrate (IRS) protein levels. | 16127460 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Characteristics of type 2 diabetes in terms of insulin resistance in Korea. | 16127772 |
| diabetic | Deregulated Nutrient Sensing | The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. | 16127772 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. | 16127772 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients. | 16127772 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Twenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance. | 16127779 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. | 16129690 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a primary characteristic of type 2 diabetes and likely causally related to the pathogenesis of the disease. | 16129690 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Inhibition of serine 307 phosphorylation by rapamycin mimicked type 2 diabetes and reduced the sensitivity of IRS1 tyrosine phosphorylation in response to insulin, while stimulation of the phosphorylation by okadaic acid, in cells from patients with type 2 diabetes, rescued cells from insulin resistance. | 16129690 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings identify a molecular mechanism for insulin resistance in non-selected patients with type 2 diabetes. | 16129690 |
| Glucose Intolerance (disease), Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The features of the MS were characterized as five factors (obesity, dyslipidemia, elevated blood pressure, glucose intolerance, and insulin resistance), which were combined to create an MS summary score. | 16129731 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Basing on above mentioned results it may be concluded that essential hypertension (especially if complicated with dyslipidemia) impairs fibrinolysis, what might be related to renin-angiotensin system activation in lipid metabolism disorders. | 16130596 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding TNF-alpha (TNF) has shown inconsistent associations with susceptibility to both conditions. | 16132956 |
| diabetic | Deregulated Nutrient Sensing | Using Homa and modified Homa formula to evaluate the insulin resistance and islet beta cell function both in the normal and diabetic subjects was similar. | 16134594 |
| Colorectal Carcinoma, Colitis | Deregulated Nutrient Sensing | A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation. | 16136044 |
| Carcinogenesis, Colorectal Carcinoma, Colitis | Deregulated Nutrient Sensing | Colorectal cancer risk is associated with biochemical markers for B-vitamin deficiency, insulin resistance and colonic inflammation, suggesting that these three conditions are each involved in colon carcinogenesis. | 16136044 |
| Colitis | Deregulated Nutrient Sensing | Our supplemental strategy modestly affected some of the biomarkers associated with folate metabolism and insulin resistance, but had no effect on those associated with colonic inflammation. | 16136044 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Effect of jiang zhuo mixture on blood glucose level and insulin resistance in diabetes. | 16136948 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | The role of intact proinsulin and adiponectin in endothelial dysfunction and insulin resistance has been receiving increasing attention. | 16138267 |
| diabetic | Deregulated Nutrient Sensing | Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients. | 16140413 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Interleukin-6 (IL-6), a powerful inflammatory mediator, plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. | 16140413 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings highlight that IL-6-174 G > C polymorphism affects insulin resistance in type 2 diabetes, where C+ carriers have an insulin resistance "IL-6-sensitive", while C- carriers do not. | 16140413 |
| diabetic | Deregulated Nutrient Sensing | The identification of two categories of diabetic patients may, therefore, lead to different therapeutic strategies in the management of insulin resistance. | 16140413 |
| Diabetic Nephropathy, Tumor necrosis, Obesity | Deregulated Nutrient Sensing | The G-308A polymorphism in the promoter region of the tumor necrosis factor alpha (TNF-alpha) gene has been reported to be associated with insulin resistance and obesity, both of which may increase the risk of diabetic nephropathy. | 16141456 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus was defined as glucose intolerance either treated dietary, with oral hypoglycemics or with insulin. | 16142517 |
| Apolipoprotein E, Dyslipidemias | Deregulated Nutrient Sensing | Apolipoprotein E polymorphism is an important genetic marker for dyslipidemia. | 16142566 |
| Fatty Liver | Deregulated Nutrient Sensing | TNFalpha induces insulin resistance and promoter polymorphisms of TNFalpha gene affect the release of this cytokine, implicated in the pathogenesis of HCV-related diabetes and fatty liver. | 16143422 |
| Liver damage, Fatty degeneration | Deregulated Nutrient Sensing | TNFalpha pathway activity was correlated with LDL cholesterol, steatosis, and insulin resistance, which, in turn, was correlated with the severity of liver damage. | 16143422 |
| Inflammation | Deregulated Nutrient Sensing | Furthermore, it may be involved in regulative processes taking place in insulin resistance and inflammation. | 16144855 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, and not sex hormones or insulin resistance affects left ventricular mass in aging men. | 16145986 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin. | 16150198 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | To explore the correlation of nonalcoholic fatty liver (NAFL) with insulin resistance and the intervention of it by Gankangyin(GKY). | 16150198 |
| Burn Specimen Source Codes, Acinetobacter, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Acinetobacter infection is associated with acquired glucose intolerance in burn patients. | 16151285 |
| Burn Specimen Source Codes, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | was associated with the acquisition of glucose intolerance in burn patients. | 16151285 |
| Communicable Diseases, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | infection were 9.8 times more likely to develop glucose intolerance than those without the infection (P < .0001). | 16151285 |
| Communicable Diseases, Burn Specimen Source Codes, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | infection, 47% had glucose intolerance, compared with 12% in those with infection of the burn only (P = .03). | 16151285 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Statins have been shown to significantly reduce morbidity and mortality both in patients with coronary artery disease and in those with dyslipidemia when they are taken regularly. | 16151763 |
| Tumor necrosis, diabetic | Deregulated Nutrient Sensing | Three measures of tumor necrosis factor alpha activity and insulin resistance in nonobese Japanese type 2 diabetic patients. | 16154427 |
| diabetic | Deregulated Nutrient Sensing | In contrast, insulin resistance was not associated with TNF-alpha, nor sTNF-R (sTNF-R1 and sTNF-R2) in our diabetic patients. | 16154427 |
| diabetic | Deregulated Nutrient Sensing | From these results, it can be concluded that peripheral levels of TNF-alpha system activity are not a major factor responsible for insulin resistance in nonobese Japanese type 2 diabetic patients. | 16154427 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. | 16156880 |
| Dyslipidemias, Diabetes Mellitus, Smoking, Atherosclerosis | Deregulated Nutrient Sensing | Smoking, dyslipidemia, diabetes, and age were all found to increase the degree of atherosclerosis (p < 0.01 to 0.05). | 16162761 |
| Dyslipidemias | Deregulated Nutrient Sensing | Treatment with high-dose simvastatin reduces secretion of apolipoprotein B-lipoproteins in patients with diabetic dyslipidemia. | 16162940 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | HMG-CoA reductase inhibitors (statins) are effective lipid-altering drugs for the treatment of dyslipidemia in patients with type 2 diabetes mellitus. | 16162940 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Mean age of the patients enrolled was 64 +/- 12 years; 69% are men, 26% have diabetes, 79% have dyslipidemia, and 72% have coronary artery disease (CAD) > or = 50%. | 16169331 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. | 16170353 |
| Carcinoma of lung, Breast Carcinoma | Deregulated Nutrient Sensing | Here, we show that Sirt1 inhibitor, Sirtinol, induced senescence-like growth arrest characterized by induction of senescence-associated beta-galactosidase activity and increased expression of plasminogen activator inhibitor 1 in human breast cancer MCF-7 cells and lung cancer H1299 cells. | 16170353 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Data on the effects of OSAS treatment with continuous positive airway pressure (CPAP) on blood glucose and insulin resistance are conflicting. | 16171273 |
| Dyslipidemias, Coronary Artery Disease, Peripheral Vascular Diseases, Autonomic neuropathy, Hypertension, CTCAE | Deregulated Nutrient Sensing | Serum C-peptide level was higher in patients with dyslipidemia (p = 0.045), hypertension (p = 0.001), coronary artery disease (p = 0.001), peripheral vascular disease (p = 0.001) and autonomic neuropathy (p = 0.001). | 16173326 |
| Lipodystrophy, Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Patient 2 was a 24-yr-old Caucasian female with generalized lipodystrophy, hypertriglyceridemia, and severe insulin resistance diabetes who required more than 200 U of insulin daily. | 16174718 |
| Apolipoprotein E, Dyslipidemias | Deregulated Nutrient Sensing | The objective of this work was to study the distribution of apolipoprotein E (APOE) genotypes in a sample of the Portuguese population, and its association with the dyslipidemias observed. | 16176168 |
| Atherosclerosis | Deregulated Nutrient Sensing | Plasma adiponectin is associated with insulin resistance and atherosclerosis. | 16179286 |
| Hyperlipidemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Plasma lipids were measured in 17 subjects, 16 of whom had hyperlipidemia and 14 presented with either documented insulin resistance or diabetes mellitus. | 16181372 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology. | 16186174 |
| Non-insulin Hypoglycemic, "Alzheimers Disease", Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | The goal of this study was to further explore potential mechanisms through which diabetogenic dietary conditions that result in promotion of insulin resistance (IR), a feature of non-insulin dependant diabetes mellitus (type-2 diabetes), may influence Alzheimer's disease (AD). | 16186174 |
| GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | ACS was associated with insulin resistance and increased levels of specific insulin, proinsulin, and high proinsulin-to-insulin ratios. | 16186285 |
| Obesity | Deregulated Nutrient Sensing | In stratified analyses, this CRP-diabetes association was stronger in subjects without obesity or other risk factors related to insulin resistance and in nondrinking subjects. | 16186286 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Our findings suggest that elevated CRP concentration is a significant predictor of diabetes in the general Japanese population, independent of obesity and insulin resistance. | 16186286 |
| Choline Dehydrogenase, Mitochondrial, Hypertriglyceridemia, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Dyslipidemia contributes significantly to CHD in diabetic patients, in whom lipid abnormalities include hypertriglyceridemia, low HDL cholesterol, and increased levels of small, dense LDL particles. | 16186406 |
| Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction. | 16186408 |
| Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). | 16186408 |
| Vertigo, Peripheral, Tinnitus, Dyslipidemias, Depression, CTCAE, Hypertension, CTCAE | Deregulated Nutrient Sensing | In multivariable analysis, only female sex, self-reported depression, tinnitus, hypertension, and dyslipidemia had an independent effect on vestibular vertigo. | 16186531 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | No comparable associations were found with other traits of the insulin-resistance syndrome (e. g.; body mass index, waist to hip ratio). | 16189801 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To present a retrospective analysis of the effects of human U-500 insulin in 20 patients with type 2 diabetes and insulin resistance. | 16191489 |
| Nonalcoholic Steatohepatitis, Prostate Cancer Outcomes Study, Weight decreased, Polycystic Ovary Syndrome, Fatty Liver Disease | Deregulated Nutrient Sensing | To report a case of biopsy-documented nonalcoholic steatohepatitis (NASH), which improved appreciably through moderate exercise and weight loss in a young woman with polycystic ovary syndrome (PCOS) and insulin resistance. | 16191492 |
| Prostate Cancer Outcomes Study, Fatty Liver Disease | Deregulated Nutrient Sensing | In addition, we review the recent literature regarding the association of insulin resistance with NASH and PCOS. | 16191492 |
| Hyperlipidemia, dysmetabolic syndrome, Prostate Cancer Outcomes Study, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Women with PCOS and insulin resistance have an increased risk of developing many of the consequences of the dysmetabolic syndrome, including type 2 diabetes, hypertension, and hyperlipidemia. | 16191492 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. | 16192263 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obese people are at high risk for developing diabetes, dyslipidemia, hypertension, and cardiovascular diseases, which lead to an increased risk of mortality. | 16194025 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity was found in 56%, hypertension in 29%, dyslipidemia in 54%, diabetes in 24%, smoking history in 82%, and habitual physical activity in 13% in young patients. | 16195612 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptors (PPARs) present a therapeutic target, and simultaneous activation of PPAR-alpha and PPAR-gamma may provide improvements in glycemic control and dyslipidemia in patients with type 2 diabetes. | 16199244 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | In a predominantly low income population and without continuous assistance from the State to purchase statins, the achievement of preconized objectives for LDL-cholesterol, by 3rd Guidelines on Dyslipidemia of Brasilian Society of Cardiology, is low and also significantly lower among very old patients, with a high risk profile for atherosclerosis. | 16200261 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular Disease and a family history of dyslipidemia were present in 55 & 60% of the samples, respectively. | 16205024 |
| Dyslipidemias, Family history | Deregulated Nutrient Sensing | A family history of dyslipidemia, an elevated LDL-C level, and a high FH score exhibited a statistically significant association with mutations. | 16205024 |
| Dyslipidemias, Family history | Deregulated Nutrient Sensing | LDL-R gene mutation was significantly associated with family history of dyslipidemia, LDL-C Level and FH score. | 16205024 |
| Glucose Intolerance (disease), Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | Deceleration time was shortened with a worsening degree of glucose intolerance in all the patients (P=0.0005), in those with left ventricular hypertrophy (P=0.0006) and in those without left ventricular hypertrophy (P=0.033). | 16205440 |
| Hypertensive (finding), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In hypertensive patients, left ventricular diastolic function is determined by left ventricular mass index and the status of preclinical glucose intolerance, independent of age, gender, race, body mass index, blood pressure level, nocturnal drop in blood pressure or lipid level. | 16205440 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Influence of glucose control and improvement of insulin resistance on microvascular blood flow and endothelial function in patients with diabetes mellitus type 2. | 16207627 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | The significant association of severe obesity in nondiabetic and normotensive patients suggests that other obesity-associated mechanisms such as insulin resistance and inflammation should be further explored. | 16209988 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia among black patients with type 2 diabetes. | 16211122 |
| Dyslipidemias | Deregulated Nutrient Sensing | The total number of patients with diabetic dyslipidaemia (DD) was 56 (90.3%). | 16211122 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Longer TV viewing (>14 h per week) was associated with an increased risk of insulin resistance, obesity and dyslipidaemia in both men and women. | 16211373 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum resistin, adiposity and insulin resistance in Saudi women with type 2 diabetes mellitus. | 16212119 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Recently a unique signaling molecule, resistin, has been proposed as playing a role in the pathogenesis of obesity-related insulin resistance, but its relevance to human diabetes remains uncertain. | 16212119 |
| Overweight, diabetic | Deregulated Nutrient Sensing | Therefore, we assessed the relationship between serum resistin concentrations and insulin resistance in lean, overweight and obese (OW/OB) non-diabetic and diabetic Saudi women. | 16212119 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Resistin concentrations are elevated in patients with type 2 diabetes and are associated with obesity and insulin resistance. | 16212119 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | A case control study was conducted within the prospective cohort of the Insulin Resistance Atherosclerosis Study: 26 cases who developed type 2 diabetes in the follow-up period and 26 controls who remained free of type 2 diabetes were randomly selected. | 16222068 |
| diabetic | Deregulated Nutrient Sensing | Stepwise regression analyses showed that body mass index or insulin resistance index was the major factor determining plasma esRAGE in all, nondiabetic or diabetic population. | 16224056 |
| Tuberous xanthoma, Dyslipidemias | Deregulated Nutrient Sensing | He subsequently developed refractory dyslipidemia, palmar crease, and tuberous xanthomas. | 16227109 |
| Acute myocardial infarction, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance is associated with a high incidence of left ventricular (LV) dysfunction after acute myocardial infarction (AMI). | 16229911 |
| Autonomic neuropathy, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients with SMI were older and had a higher prevalence of autonomic neuropathy, hypertension, and dyslipidemia than those without. | 16230776 |
| diabetic | Deregulated Nutrient Sensing | Impaired nonoxidative glucose disposal and decrease in mitochondrial glucose oxidation both contribute to insulin resistance in diabetic subjects. | 16234307 |
| Proteinuria, Edema, Diabetic Retinopathy, Glucose Intolerance (disease), Chronic Kidney Diseases | Deregulated Nutrient Sensing | Here, we present three patients with edema, heavy proteinuria, chronic renal failure, in whom no past or present symptomatic glucose intolerance or diabetic retinopathy were found. | 16240902 |
| Dyslipidemias, Kidney Diseases, Obesity | Deregulated Nutrient Sensing | Specific population characteristics (high prevalences of central obesity, dyslipidaemia, renal disease) may make the WHO definition preferable to the ATPIII definition in these population groups. | 16241926 |
| LMNA wt Allele, Dyslipidemias | Deregulated Nutrient Sensing | This case demonstrates the benefits of PPARgamma-agonists on glycaemic control and dyslipidaemia in a patient with FPLD. | 16241930 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | For non-diabetic men and women, the body size factor (body size/insulin resistance factor for men) was strongly associated with diabetes incidence (OR=2.30, 95% CI 1.41-3.74 and OR=2.06, 95% CI 1.33-3.17, respectively). | 16242698 |
| Coronary heart disease | Deregulated Nutrient Sensing | Cross-sectional associations of resistin, coronary heart disease, and insulin resistance. | 16249281 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Metabolic syndrome may not capture all the CVD risk associated with insulin resistance. | 16249452 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Free fatty acids are associated with obesity, insulin resistance, and atherosclerosis in renal transplant recipients. | 16249742 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance (IR) may be implicated in the pathogenesis of atherosclerosis in renal transplant recipients (RTRs) and be contributed to, in part, by free fatty acids (FFAs), produced in excess in centrally obese individuals. | 16249742 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Our data indicate that young asymptomatic male smokers tend to have hypertension, dyslipidaemia and increased production of free oxygen radicals, perhaps by attenuation of oxidative stress by cigarette smoking. | 16251776 |
| Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Epidemiological studies suggest that dyslipidemia is an independent risk factor for the development of renal insufficiency in otherwise healthy individuals. | 16253720 |
| Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | This study suggests that arterial changes occur early in the course of renal disease progression and may be related to dyslipidemia in the early stages. | 16253725 |
| Dyslipidemias, Depressed mood, Hepatomegaly | Deregulated Nutrient Sensing | CESD patients present in childhood with hepatomegaly and dyslipidemia characterized by elevated total and low-density lipoprotein cholesterol (LDL-C), with elevated triglycerides and depressed high-density lipoprotein cholesterol (HDL-C). | 16255772 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Changing relationships of obesity and dyslipidemia in Greek children: 1982-2002. | 16256184 |
| Obesity | Deregulated Nutrient Sensing | ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. | 16261187 |
| Inflammation, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Inflammation in adipose tissue may link obesity to insulin resistance and atherosclerosis. | 16261187 |
| Obesity | Deregulated Nutrient Sensing | We investigated ALOX5AP expression in adipose tissue, and association of gene polymorphisms with obesity and insulin resistance. | 16261187 |
| Obesity | Deregulated Nutrient Sensing | ALOX5AP haplotypes that associate with CVD are not associated with obesity or insulin resistance. | 16261187 |
| Obesity | Deregulated Nutrient Sensing | Investigated ALOX5AP haplotypes are not major primary risk factors for obesity and insulin resistance. | 16261187 |
| Dyslipidemias, Breast Carcinoma, Obesity | Deregulated Nutrient Sensing | High levels of serum insulin and obesity often coexist with dyslipidemia in the insulin resistance syndrome (IRS), but the contribution of lipids to breast cancer outcome is unclear. | 16261412 |
| AIRE wt Allele, Addison Disease, Hypothyroidism, Glucose Intolerance (disease), Hypoparathyroidism | Deregulated Nutrient Sensing | APECED was suspected first because she developed progressively hypoparathyroidism, adrenocortical failure, glucose intolerance, and hypothyroidism. | 16263818 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | To study the difference in prevalence of dyslipidemia, hypercholesterolemia, hypertriglyceridemia and low blood high-density lipoprotein cholesterol (HDL-C) between the residents of urban and rural areas of varied regions in China. | 16266538 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia has become one of important risk factors threatening health of Chinese people, with hypertriglyceridemia and low blood HDL-C as two major types in those aged 18 and over. | 16266538 |
| Dyslipidemias | Deregulated Nutrient Sensing | It is very important to pay more attention to earlier comprehensive prevention and control of dyslipidemia. | 16266538 |
| Neoplasms | Deregulated Nutrient Sensing | Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. | 16269335 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Inactivation of HIC1 results in upregulated SIRT1 expression in normal or cancer cells; this deacetylates and inactivates p53, allowing cells to bypass apoptosis and survive DNA damage. | 16269335 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Since aging increases promoter hypermethylation and epigenetic silencing of HIC1, we speculate that the resultant upregulation of SIRT1 may be a double-edged sword that both promotes survival of aging cells and increases cancer risk in mammals. | 16269335 |
| Autosomal Recessive Disorder, Myeloid Leukemia, Chronic, Familial generalized lipodystrophy | Deregulated Nutrient Sensing | Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near complete absence of adipose tissue since birth and insulin resistance. | 16269843 |
| Hypertension, CTCAE, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Recent changes in lifestyle and diet of Alaskan Eskimos, leading to obesity, hypertension, insulin resistance and DM, contribute to an increased risk for cardiovascular disease. | 16277121 |
| Glucose Intolerance (disease), Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | CHD was significantly related to age, glucose intolerance and insulin. | 16277121 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | This finding suggests that high consumption of C20-C22 omega-3 FAs protects against the development of the MS and glucose intolerance. | 16277123 |
| Periodontal Diseases, Obesity | Deregulated Nutrient Sensing | Obesity is a significant predictor of periodontal disease and insulin resistance appears to mediate this relationship. | 16277579 |
| Periodontal Diseases, Obesity | Deregulated Nutrient Sensing | Furthermore, obesity is associated with high plasma levels of TNFalpha and its soluble receptors, which in turn may lead to a hyperinflammatory state increasing the risk for periodontal disease and also accounting in part for insulin resistance. | 16277579 |
| Periodontal Diseases, Periodontal Infection, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Further studies of the molecular basis of insulin resistance and its relationship to diabetes, periodontal disease, and obesity are necessary to fully test the hypothesis that adipocyte production of proinflammatory cytokines is a pathogenic factor linking obesity to diabetes and periodontal infections. | 16277579 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prescreening tools for diabetes and obesity-associated dyslipidaemia: comparing BMI, waist and waist hip ratio. | 16278693 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In men, BMI had a nonsignificantly higher sensitivity than waist or WHR for both diabetes and dyslipidaemia (77 vs 74 and 66% P<0.3, 0.09; 56 vs 54 and 49% P<0.5, 0.16). | 16278693 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol. | 16280425 |
| Alzheimers Disease", Data types - Address, Memory impairment | Deregulated Nutrient Sensing | Insulin resistance (impaired insulin action) has been associated with Alzheimer disease (AD) and memory impairment, independent of AD. | 16286438 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | In this large prospective cohort, atherogenic dyslipidemias were associated with the subsequent development of hypertension among healthy women. | 16287773 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1. | 16288004 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Collectively, these findings uncovered a novel function for the longevity gene sirt1 as a potential target for diagnosis and/or treatment of cancer resistance to chemotherapy. | 16288004 |
| Carcinogenesis, Colorectal Carcinoma | Deregulated Nutrient Sensing | Because both adiposity and insulin resistance have been associated with risk of colorectal cancer, we hypothesized that adiponectin is associated with colorectal carcinogenesis. | 16288122 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. | 16291982 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Selective CB1-receptor blockade with rimonabant significantly reduces body weight and waist circumference and improves the profile of several metabolic risk factors in high-risk patients who are overweight or obese and have an atherogenic dyslipidemia. | 16291982 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | Recording the presence of insulin resistance will aid the practitioner in determining if a low-risk patient is in peril for development of type 2 diabetes and/or CVD. | 16293162 |
| Increased insulin level | Deregulated Nutrient Sensing | Since hyperinsulinemia is a hallmark of T2DM, it is important to verify that increased insulin production is not due to increased insulin resistance. | 16293352 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | In these patients the most pronounced risk factors for CVD were dyslipidemia and hyperglycemia, which justify the need for the early detection of these factors as well as strict metabolic control. | 16296632 |
| Obesity | Deregulated Nutrient Sensing | In conclusion, our data indicate that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. | 16298335 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population. | 16298371 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest that higher apo C-III may contribute to the increased cardiovascular risk in subjects with insulin resistance and type 2 diabetes through its effects on triglycerides and LDL particle size. | 16298371 |
| Glucose Intolerance (disease), Periodontal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, periodontal disease has been associated with development of glucose intolerance and poor glycemic control among adults with diabetes. | 16304554 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our hypothesis is that RAGE may be involved in the evolution of insulin resistance in addition to mediating glucotoxic complications of diabetes mellitus. | 16305072 |
| Glucose Intolerance (disease), Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Risk factors for glucose intolerance in Danish women with polycystic ovary syndrome. | 16305707 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Women with polycystic ovary syndrome (PCOS) are reported to be at risk for glucose intolerance. | 16305707 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | An OGTT may be necessary to find all cases of impaired glucose intolerance. | 16305707 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The Hertfordshire Cohort Study based in the U.K. was the first to report associations between fetal or infant growth and the prevalence of adult glucose intolerance and diabetes. | 16306332 |
| Fatty Liver, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance, fatty liver, high serum leptin, hypertension, and acantosis nigricans were already evident in many slim prepubertal children. | 16306379 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was observed in 33 controls (33%) and 40 hypertensive patients (40%). | 16307156 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The present data indicate that dyslipidaemia affects a substantial proportion of healthy and hypertensive Congolese subjects. | 16307156 |
| Hypertrophy | Deregulated Nutrient Sensing | When individual variations in six month changes were examined, participants attaining the greatest increases in fitness and reductions in abdominal fatness, insulin resistance and BP showed a modest trend towards physiological hypertrophy characterised by increased cardiac size and improved LV diastolic function. | 16308413 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The dyslipidemia of type 2 diabetic patients is characterized by high VLDL, abnormal LDL composition and low HDL cholesterol concentrations. | 16308886 |
| Heat-Shock Response | Deregulated Nutrient Sensing | Induction of heat shock proteins may combat insulin resistance. | 16309849 |
| Vascular Diseases, Heat-Shock Response, Diabetes Mellitus | Deregulated Nutrient Sensing | Moreover, there is reason to believe that heat shock protein induction may have a favorable impact on the microvascular complications of diabetes, and on the increased risk for macrovascular disease associated with diabetes and insulin resistance syndrome. | 16309849 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with type 2 diabetes mellitus are at increased risk of cardiovascular disease, partly owing to dyslipidaemia, which can be amenable to fibrate therapy. | 16310551 |
| Increased insulin level, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Although the prevalence of insulin resistance (IR) and compensatory hyperinsulinemia (CH) is increased in patients with nonalcoholic fatty liver disease, the role of IR/CH in regulation of hepatic fat content in healthy volunteers with normal concentrations of alanine transaminase (ALT) has not been defined. | 16311087 |
| Atherosclerosis | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptor (PPAR)gamma is involved mainly in adipocyte differentiation and has been suggested to play an important role in the pathogenesis of insulin resistance and atherosclerosis. | 16314192 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Thirty percent had developed heart disease, hypertension, or dyslipidemia. | 16319262 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. | 16320801 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | dyslipidemia in patients with type 2 diabetes mellitus. | 16320801 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | This 12 week randomized, single-blind, placebo controlled study was conducted on Type 2 diabetic patients with newly diagnosed dyslipidemia (n=70). | 16320801 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study suggests possible small short term benefits of garlic on dyslipidemia in type 2 diabetic patients. | 16320801 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The findings show that the insulin resistance of PCOS is qualitatively different from that of type 2 diabetes. | 16322388 |
| Hypertension, CTCAE, diabetic, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among diabetic patients, the presence of severe diabetes (as defined by the coexistence of hypertension, dyslipidaemia and insulin treatment) was significantly associated with SH (adjusted odds ratio, 3.8; 95% confidence interval, 1.4-10.2; P = 0.017). | 16322389 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim of this study is to evaluate the factors contributing to increasing glucose intolerance after onset of type 2 diabetes in Japanese subjects. | 16324919 |
| Inflammation, Hyperhomocysteinemia | Deregulated Nutrient Sensing | Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children. | 16324922 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity is an independent risk factor for the development of cardiovascular disease frequently associated with hypertension, dyslipemia, diabetes, and insulin resistance. | 16324922 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The mutations of 3394 (T-->C) and 14693 (A-->G) may contribute to the genetic predisposition to type 2 diabetes; 16189 (T-->C) variant is associated with insulin resistance and risk factor of diabetes. | 16331560 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes. | 16334613 |
| Hypertension, CTCAE, Kidney Diseases, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors significantly associated with renal disease were age [P=0.018; odds ratio (OR) 2.7], hypertension (P=0.023; OR 2.13), pulse pressure (P=0.04; OR 0.10), diabetes mellitus (P=0.08; OR 4.48), obesity (P=0.000; OR 7.7), and insulin resistance index (P=0.04; OR 4.95). | 16336570 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | Potential role of interleukin-18 in liver disease associated with insulin resistance. | 16339124 |
| Hepatobiliary Disorder, Obesity | Deregulated Nutrient Sensing | Interleukin (IL)-18 has been associated with obesity and insulin resistance, both risk factors for the development of liver disease, but the role of IL-18 in liver disease associated with insulin resistance is presently unknown. | 16339124 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | IL-18 could contribute to the development of liver disease associated with insulin resistance. | 16339124 |
| Dyslipidemias | Deregulated Nutrient Sensing | LLT at discharge was positively associated with a previous medical history of dyslipidemia (P<0.001), lipid testing (P=0.004), and elevated low-density lipoprotein levels (P<0.001). | 16339479 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We also demonstrated that serum MDA levels of the patients with and those without hypertension (p = 0.846), diabetes mellitus (p = 0.891), or dyslipidemia (p = 0.38) were not significantly different. | 16340171 |
| Kidney Transplantation | Deregulated Nutrient Sensing | Because insulin resistance plays a significant role in the development of PTDM, we treated 40 consecutive patients with PTDM after liver and kidney transplantation with the insulin sensitizer rosiglitazone (ROSI). | 16340782 |
| Weight decreased | Deregulated Nutrient Sensing | Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes. | 16352858 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | The potential for early vasculopathy in individuals exposed to intermediate dose irradiation suggests a need to manage dyslipidemia and reduce vascular risk factors throughout the posttreatment period. | 16353211 |
| Klinefelter Syndrome, Hypogonadism, Primary hypogonadism, Deficiency of testosterone biosynthesis | Deregulated Nutrient Sensing | In contrast, increased insulin resistance was found in both hypergonadotropic and hypogonadotropic men with hypoandrogenism, patients with Klinefelter's syndrome and men with idiopathic gonadotropin deficiency. | 16353672 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is considered to be one of the cornerstones in the state that ultimately leads to clinically established type 2 diabetes mellitus. | 16353672 |
| Hypogonadism | Deregulated Nutrient Sensing | Therefore, supplementation with testosterone might play a role in improving both insulin resistance and hypogonadism. | 16353672 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The mechanisms by which testosterone causes insulin resistance is unknown, and larger studies on androgen treatment in type 2 diabetic patients are necessary. | 16353672 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish. | 16356084 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Increased plasma levels of thioredoxin in patients with glucose intolerance. | 16357448 |
| Glucose Intolerance (disease), Coronary Artery Disease | Deregulated Nutrient Sensing | The aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD). | 16357448 |
| Glucose Intolerance (disease), Demographics Domain | Deregulated Nutrient Sensing | In multivariate logistic regression analysis, glucose intolerance (DM or IGT) was only independently associated with the high levels of thioredoxin. | 16357448 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance was associated with the high levels of thioredoxin. | 16357448 |
| Hypertensive (finding), diabetic | Deregulated Nutrient Sensing | It has been suggested that insulin resistance is involved in the impaired vascular endothelial function not only in diabetic patients but also in hypertensive patients. | 16364837 |
| Hypertensive (finding), Endothelial dysfunction | Deregulated Nutrient Sensing | The present study assessed the hypothesis that primary treatment of insulin resistance may reverse endothelial dysfunction in hypertensive subjects. | 16364837 |
| Increased insulin level, Hypertensive (finding), Hyperglycemia | Deregulated Nutrient Sensing | The present findings demonstrate that pioglitazone improves endothelial function in nondiabetic hypertensive individuals with insulin resistance, and that the improvement is associated with the amelioration of insulin resistance itself rather than that of hyperglycemia or hyperinsulinemia. | 16364837 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Therapeutic goal attainment in patients with hypertension and dyslipidemia. | 16365611 |
| Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | We sought to ascertain treatment patterns and attainment of therapeutic goals in patients with isolated and concomitant hypertension and dyslipidemia, both with and without diabetes mellitus (DM) and symptomatic cardiovascular disease. | 16365611 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Low HDL-cholesterol and hypertriglyceridaemia are, therefore, common among European patients treated for dyslipidaemia. | 16368042 |
| Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of diabetes, hypertension, dyslipidemia, and heart failure (HF) was higher in obese patients. | 16368306 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin, an adipocyte-derived hormone is implicated in insulin resistance and atherosclerosis. | 16369465 |
| Prediabetes syndrome, Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | We conclude that decreased plasma adiponectin and insulin resistance coexist in subjects with prediabetes, diabetes and atherosclerosis. | 16369465 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin concentration is an independent correlate of insulin resistance and atherosclerosis. | 16369465 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | These interrelationships might amplify insulin resistance and endothelial dysfunction. | 16369774 |
| Ventricular Fibrillation | Deregulated Nutrient Sensing | Insulin resistance was reversed by exercise (40.1 +/- 7.7 vs. 27.6 +/- 5.6 units, P < 0.01) and correlated with changes in VF (r = 0.66, P < 0.01) and maximal oxygen consumption (r = -0.48, P < 0.05) but not adipocytokines. | 16373444 |
| Dyslipidemias, Chest Pain | Deregulated Nutrient Sensing | A moderate, but useful, increase in detection rates of dyslipidaemia is possible if lipid testing is offered to all patients presenting with chest pain, and not just to those who are admitted to wards for further investigation and management of suspected acute coronary syndromes. | 16373798 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Relationship between insulin resistance and lipid peroxidation and antioxidant vitamins in hypercholesterolemic patients. | 16373994 |
| Increased insulin level | Deregulated Nutrient Sensing | Several studies have reported that insulin resistance and compensatory hyperinsulinemia increased lipid peroxidation, suggesting the linking to each other. | 16373994 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | We investigated the relationships between insulin resistance index HOMA-IR and lipid peroxidation, plasma antioxidant status in non-diabetic, hypercholesterolemic patients. | 16373994 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Our data showed that the insulin resistance of hypercholesterolemic patients increased oxidative stress and negatively influenced plasma antioxidant system. | 16373994 |
| Glucose Intolerance (disease), Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, UAE was significantly and positively associated with cIMa in both the common carotid and the brachial arteries as well as with left ventricular septum thickness and glucose intolerance in patients with a history of previous myocardial infarction without known diabetes mellitus. | 16374441 |
| Steatohepatitis, Fibrosis Assessment, Fatty degeneration, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C. Conflicting data exist regarding the relationship between hepatitis C virus genotype 1 and hepatic steatosis as well as the latter's role in the progression of fibrosis and treatment response. | 16374856 |
| Dyslipidemias | Deregulated Nutrient Sensing | The -1131T-->C polymorphism of the apolipoprotein A-V gene (APO A-V) is tightly linked to lipid metabolism and has been associated with increased triglyceride levels and familial dyslipidemia. | 16375582 |
| Dyslipidemias, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia treatment dramatically decreases coronary heart disease risk in diabetes, yet only a minority of these patients are screened or achieve optimal low-density lipoprotein (LDL) cholesterol levels. | 16378790 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Brief educational detailing either through direct or electronic communication favorably impacts provider behavior regarding dyslipidemia care for diabetic patients. | 16378790 |
| ADIPOQ protein, human, Acromegaly | Deregulated Nutrient Sensing | The results suggest that adiponectinemia does not directly affect development of insulin resistance in acromegaly. | 16379314 |
| Glucose Intolerance (disease), Coronary Artery Disease | Deregulated Nutrient Sensing | Patients with coronary artery disease (CAD) have relatively low adiponectin levels and high prevalence of glucose intolerance. | 16381996 |
| Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | It has not been established firmly whether dyslipidemia contributes independently to the progression of kidney disease. | 16382017 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Routine laboratory data and total Hcy were recorded, as well as the history of diabetes, hypertension, dyslipidemia, and overweight. | 16382457 |
| Mitochondria, Diabetes Mellitus | Deregulated Nutrient Sensing | Recent evidence points toward mitochondrial aberrations as a major contributor to the development of insulin resistance and diabetes, and UCP3 is reduced in diabetes. | 16384852 |
| Behavior Disorders | Deregulated Nutrient Sensing | Our recent observations have indicated that insulin resistance could, at least in part, account for the pathogenesis of lifestyle-related diseases. | 16385239 |
| Behavior Disorders | Deregulated Nutrient Sensing | In addition to insulin resistance syndrome, alcohol-related diseases should be cared to address the issues of lifestyle-related diseases. | 16385239 |
| Diabetes Mellitus, Insulin-Dependent, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Clinical use of the lag plot is illustrated in seven case studies spanning the range from no diabetes, through glucose intolerance, early-onset type 2 diabetes mellitus, type 1 diabetes, intensified therapy, pump therapy, and finally islet cell transplantation. | 16386092 |
| palladium, Dyslipidemias, Mental disorders, Diabetes Mellitus | Deregulated Nutrient Sensing | Concomitant diseases and medical comorbidities such as diabetes, dyslipidemia, psychological disorders and the presence of at least one risk factor were significantly associated with PD in patients with ED. | 16386353 |
| Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Variables considered risk factors were obesity (BMI >25), dyslipidemia, hypertension, prior thoracic surgery, diabetes, and history of ischemic heart disease. | 16386612 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and weight gain secondary to lifestyle changes in living renal transplant donors. | 16387071 |
| Hyperglycemia, Prostate carcinoma | Deregulated Nutrient Sensing | Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. | 16388523 |
| Hyperglycemia, Structure of posterior cerebral artery, Cardiovascular Diseases | Deregulated Nutrient Sensing | The current data suggested that men with PCa who are receiving long-term ADT are at risk for developing insulin resistance and hyperglycemia, thus leading to their increased risk of cardiovascular disease. | 16388523 |
| Hyperparathyroidism, Primary, Hypophosphatemia | Deregulated Nutrient Sensing | Hypophosphatemia is associated with impaired glucose tolerance and insulin resistance in primary hyperparathyroidism. | 16391583 |
| Dyslipidemias | Deregulated Nutrient Sensing | Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia? | 16392769 |
| Dyslipidemias | Deregulated Nutrient Sensing | Thus, this preliminary study suggested that eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia. | 16392769 |
| Increased insulin level, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Development and progression of atherosclerotic disease in relation to insulin resistance and hyperinsulinemia. | 16392771 |
| Microunit per Milliliter | Deregulated Nutrient Sensing | The presence of insulin resistance was defined according to the guidelines reported our previous study: insulin levels of 64.0 mU/l or higher 2 h after the 75 g-OGTT. | 16392771 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | The results suggested that insulin resistance is an independent risk factor for coronary artery disease in Japanese subjects, as has also been demonstrated in the case of individuals in Europe and USA. | 16392771 |
| Ventricular Dysfunction, Left, Coronary heart disease | Deregulated Nutrient Sensing | Association between insulin resistance and impaired cardiac fatty acid metabolism may contribute to left ventricular dysfunction in patients with maintenance hemodialysis without coronary diseases. | 16395255 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance. | 16395259 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | We also investigate possible links with inflammation and the insulin resistance present in patients with chronic kidney disease (CKD). | 16395259 |
| Chronic Kidney Diseases, Dyslipidemias, Anemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | In the tertiary care of CKD, treatment of hypertension is largely inadequate, whereas therapy of anemia and dyslipidemia is frequently omitted. | 16395261 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance is an established risk factor for CHD in the general population. | 16395749 |
| Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Insulin resistance in the context of SLE was not strongly related to current or recent steroid therapy; it was, however, associated with higher levels of ox-LDL. | 16395749 |
| Choline Dehydrogenase, Mitochondrial, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Insulin resistance may therefore represent an additional CHD risk factor in patients with SLE. | 16395749 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance/compensatory hyperinsulinemia predict carotid intimal medial thickness in patients with essential hypertension. | 16399488 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To test this hypothesis, we attempted to see if there was a link between insulin resistance (IR) and carotid intimal medial thickness (IMT), an early index of CVD, in patients with essential hypertension. | 16399488 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. | 16399897 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Although statin therapy improves cardiovascular risk in diabetes, dyslipidaemia in diabetes may be more responsive to combined statin and fibrate therapy. | 16401310 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | However, in Caucasian-Brazilians, the 1888A allele was significantly associated with diabetes (12.3% in patients vs. 3.5% in control subjects; OR=3.881; 95% CI 2.106-7.164; P<0.001) and also with higher levels of insulin resistance. | 16401312 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The present study indicates the association of the mitochondrial G1888A variant with Type 2 diabetes and insulin resistance in Caucasian-Brazilian patients from southern Brazil. | 16401312 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance. | 16402923 |
| diabetic | Deregulated Nutrient Sensing | Twenty-one patients undergoing diabetic treatments (two mild, nine moderate and 10 severe) were excluded from the assessment of insulin resistance and plasma adiponectin measurements. | 16402923 |
| Obesity | Deregulated Nutrient Sensing | Sleep-disordered breathing was associated with insulin resistance independent of obesity. | 16402923 |
| Sleep-Disordered Breathing, Sleep Apnea, Obstructive, Obesity | Deregulated Nutrient Sensing | Although treatment of sleep-disordered breathing with nasal continuous positive airway pressure reportedly improves insulin sensitivity, our findings suggest that treatment of obesity is also essential in ameliorating insulin resistance at least through increased plasma adiponectin levels in OSAS. | 16402923 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia is an important, modifiable CHD risk factor. | 16404837 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia increased with advancing age and increasing BMI; notwithstanding, a high prevalence of dyslipidemia was observed in the youngest tertile as well. | 16404837 |
| Inflammation, Demographics Domain, Dyslipidemias, Kidney Diseases, Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia and inflammation may promote renal disease via mechanisms of vascular endothelial cell dysfunction in type II diabetes mellitus (DM). | 16408124 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Both conditions (NAFL and NASH) occur in the setting of peripheral insulin resistance. | 16416185 |
| Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | Recently, obstructive sleep apnea (OSA) has been proposed as an independent risk factor for insulin resistance. | 16416185 |
| Steatohepatitis | Deregulated Nutrient Sensing | Greater insulin resistance can result in more severe hepatic steatosis among group B patients, leading to an overproduction of reactive oxygen species, which may accelerate telomere erosion. | 16420506 |
| Cardiovascular morbidity, Dyslipidemias | Deregulated Nutrient Sensing | However, increased cardiovascular morbidity and dyslipidaemia have also been recognized in mild pHPT, which also seem to be normalized after parathyroidectomy. | 16420548 |
| Hypercholesterolemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | 11.2 dollars for high blood pressure, 3.8 dollars for diabetes, and 30.6 dollars for dyslipidemia (using generic drugs except for hypercholesterolemia). | 16423280 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, serum adiponectin was lowered in women with type 2 diabetes mellitus, and this difference could only be partly explained by insulin resistance, insulin secretion, family history of diabetes, and inflammation. | 16423625 |
| Diabetes Mellitus, Non-Insulin-Dependent, MS gene | Deregulated Nutrient Sensing | This study demonstrates that increased levels of sP-selectin and sCD40L are seen in Asian Indian subjects with IGT, type 2 diabetes mellitus, MS, and insulin resistance. | 16423632 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. | 16423904 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Evaluation of insulin resistance was made through the HOMA, QUICKI and McAuley indices and the triglycerides/high density lipoprotein (HDL) cholesterol ratio. | 16428124 |
| Hepatitis, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | As would be expected, hypertension, dyslipidaemia, diabetes and heart disease were the most common comorbidities; renal failure and hepatitis were least likely. | 16428152 |
| Obesity | Deregulated Nutrient Sensing | Other features of FCH are obesity and insulin resistance. | 16432543 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Serum leptin levels have also been associated with obesity, insulin resistance and atherosclerosis. | 16432543 |
| Obesity | Deregulated Nutrient Sensing | A difference in high-density lipoprotein cholesterol (HDL-c) levels was present between carriers and non-carriers of an Arg allele, 1.21 vs 1.28 mmol/l, respectively (P=0.04), but no differences in obesity, insulin resistance and other lipid parameters were found. | 16432543 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Obesity | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is associated with menstrual and reproductive abnormalities, insulin resistance, and obesity. | 16434451 |
| Prostate Cancer Outcomes Study, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of PCOS and targeted cardiovascular risk factors [hypertension, dyslipidemia, diabetes mellitus, and body mass index (BMI)] were measured. | 16434451 |
| Cholelithiasis, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Serum insulin, insulin resistance, beta-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: a community-based study in Kinmen, Taiwan. | 16437664 |
| Cholelithiasis, Beta-cell dysfunction | Deregulated Nutrient Sensing | To explore the association of serum insulin, insulin resistance, and beta-cell dysfunction with gallstone disease (GSD) in type 2 diabetics. | 16437664 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Serum insulin, insulin resistance, and beta-cell dysfunction are risk factors for GSD in females, but not males with type 2 diabetes. | 16437664 |
| Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, TYMS wt Allele, Turner Syndrome | Deregulated Nutrient Sensing | Mild insulin resistance appears to be an early metabolic defect in girls with Turner syndrome (TS). | 16439845 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Tachycardia, Ventricular | Deregulated Nutrient Sensing | Dyslipidemia is associated with ventricular tachyarrhythmia in patients with acute ST-segment elevation myocardial infarction. | 16440066 |
| Tachyarrhythmia, Dyslipidemias | Deregulated Nutrient Sensing | This study suggests that dyslipidemia imposes a higher risk of developing tachyarrhythmia in the acute phase of STEMI. | 16440066 |
| Dyslipidemias | Deregulated Nutrient Sensing | Recent guidelines have targeted low-density lipoprotein (LDL) cholesterol for treatment of dyslipidemia. | 16442398 |
| Mucoepidermoid Carcinoma | Deregulated Nutrient Sensing | Mucoepidermoid carcinomas (MECs) of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) translocation resulting in a MECT1-MAML2 fusion in which the CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2. | 16444749 |
| Scoliosis, unspecified, Dyslipidemias, CLEFT LIP/PALATE WITH ABNORMAL THUMBS AND MICROCEPHALY | Deregulated Nutrient Sensing | Dysautonomia, dyslipidemia, and scoliosis were more frequent in VEDS patients than in JHS patients. | 16447226 |
| Somatotropin deficiency, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | An atherogenic lipid profile, insulin resistance, obesity, and increased body and trunk fat in GHD adults may cause the higher risk of cardiovascular disease in these patients. | 16449951 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Obesity | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is associated with insulin resistance and a high incidence of obesity. | 16452543 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, hypertension, and dyslipidemia in Mexican Americans and non-Hispanic whites. | 16459207 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Awareness of hypertension and dyslipidemia are significantly lower in Mexican Americans (57% vs 71% for hypertension, and 33% vs 56% for dyslipidemia). | 16459207 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Treatment rates for hypertension and dyslipidemia are also significantly lower in Mexican Americans (42% vs 61% for hypertension; 14% vs 30% for dyslipidemia). | 16459207 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The significantly higher prevalence of diabetes in Mexican Americans, in contrast to hypertension and dyslipidemia, may sensitize healthcare providers to its detection and treatment. | 16459207 |
| Gestational Diabetes, Diabetes Mellitus | Deregulated Nutrient Sensing | GDM mothers in urban India are more obese and more adipose than non-diabetic mothers, frequently have a family history of diabetes and show metabolic features of insulin resistance syndrome, suggesting high cardiovascular risk. | 16459528 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. | 16461837 |
| Dyslipidemias | Deregulated Nutrient Sensing | Black and Hispanic Americans had prevalence of dyslipidemia that was comparable to that of non-Hispanic whites but were less likely to be treated and controlled. | 16461837 |
| Dyslipidemias | Deregulated Nutrient Sensing | Control of dyslipidemia was achieved less commonly in the CVD high- and intermediate-risk groups than in the low-risk group. | 16461837 |
| Glucose Intolerance (disease), Thalassemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Evolution of glucose intolerance and diabetes in transfused patients with thalassemia. | 16462709 |
| Depressed mood | Deregulated Nutrient Sensing | We propose that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver. | 16463046 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Elevated plasma glucose can further increase hepatic fat content through multiple pathways, resulting in overproduction of VLDL(1) particles and leading to the characteristic dyslipidaemia associated with type 2 diabetes. | 16463046 |
| Dyslipidemias | Deregulated Nutrient Sensing | The effect of simvastatin on triglyceride-rich lipoproteins in patients with type 2 diabetic dyslipidemia: a SILHOUETTE trial sub-study. | 16466606 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | To determine if simvastatin effectively decreases the elevated levels of triglyceride (TG), TG-rich lipoproteins, and small, dense LDL particles, which are characteristic of diabetic dyslipidemia. | 16466606 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The incidence of dyslipidaemias was of 61% with hypercholesterolaemia and hypertriglyceridaemia rates of 41% and 21%, respectively. | 16468265 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The role of dyslipidemia is essential in the development of atherosclerosis, therefore continuing care of dyslipidemic patients is an extremely important task in cardiovascular prevention. | 16468604 |
| Atherosclerosis | Deregulated Nutrient Sensing | Towards understanding of glycaemic index and glycaemic load in habitual diet: associations with measures of glycaemia in the Insulin Resistance Atherosclerosis Study. | 16469159 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Potatoes, a high glycemic form of carbohydrate, are hypothesized to increase insulin resistance and risk of type 2 diabetes. | 16469985 |
| Hyperlipidemia, Fatty Liver Disease | Deregulated Nutrient Sensing | Fifty-four children diagnosed as NASH showed significantly higher incidence of hyperlipidemia, insulin resistance and higher body mass index as compared with 24 subjects without fatty liver changes. | 16470923 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Severe disturbance of lipid metabolism and insulin resistance may be involved in the mechanism of NASH. | 16470923 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The patients had no history of myocardial infarction, coronary revascularisation, familial dyslipidaemia, diabetes or renal disease. | 16473514 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Numerous studies have shown that psychosocial stresses lead to the disturbance of the metabolism of lipids, insulin resistance and eventually to cardiovascular diseases. | 16480250 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of 'at least one risk factor' from the three major cardiovascular risk factors (hypertension, dyslipidaemia and diabetes) was also evaluated. | 16480535 |
| Cardiac Hypertrophy | Deregulated Nutrient Sensing | Mutations in the gene encoding the gamma2 subunit of AMP-activated protein kinase (PRKAG2) cause familial cardiac hypertrophy and electrophysiological abnormalities, with glycogen accumulation in the heart of affected patients. | 16487706 |
| Dyslipidemias, Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is one of the main risk factors for atherosclerosis, usually the underlying cause of cardiovascular diseases which are the major cause of morbidity and mortality in developed countries. | 16487912 |
| Obesity | Deregulated Nutrient Sensing | Influence of obesity and insulin resistance on left atrial size in children. | 16489973 |
| Hypertrophy, Obesity | Deregulated Nutrient Sensing | Left atrial (LA) enlargement has been linked to obesity and insulin resistance in adults. | 16489973 |
| Hypertrophy, Cardiovascular Diseases | Deregulated Nutrient Sensing | LA enlargement is present in childhood and is related to abdominal OB and insulin resistance, suggesting that children with central OB are at increased risk for cardiovascular disease. | 16489973 |
| Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus and insulin resistance are associated with an increased risk of myocardial infarction (MI). | 16490431 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Smoking should be stopped and hypertension, diabetes mellitus, dyslipidaemia and hypothyroidism treated. | 16492065 |
| Endothelial dysfunction, diabetic | Deregulated Nutrient Sensing | Adipocytokines are involved in the development of insulin resistance and endothelial dysfunction in diabetic patients. | 16492207 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alcohol use may confer increased risks not only of type 2 diabetes mellitus but also of preceding glucose intolerance status. | 16494963 |
| TG gene, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | It has been well established that dyslipidemia is a significant risk factor for coronary artery disease (CAD), however, the association between fasting triglyceride (TG) and the occurrence of CAD is controversial. | 16501284 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Kidney transplant recipients are prone to hypertension, dyslipidemia, and cardiovascular death. | 16504676 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The associated SNPs and haplotype are the same as those observed to be associated with type 2 diabetes, insulin resistance, and fasting glucose in previous studies. | 16505227 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. | 16505254 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Thus, the genes that encode the various AMPK subunits are intriguing candidates for the inherited basis of type 2 diabetes. | 16505254 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We therefore set out to test for the association of common variants in the genes that encode three selected AMPK subunits with type 2 diabetes and related phenotypes. | 16505254 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Of the seven genes that encode AMPK isoforms, we initially chose PRKAA2, PRKAB1, and PRKAB2 because of their higher prior probability of association with type 2 diabetes, based on previous reports of genetic linkage, functional molecular studies, expression patterns, and pharmacological evidence. | 16505254 |
| Obesity | Deregulated Nutrient Sensing | Plasminogen activator inhibitor 1 is thought to play a role in the pathogenesis of obesity and insulin resistance. | 16507937 |
| Edema, diabetic | Deregulated Nutrient Sensing | Pioglitazone improved glycaemic control and inflammatory markers over 9 weeks but had no effect on microcirculatory variables associated with oedema or insulin resistance in type 2 diabetic patients treated with insulin. | 16508777 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | A recent study indicated that having deep pockets is significantly associated with past development of glucose intolerance in non-diabetic individuals using an oral glucose tolerance test (OGTT). | 16512753 |
| Gout | Deregulated Nutrient Sensing | [Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)]. | 16514819 |
| Gout | Deregulated Nutrient Sensing | To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR). | 16514819 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia associated with insulin resistance is an independent risk factor in the development of BPH. | 16516184 |
| Increased insulin level, Dyslipidemias, Benign prostatic hypertrophy | Deregulated Nutrient Sensing | Hyperinsulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia. | 16516184 |
| Increased insulin level, Metabolic Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Previous studies have reported the association between hyperinsulinemia, dyslipidemia and BPH in patients with metabolic disorders like diabetes. | 16516184 |
| Gall Bladder Diseases | Deregulated Nutrient Sensing | Gallbladder disease is associated with insulin resistance in a high risk Hispanic population. | 16516330 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | GS is associated to insulin resistance, fatty liver and to metabolic syndrome, but not to serum CRP in a high risk Hispanic population. | 16516330 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | High levels of IL-6 are associated with hyperglycaemia, dyslipidemia and provoke insulin resistance. | 16518702 |
| Ischemic cardiomyopathy | Deregulated Nutrient Sensing | In conclusion, high levels of IL-6 unmask the phenotypes (higher insulin resistance and zinc deficiency) in relation to the genotypes with subsequent risk of developing ischaemic cardiomyopathy in NIDDM-atherosclerotic patients carrying AA genotype. | 16518702 |
| Dyslipidemias | Deregulated Nutrient Sensing | The study revealed that dyslipidemia is very common in type 2 diabetics and the most common abnormality seen was increased serum triglyceride levels (73.3%). | 16519073 |
| Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The associated cardiovascular risk factors such as diabetes, hypertension, dyslipidemia, previous myocardial infarction and previous coronary artery bypass grafting/percutaneous transluminal coronary angioplasty were similar in both the groups. | 16521631 |
| Hyperplastic Polyp | Deregulated Nutrient Sensing | Relationships between MP concentrations and parameters reflecting insulin resistance in patients were also studied. | 16523191 |
| Apolipoproteins B, Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Since adiponectin and chronic subclinical inflammation have been reported to predict the development of type 2 diabetes and since abnormalities in apolipoprotein B metabolism occur in the early course of insulin resistance, these findings may be compatible with the association between liver markers and risk of diabetes. | 16523413 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | There is no certain evidence about the incidence of diabetes mellitus under the influence of corticosteroids, due to increase of hepatic glucose production, insulin resistance and exhaustion of pancreatic beta-cells because of stimulated endogenous secretion. | 16526267 |
| Hyperglycemia, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | The present findings suggest that compliance with clinical recommendations in primary care as a measure to retard complications in patients with type 2 diabetes should be improved, especially with regard to control of hyperglycaemia, hypertension and dyslipidemia. | 16529163 |
| Nonalcoholic Steatohepatitis, Chronic liver disease, Fibrosis Assessment, Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic steatohepatitis (NASH) is common cause of chronic liver disease strongly associated with insulin resistance leading to fibrosis. | 16531962 |
| Hypertensive (finding), Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is associated with high risk for cardiovascular disease and lipid management is arguably necessary, especially in hypertensive subjects. | 16532712 |
| Dyslipidemias | Deregulated Nutrient Sensing | Urgent strategies are required to prevent increasing levels of dyslipidaemia in Thailand, as well as to develop and promulgate treatment guidelines that incorporate locally-relevant risk prediction functions. | 16536111 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Carotenoids may reduce the risk for diabetes mellitus, but little is known about the association of insulin resistance with serum carotenoids in non-diabetic subjects. | 16537987 |
| Atherosclerosis | Deregulated Nutrient Sensing | Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis. | 16538000 |
| atherosclerotic | Deregulated Nutrient Sensing | Glimepiride appears to improve insulin resistance and atherosclerotic disorders. | 16538000 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Haemochromatosis subjects with diabetes exhibited further declines in acute insulin response to glucose, insulin resistance, or both. | 16538487 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes is usually associated with obesity and concomitant insulin resistance. | 16538487 |
| Diabetes Mellitus, Non-Insulin-Dependent, Increased insulin level, Breast Carcinoma | Deregulated Nutrient Sensing | There is growing evidence of a link between type 2 diabetes and breast cancer, possibly through insulin resistance and/or hyperinsulinemia. | 16538527 |
| Breast Carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Further studies are required to better characterize the processes that link insulin resistance, diabetes and breast cancer. | 16538527 |
| Rheumatoid Arthritis, Necrosis | Deregulated Nutrient Sensing | Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis. | 16539824 |
| Inflammation, Cardiovascular Diseases, Refractory anemias, Rheumatoid Arthritis, Endothelial dysfunction | Deregulated Nutrient Sensing | Systemic inflammation, insulin resistance, and endothelial dysfunction have been implicated in the development of cardiovascular disease in rheumatoid arthritis (RA). | 16539824 |
| Refractory anemias, Endothelial dysfunction | Deregulated Nutrient Sensing | Since insulin resistance can promote endothelial dysfunction and anti-TNF-alpha blockade yield a rapid improvement of endothelial function, we have sought to assess whether TNF-alpha blockade may also result in a reduction of insulin serum levels and improvement of insulin resistance in RA patients who require this therapy because of severe and refractory disease. | 16539824 |
| Refractory anemias | Deregulated Nutrient Sensing | Our study confirms a rapid beneficial effect of infliximab on insulin resistance and insulin sensitivity in RA patients treated periodically with this drug. | 16539824 |
| Obesity | Deregulated Nutrient Sensing | Although data suggest that physical activity is associated with decreased insulin resistance, recommendations for exercise training are not specific for age or level of obesity. | 16540829 |
| Diabetes Mellitus, Non-Insulin-Dependent, Increased insulin level, Breast Carcinoma | Deregulated Nutrient Sensing | Evidence suggests that women with type 2 diabetes may be at increased risk of breast cancer, possibly due to chronic exposure to insulin resistance and/or hyperinsulinemia. | 16541321 |
| Diabetes Mellitus, Non-Insulin-Dependent, Breast Carcinoma | Deregulated Nutrient Sensing | These results support the possibility that insulin resistance or some other aspect of type 2 diabetes may promote breast cancer, and may further direct treatment and prevention strategies. | 16541321 |
| Neoplasms | Deregulated Nutrient Sensing | Based on the observations that SIRT1 is upregulated in tumor cells, the hypothesis is that deregulation of SIRT1 expression may promote tumorigenesis by altering cellular signaling or by inducing modulation of chromatin remodeling leading to promotion of tumorigenesis. | 16546327 |
| Hypertensive (finding), Damage, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidaemia, high plasma glucose levels, the duration of hypertension and being on antihypertensive therapy appear to be the main predictors of hypertensive cardiac damage. | 16547554 |
| Inflammation, Hypertension, CTCAE, Diabetes Mellitus, Congestive heart failure | Deregulated Nutrient Sensing | Stepwise adjustment for inflammation, hypertension, insulin resistance, and diabetes mellitus did not decrease the relative risk of a greater waist circumference for the development of CHF (all HR=1.27-1.32, 95% CI=1.02-1.61 per SD increase). | 16551307 |
| Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity, inflammation, insulin resistance and cardiovascular disease (CVD) risk are inter-related. | 16552404 |
| Hypertension, CTCAE, Atherosclerosis | Deregulated Nutrient Sensing | Physical activity, insulin sensitivity, and hypertension among US adults: findings from the Insulin Resistance Atherosclerosis Study. | 16554349 |
| Inflammation, Dyslipidemias, Heart failure, Coronary heart disease | Deregulated Nutrient Sensing | Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease. | 16556684 |
| Inflammation, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Serum adiponectin is associated with the presence of atherogenic dyslipidemia and with NT-proBNP concentration but not with markers of systemic inflammation in patients with manifest CHD. | 16556684 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Thus, atherogenic dyslipidemia may link adiponectin with the progression of atherosclerosis. | 16556684 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease | Deregulated Nutrient Sensing | Although small dense low-density lipoprotein (sd-LDL) has an established association with diabetic dyslipidemia, previous studies have failed to show an association between sd-LDL and diabetes among coronary heart disease patients. | 16565554 |
| diabetic, Atherosclerosis | Deregulated Nutrient Sensing | The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. | 16567536 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance is promoted already in childhood by obesity and possibly by high-saturated fat intake. | 16567815 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Sex- and season-dependent differences in residual functional beta cell mass and/or insulin resistance have been identified at diagnosis of type 1 diabetes. | 16570164 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Visceral adipose tissue as an indicator of insulin resistance in nonobese patients with new onset type 2 diabetes mellitus. | 16570234 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and type 2 diabetes mellitus are characterized by insulin resistance. | 16570234 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We determined the relationship between insulin resistance and visceral adipose tissue (VAT) and their correlation with bioimpedance analysis in nonobese new onset type 2 diabetes patients. | 16570234 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was also found in a significant number of cases, mostly elevated LDL, low HDL and elevated Lp(a). | 16570759 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia correlating to insulin resistance is one of the key features in type 2 diabetes (T2D). | 16572495 |
| Obesity | Deregulated Nutrient Sensing | This association is independent of obesity, insulin resistance, and the content of triglycerides within HDL particles. | 16574896 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Increased serum uric acid (SUA) levels are linked to obesity, dyslipidemia, diabetes and hypertension. | 16575272 |
| Obesity | Deregulated Nutrient Sensing | We speculate that the escalating prevalence of obesity and insulin resistance among adolescents might negatively influence male reproductive function for the next generation. | 16582411 |
| Glucose Intolerance (disease), Fibrosis Assessment | Deregulated Nutrient Sensing | C282Y/H63D compound heterozygous individuals who had glucose intolerance had more severe fibrosis compared with those without glucose intolerance (1.0+/-1.0 vs. 0.1+/-0.3, P=0.01). | 16584391 |
| Glucose Intolerance (disease), Fibrosis Assessment | Deregulated Nutrient Sensing | However, glucose intolerance may be important risk factor for the development of hepatic fibrosis in subjects with the C282Y/H63D HFE genotype. | 16584391 |
| Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | We studied in the Insulin Resistance Atherosclerosis Study the relation of incident diabetes to dynamic changes of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen. | 16585388 |
| Obesity | Deregulated Nutrient Sensing | However, its role in the treatment of insulin resistance and obesity in children and adolescents is less clearly defined. | 16595599 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. | 16596166 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb gene silencing in Drosophila. | 16596166 |
| Breast Carcinoma | Deregulated Nutrient Sensing | In contrast, inhibition of SIRT1 by pharmacologic, dominant negative, and siRNA (small interfering RNA)-mediated inhibition in breast and colon cancer cells causes increased H4-K16 and H3-K9 acetylation at endogenous promoters and gene re-expression despite full retention of promoter DNA hypermethylation. | 16596166 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Furthermore, SIRT1 inhibition affects key phenotypic aspects of cancer cells. | 16596166 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In CARDIA, higher serum carotenoid concentrations are associated with lower risk of diabetes and insulin resistance in nonsmokers but not in smokers. | 16597706 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | After myocardial infarction carvedilol improves insulin resistance compared to metoprolol. | 16598518 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | We compared effects of carvedilol and metoprolol on insulin resistance and serum lipid levels after myocardial infarction. | 16598518 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | In patients after myocardial infarction, carvedilol added to background therapy improved insulin resistance and lipid profile. | 16598518 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Data on dyslipidemia in type 1 diabetes is scarce. | 16603826 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Good management of diabetes seems to be of paramount importance in controlling dyslipidemia. | 16603826 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate. | 16606809 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Development of insulin resistance (IR) may be important in the pathogenesis of both metabolic syndrome and type 2 diabetes mellitus. | 16606809 |
| Cessation of life, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | To study the benefit of the therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (simvastatin) associated with diet in treating dyslipidemia in elderly patients, considering that they are more exposed to sudden death, myocardial infarction and stroke. | 16610166 |
| Cessation of life, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Based on the fact that dyslipidemia is a major, independent cardiovascular risk factor, we consider that therapy with hydroxymethylglutaryl coenzyme-A-reductase inhibitors is beneficial in elderly patients because of their efficacity, minimal side effects and protection against sudden death, myocardial infarction and stroke. | 16610166 |
| Hyperthyroidism | Deregulated Nutrient Sensing | Serum levels of ghrelin and its relationship with insulin resistance were evaluated in 48 patients with hyperthyroidism and 43 euthyroid healthy controls. | 16612106 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance. | 16612564 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | YKL-40 participates in inflammatory states and vascular processes, which implies that comparison can be made with other inflammatory markers associated with insulin resistance and type 2 diabetes (T2D). | 16612564 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | YKL-40 and hsCRP are elevated in patients with T2D and are related to insulin resistance. | 16612564 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance is an important risk factor for coronary artery disease. | 16614503 |
| Increased insulin level, No metabolic abnormalities | Deregulated Nutrient Sensing | Although several observations suggest that insulin resistance/compensatory hyperinsulinemia (IR/CH) has a direct effect on endothelial function, independently of the metabolic abnormalities associated with the defect in insulin action, this relation has not been evaluated in apparently healthy individuals. | 16616036 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | None of the men had known history of diabetes or dyslipidemia. | 16617314 |
| Increased insulin level, Glucose Intolerance (disease), Dyslipidemias | Deregulated Nutrient Sensing | Development of cookie test for the simultaneous determination of glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia. | 16618974 |
| Increased insulin level, Glucose Intolerance (disease), Dyslipidemias | Deregulated Nutrient Sensing | A new cookie test was developed for the simultaneous evaluation of multiple risk factors such as glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia. | 16618974 |
| Increased insulin level, Postprandial hyperlactemia | Deregulated Nutrient Sensing | In addition, hyperinsulinemia, insulin resistance (AUC insulin, and/or AUC insulin X AUC glucose), and postprandial hyperlipidemia (DeltaTG, Triglyceride; DeltaRLP, remnant like particles) have been simultaneously uncovered. | 16618974 |
| Increased insulin level, Behavior Disorders, Diabetes Mellitus, Postprandial hyperlactemia | Deregulated Nutrient Sensing | In 64 subjects with lifestyle-related diseases, cookie test revealed hyperinsulinemia and insulin resistance in 56% respectively, postprandial hyperlipidemia in 39%, diabetes and IGT in 22-23% of each of the subjects and all showed at least one abnormal value. | 16618974 |
| Increased insulin level, Glucose Intolerance (disease), Postprandial hyperlactemia | Deregulated Nutrient Sensing | Simultaneous evaluation of glucose intolerance, hyperinsulinemia, insulin resistance, and postprandial hyperlipidemia was also possible. | 16618974 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The risk factors of hypertension, poor glycaemic control, dyslipidaemia and cigarette smoking were present in a fair proportion of the study patients. | 16619728 |
| Metabolic Diseases, Overweight | Deregulated Nutrient Sensing | Insulin resistance in Brazilian adolescent girls: association with overweight and metabolic disorders. | 16621110 |
| Overweight | Deregulated Nutrient Sensing | Brazilian overweight girls with higher insulin resistance had high risk of developing MS. | 16621110 |
| TG gene, diabetic | Deregulated Nutrient Sensing | Our study results suggest that PG suppresses increases in postprandial glucose and TG levels, and improves insulin resistance; and, in addition, that PG may have a favorable impact on oxidative stress in type 2 diabetic patients. | 16622303 |
| Immunoglobulin M, Dyslipidemias, Blood Glucose | Deregulated Nutrient Sensing | Patients with IGM had more dyslipidemia, higher levels of fasting glycemia, triglycerides and urea and lower HDL cholesterol. | 16623355 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular risk factors were found in a significant proportion of our sample (hypertension in 56.3%, diabetes mellitus in 38.0%, current or previous smoking in 51.4%, dyslipidemia in 67.6%). | 16623357 |
| Inflammation | Deregulated Nutrient Sensing | It has already been demonstrated that insulin resistance (IR) is associated with the stimulation of erythroid progenitors and with increased levels of inflammation markers. | 16628283 |
| Microalbuminuria | Deregulated Nutrient Sensing | The systolic blood pressure, high sensitive C-reactive protein (hsCRP) and insulin resistance were independently related with microalbuminuria on the logistic regression analysis. | 16629224 |
| Microalbuminuria | Deregulated Nutrient Sensing | These finding suggest that the systolic blood pressure, hsCRP and insulin resistance are the independent risk factors for microalbuminuria in normoglycemic, normotensive adults. | 16629224 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Waist and hip circumferences were both positively associated with the presence of hypertension, dyslipidemia, and diabetes. | 16631430 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | However, after adjustment for BMI and age, hip circumference exhibited a significant dose-dependent inverse relationship with dyslipidemia and diabetes in women, but not men. | 16631430 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Increasing adjusted waist circumference was associated with increased risk of hypertension and diabetes in Chinese and dyslipidemia in women only. | 16631430 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The value of u-ACR was significantly higher in patients with dyslipidemia (P<.001) but not in those with CA stenosis or hypertension. | 16632783 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | A drop of less than 10% from mean daytime values (nondipping) is associated with chronic kidney disease, insulin resistance, and cardiovascular events. | 16636209 |
| Dyslipidemias, Hyperlipoproteinemias | Deregulated Nutrient Sensing | As such, in patients with type III hyperlipoproteinemia, it is essential to search for exacerbating factors, particularly because the amelioration of such factors may rectify the effects of the underlying dyslipidemia. | 16638727 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Association between adiponectin, insulin resistance, and endometrial cancer. | 16639730 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | The authors hypothesized that insulin resistance also contributes to an increased risk for endometrial cancer. | 16639730 |
| Increased insulin level | Deregulated Nutrient Sensing | Adiponectin is a protein secreted by adipose cells and has been shown to be a surrogate marker for insulin resistance, with low levels of adiponectin correlated with hyperinsulinemia and degree of insulin resistance. | 16639730 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | This suggested that insulin resistance is independently associated with endometrial cancer. | 16639730 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Association between insulin resistance and endothelial dysfunction in renal transplant recipients. | 16640526 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Endothelial dysfunction is significantly associated with insulin resistance in normoglycemic RTR but explains a rather small part of the variation. | 16640526 |
| Communicable Diseases | Deregulated Nutrient Sensing | Burden of infection and insulin resistance in healthy middle-aged men. | 16644637 |
| Communicable Diseases, Inflammation | Deregulated Nutrient Sensing | We hypothesized that burden of infection could be associated with chronic low-grade inflammation, resulting in insulin resistance. | 16644637 |
| Enterovirus | Deregulated Nutrient Sensing | Pathogen burden showed the strongest association with insulin resistance, especially with enteroviruses and C. pneumoniae seropositivity. | 16644637 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and microalbuminuria: a cross-sectional, case-control study of 158 patients with type 2 diabetes and different degrees of urinary albumin excretion. | 16644705 |
| Microalbuminuria | Deregulated Nutrient Sensing | A role for insulin resistance in the pathogenesis of microalbuminuria has been suggested but is still unproven. | 16644705 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In type 2 diabetes, more severe insulin resistance is independently associated with microalbuminuria. | 16644705 |
| Microalbuminuria | Deregulated Nutrient Sensing | Longitudinal studies are needed to clarify the role of insulin resistance in the pathogenesis of microalbuminuria and related complications. | 16644705 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. | 16644716 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although the -592C/A polymorphism was not associated with type 2 diabetes, nondiabetic homozygous carriers of the A allele showed increased BMI and insulin resistance and lower plasma IL-10 levels compared with the other genotypes. | 16644716 |
| Obesity | Deregulated Nutrient Sensing | The ATA/ATA composite genotype was associated with an increased risk for obesity (1.96 [1.16-3.31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01). | 16644716 |
| Obesity | Deregulated Nutrient Sensing | This study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians. | 16644716 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | High circulating IL-6 levels have been associated with insulin resistance and greater risk of type 2 diabetes. | 16644865 |
| Cholestatic liver disease, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The recognition of dyslipidemia and atherosclerosis in those with cholestatic liver disease and the normalization of lipid profile after liver transplantation warrant further study. | 16645435 |
| Hypertensive (finding), Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular risk factors as Body Mass Index (BMI), diabetes, a family history of dyslipidemia and diabetes were more frequent among prehypertensive and hypertensive individuals, than in normotensive ones. | 16649511 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Patients had an overall prevalence of smoking, obesity, hypertension, dyslipidemia, and diabetes mellitus about twice that of the reference group. | 16649830 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Although previous studies have shown that African subjects have a lower visceral adipose depot size than European subjects, abdominal obesity is still associated with insulin resistance and dyslipidaemia. | 16649973 |
| Primary malignant neoplasm, Neoplasms, Eccrine acrospiroma | Deregulated Nutrient Sensing | Clear cell hidradenoma of the skin--a third tumor type with a t(11;19)-associated TORC1-MAML2 gene fusion: Genes Chromosomes Cancer. | 16670462 |
| Arterial Stiffness, Antihypertensive Agents | Deregulated Nutrient Sensing | Insulin resistance is associated with arterial stiffness in nondiabetic hypertensives independent of metabolic status. | 16671332 |
| Arterial Stiffness, Hypertensive (finding) | Deregulated Nutrient Sensing | We sought to determine whether insulin resistance (IR) is related to arterial stiffness in nondiabetic hypertensive patients, independent of metabolic status and gender. | 16671332 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Beta cell function, insulin resistance and plasma adiponectin concentrations are predictors for the change of postprandial glucose in non-diabetic subjects at risk for type 2 diabetes. | 16673209 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, impaired insulin secretion, and low adiponectin levels have been shown to be predictors for type 2 diabetes. | 16673209 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Approximately 15-40% of the patients had obtained the treatment goals for hypertension, dyslipidemia and type 2 diabetes. | 16674875 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Effect of postprandial insulinemia and insulin resistance on measurement of arterial stiffness (augmentation index). | 16675046 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia and elevated blood pressure are associated significantly already with modest rises in waist girth adjusted for age and smoking. | 16678831 |
| Overweight, Obesity | Deregulated Nutrient Sensing | As the prevalence of overweight and obesity increases, the risk of insulin resistance rises. | 16679218 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus. | 16681424 |
| Proteinuria, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In the New-DM patients, 41.8% were accompanied with hypertension, 43.2% with proteinuria, and 67.6% with dyslipidemia. | 16681969 |
| Proteinuria, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Proteinuria, dyslipidemia, and hypertension were the concomitant disorders frequently found in New-DM. | 16681969 |
| Beta-cell dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Both insulin resistance and beta-cell dysfunction are implicated in this patients' diabetes pathophysiology. | 16684489 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Overweight or obesity, dyslipidemia and insulin resistance were risk factors of hypertension in Mongolian people. | 16685579 |
| Dyslipidemias | Deregulated Nutrient Sensing | Among 4,885 patients receiving treatment for dyslipidemia, 79.7% were non-Hispanic white (NHW) and 8.4% were AA. | 16686806 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance. | 16691186 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type II diabetes is caused by a failure of the pancreatic beta-cells to compensate for insulin resistance leading to hyperglycaemia. | 16691186 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | FASL and FAS map to loci linked to type II diabetes and estimates of insulin resistance, respectively. | 16691186 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We conclude that polymorphisms of FASL and FAS associate with type II diabetes and estimates of insulin resistance in Danish white subjects. | 16691186 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This drug, because of its decreasing effect on insulin resistance, is used alone or combined with type 2 diabetic drugs. | 16698744 |
| Dyslipidemias | Deregulated Nutrient Sensing | Statins, drugs used to treat dyslipidemia, may have anticancer properties. | 16702371 |
| Glucose Intolerance (disease), Hyperparathyroidism, Primary | Deregulated Nutrient Sensing | Prevalence of glucose intolerance in primary hyperparathyroidism and the benefit of parathyroidectomy. | 16703622 |
| Demographics Domain, Glucose Intolerance (disease), Hyperparathyroidism, Primary, Diabetes Mellitus | Deregulated Nutrient Sensing | Increased prevalence of diabetes mellitus (DM) in primary hyperparathyroidism (PHPT) is established, but not glucose intolerance (GI), nor benefit from parathyroidectomy on GI. | 16703622 |
| Coronary Artery Disease, Dyslipidemias, Heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients who died were older, more frequently had a history of diabetes or coronary artery disease, were more likely to have heart failure at admission, had higher troponin-I, myoglobin and creatinine levels, and were less likely to have dyslipidemia or to be a smoker. | 16712744 |
| Inflammation, Cardiovascular Diseases | Deregulated Nutrient Sensing | Plasma leptin is associated with insulin resistance, inflammation and disturbances in haemostasis independent of waist circumference, suggesting possible pathways by which leptin may influence risk of cardiovascular disease. | 16712853 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | The prevalence of insulin resistance, general and abdominal obesity, low HDL-C and physical inactivity was higher in women than men in the 2 age groups. | 16714005 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type 2 diabetes mellitus. | 16714840 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity and insulin resistance in both Japanese type 2 diabetes patients and non-diabetic subjects. | 16714840 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | An increase in the number of risk factors for metabolic syndrome was highly correlated with an increased baPWV, probably due to insulin resistance. | 16715651 |
| Increased insulin level, "Alzheimers Disease", Data types - Address, Memory impairment | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are risk factors for memory impairment and Alzheimer disease (AD). | 16717209 |
| Malabsorption Syndrome, diabetic | Deregulated Nutrient Sensing | To investigate non-invasively the incidence of absorption of carbohydrates in diabetic patients during an oral glucose tolerance test (OGTT) and to determine whether malabsorption may be associated with insulin secretion and insulin resistance. | 16718794 |
| Malabsorption Syndrome | Deregulated Nutrient Sensing | Insulin resistance may be overestimated by using these markers if the patient has carbohydrate malabsorption, or that carbohydrate malabsorption may be present prior to the development of insulin resistance. | 16718794 |
| Malabsorption Syndrome | Deregulated Nutrient Sensing | Hence carbohydrate malabsorption should be taken into account for estimating insulin resistance and beta-cell function. | 16718794 |
| Obesity | Deregulated Nutrient Sensing | In AS, severe childhood obesity, waist circumference, and body fat decrease with age, whereas insulin resistance increases. | 16720663 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Aging is associated with insulin resistance, primarily as a result of physical inactivity and increased abdominal obesity. | 16720745 |
| Hypercholesterolemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. | 16728551 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We investigated the effect of testosterone treatment on insulin resistance and glycaemic control in hypogonadal men with type 2 diabetes. | 16728551 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Testosterone replacement therapy reduces insulin resistance and improves glycaemic control in hypogonadal men with type 2 diabetes. | 16728551 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Low levels of testosterone in men have been shown to be associated with type 2 diabetes, visceral adiposity, dyslipidaemia and metabolic syndrome. | 16728551 |
| Heart Diseases, Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Cerebrovascular accident | Deregulated Nutrient Sensing | Coexistence of insulin resistance and inflammation effectively predicts cardiac disease but not stroke in Japanese patients with type 2 diabetes mellitus. | 16730841 |
| Inflammation, macroangiopathy | Deregulated Nutrient Sensing | It is well known that insulin resistance (IR) and inflammation (IF) are associated with macroangiopathy. | 16730841 |
| Toxic effect | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. | 16731822 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Epidemiological studies suggest that high body iron stores are associated with insulin resistance and type 2 diabetes. | 16732023 |
| Hyperglycemia, Cardiac complication, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hyperglycaemia in Type 2 diabetes has a major role in the development of microvascular complications, whereas the dyslipidaemia is the major cause of macrovascular complications. | 16732709 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In patients with Type 2 diabetes, activation of PPAR-alpha and PPAR-gamma with the fibrates and glitazones improves dyslipidaemia and increases insulin sensitivity, respectively. | 16732709 |
| Increased insulin level | Deregulated Nutrient Sensing | Obese children exhibited hyperinsulinemia and insulin resistance; however, trans fatty acid intake or their plasma levels were not associated with them. | 16733524 |
| Blood Glucose | Deregulated Nutrient Sensing | Overall, tight glycemic regulation is achieved in a broad critical care cohort with optimized insulin and nutrition delivery, effectively managing glycemia even with high effective insulin resistance. | 16734548 |
| Thalassemia | Deregulated Nutrient Sensing | Insulin resistance and beta cell function in chronically transfused patients of thalassemia major. | 16735760 |
| Increased insulin level, Splenomegaly, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance, compensated by hyperinsulinemia, sets in early even before the onset of frank diabetes mellitus and correlated well with age, chelation therapy and indicators of iron overload like total units of blood transfused, splenomegaly and serum ferritin. | 16735760 |
| Multiparity, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glyburide was more likely to fail in women diagnosed earlier in pregnancy, of older age and multiparity, and with higher fasting glucoses, suggesting that earlier glucose intolerance and a reduced capacity to respond to an insulin secretagogue may distinguish this group. | 16738156 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Adherence with follow-up, physician recommendations, and new diagnoses of diabetes, hypertension, and dyslipidemia. | 16739759 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was the most commonly encountered risk factor followed by dyslipidemia, diabetes mellitus, and obesity. | 16740438 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The effects of different doses of atorvastatin on plasma endothelin-1 levels in type 2 diabetic patients with dyslipidemia. | 16741040 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Twenty-nine type 2 diabetic patients with dyslipidemia were enrolled and randomly assigned to receive atorvastatin orally at 10 mg (A10; n = 10), 20 mg (A20; n = 10), or 40 mg (A40; n = 9) daily for 12 weeks. | 16741040 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The clinical significance of these biphasic lipid-independent statin effects is unknown and the present study suggests that 20 mg atorvastatin may have the best benefits in treating diabetic patients with dyslipidemia. | 16741040 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular disease had been diagnosed previously in 0.7% of workers, hypertension in 6.2%, diabetes in 1.2%, and dyslipidemia in 8.9%. | 16750139 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Retrospective review of sex differences in the management of dyslipidemia in coronary heart disease: an analysis of patient data from a Maryland-based health maintenance organization. | 16750470 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Statins effectively treat dyslipidemia and reduce the risk of CHD mortality. | 16750470 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The objective of this study was to evaluate the treatment of dyslipidemia in patients with CHD and determine if sex differences exist. | 16750470 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | A significant gap in dyslipidemia treatment in these CHD patients remained, particularly for women. | 16750470 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. | 16751189 |
| Alzheimers Disease | Deregulated Nutrient Sensing | In this study we report for the first time that promotion of the NAD+-dependent sirtuin, SIRT1-mediated deacetylase activity, may be a mechanism by which CR influences Alzheimer disease (AD)-type amyloid neuropathology. | 16751189 |
| Amyloid Neuropathies | Deregulated Nutrient Sensing | These results demonstrate for the first time a role for SIRT1 activation in the brain as a novel mechanism through which CR may influence AD amyloid neuropathology. | 16751189 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Kidney Diseases | Deregulated Nutrient Sensing | Type 2 diabetes mellitus in young people was associated with early onset nephropathy and dyslipidaemia (almost from diagnosis), thus suggesting the need for earlier diagnosis. | 16751833 |
| Immature, Dyslipidemias | Deregulated Nutrient Sensing | The presence of dyslipidemia was more prevalent among offspring adolescents of premature CAD patients, but it was responsive to nutritional intervention. | 16751940 |
| Atherosclerosis | Deregulated Nutrient Sensing | We previously showed that 3'-end haplotypes in the LPL gene influence atherosclerosis and insulin resistance. | 16755277 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | It should be implemented in cases that are aged over 40 with at least one additional risk such as hypertension, obesity, dyslipidemia. | 16756047 |
| Acute myocardial infarction | Deregulated Nutrient Sensing | Insulin resistance in nondiabetic patients with acute myocardial infarction. | 16757401 |
| Restenosis | Deregulated Nutrient Sensing | Recent studies have shown that insulin resistance (IR) is an independent predictor of early restenosis after coronary stenting. | 16757401 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine how these multiple roles may relate to insulin resistance, we studied the regulation of GSK-3 protein expression and phosphorylation in skeletal muscle and isolated adipocytes from nonobese healthy control (HC), obese control (OC), and obese type 2 diabetic (OT2D) subjects. | 16757548 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effect of chromium on the insulin resistance in patients with type II diabetes mellitus. | 16761396 |
| Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | The aim of the present study was to evaluate the effect of chromium on the insulin resistance in diabetic patients with type II diabetes mellitus. | 16761396 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Chromium included early in the complex therapy of diabetes is beneficial in the reduction of the degree of insulin resistance. | 16761396 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Dyslipidemia has become a common problem in HIV disease, especially in patients on combination antiretroviral (ARV) therapy. | 16770290 |
| Pain Distress Question, Small Fiber Neuropathy, Diabetes Mellitus | Deregulated Nutrient Sensing | Somatic cutaneous small sensory fiber neuropathy (SSFN) can be an early manifestation of impaired glucose tolerance and diabetes mellitus and/or insulin resistance among obese subjects and is often associated with pain, wound occurrence and impaired wound healing. | 16770330 |
| Chronic liver disease | Deregulated Nutrient Sensing | Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases. | 16771945 |
| Increased insulin level, Liver Cirrhosis | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are present in nearly all patients with liver cirrhosis. | 16771945 |
| Liver Dysfunction | Deregulated Nutrient Sensing | Elevated resistin may contribute to insulin resistance in advanced liver dysfunction. | 16771945 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Use of U-500 regular insulin by continuous subcutaneous insulin infusion in patients with type 2 diabetes and severe insulin resistance. | 16772195 |
| Diabetes Mellitus, Non-Insulin-Dependent, Failure (biologic function) | Deregulated Nutrient Sensing | To determine the safety and efficacy of U-500 regular insulin delivered by continuous subcutaneous insulin infusion (CSII) as treatment for patients with type 2 diabetes and severe insulin resistance (mean 24-hour insulin requirement, 1.46 U/kg daily) who had failure of previous insulin therapy with either multiple daily injection (MDI) regimens or CSII using U-100 insulin analogues. | 16772195 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The study group consisted of 9 patients with type 2 diabetes and severe insulin resistance with hemoglobin A1c (A1C) values that exceeded 7.0%. | 16772195 |
| Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Endogenous hyperinsulinemia, along with insulin resistance, is associated with hypertension. | 16772245 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Other underlying risk factors were diabetes mellitus, smoking, cardiovascular disease and dyslipidemia. | 16773973 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, in view of the strong association between type 2 diabetes and UA stone formation, it is proposed that UA nephrolithiasis may be added to the conditions that potentially are associated with insulin resistance. | 16775030 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impaired insulin secretion (IS) and insulin resistance (IR) play an essential role in the pathogenesis of type 2 diabetes mellitus. | 16776626 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalences of insulin resistance, dyslipidemia, hypertension and hyperglycemia were higher among higher WC categories for both men and women. | 16780737 |
| Tumor necrosis, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Tumour necrosis factor (TNF)alpha is implicated in the relationship between obesity and insulin resistance/ type 2 diabetes. | 16784178 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Insulin resistance, adipokines, and oxidative stress in nondiabetic, hypercholesterolemic patients: leptin as an 8-epi-prostaglandin F2alpha determinant. | 16784964 |
| Schizophrenia | Deregulated Nutrient Sensing | Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report. | 16786820 |
| Schizophrenia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | By direct measurement, this study provides evidence of insulin resistance and susceptibility to type 2 diabetes in patients with schizophrenia who are free of antipsychotic drugs. | 16786820 |
| Obesity | Deregulated Nutrient Sensing | ACS1 expression was negatively correlated with measures of insulin resistance and central obesity (ACS1 versus HOMA: r = -0.28, P<0.05; ACS1 versus WHR: r = -0.23, P<0.05), with an opposite trend for FATP4. | 16788709 |
| Angina Pectoris, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Hypertensive (finding) | Deregulated Nutrient Sensing | Out of 8780 ABPM recordings we identified 79 hypertensive patients (both genders) who suffered a first nonfatal ischemic event, either cerebrovascular (stroke or transient ischemic attack) (STR/TIA, n = 48) or coronary (myocardial infarction, angina or coronary bypass/PTCA) (COR, n = 31) and 223 control-hypertensive patients (CTR) without any events during the same period who were fully matched (at the time of ABPM) for age, gender, antihypertensive therapy, presence of dyslipidemia or diabetes, and casual blood pressure (BP), in the proportion of 1 STR/TIA to 3 CTR and 1 COR to 6 CTR. | 16789404 |
| Chronic heart failure, Cachexia, Congestive heart failure | Deregulated Nutrient Sensing | It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying substrate metabolism. | 16789974 |
| Dyslipidemias | Deregulated Nutrient Sensing | Sustained improvement of dyslipidaemia in HAART-treated patients replacing stavudine with tenofovir. | 16791015 |
| Dyslipidemias | Deregulated Nutrient Sensing | The substitution of tenofovir for stavudine causes a sustained improvement of dyslipidaemia. | 16791015 |
| Acromegaly, Cardiomyopathies, Cardiac complication, Glucose Intolerance (disease), Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Increased morbidity and mortality with acromegaly is associated with cardiovascular complications, hypertension, glucose intolerance, cardiomyopathy and coronary artery disease. | 16793566 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | [Association of serum leptin and insulin resistance with nonalcoholic fatty liver disease]. | 16793619 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Increased leptin level, HOMA-IR, BMI and dyslipidemia can be important risk factors of NAFLD, and serum leptin level and HOMA-IR are positively correlated with the severity of NAFLD. | 16793619 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Hyperparathyroidism, Primary | Deregulated Nutrient Sensing | Dyslipidemia, hypertension, diabetes mellitus and also primary hyperparathyroidism (pHPT) are associated with an increased risk of cardiovascular diseases. | 16793947 |
| Acromegaly | Deregulated Nutrient Sensing | Effects of the long-acting somatostatin analogue Lanreotide Autogel on glucose tolerance and insulin resistance in acromegaly. | 16793952 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Almost the half (41 %) was diabetic, and 27 % had dyslipidemia. | 16796409 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We hypothesized that the combination of TZD+fibrate may be better than the sulfonylurea + statin approach regarding modifying the adipokine profile in diabetic patients with dyslipidemia. | 16799399 |
| Dyslipidemias, Obesity, diabetic | Deregulated Nutrient Sensing | In a survey of 98 consecutive admissions of diabetic patients, <40% had a MS; this is a low value compared to younger diabetic adults, due to a low prevalence of obesity and dyslipidemia. | 16799400 |
| Overweight | Deregulated Nutrient Sensing | Surrogate indexes vs. euglycaemic-hyperinsulinemic clamp as an indicator of insulin resistance and cardiovascular risk factors in overweight and obese postmenopausal women. | 16799402 |
| Overweight | Deregulated Nutrient Sensing | Surrogate measures of insulin resistance, in particular fasting insulin, are simple tools appropriate for epidemiological studies that can be used as substitutes for the EH clamp to estimate glucose disposal and cardiovascular risk factors in overweight and obese postmenopausal women. | 16799402 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease. | 16799888 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver diseases are often associated with obesity, insulin resistance, and excessive visceral fat accumulation. | 16799888 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The severity of fatty liver was positively correlated with visceral fat accumulation and insulin resistance in both obese and nonobese subjects, suggesting that hepatic fat infiltration in nonalcoholic fatty liver disease may be influenced by visceral fat accumulation regardless of body mass index. | 16799888 |
| Hypogonadism, Hypothyroidism | Deregulated Nutrient Sensing | The prevalence of hypothyroidism in splenectomized patients was significantly higher (P = 0.005), whereas the presence of hypogonadism, impaired glucose homeostasis and insulin resistance, although more frequent, was not statistically significant. | 16800840 |
| Fatty Liver, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in a group of obese children (BMI > 97th %) and to establish correlations between the severity of hepatic fatty infiltration, auxological findings and parameters of insulin resistance. | 16801180 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | Although studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse. | 16801582 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). | 16801588 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. | 16801590 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our study supports the hypothesis that adult markers of prepubertal growth, especially leg length-to-height ratio, are associated with adiposity, insulin resistance, and type 2 diabetes in the general U.S. population. | 16801590 |
| Dyslipidemias | Deregulated Nutrient Sensing | In patients on hemodialysis, dyslipidemia is generally characterized by increased concentrations of LDL cholesterol and triglycerides, and a decreased concentration of HDL cholesterol, as also confirmed by our study. | 16802568 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Recently it was reported that adipokines are closely associated with the common risk factors for NAFLD, such as obesity, diabetes, dyslipidemia, and insulin resistance. | 16804347 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The risk factors found were Hypertension in 37 (80.4%) of patients, diabetes in 16 (34.8%), and Dyslipidaemia in 20 (43.5%). | 16805167 |
| Hypoadiponectinemia, Atherosclerosis | Deregulated Nutrient Sensing | Present and further clinical relevant to atherosclerosis in this patient should be imformative concerning the pathogenesis and treatment of atherosclerosis in the presence of hypoadiponectinemia and insulin resistance. | 16806559 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Insulin resistance, growth factors and cytokine levels in overweight women with breast cancer before and after chemotherapy. | 16807226 |
| Breast Carcinoma | Deregulated Nutrient Sensing | To evaluate insulin values, insulin resistance, growth factors and cytokine levels in women suffering from breast cancer and the effect of chemotherapy on these parameters. | 16807226 |
| Apolipoprotein E, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polymorphism of the apolipoprotein E (APOE) gene has been associated with dyslipidemia and cardiovascular disease. | 16815257 |
| Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular diseases are more common in renal transplant recipients than in the general population, and a number of 'traditional' risk factors, such as smoking, diabetes mellitus and dyslipidaemia, are known to be associated with an increased risk. | 16815854 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increasingly strong links are being recognized between diabetes, insulin resistance and liver fat accumulation [e.g. | 16817817 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The results suggest that glucosamine ingestion may affect glucose levels and consequent glucose uptake in patients who have untreated diabetes or glucose intolerance. | 16818461 |
| Obesity, Visceral | Deregulated Nutrient Sensing | [The relationship between testosterone and dehydroepiandrosterone sulfate concentrations, insulin resistance and visceral obesity in elderly men]. | 16821208 |
| Increased insulin level, Hypercholesterolemia, metabolic disturbance | Deregulated Nutrient Sensing | In these men also changes of body composition (visceral obesity, increasing of fat mass), and metabolic disturbances (hypercholesterolemia, hyperinsulinism and insulin resistance) are common disorders. | 16821208 |
| Testosterone Deficiency, CTCAE, Obesity, Visceral | Deregulated Nutrient Sensing | Visceral obesity and insulin resistance may be either reasons or effects of testosterone deficiency. | 16821208 |
| Testosterone Deficiency, CTCAE, Obesity, Visceral | Deregulated Nutrient Sensing | Probably also DHEA-S deficiency is the risk factor of visceral obesity and insulin resistance, but it is not clear, whether this possible influence is independent from testosterone deficiency. | 16821208 |
| Obesity | Deregulated Nutrient Sensing | DHEA-S and testosterone deficiency were independently associated with higher insulin resistance and obesity. | 16821208 |
| Coronary heart disease | Deregulated Nutrient Sensing | [Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease--preliminary study]. | 16821209 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The aim of this study was to analyze the influence of DHEA therapy on insulin resistance (FIRI, FG/FI) and serum lipids in men with angiographically verified coronary heart disease (CHD). | 16821209 |
| Dyslipidemias, Hypertension, CTCAE, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | Obesity, hypertension, and dyslipidemia are the major factors associated with hyperuricemia in this study. | 16821269 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Physicians should be aware of the possibility of dyslipidemia, particularly hypertriglyceridemia, following treatment with capecitabine. | 16821596 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Targeting insulin resistance in type 2 diabetes patients suboptimally controlled with insulin. | 16822926 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Multiple cardiovascular risks (dyslipidemia, hypertension, and diabetes) are addressed. | 16823999 |
| Complications of Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Lack of association between the Pro12Ala polymorphism in PPAR-gamma2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes. | 16824933 |
| Increased insulin level, Overweight, Pre-Eclampsia | Deregulated Nutrient Sensing | It is controversial whether insulin resistance (IR) is present in preeclamptic patients, and it is unclear if hyperinsulinemia is dependent upon being overweight during pregnancy or on preeclampsia per se. | 16824935 |
| Hyperlipidemia, Thrombosis, Inflammation, Hyperglycemia, Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | Unexpectedly, evidence was developed that four major attributes of sympathetic activation represent four major risk factors; attributes of sympathetic activation are a tendency toward thrombosis and vasoconstriction, lipidemia, inflammation, and hyperglycemia, and corresponding risk factors are endothelial dysfunction (which expresses thrombosis/vasoconstriction and epitomizes this tendency), dyslipidemia, inflammation, and insulin resistance. | 16828234 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | These findings, plus other information, provide evidence that dyslipidemia acts mainly as a marker of risk of IHD, rather than being the basic mechanism of this disorder. | 16828234 |
| Thrombosis, Atherosclerosis, Dyslipidemias, Infarction, atherosclerotic | Deregulated Nutrient Sensing | It seems generally accepted that dyslipidemia results rather automatically in infarction through the sequence of atherosclerosis, atherosclerotic complications, and thrombosis. | 16828234 |
| Metabolic Diseases, Somatotropin deficiency | Deregulated Nutrient Sensing | Insulin resistance may play a role in glucose and lipid metabolism disorders associated with GHD. | 16829702 |
| Alopecia | Deregulated Nutrient Sensing | Association of insulin resistance linked diseases and hair loss in elderly men. | 16830609 |
| Androgenetic Alopecia, Myocardial Ischemia | Deregulated Nutrient Sensing | Previous investigations have shown an association of androgenetic alopecia (AGA) with insulin resistance related disorders such as ischemic heart disease. | 16830609 |
| Blood Glucose | Deregulated Nutrient Sensing | Additionally, other measures of glycemia and insulin resistance also dose-dependently increased with increasing fasting and post-load glucose levels (p<0.001 for all). | 16840831 |
| Angina Pectoris, Cardiovascular Diseases, Blood Glucose, Coronary heart disease, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance is clearly associated with increasing risk of cardiovascular disease, but the association among increasing glycemia and cardiovascular risk factors, angina and coronary heart disease in normoglycemic subjects is less clear, particularly in Chinese. | 16840831 |
| Organ Dysfunction Scores | Deregulated Nutrient Sensing | A growing body of animal and human data has correlated insulin resistance with organ dysfunction. | 16843864 |
| Biliary calculi, Gallbladder | Deregulated Nutrient Sensing | These data suggest that in lean, nondiabetic volunteers without gallstones, gallbladder dysmotility is associated with an elevated fasting glucose as well as a high index of insulin resistance. | 16843864 |
| Gallbladder, Biliary calculi, Acalculous Cholecystitis | Deregulated Nutrient Sensing | We conclude that insulin resistance alone may be responsible for gallbladder dysmotility that may result in acalculous cholecystitis or gallstone formation. | 16843864 |
| Peripheral Vascular Diseases, Dyslipidemias, Diabetes Mellitus, Congestive heart failure | Deregulated Nutrient Sensing | The frequency of diabetes, congestive heart failure, peripheral vascular disease, and dyslipidemia were common, but not different between groups. | 16844637 |
| Bipolar Disorder, Hostility | Deregulated Nutrient Sensing | The severity of depressive symptoms, hostility, and anger expression was positively associated with estimated insulin resistance (IR) and insulin in women but not in men. | 16846323 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and declining beta-cell function are the core defects in type 2 diabetes mellitus. | 16846554 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | The correlation of insulin resistance and renal function in non diabetic chronic kidney disease patients. | 16858947 |
| Injury of kidney | Deregulated Nutrient Sensing | A greater degree of insulin resistance may predispose to renal injury by worsening renal hemodynamics through the elevation of glomerular filtration fraction. | 16858947 |
| Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | However, there are sparse data on the relationship between insulin resistance, glomerular filtration rate (GFR) and body composition in chronic kidney disease (CKD) without diabetes. | 16858947 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | In non-diabetic CKD patients, the independent factor for insulin resistance was the amount of total body fat. | 16858947 |
| Lipodystrophy | Deregulated Nutrient Sensing | Lipodystrophy, an altered development and/or repartition of body fat, is associated with alterations of lipid and glucose metabolism with insulin resistance. | 16860281 |
| diabetic | Deregulated Nutrient Sensing | [The influence hypocaloric diet in insulin resistance, functional active beta-cell and metabolism lipids in type 2 diabetic patients]. | 16862952 |
| diabetic | Deregulated Nutrient Sensing | It was investigated the influence of traditional hypocaloric diet on dynamic of glucaemia, insulin resistance, beta-cell function, lipid peroxidation, level of hormone resistin and enzymes of antioxidant system in type 2 diabetic patients. | 16862952 |
| diabetic | Deregulated Nutrient Sensing | Our results show that diet therapy improves metabolic control in type 2 diabetic patients, and as a result of a diet were normoglucaemia, decrease of insulin resistance, lipid peroxidation, but also decrease of enzymes of antioxidant system and moderate decrease of beta-cell function. | 16862952 |
| Overweight, Obesity | Deregulated Nutrient Sensing | However, by multiple logistic regression, female gender, overweight and obesity, and elevated WBC count were all found to be independent risk factors of insulin resistance, but age, RBC and platelet counts were not. | 16863009 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects. | 16865358 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | This polymorphism has been studied in relation to insulin resistance, type 2 diabetes and obesity in several populations with conflicting results. | 16865358 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | No significant associations with type 2 diabetes or related quantitative metabolic traits, including measures of insulin resistance, were detected. | 16865358 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin-resistance (IR), type 2 diabetes (T2D) and a constellation of cardiovascular risk factors at the early years of life. | 16868146 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance. | 16868148 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The ACAA-insertion/deletion polymorphism at the 3' UTR of IGFIIR is associated with type 2 diabetes and influences surrogate markers of insulin resistance in non-diabetic subjects. | 16868148 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that whereas chronic dyslipidemia associated with elevated triglycerides may reduce auditory function, short-term dietary changes may not. | 16868509 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | A simple lifestyle advice program significantly improves insulin resistance, and the liver disease in pediatric NAFLD. | 16871574 |
| Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Heart Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of complications was estimated using the 2nd assumption, as was the prevalence of hypertension, dyslipidemia, Ischemic Heart Disease (IHD) and stroke in the non-diabetic population in 2014. | 16871830 |
| Data types - Address, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | We extended this line of research by attempting to correlate the deficits in insulin/IGF signaling and energy production with mitochondrial dysfunction, oxidative injury, and compensatory cyto-protective responses in brains with different Braak Stage severities of AD. | 16873964 |
| Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | In untreated individuals, a significant interaction was observed between obesity and insulin resistance as related to FPRNa (P = 0.002): the highest age-adjusted levels of FPRNa were detected in obese hypertensive and obese insulin-resistant participants. | 16877967 |
| Asthma, Dyslipidemias, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common co-morbidity was diabetes mellitus, found in 98 (38.4%), followed by dyslipidemia in 50 (19.6%), bronchial asthma in 28 (11.0%) and renal diseases in 12 (4.7%). | 16883084 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | GH peak response to GHRH-arginine and cardiovascular risk factors, including obesity, insulin resistance, low levels of high density lipoprotein (HDL) cholesterol, elevated triglycerides, and hypertension. | 16886956 |
| Dyslipidemias | Deregulated Nutrient Sensing | Contemporary management of dyslipidemia in high-risk patients: targets still not met. | 16887414 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Cutoff values of surrogate measures of insulin resistance for metabolic syndrome in Korean non-diabetic adults. | 16891815 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | Thus, in general, it augments glucose intolerance in diabetic patients. | 16891829 |
| Persian language, Obesity | Deregulated Nutrient Sensing | The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. | 16894240 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Cranial irradiation was strongly related to GH deficiency, and in turn lower insulin-like growth factor 1 (IGF-1), higher fasting insulin, abdominal obesity, and dyslipidemia, particularly in women. | 16894525 |
| Hypogonadism | Deregulated Nutrient Sensing | [Hypogonadism may cause insulin resistance in young males]. | 16894938 |
| Hypogonadism | Deregulated Nutrient Sensing | (2) HOMA-IR and fast insulin levels were significantly higher in the hypogonadism group than in the control, which suggests that lower serum testosterone may cause insulin resistance in young male patients. | 16894938 |
| Hyperglycemia, Critical Illness, Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperglycemia and insulin resistance frequently occur in critically ill patients even without a history of diabetes. | 16895955 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Although the VPSO group resembled the PCOS group in their 17PROG response to the GnRHag test, they differed in having significantly smaller ovaries and lower body mass index and in lacking evidence of peripheral androgen excess and of insulin resistance. | 16895960 |
| Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes of short duration with insulin use conferred a substantially elevated risk for pancreatic cancer and may reflect insulin resistance that is elicited by pancreatic cancer. | 16896032 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Efficacy and safety of coadministered amlodipine and atorvastatin in patients with hypertension and dyslipidemia: results of the AVALON trial. | 16896273 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Concomitant administration of amlodipine and atorvastatin is an effective and well tolerated treatment for coexisting hypertension and dyslipidemia. | 16896273 |
| Dyslipidemias, Retinal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | An accumulation of certain genotypes of candidate genes for diabetes mellitus type 2 is associated with the severity of dyslipidemia and microvascular late complications, e.g., grade of retinopathy. | 16896567 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | Insulin resistance differed substantially between lean (BMI < 25 kg/m2), overweight or obese (BMI > or = 25 kg/m2), and type 2 diabetic individuals. | 16899806 |
| Overweight, Obesity | Deregulated Nutrient Sensing | In conclusion, a superior fasting-based index estimate to distinguish between the presence and absence of insulin resistance in overweight and obesity could not be identified despite the use of the large datasets. | 16899806 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Menopause, insulin resistance, and risk factors for cardiovascular disease. | 16900080 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease. | 16901766 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | An association between nonalcoholic fatty liver disease (NAFLD) and the insulin resistance (IR) syndrome exists. | 16901766 |
| HIV Infections, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine factors associated with diabetes, insulin resistance, and abnormal glucose tolerance in older men with or at risk of HIV infection. | 16903984 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance. | 16911630 |
| diabetic | Deregulated Nutrient Sensing | In addition, within the group of diabetic patients, the TT genotype was commoner in subjects with increased homeostasis model assessment (HOMA) index for insulin resistance. | 16911630 |
| diabetic | Deregulated Nutrient Sensing | Moreover, within the diabetic subjects, this CD36 snp was associated with insulin resistance (HOMA index). | 16911630 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. | 16913878 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | We explored the relations of leukocyte telomere length, expressed by terminal restriction fragment (TRF) length, with insulin resistance, oxidative stress and hypertension. | 16913878 |
| Hypertension, CTCAE, Antihypertensive Agents | Deregulated Nutrient Sensing | Collectively, these observations suggest that hypertension, increased insulin resistance and oxidative stress are associated with shorter leukocyte telomere length and that shorter leukocyte telomere length in hypertensives is largely due to insulin resistance. | 16913878 |
| Heart failure | Deregulated Nutrient Sensing | The aim of this study was to investigate the hemodynamic response to the beta-adrenergic agonist isoproterenol and to identify molecular deficiencies that may be predictive of cardiac failure in a low-birth weight rodent model that develops insulin resistance and type 2 diabetes in adulthood. | 16914429 |
| Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Obesity, Erectile dysfunction, Hypertension, CTCAE, atherosclerotic | Deregulated Nutrient Sensing | Erectile dysfunction (ED) is associated with clinical atherosclerosis and several atherosclerotic risk factors including smoking, hypertension, dyslipidemia, diabetes mellitus, obesity and sedentary lifestyle. | 16915303 |
| Inflammation, Thrombosis, Dyslipidemias | Deregulated Nutrient Sensing | We conclude that selected biomarkers for endothelial function, thrombosis and dyslipidemia but not inflammation are associated with the degree of ED in this cross-sectional analysis. | 16915303 |
| Thrombus, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and thrombotic processes are both clearly involved in atherogenesis and its secondary complications. | 16916537 |
| Apolipoproteins B | Deregulated Nutrient Sensing | Moreover, increasing CRP concentration in this paediatric population was associated with an enhanced CV risk profile, consisting of increased adiposity, higher insulin resistance, worsening lipid profile (higher total cholesterol, triglycerides, low-density lipoprotein cholesterol, apolipoprotein B and total cholesterol : high-density-lipoprotein cholesterol ratio), increased leptin and decreased adiponectin. | 16918582 |
| Hyperglycemia | Deregulated Nutrient Sensing | In conclusion, the present study suggested that the A/L ratio might be more useful than HOMA-R to accurately assess insulin resistance in subjects without hyperglycemia. | 16919546 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Inadequate treatment of dyslipidemia in people with type 2 diabetes: quality assessment of diabetes care in a Danish County. | 16923628 |
| NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial | Deregulated Nutrient Sensing | Human SIRT1 (hSIRT1) repression of DHT-induced AR signaling requires the NAD-dependent catalytic function of hSIRT1 and the AR lysine residues deacetylated by SIRT1. | 16923962 |
| Prostate carcinoma | Deregulated Nutrient Sensing | DHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins. | 16923962 |
| Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | While hs-CRP associates with insulin resistance and subclinical atherosclerosis in ealy-state type 2 diabetes, our data suggest that hs-CRP is a useful marker of subclinical atherosclerosis in early-state type 2 diabetes mellitus independent of factors that directly reflect insulin resistance. | 16926521 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. | 16936218 |
| Colorectal Carcinoma, Structure of beta Cell of islet, Hyperinsulinism, Diabetes Mellitus | Deregulated Nutrient Sensing | The neoplastic process in the colon is not associated with hyperinsulinaemia or insulin resistance, but in CRC patients, pancreatic B-cell dysfunction typical of the early stages of diabetes is seen. | 16938722 |
| Atherosclerosis | Deregulated Nutrient Sensing | This was a population-based, prospective cohort study (the Atherosclerosis and Insulin Resistance study) conducted in Goteborg, Sweden, among 313 Caucasian men without cardiovascular or other clinically overt diseases. | 16940451 |
| Communicable Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression. | 16941280 |
| Obesity | Deregulated Nutrient Sensing | However, more recent data suggest that low androgen levels are associated with adverse cardiovascular risk factors, including an atherogenic lipid profile, obesity and insulin resistance. | 16943795 |
| Dyslipidemias, Diabetes Mellitus, Thyroid Diseases, Nephrotic Syndrome, Obesity, Kidney Failure | Deregulated Nutrient Sensing | The exclusion criteria were renal failure, nephrotic syndrome, thyroid or liver disease, diabetes mellitus, obesity, pregnancy and taking drugs that induce dyslipidemia. | 16944155 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Since dyslipidemia is common in diabetes and is associated with increased cardiovascular risk, we tested the hypothesis that Thr-54 is associated with increased cardiovascular risk in patients with diabetes. | 16945373 |
| Inflammation, Restenosis | Deregulated Nutrient Sensing | Insulin resistance or inflammation is known to be related with lipoprotein lipase activity and these factors are also closely associated with the pathogenesis of bare-metal stent restenosis. | 16948449 |
| Dyslipidemias | Deregulated Nutrient Sensing | These modifications are independent of the degree of dyslipidemia and may represent an indicator of reduced cardiovascular risk. | 16948972 |
| Glucose Intolerance (disease), Hepatocellular Adenoma | Deregulated Nutrient Sensing | Hepatic adenomatosis in a young woman with glucose intolerance. | 16951669 |
| Alcoholic Intoxication, Chronic, Dyslipidemias, Sedentary, Smoking, Diabetes Mellitus, Coronary heart disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Personal antecedents for coronary disease (smoking, dyslipidemia, diabetes mellitus, arterial hypertension, family antecedents, sedentarism, and alcoholism) were analyzed. | 16951828 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | Insulin resistance and hypoadiponectinemia were found in these MS children. | 16953257 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | This case report suggests that the incretin mimetic exenatide decreases hepatic fat accumulation and may play a role in the future treatment of NAFLD, and the associated insulin resistance and cardiovascular risk factors in an ever-growing high-risk population. | 16953843 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We concluded that isoprostanes may not be causally involved in the development of glucose intolerance, insulin resistance or deteriorating BCF. | 16956690 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Isoprostanes, a marker of lipid peroxidation, may not be involved in the development of glucose intolerance. | 16956690 |
| Glucose Intolerance (disease), Hepatitis C | Deregulated Nutrient Sensing | In conclusion, this community based study has shown that in a single population, chronic HCV infection is associated with glucose intolerance and, despite that, a favourable lipid pattern. | 16956918 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Overweight, hypertension, dyslipidemia (men only), smoking (men only), and diabetes (women only) contributed significantly to elevated hs-CRP levels. | 16963054 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Overweight individuals with hypertension, dyslipidemia, and diabetes had a high prevalence of elevated hs-CRP levels in both sexes. | 16963054 |
| Hypertensive disease, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Medical conditions such as coronary artery disease, arterial hypertension, and dyslipidemia did not diminish this recovery. | 16964557 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer. | 16965239 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | We investigated interactions between foods (dairy products, red and processed meat, and whole and refined grains) and dietary patterns (sucrose-to-fiber ratio and glycemic index) associated with insulin resistance with the FokI polymorphism of the VDR gene and colon and rectal cancer risk. | 16965239 |
| Postmenopausal state, Breast Carcinoma | Deregulated Nutrient Sensing | These results suggest a reduction in breast cancer risk for women with insulin resistance syndrome who consume high-fat diets and no association between specific sources of fat during midlife and risk of postmenopausal breast cancer. | 16968865 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | An unchanged or increased GGT level over time, even when GGT is in the normal range, is correlated with increasing insulin resistance and is associated with a risk of incident type 2 diabetes in both sexes, independently of baseline GGT, which is itself a diabetes risk factor. | 16969645 |
| Electrocardiogram: left ventricle hypertrophy (finding), Obesity | Deregulated Nutrient Sensing | Insulin resistance and fasting insulin is not associated with left ventricular hypertrophy in healthy people, independent of obesity. | 16970048 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Long-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetes. | 16970952 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Development of insulin resistance (IR) and the progressive failure of the pancreatic beta-cell function (BCF) may be important in the pathogenesis of type 2 diabetes. | 16970952 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Similarly, of all subjects with hypertension, 29.1% had diabetes (known or newly diagnosed) and 43.0% had glucose intolerance of some form. | 16978379 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance and type 2 diabetes are linked to increased TNF-alpha action. | 16979382 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma DS-TNFR2 concentration was significantly decreased among patients with glucose intolerance or type 2 diabetes mellitus (p=0.026). | 16979382 |
| Dyslipidemias, Disease of capillaries, Diabetes Mellitus, macroangiopathy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 1 diabetes is associated with a favorable lipid pattern and with microangiopathy, which is not true for type 2 diabetes, which is related to dyslipidemia and macroangiopathy. | 16981430 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Androgen deprivation therapy with a gonadotropin-releasing hormone (GnRH) agonist is associated with increased fat mass and insulin resistance in men with prostate cancer, but the risk of obesity-related disease during treatment has not been well studied. | 16983113 |
| Coronary Artery Disease, Left ventricular ejection fraction | Deregulated Nutrient Sensing | Myocardial insulin resistance (IR) is a feature of coronary artery disease (CAD) with reduced left ventricular ejection fraction (LVEF). | 16984986 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | A total of 151 middle-aged men and women, with hypertension, dyslipidemia, type 2 diabetes, or obesity were enrolled. | 16990155 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia and insulin resistance (IR) are risk factors for coronary heart disease (CHD) in adults. | 16990559 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Using either criterion, diabetes was identified in 265 (9.6%) subjects and glucose intolerance in 568 (20.5%) subjects. | 16990663 |
| Dyslipidemias | Deregulated Nutrient Sensing | Additionally, Cpn seropositivity was significantly associated with dyslipidemia and elevated IL-6, known risk factors for CAD. | 17000560 |
| Hypotension, CTCAE, Dyslipidemias, Kidney Failure, Cervical Intraepithelial Neoplasia | Deregulated Nutrient Sensing | On univariate logistic analysis, age, pre-existing renal insufficiency, intra-aortic balloon pump (an indirect indicator of haemodynamic instability), dyslipidaemia, and postprocedural hypotension were risk indicators for the development of CIN after primary PCI. | 17001234 |
| Hypothyroidism | Deregulated Nutrient Sensing | Although insulin resistance in thyroid hormone excess is well documented, information on insulin action in hypothyroidism is limited. | 17003097 |
| Lipodystrophy, deficiency aspects, Fatty Liver | Deregulated Nutrient Sensing | Lipin deficiency causes lipodystrophy, fatty liver, and insulin resistance in mice, whereas adipose tissue lipin overexpression results in increased adiposity but improved insulin sensitivity. | 17003347 |
| Obesity | Deregulated Nutrient Sensing | Lipin expression in skeletal muscle, however, was not related to obesity or insulin resistance. | 17003347 |
| Inflammation, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | The ramifications of these findings with respect to insulin resistance, sympathetic tone, inflammation and hypertension, often associated with pathologic atrial fibrillation, are discussed. | 17005327 |
| Kidney Failure, Chronic, Atherosclerosis | Deregulated Nutrient Sensing | Despite the favourable effects of adiponectin on the vasculature and insulin resistance (IR), levels are increased in patients with end-stage kidney disease (ESKD), in whom both IR and atherosclerosis are prevalent. | 17005524 |
| Glucose Intolerance (disease), Liver diseases, Peripheral Neuropathy, Hyperuricemia | Deregulated Nutrient Sensing | One patients had the complication of central and peripheral neuropathy, One patients had the complication of glucose intolerance, One patients had the complication of chronic hepatopathy and hyperuricaemia. | 17007380 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone. | 17007957 |
| atherosclerotic | Deregulated Nutrient Sensing | Insulin resistance is related to the atherosclerotic process. | 17007957 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this study, we examined the association between endothelial function and insulin resistance in 48 subjects with type 2 diabetes. | 17007957 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | There is a significant association between vascular endothelial dysfunction and insulin resistance in type 2 diabetes. | 17007957 |
| Glucose Intolerance (disease), Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This increase in association with other cardiovascular risk factors that include dyslipidemia, insulin resistance, glucose intolerance, type II diabetes mellitus, suggest the necessity of accurate prevention strategies. | 17008856 |
| Cardiovascular morbidity, Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Patients with dyslipidemia and advanced renal failure are at markedly increased risk of cardiovascular morbidity and mortality. | 17009078 |
| Endothelial dysfunction, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | It has been postulated that high serum concentrations of adiponectin, an emerging biomarker that is linked to insulin resistance and endothelial dysfunction, may be protective against T2DM and CHD. | 17010797 |
| Hostility | Deregulated Nutrient Sensing | Hostility and urine norepinephrine interact to predict insulin resistance: the VA Normative Aging Study. | 17012525 |
| Hostility | Deregulated Nutrient Sensing | Previous research has produced mixed results pertaining to the association between hostility and insulin resistance. | 17012525 |
| Hostility | Deregulated Nutrient Sensing | We hypothesized that hostility may interact with circulating norepinephrine (NEPI) levels, indexed by 24-hour urine concentrations, to affect insulin resistance. | 17012525 |
| Hostility | Deregulated Nutrient Sensing | Individuals with high stress and high hostility were more likely to have insulin resistance. | 17012525 |
| Overweight | Deregulated Nutrient Sensing | Although markedly overweight, the glucose tolerance was normal and insulin levels indicated no remarkable insulin resistance on the 75 g oral glucose tolerance test. | 17016000 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Obese patients, particularly the class III obese, were significantly younger and had higher prevalence of diabetes, hypertension, and dyslipidemia (P < 0.0001). | 17020562 |
| Hyperlipidemia, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | The obese children were studied according to coexistence of hypertension, hyperlipidemia, positive family history of cardiovascular diseases and insulin resistance. | 17020652 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It is hypothesized that proinflammatory cytokines contribute to atherogenesis, peripheral insulin resistance, and the development of hypertension and type II diabetes. | 17021763 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance plays an important role in the development of obesity. | 17026496 |
| No metabolic abnormalities, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and associated metabolic abnormalities occur more commonly in the overweight/obese, and these changes increase the risk of cardiovascular disease (CVD). | 17027570 |
| Hypertensive (finding), Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | More than half (51%) were hypertensive, whereas 28% had dyslipidemia, 56% were past or current smokers, and 6% had diabetes. | 17027581 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our objective was to delineate the potential role of adipogenesis in insulin resistance and type 2 diabetes. | 17030965 |
| Overweight | Deregulated Nutrient Sensing | The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. | 17031391 |
| Overweight | Deregulated Nutrient Sensing | To evaluate if CLA as a mixture of the main isomers trans-10 cis-12 and cis-9 trans-11 affects the insulin resistance in healthy overweight and obese male and female adults. | 17031391 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | The suggested correlation between a T-to-C transition at the nucleotide 16189 in mitochondrial DNA (mtDNA) with increasing insulin resistance and adult-onset diabetes mellitus (DM) is debatable. | 17032725 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | OSAS is associated with reduced levels of adiponectin independently of insulin-resistance and BMI. | 17033258 |
| Hypertension, CTCAE, Peripheral Arterial Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | To avoid confounding factors, conditions known to affect endothelial function like diabetes mellitus, hypertension, dyslipidemia, smoking, coronary and peripheral artery disease were excluded from both groups. | 17036158 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Actually, 35% of all AMI patients do not survive the first day after acute onset and in up to 90% of them classic risk factors (hypertension, dyslipidemia, diabetes, cigarette smoking) were present. | 17039323 |
| Hyperglycemia, Obesity | Deregulated Nutrient Sensing | Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. | 17040956 |
| Obesity | Deregulated Nutrient Sensing | Resistin is a newly identified adipocytokine which has demonstrated links between obesity and insulin resistance in rodents. | 17040961 |
| Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding), Obesity | Deregulated Nutrient Sensing | Sex-related differences in the relations of insulin resistance and obesity to left ventricular hypertrophy in Japanese hypertensive patients. | 17044662 |
| Left Ventricular Hypertrophy, Obesity | Deregulated Nutrient Sensing | Both insulin resistance and obesity have a well-known association with LV hypertrophy. | 17044662 |
| Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | We enrolled 91 never-treated hypertensive patients (49 men and 42 women) to assess the possible relations of insulin resistance and obesity to LV geometry. | 17044662 |
| Left Ventricular Hypertrophy, Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | In conclusion, these findings indicate the presence of sex-related differences in the relations of insulin resistance and obesity to LV hypertrophy in Japanese hypertensive patients. | 17044662 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of dyslipidemia in non-obese prepubertal children and its association with family history of diabetes, high blood pressure, and obesity. | 17045120 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Because obesity masks the need for screening, there is no previous description of dyslipidemia in healthy normal-weight children. | 17045120 |
| Nonesterified Fatty Acids Measurement, Cardiomyopathy, Familial Idiopathic, Ventricular Dysfunction | Deregulated Nutrient Sensing | Decreased myocardial free fatty acid uptake in patients with idiopathic dilated cardiomyopathy: evidence of relationship with insulin resistance and left ventricular dysfunction. | 17045185 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance, a common comorbidity in heart failure patients, and medical therapy may modify myocardial metabolism in complex fashions. | 17045185 |
| Cardiomyopathy, Familial Idiopathic | Deregulated Nutrient Sensing | Therefore, we characterized myocardial oxidative and free fatty acid (FFA) metabolism in patients with idiopathic dilated cardiomyopathy (IDCM) and investigated the contributions of insulin resistance and beta-blocker therapy. | 17045185 |
| Depressed mood | Deregulated Nutrient Sensing | However, when LV function is further depressed and insulin resistance manifested, myocardial FFA uptake and oxidation are, in turn, upregulated. | 17045185 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | Hypoadiponectinemia is significantly associated with cardiovascular risk factors such as insulin resistance and atherogenic lipid profiles in nonobese, apparently healthy subjects. | 17046559 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Adiponectin levels are significantly lower in obese adult patients with type 2 diabetes mellitus, essential hypertension, dyslipidemia, and cardiovascular disease. | 17046559 |
| Obesity | Deregulated Nutrient Sensing | A common genetic background contributes to the clustering of different MSX component traits and central obesity or insulin resistance. | 17047637 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus. | 17048191 |
| Overweight | Deregulated Nutrient Sensing | Insulin resistance, oxidative stress markers and the blood antioxidant system in overweight elderly men. | 17050115 |
| Hyperglycemia | Deregulated Nutrient Sensing | It was indicated that the increased insulin resistance and hyperglycemia in elderly men are related to body mass and that they cause intensified oxidative modifications of LDL. | 17050115 |
| Schizophrenia | Deregulated Nutrient Sensing | We conducted a prospective, open study comparing body weight, parameters of insulin resistance in schizophrenia patients treated with either clozapine (n = 10) or amisuLpride ( n = 12). | 17050656 |
| Dyslipidemias | Deregulated Nutrient Sensing | Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia. | 17050799 |
| Dyslipidemias | Deregulated Nutrient Sensing | Characteristics predicting dyslipidemia in drug-naive type 2 diabetes patients. | 17051750 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The necessity of treatment for dyslipidemia increased with the duration of diabetes. | 17051750 |
| Hyperlipidemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Effect of aging and obesity on the expression of dyslipidaemia in children from families with familial combined hyperlipidaemia. | 17054424 |
| Aortic arch structure, Dyslipidemias | Deregulated Nutrient Sensing | Multivariate logistic regression analysis showed that two factors had an independent predictive value of positive DSE: aortic arch atheroma (p = 0.007) and dyslipidemia (p = 0.09). | 17057380 |
| Steatohepatitis, Hepatitis C, Chronic, Necrosis | Deregulated Nutrient Sensing | Hepatic steatosis and insulin resistance are associated with serum imbalance of adiponectin/tumour necrosis factor-alpha in chronic hepatitis C patients. | 17059516 |
| Fatty degeneration | Deregulated Nutrient Sensing | Steatosis and insulin resistance (IR) have a pathogenic role in chronic hepatitis C (HCV). | 17059516 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Moreover, uric acid level was associated with calcium/phosphate metabolism, dyslipidemia, and inflammation. | 17059995 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance and blood pressure circadian variation in an obese hypertensive population. | 17060061 |
| Damage, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance (IR) is related to arterial hypertension and target organ damage. | 17060061 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | Insulin resistance is not associated with nocturnal blood pressure reduction in obese hypertensives. | 17060061 |
| Malignant neoplasm of endometrium, Diabetes Mellitus, Non-Insulin-Dependent, Polycystic Ovary Syndrome, Obesity | Deregulated Nutrient Sensing | Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer. | 17062769 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease. | 17062890 |
| Hyperglycemia | Deregulated Nutrient Sensing | TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. | 17065361 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | While high parity is hypothesized to be associated with insulin resistance and type 2 diabetes, few studies have examined this association in diverse racial samples or geographical areas. | 17065666 |
| Increased insulin level, Cardiovascular Diseases | Deregulated Nutrient Sensing | Trends in hyperinsulinemia among nondiabetic adults in the U.S. Insulin resistance and compensatory hyperinsulinemia have been proposed as increasing risk for a variety of abnormalities and clinical syndromes, including type 2 diabetes and cardiovascular disease. | 17065674 |
| Obesity | Deregulated Nutrient Sensing | Obesity in U.S. adolescents represents the most important risk factor for insulin resistance, independent of sex, age, or race/ethnicity. | 17065679 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of insulin resistance in obese children foreshadows a worrisome trend for the burden of type 2 diabetes in the U.S. | 17065679 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The dysregulation of adipokines is closely associated with the pathogenesis of insulin resistance and type 2 diabetes. | 17065684 |
| Obesity | Deregulated Nutrient Sensing | Retinol-binding protein-4 (RBP4), a new adipokine, was recently reported to provide a link between obesity and insulin resistance. | 17065684 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance. | 17065684 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Low levels are associated with obesity, insulin resistance, and type 2 diabetes. | 17065691 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In the context of diabetes, ROS is suggested to trigger different forms of insulin resistance involving different mechanisms. | 17066297 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Associations between depressive symptoms and insulin resistance: the Hoorn Study. | 17066302 |
| Depression, CTCAE | Deregulated Nutrient Sensing | The association between depression and insulin resistance has been investigated in only a few studies, with contradictory results reported. | 17066302 |
| Bipolar Disorder | Deregulated Nutrient Sensing | The association between depressive symptoms and insulin resistance was similar for men and women. | 17066302 |
| Bipolar Disorder | Deregulated Nutrient Sensing | We found only weak associations between depressive symptoms and insulin resistance, which did not differ among different glucose metabolism subgroups or between men and women. | 17066302 |
| Hashimoto Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Hashimoto's hypothyroidism associated with insulin resistance in type 2 diabetes]. | 17066592 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemic patients show a worse compliance than hypertensive patients, and dyslipidemia worsened global compliance in hypertensive patients. | 17067241 |
| Hypokalemia, Seizures | Deregulated Nutrient Sensing | Hypokalemia (P= 0.001) and insulin resistance (P= 0.025) were more common and seizures (P= 0.01) less frequently reported with the use of TH. | 17067329 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Of 600 men who received a single 10 mg dose of vardenafil, 32% had hypertension, 16% had diabetes and 19% had dyslipidaemia. | 17073835 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | First-dose SEP-2 and SEP-3 success rates were 84% and 66% in men with hypertension (n = 191); 84% and 72% in men with dyslipidaemia (n = 116); and 75% and 58% in men with diabetes (n = 95). | 17073835 |
| Primary malignant neoplasm, Obesity | Deregulated Nutrient Sensing | Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study. | 17075121 |
| Primary malignant neoplasm, Obesity | Deregulated Nutrient Sensing | Although many studies have demonstrated that smoking, alcohol, obesity, and insulin resistance are risk factors for cancer, the role of those factors on cancer survival has been less studied. | 17075121 |
| Diagnosis, Primary malignant neoplasm, Obesity | Deregulated Nutrient Sensing | Prediagnosis risk factors for cancer development (smoking, alcohol consumption, obesity, and insulin resistance) had a statistically significant effect on survival among male cancer patients. | 17075121 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | South Asian adults are known to have very high rates of Coronary heart disease (CHD) and insulin resistance and, even as adolescents, may show higher risk factors for CHD. | 17077065 |
| Pancreatic enzyme, Dyslipidemias, Pancreas | Deregulated Nutrient Sensing | Can pancreatic steatosis explain the finding of pancreatic hyperenzymemia in subjects with dyslipidemia? | 17079938 |
| Pancreatic enzyme, Dyslipidemias, Pancreas, Fatty degeneration | Deregulated Nutrient Sensing | It has been proposed by some investigators that benign pancreatic hyperenzymemia could result from pancreatic steatosis that they believe would have been caused by dyslipidemia; their diagnosis of steatosis was based on the finding of a hyperechogenic pancreas at ultrasound. | 17079938 |
| Pancreatic enzyme, Dyslipidemias | Deregulated Nutrient Sensing | In addition, 6 subjects with benign pancreatic hyperenzymemia but who did not have dyslipidemia or hyperechogenic pancreas and 10 healthy subjects with none of these conditions were also studied as controls. | 17079938 |
| Dyslipidemias, Fatty infiltration | Deregulated Nutrient Sensing | Magnetic resonance imaging showed normal pancreas with no signs of fatty infiltration in all 18 subjects with dyslipidemia, including those with both dyslipidemia and hyperechogenic pancreas at ultrasound. | 17079938 |
| Pancreatic enzyme, Dyslipidemias, Pancreas | Deregulated Nutrient Sensing | The finding of a completely normal pancreas at magnetic resonance imaging does not support the proposed model in which pancreatic hyperenzymemia in subjects with dyslipidemia is attributed to pancreatic steatosis. | 17079938 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Hypertension, CTCAE, Mental disorders | Deregulated Nutrient Sensing | There were significant associations between increased severity of ED and presence of diabetes, hypertension, dyslipidemia, ischemic heart disease, myocardial infarction, and psychological disorders. | 17081221 |
| Hypertension, CTCAE, Diabetic Angiopathies, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The higher risk for lower esRAGE was still significant even after adjusted either with body mass index, hypertension, dyslipidemia and vascular complications, but was confounded by age and diabetes. | 17082489 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Previous research has reported reduced serum 25-hydroxyvitamin D levels in patients with chronic kidney disease (CKD), although the relationship between vitamin D status and insulin resistance (IR) in patients with CKD has not been examined in the general population. | 17082756 |
| Obesity, Abdominal, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In conclusion, the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women. | 17087055 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | The investigation was performed in three groups of subjects with a different prevalence of insulin resistance: 72 non-diabetics with ischemic heart disease, 117 young blood donors and 63 type 2 diabetics on diet therapy only. | 17087600 |
| Abnormal circulating valine concentration, Diabetes Mellitus, Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. | 17091361 |
| Sandawe language | Deregulated Nutrient Sensing | Waist circumference and SAD were positively correlated with leptin and insulin resistance and negatively correlated with adiponectin. | 17093174 |
| Weight decreased | Deregulated Nutrient Sensing | After moderate weight loss, midthigh subcutaneous AT, IAT, low-density lean tissue, leptin, and insulin resistance decreased significantly; no significant changes in adiponectin were observed. | 17093174 |
| Weight decreased, Infiltration | Deregulated Nutrient Sensing | Even in older women, moderate weight loss improves body fat distribution, muscle lipid infiltration, and insulin resistance. | 17093174 |
| Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolism, Diabetes Mellitus | Deregulated Nutrient Sensing | Mitochondrial dysfunction and increased intramyocellular lipid (IMCL) content have both been implicated in the development of insulin resistance and type 2 diabetes mellitus, but the relative contributions of these two factors in the aetiology of diabetes are unknown. | 17093944 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The finding that in vivo mitochondrial function is decreased in type 2 diabetes patients compared with controls whereas IMCL content is similar suggests that low mitochondrial function is more strongly associated with insulin resistance and type 2 diabetes than a high IMCL content per se. | 17093944 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity, hypertension and dyslipidaemia were present in most patients, diabetes in 17.3% of them. | 17096010 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The first 6 months after birth may be the most critical period for growth, in relation to development of glucose intolerance. | 17096117 |
| Fever, CTCAE, Coughing, Dyslipidemias, Anemia, Dyspnea | Deregulated Nutrient Sensing | The patients presented with fever, cough, dyspnea, anemia, and dyslipidemia. | 17097960 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, body mass index (BMI), and non-Caucasian self-identity were directly related to insulin resistance (IR); however, age, CD4 lymphocyte count, and rates of treatment with HAART were not. | 17099311 |
| Hypoadiponectinemia, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Hypoadiponectinemia has been implicated in the development of obesity-related conditions, including dyslipidemia and coronary heart disease (CHD). | 17101706 |
| Coinfection, Lipodystrophy, Hepatitis C | Deregulated Nutrient Sensing | Among HIV-infected patients, hepatitis C virus (HCV) coinfection is associated with increased rates of lipodystrophy and insulin resistance. | 17105512 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | After controlling for duration of protease inhibitor (PI) therapy, race, alanine aminotransferase (ALT) concentration and platelet count, HCV remained an independent predictor of hypercholesterolaemia (RR=0.369; P=0.01) and any dyslipidaemia (RR=0.531; P=0.019). | 17105512 |
| Dyslipidemias | Deregulated Nutrient Sensing | HCV coinfection independently predicted lower rates of dyslipidaemia among HIV-infected patients. | 17105512 |
| Dyslipidemias | Deregulated Nutrient Sensing | In addition, the rate of dyslipidaemias was lower among HCV-monoinfected than HIV/HCV-coinfected patients (29.5% vs 50.5; P=0.002). | 17105512 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The area under the receiver-operating characteristic curve for WHtR was significantly higher than for all other anthropometric parameters with respect to all risk conditions in women and to dyslipidemia and type 2 diabetes in men. | 17105840 |
| Hypertriglyceridemia, Metabolic Syndrome X | Deregulated Nutrient Sensing | Our results suggest that genetic variation at the eNOS locus is associated with features of metabolic syndrome, and might represent a new genetic susceptibility component for insulin resistance, hypertriglyceridemia, and low HDL-cholesterol concentrations. | 17110473 |
| TG gene, CD55 gene, Dyslipidemias, Family history | Deregulated Nutrient Sensing | We compared the obtained serum lipid profile with that of the Lipid Research Clinic (LRC) and calculated the predictive value of FH for detecting those children with dyslipidemia.Overall, for both genders and for age groups, the mean serum triglycerides (TG) and its percentiles were significantly higher, and the mean and percentiles of total, low-density, and high-density cholesterol (TC, LDL-C, and HDL-C respectively) were significantly lower than the LRC values. | 17111289 |
| Dyslipidemias, Family history | Deregulated Nutrient Sensing | The sensitivity, and specificity, positive and negative predictive values for FH in detecting those children with dyslipidemia were 28.4, 70.3. | 17111289 |
| Obesity | Deregulated Nutrient Sensing | Older lean women showed lower levels of ghrelin (p<0.05) than young lean women, with no differences regarding BP, obesity, lipids, adipokines or insulin resistance (IR). | 17113660 |
| Hypertrophy | Deregulated Nutrient Sensing | Its lower increase may be due, in addition to the characteristics of their chest walls, to insulin resistance which may limit the increase in lactic acid during effort, and to the hypertrophy of muscle fibers previously noted, which may be linked to a lower increase in plasma K(+) during physical exercise. | 17114876 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Haemoglobin A1c is not a surrogate for glucose and insulin measures for investigating the early life and childhood determinants of insulin resistance and Type 2 diabetes in healthy children. | 17116188 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Research into early life and childhood determinants of insulin resistance and Type 2 diabetes are complicated by requirements for fasting blood samples and glucose tolerance tests. | 17116188 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Abdominal obesity and insulin resistance in patients with type 2 diabetes in a Swedish community. | 17118860 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To explore the association between abdominal obesity and insulin resistance in patients with type 2 diabetes. | 17118860 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | WC provides a feasible measure for insulin resistance in the vast majority of subjects with type 2 diabetes. | 17118860 |
| Obesity, Nephrolithiasis | Deregulated Nutrient Sensing | Future research should focus on more obese subjects in whom insulin resistance and particular kidney functions should also be examined to further substantiate the role of obesity in low-urine pH-associated conditions, for example, nephrolithiasis. | 17119545 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These findings suggest that leptin resistance exists in patients with NAFLD and leptin resistance is positively correlated with NAFLD, the same as in insulin resistance. | 17125610 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Relationships between the functional PPARalpha Leu162Val polymorphism and obesity, type 2 diabetes, dyslipidaemia, and related quantitative traits in studies of 5799 middle-aged white people. | 17129741 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The common Leu162Val polymorphism in the gene encoding PPARalpha has inconsistently shown association with quantitative traits related to obesity, type 2 diabetes, and dyslipidaemia. | 17129741 |
| Dyslipidemias | Deregulated Nutrient Sensing | In addition, the Leu162Val polymorphism was not associated with WHO-defined obesity or dyslipidaemia in case-control settings involving 961 obese and 2563 lean subjects and 1399 dyslipidaemic and 4399 normolipidaemic subjects, respectively. | 17129741 |
| Presenile dementia, Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance is a potentially modifiable midlife risk factor for cognitive decline and dementia. | 17130206 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance, inflammatory biomarkers, and adipokines in patients with chronic kidney disease: effects of angiotensin II blockade. | 17130263 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Patients with chronic kidney disease (CKD) present a high prevalence of insulin resistance (IR). | 17130263 |
| Dyslipidemias, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Although substantial evidence suggests that treatment of dyslipidemia with statins reduces mortality and morbidity that are associated with cardiovascular disease, only a few studies have examined the efficacy of statins on inflammatory and fibrinolytic status in patients with chronic kidney disease (CKD). | 17130267 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | The long-term impact of dietary carbohydrate type, in particular sucrose, on insulin resistance and the development of diabetes and atherosclerosis is not established. | 17130505 |
| Lipodystrophy | Deregulated Nutrient Sensing | Gastric bypass for insulin resistance due to lipodystrophy. | 17132423 |
| Lipodystrophy | Deregulated Nutrient Sensing | We report a 41-year-old woman with severe insulin resistance due to partial lipodystrophy, who was successfully treated with gastric bypass surgery. | 17132423 |
| Atherosclerosis | Deregulated Nutrient Sensing | Carbohydrate nutrition, glycaemic load, and plasma lipids: the Insulin Resistance Atherosclerosis Study. | 17132647 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertrophy, Hypertension, CTCAE | Deregulated Nutrient Sensing | Reduced eGFR was associated with increased prevalence of established cardiovascular risk factors [cardiovascular disease, diabetes, hypertension, left ventricular (LV) hypertrophy, and dyslipidaemia] and higher levels of inflammatory markers [interleukin 6 (IL-6), C-reactive protein], endothelial markers [von Willebrand factor (vWF) and tissue plasminogen activator], activated coagulation markers (fibrin D-dimer), and blood viscosity. | 17132648 |
| Kidney Failure, Chronic, diabetic | Deregulated Nutrient Sensing | Prevalence, severity and predictors of HOMA-estimated insulin resistance in diabetic and nondiabetic patients with end-stage renal disease. | 17136689 |
| Kidney Failure, Chronic, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Prevalence of insulin resistance (IR) is increased in type 2 diabetes and in end-stage renal disease (ESRD). | 17136689 |
| Hyperglycemia, Postprandial, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | This case suggests that postprandial hyperglycemia and insulin resistance might be one of the possible underlying mechanisms of paroxysmal atrial fibrillation. | 17136822 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The utility of non-HDL in managing dyslipidemia of stage 5 chronic kidney disease. | 17140163 |
| Hypertriglyceridemia, Dyslipidemias, Coronary heart disease, Kidney Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The Kidney Disease Outcomes Quality Initiative (K/DOQI) treatment guidelines for managing dyslipidemia in patients with chronic kidney disease (CKD) designate CKD as a high-risk category for coronary heart disease and, in Stage 5 CKD patients, recommend maintaining low-density lipoprotein (LDL) < 100 mg/dl and, for patients with hypertriglyceridemia (> or = 200 mg/ dl), non-high-density lipoprotein (non-HDL) < 130 mg/dl, the latter to achieve very low-density lipoprotein (VLDL) < 30 mg/dl. | 17140163 |
| Chronic Kidney Diseases, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | In Stage 5 CKD patients at hemodialysis inception, dyslipidemia is highly prevalent with predominance of the atherogenic triad (hypertriglyceridemia, elevated VLDL and reduced HDL). | 17140163 |
| Steatohepatitis | Deregulated Nutrient Sensing | Intake of nutrients strongly affects insulin resistance, carbohydrate and lipid metabolism, and hepatic steatosis. | 17140767 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with at least two cardiovascular risk factors in addition to dyslipidemia (primary prevention) or with past cardiovascular disease (secondary prevention) were recruited by general practitioners (GPs). | 17141490 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | We measured the carotid intima-media thickness (IMT), LDL particle size, and insulin resistance in 136 nondiabetic subjects. | 17142132 |
| Atherosclerosis | Deregulated Nutrient Sensing | We conclude that LDL particle size was associated with insulin resistance, but age, triglyceride, and HDL-C contributed independently to the variability in LDL particle size, and LDL particle size was not a predictor of preclinical atherosclerosis in nondiabetic Koreans. | 17142132 |
| Weight decreased, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | In the 24 obese children with substantial weight loss, intima-media thickness, blood pressure, triglycerides, insulin, and insulin resistance index decreased significantly, whereas high-density lipoprotein cholesterol increased significantly. | 17142516 |
| Weight decreased | Deregulated Nutrient Sensing | In the 32 obese children without substantial weight loss, there were no significant changes apart from an increase of insulin and insulin resistance index. | 17142516 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Among the offspring, lower birthweight was associated with an increased risk of glucose intolerance (impaired glucose tolerance, impaired fasting glucose or type 2 diabetes) and higher cholesterol and triacylglycerol concentrations (p < 0.05 for all adjusted for sex and age). | 17143606 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alternate-day dosing of atorvastatin: effects in treating type 2 diabetic patients with dyslipidaemia. | 17143784 |
| Atherosclerosis | Deregulated Nutrient Sensing | Association of insulin resistance with distance to wealthy areas: the multi-ethnic study of atherosclerosis. | 17148499 |
| Vascular calcification | Deregulated Nutrient Sensing | Leptin is associated with adiposity and insulin resistance and may play a direct role in vascular calcification. | 17148566 |
| Hyperglycemia, Dyslipidemias, Inflammation | Deregulated Nutrient Sensing | The variability of hyperglycemia, dyslipidemia, and inflammation with age progression was also studied for comparison. | 17151300 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Obesity | Deregulated Nutrient Sensing | Hyperglycemia showed no variability with age whereas dyslipidemia correlated positively with age progression, as well as obesity, low physical activity, and family history of heart disease or diabetes. | 17151300 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Switch to 1.5 grams MMF monotherapy for CNI-related toxicity in liver transplantation is safe and improves renal function, dyslipidemia, and hypertension. | 17154392 |
| Renal Insufficiency, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | We attempted the complete weaning off CNI in 42 individuals presenting chronic renal dysfunction and/or dyslipidemia and/or arterial hypertension and simultaneously introduced 1.5 gm/day MMF. | 17154392 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Strain gradient significantly decreased in parallel with the presence of dyslipidemia and/or type 2 diabetes. | 17158335 |
| Dyslipidemias, Cardiomyopathies | Deregulated Nutrient Sensing | The groups were similar in respect to race, creatinine, cholesterol, and history of dyslipidemia and cardiomyopathy. | 17161055 |
| Diabetes Mellitus, diabetic, Obesity, Hypertension, CTCAE, Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies. | 17161225 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This suggests that glucose intolerance (type 2 diabetes mellitus) is an important factor that disturbs Cr metabolism. | 17161231 |
| Coronary Artery Disease, Heart failure | Deregulated Nutrient Sensing | Patients with coronary artery disease and heart failure exhibit myocardial insulin resistance, and this is greater in those with T2DM. | 17161251 |
| Inflammation, physiopathological, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance, inflammation, and blood pressure determine vascular dysfunction in CKD. | 17162147 |
| Inflammation, Dyslipidemias, Systolic hypertension, physiopathological, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance, inflammation, systolic hypertension, and increased pulse pressure, but not dyslipidemia, were associated with vascular dysfunction and may be targets for future interventional strategies to reduce CVD risk in patients with CKD. | 17162147 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokers. | 17162243 |
| Increased insulin level, Colorectal Carcinoma, Hyperglycemia | Deregulated Nutrient Sensing | Data from this prospective study of male smokers provide limited support for hyperinsulinemia, hyperglycemia, and/or insulin resistance as CRC risk factors. | 17162243 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Insulin resistance appears to be a weak determinant of DM in Turkish women while abdominal obesity is the main determinant. | 17162275 |
| Weight decreased | Deregulated Nutrient Sensing | Reductions in circulating RBP-4 may contribute to improved insulin resistance in morbidly obese subjects after weight loss. | 17164313 |
| Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | The effect of fluvastatin on cICAM-1 as a biomarker of endothelial dysfunction in patients with dyslipidemia. | 17164750 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | In type 2 diabetic patients, tesaglitazar dose-dependently reduced FPG levels at doses > or = 0.5 mg. Other markers of glycemic control, atherogenic dyslipidemia, and measures associated with insulin resistance were improved at doses > or = 0.5 mg or > or = 1.0 mg. Study limitations included that the majority of patients were white, patients had good glycemic control at baseline, and the increased number of early withdrawals in the tesaglitazar 2.0 mg and 3.0 mg doses limits conclusions about the efficacy of these doses. | 17166340 |
| Hyperglycemia | Deregulated Nutrient Sensing | [Study of relationship between stress hyperglycemia and insulin-resistance related factors]. | 17166359 |
| Hyperglycemia | Deregulated Nutrient Sensing | To observe related factors in the stress hyperglycemia (SHG) of critical illness and to investigate possible pathogenesis of insulin-resistance (IR). | 17166359 |
| IGA Glomerulonephritis | Deregulated Nutrient Sensing | Insulin resistance and the progression of IgA glomerulonephritis. | 17166857 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | Insulin resistance was associated with obesity but not with PCOS. | 17166864 |
| Tumor necrosis | Deregulated Nutrient Sensing | Tumor necrosis factor-alpha (TNF-alpha) has an increased expression in the adipose tissue of obese subjects and is involved in insulin resistance. | 17167711 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Resistin (RSN) is an adipocytokine involved in insulin resistance, obesity and atherosclerosis. | 17173885 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our data suggest that noncoding SNPs may increase diabetes susceptibility in Caucasians and may contribute to insulin resistance and reduced insulin secretion. | 17174134 |
| Congestive heart failure | Deregulated Nutrient Sensing | Insulin resistance is present in the setting of congestive heart failure. | 17174230 |
| Obesity | Deregulated Nutrient Sensing | Little is known about obesity and insulin resistance in college students. | 17175904 |
| Obesity | Deregulated Nutrient Sensing | Leptin is a hormone secreted by fat cells and has been shown to strongly correlate with both obesity and insulin resistance in children and adults. | 17175904 |
| Obesity | Deregulated Nutrient Sensing | Leptin was associated with fasting insulin (beta+/-SE = 0.30+/-0.06, p < .001) and insulin resistance (beta+/-SE = 0.41+/-0.20, p < .001) independent of total fat, gender, and age, suggesting other mechanisms of leptin and insulin regulation besides obesity. | 17175904 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly. | 17178123 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Amelioration of insulin resistance could improve both glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus. | 17178700 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | The age-adjusted prevalences of hypertension, dyslipidaemia and overweight in males were significantly higher (p < 0.001) than in females. | 17180353 |
| Bowens Disease | Deregulated Nutrient Sensing | Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. | 17180656 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | SIRT1 regulates cell survival via deacetylation of p53 and forkhead transcription factors, and overexpression of SIRT1 is reported to be essential for cell growth and survival in some kinds of cancer. | 17180656 |
| Skin carcinoma | Deregulated Nutrient Sensing | Overexpression of SIRT1 is frequently observed in all kinds of non-melanoma skin cancers included in this study. | 17180656 |
| Skin Carcinogenesis | Deregulated Nutrient Sensing | In addition, no obvious difference between AK and SCC was observed in the expression of SIRT1, suggesting that overexpression of SIRT1 may have some relevance to the early stage of skin carcinogenesis. | 17180656 |
| Skin carcinoma | Deregulated Nutrient Sensing | We suppose that SIRT1 could be one of the critical targets for future therapy with the aim of inhibiting cell proliferation and promoting apoptosis in non-melanoma skin cancers. | 17180656 |
| Increased insulin level, Primary malignant neoplasm, Inflammation, Depressed mood | Deregulated Nutrient Sensing | These lifestyle patterns may increase cancer risk by several mechanisms including increased estrogens and testosterone, hyperinsulinemia and insulin resistance, increased inflammation, and depressed immune function. | 17182820 |
| ETV3 wt Allele, Congestive heart failure | Deregulated Nutrient Sensing | MetS was associated with about a twofold increased likelihood of self-reported CHF and it may serve as a surrogate indicator for the association between insulin resistance and CHF. | 17183018 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | The findings suggest that in this case the CD36 deficiency type 1 was the pathogenic mechanism of acute coronary syndrome relative to insulin resistance and modification of the lipid profile. | 17186996 |
| Congestive heart failure | Deregulated Nutrient Sensing | Indices of insulin resistance were higher amongst CHF patients compared with controls, with no ethnic variation. | 17187880 |
| Congestive heart failure | Deregulated Nutrient Sensing | On multivariate regression analysis of patients and healthy controls, CHF was independently associated with smoking habit, adiponectin and insulin resistance (all P<0.01). | 17187880 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Particular attention is given to dyslipidemia, blood pressure, diabetes mellitus, and tobacco cessation. | 17189584 |
| Dyslipidemias, Simultaneous | Deregulated Nutrient Sensing | The main aim was to obtain data on the therapeutic approaches to patients observed in cardiology hospital outpatient clinics with high blood pressure and/or dyslipidemia as well as other concomitant diseases, in order to plan future wider-ranging studies and to analyze the main risk factors of cardiovascular conditions in this population. | 17190239 |
| Dyslipidemias, Diabetes Mellitus, Pathology, Coronary heart disease | Deregulated Nutrient Sensing | Of these patients, 87.7% had high blood pressure, 75.8% had dyslipidemia and 63.5 % had both pathologies; the prevalence of diabetes was high and that of coronary disease was very high. | 17190239 |
| Depressed mood | Deregulated Nutrient Sensing | The herein presented longitudinal data do not exclude the HPA system as a major contributor to insulin resistance in depressed patients, but underscore the assumption of additional factors. | 17194262 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study. | 17194277 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | We suggest that patients taking SSRIs be carefully monitored for obesity and dyslipidemia. | 17194277 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques: evidence for a corrective effect of statins. | 17196206 |
| Dyslipidemias | Deregulated Nutrient Sensing | In patients with untreated dyslipidemia (ApoB/ApoA1 ratio >0.7) (D+) (n=44), TF antigen (TF) tended to be higher than in those without dyslipidemia (D-) (n=16). | 17196206 |
| Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | Among analyzed clinical risk factors and biological parameters, including CRP, dyslipidemia was the only independent predictor for low plaque TFPI and high TF/TFPI ratio. | 17196206 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results indicate that dyslipidemia is associated with a shift of the TF/TFPI balance and of TF activity toward higher plaque thrombotic potential. | 17196206 |
| Cardiovascular Diseases, Microalbuminuria, Dyslipidemias, Diabetes Mellitus, diabetic, Obesity, Renal Insufficiency, Hypertension, CTCAE | Deregulated Nutrient Sensing | Impaired renal function was 38.2% and 49.1% respectively in the subjects with diabetes and IGR; (3) The prevalence of microalbuminuria was significantly higher in the diabetic patients with hypertension, central obesity, dyslipidemia, history of cardiovascular disease or selinity. | 17198559 |
| Dyslipidemias | Deregulated Nutrient Sensing | These data suggest that the dyslipidaemia previously attributed to smoking occurs primarily in those smokers who are also insulin resistant. | 17199720 |
| Obesity | Deregulated Nutrient Sensing | Intramuscular lipid content increases with aging and obesity and is directly related to impaired glucose tolerance and insulin resistance. | 17200170 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A high prevalence of coronary risk factors was present: systemic hypertension (64%), diabetes mellitus (40%), dyslipidemia (35%), smoking (33%) and previous CAD (32%). | 17203791 |
| Glucose Intolerance (disease), Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | These abnormalities in LV function were more common not only in subjects with diabetes, but also in patients with prediabetic condition, impaired glucose intolerance. | 17204040 |
| TG gene, CD55 gene, Dyslipidemias, Hypertriglyceridemia | Deregulated Nutrient Sensing | Urban men had a significantly higher prevalence of dyslipidemia (TC > or =240 and LDL-C > or = 60 mg/dl) than rural men (25.9 vs. .3.7 per cent for TC and 16.7 vs. 3.7 percent for LDL-C, p < 0.001) while the prevalence of hypertriglyceridemia (> or =200 mg/dl) and low HDL-C (< 40 mg/dl) was significantly higher in rural women (18.2 vs. 7.9 percent for TG and 15.0 vs. 3.8 per cent of HDL-C, p < 0.001). | 17205863 |
| Dyslipidemias | Deregulated Nutrient Sensing | Migration to urban centers and adopting an urban lifestyle is likely related to the rising lipid level and prevalence of dyslipidemia. | 17205863 |
| Obesity | Deregulated Nutrient Sensing | Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile. | 17211557 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a major factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and is related to the fatty acid profile of the plasma membranes. | 17211560 |
| Congenital Abnormality | Deregulated Nutrient Sensing | This situation may cause, at least in part, RBC-WBC function abnormalities and insulin resistance because of inconvenient membrane fluidity. | 17211560 |
| Dyslipidemias, Diabetes Mellitus, Congestive heart failure, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Preexisting medical conditions (hypertension, dyslipidemia, diabetes mellitus, congestive heart failure, chronic renal disease) also significantly affected the risk for CVEs. | 17213003 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | As early detection of subjects with risk of diabetes is important, it is crucial to understand the relationship between different levels of FPG, insulin resistance (IR) and insulin secretion. | 17213521 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The results of an age- and sex-adjusted logistic regression analysis indicated that BMI obesity was associated with dyslipidemia (p=0.04), WC obesity was associated with dyslipidemia (p=0.07), and 'obesity' was associated with diabetes (p=0.06) and dyslipidemia (p=0.01). | 17213689 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to investigate the association between insulin resistance and physical fitness, leptin concentration, body composition and family history for diabetes in non-selected young children. | 17215165 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The influence of family history for diabetes on insulin resistance is shown as a trend at this age. | 17215165 |
| TG gene | Deregulated Nutrient Sensing | The apo A-I/HDL cholesterol ratio significantly increased by 3% in men at 2:30 p.m. and by 5% both in men and women at 5:00 p.m. Postprandial serum TG were higher and HDL cholesterol and apo A-I were lower in subjects of both genders with insulin resistance (high HOMA(IR)) than in those with low HOMA(IR). | 17217150 |
| Dental Plaque | Deregulated Nutrient Sensing | Compared to subjects identified by NCEP definition, subjects identified in excess by IDF (3.1-11.7%) showed less insulin resistance and lower IMT and plaque extent indistinguishable from MetS-free subjects. | 17217376 |
| ETV3 wt Allele, Atherosclerosis | Deregulated Nutrient Sensing | Our data suggest that the IDF definition includes subjects as MetS sufferers above these detected by NCEP or WHO, who exhibit considerably less insulin resistance and carotid atherosclerosis blurring the distinction between health and disease. | 17217376 |
| Dyslipidemias, Ischemic stroke, Tacca leontopetaloides | Deregulated Nutrient Sensing | Identification of dyslipidemia and treatment with lipid-lowering agents are established targets for quality performance during hospitalization for ischemic stroke and transient ischemic attack (TIA). | 17219502 |
| Tacca leontopetaloides, Ischemic stroke, Dyslipidemias | Deregulated Nutrient Sensing | Measurement of LDL-C was most strongly and independently associated with diagnosis of ischemic stroke (vs. TIA, P = .02) and history of dyslipidemia (P = .05). | 17219502 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Independent predictors for being prescribed lipid-lowering agents at discharge were diagnosis of ischemic stroke (P = .0009), LDL-C testing (P = .0002), high risk of future coronary events according to national guidelines (P = .02), and history of dyslipidemia (P< .0001). | 17219502 |
| Inflammation, Hypertension, CTCAE | Deregulated Nutrient Sensing | Oxidative stress (OS), inflammation and insulin resistance are among the mechanisms that have been recently implicated in pathogenesis of essential hypertension (EH). | 17220028 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Evaluation of glucose intolerance in adolescents relative to adults with type 2 diabetes mellitus. | 17220060 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Obesity and glucose intolerance are also a problem in developing countries. | 17220060 |
| Dyslipidemias | Deregulated Nutrient Sensing | Effect of atorvastatin on type 2 diabetic dyslipidemia. | 17220473 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is considered to play an important role in the development of cardiovascular disease, which limits long-term renal transplant survival. | 17220787 |
| Obesity | Deregulated Nutrient Sensing | Our results indicate that obesity, distribution of obesity, and prednisolone treatment are the predominant determinants of insulin resistance long term after transplantation. | 17220787 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance after renal transplantation could be managed favorably by weight and prednisolone dose reduction, which may reduce cardiovascular disease. | 17220787 |
| Vascular System Injuries | Deregulated Nutrient Sensing | Key role of insulin resistance in vascular injury among hemodialysis patients. | 17224326 |
| Hypertensive (finding), diabetic | Deregulated Nutrient Sensing | Insulin resistance prevails not only among diabetic patients but also among hypertensive and obese patients. | 17224326 |
| HD Term Type, Cardiovascular Diseases | Deregulated Nutrient Sensing | The relationship between insulin resistance and cardiovascular diseases was investigated in hemodialysis (HD) patients. | 17224326 |
| HD Term Type, Vascular System Injuries | Deregulated Nutrient Sensing | The present results provide evidence that angiotensin inhibition improves insulin resistance, possibly preventing vascular injury in HD patients. | 17224326 |
| HD Term Type | Deregulated Nutrient Sensing | Finally, our findings suggest that insulin resistance is prognostic of cardiovascular events in HD patients. | 17224326 |
| Obesity | Deregulated Nutrient Sensing | The lack of association between inflammatory markers and HOMA-IR suggests that obesity may precede the elevation of these markers in the evolution of insulin resistance in youth. | 17224334 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | glucose infusion, respectively, to further elucidate the mechanisms behind the glucose intolerance in patients with type 2 diabetes. | 17225124 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We suggest that this phenomenon contributes both to the glucose intolerance and to the reduced incretin effect observed in patients with type 2 diabetes. | 17225124 |
| Obesity | Deregulated Nutrient Sensing | Reduced serum levels of adiponectin in obesity and insulin resistance seem paradoxical, since adipose tissue is the only source of adiponectin, and reports on that subject are contradictory. | 17226110 |
| Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Use of the IDF definition, which requires central obesity, is associated with greater insulin resistance but similar levels of other cardiovascular disease risk factors than the use of the AHA/NHLBI definition, which does not require central obesity. | 17228055 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The IDF definition may be more appropriate for the identification of those with insulin resistance and increased risk of type 2 diabetes. | 17228055 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The incidence of hypertension, glucose intolerance, insulin resistance and dyslipidemia was lower compared with obese women. | 17228087 |
| ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | Although they are not sufficient to support the hypothesis of differences in the underlying pathophysiological processes between these groups, our results illustrate the difficulty of using a single unifying definition of MetS, and suggest that different benefits may be obtained from treatments targeting obesity, blood pressure or insulin resistance. | 17229178 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia [low high-density lipoprotein (HDL)-cholesterol] and impaired fasting glucose were more prevalent among the Brazilians, and increased blood pressure and abdominal obesity (in men) among the Italians. | 17229178 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Thiazolidinediones (TZD) may improve insulin resistance in patients with diabetes and HIV. | 17235334 |
| Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Risk factors for coronary artery disease (hypertension, diabetes mellitus, dyslipidemia, smoking, and obesity) were obtained from medical records to identify possible simultaneous risk factors for coronary artery disease. | 17236987 |
| Increased insulin level, Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance in liver cirrhosis was higher than the other type 2 DM, and impaired hepatic insulin degradation might be an important mechanism of hyperinsulinemia in liver cirrhosis. | 17237630 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. | 17237906 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased insulin resistance and dyslipidemia were known risk factors in patients with active RA, however, the regulation of these metabolic parameters by TNF-alpha is poorly understood. | 17237906 |
| Hypertensive (finding), diabetic | Deregulated Nutrient Sensing | In conclusion, Telmisartan improved insulin resistance with increased serum leptin level in hypertensive and type 2 diabetic patients. | 17240472 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Three definitions were applied: National Cholesterol Education Program (NCEP), European Group for the Study of Insulin Resistance (EGIR) and International Diabetes Federation (IDF) criteria. | 17241181 |
| Prediabetes syndrome, Prehypertension | Deregulated Nutrient Sensing | Surrogate markers of insulin resistance in assessing individuals with new categories "prehypertension" and "prediabetes". | 17243912 |
| Prediabetes syndrome, Prehypertension | Deregulated Nutrient Sensing | There are few data on the impact of insulin resistance on the recently defined categories of prehypertension (PHT) and prediabetes (PDM). | 17243912 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In postmenopausal women, endogenous estradiol (E2) and free testosterone (T) have been positively associated with glucose intolerance and type 2 diabetes. | 17244779 |
| Dyslipidemias | Deregulated Nutrient Sensing | There is a primary focus in cholesterol management on the elevated low-density lipoprotein cholesterol (LDL-C) component of dyslipidemia and a secondary focus on the other components of dyslipidemia, such as low high-density lipoprotein cholesterol (HDL-C), high triglycerides (TGs), and high non-HDL-C. | 17249907 |
| Dyslipidemias | Deregulated Nutrient Sensing | Combination therapy to treat dyslipidemia has become common in many patients; however, it can also increase the risk of serious adverse effects. | 17253923 |
| Glucose Intolerance (disease), Structure of beta Cell of islet | Deregulated Nutrient Sensing | Pancreatic B-cell function decreases as glucose intolerance develops. | 17257277 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A 12-month randomized trial was conducted in 72 patients with type 2 diabetes, HbA1c>or=8%, blood pressure (BP)>130/80 mmHg and dyslipidemia. | 17258926 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | Metabolic syndrome increases the risk for type 2 diabetes and cardiovascular disease (CVD) and may be associated with insulin resistance. | 17259468 |
| Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | Metabolic syndrome increased risk for diabetes regardless of insulin resistance. | 17259468 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Metabolic syndrome by ATP III criteria may require insulin resistance to increase risk for CVD. | 17259468 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Insulin resistance and impaired beta-cell function are key elements in the pathogenesis of type 2 diabetes. | 17259491 |
| Inflammation, Kidney Failure, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Because renal failure per se is associated with both increased levels of circulating peptides and marked insulin resistance, even in the absence of diabetes mellitus, we hypothesized that visfatin could be a factor linking inflammation, kidney disease, and insulin resistance in this patient group. | 17261426 |
| Diabetes Mellitus, Non-Insulin-Dependent, Prostate Cancer Outcomes Study, Lipoatrophic Diabetes Mellitus, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | We examined the relationship between insulin resistance and vascular function in three insulin-resistant states (type 2 diabetes, non-HIV lipodystrophic diabetes, and nondiabetic polycystic ovary syndrome [PCOS]) and in healthy control subjects. | 17261751 |
| physiopathological | Deregulated Nutrient Sensing | Insulin resistance, free fatty acids, adiponectin, or C-reactive protein did not associate with vascular dysfunction. | 17261751 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Among these different types of patients with insulin resistance, we found abnormal endothelium-dependent vasodilation only in the patients with type 2 diabetes. | 17261751 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The human acyl-CoA-binding protein (ACBP) is a potential candidate gene of type 2 diabetes (T2D), since it plays a central role in determining the intracellular concentration of activated fatty acids which contribute to insulin resistance. | 17262885 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustment for these factors, adiponectin was significantly inversely associated with insulin resistance, triglyceride, C-reactive protein (but not interleukin 6), tissue plasminogen activator and alanine aminotransferase and positively associated with high-density lipoprotein cholesterol (HDL-cholesterol) and Factor VIII, factors associated with diabetes. | 17264850 |
| Inflammation, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and erythrocyte sedimentation rate (ESR, a non-specific marker of inflammation) are known risk factors for cardiovascular disease. | 17264953 |
| Obesity | Deregulated Nutrient Sensing | Although obesity is associated with increased ESR, it is unclear whether insulin resistance is associated with ESR in humans. | 17264953 |
| Obesity | Deregulated Nutrient Sensing | In conclusion, ESR is independently associated with either insulin resistance or obesity in a sex-specific manner. | 17264953 |
| Tumor necrosis, Cardiac dysfunction, Dilated Cardiomyopathy Pathway | Deregulated Nutrient Sensing | Patients with dilated cardiomyopathy possess insulin resistance independently of cardiac dysfunction or serum tumor necrosis factor-alpha. | 17268122 |
| Doctor of Chiropractic, Dilated Cardiomyopathy Pathway, Congestive heart failure | Deregulated Nutrient Sensing | It has recently been reported that insulin resistance is prevalent in patients with dilated cardiomyopathy (DCM); however, it remains unclear whether insulin resistance is directly induced by DCM or if it is caused by congestive heart failure associated with DCM. | 17268122 |
| Tumor necrosis | Deregulated Nutrient Sensing | We also measured the level of serum tumor necrosis factor (TNF)-alpha as a possible causative factor for inducing insulin resistance. | 17268122 |
| Doctor of Chiropractic, Cardiac dysfunction | Deregulated Nutrient Sensing | In conclusion, patients with DCM possess insulin resistance independently of the severity of cardiac dysfunction or serum TNF-alpha, suggesting that insulin resistance in patients with DCM may be closely associated with the pathogenic condition of DCM itself. | 17268122 |
| Obesity | Deregulated Nutrient Sensing | Patients with insulin resistance and obesity, who commonly have low HDL, may therefore benefit from addition of herring to the diet. | 17268414 |
| Hypertensive disease, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In spite of an overall similar prevalence of smoking, and a lower incidence of dyslipidemia and HTN, moderate CKD patients had a higher prevalence of Whitehall criteria abnormal ECG findings compared with the patients with DM. | 17269521 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. | 17272748 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Because mitochondria play pivotal roles in both insulin secretion from the pancreatic beta cells and insulin resistance of skeletal muscles, we performed a large-scale association study to identify mitochondrial haplogroups that may confer resistance against or susceptibility to type 2 diabetes mellitus (T2DM). | 17273962 |
| Lichen Planus, Demographics Domain, Diabetes Mellitus, diabetic | Deregulated Nutrient Sensing | To establish the prevalence of diabetes mellitus (DM) and insulin resistance in patients with lichen planus (LP), and to examine whether diabetic status showed any relation with the type of LP. | 17275122 |
| Increased insulin level | Deregulated Nutrient Sensing | This fact must be considered for the diagnosis of hyperinsulinism and insulin resistance in children. | 17277855 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Insulin resistance is inversely related to prostate cancer: a prospective study in Northern Sweden. | 17278097 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Factors related to insulin resistance have been implicated in prostate cancer development, however, few analytical studies support such an association. | 17278097 |
| Prostate carcinoma, Neoplasms | Deregulated Nutrient Sensing | Our data suggest that androgens, which are inversely associated with insulin resistance, are important in the early prostate cancer development, whereas insulin resistance related factors may be important for tumour progression. | 17278097 |
| Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | The frequencies of other then hyperglycaemia risk factors were: arterial hypertension - 67%, obesity and overweight respectively 38% and 26%, smoking - 32%, dyslipidemia - 28%. | 17278782 |
| Hyperleucinemia, Hypertensive (finding) | Deregulated Nutrient Sensing | We investigated the effect of a slow-release alpha1-receptor blocker, bunazosin hydrochloride, on leptin levels and insulin resistance in obese hypertensive patients with hyperleptinemia. | 17283868 |
| Hyperleucinemia, Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | In conclusion, bunazosin hydrochloride reduced the plasma leptin level and improved insulin resistance in hypertensive patients with obesity and hyperleptinemia. | 17283868 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low birth weight (LBW), a surrogate marker of an adverse fetal milieu, is linked to muscle insulin resistance, impaired insulin-stimulated glycolysis, and future risk of type 2 diabetes. | 17284623 |
| Overweight | Deregulated Nutrient Sensing | Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance. | 17285123 |
| diabetic | Deregulated Nutrient Sensing | (2) The frequency of C allele is significantly lower in type 2 diabetic patients with insulin resistance compare with those without insulin resistance (P is 0.0121). | 17285539 |
| Hyperglycemia | Deregulated Nutrient Sensing | In contrast to other diseases occurring in the intensive care unit, hyperglycemia or insulin resistance plays no significant role. | 17286217 |
| Fetal Growth Retardation | Deregulated Nutrient Sensing | Insulin resistance has been linked to intrauterine growth retardation (IUGR); adiponectin is a protein with insulin-sensitizing properties. | 17287418 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Some authors suggest that increased serum resistin levels are associated with obesity, visceral fat, insulin resistance, type 2 diabetes and inflammation, while others failed to observe such correlations. | 17287419 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. | 17287471 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. | 17287471 |
| Hyperhomocysteinemia | Deregulated Nutrient Sensing | Furthermore, multiple regression analysis showed that hyperhomocysteinemia was closely related to insulin resistance and visceral adiposity. | 17291621 |
| Hyperhomocysteinemia, IAPP gene | Deregulated Nutrient Sensing | Our results indicate that the presence of hyperhomocysteinemia in our population of Japanese patients with type 2 diabetes-associated insulin resistance was associated with increased visceral but not subcutaneous adiposity. | 17291621 |
| Cardiac complication, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance constitutes a pathophysiologic link between obesity, atherosclerosis, and/or cardiovascular complications. | 17292720 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The FABP2 Ala54Thr polymorphism has been associated with insulin resistance and diabetes in several populations. | 17292994 |
| Restenosis | Deregulated Nutrient Sensing | Hemoglobin A1C, insulin, and insulin resistance at the time of the PCI are not associated with restenosis. | 17293264 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes. | 17299074 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Understanding the relationship of these adipokines to insulin resistance may foster the development of new treatments for diabetes. | 17299074 |
| Lipodystrophy, Pancreatitis, Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | lipodystrophy and early childhood diabetes with extreme insulin resistance and hypertriglyceridemia leading to recurrent pancreatitis, was assessed at an academic medical center. | 17299075 |
| Obesity | Deregulated Nutrient Sensing | These lipid changes were associated with insulin resistance, a pathogonomic characteristic of acquired obesity in these young adult twins. | 17299598 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Our results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance. | 17299598 |
| Overweight | Deregulated Nutrient Sensing | Insulin resistance and degree of overweight were associated with the MS. | 17301109 |
| Increased insulin level, Carcinogenesis, Malignant neoplasm of endometrium, Diabetes Mellitus | Deregulated Nutrient Sensing | Although there is accumulating evidence that hyperinsulinemia in the context of insulin resistance is associated with carcinogenesis, only one prospective study of endometrial cancer incidence, in relation to diabetes, addressed this issue and showed no significant positive association. | 17301260 |
| Overweight | Deregulated Nutrient Sensing | Serum adiponectin and leptin levels and insulin resistance in children born large for gestational age are affected by the degree of overweight. | 17302868 |
| Obesity | Deregulated Nutrient Sensing | The adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features. | 17302872 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. | 17303077 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Rosiglitazone and carotid IMT progression rate in a mixed cohort of patients with type 2 diabetes and the insulin resistance syndrome: main results from the Rosiglitazone Atherosclerosis Study. | 17305652 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is associated with progression of atherosclerosis. | 17305652 |
| Diabetes Mellitus, Non-Insulin-Dependent, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | We assessed the effect of 12 months of treatment with rosiglitazone (RSG) on the progression of carotid intima-media thickness (IMT) in people with type 2 diabetes mellitus (T2DM) or the insulin resistance syndrome (IRS). | 17305652 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Physical inactivity, low education, dyslipidemia, hypertension and diabetes were associated with CHD. | 17306273 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | An elevated PLTP activity in HD patients may be considered as a further aspect of uremic dyslipidemia in HD patients. | 17308375 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, GYPB gene, Hyperuricemia, "Sjogrens Syndrome | Deregulated Nutrient Sensing | To analyze the prevalence and clinical significance of associated metabolic alterations [dyslipidemia, diabetes mellitus (DM), and hyperuricemia] in a large series of unselected patients with primary Sjogren's syndrome (SS). | 17309127 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | In comparison with controls, patients with primary SS showed a higher frequency of dyslipidemia (47% vs 33%; p = 0.002), DM (28% vs 18%; p = 0.006), and hyperuricemia (9% vs 4%; p = 0.007). | 17309127 |
| Dyslipidemias, Demographics Domain, Hyperuricemia | Deregulated Nutrient Sensing | Patients with primary SS showed a higher prevalence of associated dyslipidemia, DM, and hyperuricemia in comparison with an age and sex-matched control group. | 17309127 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. | 17309383 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study was done to determine whether the supplement of Agaricus blazei Murill extract improves insulin resistance in type 2 diabetes. | 17309383 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Supplement of ABM extract improves insulin resistance among subjects with type 2 diabetes. | 17309383 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Management of dyslipidaemia in patients with type 2 diabetes in Australian primary care. | 17309401 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To examine the frequency of dyslipidaemia and treatment with lipid-lowering drugs in patients with type 2 diabetes managed in Australian primary care. | 17309401 |
| Malignant neoplasm of liver, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | This study implies that glucose intolerance may be an independent risk factor for liver cancer. | 17310595 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) has been consistently associated with obesity and insulin resistance. | 17311652 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Subjects with NASH had more severe insulin resistance when compared to those with simple fatty liver. | 17311652 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance is higher in subjects with NASH versus those with simple fatty liver. | 17311652 |
| Hepatitis C, HIV Infections | Deregulated Nutrient Sensing | Hepatitis C virus infection is associated with insulin resistance among older adults with or at risk of HIV infection. | 17314526 |
| Communicable Diseases, Hepatitis C, HIV Infections | Deregulated Nutrient Sensing | To determine the associations of hepatitis C virus (HCV) infection with insulin resistance and abnormal glucose tolerance in a cohort of older adults with or at risk of HIV infection. | 17314526 |
| Weight Gain, Autoimmune Diseases, Demographics Domain, Kidney Failure | Deregulated Nutrient Sensing | Important in this connection is the so-called 'accelerator hypothesis', which postulates a common basis for both type-I and type-2 DM with genetic predisposition, insulin resistance (caused by rapid weight gain) and autoimmunity, leading to beta-cell insufficiency, as 'accelerators'. | 17315492 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Diabetes and atherosclerosis are burgeoning health problems complicating obesity-associated insulin resistance (IR). | 17316097 |
| Cushing Syndrome, Polycystic Ovary Syndrome, Adrenal Cortical Adenoma | Deregulated Nutrient Sensing | Unilateral adrenalectomy improves insulin resistance and polycystic ovaries in a middle-aged woman with virilizing adrenocortical adenoma complicated with Cushing's syndrome. | 17318025 |
| Hyperandrogenism | Deregulated Nutrient Sensing | Clinical signs of insulin resistance are often present: acanthosis nigricans, signs of hyperandrogenism. | 17320032 |
| Lipodystrophy, Pancreatitis, Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | All lipodystrophies are associated with dysmetabolic alterations with insulin resistance, altered glucose tolerance or diabetes and hypertriglyceridemia leading to a risk of acute pancreatitis. | 17320032 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The association between leptin and incident diabetes is mediated by insulin resistance. | 17322479 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | By contrast, the positive association between IL-6 and diabetes appeared to be independent of obesity and insulin resistance. | 17322479 |
| Tumor necrosis, Obesity | Deregulated Nutrient Sensing | Tumour necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine which has been closely linked to obesity and insulin resistance. | 17322487 |
| Refractory anemias, Simultaneous | Deregulated Nutrient Sensing | This finding may implicate that TNFalpha blockade causes better glycaemic control in RA patients with concomitant diabetes, possibly by improving insulin resistance. | 17322487 |
| Sleep Apnea Syndromes, Acromegaly, Hypertension, CTCAE | Deregulated Nutrient Sensing | Sleep apnoea syndrome (SAS) is common in acromegaly and both diseases are independently associated with hypertension and insulin resistance contributing to increased morbidity and mortality. | 17322492 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Ten patients had a homeostasis assessment model score > or = 4 indicating insulin resistance and one had diabetes mellitus requiring insulin. | 17322492 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Importantly, a marked reduction of GH excess by transsphenoidal adenomectomy may cure SAS and improve insulin resistance and hypertension. | 17322492 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We tested the extent to which altered plasma adipokine levels may contribute to the increased carotid artery intima-media thickness (IMT) associated with type 2 diabetes mellitus and with male gender, independently of conventional cardiovascular risk factors, insulin resistance, and plasma C-reactive protein (CRP). | 17322499 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptor (PPAR)-gamma, a member of the nuclear hormone receptor family, which is involved in the differentiation of adipose tissue, is reported to be associated with the pathogenesis of type 2 diabetes mellitus, insulin resistance and atherosclerosis. | 17322631 |
| Androgenetic Alopecia | Deregulated Nutrient Sensing | The presence of insulin resistance and comparison of various insulin sensivity indices in women with androgenetic alopecia. | 17324822 |
| Dyslipidemias, Failure (biologic function) | Deregulated Nutrient Sensing | Failure to be at goal was common even among those with previously diagnosed dyslipidemia (159/527, 30%) and those taking lipid-lowering agents (LLA) (71/370, 19%). | 17325272 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Many patients hospitalized with ischemic stroke/TIA, including those with known dyslipidemia and those taking lipid lowering agents, have measured low-density lipoprotein (LDL) that is higher than recommended by national guidelines. | 17325272 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease. | 17327326 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Dual ET(A)+ET(B) receptor blockade acutely enhances insulin sensitivity in patients with insulin resistance and coronary artery disease, indicating an important role for endogenous ET-1. | 17327326 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Here, we investigated POPs and insulin resistance, a frequent pathogenic precursor of type 2 diabetes. | 17327331 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | These findings, coupled with those concerning diabetes prevalence, suggest that OC pesticides and nondioxin-like PCBs may be associated with type 2 diabetes risk by increasing insulin resistance, and POPs may interact with obesity to increase the risk of type 2 diabetes. | 17327331 |
| Lipodystrophy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Analysis of genetic variation in Akt2/PKB-beta in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. | 17327441 |
| Lipodystrophy | Deregulated Nutrient Sensing | In summary, although heterozygous loss-of- function mutations in AKT2 can cause a syndrome of severe insulin resistance and lipodystrophy in humans, such mutations are uncommon causes of these syndromes. | 17327441 |
| Lipodystrophy, Diabetes Mellitus | Deregulated Nutrient Sensing | Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin resistance and diabetes. | 17327460 |
| Obesity, Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance has been found to increase the risk of NASH, and obesity, and decreased levels of adiponectin are important factors in determining the severity of insulin resistance. | 17331160 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Ten percent, 26% and 73% of people with hyperglycemia, hypertension and dyslipidemia, respectively, were not on medications. | 17331807 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Most patients treated with either insulin or oral antidiabetic agents were on monotherapy as were those treated for hypertension and dyslipidemia. | 17331807 |
| Hyperandrogenism | Deregulated Nutrient Sensing | These findings are relevant to understanding the pathogenesis of insulin resistance in hyperandrogenic women. | 17332526 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Among women, TC and TG were strongly associated with age, body mass index (BMI) and family history of dyslipidemia. | 17333747 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | More emphasis should be placed on understanding the epidemiology of hypercholesterolemia and other dyslipidemias in Thai men and women. | 17333747 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Other variables commonly associated with type 2 diabetes, such as elevated BMI, hypertension or dyslipidaemia, did not independently contribute to the variance in hippocampal volume. | 17334649 |
| Mucoepidermoid Carcinoma | Deregulated Nutrient Sensing | MECT1, TORC1, or WAMTP1) to the Notch coactivator MAML2 is a characteristic feature of low-grade mucoepidermoid carcinomas of salivary and bronchial glands. | 17334997 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Low HDL-cholesterol is common in European Type 2 diabetic patients receiving treatment for dyslipidaemia: data from a pan-European survey. | 17335463 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | To measure the prevalence of low high-density lipoprotein (HDL)-cholesterol (men < 1.03 mmol/l; women < 1.29 mmol/l) in European Type 2 diabetic patients receiving treatment for dyslipidaemia. | 17335463 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The pan-European Survey of HDL-cholesterol measured lipids and other cardiovascular risk factors in 3866 patients with Type 2 diabetes and 4436 non-diabetic patients undergoing treatment for dyslipidaemia in 11 European countries. | 17335463 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Also endothelium-independent vasodilation (EIDV) induced by intra-brachial infusion of sodium nitroprusside was impaired in subjects with MetS and in insulin resistance. | 17335830 |
| Chronic Kidney Insufficiency, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | A potentially modifiable risk factor for cardiovascular disease in patients with mild chronic renal insufficiency is dyslipidemia. | 17336698 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance in liver cirrhosis is not associated with circulating retinol-binding protein 4. | 17337499 |
| diabetic | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4) has been identified as a novel adipokine mediating systemic insulin resistance, and elevated serum RBP4 indicates overt or impending insulin resistance in lean, obese, and type 2 diabetic subjects. | 17337499 |
| Chronic liver disease, Lymphoproliferative Disorder of the Skin, Liver Cirrhosis | Deregulated Nutrient Sensing | As insulin resistance is present in nearly all patients with liver cirrhosis, we evaluated RBP4 in patients with chronic liver disease (CLD). | 17337499 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Liver Cirrhosis | Deregulated Nutrient Sensing | RBP4 appears, unlike in obesity or type 2 diabetes, not to be a relevant systemic factor in the pathogenesis of insulin resistance in liver cirrhosis. | 17337499 |
| diabetic | Deregulated Nutrient Sensing | Insulin supplementation in diabetic subjects with CFTR deltaF508 mutation seems a rational therapy for consideration, although this does not preclude that therapy directed toward insulin resistance could also interact. | 17337503 |
| Crex | Deregulated Nutrient Sensing | Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05). | 17341128 |
| Dyslipidemias | Deregulated Nutrient Sensing | Among the type 2 diabetics, 68.8% had high blood pressure, and 98.2% had dyslipidemia. | 17341330 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The average number of medications that the patients were taking to treat type 2 diabetes was 1.3; to treat high blood pressure, 1.9; and to treat dyslipidemia, 0.6. | 17341330 |
| Dyslipidemias, Retinal Diseases, Kidney Diseases | Deregulated Nutrient Sensing | Among the study population in Medellin, the three chronic complications with the greatest impact on prognosis and health care costs of the diabetics were nephropathy, retinopathy, and dyslipidemia. | 17341330 |
| Dyslipidemias | Deregulated Nutrient Sensing | Serum lipid levels of the two groups were all close to the proper scopes of Principles for the prevention of dyslipidemia recommended by dyslipemia group of the editorial board of Chinese Journal of Cardiology. | 17343187 |
| Infertility, Prostate Cancer Outcomes Study, Hirsutism, Weight decreased, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Insulin resistance, infertility, and hirsutism, common characteristics of polycystic ovary syndrome (PCOS), improve with even modest weight loss. | 17344488 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, ischemic heart disease and dyslipidemia were found in 59.4%, 18.9% and 11.3% respectively. | 17344774 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Accumulating evidence suggests that energy regulation, particularly insulin resistance, may influence breast cancer risk. | 17348446 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It has been suggested that Japanese subjects categorized as having normal weight (body mass index [BMI]<25.0) as defined by WHO (2000) have a tendency toward increased incidence of dyslipidemia and diabetes. | 17350486 |
| Hepatobiliary Disorder, Dyslipidemias | Deregulated Nutrient Sensing | Although we did not determine the cutoffs of the upper normal limits for AST, ALT, and GGT levels, we would suggest screening asymptomatic patients with dyslipidemia and also subjects with a family history of liver disease. | 17352018 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Among components of MS, serum GGT may be more associated with dyslipidemia and abnormal glucose tolerance, suggesting that serum GGT has more relationship with hepatic insulin resistance regardless of non-alcoholic fatty liver disease. | 17353063 |
| Obesity | Deregulated Nutrient Sensing | Association between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians. | 17353152 |
| Obesity | Deregulated Nutrient Sensing | Anthropometric markers of obesity are simple means that may be used as markers of cardiovascular risk and insulin resistance. | 17353152 |
| Lupus Erythematosus | Deregulated Nutrient Sensing | Type B insulin resistance syndrome associated with systemic lupus erythematosus. | 17360301 |
| Lupus Erythematosus | Deregulated Nutrient Sensing | To document a case of type B insulin resistance syndrome associated with systemic lupus erythematosus. | 17360301 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Of these, some require glucose intolerance and others require obesity for the diagnosis. | 17363755 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In a previous study, regular aerobic physical activity in overweight/obese patients with type 2 diabetes mellitus was found to have significant beneficial effects on glycemic control, insulin resistance, cardiovascular risk factors, and oxidative stress. | 17365936 |
| Microalbuminuria, diabetic | Deregulated Nutrient Sensing | The prevalence of microalbuminuria tended to decrease after six months of aerobic exercise in type 2 diabetic patients, independently of any improvement in insulin resistance and oxidative stress parameters. | 17365936 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Effects of rosuvastatin on lipids, lipoproteins and apolipoproteins in the dyslipidaemia of diabetes. | 17367312 |
| Hyperhomocysteinemia | Deregulated Nutrient Sensing | The present study was undertaken to evaluate the impact of impaired fasting glucose (IFG), insulin resistance (IR) and hyperhomocysteinaemia (Hhcy) on cognitive function (CF) in a sample of non-diabetic elderly subjects. | 17367706 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. | 17372899 |
| Atherosclerosis | Deregulated Nutrient Sensing | Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis. | 17374708 |
| Fever, CTCAE | Deregulated Nutrient Sensing | LPS induced fever, blood, and adipose TNF and IL-6 and increased homeostasis model assessment of insulin resistance. | 17374708 |
| Hypertension, CTCAE, Depression, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Logistic regression was used to adjust for factors that might be associated with switching (dose, age and the presence of hypertension, dyslipidaemia, diabetes or depression). | 17378846 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Insulin resistance may be linked to endothelial dysfunction by several mechanisms, including disturbances in signaling pathways common to both insulin action and NO production. | 17379002 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, may contribute to endothelial dysfunction, and elevated ADMA levels have been associated with both insulin levels and the degree of insulin resistance. | 17379002 |
| Abnormal gastric motility | Deregulated Nutrient Sensing | In a gastric emptying test by external ultrasonography, gastric emptying activity was significantly decreased in subjects with a high HOMA-R. We conclude that insulin resistance induces abnormal gastric motility. | 17380029 |
| Abnormal gastric motility | Deregulated Nutrient Sensing | Though abnormal gastric motility is related to HOMA-R, the findings herein suggest that incretin, showing insulin resistance, or an adipocyokine might be related to the differences in EGG in both groups. | 17380029 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia. | 17380302 |
| Hyperlipidemia, Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Thioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic dyslipidaemia, since TXNIP is the strongest glucose-responsive gene in pancreatic B-cells, TXNIP deficiency in a mouse model is associated with hyperlipidaemia and TXNIP is located in the 1q21-1q23 chromosomal Type 2 diabetes mellitus (DM) locus. | 17381501 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Although documented traditional cardiovascular risk factors (hypertension, diabetes, smoking, and dyslipidemia) increase the risk of developing coronary artery disease, their influence on the treatments and outcomes of patients with non-ST-segment elevation myocardial infarction (NSTEMI) has not been fully elucidated. | 17383286 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance is associated with increased risk of major cardiovascular events in patients with preexisting coronary artery disease. | 17383294 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance per se is an independent risk factor for cardiovascular events and new diabetes in patients with preexisting coronary artery disease. | 17383294 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adipocyte hormones, resistin and adiponectin are implicated in insulin resistance and atherosclerosis. | 17383891 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Subjects with CKD have increased insulin levels and insulin resistance index (IRI). | 17383891 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The insulin secretion/insulin resistance index is useful as a predictor of future development of type 2 diabetes. | 17384342 |
| Obesity | Deregulated Nutrient Sensing | Central obesity is associated with insulin resistance through factors that are not fully understood. | 17384344 |
| Obesity | Deregulated Nutrient Sensing | Resistin is derived from fat tissue in rodents, and serum levels are elevated in animal models of obesity and insulin resistance. | 17384443 |
| Blood Clot, Dyslipidemias | Deregulated Nutrient Sensing | The child had been on dialysis, calcitriol, calcium carbonate, and presented dyslipidemia and calcified thrombi in various vessels and organs in the course of his condition. | 17384823 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Only 64.7% of the respondents reported that they seek to determine the presence of diabetes mellitus, and 56.4% check for dyslipidemia. | 17384840 |
| diabetic | Deregulated Nutrient Sensing | The insulin resistance index progressively increased when the glucose tolerance stage changed from NGT through diabetic subjects. | 17385686 |
| Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are the predominant features in the deterioration of glucose tolerance in Thais. | 17385686 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Evaluation of insulin resistance and sodium sensitivity in normotensive offspring of hypertensive individuals. | 17386322 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Sodium sensitivity (SS) and insulin resistance (IR) might be a common link in the pathogenesis of essential hypertension. | 17386322 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Endothelial dysfunction is related to insulin resistance and inflammatory biomarker levels in obese prepubertal children. | 17389466 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The recent observations that Peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1A) is responsible for the induction of reactive oxygen species (ROS) detoxifying agents and that ROS triggers insulin resistance, support the role that this gene could play in the onset of Type 2 diabetes mellitus (T2DM). | 17390150 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | IGT, insulin resistance and type 2 diabetes are far more common in obese Turkish children than previously thought. | 17391156 |
| Sandawe language | Deregulated Nutrient Sensing | Sagittal abdominal diameter (SAD), a simple marker of intra-abdominal fat, predicts insulin resistance and cardiovascular mortality in men. | 17391519 |
| Sandawe language | Deregulated Nutrient Sensing | Overall, SAD showed a slightly higher correlation with most cardiovascular risk factors, especially insulin resistance, insulin, CRP, apolipoprotein B and triglycerides (all P-values < 0.01) than other anthropometric measures. | 17391519 |
| Sandawe language | Deregulated Nutrient Sensing | SAD explained a greater proportion of the variation of insulin resistance and CRP levels, even independently of the other anthropometric measures. | 17391519 |
| Sandawe language, Inflammation | Deregulated Nutrient Sensing | SAD identifies insulin resistance, subclinical inflammation or raised serum lipids in a Swedish population with a large proportion of immigrant women from the Middle East. | 17391519 |
| Cereals, Inflammation, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Whole grain intake and its cross-sectional association with obesity, insulin resistance, inflammation, diabetes and subclinical CVD: The MESA Study. | 17391554 |
| Cereals, Inflammation, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Concordant with previous research, whole grain intake was inversely associated with obesity, insulin resistance, inflammation and elevated fasting glucose or newly diagnosed diabetes. | 17391554 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Our study shows that in severely obese, non-diabetic, hyperinsulinaemic patients undergoing a nutritional programme, rosiglitazone is more effective than metformin in producing favourable changes in fasting-based indexes of glucose metabolism, with a reduction of both insulin resistance and hyperinsulinaemia. | 17394563 |
| Dyslipidemias, Atherosclerosis, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Atherosclerosis may also participate in a feed-forward cycle as aging, diabetes, dyslipidemia, and hypertension may also represent independent downstream consequences of global sympathetic bias. | 17400398 |
| Obesity | Deregulated Nutrient Sensing | sP-selectin plasma levels in obesity: association with insulin resistance and related metabolic and prothrombotic factors. | 17400434 |
| Cardiovascular Diseases, Dyslipidemias, Hypothalamo-Hypophyseal System, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Cardiovascular disease, hypertension, dyslipidaemia and obesity in patients with hypothalamic-pituitary disease. | 17403957 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Of the 152 patients, 36.8% had treated hypertension and 28.2% had treated dyslipidaemia. | 17403957 |
| Obesity | Deregulated Nutrient Sensing | The raising prevalence of obesity among children increases the risk of insulin resistance and its adverse metabolic consequences. | 17406738 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The PPARgamma Pro12Ala polymorphism has been associated in several studies with a decreased risk of obesity, type 2 diabetes and insulin resistance. | 17408525 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | An increase in association in men with several cardiovascular risk factors (smoker, dyslipidemia and hypertension) was also observed. | 17409181 |
| Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive (finding) | Deregulated Nutrient Sensing | Although the prevalences of grades I and II HR were higher and grade 0 HR was lower in the hypertensive group, respectively (P < 0.001 for all), differences according to obesity, diabetes mellitus, hypertriglyceridemia (P < 0.001 for all), and dyslipidemia (P < 0.01) were also significant between the 2 groups. | 17409584 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Independent correlates of in-hospital mortality were untreated dyslipidaemia, advanced age, diabetes, and low blood pressure. | 17412730 |
| Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disorders | Deregulated Nutrient Sensing | We tested the hypothesis that increased abdominal visceral accumulation (VFA) is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients not receiving insulin treatment. | 17415564 |
| Depressed mood, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results demonstrate that the level of VFA is associated with depressed cardiovascular autonomic function and insulin resistance in patients with type 2 diabetes mellitus. | 17415564 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and associated factors among the hypertensive rural chinese population. | 17416291 |
| Cessation of life, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia plays a crucial rule in the development of cardiovascular disease, which has become the leading cause of death in most developed countries as well as in developing countries. | 17416291 |
| Hypertensive (finding), Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | This study demonstrated that the prevalence of dyslipidemia was relatively high among rural hypertensive patients in China and there were many modifiable risk factors for dyslipidemia such as hypertension, weight, and impaired glucose metabolism. | 17416291 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | To prevent dyslipidemia and to reduce the increasing burden of cardiovascular disease in rural areas with the undeveloped economy of China, the first aim for us is to reduce these risk factors. | 17416291 |
| Adenoma of large intestine | Deregulated Nutrient Sensing | Insulin resistance-related genes and advanced left-sided colorectal adenoma. | 17416760 |
| Colorectal Neoplasms | Deregulated Nutrient Sensing | Insulin resistance has been linked with colorectal neoplasia through a number of mechanistic and observational studies. | 17416760 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance recently has been reported to play a major role in nonalcoholic fatty liver disease (NAFLD). | 17419265 |
| Fatty Liver | Deregulated Nutrient Sensing | We evaluated the influence of fertility on fatty liver injury in fertile and postmenopausal women with insulin resistance. | 17419265 |
| Nonalcoholic Steatohepatitis, Liver damage, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | We demonstrate that fertility is an important factor in fatty liver damage of NAFLD with insulin resistance, suggesting that estrogen may exacerbate nonalcoholic steatohepatitis. | 17419265 |
| Sleep-Disordered Breathing, Glucose Intolerance (disease), Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the association between sleep-disordered breathing (SDB) and obesity, diabetes and glucose intolerance among middle-aged men and women in Finland. | 17419721 |
| Sleep-Disordered Breathing, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustments for age, body mass index, smoking and central nervous system-affecting medication, SDB was independently associated with diabetes and glucose intolerance in men, but not in women. | 17419721 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Among individuals with T2DM, cortisol levels during the DEX/CRH test were positively associated with glycosylated hemoglobin (P = 0.05), independent of age, body mass index, hypertension, and dyslipidemia. | 17426095 |
| Atherosclerosis | Deregulated Nutrient Sensing | Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. | 17429060 |
| Hyperglycemia, Impaired T cell function | Deregulated Nutrient Sensing | ET-1 is also a mediator that is elevated in conditions such as insulin resistance, hyperglycemia, oxidative stress, and endothelial cell dysfunction. | 17429733 |
| Myocardial Contraction, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | However, diabetes, hypertension, dyslipidemia, myocardial infraction, and obesity have not had such effects. | 17433083 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The medical history concerning diabetes mellitus, arterial hypertension, dyslipidaemia, smoking and obesity was taken from every participant. | 17436151 |
| Complications of Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim was to investigate the association between RBP4 and various markers related to insulin resistance and diabetic complications in type 2 diabetic patients. | 17440021 |
| Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | The current study shows that RBP4 is associated with variables related to insulin resistance and diabetic complications. | 17440021 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus. | 17440034 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is typically more severe in obese individuals with type 2 diabetes (T2DM) than in similarly obese non-diabetics but whether there are group differences in body composition and whether such differences contribute to the more severe IR of T2DM is uncertain. | 17440034 |
| Colorectal Neoplasms | Deregulated Nutrient Sensing | Insulinlike growth factor I receptor and estrogen receptor beta expressions are inversely correlated in colorectal neoplasms and affected by the insulin resistance syndrome. | 17442373 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | The results suggest the combined effect of IGF-I and estrogens in colorectal cancer, with a distinctive role in individuals with the insulin resistance syndrome. | 17442373 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | uPAR MFI Index was increased from 0.78 +/- 0.86 in control group to 1.91 +/- 1.97 and 3.33 +/- 2.52 in dyslipidemia group and hypertension + obesity group, respectively, P<0.05. | 17445414 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidemia and obesity may contribute to the increase of uPAR expression. | 17445414 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our findings suggest that the -238G>A and -308G>A polymorphisms of TNF-alpha alter circulating free fatty acids and insulin resistance in obese subjects with type 2 diabetes mellitus. | 17445540 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Lack of association of CPT1A polymorphisms or haplotypes on hepatic lipid content or insulin resistance in Japanese individuals with type 2 diabetes mellitus. | 17445541 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Accumulation of fat in the liver is associated with insulin resistance and type 2 diabetes mellitus. | 17445541 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We have now investigated the contribution of the CPT1A locus to hepatic lipid content (HLC), insulin resistance, and susceptibility to type 2 diabetes mellitus. | 17445541 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Neither haplotypes nor SNPs of CPT1A were found to be associated either with susceptibility to type 2 diabetes mellitus or with HLC or insulin resistance in type 2 diabetic patients. | 17445541 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Regression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndrome. | 17445543 |
| Hypoglycemia | Deregulated Nutrient Sensing | Autoantibodies directed against specific epitopes in the insulin receptor are rarely the cause of either recurrent hypoglycemia or a severe form of insulin resistance (type B insulin resistance). | 17445543 |
| Autoimmune Diseases | Deregulated Nutrient Sensing | Type B insulin resistance occurs more commonly in women of African heritage and is frequently associated with a history of other autoimmune diseases. | 17445543 |
| Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | NT-pro-BNP remained predictive of total and cardiovascular mortality after accounting for age, sex, diabetes mellitus, body mass index, smoking, hypertension, dyslipidemia, glomerular filtration rate, presence or absence of CAD on angiography, cardiovascular medication, revascularization at baseline, clinical signs of heart failure, LV systolic function, and C-reactive protein. | 17446333 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceio, north-eastern Brazil. | 17446818 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | To test the hypothesis that short stature is associated with abdominal obesity, insulin resistance and lipid profile changes. | 17446818 |
| Overweight | Deregulated Nutrient Sensing | Short stature, when associated with overweight, is a risk factor for increased insulin resistance and alterations in lipid profile. | 17446818 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance as predictor of the angiographic severity and extent of coronary artery disease. | 17453676 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance (IR) is frequently observed in patients with coronary artery disease (CAD). | 17453676 |
| Microalbuminuria, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Eighty-two patients with T2DM without symptoms of CAD, and with >or=1 CV risk factor (hypertension, dyslipidaemia, premature familial CAD, smoking or microalbuminuria) underwent a diagnostic stress test and coronary angiography irrespective of stress test results. | 17454845 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The HIV cohort had significantly higher proportions of hypertension (21.2 vs. 15.9%), diabetes (11.5 vs. 6.6%), and dyslipidemia (23.3 vs. 17.6%) than the non-HIV cohort (P < 0.0001 for each comparison). | 17456578 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. | 17457380 |
| Iron-Refractory Iron Deficiency Anemia, Glucose Intolerance (disease), Hypertension, CTCAE, Retinal Diseases | Deregulated Nutrient Sensing | He was known for arterial hypertension (risk factor), mild microcytic anaemia and mild glucose intolerance, which may be responsible for some unusual features of the retinopathy. | 17458812 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obese type 2 diabetes is recently increasing in Korea, indicating a shift from insulin secretory defects to insulin resistance. | 17459510 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes. | 17460368 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, pioglitazone was superior to metformin for the improvement of insulin resistance and adiponectin, and both drugs were equally effective in reducing vWF and aldosterone in subjects with IGT and early diabetes. | 17460368 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | In conclusion, in contrast with the reports that telmisartan may decrease insulin resistance by an effect associated with its molecular structure, 8 weeks of telmisartan treatment in the present study had a neutral effect on insulin resistance in hypertensive MetS patients, and similar results were obtained for losartan. | 17460371 |
| Hypertension, CTCAE, Ventricular hypertrophy | Deregulated Nutrient Sensing | High-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension. | 17460382 |
| Diabetic Nephropathy, Dyslipidemias, Kidney Failure, Chronic | Deregulated Nutrient Sensing | The remarkably high level of apoB48 in diabetic ESRD seems to be attributable to dyslipidemia induced by both diabetic nephropathy and ESRD. | 17462654 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Further, we propose that CA activity is a good candidate for a biomarker of diabetes mellitus for the early detection of insulin resistance because the CA activity variation was proportional to the severity of the diabetes. | 17464559 |
| Cardiac dysfunction, Myocardium | Deregulated Nutrient Sensing | Insulin resistance is associated with various cardiac dysfunctions both molecularly and clinically, including cardiac muscle relaxation and blood flow. | 17467109 |
| Heart failure | Deregulated Nutrient Sensing | Although, these dysfunctions result in heart failure, relationship between insulin resistance and severity of heart failure is not well studied yet. | 17467109 |
| Chronic heart failure | Deregulated Nutrient Sensing | Insulin resistance seems to be one of the important targets in managing the chronic heart failure. | 17467109 |
| diabetic | Deregulated Nutrient Sensing | Furthermore, there is evidence to suggest that testosterone replacement therapy reduces insulin resistance and visceral adiposity in type 2 diabetic men. | 17468196 |
| Kidney Failure, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance may contribute to cardiovascular disease and the progression of renal insufficiency in patients with chronic kidney disease (CKD). | 17468355 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Systolic hypertension, Coronary heart disease, Diabetes Mellitus, Cerebrovascular accident, Heart failure, Depression, CTCAE, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity and depression are two major diseases which are associated with many other health problems such as hypertension, dyslipidemia, diabetes mellitus, coronary heart disease, stroke, myocardial infarction, heart failure in patients with systolic hypertension, low bone mineral density and increased mortality. | 17470289 |
| Obesity, Abdominal, Cardiovascular Diseases, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Low testosterone correlates with such risk factors of cardiovascular diseases as dyslipidemia, atherosclerosis, low fibrinolysis, insulin resistance and abdominal obesity. | 17472002 |
| Glucose Intolerance (disease), Atherosclerosis | Deregulated Nutrient Sensing | Glucose intolerance and insulin resistance/hyperinsulinemia are thought to influence the progression of atherosclerosis. | 17473485 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Recently, the frequency of patients who have glucose intolerance has been increasing in Japan. | 17473485 |
| Glucose Intolerance (disease), Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The rate of glucose intolerance and the levels of post-prandial glucose and insulin were high in the CHD group. | 17473485 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Glucagon plays an important role in postprandial hyperglycemia in type 2 diabetes (T2DM), and coexists with insulin resistance and impaired fibrinolysis. | 17473573 |
| Nonalcoholic Steatohepatitis, Dyslipidemias, Liver Cirrhosis, Williams Syndrome | Deregulated Nutrient Sensing | O verproduction of types I and III collagen and nonalcoholic steatohepatitis secondary to insulin resistance and dyslipidemia possibly contribute to cirrhosis in WS. | 17476199 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFalpha therapy. | 17476613 |
| Refractory anemias | Deregulated Nutrient Sensing | Patients with RA had marked insulin resistance (glucose infusion rate (GIR) area under the curve (AUC) was 499+/-55 mg/kg in the RA group compared to 710+/-77 mg/kg in the control group; p<0.05). | 17476613 |
| Refractory anemias, Inflammation, Disease remission | Deregulated Nutrient Sensing | RA patients with active disease showed marked insulin resistance that was not influenced by anti-TNFalpha therapy despite a reduction in systemic inflammation during the treatment. | 17476613 |
| Glucose Intolerance (disease), GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | Moreover, glucose intolerance prevalence is lower in the follow-up after the ACS episode. | 17478004 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Fifty percent of patients were men, 32% were diabetic, 70% had hypertension, and 58% had dyslipidemia. | 17478140 |
| Hyperglycemia, Dyslipidemias, diabetic, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | As elderly diabetic patients are usually polymorbid, diabetes mellitus in old age is needed a more comprehensive approach to not only the treatment of hyperglycemia but also of hypertension, dyslipidemia and other associated diseases. | 17481770 |
| Obesity | Deregulated Nutrient Sensing | Regular alcohol consumption improves insulin resistance in healthy Japanese men independent of obesity. | 17482151 |
| Autosome | Deregulated Nutrient Sensing | A mutation in the gamma2 subunit of the AMP activated protein kinase gene (PRKAG2) was identified in the four members of the family, with an autosomal dominant inheritance. | 17483151 |
| Hyperlipidemia, Partial lipodystrophy, Dyslipidemias, USF1 wt Allele, Diabetes Mellitus, Non-Insulin-Dependent, Disease | Deregulated Nutrient Sensing | Interestingly, the gene for CRABP-II is located on chromosome 1q21-23, which is a region that has been linked with disorders such as familial combined hyperlipidemia (FCHL), type 2 diabetes mellitus, and partial lipodystrophy, all of which are characterized by dyslipidemia. | 17484622 |
| Peripheral Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | The type of dyslipidemia in patients with peripheral arterial disease (PAD) is still ill defined. | 17485096 |
| TG gene, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone hydrochloride produced beneficial effects on dyslipidemia in patients with type 2 diabetes, compared with the baseline and the glibenclamide group, as demonstrated by increases in high-density lipoprotein cholesterol (HDL-C) levels and low-density lipoprotein cholesterol (LDL) particle size, a fall in TG levels, and an increased ratio of visceral to subcutaneous fat volumes (V/S). | 17485893 |
| Glucose Intolerance (disease), Prostate carcinoma | Deregulated Nutrient Sensing | Glucose intolerance during hormonal therapy for prostate cancer. | 17486109 |
| Glucose Intolerance (disease), Haiti, Structure of posterior cerebral artery | Deregulated Nutrient Sensing | Therefore, glucose intolerance should be considered during HT for PCa. | 17486109 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Preventing cardiovascular disease among Canadians: what are the potential benefits of treating hypertension or dyslipidemia? | 17487292 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Treatments for hypertension and dyslipidemia to prevent the development of cardiovascular disease compete for the same finite number of health care dollars. | 17487292 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Treating dyslipidemia was associated with an average increased life expectancy of 1.67 years and 1.81 years of life free of cardiovascular disease. | 17487292 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The potential benefits associated with treating hypertension or dyslipidemia to prevent cardiovascular disease are substantial. | 17487292 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | However, compared with hypertension guidelines, dyslipidemia guidelines target higher-risk patients. | 17487292 |
| Dyslipidemias, Peripheral Arterial Diseases | Deregulated Nutrient Sensing | Diagnosis and treatment of dyslipidemia are neglected in patients with peripheral artery disease. | 17487761 |
| Communicable Diseases, Hypocortisolism secondary to another disorder | Deregulated Nutrient Sensing | Insulin resistance declined with adrenal suppression and infection control, and wound healing improved dramatically. | 17490929 |
| Infection | Deregulated Nutrient Sensing | In our patient, substantially increased glucocorticoid levels were associated with severe insulin resistance, retarded wound healing, and persistent infections. | 17490929 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Increased BMI was associated with increased prevalence of diabetes mellitus, hypertension and dyslipidaemia in both studies (p<0.001). | 17493087 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In both studies, prevalence of diabetes mellitus, hypertension and dyslipidaemia occurred across all ranges of BMI, but increased with higher BMI. | 17493087 |
| One Vessel Coronary Disease, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Hypertensive (finding) | Deregulated Nutrient Sensing | The men had severe coronary disease with 69% having a prior myocardial infarction, 90% prior coronary artery bypass graft or percutaneous coronary intervention, 49% with three vessel coronary artery disease, 86% were not candidates for further revascularisation, 71% hypertensive, 83% dyslipidaemia, 42% diabetes mellitus, 75% smoking and 68% using nitrates. | 17493089 |
| Acute Coronary Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Implication of the new low-density lipoprotein goals in dyslipidemia management of patients with acute coronary syndrome. | 17493419 |
| Dyslipidemias, Heart failure, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Current evidence supports statin use in individuals with recognized heart failure and concomitant coronary heart disease, dyslipidemia, or diabetes mellitus. | 17495255 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is involved in glucose intolerance, type 2 diabetes mellitus and hypertension. | 17496462 |
| In-Stent Restenosis Indicator | Deregulated Nutrient Sensing | Remnant-like lipoprotein particle level and insulin resistance are associated with in-stent restenosis in patients with stable angina. | 17496497 |
| Restenosis | Deregulated Nutrient Sensing | Our findings suggest that high serum remnant-like lipoprotein particles cholesterol level, and not insulin resistance may be an independent risk factor on in-stent restenosis in nondiabetic patients with stable angina. | 17496497 |
| icodextrin, Dyslipidemias | Deregulated Nutrient Sensing | No significant difference in serum lipid parameters was found between groups A, B, and C. These results demonstrate the lack of the effect of amino acid or icodextrin-based peritoneal solutions on dyslipidemia of CAPD patients. | 17497445 |
| Cancer-related fatigue | Deregulated Nutrient Sensing | It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. | 17497447 |
| Fatty Liver Disease, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The components of MS (obesity, hypertension, and dyslipidaemia) are associated with the presence of NASH in patients with CH-B. | 17498244 |
| millicurie | Deregulated Nutrient Sensing | Further prospective cohort studies that follow a normal cognitive group and MCI patients with and without insulin resistance are necessary. | 17502006 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Furthermore, SIRT1 down-regulation by small interfering RNA or by pharmacological means increased the sensitivity of androgen-responsive genes to androgen stimulation, enhanced the sensitivity of prostate cancer cell proliferative responses to androgens, and decreased the sensitivity of prostate cancer cells to androgen antagonists. | 17505061 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Collectively, these findings identify SIRT1 as a corepressor of AR and elucidate a new molecular pathway relevant to prostate cancer growth and approaches to therapy. | 17505061 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was defined as two consecutive total cholesterol (TC) values above recommended levels. | 17507323 |
| F11 gene, Dyslipidemias | Deregulated Nutrient Sensing | We found almost a sixfold higher risk of IS in patients with dyslipidaemia and high levels of FXI. | 17511793 |
| F11 gene, Dyslipidemias | Deregulated Nutrient Sensing | Further studies should elucidate the role of FXI in IS and therapeutic approaches should become apparent for patients with dyslipidaemia and high-FXI plasma levels. | 17511793 |
| Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and self-rated symptoms of depression in Swedish women with risk factors for diabetes: the Women's Health in the Lund Area study. | 17512316 |
| Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. | 17512316 |
| Obesity, Abdominal, Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, lifestyle factors such as physical inactivity and abdominal obesity, but not insulin resistance, seem to be related to self-rated symptoms of depression in women with risk factors for diabetes mellitus. | 17512316 |
| Depression, CTCAE | Deregulated Nutrient Sensing | The relationship between insulin resistance and major depression needs to be further examined. | 17512316 |
| Obesity | Deregulated Nutrient Sensing | The aim of this study is to examine when impairment of early-phase insulin secretion occurs and whether it can be related to increase in insulin resistance caused by obesity. | 17512320 |
| Immature, Dyslipidemias | Deregulated Nutrient Sensing | Dominance of smoking and dyslipidemias that are the preventable risk factors in premature CHD patients is an important threat for our community health. | 17513205 |
| Obesity | Deregulated Nutrient Sensing | The present study suggests that increasing rates of obesity among Inuit will have health consequences and that anthropometry is a useful tool to indirectly assess insulin resistance/sensitivity. | 17515252 |
| Acromegaly | Deregulated Nutrient Sensing | Insulin resistance and insulin secretion in non-diabetic acromegalic patients. | 17516294 |
| Refractory anemias, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no significant difference between RA and non-RA subjects in the risk imparted with respect to the other CV risk factors (ie, family cardiac history, hypertension, dyslipidaemia, body mass index, or diabetes mellitus). | 17517756 |
| Dyslipidemias | Deregulated Nutrient Sensing | Effect of ezetimibe monotherapy on the concentration of lipoprotein subfractions in patients with primary dyslipidaemia. | 17519084 |
| Dyslipidemias | Deregulated Nutrient Sensing | Therefore, we evaluated the effect of ezetimibe (a selective cholesterol transport inhibitor) on the concentrations of lipoprotein subfractions in patients with primary dyslipidaemia. | 17519084 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients (n = 50) with primary dyslipidaemias were recruited. | 17519084 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | Metabolic abnormalities related to insulin resistance are also uncommon in this condition. | 17523150 |
| Weight decreased, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance, and weight loss have been associated with changes in hypothalamic-pituitary-adrenal (HPA) axis. | 17526821 |
| ARCN1 gene, Inflammation | Deregulated Nutrient Sensing | Insulin resistance and inflammation - A further systemic complication of COPD. | 17530505 |
| Inflammation | Deregulated Nutrient Sensing | Systemic inflammation in other populations is a factor in atherogenesis and has been associated with insulin resistance. | 17530505 |
| ARCN1 gene, Inflammation | Deregulated Nutrient Sensing | We assessed the association between systemic inflammation and insulin resistance in non-hypoxaemic patients with COPD. | 17530505 |
| Tumor necrosis | Deregulated Nutrient Sensing | Insulin resistance was related to interleukin-6 (IL-6), r=0.276, p=0.039, and tumour necrosis factor alpha soluble receptor I, r=0.351, p=0.008. | 17530505 |
| ARCN1 gene, Inflammation | Deregulated Nutrient Sensing | We demonstrated greater insulin resistance in non-hypoxaemic patients with COPD compared with healthy subjects, which was related to systemic inflammation. | 17530505 |
| Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Cerebrovascular accident | Deregulated Nutrient Sensing | Age, hypertension, dyslipidemia, and atrial fibrillation were independent risk factors for stroke in this cohort. | 17531924 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Relation between insulin resistance and breast cancer among Chilean women. | 17531933 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The association between insulin resistance and breast cancer, however, remains largely unexplored. | 17531933 |
| Inflammation | Deregulated Nutrient Sensing | Secondary outcomes included endothelial-independent glyceryl trinitrate-mediated dilatation (GTNMD), large-artery compliance (C1), and levels of lipids, lipoproteins, and oxidized low-density lipoprotein, as well as markers of insulin resistance and inflammation. | 17533020 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In patients with advanced CKD, atorvastatin is associated with improvement in dyslipidemia and small-artery stiffness, but not endothelial function. | 17533020 |
| Dyslipidemias | Deregulated Nutrient Sensing | For males various modifiable risk factors were associated with the presence of CAD, particularly DM and dyslipidemia. | 17533472 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The profound effect of telmisartan to lower cholesterol suggests a potential use in hypertensive patients with dyslipidemia. | 17533580 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | We found a significant increase (p<0.05) in the hazard of IHD in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other established risk factors, and the structural isoform variations of the ApoE molecule. | 17535270 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Fasting blood glucose was higher in IR subjects ([means +/- SD] 94.1 +/- 8.1 vs. 87.9 +/- 8.2, P < 0.05), indicating a very mild glucose intolerance. | 17536070 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In models using patients without risk factors (hypertension, obesity, smoking or dyslipidaemia ) as a referent group and comparing them to patients with the risk factor and with ID/II, and with DD genotypes, all models (except for smoking) favoured an increasing trend of risk with patients having the risk factor and DD genotype at the highest risk in women. | 17537156 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Similar trends for hypertension and dyslipidaemia were also observed in men. | 17537156 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | In genotype 1 CHC patients, insulin resistance played a significant role in the response to antiviral therapy. | 17540037 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | In CHC patients insulin resistance strongly influences the response to antiviral treatment in patients infected with genotype 1. | 17540037 |
| Prehypertension | Deregulated Nutrient Sensing | Prehypertension and insulin resistance in a nationally representative adult population. | 17541327 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Hypertensive disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension (HTN) and dyslipidemia are major risk factors for coronary heart disease (CHD). | 17541329 |
| Increased insulin level, Chronic Kidney Diseases | Deregulated Nutrient Sensing | We sought to determine the prevalence of hyperinsulinemia and insulin resistance in pediatric patients with chronic kidney disease (CKD) stages 2-4. | 17541791 |
| Increased insulin level, Chronic Kidney Diseases | Deregulated Nutrient Sensing | We conclude that hyperinsulinemia and insulin resistance are frequent in pediatric CKD. | 17541791 |
| Atheroma, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Resistin, a novel adipokine linked to insulin resistance and obesity in rodents, which is derived mainly from macrophages and identified in atheromas in human, has been shown to play a potential role in atherosclerosis. | 17543176 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Insulin resistance-related gene polymorphisms and risk of prostate cancer. | 17548707 |
| Glucose Intolerance (disease), Hypertriglyceridemia, Dental Plaque | Deregulated Nutrient Sensing | The following risk factors were significantly related in univariate logistic models: glucose intolerance and coronary calcified lesions (p = 0.001), and hypertriglycemia and non-calcified plaque lesions (p = 0.048). | 17548955 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Our results suggest that glucose intolerance might be closely related to the presence of coronary calcified lesions among traditional CAD risk factors. | 17548955 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | Prepubertal girls with obesity or insulin resistance are also at risk to develop the full PCOS phenotype after puberty. | 17550211 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | With a mean of two risk factors, the overall incidence of comorbidities was hypertension in 37%, dyslipidaemia in 28%, diabetes in 26%, coronary artery disease in 18% and lower urinary tract symptoms in 46%. | 17552959 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | There are currently 1.85 million reproductive-aged women in the United States with diabetes or glucose intolerance. | 17554614 |
| Atherosclerosis of renal artery, Atherosclerosis | Deregulated Nutrient Sensing | Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. | 17556684 |
| Atherosclerosis | Deregulated Nutrient Sensing | This study evaluated 1178 participants in the Insulin Resistance Atherosclerosis Study. | 17556684 |
| FBN2 wt Allele | Deregulated Nutrient Sensing | The relation between whole-grain intake and CCA IMT remained significant after adjustment for mediating pathways (lipids, adiposity, and insulin resistance), nutrient constituents, and a principal components-derived healthy dietary pattern. | 17556684 |
| Increased insulin level | Deregulated Nutrient Sensing | The patient was diagnosed with severe GH deficiency with modest fasting hyperinsulinemia and insulin resistance and started on GH replacement therapy, an alpha-glucosidase inhibitor (acarbose) and a diet low in simple carbohydrates. | 17556873 |
| Sleep Apnea, Obstructive, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. | 17557769 |
| Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | The effects of continuous positive airway pressure (CPAP) for obstructive sleep apnoea (OSA) on insulin resistance are not clear. | 17557769 |
| Diabetes Mellitus, Non-Insulin-Dependent, Osage language | Deregulated Nutrient Sensing | Therapeutic CPAP does not significantly improve measures of glycaemic control or insulin resistance in men with type 2 diabetes and OSA. | 17557769 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | A negative association between T and insulin resistance as well as impaired glucose intolerance has been demonstrated and in type 2 diabetic men TS improves metabolic parameters. | 17558968 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Although non-alcoholic steatohepatitis (NASH) is generally considered a hepatic manifestation of insulin resistance, there are no reports showing the link of AGE to NASH. | 17559366 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results from a sample of Iranian type 2 diabetes cases and controls provide evidence that the 1484insG genotype of the PTPN1 gene may be associated with insulin resistance and other cardiovascular risk factors in non-diabetic male subjects. | 17560463 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Subjects with obesity and elevated fasting blood glucose are at high risk of developing type 2 diabetes which may be reduced by a dietary intervention leading to an improvement of insulin resistance. | 17562226 |
| Hypertensive (finding), Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Overweight or obesity were present in 82.6% of patients, 97% were hypertensive and 92.6% presented dyslipidemia. | 17564559 |
| Dyslipidemias | Deregulated Nutrient Sensing | To determine the efficacy and safety of adding ezetimibe to maximally tolerated lipid lowering therapy in patients with HIV dyslipidemia. | 17565701 |
| Increased insulin level, Obesity | Deregulated Nutrient Sensing | MCP-1 is likely to participate in obesity, hyperinsulinemia, and insulin resistance in POCS. | 17565837 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Plasma retinol-binding protein 4 (RBP4) may be a new adipokine linked to obesity-induced insulin resistance and type 2 diabetes. | 17568782 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore, further studies evaluating RBP4 as a regulator of systemic insulin resistance and type 2 diabetes will need to take renal function into consideration. | 17568782 |
| SLC16A1 wt Allele | Deregulated Nutrient Sensing | The MCT group showed an across-time reduction in body weight and WC, an increase in serum C-peptide concentration, a reduction in homeostasis model assessment of insulin resistance, and a decrease in serum cholesterol concentration (P < .05, repeated measures). | 17570262 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome. | 17570263 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, metabolic disturbance, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) is an independent risk factor for cardiovascular disease and is a prevalent metabolic disturbance among women with polycystic ovary syndrome (PCOS). | 17570263 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. | 17570985 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In animals, the compound is known to cause insulin resistance, the underlying abnormality in type 2 diabetes mellitus. | 17570985 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Insulin resistance in humans taking oral glucosamine in doses used for osteoarthritis has not been studied. | 17570985 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Our data indicate that persons with underlying poorer insulin sensitivity are at risk for worsening insulin resistance and vascular function with the use of glucosamine in doses used to treat osteoarthritis. | 17570985 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. | 17571165 |
| Muscle (organ) | Deregulated Nutrient Sensing | Insulin resistance in these tissues was associated with reduced insulin-stimulated insulin receptor substrate 1- (IRS-1-) and IRS-2-associated PI3K activity in muscle and liver, respectively. | 17571165 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | There is a beneficial effect on the co-morbid conditions like hypertension and dyslipidemia. | 17571741 |
| Increased insulin level, Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients. | 17575088 |
| Increased insulin level | Deregulated Nutrient Sensing | This study demonstrates a direct relationship between aldosterone, insulin resistance, and hyperinsulinemia in white subjects. | 17575088 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The Barriers to Insulin Treatment Questionnaire appears to be a reliable and valid measure of psychological insulin resistance in patients with type 2 diabetes. | 17575092 |
| Acromegaly, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus is accompanied in some acromegalic patients with insulin resistance. | 17575366 |
| Inflammation, Hypoadiponectinemia, Hypertriglyceridemia, Atherosclerosis | Deregulated Nutrient Sensing | Current findings suggest that relative importance of hypertriglyceridemia and enhanced inflammation, rather than insulin resistance, as the downstream events of hypoadiponectinemia leading to atherosclerosis in the Japanese general population. | 17575367 |
| Amyotrophic Lateral Sclerosis, "Alzheimers Disease", Nerve Degeneration | Deregulated Nutrient Sensing | SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. | 17581637 |
| Amyotrophic Lateral Sclerosis, Neurotoxicity Syndromes, Data types - Address | Deregulated Nutrient Sensing | Here, we report that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults. | 17581637 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | In cell-based models for AD/tauopathies and ALS, SIRT1 and resveratrol, a SIRT1-activating molecule, both promote neuronal survival. | 17581637 |
| Nerve Degeneration | Deregulated Nutrient Sensing | Furthermore, injection of SIRT1 lentivirus in the hippocampus of p25 transgenic mice conferred significant protection against neurodegeneration. | 17581637 |
| Neurodegenerative Disorders | Deregulated Nutrient Sensing | Thus, SIRT1 constitutes a unique molecular link between aging and human neurodegenerative disorders and provides a promising avenue for therapeutic intervention. | 17581637 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Most studies of diet in glucose intolerance and type 2 diabetes have focused on intakes of fat, carbohydrate, fibre, fruits and vegetables. | 17583796 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Counselling on lifestyle changes to address hypertension helps patients reduce risk factors such as smoking, high alcohol consumption, overweight, dyslipidemia, negative stress and physical inactivity. | 17584423 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. | 17586736 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We measured oxidative stress using the ratio of urine 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha) to creatinine and used age- and sex-adjusted regression models to test the association of oxidative stress with insulin resistance in individuals without diabetes and among subgroups at elevated risk of diabetes. | 17586736 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Systemic oxidative stress is associated with insulin resistance in individuals at average or elevated risk of diabetes even after accounting for BMI. | 17586736 |
| Arteriosclerosis | Deregulated Nutrient Sensing | Our results did not confirm the influence of insulin resistance on the development of arterial sclerosis lesions. | 17587749 |
| Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia and type 2 diabetes mellitus (T2DM) increase atherosclerotic coronary heart disease (CHD) risk. | 17588297 |
| Hyperhomocysteinemia, Dyslipidemias, Ischemic stroke, Hypothyroidism | Deregulated Nutrient Sensing | Subclinical hypothyroidism, hyperhomocysteinemia and dyslipidemia: investigating links with ischemic stroke in Turkish patients. | 17588311 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The rate of glucose intolerance, morbidity and mortality were 24.1%, 24.8% and 13.6%, respectively. | 17589925 |
| diabetic | Deregulated Nutrient Sensing | In muscle, resistance to insulin-mediated glucose uptake is thought to underlie the pre-Type 2 diabetic condition. | 17593244 |
| Obesity | Deregulated Nutrient Sensing | Obesity and physical inactivity (silent epidemic) are the dominant causes of insulin resistance. | 17593634 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Thus, precise insulin resistance measurement in individuals at risk for metabolic diseases would support clinical risk stratification. | 17595351 |
| Labor (Childbirth) | Deregulated Nutrient Sensing | However, the gold standard for measuring insulin resistance, the hyperinsulinemic clamp test, is too labor intensive to be performed in large clinical studies/settings. | 17595351 |
| Chronic myocardial ischemia, Electrocardiogram: myocardial infarction (finding), Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia worsens a prognosis in patients with chronic heart ischemic disease, who underwent myocardial infarction. | 17598652 |
| Obesity | Deregulated Nutrient Sensing | When adjusting for this influence, we found a nongenetic negative association between birth weight and glucose tolerance as well as insulin resistance that was partially independent of adult obesity. | 17598817 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Birth weight is nongenetically associated with glucose intolerance in elderly twins, independent of adult obesity. | 17598817 |
| Increased insulin level | Deregulated Nutrient Sensing | The possibility that hyperinsulinemia and/or insulin resistance may directly increase haptoglobin levels has never been tested. | 17598972 |
| Increased insulin level | Deregulated Nutrient Sensing | Higher haptoglobin serum levels seem to be a strong marker of hyperinsulinemia, independently of BMI, body fat distribution, insulin resistance and related parameters. | 17598972 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Female patients presenting with HS should prompt investigations for underlying PCOS and insulin resistance. | 17601419 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Clinically significant macular edema | Deregulated Nutrient Sensing | The study involved 47 patients with type II diabetes mellitus and dyslipidemia, with CSME. | 17605275 |
| Hypertensive (finding), Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Treatment patterns of hypertension and dyslipidaemia in hypertensive patients at higher and lower risk of cardiovascular disease in primary care in the United Kingdom. | 17611550 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Few studies have investigated the presence of dyslipidaemia in hypertensive individuals. | 17611550 |
| Hypertensive (finding), Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | This retrospective cohort study examined treatment patterns for hypertension and dyslipidaemia among hypertensive patients in UK primary care. | 17611550 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We analysed the prevalence of risk factors and the prevalence and incidence of treatment for hypertension, dyslipidaemia and for both conditions between January 1997 and December 2001. | 17611550 |
| Demographics Domain, Arthropathy, Dyslipidemias, Diabetes Mellitus, Hypertensive disease | Deregulated Nutrient Sensing | Presence of diabetes mellitus (DM); high blood pressure (HBP), dyslipidemia and arthropathy were assessed. | 17612378 |
| Dyslipidemias, Pathology | Deregulated Nutrient Sensing | Associated pathologies were present in 80,8% of the studied women: 46,9% (n = 61) with dyslipidemia; 42,3% (n = 55) with HBP; 33,1% (n = 43) with arthropaties; and 16,2% (n = 21) with DM. | 17612378 |
| Hypertensive disease, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Overweight and obese I women showed a higher prevalence of dyslipidemia (56%) and (52%), respectively; while in Obese II and Obese III, 38,7% and 47,1% presented HBP respectively. | 17612378 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | There was a positive correlation (Spearman) among DM, HBP and dyslipidemia (p < 0,05) with age; and significant correlation (Pearson, p < 0,05) between W/H ratio and DM. | 17612378 |
| Hypertensive disease, Dyslipidemias, Pathology, Arthropathy | Deregulated Nutrient Sensing | There was a high prevalence of associated pathologies in the valued women, being the most frequent dyslipidemia, HBP and arthropathy, which are directly proportional with the age and the IC/C. | 17612378 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Rosiglitazone (RSG) has been reported to reduce blood pressure (BP) in patients with type-2 diabetes, but similar effects in non-diabetic people with insulin resistance is less clear. | 17612907 |
| Type 2, Diabetic Retinopathy | Deregulated Nutrient Sensing | A community-based study of the relationship between insulin resistance/beta-cell dysfunction and diabetic retinopathy among type II diabetics in Kinmen, Taiwan. | 17613850 |
| Type 2, Diabetic Retinopathy, Beta-cell dysfunction, GDC Disease Response Terminology | Deregulated Nutrient Sensing | To explore whether insulin resistance and beta-cell dysfunction are both related to diabetic retinopathy (DR) in type II diabetics by using a community-based study in Kinmen, Taiwan. | 17613850 |
| GDC Disease Response Terminology, Beta-cell dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Based on the multiple logistic regression, DR was found to be strongly related to both baseline insulin resistance (IR) and beta-cell dysfunction regardless of duration of diabetes. | 17613850 |
| Diabetic Retinopathy, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Insulin resistance and beta-cell dysfunction are both associated with diabetic retinopathy in type II diabetes. | 17613850 |
| Prostate Cancer Outcomes Study, Dyslipidemias, Obesity, Hypertension, CTCAE, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is commonly associated with insulin resistance, obesity, dyslipidemia and hypertension. | 17616856 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is an important modifiable risk factor for cardiovascular disease (CVD). | 17617298 |
| Dyslipidemias | Deregulated Nutrient Sensing | Studies suggest that dyslipidemia is underdiagnosed and undertreated in Canada. | 17617298 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with dyslipidemia fell mostly into very-high-risk (45.7%) or low-risk (31.1 %) categories for CAD. | 17617298 |
| Hypertension, CTCAE, Coronary Artery Disease, Prostate carcinoma, Dyslipidemias | Deregulated Nutrient Sensing | Coronary artery disease, benign hypertension, and dyslipidemia reduced the odds of late-stage prostate cancer. | 17619718 |
| Diabetic Nephropathy, Dyslipidemias | Deregulated Nutrient Sensing | In recent studies, apolipoprotein E (apo E) genetic polymorphism in association with dyslipidemia have been proposed as the one of the risk factors for the development of diabetic nephropathy. | 17624465 |
| Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Therefore, we aimed for investigating the association among apo E genetic polymorphism, dyslipidemia and the development of diabetic nephropathy in type 2 diabetic patients. | 17624465 |
| Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These data suggest that E4 carrier might be associated with the protection for the development of diabetic nephropathy in type 2 diabetic patients without respect to dyslipidemia. | 17624465 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance in a US population with background exposure to POPs. | 17624515 |
| Sleep Apnea, Obstructive, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity is an important risk factor for obstructive sleep apnoea syndrome (OSAS), insulin resistance and cardiovascular disease. | 17626108 |
| Dyslipidemias | Deregulated Nutrient Sensing | Although tesaglitazar is no longer in clinical development, these data indicate that dual PPARalpha/gamma agonism may be a useful pharmacological approach to improve the atherogenic dyslipidaemia associated with insulin resistance. | 17631296 |
| Psychiatric | Deregulated Nutrient Sensing | Individuals had evaluation of glucose tolerance, insulin resistance (insulin suppression test), lipid concentrations, and psychiatric status before and after switching to aripiprazole for 4 months. | 17632220 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | [The research of the correlation of obstructive sleep apnea-hypopnea syndrome and insulin resistance]. | 17634025 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | To investigate whether obstructive sleep apnea-hypopnea syndrome (OSAHS) is relevant to insulin resistance (IR) and whether it is an independent factor of IR. | 17634025 |
| Obesity | Deregulated Nutrient Sensing | The improvement in insulin resistance was independent of the improvement in obesity. | 17634702 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Insulin resistance is a predictor of cardiovascular mortality in patients with end-stage renal disease. | 17635748 |
| Hyperinsulinism, Cardiovascular Diseases | Deregulated Nutrient Sensing | ARB that ameliorate insulin resistance and hyperinsulinaemia could also provide effective options for preventing cardiovascular disease in patients with MHD. | 17635748 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Alcohol intake, insulin resistance, and abdominal obesity in elderly men. | 17636095 |
| Obesity, Abdominal, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance, insulin secretion, and abdominal obesity are major predictors of diabetes, but the links with alcohol intake remain contradictory because of limited data. | 17636095 |
| Prostate carcinoma | Deregulated Nutrient Sensing | SIRT1 is significantly elevated in mouse and human prostate cancer. | 17638871 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Evidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer. | 17638871 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | To better understand the relationship among SIRT1, energy balance, and cancer, two experiments were done. | 17638871 |
| Prostatic Neoplasms, Neoplasms | Deregulated Nutrient Sensing | Second, immunohistochemistry was done on human prostate tumors to determine if SIRT1 was differentially expressed in tumor cells versus uninvolved cells. | 17638871 |
| Carcinogenesis | Deregulated Nutrient Sensing | Results show that SIRT1 is not increased in the dorsolateral prostate (DLP) of calorie-restricted mice during carcinogenesis. | 17638871 |
| Adenocarcinoma | Deregulated Nutrient Sensing | In contrast, when examined in the DLP as a function of pathologic score, SIRT1 was significantly elevated in mice with poorly differentiated adenocarcinomas compared with those with less-advanced disease. | 17638871 |
| Adenocarcinoma of prostate, Neoplasms | Deregulated Nutrient Sensing | HIC-1, which has been shown to regulate SIRT1 levels, was markedly reduced in the same tumors, suggesting that a reduction in HIC-1 may be in part responsible for the increased expression of SIRT1 in prostatic adenocarcinomas. | 17638871 |
| Prostatic Neoplasms, Primary malignant neoplasm | Deregulated Nutrient Sensing | Furthermore, immunostaining of human prostate tumors showed that cancer cells had greater SIRT1 expression than uninvolved cells. | 17638871 |
| Carcinogenesis | Deregulated Nutrient Sensing | In conclusion, DLP SIRT1 expression from calorie-restricted mice was not altered during carcinogenesis. | 17638871 |
| Adenocarcinoma, Prostate carcinoma | Deregulated Nutrient Sensing | However, SIRT1 expression was increased in mice with poorly differentiated adenocarcinomas and in human prostate cancer cells. | 17638871 |
| Prostate carcinoma, Neoplasms | Deregulated Nutrient Sensing | Because SIRT1 may function as a tumor promoter, these results suggest that SIRT1 should be considered as a potential therapeutic target for prostate cancer. | 17638871 |
| Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | This study tested the hypothesis that RBP4 is a marker of insulin resistance and the metabolic syndrome in patients with type 2 diabetes or coronary artery disease (CAD) or in non-diabetic control subjects without CAD. | 17639305 |
| Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Insulin peak, area under the curve for insulin, insulin resistance, insulin sensitivity, and pancreatic beta-cell function were all significant. | 17642423 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes. | 17644622 |
| diabetic | Deregulated Nutrient Sensing | In type 2 diabetic patients, both AUC(IRG) and AUC(CPR) increased with increasing BMI, basal CPR level, and homeostasis model assessment of insulin resistance value. | 17644622 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Intraislet insulin deficiency and alpha-cell insulin resistance may be the primary contributors to this condition in type 1 and type 2 diabetes, respectively. | 17644622 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. | 17646192 |
| Hypercholesterolemia, atherosclerotic | Deregulated Nutrient Sensing | Low apelin levels in hypercholesterolemia seem associated with insulin resistance, which needs to be investigated in larger populations as well as in other atherosclerotic conditions. | 17647139 |
| diabetic | Deregulated Nutrient Sensing | Preheparin lipoprotein lipase mass is a practical marker of insulin resistance in ambulatory type 2 diabetic patients treated with oral hypoglycemic agents. | 17651713 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adipocyte cytokines regulate glucose metabolism and insulin resistance and adiponectin is thought to have a protective effect against atherosclerosis. | 17651832 |
| Increased insulin level, Hyperglycemia | Deregulated Nutrient Sensing | These mutant mice also showed obesity-independent insulin resistance, hyperinsulinemia, impaired glucose tolerance, age-dependent hyperglycemia, and shortened life span. | 17652166 |
| Complication Aspects, Coronary heart disease, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Many HIV-infected patients on highly active antiretroviral therapy (HAART) experience metabolic complications including dyslipidaemia and insulin resistance, which may increase their coronary heart disease (CHD) risk. | 17652317 |
| Kidney Failure, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance and low HDL-cholesterol are also common in chronic kidney disease (CKD), but it is not clear whether they are early or late phenomenons in the development of renal failure. | 17653600 |
| Renal Insufficiency, Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest that even early impairment of renal function may be associated with insulin resistance and dyslipidemia, regardless of renal albumin leakage. | 17653600 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Low HDL-cholesterol (HDL-C) is frequently accompanied by high triacylglycerol levels in diabetic dyslipidaemia, increasing the risk of CHD. | 17653691 |
| Critical Illness | Deregulated Nutrient Sensing | Correlation of calculated indices of insulin resistance (QUICKI and HOMA) with the euglycaemic hyperinsulinaemic clamp technique for evaluating insulin resistance in critically ill patients. | 17655809 |
| Critical Illness | Deregulated Nutrient Sensing | Insulin resistance was measured in 30 critically ill medical patients by the euglycaemic hyperinsulinaemic clamp technique (M-value) as well as calculated using QUICKI and HOMA. | 17655809 |
| Critical Illness | Deregulated Nutrient Sensing | Although QUICKI and HOMA indicated insulin resistance in the critically ill medical patients, both indices did not correlate with the M-value. | 17655809 |
| Critical Illness | Deregulated Nutrient Sensing | Therefore, the euglycaemic hyperinsulinaemic clamp technique remains the gold standard for estimating insulin resistance in critically ill patients. | 17655809 |
| Diabetes Mellitus, Non-Insulin-Dependent, Increased insulin level, Breast Carcinoma | Deregulated Nutrient Sensing | It has been suggested that type 2 diabetes may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. | 17659440 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | These results support the concept that obesity predisposes to hepatic steatosis; but in addition, insulin resistance beyond that induced by obesity alone and a relatively high ratio of truncal-to-lower body fat usually combined with obesity to produce an elevated liver fat content. | 17659597 |
| Hyperhomocystinemia, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, a high homocysteine level is an independent and important risk factor of CAD and the relative risk of CAD conferred by homocystinemia is similar to that of dyslipidemia in the Chinese population at high risk of CAD. | 17659928 |
| Overweight, Insulin resistance syndrome | Deregulated Nutrient Sensing | The prevalence of overweight, high blood pressure and insulin-resistance syndrome was 16.6 %, 3.7 % and 1.2 %, respectively. | 17663905 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In multivariate analysis, allogeneic HSCT (RR: 14.5; P =.003), and at least 2 of 4 cardiovascular risk factors (hypertension, dyslipidemia, diabetes, obesity) (RR: 12.4; P =.02) were associated with a higher incidence of arterial events after HSCT. | 17664354 |
| Lipolysis | Deregulated Nutrient Sensing | Insulin resistance, associated with increased lipolysis, results in a high exposure of nonadipose tissue to lipids. | 17666465 |
| Atherosclerosis | Deregulated Nutrient Sensing | Rate of change and instability in body mass index, insulin resistance, and lipid metabolism as predictors of atherosclerotic vascular disease. | 17666474 |
| Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | The report of a pathogenic mutation (R531Q) in the gene (PRKAG2) encoding the gamma2 subunit of AMP-activated protein kinase (AMPK) in three infants with congenital hypertrophic cardiomyopathy, glycogen storage, and "pseudo PHK deficiency" prompted us to screen this gene in our patient. | 17667862 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy. | 17668875 |
| Obesity, Hypertension, CTCAE, Disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | SA is a common disorder associated with major morbid conditions, including hypertension, obesity, cardiovascular disease, and insulin resistance. | 17669711 |
| Glucose Intolerance (disease), Liver carcinoma, Hepatitis C | Deregulated Nutrient Sensing | Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection. | 17671700 |
| Liver carcinoma, Communicable Diseases, Glucose Intolerance (disease), Hepatitis C, FAM126A gene | Deregulated Nutrient Sensing | Glucose intolerance frequently is found in hepatocellular carcinoma (HCC) patients with hepatitis C virus (HCV) infection; however, the significance of glucose intolerance remains unclear. | 17671700 |
| Glucose Intolerance (disease), Hepatitis C, FAM126A gene | Deregulated Nutrient Sensing | To assess the significance of glucose intolerance, we analyzed 118 HCC patients with HCV infection. | 17671700 |
| Glucose Intolerance (disease), FAM126A gene | Deregulated Nutrient Sensing | In conclusion, this study is the first to demonstrate the significance of glucose intolerance in prognosis of male HCC patients and down-regulation of SHIP2 expression in HCC. | 17671700 |
| Hyperlipidemia, Dyslipidemias, USF1 wt Allele, Coronary Artery Disease | Deregulated Nutrient Sensing | Familial combined hyperlipidemia (FCHL) characterized by high serum total cholesterol and/or triglycerides (TGs) is a common dyslipidemia predisposing to coronary artery disease (CAD). | 17673701 |
| Obesity | Deregulated Nutrient Sensing | In this way, it was possible to cope with the insulin resistance caused by anti-psychotic pharmacotherapy (clozapine) and the obesity which had developed as a result of clozapine. | 17675772 |
| Weight decreased | Deregulated Nutrient Sensing | As seen in our patient metformin therapy causes weight loss and decreases insulin resistance. | 17675772 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Patients in the increasing obesity class had a higher prevalence of diabetes, hypertension and dyslipidemia and were more likely to be women. | 17680619 |
| diabetic | Deregulated Nutrient Sensing | Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. | 17681171 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Abdominal fat accumulation (visceral/hepatic) has been associated with hepatic insulin resistance (IR) in obesity and type 2 diabetes (T2DM). | 17681171 |
| Sleep Apnea, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Treatment for sleep apnea may improve insulin resistance in diabetes mellitus. | 17682308 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Dyslipidemia, often found in type 2 diabetes mellitus (T2DM) patients, plays an important role in the progression of cardiometabolic syndrome. | 17684468 |
| Chronic heart failure | Deregulated Nutrient Sensing | Effect of selective and non-selective beta-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure. | 17694376 |
| Hyperleucinemia, Chronic heart failure, Congestive heart failure | Deregulated Nutrient Sensing | Chronic heart failure (CHF) is characterized by increased insulin resistance and hyperleptinaemia. | 17694376 |
| Congestive heart failure | Deregulated Nutrient Sensing | We aimed to study effects of selective and non-selective beta-blockers on body weight, insulin resistance, plasma concentrations of leptin and resistin in patients with CHF. | 17694376 |
| Hepatitis C, Demographics Domain, Liver Cirrhosis | Deregulated Nutrient Sensing | Cirrhosis of the liver from alcohol and hepatitis C infection, on the other hand, may give rise to insulin resistance or may result in progressive impairment of insulin secretion leading to DM. | 17694770 |
| Glucose Intolerance (disease), Cerebrovascular accident, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and glucose intolerance are highly prevalent after stroke, contributing to worsening cardiovascular disease risk and a predisposition to recurrent stroke. | 17702957 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These preliminary findings suggest that progressive aerobic exercise can reduce insulin resistance and prevent diabetes in hemiparetic stroke survivors. | 17702957 |
| Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | PRINCIPLES AND QUESTIONS UNDER STUDY: The prevalence of overweight is increasing in Swiss children, and they are at increased risk for hypertension and insulin resistance. | 17705105 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | A total of 376 patients with primary dyslipidaemia (209 men), without overt vascular disease, had their cardiovascular risk estimated using the Framingham equation. | 17708367 |
| Rheumatism, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Peripheral Arterial Diseases, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Heart failure, Malignant Neoplasms, Kidney Diseases, Alcohol abuse, Hypertension, CTCAE | Deregulated Nutrient Sensing | Exclusion criteria were diabetes mellitus, hypertension, dyslipidemia, evident stroke, smoking, documented coronary artery disease, history of myocardial infarction, heart failure, acute or chronic infection, malignancy, peripheral artery disease, renal disease, rheumatologic diseases, alcohol abuse, and certain drugs that may affect endothelial function. | 17711428 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | The decreasing order of dyslipidemia prevalence of the two communities was: elevated TG, decreased HDL-C, elevated LDL-C and TC. | 17711685 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia of the two communities was TG and decreased. | 17711685 |
| Ventricular hypertrophy, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertensive (finding) | Deregulated Nutrient Sensing | The sedentary lifestyle, smoking, high body mass index, dyslipidemia were found in 52.5%, 34.4%, 31.8%, 24.5%, and microproteinuria, left ventricular hypertrophy, coronary artery disease and diabetes in 21.0%, 23.6%, 20.1%, 26.7% hypertensive patients, respectively. | 17711690 |
| Hyperglycemia | Deregulated Nutrient Sensing | Insulin resistance is commonly cited as the mechanism for hyperglycemia, a theory supported by the efficacy of insulin- sensitizing medications in reported cases. | 17713311 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Positive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia. | 17714716 |
| Dyslipidemias, Diabetes Mellitus, diabetic | Deregulated Nutrient Sensing | Thailand diabetes registry project: current status of dyslipidemia in Thai diabetic patients. | 17715835 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the prevalence of dyslipidemia in adult Thai type 2 diabetes who attended diabetes clinics in university and tertiary-care hospitals. | 17715835 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The overall prevalence of dyslipidemia found in this population was 73.3%, hypertension was 63.3% and obesity (BMI >25 kg/m2) was 52.6%. | 17717877 |
| Dyslipidemias, Complications of Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of dyslipidemia and hypertension were high in this population, which may be associated with the high prevalence of diabetic complications. | 17717877 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated LDL-cholesterol level predicts diabetes in centrally obese women but not men: relative roles of insulin resistance and central obesity. | 17721029 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Baseline clinical characteristics did not differ between groups except for more frequent hypertension and dyslipidemia in controls. | 17721626 |
| Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | In an attempt to understand how specific variants of different genes interact and intervene in the molecular and physiological mechanisms of disorders such as diabetes or insulin resistance, the search for gene-gene interactions is constantly growing. | 17727676 |
| Peripheral Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was found to independently affect occurrence of PVD (OR = 5.37, [95% CI 1.05-27.5], P = 0.05). | 17728365 |
| Dyslipidemias, Gastritis, Xanthomatosis | Deregulated Nutrient Sensing | To investigate the relationship among gastric xanthomatosis (GX), H pylori, dyslipidemia, and gastritis in Korea, a well-known H pylori endemic area. | 17729413 |
| Dyslipidemias, Infection caused by Helicobacter pylori, Gastritis, Atrophic | Deregulated Nutrient Sensing | Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but H pylori infection is not. | 17729413 |
| Hyperglycemia, Coronary heart disease, Cerebrovascular accident | Deregulated Nutrient Sensing | Our findings suggest that in women in the 60-79 y age range, insulin resistance, rather than insulin secretion or chronic hyperglycaemia, is a more important risk factor for coronary heart disease and stroke. | 17760500 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Thyroid Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of diabetes mellitus, dyslipidemia, hypertension, and thyroid disease is higher in older women, placing these women at increased risk of cardiovascular disease. | 17762424 |
| Chronic liver disease, Liver carcinoma | Deregulated Nutrient Sensing | Immunohistochemical expression of components of the Akt-mTORC1 pathway is associated with hepatocellular carcinoma in patients with chronic liver disease. | 17763954 |
| FAM126A gene | Deregulated Nutrient Sensing | Immunohistochemical evidence of activation of the Akt-mTORC1 pathway is associated with HCC. | 17763954 |
| Angina Pectoris, Dyslipidemias, Diabetes Mellitus, Heart failure, Hypertension, CTCAE | Deregulated Nutrient Sensing | Prevalence of diabetes, hypertension, dyslipidemia, and heart failure was similar among the anginal post-EECP anginal classes. | 17765644 |
| Dyslipidemias, Albuminuria | Deregulated Nutrient Sensing | Amelioration of albuminuria may be related to specific constellations of risk factors including race and dyslipidaemia. | 17766000 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | In the US population, apoB/apoAI ratio is significantly associated with insulin resistance in non-diabetic subjects, independently of the traditional risk factors, metabolic syndrome components, and inflammatory risk factors. | 17766927 |
| Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | [Correlation of dyslipidemia in patients with critical ischemia in Hospital Barao de Lucena - Recife/PE]. | 17768802 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | There are studies that confirm the association between dyslipidaemia and the genesis of atherosclerosis process in world literature. | 17768802 |
| Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | The goal of this study is to evaluate the incidence of the dyslipidaemia in patients with critical limb ischemia. | 17768802 |
| Renal Insufficiency, Inflammation | Deregulated Nutrient Sensing | Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. | 17785630 |
| Inflammation, Coronary heart disease | Deregulated Nutrient Sensing | This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation. | 17785630 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Treatment of hypertension and dyslipidemia or their combination among US managed-care patients. | 17786069 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes arises when insulin resistance-induced compensatory insulin secretion exhausts. | 17786204 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | Insulin resistance and/or beta-cell dysfunction result from the interaction of environmental factors (high-caloric diet and reduced physical activity) with a predisposing polygenic background. | 17786204 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | However, associations of these variations with insulin resistance and/or beta-cell dysfunction were not assessed. | 17786204 |
| EXT2 gene, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | In contrast, the other reported type 2 diabetes candidate SNPs within the EXT2 and LOC387761 loci did not associate with insulin resistance or beta-cell dysfunction, respectively. | 17786204 |
| Dyslipidemias, diabetic, Cardiovascular system | Deregulated Nutrient Sensing | Diabetic patients with accompanied (but often unnoticed) dyslipidemia are soft targets of cardiovascular deaths. | 17786383 |
| Dyslipidemias | Deregulated Nutrient Sensing | This investigation is an attempt to evaluate the diagnostic value of HbA(1c) in predicting diabetic dyslipidemia. | 17786383 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | The proportion of patients with hyperglycemia and dyslipidemia was not significantly different between the 2 groups. | 17803009 |
| Diabetes Mellitus, Non-Insulin-Dependent, atherosclerotic, Diabetes Mellitus | Deregulated Nutrient Sensing | The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes. | 17823381 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We may expect better management of oral health in diabetic patients with control of dyslipidemia in addition to blood glucose. | 17827833 |
| Non-alcoholic Fatty Liver Disease, Demographics Domain | Deregulated Nutrient Sensing | Obese patients with type 2 DM and insulin resistance develop more severe NAFLD and early sinusoidal fibrosclerosis. | 17846888 |
| Failure (biologic function) | Deregulated Nutrient Sensing | The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth. | 17848410 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Preterm birth is associated with postnatal growth failure, abdominal fat accumulation, insulin resistance, and hypertension, resembling increased glucocorticoid bioactivity. | 17848410 |
| Increased insulin level, Rabson-Mendenhall Syndrome, Hyperglycemia, Congenital Abnormality | Deregulated Nutrient Sensing | Rabson-Mendenhall syndrome is a rare genetic disorder characterized by severe insulin resistance, extreme hyperinsulinemia, postprandial hyperglycemia, growth retardation, and dysmorphisms. | 17849153 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors included hypertension (11 patients, 58%), smoking (14, 74%), diabetes (6, 30%), and dyslipidemia (12, 63%). | 17849948 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. | 17852419 |
| Dyslipidemias, Cerebrovascular accident, Coronary Artery Disease, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | These patients were older, had more rate of hypertension, dyslipidemia, coronary arterial disease, peripheral vascular disease and previous stroke than non-diabetic patients. | 17853961 |
| Inflammation | Deregulated Nutrient Sensing | C-reactive protein (CRP) was also measured since systemic inflammation is associated with insulin resistance in non-renal patients and inflammation is negatively modulated by ghrelin in experimental models. | 17854954 |
| Hyperglycemia | Deregulated Nutrient Sensing | Overdoses of calcium channel blocker agents result in hyperglycemia, primarily due to the blockade of pancreatic L-type calcium channels and insulin resistance on the cellular level. | 17855820 |
| Dyslipidemias | Deregulated Nutrient Sensing | On the basis of a high correlation, non-HDL-C (non-high-density lipoprotein cholesterol) and apoB (apolipoprotein B) have been suggested to be of equivalent value for clinical practice; however, the strength of this relationship has not been examined in detail in patients with dyslipidaemia. | 17868037 |
| Obesity | Deregulated Nutrient Sensing | Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. | 17870627 |
| Obesity | Deregulated Nutrient Sensing | We found that the individual polymorphisms were not associated with obesity, but the (-866G; rs659366)-(Del; 45bp)-(-55T; rs1800849) haplotype was significantly associated with obesity and its presence in the control group increased about nine times the insulin resistance risk. | 17870627 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | The interplay of insulin resistance and beta-cell dysfunction involves the development of type 2 diabetes in Chinese obeses. | 17873317 |
| Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Abdominal obesity, insulin resistance and hypertension: impact on left ventricular mass and function in women. | 17874012 |
| Hypertension, CTCAE, Electrocardiogram: left ventricle hypertrophy (finding), Obesity | Deregulated Nutrient Sensing | Our results indicate an association among hypertension, central obesity and left ventricular hypertrophy through increases in sympathetic activity and insulin resistance. | 17874012 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The retinol-binding protein 4 (RBP4) has been linked to the insulin resistance state in obesity and type 2 diabetes in animal studies. | 17875187 |
| Schizophrenia, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Bipolar Disorder | Deregulated Nutrient Sensing | Compared with schizophrenia patients, those with bipolar disorder were 19% more likely to have diabetes, 44% more likely to have coronary artery disease, and 18% more likely to have dyslipidemia, after adjustment. | 17878500 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between serum concentrations of saturated fatty acids and unsaturated fatty acids and the homeostasis model insulin resistance index in Japanese patients with type 2 diabetes mellitus. | 17878672 |
| Aortic Stiffness, diabetic | Deregulated Nutrient Sensing | We tested the hypothesis that tHcy correlates with aortic stiffness and insulin resistance in type 2 diabetic patients. | 17884450 |
| Diabetes Mellitus, Non-Insulin-Dependent, Aortic Stiffness | Deregulated Nutrient Sensing | In conclusion, our results indicate that the elevated level of tHcy in Japanese patients with type 2 diabetes mellitus is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV and the HOMA index are independent predictors of tHcy. | 17884450 |
| diabetic | Deregulated Nutrient Sensing | Diabetic rat studies suggest that skeletal muscle neuronal NOS (nNOS) micro protein expression may be reduced in human insulin resistance. | 17884453 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Both ectopic fat accumulation and changes of the amount of several adipocyte secreting proteins (adipokines) are thought to contribute to the development of insulin resistance associated with obesity and type 2 diabetes mellitus. | 17884455 |
| diabetic | Deregulated Nutrient Sensing | Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging. | 17884459 |
| Dyslipidemias, LYST wt Allele | Deregulated Nutrient Sensing | Whereas there was little association between USF1 genotype and metabolic or CVD traits in older adults from CHS, the USF1 low-risk dyslipidemia allele was associated with higher plasma C-reactive protein and interleukin (IL)-6 levels and with increased risk of mortality, particularly attributable to noncardiovascular causes. | 17885212 |
| Proteinuria, Dyslipidemias | Deregulated Nutrient Sensing | Proteinuria and dyslipidemia are nonimmune risk factors implicated in the deterioration of kidney function and associated with an increased risk of accelerated atherogenesis. | 17889157 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | The incidence of arterial hypertension and dyslipidemia was higher among ischemic heart disease recipients. | 17889185 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | Dyslipidemia is a common problem among heart transplant (HT) recipients; it is a frequent risk factor in these patients that is exacerbated by immunosuppressive drugs. | 17889199 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | Statins are effective drugs to treat dyslipidemia in HT recipients, but control is suboptimal in some patients. | 17889199 |
| TG gene | Deregulated Nutrient Sensing | Despite similar levels of total body fat, non-obese women had lower systolic blood pressure, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL)-cholesterol levels, insulin resistance indices, and RBP4 levels than non-obese women with visceral adiposity and had higher high-density lipoprotein-cholesterol levels. | 17890490 |
| TG gene | Deregulated Nutrient Sensing | Similarly, obese women without visceral adiposity had lower blood pressure, total cholesterol, TG levels, insulin resistance indices, and RBP4 levels than obese women with visceral adiposity. | 17890490 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The frequency of smoking, hypertension, and dyslipidemia was similar across groups. | 17894012 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Muscle strength is a marker of insulin resistance in patients with type 2 diabetes: a pilot study. | 17895577 |
| diabetic | Deregulated Nutrient Sensing | Our data suggest that lower-extremity muscle strength is independently associated with insulin resistance, which seems to be consistent with previous reports that resistance training improves glycemic control in type 2 diabetic patients. | 17895577 |
| Weight decreased | Deregulated Nutrient Sensing | Therapy with exenatide often results in weight loss, which further assists in decreasing insulin resistance. | 17896900 |
| Weight Gain, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | This weight gain led to insulin resistance and the development of type 2 diabetes; thus he had characteristics of both types 1 and 2 diabetes, or double diabetes. | 17896900 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Blood Glucose | Deregulated Nutrient Sensing | We sought to determine whether childbearing increases incidence of type 2 diabetes after accounting for preconception glycemia and gestational glucose intolerance. | 17898128 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution. | 17898946 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Decrease of insulin sensitivity and increase of insulin resistance are more obvious in hypertensive patients with genotype G of the 3 genes of SM constitution than in those of PI constitution. | 17898946 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Therefore, the difference in constitution might be one of the genetic characteristics for insulin resistance in hypertensive patients. | 17898946 |
| Breast Carcinoma | Deregulated Nutrient Sensing | It is unclear whether associations between sedentary time or physical activity and percent breast density are mediated through serum insulin levels or insulin resistance, factors also associated with physical activity and breast cancer risk. | 17903077 |
| Albuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impaired flow-mediated vasodilatation and insulin resistance in type 2 diabetic patients with albuminuria. | 17904244 |
| Diabetic Nephropathy, Endothelial dysfunction, Atherosclerosis, diabetic | Deregulated Nutrient Sensing | These results suggested that endothelial dysfunction which may be due to impaired NO production and insulin resistance underlie the association between diabetic nephropathy and atherosclerosis in diabetic patients. | 17904244 |
| Increased insulin level, Pancreatic carcinoma | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance have been proposed as underlying mechanisms for the increase in pancreatic cancer among long-standing diabetics and obese individuals. | 17905943 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study showed improvements in glycaemic control and dyslipidaemia in patients with type 2 diabetes poorly controlled with existing sulphonylurea therapy. | 17907109 |
| Microalbuminuria, Obesity, Visceral | Deregulated Nutrient Sensing | T2DM in young people is associated with marked visceral obesity, insulin resistance and microalbuminuria. | 17907114 |
| Acromegaly, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus develops in about 10% of acromegalic patients, usually secondary to insulin resistance caused by growth hormone excess. | 17908670 |
| Proteinuria, Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Exclusion criteria were absence of gross proteinuria, hypertension, dyslipidaemia or cardiovascular disease. | 17910281 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | A lower frequency of the PRM -352T allele of the STX1A gene was observed in overweight/obese subjects with impaired glucose regulation, particularly among individuals with combined glucose intolerance and overt diabetes. | 17912268 |
| Increased insulin level, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a rat model of type 2 diabetes mellitus. | 17913278 |
| Kidney Failure | Deregulated Nutrient Sensing | [Renal failure and insulin resistance: effect of the dialysis dose]. | 17915164 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | In patients with chronic renal failure, adapted dialysis, determined by the Kt/V index, correlated negatively with insulin resistance. | 17915164 |
| Gestational Diabetes | Deregulated Nutrient Sensing | [Heterogeneity of insulin resistance level in gestational diabetes mellitus. | 17915408 |
| Gestational Diabetes | Deregulated Nutrient Sensing | The evaluation of insulin resistance (IR) level in population of women with gestational diabetes(GDM) and its relation to treatment of GDM. | 17915408 |
| Gestational Diabetes | Deregulated Nutrient Sensing | Both, frequency of insulin therapy and daily insulin doses are associated with insulin resistance level at the GDM diagnosis. | 17915408 |
| TG gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We investigated the association between the serum butyrylcholinesterase (BChE) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) in Japanese patients with type 2 diabetes and non-diabetic subjects. | 17917325 |
| Acromegaly | Deregulated Nutrient Sensing | Insulin resistance index and fibrinogen levels were higher in patients with active acromegaly than patients and subjects in control groups. | 17917813 |
| Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and diabetes mellitus have recently been reported to affect cognition in patients with hepatitis C cirrhosis awaiting liver transplantation. | 17919230 |
| muscle mass | Deregulated Nutrient Sensing | Plasma ammonium ion levels were related to insulin resistance (r=0.42, P<0.001) and muscle mass (r=0.28, P=0.003). | 17919230 |
| helium | Deregulated Nutrient Sensing | Nutritional status and insulin resistance might be implicated in the pathogenesis of HE. | 17919230 |
| Communicable Diseases, Hepatitis C | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) infection causes insulin resistance. | 17919242 |
| Liver carcinoma, Hepatitis C | Deregulated Nutrient Sensing | Because increased insulin resistance is a risk factor for development of hepatocellular carcinoma and reduced long-term survival, insulin resistance is a therapeutic target in patients with HCV infection. | 17919242 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The study population comprised patients within the General Practice Research Database who began treatment for hypertension, dyslipidaemia or both between 1997 and 2001. | 17919356 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Nevertheless, there is a large unmet need for initiating and maintaining antihypertensive and lipid-lowering therapy in patients with hypertension and dyslipidaemia. | 17919356 |
| Dyslipidemias | Deregulated Nutrient Sensing | Eligible patients were those treated pharmacologically for dyslipidemia in the Cegedim Strategic Data general practice network. | 17919548 |
| Dyslipidemias, Diabetes Mellitus, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Patients with diabetes had a similarly increased risk of mixed dyslipidemias, whereas patients with a history of CHD did not. | 17919548 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with a greater number of nonlipid CV risk factors or with diabetes had a significantly increased risk of mixed dyslipidemias involving elevated TGs and/or low HDL-C in addition to elevated LDL-C. | 17919548 |
| Dyslipidemias | Deregulated Nutrient Sensing | The effect of pioglitazone as add-on therapy to metformin or sulphonylurea compared to a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia. | 17919894 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Diabetic dyslipidaemia contributes to the increased risk of cardiovascular disease in patients with Type 2 diabetes. | 17919894 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This paper examines the effectiveness of adding pioglitazone to metformin or a sulphonylurea (SU) compared with a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia in patients with Type 2 diabetes. | 17919894 |
| Cardiovascular morbidity, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The beneficial effects of pioglitazone on diabetic dyslipidaemia may help combat the increased cardiovascular morbidity and mortality observed in patients with Type 2 diabetes while providing stable glycaemic control. | 17919894 |
| Dyslipidemias | Deregulated Nutrient Sensing | High amounts of dietary fructose may contribute to dyslipidemia in adults, but there are few data in children. | 17921399 |
| Anemia | Deregulated Nutrient Sensing | Age- and body mass index-dependent relationship between correction of iron deficiency anemia and insulin resistance in non-diabetic premenopausal women. | 17921683 |
| Anemia | Deregulated Nutrient Sensing | No prospective studies have evaluated the effects of correction of iron deficiency anemia on insulin resistance in non-diabetic premenopausal women. | 17921683 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Blood pressure measurements, combined with a clinical questionnaire that included educational and socio-economic data, and standard blood samples for the detection of dyslipidemia and diabetes mellitus, were collected. | 17921815 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, dyslipidemia prevalence was significantly higher in the high-education group (27.1% as compared with 16.9% in the lowest-education group; P < 0.01). | 17923677 |
| Steatohepatitis, Metabolic Syndrome X | Deregulated Nutrient Sensing | The present study suggests that liver steatosis may be considered with some metabolic risk factors and particularly in the presence of insulin resistance and metabolic syndrome. | 17923799 |
| Dyslipidemias, Fatty degeneration, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Steatosis of the liver has a close association with metabolic conditions such as obesity, dyslipidemia and diabetes mellitus. | 17923799 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Among patients with diabetic dyslipidemia plus CHD, the use of statins increased almost threefold instead of a large reduction in the percentage with non-statin class. | 17924453 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | ROC curve analysis suggested WC cut-off points of 85 cm in men and 85 cm in women for the optimum detection of high blood pressure, diabetes and dyslipidaemia. | 17924868 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors included hypertension (93.7%), overweight/obesity (54.3%), dyslipidemia (44.9%), diabetes (42.1%), and smoking (24.3%). | 17925609 |
| Hypertensive (finding), Heart failure, Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance independently predicts heart failure and coronary disease, and has been related to thick left ventricular walls, mainly in studies of hypertensive samples not fully accounting for the influence of blood pressure. | 17932091 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Cerebral arterial pulsatility and insulin resistance in type 2 diabetic patients. | 17933415 |
| diabetic | Deregulated Nutrient Sensing | The aim of the present study was to investigate the association of insulin resistance with the pulsatility index (PI) of cerebral arteries in type 2 diabetic patients. | 17933415 |
| diabetic | Deregulated Nutrient Sensing | The PI was significantly higher in diabetic patients than in healthy controls (p<0.05) and also higher in patients with insulin resistance than that seen in insulin sensitive diabetic patients (p<0.05). | 17933415 |
| Cerebrovascular, Diabetes Mellitus | Deregulated Nutrient Sensing | PI could be a useful marker in the detection of diabetic cerebrovascular changes, and insulin resistance showed correlations with PI, but age and the duration of diabetes contributed independently to the variability in the PI. | 17933415 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | However, little is known about the dyslipidaemia associated with stroke in South Asians. | 17935546 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Using a case-control study, we investigated features of the dyslipidaemia in South Asian patients with stroke compared with South Asian subjects with no history of clinically detectable stroke. | 17935546 |
| Arterial Stiffness | Deregulated Nutrient Sensing | FMD was reduced in FDR, with or without insulin resistance, whereas arterial stiffness was significantly increased only in FDR with insulin resistance. | 17935958 |
| Glucose Intolerance (disease), Hypertriglyceridemia, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Biological testing confirmed glucose intolerance associated with a severe insulin resistance, hypertriglyceridemia and polycystic ovary syndrome. | 17936664 |
| Lipodystrophy, No metabolic abnormalities, Hypertriglyceridemia, Dermatomyositis, Childhood Type | Deregulated Nutrient Sensing | Lipodystrophy and metabolic abnormalities, primarily hypertriglyceridemia and insulin resistance, have been reported in juvenile dermatomyositis. | 17938031 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of dyslipidemia and age-adjusted hypertension was lower among Bedouins (5.8% vs. 18.2%, P < 0.01 and 17% vs. 21%, P < 0.001 respectively). | 17939626 |
| Increased insulin level, Sensorineural Hearing Loss (disorder), Blindness, Cone-Rod Dystrophies, Multiple System Atrophy, Obesity, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alstrom Syndrome is multisystemic, with cone-rod retinal dystrophy leading to juvenile blindness, sensorineural hearing loss, obesity, insulin resistance with hyperinsulinemia, and type 2 diabetes mellitus. | 17940554 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | There is therefore considerable need for cardiovascular risk-factor intervention, particularly for hypertension and obesity, as well as dyslipidaemia, along with tight metabolic control. | 17940668 |
| Hyperglycemia, TSC22D3 gene, Hyperinsulinism | Deregulated Nutrient Sensing | In particular, it is not clear whether short-term glucose-induced hyperglycaemia and hyperinsulinaemia as well as a glucocorticoid-induced increase in insulin resistance are reflected in appreciable alterations in serum visfatin levels in humans. | 17940983 |
| TSC22D3 gene | Deregulated Nutrient Sensing | Furthermore, the results of our study do not support the notion that glucocorticoid-induced insulin resistance is likely to be related to changes in serum concentrations of visfatin. | 17940983 |
| diabetic | Deregulated Nutrient Sensing | These data suggest that PPAR-g Pro12Ala may affect blood lipid levels and the abdominal fat storage of diabetic Ugyurs and Kazaks and may be associated with fat storage and insulin resistance in Hans. | 17941898 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Insulin resistance and depressive symptoms in young adult males: findings from Finnish military conscripts. | 17942838 |
| Bipolar Disorder | Deregulated Nutrient Sensing | To investigate whether the association between insulin resistance (IR) and depressive symptoms is present already in young adult males. | 17942838 |
| Obesity | Deregulated Nutrient Sensing | Contradictory results have been published regarding the influence of insulin resistance on these rheological parameters in obesity. | 17942983 |
| Hyperglycemia, Obesity, Visceral, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Key features are visceral obesity, dyslipidemia, hyperglycemia in the non-diabetic range, and arterial hypertension. | 17943407 |
| Hyperuricemia, Metabolic Syndrome X | Deregulated Nutrient Sensing | Subjects with hyperuricaemia but not with insulin resistance exhibited an increased risk to develop the metabolic syndrome. | 17945241 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and type 2 diabetes are associated with decreased expression of genes that regulate oxidative phosphorylation in skeletal muscle. | 17948130 |
| Diabetes Mellitus, Non-Insulin-Dependent, Gaucher Disease, Type 1 | Deregulated Nutrient Sensing | Overweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy. | 17950007 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK alpha2-subunit (PRKAA2) and risk of type 2 diabetes. | 17950019 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Additionally, the previously described association between the PRKAA2 (AMPK alpha2-subunit) haplotype and type 2 diabetes was tested for replication. | 17950019 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our findings suggest that genetic variants of LKB1-AMPK-TORC2 pathway components may exert a weak influence on the occurrence of type 2 diabetes in Japanese. | 17950019 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Adiponectin may play an important role in the regulation of body weight, insulin resistance, and cardiovascular disease. | 17950098 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Furthermore, these mice showed a basal hyperglycemia and glucose intolerance which disappeared with age. | 17950578 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | This observation suggests that the low HDL-C/low Apo A-I phenotype may result from a genetic defect directly affecting HDL metabolism, even in the context of a dyslipidemia which, like FCHL, is associated with low plasma HDL-C. | 17950741 |
| Adrenal Androgen Excess, Hyperandrogenism | Deregulated Nutrient Sensing | To ascertain an association between the a priori known insulin resistance caused by antipsychotic agents and divalproex and adrenal hyperandrogenism and to determine whether the associated hyperandrogenism is reversible with insulin sensitizers. | 17954415 |
| Adrenal Androgen Excess | Deregulated Nutrient Sensing | Insulin resistance caused by antipsychotic agents and divalproex is associated with adrenal hyperandrogenism. | 17954415 |
| Hypertension, CTCAE, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Cardiovascular risk factors, particularly hypertension and dyslipidaemia were prevalent in the studied patients with stroke. | 17957322 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity. | 17958881 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT). | 17959864 |
| Autoimmune Diseases, Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance can modulate progression to type 1 diabetes in individuals with ongoing islet autoimmunity. | 17959864 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | These data suggest that insulin resistance accelerates progression to type 1 diabetes in antibody-positive relatives in whom insulin secretion is markedly reduced but does not affect progression when insulin secretion is relatively well preserved. | 17959864 |
| Fat-free mass | Deregulated Nutrient Sensing | Improvement in HbA(1c) was related to decreased body fat (r = 0.484, P = 0.004) and improvement in insulin resistance was related to decreased body fat (r = 0.37, P = 0.03) and central adiposity (r = 0.38, P = 0.02), as well as increased fat-free mass (r = -0.46, P = 0.005). | 17965035 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cessation of life, Kidney Failure | Deregulated Nutrient Sensing | Primary PCI was associated positively with younger age, male sex, known dyslipidemia, and prior PCI (all P < .03), and negatively with diabetes, renal failure, prior myocardial infarction or bypass surgery, and higher predicted death by the Mediqual Atlas Outcomes score (all P < .01). | 17967609 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There were no significant differences in terms of diabetes mellitus, hypertension, dyslipidemia, plasma fibrinogen level, smoking, gender and family history of CAD with and without the FVL mutation in the patient group. | 17982311 |
| diabetic | Deregulated Nutrient Sensing | In the basal condition, in both healthy control individuals and diabetic patients, the whole blood viscosity at higher shear rate (450/s) was significantly correlated in a negative way with the index of insulin resistance (P < 0.05), and in a positive way with the haematocrit value (P < 0.05) and the platelet count (P < 0.01). | 17982315 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Current smoking was reported by 77.1% of patients, while a history of dyslipidemia, hypertension, or diabetes was found in 29.3%, 7.3%, and 4.9% of patients, respectively. | 17983529 |
| Dyslipidemias | Deregulated Nutrient Sensing | Compared with APOE*3/*3 homozygotes, patients with the APOE*4 allele had 1.3 times higher risk for CAD after ignoring dyslipidemia, but this risk was modified after adjusting for dyslipidemia. | 17985658 |
| ARCN1 gene, Primary malignant neoplasm, Demographics Domain, Presenile dementia, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Heart failure, Haiti | Deregulated Nutrient Sensing | Data were collected on sociodemographic endpoints, type of dementia, Barthel Index (BI), Lawton Index (LO), Mini-Mental State Examination (MMSE), Charlson Index, total number of drugs, history of high blood pressure (HT), diabetes (DM), dyslipidemia (DL), heart failure (HF), chronic obstructive pulmonary disease (COPD) and cancer. | 17988595 |
| Dyslipidemias, Psoriasis | Deregulated Nutrient Sensing | Dyslipidaemia was present in 50.9% of the patients with psoriasis, compared with 44.2% of the controls (p=0.015). | 17989888 |
| Overweight, Obesity | Deregulated Nutrient Sensing | Conditions such as overweight or obesity in which a degree of insulin resistance may be present may also be important. | 17991664 |
| Dyslipidemias | Deregulated Nutrient Sensing | A low plasma HDL-cholesterol concentration is a major characteristic of diabetic dyslipidemia. | 17991668 |
| Hyperlipidemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Fenofibrate, a fibric acid derivative, is used to treat diabetic dyslipidemia, hypertriglyceridemia, and combined hyperlipidemia alone or in combination with statins. | 17994463 |
| Inflammation, No metabolic abnormalities | Deregulated Nutrient Sensing | More metabolic abnormalities were associated with higher risk of inflammation, urinary albumin, and insulin resistance. | 17998025 |
| Atherosclerosis | Deregulated Nutrient Sensing | Low concentrations of endogenous androgens have been linked with insulin resistance and atherosclerosis. | 17998764 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin resistance, which is the main pathogenic factor for nonalcoholic fatty liver disease (NAFLD). | 18004085 |
| Weight decreased | Deregulated Nutrient Sensing | The results demonstrate that weight loss results in a decrease in normal ALT levels as well as insulin resistance. | 18004085 |
| Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Due to a vicious circle in which HCV favors insulin resistance and, alternatively, insulin resistance facilitates the persistence of HCV, HCV patients have often diabetes associated with liver cirrhosis. | 18018363 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is associated with a variety of atherosclerosis risk factors. | 18024935 |
| Obesity | Deregulated Nutrient Sensing | Visceral obesity increases risk of insulin resistance and type 2 diabetes. | 18025413 |
| Fatty Liver, Muscle hypertrophy | Deregulated Nutrient Sensing | It is characterized by a lack of adipose tissue throughout the body from birth, muscular hypertrophy, advanced bone age, fatty liver, and insulin resistance. | 18026908 |
| Steatohepatitis, Hepatitis B | Deregulated Nutrient Sensing | Association of chronic hepatitis B virus infection with insulin resistance and hepatic steatosis. | 18028349 |
| Virus Diseases, HIV | Deregulated Nutrient Sensing | Chronic viral infections such as human immunodeficiency virus and hepatitis C virus (HCV) may decrease tissue response to insulin, thereby causing insulin resistance. | 18028349 |
| Steatohepatitis | Deregulated Nutrient Sensing | In addition, insulin resistance is associated with hepatic steatosis. | 18028349 |
| Steatohepatitis | Deregulated Nutrient Sensing | The present study therefore aimed to investigate the association of chronic HBV infection with insulin resistance and hepatic steatosis. | 18028349 |
| Steatohepatitis | Deregulated Nutrient Sensing | Chronic HBV infection seems not to be associated with insulin resistance or hepatic steatosis in HBV carriers. | 18028349 |
| Oxygen saturation below reference range | Deregulated Nutrient Sensing | Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. | 18030445 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Animal and human data implicate hepatic desaturase activities in insulin resistance, obesity and dyslipidaemia. | 18030445 |
| Blood coagulation | Deregulated Nutrient Sensing | Fibrates produce additional actions such as reduction of inflammatory state, insulin resistance and activation of blood coagulation, along with stimulation of fibrinolysis. | 18030873 |
| Lipodystrophy, Aortic Valve Stenosis, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | A novel phenotypic expression associated with a new mutation in LMNA gene, characterized by partial lipodystrophy, insulin resistance, aortic stenosis and hypertrophic cardiomyopathy. | 18031308 |
| Aortic Valve Stenosis, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | The patient showed atypical fat distribution, insulin resistance, severe aortic stenosis and hypertrophic cardiomyopathy. | 18031308 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia and other cardiovascular risk factors in a Canadian First Nation pediatric population with type 2 diabetes mellitus. | 18036065 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The objectives of this study were to describe the prevalence of dyslipidemia in a population of youth with type 2 diabetes mellitus (T2DM) and to examine the relationship between the lipid parameters and other known cardiovascular risk factors. | 18036065 |
| Nonketotic Hyperglycinemia, Systolic hypertension, Obesity | Deregulated Nutrient Sensing | The proband was a 13.5-yr-old boy with marked non-ketotic hyperglycemia, obesity, systolic hypertension, and insulin resistance. | 18036134 |
| Hyperglycemia | Deregulated Nutrient Sensing | In utero hyperglycemia has been associated with insulin resistance (IR) in children; however, there are limited data in low-risk populations. | 18036135 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidaemia did not discriminate survival amongst South Asian patients. | 18036165 |
| Fatty Liver, Dyslipidemias, Glucose Intolerance (disease), Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | At the time of the baseline examinations, significant clinical associations were found between fatty liver and obesity (p<0.001), hypertension (p<0.001), dyslipidemia (p<0.001), and glucose intolerance (p<0.001). | 18037775 |
| Sensorineural Hearing Loss (disorder), square decimeter, Fatty Liver, Autosomal Recessive Disorder, Obesity, Retinitis Pigmentosa, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alstrom syndrome (AS) is an autosomal recessive disorder characterized by progressive pigmentary retinopathy, sensorineural hearing loss, fatty liver infiltration, obesity, insulin resistance and early-onset type 2 diabetes mellitus (DM2). | 18038714 |
| square decimeter | Deregulated Nutrient Sensing | Early onset of insulin resistance and DM2 are key components of this syndrome. | 18038714 |
| square decimeter | Deregulated Nutrient Sensing | We suggest that early initiation of combined therapy comprising a high dose of metformin plus rosiglitazone may be valuable in managing insulin resistance and DM2 in children with AS. | 18038714 |
| Failure (biologic function), Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Secondary treatment failure is often attributed to the development of obesity-related insulin resistance in combination with continued loss of beta-cell function. | 18039725 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance is frequently observed in patients with essential hypertension (EHT), and the renin-angiotensin system (RAS) has been demonstrated to modulate the status of insulin resistance. | 18041161 |
| Increased insulin level | Deregulated Nutrient Sensing | However, there was no significant relationship between PRA and indices of insulin resistance and hyperinsulinemia in patients with RVHT. | 18041161 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | The effects of exercise training on insulin resistance in patients with coronary artery disease. | 18043303 |
| Weight decreased | Deregulated Nutrient Sensing | Twelve weeks of moderate exercise training in the absence of weight loss did not result in significant change in insulin resistance in patients with CAD. | 18043303 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | We have used a randomised, matched-paired, double-blind, placebo-controlled experimental design to determine the capability of intravenous L-carnitine supplementation to modify insulin resistance and protein catabolism in non-diabetic patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis treatment. | 18045815 |
| Peripheral Vascular Diseases, Dyslipidemias, Microalbuminuria | Deregulated Nutrient Sensing | Odd ratios further increased, again as expected, with dyslipidemia (2.19; 95% CI, 1.54-3.12; P<.0001), peripheral arterial disease (2.61; 95% CI, 1.77-3.85; P<.0001), microalbuminuria (3.03; 95% CI, 1.91-4.82; P<.0001), and abnormal electrocardiographic findings (3.06; 1.68; 95% CI, 2.08-4.48; P<.0001). | 18046097 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. | 18046409 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes. | 18046409 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Men were more likely to smoke and have a history of heart disease and dyslipidemia. | 18048851 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Smoking was observed more in men (72 vs 26%) and systemic arterial hypertension in women (65 vs 48%), There were no differences in diabetes mellitus and dyslipidemia frequencies. | 18050935 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Incidence of childhood diabetes increased between 1994-2003, driven primarily by nT1, suggesting a role for behavioral and/or environmental determinants of insulin resistance. | 18051928 |
| Obesity | Deregulated Nutrient Sensing | Recently, local renin-angiotensin system of adipose tissue has been suggested as a possible contributor to the development of insulin resistance in patients with obesity. | 18052686 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | To avoid an increase in insulin resistance, it seems important to attend to radically non-vital teeth as well as any other dental inflammation in diabetic patients. | 18052712 |
| Dyslipidemias | Deregulated Nutrient Sensing | We also modeled the effect of treating obesity-related increases in blood pressure and dyslipidemia. | 18057339 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | For dyslipidaemia and hyperuricaemia, the corresponding figures were 331 (54%) and 191 (31%). | 18057428 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | In total, 264 (43%) patients were newly diagnosed as having dysglycaemia, dyslipidaemia, or hyperuricaemia. | 18057428 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Androgen excess is associated with insulin resistance and the development of diabetes in African American women. | 18059208 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This prospective study demonstrates that relative androgen excess is associated with insulin resistance and increases the risk for development of diabetes in premenopausal African American women. | 18059208 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. | 18060751 |
| Increased insulin level | Deregulated Nutrient Sensing | We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. | 18060751 |
| Increased insulin level | Deregulated Nutrient Sensing | Subjects with isolated insulin resistance had also higher BP whereas subjects with isolated hyperinsulinemia had lower BP. | 18060751 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance might contribute with distinct and independent mechanisms to the development of several metabolic and hemodynamic disorders often clustering in the same individual. | 18060751 |
| Increased insulin level, Hyperuricemia, Hypertriglyceridemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | In particular, hypertriglyceridemia, low HDL-cholesterol and hyperuricemia seem to be related to both hyperinsulinemia and insulin resistance, whereas hypertension seems to be related only to insulin resistance. | 18060751 |
| Inflammation | Deregulated Nutrient Sensing | One possible mediator may be inflammation, but longitudinal data relating FA composition to inflammation taking insulin resistance into account are limited. | 18062827 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study. | 18063093 |
| Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Depression is associated with an increased risk of incident diabetes, and insulin resistance is thought to be the underlying link between them. | 18063093 |
| Kidney Diseases | Deregulated Nutrient Sensing | Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients. | 18065581 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance has been noted in patients with chronic kidney disease (CKD). | 18065581 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The determinants of insulin resistance have not been well-studied in CKD patients. | 18065581 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The objective of this study was to examine the degree and determinants of insulin resistance in persons without diabetes but with stage 3-4 CKD. | 18065581 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Whereas insulin resistance is highly prevalent in stage 3-4 CKD, the primary determinant of insulin resistance in this population is BMI, specifically, fat mass. | 18065581 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The following prevalences were found: hypertension: 14.7%; diabetes: 2.3%; dyslipidemia: 18.7%; obesity: 15.6%; increased waist circumference: 24.1%; and smoking: 15.6%. | 18066452 |
| Dyslipidemias | Deregulated Nutrient Sensing | Anacetrapib produced dose-dependent lipid-altering effects with peak lipid-altering effects of 129% (mean 51.1 [SD 3.8]-114.9 [7.9] mg/dL) increase in HDL-C and a 38% (138.2 [11.4]-77.6 [7.9] mg/dL) decrease in LDL-C in patients with dyslipidaemia. | 18068514 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Our findings suggest that severe insulin resistance of Mc4rKO fed a HFD, as reported in other models of obesity such as leptin-deficient (Lep(ob)/Lep(ob)) and KK-A(y) mice, is linked to reduced serum adiponectin and high levels of inflammation in adipose tissue. | 18070757 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Functional studies suggest that the nonsynonymous K121Q polymorphism in the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) may confer susceptibility to insulin resistance; genetic evidence on its effect on type 2 diabetes, however, has been conflicting. | 18071025 |
| Weight decreased | Deregulated Nutrient Sensing | The amelioration of insulin resistance in this group could not be totally explained by weight loss. | 18071341 |
| Lipodystrophy, Hyperlipidemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Partial lipodystrophy (PL) is most commonly characterized by loss of subcutaneous fat in the extremities with preservation of truncal fat and is associated with insulin resistance, diabetes and hyperlipidaemia. | 18076675 |
| Chronic Kidney Diseases, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | The prevalence of obesity, hyperuricemia, chronic kidney disease (CKD), insulin resistance and MS was 42.2, 31.2, 30.9, 36.0 and 47.5%, respectively. | 18082342 |
| Chronic Kidney Diseases, Hyperuricemia | Deregulated Nutrient Sensing | Male gender, CKD, BMI>23 kg/m(2) and insulin resistance were all independent risk factor for hyperuricemia with the covariate of age. | 18082342 |
| Chronic Kidney Diseases, Hyperuricemia | Deregulated Nutrient Sensing | When age and BMI were controlled, females had significantly higher prevalence of CKD and insulin resistance, but less hyperuricemia than males (P all<0.05). | 18082342 |
| Hyperuricemia | Deregulated Nutrient Sensing | Adjusted for age, BMI and GFR, hyperuricemia and MS were both independent risk factors for insulin resistance in females (P=0.006, <0.001, respectively). | 18082342 |
| Hyperuricemia | Deregulated Nutrient Sensing | In males, MS remained significantly associated with insulin resistance (P=0.002) but not hyperuricemia (P=0.813). | 18082342 |
| Hyperuricemia | Deregulated Nutrient Sensing | Studies related to insulin resistance may be needed when hyperuricemia was identified in older women. | 18082342 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | [Screening for dyslipidemia based on family history combined with obesity in children]. | 18087547 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | To explore the significance of family history combined with obesity in screening dyslipidemia in children. | 18087547 |
| Hyperlipidemia, Hypercholesterolemia, Dyslipidemias, Hypertriglyceridemia | Deregulated Nutrient Sensing | The percentages of dyslipidemia in non-obese children without family history, non-obese children with family history, obese children without family history, and obese children with family history were as follows: hyperlipidemia: 7.9%, 9.6%, 30.1% and 31.5%, respectively; hypercholesterolemia: 0.9%, 1.5%, 3.3% and 2.9%, respectively; hypertriglyceridemia: 7.1%, 8.6%, 29.2% and 31.3% respectively. | 18087547 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Family history combined with obesity is important in identifying dyslipidemia in children. | 18087547 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | A missense mutation of the human ADRB3 gene replacing tryptophan with arginine at codon 64 (Trp64Arg) has been related to obesity, insulin resistance, earlier onset of noninsulin-dependent diabetes mellitus and hypertension. | 18088254 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). | 18089891 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Adjusted for age, sex, family history of diabetes, race/ethnicity, income and education, insulin resistance was reduced by 17% (95% confidence interval = -31% to -1%) for an increase from the 10th to 90th percentiles of resources. | 18091002 |
| Microalbuminuria, Obesity | Deregulated Nutrient Sensing | UAE of 10-29 mg/day (hyperalbuminuria), below the conventionally used limit to define microalbuminuria, is already associated with a more adverse cardiovascular risk profile, and is exquisitely sensitive to interventions that reduce obesity, BP, and insulin resistance. | 18091752 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Evidence shows that even a slight reduction in body mass may improve carbohydrate tolerance, lipid profile and insulin resistance, reduce insulin levels and finally delay or reduce risk of diabetes mellitus. | 18159849 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance accompanies hyperinsulinemia, a major indicator of insulin resistance. | 18159849 |
| Histiocytosis, Langerhans-Cell, Hypopituitarism | Deregulated Nutrient Sensing | However, the insulin resistance index GIR was decreased in patients with LCH without anterior pituitary deficiency compared to controls (P = 0.033). | 18160417 |
| Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | In vivo elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor. | 18160637 |
| Fibrosis Assessment, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. | 18164296 |
| Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Hepatitis C | Deregulated Nutrient Sensing | Our study was designed to test the association between insulin resistance (IR) and hepatitis C virus (HCV) genotypes, serum HCV RNA level and liver fibrosis stage in a large prospective cohort of chronic hepatitis C (CHC) patients. | 18164296 |
| Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | This study investigated the relationship between oxidative stress, insulin resistance, steatosis and fibrosis in CHC. | 18164507 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | IgG against malondialdehyde-albumin adducts and HOMA-IR were measured as markers of oxidative stress and insulin resistance, respectively, in 107 consecutive CHC patients. | 18164507 |
| Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance and steatosis were evident in 80% and 70% of the patients, respectively. | 18164507 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | In patients infected by HCV genotype non-3, oxidative stress and insulin resistance contribute to steatosis, which in turn exacerbates both insulin resistance and oxidative stress and accelerates the progression of fibrosis. | 18164507 |
| Hyperlipidemia | Deregulated Nutrient Sensing | Insulin resistance and oxidative stress in familial combined hyperlipidemia. | 18164710 |
| Hyperlipidemia, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. | 18164710 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Calpain-10 (CAPN10) has been identified as a susceptibility gene in type 2 diabetes mellitus (T2DM) and insulin resistance. | 18167206 |
| Increased insulin level, Saint Lucia, Liver Cirrhosis | Deregulated Nutrient Sensing | Liver cirrhosis (LC) is characterized by an elevated number of circulating proinflammatory cytokines, hyperinsulinemia and insulin resistance. | 18171344 |
| Obesity, Abdominal, Colonic adenomas | Deregulated Nutrient Sensing | [Abdominal obesity, insulin resistance, and the risk of colonic adenoma]. | 18172342 |
| Increased insulin level, Carcinogenesis, Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity and hyperinsulinemia or insulin resistance are of interest in connection with colon carcinogenesis. | 18172342 |
| Colonic adenomas | Deregulated Nutrient Sensing | However, insulin resistance was not related to colonic adenoma. | 18172342 |
| Hypertensive disease, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Single-pill amlodipine/atorvastatin therapy was well tolerated and effectively targeted HTN and dyslipidemia in this population of African Americans who were at risk of cardiovascular disease. | 18174006 |
| Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. | 18174544 |
| ARCN1 gene | Deregulated Nutrient Sensing | To determine the expression of SIRT1 in lungs of smokers and patients with COPD, and to elucidate the regulation of SIRT1 in response to cigarette smoke in macrophages, and its impact on nuclear factor (NF)-kappaB regulation. | 18174544 |
| ARCN1 gene | Deregulated Nutrient Sensing | Peripheral lungs of smokers and patients with COPD showed decreased levels of nuclear SIRT1, as compared with nonsmokers, associated with its post-translational modifications (formation of nitrotyrosine and aldehyde carbonyl adducts). | 18174544 |
| ARCN1 gene | Deregulated Nutrient Sensing | SIRT1 levels were reduced in macrophages and lungs of smokers and patients with COPD due to its post-translational modifications by cigarette smoke-derived reactive components, leading to increased acetylation of RelA/p65. | 18174544 |
| ARCN1 gene | Deregulated Nutrient Sensing | Thus, SIRT1 plays a pivotal role in regulation of NF-kappaB-dependent proinflammatory mediators in lungs of smokers and patients with COPD. | 18174544 |
| Endothelial dysfunction, diabetic | Deregulated Nutrient Sensing | Advanced endothelial dysfunction in diabetic patients with multiple risk factors; importance of insulin resistance. | 18174660 |
| diabetic | Deregulated Nutrient Sensing | The present study was undertaken to determine whether the accumulation of cardiovascular risk factors and insulin resistance are associated with endothelial function in diabetic patients. | 18174660 |
| Endothelial dysfunction, diabetic | Deregulated Nutrient Sensing | The present results suggest that the accumulation of cardiovascular risk factors is associated with endothelial dysfunction in diabetic patients, and that insulin resistance as well as high blood pressure could play a pathogenic role in the development of endothelial dysfunction. | 18174660 |
| Carotid Intima-Media Thickness, Dyslipidemias, macroangiopathy, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | 101 patients with type 2 diabetes without macroangiopathy stratified by the number of cardiovascular risk factors (dyslipidemia, hypertension, obesity) and 9 normal control subjects were studied for vascular endothelial functions by measuring flow-mediated vasodilation (FMD) using a high-resolution ultrasound method, brachial-ankle pulse wave velocity (baPWV), carotid intima-media thickness (IMT), and the ankle-brachial index (ABI). | 18174660 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is a risk factor for cardiovascular disease. | 18174771 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | We also evaluated the presence of the insulin-resistance hepatic iron overload and of non-alcoholic fatty liver disease. | 18177470 |
| Anxiety, CTCAE 3.0, Atherosclerosis | Deregulated Nutrient Sensing | Associations between trait anxiety, insulin resistance, and atherosclerosis in the elderly: a pilot cross-sectional study. | 18178323 |
| Atherosclerotic lesion | Deregulated Nutrient Sensing | Recent evidence is accumulating to show that insulin resistance (IR) plays a central role in determining the clinical manifestations of established atherosclerotic lesions. | 18178323 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. | 18179892 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | In vitro gene expression analysis in human coronary endothelial cells revealed that resistin induced fatty acid binding protein, a key molecule of insulin resistance, diabetes, and atherosclerosis. | 18180399 |
| Decreased HDL cholesterol concentration, Diastolic hypertension | Deregulated Nutrient Sensing | In longitudinal analyses adjusted for CVD risk factors and leptin at the previous menopausal stage, aging, education, smoking and physical activity, greater increases in leptin over the menopause transition were associated with greater decreases in high-density lipoprotein cholesterol (HDL-c) and greater increases in diastolic blood pressure, glucose, insulin and insulin resistance (all P < 0.05). | 18180784 |
| Increase in blood pressure | Deregulated Nutrient Sensing | Larger decreases in adiponectin over the menopause transition were associated with greater increases in systolic blood pressure, insulin and insulin resistance and with greater decreases in HDL-c. | 18180784 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Common cardiovascular risk factors were: arterial hypertension (66.7%), dyslipidemia (58.9%), diabetes (42.9%), and smoking (27.4%). | 18187280 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity is a major risk factor for insulin resistance and type 2 diabetes mellitus (T2DM). | 18188531 |
| Alzheimers Disease", Data types - Address, Diabetes Mellitus, Apolipoprotein E4, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is a risk factor for late-onset Alzheimer's disease (AD), and studies suggest that pathogenic effects of diabetes and insulin resistance may be associated with non-APOE4 AD. | 18189240 |
| Diabetes Mellitus, Data types - Address, Overweight, Obesity | Deregulated Nutrient Sensing | We also examined for interactions involving weight status as overweight and obesity are independent risk factors for insulin resistance, diabetes and AD. | 18189240 |
| Obesity | Deregulated Nutrient Sensing | The inverse correlation between adiponectin and insulin resistance may manifest in the later phase of obesity development. | 18191043 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Individuals with two hypertensive parents had high insulin, insulin resistance and low-density lipoprotein cholesterol. | 18192842 |
| palladium, Pancreatic carcinoma | Deregulated Nutrient Sensing | Before the PD, the insulin curve suggested the presence of insulin resistance in pancreatic cancer patients, which was not observed after the operation. | 18192877 |
| Hyperinsulinism | Deregulated Nutrient Sensing | We report that rs2918419 was linked with hyperinsulinaemia and insulin resistance in men. | 18194492 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Although elevated levels of serum triglycerides are well documented with use of this drug, to the best of our knowledge this is the first report of a patient in whom polycystic ovary syndrome, a condition known to be associated with insulin resistance, manifested during isotretinoin therapy. | 18194936 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The main outcome measures were prevalence of dyslipidemia, hyperglycemia, and hypertension; self-reported health status; and health care expenditures. | 18195001 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity in older women: potential role for disrupted fatty acid reesterification in insulin resistance. | 18198225 |
| Nonesterified Fatty Acids Measurement, Obesity, Abdominal | Deregulated Nutrient Sensing | Our objectives were to examine the role of abdominal obesity on adipose tissue, hepatic, and peripheral insulin resistance in aging, and to examine impaired free fatty acid metabolism as a mechanism in these relations. | 18198225 |
| Hypertriglyceridemia, Neoplasms | Deregulated Nutrient Sensing | It was suggested that hypertriglyceridemia was brought about by early-onset insulin resistance in fat tissue prior to development of tumors. | 18198613 |
| Amyotrophic Lateral Sclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. | 18199832 |
| Neoplasms | Deregulated Nutrient Sensing | Mammalian Sir2 (SIRT1) has also been found to regulate premature cellular senescence induced by the tumor suppressors PML and p53. | 18203716 |
| Carcinogenesis | Deregulated Nutrient Sensing | The sirtuins and silent information regulator 1 (SIRT1) in particular, are known to play a role in the response to DNA damage, metabolism, longevity and carcinogenesis. | 18204789 |
| levothyroxine | Deregulated Nutrient Sensing | In this context, we identified L-thyroxin, insulin and sodium nitroprusside to be potent activators of human SIRT1 expression. | 18204789 |
| levothyroxine | Deregulated Nutrient Sensing | In addition, treatment of PBMCs with sodium nitroprusside was associated with a significant cellular lifespan extension, while L-thyroxin and insulin were unable to prolong lifespan, suggesting that isolated upregulation of SIRT1 is in fact insufficient to promote longevity. | 18204789 |
| Obesity | Deregulated Nutrient Sensing | To measure plasma ghrelin levels in children and adolescents, analyze the associated factors, and investigate the role of ghrelin in obesity, insulin resistance and reproductive physiology. | 18205273 |
| Hypertension, CTCAE, Stricture of artery, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, dyslipidemia and diabetes were risk factors for the development of intracranial arterial stenosis. | 18206033 |
| Refractory anemias, Dyslipidemias, Comorbidity, Angina Pectoris | Deregulated Nutrient Sensing | A comorbidity of dyslipidemia, prior angina, percutaneous coronary intervention (PCI) within 6 months was more common in patients with RA, P < 0.05. | 18208658 |
| Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Degenerative polyarthritis, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | 172 sedentary older adults with overweight or obesity, type 2 diabetes, hypertension, dyslipidemia, or osteoarthritis were enrolled in a randomized controlled trial with a 3-month follow-up. | 18209255 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Patients with Stage D HF are frequently males with dyslipidemia and coronary artery disease. | 18215606 |
| GDC Comorbidity Terminology, Dyslipidemias, Arthritis, Psoriatic, Hypertension, CTCAE | Deregulated Nutrient Sensing | Preexisting comorbid conditions included psoriatic arthropathy (13%), dyslipidemia (14.1%) and hypertension (20.2%). | 18216476 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The relationship between dyslipidaemia and cardiovascular disease is well documented. | 18218195 |
| Lupus Erythematosus | Deregulated Nutrient Sensing | Type B insulin resistance syndrome induced by increased activity of systemic lupus erythematosus in a hemodialysis patient. | 18218307 |
| Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | The presented patient developed a Type B insulin resistance syndrome induced by increased activity of SLE after she had been treated with hemodialysis for 5 years. | 18218307 |
| Hypoglycemia, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Type B insulin resistance syndrome must be considered in the differential diagnosis of hypoglycemia in SLE patients on dialysis. | 18218307 |
| Proteinuria, Kidney Failure | Deregulated Nutrient Sensing | Impact of age, body mass index, insulin resistance and proteinuria on the kidney function in obese patients with Type 2 diabetes and renal insufficiency. | 18218312 |
| Dyslipidemias | Deregulated Nutrient Sensing | Complications of dyslipidemia increase the risk, but direct evidence is limited, so a cohort prospective study (Japan-CDM) was conducted. | 18219157 |
| Hypercholesterolemia, Arteriosclerosis, Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | Osteoporosis has been linked with arteriosclerotic vascular diseases, suggesting that hypercholesterolemia or dyslipidemia may be a common pathogenetic factor underlying these diseases. | 18219179 |
| Hypercholesterolemia, Dyslipidemias, Fracture | Deregulated Nutrient Sensing | These results indicate increased bone turnover in hypercholesterolemic or dyslipidemic patients regardless of gender, and suggest the importance of treating hypercholesterolemia or dyslipidemia in order to prevent not only arteriosclerotic complications but also osteoporotic bone loss and subsequent fractures. | 18219179 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To establish the frequency of dyslipidemia in obese Israeli children and adolescents and its association with other cardiovascular disease (CVD) risk factors. | 18219218 |
| Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | [Effects of a superselective beta1-adrenoblocker nebivolol on the course of coronary heart disease and insulin resistance in patients with diabetes mellitus type 2 after coronary artery bypass grafting]. | 18220029 |
| Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To study safety and effects of nebivolol on the course of coronary heart disease (CHD) and insulin resistance (IR) in patients with diabetes mellitus type 2 (DM-2) after coronary artery bypass grafting. | 18220029 |
| Dyslipidemias | Deregulated Nutrient Sensing | This lowered the risk of effects of diabetic atherogenic dyslipidemia. | 18220029 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is prevalent in children with type 1 diabetes mellitus (T1DM), with an association between elevated hemoglobin A1c (HbA1c), serum lipid levels, and oxidative stress. | 18221422 |
| Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Insulin resistance fell once normal thyroid function was restored and helped to attenuate further beta-cell destruction when beta-cell mass was relatively well preserved. | 18221436 |
| Weight decreased | Deregulated Nutrient Sensing | Metformin, without weight loss or increased physical activity, resulted in restoration of menstrual cycle, reduction in serum T, and improvement in insulin resistance (IR). | 18222436 |
| Weight Gain | Deregulated Nutrient Sensing | High birth weight and early postnatal weight gain protect obese children and adolescents from truncal adiposity and insulin resistance: metabolically healthy but obese subjects? | 18223033 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Low birth weight (LBW), no early catch-up weight, and subsequent fat accumulation have been associated with increased risks of insulin resistance from childhood onward and later cardiovascular disease. | 18223033 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | After adjusting for these variables, multivariate analysis showed weight increase, waist-to-hip ratio and the indices of insulin resistance and beta-cell function were significantly associated with the risk for type 2 diabetes. | 18226046 |
| Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | It has been demonstrated that parents and brothers of PCOS women exhibit insulin resistance and related metabolic defects. | 18230657 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | In addition, insulin resistance became evident as the subjects got older, which may place them at risk for the development of type 2 diabetes and cardiovascular disease. | 18230657 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Visfatin and lipocalin-2 are novel adipokines associated with insulin resistance (IR) and obesity-related metabolic disorders. | 18230827 |
| Fatty Liver | Deregulated Nutrient Sensing | Are saturated fatty acids and insulin resistance associated with fatty liver in obese children? | 18234396 |
| Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance (IR) play an important role in pathogenesis of FL. | 18234396 |
| Inflammation, Endothelial dysfunction | Deregulated Nutrient Sensing | Both biomarkers of endothelial dysfunction correlated significantly with markers of inflammation (interleukin-6 [IL-6] and C-reactive protein [CRP]), hepatic function (gamma-glutamyl transferase [GGT]), and insulin resistance, with t-PA showing stronger associations with adiposity, hepatic function, and insulin resistance than vWF. | 18235054 |
| Hepatitis C | Deregulated Nutrient Sensing | Prospective study of liver transplant recipients with HCV infection: evidence for a causal relationship between HCV and insulin resistance. | 18236394 |
| Communicable Diseases, Hepatitis C | Deregulated Nutrient Sensing | An association between hepatitis C virus (HCV) infection and insulin resistance (IR) has been recently reported. | 18236394 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Genotyping for beta(1)Ser49Gly polymorphism in type II diabetic patients may have clinical benefit to predict obesity, thereby contributing to the prevention of insulin resistance. | 18239290 |
| Smoking Status, Obesity, Visceral, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Analysis of covariance showed that interaction between BMI and visceral obesity (f=7.202, p=0.007) was significantly associated with IMT, in addition to age, visceral obesity, smoking status, hypertension, dyslipidemia and uric acid. | 18239322 |
| Diastolic dysfunction, Hypertensive (finding) | Deregulated Nutrient Sensing | Diastolic dysfunction is associated with insulin resistance, but not with aldosterone level in normotensive offspring of hypertensive families. | 18239385 |
| Obesity | Deregulated Nutrient Sensing | Resistin is thought to be involved in the development of obesity and insulin resistance. | 18239575 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Heart transplant recipients often suffer from obesity, dyslipidemia, and hypertension thought to be related to triple-drug immunosuppression and poor adherence to diet and exercise. | 18240698 |
| Hepatobiliary Disorder, Dyslipidemias | Deregulated Nutrient Sensing | Therefore variations in the plasma lipid profile due to primary (genetic) or secondary (environmental) dyslipidemia could affect the development of liver disease. | 18241317 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR), or low insulin sensitivity, is a major risk factor in the pathogenesis of type 2 diabetes and cardiovascular disease. | 18242418 |
| Obesity | Deregulated Nutrient Sensing | The anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra) is the most highly elevated known cytokine in human obesity, and its serum levels are strongly associated with the degree of insulin resistance in non-diabetic patients. | 18243027 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The increased load on the pancreas from insulin resistance induced by chronically short sleep durations can, over time, compromise beta-cell function and lead to type 2 diabetes. | 18246976 |
| ARCN1 gene, Primary malignant neoplasm, Demographics Domain, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Heart failure | Deregulated Nutrient Sensing | Data were collected on sociodemographic variables, Barthel index, Lawton index), Minimental State Examination, total number of drugs, history of high blood pressure (HBP), diabetes mellitus (DM), dyslipidemia (DL), heart failure (HF), chronic obstructive pulmonary disease (COPD) and cancer. | 18247277 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Staged diabetes management according to individual patient insulin resistance and beta-cell function ameliorates glycaemic control in type 2 diabetes mellitus. | 18248646 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The new SDM strategy, based on individual data on insulin resistance and insulin secretion, may provide valuable clinical benefits in non-obese Korean patients with type 2 diabetes. | 18248646 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Among MS-positive subjects, insulin resistance ranged from 94.8% (EGIR) to 49.2% (IDF), whereas type 2 diabetes mellitus (excluded by EGIR and AACE criteria) rated 59.9% by World Health Organization and 22% to 24% by ATP III, IDF, or American Heart Association/National Heart, Lung, and Blood Institute. | 18249207 |
| Glucose Intolerance (disease), Hyperuricemia | Deregulated Nutrient Sensing | Both NCEP- and IDF-MS were associated with glucose intolerance and hyperuricemia. | 18250613 |
| Obesity | Deregulated Nutrient Sensing | [Study on the relationships of childhood obesity and the duration of sleep as well as insulin resistance]. | 18251279 |
| Dyslipidemias, Mental disorders, Diabetes Mellitus | Deregulated Nutrient Sensing | Increased risk of diabetes and dyslipidemia is associated with major mental illness and antipsychotic drug use. | 18251625 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our findings provide a mechanistic explanation for the involvement of these genetic variations in the development of insulin resistance and type 2 diabetes. | 18252792 |
| Inflammation, ETV3 wt Allele | Deregulated Nutrient Sensing | Our findings suggest that higher circulating adiponectin levels may mitigate against adipose-related inflammation, insulin resistance and MetS as much in lean as obese persons. | 18253163 |
| Deficiency of butyryl-CoA dehydrogenase, Hypertensive (finding), Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | SCAD was significantly more prevalent in patients aged > or = 60 (13.2%, vs 6.25%; p < .001), in symptomatic patients (16.45% vs 6.32%; p < .001), in diabetics (15.96% vs 7.39%; p < .001), in patients with ischemic heart disease (17.65% vs 7.22%; p < .001), in hypertensive patients (12% vs 7.54%; p = .025), and in patients with dyslipidemia (12.53% vs 6.56%; p < .025). | 18258161 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Glucose metabolism, insulin resistance, and renal pathology in non-diabetic chronic kidney disease. | 18259103 |
| Atherosclerosis | Deregulated Nutrient Sensing | The relation between insulin resistance and atherosclerosis is widely recognized, but it remains unknown whether glucose metabolism/insulin resistance is related to renal pathology in humans. | 18259103 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Although precise mechanisms remain unknown, glucose metabolism/insulin resistance seem to play pathogenic roles in formation and progression of renal pathological changes, especially tubulointerstitial and vascular lesions, in non-diabetic CKD. | 18259103 |
| Dyslipidemias | Deregulated Nutrient Sensing | More than 80% of symptomatic postmenopausal women had atherogenic dyslipidemias. | 18260873 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The latter stands as the basis upon which diabetes, hypertension, and atherogenic dyslipidemia tend to build up. | 18264836 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We reveal a previously unrecognized role for DGKdelta in contributing to hyperglycemia-induced peripheral insulin resistance and thereby exacerbating the severity of type 2 diabetes. | 18267070 |
| Pliability | Deregulated Nutrient Sensing | DGKdelta deficiency causes peripheral insulin resistance and metabolic inflexibility. | 18267070 |
| Obesity, Coronary heart disease | Deregulated Nutrient Sensing | The influence of obesity and consequent insulin resistance on coronary risk factors in medically treated patients with coronary disease. | 18268512 |
| Hyperlipidemia, Congenital Abnormality, Coronary heart disease, Obesity, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity promotes the development and progression of coronary heart disease (CHD), in part, through its association with hyperlipidemia, hypertension, clotting abnormalities and insulin resistance. | 18268512 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance is a hallmark of type 2 diabetes and commonly observed in other energy-stressed settings such as obesity, starvation, inactivity and ageing. | 18269172 |
| Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | In the Insulin Resistance and Atherosclerosis Study (IRAS), we have previously shown a protective effect of plasma alpha-tocopherol concentration against diabetes incidence among persons not taking vitamin E supplements. | 18269637 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, daytime sleepiness, Fatigue | Deregulated Nutrient Sensing | Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. | 18270241 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, Daytime somnolence, Fatigue | Deregulated Nutrient Sensing | Fatigue in NAFLD appears to be unrelated to either severity of underlying liver disease or insulin resistance, but is associated with significant daytime somnolence. | 18270241 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | Hyperandrogenia and insulin resistance are heritable family traits, likely to cluster in children of polycystic ovary syndrome (PCOS) mothers. | 18270257 |
| Atherosclerosis | Deregulated Nutrient Sensing | A slight but significant increase in prolonged insulin secretion, which is associated with the early stage of insulin resistance, in subjects with NGT, may play an important role in the pathogenesis of atherosclerosis. | 18270458 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A low plasma HDL-C level is characteristic of atherogenic dyslipidemia in patients with type 2 diabetes. | 18270459 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Identifying metabolic syndrome patients may direct therapy focusing on treatment of insulin resistance by reducing weight and increasing physical activity. | 18273039 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance (IR) is now considered to be a risk factor for coronary arterial atherosclerosis and is likely to be involved in a limited endothelium-dependent vasodilatory function in peripheral circulation. | 18273540 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The baseline prevalence of high blood pressure and dyslipidemia is higher in diabetic patients (70.4% vs. 54% and 73.2% vs. 50.6%, respectively). | 18275764 |
| Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Several PCOS women present abdominal adiposity (visceral fat) with a level of peripheral insulin resistance (IR), similar to that present in women with type 2 diabetes, in association with an increased incidence of impaired glucose tolerance. | 18277351 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Association of hypertensive diastolic blood pressure with dyslipidemia during exercise in apparently healthy subjects. | 18277829 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Concurrent hypertension and dyslipidaemia in THIN increased from 5.5% (1.1%) in 1998 to 13.5% (4.5%) in 2003 and 17.4% (7.1%) in 2006. | 18279464 |
| Dyslipidemias, Chronic Kidney Diseases, Coronary heart disease | Deregulated Nutrient Sensing | We assessed sociodemographic and clinical data, cardiovascular risk factors, coronary disease risk categories, dyslipidemia characteristics, functional CKD stage, and pharmacological treatments. | 18279629 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Metformin improved glycemic control and reduced insulin resistance in obese type 2 diabetes mellitus patients. | 18280440 |
| Hyperglycemia | Deregulated Nutrient Sensing | Initial insulin therapy led to rapid reduction in hyperglycemia with reduced insulin resistance. | 18280440 |
| Colorectal, Increased insulin level, Acromegaly | Deregulated Nutrient Sensing | Is there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly? | 18283256 |
| Colorectal, Acromegaly | Deregulated Nutrient Sensing | To evaluate a relation between insulin level, insulin resistance and its anthropometric markers and colorectal lesions in patients with acromegaly. | 18283256 |
| Increased insulin level, Acromegaly, Pathology | Deregulated Nutrient Sensing | The study results show a relation between hyperinsulinemia, insulin resistance and colon pathologies in acromegaly. | 18283256 |
| Kidney Failure, Chronic, Inflammation | Deregulated Nutrient Sensing | The cornerstone of high CVD incidence in ESRD patients is endothelial dysfunction which results from inflammation, oxidative stress and insulin resistance. | 18285698 |
| HD Term Type | Deregulated Nutrient Sensing | For patients receiving HD, the high-flux dialyzer with synthetic polysulfone membranes fails to provide a better anti-inflammatory or antioxidative effect than the low-flux dialyzer; however, the high-flux dialyzer does significantly improve insulin resistance in this short-term study. | 18285698 |
| Fatty Liver | Deregulated Nutrient Sensing | Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. | 18286258 |
| Obesity | Deregulated Nutrient Sensing | Our data suggest that high hepatic SCD1 activity may regulate fat accumulation in the liver and possibly protects from insulin resistance in obesity. | 18286258 |
| Hepatitis C, Chronic, Hepatitis C, Hepatitis B, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients. | 18290778 |
| Renal Insufficiency, Dyslipidemias, Diabetes Mellitus, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Baseline differences in demography, cardiovascular risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia, renal impairment), and severity of peripheral arterial disease (ankle-brachial indices, TcPO(2), prior arterial reconstruction) were not significant. | 18295105 |
| Obesity | Deregulated Nutrient Sensing | Overweight or obesity and insulin resistance were prevalent. | 18300117 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | CAD risk factors were hypertension (53%), dyslipidemia (48%), smoking (34%) and diabetes (34%). | 18301868 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Despite associations with total adiponectin and insulin resistance, our data go against any apparent association between HMW adiponectin levels and incident CHD events. | 18303082 |
| Hyperglycemia | Deregulated Nutrient Sensing | Insulin resistance, hyperglycaemia, diastolic blood pressure and MMP-9 levels were also reduced (P < 0.017). | 18307460 |
| Prostate carcinoma, Obesity | Deregulated Nutrient Sensing | Adipocytokines, obesity, and insulin resistance during combined androgen blockade for prostate cancer. | 18308111 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidaemia as a predictor of hypertension in middle-aged men. | 18308688 |
| Atherosclerosis | Deregulated Nutrient Sensing | The independent contribution of insulin resistance to atherosclerosis is still under debate. | 18309150 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Overweight, elevated waist circumference, hypertension, and dyslipidemia were more prevalent in the city. | 18310309 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Metabolic risk factors, insulin-resistance and lifestyle in children of type 2 diabetes patients in Karachi, Pakistan. | 18313164 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To assess metabolic risk factors, insulin-resistance and lifestyle in children aged 8-20 years of patients with type 2 diabetes and to compare these with children aged 8-20 years of non-diabetic subjects. | 18313164 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The presence of abdominal obesity and dyslipidemia in men and abdominal obesity in women revealed positive impacts on uric acid levels. | 18314213 |
| Steatohepatitis, Non-alcoholic Fatty Liver Disease, Hyperglycemia | Deregulated Nutrient Sensing | Nonalcoholic fatty liver, affecting 34% of the U.S. population, is characterized by hepatic insulin resistance, which is more marked in the presence of steatohepatitis, and frequently precedes hyperglycemia. | 18316359 |
| Fatty Liver | Deregulated Nutrient Sensing | The molecular mechanisms underlying the relationship between fatty liver and insulin resistance are still undergoing definition and have not been evaluated in humans. | 18316359 |
| Steatohepatitis | Deregulated Nutrient Sensing | FOXO1 expression and activity are increased in patients with steatohepatitis, and mRNA levels are correlated with hepatic insulin resistance. | 18316359 |
| HIV, Dyslipidemias | Deregulated Nutrient Sensing | Treatment of human immunodeficiency virus (HIV) with protease inhibitors (PIs) is associated with insulin resistance, triglyceride-rich dyslipidemia, and fat redistribution. | 18317438 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was present in 77.8%, diabetes in 27.8% and dyslipidemia in 32.4%. | 18317619 |
| Acute Coronary Syndrome, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | The relationship between coronary artery disease (CAD) and dyslipidemia in acute coronary syndromes has been rarely demonstrated in clinical and epidemiological studies. | 18317637 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Low testosterone levels are common and associated with insulin resistance in men with diabetes. | 18319314 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance. | 18319314 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes. | 18319314 |
| Obesity | Deregulated Nutrient Sensing | Thus, TNF-alpha may contribute to the insulin resistance of overall obesity, whereas IL-6 may be one of the mediators of the hyperinsulinemic state specifically related to excess visceral adiposity. | 18319319 |
| Hyperhomocysteinemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and hyperhomocysteinemia are independent risk factors for the occurrence of recurrent CRVO. | 18320516 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Postprandial chylomicrons and adipose tissue lipoprotein lipase are altered in type 2 diabetes independently of obesity and whole-body insulin resistance. | 18321693 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Postprandial lipoprotein abnormalities in type 2 diabetes are associated with insulin resistance. | 18321693 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The aim of this study is to differentiate the effects of whole-body insulin resistance, obesity, and type 2 diabetes on postprandial dyslipidaemia and lipoprotein lipase (LPL) in adipose tissue. | 18321693 |
| Atherosclerosis | Deregulated Nutrient Sensing | Designed as a cross-sectional, epidemiologic study, the Insulin Resistance Atherosclerosis Study was conducted in four centers: San Antonio (Texas), San Luis Valley (Colorado), and Oakland and Los Angeles (California). | 18322051 |
| Impaired cognition, Anemia, Obesity | Deregulated Nutrient Sensing | In the elderly, a combination of high folate levels and low vitamin B-12 status may be associated with an increased risk of cognitive impairment and anemia and, in pregnant women, with an increased risk of insulin resistance and obesity in their children. | 18326588 |
| Cerebrovascular Disorders, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Population II was comprised of 158 subjects with or without either CAD or cerebro-vascular disease, and matched for age, sex, smoking status, weight category and the presence of hypertension, dyslipidemia, and diabetes. | 18327409 |
| Dyslipidemias, Cardiovascular Diseases, diabetic | Deregulated Nutrient Sensing | Dyslipidemia is still under-treated despite the availability of effective pharmacological agents and the greatly increased risk of cardiovascular diseases in diabetic patients. | 18330400 |
| Hypertension, CTCAE, Psoriasis, Dyslipidemias | Deregulated Nutrient Sensing | Dermatologists taking care of patients with psoriasis should be aware of this association and advise the patients to reduce additional risk factors such as smoking, hypertension or dyslipidemia. | 18331320 |
| Hyperglycemia | Deregulated Nutrient Sensing | Post-operative insulin resistance and hyperglycaemia are associated with an impaired outcome after surgery. | 18331374 |
| Hyperglycemia | Deregulated Nutrient Sensing | Pre-operative oral carbohydrate loading (CHO) reduces post-operative insulin resistance with a reduced risk of hyperglycaemia during post-operative nutrition. | 18331374 |
| Lipolysis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists such as thiazolidinediones (TZDs) improve insulin sensitivity in type 2 diabetes mellitus (T2DM) through effects on fat metabolism whereas GH stimulates lipolysis and induces insulin resistance. | 18331610 |
| Turner Syndrome, Dyslipidemias, Obesity, Hypertension, CTCAE, Impaired T cell function | Deregulated Nutrient Sensing | The primary pathogenic event is beta cell dysfunction, but insulin resistance also plays a central role and is worsened by the presence of hypertension, obesity and dyslipidemia which are common in Turner syndrome. | 18333365 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | blood pressure, dyslipidemia, diabetes, obesity, smoking, alcohol intake, physical activity and fruit and vegetable intake. | 18335048 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. | 18335327 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Individuals with at least one risk factor of type 2 diabetes should have screening test to diagnose glucose intolerance. | 18335394 |
| Dyslipidemias, Uterine Fibroids | Deregulated Nutrient Sensing | To analyze the possible association between insulin resistance and dyslipidemia with uterine fibroids, using objective metabolic measurements. | 18336822 |
| Uterine Fibroids | Deregulated Nutrient Sensing | Insulin resistance was not shown to be a risk factor for fibroids. | 18336822 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A single nucleotide polymorphism (S89N) in the gene encoding U-II (UTS2) is associated with the onset of Type 2 diabetes and insulin resistance in the Japanese population. | 18338983 |
| Diabetes Mellitus, Insulin-Dependent, Glucose Intolerance (disease), Impaired health | Deregulated Nutrient Sensing | Development of glucose metabolism impairment ranging from glucose intolerance to insulin-dependent diabetes is observed in the evolution of these patients. | 18339976 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The study purpose was to compare the prevalence of dyslipidemia between a self-reported survey, Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD), and survey and laboratory data from National Health and Nutrition Examination Survey (NHANES 1999-2002). | 18346311 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Components of dyslipidemia were uniformly less in SHIELD than NHANES: high TC = 17 vs. 35%, high LDL-C = 10 vs. 14%, high TG = 7 vs. 17% and low HDL-C = 5 vs. 24%; all comparisons p < 0.01. | 18346311 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia prevalence was lower in self-reported SHIELD than the objectively assessed NHANES, with especially low self-report of high TG and low HDL-C. Self-reported prevalence of dyslipidemia may under-report the prevalence based on laboratory data. | 18346311 |
| HD Term Type, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Unfortunately, growing number of type 2 diabetic hemodialysis (HD) patients with insulin resistance are now being diagnosed in Japan. | 18346811 |
| Childhood onset fluency disorder | Deregulated Nutrient Sensing | The effects of childhood-onset diabetes and insulin resistance in nondiabetic individuals on SHBG and testosterone in children and young adults are poorly understood. | 18346991 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In those without diabetes, greater insulin resistance had a small, nonsignificant association with lower SHBG and higher free testosterone. | 18346991 |
| Pulmonary Emphysema, Cachexia | Deregulated Nutrient Sensing | Pulmonary emphysema is associated with cachexia and disregulation of the hormones regulating the glycolipid metabolism, insulin resistance, and altered substrate utilization. | 18347203 |
| Stanford Cancer Institute | Deregulated Nutrient Sensing | The increased levels of IMCL might interfere with the glucose uptake in skeletal muscle; potentially predisposing persons with incomplete SCI to the development of peripheral insulin resistance. | 18347608 |
| Hyperhomocysteinemia, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | However, these patients did demonstrate risk factors such as dyslipidemia and hyperhomocysteinemia for the development of atherosclerosis. | 18348424 |
| Acromegaly | Deregulated Nutrient Sensing | IMAT is greater in acromegaly, a novel finding, which suggests that increased AT in muscle could be associated with GH-induced insulin resistance. | 18349062 |
| Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Little is known about the association of endothelial nitric oxide synthase (NOS3) gene polymorphisms and the presence of insulin resistance and the early evolution of atherosclerosis in nondiabetic subjects with cardiovascular disease (CAD) and stent implantation. | 18349107 |
| Weight decreased | Deregulated Nutrient Sensing | Weight loss of 3-7% body weight yielded greater decreases in 2-h glucose (P < 0.01), insulin concentration (P < 0.04), and insulin resistance (P < 0.03) in men than in women. | 18356403 |
| Edema, Dyslipidemias, Disorder of macula due to diabetes mellitus | Deregulated Nutrient Sensing | Association of dyslipidaemia with macular oedema and hard exudates in diabetic maculopathy. | 18356786 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | It has been observed that the appearance of hard exudates is consistent with the appearance of dyslipidaemia, which is typical for diabetic patients. | 18356786 |
| Obesity, Visceral | Deregulated Nutrient Sensing | Contribution of the lean body mass to insulin resistance in postmenopausal women with visceral obesity: a Monet study. | 18356851 |
| Ventricular Fibrillation | Deregulated Nutrient Sensing | The contribution of VF to insulin resistance seems to be exacerbated by increased LBM in PM women. | 18356851 |
| Renal Insufficiency, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is believed to be associated with the development of renal dysfunction. | 18359317 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | It is well known that obesity and insulin resistance are closely related to the development of type 2 diabetes. | 18360022 |
| Kidney Diseases | Deregulated Nutrient Sensing | However, the exact pathogenic mechanism underlying the insulin resistance in renal disease has not been clarified. | 18360022 |
| HD Term Type | Deregulated Nutrient Sensing | In conclusion, insulin resistance and CRP were related to fat-related parameters such as BMI, VFA and SFA in HD patients. | 18360022 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | Although the prevalences of all of the disorders showed significant progression from the sustained NT group towards the WCH and HT groups, the prevalence of dyslipidemia was significantly higher in the WCH group (P < 0.05 for all). | 18360067 |
| Demographics Domain, Atherosclerosis, Dyslipidemias, Haiti, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Due to the gradually increased prevalences of obesity, IGT or DM, and CHD from the sustained NT group towards the WCH and HT groups and the highest prevalence of dyslipidemia in the WCH group, WCH should preferentially be accepted as an alarming sign of a deterioration in health rather than being a predisposing factor of HT or atherosclerosis alone. | 18360067 |
| Dyslipidemias, Obesity, Haiti | Deregulated Nutrient Sensing | The significantly higher prevalence of dyslipidemia in the WCH group than in the HT group may be explained by the increased amount of adipose tissue in the HT cases, since the prevalence of obesity was the highest in the HT group. | 18360067 |
| Weight Gain, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Thus, the high prevalence of WCH even in early decades may represent increased susceptibility to future weight gain, and dyslipidemia in patients with WCH may be a preliminary sign of obesity. | 18360067 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | Therefore, the management of WCH should focus on the prevention of dyslipidemia and excess weight gain. | 18360067 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Determinants of poor LDL cholesterol control were no lipid-lowering treatment, no previous diagnosis of ischemic heart disease, no antihypertensive treatment, and dyslipidemia. | 18361907 |
| Dyslipidemias, GDC Disease Response Terminology | Deregulated Nutrient Sensing | Clinical studies suggest that dyslipidemia is associated with the initiation and progression of DR. | 18362112 |
| Acromegaly | Deregulated Nutrient Sensing | We therefore studied intra-abdominal fat and insulin resistance in acromegalic patients after a 3-month octreotide-washout period, i.e., during untreated acromegaly, and during PEG treatment. | 18362292 |
| Lipolysis, Acromegaly, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Acromegalic patients have increased lipolysis and decreased fat mass as well as reduced insulin sensitivity and glucose intolerance. | 18362292 |
| Atherosclerosis | Deregulated Nutrient Sensing | BACKGROUND Peroxisome proliferator-activated receptor gamma (PPARgamma) is involved mainly in adipocyte differentiation and has been suggested to play an important role in the pathogenesis of insulin resistance (IR) and atherosclerosis. | 18362424 |
| Sleep Apnea, CTCAE, Sleep Apnea, Obstructive, Obesity | Deregulated Nutrient Sensing | Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea. | 18365276 |
| Sleep Apnea, CTCAE | Deregulated Nutrient Sensing | The aim of the study was to investigate the association of sleep apnea severity with insulin resistance, leptin, and CRP levels in a cohort of male patients. | 18365276 |
| Sleep Apnea, Obstructive, Sleep Apnea, CTCAE, Obesity | Deregulated Nutrient Sensing | Insulin resistance estimated by the HOMA method in male patients with OSAS was not associated with sleep apnea severity independent of obesity. | 18365276 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | There is evidence that dyslipidemia is associated with chronic kidney disease (CKD). | 18366658 |
| Dyslipidemias, Obesity, Visceral | Deregulated Nutrient Sensing | Moreover, the genotype 877C/T contributed to both dyslipidemia and high FPG independent of age, sex, and visceral obesity. | 18370833 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, male gender, and waist circumference were positively associated with a high ABI, and smoking and dyslipidemia were inversely associated with a high ABI. | 18371562 |
| Albuminuria, Dyslipidemias, Diabetes Mellitus, Renal Insufficiency, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of albuminuria and renal dysfunction on development of dyslipidaemia in type 2 diabetes--the Hong Kong Diabetes Registry. | 18372388 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A prospective cohort of 2761 type 2 diabetic patients without significant dyslipidaemia and having at least one measurement of TC, LDL-C and HDL-C during 2.8 years of follow-up was analysed. | 18372388 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance frequently occurs in non-diabetic patients with cardiovascular disease. | 18374336 |
| Biliary calculi, Biliary Tract Cancer, Obesity | Deregulated Nutrient Sensing | Obesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary cancer. | 18375961 |
| Inflammation, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The association between obesity and hypertension was positive and direct (B=0.43, p<0.01) without the intermediation of inflammation or insulin resistance. | 18378435 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Our study has demonstrated that obesity plays the central role in leading to hypertension and a pro-inflammatory state, insulin resistance and dyslipidaemia. | 18378435 |
| Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Elevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD). | 18381580 |
| Somatotropin deficiency | Deregulated Nutrient Sensing | Low-dose GH replacement in women with GHD decreased total and visceral adipose tissue and improved cardiovascular markers, with a relatively modest increase in IGF-1 levels and without worsening insulin resistance. | 18381581 |
| Obesity | Deregulated Nutrient Sensing | Obesity, particularly central obesity, is considered as a systemic inflammatory condition and is related strongly to insulin resistance. | 18383516 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | The current results suggested that, in the Chinese population that was studied, obesity-related insulin resistance and proinflammatory effects may play an important role in endometrial cancer risk, and these effects were modified significantly by the CRP SNP rs1130864. | 18383516 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Dyslipidemia was documented in 50% of diabetic patients. | 18383562 |
| Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | During this time, obesity, insulin resistance and the metabolic syndrome have also increased in prevalence. | 18384705 |
| Dyslipidemias, atherosclerotic, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Twenty five patients (67%) had other atherosclerotic risk factors such as smoking, dyslipidemia, hypertension and diabetes. | 18386616 |
| Thrombus, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Both the thrombotic risk and the probability of stenosis detection were augmented by additional risk factors such as smoking, hypertension and dyslipidemia. | 18386616 |
| Impaired T cell function | Deregulated Nutrient Sensing | We have demonstrated in the present study the predominant role of beta cell dysfunction as compared to that of insulin resistance in the deterioration of glucose tolerance in non-obese women. | 18389389 |
| Dyslipidemias, Myocardial Infarction, Cerebrovascular accident, Heart Diseases, Diabetes Mellitus, Obesity, Overweight | Deregulated Nutrient Sensing | Familial antecedents with risk for AHT were assessed: EAHT (36.7%), ischemic cardiopathy (13.3%), myocardial infarct (13.7%), stroke (15%), diabetes mellitus (13.2%), obesity (27.5%), and dyslipidemia (31.8%), as well as body mass index (BMI)--34.9% overweight persons and 32.9% suffering from obesity; repartition on blood groups, behaviour type (A--67.8%), sedentary lifestyle (35.8%), stress (extra-familial--32.1%), active tobacco smoking (52.1%), excess coffee (> 3 cup daily--35.7%), alcohol (10.1%) and salt (31.0%) consumption. | 18389797 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The major medical history was hypertension (74.9%), followed by dyslipidemia (54.4%), diabetes mellitus (26.6%), and ischemic heart disease (18.0%). | 18389988 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and its co-morbidities are often present in patients with NAFLD. | 18390575 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Atherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease. | 18390868 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Adiponectin is closely related to atherogenic dyslipidaemia and may be a clinical important mediator of recurrent coronary heart disease (CHD). | 18390868 |
| Dyslipidemias | Deregulated Nutrient Sensing | In contrast, LDL-cholesterol and markers of atherogenic dyslipidaemia were independently associated with secondary CVD events (relative risk per unit increase: LDL-cholesterol: 1.54; 95%CI 1.18-2.01; P = 0.001, triglycerides: 1.58; 95%CI 1.31-1.90; P < 0.0001 and HDL-cholesterol: 0.34; 95%CI 0.14-0.79; P = 0.01). | 18390868 |
| Dyslipidemias | Deregulated Nutrient Sensing | In contrast, approaching atherogenic dyslipidaemia may represent a promising target in secondary prevention programs for high-risk patients. | 18390868 |
| Ischemic myocardial dysfunction | Deregulated Nutrient Sensing | Myocardial scar and insulin resistance predict cardiovascular events in severe ischaemic myocardial dysfunction: a perfusion-metabolism positron emission tomography study. | 18391729 |
| Dyslipidemias, Diabetes Mellitus, Claudication (finding), CLU protein, human, Kidney Failure | Deregulated Nutrient Sensing | While in the CLI group, patients were older, with higher rates of female sex, diabetes (62% vs. 48%, p<0.001) and severe renal failure, claudicants were significantly younger, with higher rates of smokers among men (75% vs. 51%, p<0.001) and moderate dyslipidemia (52% vs. 36%, p<0.001). | 18391869 |
| ACSM3 gene, Dyslipidemias, Diabetes Mellitus, Musculoskeletal Pain, Acyl Carrier Protein | Deregulated Nutrient Sensing | the prevalence of CAD among RVHD patients is low, whereas it is high among NVHD patients; the rheumatic etiology does not seem to have any beneficial effects on the prevalence of CAD; gender, age, SAH, TACP, dyslipidemia and diabetes were identified as being strongly associated with the presence of CAD. | 18392400 |
| Allergic sensitization, Asthma, Obesity | Deregulated Nutrient Sensing | Association of obesity and insulin resistance with asthma and aeroallergen sensitization. | 18394132 |
| Asthma, Obesity, Allergy - Charge Type Reason | Deregulated Nutrient Sensing | It has been hypothesized that obesity and insulin resistance may play a role in the development of asthma and allergy. | 18394132 |
| Allergic sensitization, Allergic asthma, Intrinsic asthma | Deregulated Nutrient Sensing | Insulin resistance was asssociated with aeroallergen sensitization and allergic asthma, but not nonallergic asthma. | 18394132 |
| Allergic asthma, Obesity, Intrinsic asthma | Deregulated Nutrient Sensing | The associations of obesity with aeroallegen sensitization and allergic asthma became nonsignificant after adjustment for insulin resistance, whereas the association of obesity with nonallergic asthma was unaffected. | 18394132 |
| Allergic sensitization, Allergic asthma, Obesity | Deregulated Nutrient Sensing | Obesity may be related to an increased risk of aeroallergen sensitization and allergic asthma through mechanisms also involved in the development of insulin resistance. | 18394132 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance has been assigned a pivotal role in the pathological progression associated with type 2 diabetes and other chronic metabolic diseases. | 18395354 |
| Non-alcoholic Fatty Liver Disease, Hepatitis | Deregulated Nutrient Sensing | Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase. | 18397231 |
| Hepatitis C | Deregulated Nutrient Sensing | Recent studies using transgenic mouse models have demonstrated that the presence of hepatitis C virus (HCV) singularly induces insulin resistance (IR). | 18397231 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, to date, the various associations between factors related to the course of type 2 diabetes, like metabolic compensation, beta cell secretory dysfunction, insulin resistance and IL-12 serum levels, remain unclear. | 18397831 |
| Atherosclerosis | Deregulated Nutrient Sensing | This finding gives us hope that treatment to decrease peripheral insulin resistance and to avoid excessive proinsulin secretion might be successful in the prevention of IL-12-induced atherosclerosis. | 18397831 |
| Hand muscle atrophy | Deregulated Nutrient Sensing | Using PABPN1 nematodes that show muscle cell degeneration and abnormal motility, we found that increased dosage of the sirtuin and deacetylase sir-2.1/SIRT1 exacerbated muscle pathology, an effect dependent on the transcription factor daf-16/FoxO and fuel sensor aak-2/AMPK (AMP-activated protein kinase), while null mutants of sir-2.1, daf-16 and aak-2 were protective. | 18397876 |
| Muscular Dystrophy, Oculopharyngeal | Deregulated Nutrient Sensing | Altogether, our data identify Sir2 and AMPK inhibition as therapeutic strategies for muscle protection in OPMD, extending the value of druggable proteins in cell maintenance networks to polyalanine diseases. | 18397876 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. | 18397984 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | In vitro and in vivo studies have then showed its effects on hyperglycemia and dyslipidemia. | 18397984 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The objective of the study was to evaluate the efficacy and safety of berberine in the treatment of type 2 diabetic patients with dyslipidemia. | 18397984 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | One hundred sixteen patients with type 2 diabetes and dyslipidemia were randomly allocated to receive berberine (1.0 g daily) and the placebo for 3 months. | 18397984 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia. | 18397984 |
| Malnutrition, Chronic inflammation, Atherosclerosis, Dyslipidemias, Cessation of life | Deregulated Nutrient Sensing | Atherosclerotic cardiovascular disease is the most common cause of death among hemodialysis patients; it has been attributed to increased oxidative stress, dyslipidemia, malnutrition, and chronic inflammation. | 18400731 |
| Presenile dementia, Glucose Intolerance (disease), Impaired cognition | Deregulated Nutrient Sensing | Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment. | 18401020 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Kidney Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | In particular patients having additional cardiac risk factors like diabetes mellitus, dyslipidemia, increased waist circumference as well as concomitant diseases like myocardial infarction, heart- as well as kidney failure would benefit from an effective antihypertensive therapy. | 18402243 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance. | 18402781 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aims of this study were to measure serum levels of brain-derived neurotrophic factor (BDNF) in patients with type 2 diabetes mellitus (T2DM) and to investigate the association of these BDNF levels with biomarkers of glucose metabolism and insulin resistance. | 18402781 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | This parameter should be considered in addition to other well-known risk factors such as diabetes, hypertension, smoking, and dyslipidemia. | 18404269 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined whether reduction of both non-oxidative glucose disposal and glucose oxidation contributes to insulin resistance in type 2 diabetes. | 18410564 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In addition, exercise improves insulin resistance mainly by increasing non-oxidative glucose disposal in type 2 diabetes. | 18410564 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Two of four major cardiac risk factors (hypertension and diabetes) were recorded in 90% of patient records; however, arguably the most important reversible risk factors for cardiac disease (dyslipidemia and smoking) were only reported 80% of the time. | 18411042 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate the effects of extended-release metformin (MXR) compared with immediate-release metformin (MIR) on post-prandial glycaemic excursion, chronic glycaemia, lipid profiles, insulin resistance and islet function in type 2 diabetes. | 18412932 |
| diabetic | Deregulated Nutrient Sensing | Diabetic patients with poor glycemic control may be associated with neuronal dysfunction/damage in brain in accordance with A1C levels and, in some, extend with insulin resistance. | 18413166 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance following cardiothoracic surgery in patients with and without a preoperative diagnosis of type 2 diabetes during treatment with intravenous insulin therapy for postoperative hyperglycemia. | 18413197 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To assess insulin resistance postoperatively in patients with (DM) and without (nonDM) a prior diagnosis of diabetes. | 18413197 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustments were made for age, race, ethnicity, and sex in the quasi-Poisson model, CCS was associated with hypertension, dyslipidemia, and diabetes (P < .001 for all diseases). | 18413889 |
| Malignant tumor of colon, Neoplastic Cell Transformation | Deregulated Nutrient Sensing | The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. | 18414679 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a diet that broadly suppresses cancer in mammals. | 18414679 |
| Malignant tumor of colon, Neoplasms | Deregulated Nutrient Sensing | Here we show that CR induces a two-fold increase SIRT1 expression in the intestine of rodents and that ectopic induction of SIRT1 in a beta-catenin-driven mouse model of colon cancer significantly reduces tumor formation, proliferation, and animal morbidity in the absence of CR. | 18414679 |
| Colonic Neoplasms | Deregulated Nutrient Sensing | Consistent with this, a significant inverse correlation was found between the presence of nuclear SIRT1 and the oncogenic form of beta-catenin in 81 human colon tumor specimens analyzed. | 18414679 |
| Intestinal Neoplasms | Deregulated Nutrient Sensing | Taken together, these observations show that SIRT1 suppresses intestinal tumor formation in vivo and raise the prospect that therapies targeting SIRT1 may be of clinical use in beta-catenin-driven malignancies. | 18414679 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance improved in 38% of the 21 patients with diabetes mellitus. | 18415756 |
| Coronary heart disease | Deregulated Nutrient Sensing | Coronary heart disease likelihood, significantly associated with Lp(a) concentrations, is independent of MS and insulin resistance. | 18418227 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The objective of our study was to determine values of key lipid and lipoprotein fractions in PCOS, and their possible relation to insulin resistance. | 18418429 |
| Prostate Cancer Outcomes Study, Dyslipidemias | Deregulated Nutrient Sensing | PCOS patients compared with controls had increased indices of insulin resistance, basal insulin (p < 0.001), and HOMA index (p < 0.001), and worsened insulin resistance-related dyslipidemia with decreased HDL cholesterol (p < 0.01), elevated triglycerides (p = 0.010), and pronounced LDL oxidation (p < 0.001). | 18418429 |
| Prostate Cancer Outcomes Study, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, characteristic dyslipidemia of insulin resistance and unfavorable proatherogenic lipoprotein ratios were present only in women with PCOS and not in controls. | 18418429 |
| Prostate Cancer Outcomes Study, Precocious atherosclerosis | Deregulated Nutrient Sensing | Elevated OxLDL and the relation of apoE and nonesterified fatty acids with insulin resistance suggest that women with PCOS are at increased risk for premature atherosclerosis. | 18418429 |
| Inflammation | Deregulated Nutrient Sensing | T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. | 18420999 |
| Inflammation | Deregulated Nutrient Sensing | Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). | 18420999 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | In conclusion, FABP4 plasma concentrations hold strong potential for development as a clinical biomarker for atherogenic dyslipidemia, independent of obesity and insulin resistance, in type 2 diabetic subjects. | 18421072 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes. | 18421072 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Type 2 diabetic subjects were categorized according the presence of atherogenic dyslipidemia. | 18421072 |
| Dyslipidemias | Deregulated Nutrient Sensing | High FABP4 and low adiponectin levels are independent predictors of atherogenic dyslipidemia. | 18421072 |
| Microalbuminuria, White matter lesions, diabetic | Deregulated Nutrient Sensing | The role of microalbuminuria and insulin resistance as significant risk factors for white matter lesions in Japanese type 2 diabetic patients. | 18423105 |
| Microalbuminuria, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with microalbuminuria and insulin resistance in patients with type 2 diabetic mellitus (DM) not receiving insulin treatment. | 18423105 |
| Microalbuminuria | Deregulated Nutrient Sensing | Multivariate logistic analysis revealed that WML was independently predicted by the microalbuminuria and insulin resistance (p<0.005, p<0.0005, respectively). | 18423105 |
| Microalbuminuria | Deregulated Nutrient Sensing | The results of this preliminary study indicate that the presence of WML was associated with the microalbuminuria and insulin resistance in these Japanese patients with type 2 DM; larger cohort studies are warranted to confirm these findings. | 18423105 |
| Hyperglycemia | Deregulated Nutrient Sensing | Despite insulin resistance, however, obese patients did not incur longer periods of hyperglycemia. | 18426344 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | About 50% of the patients with diabetes were more often female, with a greater prevalence of hypertension and dyslipidemia. | 18431886 |
| Familial benign pemphigus, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Obesity, Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension and hypertensive heart disease (HHD) are inter-related phenotypes frequently observed with other comorbidities such as diabetes, obesity, and dyslipidemia, which probably reflect the complex gene-gene and/or gene-environment interactions resulting in HHD. | 18435473 |
| Breast Carcinoma | Deregulated Nutrient Sensing | High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome. | 18437560 |
| Breast Carcinoma | Deregulated Nutrient Sensing | High insulin levels in women with locoregional breast cancer reflect the presence of insulin resistance and are associated with other components of the IRS. | 18437560 |
| Tumor necrosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Leptin and tumor necrosis factor-alpha (TNF-alpha) play important role in homeostasis and insulin resistance in the treatment of Type 2 diabetes (T2DM). | 18438653 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease. | 18438697 |
| Data types - Address | Deregulated Nutrient Sensing | We conclude that there is no real association with SNPs available in the present study between SIRT1, PPARD or PGC-1alpha genes and AD risk in the Finnish population. | 18438697 |
| Heart Diseases, Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | Diet has been related to several characteristics of metabolic syndrome (MSDR) and insulin resistance, which carry an increased risk for diabetes and heart disease. | 18442502 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To examine the cross-sectional association between macronutrient intake, sex, and MSDR and insulin resistance in American Indians without diabetes. | 18442502 |
| Cerebrovascular Disorders, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus | Deregulated Nutrient Sensing | Although they had increased risk factors, including previous stroke (30 of 203 vs 16 of 244, p = 0.004), diabetes (66 of 203 vs 32 of 244, p < 0.0001), cerebrovascular disease (45 of 203 vs 24 of 244, p = 0.003), and dyslipidemia (191 of 203 vs 63 of 244, p < 0.0001), they had better outcomes. | 18442531 |
| Restenosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Robust evidence demonstrates that diabetes mellitus and insulin resistance are among the main risk factors for restenosis in patients requiring percutaneous myocardial revascularization. | 18442619 |
| Critical Illness | Deregulated Nutrient Sensing | Prevalence, incidence, and clinical resolution of insulin resistance in critically ill patients: an observational study. | 18443133 |
| Critical Illness | Deregulated Nutrient Sensing | The primary objective of this study was to measure the prevalence, incidence, and resolution of insulin resistance (IR) in critically ill patients. | 18443133 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Selective thyromimetics for atherosclerosis and dyslipidaemia: another old target making progress. | 18447589 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The history of thyromimetics in atherosclerosis and dyslipidaemia is reviewed as the background to the recent publication of the first human data on a new selective thyromimetic, KB-2115 (eprotirome). | 18447589 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Effectiveness of a fenofibrate 145-mg nanoparticle tablet formulation compared with the standard 160-mg tablet in patients with coronary heart disease and dyslipidemia. | 18447655 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | To compare the effectiveness of a fenofibrate 145-mg nanoparticle tablet formulation with the standard 160-mg tablet in patients with dyslipidemia and coronary heart disease. | 18447655 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hypertension was reported in 53%, obesity in 27%, dyslipidemia in 26%, and diabetes in 23% of the patients. | 18448013 |
| Hormone abnormality, Cardiovascular Diseases | Deregulated Nutrient Sensing | Clinical studies suggest that menstrual irregularities are associated with metabolic and hormonal abnormalities, insulin resistance and a hyperestrogenic/hyperandrogenic imbalance, that may influence the risk of cardiovascular disease. | 18450435 |
| Inflammation, Albuminuria, Obesity, Congestive heart failure | Deregulated Nutrient Sensing | Recently, increasing interest has emerged on the potential role of novel risk factors such as systemic inflammation, insulin resistance, and albuminuria in the pathophysiology of CHF and their relationship with obesity. | 18452784 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Most patients exhibited cardiovascular risk factors other than dyslipidemia: hypertension in 34%, diabetes in 11%, and smoking in 18%. | 18456039 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance is a risk factor for NASH and GD. | 18459024 |
| Gall Bladder Diseases, Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance was more common in concurrent NASH and gallbladder disease. | 18459024 |
| Fibrosis Assessment, Gall Bladder Diseases, Fatty Liver Disease | Deregulated Nutrient Sensing | The mechanism between insulin resistance, fibrosis stage, NASH, and gallbladder disease is unknown. | 18459024 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In persons with impaired glucose tolerance (IGT), both impaired insulin secretion and insulin resistance contribute to the conversion to type 2 diabetes mellitus (T2DM). | 18460558 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We investigated the association of -1131T>C and S19W polymorphisms with diabetic dyslipidemia in 400 Caucasian T2D patients divided in 2 groups: group N with 130 normotriglyceridemics (TG<90th percentile) and group M with 270 moderately hypertriglyceridemics. | 18468520 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results suggest that in T2D APOA5 polymorphisms contribute to modulate dyslipidemia. | 18468520 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and type 2 diabetes are associated with an atherogenic lipoprotein profile. | 18469202 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined the role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated with type 2 diabetes. | 18469202 |
| Dyslipidemias | Deregulated Nutrient Sensing | Impact of dyslipidaemia on arterial structure and function in urban indigenous Australians. | 18471818 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia (low HDL-cholesterol or elevated triglycerides) is independently associated with non-invasive measures of cardiovascular disease in a relatively healthy and young subgroup of this high-risk population. | 18471818 |
| Cerebrovascular Disorders | Deregulated Nutrient Sensing | On the other hand, insulin resistance represents an independent factor in the etiology of age-associated coronary and cerebrovascular disease. | 18473910 |
| Federated States of Micronesia | Deregulated Nutrient Sensing | The present study may suggest possible involvement of adiponectin in bone metabolism, independently of FM and insulin resistance even in elderly post-menopausal women. | 18475046 |
| Weight decreased | Deregulated Nutrient Sensing | Short-term dietary weight loss can improve insulin resistance but long-term studies are lacking. | 18476986 |
| diabetic | Deregulated Nutrient Sensing | Thiazolidine derivatives increase circulating adiponectin, particularly the high molecular weight isoform, which has been shown to well correlate with amelioration of insulin resistance by thiazolidines in diabetic patients. | 18480556 |
| Diabetes Mellitus, Non-Insulin-Dependent, square decimeter, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD). | 18482457 |
| Coronary Stenosis | Deregulated Nutrient Sensing | Association of insulin resistance with de novo coronary stenosis after percutaneous coronary artery intervention in hemodialysis patients. | 18483462 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance may be involved in the progression of nonculprit coronary atherosclerosis after PCI in hemodialysis patients. | 18483462 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The gender, age, incidence of hypertension, diabetics, smoking, and dyslipidemia were similar among the three groups. | 18484157 |
| Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To reveal the exact link between adipose tissue, inflammation, and cardiovascular disease (CVD), we studied the association of C-reactive protein (CRP) with insulin resistance and adipocytokines in Asian Indian subjects. | 18484906 |
| Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | The association of CRP with insulin resistance, adipocytokines, and resistin reveals close links between inflammation, CVD, and adipose tissue. | 18484906 |
| Communicable Diseases, Steatohepatitis, Hepatitis C, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. Hepatitis C virus (HCV) infection disturbs glucose and lipid metabolism contributing to the development of liver steatosis, insulin resistance and type 2 diabetes mellitus. | 18486982 |
| Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | On the other hand, insulin resistance and steatosis have been found to be associated with increased rates of fibrosis progression and lower rates of response to interferon therapy in chronic hepatitis C (CHC). | 18486982 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | The molecular mechanisms contributing to insulin resistance in CHC are not well understood. | 18486982 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | HCV-induced over-expression of PP2A in the liver contributes to the pathogenesis of insulin resistance in patients with CHC. | 18486982 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. | 18488190 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Adverse levels of adipokines are associated with insulin resistance in individuals at low or high diabetes risk. | 18492747 |
| Diabetes Mellitus, Non-Insulin-Dependent, square decimeter, Obesity | Deregulated Nutrient Sensing | Adaptation to states of enhanced metabolic demand is associated with increased glucose metabolism and GLUT4 gene expression, whereas states of insulin resistance such as type 2 diabetes mellitus (DM2), obesity, and aging are associated with impaired regulation of GLUT4 gene expression and function. | 18492767 |
| Cavia | Deregulated Nutrient Sensing | The HMW-to-total ADPN ratio, a better predictor for insulin resistance, was significantly and positively correlated with PWV (r = 0.34, p < 0.01) and CAVI (r = 0.24, p = 0.05). | 18493156 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion, peripheral insulin resistance, and increased hepatic glucose production. | 18496642 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | IGFBP-1 increased 32% (95% CI 17-49%) during the 10 years in those developing diabetes and was increased in relation to insulin levels, suggesting the emergence of hepatic insulin resistance. | 18496669 |
| Dyslipidemias, Spinal Fractures | Deregulated Nutrient Sensing | By logistic regression analysis with multivariate adjustment, age (P < 0.01), dyslipidemia (P < 0.05), and the presence of vertebral fracture (P < 0.05) were independent risk factors for echogenic carotid plaques. | 18496724 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relation among left ventricular mass, insulin resistance, and hemodynamic parameters in type 2 diabetes. | 18497461 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. | 18501007 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrome patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function. | 18501898 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | There was a significant insulin resistance in PCOS patients. | 18501898 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Existence of insulin resistance alone may not be an adequate factor for deterioration of endothelial function and carotid IMT in young, nonobese patients with PCOS. | 18501898 |
| Obesity | Deregulated Nutrient Sensing | Other factors such as duration of insulin resistance, older age, presence of obesity, and inflammatory markers may play an important role in this process. | 18501898 |
| Dyslipidemias | Deregulated Nutrient Sensing | Uraemic dyslipidaemia, which is characterized by low HDL-cholesterol (HDL-C) and elevated triglycerides' levels, may contribute to this elevated cardiovascular risk. | 18503096 |
| Dyslipidemias, Chronic rejection of renal transplant | Deregulated Nutrient Sensing | Clinical correlation between dyslipidemia and pediatric chronic allograft nephropathy. | 18503482 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | This study provides suggestive evidence that treatment with ezetimibe plus low-dose simvastatin is well tolerated by HT recipients and may be effective for treatment of dyslipidemia in HT recipients with statins intolerance or resistance. | 18503971 |
| Obesity | Deregulated Nutrient Sensing | Impaired endothelial function in obesity may reduce blood flow to sites of metabolism, contributing to impaired fat oxidation and insulin resistance. | 18504447 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The prevalence of hypertension, impaired glucose metabolism, dyslipidemia, and obesity was 45%, 65%, 65%, and 25%, respectively. | 18506093 |
| Dyslipidemias, Overweight, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | High prevalence factors for cardiovascular risk were observed, such as: overweight and obesity, hypertension, dyslipidemia, sedentariness and inadequate diet. | 18506342 |
| Dyslipidemias, Alagille Syndrome | Deregulated Nutrient Sensing | Dyslipidemia does not seem to be a phenotypic expression in first degree relatives of children with Alagille syndrome. | 18507066 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The interaction between impaired acute insulin response and insulin resistance predict type 2 diabetes and impairment of fasting glucose. | 18509807 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impaired acute insulin response (AIR) and insulin resistance (IR) are characteristics of Type 2 diabetes (T2DM). | 18509807 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4) has been found to induce insulin resistance and to be increased in type 2 diabetes. | 18514142 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, Insulin resistance syndrome | Deregulated Nutrient Sensing | The reduction of muscle mass may be responsible for reduced insulin sensitivity and decreased glucose uptake, thus increasing the risk for hyperglycemia and insulin-resistance syndrome in elderly subjects with type 2 diabetes mellitus. | 18514633 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To identify important factors that may contribute to abnormal glucose tolerance in elderly patients with treated hypertension with primary reference to changes in the following parameters: calculated insulin resistance, endogenous insulin processing and secretion; platelet cation concentration and membrane ATPase activity. | 18516349 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The derived measure of insulin resistance in the hypertensive patients showed a significant increase in the progression from NG to IGT and DM. | 18516349 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Our findings support the strong link between essential hypertension, insulin resistance/hyperinsulinaemia and regional adiposity. | 18516349 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is considered one of the main risk factors for cardiovascular disease (CVD), which is more frequent in older individuals. | 18516398 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | At 6-month follow-up, the patient continued to have elevated glycosylated hemoglobin, hypertension, dyslipidemia, and excess weight. | 18519838 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of leptin with insulin resistance, body composition, and lipid parameters in postmenopausal women and men in type 2 diabetes mellitus. | 18521457 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine the association of leptin with insulin resistance, body composition, and lipid parameters in postmenopausal women and men with type 2 diabetes mellitus (T2DM). | 18521457 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Type 2 diabetes mellitus seemed more effective on insulin resistance than obesity. | 18521457 |
| Proteinuria, Albuminuria, diabetic | Deregulated Nutrient Sensing | Diabetic patients with MVC and mvc had higher insulin resistance, higher plasmatic levels of total homocysteine and a higher incidence ofalbuminuria or proteinuria. | 18522290 |
| Glucose Intolerance (disease), Diabetes Mellitus, Blood Glucose | Deregulated Nutrient Sensing | There is a moderate prevalence of diabetes and a high prevalence of total disorders of glycemia, which suggests that this community, unlike other rural communities in Africa, is well into an epidemic of glucose intolerance. | 18523142 |
| Data types - Address | Deregulated Nutrient Sensing | We used experimental validation in addition to literature to reveal how the deregulated brain microRNAs are biomarkers for known and novel pathways in AD pathogenesis related to amyloid processing, neurogenesis, insulin resistance, and innate immunity. | 18525125 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The purpose of this study is to explore the attitudes that contribute to psychological insulin resistance (PIR) in insulin-naive patients with type 2 diabetes and to identify predictors of PIR. | 18535324 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | This process is dampened in patients with diabetes mellitus and dyslipidemia. | 18535371 |
| Pathology | Deregulated Nutrient Sensing | Modulation of SIRT1 expression in different neurodegenerative models and human pathologies. | 18538940 |
| Pathology | Deregulated Nutrient Sensing | We examined the expression of SIRT1 in several experimental paradigms of human pathologies. | 18538940 |
| Neurotoxicity Syndromes | Deregulated Nutrient Sensing | Subsequently, SIRT1 expression was compared in these different paradigms of neurotoxicity. | 18538940 |
| HD Term Type | Deregulated Nutrient Sensing | SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. | 18538940 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The emergence of type 2 diabetes in young populations has mirrored a rising prevalence of obesity and insulin resistance during childhood and adolescence. | 18539644 |
| Obesity | Deregulated Nutrient Sensing | At the same time, the role of adipokines as links between obesity and insulin resistance is becoming more appreciated. | 18539644 |
| metabolic disturbance | Deregulated Nutrient Sensing | The metabolic disturbances associated with insulin resistance appear to be more advanced in girls. | 18539644 |
| Inflammation, Congenital neurologic anomalies, Dyslipidemias, Coronary Arteriosclerosis, Renal Insufficiency, Hypertension, CTCAE | Deregulated Nutrient Sensing | In the general population, RVO is associated with hypertension, dyslipidemia, and renal dysfunction, but not with atherosclerotic disease, systemic inflammation, and hematologic abnormalities. | 18539932 |
| Weight Gain, Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The accelerator/beta-cell stress hypothesis regards insulin resistance as one common basis for type 1 and type 2 diabetes and weight increase as an important trigger of type 1 diabetes. | 18540867 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity-related cardiometabolic risk factors contribute to interindividual variation in REE, with hypertension and insulin resistance being associated with a higher REE. | 18541558 |
| Dyslipidemias, Aortic valve disorder | Deregulated Nutrient Sensing | These findings may have important implications for the efficacy of and targets for dyslipidemia therapies in calcific aortic valve disease. | 18541828 |
| Dyslipidemias, Hypertension, CTCAE, Alcoholic Intoxication, Chronic, Diabetes Mellitus | Deregulated Nutrient Sensing | The risk factors were: arterial hypertension, 40.3%; smoking, 32.7%; dyslipidemia, 16.0%; diabetes mellitus, 10.6%; alcoholism, 6.7%. | 18543194 |
| Dyslipidemias | Deregulated Nutrient Sensing | Although visceral adipose tissue (VAT) has been strongly linked with dyslipidemia, the importance of intermuscular adipose tissue (IMAT) to dyslipidemia and exercise responses is less well understood. | 18544640 |
| Dyslipidemias | Deregulated Nutrient Sensing | Reducing IMAT through aerobic exercise may be functionally related to some improvements in atherogenic dyslipidemia in men. | 18544640 |
| Adrenal Gland Hyperfunction | Deregulated Nutrient Sensing | Growth hormone (GH) deficiency and hypercortisolemia predispose to abdominal adiposity and insulin resistance, and GH secretion is decreased in obese adults. | 18544645 |
| Overweight | Deregulated Nutrient Sensing | We hypothesized that low-peak GH on the GH-releasing hormone (GHRH)-arginine stimulation test and high cortisol in overweight adolescents would be associated with higher regional fat, insulin resistance, and lipids. | 18544645 |
| Dyslipidemias | Deregulated Nutrient Sensing | This increased prevalence was due to dyslipidemias rather than higher blood pressure, glucose, or waist circumference. | 18545157 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | We have evaluated the use of the immunosuppressant mycophenolate mofetil (MMF) in the treatment of severe insulin resistance caused by neutralising anti-insulin antibodies in type 1 diabetes mellitus (T1DM). | 18547238 |
| Schizophrenia | Deregulated Nutrient Sensing | Prevalence of insulin resistance in schizophrenia in HUKM. | 18551931 |
| Microalbuminuria, Hypertriglyceridemia | Deregulated Nutrient Sensing | Insulin resistance is the major determinant for microalbuminuria in severe hypertriglyceridemia: implication for high-risk stratification. | 18552465 |
| Diabetes Mellitus, Non-Insulin-Dependent, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet. | 18555837 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Low birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome. | 18555843 |
| Peripheral Vascular Diseases, Inflammation | Deregulated Nutrient Sensing | Association of insulin resistance and inflammation with peripheral arterial disease: the National Health and Nutrition Examination Survey, 1999 to 2004. | 18559705 |
| Peripheral Vascular Diseases, Inflammation | Deregulated Nutrient Sensing | Although the role of inflammation in the pathophysiology of peripheral arterial disease (PAD) is well established, the contribution of insulin resistance (IR) to PAD is less clear. | 18559705 |
| Prostate Cancer Outcomes Study, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | PCOS cases exhibit an adverse coronary heart disease (CHD) profile at an early age, including insulin resistance, dyslipidemia and increased central adiposity. | 18561521 |
| Calcification of coronary artery, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Coronary artery calcification, ADMA, and insulin resistance in CKD patients. | 18562597 |
| SLC25A20 gene | Deregulated Nutrient Sensing | However, little information is available about any association between plasma levels of asymmetric dimethylarginine (ADMA), insulin resistance, and CAC. | 18562597 |
| Chronic kidney disease mineral and bone disorder, SLC25A20 gene | Deregulated Nutrient Sensing | CAC becomes more prevalent and severe with a decline in GFR, and plasma ADMA levels and insulin resistance, independent of factors associated with CKD-MBD, are correlated with CAC. | 18562597 |
| Hyperglycemia, Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is characterized by insulin resistance and hyperglycemia. | 18564365 |
| Malignant tumor of colon, Hypertriglyceridemia | Deregulated Nutrient Sensing | Epidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer. | 18565233 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Anemia, Obesity, Kidney Failure | Deregulated Nutrient Sensing | The prevalence of comorbidities was high: atrial fibrillation, 46%; diabetes, 38%; obesity, 64%; dyslipidemia, 60%; anemia, 27%; and renal failure, 7%. | 18570782 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Relationship between insulin resistance and serum alanine aminotransferase as a surrogate of NAFLD (nonalcoholic fatty liver disease) in obese Korean children. | 18571268 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | It has been known that nonalcoholic fatty liver disease (NAFLD) as one of obesity-related comorbidities is related with insulin resistance. | 18571268 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | So, we investigated the relation between insulin resistance and NAFLD, using serum alanine aminotransferase (ALT) as a surrogate of NAFLD among obese children in Korea. | 18571268 |
| Weight decreased, Dyslipidemias | Deregulated Nutrient Sensing | Weight loss in the CRD group led to improvements in both insulin sensitivity and dyslipidemia, but the change in the former was less than in RSG-treated patients, and improvement in lipid metabolism not as great as with FEN. | 18572037 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Safety and efficacy of simvastatin for the treatment of dyslipidemia in human immunodeficiency virus-infected patients receiving efavirenz-based highly active antiretroviral therapy. | 18576906 |
| Dyslipidemias | Deregulated Nutrient Sensing | These preliminary comparative data suggest that simvastatin can be safely and effectively used to treat dyslipidemia in HIV-infected patients receiving efavirenz-based HAART without compromising viral or immunologic control. | 18576906 |
| leukemia, Disease | Deregulated Nutrient Sensing | A similar prevalence has also been reported in older children evaluated echocardiographically for other diseases such as insulin-resistance and leukemia. | 18577303 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Treatment with pioglitazone increased plasma adiponectin levels and improved ED-FMD in patients with stable CAD and no evidence of diabetes or insulin resistance. | 18580598 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Significant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance. | 18581044 |
| Hypercholesterolemia, Cardiovascular Diseases | Deregulated Nutrient Sensing | It is supposed that the coexistence of higher insulin resistance and hypercholesterolemia for carriers of the D19H polymorphism may result in a greater risk of cardiovascular disease. | 18581044 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Clinical variables increasing the likelihood of full screening were clozapine treatment and a known diagnosis of diabetes or dyslipidaemia. | 18582345 |
| Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003-2004. | 18585505 |
| Dyslipidemias | Deregulated Nutrient Sensing | Improved treatment efforts to target the spectrum of dyslipidemia are needed. | 18585505 |
| Dyslipidemias, Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | Those in the weight-loss group were less likely to be in a race group at higher risk for obesity, have depression or dyslipidemia, or have taken >30 days of a sulfonylurea alone or with metformin. | 18587618 |
| Dyslipidemias | Deregulated Nutrient Sensing | Highly active antiviral therapy (HAART) results in a sharp decrease in HIV-related morbidity and mortality, but also induces adverse effects such as dyslipidemia, which is difficult treat because of drug interactions. | 18588813 |
| Dyslipidemias | Deregulated Nutrient Sensing | Rosuvastatin was safe and effective for treating dyslipidemia in HAART-treated HIV-infected patients. | 18588813 |
| Obesity, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance in patients with stroke is related to visceral fat obesity and adipocytokines. | 18589336 |
| Hyperglycemia, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is associated with hyperglycemia and dyslipidemia and promotes atherosclerosis. | 18589336 |
| Cerebrovascular accident, Diabetes Mellitus | Deregulated Nutrient Sensing | Although insulin resistance is associated with adipocytokines, little is known about the association in patients with stroke without diabetes mellitus. | 18589336 |
| Tumor necrosis | Deregulated Nutrient Sensing | We measured insulin resistance, the plasma level of tumor necrosis factor (TNF)-alpha, adiponectin, and the visceral fat area. | 18589336 |
| Increased insulin level | Deregulated Nutrient Sensing | In all, 21 of 60 patients (35.0%) had insulin resistance and 35 (58.3%) had hyperinsulinemia. | 18589336 |
| Cerebrovascular accident, Atherosclerosis | Deregulated Nutrient Sensing | We recommend that obese patients with stroke should be examined for insulin resistance to reduce the risk of the development of atherosclerosis. | 18589336 |
| Blood Glucose | Deregulated Nutrient Sensing | This prospective study reports inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance. | 18591391 |
| Lipodystrophy | Deregulated Nutrient Sensing | Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld mouse, and LPIN1 expression and common genetic variation were recently suggested to influence adiposity and insulin sensitivity in humans. | 18591397 |
| Lipodystrophy, Unknown (origin) (qualifier value) | Deregulated Nutrient Sensing | LPIN1 exons, exon/intron boundaries, and 3' untranslated region were sequenced in 158 patients with idiopathic severe insulin resistance (including 23 lipodystrophic patients) and 48 control subjects. | 18591397 |
| HIV Infections | Deregulated Nutrient Sensing | Insulin resistance in HIV infection: drugs, host responses, or restoration to health? | 18591716 |
| Hyperlipidemia | Deregulated Nutrient Sensing | Protease inhibitors (PIs) are widely assumed to be associated with a syndrome of insulin resistance accompanied by hyperlipidemia and fat redistribution. | 18591716 |
| HIV Infections | Deregulated Nutrient Sensing | This article summarizes a presentation on insulin resistance in HIV infection made by Carl Grunfeld, MD, PhD, at the 10th Annual Ryan White HIV/AIDS Program Clinical Update in Phoenix in June 2007. | 18591716 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | The findings provide important evidence concerning the hypertension as a public health problem and its association with dyslipidemia and abdominal obesity in the rural area of Minas Gerais. | 18592091 |
| Critical Illness | Deregulated Nutrient Sensing | Insulin resistance is common and often multifactorial in acutely critically ill patients. | 18595867 |
| Aortic Aneurysm, Thoracic | Deregulated Nutrient Sensing | The authors present a case in which a patient developed severe insulin resistance following surgical repair of a thoracic aorta aneurysm. | 18595867 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension was present in 1524 (78.1%) and dyslipidemia in 764 (39.1%). | 18596402 |
| Dyslipidemias | Deregulated Nutrient Sensing | The dyslipidaemia was equally severe in both genders. | 18599067 |
| Dyslipidemias, MS gene | Deregulated Nutrient Sensing | Excess risk for low HDL-C, dyslipidemia and MS is associated with the rare alleles of the APOA5 SNPs and non-carriers of common haplotype in women. | 18601598 |
| Atherosclerosis | Deregulated Nutrient Sensing | Before telmisartan therapy, low preheparin LpL mass concentration was closely associated with the pathogenesis of insulin resistance and the presence of coronary atherosclerosis. | 18603820 |
| Coronary heart disease | Deregulated Nutrient Sensing | Quality of life and insulin resistance in patients with coronary heart disease. | 18607164 |
| Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with coronary heart disease and without known diabetes mellitus an estimated measure of quality of life was significantly and independently associated with poor insulin resistance. | 18607164 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Using coding data from an electronic medical record to identify all adults with an underlying diagnosis of hyperlipidemia enrolled to this PBRN, children at risk for dyslipidemia were identified. | 18612063 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Among well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance. | 18612115 |
| ACACA wt Allele | Deregulated Nutrient Sensing | As rates of fatty acid oxidation can influence the ability of the heart to withstand an ischemic insult, we examined the expression of MCD, ACC, and AMPK in the newborn human heart. | 18614968 |
| ACACA wt Allele | Deregulated Nutrient Sensing | In contrast, a negative correlation in both ACC and AMPK expression and age was observed. | 18614968 |
| ACACA wt Allele | Deregulated Nutrient Sensing | This indicates that increased expression of MCD, and the decreased expression of ACC and AMPK are important regulators of the maturation of fatty acid oxidation in the newborn human heart. | 18614968 |
| Thrombosis, Hypertension, CTCAE, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Stroke patients in particular can benefit from pharmacotherapy for thrombosis, hypertension, and dyslipidemia but are at high risk for medication nonpersistence. | 18616796 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Eligible adults were aged > or =25, overweight or obese (BMI=25-45 kg/m2), and on medications for hypertension and/or dyslipidemia. | 18617080 |
| Increased insulin level, Colorectal Carcinoma | Deregulated Nutrient Sensing | Evidence implicating hyperinsulinemia and insulin resistance in the etiology of colorectal cancer suggests that a diet characterized by a high glycemic index and load may increase the risk of this disease, but previous studies have yielded inconsistent results. | 18618276 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The HIV patients had a greater prevalence of dyslipidemia, diabetes, and PAD, which was symptomatic in five of them and in one subject from the general population. | 18620492 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | Impaired restrictive pulmonary function has been reported to be associated with insulin resistance and metabolic abnormalities. | 18625672 |
| Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Recent studies suggest that mitochondrial dysfunction and impaired expression of genes involved in oxidative phosphorylation (OXPHOS) may play a key role in the pathogenesis of insulin resistance in aging and type 2 diabetes. | 18628517 |
| Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | However, the study does not support the hypothesis that muscle mitochondrial dysfunction per se is the underlying key metabolic defect that explains or precedes whole body insulin resistance in LBW subjects at risk for developing type 2 diabetes. | 18628517 |
| Dyslipidemias, Hypertension, CTCAE, Neuropathy | Deregulated Nutrient Sensing | Hypertension (73.1%), dyslipidemia (63.2%), and neuropathy (52.1%) were the most common co-morbidities. | 18632023 |
| Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | Telmisartan, an angiotensin II type 1 receptor blocker, improves coronary microcirculation and insulin resistance among essential hypertensive patients without left ventricular hypertrophy. | 18633172 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension and insulin resistance are associated with reduced coronary vasodilatory capacity, possibly caused by structural changes in the coronary resistance vessels. | 18633172 |
| Hypertensive (finding), Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | The goal of this study was to compare the effect of an angiotensin receptor blocker (ARB) with that of a calcium channel blocker (CCB) on coronary flow reserve and insulin resistance among essential hypertensive patients without left ventricular hypertrophy. | 18633172 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | In conclusion, this study demonstrates that antihypertensive therapy with telmisartan, but not nifedipine, has a beneficial effect on coronary microcirculation and insulin resistance among essential hypertensive patients. | 18633172 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | HOMA-estimated insulin resistance is associated with hypertension in Iranian diabetic and non-diabetic subjects. | 18633753 |
| Hyperglycemia, Critical Illness | Deregulated Nutrient Sensing | The cornerstone of hyperglycaemia in critically ill patients is insulin resistance and it remains refractory to intensive insulin protocols. | 18636232 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | We found several synergistic effects between the studied polymorphisms and classical risk factors such as hypertension, obesity, diabetes and dyslipidaemia: the presence of the DD genotype of ACE I/D (and also ACE11860 GG) increases the odds of developing CAD when associated to each one of these classical risk factors, particularly when considering the male and early onset CAD subgroup analysis; AGT235 TT also increases the CAD risk in the presence of hypertension and dyslipidaemia, and AT1R1166 interacts positively with hypertension, smoking and obesity. | 18637188 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer. | 18637271 |
| Prostate carcinoma | Deregulated Nutrient Sensing | EZH2 expression increases during prostate cancer progression, whereas BMI-1 and SIRT1 are not well investigated. | 18637271 |
| Malignant neoplasm of prostate | Deregulated Nutrient Sensing | Expression of EZH2, BMI-1, SIRT1, and the DNA methyltransferases DNMT1 and DNMT3B measured by qRT-PCR in 47 primary prostate cancers was compared to APC, ASC, GSTP1, RARB2, and RASSF1A hypermethylation and LINE-1 hypomethylation. | 18637271 |
| Malignant neoplasm of prostate | Deregulated Nutrient Sensing | SIRT1 appears to be generally increased in prostate cancers. | 18637271 |
| Dyslipidemias, Angina Pectoris, Congestive heart failure | Deregulated Nutrient Sensing | Patients in the SES group had more dyslipidemia, history of congestive heart failure, and ostial lesions; patients treated with PES had more previous coronary artery bypass surgery, unstable angina, and type C lesions. | 18638589 |
| Obesity | Deregulated Nutrient Sensing | Elevated serum retinol-binding protein (RBP) concentration has been associated with obesity and insulin resistance, but accompanying retinol values have not been reported. | 18641048 |
| Obesity | Deregulated Nutrient Sensing | Investigations into the role of RBP in obesity and insulin resistance should include retinol to facilitate the measurement of apo-RBP and retinol:RBP. | 18641048 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes was defined as FPG > or = 6.93 mmol/L; dyslipidemia was based on Adult Treatment Panel III and hypertension on Joint National Committee VI recommendations. | 18641193 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of at least 1 risk factor and at least 2 risk factors of the 3 major risk factors for cardiovascular disease (hypertension, dyslipidemia, and diabetes) was also evaluated. | 18641193 |
| Primary malignant neoplasm, Dyslipidemias | Deregulated Nutrient Sensing | Monitoring of the lipid profile should be considered in cancer patients receiving capecitabine, particularly those with a known diagnosis of dyslipidemia. | 18641989 |
| Dyslipidemias, Blood Coagulation Disorders, Inherited, Fatty Liver Disease | Deregulated Nutrient Sensing | Fatty liver disease is mainly caused by alcohol consumption, excessive body weight, dyslipidemia and impaired glucose tolerance, but inherited disorders can sometimes be involved. | 18644654 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Since the mortality rate due to cardiovascular disease continues to increase, research into dyslipidemia has been emphasized in not only adults but also paediatric populations. | 18647280 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | For each child, data were collected on body height (cm), body weight (kg), sitting height (cm), waist circumference, upper arm circumference, serum lipid levels, as well as familial history of dyslipidemia and early onset cardiovascular disease. | 18647280 |
| Dyslipidemias | Deregulated Nutrient Sensing | Logistic regression analysis suggested that WHR, diastolic blood pressure and positive familial history were risk factors for dyslipidemia in children. | 18647280 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | BMI, WHR, diastolic pressure and familial history of dyslipidemia and early-onset cardiovascular disease were risk factors for dyslipidemia in Chinese children. | 18647280 |
| Dyslipidemias, Fatty degeneration, Diabetes Mellitus, Obesity, Hyperuricemia, Overweight | Deregulated Nutrient Sensing | The prevalence of overweight, obesity, diabetes, dyslipidemia and hyperuricemia were also significantly higher in patients with steatosis than those without it (chi2 values 17.00, 169.45, 6.12, 116.67 and 76.34, all P less than 0.05). | 18647531 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians. | 18647954 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular system | Deregulated Nutrient Sensing | All women at high risk for cardiovascular death have accelerated telomere erosion, not caused by type 2 diabetes per se but likely linked to other risk factors, including dyslipidemia. | 18650367 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | There were significant interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension, corresponding relative excess risk due to interactions were 0.799 and 0.651, respectively. | 18654021 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Increased CRP was associated with hypertension, there were interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension in Mongolian people. | 18654021 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The objective of the study was to identify the prevalence of obesity and dyslipidaemia in primary care physicians. | 18664023 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In Mexico the prevalence of obesity and dyslipidaemia in primary care physicians was higher than expected. | 18664023 |
| Structure of posterior cerebral artery | Deregulated Nutrient Sensing | While in BPH serum resistin levels correlated with insulin resistance, inflammatory status and cortisol, in PCa positive correlation with F/T PSA ratio and cortisol was observed. | 18665756 |
| HD Term Type, Dyslipidemias, Vascular Diseases | Deregulated Nutrient Sensing | Plasma adiponectin and leptin are expected as contributors related to dyslipidemia, suggesting these may be targets of prevention of vascular diseases in maintenance HD patients. | 18670142 |
| Endothelial dysfunction, Postprandial hyperlactemia | Deregulated Nutrient Sensing | Insulin resistance is associated with postprandial hyperlipidemia and endothelial dysfunction. | 18670365 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Patients with metabolic syndrome, characterized by insulin resistance, are at increased cardiovascular risk. | 18670365 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The main associated diseases were hypertension, dyslipidemia, and diabetes. | 18672602 |
| Renal Insufficiency, Dyslipidemias | Deregulated Nutrient Sensing | Population pharmacokinetics of rosuvastatin: implications of renal impairment, race, and dyslipidaemia. | 18674408 |
| Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | A population pharmacokinetic analysis of rosuvastatin in healthy volunteers, subjects with dyslipidaemia, and renal failure patients was performed using non-linear mixed-effects modelling and a two-compartment pharmacokinetic model with simultaneous first- and zero-order absorption. | 18674408 |
| Dyslipidemias | Deregulated Nutrient Sensing | Rosuvastatin CL/F was reduced in subjects with dyslipidaemia, but it is important to realise that the safety/efficacy profile of rosuvastatin has been well established in this population. | 18674408 |
| CD55 gene, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | This analysis explores what proportion of the UK population with cardiovascular disease (CVD) and TC levels at or below target may still be at risk because of residual dyslipidaemia. | 18674409 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with diabetes were more likely than non-diabetics to have abnormalities of both HDL-C (28.9 vs. 16.4%; p<0.0001) and triglyceride (44.9 vs. 29.5%; p<0.0001) despite normal TC and LDL-C. Around 60% of high-risk patients have residual dyslipidaemias despite achieving the Quality and Outcomes Framework (QOF) TC target. | 18674409 |
| Neurologic Deficits, Stanford Cancer Institute, Diabetes Mellitus | Deregulated Nutrient Sensing | Neurologic deficit combined with increased insulin resistance has a greater macrovascular impact on SCI veterans than on those who do not have diabetes. | 18674979 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is common in patients with chronic kidney disease. | 18676075 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | In hypertensive patients with moderate dyslipidemia and decreased eGFR, pravastatin was not superior to usual care in preventing clinical renal outcomes. | 18676075 |
| Hyperlipidemia, metabolic disturbance | Deregulated Nutrient Sensing | Both conditions can be very disturbing to patients and have been associated with metabolic disturbances such as insulin resistance and hyperlipidemias. | 18677013 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Efficacy and safety of a potent and selective peroxisome proliferator activated receptor alpha agonist in subjects with dyslipidemia and type 2 diabetes mellitus. | 18678301 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This randomized, multicenter, double-blinded, placebo-controlled study evaluated the efficacy and safety of CP-778,875 in subjects with mixed dyslipidemia and type 2 diabetes. | 18678301 |
| Amyotrophic Lateral Sclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Our findings indicate that statins treatment for dyslipidemia in patients with ALS does not carry any survival risks. | 18678378 |
| Overweight | Deregulated Nutrient Sensing | Estimating insulin resistance may inform dietary recommendations for overweight children. | 18678809 |
| HPT gene | Deregulated Nutrient Sensing | In this sample of originally normotensive men, circulating LPT level was a significant predictor of the risk to develop HPT over 8 yr, independently of BMI and insulin resistance. | 18682500 |
| Polycystic Ovary Syndrome, Ventricular Dysfunction, Left | Deregulated Nutrient Sensing | Subclinical impairment of left ventricular function in young obese women: contributions of polycystic ovary disease and insulin resistance. | 18682502 |
| Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance (IR) may produce disturbances of left ventricular (LV) function. | 18682502 |
| Apolipoproteins B, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Apolipoprotein B and insulin resistance are good markers of carotid atherosclerosis in patients with type 2 diabetes mellitus. | 18684539 |
| Carotid Atherosclerosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this study, we investigated that Apo B concentrations and insulin resistance (HOMA-R) can be good markers of carotid atherosclerosis in patients with type 2 diabetes. | 18684539 |
| Cessation of life, Dyslipidemias | Deregulated Nutrient Sensing | The 2006 Canadian dyslipidemia guidelines will prevent more deaths while treating fewer people--but should they be further modified? | 18685741 |
| Cessation of life, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | To compare the effectiveness and efficiency of the 2003 and 2006 Canadian dyslipidemia guidelines for statin treatment in reducing deaths from coronary artery disease (CAD) in the Canadian population. | 18685741 |
| Cessation of life, Dyslipidemias | Deregulated Nutrient Sensing | From a population perspective, the 2006 Canadian dyslipidemia recommendations are an improvement of earlier versions, preventing more CAD events and deaths with fewer statin prescriptions. | 18685741 |
| Critical Illness | Deregulated Nutrient Sensing | To observe the changes in blood glucose, serum insulin level and insulin resistance of critically ill patients during the acute stage and explore the relationship between the changes and their prognosis. | 18687177 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pattern of dyslipidaemia among Nigerians with type 2 diabetes mellitus. | 18689135 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia is common among patients with type 2 diabetes mellitus in Nigeria with majority of the patients having a combined dyslipidaemia. | 18689135 |
| Increased insulin level, Pancreatic carcinoma, Hyperglycemia | Deregulated Nutrient Sensing | Although it has been hypothesized that hyperglycemia, hyperinsulinemia, and insulin resistance are involved in the development of pancreatic cancer, results from epidemiologic studies of added sugar intake are inconclusive. | 18689380 |
| Dyslipidemias, Thrombocytopenia | Deregulated Nutrient Sensing | Danazol was resumed to treat persistent thrombocytopenia, while lovastatin was replaced with ezetimibe 10 mg QD to treat high cholesterol (dyslipidemia). | 18691993 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population. | 18692268 |
| Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The sterol regulatory element-binding protein (SREBP)-1c gene has been identified as a susceptibility gene in metabolic diseases such as type 2 diabetes mellitus (T2DM), obesity, dyslipidemia and insulin resistance. | 18692268 |
| diabetic | Deregulated Nutrient Sensing | Moreover, the SNP (rs11868035) is closely related to insulin resistance (IR) in diabetic patients. | 18692268 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings indicate that the SREBP-1c SNPs rs2297508 and rs11868035 are associated with a significantly increased risk of T2DM and dyslipidemia in the Chinese population. | 18692268 |
| Hypertensive (finding), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The angiotensin II receptor blocker telmisartan improves insulin resistance and has beneficial effects in hypertensive patients with type 2 diabetes and poor glycemic control. | 18692932 |
| Hypertensive (finding), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results indicate that telmisartan improves insulin resistance and gives beneficial effects in hypertensive patients with type 2 diabetes and a poor glycemic control. | 18692932 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | We collected data on smoking, diabetes, hypertension, dyslipidemia, and cardiovascular disease history. | 18692981 |
| Overweight | Deregulated Nutrient Sensing | Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren. | 18693476 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, a notable increase in the risk of insulin resistance and type 2 diabetes mellitus has emerged. | 18693476 |
| Overweight | Deregulated Nutrient Sensing | To determine the prevalence of insulin resistance and impaired glucose tolerance in overweight and obese schoolchildren. | 18693476 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of impaired glucose tolerance and insulin resistance in obese children indicates a worrisome trend in the incidence of type 2 diabetes in Costa Rica. | 18693476 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is a major risk factor of cardiovascular disease in patients on maintenance haemodialysis. | 18693593 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Obesity represents a risk factor for insulin resistance, type 2 diabetes mellitus, and atherosclerosis. | 18695074 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | A metabolically benign obesity that is not accompanied by insulin resistance and early atherosclerosis exists in humans. | 18695074 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The coronary artery disease (CAD) risk factors were smoking (66%), hypertension (41%), diabetes mellitus (44%), and dyslipidemia (46%). | 18697380 |
| Hypertension, CTCAE, Blood Glucose | Deregulated Nutrient Sensing | A prospective study of glycemia, body size, insulin resistance and the risk of hypertension in Mauritius. | 18698207 |
| Haplotypes, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, the 1221/1121 haplogenotype is under-represented in individuals that fulfil the International Diabetes Federation (IDF) diagnostic criteria for MS. Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population. | 18698425 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | The second objective was determining the relation of acanthosis nigricans and insulin-resistance. | 18700035 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | No statistical significance was found between the presence of acanthosis nigricans and insulin resistance. | 18700035 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence. | 18700035 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia is one of the major risk factors of coronary artery disease. | 18700621 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream. | 18700811 |
| Blood Glucose, Diabetes Mellitus | Deregulated Nutrient Sensing | Observed associations between serum CRP and insulin resistance, glycemia, and diabetes are likely to be noncausal. | 18700811 |
| Cardiovascular Diseases, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary heart disease, Heart failure, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Patients with CKD were significantly more likely to be older, to have atherogenic dyslipidemia and a history of cardiovascular diseases (coronary heart disease, prior myocardial infarction, heart failure) (p < 0.01). | 18702327 |
| Diabetes Mellitus, Non-Insulin-Dependent, metabolic disturbance, Obesity | Deregulated Nutrient Sensing | Individuals with obesity and/or metabolic disturbances (insulin resistance and type 2 diabetes) have increased plasma ASP. | 18702682 |
| Obesity | Deregulated Nutrient Sensing | In addition, exercise participation, even in the absence of difference in physical fitness, may be protective against development of central obesity and insulin resistance in this understudied Korean population. | 18702942 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | These data suggest that fetuin-A might be a regulator of insulin resistance and/or metabolic syndrome. | 18702951 |
| Hypertension, CTCAE, Kidney Diseases | Deregulated Nutrient Sensing | Is there a link between insulin resistance and chronic kidney disease in men with treated hypertension? | 18703873 |
| Cachexia | Deregulated Nutrient Sensing | The current findings indicated that subcutaneous WAT does not contribute to the systemic inflammatory reaction and does not induce adipocyte insulin resistance in cancer cachexia. | 18704987 |
| Haploinsufficiency | Deregulated Nutrient Sensing | Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. | 18708577 |
| Malignant neoplasm of prostate | Deregulated Nutrient Sensing | We report here that Rheb GTPase, the upstream activator of the mTOR complex 1 (mTORC1) is amplified in human prostate cancers. | 18708577 |
| Aggressive Non-Hodgkin Lymphoma | Deregulated Nutrient Sensing | We find that Rheb, a proximal activator of mTORC1, can produce rapid development of aggressive and drug-resistant lymphomas. | 18708578 |
| Lymphoma | Deregulated Nutrient Sensing | Notably, RHEB is highly expressed in some human lymphomas, resulting in mTORC1 activation and increased sensitivity to rapamycin and FTI. | 18708578 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | In summary, the Rheb GTPase is an oncogenic activity upstream of mTORC1 and eIF4E and a direct therapeutic target of farnesyltransferase inhibitors in cancer. | 18708578 |
| Proteinuria, Kidney Failure, Chronic, Dyslipidemias, Anemia, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Timely recognition of risk factors for CKD progression and their treatment by correction of high blood pressure, reduction of proteinuria, correction of anaemia and dyslipidaemia (to lower cardiovascular risk) may retard progression of CKD to end-stage renal disease, thus delaying the need for renal replacement therapy. | 18709007 |
| Obesity, Dyslipidemias, Chronic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | These changes can induce a significant increase in the prevalence of some chronic diseases, such as obesity, dyslipidemia, and diabetes mellitus. | 18710332 |
| Atherosclerosis | Deregulated Nutrient Sensing | SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis. | 18710632 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction. | 18712517 |
| Dyslipidemias | Deregulated Nutrient Sensing | PPARG mutations may cause insulin resistance and dyslipidemia, but little is known about the mechanisms of the abnormalities of lipid metabolism. | 18713822 |
| Prediabetes syndrome, Insulin Secretion, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Using our thoroughly phenotyped cohort of subjects at an increased risk for type 2 diabetes, we assessed the association of the nine latest genetic variants with the predominant prediabetes traits, i.e., obesity, impaired insulin secretion, and insulin resistance. | 18714373 |
| Malignant neoplasm of skin | Deregulated Nutrient Sensing | Collectively, we conclude that AMPK contributes to UV- and H(2)O(2)-induced apoptosis via multiple mechanisms in human skin keratinocytes and AMPK plays important roles in UV-induced signal transduction ultimately leading to skin photoaging and even skin cancer. | 18715874 |
| Inflammation, Cachexia, Anorexia | Deregulated Nutrient Sensing | Anorexia, inflammation, insulin resistance and increased muscle protein breakdown are frequently associated with cachexia. | 18718696 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | If an individual was diagnosed with diabetes, hypertension, or dyslipidemia, each item was recorded as a positive finding. | 18719340 |
| Liver Dysfunction | Deregulated Nutrient Sensing | Common SNPs in ADIPOR2 are associated with LFT in T2DM subjects, which suggests a possible role of this receptor in liver dysfunction associated with insulin resistance. | 18719649 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was strong association between diabetes mellitus and dyslipidaemia (P < 0.05). | 18720629 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In regression analysis, diabetes was the second most important factor after obesity in secondary dyslipidaemia. | 18720629 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Recently, we found that soluble CD36 is increased in plasma from patients with diabetes strongly correlated with insulin resistance. | 18723424 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. | 18752331 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Alterations in glucose metabolism and insulin resistance in subjects with normal ALT should also be considered in the selection of NAFLD cases for histological assessment of disease severity and progression. | 18752331 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study demonstrates that 48 hours of bed rest has no significant effect on insulin resistance or standard metabolic variables in normal subjects and patients with type 2 diabetes. | 18753098 |
| Platelet Glycoprotein IV Deficiency, Hypertriglyceridemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with CD36 deficiency (CD36-D) have postprandial hypertriglyceridemia, insulin resistance, and hypertension. | 18753675 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | For patients with T1DM, being overweight was associated with higher blood pressure and dyslipidemia. | 18753706 |
| Hypertriglyceridemia, Dyslipidemias, Hypercholesterolemia, Familial | Deregulated Nutrient Sensing | The prevalences of hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, impaired glucose tolerance (IGT), and WCH were similar to excess weight in that they increased significantly until the seventh decade of life and decreased thereafter significantly (P < 0.05 in most steps). | 18753728 |
| Demographics Domain, Hypertriglyceridemia, Dyslipidemias, Haiti, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE, Hypercholesterolemia, Familial | Deregulated Nutrient Sensing | On the other hand, the prevalences of hypertension (HT), diabetes mellitus (DM), and coronary heart disease (CHD) always increased significantly with age without any decrease (P < 0.05 in most steps), indicating their irreversibility in contrast to the reversibility of excess weight, hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, IGT, and WCH. | 18753728 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | C-reactive protein, insulin resistance and risk of cardiovascular disease: a population-based study. | 18753952 |
| Inflammation, Metabolic Diseases | Deregulated Nutrient Sensing | C-reactive protein (CRP), a marker of inflammation, and insulin resistance (IR), a metabolic disorder, are closely related. | 18753952 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity in males and insulin resistance in females were prevalent in children who were at elementary school level. | 18756035 |
| Biliary calculi | Deregulated Nutrient Sensing | Insulin resistance is associated with gallstones even in non-obese, non-diabetic Korean men. | 18756051 |
| Biliary calculi, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | It remains unclear as to whether insulin resistance alone or in the presence of wellknown risk factors, such as diabetes or obesity, is associated with gallstones in men. | 18756051 |
| Cholelithiasis, Obesity | Deregulated Nutrient Sensing | The aim of this study was to determine whether insulin resistance is associated independently with gallstone disease in non-diabetic men, regardless of obesity. | 18756051 |
| Biliary calculi, Obesity | Deregulated Nutrient Sensing | Insulin resistance was positively associated with gallstones in non-diabetic Korean men, and this occurred regardless of obesity. | 18756051 |
| Biliary calculi | Deregulated Nutrient Sensing | Gallstones appear to be a marker for insulin resistance, even in non-diabetic, nonobese men. | 18756051 |
| Dyslipidemias, atherosclerotic, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Although previous studies suggest that treatment of dyslipidemia with statins reduces mortality and morbidity that are associated with cardiovascular disease, only a few studies have examined the efficacy of statins on atherosclerotic status in patients with chronic kidney disease (CKD). | 18758125 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Identifying health-related quality of life (HRQL) domains for multiple chronic conditions (diabetes, hypertension and dyslipidemia): patient and provider perspectives. | 18759755 |
| methyldopa, Inflammation, Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | This finding may suggest that pathogenic processes linking to wider venular caliber be shared by early AMD and common cardiovascular risk factors such as inflammation, dyslipidemia, and endothelial dysfunction. | 18760764 |
| diabetic | Deregulated Nutrient Sensing | In subgroup analysis, Japanese obese diabetic -2518AA carriers had a higher MCP-1 concentration and increased insulin resistance than obese diabetic -2518G carriers. | 18762729 |
| Cardiomyopathy, Familial Idiopathic, Myocardial | Deregulated Nutrient Sensing | Trimetazidine improved whole-body insulin sensitivity and glucose control in these insulin-resistant idiopathic dilated cardiomyopathy patients, thus hypothetically countering the myocardial damage of insulin resistance. | 18765391 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Prevalence and particularities of dyslipidaemia in subjects with coronary heart disease. | 18767409 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The purpose of the study was to evaluate the lipid profile and the prevalence of dyslipidaemia and other risk factors in subjects with and without coronary heart disease. | 18767409 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidaemia was higher in group 1 than in group 2 (91.2% vs. 85.3%; p = 0.01). | 18767409 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The study found a high prevalence of dyslipidaemia in Romanian patients with coronary heart disease. | 18767409 |
| Weight decreased, Increased insulin level, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | We also observed marked weight loss and resolution of hypertension, dyslipidemia and hyperinsulinemia. | 18769731 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Known risk factors like dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile. | 18769801 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | The results do not support beneficial effects of CLA/n-3 LC-PUFA for beta-cell dysfunction or insulin resistance in humans but suggest that insulin sensitivity in older obese subjects is reduced. | 18772894 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia, especially low HDL cholesterol, in Iranian adults is very high. | 18774906 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated C-reactive protein (CRP), IL-6 and retinol-binding protein 4 (RBP4) levels are associated with insulin resistance and diabetes mellitus. | 18775100 |
| Diabetic Ketoacidosis | Deregulated Nutrient Sensing | that culminated in emergency treatment for diabetic ketoacidosis secondary to severe insulin resistance. | 18775978 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of type 2 diabetes and glucose intolerance was 5.55- and 1.90-fold higher, respectively, in Uygur than in the Kazak population (8.16 vs. 1.47%, P < 0.001 and 3.29 vs. 1.73%, P < 0.001). | 18777166 |
| Chronic heart failure | Deregulated Nutrient Sensing | Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition. | 18778861 |
| Chronic heart failure, Congestive heart failure | Deregulated Nutrient Sensing | In chronic heart failure (CHF) skeletal muscle insulin resistance occurs independently of etiology and contributes to impaired energy metabolism. | 18778861 |
| Congestive heart failure | Deregulated Nutrient Sensing | Low skeletal muscle GLUT4 contributes to insulin resistance in CHF. | 18778861 |
| Obesity | Deregulated Nutrient Sensing | Fructose-1,6-bisphosphatase (FBPase) is a regulated enzyme in gluconeogenesis that is increased in animal models of obesity and insulin resistance. | 18780768 |
| Diabetes Mellitus, Breast Carcinoma, Cardiovascular Diseases | Deregulated Nutrient Sensing | In postmenopausal women, an increase in insulin resistance is associated with an increased risk of diabetes, cardiovascular disease and breast cancer. | 18781481 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Hormone replacement therapy (HRT) can reduce insulin resistance and coffee use is reported to decrease the incidence of diabetes. | 18781481 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance is directly related to body mass index (p < 0.0001), and not with age and blood pressure; hypertensive menopausal women have a slightly higher body mass index but the same degree of insulin resistance as normotensive women. | 18781481 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Women on HRT show lower insulin resistance, but not lower prevalence of arterial hypertension. | 18781481 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | SHP mutations may also be associated with later obesity and insulin resistance syndrome that induces diabetes. | 18781616 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine how serum concentrations of resistin are distributed in humans in relation to insulin resistance, type 2 diabetes, and obesity. | 18789551 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | In this population resistin is inversely associated with insulin resistance and abdominal obesity. | 18789551 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | PEDF may play a protective role against hepatic insulin resistance in diabetes. | 18792873 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is characterized by a combination of insulin resistance, dyslipidemia, and increased blood pressure. | 18793563 |
| Migraine Disorders, Dyslipidemias, Diabetes Mellitus, pyruvate synthase activity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The observed lack of association between PFO and migraine (with or without aura) was not modified by diabetes mellitus, hypertension, cigarette smoking, or dyslipidemia. | 18794393 |
| Immunologic Deficiency Syndromes, HIV-1 Infection Pathway | Deregulated Nutrient Sensing | Kwon et al studying HIV-1 infection and subsequent immune deficiency process demonstrated that HIV-1 Tat protein binds to SIRT1 protein, a well-known longevity factor, and inhibits the SIRT1-mediated deacetylation of the p65 component of the NF-kappaB complex. | 18800364 |
| Longevity | Deregulated Nutrient Sensing | Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF-kappaB signaling, the major outcome of which is inflamm-aging via proinflammatory responses. | 18800364 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Clinical measures of physical fitness predict insulin resistance in people at risk for diabetes. | 18801854 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Clinical measures of physical fitness can predict insulin resistance in people at risk for diabetes. | 18801854 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The findings support the validity of clinical measures of physical fitness for predicting insulin resistance in people at risk for diabetes. | 18801854 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Accumulating evidence suggests that insufficient oxidative capacity plays a central role in the development of insulin resistance and, perhaps, hypertension. | 18802433 |
| Hyperthyroidism | Deregulated Nutrient Sensing | Plasma visfatin levels were not associated with indicators of insulin resistance in hyperthyroid patients. | 18803942 |
| Bronchopulmonary Dysplasia, Obesity | Deregulated Nutrient Sensing | Biliopancreatic diversion (BPD) is a surgical procedure performed in patients with untreatable obesity and insulin resistance. | 18803943 |
| Hypertensive (finding), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance. | 18803955 |
| Hypertensive (finding), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Telmisartan decreased body weight while increasing serum adiponectin levels in hypertensive patients with glucose intolerance. | 18803955 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone is a peroxisome proliferator-activated receptor-gamma agonist that decreases insulin resistance in type 2 diabetes mellitus. | 18803990 |
| Inflammation, Hypertriglyceridemia | Deregulated Nutrient Sensing | These data confirm impaired metabolism of fat among smokers and suggest that mechanisms other than inflammation or insulin resistance may explain the observed hypertriglyceridemia among smokers. | 18804210 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A family history of type 2 diabetes is associated with glucose intolerance and obesity-related traits with evidence of excess maternal transmission for obesity-related traits in a South East Asian population. | 18804306 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | T2DM appears to be heritable in South East Asians with excess maternal transmission of obesity, IR and dyslipidemia. | 18804306 |
| Retroviridae Infections, Pancreatitis, Dyslipidemias, Biliary calculi | Deregulated Nutrient Sensing | Episodes of pancreatitis were associated with alcohol consumption in 62% of cases and with gallstones in 14%; 4% of cases were associated with both gallstones and alcohol consumption, 8% with dyslipidaemia and 5% with retroviral disease. | 18807304 |
| Vascular Diseases, Dyslipidemias, Coronary Artery Disease, Cerebrovascular accident | Deregulated Nutrient Sensing | Vascular disease remains the prime contributor to the pathogenesis of stroke, but dyslipidemia has not been clearly established as a risk factor for stroke the same way it has been for coronary artery disease. | 18807425 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | There was a significant interaction between age and WC indicating that the relation between WC with insulin resistance, high CRP, and hypertension was attenuated in older adults. | 18809302 |
| Atherosclerosis, diabetic | Deregulated Nutrient Sensing | Measures of cardiovascular risk, body composition, and serum hormones from the baseline examinations of the Insulin Resistance Atherosclerosis Study on 524 nondiabetic women, 258 diabetic women, 421 nondiabetic men, and 220 diabetic men were compared to detect greater adverse differences in women than in men. | 18809621 |
| Injury of liver, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study. | 18813860 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. | 18813860 |
| Liver diseases, Ancriviroc, Non-alcoholic Fatty Liver Disease, Obesity, Disease | Deregulated Nutrient Sensing | We analyzed the incidence of obesity, insulin resistance, and other disorders in patients with NAFLD (Group A), CH-C (Group B), or other liver diseases (Group C). | 18813860 |
| Troponin I Type 2 Measurement | Deregulated Nutrient Sensing | Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass? | 18815486 |
| Atrophic, Troponin I Type 2 Measurement | Deregulated Nutrient Sensing | Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle. | 18815486 |
| Obesity | Deregulated Nutrient Sensing | These alterations in the 24-hour circadian patterns of BP were related to the degree of obesity and insulin resistance. | 18816210 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | 78.4% of the patients had dyslipidemia and 32.3% diabetes. | 18817699 |
| Obesity | Deregulated Nutrient Sensing | Patients with poorly compensated type 2 DM (HbAc1 > 7%) and DSF were given IIT corrected with regard for obesity and insulin resistance (IR). | 18819351 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | But the risk of MI increases with age, smoking, hypertension, dyslipidemia and diabetes. | 18819701 |
| Triglycerides | Deregulated Nutrient Sensing | Higher levels of sICAM-1 were independently associated with higher BMI, higher triglycerides, and lower insulin resistance (P < 0.001). | 18820652 |
| Alcoholic Intoxication, Chronic, Dyslipidemias, Myocardial Infarction, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Nineteen (48.5%) patients had hypertension, eight (20.5%) had history of smoking, six (15.5%) had history of alcoholism, eight (20.5%) had dyslipidemia, two (5.0%) had diabetes and one (2.56%) had myocardial infarct previously. | 18820790 |
| Coronary heart disease | Deregulated Nutrient Sensing | [Relation of phlegm-stasis syndrome with insulin resistance and monocyte PPARgamma mRNA expression in patients with coronary heart disease]. | 18822908 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To explore the relation of phlegm-stasis syndrome with insulin resistance and monocyte peroxisome proliferator activated receptor-gamma messenger ribonucleic acid (PPARgamma mRNA) expression in patients with coronary heart disease (CHD). | 18822908 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Changes of insulin resistance and PPARgamma mRNA expression in monocytes are possibly one of the mechanisms for the development of phlegm-stasis syndrome in CHD. | 18822908 |
| Inflammation | Deregulated Nutrient Sensing | Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women. | 18825363 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity. | 18826227 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone versus rosiglitazone treatment in patients with type 2 diabetes and dyslipidemia: cost-effectiveness in the US. | 18826750 |
| Dyslipidemias | Deregulated Nutrient Sensing | Baseline parameters came from a multi-center, double-blind trial comparing lipid and glycemic effects of pioglitazone (n = 400) and rosiglitazone (n = 402) among individuals with T2DM and untreated dyslipidemia. | 18826750 |
| Dyslipidemias | Deregulated Nutrient Sensing | Nevertheless, pioglitazone (when compared to rosiglitazone) was found to have long-term value as a treatment option for T2DM patients with dyslipidemia treated within the US payer setting. | 18826750 |
| Hyperinsulinism | Deregulated Nutrient Sensing | It is not known whether there is also a sex difference in the association between hyperinsulinaemia, reflecting insulin resistance, and CVD. | 18829029 |
| Hyperinsulinism, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | In parallel with diabetes, fasting hyperinsulinaemia reflecting insulin resistance in non-diabetic subjects is associated with an increased risk for cardiovascular disease, which is more pronounced in women than in men. | 18829029 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Although the former was only influenced by age, dyslipidaemia and diabetes mellitus influenced the latter. | 18830251 |
| Hyperuricemia, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, dyslipidaemia, hyperuricaemia and diabetes associated with higher OR for hypertension in Minnan women. | 18830252 |
| Glucose Intolerance (disease), Sleep disturbances | Deregulated Nutrient Sensing | Liver fat, visceral adiposity, and sleep disturbances contribute to the development of insulin resistance and glucose intolerance in nondiabetic dialysis patients. | 18832089 |
| Increased insulin level, IGHD1-7 gene | Deregulated Nutrient Sensing | DM1 predisposes insulin resistance and compensatory hyperinsulinemia exist even in patients with low FBS. | 18834994 |
| Glucose Intolerance (disease), Myotonic Dystrophy | Deregulated Nutrient Sensing | A cross-sectional study for glucose intolerance of myotonic dystrophy. | 18834994 |
| Glucose Intolerance (disease), IGHD1-7 gene | Deregulated Nutrient Sensing | We should pay attention to glucose intolerance of DM1 patients earlier than that of the general population. | 18834994 |
| Neoplasms | Deregulated Nutrient Sensing | We demonstrate that Sirt1(+/-);p53(+/-) mice develop tumors in multiple tissues, whereas activation of SIRT1 by resveratrol treatment reduces tumorigenesis. | 18835033 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Finally, we show that many human cancers exhibit reduced levels of SIRT1 compared to normal controls. | 18835033 |
| Neoplasms | Deregulated Nutrient Sensing | Thus, SIRT1 may act as a tumor suppressor through its role in DNA damage response and genome integrity. | 18835033 |
| Refractory anemias, Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia has been described in non-treated rheumatoid arthritis (RA), and improves after therapy with disease modifying anti-rheumatic drugs or glucocorticoids; however, it has generally been perceived that glucocorticoids adversely affect lipid metabolism. | 18837746 |
| Cardiac complication, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Central fat mass (CFM) correlates with insulin resistance and increases the risk of type 2 diabetes and cardiovascular complications. | 18838980 |
| Atherosclerosis, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary heart disease, Cerebral Atherosclerosis, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Patients with CKD were significantly more likely to be older, to have atherogenic dyslipidemia and clinical manifestations of atherosclerosis (coronary heart disease, prior myocardial infarction and cerebral atherosclerosis). | 18839606 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The aim of our study was to investigate the role of dyslipidemia on red blood cell sodium-lithium countertransport activity in healthy and hypertensive individuals. | 18840623 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Our results suggest that dyslipidemia affects sodium-lithium countertransport activity independently of essential hypertension and even to a greater extent than hypertension. | 18840623 |
| Glucose Intolerance (disease), Kidney Failure | Deregulated Nutrient Sensing | No adverse effects, such as renal failure or glucose intolerance, were seen. | 18845408 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Obesity could also directly and positively affect blood pressure (B = 0.51, P < 0.001), without the mediation of insulin resistance and/or inflammation. | 18846046 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Pre-Eclampsia | Deregulated Nutrient Sensing | These results suggest that insulin resistance and relative glucose intolerance are associated with an increased risk of new-onset hypertension in pregnancy, particularly preeclampsia, and support the hypothesis that insulin resistance may play a role in the pathogenesis of this disorder. | 18847384 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Transient hypertension of pregnancy, the new-onset nonproteinuric hypertension of late pregnancy, is associated with a high risk of later essential hypertension and glucose intolerance; thus, these conditions may have a similar pathophysiology. | 18847384 |
| Obesity | Deregulated Nutrient Sensing | To study insulin resistance and parental obesity as predictors of improvement in weight status in obese children and adolescents undergoing therapeutic life change intervention (TLC). | 18848671 |
| Failed | Deregulated Nutrient Sensing | Failing to respond to standard therapeutic lifestyle change intervention was dependent on baseline insulin resistance, and parental obesity-related comorbidity. | 18848671 |
| Fatty Liver, Obesity | Deregulated Nutrient Sensing | Liver biopsy of the apoB-13.7 heterozygote, which had obesity and insulin resistance, showed severe fatty liver. | 18848826 |
| glucose metabolism | Deregulated Nutrient Sensing | Preoperative administration of oral carbohydrate-rich solutions: Comparison of glucometabolic responses and tolerability between patients with and without insulin resistance. | 18849145 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, our data indicate that RBP4 levels in plasma, skeletal muscle, and fat may be linked to insulin resistance and type 2 diabetes in a secondary and noncausal manner. | 18852328 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patterns of dyslipidemia were higher in subjects diagnosed with insulin resistance. | 18852934 |
| Hypertriglyceridemia, Hypoalphalipoproteinemias | Deregulated Nutrient Sensing | Insulin resistance associated with hypertriglyceridemia and hypoalphalipoproteinemia was common among our studied population. | 18852934 |
| Hypoalphalipoproteinemias, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | In addition, 36.8% of the obese individuals (as measured by waist perimeter) had hypertriglyceridemia/hypoalphalipoproteinemia, 35.2% had mixed dyslipidemia, and 33.4% had hypertriglyceridemia. | 18852934 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes. | 18854016 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Recent studies reported that retinol-binding protein 4 (RBP4) has a causal role in insulin resistance and suggested that its circulating levels may predict cardiovascular disease. | 18854400 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | At baseline, all patients had normal insulin levels, C-peptide, and homeostatic model assessment of insulin resistance index, except for one female diagnosed with type 2 diabetes. | 18854428 |
| Weight Gain | Deregulated Nutrient Sensing | We conclude that, in leptin-deficient adults, the interruption of r-metHuLeptin decreases insulin resistance in the context of rapid weight gain. | 18854428 |
| Hyperleucinemia, Obesity | Deregulated Nutrient Sensing | Our results suggest that hyperleptinemia may contribute to mediate the increased insulin resistance of obesity. | 18854428 |
| Hypertensive (finding), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease, adiponectin and insulin resistance in dipper and nondipper essential hypertensive patients. | 18854760 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial, and the presence of insulin resistance is recognized as the pathophysiological hallmark of this condition. | 18854760 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Arterial hypertension is referred as an insulin-resistant state, and insulin resistance may substantially contribute to the cardiovascular risk in this disorder. | 18854760 |
| Steatohepatitis, Hypertensive (finding), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In the absence of major risk factors for the development of NAFLD, a high prevalence of liver steatosis was associated with insulin resistance and low adiponectin levels in essential hypertensive patients with a nondipping profile. | 18854760 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Urinary albumin excretion is a risk factor for diabetes mellitus in men, independently of initial metabolic profile and development of insulin resistance. | 18854761 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Most poorly documented was history of dyslipidaemia (53%) and obesity/ overweight (2%). | 18855517 |
| Prediabetes syndrome, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Dyslipidaemia is present not only in diabetic but also in prediabetic subjects. | 18922596 |
| Myositis, CTCAE 5.0 | Deregulated Nutrient Sensing | Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. | 18922603 |
| amyloid-beta binding | Deregulated Nutrient Sensing | Experimentally, increased activity of SIRT1 facilitates calorie-restricted longevity, and decreases NF-kappaB activation and the amount of the amyloid-beta (Abeta). | 18922603 |
| Myopathy, Myositis, CTCAE 5.0 | Deregulated Nutrient Sensing | We studied SIRT1 in an aging-associated muscle disease, sporadic inclusion-body myositis (s-IBM), whose muscle fibers contain increased NF-kappaB activation and abnormal accumulation of Abeta. | 18922603 |
| Disease | Deregulated Nutrient Sensing | To our knowledge, this is the first demonstration of SIRT1 abnormalities, including decreased SIRT1 deacetylase activity, in human disease associated with aging. | 18922603 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance and obesity are recognized as left ventricular (LV) mass determinants independent of blood pressure (BP). | 18929416 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Higher levels of education were associated with lower prevalences of diabetes and current smoking in both genders and lower prevalences of hypertension and dyslipidemia in women. | 18929705 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Several lines of evidence support the notion that elevated blood viscosity may predispose to insulin resistance and type 2 diabetes mellitus by limiting delivery of glucose, insulin, and oxygen to metabolically active tissues. | 18931370 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore, elevated blood viscosity and hematocrit deserve attention as emerging risk factors for insulin resistance and type 2 diabetes mellitus. | 18931370 |
| Hypertension, CTCAE, Depression, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | She enjoyed complete independence in all activities of daily living, although she had essential hypertension, dyslipidemia, mild depression and urinary frequency. | 18935752 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension is common among patients with dyslipidemia but is often poorly treated. | 18937013 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | In this clinical trial of dyslipidemia management, inadequately controlled hypertension was common, occurring in nearly 50% of individuals. | 18937013 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The dyslipidemia and insulin resistance of type 2 diabetes mellitus can be improved by aerobic exercise, but effects on LDL kinetics are unknown. | 18940401 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Prevalence of dyslipidemia in patients with type 2 diabetes in Jordan. | 18946566 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine the frequency and patterns of dyslipidemia in patients with type 2 diabetes mellitus (DM) and to estimate the effects of sociodemographic and clinical variables on dyslipidemia. | 18946566 |
| Dyslipidemias | Deregulated Nutrient Sensing | Over 90% of patients with type 2 DM had one or more types of dyslipidemia. | 18946566 |
| Triglycerides, Dyslipidemias | Deregulated Nutrient Sensing | The most common dyslipidemia in our study was high LDL-cholesterol and high triglycerides as reported in the literature. | 18946566 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We hypothesised that proinsulin and insulin resistance contributes to an increase of risk for fatal and non-fatal stroke/TIA, independently of diabetes and established risk factors. | 18949454 |
| Obesity, Abdominal, Dyslipidemias, Coronary heart disease, Cerebrovascular accident, Hypertension, CTCAE | Deregulated Nutrient Sensing | High risk (HR) was defined as having 3-5 factors: abdominal obesity, BMI >or= 28 kg/m2, dyslipidemia, hypertension, coronary heart disease, or stroke. | 18954500 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. | 18955782 |
| Hyperferritinaemia | Deregulated Nutrient Sensing | Hyperferritinemia is associated with insulin resistance and fatty liver in patients without iron overload. | 18958176 |
| Steatohepatitis, Hemochromatosis, Hyperferritinaemia | Deregulated Nutrient Sensing | The present results suggest that liver steatosis and insulin resistance but not increased iron load is frequently seen in patients referred for suspected hemochromatosis on the basis of hyperferritinemia. | 18958176 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Adiponectin is an adipocyte hormone that ameliorates insulin resistance and prevents diabetes. | 18971537 |
| Anxiety, CTCAE 3.0, Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | Anxiety symptoms were associated with depressive symptoms (OR 5.49, 95%CI 2.89-10.43) and negatively associated with dyslipidemia (OR 0.48, 95%CI 0.25-0.94). | 18972905 |
| Dyslipidemias | Deregulated Nutrient Sensing | Assessment of the efficacy and tolerability of a fixed dose combination of atorvastatin 10 mg + metformin SR 500 mg in diabetic dyslipidaemia in adult Indian patients. | 18975505 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | A new fixed dose combination containing atorvastatin 10 mg + metformin SR 500 mg is being introduced in the Indian market for the treatment of dyslipidaemia in diabetic patients. | 18975505 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, the results of the present study suggest that, the fixed dose combination of atorvastatin 10 mg + metformin SR 500 mg is efficacious and well tolerated therapeutic modality in patients with diabetic dyslipidaemia. | 18975505 |
| Dyslipidemias | Deregulated Nutrient Sensing | Furthermore this combination offers dosage convenience to the patient and by virtue of its dual mode of action is a useful addition to the therapeutic armamentarium for patients with diabetic dyslipidaemia. | 18975505 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insufficient renal 1-alpha hydroxylase and bone homeostasis in aged rats with insulin resistance or type 2 diabetes mellitus. | 18979155 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Hydrochlorothiazide, but not Candesartan, aggravates insulin resistance and causes visceral and hepatic fat accumulation: the mechanisms for the diabetes preventing effect of Candesartan (MEDICA) Study. | 18981327 |
| palladium, Left Ventricular Hypertrophy, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia often occurs in PD but it remains unclear whether dyslipidemia is related to LVH. | 18981390 |
| Dyslipidemias, Pathologic Intimal Thickening | Deregulated Nutrient Sensing | Study of the intima-media thickening in carotid arteries of healthy elderly with high blood pressure and elderly with high blood pressure and dyslipidemia. | 18982922 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The etiology and pathogenesis of type 2 diabetes mellitus (T2DM) are not completely understood although it is often associated with other conditions such as obesity, hypertension, and dyslipidemia. | 18985010 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This result supports the importance of impaired antioxidant status for the development of insulin resistance and type 2 diabetes. | 18985315 |
| Steatohepatitis, Sleep Apnea, Obstructive, Obesity | Deregulated Nutrient Sensing | Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity. | 18990675 |
| Sleep Apnea, Obstructive, Injury of liver | Deregulated Nutrient Sensing | Obstructive sleep apnea is associated with insulin resistance and liver injury. | 18990675 |
| Steatohepatitis, Apnea, Obesity | Deregulated Nutrient Sensing | It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity. | 18990675 |
| Respiratory disturbances | Deregulated Nutrient Sensing | There was no relationship between the respiratory disturbance index and insulin resistance or liver histopathology. | 18990675 |
| Steatohepatitis, Sleep Apnea, CTCAE, Obesity | Deregulated Nutrient Sensing | Hypoxic stress of sleep apnea may be implicated in the development of insulin resistance and steatohepatitis in severe obesity. | 18990675 |
| Obesity, Abdominal, Cardiovascular Diseases | Deregulated Nutrient Sensing | An increment in the androgenic milieu that correlates with abdominal fat, insulin resistance and atherogenic lipoproteins becomes evident after the menopausal transition and suggests that evaluation of cardiovascular disease risk in these women should include androgens, considering that abdominal obesity is one of the main determinants of the relationship between androgenic parameters and cardiovascular risk factors. | 18991078 |
| Dyslipidemias | Deregulated Nutrient Sensing | In patients with mixed dyslipidemia, combination therapy with ABT-335+rosuvastatin resulted in more effective control of multiple lipid parameters than either monotherapy alone, with a safety profile similar to both monotherapies. | 18996523 |
| Dyslipidemias | Deregulated Nutrient Sensing | This combination may be an appropriate therapeutic option to treat mixed dyslipidemia. | 18996523 |
| Congenital adrenal hyperplasia | Deregulated Nutrient Sensing | Metformin, an agent known to reduce insulin resistance, further suppressed the 17-hydroxyprogesterone concentration in a patient with classic congenital adrenal hyperplasia on steroid replacement therapy. | 18996819 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | The adiponectin level has been linked to insulin resistance, dyslipidemia and coronary artery disease. | 19000491 |
| Autoimmune Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Kidney Failure | Deregulated Nutrient Sensing | Our conclusions are that 1) the need for insulin treatment in LADA is linked to the degree of autoimmunity and beta-cell failure, 2) subjects with LADA and type 2 diabetes without the need for insulin treatment are phenotypically similar, and 3) insulin treatment in type 2 diabetic patients is associated with both insulin resistance and beta-cell insufficiency. | 19001190 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A novel adipokine, retinol binding protein-4 (RBP4), was reported to be associated with insulin resistance and the prevalence of type 2 diabetes. | 19003725 |
| Glucose Intolerance (disease), Sleep Apnea, Obstructive, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | This study indicates that plasma RBP4 is associated with dyslipidemia, but not with insulin resistance, glucose intolerance, or hypertension in patients with OSAS. | 19003725 |
| Glucose Intolerance (disease), Obesity, Visceral | Deregulated Nutrient Sensing | It is concluded that low SHBG concentrations may indicate visceral obesity and glucose intolerance in premenopausal women. | 19008614 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Hypertensive patients presented lower improvement in QOL scores when compared to non-hypertensive ones [8.3(0-25) vs. 16.6(0-33.3); P=0.05], as well as patients with dyslipidemia, when compared to non-dyslipidemic ones [8.3(0-25) vs. 16.6(0-33.3); P=0.02]. | 19009175 |
| Impaired T cell function | Deregulated Nutrient Sensing | The pathophysiology of IFG-IGT (having both B-cell dysfunction and insulin resistance) indicates that it may be a different entity and not be included in IGT. | 19010062 |
| CAV1 gene, Dyslipidemias | Deregulated Nutrient Sensing | At multivariate analysis, dyslipidemia was the most significant CVRF (P = .045) for the development of CAV. | 19010192 |
| CAV1 gene, Dyslipidemias, Haiti | Deregulated Nutrient Sensing | Recipient dyslipidemia is a risk factor for the development of CAV in HT. | 19010192 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | Statins, although the treatment of choice for dyslipidemia after heart transplantation (HT), are not always well tolerated or effective. | 19010194 |
| Nonalcoholic Steatohepatitis, Dyslipidemias | Deregulated Nutrient Sensing | Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. | 19013295 |
| Coronary Arteriosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance (IR) is a risk factor for diabetes and atherosclerotic diseases. | 19013381 |
| Dyslipidemias, Albuminuria, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Establishment of treatment goals for control of cardiovascular risk factors (blood pressure, dyslipidemia, diabetes mellitus,) and albuminuria to reduce the rate of progression of kidney disease. | 19018732 |
| Lipodystrophy | Deregulated Nutrient Sensing | No associations between insulin resistance and lipodystrophy or treatment regimen were detected. | 19018877 |
| Lipodystrophy | Deregulated Nutrient Sensing | Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy. | 19018877 |
| Menopause, Hypertension, CTCAE, physiopathological | Deregulated Nutrient Sensing | Menopause, hypertension and abnormal stress tests were significantly more prevalent, adiponectin level was significantly decreased, CRP, insulin resistance, and EFT were significantly increased in women with microvascular dysfunction as compared with those without. | 19019370 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Niacin is a preferred option for Lp(a) lowering in very-high-risk patients with coronary heart disease and dyslipidemia. | 19019811 |
| Atherosclerosis | Deregulated Nutrient Sensing | One hundred and eighty-seven normolipidaemic, non-diabetic lean or obese subjects with or without insulin resistance participating in the Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk (SAPHIR) were included in the study. | 19021700 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic low-grade inflammation has been associated with insulin resistance and type 2 diabetes. | 19022962 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore, these results show that CP can lower hsCRP, a marker of inflammation associated with insulin resistance and type 2 diabetes. | 19022962 |
| Multiple Organ Failure | Deregulated Nutrient Sensing | Insulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome. | 19025444 |
| Sepsis | Deregulated Nutrient Sensing | Insulin resistance (IR) is a major factor in the pathogenesis of sepsis. | 19025444 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The prevalence of the main risk factors detected was: 39.3% overweight and 6.8% obese, mainly among men (60.4%), 41.8% for central obesity mainly among women (66.7%), 68% for dyslipidaemia and 15.4% for blood pressure alterations mainly among men (24.7%). | 19028731 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | In total, 86% of the patients had hypertension, 43% had dyslipidaemia and 44% had a history of cardiovascular disease. | 19028750 |
| Inflammation, AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A, a protein almost exclusively secreted by the liver, induces insulin resistance and subclinical inflammation in rodents. | 19029462 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | After adjustment for age, sex, body mass index, diabetes mellitus, smoking, physical inactivity, dyslipidemia, previous cardiovascular diseases, serum creatinine level, and number of antihypertensive drugs in use, no office BP showed any prognostic value. | 19029499 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Approximately two thirds of the participants (68%) had dyslipidemia, 79.9% hypertension, and 24% prior myocardial infarction. | 19033001 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Food intake patterns associated with incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study. | 19033409 |
| Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study cohort included 880 middle-aged adults initially free of diabetes. | 19033409 |
| Heart failure | Deregulated Nutrient Sensing | The beta2 adrenergic receptor Gln27Glu polymorphism affects insulin resistance in patients with heart failure: possible modulation by choice of beta blocker. | 19034036 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance is prevalent in heart failure (HF) patients, and beta2 adrenergic receptors (beta2-AR) are involved in glucose homeostasis. | 19034036 |
| Glucose Intolerance (disease), Pre-Gestational Diabetes, Cardiovascular Diseases | Deregulated Nutrient Sensing | The offspring of mothers with pre-gestational type 1 diabetes (PGDM) may be at increased risk of glucose intolerance and cardiovascular disease in childhood. | 19034420 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | At cohort entry, the mean patient age was 65 years, 37.3% were male, 8.6% had diabetes, and 19.5% had dyslipidemia. | 19038916 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Male gender, occurrence of cardiovascular disease during follow-up, and dyslipidemia were risk factors for CD. | 19038916 |
| Muscle hypertrophy, Familial generalized lipodystrophy, Autosomal recessive inheritance | Deregulated Nutrient Sensing | Berardinelli-Seip congenital lipodystrophy (BSCL) is a rare autosomal recessive condition associating insulin resistance, absence of subcutaneous fat and muscular hypertrophy. | 19041432 |
| Liver diseases, Alcoholic Intoxication, Chronic, Glucose Intolerance (disease), Malignant Neoplasms, Hyperuricemia | Deregulated Nutrient Sensing | The disease is frequently associated with alcoholism, hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways, requiring thorough clinical evaluation of all patients. | 19042074 |
| Hypertension, CTCAE, ASAH1 wt Allele, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, dyslipidemia and impaired glucose metabolism were demonstrated in severe PHP, with improvement after surgery in these variables. | 19043371 |
| Dyslipidemias, Albuminuria, Diabetes Mellitus | Deregulated Nutrient Sensing | To explore the association between dyslipidaemia and albuminuria at the extreme of diabetes duration. | 19046204 |
| Communicable Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A link between chronic hepatitis C virus (HCV) infection, Type 2 diabetes mellitus and insulin resistance has been suggested by several studies. | 19046205 |
| Hepatitis C, Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | These data suggest an association between HCV virus infection and the development of insulin resistance or diabetes mellitus without the typical features of the metabolic syndrome. | 19046205 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | A common functional ENPP1 K121Q polymorphism has been suggested to contribute to insulin resistance, obesity and type 2 diabetes (T2D) in various ethnic groups. | 19046915 |
| Pulmonary arterial hypertension, Polycyclic Hydrocarbons, Aromatic, Cardiovascular Diseases, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Although obesity, dyslipidemia and insulin resistance (IR) are well known risk factors for systemic cardiovascular disease, their impact on pulmonary arterial hypertension (PAH) is unknown. | 19047320 |
| Pulmonary arterial hypertension | Deregulated Nutrient Sensing | Insulin resistance appears to be more common in pulmonary arterial hypertension females than in the general population, and may be a novel risk factor or disease modifier that might impact on survival. | 19047320 |
| Weight decreased | Deregulated Nutrient Sensing | Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss. | 19050176 |
| Obesity, Visceral | Deregulated Nutrient Sensing | Controversy exists as to whether endogenous cortisol production is associated with visceral obesity and insulin resistance in humans. | 19050176 |
| Weight decreased | Deregulated Nutrient Sensing | These data support a model in which increased hypothalamic-pituitary-adrenal activity in men promotes selective visceral fat accumulation and insulin resistance and may promote weight regain after diet-induced weight loss, whereas 11beta-HSD-1 gene expression in SQF is a consequence rather than cause of adiposity. | 19050176 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Among individual MetS components, incident MI was independently associated with three of them: low high-density lipoprotein-cholesterol (OR = 2.03, CI = 1.09-3.78, P = 0.025) insulin resistance (OR = 2.02, CI = 1.08-3.78, P = 0.028) and increased albumin excretion rate (OR = 1.24, CI = 0.99-1.55, P = 0.060). | 19050451 |
| Pancreatic carcinoma, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance have been implicated in the etiology of pancreatic cancer (PC). | 19051043 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Preventing cardiovascular disease among Canadians: is the treatment of hypertension or dyslipidemia cost-effective? | 19052668 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Plasma pre beta1-HDL levels have been reported to be increased in patients with coronary artery disease (CAD) and dyslipidemia. | 19054517 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Coadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia. | 19057518 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship of serum gamma-glutamyltransferase to atherogenic dyslipidemia and glycemic control in type 2 diabetes. | 19057528 |
| Hypercholesterolemia, Dyslipidemias, Hypertension, CTCAE, Hyperuricemia | Deregulated Nutrient Sensing | As GGT concentration increased, the association of BMI with atherogenic dyslipidemia and glycemic control strengthened (P = 0.01 and 0.004 for interactions, respectively); in contrast, the association of BMI with hypertension, hypercholesterolemia, and hyperuricemia did not change substantially across GGT quartiles. | 19057528 |
| Dyslipidemias | Deregulated Nutrient Sensing | For example, within the lowest GGT quartile, BMI was not associated with atherogenic dyslipidemia or poor glycemic control, whereas in the highest GGT quartile, the prevalence rates ranged from 62.3 to 74.7% for dyslipidemia and from 75.3 to 83% for poor glycemic control. | 19057528 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, our findings show that BMI was associated with atherogenic dyslipidemia and poor glycemic control only when serum GGT activity was in its high-normal range. | 19057528 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | These findings suggest that obesity itself may not be a sufficient risk factor for atherogenic dyslipidemia or poor glycemic control in people with type 2 diabetes. | 19057528 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Familial hypertriglyceridemia (FHTG) is an uncommon primary (genetic) dyslipidemia. | 19057857 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In non-obese NAFLD patients: 1) although visceral fat was increased, insulin resistance and/or dysregulated secretion of adipocytokines was not necessarily shown; 2) intakes of total energy and carbohydrates were not excessive, although dietary cholesterol was superabundant and dietary PUFAs were significantly lower compared with those in obese patients; and 3) characteristic fat intake may be associated with the formation of NAFLD. | 19058085 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no significant difference in the percentage of patients with diabetes or dyslipidemia between the obese and non-obese groups. | 19058085 |
| Dyslipidemias, Cholestasis, Intrahepatic Cholestasis | Deregulated Nutrient Sensing | No appropriate pharmaceutical therapy has been established for dyslipidemia with cholestasis in progressive familial intrahepatic cholestasis (PFIC)-1. | 19059530 |
| Dyslipidemias, Cholestasis, Pruritus | Deregulated Nutrient Sensing | Bezafibrate treatment favorably affected pruritus, dyslipidemia, and cholestasis in PFIC-1. | 19059530 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Screening for and management of dyslipidaemia are crucial in primary and secondary prevention of cardiovascular disease. | 19059566 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Because E2 levels tend to be elevated in morbid obesity, insulin resistance, and diabetes, it is reasonable to hypothesize that high E2 levels are associated with MS in older men. | 19059904 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Consistently with this, RNA interference-mediated knockdown of Sirt1, but not Sirt2, induced apoptosis in cancer cells. | 19060927 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | We were finally able to ascribe the apoptotic effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. | 19060927 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, dyslipidemia, and obesity were associated with lower scores in the physical domain. | 19061001 |
| Sleep Disorders, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Sleeping disorders in type 2 diabetic patients constitute risk factors for aggravating diabetes since they can affect the metabolic control through insulin resistance syndrome. | 19061021 |
| Erectile dysfunction | Deregulated Nutrient Sensing | To determine whether patients with erectile dysfunction (ED) have a higher incidence of insulin resistance (IR) when compared with controls. | 19062003 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. | 19064532 |
| Hypertension, CTCAE, Endothelial dysfunction | Deregulated Nutrient Sensing | Essential hypertension is characterized by reciprocal relations between endothelial dysfunction and insulin resistance. | 19064532 |
| Hypertension, CTCAE, Endothelial dysfunction | Deregulated Nutrient Sensing | The objective was to test the hypothesis that consumption of cocoa may simultaneously lower blood pressure, improve endothelial dysfunction, and ameliorate insulin resistance in subjects with essential hypertension. | 19064532 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Daily consumption of flavanol-rich cocoa for 2 wk is not sufficient to reduce blood pressure or improve insulin resistance in human subjects with essential hypertension. | 19064532 |
| Esophageal Varices, Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis. | 19065558 |
| Fibrosis Assessment, Hypertension, CTCAE, Liver Stiffness | Deregulated Nutrient Sensing | We tested the effectiveness of liver stiffness measurement (LSM) by transient elastography and the presence of insulin resistance (IR), a marker associated with fibrosis progression, in the noninvasive prediction of portal hypertension. | 19065558 |
| Diabetes Mellitus, Obesity, Congenital Abnormality | Deregulated Nutrient Sensing | Obesity and 2-type diabetes are well-known fetal malformation etiologies, due to insulin resistance. | 19065822 |
| Somatotropin deficiency | Deregulated Nutrient Sensing | GH treatment in GH-deficient (GHD) patients may cause insulin resistance and exerts ambiguous effects on inflammatory markers. | 19067726 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Being overweight/obese is associated with hypertension and dyslipidemia. | 19072098 |
| Hypothyroidism | Deregulated Nutrient Sensing | Insulin resistance is closely related to post-THW hypothyroidism in patients of DTC. | 19072673 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients whose GFR was <60 mL/min/1.73 m2 were older, prevalently female, had increased pulse pressure and higher prevalence of dyslipidaemia. | 19073656 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Role of sirtuin histone deacetylase SIRT1 in prostate cancer. | 19075016 |
| Structure of posterior cerebral artery | Deregulated Nutrient Sensing | Our data suggested that SIRT1, via inhibiting FOXO1 activation, could contribute to the development of PCa. | 19075016 |
| Structure of posterior cerebral artery | Deregulated Nutrient Sensing | We suggest that SIRT1 could serve as a target toward developing novel strategies for PCa management. | 19075016 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Therefore, 86.1% (279) of cases with WCH were either overweight or obese, and 41.3% (134) of all WCH cases had dyslipidemia. | 19075483 |
| Family history | Deregulated Nutrient Sensing | These results indicate that insulin resistance and endothelial activation were found in normotensive adolescents with an FH. | 19078988 |
| Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease), square decimeter, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine whether in the Mexican population the spouses of patients with type 2 diabetes mellitus (DM2) have an increased risk of any degree of glucose intolerance compared with spouses of subjects without diabetes. | 19080850 |
| Obesity | Deregulated Nutrient Sensing | Inflammatory stimuli are causative for insulin resistance in obesity as well as in acute inflammatory reactions. | 19087258 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women. | 19088327 |
| flavin-hypoxanthine dinucleotide, Obesity | Deregulated Nutrient Sensing | The objective of this study was to measure the independent association of serum adiponectin with FHD in relation to insulin resistance and obesity. | 19088327 |
| flavin-hypoxanthine dinucleotide | Deregulated Nutrient Sensing | The relationship between adiponectin and FHD was similar between the high and low insulin resistance, BMI, and WC groups in male non-smokers and in all Korean women. | 19088327 |
| flavin-hypoxanthine dinucleotide, Obesity | Deregulated Nutrient Sensing | These data also suggest that the association of serum adiponectin with FHD may be independent of obesity and insulin resistance. | 19088327 |
| Peripheral Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia, smoking, sedentary lifestyle, and peripheral arterial disease were more frequent in men. | 19090879 |
| Hyperinsulinism, Hepatitis C, Paresis | Deregulated Nutrient Sensing | As part of his hepatitis C infection, marked insulin resistance with hyperinsulinaemia was also present, exacerbating the paresis. | 19092328 |
| Alopecia, CTCAE | Deregulated Nutrient Sensing | Androgenetic alopecia and insulin resistance in young men. | 19094069 |
| Hypertension, CTCAE, Coronary Artery Disease, Androgenetic Alopecia | Deregulated Nutrient Sensing | Epidemiological studies have associated androgenetic alopecia (AGA) with severe young-age coronary artery disease and hypertension, and linked it to insulin resistance. | 19094069 |
| pyruvate synthase activity, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients without PFO were more likely to be current smokers and obese and more frequently had a history of hypertension and dyslipidemia. | 19095992 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes. | 19097921 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalences of dyslipidemia and diabetes mellitus were 48% and 24%, respectively. | 19098372 |
| Coronary Artery Disease, Coronary Lesions Treated | Deregulated Nutrient Sensing | [Association among circulating endothelial progenitor cells, insulin resistance and severity of coronary lesions in patients with coronary artery disease]. | 19100113 |
| Coronary artery | Deregulated Nutrient Sensing | Insulin resistance/hyperinsulinemia could aggravate severity of coronary artery lesions via reducing the number and activities of circulating EPCs in patients with CAD. | 19100113 |
| Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cerebrovascular accident | Deregulated Nutrient Sensing | Age, duration of atrial fibrillation, history of dyslipidemia and history of diabetes were the main risk factors related to stroke and the clustering of risk factors would further increase the risk. | 19103122 |
| Hypertensive (finding), Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | However, few studies have assessed the benefits of cholesterol lowering for primary prevention of coronary heart disease in hypertensive patients with mild dyslipidemia or without conventional dyslipidemia. | 19104004 |
| Data types - Address | Deregulated Nutrient Sensing | Because sirtuins may increase the life span through regulation of cellular metabolism, we compared the concentration of sirtuin 1 (SIRT1) in the brains of AD patients (n = 19) and controls (n = 22) using Western immunoblots and in situ hybridization. | 19104446 |
| Data types - Address | Deregulated Nutrient Sensing | We report a significant reduction of SIRT1 (messenger RNA [mRNA], -29%; protein, -45%) in the parietal cortex of AD patients, but not in the cerebellum. | 19104446 |
| Impaired cognition, Data types - Address | Deregulated Nutrient Sensing | Further analyses in a second cohort of 36 subjects confirmed that cortical SIRT1 was decreased in AD but not in individuals with mild cognitive impairment. | 19104446 |
| Cessation of life | Deregulated Nutrient Sensing | A significant relationship between SIRT1 levels and global cognition scores proximate to death was also found (r2= +0.09, p = 0.049). | 19104446 |
| Data types - Address | Deregulated Nutrient Sensing | In contrast, cortical SIRT1 levels remained unchanged in a triple-transgenic animal model of AD. | 19104446 |
| amyloid-beta binding, Data types - Address | Deregulated Nutrient Sensing | Collectively, our results indicate that loss of SIRT1 is closely associated with the accumulation of amyloid-beta and tau in the cerebral cortex of persons with AD. | 19104446 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. | 19104446 |
| Obesity | Deregulated Nutrient Sensing | Our results suggest that menopause-related insulin resistance, obesity and ethanol ingestion as well as menopause may contribute to an increase in level of serum urate in postmenopausal Japanese women. | 19105055 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes. | 19106274 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes risk. | 19106274 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance. | 19106274 |
| Obesity, Dyslipidemias, Metabolic Syndrome X, Bipolar Disorder | Deregulated Nutrient Sensing | Our results suggest that the metabolic syndrome, in particular the obesity and dyslipidemia components, is predictive of depressive symptoms. | 19106378 |
| Obesity | Deregulated Nutrient Sensing | Decline in physical fitness from childhood to adulthood associated with increased obesity and insulin resistance in adults. | 19106381 |
| Obesity | Deregulated Nutrient Sensing | To examine how fitness in both childhood and adulthood is associated with adult obesity and insulin resistance. | 19106381 |
| Obesity | Deregulated Nutrient Sensing | Lower levels of child cardiorespiratory fitness were associated with increased odds of adult obesity (adjusted odds ratio [OR] per unit decrease 3.0 [95% CI 1.6-5.6]) and insulin resistance (1.7 [1.1-2.6]). | 19106381 |
| Obesity | Deregulated Nutrient Sensing | A decline in fitness level between childhood and adulthood was associated with increased obesity (4.5 [2.6-7.7]) and insulin resistance (2.1 [1.5-2.9]) per unit decline. | 19106381 |
| Obesity | Deregulated Nutrient Sensing | A decline in fitness from childhood to adulthood, and by inference a decline in physical activity, is associated with obesity and insulin resistance in adulthood. | 19106381 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | It has been hypothesized that abdominal obesity leads to insulin resistance partly through decreased adiponectin. | 19107128 |
| Communicable Diseases, Hepatitis C, Obesity | Deregulated Nutrient Sensing | The clinical course of chronic hepatitis C virus (HCV) infection is strongly associated with insulin resistance and obesity. | 19107338 |
| Obesity | Deregulated Nutrient Sensing | The K121Q polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 gene and the rs7566605 genotype located near insulin-induced gene 2 have been shown to be associated with insulin resistance and obesity. | 19107338 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study was designed to compare the insulin sensitizing effects of thiazolidinediones (TZDs) on the degree of insulin resistance, determined by a short insulin tolerance test (Kitt) in type 2 diabetic patients. | 19108012 |
| ACSM3 gene | Deregulated Nutrient Sensing | Homozygosity for SAH haplotype 3 was associated with increased adiposity, insulin resistance, and elevated levels of non-HDL-C in the post menopausal women. | 19108963 |
| One Vessel Coronary Disease, Dyslipidemias | Deregulated Nutrient Sensing | More men had multivessel disease (78.8 vs. 62.5%, p<0,001), dyslipidaemia (73.2 versus 65.4%, p<0.05), smoking habit (74.3 versus 34.5%, p<0.001) or prior revascularisation (49.7 versus 36.1%, p<0.05). | 19110808 |
| Osage language | Deregulated Nutrient Sensing | OSA is associated with increased insulin resistance, but studies of continuous positive airway pressure (CPAP) have shown inconsistent effects on glycemic control. | 19110882 |
| Beta-Cell Function Measurement, IFNG wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Failure of beta-cell function might be the main reason for both IGT and IFG developing into diabetes instead of aggravated insulin resistance. | 19116942 |
| Pentalogy of Cantrell, Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin attenuated the relationship between VAT and TAS, suggesting that adiponectin and insulin resistance is an important link between visceral adiposity and atherosclerosis. | 19118830 |
| Hypertensive (finding), glucose metabolism | Deregulated Nutrient Sensing | In hypertensive patients with IGT telmisartan compared to losartan improved endothelial function and insulin resistance independently, supporting the hypothesis that glucometabolic and vascular insulin resistance are differentially regulated. | 19118910 |
| Dyslipidemias | Deregulated Nutrient Sensing | The women had a high rate of dyslipidemia (33%) and engaged in an average of 9187 steps/day (SD 3671). | 19121220 |
| Metabolic Diseases, square decimeter, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance and lipid metabolism disorder are the chief risk factors in DM2 patients complicated with FL and phlegm-dampness is the chief pathogenesis. | 19123321 |
| Increased insulin level, Colorectal Carcinoma, Obesity | Deregulated Nutrient Sensing | Obesity, particularly visceral adiposity, is an established risk factor for colorectal cancer (CRC) and this is thought to result, at least in part, from insulin resistance and chronic hyperinsulinemia that may be mediated by adipokines. | 19123482 |
| Increased insulin level, Obesity | Deregulated Nutrient Sensing | Serum levels of adiponectin, the most abundant protein secreted from adipocytes, are decreased in obesity and are inversely associated with insulin resistance and hyperinsulinemia. | 19123482 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adipokines are associated with increased adiposity, insulin resistance, and atherosclerosis. | 19126626 |
| Hypothyroidism | Deregulated Nutrient Sensing | These results may have significant clinical implications because of the high prevalence of both hypothyroidism and insulin resistance in the aging population. | 19127201 |
| Sleep Apnea, CTCAE | Deregulated Nutrient Sensing | Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. | 19127383 |
| Acromegaly | Deregulated Nutrient Sensing | After adjusting for body mass index (BMI), acromegalic patients presented a more atherogenic lipoprotein profile, consisting of higher levels of triglycerides and apolipoprotein B and alterations in the ratios which estimate insulin resistance and atherogenic risk. | 19128365 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Despite the marked decrease in progression to diabetes and the improvement in insulin resistance and other cardiovascular risk markers in the ILS and metformin groups, there was no improvement in ACR, on average, in those two groups. | 19131464 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Moreover, Cav-1 is involved in SMC differentiation and dyslipidemia confirming the importance of lipid homeostasis in the atherosclerotic phenotype. | 19134193 |
| Inflammation, Coronary Artery Disease | Deregulated Nutrient Sensing | Synergistic role of inflammation and insulin resistance as coronary artery disease risk factors in African Americans and Caucasians. | 19135196 |
| Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | The separate roles of inflammation and insulin resistance (IR) in the pathogenesis of cardiovascular disease (CVD) are well recognized. | 19135196 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Based on questionnaire application, the following data were collected: family structure, socioeconomic level, obesity presence and dyslipidemia in close family relatives, breast feeding, birth weight, child's gestation conditions, feeding habits and the lifestyles of both children and parents. | 19137988 |
| Dyslipidemias | Deregulated Nutrient Sensing | This reduction was obtained without any apparent unfavourable side effects such as increased insulin secretion, impaired glucose tolerance or dyslipidaemia. | 19140039 |
| Left Ventricular Hypertrophy, Dyslipidemias, Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | The risk of abnormal LVMI values in echocardiogram increased in age over 65 (OR 3.64), in the presence of atherogenic dyslipidaemia (OR 1.73), diabetes (OR 1.68), clinical signs of atherosclerosis (OR 4.36), eGFR < 60 ml/min/1.73 m2 (OR 1.90) and ECG LVH (OR 1.53). | 19145927 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance and carotid atherosclerosis in patients with type 2 diabetes. | 19147142 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance may provide a crucial link between type 2 diabetes and cardiovascular disease. | 19147142 |
| Increased insulin level, Atherosclerosis | Deregulated Nutrient Sensing | However, it is still unclear whether insulin resistance itself or hyperinsulinemia is independently associated with subclinical atherosclerosis. | 19147142 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Carotid Atherosclerosis | Deregulated Nutrient Sensing | We hypothesized that insulin resistance, but not hyperinsulinemia, would be associated with carotid atherosclerosis in patients with type 2 diabetes. | 19147142 |
| Carotid Atherosclerosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Furthermore, odds ratio for carotid atherosclerosis was 1.43 (95% CI: 1.10, 1.86) in type 2 diabetic patients with insulin resistance (lowest quartile of insulin sensitivity) adjusting for known risk factors. | 19147142 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Carotid Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance measured by short insulin tolerance test, but not hyperinsulinemia, is independently associated with carotid atherosclerosis in patients with type 2 diabetes. | 19147142 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | However, damage was correlated with a marked narrowing of the supplying arterioles as a consequence of hemodynamic and/or metabolic alterations (dyslipidemia, diabetes). | 19148350 |
| Discordance, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The discordance between the percentages of elevated LDL-c and Total cholesterol (T-c) signifies the role of the LDL-c/non-HDL-c as the main surrogate for dyslipidaemia as a risk for atherosclerosis, and as a primary target of therapy. | 19149212 |
| Acute Coronary Syndrome, Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | Dyslipidemia is common in patients with acute coronary syndromes (ACS) but the mechanism remains unclear. | 19150068 |
| Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Both dyslipidemia and hypertension are important risk factors for cardiovascular disease. | 19150527 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Studies have found that there is a higher risk of dyslipidemia among hypertensive patients. | 19150527 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | This study was designed to investigate the epidemiologic features of some forms of dyslipidemia in rural hypertensive adults in China. | 19150527 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of normotriglyceridemic hypoalphalipoproteinemia and severe dyslipidemia was 2.0% and 3.3%, respectively. | 19150527 |
| Hypertriglyceridemia, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The prevalence of isolated hypertriglyceridemia, mixed dyslipidemias, and severe dyslipidemia was higher in diabetic patients compared with nondiabetic patients, in either men or women. | 19150527 |
| Hypertriglyceridemia, Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | Compared with those of normal weight, obese men had a higher prevalence of mixed dyslipidemias and hypertriglyceridemia/hypoalphalipoproteinemia, whereas isolated hypertriglyceridemia was prevalent in both genders. | 19150527 |
| Demographics Domain, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Baseline higher heart rate (heart rate >or=80 bpm in 1979) predicted the development of obesity, diabetes mellitus (DM), and insulin resistance in 1999 after adjustments for age, sex, and other confounders. | 19151693 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Besides of DM, insulin resistance and high insulin levels are linked as well with increased cancer risk, including PC. | 19152242 |
| Hepatitis C, Hepatitis Virus-Related Hepatocellular Carcinoma | Deregulated Nutrient Sensing | Clinical expression of insulin resistance in hepatitis C and B virus-related chronic hepatitis: differences and similarities. | 19152451 |
| Carcinogenic Chlorinated Hydrocarbon, Complete atrioventricular block, Hepatitis C, Chronic, Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate the prevalence of the clinical parameters of insulin resistance and diabetes in patients affected by chronic hepatitis C (CHC) or chronic hepatitis B (CHB). | 19152451 |
| Hepatitis C | Deregulated Nutrient Sensing | These data may indicate that hepatitis C virus infection is a risk factor for insulin resistance. | 19152451 |
| Weight Gain, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The results of this study support the conclusion of the Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes that certain SGAs are associated with a higher risk for weight gain, insulin resistance and dyslipidemia. | 19153944 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The observed changes may predispose to insulin resistance and significantly increase the risk of developing cardiovascular disease in later life. | 19154768 |
| Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disorders | Deregulated Nutrient Sensing | We tested the hypothesis that elevated HGF is associated with insulin resistance and cardiovascular autonomic dysfunction in patients with type 2 diabetes mellitus not receiving insulin treatment. | 19154948 |
| Depressed mood, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results demonstrate that high levels of HGF are associated with depressed cardiovascular autonomic function and insulin resistance in patients with type 2 diabetes mellitus. | 19154948 |
| Hyperlipidemia, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Combined hyperlipidemia in relation to race/ethnicity, obesity, and insulin resistance in the Multi-Ethnic Study of Atherosclerosis. | 19154954 |
| Hyperlipidemia, Obesity | Deregulated Nutrient Sensing | We have asked whether the prevalence of combined hyperlipidemia (CHL) differs by race/ethnicity, obesity, and insulin resistance in a contemporary, multiethnic, US cohort. | 19154954 |
| Cardiovascular Diseases, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We determined the prevalence and adjusted odds of CHL in a cohort of 5923 men and women free of clinically recognized cardiovascular disease and diabetes according to race/ethnicity (white, Chinese, African American, and Hispanic), obesity, and insulin resistance. | 19154954 |
| Communicable Diseases, Hepatitis C, Diabetes Mellitus | Deregulated Nutrient Sensing | Serum retinol-binding protein 4 is inversely correlated with disease severity of chronic hepatitis C. Hepatitis C virus (HCV) infection carries a significant risk for development of insulin resistance (IR) and/or diabetes mellitus. | 19155083 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Women, especially having hypertension and dyslipidemia may be potential candidates for further risk stratification by MSCT coronary angiography. | 19155656 |
| Increased insulin level, Kidney Diseases | Deregulated Nutrient Sensing | Insulin-resistance hyperinsulinemia is a novel risk factor for renal disease in the general population. | 19155984 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Recently, soluble CD36 (sCD36) levels were reported to be elevated in type 2 diabetes, and to be tightly correlated with insulin resistance. | 19156623 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Increased HDL levels and the presence of insulin resistance syndrome in high risk asymptomatic subjects are predictive for arterial stiffness. | 19157269 |
| Glucose Intolerance (disease), Impaired cognition, Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance and diabetes as risk factors for cognitive impairment in people at high cardiovascular risk: results from the ONTARGET/TRANSCEND research programme. | 19157618 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results support the hypothesis that the longer alleles of the CAG and GGN polymorphisms in the exon-1 of the AR gene, indicative of lower androgenic signaling, respectively protect women from developing dyslipemia and men from developing insulin resistance. | 19159685 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease. | 19159917 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | Adiponectin is positively associated with insulin resistance in subjects with type 2 diabetic nephropathy and effects of angiotensin II type 1 receptor blocker losartan. | 19164322 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | Our results demonstrate that serum adiponectin levels in type 2 diabetic nephropathy are strongly positively associated with fasting insulin levels and insulin resistance. | 19164322 |
| Ischemic stroke | Deregulated Nutrient Sensing | Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients. | 19164796 |
| Dyslipidemias, Coronary Artery Disease, Chronic disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity as well as its associated chronic diseases and adverse health consequences such as type 2 diabetes mellitus, dyslipidemia, hypertension, and coronary artery disease are afflicting middle-aged adults and an ever greater number of children globally. | 19165168 |
| Dyslipidemias, Lupus Erythematosus, Lupus Erythematosus, Systemic, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia and lipoprotein pattern in systemic lupus erythematosus (SLE) and SLE-related cardiovascular disease. | 19165647 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. | 19166443 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. | 19167483 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We studied the association of SIRT1 genetic variation with mortality in subjects with increased oxidative stress (type 2 diabetes and smokers) in relation to dietary niacin. | 19167483 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In subjects with prevalent type 2 diabetes, homozygous carriers of the most common SIRT1 haplotype, 1, had 1.5 times (95%CI 1.1-2.1) increased mortality risk compared to noncarriers. | 19167483 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We conclude that in subjects with type 2 diabetes, SIRT1 genetic variation influences survival in interaction with dietary niacin and smoking. | 19167483 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes. | 19167483 |
| Diabetes Mellitus, Non-Insulin-Dependent, Periodontal Diseases | Deregulated Nutrient Sensing | Thus, the results suggested that periodontal treatment with topical antibiotics improves HbA1c through reduction of CRP, which may relate to amelioration of insulin resistance, in type 2 diabetic patients with periodontal disease. | 19168253 |
| Lipodystrophy | Deregulated Nutrient Sensing | As the patient presented with pubertal-onset of generalized lipodystrophy and insulin resistance, molecular analysis of the LMNA gene was performed. | 19169477 |
| Hyperinsulinemic hypoglycemia | Deregulated Nutrient Sensing | More pedigrees and long-term follow-up data are needed to document the evolution of beta-cell function and clarify the role of R1174 on insulin resistance and hyperinsulinaemic hypoglycaemia. | 19170714 |
| Structure of quadriceps femoris muscle | Deregulated Nutrient Sensing | Insulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged >or=70 years. | 19171728 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was defined according to the two criteria: high triglyceride and/or low high density lipoprotein cholesterol (TG > or = 150 mg and/or HDL-C < 40 mg/dl), and high total cholesterol (TC > or = 220 mg/dl). | 19176866 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Maintaining good oral hygiene by regular teeth brushing may prevent type 2 diabetes, hypertension and dyslipidemia. | 19176866 |
| Obesity | Deregulated Nutrient Sensing | Visfatin is a new cytokine that act as an insulin analogue on the insulin receptor and may link obesity and insulin resistance. | 19178507 |
| Thyroid dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia is a well-known manifestation of thyroid dysfunction. | 19178521 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence, awareness, and management of hypertension, dyslipidemia, and diabetes among United States adults aged 65 and older. | 19181717 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Adults aged 65 and older are disproportionately affected by hypertension, dyslipidemia, and diabetes, which are established risk factors for cardiovascular disease (CVD). | 19181717 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Goal attainment among those treated is problematic for all three conditions-hypertension (48.8%), dyslipidemia (64.9%), and diabetes (50.4%). | 19181717 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These measures may decrease insulin resistance, improve glycemic control, lipid abnormalities, and hypertension. | 19183462 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Insulin resistance is a candidate predictive factor for virological response to peginterferon plus ribavirin (PEG/RBV) therapy in chronic hepatitis C patients. | 19184426 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Insulin resistance seems to be a link between esRAGE and visfatin in IHD diabetics. | 19184512 |
| Dyslipidemias, Aortic Stiffness, Diabetes Mellitus | Deregulated Nutrient Sensing | Other variables associated with increased aortic stiffness were older age, heart rate, diabetes duration, 24h pulse pressure, dyslipidemia and physical inactivity. | 19185301 |
| Weight Gain, Hypertension, CTCAE, Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | There is suggestive evidence that chronic elevations of parathyroid hormone (PTH), associated with poor vitamin D status or low calcium intake, can increase risk for insulin resistance, weight gain, hypertension, and left ventricular hypertrophy, while stimulating production of acute phase reactants. | 19188028 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive disease | Deregulated Nutrient Sensing | In multivariate analysis, HBP prevalence was associated with older age, male sex, low educational level, high alcohol intake, awareness of diabetes or dyslipidaemia, obesity and parental history of myocardial infarction. | 19188810 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive disease | Deregulated Nutrient Sensing | HBP awareness was associated with older age, female sex, awareness of diabetes or dyslipidaemia, obesity and parental history of myocardial infarction. | 19188810 |
| ACACA wt Allele | Deregulated Nutrient Sensing | At 3-h AMPK activity and AMPK, ACC and AS160 phosphorylation were unchanged, but ERK1/2 phosphorylation increased at both AICAR doses. | 19190259 |
| Cell Death | Deregulated Nutrient Sensing | We hypothesised that increased insulin demand as a result of obesity/insulin resistance causes ER stress in pancreatic beta cells, thereby promoting beta cell death. | 19190890 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | In patients with mixed dyslipidemia characterized by increased triglycerides (TG), decreased high-density lipoprotein (HDL) cholesterol, and increased low-density lipoprotein (LDL) cholesterol, monotherapy with lipid-altering drugs often fails to achieve all lipid targets. | 19195513 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum retinal-binding protein 4 is positively related to insulin resistance in Chinese subjects with type 2 diabetes. | 19195734 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Prediction of type 2 diabetes using alternate anthropometric measures in a multi-ethnic cohort: the insulin resistance atherosclerosis study. | 19196891 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In contrast, measures of insulin resistance and adiponectin were not associated with weight change in this cohort of older persons without diabetes. | 19197256 |
| Glucose Intolerance (disease), Hepatitis B | Deregulated Nutrient Sensing | Prevalence of glucose intolerance in patients with chronic hepatitis B or C: a prospective case-control study. | 19200136 |
| Communicable Diseases, Glucose Intolerance (disease), Complete atrioventricular block, Carcinogenic Chlorinated Hydrocarbon, Hepatitis B, Chronic | Deregulated Nutrient Sensing | Despite several studies, the association of glucose intolerance with chronic hepatitis B (CHB) or C (CHC) virus infection remains controversial. | 19200136 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | OGTT was performed in all cases, except in known diabetics, and glucose intolerance was defined as impaired glucose tolerance (IGT), OGTT-diabetes or known diabetes. | 19200136 |
| Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular block, Diabetes Mellitus | Deregulated Nutrient Sensing | Compared with their own controls, CHB patients had a higher prevalence of IGT (13.6% vs 2.5%, P = 0.018) and family history of diabetes (34.6% vs 16.0%, P = 0.011), while CHC patents had higher prevalence of glucose intolerance (37.0% vs 15.7%, Rho = 0.001), mostly because of more frequent IGT (21.3% vs 6.5%, Rho = 0.003). | 19200136 |
| Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular block | Deregulated Nutrient Sensing | After age and BMI adjustment, patients with CHC compared with those with CHB had significantly higher prevalence of glucose intolerance (37.0% vs 29.6%, P = 0.037). | 19200136 |
| Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular block | Deregulated Nutrient Sensing | In conclusion, increased prevalence of glucose intolerance is documented by OGTT both in CHC and CHB patients compared with age, sex and BMI matched controls. | 19200136 |
| Carcinogenic Chlorinated Hydrocarbon, Glucose Intolerance (disease), Complete atrioventricular block | Deregulated Nutrient Sensing | Glucose intolerance is more frequent in CHC than CHB patients, regardless of known risk factors. | 19200136 |
| Gastrointestinal symptom, Liver Cirrhosis | Deregulated Nutrient Sensing | Liver cirrhosis is associated with increased prevalence of gastrointestinal symptoms, insulin resistance, and altered gut transit. | 19200458 |
| Dyslipidemias, S-Adenosylhomocysteine | Deregulated Nutrient Sensing | An association between obstructive sleep apnoea/hypopnea (OSAH) and cardiovascular risk factors such as dyslipidemia has been described in adults and high-risk populations. | 19200781 |
| Inflammation, Dyslipidemias, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Echogenecity of the carotid intima-media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. | 19200993 |
| glucose metabolism | Deregulated Nutrient Sensing | All patients were divided into groups according to glucometabolic and coronary status and insulin resistance. | 19202950 |
| Coronary heart disease | Deregulated Nutrient Sensing | There was no correlation between glycemic status and insulin resistance, and severity of coronary heart disease. | 19202950 |
| Inflammation, Hepatitis C, Atherosclerosis | Deregulated Nutrient Sensing | Hepatitis C virus infection in hemodialysis patients is not associated with insulin resistance, inflammation and atherosclerosis. | 19203507 |
| Hepatitis C, Endothelial dysfunction, Atherosclerosis | Deregulated Nutrient Sensing | In attempt to address this issue in chronic hemodialysis (HD) patients, we evaluated the relation of HCV infection with inflammatory markers, endothelial dysfunction, insulin resistance and atherosclerosis. | 19203507 |
| Communicable Diseases, Atherosclerosis | Deregulated Nutrient Sensing | HCV infection was not related to atherosclerosis and insulin resistance in hemodialysis patients. | 19203507 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Compared to normotensive subjects, those with high blood pressure showed a significantly higher prevalence of obesity, overweight, and dyslipidemia. | 19205546 |
| Coronary heart disease | Deregulated Nutrient Sensing | The findings suggest that insulin and insulin resistance exacerbate the adverse effect of PM(10) on cardiac autonomic control and thus risk of coronary heart disease among nondiabetic, postmenopausal women with impaired fasting glucose. | 19208727 |
| Dyslipidemias, Cardiovascular Diseases, Cardiovascular system | Deregulated Nutrient Sensing | Although statins are widely used for the prevention and management of cardiovascular disease in patients with dyslipidemia, the prevalence of cardiovascular comorbidities among statin users has not been well studied. | 19210153 |
| Heart Diseases, Atrial Fibrillation by ECG Finding, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | They were also more likely to have a past medical history of atrial fibrillation or hypertension, and less likely to have a history of heart disease, dyslipidemia, or smoking. | 19211482 |
| Increased insulin level, Hyperglycemia | Deregulated Nutrient Sensing | JZM can not reverse the forming processes of hyperglycemia, hyperinsulinemia, and insulin resistance in MSG rats. | 19213346 |
| Hyperglycemia, Dyslipidemias, Non-alcoholic Fatty Liver Disease, No metabolic abnormalities, Weight decreased | Deregulated Nutrient Sensing | Even a small weight reduction was associated with improvements in NAFLD and related metabolic abnormalities such as dyslipidemia and hyperglycemia. | 19214024 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The percentage of patients with diabetes, dyslipidemia, hypertension and left main disease increased over time (P<0.05). | 19214298 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Parental history of type 2 diabetes mellitus increases risk of not only glucose intolerance but also other cardiometabolic risk factors like overweight, low high-density lipoprotein cholesterol, and high blood pressure in Asian Indian adolescents. | 19217449 |
| Microalbuminuria, Endothelial dysfunction, Metabolic Syndrome X | Deregulated Nutrient Sensing | Microalbuminuria (MA) clusters with the metabolic syndrome and insulin resistance and may reflect endothelial dysfunction. | 19217459 |
| Obesity | Deregulated Nutrient Sensing | Usual relation between caloric intake and blood pressure in obese may be due to insulin resistance induced by obesity. | 19218718 |
| Fatty Liver | Deregulated Nutrient Sensing | In addition, the higher ALT, Homeostasis model assessment- insulin resistance (HOMA-IR), cholesterol, triglyceride, and non-HDL levels and lower HDL-C as the severity of fatty liver increased. | 19221666 |
| Inflammation, atherosclerotic | Deregulated Nutrient Sensing | The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques. | 19223085 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The value of diagnostic categories of glucose intolerance for predicting type 2 diabetes is much debated. | 19224196 |
| Glucose Intolerance (disease), Acromegaly | Deregulated Nutrient Sensing | Insulin resistance, leading to glucose intolerance is one of the most important contributory factors to the cardiovascular mortality in acromegaly. | 19224501 |
| Increased insulin level, Acromegaly | Deregulated Nutrient Sensing | In patients with acromegaly insulin resistance and hyperinsulinemia are positively correlated with the level of activity of the disease. | 19224501 |
| Refractory anemias, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Further studies are needed to elucidate molecular mechanisms of dyslipidemia in RA and to ensure the choice of optimal targets for therapeutic modalities reducing the risk of cardiovascular disorders. | 19227308 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients. | 19228823 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. | 19228823 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Truncal obesity is linked to dyslipidemia and also predicts CV mortality. | 19228823 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients. | 19228823 |
| Inflammation, Malnutrition, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. | 19228823 |
| TG gene, HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients. | 19228823 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Our results suggest that obesity and insulin resistance that accompanies obesity may influence platelet reactivity in patients with type 2 diabetes. | 19228864 |
| Inflammation, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Uremic dyslipidemia and inflammation take part in the etiology of atherosclerosis. | 19229822 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was a very high prevalence of diabetes, hypertension and dyslipidemia in the patients. | 19230422 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes. | 19230737 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Betaglucan enriched bread may contribute to the improvement of the lipid profile and insulin resistance in patients with T2D. | 19230737 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Markers of glycemic control and insulin resistance in non-diabetic patients with Obstructive Sleep Apnea Hypopnea Syndrome: does adherence to CPAP treatment improve glycemic control? | 19231280 |
| Neurodegenerative Disorders, Primary malignant neoplasm, Acne, Atherosclerosis, Diabetes Mellitus, Obesity | Deregulated Nutrient Sensing | Insulin/IGF-1 signalling is involved in the regulation of fetal growth, T-cell maturation in the thymus, linear growth, pathogenesis of acne, atherosclerosis, diabetes mellitus, obesity, cancer and neurodegenerative diseases, thus affecting most chronic diseases of Western societies. | 19232475 |
| Metabolic Diseases, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | After the first OGTT, 66 patients (75%) were found to have carbohydrate metabolism disorders (41% glucose intolerance and 34% diabetes mellitus). | 19232754 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | After the second OGTT 39 patients (44.3%) had carbohydrate metabolism disorders (26% glucose intolerance and 18% diabetes mellitus). | 19232754 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes or insulin resistance, overweight, arterial hypertension, and dyslipidaemia are recognized risk factors for cardiovascular (CV) disease. | 19237305 |
| Obesity | Deregulated Nutrient Sensing | Relative importance and conjoint effects of obesity and physical inactivity for the development of insulin resistance. | 19237994 |
| Obesity | Deregulated Nutrient Sensing | Obesity and physical inactivity are related to the development of insulin resistance, but their relative importance and conjoint effects are unclear. | 19237994 |
| Obesity | Deregulated Nutrient Sensing | Our results imply that obesity and physical inactivity may increase insulin resistance and metabolic risk by partly independent pathways, and emphasize the importance of strategies that address both obesity and physical inactivity to achieve increased public health. | 19237994 |
| Bone Diseases, Metabolic acidosis, Anemia, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension/proteinuria was managed appropriately in 72.4% of cases, anaemia in 56.2%, bone disease in 16.7%, metabolic acidosis in 60.2% and dyslipidemia in 61.4%. | 19239592 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Enrollment in PCAP was a predictor in reaching diabetic and some dyslipidemia therapeutic goals. | 19240259 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The GCKR rs780094 and GCK rs1799884 polymorphisms have been reported to be associated with dyslipidaemia and type 2 diabetes in white Europeans. | 19241058 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Consistent with observations in white Europeans, the GCKR rs780094 polymorphism contributes to the risk of type 2 diabetes and dyslipidaemia in Han Chinese individuals. | 19241058 |
| Spinal Cord Injuries | Deregulated Nutrient Sensing | Association of C-reactive protein and insulin resistance in patients with chronic spinal cord injury. | 19242618 |
| Spinal Cord Injuries | Deregulated Nutrient Sensing | To study the association between C-reactive protein levels and insulin resistance in patients with spinal cord injury. | 19242618 |
| Spinal Cord Injuries | Deregulated Nutrient Sensing | Most young and middle-aged patients with chronic spinal cord injury with high C-reactive protein levels also have high insulin resistance, and their C-reactive protein levels have well correlated with insulin resistance. | 19242618 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia and high blood pressure are both major cardiovascular disease risk factors. | 19243712 |
| Weight Gain, Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Several second-generation antipsychotic (SGA) drugs have been associated with weight gain, hyperglycemia, and dyslipidemia. | 19244091 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | More effort is needed to improve diabetes and dyslipidemia screening in these at-risk patients. | 19244091 |
| Critical Illness, Beta-cell dysfunction | Deregulated Nutrient Sensing | Our finding that beta-cell dysfunction is present in a subset of critically ill children with CIH challenges the assertion from adult studies that CIH is primarily the result of elevated insulin resistance. | 19245691 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most frequent risk factors were dyslipidemia (60%), smoking (44%), and hypertension (39%). | 19246709 |
| Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Urban Indians have a high prevalence of insulin resistance, hypertension and cardiovascular disease. | 19246794 |
| Hypertensive (finding), Glucose Intolerance (disease), Prehypertension | Deregulated Nutrient Sensing | Subjects with pre-hypertension had body mass index, waist-hip ratio and frequency of glucose intolerance, which was intermediate between normotensive and hypertensive subjects. | 19246794 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes related to mutations of the lamin A/C gene is difficult to treat because of severe insulin resistance. | 19249234 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | We randomized 16 diabetologists and 98 patients with type 2 diabetes referred to a subspecialty diabetes clinic to use the Statin Choice decision aid or a patient pamphlet about dyslipidaemia, and then to receive these materials from either the clinician during the visit or a researcher prior to the visit. | 19250151 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Overweight was observed in 49.3 % of adults, while 30.9 % were hypertensive and 44.1 % had dyslipidaemia. | 19250574 |
| Dyslipidemias | Deregulated Nutrient Sensing | Fibrates are useful in managing dyslipidaemia; reports highlight an expected increase in HDL-C of 10-15% in conjunction with falls in plasma triglycerides of approximately 30%. | 19251953 |
| Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | In adults, it is linked to cardiovascular disease, insulin resistance, and hypertension. | 19255005 |
| Carcinogenic Chlorinated Hydrocarbon, Fibrosis Assessment, Hepatitis, Chronic, Steatohepatitis | Deregulated Nutrient Sensing | Association of insulin resistance with hepatic steatosis and progression of fibrosis in Chinese patients with chronic hepatitis C. To investigate the relationships between insulin resistance, hepatic steatosis, and fibrosis in consecutive non-diabetic Chinese CHC patients with biopsy results. | 19260496 |
| Carcinogenic Chlorinated Hydrocarbon, Communicable Diseases, Fibrosis Assessment, Steatohepatitis | Deregulated Nutrient Sensing | In Chinese CHC patients, insulin resistance can occur in earlier stage of infection and closely related with hepatic steatosis and fibrosis. | 19260496 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lifestyle interventions during the phase of insulin resistance mitigate cardiovascular risk and prevent diabetes. | 19261690 |
| Obesity, Visceral, Diabetes Mellitus | Deregulated Nutrient Sensing | We investigated the associations of gamma-glutamyltransferase (GGT) with visceral obesity, adiponectin and retinol binding protein 4 (RBP4), and insulin resistance (IR) and compared these associations with other liver enzymes in non-diabetes. | 19264371 |
| Hypoxia | Deregulated Nutrient Sensing | Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. | 19265035 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | There is increasing concern that some atypical antipsychotic therapies are associated with adverse metabolic symptoms, such as weight gain, dyslipidaemia and glucose dysregulation. | 19267255 |
| diabetic | Deregulated Nutrient Sensing | Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects. | 19267279 |
| diabetic | Deregulated Nutrient Sensing | To determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects. | 19267279 |
| Dyslipidemias | Deregulated Nutrient Sensing | This is the first study to increase the adherence to multiple interventions in patients with dyslipidemia, and other CVD risk factors, in both primary care and teaching hospital settings. | 19268376 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | Weight gain was significantly greater in OLZ-treated patients, as was accentuation of dyslipidemia. | 19268968 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The patients with LMCA disease were more likely to be male, older, and have diabetes mellitus or dyslipidemia, whereas cigarette smoking was found as an independent predictor of isolated LMCA. | 19274028 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impaired oxidative capacity of skeletal muscle mitochondria contribute to insulin resistance and type 2 diabetes (T2D). | 19274082 |
| Migraine Disorders | Deregulated Nutrient Sensing | Recent studies suggest that insulin resistance is more common in patients with migraine. | 19276782 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia frequencies showed no difference between 2 groups. | 19276782 |
| Renal Insufficiency, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | It specifically addressed the hypotheses that renal dysfunction in these patients may associate with the presence of insulin resistance, dyslipidaemia, uric acid levels and/or current levels of systemic inflammation. | 19279016 |
| Renal Insufficiency, Dyslipidemias, Extra-articular, Refractory anemias | Deregulated Nutrient Sensing | Renal dysfunction in RA is quite common and associates with classic cardiovascular risk factors such as advanced age and dyslipidaemia, levels of SUA and the presence of extra-articular disease. | 19279016 |
| Dyslipidemias, Coronary Arteriosclerosis, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence rates of ischaemic heart disease, dyslipidaemia, arterial hypertension and diabetes suggest that Joinville presents a mixed pattern of cardiovascular risk, a pattern seen in developed and developing countries alike. | 19279029 |
| Arterial Stiffness, Inflammation, Endothelial dysfunction, ETV3 wt Allele | Deregulated Nutrient Sensing | How MetS increases CVD risk is incompletely understood, but increasing arterial stiffness is one candidate link, which in turn could be explained by (low-grade) inflammation, endothelial dysfunction (ED) or insulin resistance (IR). | 19279658 |
| Glaucoma, Open-Angle, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Due to the patient age, cholesterol values, as common factors in primary open-angle glaucoma and atherosclerosis genesis, could be concern in the same aetiology based on dyslipidaemia as well. | 19284402 |
| Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study. | 19284557 |
| Disease | Deregulated Nutrient Sensing | Although recent evidence suggests a link between SIRT1 activity and metabolic homeostasis during CR, its pathological role in human disease is not yet fully understood. | 19286634 |
| physiopathological, Diabetes Mellitus | Deregulated Nutrient Sensing | Likewise, activation of Sirt1 prevents the hyperglycemia-induced vascular cell senescence and thereby protects against vascular dysfunction in mice with diabetes. | 19286634 |
| Hyperglycemia, Disorder of eye due to diabetes mellitus | Deregulated Nutrient Sensing | These findings represent a novel mechanism of vascular cell senescence induced by hyperglycemia and suggest a protective role of SIRT1 in the pathogenesis of diabetic vasculopathy. | 19286634 |
| Fibrosis Assessment, Fatty degeneration, Hepatitis C | Deregulated Nutrient Sensing | Influence of insulin resistance on hepatic fibrosis and steatosis in hepatitis C virus (HCV) mono-infected compared with HIV-HCV co-infected patients. | 19292832 |
| Steatohepatitis, Fibrosis Assessment | Deregulated Nutrient Sensing | To test the association among insulin resistance (IR), liver fibrosis and liver steatosis in HIV-HCV and HCV-infected patients. | 19292832 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance was independently associated in HCV patients with fibrosis [odds ratio (OR) = 2.04 (95% CI 1.02-4)], a body mass index (BMI) >25 kg/m(2) [OR = 3.33 (1.47-7.69)] and steatosis [OR = 3.33 (1.67-6.67)]. | 19292832 |
| Fibrosis, Liver, Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance is associated with liver fibrosis and steatosis in HCV mono-infected, but not in HIV-HCV co-infected patients. | 19292832 |
| Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | After insulin withdrawal, the patient's condition markedly improved: he showed better diabetes control, decrease in insulin resistance, weight loss, reduced BMI, reduced waist circumference, sagittal abdominal diameter and body fat, increased fitness level, normalized blood pressure and decreased heart rate at rest. | 19300386 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The prevalence of selected CVRF was: hypertension: 74.5%; dyslipidemia: 77.7%; smoking: 14.9%; obesity 44.9%, and familial CVD: 38.4%. | 19302689 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The impact of dyslipidaemia on cardiovascular mortality in individuals without a prior history of diabetes in the DECODE Study. | 19303072 |
| Obesity, Visceral, Beta-cell dysfunction | Deregulated Nutrient Sensing | We studied whether genetic variation within these genes contributes to the development of disproportionate visceral obesity and obesity-related traits, such as insulin resistance and beta-cell dysfunction. | 19303973 |
| Obesity | Deregulated Nutrient Sensing | Angiopoietin-related growth factor (AGF) was recently introduced as a novel liver-derived protein that antagonizes obesity and insulin resistance. | 19303977 |
| diabetic | Deregulated Nutrient Sensing | This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with VFA and insulin resistance in type 2 diabetic patients not receiving insulin treatment. | 19320939 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results of this preliminary study indicate that the presence of WML was associated with the high VFA and insulin resistance in Japanese patients with type 2 diabetes mellitus. | 19320939 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, Haiti, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension (HT), diabetes mellitus (DM) and dyslipidemia (LIP) were defined in accordance with guidelines. | 19321325 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | The same allele associates with estimates of beta-cell dysfunction and hepatic insulin resistance. | 19324940 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Gender-associated differences in the lipid profile are evident in subjects presenting with dyslipidemia and might be of potential relevance for diagnostics and therapy for the prevention of atherosclerosis. | 19327602 |
| Glucose Intolerance (disease), Overweight | Deregulated Nutrient Sensing | Overweight or central obesity is generally associated with increases in fasting insulin levels, insulin resistance, and glucose intolerance and has been identified as a target for new therapeutic strategies, including early change in lifestyle. | 19327605 |
| Metabolic Diseases, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Results suggest that increased serum uric acid concentration is associated with an increased prevalence of metabolic disorders such as obesity, dyslipidemia and hypertension in the Hangzhou population. | 19329400 |
| Renal Insufficiency, Hypertension, CTCAE | Deregulated Nutrient Sensing | Essential hypertension is a clinical condition associated with insulin resistance and progressive impairment of renal function that increases cardiovascular events. | 19330922 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | We demonstrate a significant relationship between IGF-1 and GFR in a large sample of never treated hypertensive patients, probably as consequence of insulin resistance/hyperinsulinemia, which is a very frequent condition in high BP. | 19330922 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no association between the anti-CCP antibodies and cardiovascular risk factors such as smoking, hypertension, dyslipidemia, being overweight, or diabetes mellitus. | 19333979 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Insulin resistance has been implicated in the etiology of pancreatic cancer. | 19336549 |
| Impaired cognition | Deregulated Nutrient Sensing | Targeting insulin resistance and vascular complications-both associated with cognitive decline-may be a productive approach. | 19336640 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Twin status per se is associated with abdominal obesity, insulin resistance, and increased prevalence of type 2 diabetes in elderly twins. | 19336677 |
| Dyslipidemias, omega-3 fatty acids, Endothelial dysfunction | Deregulated Nutrient Sensing | Combined therapy with omega-3-PUFAs and rosuvastatin improves endothelial function in South Asian subjects with dyslipidemia and endothelial dysfunction. | 19337557 |
| Chromium deficiency, Dyslipidemias | Deregulated Nutrient Sensing | Chromium deficiency is associated with impaired glucose tolerance (IGT) and dyslipidemia. | 19337698 |
| Obesity | Deregulated Nutrient Sensing | Decreased activity of desaturase 5 in association with obesity and insulin resistance aggravates declining long-chain n-3 fatty acid status in Cree undergoing dietary transition. | 19338705 |
| Obesity | Deregulated Nutrient Sensing | The present study indicates that the dietary transition of reduced consumption of fish among younger Cree may compound the effects of obesity and emerging insulin resistance which, in turn, could reduce bioavailability of HUFA n-3 (through reduced Delta5 activity). | 19338705 |
| Hypertension, CTCAE, Demographics Domain, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no significant correlation of aspirin resistance with traditional risk factors like diabetes mellitus (DM), hypertension or dyslipidemia. | 19339237 |
| Acute lymphocytic leukemia | Deregulated Nutrient Sensing | Body mass index predicts insulin resistance in survivors of pediatric acute lymphoblastic leukemia. | 19340854 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | At study time, one subject had prediabetes; eight (29.6%) had insulin resistance. | 19340854 |
| Acute lymphocytic leukemia | Deregulated Nutrient Sensing | Waist/hip ratio and BMI at ALL diagnosis also correlated with insulin resistance, but these factors' effects could not be separated from BMI at study time. | 19340854 |
| Hyperglycemia, Glucose Intolerance (disease), Acute lymphocytic leukemia | Deregulated Nutrient Sensing | Variations in ALL therapy and presence of transient hyperglycemia do not appear to increase risk of glucose intolerance or insulin resistance in the first few years after completion of therapy. | 19340854 |
| Hypertension, CTCAE, Lower Urinary Tract Symptoms, Dyslipidemias | Deregulated Nutrient Sensing | Increased odds of LUTS were also observed in men undergoing medical treatment for hypertension or dyslipidemia. | 19341367 |
| Hypertension, CTCAE, Lower Urinary Tract Symptoms, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Our present findings, together with previous epidemiological and experimental evidence, suggest that LUTS might share common etiological factors with diabetes mellitus, hypertension, and dyslipidemia. | 19341367 |
| Arthralgia, Dyslipidemias, Gastroesophageal reflux disease, Sleep Apnea, CTCAE, Depression, CTCAE, Back Pain, Hernia, Urinary Stress Incontinence | Deregulated Nutrient Sensing | The analysis revealed a significantly greater prevalence and severity of dyslipidemia (P <.05), gastroesophageal reflux disease (P <.05), back pain (P <.0001), joint pain (P <.05), sleep apnea (P <.01), stress incontinence (P <.01), and hernia (P <.05) among patients with depression. | 19342306 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia remains underdiagnosed and undertreated in patients with coronary artery disease. | 19344008 |
| FAI - Free androgen index measurement, Blood Glucose | Deregulated Nutrient Sensing | Androgenicity, as measured by low sex hormone-binding globulin (SHBG) and elevations in testosterone and free androgen index (FAI), is associated with adverse cardiovascular (CV) outcomes, possibly due to effects on insulin resistance and glycemia. | 19344226 |
| Hyperglycemia | Deregulated Nutrient Sensing | Postoperative insulin resistance, resulting in hyperglycemia, is strongly associated to morbidity and mortality in surgical patients but the underlying mechanisms are unclear. | 19346035 |
| Inflammation | Deregulated Nutrient Sensing | As increasing data suggests a link between inflammation and insulin resistance, we aimed to evaluate if the expression of inflammatory and insulin signaling genes is regulated in skeletal muscle during surgery. | 19346035 |
| Inflammation | Deregulated Nutrient Sensing | The observed gene expression changes in skeletal muscle during surgery occurred mainly in inflammatory pathways, suggesting a possible role for inflammation in the development of postoperative insulin resistance. | 19346035 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | An Ask1-MKK4-p38MAPK/JNK pathway reflects adipocyte stress associated with adipose tissue inflammation, linking visceral adiposity to whole-body insulin resistance in obesity. | 19351724 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The extraskeletal effects of PTH, such as insulin resistance, arterial hypertension, and cardiovascular (CV) risk, may however be reversible by operation. | 19351725 |
| Inflammation | Deregulated Nutrient Sensing | No significant differences were observed between the groups for blood pressure, markers of insulin resistance, detailed cholesterol metabolism, adipokines, or parameters of inflammation and CV surrogate markers. | 19351725 |
| Dyslipidemias | Deregulated Nutrient Sensing | Levels of inflammatory markers and their correlation with dyslipidemia in diabetics. | 19356332 |
| Dyslipidemias | Deregulated Nutrient Sensing | To measure the levels of inflammatory markers (serum ferritin and high sensitivity C-reactive protein) and dyslipidemia in diabetics and to find a correlation between these inflammatory markers and dyslipidemia. | 19356332 |
| Inflammation, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Low-grade inflammation exists in Diabetes mellitus and it is positively related with dyslipidemia (except for HDL cholesterol) in diabetics. | 19356332 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | When compared with control subjects, the EMT was increased in both the diabetes (p < 0.0001) and dyslipidemia (p = 0.04) groups. | 19356553 |
| Metabolic Diseases, Demographics Domain, Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and dyslipidemia. | 19360107 |
| Coronary Arteriosclerosis, Coronary Artery Disease, diabetic | Deregulated Nutrient Sensing | Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease. | 19361872 |
| Traumatic injury | Deregulated Nutrient Sensing | Preoperative fasting of 2 hours minimizes insulin resistance and organic response to trauma after video-cholecystectomy: a randomized, controlled, clinical trial. | 19363695 |
| Traumatic injury | Deregulated Nutrient Sensing | We investigated the influence of a carbohydrate-rich drink given 2 h before laparoscopic cholecystectomy on insulin resistance and the metabolic response to trauma. | 19363695 |
| Traumatic injury | Deregulated Nutrient Sensing | Abbreviation of the period of preoperative fasting and administration of a carbohydrate beverage diminishes insulin resistance and the organic response to trauma. | 19363695 |
| Neoplasms | Deregulated Nutrient Sensing | Overall, our experiments identify a c-Myc-SIRT1 feedback loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of SIRT1 in tumor suppression. | 19364925 |
| dysmetabolic syndrome, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Coronary heart disease | Deregulated Nutrient Sensing | The metabolic syndrome (also known as syndrome X, insulin resistance syndrome, dysmetabolic syndrome, deadly quartet and plurimetabolic syndrome) is a cluster of factors associated with increased risk of developing coronary heart disease and/or type 2 diabetes. | 19366079 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Vitamin D deficiency is common in the middle-aged and elderly Chinese population, and a low 25(OH)D level is significantly associated with an increased risk of having metabolic syndrome and insulin resistance. | 19366976 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Little information is available on the relation between insulin resistance and acute myocardial infarction. | 19367169 |
| Obesity | Deregulated Nutrient Sensing | Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. | 19368945 |
| Obesity | Deregulated Nutrient Sensing | We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. | 19368945 |
| long-chain fatty acid binding | Deregulated Nutrient Sensing | Inefficient muscle long-chain fatty acid (LCFA) combustion is associated with insulin resistance, but molecular links between mitochondrial fat catabolism and insulin action remain controversial. | 19369366 |
| Metabolic Diseases | Deregulated Nutrient Sensing | In our population, RBP4 circulating levels were not significantly correlated with obesity-related parameters, although a tendency to correlate with waist circumference suggests a relationship with insulin resistance and other metabolic disorders. | 19369430 |
| Hypertension, CTCAE, Dyslipidemias, Prediabetes syndrome | Deregulated Nutrient Sensing | There are increased constellation of other cardiovascular risk factors (hypertension, dyslipidaemia, etc), in prediabetes as compared to normal population. | 19370946 |
| Inflammation, Hypertrophy | Deregulated Nutrient Sensing | Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. | 19372460 |
| Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients. | 19373236 |
| Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | However, few echocardiographic studies have assessed the relations of insulin resistance and obesity to LA size in hypertensive patients. | 19373236 |
| Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | We enrolled 106 never-treated hypertensive patients (57 men and 49 women) to assess the possible relations of insulin resistance and obesity to LA size. | 19373236 |
| Dyslipidemias, Lipid Metabolism Disorders | Deregulated Nutrient Sensing | Dyslipidemia and the treatment of lipid disorders in African Americans. | 19375555 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Despite the high prevalence of cardiovascular disease documented among the African-American population, there has been little emphasis on the role of dyslipidemia as a prominent risk factor in this large subpopulation. | 19375555 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was defined as the presence of either hypercholesterolemia or hypertriglyceridemia using National Cholesterol Education Program III criteria and the fasting lipid measurements, self-reported treatment history, and medication survey available from 5302 Jackson Heart Study participants. | 19375555 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To assess whether an increased genetic predisposition for type 2 diabetes mellitus (T2DM) influences the contributions of insulin resistance and impaired insulin secretion to impaired glucose tolerance (IGT), 437 subjects not known to have T2DM underwent an oral glucose tolerance test and a 3-hour hyperglycemic clamp. | 19375581 |
| Obesity | Deregulated Nutrient Sensing | Adjustment for obesity abolished the differences in insulin resistance but not plasma insulin responses. | 19375581 |
| Diabetes Mellitus, Non-Insulin-Dependent, Autonomic nervous system disorders | Deregulated Nutrient Sensing | This preliminary study was therefore designed to test the hypothesis that WML is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetes mellitus patients without insulin treatment. | 19375594 |
| Depressed mood, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results suggested that WML was associated with depressed cardiovascular autonomic function and insulin resistance and that HOMA index and the percentage WR of (123)I-MIBG were independent associations for WML in Japanese patients with type 2 diabetes mellitus. | 19375594 |
| Calcification of coronary artery | Deregulated Nutrient Sensing | Insulin resistance independently predicts the progression of coronary artery calcification. | 19376325 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Insulin resistance, in addition to the traditional cardiac risk factors, independently predicts progression of CAC in a community-based population without clinical CAD. | 19376325 |
| Cerebral atrophy, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the impact of insulin resistance short of diabetes on the arteriolar-to-venular ratio (AVR) and whether AVR is related to cerebral atrophy. | 19376581 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | These novel findings indicate that insulin resistance short of diabetes and independent of age and hypertension has a negative impact on retinal vessel health. | 19376581 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. | 19377286 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | More than half of these adolescents with nonoptimal blood pressure values had additional cardiovascular risk factors (overweight defined as body mass index >or=90th percentile for sex and age, dyslipidaemia defined as total cholesterol >5.0 mmol/l or high-density lipoprotein cholesterol less than 1.0 mmol/l or smoking). | 19378395 |
| Hepatitis C, Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus. | 19382270 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | One-third of patients had abnormal glycaemia, hypertension and dyslipidaemia concurrently. | 19383060 |
| Dyslipidemias, Cardiovascular Diseases, diabetic | Deregulated Nutrient Sensing | Forty-seven patients were smokers (6%), 90 (13%) had a personal history of cardiovascular disease, 42 (6%) were diabetic, 255 (37%) had dyslipidemia, and 31 (5%) were both diabetic and dyslipidemic. | 19388489 |
| No metabolic abnormalities, Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Both obesity and aging increase intrahepatic fat (IHF) content, which leads to nonalcoholic fatty liver disease (NAFLD) and metabolic abnormalities such as insulin resistance. | 19390517 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Plasma adiponectin levels are difficult to interpret in the setting of CKD because of multiple confounders that may influence the relationship between adiponectin, adiposity, and insulin resistance. | 19393918 |
| TG gene, Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The association between 'metabolic dyslipidemia' as defined by high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels and the risk of coronary heart disease (CHD) risk is not known. | 19394708 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Metabolic dyslipidemia was defined by combination of increased triglyceride (TG) levels (>=150 mg/dl) and low high-density lipoprotein cholesterol (HDL-C) levels (<=50 mg/dl for women and <=40 mg/dl for men). | 19394708 |
| TG gene, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Compared to men with normal HDL and normal TG, men with metabolic dyslipidemia had an increased risk for CHD (HR 1.61, 95% CI 1.40-1.86). | 19394708 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Among women, metabolic dyslipidemia was associated with increased CHD risk (HR 1.78, 95% CI 1.47-2.15). | 19394708 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Metabolic dyslipidemia is associated with an increased risk of CHD. | 19394708 |
| Schizophrenia | Deregulated Nutrient Sensing | We studied the expression of IDE protein in postmortem brains of patients with schizophrenia and controls because: (1) the gene encoding IDE is located on chromosome 10q23-q25, a gene locus linked to schizophrenia; (2) insulin resistance with brain insulin receptor deficits/receptor dysfunction was reported in schizophrenia; (3) the enzyme cleaves IGF-I and IGF-II which are implicated in the pathophysiology of the disease; and (4) brain gamma-endorphin levels, liberated from beta-endorphin exclusively by IDE, have been reported to be altered in schizophrenia. | 19394958 |
| Dyslipidemias, Nephrotic Syndrome | Deregulated Nutrient Sensing | Dyslipidemia contributes to increased cardiovascular risk in nephrotic syndrome. | 19397474 |
| Hyperlipidemia, Glucose Intolerance (disease), Hepatitis C | Deregulated Nutrient Sensing | Glucose intolerance has been associated with HCV infection and treating hyperlipidemia in this and other high-risk groups is warranted. | 19398918 |
| Hyperglycemia | Deregulated Nutrient Sensing | Patients may develop hyperglycemia due to a combination of surgical stress and postoperative insulin resistance. | 19399583 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Understanding the role of insulin resistance in type 1 diabetes may lead to new prevention strategies. | 19401372 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Estimates of insulin resistance in first-degree relatives of those with type 1 diabetes may be obtained using the minimal model of glucose kinetics incorporating a population approach. | 19401372 |
| Diego blood group system | Deregulated Nutrient Sensing | The increase IGI(30) was apparently insufficient to compensate for the insulin resistance because DI decreased linearly at the rate of 0.035 (10(-2) min(-1) mmol(-1) liter per year) after young adulthood. | 19401372 |
| Obesity | Deregulated Nutrient Sensing | Physical inactivity and obesity underlie the insulin resistance of aging. | 19401446 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | OBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2 diabetes in older adults. | 19401446 |
| Obesity | Deregulated Nutrient Sensing | We examined a corollary hypothesis that obesity and level of chronic physical inactivity are the true causes for this ostensible effect of aging on insulin resistance. | 19401446 |
| Obesity | Deregulated Nutrient Sensing | CONCLUSIONS Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity. | 19401446 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Fasting triglyceride (TG) concentrations are an unreliable index of fructose-induced dyslipidemia. | 19403712 |
| Atherosclerosis | Deregulated Nutrient Sensing | Also, adipocyte-derived protein adiponectin, especially its high molecular weight (HMW) form, has been reported to have beneficial effects on insulin resistance and atherosclerosis. | 19403983 |
| ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | In addition to insulin resistance and obesity, baPWV was strongly related to MetS in middle-aged Taiwan Chinese. | 19403990 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Older age, higher body mass index, male gender, diabetes, hypertension and dyslipidaemia all increased the likelihood of the CAP burden at univariable analysis (p<0.001). | 19406736 |
| Pancreatitis, Dyslipidemias | Deregulated Nutrient Sensing | The relationship between pancreatitis and dyslipidaemia is unclear. | 19407479 |
| Unknown (origin) (qualifier value), Pancreatitis, Dyslipidemias, Biliary calculi | Deregulated Nutrient Sensing | The pancreatitis was associated with alcohol (63%), gallstones (18%), idiopathic (9%) and isolated dyslipidaemia (10%). | 19407479 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was significantly different between the two predominant race groups: Indian 50.5% and African 17.9% (p < 0.000017). | 19407479 |
| Dyslipidemias | Deregulated Nutrient Sensing | Seventy-eight (34%) had associated dyslipidaemia and 152 (66%) were normolipaemic at admission. | 19407479 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Adverse outcomes in those with dyslipidaemia were predominantly associated with hypertriglyceridaemia. | 19407479 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Single-pill amlodipine/atorvastatin targets the two most common modifiable cardiovascular risk factors, hypertension and dyslipidaemia. | 19407658 |
| Dyslipidemias, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Study of the relationship between carotid intima-media thickness and traditional Chinese medicine syndrome of dyslipidemia. | 19407948 |
| Dyslipidemias, Upper respiratory tract mucus, Blood Stasis | Deregulated Nutrient Sensing | According to the theory of the TCM syndrome, 152 dyslipidemia patients were assigned to 4 groups: the stagnation of phlegm (SP) group, the blood stasis blocking channels (BSBC) group, the stagnation of phlegm and blood (SPB) group and the non-stagnation of phlegm and blood (NSPB) group. | 19407948 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Carotid IMT, TG and blood rheology were closely correlated with the TCM syndrome of dyslipidemia. | 19407948 |
| Apolipoproteins, Dyslipidemias | Deregulated Nutrient Sensing | Visceral fat is better associated than fat mass with atherogenic dyslipidemia and, in men, with apolipoprotein B. | 19411085 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension was documented in 577 (92.2%) patients, dyslipidemia in 266 (42.5%) and mortality from all causes in 86 (13.7%). | 19414942 |
| Hyperhomocysteinemia, Dyslipidemias | Deregulated Nutrient Sensing | Further tests found out dyslipidemia, hyperhomocysteinemia, impaired glucose tolerance. | 19415447 |
| Glucose Intolerance (disease), Hepatitis C | Deregulated Nutrient Sensing | Patients with hepatitis C virus (HCV) frequently show glucose intolerance. | 19422477 |
| Glucose Intolerance (disease), Hepatocarcinogenesis, FAM126A gene | Deregulated Nutrient Sensing | They were also screened for HCC and, thereafter, the rate of hepatocarcinogenesis was compared between the patients with and without glucose intolerance. | 19422477 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Among Asians, including Japanese, obesity is related to dyslipidemia and insulin resistance at a lower level of body mass index (BMI) compared with non-Hispanic whites (NHW). | 19428036 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. | 19430421 |
| Primary malignant neoplasm, Obesity | Deregulated Nutrient Sensing | In addition, SIRT1 may be involved in the well-known link between obesity, cellular energy balance and cancer. | 19430421 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | However, a comprehensive study of SIRT1 using human cancer tissue with clinical outcome data is currently lacking, and its prognostic significance is uncertain. | 19430421 |
| Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Using the database of 485 colorectal cancers in two independent prospective cohort studies, we detected SIRT1 overexpression in 180 (37%) tumors by immunohistochemistry. | 19430421 |
| Neoplasms | Deregulated Nutrient Sensing | SIRT1 was not significantly related with age, sex, tumor location, stage, signet ring cells, cyclooxygenase-2 (COX-2), LINE-1 hypomethylation, KRAS, BRAF, BMI, PIK3CA, HDAC, p53, beta-catenin, COX-2, or patient prognosis. | 19430421 |
| Neoplasms | Deregulated Nutrient Sensing | In conclusion, SIRT1 expression is associated with CIMP-high MSI-high colon cancer, suggesting involvement of SIRT1 in gene silencing in this unique tumor subtype. | 19430421 |
| Glucose Intolerance (disease), Hypertension, CTCAE, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Of the 338 cases, 32 people had diabetes (DM, 9.46%), 78 people had glucose intolerance (IGT, 23.1%), and 228 people had only hypertension but not IGT and DM (67.4%). | 19430550 |
| Dyslipidemias, Cerebrovascular accident, Coronary heart disease, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Information on CVD/CVD risk factors (coronary heart disease, cerebrovascular accident, diabetes, hypertension or dyslipidemia) was self-reported. | 19432034 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. | 19433800 |
| Hypertensive disease, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | It appears that all classical risk factors (HBP, Diabetes, obesity, tobacco use, sedentary, menopause, contraceptives, dyslipidemia) were found among patients. | 19434980 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Such alterations were not observed in group C. It appears that dietetic supplementation with coconut oil does not cause dyslipidemia and seems to promote a reduction in abdominal obesity. | 19437058 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The asymptomatic subjects without CAD formed Group A, and were subdivided into A1 (without hypertension, dyslipidemia and/or diabetes) and A2 (with hypertension, dyslipidemia and/or diabetes). | 19438151 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The coronary patients formed Group B, who were also subdivided into B1, without these classic risk factors, and B2 with hypertension, dyslipidemia and/or diabetes. | 19438151 |
| Lichen Planus, Dyslipidemias | Deregulated Nutrient Sensing | Lichen planus and dyslipidaemia: a case-control study. | 19438850 |
| Dyslipidemias, Psoriasis | Deregulated Nutrient Sensing | Previous reports have demonstrated an association between psoriasis and dyslipidaemia. | 19438850 |
| Lichen Planus, Dyslipidemias, Inflammatory disorder | Deregulated Nutrient Sensing | As lichen planus (LP) is also a chronic inflammatory disorder, we investigated the association between LP and dyslipidaemia in Israel. | 19438850 |
| Dyslipidemias | Deregulated Nutrient Sensing | In the present study, LP was found to be associated with dyslipidaemia. | 19438850 |
| Atherosclerosis | Deregulated Nutrient Sensing | We investigated the relative contributions of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. | 19439511 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia was detected in 73% of the CHD subjects vs. 46% of the non-CHD ones (p = 0.00001); its severity differing regionally. | 19441674 |
| Inflammation, Prediabetes syndrome | Deregulated Nutrient Sensing | Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population. | 19442860 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Partial splenic embolization reverses insulin resistance in patients with liver cirrhosis. | 19443968 |
| Liver Cirrhosis, Diabetes Mellitus | Deregulated Nutrient Sensing | It is well known that patients with liver cirrhosis often develop insulin resistance and diabetes mellitus. | 19443968 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Conclusion PSE significantly reverses insulin resistance in patients with liver cirrhosis. | 19443968 |
| Atherosclerosis | Deregulated Nutrient Sensing | The data source for this study is the Insulin Resistance Atherosclerosis Family Study (IRASFS), which consists of Hispanic- and African-American families from three US recruitment centers (n =1,334). | 19444222 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance, histologic features of fatty liver disease, and weight change were associated with outcomes of chronic hepatitis C. Improvement in these weight-related factors might modify disease progression. | 19445938 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, not only improves insulin resistance and glycemic control, but may also have additional beneficial vascular effects in patients with type 2 diabetes mellitus. | 19446110 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Cardiovascular risk factors (CVRFs) such as high blood pressure, hyperglycemia, and dyslipidemia were estimated in each group. | 19446112 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | As might be expected, the prevalences of high blood pressure, hyperglycemia, and dyslipidemia were lowest in group 1 and were highest in group 4. | 19446112 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Model-based simulation to explore the cost-effectiveness of following practice guidelines for triglyceride and low-density lipoprotein cholesterol control among patients with diabetes mellitus and mixed dyslipidemia. | 19446159 |
| Dyslipidemias, Demographics Domain, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The results of this model simulation suggest that for patients with DM and mixed dyslipidemia, following treatment guidelines rather than current practice (including combination therapy rather than monotherapy) would result in more patients achieving lipid targets, fewer CHD events, and more QALYs gained at a reasonable cost (less than $109,000) per QALY. | 19446159 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Among the cardiovascular risk factors taken into account, only glucose intolerance and, to a lesser extent, obesity, were associated with worse performance in stabilometric tests, independent of age and sex. | 19448385 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia treatment of patients with diabetes mellitus in a US managed care plan: a retrospective database analysis. | 19450274 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | To evaluate real-world pharmacologic treatment of mixed dyslipidemia in patients with diabetes mellitus (DM). | 19450274 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | DM patients (N = 53,679) with mixed dyslipidemia were defined as having any 2 suboptimal lipid parameters (N = 28,728). | 19450274 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | Over 40% of DM patients with mixed dyslipidemia received no lipid-modifying therapy during the follow-up period. | 19450274 |
| Traumatic injury | Deregulated Nutrient Sensing | Surgical trauma causes stress and inflammatory reactions with elevated serum free fatty acids (FFA) and glucose levels characteristic of intraoperative insulin resistance. | 19454546 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Atherosclerosis | Deregulated Nutrient Sensing | Centralized adiposity, insulin resistance, excess iron, and elevated oxidative stress place postmenopausal women at risk for atherosclerotic cardiovascular disease (CVD). | 19456248 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The objective was to assess whether high energy supplementation in nondiabetic hemodialysis patients might adversely affect insulin resistance -- a known risk factor for cardiovascular disease. | 19458017 |
| Inflammation | Deregulated Nutrient Sensing | High energy supplementation, because it increases adiposity and inflammation, exacerbates insulin resistance. | 19458017 |
| Weight Gain, Hypertension, CTCAE, Posttransplant diabetes mellitus, Dyslipidemias | Deregulated Nutrient Sensing | Main CVR factors analyzed were: hypertension, dyslipidemia, posttransplant diabetes mellitus, and weight gain. | 19460509 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | It has been demonstrated that insulin resistance is associated with morning hypertension. | 19462498 |
| Hypertension, CTCAE, ciliary vesicle, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | On multivariate analysis, increased IMT was significantly and independently associated with hypertension, dyslipidemia, obesity, family history of CV disease, and age. | 19463515 |
| Inflammation, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | T2DM is associated with obesity, hypertension, dyslipidemia, hypothalamic pituitary adrenocortical (HPA) axis abnormalities and inflammation, all of which have been shown to negatively impact the brain. | 19463794 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Diminished cortisol suppression after dexamethasone and dyslipidemia were associated with decreased cognitive performance, whereas obesity was negatively related to hippocampal volume. | 19463794 |
| Albrights hereditary osteodystrophy", Hypocalcemia, Hypothyroidism, Somatotropin deficiency | Deregulated Nutrient Sensing | Pseudohypoparathyroidism type 1a in a patient with Albright hereditary osteodystrophy, characterized by hypocalcemia, hypothyroidism, growth-hormone deficiency and insulin resistance.Management. | 19465898 |
| Ischemic myocardial dysfunction | Deregulated Nutrient Sensing | B-type natriuretic peptide levels and insulin resistance in patients with severe ischemic myocardial dysfunction. | 19468263 |
| Dyslipidemias, Fatty degeneration, Diabetes Mellitus, Hepatitis B, Obesity | Deregulated Nutrient Sensing | In the group of chronic hepatitis B with steatosis, the prevalence of obesity, diabetes mellitus, dyslipidaemia, alcoholic consumption, the BMI, cholesterol, triglyceride, UA and FSG levels were significantly higher than those in the group without steatosis (P < 0.01). | 19469163 |
| Adenoma of large intestine | Deregulated Nutrient Sensing | Noninvasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. | 19470793 |
| Dyslipidemias, Haiti, Diabetes Mellitus | Deregulated Nutrient Sensing | None of HT, dyslipidemia, and cigarette smoking was a significant risk factor for ED after adjusted for age and duration of diabetes. | 19473477 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Coronary heart disease and dyslipidemia: a cross-sectional evaluation of prevalence, current treatment, and clinical control in a large cohort of Spanish high-risk patients: the PRINCEPS study. | 19476579 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with type 2 diabetes (T2DM) typically exhibit a pattern of dyslipidemia with high triglycerides, low HDL cholesterol, and small LDL particles. | 19477539 |
| Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Third national Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) in Iran: methods and results on prevalence of diabetes, hypertension, obesity, central obesity, and dyslipidemia. | 19480675 |
| Hypertriglyceridemia, Obesity | Deregulated Nutrient Sensing | LDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress. | 19481310 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Forty-one participants with impaired insulin function (IIF), ranging from insulin resistance to type 2 diabetes mellitus (T2DM), were matched with 41 healthy controls on gender, age, education, and IQ. | 19481324 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Single nucleotide polymorphisms (SNPs) of the adiponectin gene have been reported to be associated with insulin resistance and the prevalence of type-2 diabetes. | 19484180 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Adiponectin SNP sites were investigated at +45 of exon 2 and at +276 of intron 2; these sites have been thought to be associated with diabetes or insulin resistance. | 19484180 |
| Fibrosis, Liver, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Adiponectin SNPs were found to be associated with the progression of liver fibrosis and insulin resistance, suggesting that adiponectin SNPs might play roles in the occurrence and progression of NAFLD. | 19484180 |
| Dyslipidemias, Biliary calculi, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Gallstone heredity, dyslipidaemia, type 2 diabetes mellitus and metabolic syndrome increased the risk for GD in controls vs HCV patients. | 19486279 |
| Hepatobiliary Disorder, Fibrosis Assessment | Deregulated Nutrient Sensing | Its relation to hepatic fibrosis and insulin resistance in post-hepatitis liver disease is not clear. | 19486470 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | As fibrosis did not correlate with insulin resistance (r = 0.081, P = 0.204), the correlation between total adiponectin and fibrosis was not mediated by insulin resistance. | 19486470 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | We can conclude that total adiponectin level, in HCV genotype 4 patients, increases with progression of hepatic fibrosis regardless of insulin resistance. | 19486470 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Adherence to the DASH Diet is inversely associated with incidence of type 2 diabetes: the insulin resistance atherosclerosis study. | 19487638 |
| Atherosclerosis | Deregulated Nutrient Sensing | Five-year change in visceral adipose tissue quantity in a minority cohort: the Insulin Resistance Atherosclerosis Study (IRAS) family study. | 19487643 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | However, the finding of low prevalence of obesity and dyslipidemia at the onset of illness suggests that the increased frequency of these abnormalities in patients is an effect of their antipsychotic medication. | 19497246 |
| Failure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Both large neutral amino acids and fatty acids were related to an appropriate pancreatic response, suggesting that these metabolic intermediates might play a role in the progression to type 2 diabetes, one by contributing to insulin resistance and the other to pancreatic failure. | 19502541 |
| Myotonic Dystrophy | Deregulated Nutrient Sensing | Insulin resistance is mainly present in skeletal muscle in non-obese patients with myotonic dystrophy. | 19506327 |
| palladium | Deregulated Nutrient Sensing | beta-Cell function is maintained after a PD, whereas the improvement of insulin resistance may cause a short-term transient improvement of the glucose metabolism after the operation. | 19506534 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Recent data on the management of cardiovascular risk factors in high risk patients showed that dyslipidemia is still treated in an inadequate way, especially in diabetic patients. | 19506537 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increased retinol-binding protein 4 (RBP4) has been reported in association with insulin resistance and type 2 diabetes. | 19506831 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | RBP4 was associated with a higher risk for impaired glucose regulation (OR 1.011 for each 1 microg/ml increase in RBP4, 95% CI 1.000-1.022, p = 0.04) after adjustment for sex, age, BMI, current smoking and alcohol intake, family history of diabetes, insulin resistance, triacylglycerol, total cholesterol, and HDL- and LDL-cholesterol; the corresponding OR of combined impaired glucose regulation and type 2 diabetes was 1.022 (95% CI 1.009-1.035, p = 0.0009). | 19506831 |
| Diabetes Mellitus, Non-Insulin-Dependent, Smoking, Diabetes Mellitus | Deregulated Nutrient Sensing | Smoking is an independent risk factor for type 2 diabetes mellitus and showed synergistic interaction with the status of low insulin secretion and high insulin resistance for developing diabetes. | 19508609 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. | 19509139 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | SIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers. | 19509139 |
| Stomach Carcinoma, Breast Carcinoma | Deregulated Nutrient Sensing | We therefore investigated the expression levels of SIRT1 and its negative regulator, DBC1 (deleted in breast cancer 1), in gastric cancer patients. | 19509139 |
| Stomach Carcinoma, Neoplasms | Deregulated Nutrient Sensing | We evaluated immunohistochemical expression of DBC1, SIRT1, and p53 using 3-mm tumor cores from 177 gastric cancer patients for tissue microarray. | 19509139 |
| Neoplasm Metastasis, Neoplasms, Venous Invasion | Deregulated Nutrient Sensing | Expression of DBC1 was significantly correlated with tumor stage (P = 0.007), lymph node metastasis (P < 0.001), tumor invasion (P = 0.001), venous invasion (P = 0.001), histologic types (P < 0.001), p53 expression (P < 0.001), and SIRT1 expression (P < 0.001). | 19509139 |
| Neoplasm Metastasis, Neoplasms | Deregulated Nutrient Sensing | SIRT1 expression was also significantly correlated with tumor stage (P < 0.001), lymph node metastasis (P < 0.001), tumor invasion (P < 0.001), histologic types (P < 0.001), and p53 expression (P = 0.001). | 19509139 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | This study shows that expression of DBC1 and SIRT1 is a significant prognostic indicator for gastric carcinoma patients. | 19509139 |
| Chronic disease | Deregulated Nutrient Sensing | Permanent impairment of insulin resistance from pregnancy to adulthood: the primary basic risk factor of chronic Western diseases. | 19515499 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Waist circumference cutoffs were higher for women than men for hypertension, diabetes mellitus, and dyslipidemia. | 19526180 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Failure (biologic function) | Deregulated Nutrient Sensing | Factors significantly associated with an increased risk of failure to achieve goals were obesity, dyslipidemia, family histories of diabetes mellitus or hypertension, and number of antihypertensive drugs used. | 19527324 |
| diabetic | Deregulated Nutrient Sensing | In all diabetic patients, multiple regression analysis showed that HbA1c, fasting insulin, and homeostasis model assessment-insulin resistance index were independently associated with plasma FGF-21 levels. | 19528204 |
| Myalgia, Dyslipidemias | Deregulated Nutrient Sensing | 62 patients with dyslipidemia and history of discontinuation of statin therapy due to myalgias. | 19528562 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and type 2 diabetes are associated with elevated intramyocellular lipids (IMCLs) and insulin resistance. | 19531593 |
| Weight decreased | Deregulated Nutrient Sensing | Despite greater weight loss in the hypocaloric group (-7.7 +/- 0.5 vs. -3.3 +/- 0.7%, P < 0.001), FFA-induced peripheral insulin resistance was improved equally in both groups. | 19531640 |
| Weight decreased | Deregulated Nutrient Sensing | We conclude that the exercise-induced improvement in FFA-induced insulin resistance is independent of the magnitude of weight loss and FFA turnover, yet it is linked to increased intracellular FFA utilization. | 19531640 |
| Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | Pitavastatin significantly improved fasting and postprandial dyslipidemia and endothelial dysfunction in CAD patients, partly via reducing oxidative stress and increasing plasma adiponectin, although rheological parameters remained unchanged. | 19531904 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Although g/g homozygotes are diabetes prone, improvement of the insulin resistance by restricting the intakes of both carbohydrate-rich foods and cane sugar may be easier in g/g than in t/g and t/t. | 19533865 |
| Immature, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among blacks, dyslipidemia, diabetes, and smoking were independently associated with premature CAD. | 19534020 |
| Immature, Dyslipidemias | Deregulated Nutrient Sensing | Among Hispanics, dyslipidemia, male sex, and family history of CAD were independently associated with premature CAD. | 19534020 |
| muscle mass | Deregulated Nutrient Sensing | Skeletal muscles are responsible for approximately 75% of insulin stimulated whole body glucose disposal and therefore insulin resistance could underlie the relation between muscle mass and CVD. | 19535078 |
| muscle mass | Deregulated Nutrient Sensing | We aimed to determine whether muscle mass, as reflected by 24h urinary creatinine excretion, is associated with CVD and whether this depends on insulin resistance. | 19535078 |
| Atherosclerosis | Deregulated Nutrient Sensing | Contribution of subcutaneous fat accumulation to insulin resistance and atherosclerosis in haemodialysis patients. | 19535435 |
| Atherosclerosis | Deregulated Nutrient Sensing | Whereas visceral fat accumulation (VFA) is related to insulin resistance and atherosclerosis in both haemodialysis (HD) patients and the general population, little is known about the role of subcutaneous fat accumulation (SFA). | 19535435 |
| HD Term Type, Atherosclerosis | Deregulated Nutrient Sensing | It appears that there is a close relationship between SFA and insulin resistance or atherosclerosis in HD patients. | 19535435 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effect of ABCA1 variant on atherogenic dyslipidaemia in patients with Type 2 diabetes treated with rosiglitazone. | 19538231 |
| Fibrosis Assessment, Insulin | Deregulated Nutrient Sensing | Although cystic fibrosis-related diabetes (CFRD), a poor prognostic factor in cystic fibrosis (CF), is characterized by insulinopenia, the role of insulin resistance is unclear. | 19538232 |
| Cystic Fibrosis Pulmonary Exacerbation | Deregulated Nutrient Sensing | CFRD is characterized by qualitative and quantitative defects in insulin secretion, but not insulin resistance, and is associated with increased hospital admissions for pulmonary exacerbations. | 19538232 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In men without previously diagnosed diabetes, fasting insulin (P = 0.035), 2-h glucose concentrations (P = 0.028) and insulin resistance (P = 0.032) were significantly associated with HAD-D scores. | 19538241 |
| Ischemia | Deregulated Nutrient Sensing | In short-term studies, testosterone replacement therapy has been shown to protect male subjects from exercise-induced ischaemia and modify cardiovascular risk factors such as insulin resistance, fat mass and lipid profiles. | 19542238 |
| Critical Illness | Deregulated Nutrient Sensing | Blood glucose levels and insulin resistance in critically ill patients on admission to intensive care units (ICUs) have been identified as factors influencing mortality. | 19545363 |
| Critical Illness | Deregulated Nutrient Sensing | The pathogenesis of insulin resistance (IR) in critically ill patients is complex and not fully understood. | 19545363 |
| Critical Illness, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | In non-critically ill patients, resistin was found to be related to impaired glucose tolerance, insulin resistance, metabolic syndrome, obesity and type 2 diabetes. | 19545363 |
| Inflammation, Critical Illness | Deregulated Nutrient Sensing | Therefore, resistin might represent a link between inflammation, acute phase response and insulin resistance in critically ill patients. | 19545363 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | We observed a high prevalence of chronic kidney disease, hypertension, dyslipidemia, and obesity among renal transplant patients. | 19545697 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | [Cardiovascular risk markers in polycystic ovary syndrome in women with and without insulin resistance]. | 19547885 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Similarly, it is unknown whether stress hyperglycaemia predicts future glucose intolerance. | 19549250 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | lower cortisol), hyperglycaemia is more likely to reflect underlying glucose intolerance. | 19549250 |
| Diabetic Nephropathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It could be concluded that atorvastatin with its pleiotropic effects could provide optimal therapeutic intervention to control not only dyslipidemia, but also oxidative stress status with consequent improvement in the course of type 2 diabetes and diabetic nephropathy. | 19553142 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | A role for this enzyme in combating glucose intolerance was further supported by the finding that CrAT overexpression in primary human skeletal myocytes increased glucose uptake and attenuated lipid-induced suppression of glucose oxidation. | 19553674 |
| Proteinuria, Microscopic hematuria, Dyslipidemias, Hypertensive (finding) | Deregulated Nutrient Sensing | The latter hypothesis is supported by evidence that (a) NAS and IN share a relative aspecificity in their clinical symptoms (low proteinuria, microhematuria, high blood pressure, dyslipidemia) and histopathological features (as determined in the few cases that undergo a kidney biopsy), and (b) there is a high likelihood that atheromatous and hypertensive lesions coexist in the same patient. | 19554527 |
| Dyslipidemias | Deregulated Nutrient Sensing | The present study suggested that screening for elevated s-CK levels in initially healthy Japanese subjects was useful to predict first-ever MI in the future, especially in subjects with dyslipidaemia. | 19556328 |
| Sepsis, Hyperglycemia | Deregulated Nutrient Sensing | Insulin resistance and hyperglycaemia are common in severe sepsis. | 19556617 |
| Sepsis, Hyperglycemia | Deregulated Nutrient Sensing | A common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis. | 19556617 |
| Prediabetes syndrome, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Costs for subjects with diabetes plus weight risk, dyslipidemia, and hypertension were almost double the costs for subjects with prediabetes plus similar risk factors ($8,067 vs. $4,638). | 19558267 |
| Myocardial Ischemia, Cerebrovascular accident | Deregulated Nutrient Sensing | Is insulin resistance related to recurrence of stroke or incident of ischemic heart disease in patients with stroke? | 19560684 |
| Myocardial Ischemia, Atherosclerosis, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance promotes atherosclerosis and has been recognized as an important risk factor for both stroke and ischemic heart disease (IHD). | 19560684 |
| Myocardial Ischemia, Ischemic stroke | Deregulated Nutrient Sensing | However, the precise relationship between insulin resistance and ischemic stroke recurrence or development of IHD is uncertain. | 19560684 |
| Myocardial Ischemia, Ischemic stroke | Deregulated Nutrient Sensing | This study suggests that insulin resistance in combination with decreased insulin secretion may be associated with ischemic stroke recurrence or IHD. | 19560684 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In overweight/obese patients with PCOS, lower-abdomen and upper-back SAT showed significant positive correlations with insulin resistance. | 19562283 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | There was no correlation of SAT topography with insulin resistance in lean women with PCOS. | 19562283 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Increased SAT layers on the trunk are associated with insulin resistance, impaired glucose tolerance and an unfavorable lipid profile in women suffering from PCOS. | 19562283 |
| Prostate Cancer Outcomes Study, Truncal obesity, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Compared with PCOS women with normal glucose tolerance, patients with glucose intolerance had significantly increased trunk obesity and decreased leg fat. | 19562283 |
| Atherosclerosis | Deregulated Nutrient Sensing | Hence, we hypothesize that SIRT1 is a key regulator in the pathogenesis of atherosclerosis and that upregulation of SIRT1 in endothelial cells may mimic CR's beneficial effect on vascular health. | 19562740 |
| Atherosclerosis | Deregulated Nutrient Sensing | We infer that SIRT1 may be a novel target for atherosclerosis prevention and treatment. | 19562740 |
| Liver Stiffness | Deregulated Nutrient Sensing | Insulin resistance is a major determinant of liver stiffness in nondiabetic patients with HCV genotype 1 chronic hepatitis. | 19563503 |
| Fibrosis, Liver, Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | Conclusions In nondiabetic patients with genotype 1 CHC, insulin resistance, gammaGT and platelet levels contribute to LSM independently of liver fibrosis. | 19563503 |
| Neoplasms | Deregulated Nutrient Sensing | Activation of AMPK can suppress tumor formation and inhibit cell growth in addition to lowering blood glucose levels. | 19564453 |
| Acute lymphocytic leukemia, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia. | 19564534 |
| Acute lymphocytic leukemia, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To determine the prevalence of insulin resistance and other risk factors for cardiovascular disease (CVD) in young adult survivors of childhood acute lymphoblastic leukemia (ALL). | 19564534 |
| Acute lymphocytic leukemia | Deregulated Nutrient Sensing | ALL survivors had an increased prevalence of insulin resistance in comparison with a cohort of older individuals from the same community. | 19564534 |
| Lipolysis, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8, Diabetes Mellitus | Deregulated Nutrient Sensing | Because GH stimulates lipolysis, an increase in circulating free fatty acid levels, as opposed to a direct effect of high GH levels, could underlie the development of insulin resistance in type 1 diabetes (T1D). | 19567515 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Deregulated Nutrient Sensing | Our aim was to explore the relative contributions of GH and free fatty acids to the development of insulin resistance in patients with T1D. | 19567515 |
| Dyslipidemias, Obesity, Blood Glucose | Deregulated Nutrient Sensing | Erythrocyte acid phosphatase (ACP locus 1), also known as low-molecular-weight protein tyrosine phosphatase, has previously been associated to glycemia, dyslipidemia, and obesity. | 19570551 |
| Obesity | Deregulated Nutrient Sensing | The evidence for pleiotropic control of insulin and central obesity-related traits supports the presence of an insulin resistance syndrome in South Asians with a tendency for central obesity. | 19570552 |
| Obesity | Deregulated Nutrient Sensing | Glucocorticoids play an important role in the pathogenesis of obesity and insulin resistance. | 19571556 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance among Brazilian schoolchildren: association with risk factors for cardiovascular diseases. | 19572942 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Sixty-nine point six percent of the diabetes mellitus (DM) inpatients was accompanied with dyslipidemia and the rate was higher than those in NGT (56.4%) and IGR inpatients (52.5%, P < 0.05, respectively). | 19576085 |
| Dyslipidemias | Deregulated Nutrient Sensing | Only 22.8% of the PDM inpatients underwent treatment of dyslipidaemia and just 3.4% achieved the target suggested by the guideline of ATP-III. | 19576085 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. | 19576324 |
| Inflammation | Deregulated Nutrient Sensing | In conclusion, these results suggest that the previously reported association between poor fitness and low-grade inflammation may be largely attributable to increased visceral AT accumulation and its associated state of insulin resistance, conditions frequently observed in subjects with poor cardiorespiratory fitness. | 19576354 |
| Overweight, Obesity | Deregulated Nutrient Sensing | Multivariate analysis found risk factors associated to insulin resistance for non-diabetic adults with low income and educational level: overweight, obesity, elevated waist-to-hip ratio, C-reactive protein and skin color. | 19578594 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Impact of abdominal fat and insulin resistance on arterial hypertension in non-obese women. | 19578595 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To evaluate the impact of abdominal fat and insulin resistance on arterial hypertension of non-obese women. | 19578595 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Arterial hypertension in non-obese women is associated with insulin resistance, central fat distribution and higher leptin levels. | 19578595 |
| Increased insulin level, Nail-Patella Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | These patients with NPS did not show hyperinsulinemia or dyslipidemia. | 19579756 |
| Dyslipidemias, Breast Carcinoma | Deregulated Nutrient Sensing | This study confirms the association between dyslipidaemia, BMI and increased breast cancer risk. | 19579966 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | IMT increased 79+/-7 mum (mean+/-SEM) in subjects with MetS according to the MetS/European Group for the Study of Insulin Resistance definition and 42+/-2 mum in subjects without MetS (P<0.0001). | 19581494 |
| Cardiac complication, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is common in type 1 diabetes patients and is associated with microvascular complications. | 19584183 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and insulin resistance. | 19584882 |
| Non-alcoholic Fatty Liver Disease, Atherosclerosis | Deregulated Nutrient Sensing | The aims of this study were to examine the risk factors and heritability of NAFLD in 795 Hispanic American and 347 African-American adults participating in the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. | 19584882 |
| Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction. | 19584917 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Coffee drinking has been reported to have beneficial effects on insulin resistance, which has been directly associated with endometrial cancer. | 19585497 |
| Hepatobiliary Disorder, Hepatitis C, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance is observed more in patients with HCV infection compared with control subjects with liver disease, Initial studies suggested that Hepatitis C virus infection may be an additional risk factor for the development of diabetes mellitus. | 19586535 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Laparoscopic surgery improves blood glucose homeostasis and insulin resistance following distal gastrectomy for cancer. | 19587383 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A variation in the cerebroside sulfotransferase gene is linked to exercise-modified insulin resistance and to type 2 diabetes. | 19587831 |
| Hyperinsulinism | Deregulated Nutrient Sensing | Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism. | 19588121 |
| Hyperinsulinism | Deregulated Nutrient Sensing | We hypothesised that the age-related defect in muscle protein anabolism is a true insulin resistance state and can be overridden by supraphysiological hyperinsulinaemia. | 19588121 |
| Hyperinsulinism | Deregulated Nutrient Sensing | We conclude that supraphysiological hyperinsulinaemia is necessary to stimulate muscle protein synthesis and anabolic signalling in healthy older individuals, suggesting the existence of a true age-related insulin resistance of muscle protein metabolism. | 19588121 |
| Inflammation, Glucose Intolerance (disease), Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity leads to increased risk of cardiovascular disease and glucose intolerance, which are phenomena of chronic inflammation. | 19588793 |
| Critical Illness | Deregulated Nutrient Sensing | Critically ill patients requiring intensive care uniformly develop insulin resistance. | 19589139 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Soluble CD40 ligand levels in essential hypertensive men: evidence of a possible role of insulin resistance. | 19590499 |
| Dyslipidemias, Splenomegaly, Kidney Diseases | Deregulated Nutrient Sensing | Splenomegaly with sea-blue histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol acyltransferase deficiency: a clinicopathologic correlation. | 19592052 |
| Lecithin Acyltransferase Deficiency, Dyslipidemias, Splenomegaly, Kidney Diseases | Deregulated Nutrient Sensing | We describe a case with the triad of splenomegaly with sea-blue histiocytes, nephropathy, and dyslipidemia in a patient with LCAT deficiency. | 19592052 |
| Inflammation, Coronary Artery Disease, Endothelial dysfunction | Deregulated Nutrient Sensing | In conclusion, insulin resistance, endothelial dysfunction, and inflammation are important cardiovascular risk factors in coronary artery disease patients; and L-arginine seems to have anti-inflammatory and metabolic advantages in these patients. | 19592054 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. | 19592624 |
| Inflammation, Beta-cell dysfunction | Deregulated Nutrient Sensing | Subclinical inflammation leads to insulin resistance and beta-cell dysfunction. | 19592635 |
| Obesity | Deregulated Nutrient Sensing | [Obesity and insulin resistance among adolescents from Chiapas]. | 19593490 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This novel approach of improving muscle insulin resistance may be a potential alternative treatment for type 2 diabetes mellitus. | 19593542 |
| Hyperglycemia, Glucose Intolerance (disease), Hyperinsulinism, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Skeletal myoblast transplantation for attenuation of hyperglycaemia, hyperinsulinaemia and glucose intolerance in a mouse model of type 2 diabetes mellitus. | 19593542 |
| Non-ST Elevation Myocardial Infarction by ECG Finding, Dyslipidemias | Deregulated Nutrient Sensing | The non-STEMI patients were older, used more medication, had undergone more often coronary interventions, but did not differ with respect to risk factors, except for a higher incidence in dyslipidemia. | 19596303 |
| Inflammation, Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Renal failure is associated with dyslipidemia and inflammation in normal-weight patients. | 19596588 |
| Dyslipidemias, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest that primary prevention strategies for renal disease should focus on individuals with elevated blood pressure, diabetes mellitus, and dyslipidemia. | 19597042 |
| Hypertension, CTCAE, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Coronary heart disease, hypertension, and dyslipidemia are highly prevalent and commonly coexist in people who are middle-aged and older. | 19602720 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Serum HCV RNA levels and HCV genotype do not affect insulin resistance in nondiabetic patients with chronic hepatitis C: a multicentre study. | 19604179 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic hepatitis C (CHC) induces insulin resistance (IR) and subsequently diabetes. | 19604179 |
| Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | Both insulin resistance (type II diabetes) and beta-amyloid (Abeta) oligomers are implicated in Alzheimer's disease (AD). | 19605645 |
| Dyslipidemias, Blood Vessel, Lupus Erythematosus | Deregulated Nutrient Sensing | In systemic lupus erythematosus they were highly associated with inflammatory markers and dyslipidemia, and may ultimately contribute to vascular damage. | 19606253 |
| Takayasu Arteritis, Dyslipidemias, Lupus Erythematosus | Deregulated Nutrient Sensing | The lack of anti-LPL antibodies in Takayasu's disease implies distinct mechanisms underlying dyslipidemia compared to systemic lupus erythematosus. | 19606253 |
| Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | Central obesity and insulin resistance in the cardiometabolic syndrome: pathways to preclinical cardiovascular structure and function. | 19614791 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes and dyslipidaemia were independent predictors of decreased primary patency (p=0.003 and p=0.014, respectively). | 19616976 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The extent of the disease, diabetes and dyslipidaemia are associated with worse outcome. | 19616976 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Factors for most frequent risk were: obesity (56.8%), consumption of alcohol (22.1%) and dyslipidemia (13.4%). | 19617169 |
| Polycystic Ovary Syndrome, Follicular cell of ovary | Deregulated Nutrient Sensing | The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome. | 19617605 |
| Prostate Cancer Outcomes Study, Endocrine System Diseases, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Hyperandrogenaemia and insulin resistance are prominent features of polycystic ovary syndrome (PCOS) and influence the process of folliculogenesis in women with the endocrinopathy. | 19617605 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The relationships between AMH and insulin resistance and androgenaemia in patients with and without PCOS were studied. | 19617605 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | These observations indicate that AMH is similarly related to insulin resistance and androgens in women with and without PCOS. | 19617605 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Factors associated with insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes. | 19618346 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, flavin-hypoxanthine dinucleotide | Deregulated Nutrient Sensing | To investigate the changes of insulin resistance and fasting plasma ghrelin levels in adolescents with obesity and family history of type 2 diabetes mellitus (FHD) and analyze its related factors. | 19618346 |
| Obesity, flavin-hypoxanthine dinucleotide, Diabetes Mellitus | Deregulated Nutrient Sensing | This study showed that the subjects with FHD and obesity who are predisposed to diabetes have insulin resistance in adolescent stage. | 19618346 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients underwent measurements of height, weight and waist circumference and provided data on reported cardiovascular disease (CVD), diabetes, hypertension and dyslipidaemia. | 19619215 |
| Obesity | Deregulated Nutrient Sensing | The association of ghrelin with insulin resistance provides further evidence on the regulation of ghrelin in glucose homeostasis in childhood obesity at the prepubertal age. | 19619916 |
| Dyslipidemias, Data types - Address | Deregulated Nutrient Sensing | Our study shows a higher prevalence of central adiposity, impaired glucose tolerance and dyslipidemia in AD patients. | 19620820 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects. | 19622625 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Previous studies reported independent associations of hematological parameters with risk of incident type 2 diabetes, although limited data are available on associations of these parameters with insulin resistance (IR) and (especially) pancreatic beta-cell dysfunction in large epidemiological studies. | 19622625 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Individuals are predisposed to insulin resistance and its complications, including features of polycystic ovary syndrome. | 19622949 |
| Steatohepatitis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Metabolic testing identified diabetes mellitus, dyslipidemia, and steatohepatitis. | 19622949 |
| Congestive heart failure, Dyslipidemias, Chronic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors for CHF were being on social assistance, diabetes, dyslipidaemia, higher chronic disease score and developing a cardiovascular condition during follow-up. | 19623691 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity was found in 40%, high blood pressure in 39%, dyslipidemia in 37%, diabetes mellitus in 10%, smoking in 7%, and cardiovascular disease in 6% of the patients. | 19627704 |
| Prehypertension, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prehypertension is associated with cardiovascular disease and insulin resistance. | 19628813 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Acetylcholinesterase inhibition and insulin resistance in late onset Alzheimer's disease. | 19631004 |
| Alzheimers Disease", Loading Technique | Deregulated Nutrient Sensing | Insulin resistance (IR) may play a role in most pathogenic processes that promote the development of late onset Alzheimer's disease (LOAD). | 19631004 |
| Hypertension, CTCAE, Kidney Failure, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Women, older mean age, hypertension, dyslipidemia, previous stroke and renal insufficiency were more prevalent in the D group. | 19634498 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased hepatocellular lipids relate to insulin resistance and are typical for individuals with type 2 diabetes mellitus (T2DM). | 19637187 |
| Fatty degeneration | Deregulated Nutrient Sensing | These data suggest that impaired hepatic energy metabolism and insulin resistance could precede the development of steatosis in individuals with T2DM. | 19637187 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity is associated with diabetes mellitus, hypertension, dyslipidemia and increased cardiovascular disease (CVD) risk. | 19638708 |
| Autoimmune Diseases, Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | It has been suggested that metabolic demand and insulin resistance play a role in the development of type 1 diabetes, including the onset of autoimmunity. | 19641897 |
| Autoimmune Diseases | Deregulated Nutrient Sensing | These findings are inconsistent with the notion that insulin resistance is a risk factor for islet autoimmunity. | 19641897 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Participants had an increased likelihood of hypertension (systolic blood pressure), dyslipidemia (elevated triacylglycerol and descending HDL-C) and diabetes mellitus at WHR > or = 0.84. | 19642371 |
| Acute Coronary Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Body mass and atherogenic dyslipidemia as major determinants of blood levels of B-type natriuretic peptides in Arab subjects with acute coronary syndromes. | 19642911 |
| Dyslipidemias, Erectile dysfunction | Deregulated Nutrient Sensing | The independent link with atherogenic dyslipidemia suggests that BNP is important in atherogenesis and may not be just an index of cardiac contractile dysfunction. | 19642911 |
| Inflammation, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Current research has focused upon the potential links between novel markers of vascular risk such as endothelial dysfunction, oxidative stress, inflammation and insulin resistance in the pathogenesis of Type 2 diabetes and its complications. | 19646193 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In chronic kidney disease the contribution of decreased glomerular filtration rate (GFR) versus enhanced inflammation to cause insulin resistance (IR) is controversial. | 19648735 |
| Kidney Failure, Chronic, Arterial Stiffness | Deregulated Nutrient Sensing | Patients with end-stage renal disease are known to have insulin resistance and advanced arterial stiffness. | 19648738 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is a heterogeneous disease resulting from insulin resistance and/or from a beta-cell secretory defect. | 19651806 |
| Fatty Liver | Deregulated Nutrient Sensing | Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. | 19651814 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type. | 19656356 |
| Ventricular Fibrillation | Deregulated Nutrient Sensing | In contrast, EGP and the product of EGP and SSPI during the insulin clamp (an index hepatic insulin resistance) correlated positively with VF/SF ratio, but not with BMI, FM, VF or SF. | 19656356 |
| Obesity | Deregulated Nutrient Sensing | We conclude that, independent of the individual's body type, visceral fat dominant accumulation as opposed to subcutaneous fat accumulation is associated with hepatic insulin resistance, whereas peripheral (muscle) insulin resistance is more closely related to general obesity (i.e. | 19656356 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia in patients with CKD has been recognized as a risk factor for disease progression but the role of triglycerides (TGs) remains controversial. | 19657271 |
| Blood coagulation, Endothelial dysfunction, Atherosclerosis | Deregulated Nutrient Sensing | There was a statistically significant improvement in insulin resistance: M value 2.55 (1.92; 3.15) vs. 3.32 (2.23; 4.49) mg/kg per min (P<0.01), and improvement in atherosclerosis risk factors (blood coagulation and endothelial dysfunction): fibrinogen 3.44 (3.13; 3.86) vs. 3.24 (2.77; 3.38) g/l, factor VII 115 (101; 128) vs. 109 (93; 119)%, factor VIII 230 (148; 260) vs. 188 (126; 225)%, vWF:RiCo 162 (141; 193) vs. 128 (100; 132)%, PAI-1 39 (30; 44) vs. 30 (25; 36) AU/ml, thrombomodulin Ag 4.1 (3.7; 4.4) vs. 3.7 (3.45; 4.05) ng/ml (P<0.01). | 19657609 |
| Blood coagulation, Endothelial dysfunction | Deregulated Nutrient Sensing | Six months of CSII treatment led to decrease in insulin resistance and improvement in parameters of lipid metabolism, blood coagulation and endothelial dysfunction independently of glycemic control and weight. | 19657609 |
| Tumor necrosis | Deregulated Nutrient Sensing | The non-invasive laboratory markers measured were insulin resistance, tumor necrosis factor (TNF-alpha), type IV collagen and hyaluronic acid (HA). | 19659788 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease. | 19661128 |
| Obesity | Deregulated Nutrient Sensing | We examined whether lower testosterone or sex hormone-binding globulin (SHBG) levels in older men are associated with insulin resistance independently of measures of central obesity. | 19661128 |
| Obesity | Deregulated Nutrient Sensing | In older men, lower total testosterone is associated with insulin resistance independently of measures of central obesity. | 19661128 |
| Acquired Immunodeficiency Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | To determine the prevalence and pattern of dyslipidaemia and dysglycaemia amongst Nigerian HIV/AIDS patients on HAART. | 19662738 |
| No metabolic abnormalities, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance (IR) has been proposed to be a key feature of metabolic abnormalities of hypertension and may precede the elevation of BP. | 19666708 |
| Atherosclerosis | Deregulated Nutrient Sensing | Scavenger receptors play crucial roles in the pathogenesis of atherosclerosis, but their role in insulin resistance has not been explored. | 19667111 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Pioglitazone and adiponectin regulate gene expression of SRA and LOX-1, and this may have clinical implications in arresting the untoward sequalae of insulin resistance and diabetes, including accelerated atherosclerosis. | 19667111 |
| Xanthoma, Dyslipidemias | Deregulated Nutrient Sensing | Remission of the eruption after treatment of dyslipidemia confirmed the diagnosis of the eruptive xanthoma and motivated research about the histological similarities and differences between these diseases. | 19668945 |
| Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Prevalence and type of dyslipidaemia in a population at risk for cardiovascular death in Bulgaria. | 19670537 |
| Acquired Immunodeficiency Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence rates of dyslipidemia and insulin resistance are high in Chinese HIV/AIDS patients receiving HAART, especially in the HIV-LD group. | 19671283 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | The rate of hyperinsulinemia and any kind of dyslipidemia were 25.0% and 59.6%. | 19671283 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Defects in the AMPK system might therefore be an important factor in the pathogenesis of type 2 diabetes. | 19671840 |
| Obesity | Deregulated Nutrient Sensing | Multiple regression analyses indicated that skeletal muscle AMPK mRNA and protein expression as well as activity were regulated by sex, age, obesity, and aerobic capacity. | 19671840 |
| Obesity | Deregulated Nutrient Sensing | Our results suggest that skeletal muscle AMPK expression is under minor genetic control but regulated by age and sex and associated with obesity and aerobic capacity. | 19671840 |
| Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Intravenous glucose tolerance tests suggested impaired beta-cell function; no insulin resistance was observed. | 19673927 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias, Hyperlipidemia | Deregulated Nutrient Sensing | The percentages of hypercholesterolaemia, hypertriglyceridaemia, combined dyslipidaemia, and hyperlipidaemia were 1.2, 8.8, 0.4, and 9.7%, respectively. | 19674498 |
| Hyperlipidemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The incidences of hypertriglyceridaemia, combined dyslipidaemia, and hyperlipidaemia of girls were higher than boys. | 19674498 |
| Demographics Domain, Osage language, Diabetes Mellitus, Glucose Intolerance (disease), Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Although obstructive sleep apnoea (OSA) has been linked to insulin resistance and glucose intolerance, it is unclear whether there is an independent association between OSA and diabetes mellitus (DM) and whether all patients with OSA are at risk. | 19679579 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors for AF, including aging, obesity, and diabetes, have been associated with insulin resistance that leads to depressed/defective PI3K signaling. | 19679877 |
| HIV Infections, Alcoholic Intoxication, Chronic, Dyslipidemias, HIV, Bone necrosis, Lipodystrophy | Deregulated Nutrient Sensing | Osteonecrosis (ON) of the hip in human immunodeficiency virus (HIV)-infected patients has been related to corticosteroid use, dyslipidemia, alcoholism, lipodystrophy, antiretroviral drug use, and HIV infection, itself. | 19683365 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We tested the hypothesis that an elevated level of visceral fat accumulation (VFA) correlates with hippocampus volume and insulin resistance in non-dementia patients with type 2 diabetes. | 19683583 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results indicate that the elevated level of VFA in Japanese non-dementia patients with type 2 diabetes is characterized by increased hippocampus volume and insulin resistance, and that the Z-score and HOMA index are independent predictors of VFA. | 19683583 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this study, we sought to identify mutations in the insulin receptor (INSR) gene, which can cause insulin resistance in type II diabetic patients. | 19688022 |
| Hyperlipidemia, IFNG wt Allele | Deregulated Nutrient Sensing | In patients with IFG and hyperlipidaemia, rosuvastatin treatment was associated with a dose-dependent increase in insulin resistance. | 19691613 |
| Inflammation, Fibrosis Assessment, Weight decreased, Fatty degeneration | Deregulated Nutrient Sensing | The combination of weight loss and antioxidant drugs to ameliorate insulin resistance and improve steatosis, inflammation and fibrosis provides the rational for therapeutic trials. | 19691668 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular risk factors such as diabetes, hypertension, dyslipidaemia and smoking were determined during consultation. | 19693020 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, hypertension, dyslipidaemia and smoking were common cardiovascular risk factors among men with ED. | 19693020 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, hypertension, dyslipidaemia and smoking are common cardiovascular risk factors among men with ED. | 19693020 |
| Non-cirrhotic | Deregulated Nutrient Sensing | Insulin resistance predicts rapid virological response in non-diabetic, non-cirrhotic genotype 1 HCV patients treated with peginterferon alpha-2b plus ribavirin. | 19695729 |
| Ventricular Fibrillation | Deregulated Nutrient Sensing | As bioavailable testosterone was associated with VF even after adjusting for insulin resistance, this suggests that it plays an important role in regional fat distribution. | 19696765 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | The subjects with central obesity, compared to the controls, after adjusting for age, race, and gender, had significantly greater diastolic blood pressure, mean arterial pressure, low-density lipoprotein cholesterol level, triglycerides, triglycerides/high-density lipoprotein cholesterol ratio, insulin, homeostasis model assessment of insulin resistance, uric acid, C-reactive protein, and liver function enzymes (alanine aminotransferase and gamma-glutamyl transferase). | 19699351 |
| Dyslipidemias, Hypertension, CTCAE, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | The central obesity group also had a greater prevalence of dyslipidemia, hypertension, insulin resistance, hyperuricemia, and elevated C-reactive protein. | 19699351 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer. | 19700655 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study. | 19703913 |
| Gestational Diabetes, Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Although women with gestational diabetes have an increased risk of cardiovascular disease, it is not known whether mild glucose intolerance during pregnancy is also associated with cardiovascular disease. | 19703913 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Mild glucose intolerance in pregnancy may be associated with an increased risk of cardiovascular disease. | 19703913 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Presence of corneal arcus in middle-aged men may be an indicator for dyslipidemia, and we speculate that the relationship between arcus and coronary heart disease may be dependent of dyslipidemia. | 19707111 |
| Units Of Measure - Siemens | Deregulated Nutrient Sensing | Lower concentrations of hepatic enzymes, in particular, lower circulating ALT levels, in MHO individuals may reflect lower hepatic insulin resistance and lower liver fat content; and this could be involved, at least in part, in the protective profile of MHO individuals. | 19709695 |
| Obesity | Deregulated Nutrient Sensing | Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. | 19712485 |
| Obesity | Deregulated Nutrient Sensing | The interrelationships between desaturase indices derived from different serum lipid fractions and adipose tissue are unclear, as well as their associations with obesity and insulin resistance. | 19712485 |
| Obesity | Deregulated Nutrient Sensing | SCD-1 activity index in adipose tissue is best reflected by 16:1/16:0-ratio in serum FFA, but associations with obesity and insulin resistance differ between these pools. | 19712485 |
| Obesity | Deregulated Nutrient Sensing | D5D in PL was inversely related to obesity and insulin resistance, whereas D6D index showed positive associations. | 19712485 |
| Heart failure | Deregulated Nutrient Sensing | Aldosterone status associated with insulin resistance in patients with heart failure--data from the ALOFT study. | 19713201 |
| Heart failure, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is a risk factor in heart failure and cardiovascular disease. | 19713201 |
| Heart failure | Deregulated Nutrient Sensing | This study demonstrates a novel direct relation between aldosterone status and insulin resistance in heart failure. | 19713201 |
| Dyslipidemias, Family history, Atherosclerosis | Deregulated Nutrient Sensing | However, based on his advanced atherosclerosis, we cannot exclude the possibility that our patient may be accompanying dyslipidemia due to causes in addition to heterozygous FH. | 19713675 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Because omental adipose tissue has been strongly associated with the development of insulin resistance, type 2 diabetes and cardiovascular disease, we searched for proteins differentially expressed in these two fat depots using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) and mass spectrometry (MS). | 19714809 |
| Communicable Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Side effects were dyslipidemia in 8 and infection in 2. | 19715864 |
| deficiency aspects | Deregulated Nutrient Sensing | It is characterized by insulin resistance in peripheral tissues and a relative deficiency in the pancreatic beta-cell functions. | 19716569 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Diverse single nucleotide polymorphisms (SNPs) of the IRS1 gene have been associated with insulin resistance and T2D risk. | 19716569 |
| Microalbuminuria, Microvascular Angina, Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance and microalbuminuria are associated with microvascular disease in patients with cirrhosis. | 19718631 |
| Fatty Liver Disease, Williams Syndrome, Obesity | Deregulated Nutrient Sensing | Central obesity and insulin resistance are common symptoms of both NASH and WS. | 19720629 |
| Hyperlipidemia, Liver Dysfunction | Deregulated Nutrient Sensing | Liver dysfunction, hyperlipidaemia, insulin resistance and regional increase of intra-abdominal fat even though the body mass indices were all normal or low, were observed. | 19720629 |
| Weight decreased | Deregulated Nutrient Sensing | Low-fat versus low-carbohydrate weight reduction diets: effects on weight loss, insulin resistance, and cardiovascular risk: a randomized control trial. | 19720791 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low-fat hypocaloric diets reduce insulin resistance and prevent type 2 diabetes in those at risk. | 19720791 |
| Weight decreased | Deregulated Nutrient Sensing | Low-carbohydrate, high-fat diets are advocated as an alternative, but reciprocal increases in dietary fat may have detrimental effects on insulin resistance and offset the benefits of weight reduction. | 19720791 |
| Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | VRF sought were high blood pressure, dyslipidemia, diabetes mellitus, tobacco smoking, and atherosclerotic disease. | 19720973 |
| Squamous cell carcinoma, Hepatitis C, SERPINB3 wt Allele | Deregulated Nutrient Sensing | We investigated the association among oral squamous cell carcinoma (OSCC), multiple primary cancers (MPCs), insulin resistance and HCV infection. | 19721396 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Histological evaluation of AMPK signalling in primary breast cancer. | 19723334 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Malfunction of the AMPK pathway may allow cancer cells to undergo uncontrolled proliferation irrespective of their molecular energy levels. | 19723334 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The aim of this study was to examine the state of AMPK phosphorylation histologically in primary breast cancer in relation to clinical and pathological parameters. | 19723334 |
| 5-Trimethoxyamphetamine, Malignant neoplasm of breast | Deregulated Nutrient Sensing | Immunohistochemistry was performed using antibodies to phospho-AMPK (pAMPK), phospho-Acetyl Co-A Carboxylase (pACC) an established target for AMPK, HER2, ERalpha, and Ki67 on Tissue Micro-Array (TMA) slides of two cohorts of 117 and 237 primary breast cancers. | 19723334 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | This study extends in vitro evidence through immunohistochemistry to confirm that AMPK is dysfunctional in primary breast cancer. | 19723334 |
| Neoplasm Metastasis, Breast Carcinoma | Deregulated Nutrient Sensing | Reduced signalling via the AMPK pathway, and the inverse relationship with histological grade and axillary node metastasis, suggests that AMPK re-activation could have therapeutic potential in breast cancer. | 19723334 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting of inadequate beta-cell compensation. | 19727413 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Resistin is a cytokine derived from adipose tissue and is implicated in obesity-related insulin resistance and type 2 diabetes mellitus. | 19727657 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In addition, plasma resistin level was associated with dyslipidaemia, serum insulin concentration and obesity. | 19727657 |
| Adipose tissue loss, Dyslipidemias, Diabetes Mellitus, Lipodystrophy, Disease | Deregulated Nutrient Sensing | Lipodystrophy is a rare disorder characterised by loss of adipose tissue, hypoleptinaemia, severe insulin resistance, diabetes and dyslipidaemia. | 19727665 |
| Lipodystrophy, Dyslipidemias | Deregulated Nutrient Sensing | Leptin replacement in lipodystrophy patients leads to significant and sustained improvements in glycaemic control and dyslipidaemia. | 19727665 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. | 19728183 |
| Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | TCM can ameliorate insulin resistance in type 2 diabetes and it is safe and effective in newly diagnosed diabetic patients. | 19728183 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Usefulness of statin-ezetimibe combination to reduce the care gap in dyslipidemia management in patients with a high risk of atherosclerotic disease. | 19733714 |
| Primary malignant neoplasm, Dyslipidemias | Deregulated Nutrient Sensing | The PCI group was significantly associated with older age, dyslipidemia, history of cancer, high Euroscore, elevated creatininemia, single-vessel disease, fewer chronic occlusions of the left anterior descending artery, and more LMCA stenosis >or=70%. | 19735473 |
| Hyperleucinemia, Hyperglycemia | Deregulated Nutrient Sensing | BRO group presented hyperglycaemia (+16%, P < 0.05), lower muscle glycogen (51%, P < 0.05), higher cholesterol (+30%, P < 0.05), higher low-density lipoprotein (LDL-c) (+1.5 times, P < 0.05), higher triglycerides (+49%, P < 0.05), lower HDL-c (28%, P < 0.05), hyperleptinaemia (+2.9 times, P < 0.05), hypoadiponectinaemia (16%, P < 0.05) and hypoprolactinaemia (54%, P < 0.05) as well as higher insulin resistance index (+24%, P < 0.05). | 19736303 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes. | 19738363 |
| Obesity | Deregulated Nutrient Sensing | SIRT1 genetic variation is related to BMI and risk of obesity. | 19741164 |
| Obesity | Deregulated Nutrient Sensing | The availability of SIRT1 stimulators makes these findings relevant in light of the growing obesity epidemic. | 19741164 |
| Sleep-Disordered Breathing, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Sleep disordered breathing (SDB) has been associated with cardiovascular disease, hypertension, and insulin resistance. | 19743760 |
| Sleep-Disordered Breathing | Deregulated Nutrient Sensing | SDB was significantly correlated with insulin resistance (Spearman r correlation between AHI and HOMA=0.30, P<0.0001). | 19743760 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance is an independent additional risk factor for hypertension. | 19748246 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | The elevation of high-sensitivity C-reactive protein (hs-CRP) is a strong risk factor for cardio-vascular disease (CVD) and is associated with insulin resistance. | 19749491 |
| Infection caused by Helicobacter pylori | Deregulated Nutrient Sensing | Helicobacter pylori infection significantly increases insulin resistance in the asymptomatic Japanese population. | 19751440 |
| Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is the pathophysiologic background of the clinical features of atherosclerosis and cardiovascular diseases. | 19751440 |
| Infection caused by Helicobacter pylori | Deregulated Nutrient Sensing | Helicobacter pylori infection significantly and independently contributed to promoting insulin resistance in a large asymptomatic population. | 19751440 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance and risk of incident hypertension among men. | 19751460 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance is independently associated with incident hypertension among younger men. | 19751460 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Diets with a high postprandial glycaemic response may contribute to the long-term development of insulin resistance and diabetes; however, earlier epidemiological studies are conflicting on whether glycaemic index (GI) or glycaemic load (GL) are dietary factors associated with the progression. | 19756025 |
| Dyslipidemias, Kidney Diseases, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidaemia does not only accelerate atherosclerosis in these patients but also progresses the renal disease. | 19764669 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | All factors that may lead to dyslipidaemia were excluded in all subjects except hypertension. | 19764669 |
| Dyslipidemias | Deregulated Nutrient Sensing | The pattern of lipid profile did not change with severity of disease and dyslipidaemia in patients were more in triglycerides, 68.3% and HDL, 63.5% than in TC, 22.2% and LDL, 17.5%. | 19764669 |
| Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is common in pre-dialysis chronic kidney disease patients. | 19764669 |
| Damage, Dyslipidemias | Deregulated Nutrient Sensing | It is pertinent to investigate and treat dyslipidaemia early in the course of the disease as it may prevent further progression of the renal damage. | 19764669 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients. | 19765773 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We aimed to determine whether insulin resistance or various biomarkers of cardiovascular risk have a role in the link between cystatin C and CVD in type 2 diabetes mellitus patients. | 19765773 |
| Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | RBP4 has been associated with insulin resistance and hypertriglyceridemia in obesity, the metabolic syndrome and type 2 diabetes. | 19765959 |
| Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Adjusting for CHD risk factors (smoking, diabetes, blood pressure, obesity and dyslipidemia) attenuated RRs. | 19766217 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4), a molecule secreted from adipocytes and hepatocytes, may contribute to insulin resistance and is a potential predictor for type 2 diabetes mellitus. | 19766271 |
| Heart Diseases, Inflammation | Deregulated Nutrient Sensing | This association does not appear to be mediated by co-morbid conditions, cardiac disease severity, insulin resistance, inflammation, neurohormones, or adipokines. | 19766751 |
| Fatty Liver | Deregulated Nutrient Sensing | Gender-specific prevalences of fatty liver in obese children and adolescents: roles of body fat distribution, sex steroids, and insulin resistance. | 19773396 |
| Fatty degeneration | Deregulated Nutrient Sensing | Severity of steatosis was associated with increased visceral fat mass, insulin resistance, lower adiponectin levels, and higher blood pressure. | 19773396 |
| Fatty degeneration | Deregulated Nutrient Sensing | Risk for steatosis hepatis with concomitantly elevated ALT was associated only with "insulin resistance and visceral fat" in girls and with all three factors in boys. | 19773396 |
| Non-alcoholic Fatty Liver Disease, Obesity, Visceral | Deregulated Nutrient Sensing | Our results suggest significant associations of NAFLD with markers of visceral obesity and insulin resistance in both genders and gender-specific associations with parameters of body fat distribution and sex steroids. | 19773396 |
| Mitochondrial cardiomyopathy, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Physical and laboratory findings, including glucose intolerance and elevated serum lactate, suggested mitochondrial cardiomyopathy. | 19777318 |
| Dyslipidemias | Deregulated Nutrient Sensing | They frequently had dyslipidaemia and both PPM groups received a biological valve more often than patients without PPM (94.1 and 77.1 vs. 19.1%, p<0.0001). | 19784883 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Comparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia. | 19785568 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | The primary objective of this study was to demonstrate equivalence of pitavastatin compared with simvastatin in the reduction of low-density lipoprotein cholesterol (LDL-C) levels in patients with primary hypercholesterolaemia or combined dyslipidaemia. | 19785568 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | A prospective, randomised, active-controlled double-blind, double-dummy, 12-week therapy trial was conducted in 857 patients with either primary hypercholesterolaemia or combined dyslipidaemia. | 19785568 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | As compared with simvastatin, an established first-line lipid-lowering agent, pitavastatin is an efficacious treatment choice in patients with primary hypercholesterolaemia or combined dyslipidaemia. | 19785568 |
| Dyslipidemias, Overweight, diabetic | Deregulated Nutrient Sensing | The patients (4 males and 3 females, age 63 +/- 13 years) were either overweight (4) or obese (3); 57% were diabetic and 28.5% had dyslipidemia. | 19787150 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. | 19789205 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Patients newly treated with antihypertensives and with various levels of coronary heart disease (CHD) risk (including dyslipidemia, established CHD, type 2 diabetes mellitus, and no CHD but three or more cardiovascular risk factors) were included in the study. | 19791839 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The cumulative probability of being prescribed a statin increased with increasing numbers of CHD risk factors, irrespective of dyslipidemia status. | 19791839 |
| Hypertensive (finding), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is associated with increased renal resistive index independent of other factors in newly diagnosed type 2 diabetes mellitus and hypertensive patients. | 19793596 |
| Inflammation, Endotoxemia | Deregulated Nutrient Sensing | Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. | 19794059 |
| Diabetes Mellitus, Ventricular Dysfunction, Left, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Whole body and myocardial insulin resistance are features of non-insulin-dependent diabetes mellitus (NIDDM) and left-ventricular dysfunction (LVD). | 19797329 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | Our data show that the mechanisms of myocardial insulin resistance are different between NIDDM and LVD. | 19797329 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans. | 19798069 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Several research studies in different populations indicate that inflammation may be the link between obesity and insulin resistance (IR). | 19798069 |
| Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | Significant predictors of plaque were male gender and age and, among women, dyslipidemia. | 19801304 |
| ARCN1 gene, Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Comorbidities include: COPD 55.4%, coronary artery disease 60.9%, diabetes 44.6%, dyslipidemia 66.3% and dialysis 9.8%. | 19803257 |
| Carotid Atherosclerosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | High fat stores in ectopic compartments in men with newly diagnosed type 2 diabetes: an anthropometric determinant of carotid atherosclerosis and insulin resistance. | 19806159 |
| Low Density Array | Deregulated Nutrient Sensing | On the basis of multiple regression analyses, mid-thigh low-density muscle area and muscle attenuation were independently associated with the C-IMT, and the mid-thigh normal-density muscle area and muscle attenuation were independent factors of insulin resistance. | 19806159 |
| Carotid Atherosclerosis | Deregulated Nutrient Sensing | Furthermore, altered lipid partitioning within muscle was independently associated with carotid atherosclerosis and insulin resistance. | 19806159 |
| Obesity | Deregulated Nutrient Sensing | The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. | 19808853 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance, beta-cell dysfunction, and conversion to type 2 diabetes in a multiethnic population: the Insulin Resistance Atherosclerosis Study. | 19808919 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and beta-cell function are major predictors of type 2 diabetes, but studies using direct methods of insulin resistance and secretion are few and relatively small. | 19808919 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevention of type 2 diabetes should focus on interventions that improve both insulin resistance and insulin secretion. | 19808919 |
| Hyperglycemia, Obesity, Abdominal | Deregulated Nutrient Sensing | Specific relation between abdominal obesity and early-phase hyperglycemia is modulated by hepatic insulin resistance in healthy older women. | 19808930 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. | 19808930 |
| Hyperglycemia, Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity relates specifically to early-phase hyperglycemia via hepatic insulin resistance, even in healthy older women. | 19808930 |
| Chronic liver disease, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is strongly associated with insulin resistance. | 19813185 |
| Myotonic Dystrophy, IGHD1-7 gene, Muscular Dystrophy | Deregulated Nutrient Sensing | Myotonic dystrophy (DM1) is the most common form of adult-onset muscular dystrophy, and there is a high frequency of insulin resistance due to insulin receptor mRNA splicing defects in muscle tissue. | 19813185 |
| Non-alcoholic Fatty Liver Disease, IGHD1-7 gene | Deregulated Nutrient Sensing | Thirty-six patients with DM1 were prospectively assessed for the presence of NAFLD and insulin resistance. | 19813185 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These findings support the role of peripheral insulin resistance in the pathogenesis of NAFLD. | 19813185 |
| diabetic | Deregulated Nutrient Sensing | Comparisons of diabetic potential, glucose related metabolic levels, and insulin resistance between olanzapine and risperidone have produced variable results in cross-sectional and epidemiologic studies. | 19814947 |
| methionine | Deregulated Nutrient Sensing | Insulin resistance was significantly attenuated in both groups, but to a lesser degree in the MET group (P = .045). | 19815243 |
| Asthma, Dyslipidemias | Deregulated Nutrient Sensing | asthma and dyslipidaemia) than those reported by surveys, with certain age- and sex-related variations. | 19815673 |
| Proteinuria, Steatohepatitis, Left ventricular mass | Deregulated Nutrient Sensing | Other insulin resistance-related features, including hepatic steatosis, increased left ventricular mass, and proteinuria, were also associated with IOP (P<0.0001, 0.002, and 0.01, respectively). | 19816514 |
| Hypoadiponectinemia, Coronary Artery Disease | Deregulated Nutrient Sensing | Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients. | 19818293 |
| Obesity | Deregulated Nutrient Sensing | Importantly, elevated levels of ADAM17 expression have been linked to obesity and insulin resistance. | 19819120 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, a risk factor for cardiovascular disease (CVD), is more prevalent in middle-aged women than in men of the same age in Korea. | 19819450 |
| Obesity | Deregulated Nutrient Sensing | At the time of follow-up, AMS children exhibited 3-fold lower prevalence of severe obesity (11 vs. 35%, P = 0.004), greater insulin sensitivity (homeostasis model assessment of insulin resistance index 3.4 +/- 0.3 vs. 4.8 +/- 0.5, P = 0.02), improved lipid profile (cholesterol/high-density lipoprotein cholesterol 2.96 +/- 0.11 vs 3.40 +/- 0.18, P = 0.03; high-density lipoprotein cholesterol 1.50 +/- 0.05 vs. 1.35 +/- 0.05 mmol/liter, P = 0.04), lower C-reactive protein (0.88 +/- 0.17 vs. 2.00 +/- 0.34 microg/ml, P = 0.004), and leptin (11.5 +/- 1.5 vs.19.7 +/- 2.5 ng/ml, P = 0.005) and increased ghrelin (1.28 +/- 0.06 vs.1.03 +/- 0.06 ng/ml, P = 0.005) than BMS offspring (AMS vs. BMS, respectively, for all). | 19820018 |
| Obesity, Abdominal, diabetic | Deregulated Nutrient Sensing | There was an age-associated increase in the prevalence of abdominal obesity and insulin resistance in elderly diabetic Japanese subjects, with a clear relationship between waist circumference and insulin resistance. | 19828932 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Furthermore, abdominal obesity was strongly associated with dyslipidaemia and hypertension. | 19832855 |
| square decimeter, Endothelial dysfunction, MS gene, Obesity | Deregulated Nutrient Sensing | Insulin resistance (IR), present in patients with obesity, MS, and DM2, causes disturbances in the signaling pathways required for nitric oxide production, with subsequent endothelial dysfunction. | 19834133 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Our findings indicate that the control of hypertension and dyslipidemia among adult diabetics in the beginning of the decade was poor. | 19834341 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Age, diabetes family history, obesity, dyslipidemia and hypertension were all associated with the presence of diabetes in this study population. | 19836096 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Epidemiological studies have established an association between dyslipidemias and atherosclerosis. | 19838489 |
| Carcinogenesis, Metabolic Diseases, Pancreatic carcinoma | Deregulated Nutrient Sensing | Although mounting evidence suggests that insulin resistance is involved in pancreatic carcinogenesis, few epidemiologic studies have comprehensively investigated the role of lifestyle factors influencing this metabolic disorder in the etiology of pancreatic cancer. | 19838917 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Our study lends support to the hypothesis that dietary and other lifestyle factors influencing insulin resistance modulate pancreatic cancer risk. | 19838917 |
| Chlamydia, Dyslipidemias, Atherosclerotic lesion | Deregulated Nutrient Sensing | Our results imply the synergic contribution of Chlamydia pneumoniae DNA and known dyslipidaemia to the development of atherosclerotic lesions in patients undergoing CABG. | 19838954 |
| insulinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, we hypothesised that characterisation of the islets in these mouse models at an early age should provide a unique opportunity to: (1) identify mechanisms involved in sensing insulin resistance at the level of the beta cells, (2) identify molecular effectors that contribute to increasing beta-cell mass and function, and (3) distinguish primary events from secondary events that are more likely to be present at more advanced stages of diabetes. | 19841237 |
| Dyslipidemias, Malignant Neoplasms, Diabetes Mellitus | Deregulated Nutrient Sensing | De novo diabetes (P < 0.07) or dyslipidemia (P < 0.01) as well as newly diagnosed malignancies (P < 0.059) were however more frequently observed in the Steroid maintenance group. | 19843296 |
| DIAPH2 gene, Ovarian Failure, Premature | Deregulated Nutrient Sensing | In mutant mice lacking the Tsc1 gene in oocytes, the entire pool of primordial follicles is activated prematurely due to elevated mTORC1 activity in the oocyte, ending up with follicular depletion in early adulthood and causing premature ovarian failure (POF). | 19843540 |
| Tumor necrosis, Obesity | Deregulated Nutrient Sensing | Tumor necrosis factor alpha (TNFalpha) is a proinflammatory adipokine hypothesized to link obesity with insulin resistance. | 19846171 |
| Obesity | Deregulated Nutrient Sensing | We tested the hypothesis that the association of measures of TNFalpha activity with insulin resistance is independent of obesity and adipose tissue biomarkers. | 19846171 |
| Arterial Stiffness, Prediabetes syndrome, Uremia | Deregulated Nutrient Sensing | In conclusion, a high prevalence of pre-diabetes, impaired insulin resistance, increased arterial stiffness of aorta as well as impaired augmentation index and vasodilatation was demonstrated in uraemic patients prior to kidney transplantation. | 19846393 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Early postmenopausal women with higher testosterone (T) levels have increased insulin resistance (IR) and cardiovascular risk factors, but whether this translates into increased cardiovascular disease later in life is unknown. | 19846742 |
| Hypertension, CTCAE, Stasis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To evaluate the effect of treatment for tonifying qi, nourishing yin, activating blood circulation and removing stasis on insulin resistance (IR) in patients of type 2 diabetes mellitus (T2DM) complicated with hypertension. | 19848209 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | [Fatty liver disease, insulin resistance and adiponectin in an obese pediatric population]. | 19850541 |
| Kidney Neoplasm | Deregulated Nutrient Sensing | Finally, BHD inactivation led to both mTORC1 and mTORC2 activation in kidney tumors from BHD(d/+) mice and human BHD patients. | 19850877 |
| FLCN protein, human, Renal carcinoma, Kidney Neoplasm | Deregulated Nutrient Sensing | These data support a role for PI3K-AKT pathway activation in kidney tumor formation caused by loss of BHD and suggest that inhibitors of both mTORC1 and mTORC2 may be effective as potential therapeutic agents for BHD-associated kidney cancer. | 19850877 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Fatty acid (FA) synthesis enzymes (FA synthase (FASN) and acetyl-CoA carboxylase (ACC)) are related to metabolic alterations such as obesity, insulin resistance, or dyslipidemia. | 19851294 |
| Hyperglycemia, Hyperparathyroidism, Kidney Failure | Deregulated Nutrient Sensing | Renal insufficiency predisposes to insulin resistance, hyperparathyroidism and derangements in calcium phosphate and nitrogenous compound balance, leading to pre-transplant hyperglycaemia. | 19854851 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women. | 19855365 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Acceptable baked products can be prepared with added fenugreek, which will reduce insulin resistance and treat type 2 diabetes. | 19857068 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These results suggest that increased age, glucose intolerance, and irregular hours independently affect the intracellular clock in humans. | 19861640 |
| deficiency aspects, Chronic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Type-2 diabetes mellitus (T2DM) is a chronic disorder characterized by a varying range of predominant insulin resistance with relative insulin deficiency, to predominant insulin secretory defect with or without insulin resistance. | 19861867 |
| Dyslipidemias, Cystic Fibrosis | Deregulated Nutrient Sensing | Prevalence of dyslipidemia in adults with cystic fibrosis. | 19875344 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia occurs in CF patients however no differences in lipid profiles were seen between those with diabetes and those without. | 19875344 |
| Dyslipidemias | Deregulated Nutrient Sensing | As survival in CF increases, the prevalence of dyslipidemia may increase resulting in clinically important complications. | 19875344 |
| diabetic | Deregulated Nutrient Sensing | Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats. | 19876588 |
| Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | To study the effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats, we first induced a model of type 2 diabetes in rats with a low-dose of streptozotocin. | 19876588 |
| diabetic | Deregulated Nutrient Sensing | As a result, the apoptosis ratio of islet beta cells in diabetic rats was dramatically increased compared to the control group, and mRNA and protein expression of SIRT1 in islet beta cells were much lower than those of the control group. | 19876588 |
| diabetic | Deregulated Nutrient Sensing | These data show that caloric restriction notably improves the sensitivity to insulin and significantly increases mRNA and protein expression of SIRT1 while decreasing the apoptosis ratio of islet beta cells in diabetic rats. | 19876588 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Therefore, SIRT1 may play an important role in the apoptosis of islet beta cells of type 2 diabetes. | 19876588 |
| Dyslipidemias, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of dyslipidemia, hypertension, smoking, sedentariness, postmenopausal women, coronary artery disease (CAD) and familial history of CAD were determined. | 19876761 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (P for trend 0.002) and non-obese persons (P for trend 0.001) independent of insulin resistance. | 19878507 |
| diabetic | Deregulated Nutrient Sensing | In a cohort of 169 type 2 diabetic subjects, plasma levels of APOH, antibodies anti-APOH, lipoprotein subfractions, oxidation, inflammatory and insulin resistance markers and the Trp316Ser and Val247Leu variations in the APOH gene were analyzed. | 19878946 |
| Obesity | Deregulated Nutrient Sensing | Accumulation of stressful life events was associated with insulin resistance, obesity, and triglycerides. | 19880581 |
| Acromegaly | Deregulated Nutrient Sensing | Finally, circulating OCN was the main determinant of insulin resistance and beta-cell function in acromegaly and in vitro, a blunted insulin response was observed in the presence of OCN and GH/IGF-I. | 19880791 |
| Cardiac complication, Heat-Shock Response | Deregulated Nutrient Sensing | Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study. | 19882236 |
| Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus | Deregulated Nutrient Sensing | Oxidative stress has been implicated in the pathogenesis of cardiovascular disease (CVD), diabetes and insulin resistance. | 19882236 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Dyslipidaemia and its management in diabetic patients in an academic centre in Iran. | 19885805 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Dyslipidaemia is accompanied with increased cardiovascular events in diabetic patients. | 19885805 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Although recently we have made improvements in the control of dyslipidaemia in diabetic patients, we have not reached our goals. | 19885805 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | In conclusion, we should revise our point of view to begin and intensify treatment of dyslipidaemia in diabetic patients, to achieve the goal of treatment and prevent cardiovascular events optimally. | 19885805 |
| Weight Gain, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Antipsychotic medications are associated with significant weight gain, type 2 diabetes mellitus, dyslipidemia, and increased cardiovascular risk. | 19888560 |
| Colorectal Neoplasms | Deregulated Nutrient Sensing | Association between adiponectin, resistin, insulin resistance, and colorectal tumors. | 19888587 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance. | 19888587 |
| Hypertensive (finding), Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Participants were hypertensive patients taking ARBs for more than 8 weeks, and having dyslipidaemia, obesity or abnormal glucose metabolism. | 19888787 |
| Proteinuria, Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Intensive treatment was a stepwise implementation of behavior modification, pharmacological therapy targeting hyperglycaemia, hypertension, dyslipidaemia, and proteinuria. | 19889469 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Physical activity was associated with a lower progression to diabetes in the total study population and in individuals with i-IGT, a condition primarily characterised by muscle insulin resistance. | 19898830 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Physical activity did not predict progression to diabetes in individuals with i-IFG, a condition primarily characterised by hepatic insulin resistance. | 19898830 |
| diabetic | Deregulated Nutrient Sensing | Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors. | 19900156 |
| diabetic, Atherosclerosis | Deregulated Nutrient Sensing | M% and leg M% in diabetic patients were negatively correlated with the log-transformed triglyceride/high-density lipoprotein cholesterol (HDL-C) ratio, a marker of insulin resistance and atherosclerosis risk. | 19900156 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The highest risk was conferred by having the combination of risk factors of diabetes, hypertension, and dyslipidemia, with or without weight risk. | 19900158 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The combination of risk factors conferring the highest risk was diabetes, hypertension, and dyslipidemia. | 19900158 |
| Hyperparathyroidism, Primary | Deregulated Nutrient Sensing | Insulin resistance is not coupled with defective insulin secretion in primary hyperparathyroidism. | 19900227 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Success rate was especially low among patients with IS compared with CAD: hypertension (23.8% v 27.2%; P = .028); dyslipidemia (13.6% v 20.3%; P < .001); and abdominal obesity (49.1% v 54.6%; P = .002). | 19900649 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | The decreased endothelial VEGF expression and MVD found in patients with T2DM may be caused by insulin resistance and endothelial dysfunction, which are often present in patients with T2DM. | 19905947 |
| Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype. | 19905981 |
| Fatty degeneration, Hepatitis | Deregulated Nutrient Sensing | Modifications of oxidative stress are reported in hepatitis C. The relationship between insulin resistance (IR), steatosis and oxidative stress is not established. | 19905981 |
| Mental disorders | Deregulated Nutrient Sensing | We studied 24 middle-aged and elderly patients with T2DM who were free of obvious vascular pathology or a psychiatric disorder, and 17 age- and education-matched healthy individuals with no evidence of insulin resistance. | 19906514 |
| AHSG protein, human, Vascular calcification | Deregulated Nutrient Sensing | Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. | 19910501 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The development of Type 2 diabetes mellitus (T2DM) has been recognized to be associated with a combination of pancreatic beta-cell dysfunction and insulin resistance. | 19915388 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Family history of diabetes, exercise, insulin resistance, and leptin and ghrelin levels did not differ by parity group. | 19918009 |
| Dyslipidemias, Lack of awareness finding | Deregulated Nutrient Sensing | The frequency of unawareness about these risk factors was respectively 8.4%, 17.5% and 33.1%.. Family history of CVD was reported by 41% while only 67% reported having any information about DM or dyslipidemia. | 19918665 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | There was a significant association between obesity and dyslipidemia (p=0.04). | 19918665 |
| Dyslipidemias, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Obesity and familial dyslipidemia in children are associated with accelerated atherosclerosis by pathological examination. | 19920030 |
| Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Metabolic factors such as obesity, hypertension, dyslipidemia and hyperglycemia have consistently been associated with increased risk of cardiovascular disease. | 19921129 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia increased from the 1970s to the 1980s but declined in the succeeding decade. | 19921129 |
| Impaired cognition | Deregulated Nutrient Sensing | Recent studies have revealed the associations between insulin resistance (IR) and geriatric conditions such as frailty and cognitive impairment. | 19922671 |
| Hypertension, CTCAE, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | In Korea, the treatment of hypertension and dyslipidemia constitutes an important strategy for the prevention of cardiovascular disease (CVD). | 19922890 |
| Atherosclerosis | Deregulated Nutrient Sensing | Hyperinsulinism was the most important factor associated to the occurrence of new cardiovascular events in Colombian patients with AMI, which emphasizes the pivotal role of insulin resistance in the physiopathologic mechanisms of atherosclerosis, especially in undeveloped countries. | 19923024 |
| Glucose Intolerance (disease), Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | The percentages of subjects with high blood pressure, glucose intolerance, dyslipidemia and hyperuricemia were 57.3, 12.7, 29.4 and 21.3%, respectively. | 19923679 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Chronic Obstructive Airway Disease, Hypertrophy, Obesity | Deregulated Nutrient Sensing | There were no significant sex differences in prevalence of obesity, dyslipidemia, history of chronic obstructive pulmonary disease/asthma, left ventricular (LV) hypertrophy, or history of myocardial infarction. | 19926005 |
| Dyslipidemias | Deregulated Nutrient Sensing | Treatment with rimonabant may improve adipokine levels in overweight/obese patients with dyslipidemia. | 19926622 |
| Sleep-Disordered Breathing | Deregulated Nutrient Sensing | All these changes point to an inflammatory/insulin resistance state, suggesting that SDB in obese children share many similarities with SDB in obese adults. | 19926716 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are highly prevalent in the elderly. | 19927131 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | These results document the importance of combined hypertension and dyslipidemia. | 19927131 |
| Renal Insufficiency, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Laboratory examination showed mild renal dysfunction and mild glucose intolerance. | 19928550 |
| Neoplasms | Deregulated Nutrient Sensing | Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. | 19928762 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. | 19928762 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. | 19928762 |
| Neoplasms | Deregulated Nutrient Sensing | These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. | 19928762 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases. | 19928762 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. | 19928762 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | The elevation of visfatin observed in children and adolescents with MetS was proportionate to number of components of MetS but was not associated with insulin resistance. | 19929281 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Irbesartan has no short-term effect on insulin resistance in hypertensive patients with additional cardiometabolic risk factors (i-RESPOND). | 19929980 |
| White matter lesions, diabetic | Deregulated Nutrient Sensing | Association between plasma high-sensitivity C-reactive protein and insulin resistance and white matter lesions in Japanese type 2 diabetic patients. | 19931932 |
| diabetic | Deregulated Nutrient Sensing | This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HSCRP and insulin resistance in type 2 diabetic patients not receiving insulin treatment. | 19931932 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results of this preliminary study indicate that the presence of WML was associated with the high HSCRP and insulin resistance in these Japanese patients with type 2 diabetes mellitus; larger cohort studies are warranted to confirm these findings. | 19931932 |
| Dyslipidemias, ciliary vesicle, Hypertension, CTCAE | Deregulated Nutrient Sensing | Subjects with NWO also had higher prevalence of dyslipidaemia, hypertension (men), and CV disease (women). | 19933515 |
| Dyslipidemias, Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | diabetes alone increased the risk of atherosclerosis slightly in one affected system (OR 2.28, 95% CI 1.9-2.7) while combination of diabetes, smoking and dyslipidemia enhanced this risk (OR 7.4, 95% CI 2.5-22.4). | 19935590 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a well-established risk factor for cardiovascular diseases in the general population. | 19935998 |
| Hyperglycemia, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both. | 19936237 |
| Dyslipidemias, Overweight, Antihypertensive Agents, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of smoking was lower among hypertensives (adjusted prevalence ratio [APR] = 0.75; 95% CI: 0.64;0.89), whereas prevalence of overweight (APR = 1.37; 95% CI: 1.25;1.49), dyslipidemia (APR = 1.36; 95% CI: 1.26;1.36), and diabetes (APR = 1.37; 95% CI: 1.27;1.37) was higher. | 19936495 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | The presence of diabetes, systemic arterial hypertension and dyslipidemias, as well as the subject perceiving his/her health as regular or poor, were also reported by the interviewees with overweight or obesity. | 19936502 |
| Gastroesophageal reflux disease, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Incidence and severity of hypertension, dyslipidemia, and GERD was comparable in both groups while diabetes was less common but more severe in the DS group (24.2% vs. 35.5%, Ali-Wolfe 3.27 vs. 2.94, p<0.05). | 19937190 |
| Dyslipidemias, Weight decreased, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | In comparison to RYGB, DS provides superior resolution of diabetes, hypertension, and dyslipidemia in the super-obese independent of weight loss. | 19937190 |
| Nonalcoholic Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Weight Gain | Deregulated Nutrient Sensing | No recipient or donor factors were associated with disease recurrence, although patients with recurrent nonalcoholic steatohepatitis had a higher incidence of diabetes, weight gain, and dyslipidemia at the time of diagnosis of recurrence. | 19938117 |
| Obesity | Deregulated Nutrient Sensing | A better parameter in predicting insulin resistance: obesity plus elevated alanine aminotransferase. | 19938201 |
| Obesity | Deregulated Nutrient Sensing | Obesity and elevated ALT are associated with insulin resistance. | 19938201 |
| Sensorineural Hearing Loss (disorder), Dyslipidemias | Deregulated Nutrient Sensing | The role of dyslipidemia in sensorineural hearing loss in children. | 19939472 |
| Sensorineural Hearing Loss (disorder), Dyslipidemias | Deregulated Nutrient Sensing | When controlled for age and sex, no association between dyslipidemia and sensorineural hearing loss were found. | 19939472 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Consumption of sugar-sweetened beverages (SSBs) was related to an elevated risk of type 2 diabetes and insulin resistance in several recent studies among middle- or older-aged populations. | 19940226 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Primary prevention of smoking, dyslipidemia and overweight should be more aggressively promoted in adolescence. | 19942306 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased concentration of fibrinogen, dyslipidemia, and impaired fibrinolysis are regarded as important risk factors for CVD. | 19946236 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Both insulin resistance and increased oxidative stress in the liver are associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD). | 19946731 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidemia in behaviorally HIV-infected young women: Adolescent Trials Network study 021. | 19947855 |
| Inflammation, Dyslipidemias, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity, dyslipidemia, and inflammation were prominent among HIV-infected adolescent women and, coupled with other risk factors, may accelerate the lifetime risk of cardiovascular disease and other adverse events. | 19947855 |
| Dyslipidemias, Carotid Artery Diseases | Deregulated Nutrient Sensing | Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease. | 19951432 |
| Dyslipidemias, Carotid Artery Diseases | Deregulated Nutrient Sensing | We assessed the impact of 34 SNPs at 23 loci on dyslipidemia, key lipid sub-phenotypes, and severe carotid artery disease (CAAD) in a case-control cohort. | 19951432 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our analysis of 34 SNPs contributing to dyslipidemia at 23 loci suggests that genetic variation in the 1p13.3 region may increase risk of CAAD by increasing LDL particle number, whereas variation in the 19q13.2 region may increase CAAD risk by promoting formation of smaller, denser LDL particles. | 19951432 |
| Dyslipidemias, Ischemic stroke, diabetic | Deregulated Nutrient Sensing | Dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital. | 19951571 |
| Cerebrovascular Disorders, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidaemia is a potential independent risk factor for cerebrovascular disease in patients with diabetes. | 19951571 |
| Dyslipidemias, Ischemic stroke, diabetic | Deregulated Nutrient Sensing | The aim of this study was to investigate dyslipidaemia, treatment and control of dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital. | 19951571 |
| Dyslipidemias, diabetic, Cerebrovascular accident | Deregulated Nutrient Sensing | Diabetic patients suffering stroke displayed not only poorly-controlled lipid and lipoprotein profiles, including the significantly lower proportion of patients achieving intensified LDL-C target of < 2.07 mmol/L (80 mg/dl), and high density lipoprotein-cholesterol (HDL-C) target (14.4% vs 21.0%, P = 0.005; 45.8% vs 51.9%, P = 0.048 respectively), but also less adherence to therapy prescribed for dyslipidaemia (30.8% vs 41.0%, P = 0.001), when compared with diabetic patients without stroke. | 19951571 |
| Dyslipidemias, diabetic, Cerebrovascular accident | Deregulated Nutrient Sensing | For the diabetic women with stroke, situation of dyslipidaemia was worse, with significantly lower serum level of HDL-C and apoA1, higher LDL-C level and higher ratio of apoB/apoA1 when compared with diabetic counterparts without stroke. | 19951571 |
| Dyslipidemias, Ischemic stroke, diabetic | Deregulated Nutrient Sensing | Many diabetic patients with ischemic stroke remain uncontrolled for dyslipidaemia. | 19951571 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. | 19952033 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Measures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia. | 19952033 |
| Dyslipidemias, Endothelial dysfunction, Cardiovascular Diseases | Deregulated Nutrient Sensing | Protease inhibitors and other antiretroviral drugs have been associated with dyslipidemia, endothelial dysfunction, and increased cardiovascular disease risk. | 19952712 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Overall, the risk for type 2 diabetes or glucose intolerance (OR = 0.09, P = 0.022) and elevated blood pressure (OR = 0.46, P = 0.039) was decreased among the active cotwins. | 19952836 |
| Sleep Apnea, Obstructive, Glucose Intolerance (disease), Sleep Apnea, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Cross-sectional studies have documented the co-occurrence of obstructive sleep apnea (hereafter, sleep apnea) with glucose intolerance, insulin resistance, and type 2 diabetes mellitus (hereafter, diabetes). | 19958890 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings suggest that nicotinamide overload, which induced an increase in plasma N(1)-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. | 19960564 |
| Glucose Intolerance (disease), Coronary heart disease | Deregulated Nutrient Sensing | [Effect of renshen jianxin capsule for alleviating insulin resistance in patients with coronary heart disease and glucose tolerance impairment]. | 19960983 |
| Glucose Intolerance (disease), Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To explore the effect of Renshen Jianxin Capsule (RJC) on insulin resistance in patients with coronary heart disease (CHD) and glucose tolerance impairment (GTI). | 19960983 |
| Weight decreased, Osage language | Deregulated Nutrient Sensing | At 6 months, weight loss and improvements in OSA were accompanied by improved insulin resistance (HOMA), increased HDL cholesterol, and reduced total cholesterol/HDL ratio. | 19961024 |
| Sleep Apnea, CTCAE, Hypoxemia | Deregulated Nutrient Sensing | Improved insulin resistance was partly associated with reductions in liver fat and hypoxemia associated with sleep apnea. | 19961024 |
| Osage language, Dyslipidemias, Glucose Intolerance (disease), Obesity, Sleep Apnea, Obstructive, Hypertension, CTCAE | Deregulated Nutrient Sensing | Although obstructive sleep apnea (OSA) is strongly linked with obesity, both conditions have been associated with increased cardiovascular risk including glucose intolerance, dyslipidemia, and hypertension independent of one another. | 19961024 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. | 19961393 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance. | 19961393 |
| Menopause | Deregulated Nutrient Sensing | Menopause is a process closely related to insulin resistance and cardiovascular risk factors. | 19962253 |
| Hypotensive, Dyslipidemias | Deregulated Nutrient Sensing | Therefore, in addition to the well documented hypotensive effects of Hibiscus sabdariffa, we suggest the use of HSEP in individuals with dyslipidemia associated with MeSy. | 19962289 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, current dyslipidemia therapy substantially improved LDL cholesterol goal attainment in this cohort, but low HDL cholesterol levels were unaffected. | 19962476 |
| Increased insulin level | Deregulated Nutrient Sensing | We investigated the contribution of the cholinergic nervous system to dexamethasone-induced insulin resistance and hyperinsulinemia in rats. | 19962776 |
| Increased insulin level | Deregulated Nutrient Sensing | Vagotomy per se did not affect insulin resistance, but attenuated fasted and fed insulinemia in VAG DEX, compared with SHAM DEX rats. | 19962776 |
| SLC25A20 gene, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Several cross-sectional studies of general populations or high cardiovascular risk have shown that coronary calcium score (coronary artery calcium, CAC) was positively associated with traditional risk factors (hypertension, dyslipidemia, diabetes, and smoking) and some new risk factors (fibrinogen). | 19964672 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | PPARgamma and PGC-1alpha mRNA expression in both fat depots as well as in skeletal muscle is associated with markers of insulin resistance and cardiovascular risk. | 19966034 |
| Hyperlipidemia, Inflammation | Deregulated Nutrient Sensing | Our results indicate that improvement of insulin resistance, lipidemia, and blood pressure as well as reduction of systemic inflammation after bariatric surgery were associated with the increase of serum NO concentration. | 19997784 |
| Carcinogenic Chlorinated Hydrocarbon, hepcidin | Deregulated Nutrient Sensing | In patients with CHC, serum hepcidin correlated positively with aspartate aminotransferase (r = 0.334, P = 0.001) and insulin resistance (r = 0.27, P = 0.016) and had a trend for correlation with alanine aminotransferase (r = 0.197, P = 0.057) and serum haemoglobin (r = 0.188, P = 0.067) but not with ferritin. | 20002304 |
| Glucose Intolerance (disease), Polycythemia | Deregulated Nutrient Sensing | Glucose intolerance and activities of daily living were not directly associated with polycythemia after adjustment for sex. | 20002753 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with chronic kidney disease: a randomised controlled trial. | 20003316 |
| Inflammation | Deregulated Nutrient Sensing | Worryingly, recent observational data has highlighted an association between hypovitaminosis D and increased cardiovascular mortality, possibly mediated via vitamin D effects on insulin resistance and inflammation. | 20003316 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The main hypothesis of this study is that oral Vitamin D supplementation will ameliorate insulin resistance in patients with Chronic Kidney Disease stage 3 when compared to placebo. | 20003316 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | To date, no randomised controlled trial has been performed in pre-dialysis CKD patients to study the correlation between vitamin D status with supplementation, insulin resistance and markers of adverse cardiovascular risk. | 20003316 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Alcohol drinking in men with glucose intolerance was associated with a significant reduction in cardiovascular and all-heart disease mortality as seen in the general population in Japan. | 20004341 |
| Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response Terminology | Deregulated Nutrient Sensing | This preliminary study was therefore designed to test the hypothesis that DR is associated with insulin resistance and VFA in type 2 diabetes mellitus patients without insulin treatment. | 20004426 |
| GDC Disease Response Terminology | Deregulated Nutrient Sensing | Multivariate logistic analysis revealed that DR was independently predicted by high VFA and insulin resistance. | 20004426 |
| Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response Terminology | Deregulated Nutrient Sensing | The results of this preliminary study indicate that the presence of DR was associated with high VFA and insulin resistance in Japanese patients with type 2 diabetes mellitus. | 20004426 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | A growing body of evidence strongly supports associations between reduced lung function and insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. | 20006363 |
| Renal Insufficiency, Dyslipidemias, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | The growing population of elderly with chronic kidney disease (CKD) is at greater risk for cardiovascular disease given an independent risk of CKD, as well as from added dyslipidemia of aging and renal dysfunction. | 20006793 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Treatment of dyslipidemia in the general population suggests important benefits both in reducing cardiovascular risk and in the prevention of cardiovascular disease. | 20006793 |
| Kidney Failure, Chronic, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | However, randomized trials have yet to confirm similar benefits and targets of treatment for dyslipidemia in the elderly with CKD and end-stage renal disease. | 20006793 |
| Chronic Kidney Diseases, Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | There is a need for further specific investigation of dyslipidemia of CKD in the aging population in relation to renal disease progression and cardiovascular outcome. | 20006793 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Racial and ethnic differences in an estimated measure of insulin resistance among individuals with type 1 diabetes. | 20007942 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | OBJECTIVE Insulin resistance is greater in racial/ethnic minorities than in non-Hispanic whites (NHWs) for those with and without type 2 diabetes. | 20007942 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Because previous research on insulin resistance in type 1 diabetes was limited to NHWs, racial/ethnic variation in an estimated measure of insulin resistance in type 1 diabetes was determined. | 20007942 |
| Acanthosis Nigricans, Obesity | Deregulated Nutrient Sensing | Age-adjusted eGDR was negatively associated with body fat, triglycerides, urinary albumin/creatinine, acanthosis nigricans, parental obesity, and parental insulin resistance and positively related to HDL and sex hormone-binding globulin. | 20007942 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Patients with dyslipidemia and high overall risk of ischemic heart disease are those most likely to benefit from treatment with statins. | 20008151 |
| Hyperuricemia | Deregulated Nutrient Sensing | Genes responsible for insulin resistance could contribute to the development of hyperuricemia. | 20008926 |
| Hyperuricemia | Deregulated Nutrient Sensing | Previous cross-sectional studies have suggested ADRB3 as a possible candidate gene in the development of hyperuricemia and insulin resistance. | 20008926 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Little is known about how serum dioxins might affect insulin resistance, a hallmark of type 2 diabetes. | 20010210 |
| Obesity | Deregulated Nutrient Sensing | Obesity, the most common cause of insulin resistance (IR), can be diagnosed by body mass index (BMI). | 20011958 |
| Psoriasis, Dyslipidemias, Diabetes Mellitus, Depression, CTCAE, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Multivariate models controlling for age, gender and consulting behaviour indicated that psoriasis is independently associated with depression (OR 1.49; 95% CI 1.20-1.86), stress-related disorders (OR 1.41; 95% CI 1.22-1.62), behaviour disorders (OR 1.58; 95% CI 1.05-2.39), diabetes (OR 1.21 95% CI 1.04-1.40), hypertension (OR 1.34; 95% CI 1.18-1.51), dyslipidaemia (OR 1.29; 95% CI 1.07-1.55), and obesity (OR 1.63; 95% CI 1.39-1.90). | 20015170 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | In type 2 diabetic individuals rosuvastatin was less effective than simvastatin at improving endothelium-dependent vasodilation within one month, without affecting insulin-resistance, adiponectin levels and inflammation. | 20018286 |
| Obesity, Visceral, Diabetes Mellitus | Deregulated Nutrient Sensing | Increased production of these proinflammatory molecules by VAT may explain the links observed between visceral obesity, insulin resistance, and diabetes risk. | 20019678 |
| Overweight | Deregulated Nutrient Sensing | Triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL) >or=3.0 (in mg/dl) is a marker of insulin resistance in overweight persons. | 20019684 |
| Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | Leptin, visfatin, insulin resistance, and body composition change in chronic obstructive pulmonary disease. | 20021311 |
| Dyslipidemias, Anemia, Hyponatremia | Deregulated Nutrient Sensing | Dyslipidemia (73%), anemia (20%) and severe hyponatremia (13%) were found. | 20021371 |
| Obesity | Deregulated Nutrient Sensing | A low dietary intake of linoleic acid and elevated SCD-1 index may contribute to higher ALT activity in elderly men, even independently of obesity and insulin resistance. | 20022128 |
| Hyperglycemia, Hyperuricemia, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of hyperuricemia is low in Uygurs, who have a high prevalence of cardiovascular risk factors such as hypertension, overweight-obesity, dyslipidemia, hyperglycemia, and insulin resistance (IR). | 20029511 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The percentages of patients with comorbidities were 33.8% diabetes (2.5% type 1), 69% dyslipidemia, and 93% hypertension. | 20030520 |
| Atheroma, Diabetes Mellitus | Deregulated Nutrient Sensing | We investigated expression of lipogenic genes in human and rat arterial walls, its regulation in cultured VSMC and determined if it is modified during insulin-resistance and diabetes, situations with increased risk for atheroma. | 20030821 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | During insulin-resistance and diabetes, this expression is not increased and resists to the actions of glucose and ADM. | 20030821 |
| Atheroma, Diabetes Mellitus | Deregulated Nutrient Sensing | It is unlikely that this metabolic pathway contribute to lipid accumulation of arterial wall during insulin-resistance and diabetes and thus to the increased risk of atheroma observed in these situations. | 20030821 |
| Hypertension, CTCAE, Anemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustment for age, sex, body mass index, smoking, hypertension, dyslipidemia, diabetes duration, hemoglobin A1c, medication use (hypoglycemic, anti-hypertensive, lipid-lowering and anti-platelet drugs) and kidney function measures, the association of anaemia with all-cause (adjusted HR 2.11, 1.32-3.35, p=0.002) and cardiovascular mortality (adjusted HR 2.23, 1.12-4.39, p=0.020) remained statistically significant. | 20031129 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease. | 20031276 |
| Vascular Diseases, Cardiovascular Diseases, "Alzheimers Disease", Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance (IR) is the main pathological condition underlying vascular disorders, such as diabetes and cardiovascular disease, which are well established risk factors for cognitive decline and Alzheimer disease (AD). | 20031276 |
| Cardiovascular morbidity | Deregulated Nutrient Sensing | We hypothesized that this would also associate with metabolic phenotypes of insulin resistance and increased risk of cardiovascular morbidity and mortality. | 20031593 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | In risk allele carriers, a defective response of USF1 to insulin results in the suboptimal response of relevant target genes that contributes to the enhanced risk of developing dyslipidemia and coronary heart disease. | 20031629 |
| Shock, Myocardial Contraction, Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Independent predictors of increased risk of bleeding/VC in women included older age, shock, renal failure, presentation with non-ST-elevation myocardial infraction and larger sheath sizes, whereas the use of fluoroscopy-guided access, closure devices, history of dyslipidemia or prior PCI, and use of bivalirudin were protective. | 20031752 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Knowledge of heart disease risk among SHIELD respondents with dyslipidemia. | 20031839 |
| Heart Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Respondents in the US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) reported whether they had a diagnosis of dyslipidemia, were taking prescription dyslipidemia medication, and knew their heart disease risk (low, moderate, high, or do not know). | 20031839 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Of 7629 respondents with dyslipidemia, 35% reported not taking cholesterol medication, and 29% reported not knowing their heart disease risk. | 20031839 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | A large proportion of respondents with dyslipidemia did not know their heart disease risk. | 20031839 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | There is a gap in understanding and awareness of heart disease risk among respondents with dyslipidemia regardless of treatment status. | 20031839 |
| Hashimoto Disease, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, the prevalence of dyslipidemia increases along with hypofunction of the thyroid and T4 replacement therapy may improve lipid profile in the cases of SH with Hashimoto thyroiditis. | 20032565 |
| Dyslipidemias | Deregulated Nutrient Sensing | The most frequent dyslipidemia was low HDL-C followed by high triglycerides. | 20034514 |
| Dyslipidemias, Coast And Southern Tsimshian language, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Optimal BMI cut-offs for diabetes, hypertension, and dyslipidemia were much lower in Aborigines than the recommended WHO BMI cut-offs, while those in TSIs were around WHO BMI criteria. | 20034692 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Overall, 67% of patients were overweight or obese; obese and overweight patients were more likely to be female and have diabetes mellitus, hypertension, dyslipidemia, and less likely to be smokers. | 20034957 |
| Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Multiple logistic regression analysis showed that male gender, presence of obesity, hypertension, dyslipidemia, or Type 2 diabetes and elevated serum alanine transaminase activities were independent risk factors for the development of NAFLD. | 20036859 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no significant relationship between CMBs and the presence of diabetes mellitus and dyslipidemia. | 20037183 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | After adjusting for traditional cardiovascular risk factors and insulin resistance, the odds ratios [OR (95% CI)] of thicker IMT (> or =1.0 mm), higher PWV (> or =14.0 m/s) and low ABI (< or =1.0) for MetS were significantly increased [2.28 (1.19-4.38), 2.17 (1.36-3.46) and 1.72 (1.14-2.59), respectively, all P < 0.01] but were lower than the adjusted OR for those with three or more MetS components. | 20039893 |
| ETV3 wt Allele, Atherosclerosis | Deregulated Nutrient Sensing | MetS was associated with subclinical atherosclerosis independent of insulin resistance. | 20039893 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is associated with high blood glucose in the context of insulin resistance and relative insulin deficiency. | 20040363 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | In 2007 and 2008, all cases had dyslipidaemia (LDL > 100 mg/dL) and were hypertensive. | 20043534 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Concurrent diseases included hypertension, dyslipidemia and diabetes, respectively. | 20043561 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Decreased NKCC1 activity in erythrocytes from African Americans with hypertension and dyslipidemia. | 20044742 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | NKCC1 activity is lower in erythrocytes of African Americans with essential hypertension and dyslipidemia than in Caucasian counterparts. | 20044742 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, lung function impairment is also associated with insulin resistance and type 2 diabetes mellitus. | 20045536 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Visfatin genotype may modify the insulin resistance and lipid profile in type 2 diabetes patients. | 20046156 |
| Dyslipidemias, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus. | 20047560 |
| Proteinuria, Dyslipidemias, Dysglycemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Individuals were identified by Third Report of the National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP III) criteria (dysglycemia, hypertension, and dyslipidemia) and World Health Organization criteria (obesity and proteinuria). | 20047632 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Multivariate regression analysis showed that circulating sLR11 is independent contributing factor for the OCS, as well as diabetes mellitus and dyslipidemia. | 20047743 |
| Perivascular Epithelioid Cell Neoplasms, Neoplasms | Deregulated Nutrient Sensing | Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors. | 20048174 |
| Neoplasms | Deregulated Nutrient Sensing | Tumors were assessed for immunohistochemical evidence of mTORC1 activation and genetic evidence of alterations in TSC1 and TSC2. | 20048174 |
| Perivascular Epithelioid Cell Neoplasms | Deregulated Nutrient Sensing | PEComas demonstrated loss of TSC2 protein expression and evidence of baseline mTORC1 activation. | 20048174 |
| Perivascular Epithelioid Cell Neoplasms, Neoplasms | Deregulated Nutrient Sensing | CONCLUSION Inhibition of mTORC1, pathologically activated by loss of the TSC1/TSC2 tumor suppressor complex, is a rational mechanistic target for therapy in PEComas. | 20048174 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes (T2D) is a metabolic disorder characterized by disturbances of carbohydrate, fat and protein metabolism and insulin resistance. | 20049090 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The majority of T2D patients are obese and obesity by itself may be a cause of insulin resistance. | 20049090 |
| Obesity | Deregulated Nutrient Sensing | Visceral adiposity is closely correlated with neck circumference and represents a significant indicator of insulin resistance in WHO grade III obesity. | 20050862 |
| Obesity | Deregulated Nutrient Sensing | Visceral adiposity remains a strongly significant indicator of insulin resistance in WHO grade III obesity. | 20050862 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2. | 20056290 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | This association was independent of other cardiovascular risk factors but dyslipidemia (p = 0.002) that was not represented in AMI patients with II genotype and in a lower extent with hypertension (p < 0.05). | 20059382 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | There are seven human sirtuins (SIRT1-7), and SIRT1 has been implicated as a key mediator of the pathways downstream of calorie restriction that have been shown to delay the onset and reduce the incidence of age-related diseases such as type 2 diabetes. | 20061378 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increasing SIRT1 activity, either by transgenic overexpression of the Sirt1 gene in mice or by pharmacological activation by small molecule activators resveratrol and SRT1720, has shown beneficial effects in rodent models of type 2 diabetes, indicating that SIRT1 may represent an attractive therapeutic target. | 20061378 |
| Fat-free mass, Acromegaly, Somatotropin deficiency | Deregulated Nutrient Sensing | GH replacement decreased visceral adipose tissue, increased fat-free mass, decreased hsCRP, and improved quality of life in patients with GHD after cure of acromegaly, with minimal side effects and without an increase in insulin resistance. | 20061426 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Reduced serum levels of adiponectin have been associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD). | 20066503 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance and subclinical atherosclerosis are associated with SIRT1 downregulation in monocytes. | 20068143 |
| Cholelithiasis, Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Cholelithiasis and fatty liver disease share some important risk factors, such as central obesity, insulin resistance, and diabetes. | 20068558 |
| Steatohepatitis | Deregulated Nutrient Sensing | Consistent with the hypothesis that DBC1 is crucial for HFD-induced inhibition of SIRT1 and for the development of experimental liver steatosis, genetic deletion of Dbc1 in mice led to increased SIRT1 activity in several tissues, including liver. | 20071779 |
| Steatohepatitis | Deregulated Nutrient Sensing | These observations define what we believe to be a new role for DBC1 as an in vivo regulator of SIRT1 activity and liver steatosis. | 20071779 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidaemia and hypertension among adults with diabetes in rural Uganda. | 20075425 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidaemia and hypertension in patients with diabetes increase the risk of macrovascular and microvascular complications. | 20075425 |
| Dyslipidemias, Diastolic hypertension | Deregulated Nutrient Sensing | The prevalence of HDL and TG dyslipidaemia among the diabetics in Uganda is significantly higher than in non-diabetics, as is the prevalence of systolic and diastolic hypertension. | 20075425 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | The common mechanism linking MetS components to CVD risk through small- and large-artery dysfunctions may be mediated through metabolic factors related to insulin resistance, not to increased BP. | 20075933 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Risk factors for CAD were male gender, diabetes, dyslipidaemia and developing a cardiovascular condition disease during follow-up. | 20078615 |
| Alzheimers Disease | Deregulated Nutrient Sensing | These data suggest that resveratrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease. | 20080969 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The percentage of patients having two or three risk factors (such as dyslipidemia, hypertension, and DM) also increased with increased BMI. | 20081324 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | This occurred despite a postoperative reduction in endocrine pancreas mass, which may suggest the presence of insulin resistance and diabetogenic effect of pancreatic cancer. | 20084568 |
| Fibrosis, Liver | Deregulated Nutrient Sensing | Risk factors for advanced liver fibrosis in HIV-infected individuals: role of antiretroviral drugs and insulin resistance. | 20088890 |
| GTF2A1L wt Allele, Hepatitis C, Alcohol abuse | Deregulated Nutrient Sensing | Therefore, in addition to chronic hepatitis C and alcohol abuse, insulin resistance and/or exposure to dideoxy-nucleosides may contribute to ALF in HIV-infected patients. | 20088890 |
| Biliary calculi, Diabetes Mellitus, Non-Insulin-Dependent, Disease, Kidney Calculi | Deregulated Nutrient Sensing | Recent evidence suggests that gallstones and kidney stones are associated with insulin resistance, but the relation between stone diseases and the risk of developing type 2 diabetes mellitus is not clear. | 20089496 |
| Hyperuricemia, Gout | Deregulated Nutrient Sensing | The hyperuricemia in gout might be caused by the increased adiposity associated with insulin resistance. | 20091036 |
| Carcinogenesis | Deregulated Nutrient Sensing | The increased risk for table sugar suggests that insulin resistance may play a role in pancreatic carcinogenesis. | 20091114 |
| Prostate Cancer Outcomes Study, Endocrine System Diseases, Obesity, Hyperandrogenism, Anovulation, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. | 20092643 |
| Atherosclerosis of renal artery, Atherosclerosis | Deregulated Nutrient Sensing | Food intake patterns associated with carotid artery atherosclerosis in the Insulin Resistance Atherosclerosis Study. | 20092665 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Insulin resistance was associated with a 41% (95% confidence interval (CI) (1.07-1.87; p = 0.01) increased risk of overall cancer mortality. | 20094767 |
| Hyperglycemia, Primary malignant neoplasm | Deregulated Nutrient Sensing | In conclusion, hyperglycemia and insulin resistance may be 'high-risk' conditions for cancer mortality. | 20094767 |
| Microalbuminuria, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Compared with those without microalbuminuria (n = 73), NAFLD patients with microalbuminuria (n = 14) had significantly higher homeostasis model assessment of insulin resistance values (3.9 +/- 1.3 vs 5.8 +/- 3.7, P < .001). | 20096896 |
| Microalbuminuria, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These results indicate the presence of a significant association between the severity of insulin resistance and microalbuminuria in patients with NAFLD. | 20096896 |
| Nijmegen Breakage Syndrome | Deregulated Nutrient Sensing | By epistasis-like analysis through knockdown and use of mutant cells of distinct SIRT1 target proteins, we show that the non-homologous end joining (NHEJ) factor Ku70 as well as the Nijmegen Breakage Syndrome protein (nibrin) are not needed for this SIRT1-mediated effect, even though a partial contribution of nibrin cannot be excluded. | 20097625 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Strikingly however, the Werner helicase (WRN), which in its mutated form causes premature aging and cancer and which was linked to the Rad51-independent single-strand annealing (SSA) DSB repair pathway, is required for SIRT1-mediated HR. | 20097625 |
| hearing impairment, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We found no evidence suggesting that our observed relationship between diabetes and hearing impairment is due to hypertension or dyslipidemia. | 20097782 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Several rare single nucleotide polymorphisms (SNP) have been linked to diseases accompanying insulin resistance such as Type 2 diabetes, obesity, and dyslipidemia in different populations. | 20101100 |
| Hypertensive (finding), Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | PTP-1B polymorphisms contribute to pathogenesis of hypertension in Chinese subjects and PTP-1B SNP may be involved in the development of several features including dyslipidemia and obesity in hypertensive subjects. | 20101100 |
| Dyslipidemias | Deregulated Nutrient Sensing | Comparing NF with SCS patients, a significantly higher percentage of dyslipidemia was found in the group of SCS patients (50 vs 23%, P=0.033). | 20103607 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Subjects with glucose intolerance (i.e., IGT and T2DM) were older compared to subjects with NGT. | 20105040 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Adults with dyslipidemia (non-HDL-C >130 mg/dL and triglycerides [TG] > or =150 but < or =500 mg/dL) were randomly assigned in a 1:1:1 ratio to receive the FDC, atorvastatin 40 mg, or fenofibrate 145 mg for 12 weeks. | 20110022 |
| Hyperglycemia, Obesity, Visceral, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | the clustering of visceral obesity, dyslipidemia, hyperglycemia, and hypertension, has become a major public-health challenge worldwide. | 20110915 |
| physiopathological | Deregulated Nutrient Sensing | Although insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified. | 20111010 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | In animal models, defects of the aP2 gene (aP2(-/-)) partially protected against the development of obesity-related insulin resistance, dyslipidemia, and atherosclerosis. | 20111020 |
| Nonalcoholic Steatohepatitis, glycation, Dyslipidemias, Fatty Liver Disease | Deregulated Nutrient Sensing | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH. | 20112031 |
| Dyslipidemias, Fatty Liver Disease | Deregulated Nutrient Sensing | This study included 43 patients with biopsy-proven NASH with dyslipidemia. | 20112031 |
| Dyslipidemias, Fatty Liver Disease | Deregulated Nutrient Sensing | The present data demonstrated that atorvastatin decreased the serum levels of AGEs in NASH patients with dyslipidemia and suggest the usefulness of AGEs as a biomarker for the attenuation of NASH. | 20112031 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | Population mean total, low-density lipoprotein and high-density lipoprotein cholesterol (TC, LDL-C and HDL-C) and triglyceride (TG) concentrations, prevalence of dyslipidaemia, and treatment according to 2001 and 2005 Australian guideline target levels. | 20121678 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | CMRFCs included hypertension in addition to obesity, dyslipidemia, and diabetes. | 20122170 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | About 1 in every 4 patients (25.3%) had diabetes, and 60.7% had dyslipidemia. | 20122170 |
| Hypertensive (finding), Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | As compared to hypertensive patients without additional risk factors, adjusted odds ratios for BP control were significantly lower for all combinations of CMRFCs (ORs 0.15-0.83, all p < 0.04), with the exception of patients who had only dyslipidemia in addition to hypertension (OR = 1.09, p = NS). | 20122170 |
| Dyslipidemias, Intestinal Polyps | Deregulated Nutrient Sensing | A novel germline mutation in peroxisome proliferator-activated receptor gamma gene associated with large intestine polyp formation and dyslipidemia. | 20123124 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | The proband presented also dyslipidemia, hypertension and overweight, not associated to type 2 diabetes; of note, family members tested positive for the mutation and display only a dyslipidemic profile at variable penetrance with other biochemical parameters in the normal range. | 20123124 |
| Adenocarcinoma, Dyslipidemias, Colonic Polyps | Deregulated Nutrient Sensing | This is the first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma. | 20123124 |
| Noncommunicable Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia in newly diagnosed diabetes mellitus: the Jakarta primary non-communicable disease risk factors surveillance 2006. | 20124614 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia in subjects with newly diagnosed DM remains higher among all age groups than that in subjects without DM. | 20124614 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | the prevalence of dyslipidemia among subjects with newly diagnosed DM is higher than that in subjects without DM. | 20124614 |
| No metabolic abnormalities, Hypogonadism, Metabolic Syndrome X | Deregulated Nutrient Sensing | In this series of men with metabolic syndrome, hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities. | 20126854 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Alterations in blood glucose levels indicating the presence of glucose intolerance were identified in 11.5% of the population while 9.3% displayed overt diabetes. | 20128154 |
| Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Type B insulin resistance syndrome with systemic lupus erythematosus. | 20129024 |
| Unconscious State, Hypoglycemia | Deregulated Nutrient Sensing | He was admitted to the hospital because of unconsciousness and severe hypoglycemia in 2006, and was diagnosed as having Type B insulin resistance syndrome with the presence of insulin receptor antibody. | 20129024 |
| Proteinuria | Deregulated Nutrient Sensing | Early treatment with prednisolone might ameliorate proteinuria and insulin resistance. | 20129024 |
| Lupus Erythematosus, Systemic, Lupus Nephritis | Deregulated Nutrient Sensing | We experienced a rare case of Type B insulin resistance syndrome with increased activity of SLE, complicated with lupus nephritis. | 20129024 |
| Hypoglycemia, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | It appears that Type B insulin resistance syndrome should be suspected in differential diagnosis of hypoglycemia in SLE patients. | 20129024 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia and oxidative stress are causally related to atherogenesis and cardiovascular disease. | 20129371 |
| Steatohepatitis, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | No significant differences were observed with respect to sex, age, BMI, dyslipidemias, diabetes mellitus, arterial hypertension and hepatic steatosis. | 20129381 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Aldosterone production is associated with insulin resistance in obese and hypertensive subjects. | 20130077 |
| Autonomic neuropathy, diabetic | Deregulated Nutrient Sensing | Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean type 2 diabetic patients. | 20130937 |
| Hyperglycemia, Diabetic Neuropathies | Deregulated Nutrient Sensing | In addition to chronic hyperglycemia, insulin resistance itself has been proposed to cause a diabetic neuropathy. | 20130937 |
| Autonomic neuropathy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We evaluated the role of insulin resistance in the pathogenesis of peripheral and autonomic neuropathy in patients with type 2 diabetes. | 20130937 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Eighty-six patients with type 2 diabetes were evaluated for the anthropometric and biochemical profiles, and Kitt value was calculated from insulin tolerance test to assess the insulin resistance. | 20130937 |
| Hyperglycemia, Autonomic neuropathy, diabetic | Deregulated Nutrient Sensing | Insulin resistance is independently associated with peripheral and autonomic neuropathy in Korean Type 2 diabetic patients along with hyperglycemia and HDL-cholesterol. | 20130937 |
| Cessation of life | Deregulated Nutrient Sensing | The protein deacetylase SirT1 inhibits apoptosis in a variety of cell systems by distinct mechanisms, yet its role in chondrocyte death has not been explored. | 20131294 |
| Tumor necrosis | Deregulated Nutrient Sensing | Expression of SirT1 in chondrocytes led to increased chondrocyte survival in either the presence or the absence of tumor necrosis factor alpha/actinomycin D, while a reduction of SirT1 by siRNA led to increased chondrocyte apoptosis. | 20131294 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Examination of cartilage from normal donors and OA patients revealed that PTP1B levels are elevated in OA cartilage in which SirT1 levels are decreased. | 20131294 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | For the first time, it has been demonstrated that SirT1 is a mediator of human chondrocyte survival via down-regulation of PTP1B, a potent proapoptotic protein that is elevated in OA cartilage. | 20131294 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | It has been reported that diabetes mellitus (DM) is associated with poor pulmonary function, which could be explained by insulin resistance. | 20132629 |
| Microalbuminuria, Foot Ulcer, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | To examine the association of biochemical markers of risk (plasma Hcy, microalbuminuria, lipoprotein (a)(Lp(a)) and diabetic dyslipidaemia) with the prevalence of diabetic foot ulceration in type 2 diabetic patients. | 20135633 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Efficacy and safety of fenofibric acid co-administered with low- or moderate-dose statin in patients with mixed dyslipidemia and type 2 diabetes mellitus: results of a pooled subgroup analysis from three randomized, controlled, double-blind trials. | 20136164 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Monotherapy with lipid-modifying medication is frequently insufficient to normalize lipid abnormalities in patients with mixed dyslipidemia and type 2 diabetes mellitus. | 20136164 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with mixed dyslipidemia and type 2 diabetes (n = 586). | 20136164 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fenofibric acid + statin combination therapy in patients with mixed dyslipidemia and type 2 diabetes was well tolerated and resulted in more comprehensive improvement in the lipid/apolipoprotein profile than either monotherapy. | 20136164 |
| Hypertension, CTCAE, ras GTPase-Activating Proteins, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Greater Green Triangle Diabetes Prevention Program: remaining treatment gaps in hypertension and dyslipidaemia. | 20136814 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | [Correlations between adipocytokines and insulin resistance in women with polycystic ovary syndrome]. | 20137676 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | To investigate the correlations between adipocytokines and insulin resistance in women with polycystic ovary syndrome. | 20137676 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The higher levels of leptin and TNF-alpha, the lower level of adiponectin in obese PCOS and the higher level of TNF-alpha and IL-6 in non-obese PCOS suggested different adipocytokines play different roles of insulin resistance in PCOS. | 20137676 |
| Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | We think that colestimide therapy might provide a beneficial effect on atherosclerotic disease in diabetes mellitus with dyslipidemia through reduction of cholesterol and blood glucose. | 20139652 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Further studies in subjects with low serum 25(OH)D levels combined with impaired glucose tolerance, hypertension or dyslipidaemia are needed. | 20141565 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Potential mediators, including atherogenic dyslipidemia, insulin resistance, and inflammation, might underlie this association. | 20142527 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Atherogenic dyslipidemia, type 2 diabetes mellitus, and C-reactive protein level were potential mediators of this relation. | 20142527 |
| ADIPOQ protein, human, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes. | 20142631 |
| ADIPOQ protein, human | Deregulated Nutrient Sensing | The adiponectin-leptin ratio correlated best with the clamp derived sensitivity index (r=0.553, p<0.001) compared to other surrogate measures of insulin resistance. | 20142631 |
| ADIPOQ protein, human, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The adiponectin-leptin ratio is associated with insulin resistance, measured with the euglycemic hyperinsulinemic clamp, in Caucasians with T2D. | 20142631 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The adiponectin-leptin ratio promises to become a new laboratory marker of insulin resistance in T2D. | 20142631 |
| Hypertension, CTCAE, Prehypertension | Deregulated Nutrient Sensing | Insulin resistance and prevalence of prehypertension and hypertension among community-dwelling persons. | 20145357 |
| Hypertension, CTCAE, Prehypertension | Deregulated Nutrient Sensing | Insulin resistance was significantly associated with prehypertension as well as hypertension in the general population. | 20145357 |
| Glucose Intolerance (disease), Cystic Fibrosis | Deregulated Nutrient Sensing | Low prevalence of glucose intolerance in racially mixed children with cystic fibrosis. | 20149123 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Although not conclusive, these data suggest that in addition to age, the genotype:phenotype ratio may influence the development of glucose intolerance in patients with CF. | 20149123 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in the Punjab Province of Pakistan. | 20149776 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Overall total glucose intolerance (diabetes and IGT) was present in 16.68% males and 19.37% females. | 20149776 |
| Hypogonadism, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | To investigate the effect of testosterone treatment on insulin resistance, glycemic control, and dyslipidemia in Asian Indian men with type 2 diabetes mellitus (T2DM) and hypogonadism. | 20150021 |
| Non-alcoholic Fatty Liver Disease, Weight decreased, Dyslipidemias | Deregulated Nutrient Sensing | Of these 25 subjects, 9 diagnosed as having nonalcoholic fatty liver disease (which is highly prevalent in obese individuals and strongly associated with dyslipidemia) underwent a weight loss program. | 20150556 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | Recently, a novel rehabilitation exercise method, low-intensity RE, combined with blood flow restriction (BFR), has been shown to stimulate mammalian target of rapamycin complex 1 (mTORC1) signaling and MPS in young men. | 20150565 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | We hypothesized that low-intensity RE with BFR would be able to activate mTORC1 signaling and stimulate MPS in older men. | 20150565 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | We measured MPS and mTORC1-associated signaling proteins in seven older men (age 70+/-2 yr) before and after exercise. | 20150565 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | We conclude that low-intensity RE in combination with BFR enhances mTORC1 signaling and MPS in older men. | 20150565 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and, therefore, risk for cardiovascular diseases were high during the use of highly active antiretroviral therapy. | 20151093 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was defined as TG >or=1.70 mmol/L or HDL-C | 20156073 |
| TG gene, Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Men on antihypertensive medication had no increased risk of IHD mortality compared to untreated normotensive men, provided they were free from high TG and low HDL-C dyslipidemia. | 20156073 |
| Hepatitis C | Deregulated Nutrient Sensing | Reduction of insulin resistance with effective clearance of hepatitis C infection: results from the HALT-C trial. | 20156586 |
| Communicable Diseases, Hepatitis C, Diabetes Mellitus | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) infection is associated with an increased prevalence of diabetes and insulin resistance (IR); whether this is a causal relationship has not been established. | 20156586 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lipotoxicity (increased tissue fat content) has been implicated in the development of muscle insulin resistance and type 2 diabetes mellitus (T2DM). | 20157197 |
| cervical cancer | Deregulated Nutrient Sensing | Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells. | 20157519 |
| cervical cancer | Deregulated Nutrient Sensing | We now present evidence that SIRT1, an aging-related NAD-dependent deacetylase, mediates HPV E7 survival function in SiHa cervical cancer cells. | 20157519 |
| Weakness, Cachexia, Muscle (organ) | Deregulated Nutrient Sensing | The clinical consequences of bedrest may mimic those of cachexia, including rapid loss of muscle, insulin resistance, and weakness. | 20164314 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Thus, this study aims to investigate if coffee use has any relationship with bright liver, measured by ultrasound bright liver score (BLS), in patients with non-alcoholic fatty liver disease (NAFLD), and which relationship, if any, is present with BMI and insulin resistance. | 20165979 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Odds ratios show that obesity, higher insulin resistance, lower HDL cholesterol, older age and arterial hypertension are associated with a greater risk of more severe BLS; to the contrary, coffee drinking is associated with less severe BLS. | 20165979 |
| Obesity | Deregulated Nutrient Sensing | Coffee use is inversely associated with the degree of bright liver, along with insulin resistance and obesity, which, to the contrary, are directly associated with greater likelihood and severity of bright liver appearance. | 20165979 |
| Liver carcinoma, Non-alcoholic Fatty Liver Disease, Overweight, Liver Cirrhosis | Deregulated Nutrient Sensing | A possible opposite, if not antagonistic, role of coffee with regard to overweightness and insulin resistance, similar to that reported in hepatocarcinoma and cirrhosis, is envisaged in the natural history of NAFLD. | 20165979 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The pathophysiology underlying the association between hypertension and insulin resistance remains unclear. | 20167040 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These capillaroscopy data demonstrated an association with SBP but not insulin resistance, suggesting that capillary measures are unlikely to explain the association between hypertension and insulin resistance, at least with modest degrees of blood pressure elevation. | 20167040 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Normalization of glucose intolerance in first-degree relatives of patients with type 2 diabetes. | 20167387 |
| Cessation of life | Deregulated Nutrient Sensing | We show that knockdown of endogenous DYRK1A and DYRK3 leads to hypophosphorylation of SIRT1, sensitizing cells to DNA damage-induced cell death. | 20167603 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Telomere length in relation to insulin resistance, inflammation and obesity among Arab youth. | 20178511 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The prevalence of population-wide hypertension, obesity and dyslipidemia has not been well studied in the pasture area of Xinjiang. | 20178648 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension. | 20179633 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To perform a two-stage study to explore the role of gene variants in the risk of insulin resistance and arterial hypertension. | 20179633 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Arteriosclerotic risk factors included age, hypertension, dyslipidemia, type 2 diabetes mellitus, and smoking. | 20180401 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The G1057D polymorphism in the insulin receptor substrate-2 (IRS-2) gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes. | 20184486 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | In conclusion, patients with ALS show abnormal glucose tolerance that could be associated with increased FFA levels, a key determinant of insulin resistance. | 20184518 |
| Osteoporosis, Cushing Syndrome, Dyslipidemias, Obesity, Saint Helena Islands, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Spinal Fractures | Deregulated Nutrient Sensing | Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidaemia, central obesity, osteoporosis and vertebral fractures. | 20184600 |
| Sleep Apnea, Obstructive, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obstructive sleep apnea is common in patients with type 2 diabetes, and its association with insulin and insulin resistance has been examined in cross-sectional studies. | 20185739 |
| Triglycerides | Deregulated Nutrient Sensing | After accounting for adiposity, other risk factors were high insulin, insulin resistance, high triglycerides, and smoking, factors amenable to lifestyle intervention. | 20185739 |
| Weight decreased | Deregulated Nutrient Sensing | Both weight loss and ezetimibe plus weight loss significantly (all P < 0.05) reduced body weight, visceral and subcutaneous adipose tissues, insulin resistance and plasma triglycerides, VLDL-apoB-100, apoC-III, fetuin-A, and retinol-binding protein-4 and increased plasma adiponectin concentrations. | 20185740 |
| Inflammation, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. | 20185740 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Depression and insulin resistance: cross-sectional associations in young adults. | 20185745 |
| Depressive disorder | Deregulated Nutrient Sensing | In unadjusted models mean insulin resistance was 17.2% (95% CI 0.7-36.0%, P = 0.04) higher in men and 11.4% (1.5-22.0%, P = 0.02) higher in women with depressive disorder. | 20185745 |
| Depressive disorder | Deregulated Nutrient Sensing | After adjustment for behavioral and dietary factors, the increased level of insulin resistance associated with depressive disorder was 13.2% (-3.1 to 32.3%, P = 0.12) in men and 6.1% (-4.1 to 17.4%, P = 0.25) in women. | 20185745 |
| Depressive disorder | Deregulated Nutrient Sensing | A positive association was found between depressive disorder and insulin resistance in this population-based sample of young adult men and women. | 20185745 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Older age and the presence of diabetes, hypertension and dyslipidaemia were significantly associated with CKD in all ethnic groups. | 20185856 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes (45%) and dyslipidaemia (16%) among Malays and hypertension among Indians (23%) had greater population-attributable risk of CKD. | 20185856 |
| Obesity, Dyslipidemias, Hypertension, CTCAE, Hypothyroidism | Deregulated Nutrient Sensing | Of the patients, 400 (40%) were diagnosed with dyslipidemia and hypertension (p = 0.002), 160 (16%) with obesity and 80 (8%) with hypothyroidism. | 20186515 |
| Obesity | Deregulated Nutrient Sensing | The mechanism is unclear, and central (visceral) obesity, insulin resistance, altered sex steroids and altered adipokines are mooted as possible factors. | 20189371 |
| Lupus Erythematosus | Deregulated Nutrient Sensing | Type B insulin resistance complicated with systemic lupus erythematosus. | 20190490 |
| Disease | Deregulated Nutrient Sensing | This is a rare and important case report showing a clear correlation between anti-insulin receptor autoantibodies of type B insulin resistance and SLE disease activity. | 20190490 |
| Discordance, Hypercholesterolemia, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Hypercholesterolemia was a predominant expression of dyslipidemia in discordance with literature dates for diabetic patient. | 20191816 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Recent data suggest that clearance of UA is being reduced with increase in insulin resistance and UA as a marker of prediabetes period. | 20192932 |
| Dyslipidemias | Deregulated Nutrient Sensing | The main risk factors of T2DM chronic complications seemed to be related to high CRP, dyslipidemia, high BUN and high LDL-C. | 20193318 |
| Atherosclerosis | Deregulated Nutrient Sensing | Adipocyte fatty acid-binding protein (A-FABP) has been shown to have an effect on insulin resistance, lipid metabolism, and atherosclerosis in animals. | 20193950 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Dietary intake and serum and hair concentrations of minerals and their relationship with serum lipids and glucose levels in hypertensive and obese patients with insulin resistance. | 20195917 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Forty obese hypertensive subjects with insulin resistance and 40 healthy volunteers were recruited in the study. | 20195917 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The obtained results seem to indicate the association between lipid and glucose metabolism and iron, copper, zinc, and calcium concentrations in blood and hair of hypertensive and obese patients with insulin resistance. | 20195917 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is an important risk factor for myocardial infarction (MI). | 20198310 |
| 21-hydroxylase deficiency | Deregulated Nutrient Sensing | Functional laboratory tests ruled out heterozygous C21-hydroxylase deficiency and showed a moderate insulin resistance on the oral glucose tolerance test. | 20198556 |
| AHSG protein, human, Diabetes Mellitus | Deregulated Nutrient Sensing | Fetuin-A is a liver-derived factor that may play a role in insulin resistance and age-related chronic diseases (eg, type 2 diabetes mellitus and cardiovascular [CV] disease). | 20199782 |
| Inflammation | Deregulated Nutrient Sensing | In addition to their expected effects on lipid profile, lipid-lowering agents may reduce cardiovascular events because of effects on nonclassic risk factors such as insulin resistance and inflammation. | 20199786 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The relationship of CVD to population variation in dyslipidemia and body composition needs further study, particularly in populations where the burden of cardiovascular and metabolic disease is rapidly increasing. | 20199988 |
| diabetic | Deregulated Nutrient Sensing | When corrected for alterations in insulin resistance, the change in insulin secretion remained significant only in the obese-type 2 diabetic group (1.23 +/- 0.26 vs. 2.04 +/- 0.46 arbitrary units; P < 0.01). | 20200305 |
| Endothelial dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Endothelial dysfunction is frequently present in individuals with insulin resistance or type 2 diabetes and can be induced by high-fat or high-carbohydrate meals. | 20200309 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2. | 20204253 |
| Weight decreased | Deregulated Nutrient Sensing | In the weight loss study, the increase in circulating osteocalcin concentration (+70.6 +- 29.3 vs. +32 +- 13.5%, p = 0.021) was significantly greater in subjects with the highest decrease in ALT levels, despite similar baseline BMI, insulin resistance and degree of weight loss than remaining subjects. | 20204603 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance in subjects not previously diagnosed with diabetes was categorized according to 2003 American Diabetes Association criteria. | 20206389 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Previous studies have reported that statin use was associated with reductions in cardiovascular morbidity and mortality among patients with dyslipidemia, even without established cardiovascular disease. | 20206788 |
| Degenerative polyarthritis, Osteoporosis, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most frequent were systemic arterial hypertension (56.7%), osteoporosis (23.3%), osteoarthritis (21.2%) and dyslipidemia (20%). | 20209343 |
| Impaired cognition, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Overweight, Cardiac Arrhythmia | Deregulated Nutrient Sensing | We found correlation between some risk factors and cognitive impairment / depression (hypertension, overweight, dyslipidemia, diabetes, arrhythmia, carotid system lesion). | 20209767 |
| Microalbuminuria, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Kidney function [estimated glomerular filtration rate (e-GFR) by two well-established equations and creatinine clearance], HDL-C, triglycerides, apoA-I and insulin resistance (HOMAir) were measured in 2,484 fasting subjects (e-GFR>or=45 ml/min/1.73 m2) without macroalbuminuria, cardiovascular disease, diabetes, or the use of anti-hypertensives and/or lipid-lowering agents. | 20211930 |
| Gout | Deregulated Nutrient Sensing | [Effects of serial gout granules on insulin-resistance in primary gout patients]. | 20214324 |
| Primary gout, Gout | Deregulated Nutrient Sensing | To clarify the correlation between primary gout and insulin-resistance (IR), and to observe the effect of serial gout granules (SGGs) on IR in patients with primary gout. | 20214324 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | One of the factors involved in type 2 diabetes in males is a reduction in levels of testosterone, which has been shown to predict resistance to insulin and the development of cardiovascular diseases. | 20214724 |
| Primary malignant neoplasm, Cachexia, Anorexia | Deregulated Nutrient Sensing | Anorexia, cachexia, and insulin resistance are commonly seen in patients with cancer. | 20215915 |
| Weight decreased, Cachexia | Deregulated Nutrient Sensing | The objective of this study was to determine the levels of adipokines and their relation to appetite, weight loss, insulin resistance, and other hormones in cancer cachexia. | 20215915 |
| Primary malignant neoplasm, Cachexia | Deregulated Nutrient Sensing | Leptin levels were significantly decreased in cancer cachexia and were directly associated with appetite and insulin resistance, explaining 37% and 19% of the variance seen in cancer patients, respectively. | 20215915 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Leptin may play a role in the increased insulin resistance seen in cancer patients. | 20215915 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Insulin resistance independently influences arterial stiffness in normoglycemic normotensive postmenopausal women. | 20215975 |
| Arterial Stiffness, Cardiovascular Diseases, Atherosclerosis | Deregulated Nutrient Sensing | Cardiovascular disease risk increases after menopause, which may be related to insulin resistance, and arterial stiffness is a significant predictor of atherosclerosis. | 20215975 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of hypertension, dyslipidaemia and diabetes was 17.3%, 66.3% and 5.6% respectively. | 20218138 |
| leukemia | Deregulated Nutrient Sensing | Moreover, we found that blockade of mTORC1 by RAD001 synergistically enhanced the action of AZD6244 in leukemia cells. | 20221697 |
| Ischemic stroke, White matter lesions | Deregulated Nutrient Sensing | Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke. | 20223079 |
| Cerebral white matter lesions, Ischemic stroke | Deregulated Nutrient Sensing | We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke. | 20223079 |
| Ischemic stroke, White matter lesions | Deregulated Nutrient Sensing | It was found that insulin resistance correlated with white matter lesions among non-diabetic patients with non-cardiogenic ischemic stroke. | 20223079 |
| Inflammation | Deregulated Nutrient Sensing | These findings suggest that serum biomarkers of insulin resistance and inflammation may be predictive of clinical outcomes following LEB. | 20223619 |
| Inflammation | Deregulated Nutrient Sensing | Improving the systemic milieu of insulin resistance and inflammation in these high-risk patients may lead to reduced morbidity and mortality. | 20223619 |
| Inflammation, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Since atherosclerosis is a multifactorial disease, the aim of this study was to determine association between hsCRP and other markers of inflammation and dyslipidemia. | 20225663 |
| Reduced | Deregulated Nutrient Sensing | They confirm that treatment of insulin resistance decreases T production in this population and demonstrate that pharmacologic lowering of T does not affect insulin resistance. | 20226444 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population. | 20233452 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4) has been reported to be involved in the development of insulin resistance and diabetes. | 20233518 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Metabolic syndrome is a well-known cardiovascular risk factor closely related to increased insulin resistance. | 20233530 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Cigarette smoking, obesity, and dyslipidemia were the most important modifiable risk factors in young patients with STEMI. | 20235218 |
| Diabetic Nephropathy, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia may be a risk factor for diabetic kidney disease. | 20236720 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Atorvastatin causes insulin resistance and increases ambient glycemia in hypercholesterolemic patients. | 20298928 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Despite beneficial reductions in LDL cholesterol and apolipoprotein B, atorvastatin treatment resulted in significant increases in fasting insulin and glycated hemoglobin levels consistent with insulin resistance and increased ambient glycemia in hypercholesterolemic patients. | 20298928 |
| Gall Bladder Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Chronic disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease. | 20301983 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Insulin resistance and lower plasma adiponectin increase malignancy risk in nondiabetic continuous ambulatory peritoneal dialysis patients. | 20303125 |
| palladium, Malignant Neoplasms | Deregulated Nutrient Sensing | These findings demonstrate that insulin resistance and lower adiponectin levels could be risk factors for malignancy in nondiabetic PD patients. | 20303125 |
| Decreased LDL cholesterol concentration | Deregulated Nutrient Sensing | Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. | 20303351 |
| Steatohepatitis | Deregulated Nutrient Sensing | Hepatic steatosis is associated with insulin resistance, but it is not clear whether increased intrahepatic triglyceride (IHTG) content causes the resistance or is a marker. | 20303351 |
| Familial hypobetalipoproteinemia, Fatty degeneration, physiopathological | Deregulated Nutrient Sensing | Steatosis is dissociated from insulin resistance in FHBL, which suggests that increased IHTG content is a marker, not a cause, of metabolic dysfunction. | 20303351 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Effects of omega-3 polyunsaturated fatty-acid supplementation on redox status in chronic renal failure patients with dyslipidemia. | 20303788 |
| Cancer-related fatigue, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | We sought to evaluate the effects of omega-3 polyunsaturated fatty-acid (PUFA) supplementation on dyslipidemia, lipid and protein peroxidation, and antioxidant defense in patients with chronic renal failure (CRF). | 20303788 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | They presented with dyslipidemia and hypertriglyceridemia (triacylglycerols, >1.7 mmol/L) and/or hypercholesterolemia (total cholesterol, >5 mmol/L). | 20303788 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | The prevalence of insulin resistance and cardiovascular disease (CVD) increases with degree of obesity. | 20304617 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | BMI is at least comparable to WC in stratifying individuals for prevalence of metabolic abnormalities associated with increased CVD risk and predicting insulin resistance. | 20304617 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on insulin resistance and adipocytokines in patients with diabetes mellitus type 2. | 20329566 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This polymorphism could be associated with insulin resistance and adipocytokines in patients with diabetes mellitus type 2. | 20329566 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of our study was to investigate the influence of Thr54 polymorphism in the FABP2 gene on adipocytokines and insulin resistance in the fasted state in naive patients with diabetes mellitus type 2. | 20329566 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In men, 25-OH-D levels were lower in those with glucose intolerance than normoglycemia (P = 0.01). | 20332348 |
| Obesity | Deregulated Nutrient Sensing | Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. | 20335544 |
| Obesity | Deregulated Nutrient Sensing | Replication of our findings and further in-depth studies of dietary patterns that modify SIRT1 may lead to clinical studies of dietary modification of SIRT1 to influence obesity. | 20335544 |
| Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | Hypertension was present as a preoperative risk factor in most patients (74.2%); dyslipidemia was present in 51.6%, diabetes mellitus in 38.7%, stroke in 73%, and renal failure in 2.4%. | 20336998 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | As for glucose and lipid metabolism, homeostasis model assessment insulin resistance (HOMA-R) level in the non-diabetic group and triglyceride in the diabetes group were significantly lower with cilnidipine than with amlodipine. | 20337636 |
| Dyslipidemias, Demographics Domain, HPT gene, GDC Disease Response Terminology | Deregulated Nutrient Sensing | Duration of DM, HPT and presence of DN were associated with DR. HPT and dyslipidemia were associated with DN. | 20339790 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | HIV infection is associated with dyslipidaemia, and becomes increasingly debilitating as immunodeficiency progresses. | 20345886 |
| Rheumatoid Arthritis, Obesity, Abdominal | Deregulated Nutrient Sensing | Visfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in women with rheumatoid arthritis. | 20346233 |
| Obesity, Abdominal, Refractory anemias, Rheumatoid Arthritis, Obesity, Overweight | Deregulated Nutrient Sensing | The increasing incidence of overweight and obesity in modern societies, and the demonstration that adipose tissue produces numerous cytokines, increases interest of investigators in the associations between adipose tissue, adipokines, CRP and insulin resistance in rheumatoid arthritis (RA) and their possible role in the pathogenesis of this disease.The purpose of the study was to investigate serum levels of visfatin, resistin, hsCRP and insulin resistance in relation to abdominal obesity in patients with RA. | 20346233 |
| Refractory anemias | Deregulated Nutrient Sensing | Visfatin as well as resistin did not correlate with anthropometric parameters or insulin resistance in whole patients with RA. | 20346233 |
| Proteinuria | Deregulated Nutrient Sensing | After the study, ADMA, sFas, myostatin, insulin resistance, high-sensitive C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), blood pressure and proteinuria levels were decreased, and FMD and serum albumin levels increased (P < 0.05 for all). | 20348148 |
| Cardiovascular Diseases, Refractory anemias, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Rheumatoid Arthritis | Deregulated Nutrient Sensing | To determine the proportion of rheumatoid arthritis (RA) patients receiving preventive health care according to US Preventive Services Task Force recommendations compared with a community-based population sample, with emphasis on dyslipidemia testing, given the increased risk of cardiovascular disease (CVD) in RA patients. | 20349066 |
| Refractory anemias, Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | Patients with RA were more likely to have had dyslipidemia and osteoporosis testing compared with the general population (86 vs. 75 and 75 vs. 55%, respectively, P < 0.0001 for both). | 20349066 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | The RA patients with traditional cardiovascular risk factors are more likely to be tested for dyslipidemia. | 20349066 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A prospective trial of U500 insulin delivered by Omnipod in patients with type 2 diabetes mellitus and severe insulin resistance. | 20350913 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To test the effectiveness and safety of U500 regular insulin delivered by continuous subcutaneous insulin infusion (CSII) via the Omnipod insulin delivery system in patients with uncontrolled type 2 diabetes mellitus and severe insulin resistance. | 20350913 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In CRI groups, patients were older and had a higher prevalence of hypertension, diabetes mellitus, and dyslipidemia. | 20360292 |
| Dyslipidemias, Diabetes Mellitus, Degenerative polyarthritis, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Indeed, OA has been linked not only to obesity but also to other cardiovascular risk factors, namely, diabetes, dyslipidemia, hypertension, and insulin resistance. | 20367223 |
| Dyslipidemias, Psoriasis, Obesity | Deregulated Nutrient Sensing | Patients with psoriasis have reported to have cardiometabolic disturbances including obesity, insulin resistance, and dyslipidemia. | 20367239 |
| Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is significantly associated with coronary artery disease and cardiovascular events in patients with or without type 2 diabetes mellitus. | 20368081 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in chronic inflammation, insulin resistance and atherosclerosis. | 20368224 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This observation strongly supports the implication of the PPARG Pro12Ala in insulin resistance and T2D in a Russian population. | 20368233 |
| Hypertensive (finding), Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The authors analyse effect of GPIIIA gene (PI a allele) polymorphism on the frequency of complicated coronary heart disease in patients with dyslipidemia and hypertensive disease. | 20369606 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | SIRT1 which has a role in ageing and cancer and is known to regulate p53 signaling through acetylation. | 20370686 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance was significantly associated with steatosis, fibrosis, hepatocellular ballooning, NAS, and NAFLD pattern. | 20372110 |
| Non-alcoholic Fatty Liver Disease, ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | Individual MetS features, particularly central obesity and insulin resistance, were also associated with severity of NAFLD. | 20372110 |
| Disease of capillaries, diabetic | Deregulated Nutrient Sensing | Insulin resistance is associated with microangiopathy in type 1 diabetic patients treated with intensive insulin therapy from the onset of disease. | 20373280 |
| Hyperphagia | Deregulated Nutrient Sensing | Forced expression of wild-type Sirt1 in the mediobasal hypothalamus by adenovirus microinjection suppressed Foxo1-induced hyperphagia, a model for central insulin resistance. | 20375183 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Pharmacological activators of Sirt1 have been reported to increase the life span and improve the health of mice fed a high-fat diet and to reverse diabetes in rodents. | 20375183 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients. | 20376890 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The aim of this study was to determine whether retinol-binding protein 4 (RBP4), adiponectin and high molecular weight (HMW) adiponectin are associated with insulin resistance (IR) and metabolic parameters in non-diabetic hypertensive patients. | 20376890 |
| Malnutrition | Deregulated Nutrient Sensing | Relationship of insulin resistance in chronic haemodialysis patients with inflammatory indicators, malnutrition, echocardiographic parameters and 24 hour ambulatory blood pressure monitoring. | 20377496 |
| Fluid overload, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The decrease in ISI-S along with the hypervolaemia suggests that volume overload is a contributory factor in the pathogenesis of insulin resistance in patients with chronic renal failure. | 20377496 |
| Fluid overload | Deregulated Nutrient Sensing | This study indicates that, in addition to the traditional cardiovascular risk factors in these patients, insulin resistance can be regarded as a risk factor, but not an independent one, mainly a reflection of the underlying culprit, hypervolaemia. | 20377496 |
| Inflammation, Dyslipidemias, PEELING SKIN SYNDROME | Deregulated Nutrient Sensing | The presence of dyslipidemia in pSS was associated with increased ESR (44.05+/-28.07 versus 28.28+/-18.00, P=0.03), but not with other laboratory markers of the disease and inflammation. | 20378384 |
| Kidney Failure, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis. | 20378825 |
| Feeding behaviors | Deregulated Nutrient Sensing | Thus, insulin resistance in CP patients seems to affect eating behavior by affecting meal responses of gut peptides. | 20379145 |
| Malnutrition, Dyslipidemias | Deregulated Nutrient Sensing | Serum beta(2)-microglobulin was associated with longer duration on hemodialysis, malnutrition inflammation (lower serum albumin and higher high-sensitivity C-reactive protein) and dyslipidemia. | 20379193 |
| Dyslipidemias, Chronic disease, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | As many as 78.6% used medications and 82.1% admitted to suffering from some non-transmissible chronic disease, the most frequent being hypertension (56.4%), dyslipidaemia (33.3%) and diabetes mellitus (20.5%). | 20379660 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These results indicate that in addition to involvement in insulin resistance, impaired function of mesenchymal stem cells that reside in adipose tissue as one of the major sources of adult stem cells might be responsible for complications related to diabetes type 2. | 20380516 |
| Obesity | Deregulated Nutrient Sensing | The increased expression of myostatin, a secreted anabolic inhibitor of muscle growth and development, has been associated with obesity and insulin resistance. | 20386333 |
| Inflammation, Hypoxia, Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Because mitochondrial dysfunction, inflammation, endoplasmic-reticulum stress and hypoxia all inactivate mTORC1, our results may suggest a unifying mechanism for the pathogenesis of insulin resistance in T2D, although the underlying causes might differ. | 20386866 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined insulin signaling in adipocytes from T2D patients, and contrary to findings in animal studies, we observed attenuation of insulin activation of mammalian target of rapamycin (mTOR) in complex with raptor (mTORC1). | 20386866 |
| Diastolic dysfunction, Hyperglycemia | Deregulated Nutrient Sensing | Hyperglycaemia and insulin resistance have been linked to diastolic dysfunction experimentally. | 20386878 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alterations of insulin resistance and the serum adiponectin level in patients with type 2 diabetes mellitus under the usual antihypertensive dosage of telmisartan treatment. | 20388049 |
| Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance plays a central role in the pathophysiology of diabetes complications. | 20388049 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The data indicate that the usual antihypertensive dosage of telmisartan improves insulin resistance and changes adiponectin effect in patients with diabetes mellitus. | 20388049 |
| Impaired cognition | Deregulated Nutrient Sensing | However, the link between elevated fasting glucose levels and insulin resistance in nondiabetic individuals, and the risk of cognitive impairment is unclear. | 20393152 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated fasting glucose levels and insulin resistance are not associated with worse cognitive function in older people without a history of diabetes. | 20393152 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To study the association of various systemic risk factors with retinal hard exudates in type 2 diabetic north Indian patients and to measure the incidence of dyslipidemia in them. | 20393241 |
| Dyslipidemias | Deregulated Nutrient Sensing | Serum cholesterol and LDL are independent risk factors for retinal hard exudates in type 2 diabetic north Indian patients who suffer from a remarkably high incidence of dyslipidemia. | 20393241 |
| ARCN1 gene, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | When compared with non-COPD patients, COPD patients were older and more likely to have diabetes, hypertension, and dyslipidemia. | 20394044 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance was found in 4% of patients, but no diabetes mellitus was detected in the 74 patients explored. | 20395666 |
| Hypertension, CTCAE, Haiti, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with MA had increased prevalence of hypertension (HT), insulin resistance and type 2 diabetes. | 20396921 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | [Prevalence of dyslipidemia and borderline dyslipidemia and other risk factors of coronary heart disease in residents from Beijing communities]. | 20398568 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | To investigate the prevalence of dyslipidemia and borderline dyslipidemia and other coronary heart disease (CHD) risk factors in residents from Beijing communities. | 20398568 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Incidence of dyslipidemia and borderline dyslipidemia was 31.23% and 23.30% respectively, 71.17% residents have at least 1 CHD major risk factor and 20.23% residents were in borderline CHD risks. | 20398568 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Over 1 out of 5 residents were in increased risk for borderline dyslipidemia or CHD risks. | 20398568 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Intensive control of dyslipidemia and CHD risk factors are warranted in Beijing residents. | 20398568 |
| Glucose Intolerance (disease), Hypertriglyceridemia | Deregulated Nutrient Sensing | Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia. | 20404017 |
| Cardiovascular Diseases, Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hypertriglyceridemia (HTG) is one of the key features of dyslipidemia in type 2 diabetes, caused by the overproduction and/or decreased clearance of triglyceride (TG)-rich lipoproteins, and significantly promotes the development of cardiovascular diseases in diabetes. | 20404017 |
| No Cardiac Valve Regurgitation, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Recent case reports suggest that benfluorex, a fenfluramine derivative used in the management of overweight diabetic patients and dyslipidemia, is associated with cardiac valve regurgitation. | 20405030 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Prevention of stroke includes modifying risk factors, like dyslipidemias. | 20405669 |
| Hyperlipidemia, Impaired T cell function | Deregulated Nutrient Sensing | Arecoline-induced fat cell dysfunction may lead to hyperlipidemia and hyperglycemia/insulin-resistance. | 20406654 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dietary carbohydrates have been associated with dyslipidemia, a lipid profile known to increase cardiovascular disease risk. | 20407058 |
| Cardiovascular morbidity, Hypertensive (finding), Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The NAGOYA HEART Study is a prospective randomized open-label blinded-endpoint study to compare an angiotensin II receptor blocker, valsartan, and a calcium channel blocker, amlodipine, regarding their efficacies on cardiovascular morbidity and mortality in Japanese hypertensive patients with glucose intolerance. | 20409690 |
| Dyslipidemias, Cardiovascular Diseases, Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, the 27-month community-based lifestyle modification of cardiovascular disease risks shows significant reductions in risks of diabetes, overweight and dyslipidemia in middle-aged Japanese. | 20410682 |
| Malocclusion | Deregulated Nutrient Sensing | However, we show that mice lacking at least one allele of both Sirt1 and Igfbp1 genes have a much higher incidence of malocclusion. | 20412791 |
| TG gene, Hypercholesterolemia | Deregulated Nutrient Sensing | Po-husk, apart from lowering LDL-C, also reduced TG, TG related to certain gene variants, TC, Apo B-100, oxLDL, insulin-resistance and systolic BP in mild-moderate hypercholesterolaemic individuals. | 20413122 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Relation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naive diabetes obese patients. | 20413173 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | The aim of the present study was to explore the relationship of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naive diabetic patients. | 20413173 |
| Carotid Atherosclerosis, Asthma, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Defined carotid atherosclerosis was diagnosed in 51 of the asthmatic patients, who were older, with a higher prevalence of males, a higher prevalence of dyslipidaemia and a lower mean daily dose of ICS than the 99 patients without carotid atherosclerosis. | 20413534 |
| Carotid Atherosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Stepwise multiple logistic regression analysis identified age, male sex and dyslipidaemia as positive risk factors for carotid atherosclerosis. | 20413534 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | 62% of patients reported comorbidities; systemic hypertension (35%), dyslipidaemia (13%), diabetes (12%) and coronary disease (11%) were the most frequent. | 20413540 |
| Hyperlipidemia, Obesity | Deregulated Nutrient Sensing | Additional genetic mutations and environmental factors, including insulin resistance and obesity, may contribute to the development of type III hyperlipidemia. | 20413671 |
| Endothelial dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Animal models of diabetes have shown that low plasma H(2)S levels are associated with marked endothelial dysfunction and insulin resistance. | 20414636 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | To determine the association between ASIC3 genetic polymorphisms and insulin resistance in Taiwanese, 606 unrelated subjects with no history of cardiovascular disease were recruited during routine health examinations. | 20416288 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance. | 20418489 |
| Dyslipidemias | Deregulated Nutrient Sensing | All the patients had dyslipidemia which reached normal levels after surgery. | 20419504 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | High-prevalence risk factors were dyslipidemia (83.1%), hypertension (39.3%), and overweight (42.2%) with pervasive clustering of these risks. | 20419873 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Being older was related to increased cardiovascular disease risk, except for dyslipidemia. | 20419873 |
| Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | A high percentage of persons being prescribed drug treatment for dyslipidemia and hypertension failed to reach authoritative targets for cardiovascular disease risk reduction. | 20419873 |
| Dyslipidemias, Paraplegia, Overweight, Hypertension, CTCAE | Deregulated Nutrient Sensing | Swedish persons with paraplegia are at high risk for dyslipidemia, hypertension, and overweight. | 20419873 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Pharmacotherapy for dyslipidemia and hypertension often failed to achieve recommended targets. | 20419873 |
| Proteinuria, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | A logistic regression analysis adjusted for age and gender showed that CAAC was significantly associated with age, hypertension, dyslipidemia, serum albumin, calcium-phosphorus product, proteinuria and CAP. | 20420796 |
| Alzheimers Disease", Impaired cognition, millicurie | Deregulated Nutrient Sensing | Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer's disease. | 20423560 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Chromium (Cr) supplementation improves glucose disposal in patients with insulin resistance and diabetes. | 20423560 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased serum ferritin concentrations in nonpathologic conditions, reflecting subclinical iron overload, have been reported to be associated with insulin resistance and an increased risk of type 2 diabetes mellitus (DM). | 20423745 |
| IFNG wt Allele, Metabolic Syndrome X | Deregulated Nutrient Sensing | Increased serum concentrations of ferritin are associated with insulin resistance, type 2 DM, IFG, and metabolic syndrome in men, but only with IFG in women. | 20423745 |
| bleomycin/cisplatin/vinblastine protocol, Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | As compared to controls, the frequency of hypertension, obesity, smoking, dyslipidemia, diabetes mellitus and a family history of stroke or CVD was increased significantly in VBD subjects. | 20424441 |
| Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | These results indicate that impairments in cognitive functioning associated with metabolic syndrome and type 2 diabetes may begin as early as middle age and are primarily due to insulin resistance. | 20424454 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | The total cholesterol, triglyceride (TG) or low density lipoprotein (LDL) levels more than 95th percentile for age and gender or high density lipoprotein (HDL) less then 35 mg/dL was defined as dyslipidemia. | 20427895 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The relative increase in hfPWV remained significant after adjustment for age, sex, hypertension, pulse rate, smoking, diabetes mellistus, dyslipidemia, and chronic kidney disease. | 20430390 |
| Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Studies have suggested that insulin resistance plays a role in cognitive impairment in individuals with type 2 diabetes. | 20435794 |
| millicurie, Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We aimed to determine whether an improvement in insulin resistance could explain cognitive performance variations over 36 weeks in older individuals with mild cognitive impairment (MCI) and type 2 diabetes. | 20435794 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Factors associated with psychological insulin resistance in individuals with type 2 diabetes. | 20435797 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes self-efficacy and better interaction with clinicians were important in decreasing patients' reluctance to use insulin, known as psychological insulin resistance. | 20435797 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 diabetes. | 20436182 |
| Obesity | Deregulated Nutrient Sensing | Upregulated cholesterol synthesis was associated with peripheral insulin resistance independent of obesity. | 20436182 |
| Demographics Domain, Obesity | Deregulated Nutrient Sensing | The precise mechanism by which obesity leads to insulin resistance and to DM is not completely described but it may be related to several biochemical factors, such as abnormalities in free fatty acids, adipokines, leptin and other substances (Tab. | 20437822 |
| Kidney Failure, Chronic, Dyslipidemias, Precocious atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia, a prominent feature of end-stage renal disease, is considered a risk factor for premature atherosclerosis in hemodialysis (HD) patients. | 20438514 |
| Renal function, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is related to loss of kidney function as well as use of low-flux cellulosic dialyzer membranes, but the effects of dialysate purity are unknown. | 20438514 |
| Triglycerides, Systemic Inflammatory Response Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Compared to baseline, treatment with conventional (mildly contaminated) dialysate significantly increased the uremic low-grade systemic inflammatory response syndrome (SIRS), augmented uremic dyslipidemia (triglycerides by +21%, and high-density lipoprotein (HDL) cholesterol by -10%) and enhanced oxidative stress. | 20438514 |
| Systemic Inflammatory Response Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | In contrast, the use of ultrapure dialysate significantly decreased uremia-associated SIRS, dyslipidemia (triglycerides -7% and HDL cholesterol +11%) and oxidative stress. | 20438514 |
| Dyslipidemias | Deregulated Nutrient Sensing | Ultrapure dialysis fluid improves potential parameters of cardiovascular risk by decreasing inflammatory reactions, improving uremic dyslipidemia and lowering oxidative stress. | 20438514 |
| Weight Gain | Deregulated Nutrient Sensing | However, high beverage energy and fructose intake may lead to weight gain and insulin resistance, respectively. | 20439553 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics. | 20444421 |
| Mitochondrial abnormalities | Deregulated Nutrient Sensing | We examined whether variation in PARL protein content is associated with mitochondrial abnormalities and insulin resistance. | 20444421 |
| Hyperglycemia | Deregulated Nutrient Sensing | This could be of importance for the metabolic aberrations associated to postsurgical complications, such as insulin resistance and hyperglycemia. | 20444921 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Salt sensitivity of blood pressure is strongly associated with insulin resistance in lean, essential hypertensive patients. | 20444953 |
| Dyslipidemias, Retinal Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia and hypertension in patients with type 2 diabetes and retinopathy. | 20446438 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is associated with dyslipidemia and higher cardiovascular risk and also generates multiple microvascular complications. | 20446438 |
| Dyslipidemias, Retinal Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Unspecified visual loss | Deregulated Nutrient Sensing | We found a statistically significant correlation between retinopathy and dyslipidemia, which suggested that the use of systemic lipid lowering therapy in type 2 diabetes is of benefit in patients with retinal changes, in order to prevent visual loss. | 20446438 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Presence of other risk factors (diabetes and dyslipidemia) was independently associated with higher hypertension rates. | 20448534 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, these results suggest that the increase in LDL cholesterol that occurred with the addition of P-OM3 to simvastatin therapy in subjects with mixed dyslipidemia was confined predominantly to those with low LDL cholesterol levels while receiving simvastatin monotherapy. | 20451686 |
| Lipodystrophy, Obesity | Deregulated Nutrient Sensing | Management of severe insulin resistance (IR) is a major clinical challenge in many patients with obesity or lipodystrophy, and also in rarer patients with proven or suspected genetic defects in the insulin receptor or downstream signalling. | 20455892 |
| Asthma, MS4A2 wt Allele, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. | 20456316 |
| Asthma, MS4A2 wt Allele, Obesity | Deregulated Nutrient Sensing | The roles of obesity and insulin resistance in asthma and atopy are not well understood. | 20456316 |
| Asthma, MS4A2 wt Allele, Obesity | Deregulated Nutrient Sensing | We investigated whether there is an association of obesity and insulin resistance with asthma and atopy prevalence in US adults. | 20456316 |
| MS4A2 wt Allele, Obesity | Deregulated Nutrient Sensing | Neither obesity measure nor insulin resistance was associated with atopy. | 20456316 |
| Asthma, Obesity | Deregulated Nutrient Sensing | Obesity was positively associated with asthma overall (odds ratio [OR] for obese vs normal BMI = 2.28, 95% CI: 1.76, 2.96; OR for obese vs normal waist circumference = 1.75; 95% CI: 1.22, 2.51) but insulin resistance was not (OR = 1.26; 95% CI: 0.80, 1.98). | 20456316 |
| Asthma, Obesity | Deregulated Nutrient Sensing | Obesity remained independently associated with all asthma outcomes after controlling for insulin resistance. | 20456316 |
| Asthma, Obesity, Atopy | Deregulated Nutrient Sensing | Obesity was independently associated with asthma, and atopic and nonatopic asthma, after controlling for insulin resistance and socio-demographic factors. | 20456316 |
| Asthma, MS4A2 wt Allele | Deregulated Nutrient Sensing | There was no evidence that insulin resistance was associated with atopy or asthma. | 20456316 |
| Liver carcinoma, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. | 20458764 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | To elucidate the role of insulin resistance (IR) and serum adiponectin level in hepatocellular carcinoma (HCC) associated with chronic hepatitis C. Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed HCC. | 20458764 |
| Hepatitis C, Diabetes Mellitus, FAM126A gene | Deregulated Nutrient Sensing | Insulin resistance measured by HOMA-IR, regardless of the presence of diabetes, is significantly associated with HCC development in patients with chronic HCV infection. | 20458764 |
| Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Weight loss in patients with type 2 diabetes can improve glycemic control, lower blood pressure, and improve dyslipidemia. | 20460445 |
| Lipolysis | Deregulated Nutrient Sensing | The positive correlation between subcutaneous adipose tissue AMPK and adiponectin or the evoked lipolysis rate could indicate a protective role of AMPK in this tissue, counteracting insulin resistance in morbid obese patients. | 20462511 |
| Obesity | Deregulated Nutrient Sensing | Adenine monophosphate (AMP) activated protein kinase (AMPK) is an important regulator of obesity. | 20462511 |
| Obesity | Deregulated Nutrient Sensing | Differences in AMPK expression between subcutaneous and visceral adipose tissue in morbid obesity. | 20462511 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | FINDRISC was the best single indicator of prevalent undiagnosed diabetes among all variables tested and strongly associated with insulin resistance. | 20463095 |
| Diabetes Mellitus, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Skin tags are dermatological lesions commonly found in the general population and have been associated with diabetes mellitus, obesity, insulin resistance and atherosclerosis. | 20464083 |
| Overweight, Obesity | Deregulated Nutrient Sensing | Patients with obesity or overweight, in comparison to those with normal BMI, showed insulin resistance and a higher concentration of high sensitivity C-reactive protein (hs-CRP), plasminogen activator inhibitor 1 (PAI-1), and interleukin 6 (Il-6). | 20464701 |
| Hyperlipidemia | Deregulated Nutrient Sensing | Exercise training is advocated in insulin resistance and statins are used to treat hyperlipidaemia, two cardiometabolic risk factors often presenting concurrently. | 20465545 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Many authors have suggested that insulin resistance could raise both incidence and mortality of coronary heart disease (CHD). | 20466373 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. | 20467002 |
| IFNG wt Allele | Deregulated Nutrient Sensing | Considering the role of caloric restriction in increasing the intestinal uptake of carnitine, the results suggest that oral L-carnitine administration, when associated with a hypocaloric feeding regimen, improves insulin resistance and may represent an adjunctive treatment for IFG and DM-2. | 20467011 |
| Dyslipidemias | Deregulated Nutrient Sensing | Efficacy of low dose atorvastatin in diabetic dyslipidaemia. | 20469785 |
| Atherosclerosis, Hyperglycemia, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Our study further confirms the importance of intensive examinations for the early detection of atherosclerosis and positive treatments for hypertension, dyslipidaemia, obesity, as well as hyperglycaemia are necessary when a reduced eGFR is found in diabetic patients. | 20470427 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is frequently associated with diabetes and cardiovascular disease. | 20470939 |
| Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Heart failure, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | No significant differences were found in age, sex, hypertension, dyslipidemia, smoking, diabetes mellitus, ischemic heart disease, heart failure, bronchopathy, or renal failure between groups. | 20472389 |
| Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Stroke survivors were more likely to be treated for hypertension (92.4% v 89.0%, P < .0001), diabetes (88.3% v 81.4%, P < .0001), and dyslipidemia (76.3% v 61.9%, P < .0001). | 20472464 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is also considered a hepatic manifestation of insulin resistance. | 20472517 |
| Sample Size Calculation, Dyslipidemias | Deregulated Nutrient Sensing | Patients with SSc exhibited mild dyslipidaemia expressed mainly by low serum levels of HDL-C and high TC (p < 0.001 and p < 0.021, respectively) compared to controls. | 20476856 |
| Microalbuminuria, Infarction | Deregulated Nutrient Sensing | Patients with microalbuminuria exhibit a larger infarct size as indicated by higher values of troponin I. Microalbuminuria was associated with higher values of glucose and a higher prevalence of insulin resistance. | 20479654 |
| Hyperglycemia, glucose metabolism | Deregulated Nutrient Sensing | Interestingly it was associated with acute glucose dysmetabolism (as inferred by hyperglycemia and the prevalence of insulin resistance), thus suggesting that it can be considered part of the acute metabolic response to the acute coronary event. | 20479654 |
| Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The goal of this study was to evaluate the effect of Roux-en-Y gastric bypass (RYGBP) on 2 metabolic disorders, diabetes and dyslipidemia, in obese type 2 diabetes mellitus (T2DM) patients. | 20485144 |
| Acute lymphocytic leukemia | Deregulated Nutrient Sensing | Impaired glucose tolerance and insulin resistance in survivors of childhood acute lymphoblastic leukemia: prevalence and risk factors. | 20485196 |
| Acute lymphocytic leukemia, Metabolic Syndrome X | Deregulated Nutrient Sensing | Survivors of acute lymphoblastic leukemia (ALL) are at increased risks of impaired glucose metabolism, insulin resistance, and metabolic syndrome. | 20485196 |
| FAM126A gene | Deregulated Nutrient Sensing | Furthermore, insulin resistance was significantly higher in the HCC patients than the healthy subjects (P=0.027). | 20486202 |
| FAM126A gene | Deregulated Nutrient Sensing | In addition, the significant correlations of serum IGF-1 levels with age and insulin resistance in the healthy subjects were not noted in the HCC patients. | 20486202 |
| Cessation of life | Deregulated Nutrient Sensing | These data suggest that the SIRT1-PARP-1 axis plays a critical role in the regulation of CS-induced autophagy and have important implications in understanding the mechanisms of CS-induced cell death and senescence. | 20493163 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Adjustments were made for age, smoking, type 2 diabetes mellitus, insulin resistance (HOMA-IR) and medication use. | 20494358 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Abdominal adiposity and low cardiorespiratory fitness are associated with insulin resistance in people with impaired glucose tolerance and type 2 diabetes. | 20495292 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, little is known about which factor precedes insulin resistance in people with impaired glucose tolerance and type 2 diabetes, and which is the stronger predictor of insulin resistance in non-diabetic people. | 20495292 |
| Dyslipidemias | Deregulated Nutrient Sensing | [Sporobakterin impact on atherogenic dyslipidemia at patients with intestinal dysbacteriosis]. | 20496791 |
| diabetic | Deregulated Nutrient Sensing | The preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HGF and insulin resistance in type 2 diabetic patients not receiving insulin treatment. | 20497462 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results of this preliminary study indicate that the presence of WML was associated with the high HGF and insulin resistance in Japanese patients with type 2 diabetes mellitus. | 20497462 |
| Obesity, Visceral, Dyslipidemias, Dysglycemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Visceral obesity is a central component but other major facets such as hypertension, dyslipidemia, or dysglycemia are often present. | 20497845 |
| Renal Insufficiency, Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The severity of renal histopathological findings in patients who underwent nephrectomy for resistant hypertension correlated with an increased prevalence of cardiovascular disease, a greater degree of renal dysfunction and more severe dyslipidaemia. | 20501460 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Given discrepancies between preclinical and clinical observations of mammalian target of rapamycin (mTOR) inhibition in prostate cancer, we sought to determine the pharmacodynamic effects of the mTOR/TORC1 inhibitor rapamycin in men with intermediate- to high-risk prostate cancer undergoing radical prostatectomy. | 20501622 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Elevated serum chemokine CXC ligand 5 levels are associated with hypercholesterolemia but not a worsening of insulin resistance in Chinese people. | 20501684 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The age-related increase in glucose intolerance may not be fully explained by the defect in HOMA-IR and HOMA-B. | 20503256 |
| Chronic heart failure | Deregulated Nutrient Sensing | The early origins of chronic heart failure: impaired placental growth and initiation of insulin resistance in childhood. | 20504866 |
| Heart failure | Deregulated Nutrient Sensing | The risk of heart failure was further increased by rapid gain in body mass index after the age of 2 years, a path of growth known to be linked to insulin resistance in later life. | 20504866 |
| Hypertension, CTCAE, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Fifty-six patients (42%) had central adiposity, 62 (46%) had hypertension, 46 (34%) had type 2 diabetes, seven (5%) had coronary artery disease, and 48 (36%) had dyslipidemia. | 20505515 |
| Macular edema due to diabetes mellitus, Dyslipidemias, Disorder of macula due to diabetes mellitus, Diabetes Mellitus | Deregulated Nutrient Sensing | Oral atorvastatin therapy in patients with diabetes mellitus and dyslipidemia seems to reduce the severity of hard exudates and fluorescein leakage in diabetic maculopathy and could be useful as an adjuvant therapy in the management of diabetic macular edema. | 20507015 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin resistance. | 20508082 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Type 2 DM is the commonest form of diabetes, which is characterized by insulin resistance. | 20509325 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Insulin resistance can be preceded by long term abnormality in glucose homeostasis which is called pre-diabetes. | 20509325 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | At baseline, 77.9% of patients were smokers, 45.2% had hypertension, 73.1% had dyslipidemia, 7.7% had diabetes, and 48.1% had a family history of CAD. | 20513067 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | [Association between the risk factors of cardiovascular diseases and insulin resistance]. | 20513276 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To explore the association between risk factors of cardiovascular diseases (CVD) and insulin resistance in a cross-sectional study. | 20513276 |
| TG gene, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | Sex (OR = 1.75), low HDL-C (OR = 1.80), hyperuricemia (OR = 2.11), high TG (OR = 2.14) and central obesity (OR = 2.68) appeared to be independently correlated to insulin resistance in multiple logistic regression analysis. | 20513276 |
| TG gene, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | The risk factors of CVD as low HDL-C, high TG, central obesity and hyperuricemia were independently correlated to insulin resistance. | 20513276 |
| Colorectal Neoplasms | Deregulated Nutrient Sensing | Our findings provide the first epidemiologic evidence for interactive effects of adiponectin and leptin in the early stage of colorectal tumorigenesis, distinct from their involvement in insulin resistance. | 20516125 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of serum lipoprotein ratios with insulin resistance in type 2 diabetes mellitus. | 20516535 |
| TG gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | TC/HDL-C ratio, TG/HDL-C, ratio, Non-HDL-C, WC, TG, and TC can be used as the markers of insulin resistance and CVD risk in T2D patients. | 20516535 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. | 20518948 |
| Hyperglycemia, Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | LEP I/G combined genotypes were not associated with hypertension, hyperglycemia, dyslipidemia and coronary artery disease. | 20520958 |
| Restenosis | Deregulated Nutrient Sensing | The degree of insulin resistance, FPG, RVD, SA, and SV were correlated with restenosis. | 20521015 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | PAD was strongly correlated with age and dyslipidemia in both sexes, carotid atherosclerosis in males, and abdominal fat in females. | 20523009 |
| Impaired cognition | Deregulated Nutrient Sensing | Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance. | 20524222 |
| Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine whether the cognitive impairments observed in adults with type 2 diabetes mellitus (T2DM) exist in preclinical disease, we compared 38 adult participants with evidence of insulin resistance (IR) to 54 age-, gender-, and education-matched control participants on a battery of neuropsychological tests. | 20524222 |
| Dyslipidemias, Overweight, GDC Comorbidity Terminology, Obesity | Deregulated Nutrient Sensing | BMI is linearly related to the total cholesterol, LDL cholesterol and triglyceride concentrations and is, however, inversely related with HDL cholesterol, Dyslipidaemia has been recognized to be strongly associated with overweight and obesity and its comorbid conditions. | 20524492 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia show an increasing trend with age in both male and female subjects. | 20524492 |
| Dyslipidemias | Deregulated Nutrient Sensing | In females, dyslipidaemia shows a gradual increase with age for all BMI categories. | 20524492 |
| Dyslipidemias | Deregulated Nutrient Sensing | There is increase in dyslipidaemia trend in our subjects with increase in BMI and age. | 20524492 |
| Chronic heart failure, Endothelial dysfunction | Deregulated Nutrient Sensing | Complement activation, endothelial dysfunction, insulin resistance and chronic heart failure. | 20524927 |
| Obesity, Abdominal, Cardiovascular Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Abdominal obesity is associated with type 2 diabetes, cardiovascular disease, dyslipidemia and hypertension. | 20525471 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Abdominal obesity is very frequently found in Danish primary care patients, and it is associated with an increased prevalence of diabetes, dyslipidemia and hypertension. | 20525471 |
| Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Studies have suggested a link between insulin resistance and mitochondrial dysfunction in skeletal muscles. | 20526759 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Fatty liver is known to be linked with insulin resistance, alcohol intake, diabetes and obesity. | 20529259 |
| Obesity | Deregulated Nutrient Sensing | As shown in the in vitro analysis, the low-grade proinflammatory environment and the insulin resistance associated with obesity may contribute to downregulate LPIN1 in adipose tissue, leading to a worse metabolic profile. | 20530740 |
| Liver damage | Deregulated Nutrient Sensing | To improve her insulin resistance, we administered pioglitazone therapy for 1 week; however, subsequent laboratory findings did not indicate any improvement in her liver damage. | 20530928 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Gestational diabetes mellitus is defined as glucose intolerance that first occurs or is first identified during pregnancy. | 20530932 |
| Hypercholesterolemia, Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Rosuvastatin, a statin indicated for patients with primary hypercholesterolemia, mixed dyslipidemia and familial hypercholesterolemia, is well tolerated by most patients. | 20531065 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Student forum: Does calcium and vitamin D intake affect incidence of type 2 diabetes mellitus and insulin resistance syndrome? | 20534409 |
| Increased insulin level, Obesity, Abdominal, Dyslipidemias, Heart Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperinsulinemia, hypertension, abdominal obesity, dyslipidemia, and coagulation abnormalities-which contribute to insulin resistance syndrome-are major risk factors for T2DM and heart disease. | 20534409 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | As our population ages, the risk of diabetes and insulin resistance will rise, so the question is whether calcium and vitamin D (D3, cholecalciferol) supplementation is necessary or is warranted at a greater or lesser degree than the current recommendations. | 20534409 |
| Weight decreased | Deregulated Nutrient Sensing | Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. | 20534751 |
| Weight decreased | Deregulated Nutrient Sensing | Weight loss of 10% after low-calorie diet increased 25OHD levels, and this increase was mainly associated with improvement of insulin resistance. | 20534751 |
| Obesity | Deregulated Nutrient Sensing | Elevated plasma procalcitonin levels in the normal range are associated with measures of obesity, insulin resistance, and MS in the general population. | 20534760 |
| Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Compared with the lowest quartile of SUA, prevalence of abdominal obesity, hypertension, and dyslipidemia was significantly increased in the highest quartile in boys and that of abdominal obesity was increased in the highest quartile in girls. | 20534946 |
| Glucose Intolerance (disease), Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | The consequences for live kidney donors with preexisting glucose intolerance without diabetic complication: analysis at a single Japanese center. | 20535851 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | In CHC, insulin resistance is independently associated with the presence of genotypes 1/4. | 20536721 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We tested the hypothesis that an elevated level of HSCRP correlates with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes mellitus. | 20537668 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results indicate that the elevated level of HSCRP in Japanese nondementia patients with type 2 diabetes mellitus is characterized by increased hippocampus volume and insulin resistance, and that the z score and HOMA index are independent predictors of HSCRP. | 20537668 |
| diabetic | Deregulated Nutrient Sensing | Clinical effectiveness and safety evaluation of long-term pioglitazone treatment for erythropoietin responsiveness and insulin resistance in type 2 diabetic patients on hemodialysis. | 20540652 |
| Anemia | Deregulated Nutrient Sensing | We determined the efficacy of pioglitazone by monitoring anemia, glycemic control, insulin resistance, and levels of inflammatory cytokines and high-molecular-weight (HMW) adiponectin for 96 weeks. | 20540652 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | While the C/A ratio provided little advantage to predict MetS, it might be more useful to predict insulin resistance than CRP or HMW adiponectin alone. | 20543521 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | History of myocardial infarction and medication for dyslipidaemia, hypertension, and diabetes mellitus were also recorded. | 20544162 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalences of diabetes mellitus (5.9%), dyslipidaemia (11.1%), and hypertension (14.1%) were also significantly higher in the paraplegic group, as were drug treatment for these disorders. | 20544162 |
| Dyslipidemias, Paraplegia, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Persons with paraplegia report increased prevalences of diabetes mellitus, hypertension, and dyslipidaemia, in particular, compared with the general population. | 20544162 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Relationship between plasma uridine and insulin resistance in patients with non-insulin-dependent diabetes mellitus. | 20544544 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Furthermore, it was recently reported that plasma uridine is correlated with homeostasis model assessment of insulin resistance (HOMA-R) in hypertensive patients. | 20544544 |
| NEUROD1 wt Allele | Deregulated Nutrient Sensing | We found a positive relationship between plasma uridine value and HOMA-R, serum insulin, and CPR, suggesting that plasma uridine is a marker of insulin resistance in patients with NIDDM. | 20544544 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The main risk factors were hypertension (60.5%), dyslipidemia (42.9%), smoking (45.1%) and diabetes (23.9%, of whom 13.2% were on insulin therapy). | 20545251 |
| Demographics Domain | Deregulated Nutrient Sensing | To identify the relationship between insulin resistance and sympathetic activity, we examined muscle sympathetic nerve activity (MSNA) in controlled type 2 DM patients with alpha-glucosidase inhibitor (GI). | 20547473 |
| Glucose Intolerance (disease), Blood Glucose | Deregulated Nutrient Sensing | Black persons have higher HbA(1c) levels than white persons across the full spectrum of glycemia, and the differences increase as glucose intolerance worsens. | 20547905 |
| Liver carcinoma, Metabolic Syndrome X, FAM126A gene | Deregulated Nutrient Sensing | Metabolic syndrome and insulin resistance have been linked to increased risk of occurrence and mortality of hepatocellular carcinoma (HCC). | 20549233 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, relevant patients with atherogenic dyslipidemia represented less than 17 percent of the ACCORD Lipid population (941 out of 5518 patients). | 20550659 |
| Dyslipidemias | Deregulated Nutrient Sensing | Among all other 4548 patients without atherogenic dyslipidemia such rates were 10.1% in both fenofibrate and placebo study groups. | 20550659 |
| Dyslipidemias | Deregulated Nutrient Sensing | Therefore, an important finding of ACCORD Lipid study was the observation that fibrates may lead to cardiovascular risk reduction in patients with atherogenic dyslipidemia not only as monotherapy but in combination with statins as well. | 20550659 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, in patients with atherogenic dyslipidemia (high triglycerides and low HDL-C, fibrates -- either as monotherapy or combined with statins - were associated with reduced risk of cardiovascular events. | 20550659 |
| Glycogen storage disease type II | Deregulated Nutrient Sensing | Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease. | 20554235 |
| Sarcopenia, Atherosclerosis | Deregulated Nutrient Sensing | Many predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which is another leading cause of morbidity and mortality in elderly subjects. | 20554280 |
| Hypertension, CTCAE, Obesity, Prehypertension | Deregulated Nutrient Sensing | Obesity, abnormalities of glucose metabolism and insulin resistance were the major factors associated with prehypertension and hypertension. | 20555358 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Impact on dyslipidemia of the laparoscopic ileal interposition associated to sleeve gastrectomy in type 2 diabetic patients. | 20556664 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is known to increase significantly the odds of major cardiovascular events in the general population. | 20556664 |
| Dyslipidemias | Deregulated Nutrient Sensing | The objective of the study was to evaluate the control of dyslipidemia in patients with T2DM and BMI below 30 that were submitted to the laparoscopic ileal interposition associated to sleeve gastrectomy. | 20556664 |
| Dyslipidemias | Deregulated Nutrient Sensing | The laparoscopic ileal interposition associated to sleeve gastrectomy was an effective operation for the regression of dyslipidemia and T2DM in a non-obese population. | 20556664 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | This type of dyslipidaemia frequently appears in patients with chronic kidney disease (CKD). | 20562093 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia. | 20562628 |
| Dyslipidemias | Deregulated Nutrient Sensing | Whether these concentrations are prospectively associated with an adverse lipid profile and an increased risk of incident dyslipidemia has not yet been investigated. | 20562628 |
| Dyslipidemias | Deregulated Nutrient Sensing | Low total testosterone concentrations are prospectively associated with an adverse lipid profile and increased risk of incident dyslipidemia. | 20562628 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Treatment with atypical antipsychotic agents is often complicated by dyslipidemia, which is a risk factor for cardiovascular disease. | 20562674 |
| TG gene | Deregulated Nutrient Sensing | Although the association between BMI and both HDL and TG may be explained by insulin resistance, the lack of a significant association between BMI and LDL remains an unexpected finding that requires further investigation. | 20563664 |
| Diabetes Mellitus, Non-Insulin-Dependent, square decimeter | Deregulated Nutrient Sensing | A single-nucleotide polymorphism in D2 (Thr92Ala) has been associated with increased insulin resistance in nondiabetic and type 2 diabetes (DM2) subjects. | 20566590 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | The negative impact of diabetes mellitus is well recognized, yet little is known about the effect of this disease on the liver, an organ susceptible to nonalcoholic fatty liver disease related to insulin resistance. | 20566726 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Compared two studies,the exposed rates of hypertension, abdominal obesity, dyslipidemia were increased from 26.82%, 26.39%, 20.45% to 29.82%, 46.1%, 44.20%. | 20568459 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia and cardiovascular disease: a series of epidemiologic studies in Japanese populations. | 20571251 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | Furthermore, even when analysis is restricted to ischemic stroke, the relationship between dyslipidemia and stroke is very weak. | 20571251 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Accordingly, it is difficult to perform cohort studies of dyslipidemia and cardiovascular disease. | 20571251 |
| Glucose Intolerance (disease), Obesity, Abdominal | Deregulated Nutrient Sensing | Forty men with abdominal obesity and glucose intolerance were randomized in a prospective, 12-month double-blind trial to receive either GH or placebo. | 20572419 |
| metabolic disturbance | Deregulated Nutrient Sensing | Insulin resistance (IR) and related metabolic disturbances are characterized by low levels of adiponectin. | 20573249 |
| Glucose Intolerance (disease), Pancreatitis, Chronic | Deregulated Nutrient Sensing | Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis. | 20573586 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In the CP groups, significant differences (increasing with the degree of glucose intolerance) in glucagon responses during the first hour of OGTT compared to IVGTT were observed (CP+NGT: -13 + or - 22 vs. -88 + or - 17, p = 0.02; CP+IGT: 3 + or - 17 vs. -87 + or - 19, p = 0.01; CP+DM: 94 + or - 27 vs. -78 + or - 16 1 h x pmol/l (mean + or - SEM), p<0.001). | 20573586 |
| Prediabetes syndrome, Atherosclerosis | Deregulated Nutrient Sensing | A1C between 5.7 and 6.4% as a marker for identifying pre-diabetes, insulin sensitivity and secretion, and cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study (IRAS). | 20573754 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Single determinations of FPG and 2-h plasma glucose seem to be more precise correlates of insulin resistance and secretion than A1C and, in general, better for other metabolic disorders. | 20573754 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemias and physicochemical changes in low-density lipoprotein (LDL) are very important factors for the development of coronary artery disease (CAD). | 20574778 |
| Ischemia | Deregulated Nutrient Sensing | Insulin resistance (IR) results in higher FFA concentrations and impaired myocardial glucose use, potentially worsening ischemia. | 20576156 |
| Prediabetes syndrome, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The association between prediabetes as currently defined and incident diabetes in populations with widespread obesity, insulin resistance syndrome, and diabetes is not well defined. | 20578203 |
| Albuminuria, Obesity | Deregulated Nutrient Sensing | Measures of obesity, A(1c), FPG, 2-h PG, FI, albuminuria, and insulin resistance (IR) help predict this conversion. | 20578203 |
| Dyslipidemias | Deregulated Nutrient Sensing | Secondary prevention in the form of early detection of dyslipidemia and risk modification via drug and non-drug procedures, particularly among the high-risk group, is thus imperative. | 20578501 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Type 2 diabetes mellitus is associated with dyslipidemia and with an increased risk of coronary heart disease (CHD). | 20580029 |
| Inflammation | Deregulated Nutrient Sensing | Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. | 20581149 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Biochemical tests revealed hyperglycemia and dyslipidemia on the next day. | 20584318 |
| Diabetes, Autoimmune | Deregulated Nutrient Sensing | [Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]. | 20584648 |
| Diabetes, Autoimmune | Deregulated Nutrient Sensing | To investigate the relation between insulin resistance and glutamic acid decarboxylase antibody (GAD-Ab) titers in latent autoimmune diabetes in adults (LADA). | 20584648 |
| Overgrowth | Deregulated Nutrient Sensing | In LGA pre-pubertal children the severity of intrauterine overgrowth was associated with the insulin resistance indices. | 20585203 |
| HIV-1 Infection Pathway, Acute infectious disease | Deregulated Nutrient Sensing | Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner. | 20585398 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | The ENSANUT 2006 data confirm that the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high. | 20585729 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Correlation between the Indexes of Insulin Resistance and Renal Function in the Presence of Hypertension. | 20588057 |
| Hypertension, CTCAE, Haiti | Deregulated Nutrient Sensing | There have been no reports on the relationship between insulin resistance and renal function in the presence of hypertension (HT). | 20588057 |
| Haiti | Deregulated Nutrient Sensing | A clearer correlation between HOMA-IR and eGFR was observed in the non-HT group than the HT group, suggesting that HT may attenuate the direct correlation between the insulin resistance and renal function indices. | 20588057 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Adiposity contributes to the insulin resistance and endothelial dysfunction of the hypertensive state; the inflammatory network and the metalloprotease (MMP)/ tissue inhibitor of metalloprotease (TIMP) system modulate vascular structure and function. | 20589975 |
| HIV, HIV-Associated Lipodystrophy Syndrome, HIV Infections | Deregulated Nutrient Sensing | The introduction of highly active antiretroviral therapy (HAART) has dramatically changed the prognosis of human immunodeficiency virus (HIV) infection, with a significant decline in morbidity and mortality.Changes in body fat distribution are a common finding in individuals with HIV infection being treated with antiretrovirals, and this condition (collectively termed lipodystrophy syndrome) is associated with depletion of subcutaneous fat, increased triglycerides and insulin resistance. | 20591174 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | High-dose vitamin D(3) improved systolic blood pressure and B-type natriuretic peptide levels, but not endothelial function, insulin resistance or glycosylated haemoglobin in patients with type 2 diabetes. | 20596692 |
| Dyslipidemias, Obesity, Bipolar Disorder | Deregulated Nutrient Sensing | Obesity and dyslipidemia were particularly prevalent in patients with bipolar disorder. | 20599461 |
| Atherosclerosis | Deregulated Nutrient Sensing | However, the effects of SIRT1 loss-of-function on the endothelium in atherosclerosis remain to be characterized. | 20606253 |
| atherosclerotic | Deregulated Nutrient Sensing | We observed no difference in endothelial relaxation and eNOS (Ser1177) phosphorylation between 20-week old male atherosclerotic ApoE-/- SIRT1+/- and ApoE-/- SIRT1+/+ mice. | 20606253 |
| Sleep Apnea, Obstructive, Snoring, Osage language | Deregulated Nutrient Sensing | Obstructive sleep apnea (OSA) and snoring are known independent risk factors for insulin resistance. | 20607426 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. | 20615436 |
| Steatohepatitis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | This condition is characterized by severe dyslipidemia, insulin resistance, diabetes mellitus, and steatohepatitis. | 20616664 |
| Cardiomyopathies | Deregulated Nutrient Sensing | Extreme insulin resistance and the possibility of a "lipotoxic cardiomyopathy" should be entertained as possible explanations. | 20616664 |
| Myocardial Ischemia, Cerebrovascular accident | Deregulated Nutrient Sensing | This may represent a potential biological explanation to the beneficial effects of ACE-inhibition on stroke, ischemic heart disease and insulin resistance. | 20617288 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Residual dyslipidaemia in patients treated with statins needs to be addressed to reduce the prevalence of cardiovascular disease in primary and secondary care. | 20619240 |
| Dyslipidemias, Meibomian gland dysfunction | Deregulated Nutrient Sensing | Association of dyslipidemia in moderate to severe meibomian gland dysfunction. | 20619393 |
| Dry Eye Syndromes, Dyslipidemias, Meibomian gland dysfunction | Deregulated Nutrient Sensing | To determine whether meibomian gland disease, a major contributor to dry eye syndrome, is associated with dyslipidemia. | 20619393 |
| Dyslipidemias | Deregulated Nutrient Sensing | main outcome measure: The prevalence of dyslipidemia (elevated total cholesterol, elevated LDL, decreased HDL, or elevated triglycerides) in patients with moderate to severe MGD. | 20619393 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with moderate to severe MGD had a higher incidence of dyslipidemia with respect to elevated total cholesterol (>200 mg/dL), 67.4% to 45.1% (P = .0012) when compared to population controls. | 20619393 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with moderate to severe MGD have a higher incidence of dyslipidemia with respect to elevated total cholesterol than the general population. | 20619393 |
| Metabolic Diseases | Deregulated Nutrient Sensing | This study further supports a role for SELS in the development of metabolic disease, especially in the context of insulin resistance. | 20619427 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Randomized, open-label cross-over study investigating the effect of fenofibrate (160 mg), atorvastatin (10 mg), and combination of both in patients with type 2 diabetes mellitus and atherogenic dyslipidemia. | 20619837 |
| Obesity, therapeutic hemodilution | Deregulated Nutrient Sensing | Studies suggest lowering the threshold of the prostate specific antigen test in obese men due to the hemodilution effect but prostate specific antigen may be affected by prostate volume and insulin resistance, which also increase with obesity. | 20620404 |
| Dyslipidemias, Diabetes Mellitus, Heart failure, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Eligibility and claims data (2002-2004) were used to identify beneficiaries with dyslipidemia, hypertension, coronary artery disease (CAD), heart failure, or diabetes. | 20621868 |
| Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The proportion of patients without a prescription fill for recommended medications varied by disease (43% hypertension, 40% dyslipidemia and CAD, and 25% diabetes and heart failure). | 20621868 |
| Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Medication nonadherence was high (69% hypertension, 64% CAD, 57% heart failure, 48% dyslipidemia, 41% diabetes). | 20621868 |
| Diabetes Mellitus, NEUROD1 wt Allele | Deregulated Nutrient Sensing | Identification of insulin resistance (IR) in the general population is important for developing strategies to reduce the prevalence of non-insulin-dependent diabetes mellitus (NIDDM). | 20622341 |
| Abnormality, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of MS manifestations among Arab children is extremely high, with dyslipidemia being the most common MS abnormality. | 20624169 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Treatment with metformin to improve insulin resistance and address the diabetes proved successful. | 20625965 |
| glycation | Deregulated Nutrient Sensing | Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects. | 20626403 |
| Inflammation | Deregulated Nutrient Sensing | Since oxidative stress and inflammation impair insulin actions as well, it is conceivable that AGEs may play some role in insulin resistance. | 20626403 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | Age and male sex but not hypertension or dyslipidemia were predictors of presence of obstructive coronary artery disease (Duke score >or=2). | 20626669 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | [Serum omega-3 polyunsaturated fatty acid and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease]. | 20627036 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate the relationship between serum omega-3 polyunsaturated fatty acid (omega-3PUFA) and insulin resistance (IR) in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease (NAFLD). | 20627036 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Of these patients, 8 (67%) had diabetes, 8 (67%) had coronary artery disease and 10 (83%) had dyslipidaemia. | 20627865 |
| Obesity | Deregulated Nutrient Sensing | G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity. | 20627936 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance is associated with the pathogenesis of metabolic disorders as type 2 diabetes and obesity. | 20627936 |
| Tumor necrosis | Deregulated Nutrient Sensing | We analyzed the influence of GRK2 levels in insulin signaling in myoblasts and adipocytes with experimentally increased or silenced levels of GRK2, as well as in GRK2 hemizygous animals expressing 50% lower levels of this kinase in three different models of insulin resistance: tumor necrosis factor-a (TNF-a) infusion, aging, and high-fat diet (HFD). | 20627936 |
| diabetic | Deregulated Nutrient Sensing | Intraoperative insulin resistance is associated with an increased risk of complications, independent of the patient's diabetic state. | 20631016 |
| Weight decreased | Deregulated Nutrient Sensing | Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss. | 20631025 |
| Weight decreased, Obesity | Deregulated Nutrient Sensing | Differences in PEDF observed after weight loss were related to changes in obesity, insulin resistance, and blood pressure measures. | 20631025 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Criteria for obesity, hypertension, dyslipidemia and hyperglycemia were primarily those of World Health Organization (WHO) and the International Diabetes Federation. | 20634032 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Chromium supplementation does not appear to ameliorate insulin resistance or impaired glucose metabolism in patients at risk for type 2 diabetes and thus is unlikely to attenuate diabetes risk. | 20634174 |
| Malignant tumor of colon, Primary malignant neoplasm, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia. | 20634278 |
| Dyslipidemias | Deregulated Nutrient Sensing | There was no significant association between increased CAWT and dyslipidemia or smoking. | 20634310 |
| Burn Specimen Source Codes | Deregulated Nutrient Sensing | Insulin resistance secondary to the hypermetabolic stress response persists in severely burned children when burn wounds are at least 95% healed. | 20634704 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Atorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia. | 20637495 |
| Pre-Eclampsia | Deregulated Nutrient Sensing | Meanwhile, the results of our study suggest that insulin resistance and other cardiovascular risk factors are related to microvascular reactivity in middle-aged women with a history of preeclampsia. | 20637782 |
| Obesity | Deregulated Nutrient Sensing | PAI-1 and t-PA correlated with lipid parameters, markers of insulin resistance, blood pressure and obesity. | 20640487 |
| Dyslipidemias | Deregulated Nutrient Sensing | Non-LDL-related dyslipidaemia and coronary risk: a case-control study. | 20643700 |
| vascular inflammations, Endothelial dysfunction | Deregulated Nutrient Sensing | Resveratrol (RV)-induced SirT1 activation also improves endothelial dysfunction and suppresses vascular inflammation. | 20644332 |
| atherosclerotic | Deregulated Nutrient Sensing | SirT1 expression was decreased in aged and atherosclerotic vessels in vivo, and significantly reduced in endothelial cells purified from vessel tissues. | 20644332 |
| atherosclerotic | Deregulated Nutrient Sensing | Our data suggested that SirT1 could be a crucial factor involved in the endothelial cells of atherosclerotic CAGB patients and aging rats. | 20644332 |
| Cardiovascular Diseases, Hypertriglyceridemia, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Diabetic dyslipidaemia, characterized by hypertriglyceridaemia as a result of elevated serum very-low-density lipoprotein (VLDL) concentrations, contributes to the increased risk of cardiovascular disease (CVD) in type 2 diabetes (T2DM). | 20649626 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Preoperative comorbidities were dyslipidemia in 52.3%, insulin resistance in 30.7%, arterial hypertension in 24.6%, and type 2 diabetes in 5.5%. | 20652325 |
| nervous system disorder, Cardiovascular Diseases | Deregulated Nutrient Sensing | Mg deficiency is associated with insulin resistance, cardiovascular disease, and disorders of the nervous system. | 20653401 |
| Inflammation, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) often have inflammation and dyslipidemia that accelerate to atherosclerosis. | 20654604 |
| Dyslipidemias | Deregulated Nutrient Sensing | More attention should be paid to dyslipidemia in the management of the CAPD patients. | 20654604 |
| Overweight, Obesity | Deregulated Nutrient Sensing | Overweight, obesity, and their associations with insulin resistance and b-cell function among Chinese: a cross-sectional study in China. | 20655552 |
| Sensorineural Hearing Loss (disorder), Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Idiopathic sudden sensorineural hearing loss: evolution in the presence of hypertension, diabetes mellitus and dyslipidemias. | 20658017 |
| Dyslipidemias, Systolic dysfunction, Obesity | Deregulated Nutrient Sensing | The multivariate analysis for independent predictors of primary end points showed that age (P = .001), gender (P = .02), dyslipidemia (P = .01), obesity (P = .001), and systolic dysfunction (P = .048) represented the significant predictors. | 20659788 |
| Dyslipidemias | Deregulated Nutrient Sensing | Older age, increased adiposity, and dyslipidemia were the dominant features of FHD(+) clinical phenotype. | 20660046 |
| Non-alcoholic Fatty Liver Disease, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The analysis shows that type II diabetes (DM) and/or insulin resistance (IR) are independent predictors of overall mortality in CH-B, NAFLD and ALD (p <0.05). | 20660697 |
| Fatty Liver, No metabolic abnormalities, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Most of these patients have metabolic abnormalities such as obesity, dyslipidemia and fatty liver. | 20660985 |
| Fatty Liver, Dyslipidemias | Deregulated Nutrient Sensing | She showed a slight body fat increase, dyslipidemia and fatty liver. | 20660985 |
| Chronic Lymphocytic Leukemia | Deregulated Nutrient Sensing | Here, we have analyzed the mechanisms involved in AICAR-induced apoptosis in CLL cells in which it activates its only well-known molecular target, adenosine monophosphate-activated protein kinase (AMPK). | 20664053 |
| Chronic Lymphocytic Leukemia | Deregulated Nutrient Sensing | AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. | 20664053 |
| Cessation of life, Chronic Lymphocytic Leukemia | Deregulated Nutrient Sensing | However, AMPK activation with phenformin or A-769662 failed to induce apoptosis in CLL cells and AICAR also potently induced apoptosis in B lymphocytes from Ampka1(-/-) mice, demonstrating an AMPK-independent mechanism of cell death. | 20664053 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Two of the eight patients had diabetes and one had pre-existing dyslipidaemia. | 20664584 |
| Obesity | Deregulated Nutrient Sensing | Asian Indians as an ethnic group are at particularly high risk of insulin resistance and central obesity. | 20666703 |
| Obesity | Deregulated Nutrient Sensing | There were no statistically significant associations with obesity, metabolic parameters, insulin resistance or any inflammatory cytokines identified. | 20668471 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes and insulin resistance in the absence of high BP did not seem to contribute significantly to UAE in this cohort. | 20668471 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These findings suggested that insulin resistance and exaggerated glucose fluctuation could be attributable to poor outcomes after AMI in patients with new diabetes. | 20674993 |
| Glucose Intolerance (disease), Overweight, Obesity | Deregulated Nutrient Sensing | However, there was no significant difference in the age-standardised prevalence of glucose intolerance, overweight or obesity. | 20675005 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Atherogenic dyslipidemia in patients with established coronary artery disease. | 20675108 |
| Dyslipidemias, Data types - Address, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Patients with stable coronary heart disease (CHD) and atherogenic dyslipidemia (AD) have a high-risk of recurrence and are those who derive most benefit from treatment with lipid-lowering agents. | 20675108 |
| Dyslipidemias | Deregulated Nutrient Sensing | Laboratory alterations such as dyslipidemia and increase of hepatic enzymes are reported. | 20676466 |
| Prediabetes syndrome, Overweight, Dyslipidemias, Prehypertension | Deregulated Nutrient Sensing | We found a high prevalence of smoking (18.9%), arterial prehypertension (14.1%) and overweight (11.2%), 9.2% of study participants had prediabetes, and the most frequent dyslipidemia was low HDL cholesterol (13.3%). | 20676535 |
| Obesity | Deregulated Nutrient Sensing | High total fat and SFA intake and a low intake of MUFAs and omega-3 PUFAs showed imbalanced nutrition, which could be responsible for the increasing prevalence of obesity and insulin resistance in urban Asian Indian adolescents and young adults. | 20679142 |
| Obesity | Deregulated Nutrient Sensing | Studies in obesity have implicated adipocytokines in the development of insulin resistance, which in turn may lead to accelerated aging. | 20679357 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In this study, we determined associations of chromosomal telomere length (TL) to markers of obesity and insulin resistance in middle-aged adult male and female Arabs with and without diabetes mellitus type 2 (DMT2). | 20679357 |
| Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are associated with chromosomal TL among adult Arabs. | 20679357 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia causes coronary heart disease in middle-aged and elderly adults, but the consequences of lipid exposure during young adulthood are unclear. | 20679558 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Intensive behavioral treatment was provided, patients with dyslipidemia and diabetes were excluded, and attrition at 2 years was high. | 20679559 |
| Metabolic Diseases, Dyslipidemias, Endothelial dysfunction, Glycogen Storage Disease | Deregulated Nutrient Sensing | The glycogen storage diseases are a rare form of inherited metabolic disease affecting intracellular glycogen metabolism, and several studies suggest glycogen storage disease (GSD) III predisposes patients to dyslipidemia and endothelial dysfunction. | 20679683 |
| Inflammation, Endothelial dysfunction | Deregulated Nutrient Sensing | Biomarkers of inflammation, endothelial dysfunction and insulin resistance in adults of Inner Mongolia, China. | 20680929 |
| Inflammation, Endothelial dysfunction | Deregulated Nutrient Sensing | Low-grade chronic inflammation and endothelial dysfunction have been hypothesized to underlie the constellation of cardiometabolic risk factors, possibly by inducing insulin resistance. | 20680929 |
| Inflammation, Endothelial dysfunction | Deregulated Nutrient Sensing | This study suggests that inflammation and endothelial dysfunction may relate to insulin resistance. | 20680929 |
| Inflammation, Sarcopenia, Malnutrition, Chronic disease | Deregulated Nutrient Sensing | The causes of sarcopenia are multi-factorial and can include disuse, changing hormonal function, chronic diseases, inflammation, insulin resistance, and nutritional deficiencies. | 20683658 |
| Hepatobiliary Disorder, Metabolic Syndrome X | Deregulated Nutrient Sensing | Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease. | 20683957 |
| Prostate Cancer Outcomes Study, Hyperandrogenism | Deregulated Nutrient Sensing | Women with PCOS had higher insulin resistance and hyperandrogenism indices and lower flow-mediated dilation compared with controls. | 20684955 |
| Prostate Cancer Outcomes Study, Hyperandrogenism | Deregulated Nutrient Sensing | Both insulin sensitizers induced favorable changes in insulin resistance and hyperandrogenism indices in women with PCOS. | 20684955 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In young women with PCOS, treatment with metformin or pioglitazone for 6 months induces a similar beneficial effect on endothelial function; this may be partially attributed to an improvement in insulin resistance. | 20684955 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Two received antihypertensive medications, two had type 2 diabetes and four were treated for dyslipidaemia. | 20685833 |
| Infertility, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Increased cardiovascular risk factors (obesity and dyslipidaemia) and infertility are important sequelae and active identification and treatment are necessary. | 20685833 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Low-dose metformin improves pregnancy rate in in vitro fertilization repeaters without polycystic ovary syndrome: prediction of effectiveness by multiple parameters related to insulin resistance. | 20687400 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Low-dose metformin improved pregnancy rate in IVF repeaters without PCOS, probably by decreasing insulin resistance. | 20687400 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Controlling SIRT1 expression by microRNAs in health and metabolic disease. | 20689156 |
| Metabolic Diseases | Deregulated Nutrient Sensing | The FXR/miR-34a pathway and other miRs controlling SIRT1 may be useful therapeutic targets for age-related diseases, including metabolic disorders. | 20689156 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | On average 54% of residents with documented CVD were prescribed aspirin and 31% of those with CVD and/or dyslipidaemia were prescribed statins. | 20690381 |
| atherosclerotic, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | A TRIB3 Q84R gain-of-function polymorphism has been associated with insulin resistance both in vitro and in vivo and with several atherosclerotic phenotypes, including increased carotid intima-media thickness (IMT). | 20693163 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. | 20698957 |
| Obesity, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%. | 20698957 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | High prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population. | 20698957 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Coronary heart disease | Deregulated Nutrient Sensing | A randomized trial with 325 patients referred to the centre between 1988 and 1989 for dyslipidemia, hypertension, type 2 diabetes and coronary heart disease; 239 patients were randomized to the programme, 86 randomized to usual care. | 20700054 |
| Dyslipidemias, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus | Deregulated Nutrient Sensing | Among the 710 patients with personal history of cardiovascular disease (CVD) and/or diabetes, 632 (89%) presented with dyslipidaemia, of which 278 (44%) and 134 (21%) patients were treated and adequately controlled, respectively. | 20700055 |
| Infarction, Dyslipidemias | Deregulated Nutrient Sensing | Further investigation revealed dyslipidemia, impaired glucose tolerance, and a middle cerebral artery territory infarct. | 20702115 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individuals. | 20702522 |
| Obesity | Deregulated Nutrient Sensing | Our results demonstrate that insulin resistance and oxidative stress have a significant impact on the CFU-EC colony formation in obesity. | 20706205 |
| Glucose Intolerance (disease), Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of obesity, elevated plasma triglyceride, and glucose intolerance was higher among older subjects and subjects both of whose parents had diabetes. | 20707738 |
| Obesity | Deregulated Nutrient Sensing | Markers of cholesterol synthesis cluster with clinical and laboratory markers of obesity and insulin resistance. | 20708389 |
| Alcoholic Intoxication, Chronic, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The various listed risk factors were: dyslipidemia (58.1%), obesity (36.12%), alcoholism (16.7%) and diabetes (10.6%). | 20708726 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diseases of mitral valve | Deregulated Nutrient Sensing | Effects of chronic elevation of atrial natriuretic peptide and free fatty acid levels in the induction of type 2 diabetes mellitus and insulin resistance in patients with mitral valve disease. | 20709514 |
| Diseases of mitral valve | Deregulated Nutrient Sensing | The relationship between atrial natriuretic peptide (ANP), increased free fatty acid (FFA) and insulin resistance in patients with mitral valve disease (MVD), a group characterised by elevated atrial pressure and increased ANP levels, is not defined. | 20709514 |
| Tumor necrosis, Hyperinsulinism, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | In CHD, insulin resistance and hyperinsulinaemia were present both before and after surgery with increased tumour necrosis factor (TNF)-a and interleukin (IL)-6 levels. | 20709514 |
| Increased insulin level, Pancreatic carcinoma | Deregulated Nutrient Sensing | Several reports have suggested that conditions associated with hyperinsulinemia and insulin resistance, such as diets high in carbohydrates, may influence the risk of pancreatic cancer, although results from prior studies have been mixed. | 20711806 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for incident type 2 diabetes; however, no study has specifically assessed the lipid ratios (i.e. | 20712907 |
| TG gene | Deregulated Nutrient Sensing | Screening programs that could identify insulin resistance early enough for intervention to affect outcome often rely on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels. | 20715971 |
| selenium | Deregulated Nutrient Sensing | For men, AUC-ROC for prediction of insulin resistance by TG/HDL-C was: 0.77 +- 0.01, mean +- standard error (SE), with an optimal cutoff of >=2.5. | 20715971 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results strongly support the hypothesis that saturated fatty acids are associated with insulin resistance and glucose intolerance and that saturated fatty acids are significant risk factors for type 2 diabetes. | 20719107 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Recent studies have demonstrated a relationship between insulin resistance (IR) and type 2 diabetes mellitus (T2DM). | 20720269 |
| Ischemic stroke, Thrombophilia | Deregulated Nutrient Sensing | The relationship between insulin resistance and hypercoagulability in acute ischemic stroke. | 20720426 |
| Infarction | Deregulated Nutrient Sensing | Insulin resistance has effects on the coagulation system, which is important in the acute phase of infarct. | 20720426 |
| Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | We examined the relationships between insulin resistance, hemostatic markers and stroke severity in acute ischemic stroke patients. | 20720426 |
| Ischemic stroke | Deregulated Nutrient Sensing | Protein C (PC), protein S (PS), fibrinogen, von Willebrand factor and antithrombin III (AT III) were studied in 75 acute ischemic stroke patients with and without insulin resistance. | 20720426 |
| Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | The significant associations between insulin resistance and hemostatic markers may be relevant to stroke severity by causing a procoagulant tendency in acute ischemic stroke. | 20720426 |
| Hyperglycemia, physiopathological | Deregulated Nutrient Sensing | Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction. | 20724579 |
| Increased insulin level | Deregulated Nutrient Sensing | We hypothesized that murine Pparg-P465L mutation leads to covert insulin resistance, which is masked by hyperinsulinemia and increased pancreatic islet mass, to retain normal plasma glucose. | 20724579 |
| Hyperglycemia | Deregulated Nutrient Sensing | PPARg-P465L mutation worsens hyperglycemia in Ins2(Akita/+) mice primarily because of adipose-specific insulin resistance and altered storage function. | 20724579 |
| Inflammation, Adrenal Gland Hyperfunction, Cardiovascular Diseases | Deregulated Nutrient Sensing | The frailty syndrome is associated with inflammation, hypercortisolemia, and cardiovascular diseases, all of which are linked with insulin resistance. | 20725120 |
| Weight decreased | Deregulated Nutrient Sensing | Our results suggest that postprandial insulin resistance is higher in frail than in healthy elderly women, and TEF is similar, indicating that both processes do not contribute to the propensity for body weight loss. | 20725120 |
| Apolipoproteins B, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Overall, 36% of patients had normal LDL cholesterol values but elevated apolipoprotein B. Apolipoprotein B is the most frequently occurring dyslipidaemia in type 2 diabetes. | 20726197 |
| Apolipoproteins B, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To analyze the pattern of dyslipidaemias including apolipoprotein B in type 2 diabetes. | 20726197 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis. | 20728234 |
| Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin resistance, increased leptin, and decreased adiponectin serum levels. | 20728234 |
| Cessation of life, Liver Cirrhosis, FAM126A gene | Deregulated Nutrient Sensing | In patients with compensated HCV cirrhosis, insulin resistance but not serum levels of adiponectin and leptin predicted the occurrence of HCC and of liver-related death or transplantation. | 20728234 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | The main preoperative comorbidities were: systemic arterial hypertension (79%), dyslipidemia (48%) and family history of coronary artery disease (38%). | 20730262 |
| Obesity | Deregulated Nutrient Sensing | IGF-binding protein 2 (IGFBP2) is secreted by white adipocytes and contributes to the prevention of diet-induced obesity and age-related insulin resistance in mice. | 20730703 |
| Obesity | Deregulated Nutrient Sensing | The present study was aimed at determining IGFBP2 mRNA levels in adipose tissue in conditions of insulin resistance such as aging and obesity. | 20730703 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was associated with CAD in males and family history of CAD was a significant risk factor for females with positive CTA findings. | 20734235 |
| Dyslipidemias, Chronic Kidney Diseases, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease. | 20736985 |
| Proteinuria, Dyslipidemias | Deregulated Nutrient Sensing | Lower GFR was associated with higher triglycerides, lower HDL-C, and higher non-HDL-C. Nephrotic-range proteinuria was significantly associated with dyslipidemia and combined dyslipidemia. | 20736985 |
| Dyslipidemias | Deregulated Nutrient Sensing | Compared with children with a GFR>50, children with a GFR<30 had significantly increased odds ratios for any dyslipidemia or for combined dyslipidemia. | 20736985 |
| Nephrotic range proteinuria, Dyslipidemias, Chronic Kidney Diseases, Obesity | Deregulated Nutrient Sensing | Hence, among children with moderate chronic kidney disease, dyslipidemia is common and is associated with lower GFR, nephrotic proteinuria, and non-renal factors including age and obesity. | 20736985 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Dyslipidemias constitute an independent risk factor for the development of atherogenesis and they also predispose to the development of endothelial dysfunction (ED). | 20737263 |
| Obesity | Deregulated Nutrient Sensing | Relating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period. | 20738279 |
| Obesity | Deregulated Nutrient Sensing | Increasing insulin resistance was associated with a shorter time to FMP (P < 0.003) and associations of obesity and time to FMP were observed (P = 0.004, in model with FSH). | 20738279 |
| Steatohepatitis, Metabolic Diseases, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Liver steatosis is often found in association with common cardiometabolic disorders, conditions that may all occur in a shared context of abdominal obesity and dyslipidemia. | 20738844 |
| Hypermetabolism, Malignant neoplasm of gastrointestinal tract | Deregulated Nutrient Sensing | The metabolic response to gastrointestinal cancer in patients undergoing surgery is associated with hypermetabolism and insulin resistance. | 20739147 |
| Obesity, diabetic | Deregulated Nutrient Sensing | Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients. | 20739208 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | However, it may be that resistin plays a role in the pathogenesis of obesity and insulin resistance, both of which could, indirectly, contribute to the development of type 2 diabetes. | 20739208 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama study. | 20739649 |
| Increased insulin level, Hyperglycemia | Deregulated Nutrient Sensing | The results of this study suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate NP formation in combination with the effects of APOE epsilon4. | 20739649 |
| Thyroid dysfunction | Deregulated Nutrient Sensing | Associations between cardiovascular risk, insulin resistance, beta-cell function and thyroid dysfunction: a cross-sectional study in She ethnic minority group of Fujian Province in China. | 20798227 |
| Thyroid dysfunction | Deregulated Nutrient Sensing | To investigate the associations between cardiovascular risk, insulin resistance (IR), b-cell function and thyroid dysfunction in She ethnic minority group in China. | 20798227 |
| Inflammation, Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Obesity | Deregulated Nutrient Sensing | Excess secretion of various adipocyte-derived molecules has been linked with insulin resistance, obesity, diabetes, inflammation, atherosclerosis, and cardiovascular disease. | 20798476 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidaemia (62% vs. 56%; p <0.001), history of CAD (39% vs. 35%; p = 0.023) and obesity (BMI >30 kg/m2 [23% vs. 19%; p = 0.003]) were more frequent in group 1 who were admitted longer after symptom onset (280 min vs. 230 min). | 20799102 |
| Hypoglycemia | Deregulated Nutrient Sensing | Insulin antibody (IAb) may be produced in patients receiving long-term, animal-derived insulin, leading to insulin resistance or hypoglycemia. | 20799766 |
| Critical Illness | Deregulated Nutrient Sensing | Impact of glucocorticoids on insulin resistance in the critically ill. Glucocorticoids (GCs) have been shown to reduce insulin sensitivity in healthy individuals. | 20801543 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | N-3 fatty acids have several beneficial effects on dyslipidemia and diabetes, conditions which are prevalent in the elderly. | 20803425 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Disposition index, glucose effectiveness, and conversion to type 2 diabetes: the Insulin Resistance Atherosclerosis Study (IRAS). | 20805282 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In a cross-sectional study we studied the fasting serum DPP-4 enzymatic activity (sDPP-4) and the insulin resistance index (HOMA2-IR) in gliptin naive patients with type 2 diabetes and in non-alcoholic fatty liver disease (NAFLD) and in healthy controls (CNTRL). | 20805868 |
| Weight Gain, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Treatment with antipsychotics can be associated with weight gain, and second-generation (atypical) antipsychotics (SGAs) can increase the risk for diabetes and dyslipidemia. | 20807065 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. | 20807870 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Dysglycemia was associated with hypertension, dyslipidemia, and older age. | 20808110 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. | 20808308 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | AMP-activated protein kinase activation is cytotoxic to cancer cells, supporting AMPK as a tumour suppressor and a potential therapeutic target. | 20808308 |
| Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Among 718 colon and rectal cancers, phosphorylated AMPK (p-AMPK) and p-MAPK3/1 expression was detected in 409 and 202 tumours, respectively, by immunohistochemistry. | 20808308 |
| Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Phosphorylated AMPK expression in colorectal cancer is associated with superior prognosis among p-MAPK3/1-positive cases, but not among p-MAPK3/1-negative cases, suggesting a possible interaction between the AMPK and MAPK pathways influencing tumour behaviour. | 20808308 |
| Hyperglycemia, Dyslipidemias, ETV3 wt Allele | Deregulated Nutrient Sensing | Our findings emphasize the importance of MetS screening and managing dyslipidemia and hyperglycemia in older persons in general practice. | 20810578 |
| Hepatitis C, Depression, CTCAE | Deregulated Nutrient Sensing | In addition to literature data on KYN/TRY ratio (IDO activity index), we observe neopterin levels (index of activity of rate-limiting enzyme of guanine-BH4 pathway) to be higher in carriers of high (T) than of low (A) producers alleles; and to correlate with AAMPD markers (e.g., insulin resistance, body mass index, mortality risk), and with IFN-alpha-induced depression in hepatitis C patients. | 20811799 |
| SLC25A20 gene, Dyslipidemias | Deregulated Nutrient Sensing | In contrast, CAC showed much weaker associations with smoking and dyslipidemia and a strong male predominance. | 20814018 |
| Obesity | Deregulated Nutrient Sensing | Individuals with insulin resistance (IR) usually have upper body obesity phenotype, often accompanied by an increase in plasma free fatty acids (FFA). | 20815161 |
| Non-insulin Hypoglycemic | Deregulated Nutrient Sensing | Eighteen individuals presented insulin resistance (HOMA-IR > 2.7) and 29 were non-insulin resistant (non-IR). | 20815161 |
| Dyslipidemias | Deregulated Nutrient Sensing | This effect increased after adjustment for gender, serum creatinine and known dyslipidaemia (OR27.61; 95% CI 6.41-119.04). | 20815655 |
| Dyslipidemias | Deregulated Nutrient Sensing | To determine the prevalence of and risk factors for dyslipidemia in Shanghai. | 20817022 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia increased with age, with the peak prevalence (43%) occurring after age 55. | 20817022 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | There is a high prevalence of dyslipidemia, mainly hypertriglyceridemia and low HDL-C, in Shanghai. | 20817022 |
| Inflammation, Periodontal Diseases, Atherosclerosis | Deregulated Nutrient Sensing | The candidates contributing to atherosclerosis in periodontal disease include low-grade inflammation such as C-reactive protein (CRP) and insulin resistance. | 20817211 |
| Inflammation, Periodontal Diseases | Deregulated Nutrient Sensing | A previous study demonstrated that periodontal therapy leads to an improvement in CRP as well as insulin resistance, indicating the relationship between periodontal disease and low-grade inflammation or insulin resistance. | 20817211 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidaemia is a major risk factor for coronary heart disease. | 20817685 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, insulin resistance was less severe in elderly-onset diabetes than in usual-onset diabetes. | 20819452 |
| Atrial Fibrillation by ECG Finding, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident | Deregulated Nutrient Sensing | Patients with atrial fibrillation, previous myocardial infarction, diabetes mellitus, dyslipidemia, tobacco use, and no or irregular use of anti-platelet medications were at higher risk for recurrent stroke. | 20819503 |
| Malnutrition, Dyslipidemias, Cerebrovascular accident, Heart failure, Comorbidity | Deregulated Nutrient Sensing | Patients who did not survive were significantly older, with lower cognitive and functional performance, with diminished visual acuity, higher comorbidity, high risk of malnutrition, higher number of drugs taken and a higher percentage of patients with the diagnosis of dyslipidaemia, heart failure or previous stroke. | 20823123 |
| diabetic | Deregulated Nutrient Sensing | Effects of telmisartan on insulin resistance in Japanese type 2 diabetic patients. | 20823643 |
| diabetic | Deregulated Nutrient Sensing | PPARgamma agonists are widely used in type 2 diabetic patients to reduce insulin resistance. | 20823643 |
| Structure of beta Cell of islet | Deregulated Nutrient Sensing | In addition to improving insulin resistance and pancreatic b-cell dysfunction, the GLP-1 agonists and DPP-4 inhibitors improve the impaired incretin response, as well as increase insulin secretion and reduce glucagon secretion, both in a glucose-dependent manner. | 20824239 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Our objective was to elucidate the specific roles of obesity, type 2 diabetes mellitus, insulin-resistance and abdominal fat distribution. | 20825466 |
| Ndonga language | Deregulated Nutrient Sensing | DO and NDO subjects had similar whole-body insulin resistance, BMI and waist circumference, higher than those of C subjects (P < 0*001). | 20825466 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Type 2 diabetes is associated with increased fat accumulation in the liver, independent of obesity and whole-body insulin resistance. | 20825466 |
| Hyperglycemia, Critical Illness | Deregulated Nutrient Sensing | Hyperglycemia and insulin resistance frequently occur in critically ill and in morbidly obese (MO) patients. | 20825686 |
| Critical Illness | Deregulated Nutrient Sensing | As in MO patients, increased levels of proinflammatory cytokines and altered levels of adipokines may contribute to the development of insulin resistance in critically ill patients. | 20825686 |
| Chronic heart failure | Deregulated Nutrient Sensing | Addition of losartan to angiotensin-converting enzyme inhibitors improves insulin resistance in patients with chronic heart failure treated without b-blockers. | 20827028 |
| Chronic heart failure, Congestive heart failure | Deregulated Nutrient Sensing | Angiotensin II and insulin resistance (IR) have clinical implications in the pathophysiology of chronic heart failure (CHF). | 20827028 |
| Obesity | Deregulated Nutrient Sensing | Serum resistin concentrations are higher in human obesity but independent from insulin resistance. | 20827661 |
| Obesity | Deregulated Nutrient Sensing | The b(2)-adrenergic receptor (ADRB2) mediates obesity, cardiorespiratory fitness, and insulin resistance. | 20829805 |
| Dyslipidemias | Deregulated Nutrient Sensing | Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias. | 20831628 |
| Dyslipidemias | Deregulated Nutrient Sensing | Previous studies have suggested a link between circulating levels of 25-hydroxyvitamin D (25-D) and dyslipidaemias. | 20831628 |
| Overweight | Deregulated Nutrient Sensing | Multiple regression analysis showed that serum osteocalcin levels were associated with VFA in obese and overweight men after adjustment for age, insulin resistance, current smoking, alcohol consumption and adiposity indices. | 20831864 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. | 20837822 |
| palladium, "Alzheimers Disease", Data types - Address, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a causal factor in prediabetes (PD) and type 2 diabetes (T2D) and increases the risk of developing Alzheimer disease (AD). | 20837822 |
| Impaired cognition, Data types - Address | Deregulated Nutrient Sensing | Insulin resistance may be a marker of AD risk that is associated with reduced CMRglu and subtle cognitive impairments at the earliest stage of disease, even before the onset of mild cognitive impairment. | 20837822 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The significant genes were tested in a logistic regression model controlling for age, hypertension, and dyslipidemia. | 20837969 |
| Glucose Intolerance (disease), Complication Aspects | Deregulated Nutrient Sensing | Concomitant preservation of pancreaticoduodenal complex eliminated risks of biliary complications and glucose intolerance. | 20844978 |
| Alzheimers Disease", Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Aerobic exercise improves cognition for older adults with glucose intolerance, a risk factor for Alzheimer's disease. | 20847403 |
| Acanthosis Nigricans, Steatohepatitis | Deregulated Nutrient Sensing | Normal-weight 14-year-old girl with acanthosis nigricans and markedly increased hepatic steatosis: evidence for the important role of ectopic fat deposition in the pathogenesis of insulin resistance in childhood and adolescence. | 20847546 |
| Obesity | Deregulated Nutrient Sensing | A major factor in the development of insulin resistance is obesity. | 20847546 |
| Acanthosis Nigricans, Steatohepatitis | Deregulated Nutrient Sensing | This case presentation of a normal-weight girl with acanthosis nigricans and markedly increased hepatic steatosis provides support for the association between intrahepatic fat deposition and insulin resistance in adolescence. | 20847546 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The CLU gene was associated with diabetes, probably through an increase in insulin resistance primarily and through an impairment of insulin secretion secondarily. | 20850846 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Optimal pharmacologic approach to patients with hypertriglyceridemia and low high-density lipoprotein-cholesterol: randomized comparison of fenofibrate 160 mg and niacin 1500 mg. Atherogenic dyslipidemia is emerging as a target of lipid-modifying therapy. | 20855072 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our results underscore more individualized pharmacologic approaches to patients with atherogenic dyslipidemia. | 20855072 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Data were adjusted for BMI, insulin resistance, and duration of diabetes. | 20855551 |
| Peripheral Vascular Diseases, Dyslipidemias, Heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | The development of an episode of IC was independently associated with diabetes, dyslipidemia, presence of heart failure, peripheral arterial disease and treatment with digoxin or ASA. | 20857527 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased very-low-density lipoprotein triglycerides (VLDL-TG) concentration is a central feature of diabetic dyslipidemia. | 20858686 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | [Effects of bushen tongmai recipe on expression of phosphatidylinositol-3-kinase in PCOS rats accompanying with insulin resistance]. | 20862969 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | To observe the effects of bushen tongmai recipe (BSTMR) on mRNA and protein expressions of phosphatidylinositol-3-kinase (PI-3K) p85alpha in hepatic, adipose, muscular and ovarian tissues in PCOS rats with insulin resistance (IR). | 20862969 |
| Endoribonuclease ZC3H12A | Deregulated Nutrient Sensing | A significant difference (p < 0.05) between the 2 groups was found in the treatment-induced changes in fasting insulin, the insulin resistance index HOMA, HDL cholesterol, triglycerides, diastolic blood pressure (all in favor of pioglitazone) and in body weight (increase with pioglitazone). | 20863381 |
| Heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Heart failure (HF) is associated with increased insulin resistance, but the consequences of HF for development of diabetes are not well studied. | 20864482 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia of mothers with familial hypercholesterolemia deteriorates lipids in adult offspring. | 20864670 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, Hypopituitarism | Deregulated Nutrient Sensing | Because metabolic syndrome, including insulin resistance, is the main pathogenesis of the development of nonalcoholic fatty liver disease (NAFLD), we considered that patients diagnosed with hypopituitarism have an increased risk of developing NAFLD. | 20865648 |
| Critical Illness, Obesity | Deregulated Nutrient Sensing | Adiponectin has been proposed as an important regulator of glucose metabolism influencing obesity and insulin resistance, which are important risk factors for the outcome of critically ill patients. | 20869198 |
| Non-alcoholic Fatty Liver Disease, Obesity, Fatty infiltration | Deregulated Nutrient Sensing | Obesity and insulin resistance cause fatty infiltration of many organs, including the pancreas (pancreatic steatosis [PS]) and the liver (nonalcoholic fatty liver disease [NAFLD]). | 20871475 |
| Inflammation, Critical Illness, Hyperglycemia | Deregulated Nutrient Sensing | We investigated the potential role of leptin components in critically ill patients, because systemic inflammation, insulin resistance, and hyperglycemia are common features of critical illness. | 20871818 |
| Seizures, Dyslipidemias, Cerebral Hemorrhage | Deregulated Nutrient Sensing | The associated factors of post-stroke seizures were non-dyslipidemia (p = 0.0007), intracerebral hemorrhage (p = 0.015), and lesions at cortical area (p = 0.05). | 20873075 |
| Carcinogenesis, Mass in breast | Deregulated Nutrient Sensing | Insulin resistance and breast carcinogenesis: a cross-sectional study among Iranian women with breast mass. | 20874423 |
| Breast Carcinoma, Carcinogenesis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Despite existing epidemiologic data concerning the increased incidence of breast cancer in diabetes type 2, the association between insulin resistance and breast carcinogenesis is not yet well defined. | 20874423 |
| Carcinogenesis, Breast Carcinoma | Deregulated Nutrient Sensing | We conclude that the noted linkage between insulin resistance and breast cancer may indicate an underlying pathology of mammary carcinogenesis. | 20874423 |
| Atrial Fibrillation by ECG Finding, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Peripheral Vascular Diseases, Carotid Stenosis, Hypertension, CTCAE | Deregulated Nutrient Sensing | Characteristics associated with in-hospital mortality were age, arrival mode (eg, via ambulance versus other mode), history of atrial fibrillation, previous stroke, previous myocardial infarction, carotid stenosis, diabetes mellitus, peripheral vascular disease, hypertension, history of dyslipidemia, current smoking, and weekend or night admission. | 20876438 |
| glucose metabolism | Deregulated Nutrient Sensing | The significant correlation between GGT and acute glucose dysmetabolism (as indicated by admission glycemia and insulin-resistance) can account, at least in part, for the prognostic role of GGT. | 20878500 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Early onset type 2 diabetes mellitus (T2DM) is associated with obesity, insulin resistance and impaired beta-cell function. | 20880682 |
| Non-alcoholic Fatty Liver Disease, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | NAFLD was present in 41% of our obese children and was associated with higher insulin resistance, but not with impaired beta-cell function. | 20880682 |
| Hypertension, CTCAE, Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | Telmisartan effects on insulin resistance in obese or overweight adults without diabetes or hypertension. | 20883237 |
| Cardiovascular morbidity, Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Patients with dyslipidemia and advanced renal failure are at markedly increased risk of cardiovascular morbidity and mortality. | 20885068 |
| Overweight | Deregulated Nutrient Sensing | Insulin resistance and self-perceived scholastic competence in inner-city, overweight and obese, African American children. | 20887741 |
| Congestive heart failure | Deregulated Nutrient Sensing | Testosterone supplementation improves functional capacity, insulin resistance, and muscle strength in women with advanced CHF. | 20888520 |
| Inflammation, Disease, Atherosclerosis | Deregulated Nutrient Sensing | Fatty acid-binding proteins (FABPs) 4 and 5 play coordinated roles in rodent models of inflammation, insulin resistance, and atherosclerosis, but little is known of their role in human disease. | 20920650 |
| Postoperative Complications, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | NAFLD and insulin resistance do not increase the risk of postoperative complications among patients undergoing bariatric surgery--a prospective analysis. | 20922498 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) and insulin resistance are common consequences of obesity and are highly prevalent among patients undergoing bariatric surgery. | 20922498 |
| Postoperative Complications, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and NAFLD have been reported to be associated with postoperative complications following major surgery. | 20922498 |
| Inflammation, Chronic pain, Obesity | Deregulated Nutrient Sensing | After adjustment for insulin resistance, inflammation, and pain-related comorbidities, central obesity predicted higher TPI scores (OR 1.55, 95% CI 1.04-2.33) and nearly doubled the risk of chronic pain (OR 1.70, 95% CI 1.05-2.75). | 20926190 |
| Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Non-khat chewers were more likely to have diabetes mellitus, hypertension, dyslipidemia, obesity, and prior history of coronary artery disease and revascularization. | 20926835 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum levels of retinol-binding protein 4 (RBP4) are associated with insulin resistance and type 2 diabetes mellitus (T2DM) and may impact on b-cell function. | 20929509 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | D2 Thr92Ala and PPARg2 Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients. | 20930717 |
| Sepsis, Hyperglycemia | Deregulated Nutrient Sensing | Hyperglycemia and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis. | 20932285 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes. | 20932285 |
| Liver function | Deregulated Nutrient Sensing | The strong associations with hepatic and renal function, insulin resistance and acute mortality collectively suggest a role of RBP4 in the pathogenesis of critical illness, possibly as a negative acute phase reactant, and allow a proposition as a potential novel biomarker for ICU patients. | 20932285 |
| Dyslipidemias | Deregulated Nutrient Sensing | Recent evidence has also suggested that a calcium-rich diet may have beneficial effects on insulin resistance and dyslipidemia. | 20934855 |
| Tumor necrosis, Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Association of osteopontin and tumor necrosis factor-a levels with insulin resistance in obese patients with obstructive sleep apnea syndrome. | 20935448 |
| Ischemic stroke | Deregulated Nutrient Sensing | Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study. | 20937946 |
| Ischemic stroke | Deregulated Nutrient Sensing | Whether insulin resistance predicts ischemic stroke (IS) is still a matter of debate. | 20937946 |
| Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the association between insulin resistance (IR) and risk of first ischemic stroke in a large, multiethnic, stroke-free cohort without diabetes. | 20937946 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance estimated using the HOMA is a marker of increased risk of incident stroke in nondiabetic individuals. | 20937946 |
| Fatty Liver, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polymorphisms in the gene encoding adiponectin receptor 1 (AdipoR1) are associated with insulin resistance, fatty liver, increased risk for type 2 diabetes and cardiovascular disease. | 20938443 |
| Structure of posterior cerebral artery | Deregulated Nutrient Sensing | However, the oncogenic contributions downstream of the PI3K pathway made by mammalian target of rapamycin complex 1 (mTORC1)-mediated cell growth signal transduction in PCa have yet to be elucidated in detail. | 20940396 |
| Tuberous Sclerosis | Deregulated Nutrient Sensing | Here, we engineered constitutive mTORC1 activation in prostate epithelium by a conditional genetic deletion of tuberous sclerosis complex 1 (Tsc1), a potent negative regulator of mTORC1 signaling. | 20940396 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia is high and increases even in younger people. | 20942934 |
| Dyslipidemias, Abnormal | Deregulated Nutrient Sensing | Patients with short duration of dyslipidemia were mainly characterized by relatively young age, occupational groups, not eating or irregular eating breakfast, less physical activities, having the habit of smoking, and 53.8% is with abnormal LDL-c, 10.4% is with abnormal HDL-c, and 51.5% is with abnormal TG. | 20942934 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is highly prevalent in Asian Indians and contributes to worldwide public health problems, including diabetes and related disorders. | 20943755 |
| Cardiac Death | Deregulated Nutrient Sensing | Stepwise Cox hazard analysis associated cardiac death with reduced BMIPP uptake and increased insulin resistance. | 20944544 |
| Cardiac Death, Coronary Artery Disease | Deregulated Nutrient Sensing | Thus, impaired myocardial fatty acid metabolism and insulin resistance may be associated with cardiac death among hemodialysis patients without obstructive coronary artery disease. | 20944544 |
| Dyslipidemias | Deregulated Nutrient Sensing | The occurrence of dyslipidemia is increasing in pediatric populations. | 20944894 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | The majority of the population was dyslipidemic (63.8%; 95%CI: 59.3 - 68.2), with hypoalphalipoproteinemia being the most prevalent dyslipidemia (56%; 95%CI: 51.3 - 60.5). | 20944894 |
| Inflammation, Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | The mechanisms by which OSAS can affect the cardiovascular system are multiple, including the activation of the sympathetic nervous system, systemic inflammation, insulin resistance, and oxidative stress. | 20944980 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance and vitamin D deficiency in patients with chronic kidney disease stage 2-3. | 20945958 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. | 20945958 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease. | 20945958 |
| AHSG protein, human, Vascular calcification | Deregulated Nutrient Sensing | Fetuin-A has been associated with insulin resistance and inversely related with vascular calcification. | 20946008 |
| Atherosclerosis | Deregulated Nutrient Sensing | Serum fetuin-A concentration was not associated with measures of insulin resistance or with preclinical atherosclerosis in Hispanics and NHW. | 20946008 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | These data indicate that the disparity in prevalence of insulin resistance, type 2 diabetes, and subclinical atherosclerosis between Hispanics and NHW does not appear attributable to differences in fetuin-A concentrations. | 20946008 |
| Cavia | Deregulated Nutrient Sensing | Reduced oxidative stress and improved insulin resistance may contribute to the improvement of CAVI by glimerpiride. | 20946343 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | Impaired glucose tolerance, insulin resistance, dyslipidemia, and microalbuminuria are common among young adults with HIV. | 20947103 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Other advantages are the low frequency of flushing, which improved adherence to treatment, and no worsening of insulin resistance in patients with or without diabetes mellitus. | 20948500 |
| Dyslipidemias | Deregulated Nutrient Sensing | Effects of low-dose of niacin associated to simvastatin in the treatment of mixed dyslipidemia Salgad. | 20948500 |
| Dyslipidemias, Coronary heart disease, Diabetes Mellitus, Anemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Arterial hypertension (48.6%), anemia (22.9%), coronary disease (19.4%), dyslipidemia (17.3%) and diabetes (16.6%) were the main risk factors. | 20949226 |
| Congenital Abnormality | Deregulated Nutrient Sensing | Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study. | 20950415 |
| Left ventricular diastolic dysfunction, Heart failure, Diabetic Cardiomyopathies, Diabetes Mellitus, Non-Insulin-Dependent, Bortezomib/Dexamethasone/Pegylated Liposomal Doxorubicin Regimen | Deregulated Nutrient Sensing | Left ventricular diastolic dysfunction (LVDD) is considered a precursor of diabetic cardiomyopathy, while insulin resistance (IR) is a precursor of type 2 diabetes mellitus (T2DM) and independently predicts heart failure (HF). | 20950415 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Resistin is an adipocytokine involved in insulin resistance, inflammation, and atherosclerosis. | 20951381 |
| diabetic | Deregulated Nutrient Sensing | Serum profiles of lipids and/or liver enzymes are established markers for the estimation of insulin resistance and diabetic risk in the non-diabetic middle-aged population. | 20953067 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Patients with mixed dyslipidemia characterized by elevated low-density lipoprotein cholesterol (LDL-C), elevated triglycerides (TG), and reduced high-density lipoprotein cholesterol (HDL-C) often require combination therapy to improve multiple lipid and nonlipid parameters. | 20953684 |
| Kidney Failure | Deregulated Nutrient Sensing | Habitual coffee users have risk protection to higher RRI; lower serum albumin, insulin resistance, and renal insufficiency are associated with greater RRI. | 20954972 |
| Erectile dysfunction | Deregulated Nutrient Sensing | * BMI was a significant predictor of decreased libido, impotence and a PAS-SFI score <9, while diabetes/glucose intolerance was a significant predictor of sexual inactivity, impotence and a PAS-SFI score <9. | 20955266 |
| Sexual Dysfunction, Charge Type Reason - Intolerance | Deregulated Nutrient Sensing | * Age, IPSS, BMI and diabetes/glucose intolerance, but not serum testosterone or TPV, were significant independent predictors of sexual dysfunction in the REDUCE study population. | 20955266 |
| Weight decreased | Deregulated Nutrient Sensing | Duration of the follow-up and extent of weight loss were similar among the three groups, as were fasting and glucose-stimulated insulin and indices of insulin resistance. | 20956435 |
| Alzheimers Disease", Tauopathies | Deregulated Nutrient Sensing | AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. | 20957377 |
| Supranuclear paralysis, "Alzheimers Disease", Corticobasal degeneration, Data types - Address, Parkinsonian Disorders, Tauopathies, Brain Diseases, cannabidiol, Frontotemporal dementia | Deregulated Nutrient Sensing | Here, we show that activated AMPK (p-AMPK) is abnormally accumulated in cerebral neurons in 3R+4R and 3R tauopathies, such as Alzheimer's disease (AD), tangle-predominant dementia, Guam Parkinson dementia complex, Pick's disease, and frontotemporal dementia with parkinsonism linked to chromosome 17, and to a lesser extent in some neuronal and glial populations in the 4R tauopathies, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease. | 20957377 |
| Data types - Address | Deregulated Nutrient Sensing | In AD brains, p-AMPK accumulation decorated neuropil threads and dystrophic neurites surrounding amyloid plaques, and appeared in more than 90% of neurons bearing pre-tangles and tangles. | 20957377 |
| Tauopathies | Deregulated Nutrient Sensing | Granular p-AMPK immunoreactivity was also observed in several tauopathies in apparently unaffected neurons devoid of tau inclusion, suggesting that AMPK activation preceded tau accumulation. | 20957377 |
| Tauopathies | Deregulated Nutrient Sensing | Thus, activated AMPK abnormally accumulated in tangle- and pre-tangle-bearing neurons in all major tauopathies. | 20957377 |
| Tauopathies, Nerve Degeneration | Deregulated Nutrient Sensing | By controlling tau phosphorylation, AMPK might regulate neurodegeneration and therefore could represent a novel common determinant in tauopathies. | 20957377 |
| TG gene, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Coronary heart disease risk increases with advancing age and is further increased in patients with mixed dyslipidemia, characterized by elevated low-density lipoprotein cholesterol (LDL-C), low high-density lipoprotein cholesterol (HDL-C), and high triglycerides (TG). | 20960535 |
| Dyslipidemias | Deregulated Nutrient Sensing | The combination of rosuvastatin and fenofibric acid (R + FA) results in more comprehensive lipid improvements than corresponding-dose monotherapies, without additional safety concerns, in elderly patients with mixed dyslipidemia. | 20960535 |
| Polycystic Kidney, Autosomal Dominant, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of the study was to estimate the pancreatic beta cell function and insulin resistance indexes in a group of Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with normal kidney function and no previous diabetes mellitus diagnosis. | 20961181 |
| Alzheimers Disease", Atherosclerosis | Deregulated Nutrient Sensing | This inflammatory status, which has been referred to by the neologism "inflammaging", is of sufficient magnitude to impact health and survival time, and correlates with age-related diseases such as atherosclerosis, insulin resistance and Alzheimer's disease. | 20961694 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nutrient intake in Italian obese patients: relationships with insulin resistance and markers of non-alcoholic fatty liver disease. | 20961734 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | We investigated the prevalence of insulin resistance, elevated liver enzymes, and Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS) in obese and severely obese patients. | 20961734 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Comparison of lymphomononuclear cell energy metabolism between healthy, impaired glucose intolerance and type 2 diabetes mellitus patients. | 20963562 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Linear regression analyses adjusted for sex, awakening time, workday, smoking, blood pressure, BMI, diabetes mellitus, and dyslipidemia showed that older age was associated with a blunted cortisol awakening response. | 20963575 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | The investigated obesity-related cardiovascular risk factors were hyperglycemia, dyslipidemia, and elevated blood pressure. | 20964583 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | High polyphenol chocolate is effective in improving the atherosclerotic cholesterol profile in patients with diabetes by increasing HDL cholesterol and improving the cholesterol:HDL ratio without affecting weight, inflammatory markers, insulin resistance or glycaemic control. | 20968113 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The study subgroups consisted of patients with hypertension (amlodipine) or dyslipidemia (simvastatin). | 20970220 |
| Hypomagnesemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypomagnesemia, a frequent disorder in renal transplant patients related to the use of calcineurin inhibitors (CNIs), plays a causal role in insulin resistance and type 2 diabetes. | 20970568 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors included hypertension (95.8%), dyslipidemia (56.5%), smoking (53.4%), and diabetes (27.2%). | 20970625 |
| glycation | Deregulated Nutrient Sensing | Insulin resistance is an independent correlate of high serum levels of advanced glycation end products (AGEs) and low testosterone in non-diabetic men. | 20972372 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | One hundred thirteen non-diabetic men who did not receive any drugs for hypertension and dyslipidemia underwent a complete history and physical examination, determination of blood chemistries, including serum AGEs and testosterone. | 20972372 |
| Negative Regulation of Cell Cycle | Deregulated Nutrient Sensing | Our results show that a decrease in SIRT1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis. | 20972827 |
| Central neuroblastoma | Deregulated Nutrient Sensing | Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1. | 20972827 |
| Steatohepatitis, Hypertriglyceridemia, Diabetes Mellitus | Deregulated Nutrient Sensing | She lacked insulin resistance, hypertriglyceridemia, hepatic steatosis, and diabetes. | 20979188 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The AMP-activated protein kinase (AMPK) pathway is a master regulator in energy metabolism and may be related to cancer. | 20980414 |
| Increased insulin level, Prediabetes syndrome | Deregulated Nutrient Sensing | A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans. | 20980494 |
| Increased insulin level, Weight decreased | Deregulated Nutrient Sensing | Although lifestyle-induced weight loss improves insulin resistance in prediabetic individuals, postprandial hyperinsulinemia is reduced only when a low-GI diet is consumed. | 20980494 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity is associated with hypertension, dyslipidemia, and diabetes, but it is also an independent cardiovascular risk factor. | 21029823 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | [Prevalence and awareness of dyslipidemia among overweight and obese population in Beijing community]. | 21033142 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | To investigate the prevalence and percentage of dyslipidemia awareness among overweight and obese residents in Beijing community. | 21033142 |
| Dyslipidemias | Deregulated Nutrient Sensing | (2) Prevalence of dyslipidemia increased in proportion with increase of BMI. | 21033142 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The age-standardized prevalence of dyslipidemia of normal, overweight and obese population was 23. | 21033142 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | (3) Unexpectedly, the percentage of dyslipidemia awareness in overweight and obese population was not significantly higher than in the normal body weight group (P > 0.05). | 21033142 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia was high while the percentage of dyslipidemia awareness was rather low in obese population. | 21033142 |
| Alzheimers Disease | Deregulated Nutrient Sensing | [Analysis of correlation between insulin resistance, blood lipids and Alzheimer's disease]. | 21033433 |
| Alzheimers Disease | Deregulated Nutrient Sensing | These suggested that high blood lipids and insulin resistance were probable risk factors of Alzheimer's disease. | 21033433 |
| Inflammation | Deregulated Nutrient Sensing | Decreased high-density lipoprotein cholesterol is associated with inflammation and insulin resistance in non-diabetic haemodialysis patients. | 21040164 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance explains the relationship between novel cardiovascular risk factors and hypertension. | 21042046 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To examine the association between hypertension and new cardiovascular risk factors when considering both classical risk factors and insulin resistance. | 21042046 |
| Refractory anemias, Rheumatoid Arthritis, Atherosclerosis, Chronic inflammatory disorder | Deregulated Nutrient Sensing | The risks of insulin resistance and accelerated atherosclerosis are increased in chronic inflammatory diseases including rheumatoid arthritis (RA). | 21044750 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Adipo-(cyto)kines are associated with insulin resistance, atherosclerosis and inflammation. | 21044750 |
| Depressive disorder | Deregulated Nutrient Sensing | Major depressive disorder and insulin resistance in nondiabetic young adults in the United States: the National Health and Nutrition Examination Survey, 1999-2002. | 21044969 |
| Depression, CTCAE | Deregulated Nutrient Sensing | The association between depression and insulin resistance has been evaluated in previous studies with conflicting results. | 21044969 |
| Minimal Disseminated Disease | Deregulated Nutrient Sensing | Using logistic regression, no significant association was found between MDD and insulin resistance among the nondiabetic young adults in bivariate analysis (b = -0.01, OR = 0.99, 95% CI = [0.38, 2.57], p = .98). | 21044969 |
| Minimal Disseminated Disease | Deregulated Nutrient Sensing | No significant association between MDD and insulin resistance among women was found (b = 0.61, OR = 1.84, 95% CI = [0.47, 7.14], p = .38). | 21044969 |
| Minimal Disseminated Disease | Deregulated Nutrient Sensing | Overall findings suggest there is no significant association between MDD and insulin resistance among nondiabetic young adults aged 20-39 years. | 21044969 |
| East Frisian Low Saxon Language | Deregulated Nutrient Sensing | In addition, triglycerides, fasting insulin, body mass index, LDL-C, hemoglobin A1c, and insulin resistance were significantly associated with FRS. | 21045711 |
| Atherosclerosis | Deregulated Nutrient Sensing | The study population included 954 multi-ethnic non-diabetic adults from the Insulin Resistance Atherosclerosis Study (IRAS). | 21046357 |
| Hypertriglyceridemia, ETV3 wt Allele, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | Logistic regression analysis showed that the obesity, hypertriglyceridemia, MetS and insulin resistance were independent determinants of hyperuricemia in women. | 21046418 |
| Metabolic acidosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes. | 21046483 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Arterial stiffness is strongly associated with insulin resistance in Chinese--a population-based study (Taichung Community Health Study, TCHS). | 21048381 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Few studies have investigated the association between insulin resistance and arterial stiffness in Chinese. | 21048381 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Arterial stiffness is independently associated with insulin resistance in Chinese middle-aged adults. | 21048381 |
| Pancreatic Ductal Adenocarcinoma | Deregulated Nutrient Sensing | Mechanisms for skeletal muscle insulin resistance in patients with pancreatic ductal adenocarcinoma. | 21050717 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Glucose Intolerance (disease), Weight decreased, Pancreatic Ductal Adenocarcinoma | Deregulated Nutrient Sensing | Weight loss, glucose intolerance, and insulin resistance are seen in patients with pancreatic ductal adenocarcinoma (PDAC). | 21050717 |
| Neoplasms | Deregulated Nutrient Sensing | Peripheral insulin resistance is decreased after tumor resection in patients with PDAC, which is consistent with the hypothesis that factors from the tumor may induce skeletal muscle insulin resistance. | 21050717 |
| Weight decreased | Deregulated Nutrient Sensing | In patients with PDAC, muscle insulin resistance is an early and specific finding unrelated to weight loss, plasma free fatty acid levels, and energy status of the cell. | 21050717 |
| Claudication (finding) | Deregulated Nutrient Sensing | Insulin resistance is associated with PAD and may contribute to claudication by impairing skeletal muscle metabolism. | 21051665 |
| Intermittent Claudication | Deregulated Nutrient Sensing | Future studies are required to assess whether calf muscle insulin resistance contributes to exercise limitation in patients with intermittent claudication. | 21051665 |
| Albuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In obese patients with type 2 diabetes, there is an inverse association between adiponectin and low-grade albuminuria, the association being independent of insulin resistance. | 21051904 |
| Neuropathy, Dyslipidemias, Coronary heart disease, Retinal Diseases, Kidney Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia was observed in 78.4%, hypertension in 64.8%, nephropathy in 28.6%, retinopathy in 32.6%, neuropathy in 34.6%, and coronary heart disease in 13%. | 21052999 |
| Non-alcoholic Fatty Liver Disease, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and diabetes mellitus (DM) are known to contribute to the progression of non-alcoholic fatty liver disease (NAFLD). | 21054523 |
| Fatty degeneration | Deregulated Nutrient Sensing | Transaminase activities, g-glutamyl-transpeptidase, serum ferritin levels, homeostasis model assessment of insulin resistance index, and substitutions of amino acid 70 were significantly associated with the presence of steatosis, upon univariate analysis. | 21054524 |
| Steatohepatitis, Glucose Intolerance (disease), Hepatitis C | Deregulated Nutrient Sensing | The hepatitis C virus (HCV) core protein induces hepatic steatosis and glucose intolerance in transgenic mice. | 21054524 |
| Glucose Intolerance (disease), Fatty degeneration | Deregulated Nutrient Sensing | Glucose intolerance was more prevalent in patients with steatosis (63%) than in those without steatosis (32%, P = 0.012). | 21054524 |
| Steatohepatitis, Glucose Intolerance (disease), Hepatitis C, Chronic | Deregulated Nutrient Sensing | Amino acid substitutions in the HCV genotype 1b core region are associated with hepatic steatosis in patients with chronic hepatitis C, independent of glucose intolerance. | 21054524 |
| Inflammation, Cardiac complication, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Low-grade systemic inflammation, oxidative stress and peripheral insulin resistance are intimately associated and contribute to the increased risk of cardiovascular complications in advanced chronic kidney disease (CKD). | 21054584 |
| Vascular lesions, Dyslipidemias | Deregulated Nutrient Sensing | [Relationship between dyslipidemia and early vascular lesions in obese children and adolescents]. | 21055261 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Higher prevalence of hypertension was found in patients with dyslipidemia. | 21055261 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | (2) Vascular lesions are closely related with dyslipidemia, and waist circumference and hypertriglyceridemia are the risk factors. | 21055261 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia as evidenced by the lipid triad: prevalence and associated risk in statin-treated patients in ambulatory care. | 21058895 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Low-IGF1 has been implicated in the etiology of glucose intolerance and subjects with pathological causes of either low- or high-IGF1 are at risk of diabetes. | 21059863 |
| Obesity | Deregulated Nutrient Sensing | Animal studies have revealed the association between stearoyl-CoA desaturase 1 (SCD1) and obesity and insulin resistance. | 21060977 |
| Overweight | Deregulated Nutrient Sensing | The insulin resistance was calculated in 40 morbidly obese patients and 11 overweight controls. | 21060977 |
| Obesity | Deregulated Nutrient Sensing | In conclusion, these data suggest that the regulation of SCD1 is altered in individuals with morbid obesity and that the SCD1 protein has a different regulation in the two adipose tissues, as well as being closely linked to the degree of insulin resistance. | 21060977 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. | 21062352 |
| Prostate carcinoma, Structure of posterior cerebral artery | Deregulated Nutrient Sensing | We recently demonstrated that Sirt1, a NAD(+) -dependent histone deacetylase, was overexpressed in prostate cancer (PCa) and its inhibition resulted in a significant antiproliferative response in human PCa cells. | 21062352 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Studies have suggested a link between Sirt1 and circadian rhythms, the disruption of which has been linked to cancer. | 21062352 |
| Structure of posterior cerebral artery | Deregulated Nutrient Sensing | Here, we challenged our hypothesis that melatonin will impart antiproliferative response against PCa via inhibiting Sirt1. | 21062352 |
| Prostate | Deregulated Nutrient Sensing | This anti-PCa response was accompanied with a significant decrease in Sirt1 in TRAMP prostate. | 21062352 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | As one goal of the MetS definition is to facilitate the clinical identification of insulin-resistant individuals, other biomarkers of insulin resistance have been explored. | 21062616 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance profile among siblings of type 2 diabetes mellitus (preliminary study). | 21063041 |
| Hypertriglyceridemia, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Among subjects with insulin resistance, all have central obesity, half of them have hypertension, decreased HDL cholesterol level and hyper-triglyceridemia. | 21063041 |
| Hypertension, CTCAE, Peripheral Arterial Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Lower-extremity peripheral artery disease (LE-PAD), is strongly related to traditional risk factors (smoking, hypertension, dyslipidemia, diabetes). | 21067754 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | The size of adrenal incidentalomas correlates with insulin resistance. | 21070314 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | Adrenal incidentalomas (AI) have often been associated with a high prevalence of insulin resistance (IR) and cardiovascular risk factors, although direct measurement of insulin sensitivity (IS) has never been carried out. | 21070314 |
| Non-Functioning Endocrine Neoplasm | Deregulated Nutrient Sensing | Our study showed a high prevalence of insulin resistance in patients with nonfunctioning AI and suggests its possible involvement in AI growth. | 21070314 |
| Obesity | Deregulated Nutrient Sensing | Plasminogen activator inhibitor 1 (PAI-1) is thought to play a role in the pathogenesis of obesity and insulin resistance. | 21070757 |
| Ependymoma | Deregulated Nutrient Sensing | mTORC1 activation in childhood ependymoma and response to sirolimus. | 21076853 |
| Neoplasms | Deregulated Nutrient Sensing | Immunohistochemistry for phosphorylated S6, which has been reported to be associated with tumor sensitivity to mTORC1 inhibitors, was positive in this patient's tumor. | 21076853 |
| Anemia | Deregulated Nutrient Sensing | Complete correction of anemia by erythropoiesis-stimulating agents is associated with insulin resistance in hemodialysis patients. | 21076998 |
| Kidney Failure, Chronic, Anemia | Deregulated Nutrient Sensing | Insulin resistance and anemia secondary to erythropoietin deficiency characterize patients with end-stage kidney disease. | 21076998 |
| Disease | Deregulated Nutrient Sensing | Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals. | 21081660 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings show that GES technology can be used for both the discovery of insulin-sensitizing compounds and the characterization of patients into subtypes of insulin resistance according to GES scores, opening the possibility of developing a personalized medicine approach to type 2 diabetes. | 21081660 |
| Colorectal Carcinoma, Obesity | Deregulated Nutrient Sensing | Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. | 21081932 |
| Inflammation, Primary malignant neoplasm, Colorectal Carcinoma, Obesity | Deregulated Nutrient Sensing | This study investigated the relationship of obesity, insulin resistance, inflammation and angiogenesis with cancer progression and survival in a colorectal cancer cohort. | 21081932 |
| Atherosclerosis of renal artery, Apolipoprotein E, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | [Association of the serum level of apolipoprotein E with coronary artery disease and carotid artery atherosclerosis in Kyrgyz men with dyslipidemia]. | 21086615 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and the defective function of pancreatic b-cells can occur several years before the development of type 2 diabetes. | 21087821 |
| Poisoning | Deregulated Nutrient Sensing | The mechanism of action of ILE is not known, including its role in insulin resistance and myocardial metabolism in calcium-channel blocker poisoning. | 21088599 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is an important but modifiable risk factor of cardiovascular disease (CVD) in type 2 diabetes. | 21092182 |
| diabetic | Deregulated Nutrient Sensing | Effects of one year treatment of sibutramine on insulin resistance parameters in type 2 diabetic patients. | 21092710 |
| Gastrointestinal inflammation, Obesity | Deregulated Nutrient Sensing | Based on animal studies, RELMb is induced by high fat diets, obesity, and intestinal microflora and may play a role in insulin resistance and intestinal inflammation. | 21094111 |
| Dyslipidemias | Deregulated Nutrient Sensing | Combinations of statins and fibrates may be increasingly prescribed to achieve lipid goals in high-risk patients and those with other cardiovascular risk factors, such as mixed dyslipidemia. | 21094360 |
| Congestive heart failure | Deregulated Nutrient Sensing | Recently, hemoglobin A1(c) (HbA1(c)) levels have been reported to be an independent risk factor for mortality in CHF, suggesting the important role of insulin resistance in CHF. | 21095280 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are characterized by a chronic and low grade state of inflammation and the pro-inflammatory response of monocytes is affected in type 2 diabetes mellitus (T2D). | 21104588 |
| Diabetes Mellitus, Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance have been linked to rising incidence and earlier onset of Type 1 diabetes. | 21105490 |
| Diabetes Mellitus, Insulin-Dependent, Hereditary | Deregulated Nutrient Sensing | Inherited differences in insulin action might also influence the evolution of Type 1 diabetes.Our aim was to determine whether parental BMI and insulin resistance influences age of onset of Type 1 diabetes in their offspring. | 21105490 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Maternal HOMA-IR accounted for 20% of variation in age at diagnosis (P < 0.001) with increasing maternal insulin resistance associated with later age at diagnosis of Type 1 diabetes. | 21105490 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Childrenwith Type 1 diabetes and their parents have an increased BMI at diagnosis.Maternal insulin resistance is associated with later onset of Type 1 diabetes in children. | 21105490 |
| Prehypertension | Deregulated Nutrient Sensing | Prehypertension and insulin resistance among Mongolian people, Inner Mongolia, China. | 21105761 |
| Prehypertension | Deregulated Nutrient Sensing | There is little knowledge on association of prehypertension with insulin resistance among Mongolian people. | 21105761 |
| Prehypertension | Deregulated Nutrient Sensing | The purpose of the present study is to explore whether there are phenomena of insulin resistance in the phase of prehypertension in the Mongolian population. | 21105761 |
| Hypertension, CTCAE, Prehypertension | Deregulated Nutrient Sensing | Prehypertension was significantly associated with insulin resistance in the Mongolian population, and this study suggest that insulin resistance may play an important role in development of hypertension. | 21105761 |
| Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary heart disease, Depression, CTCAE, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Depression was related to diabetes (OR=1.99, 95% CI=1.26-3.15), dyslipidemia (OR=1.35, 95% CI=1.02-1.79), coronary heart disease (CHD; OR=1.88, 95% CI=1.04-3.39), and the history of stroke (OR=2.43, 95% CI=1.02-5.76). | 21106250 |
| Mitochondria, Muscle | Deregulated Nutrient Sensing | Here, we show that MCAT mice are protected from age-induced decrease in muscle mitochondrial function (~30%), energy metabolism (~7%), and lipid-induced muscle insulin resistance. | 21109199 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | The side-effects associated with androgen deprivation therapy (ADT) include weight gain, dyslipidemia, and insulin resistance. | 21109456 |
| Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | Carotid and femoral plaque burden is inversely associated with the a-linolenic acid proportion of serum phospholipids in Spanish subjects with primary dyslipidemia. | 21111420 |
| Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | Cross-sectional study of 211 patients with primary dyslipidemia, with determination of fatty acid composition of serum phosphatidylcholine by gas chromatography and plaque outcomes (frequency, number, maximum height and sum of plaque heights) in carotid and femoral arteries by sonography. | 21111420 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | In the univariate logistic regression analyses, poor outcomes, defined as mRS scores of >2, at 30 days were significantly related to high serum pentosidine (P = .001), type of stroke (P = .045), old age (P = .02), male sex (P = .042), and the absence of dyslipidemia (P = .02). | 21111635 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | [Insulin resistance in chronic kidney disease: its clinical characteristics and prognosis significance]. | 21113216 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) increases significantly the risk for cardiovascular disease (CV) in the general population. | 21113216 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a strong predictor of myocardial infarction in subjects with chronic kidney disease. | 21114460 |
| Obesity | Deregulated Nutrient Sensing | We hypothesized that the strong association between insulin resistance and circulating amounts of C3 may be related to hepatic fat accumulation -independent of central obesity itself and of a general low-grade inflammatory response. | 21114489 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Plasma ALT can explain 14*2% of the strong association between insulin resistance and circulating concentrations of complement C3, independent of central obesity and general inflammation. | 21114489 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Associations of insulin resistance and adiponectin with mortality in women with breast cancer. | 21115858 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Here, we evaluate whether low levels of adiponectin and a greater level of insulin resistance are associated with breast cancer mortality and all-cause mortality. | 21115858 |
| Data types - Address | Deregulated Nutrient Sensing | We investigated whether fasting glucose and insulin levels and insulin resistance are associated with the risk of AD and whether this risk is constant over time. | 21115952 |
| Breast Carcinoma, Primary malignant neoplasm, Epithelial cell count (procedure) | Deregulated Nutrient Sensing | Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC). | 21116708 |
| Dyslipidemias, Coronary Arteriosclerosis, Metabolic Syndrome X | Deregulated Nutrient Sensing | Patients with metabolic syndrome are at increased risk of atherosclerotic coronary heart disease, often have mixed dyslipidemia, and may thus require more aggressive treatment of multiple lipid parameters. | 21117970 |
| Hyperthyroidism, Glucose Intolerance (disease), Hypothyroidism | Deregulated Nutrient Sensing | Hypothyroidism can decrease insulin requirement in such patients and hyperthyroidism may cause glucose intolerance. | 21121384 |
| Hyperglycemia, Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. | 21121505 |
| Dyslipidemias, Metabolic Syndrome X, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Our data suggest that obesity, hypertension, dyslipidemia, and metabolic syndrome in T2DM were associated with increased plasma leptin levels. | 21121702 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, which has been closely linked to pathophysiology of cardiovascular diseases, is a key independent modifiable risk factor for cardiovascular diseases. | 21122627 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Estimation of the prevalence of dyslipidemia ensures proper planning of health actions for both primary and secondary prevention of cardiovascular diseases. | 21122627 |
| Hyperlipidemia, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | We compared the plasma of patients with combined hyperlipidemia and the dyslipidemia of hypothyroidism with those with type III HL. | 21122636 |
| Inflammatory Bowel Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and lipoprotein profiles in patients with inflammatory bowel disease. | 21122694 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia is a major risk factor for developing coronary artery disease. | 21122694 |
| Inflammatory Bowel Diseases, Dyslipidemias | Deregulated Nutrient Sensing | The purpose of this study is to identify and describe dyslipidemia and lipoprotein profiles in an IBD patient population. | 21122694 |
| Inflammatory Bowel Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Given low levels of HDL-C and increased levels of LDL-C, a more aggressive approach in profiling and treating dyslipidemia seems warranted in patients with IBD. | 21122694 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Serum visfatin is associated with type 2 diabetes mellitus independent of insulin resistance and obesity. | 21122936 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to evaluate the association of serum visfatin, adiponectin and leptin with 2 diabetes mellitus (T2DM) in the context of the role of obesity or insulin resistance, which is not well understood. | 21122936 |
| Obesity | Deregulated Nutrient Sensing | Elevation of visfatin in T2DM is independent of obesity and insulin resistance and is mainly determined by fasting glucose and triglycerides. | 21122936 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. | 21124077 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Deregulated Nutrient Sensing | In tumors from patients with resected NSCLC, expression of proteins in the energy-sensing AMPK pathway (pLKB1, AMPK, p-Acetyl-CoA, pTSC2), adhesion, EGFR, and Rb signaling pathways was inversely associated with NSCLC recurrence. | 21124077 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Toll-like-receptor 4 (TLR) is discussed to provide a molecular link between obesity, inflammation and insulin resistance. | 21125016 |
| Obesity | Deregulated Nutrient Sensing | This finding supports the role of TLR4 as a molecular link between obesity and insulin resistance. | 21125016 |
| HIV Infections | Deregulated Nutrient Sensing | Adiponectin and leptin in Afro-Caribbean men and women with HIV infection: association with insulin resistance and type 2 diabetes. | 21126901 |
| HIV, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and type 2 diabetes (T2D) are commonly seen in human immunodeficiency virus (HIV) infection and are related to antiretroviral therapy. | 21126901 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Prevalences of T2D and insulin resistance were higher in women than in men [16.2% vs 8.3% (P = 0.06) and 24% vs 9.9% (P < 10-3), respectively]. | 21126901 |
| HIV Infections | Deregulated Nutrient Sensing | Insulin resistance is frequent in Afro-Caribbean women with HIV infection. | 21126901 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Systematic screening for insulin resistance should be carried out in this population, which has a high prevalence of T2D. | 21126901 |
| Hyperprolactinemia | Deregulated Nutrient Sensing | Hyperprolactinemia has been associated with impaired metabolism, including insulin resistance. | 21128120 |
| Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, FAM126A gene, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with NAFLD/NASH-associated HCC exhibited a higher prevalence of metabolic features (Type 2 diabetes mellitus, hypertension, dyslipidemia, coronary artery disease) compared to non-NAFLD/NASH-HCC. | 21128245 |
| F11 gene, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | FVIII, FIX, FXI and FXII activities are increased in human NAFLD and correlate with the features of insulin resistance. | 21134109 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) has been associated with cardiovascular diseases (CVD). | 21134267 |
| Glucose Intolerance (disease), Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Chronic exposure to glucocorticoids (GCs) has many side effects including glucose intolerance and diabetes and may accelerate the occurrence of cardiovascular disease and increase mortality. | 21138532 |
| Hyperglycemia | Deregulated Nutrient Sensing | A higher level of insulin resistance as measured by HOMA-IR after the improvement of hyperglycemia (3.6 vs. 6.8) suggested that the long use of olanzapine reduced insulin secretion. | 21139307 |
| Hyperlipidemia, Fatty Liver Disease | Deregulated Nutrient Sensing | The use of policosanols is shown effective in the treatment of associated hyperlipidemia and insulin resistance in patients with fatty liver disease. | 21139538 |
| Atherosclerosis | Deregulated Nutrient Sensing | Losartan, an angiotensin II receptor blocker (ARB), has been reported to increase serum level of high-molecular weight (HMW) adiponectin, which has beneficial effects on insulin resistance and atherosclerosis. | 21142812 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | The interaction between increased hsCRP and GGT was a significant and independent determinant for MetS and insulin resistance in both genders. | 21143879 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | These results suggested that higher CRP and GGT levels were synergistically associated with MetS and insulin resistance, independently of other confounding factor in the general population. | 21143879 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Therapeutic inertia in the outpatient management of dyslipidemia in patients with ischemic heart disease. | 21144403 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Our aims were to investigate this phenomenon, known as therapeutic inertia, in patients with dyslipidemia and ischemic heart disease, and to determine its possible causes. | 21144403 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Therapeutic inertia occurred more frequently when there was a long time between the diagnosis and treatment of dyslipidemia and that of ischemic heart disease. | 21144403 |
| Chronic myocardial ischemia, Dyslipidemias | Deregulated Nutrient Sensing | Therapeutic inertia was common in patients with chronic ischemic heart disease and dyslipidemia, irrespective of overall cardiovascular risk. | 21144403 |
| Constitutional | Deregulated Nutrient Sensing | Sasang constitutional types can act as a risk factor for insulin resistance. | 21146241 |
| Skin Neoplasms | Deregulated Nutrient Sensing | Finally, we show that SIRT1 levels are significantly reduced in human skin tumors from Caucasian patients, a population at highest risk. | 21149730 |
| Neoplasms | Deregulated Nutrient Sensing | These findings suggest that SIRT1 acts as a tumor suppressor through its role in DNA repair. | 21149730 |
| Prostate Cancer Outcomes Study, Dyslipidemias, Hyperandrogenism | Deregulated Nutrient Sensing | Male individuals who are first-degree relatives of patients with PCOS have a higher degree of dyslipidemia and insulin resistance, lower levels of SHBG, and more evident clinical signs of hyperandrogenism. | 21152842 |
| Prostate Cancer Outcomes Study, Hereditary | Deregulated Nutrient Sensing | These findings suggest that insulin resistance may be of hereditary origin in individuals with a family history of PCOS regardless of anthropometric parameters. | 21152842 |
| Intracranial Arterial Diseases, Secondary physiologic amenorrhea, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Radiological studies showed multiple intracranial arterial stenoses, and laboratory examination revealed diabetes mellitus, dyslipidemia, and endocrinological abnormalities consistent with secondary amenorrhea. | 21153600 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been variably associated with insulin resistance and type 2 diabetes (T2D) in several populations. | 21153685 |
| Colorectal Neoplasms, Obesity | Deregulated Nutrient Sensing | Insulin resistance is thought to mediate the association between obesity and colorectal neoplasia, but no prior studies have assessed stimulated insulin sensitivity as a risk factor for colorectal neoplasia. | 21154114 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Insulin resistance and adiponectin are markers of cardio-metabolic disease and associated with adverse cardiovascular outcomes. | 21156037 |
| TG gene, Dyslipidemias, Data types - Address | Deregulated Nutrient Sensing | T2DM is associated with atherogenic dyslipidemia (AD), defined as decreased HDL-C plus raised triglycerides (TG). | 21156040 |
| Obesity | Deregulated Nutrient Sensing | The over-expression of CB1 in adult obesity is associated with insulin resistance (IR),but it is not elucidated in childhood obesity. | 21158212 |
| Obesity | Deregulated Nutrient Sensing | By using multivariate analysis, we found that factors significantly associated with obesity among women were diastolic blood pressure, insulin resistance, and employment status. | 21159215 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Both apoB and apoA1 were significantly associated with obesity when age, sex, diastolic blood pressure, homocysteine, diabetes, and insulin resistance were controlled for. | 21159217 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity. | 21167068 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Therefore, the association among CRP, insulin resistance and obesity was analyzed in Chinese patients with type 2 diabetes. | 21167068 |
| Inflammation, Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings showed that insulin resistance was associated with CRP levels independent of abdominal obesity in Chinese patients with type 2 diabetes, suggesting that abdominal obesity could only partly explain the link between subclinical inflammation and insulin resistance. | 21167068 |
| Malignant neoplasm of prostate, Neurogenic Urinary Bladder, Dyslipidemias, prostatitis, Heart failure, Acute retention of urine, Urethral Stenosis, Diabetes Mellitus, Non-Insulin-Dependent, Liver Cirrhosis | Deregulated Nutrient Sensing | Patients with heart failure, liver cirrhosis, prostatic cancer, neurogenic bladder, acute prostatitis, acute urinary retention, urethral stenosis, history of transurethral resection or any drug treatment for BPH, or currently under drug treatment for type 2 diabetes mellitus or dyslipidemia were excluded. | 21168193 |
| diabetic | Deregulated Nutrient Sensing | These effects are amplified in diabetic individuals with characteristics that are associated with insulin resistance or with oxidative stress. | 21169129 |
| Glucose Intolerance (disease), Acromegaly, Diabetes Mellitus | Deregulated Nutrient Sensing | Frequency of acromegaly in adults with diabetes or glucose intolerance and estimated prevalence in the general population. | 21170595 |
| Ischemia | Deregulated Nutrient Sensing | Autophagy is activated by ischemia and nutrient starvation in the heart through Sirt1-FoxO- and adenosine monophosphate (AMP)-activated protein kinase (AMPK)-dependent mechanisms, respectively. | 21170742 |
| Dyslipidemias | Deregulated Nutrient Sensing | Circulating trans-palmitoleate is associated with lower insulin resistance, presence of atherogenic dyslipidemia, and incident diabetes. | 21173413 |
| Dyslipidemias, Polycystic Ovary Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Polycystic ovary syndrome is associated with subsequent incident diabetes and dyslipidemia, independent of BMI. | 21173640 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation. | 21175613 |
| Kidney Calculi | Deregulated Nutrient Sensing | Impact of insulin resistance, insulin and adiponectin on kidney stones in the Japanese population. | 21175865 |
| Increased insulin level, ETV3 wt Allele, Kidney Calculi | Deregulated Nutrient Sensing | The findings suggest that MetS components could increase the risk of kidney stones through subclinical hyperinsulinemia and insulin resistance. | 21175865 |
| HD Term Type | Deregulated Nutrient Sensing | However, data on insulin resistance and erythropoietin responsiveness in HD patients are lacking. | 21176750 |
| HD Term Type | Deregulated Nutrient Sensing | We conducted a prospective, observational cohort study to clarify the relationship between insulin resistance and erythropoietin responsiveness in HD patients. | 21176750 |
| HD Term Type | Deregulated Nutrient Sensing | Insulin resistance as established by HOMA-IR and adiponectin was associated with EPO responsiveness in HD patients. | 21176750 |
| HD Term Type | Deregulated Nutrient Sensing | Insulin resistance is associated with EPO responsiveness in HD patients. | 21176750 |
| HD Term Type | Deregulated Nutrient Sensing | For improvement in EPO response, insulin resistance may be a new target for treating HD patients. | 21176750 |
| Rhinosinusitis, Osteoporosis, Dyslipidemias, Diabetes Mellitus, Depression, CTCAE | Deregulated Nutrient Sensing | Asthma was also weakly associated with depression, diabetes mellitus, dyslipidaemia, osteoporosis and rhinosinusitis. | 21177843 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | However, it still remains unclear if these elevated IL-6 levels are co-incidental or if this cytokine is causally related to the development of insulin resistance and type 2 diabetes in humans. | 21179199 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Inhibition of IL-6 signalling improves insulin sensitivity in humans with immunological disease suggesting that elevated IL-6 levels in type 2 diabetic subjects might be causally involved in the pathogenesis of insulin resistance. | 21179199 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Patients with CAD, hypertension, dyslipidemia, obesity and high C-reactive protein levels were at high risk of AGM. | 21185615 |
| Hyperlipidemia, Hypertension, CTCAE, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | However, debates still exist on the independent role of hyperuricemia, due to its association with several cardiovascular risk factors, such as hypertension, hyperlipidemia, obesity and insulin resistance. | 21186110 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | insulin resistance is known to be the most important pathogenic factor in the development of nonalcoholic fatty liver disease. | 21187187 |
| Renal Insufficiency, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Further adjustments for obesity, hypertension, insulin resistance, dyslipidemia, and renal dysfunction eliminated these associations. | 21187261 |
| Inflammation, Obesity, Abdominal | Deregulated Nutrient Sensing | ED is decreased in morbidly obese subjects associated with insulin resistance and inflammation parameters although abdominal obesity seems to be of paramount importance in altering this rheological parameter. | 21187580 |
| Tuberculosis, Dyslipidemias, Post-Traumatic Stress Disorder, Anxiety, CTCAE 3.0, Depression, CTCAE, Sleeplessness, Hypertension, CTCAE | Deregulated Nutrient Sensing | Medical conditions included: major depression (45%), PTSD (48%), anxiety (31%), insomnia (50%), hypertension (29%), dyslipidemia (6%), HIV (6%) and tuberculosis class 2-4 (32%). | 21188531 |
| Dyslipidemias, Toxic effect | Deregulated Nutrient Sensing | our findings suggest that atorvastatin and rosuvastatin are preferable to pravastatin for treatment of HIV-infected patients with dyslipidemia, due to greater declines in total cholesterol, LDL-C, and non-HDL-C, with similar lower toxicity rates. | 21189273 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Individuals with SD T2DM are at high risk of CVD as a result of untreated hyperglycaemia, hypertension and dyslipidaemia. | 21194777 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity (46.3% vs 32.0%; P < 0.001), hypertension (86.7% vs 77.8%; P < 0.001), and dyslipidemia (61.2% vs 55.0%; P < 0.05) were significantly more common in women than in men, respectively. | 21195360 |
| Inflammation, Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | Our results suggest that AT inflammation in obese COPD patients relates to insulin resistance. | 21197447 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The rates of hypertension (17%) and dyslipidemia (15%) were lower than rates reported in other national samples; however, the rate for family history of premature heart disease (20%) was similar to those reported in national samples. | 21206350 |
| Hyperparathyroidism, Primary | Deregulated Nutrient Sensing | Primary hyperparathyroidism (PHPT) is characterized by high OC levels and insulin resistance. | 21207016 |
| Schizophrenia | Deregulated Nutrient Sensing | Triglyceride/high-density lipoprotein cholesterol ratio: a surrogate to predict insulin resistance and low-density lipoprotein cholesterol particle size in nondiabetic patients with schizophrenia. | 21208572 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | However, stepwise multiple regression analysis suggested that the triglyceride/HDL ratio is a stronger predictor of insulin resistance and of LDL particle size than other conventional lipoprotein measures after other potential confounding variables, including age, gender, race, family history of diabetes, body mass index, and antipsychotic agent, were taken into consideration (P < .001). | 21208572 |
| Schizophrenia | Deregulated Nutrient Sensing | The triglyceride/HDL ratio, a simple, readily available and inexpensive measure, can be a useful surrogate to identify those with insulin resistance as well as those with more atherogenic small LDL particles in nondiabetic patients with schizophrenia. | 21208572 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance. | 21208674 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories. | 21208674 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | At baseline nearly half the patients (45%) had a diagnosis of hypertension, a third (34%) had dyslipidemia, and 15% had a diagnosis of obesity. | 21209299 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes and dyslipidaemia were independent predictors of decreased primary patency rate (P = 0.013 and P = 0.008, respectively). | 21211456 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with higher BMI and no insulin resistance or diabetes mellitus present better long-term outcomes following anterior AMI. | 21213110 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with MAC were generally older and had a higher prevalence of systemic hypertension, diabetes mellitus, and dyslipidemia. | 21214099 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The prevalence of underweight/overweight, central obesity, dyslipidemia and impaired fasting glucose (IFG) were calculated. | 21214302 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Central obesity increased the chances of IFG (OR:8.000, CI:1.6-39.1) and doubled the prevalence of dyslipidemia (OR:2.190, CI:0.5-9.1). | 21214302 |
| Dyslipidemias, Mental disorders, Diabetes Mellitus | Deregulated Nutrient Sensing | In comparison with other older individuals, those infected with HIV tend to have higher rates of liver-related conditions, diabetes, and dyslipidemia, as well as substance use and psychiatric disorders. | 21216627 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The relation of diabetes, impaired fasting blood glucose, and insulin resistance to left ventricular structure and function in African Americans: the Jackson Heart Study. | 21216853 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans. | 21216853 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients treated with exenatide tended to be obese, middle-aged women on various combinations of OADs and/or insulin who often had hypertension and/or dyslipidemia. | 21219119 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and dyslipidaemia both increase cardiovascular risk in Type 1 diabetes. | 21219421 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | However, little data exist on the associations of insulin resistance to lipids in Type 1 diabetes. | 21219421 |
| Hyperglycemia, Endothelial dysfunction | Deregulated Nutrient Sensing | L-carnitine deficiency may cause changes of NBP by leading to hyperglycemia, insulin resistance and endothelial dysfunction in patients with type-2 DM. | 21220248 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | [Association between both resistin, visfatin and insulin resistance as well as b cell function in the first-degree relatives of type 2 diabetes mellitus]. | 21223671 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To study the association between the levels of serum resistin, visfatin and insulin resistance as well as b-cell dysfunction in the first-degree relatives (FDR) of type 2 diabetes mellitus (T2DM), and to investigate the role of these adipocytokines in pathogenesis of T2DM. | 21223671 |
| Inflammation, Overweight | Deregulated Nutrient Sensing | Healthy men and women with Co-PreHTN+PreDM were, on average, overweight with a large waist circumference, displayed an exacerbated systemic inflammation and higher insulin resistance. | 21228791 |
| Albuminuria | Deregulated Nutrient Sensing | Insulin resistance is associated with reduced serum adiponectin and increased albuminuria levels. | 21229348 |
| SLC25A20 gene, Electrocardiogram: myocardial infarction (finding), Angina Pectoris, Obesity | Deregulated Nutrient Sensing | Among women without CAC, angina was related to variables reflecting obesity and insulin resistance and was independently associated with African-American ethnicity, premature family history of myocardial infarction, and waist circumference (all p < 0.05). | 21232706 |
| No metabolic abnormalities, Overweight | Deregulated Nutrient Sensing | Being overweight with metabolic abnormalities, particularly insulin resistance, low high-density lipoprotein cholesterol level, and visceral adiposity, may adversely influence adolescent bone mass. | 21232765 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma NOx levels did not predict glucose intolerance or insulin resistance before the development of T2D and the increase in plasma NOx levels in T2D was not caused by adiposity. | 21233590 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma NOx concentrations in glucose intolerance and type 2 diabetes. | 21233590 |
| Refractory anemias, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | However, low total physical activity was associated with dyslipidemia, insulin resistance, low levels of atheroprotective anti-PC and consumption of saturated fatty acids, which is of interest in the context of increased frequency of cardiovascular disease in RA. | 21235741 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation. | 21239514 |
| Coronary heart disease, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Adiponectin is present in low concentration in patients with obesity, insulin resistance (IR), Type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). | 21240167 |
| Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | It may be concluded that low serum adiponectin may have some important role in development of CHD and probably low adiponectin and dyslipidemia are linked in the development of atherosclerosis. | 21240167 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Here, we show that SIRT1 protein expression is decreased in muscle biopsies and primary myotubes derived from type 2 diabetic patients, suggesting a contribution of diminished SIRT1 in the determination of muscle insulin resistance. | 21241768 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is hallmarked by insulin resistance and insufficient b-cell function. | 21242957 |
| Hyperthyroidism, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The rate of occurrence of variable glucose intolerance was 28% with frank diabetes mellitus diagnosed in 9% of the cases of hyperthyroidism. | 21243857 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of pitavastatin and atorvastatin on the lipid profile and lipoprotein subclasses were compared in patients with Type 2 diabetes with dyslipidaemia. | 21244474 |
| Inflammation, Hyperparathyroidism, Dyslipidemias, Pathology | Deregulated Nutrient Sensing | On-line high-efficiency HDF resulted in enhanced removal and lower basal levels of small, medium-sized and protein-bound solutes, which are markers or causative agents of uraemic pathologies, mainly inflammation, secondary hyperparathyroidism and dyslipidaemia. | 21245130 |
| Diabetes Mellitus, Non-Insulin-Dependent, physiopathological | Deregulated Nutrient Sensing | Association of restrictive ventilatory dysfunction with insulin resistance and type 2 diabetes in koreans. | 21246464 |
| Demographics Domain, physiopathological, Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate associations of obstructive and restrictive patterns of ventilatory dysfunction with insulin resistance and type 2 diabetes mellitus (DM) in Koreans. | 21246464 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia were present in 88.7% and 65.5% of patients, respectively. | 21247449 |
| Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, these data suggest that a combination of fenofibric acid and a statin could be considered safe and efficacious for treating women with mixed dyslipidemia. | 21247520 |
| Kidney Diseases | Deregulated Nutrient Sensing | Correlates of insulin resistance in older individuals with and without kidney disease. | 21248294 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Chronic kidney disease (CKD) is associated with insulin resistance (IR). | 21248294 |
| Homocysteinemia, Dyslipidemias, Hypertension, CTCAE, Cerebrovascular accident | Deregulated Nutrient Sensing | Cardiovascular risk factors (CVRF) were: dyslipidemia (62.8%), moderate homocysteinemia (55%), BMI>25 (39%) and hypertension (35%) which is associated with a stroke (P<0.0006). | 21248669 |
| Proteinuria, Dyslipidemias, Chronic Kidney Diseases, Lupus Erythematosus | Deregulated Nutrient Sensing | Persistent proteinuria and dyslipidemia increase the risk of progressive chronic kidney disease in lupus erythematosus. | 21248713 |
| Proteinuria, Renal function, Dyslipidemias, Lupus Nephritis | Deregulated Nutrient Sensing | Progressive loss of kidney function developed exclusively in patients with lupus nephritis who had persistent proteinuria and dyslipidemia, although only six required dialysis or transplantation. | 21248713 |
| Proteinuria, Idiopathic glomerular disease, Dyslipidemias, Chronic Kidney Diseases, Lupus Erythematosus | Deregulated Nutrient Sensing | Hence, as in idiopathic glomerular disease, persistent proteinuria and dyslipidemia (modifiable risks) are the major factors for CKD progression in lupus patients with renal involvement. | 21248713 |
| Obesity | Deregulated Nutrient Sensing | In obesity, adipose tissue 11bHSD1 is upregulated, leading to the generation of higher tissue levels of cortisol, which may increase insulin resistance. | 21249616 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We tested the hypothesis that elevated tHcy levels are correlated with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes. | 21250986 |
| Hippocampal atrophy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results indicate that the elevated levels of tHcy in Japanese nondementia patients with type 2 diabetes are characterised by hippocampal atrophy and insulin resistance and that the Z-score and HOMA index may be the primary factors that influence tHcy levels. | 21250986 |
| Metabolic Syndrome X, Cardiovascular Diseases, Increased circulating renin level, Hypoadiponectinemia, Diabetes Mellitus, Non-Insulin-Dependent, MS gene | Deregulated Nutrient Sensing | Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 diabetes (T2DM), metabolic syndrome (MS) and cardiovascular disease. | 21251282 |
| Inflammation, Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Tertiary outcomes will be biochemical markers reflecting common pathophysiological processes of insulin resistance, inflammation and oxidative damage that are assumed to be intertwined in both diabetes and depression. | 21251307 |
| Arthralgia, Hypertension, CTCAE, Dyslipidemias, Osage language | Deregulated Nutrient Sensing | Resolution occurred in 74% of patients with T2DM, 53% with hypertension, 45% with dyslipidemia, 76% with OSA, 38% with joint pain and 20% with depression/anxiety. | 21251414 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Insulin resistance: an independent risk factor for lung cancer? | 21251684 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Insulin resistance is closely associated with numerous metabolic disorders. | 21251684 |
| Carcinogenesis, Carcinoma of lung | Deregulated Nutrient Sensing | Although studies have supported the importance of insulin resistance in carcinogenesis, the existing data have not established its relevance in the context of lung cancer. | 21251684 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Insulin resistance may represent a meaningful risk factor for lung cancer. | 21251684 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Abdominal fat-related activation of the innate immune system and insulin resistance (IR) are implicated in the pathogenesis of cardiovascular diseases. | 21253003 |
| Glucose Intolerance (disease), Cystic Fibrosis | Deregulated Nutrient Sensing | Glucose intolerance in patients with cystic fibrosis: sex-based differences in clinical score, pulmonary function, radiograph score, and 6-minute walk test. | 21255491 |
| Inflammation, Chronic pain, Depression, CTCAE | Deregulated Nutrient Sensing | Patients with CIAP usually suffer from chronic pain and associated depression, both of which have been proposed to cause insulin resistance (IR) by such mechanisms as a sustained increase in the corticosteroids and catecholamines, and chronic low grade inflammation. | 21255940 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | SUBJECT AND AIMS: Endothelial derived nitric oxide (eNOS) is involved in several functions playing important role in development of type 2 diabetes and insulin resistance. | 21256614 |
| Atherosclerosis | Deregulated Nutrient Sensing | However, the relative value of MS, apoB lipoproteins, and estimates of insulin resistance is unknown in predicting atherosclerosis in DM. | 21257006 |
| Calcification of coronary artery, Atherosclerosis | Deregulated Nutrient Sensing | In conclusion, insulin resistance estimates add value to MS and apoB in predicting coronary artery calcification scores in DM and warrant further evaluation in clinic for identification of patients with DM at higher risk for atherosclerotic cardiovascular disease. | 21257006 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Female sex, old age, diabetes mellitus, hypertension, dyslipidemia, and obesity were more prevalent in NSTEACS patients. | 21259279 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Correlates of acute insulin resistance in the early phase of non-diabetic ST-elevation myocardial infarction. | 21262869 |
| glucose metabolism, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin was directly and significantly related to glycaemia (p = 0.0006), body mass index (BMI) (p = 0.00028) and lactate (p = 0.0096) In the early phase of STEMI without previously known diabetes the acute glucose dysmetabolism is quite complex, comprising increased glucose values and the development of acute insulin resistance. | 21262869 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus | Deregulated Nutrient Sensing | Early detection of high-risk individuals for MS using accurate measures of insulin resistance (IR) could improve detection and prevention of CVD and diabetes. | 21262912 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The purposes of this study were to (1) describe anthropometric measures among Korean immigrants with type 2 diabetes mellitus (T2DM) and (2) examine the relationships between measures of obesity with several forms of dyslipidemia in this group. | 21263345 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Obesity, Choline Dehydrogenase, Mitochondrial, Cessation of life | Deregulated Nutrient Sensing | Obesity and dyslipidemia are commonly associated with T2DM, and they are risk factors for coronary heart disease (CHD), the leading cause of death for people with diabetes. | 21263345 |
| Dyslipidemias | Deregulated Nutrient Sensing | Central obesity measures, not BMI, were significantly associated with dyslipidemia in Korean immigrants with T2DM independent of potential confounds such as hemoglobin A1C, cigarette smoking, age, and cholesterol medication. | 21263345 |
| Obesity, Abdominal, Overweight, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Higher values were observed for smoking (65.0%), clinical or laboratory dyslipidemia (59.1% and 52.0%), careless diet (78.4%), sedentary lifestyle (64.2%), overweight or obesity (64.2%) and abdominal obesity (50.9%). | 21265491 |
| Schizophrenia, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Untreated hypertension, untreated dyslipidemia and untreated diabetes are strongly associated with schizophrenia (3.79 [1.63-8.81]), (3.79 [2.06-7.35]), (6.38 [1.725-23.59]), respectively. | 21265491 |
| palladium, Hyperlipidemia, Exocrine pancreatic insufficiency | Deregulated Nutrient Sensing | De novo NAFLD/NASH after PD is characterized by non-obesity and lack of hyperlipidemia and insulin resistance and is associated with pancreatic exocrine insufficiency. | 21267748 |
| Hypertension, CTCAE, Kidney Failure, Dyslipidemias | Deregulated Nutrient Sensing | Patients with renal failure had more often hypertension and dyslipidemia than patients with normal renal function (p<0.001 and p=0.01 respectively). | 21267820 |
| Hypertension, CTCAE, Kidney Failure, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia should be carefully treated to prevent or delay the evolution to the renal failure. | 21267820 |
| Coronary angiography, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | A propensity score matching for angiographic coronary stenosis severity, heart rate, the presence of arterial hypertension and dyslipidaemia was performed using CAD patients of the institutional CFI database (n = 1076) as the control group. | 21270076 |
| Nonalcoholic Steatohepatitis, Hyperinsulinism, Fatty degeneration, Hepatitis | Deregulated Nutrient Sensing | Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C. Fatty acid translocase CD36 (FAT/CD36) mediates uptake and intracellular transport of long-chain fatty acids in diverse cell types. | 21270117 |
| Fatty Liver, Hyperinsulinism, Fatty degeneration, Fatty Liver Disease | Deregulated Nutrient Sensing | Hepatic FAT/CD36 upregulation is significantly associated with insulin resistance, hyperinsulinaemia and increased steatosis in patients with NASH and HCV G1 with fatty liver. | 21270117 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes. | 21270239 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Severe insulin resistance and premature diabetes are common features of PCNT deficiency but are not congenital. | 21270239 |
| Dyslipidemias | Deregulated Nutrient Sensing | Insulin resistance has been reported to be associated with development of atherogenic dyslipidemia. | 21270325 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | However, the confounding effects that obesity and low levels of cardiorespiratory fitness have on the relationship between insulin resistance and the development of atherogenic dyslipidemia remain to be adequately addressed. | 21270325 |
| HIV Infections | Deregulated Nutrient Sensing | We report a case of type B insulin resistance syndrome in a patient with HIV infection on highly active antiretroviral therapy (HAART). | 21270328 |
| HIV Infections | Deregulated Nutrient Sensing | A 27-yr-old African woman with ketosis-prone diabetes and HIV infection developed severe insulin resistance after the initiation of HAART. | 21270328 |
| Immune Reconstitution Inflammatory Syndrome | Deregulated Nutrient Sensing | We report the first case of type B insulin resistance syndrome associated with immune reconstitution inflammatory syndrome in an HIV-infected patient. | 21270328 |
| Ovarian Carcinoma | Deregulated Nutrient Sensing | Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics. | 21271224 |
| ovarian neoplasm, Neoplasms | Deregulated Nutrient Sensing | Recent studies in cell culture models have shown that the growth of tumor cell lines was inhibited by AMPK activation, but the expression of AMPK in human ovarian tumors has not been reported so far. | 21271224 |
| Ovarian Serous Adenocarcinoma, Neoplasms | Deregulated Nutrient Sensing | Decreased AMPK expression correlated significantly with higher tumor grade (p=0.009) and was of adverse prognosis in patients with advanced tumor stages (p=0.016) as well as in patients with serous ovarian carcinomas (p=0.037). | 21271224 |
| ovarian neoplasm | Deregulated Nutrient Sensing | Our results indicate a role for AMPK in progression of ovarian tumors and point towards a prognostic impact of AMPK expression for patient overall survival. | 21271224 |
| Malignant neoplasm of ovary | Deregulated Nutrient Sensing | Furthermore, our data suggest a deregulation of the AMPK-dependent energy metabolism in human ovarian carcinomas. | 21271224 |
| Ovarian Carcinoma, Neoplasms | Deregulated Nutrient Sensing | In future clinical studies, activation of AMPK in ovarian carcinoma patients with advanced tumor stages might be an interesting therapeutic approach. | 21271224 |
| Glucose Intolerance (disease), Fibrosis Assessment | Deregulated Nutrient Sensing | Glucose intolerance is common in cystic fibrosis (CF), and is associated with worsening pulmonary function and nutritional status, and increased mortality. | 21273357 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This case illustrates that CGL should be in the differential diagnosis for non-obese patients with diabetes and insulin resistance. | 21274320 |
| Obesity | Deregulated Nutrient Sensing | Childhood obesity is associated with an increased risk for insulin resistance. | 21274322 |
| Obesity | Deregulated Nutrient Sensing | Since gender, obesity and pubertal status are factors affecting insulin resistance, cut-off values which depend on gender and pubertal status, should be used in evaluation of insulin resistance. | 21274322 |
| Adipose tissue loss, Disease | Deregulated Nutrient Sensing | Lipodystrophies are a group of diseases characterized by loss of fat tissue and are associated with insulin resistance. | 21274335 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is an escalating health problem that is frequently associated with obesity and insulin resistance. | 21274868 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | The mechanistic relationship between NAFLD, obesity, and insulin resistance is not well understood. | 21274868 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Diabetic patients were more often women (42.1% vs 23.1%) and presented a higher prevalence of systemic hypertension, dyslipidemia and family history of coronary artery disease. | 21276955 |
| Quadriplegia, Dyslipidemias | Deregulated Nutrient Sensing | Safety, tolerance, and efficacy of extended-release niacin monotherapy for treating dyslipidemia risks in persons with chronic tetraplegia: a randomized multicenter controlled trial. | 21276961 |
| Quadriplegia, Dyslipidemias | Deregulated Nutrient Sensing | To test the safety, tolerance, and efficacy of extended-release niacin monotherapy on dyslipidemia in persons with chronic tetraplegia. | 21276961 |
| Dyslipidemias, Cerebral Infarction | Deregulated Nutrient Sensing | The effects of the EPA treatment on ADMA in patients in the chronic phase of cerebral infarction accompanied by dyslipidemia were investigated. | 21277225 |
| Dyslipidemias | Deregulated Nutrient Sensing | Study subjects were individuals with either atherothrombotic or lacunar cerebral infarction in the chronic phase accompanied by dyslipidemia, of which the onset was at least 4 weeks earlier. | 21277225 |
| Hyperlipidemia | Deregulated Nutrient Sensing | Risk factors such as hyperlipidemia, impaired glucose tolerance, and insulin resistance have become common. | 21277230 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In age-group stratified analysis, there were no significant associations of insufficient sleep or sleep duration with obesity, diabetes status, or insulin resistance after adjustment for age, race/ethnicity, and gender. | 21278167 |
| Hypertension, CTCAE, Cerebral Infarction, Dyslipidemias | Deregulated Nutrient Sensing | The common risk factors were hypertension (80.3%), dyslipidemia (56.6%), and multiple cerebral infarction (39.9%). | 21280516 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | However, the patients who had dyslipidemia had risk of microalbuminuria 1.784 times of who did not, but no statistically significant (95% CI, 0.79-4.03; p-value > 0.05). | 21280516 |
| Non-alcoholic Fatty Liver Disease, Atherosclerosis | Deregulated Nutrient Sensing | Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study. | 21281435 |
| Atherosclerosis | Deregulated Nutrient Sensing | This analysis was conducted in the Insulin Resistance Atherosclerosis (IRAS) Family Study. | 21281435 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The causal nature of associations between circulating triglycerides, insulin resistance, and type 2 diabetes is unclear. | 21282362 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) and cardiovascular disease may share a common genetic background. | 21282363 |
| Autoimmune Disorder, CTCAE | Deregulated Nutrient Sensing | The type B insulin resistance syndrome, a rare autoimmune disorder, is caused by the autoantibodies to the insulin receptor. | 21284281 |
| Hypogonadism | Deregulated Nutrient Sensing | Hypogonadism in men is associated with insulin resistance, elevations in pro-inflammatory cytokines and fibrinogen, and an atherogenic lipid profile. | 21285084 |
| Dyslipidemias | Deregulated Nutrient Sensing | The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. | 21286016 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity. | 21286016 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Oral glucose test revealed glucose intolerance and hormonal investigation discovered hyperinsulinemia and elevated level of FSH. | 21288754 |
| Impaired | Deregulated Nutrient Sensing | Impaired muscle capillarization and reduced nutrient exposure to the metabolizing tissue may play a major role in the progression of insulin resistance across the glucose tolerance continuum, independent of age, adiposity, lipid status, and resting energy metabolism. | 21289242 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Reduced tissue nutrient exposure may aid in the progression of glucose intolerance. | 21289242 |
| Communicable Diseases, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore intensive management of risk factors (hypertension, diabetes and dyslipidaemia) and prompt recognition of infection is hereby recommended. | 21291114 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Decreased incretin secretion seems to develop early in the course of type 2 diabetes with increasing insulin resistance, but not to be influenced by glycaemic status. | 21292338 |
| Calcification of coronary artery, Atherosclerosis | Deregulated Nutrient Sensing | The relationship between insulin resistance and incidence and progression of coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). | 21292863 |
| Calcification of coronary artery, SLC25A20 gene | Deregulated Nutrient Sensing | We sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC). | 21292863 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Is insulin resistance a risk factor for the progression of chronic kidney disease? | 21293152 |
| Glucose Intolerance (disease), Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The prevalence of overweight-obesity (41.8% vs. 25.5%, p = 0.038), IR (42.9% vs. 23.5%, p = 0.035) and glucose intolerance (15.38% vs. 1.96%, p = 0.043) were significantly higher in PCOS compared to control group. | 21294689 |
| Inflammation, Prostate Cancer Outcomes Study, Dyslipidemias, Hyperandrogenism | Deregulated Nutrient Sensing | PCOS was found to be associated with dyslipidemia, hyperandrogenism, IR and sub-clinical inflammation. | 21294689 |
| IFNG wt Allele, Hyperglycemia, Dyslipidemias, Obesity, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity, hyperglycemia, and dyslipidemia were prevalent and increased from NFG to IFG and T2D. | 21298483 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Relationship between erythropoietin responsiveness, insulin resistance, and malnutrition-inflammation-atherosclerosis (MIA) syndrome in hemodialysis patients with diabetes. | 21298620 |
| Syndrome, diabetic | Deregulated Nutrient Sensing | Diabetic hemodialysis patients with MIA syndrome have a lower response to EPO and a higher resistance to insulin. | 21298620 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These results suggest a different natural history to respect glucose intolerance. | 21300382 |
| Glucose Intolerance (disease), Congestive heart failure | Deregulated Nutrient Sensing | Glucose intolerance is recognized as a predictor of congestive heart failure (CHF). | 21300789 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Two hundred and eighty-seven Japanese subjects who visited the university hospital to be checked for glucose intolerance or known type 2 diabetes were consecutively recruited. | 21300789 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We found prevalence rates of 26%, 48%, and 13% for hypertension, dyslipidemia, and diabetes, respectively. | 21302140 |
| Complications of Diabetes Mellitus, diabetic | Deregulated Nutrient Sensing | Elevated plasma levels of asymmetric dimethylarginine (ADMA) has been reported to be associated with insulin resistance and micro/macrovascular diabetic complications, and may predict cardiovascular events in type 2 diabetic patients. | 21303562 |
| Weakness, Dyslipidemias, Prostate carcinoma | Deregulated Nutrient Sensing | A 64-year-old man who received ketoconazole for prostate cancer, along with simvastatin and fenofibrate for dyslipidemia, presented to our ambulatory clinic with complaints of blood in his urine and weakness following an increase in his ketoconazole dose. | 21304039 |
| Neoplasms | Deregulated Nutrient Sensing | The patient was treated with mammalian target of rapamycin complex 1 (mTORC1) inhibitors, but after 5 months the tumor had progressed. | 21304509 |
| Hereditary Leiomyomatosis and Renal Cell Cancer, Renal Cell Carcinoma, Family history, FH wt Allele | Deregulated Nutrient Sensing | pRCC-2 arising in a patient with a novel germline FH mutation and de novo hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome progressing after mTORC1 inhibitor therapy. | 21304509 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Both altered sympathetic function and insulin resistance have been observed in amyotrophic lateral sclerosis (ALS). | 21305564 |
| Glucose Intolerance (disease), Prediabetes syndrome | Deregulated Nutrient Sensing | The index date was the first pre-diabetes diagnosis (ICD-9 codes 790.21, 790.22, 790.29) or qualifying lab value of fasting plasma glucose or impaired glucose intolerance. | 21306287 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Magnesium levels did not differ between women with and those without insulin resistance, glucose intolerance, or hypertension. | 21306320 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | SirT1 brings stemness closer to cancer and aging. | 21307403 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. | 21307403 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients attended in PC (67% treated with antihypertensive drugs, 31% with BP < 140/90 mmHg, 22% with dyslipidemia and 16% with diabetes), added global CV risk was average or low in 26%, moderate in 31%, high in 27% and very high in 16%; in patients attended in HC (77% treated with antihypertensive drugs, 16% with BP <140/90 mmHg, 47% with dyslipidemia and 26% with diabetes), added global CV risk was average or low in 16%, moderate in 30%, high in 28% and very high in 26%. | 21309358 |
| AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A is an important player in the enhancement of insulin resistance. | 21310413 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Association between obesity history and hand grip strength in older adults--exploring the roles of inflammation and insulin resistance as mediating factors. | 21310808 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | To examine the association between obesity history and hand grip strength, and whether the association is partly explained by subclinical inflammation and insulin resistance. | 21310808 |
| Impulsive Behavior | Deregulated Nutrient Sensing | Excess body fat has been linked to impaired glucose metabolism, insulin resistance, and impulsivity and may be a precursor to decline in attention and executive cognitive function. | 21311507 |
| Dyslipidemias | Deregulated Nutrient Sensing | The combination of Pio with SU or Met may therefore be recommended for T2D second-line therapy in the routine clinical practice, particularly in patients with dyslipidemia. | 21314919 |
| Dyslipidemias, Consensus | Deregulated Nutrient Sensing | For the entire group, dyslipidemia, TransAtlantic InterSociety Consensus II C and D lesions, and angioplasty without stenting negatively affected primary patency. | 21315232 |
| Neoplasms | Deregulated Nutrient Sensing | It has been suggested that adenosine monophosphate-activated protein kinase (AMPK) and 12 AMPK-related kinases (ARK), including novel (nua) kinase family 1 (NUAK1), are activated by master kinase LKB1, a major tumor suppressor. | 21317932 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia and undernutrition in children from impoverished areas of Maceio, state of Alagoas, Brazil. | 21317999 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | We hypothesised that insulin resistance is associated with both angiographically determined coronary artery disease (CAD) and with the MetS. | 21320476 |
| Retinal Diseases | Deregulated Nutrient Sensing | Seven hundred men and women from the DESIR (Data From an Epidemiological Study on the Insulin Resistance Syndrome) Study underwent evaluation for retinopathy using a nonmydriatic digital camera. | 21320965 |
| Hyperglycemia, Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperglycemia, glucose intolerance, hypertension and socioeconomic position in eastern Nepal. | 21323183 |
| Glucose Intolerance (disease), IFNG wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Of urban participants (n = 736) with no history of diabetes 70 (9.5%) had HGY and 143 (19.4%) had glucose intolerance (IFG and IGT). | 21323183 |
| Hyperglycemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Both urban and rural populations are at risk for hyperglycemia and glucose intolerance. | 21323183 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Participants in this sample had insulin resistance, a potent predictor of diabetes. | 21324254 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Prospective evaluation of insulin resistance among endometrial cancer patients. | 21324431 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Whereas diabetes also increases the risk, little is known about related insulin resistance (IR). | 21324431 |
| Hypothyroidism | Deregulated Nutrient Sensing | The primary outcome was progression to overt hypothyroidism, with secondary outcome measures of blood pressure, insulin resistance, lipids, and highly sensitive C-reactive protein (hsCRP). | 21325465 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Mutations in growth signaling pathways extend life span, as well as protect against age-dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. | 21325617 |
| Weight decreased | Deregulated Nutrient Sensing | Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. | 21327867 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, increased muscle (hepatically derived) TAG extraction during postprandial conditions and increased saturation of intramuscular DAG are associated with insulin resistance, suggesting that disturbances in skeletal muscle FA handling could play a role in the development of whole body insulin resistance and type 2 diabetes. | 21331063 |
| Diabetic Nephropathy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results indicate that SIRT1 may play a role in susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. | 21331741 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | We conclude that training determined BP and insulin resistance reduction in SHR, and increased GLUT4 expression in both normotensive and hypertensive rats. | 21332027 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | The association between lipid profiles of 180 CAPD patients and glucose-containing dialysate was analyzed using Pearson methods; 76.56% of NT patients, 66.13% of HD patients, and 72.22% of CAPD patients had dyslipidemia. | 21332332 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | In addition, the results of our investigation, also, demonstrate that the significant correlation between higher percentage of a.s. PSA and the occurrence of NSTEMI persisted after adjustment for traditional CAD risk factors (age, DM, dyslipidemia, and smoking). | 21333366 |
| Dyslipidemias, Sleep Apnea, Obstructive, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | However, 83%, 87%, 67%, and 76% of patients with diabetes, hypertension, dyslipidemia, and obstructive sleep apnea, respectively, experienced improvement or resolution. | 21333610 |
| Peripheral Vascular Diseases, One Vessel Coronary Disease, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The percentage of patients with dyslipidemia, hypertension, triple vessel disease, peripheral vascular disease, and left main disease increased over time (P < .05). | 21334012 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We report the effects of high-dose atorvastatin therapy on cerebral vasomotor reactivity (VMR) in patients with controlled hypertension and dyslipidemia. | 21334223 |
| Hypertension, CTCAE, Ischemic stroke, Dyslipidemias | Deregulated Nutrient Sensing | The majority (61%) had suffered an ischemic stroke and 97.7% presented at least one associated cardiovascular risk factor, being hypertension (84.8%) and dyslipidemia (61.8%) the most frequent. | 21334698 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association between insulin resistance and development of microalbuminuria in type 2 diabetes: a prospective cohort study. | 21335369 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | An association between insulin resistance and microalbuminuria in type 2 diabetes has often been found in cross-sectional studies. | 21335369 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Low 25-OH-D, common in the paediatric population at risk for diabetes (older children, African-Americans, children with increasing BMI-Z) is associated with worse insulin resistance. | 21335626 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. | 21337390 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Nevertheless, the role of SIRT1 in the pathogenesis of osteoarthritis (OA) is still unknown. | 21337390 |
| Degenerative polyarthritis, Hypertrophy | Deregulated Nutrient Sensing | Our observations suggest that SIRT1 expression decreases with development of OA and the reduction of SIRT1 in chondrocytes may cause chondrocyte hypertrophy and cartilage matrix loss. | 21337390 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | SIRT1 might play important roles in the pathogenesis of OA. | 21337390 |
| glycation | Deregulated Nutrient Sensing | Serum advanced glycation end products (AGEs) are associated with insulin resistance. | 21337488 |
| glycation | Deregulated Nutrient Sensing | We have demonstrated that the circulating level of advanced glycation end products is associated with insulin resistance even in non-obese, non-diabetic subjects independent of adiponectin. | 21337488 |
| Psoriatic Juvenile Idiopathic Arthritis, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | On this background we have conducted a pilot study to explore the hypothesis that this modified fatty acid could improve dyslipidemia and reduce inflammation in psoriatic patients. | 21338276 |
| Ischemia, Guinea (geographic area) | Deregulated Nutrient Sensing | The AMPK activity remained unchanged during ischemia in the GIN group, whereas it increased in the control group (P < 0.05). | 21346060 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Compared to other indices of insulin resistance HbA1c has minimal overlap in values (0.0%) between NGT and subjects with type 2 diabetes. | 21348785 |
| Glucose Intolerance (disease), Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Offspring of type 2 diabetics have an increased risk of dyslipidemia, glucose intolerance and obesity. | 21349807 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Type 2 diabetes and diabetic dyslipidemia are high-risk conditions for cardiovascular disease. | 21354969 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to describe diabetic dyslipidemia in a large unselected sample of patients from the Swedish National Diabetes Register. | 21354969 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | The distribution of blood lipids in this large sample of unselected type 2 diabetic patients challenges the previous conception of diabetic dyslipidemia, and calls for new studies to explain the roles of LDL-C and HDL-C as strong cardiovascular risk factors in type 2 diabetes. | 21354969 |
| Heat-Shock Response | Deregulated Nutrient Sensing | TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling. | 21355045 |
| Nerve Degeneration | Deregulated Nutrient Sensing | These results suggest that protein misfolding underlies the aging-dependent neurodegeneration associated with TDP-43 and that the insulin/IGF-1 signaling may be a target for therapies. | 21355045 |
| Dyslipidemias, Lupus Nephritis | Deregulated Nutrient Sensing | There is little data on the prevalence and severity of dyslipidaemia in Asian patients with lupus nephritis (LN). | 21355950 |
| Renal Insufficiency, Dyslipidemias | Deregulated Nutrient Sensing | Whether the dyslipidaemia in LN patients differs from subjects with comparable levels of renal impairment also remains undefined. | 21355950 |
| Proteinuria, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is prevalent in LN patients and is more severe than controls with a similar degree of CKD despite disease quiescence, low steroid dose and low level of proteinuria. | 21355950 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We used the Discriminant Ratio (DR) methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation. | 21356116 |
| Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | We observed no significant association between AMPK genotype and pancreatic cancer and no genotype interactions with diabetes or smoking. | 21357378 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Reduced levels of total osteocalcin (TOC) are associated with adiposity, insulin resistance and type 2 diabetes, implying this bone-derived peptide might modulate cardiovascular risk. | 21359669 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Twenty-eight children had hypercholesterolemia, and 11 had other forms of dyslipidemia. | 21359948 |
| Atherosclerosis | Deregulated Nutrient Sensing | Decreased adiponectin level, the adipose tissues hormone, is related to high body mass and insulin resistance, which are risk factors for atherosclerosis. | 21360915 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity plays a critical role in dyslipidemia and related disorders. | 21361295 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study was designed to investigate the prevalence of type 2 diabetes mellitus and insulin resistance, and to explore the relation between insulin resistance and hepatitis C virus genotype, serum hepatitis C virus-RNA level in chronic hepatitis C (CHC) patients. | 21362362 |
| Carcinogenic Chlorinated Hydrocarbon, Complete atrioventricular block | Deregulated Nutrient Sensing | Insulin resistance was less frequent in CHB than in matched CHC (7.9% vs. 21.4% respectively, P < 0.0001). | 21362362 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. | 21365528 |
| Complication Aspects, Dyslipidemias | Deregulated Nutrient Sensing | Children presented a higher prevalence of insulin resistance and dyslipidaemia compared with adolescents, suggesting that ART, especially PIs, may lead to metabolic complications. | 21371728 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance in renal transplant recipients is associated with increased urinary albumin excretion. | 21376123 |
| Glucose Intolerance (disease), Albuminuria | Deregulated Nutrient Sensing | These results indicated that glucose intolerance is associated with increased albuminuria in renal transplant recipients. | 21376123 |
| Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | High rates of dyslipidemia and insulin resistance (IR) are reported in patients with bipolar disorder (BD). | 21377167 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Short-term RSG therapy reduced insulin resistance, in vivo markers of inflammation and abnormal endothelial function but had no effect on arterial function and stiffness in patients with CKD. | 21378155 |
| Hypodynamia, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | It was shown that the proposed approach allows a few risk factors (dyslipidemia, hypodynamia, arterial hypertension, smoking, and obesity) to be simultaneously corrected. | 21381320 |
| Prostate Cancer, Hereditary, 7, Obesity, Visceral, Obesity | Deregulated Nutrient Sensing | Although many case-control studies have associated obesity to prostate cancer aggressiveness, few have correlated markers of prostate pathology to biomarkers of visceral obesity and insulin resistance, using an apparently healthy cohort. | 21382022 |
| Steatohepatitis, Fibrosis Assessment, Hepatitis C, Hepatitis, Chronic | Deregulated Nutrient Sensing | Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection. | 21382161 |
| Carcinogenic Chlorinated Hydrocarbon, Fatty degeneration, Hepatitis C, Chronic | Deregulated Nutrient Sensing | Steatosis and insulin resistance (IR) are the major disease modifying in patients with chronic hepatitis C (CHC). | 21382161 |
| Malignant tumor of colon, Inflammation | Deregulated Nutrient Sensing | Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer. | 21383385 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | The diagnostic accuracy of these values in identifying MetS was similar to that of insulin resistance. | 21384232 |
| Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Musculoskeletal Diseases, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity is a major risk factor for developing type 2 diabetes, cardiovascular disease, hypertension, dyslipidemias, musculoskeletal diseases, and certain types of cancer. | 21384636 |
| Myocardial | Deregulated Nutrient Sensing | The hexosamine biosynthetic pathway can mediate myocardial apoptosis in a rat model of diet-induced insulin resistance. | 21385329 |
| Fatty infiltration | Deregulated Nutrient Sensing | The state of insulin resistance (calculated by HOMA-IR and WBISI) deteriorated as the degree of fatty infiltration increased. | 21390143 |
| Dyslipidemias, physiopathological, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors for microvascular dysfunction include dyslipidemia, smoking and diabetes. | 21391731 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Residual risk persists despite aggressive low-density lipoprotein cholesterol (LDL-C) reduction in patients with atherosclerotic cardiovascular (CV) disease, many of whom have atherogenic dyslipidemia (low levels of high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, and small dense LDL particles). | 21392609 |
| Dyslipidemias, ciliary vesicle | Deregulated Nutrient Sensing | All study participants had established CV disease and atherogenic dyslipidemia. | 21392609 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | AIM-HIGH enrolled a high-risk group of patients with established atherosclerotic CV disease and atherogenic dyslipidemia. | 21392609 |
| Heart Diseases, Diastolic dysfunction, Bortezomib/Dexamethasone/Pegylated Liposomal Doxorubicin Regimen | Deregulated Nutrient Sensing | Abnormal left ventricular (LV) structure and diastolic function are frequently detected in a variety of heart diseases, and insulin resistance has been suggested to be associated with LV diastolic dysfunction (LVDD). | 21392830 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Mentions of obesity, dyslipidemias, hypertension, and diabetes mellitus increased significantly. | 21393588 |
| Prostate carcinoma, Obesity | Deregulated Nutrient Sensing | Studies have linked prostate cancer risk with insulin resistance and obesity. | 21397927 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia, a major cardiovascular risk factor has been reported to predate the onset of RA, thus suggesting a potential genetic link between the two conditions. | 21398331 |
| Dyslipidemias | Deregulated Nutrient Sensing | Impact of optimal lipid value achievement between 2005 and 2009 in patients with mixed dyslipidaemia on cardiovascular event rates. | 21401832 |
| Dyslipidemias, Coronary Arteriosclerosis, Primary hypercholesterolemia, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | In patients with primary hypercholesterolemia or mixed dyslipidemia, extended-release niacin/laropiprant (ERN/LRPT) improves key lipid parameters associated with increased atherosclerotic coronary heart disease (CHD) risk. | 21401833 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. | 21403394 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Levels of TAGs associated with increased risk for diabetes decreased in response to insulin action and were elevated in the setting of insulin resistance. | 21403394 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Conversely, levels of TAGs associated with decreased diabetes risk rose in response to insulin and were poorly correlated with insulin resistance. | 21403394 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia is an independent risk factor for type 2 diabetes, although exactly which of the many plasma lipids contribute to this remains unclear. | 21403394 |
| Steatohepatitis, Diabetes Mellitus | Deregulated Nutrient Sensing | In chronic hepatitis C, insulin resistance, type 2 diabetes and liver steatosis are frequent and inconsistently correlated to circulating resistin levels. | 21410061 |
| diabetic | Deregulated Nutrient Sensing | Association between improvements in insulin resistance and changes in cognitive function in elderly diabetic patients with normal cognitive function. | 21410855 |
| Mental deterioration, Diabetes Mellitus | Deregulated Nutrient Sensing | Several studies have shown that diabetes is a risk factor for declines in cognitive function and, recently, numerous studies have demonstrated that exercise improves insulin resistance (IR). | 21410855 |
| Steatohepatitis, Non-alcoholic Fatty Liver Disease, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance has an important role in the development of nonalcoholic fatty liver disease (NAFLD) and is involved in both pathological processes: hepatic steatosis and atherosclerosis. | 21411114 |
| Diabetes Mellitus, Non-Insulin-Dependent, Sleep disturbances, Diabetes Mellitus | Deregulated Nutrient Sensing | The observed association between poor sleep quality and higher glucose, insulin, and estimated insulin resistance among subjects with diabetes warrants further examination of the effect of sleep disturbances on glucose control in type 2 diabetes. | 21411507 |
| macroangiopathy, Dyslipidemias, Disease of capillaries, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia and a high body mass index were significantly associated with macroangiopathy, while diabetes of long duration and a high concentration of HbA1c were associated with microangiopathy. | 21411989 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Also, Arabs were more likely to be obese (OR = 1.72; 95% CI: 1.19-2.50) and have diabetes (OR = 1.41; 95% CI: 1.01-1.96), while Jews were more likely to have dyslipidemia (OR = 1.56; 95% CI: 1.11-2.17). | 21411992 |
| Breast Carcinoma, Obesity | Deregulated Nutrient Sensing | High circulating glucose, insulin resistance and obesity appear to be associated with increased risk of breast cancer (BC). | 21413010 |
| Hyperglycemia | Deregulated Nutrient Sensing | The results of this study add to the existing epidemiological evidence that hyperglycemia and insulin resistance increase BC risk. | 21413010 |
| Alopecia, CTCAE | Deregulated Nutrient Sensing | Androgenetic alopecia and insulin resistance: are they truly associated? | 21413951 |
| Androgenetic Alopecia | Deregulated Nutrient Sensing | Controversies exist regarding the association of androgenetic alopecia (AGA) with insulin resistance. | 21413951 |
| Non-alcoholic Fatty Liver Disease, Colorectal Carcinoma | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of insulin resistance (IR), and IR is associated with an increased risk of colorectal carcinoma (CRC). | 21414047 |
| Steatohepatitis, Glucose Intolerance (disease), Adenoma of large intestine | Deregulated Nutrient Sensing | Multivariate regression analyses demonstrated an independent association of colorectal adenomas with hepatic steatosis after adjustment for age, sex, body mass index and glucose intolerance (OR 1.47; 95% CI 1.079-2.003; P = 0.015). | 21414047 |
| Inflammation, Malignant neoplasm of endometrium, Obesity | Deregulated Nutrient Sensing | The association between obesity and endometrial cancer risk in postmenopausal women may be attributed to inflammation, insulin resistance, and elevated estrogen. | 21415362 |
| methionine | Deregulated Nutrient Sensing | Affymetrix 133v2 arrays identified GMNN, MET, CCNE2, SIRT1 and CDK6 as miR-449 targets. | 21418558 |
| methionine | Deregulated Nutrient Sensing | Luciferase assays were used to confirm GMNN, MET, CCNE2 and SIRT1 as direct targets. | 21418558 |
| Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Coronary plaques were more frequent in patients with stroke, diabetes, hypertension, and dyslipidemia than in patients without these conditions (all p values <0.001). | 21420050 |
| Dyslipidemias, Hypertrophy | Deregulated Nutrient Sensing | Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women. | 21421806 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | All analyses were adjusted for age, education, living arrangements, Duke Social Support grouping, smoking, and history of diabetes, hypertension, and dyslipidemia. | 21422905 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Eighty-three percent of patients received the recommended care for cardiovascular risk factors, including >75% for hypertension, dyslipidemia and diabetes. | 21424868 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The overall risk of developing diabetes mellitus and glucose intolerance seems to be higher in women with polycystic ovary syndrome (PCOS) than in healthy women. | 21427116 |
| Inflammation, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | In this population, high RBC EPA and DHA were associated with attenuated dyslipidemia and low-grade systemic inflammation among overweight and obese persons. | 21427737 |
| Hyperhomocysteinemia, Metabolic Syndrome X | Deregulated Nutrient Sensing | Several observations suggest that there might be links between hyperhomocysteinemia and insulin resistance, its clinical surrogate of metabolic syndrome. | 21428179 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | The mechanism by which iron load induces insulin resistance is possibly independent of the pathways involved in insulin resistance induced by fatty liver disease. | 21430023 |
| Carcinoma of lung | Deregulated Nutrient Sensing | The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival. | 21430184 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | The aim of this study is to investigate the prognostic role of phosphorylated AMP-activated protein kinase (pAMPK) in surgically resected non-small-cell lung cancer (NSCLC). | 21430184 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Our results support further evaluation of AMP-activated protein kinase as a potential prognostic and therapeutic target for lung cancer. | 21430184 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | An increase in the proportion of hypertension and dyslipidemia awareness, treatment, and control in all educational level groups was observed. | 21435903 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The diagnosis is clinical and there is no treatment for it but recognition is necessary to minimize early atherosclerosis through the control of dyslipidemia. | 21437546 |
| Osteoporosis | Deregulated Nutrient Sensing | Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. | 21437719 |
| Dyslipidemias | Deregulated Nutrient Sensing | In the KDM group 63% had dyslipidaemia (low HDL cholesterol or elevated triglycerides) vs. 80% in the SDM group, p = 0.32. | 21438763 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In the long term, smoking and dyslipidemia were the main predictors of CKD. | 21440776 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance (IR) is highly prevalent in chronic hemodialysis (CHD) patients and is associated with poor cardiovascular outcomes. | 21441124 |
| Obesity | Deregulated Nutrient Sensing | Identification and functional characterization of a missense mutation in resistin in two patients with severe obesity and insulin resistance. | 21441316 |
| Obesity | Deregulated Nutrient Sensing | Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. | 21442217 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | RBP4 plays a role in biological mechanisms that are responsible for insulin resistance and development of type 2 diabetes. | 21442217 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Improvement of insulin resistance and reduction of cardiovascular risk among obese patients with type 2 diabetes with the duodenojejunal bypass liner. | 21442376 |
| Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | The DJBL, when used for a period of 6 months, is effective in the control of diabetes, weight loss, improvement of insulin resistance, and decrease of cardiovascular risk among morbidly obese patients with type 2 diabetes mellitus. | 21442376 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia is one of the primary causes for coronary artery disease (CAD). | 21446364 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | There was no significant effect of insulin resistance and NASH on whole body rate of protein turnover [phenylalanine Ra (rate of appearance)] and on the rate of urea synthesis. | 21446920 |
| Autoimmune Diseases, Obesity | Deregulated Nutrient Sensing | Data collection and analyses will focus on determining the phenotype of islet autoimmunity, genotypes of T1D- and type 2 diabetes-associated genes, insulin resistance, and b-cell function, growth, obesity, and physical exercise. | 21446926 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | Human resistin is an adipokine, with a possible link to coronary heart disease, and the relationship between serum resistin, insulin resistance, and type 2 diabetes mellitus (T2DM) remains controversial. | 21447495 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Several in vitro studies have suggested the effects of adipokines and insulin resistance on breast cancer cell proliferation and survival. | 21450081 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Of PCOS features, an elevated free T level was most predictive of insulin resistance. | 21450287 |
| Irregular Menstruation | Deregulated Nutrient Sensing | Menstrual irregularity and polycystic ovary morphology were not associated with insulin resistance (56.3% vs. 52.9% and 60.0% vs. 34.4%, respectively). | 21450287 |
| Dyslipidemias | Deregulated Nutrient Sensing | Results suggest that residual dyslipidemia in statin-treated patients at low cardiovascular risk may be reduced by increasing statin dose. | 21450578 |
| diabetic | Deregulated Nutrient Sensing | In asymptomatic and fairly controlled diabetic patients, age, worse HbA1c, traits of insulin resistance, such as visceral adiposity and triglycerides or treatment with metformin, and use of doxazosin indicate greater risk of LVD. | 21450640 |
| Electrocardiogram abnormal, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The following risk factors were independent predictors of electrocardiographic abnormalities: male gender (P = .006), diabetes mellitus (P = .0001), and dyslipidemia (P = .001). | 21453931 |
| Celiac Disease, Dyslipidemias, Liver Dysfunction | Deregulated Nutrient Sensing | Before 2007, none of the patients had screening performed for celiac disease, dyslipidemia, or liver dysfunction, and none had routine electrocardiography or cardiac magnetic resonance imaging. | 21454226 |
| Celiac Disease, Dyslipidemias, Congenital Abnormality | Deregulated Nutrient Sensing | Since 2007, 63% were screened for celiac disease, 54% for liver abnormalities, and 38% for dyslipidemia. | 21454226 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. | 21455728 |
| Dyslipidemias | Deregulated Nutrient Sensing | PIOfix-study: effects of pioglitazone/metformin fixed combination in comparison with a combination of metformin with glimepiride on diabetic dyslipidemia. | 21457065 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia in patients with type 2 diabetes is characterized by elevated triglyceride levels, decreased high-density lipoprotein (HDL) cholesterol, and a predominance of small dense low-density lipoprotein (LDL) particles. | 21457065 |
| Depressed mood, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Elevated levels of plasma homocysteine and depressed ghrelin levels have been found to be associated with insulin resistance in a number of clinical situations, such as polycystic ovary syndrome. | 21458334 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The management of cardiovascular risk factors such as hypertension and dyslipidemia is poorly described in many communities, and the benefits associated with tighter control remain unknown. | 21459263 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | A systematic evaluation of the insulin resistance syndrome as an independent risk factor for cardiovascular disease mortality and derivation of a clinical index. | 21459390 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance-related risk factor clustering (the insulin resistance syndrome or IRS) may be a cardiovascular disease (CVD) risk factor, but a convincing demonstration of this requires a rigorously derived reference measure and a systematic evaluation of measures and indices that derive from that measure. | 21459390 |
| Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Lymphotoxin-a 252 A>G polymorphism: a link between disease susceptibility and dyslipidemia in rheumatoid arthritis? | 21459939 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | The LTA 252 A/A genotype translates to a phenotype more prone to dyslipidemia, and the G/G genotype to a phenotype with earlier onset of disease and higher levels of CRP, when RA does occur. | 21459939 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | These observations highlight a possible common genetic predisposition to RA and dyslipidemia. | 21459939 |
| melanoma | Deregulated Nutrient Sensing | We used a public array comparative genomic hybridization (CGH) database and real-time quantitative PCR (qPCR) analyses to identify the AMP kinase (AMPK)-related kinase NUAK2 as a candidate gene for melanomagenesis, and we analyzed its functions in melanoma cells. | 21460252 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK has antioncogenic properties. | 21460252 |
| Dyslipidemias, Hypertension, CTCAE, Endothelial dysfunction, Obesity, Visceral | Deregulated Nutrient Sensing | Hypertension in postmenopausal women are usually associated with other cardiovascular risk factors, such as dyslipidemias, visceral obesity and endothelial dysfunction. | 21463249 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Majority of patients were males, associated with dyslipidaemia, hypertension and smoking. | 21465976 |
| Weight decreased | Deregulated Nutrient Sensing | Insulin resistance influences weight loss in non-obese women who followed a home-based exercise program and slight caloric restriction. | 21466903 |
| Non-insulin Hypoglycemic, Weight decreased | Deregulated Nutrient Sensing | Insulin resistance facilitated weight loss, and home-based exercise promoted greater weight loss only in non-insulin resistance women. | 21466903 |
| Weight Gain | Deregulated Nutrient Sensing | Early effects of smoking cessation and weight gain on plasma adiponectin levels and insulin resistance. | 21467702 |
| Weight Gain | Deregulated Nutrient Sensing | Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance. | 21467702 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is an important risk factor for myocardial infarction (MI). | 21468600 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome. | 21469322 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes. | 21470285 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | There is a high prevalence of low testosterone and dyslipidaemia in men with type 2 diabetes. | 21470285 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1. | 21471201 |
| Dyslipidemias, Atherosclerosis, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of airflow obstruction in patients with atherosclerosis (29.3%) was greater than that in patients with dyslipidemia (24.3%), diabetes mellitus (23.1%) or hypertension (27.1%). | 21473425 |
| Obesity | Deregulated Nutrient Sensing | The observed increase of triglycerides after glucose load in subjects with signs of insulin resistance and obesity suggests that post-glucose triglyceride change is a potential novel biomarker for early detection of metabolic risk. | 21474138 |
| Steatohepatitis, Obesity, Abdominal | Deregulated Nutrient Sensing | The specific association of post-glucose triglyceride change with abdominal obesity and fasting glucose suggests a link to hepatic steatosis and insulin resistance. | 21474138 |
| Hypertensive (finding), Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The most prevalent cardiovascular risk factor was dyslipidaemia, found in 80.4% (37.9% with treatment), followed by abdominal obesity, in 45.9% of the hypertensive patients. | 21474438 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients referred from the ED were less likely to have a diagnosis of hypertension, dyslipidemia, or diabetes, but were more likely to smoke. | 21474891 |
| Dyslipidemias, Efficiency | Deregulated Nutrient Sensing | These findings suggest that increased muscular efficiency at low exercise intensity and reduced lipid oxidation during rest and exercise may contribute to both dyslipidemia and increased adiposity in individuals with ALP. | 21475144 |
| Primary Biliary Cholangitis | Deregulated Nutrient Sensing | Contribution of zinc deficiency to insulin resistance in patients with primary biliary cirrhosis. | 21476007 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | The relationship between metabolic abnormalities of trace elements and insulin resistance has been established. | 21476007 |
| Primary Biliary Cholangitis | Deregulated Nutrient Sensing | The purpose of this study was to examine the correlation between zinc or copper metabolism and insulin resistance in patients with primary biliary cirrhosis (PBC). | 21476007 |
| Fibrosis Assessment, Primary Biliary Cholangitis | Deregulated Nutrient Sensing | These results suggest that zinc deficiency plays important roles of insulin resistance and subsequent hepatic fibrosis in patients with PBC, although insulin resistance in advanced stage PBC was significantly milder than that in HCV-related liver cirrhosis. | 21476007 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Obesity increases the risk for cardiovascular risk factors (CVRFs), including hypertension, dyslipidaemia and type 2 diabetes. | 21478001 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | In men, 37% of dyslipidaemia (30% in women) could be attributed to overweight and obesity; overweight had a higher contribution than obesity in both sexes. | 21478001 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Overweight, Obesity | Deregulated Nutrient Sensing | Overall, approximately 27,000 cases of type 2 diabetes, 63,000 cases of high blood pressure and 37,000 cases of dyslipidaemia could have been avoided if overweight and obesity levels were maintained at 1992 levels. | 21478001 |
| diabetic | Deregulated Nutrient Sensing | Characterisation of non-obese diabetic patients with marked insulin resistance identifies a novel familial partial lipodystrophy-associated PPARg mutation (Y151C). | 21479595 |
| LMNA wt Allele, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In the present study we aimed to identify cases of FPLD among non-obese patients with type 2 diabetes mellitus and marked insulin resistance. | 21479595 |
| diabetic | Deregulated Nutrient Sensing | We searched the databases of three diabetic outpatient clinics for patients with marked insulin resistance, arbitrarily defined as the use of >=100 U insulin/day, and BMI <= 27 kg/m(2). | 21479595 |
| Neoplasms | Deregulated Nutrient Sensing | Resveratrol induces SIRT1- and energy-stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment. | 21479886 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes. | 21480966 |
| Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | The aim of this study was to compare the effects of calorie-restricted vegetarian and conventional diabetic diets alone and in combination with exercise on insulin resistance, visceral fat and oxidative stress markers in subjects with Type 2 diabetes. | 21480966 |
| Visceral | Deregulated Nutrient Sensing | The greater loss of visceral fat and improvements in plasma concentrations of adipokines and oxidative stress markers with this diet may be responsible for the reduction of insulin resistance. | 21480966 |
| Obesity | Deregulated Nutrient Sensing | Plasma phospholipid transfer protein activity is independently determined by obesity and insulin resistance in non-diabetic subjects. | 21481395 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated plasma PLTP activity levels are reported in obesity and diabetes mellitus, but the relative contributions of obesity and insulin resistance to plasma PLTP activity remain unclear. | 21481395 |
| Obesity | Deregulated Nutrient Sensing | We tested whether plasma PLTP activity is independently related to (central) obesity and insulin resistance in non-diabetic subjects. | 21481395 |
| Obesity | Deregulated Nutrient Sensing | In non-diabetic subjects, both obesity and insulin resistance influence plasma PLTP activity, resulting in elevated plasma PLTP activity particularly with combined increases in obesity and insulin resistance. | 21481395 |
| Obesity | Deregulated Nutrient Sensing | Higher PLTP activity could contribute to elevated cardiovascular risk in the presence of obesity and insulin resistance. | 21481395 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | We interviewed overweight/obese [Body Mass Index (BMI) >= 85th percentile], 12-18-yr old adolescents with T2DM, prediabetes, or insulin resistance (IR) and a parent. | 21489091 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus. | 21489574 |
| Pulmonary arterial hypertension, Polycyclic Hydrocarbons, Aromatic | Deregulated Nutrient Sensing | Animal and human data suggest insulin resistance is common in pulmonary arterial hypertension (PAH). | 21493097 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Although routine assessment of insulin resistance is difficult, hemoglobin A(1c) (HbA(1c)) is a sensitive test to detect diabetes mellitus (DM) and those at high risk for DM. | 21493097 |
| Pulmonary arterial hypertension, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Unrecognized glucose intolerance is common in pulmonary arterial hypertension. | 21493097 |
| Dyslipidemias | Deregulated Nutrient Sensing | The present study was conducted to investigate the role of plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels, a regulator of LDL-receptor expression, in the occurrence of diabetic dyslipidemia. | 21497351 |
| Dyslipidemias | Deregulated Nutrient Sensing | These observations should be regarded as hypothesis generating for further studies aimed at elucidating the role of PCSK9 in the pathogenesis and treatment of diabetic dyslipidemia. | 21497351 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | The following conditions were evaluated: dyslipidemia, systemic arterial hypertension, and type 2 diabetes. | 21499023 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and hyperuricemia were 41.7% and 27.8%, respectively. | 21499989 |
| Increased insulin level, Fatty replacement of skeletal muscle | Deregulated Nutrient Sensing | Higher concentrations of CRP appear to be associated with greater skeletal muscle AT infiltration, lower subcutaneous AT, hyperinsulinemia, and insulin resistance. | 21501070 |
| Cataract | Deregulated Nutrient Sensing | Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. | 21501079 |
| Radiation Arc | Deregulated Nutrient Sensing | This study was to investigate the expression of SIRT1 in human lens epithelial cells, and to observe the changes in SIRT1 expression and its downstream P53 and forkhead box class O (FOXO) proteins at the onset of ARC. | 21501079 |
| Radiation Arc | Deregulated Nutrient Sensing | In contrast, the expression of Bim was lowest in the ARC lens, and TUNEL assay showed significantly increased apoptosis incidence in group C. The expression of SIRT1 increased in ARC in humans. | 21501079 |
| Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Prehypertension | Deregulated Nutrient Sensing | Cardiovascular disease (CVD) risk, insulin resistance and b-cell function in prehypertension population of China. | 21501840 |
| Impaired T cell function, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To explore the cardiovascular disease (CVD) risk in prehypertensive subjects and evaluate whether high blood pressure (BP) is associated with insulin resistance (IR) and b-cell dysfunction. | 21501840 |
| Cell secretion, Fibrosis Assessment | Deregulated Nutrient Sensing | Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients. | 21502328 |
| Hyperglycemia, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Fifteen percent of CF patients had glucose intolerance and 6% had diabetes without fasting hyperglycemia and 3% had diabetes with fasting hyperglycemia. | 21502328 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pulmonary function impairment has a connection with abdominal obesity, type 2 diabetes, and insulin resistance. | 21502707 |
| Obesity | Deregulated Nutrient Sensing | The degrees of obesity and insulin resistance were both negatively associated with esterification-related parameters and positively with FAO (P < 0.05). | 21505146 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | Insulin resistance at different stages of diabetic kidney disease in India. | 21510112 |
| Chronic Kidney Diseases, Kidney Diseases | Deregulated Nutrient Sensing | Many studies showed that Insulin resistance (IR) is present in chronic renal failure and evidences suggest that IR can also occur in early stages of renal disease. | 21510112 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | There is paucity of data from India, hence this study was planned to assess the degree of Insulin resistance at different stages of diabetic nephropathy. | 21510112 |
| Dyslipidemias, Cachexia, atherosclerotic | Deregulated Nutrient Sensing | We tested a hypothesis that dyslipidemia increases the risk of incident atherosclerotic CVD and that protein energy wasting (PEW) increases the risk of fatality after CVD events in hemodialysis patients. | 21511840 |
| Cessation of life, Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | In this hemodialysis cohort, dyslipidemia was associated with increased risk of incident atherosclerotic CVD, and protein energy wasting/inflammation with increased risk of death after CVD events. | 21511840 |
| Atrial Fibrillation by ECG Finding, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | Risk for atrial fibrillation in patients with hypertrophic cardiomyopathy: association with insulin resistance. | 21515029 |
| Atrial Fibrillation, Health maintenance, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | We also evaluated the relation between the development of atrial fibrillation (AF) and insulin resistance (IR) in patients with HCM. | 21515029 |
| Inflammation, Dyslipidemias, atherosclerotic, Obesity | Deregulated Nutrient Sensing | Obesity related dyslipidemia, chronic inflammation and oxidative stress were associated with atherosclerotic sequels. | 21515245 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The Akt2 gene is not a major cause of diabetes in a non-obese Chinese Han population characterized by insulin resistance. | 21518566 |
| Dyslipidemias | Deregulated Nutrient Sensing | Results indicate a high prevalence of dyslipidemia, and an increase of excess weight and sedentary activity between both surveys. | 21519701 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | In comparison to the control group, RA patients showed a higher prevalence of associated dyslipidaemia (95.7% versus 65.9% of cases, p < 0.001). | 21523363 |
| Refractory anemias, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | Corticoid dose was not associated to dyslipidaemia, but in multiple regression models, corticoid dose may be negatively related to some atherogenic markers, in particular non-HDL-c. Tunisian patients with markedly active RA experience substantially reduced serum HDL-c and increased TC, LDL-c and Lp (a) concentrations as well as increased TC/HDL-c, LDL-c/HDL-c and non-HDL-c/HDL-c ratios. | 21523363 |
| Chronic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes is a chronic disease that is characterized by an increased blood glucose level due to insulin resistance. | 21523426 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The authors'; findings indicate another reason to fight the increasing prevalence of obesity and dyslipidemia. | 21523720 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Traditional cardiovascular risk factors were highly prevalent (hypertension 45.2%, diabetes 25.8%, dyslipidemia 38.7%, nicotine use 45.2%). | 21523886 |
| Angiomyolipoma of kidney | Deregulated Nutrient Sensing | This study investigated the efficacy and safety of the mTORC1 inhibitor sirolimus for treatment of renal angiomyolipomas in patients with these disorders. | 21525172 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with T2DM and dyslipidemia under metformin monotherapy with hemoglobin A1c value between 6.5% and 9.0% were eligible for trial participation. | 21527115 |
| Inflammation, Sarcopenia, Malnutrition, Chronic disease | Deregulated Nutrient Sensing | The causes of sarcopenia are multifactorial and can include disuse, altered endocrine function, chronic diseases, inflammation, insulin resistance, and nutritional deficiencies. | 21527165 |
| FAM126A gene | Deregulated Nutrient Sensing | In this study, we found that SIRT1 is essential for the tumorigenesis of HCC. | 21527554 |
| FAM126A gene | Deregulated Nutrient Sensing | We showed that although SIRT1 was expressed at very low levels in normal livers, it was overexpressed in HCC cell lines and in a subset of HCC. | 21527554 |
| Neoplasms, FAM126A gene | Deregulated Nutrient Sensing | Tissue microarray analysis of HCC and adjacent nontumoral liver tissues revealed a positive correlation between the expression levels of SIRT1 and advancement in tumor grades. | 21527554 |
| FAM126A gene | Deregulated Nutrient Sensing | Downregulation of SIRT1 consistently suppressed the proliferation of HCC cells via the induction of cellular senescence or apoptosis. | 21527554 |
| FAM126A gene | Deregulated Nutrient Sensing | There was also a positive correlation between the level of induction of SIRT1 and TERT [corrected] in human HCC. | 21527554 |
| FAM126A gene | Deregulated Nutrient Sensing | Finally, SIRT1-silencing sensitized HCC cells to doxorubicin treatment. | 21527554 |
| FAM126A gene | Deregulated Nutrient Sensing | Together, our findings reveal a novel function for SIRT1 in telomere maintenance of HCC, and they rationalize the clinical exploration of SIRT1 inhibitors for HCC therapy. | 21527554 |
| Liver carcinoma, Neoplasms | Deregulated Nutrient Sensing | Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. | 21527554 |
| Spinal Cord Injuries, Stanford Cancer Institute, Dyslipidemias | Deregulated Nutrient Sensing | Describe the management of dyslipidemia and adherence to the National Cholesterol Educational Program (NCEP) guidelines in men with Spinal Cord Injury (SCI). | 21528624 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was well controlled in low risk individuals, but control was less common in higher risk individuals. | 21528624 |
| Dyslipidemias, Stanford Cancer Institute, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is common in men age 45-70 with chronic SCI and no evidence of clinical cardiovascular disease. | 21528624 |
| Hypertriglyceridemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | The presence of family history, puberty, insulin resistance and hypertriglyceridemia constitute important risk factors for developing hypertension. | 21528810 |
| Obesity | Deregulated Nutrient Sensing | The relationship between serum phosphate levels with childhood obesity and insulin resistance. | 21528821 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Incidence of diabetes mellitus, hypertension, and dyslipidemia increased as BMI increased (p <0.05). | 21529741 |
| Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity is a major risk factor for development of insulin resistance, a proximal cause of type 2 diabetes and is also associated with an increased relative risk of Alzheimer's disease. | 21538175 |
| Weight Gain, "Alzheimers Disease", Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Our results indicate that Alzheimer's disease increases susceptibility to body weight gain induced by HFD, and to the associated glucose intolerance and insulin resistance. | 21538175 |
| Alzheimers Disease", Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein. | 21538175 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The mechanism(s) behind this glucose intolerance in PSEN1 and APP/PSEN1 mice appeared to involve increased levels of brain retinol-binding protein 4 and basal phosphorylation of S6 ribosomal protein, and decreased insulin-stimulated phosphorylation of Akt/protein kinase B and extracellular signal-regulated kinase 1/2 in the brain. | 21538175 |
| Inflammation, Vascular Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance, inflammation, and vascular disease in nondiabetic predialysis chronic kidney disease patients. | 21538390 |
| Cardiovascular morbidity, Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality, which is not fully explained by traditional risk factors; hence, the interest in nontraditional risk factors such as inflammation and insulin resistance (IR). | 21538390 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. | 21540183 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | SIRT1 is involved in the pathogenesis of obesity, diabetes, and aging. | 21540183 |
| Obesity | Deregulated Nutrient Sensing | In vivo, SIRT1 undergoes an extensive degradation in hepatocytes in obesity as a consequence of persistent activation of JNK1. | 21540183 |
| Steatohepatitis | Deregulated Nutrient Sensing | The degradation leads to inhibition of SIRT1 function, which contributes to development of hepatic steatosis. | 21540183 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | The JNK1-SIRT1 pathway provides a new molecular mechanism for the pathogenesis of hepatic steatosis in obesity. | 21540183 |
| Hyperglycemia, Acute heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Acute hyperglycemia and insulin resistance in acute heart failure syndromes without previously known diabetes. | 21544537 |
| Acute heart failure, F8 wt Allele | Deregulated Nutrient Sensing | No data is so far available on the relation between glucose values and insulin resistance and mortality, both at short- and long-term, in patients with acute heart failure syndromes (AHF). | 21544537 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | About 67% of the patients had dyslipidaemia, 14.3% had type 2 diabetes mellitus and 59.2% had systemic arterial hypertension. | 21545540 |
| Dyslipidemias, Psoriasis | Deregulated Nutrient Sensing | The Psoriasis Area and Severiy Index were equal or over 10 in 27 patients, 18 of whom had dyslipidaemia (P = 0.929) and 14 of whom had the MS (P = 0.327). | 21545540 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustment for covariates, the Hp2-2 genotype (vs. Hp1-1; OR 3.841) remained significantly associated with the development of CKD, together with diabetes (OR 3.131), hypertension (OR 1.748) and dyslipidemia (OR 1.646). | 21546768 |
| Low Back Pain, Osteoporosis, palladium, Parkinson Disease, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Depression, CTCAE, Arthritis, Hypertension, CTCAE | Deregulated Nutrient Sensing | This study was designed to evaluate the impact of other common self-reported comorbid disorders (hypertension, dyslipidemia, ischemic heart disease, diabetes mellitus, minor stroke, arthritis, low back pain or osteoporosis and depression) on health-related Quality of Life (HRQoL) of Parkinson's disease (PD) patients and to explore the association of their HRQoL with various sociodemographic and clinical factors. | 21547746 |
| Dyslipidemias, Pulmonary Embolism | Deregulated Nutrient Sensing | Dyslipidemia as a long-term marker for survival in pulmonary embolism. | 21549676 |
| Presenile dementia, Dyslipidemias, Neoplasms | Deregulated Nutrient Sensing | Factors independently associated with reduced survival rate were: creatinine levels > 2 (OR, 8.8; 95% CI, 1.1 - 70.87), previous neoplasm (OR, 8.8; 95% CI, 3.69 - 20.98), dementia (OR, 6.85; 95% CI, 2.1 - 22.33) and dyslipidemia (OR, 5.07; 95% CI, 1.92 - 13.44). | 21549676 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is getting important in the course of type 1 diabetes mellitus. | 21553302 |
| diabetic | Deregulated Nutrient Sensing | This measurement may point to the presence of insulin resistance in type 1 diabetic patients. | 21553302 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults. | 21556362 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Previous studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. | 21556362 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older. | 21556362 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese. | 21556362 |
| diabetic | Deregulated Nutrient Sensing | AAS have the potential to induce or exacerbate diabetic conditions due to decreased glucose tolerance and increased insulin resistance. | 21558143 |
| Hyperlipidemia, Non-alcoholic Fatty Liver Disease, Overweight, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperlipidemia, overweight, insulin resistance and hypertension are associated with non-alcoholic fatty liver disease. | 21561285 |
| Inflammation | Deregulated Nutrient Sensing | Biomarkers of inflammation, the level of oxidative stress, insulin resistance, and serum vitamin D levels were measured. | 21562784 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | In patients with NAFLD and atherogenic dyslipidemia appointment of combination therapy of statins and probiotics are more effective in lowering cholesterol and products of metabolism of intestinal microflora compared with monotherapy. | 21563361 |
| Dyslipidemias | Deregulated Nutrient Sensing | Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipidaemia: a prospective randomised open-label study. | 21564441 |
| Dyslipidemias, FBN2 wt Allele, Dental Plaque, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, atherosclerotic | Deregulated Nutrient Sensing | A specific longitudinal gradient of strain (reduced strain, i.e., lower radial strain at the plaque level than at the adjacent segment) has been shown in atherosclerotic plaques on the common carotid artery (CCA) in patients with hypertension, dyslipidemia, or type 2 diabetes mellitus. | 21565733 |
| Hypoadiponectinemia, Dyslipidemias | Deregulated Nutrient Sensing | HIV patients on antiretroviral therapy (ART) have a unique dyslipidemia [elevated triglycerides and non-high-density lipoprotein-cholesterol (HDL-C), low HDL-C] with insulin resistance (characterized by hypoadiponectinemia). | 21565796 |
| Hypoadiponectinemia, Dyslipidemias | Deregulated Nutrient Sensing | Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive," a randomized, controlled trial. | 21565796 |
| Hypoadiponectinemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | A combination of fenofibrate and niacin with low-saturated-fat D/E is effective and safe in increasing HDL-C, decreasing non-HDL-C and hypertriglyceridemia, and ameliorating hypoadiponectinemia in patients with HIV/ART-associated dyslipidemia. | 21565796 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | A post hoc analysis of data collected by a prospective cluster randomized trial with 7041 patients diagnosed with clinical atherosclerosis requiring secondary prevention of dyslipidemia and 127 primary care physicians over an 18-month period. | 21566005 |
| Liver carcinoma | Deregulated Nutrient Sensing | Expression and role of SIRT1 in hepatocellular carcinoma. | 21567102 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Silent mating type information regulation 2 homolog 1 (SIRT1) is a multifaceted, nicotinamide adenine dinucleotide-dependent protein deacetylase with involvement in a wide variety of cellular processes ranging from cancer to aging. | 21567102 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | Expression of SIRT1 was evaluated in 90 cases of hepatocellular carcinoma (HCC) and five HCC cell lines. | 21567102 |
| FAM126A gene | Deregulated Nutrient Sensing | Expression of SIRT1 was significantly elevated in the HCC tissues when compared to that of non-tumor tissues (p<0.001). | 21567102 |
| Virus Diseases | Deregulated Nutrient Sensing | Expression of SIRT1 showed significant correlation with gender (p=0.023), serum AFP levels (p=0.030), viral infection (p=0.005) and p53 expression (p<0.021). | 21567102 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1 silencing was found to induce cell growth arrest in HCC cells. | 21567102 |
| Primary malignant neoplasm, FAM126A gene | Deregulated Nutrient Sensing | These results suggest an association of SIRT1 expression with HCC development and that SIRT1 plays a role in cancer cell growth. | 21567102 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is mainly caused by insulin resistance. | 21569294 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with undiagnosed diabetes had a lower prevalence of hypertension, dyslipidaemia, peripheral vascular disease and previous myocardial infarction than those with clinical diabetes and similar to that of those without diabetes. | 21569580 |
| Cerebrovascular Disorders, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The predictors for a pathological ABI included male gender, smoking, dyslipidemia, family history of premature cardiovascular disease, sedentary lifestyle, diabetic-related complications, heart and cerebrovascular diseases. | 21570647 |
| Dyslipidemias | Deregulated Nutrient Sensing | Persistent dyslipidemia is a reality in statin-treated patients and may contribute to their residual cardiovascular risk. | 21574067 |
| Dyslipidemias | Deregulated Nutrient Sensing | Adiponectin may also be associated with insulin resistance, dyslipidemia, and the inflammatory response in these patients. | 21574896 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | C57BL/6J and 129S6/Sv (B6 and 129) mice differ dramatically in their susceptibility to developing diabetes in response to diet- or genetically induced insulin resistance. | 21576825 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Hypertension occurred in 75.8% of the patients, dyslipidemia in 52.6%, and obesity in 57.1%. | 21584418 |
| Obesity, Abdominal, Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Regarding RF, 76.3% presented dyslipidemia, 52.7% abdominal obesity, 48.1% arterial hypertension, and 42.3% whole body obesity. | 21584430 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is often associated with hypertension, and many clinical trials have shown that lipid-lowering therapy and strict blood pressure (BP) control are important for preventing cardiovascular disease (CVD). | 21593784 |
| Dyslipidemias | Deregulated Nutrient Sensing | In patients with mild-to-moderate dyslipidaemia, elevated BP increases the risk for CVA/TIA and other CVD, and rigorous BP control was important for preventing CVD, in particular CVA/TIA. | 21593784 |
| Dyslipidemias | Deregulated Nutrient Sensing | A significant interaction among BMI, dyslipidemia, and APOE genotype was observed that could identify elderly patients with different risks of mortality. | 21595502 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and central obesity affected 84.6%, 76.8%, and 53.5% of patients, respectively. | 21599865 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Overall, more than half (58.1%) had any of the considered comorbidities; hypertension (36.1%), dyslipidemia (27.0%) and diabetes (15.1%) being the most common. | 21599917 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | CAD prevalence increases with age, dyslipidemia, and hypertension, but we did not detect an independent prognostic effect of CAD on mortality. | 21600533 |
| Diabetes Mellitus, Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance and hypertension in patients with type 1 diabetes. | 21601483 |
| Kidney Failure, Chronic, Ventricular hypertrophy | Deregulated Nutrient Sensing | Insulin resistance and left ventricular hypertrophy in end-stage renal disease: association between the ENPP1 gene and left ventricular concentric remodelling. | 21602183 |
| Kidney Failure, Chronic, Left Ventricular Hypertrophy, Ventricular hypertrophy | Deregulated Nutrient Sensing | Left ventricular hypertrophy (LVH) and insulin resistance (IR) are frequent complications of end-stage renal disease (ESRD). | 21602183 |
| Obesity | Deregulated Nutrient Sensing | Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. | 21602837 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Overweight was associated with socioeconomic, demographic, and morbidity variables such as hypertension and dyslipidemia. | 21603763 |
| Glucose Intolerance (disease), Atherosclerosis | Deregulated Nutrient Sensing | The effect of non-diabetic glucose intolerance on early atherosclerosis is not as straightforward, and the data regarding sex-related differences in this matter are limited. | 21604003 |
| Carotid Atherosclerosis, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes and non-diabetic glucose intolerance are associated with increased early carotid atherosclerosis compared with normal glucose tolerance in both sexes. | 21604003 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Our results suggest that women with glucose intolerance may be in greater risk than men. | 21604003 |
| Lichen Planus, Dyslipidemias | Deregulated Nutrient Sensing | Recently a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients. | 21605731 |
| Lichen Planus, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Chronic inflammation in patients with lichen planus may explain the association with dyslipidemia. | 21605731 |
| Fatty Liver, Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Consumption of sugar-sweetened beverages has been shown to be associated with dyslipidemia, insulin resistance, fatty liver, diabetes, and cardiovascular disease. | 21613559 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | High surgical risk (P<0.0001), diabetes (P=0.004), dyslipidemia (P=0.006) and elevated levels of NT-proBNP (P<0.0001) were significantly correlated with events. | 21617607 |
| Overweight | Deregulated Nutrient Sensing | Lower extremity fat mass is associated with insulin resistance in overweight and obese individuals: the CARDIA study. | 21617639 |
| Dyslipidemias, physiopathological | Deregulated Nutrient Sensing | Our objectives were to elucidate whether (1) the cerebrovascular eNOS-H2O2 pathway was sensitive to oxidative stress associated with aging and dyslipidemia and (2) TXA2 contributed to cerebral eNOS dysfunction. | 21617900 |
| Dyslipidemias | Deregulated Nutrient Sensing | Thromboxane synthase inhibition by furegrelate increased dilations at 12 months in WT and at 3 and 12 months in ATX mice, suggesting an anti-dilatory role of TXA2 with age hastened by dyslipidemia. | 21617900 |
| Dyslipidemias, Precocious | Deregulated Nutrient Sensing | In conclusion, the age-dependent cerebral endothelial dysfunction is precocious in dyslipidemia and involves TXA2 production that limits eNOS activity. | 21617900 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | Erythrocyte membrane contents of MUFA and oleic acid were found to be associated with VC scores determined using plain radiographs and with dyslipidemia in patients undergoing HD. | 21620727 |
| Acute Coronary Syndrome, Dyslipidemias, Chronic heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | IM patients were more likely to have acute coronary syndromes, acute rather than exacerbation of chronic heart failure, and diabetes mellitus and dyslipidemia. | 21627393 |
| Increased insulin level, Inflammation | Deregulated Nutrient Sensing | Serum TBil concentrations were inversely associated with hyperinsulinemia, insulin resistance, and systemic inflammation. | 21631904 |
| Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | Despite their beneficial effects on weight loss and blood lipids, high-protein (HP) diets have been shown to increase insulin resistance and diabetes risk, whereas high-cereal-fiber (HCF) diets have shown the opposite effects on these outcomes. | 21633074 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | We analyzed whether common variants in the gene encoding CB1, CNR1, are associated with insulin resistance, risk of type 2 diabetes (T2D) or coronary heart disease (CHD). | 21633404 |
| Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Although supported by initial results, we found no reproducible statistical association of common variation at CNR1 with insulin resistance, T2D, or CHD. | 21633404 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and type 2 Diabetes have been associated to a low grade of inflammation and their prevalence increase with ageing. | 21635187 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | High serum fasting peptide YY (3-36) is associated with obesity-associated insulin resistance and type 2 diabetes. | 21635925 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Although high PYY(3-36) is strongly linked to obesity and associated insulin resistance, the relation between PYY(3-36) and type 2 diabetes is independent of body fatness. | 21635925 |
| Aneuploidy | Deregulated Nutrient Sensing | Our data highlight new role for SIRT1 in maintenance of chromosome stability in mitosis and suggests how diminished SIRT1 activity during aging and tumorigenesis may lead to aneuploidy and genomic instability. | 21636977 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | [Therapeutic approach to dyslipidemia and goal achievement in a Spanish population with type 2 diabetes without cardiovascular disease]. | 21641286 |
| Diabetes Mellitus, Non-Insulin-Dependent, Chronic disease | Deregulated Nutrient Sensing | Indirectly, results also implicate muscle as a potential mediator between poor fetal growth and adult chronic disease, given muscle's direct role in determining insulin resistance, type II diabetes, physical activity, and so forth. | 21641734 |
| Malnutrition, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia can be found in patients with malnutrition, a severe condition that needs prompt nutrition intervention. | 21642469 |
| Malnutrition, Dyslipidemias | Deregulated Nutrient Sensing | This report describes a case of malnutrition causing severe dyslipidemia in a newborn. | 21642469 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Association of insulin resistance with arterial stiffness in nondiabetic peritoneal dialysis patients. | 21643643 |
| Kidney Failure, Chronic, Cardiovascular morbidity | Deregulated Nutrient Sensing | Insulin resistance is a risk factor for cardiovascular morbidity and mortality in the general and end-stage renal disease populations. | 21643643 |
| Arterial Stiffness, palladium | Deregulated Nutrient Sensing | In this study, we investigated the association between insulin resistance and arterial stiffness in nondiabetic peritoneal dialysis (PD) patients. | 21643643 |
| Arterial Stiffness, palladium | Deregulated Nutrient Sensing | Insulin resistance is an independent risk factor for arterial stiffness in PD patients older than 50 years. | 21643643 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | [Association of the genetic variations of bone morphogenetic protein 7 gene with diabetes and insulin resistance in Xinjiang Uygur population]. | 21644225 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The present study suggests that the rs6025422 polymorphism in (BMP7) gene may be associated with diabetes mellitus and insulin resistance in Uygur men. | 21644225 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile and insulin resistance, which can contribute to the development of coronary artery disease (CAD). | 21645024 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Demographics, clinical symptoms, cardiovascular status and risk factors--central obesity, hypertension, dyslipidaemia, smoking. | 21650069 |
| Proteinuria, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with diabetes, BMI >=30 kg/m(2), and who had the blood collection during the winter or spring had lower levels of 25(OH)D. Serum 25(OH)D correlated inversely with parathyroid hormone, proteinuria, insulin resistance, leptin, and subcutaneous abdominal fat. | 21652219 |
| Tumor necrosis | Deregulated Nutrient Sensing | By ingenuity pathway analysis, the tumour necrosis factor receptor 1 (TNFR1) signaling pathway was most affected by metformin: TGFB and MEKK were upregulated and cdc42 downregulated; mTOR and AMPK pathways were also affected. | 21655990 |
| Failure | Deregulated Nutrient Sensing | The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. | 21656330 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The drug treatments for hypertension, dyslipidemia, and diabetes increased in a similar pattern. | 21659455 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Criteria-wise insulin resistance, hypertriglyceridemia and low high density lipoprotein also were found at significantly higher rate among obese children. | 21660399 |
| Cardiovascular system | Deregulated Nutrient Sensing | Recent publications point towards psoriasis-induced insulin resistance as an important pathomechanism driving cardiovascular comorbidity in these patients. | 21660442 |
| Inflammation | Deregulated Nutrient Sensing | SHBG performed well as a sensitive biomarker for insulin resistance and systemic inflammation in these patients. | 21660442 |
| Metabolic Diseases, Dyslipidemias | Deregulated Nutrient Sensing | The main presentation of metabolic disease in Thai patients was dyslipidemia. | 21666699 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | The dyslipidemia associated with excess weight is a risk profile global call for cardiovascular disease (CVD). | 21666967 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The low HDL-c was the most prevalent dyslipidemia in all adolescents and hypertriglyceridemia was most prevalent in overweight adolescents. | 21666967 |
| Presenile dementia, Dyslipidemias | Deregulated Nutrient Sensing | Apart from dyslipidemia, there were no associations between dementia and the other vascular risk factors. | 21668914 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of angiotensin I converting enzyme, angiotensin II type 1 receptor and angiotensin I converting enzyme 2 gene polymorphisms with the dyslipidemia in type 2 diabetic patients of Chinese Han origin. | 21670585 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The above 3 polymorphisms were genotyped in a total of 282 patients with T2D and dyslipidemia (Group A), 182 patients with T2D but without dyslipidemia (Group B), and 324 healthy controls. | 21670585 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Furthermore, the ID genotype had a decreased risk of developing T2D without dyslipidemia as compared with controls (OR=0.52, 95% CI=0.32-0.82; p=0.0060). | 21670585 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The distributions of the AT1R (rs5186) and ACE2 (rs2285666) genotypes and alleles did not differ between T2D patients with or without dyslipidemia and the controls. | 21670585 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study demonstrates that the ACE (I/D) polymorphism is associated with T2D, regardless of the absence or presence of dyslipidemia. | 21670585 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of SUMO4 Met55Val variation with increased insulin resistance in newly diagnosed type 2 diabetes in a Chinese population. | 21671169 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To further examine the related mechanisms, this study was designed to evaluate the association of SUMO4 Met55Val polymorphism with insulin resistance and b cell function in newly diagnosed type 2 diabetic patients in a Chinese population. | 21671169 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It was concluded that SUMO4 Met55Val variant was associated with increased insulin resistance in Chinese patients with newly diagnosed type 2 diabetes. | 21671169 |
| Hypophosphatemia | Deregulated Nutrient Sensing | Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expression. | 21672148 |
| Thrombus, Dyslipidemias | Deregulated Nutrient Sensing | Thrombotic risk factors were found in 43 patients; the most frequent was dyslipidemia (n = 22) followed by oral contraceptive use (n = 18). | 21672438 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia (P = .012), diabetes (P = .054), and comorbid dyslipidemia and diabetes (P = .006) were more common in the unexplained group. | 21672496 |
| Cessation of life, Dyslipidemias, Psychiatric, Diabetes Mellitus | Deregulated Nutrient Sensing | The role of diabetes and dyslipidemia as risk factors for sudden death in psychiatric patients requires careful longitudinal studies. | 21672496 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Potential benefit of statin therapy for dyslipidemia with chronic kidney disease: Fluvastatin Renal Evaluation Trial (FRET). | 21673461 |
| Cardiovascular morbidity, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a common complication of chronic kidney disease (CKD) and contributes to cardiovascular morbidity and mortality of CKD patients. | 21673461 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypoglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Additive effects of glycaemia and dyslipidaemia on risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish National Diabetes Register. | 21674176 |
| physiopathological, diabetic | Deregulated Nutrient Sensing | ET-1 not only induces vascular dysfunction but also acutely impairs FGU in individuals with insulin resistance and in skeletal muscle cells from type 2 diabetic subjects. | 21677282 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The associations between G972R polymorphism of the IRS-1 gene, insulin resistance, salt sensitivity and non-dipper hypertension. | 21677657 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | On a high-salt diet, patients with the G972R polymorphism had an increased risk for insulin resistance (odds ratio (OR)=11.42, 95% confidence interval (CI) 7.68-28.44), salt sensitivity (OR=5.38, 95% CI 1.14-25.34) and non-dipper hypertension (OR=3.6, 95% CI 1.07-12.09). | 21677657 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | In conclusion, the results of our study suggest that the G972R polymorphism of the IRS-1 gene is associated with insulin resistance, salt sensitivity and non-dipper hypertension. | 21677657 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. | 21677689 |
| Pancreatic carcinoma, Neoplasms | Deregulated Nutrient Sensing | We investigated the expression of SIRT1 in pancreatic cancer and the effect of SIRT1-targeted RNA interference (RNAi) on cell proliferation and tumor formation in a pancreatic cancer cell line, PANC1. | 21677689 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | The expression of SIRT1 was investigated in 49 specimens of pancreatic cancer and adjacent normal pancreatic tissues. | 21677689 |
| Neoplasm Metastasis, Neoplasms, Secondary malignant neoplasm of liver, TNM Staging System, Pancreatic carcinoma | Deregulated Nutrient Sensing | SIRT1 was overexpressed in pancreatic cancer tissues at both the mRNA and protein levels, with increased SIRT1 positivity associated with tumors from patients over 60 years old, tumors larger than 4 cm, higher TNM (extent of tumor (T), the extent of spread to lymph nodes (N), and presence of distant metastasis (M)) stage or the presence of lymph node or hepatic metastases. | 21677689 |
| Neoplasms | Deregulated Nutrient Sensing | Additionally, PANC-1-SIRT1-RNAi cells had a significantly reduced capacity to form tumors in vivo compared with untransfected and PANC-1-negative RNAi cells. | 21677689 |
| Neoplasms, Pancreatic carcinoma | Deregulated Nutrient Sensing | These results suggest that SIRT1 may promote cell proliferation and tumor formation in pancreatic cancer, and downregulation of SIRT1 using shRNA could provide a novel therapeutic treatment. | 21677689 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The levels of SHBG were associated negatively with the risk of T2D, obesity and insulin resistance in both men and women. | 21679181 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low levels of testosterone and SHBG increase the risk of T2D in men, and high levels of testosterone increase the risk of insulin resistance in women. | 21679181 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The association between TT levels and the risk of T2D is not completely independent of other variables, such as exposure time, adiposity, insulin resistance or SHBG levels. | 21679181 |
| Hypertension, CTCAE, Scotoma, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Forty-three per cent presented with visual field defects, 49% had hypertension, 25% diabetes mellitus and 35% dyslipidaemia. | 21679284 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | There were significant associations between the following risk factors: age, obesity, smoking, hypertension, dyslipidemia, and increased severity of ED (P<0.05 for each). | 21679302 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Persistent lipid abnormalities in statin-treated patients with diabetes mellitus in Europe and Canada: results of the Dyslipidaemia International Study. | 21679231 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | [Correlation study on different dyslipidemia classification and glucose metabolism in patients with hyperlipidemia]. | 21681276 |
| Hypertriglyceridemia, Adenoma of large intestine, Dyslipidemias | Deregulated Nutrient Sensing | The findings of this study suggest that dyslipidemia may affect the incidence of colorectal adenoma, particularly hypertriglyceridemia and low HDL-C levels. | 21681277 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Stroke is associated with markers of insulin resistance, low serum levels of HDL, and high total cholesterol/HDL ratio in this African population. | 21683619 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | There is an increasing body of literature showing associations of organochlorine exposure with risk of diabetes and insulin resistance. | 21684538 |
| Maturity Onset Diabetes of the Young Pathway, Diabetes Mellitus, Insulin Resistance, Overweight, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described b-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. | 21688019 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity together with dyslipidemia, smoking, diabetes and high blood pressure intensifies oxidative stress. | 21688559 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Reduced sleep duration was associated with obesity and atherogenic dyslipidemia in young school children in Hong Kong. | 21689984 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Many patients with coronary artery disease have insulin resistance and altered energy metabolism, which can exacerbate around the time of coronary revascularization. | 21693564 |
| Psoriasis, Demographics Domain, Refractory anemias, Diabetes Mellitus, Rheumatoid Arthritis | Deregulated Nutrient Sensing | Rheumatoid arthritis (RA) and psoriasis have been linked with insulin resistance and diabetes mellitus (DM). | 21693740 |
| Obesity, Fatty Liver Disease | Deregulated Nutrient Sensing | Alcohol consumption was inversely associated with insulin resistance, independent of central obesity, metabolic profiles, and fatty liver diseases. | 21694610 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Correlation of insulin resistance, beta cell function and insulin sensitivity with serum sFas and sFasL in newly diagnosed type 2 diabetes. | 21695404 |
| Structure of beta Cell of islet | Deregulated Nutrient Sensing | Our findings suggest that the pancreatic beta cell dysfunction along with increased insulin resistance appears to be associated with apoptotic markers. | 21695404 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Brain volume reductions have also been associated with chronic low-grade inflammation and dyslipidaemia. | 21695767 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | This study investigated the relationships among T2DM, gender, inflammation, dyslipidaemia, and hippocampal volumes. | 21695767 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia (hypercholesterolemia and/or hypertriglyceridemia) was defined according to the American Academy of Pediatrics AAP) guidelines. | 21696080 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Odds ratio ofhaving dyslipidemia in overweight and/or obese children compared to non-obese children was 4.0 (95% CI 2.0-8.0). | 21696080 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. | 21697301 |
| Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese. | 21697301 |
| Inflammation, Kidney Diseases, Retinal Diseases, Neuropathy | Deregulated Nutrient Sensing | PAD; SMI; ED; 24-hour blood pressure Holter; lipid profile; insulin resistance; testosterone; chronic inflammation; nephropathy; retinopathy; neuropathy. | 21699670 |
| Cataract, Abnormally opaque structure (morphologic abnormality) | Deregulated Nutrient Sensing | To evaluate the correlation between the severity of lens opacity, patient age, and the level of silent information regulator T1 (SirT1) expression in the lens epithelium of age-related cataracts. | 21700104 |
| Abnormally opaque structure (morphologic abnormality) | Deregulated Nutrient Sensing | The expression of SirT1 in lens opacity was significantly less in patients 51 years and older than in those younger than 51 years. | 21700104 |
| Cataract | Deregulated Nutrient Sensing | A significant correlation was also found between a higher N, C, and P cataract score and lower expression of SirT1 in patients with age-related cataract (P < .001). | 21700104 |
| Cataract | Deregulated Nutrient Sensing | The decreased expression of SirT1 in the lens epithelium was associated with higher cataract scores and patient age. | 21700104 |
| Cataract | Deregulated Nutrient Sensing | The results suggest that a local SirT1 decrease in cataractous lens could be a risk factor for the initiation of age-related cataract formation. | 21700104 |
| Arterial Stiffness, Dyslipidemias | Deregulated Nutrient Sensing | EPA may reduce oxidative stress and inhibit the progression of arterial stiffness more efficiently than statin-only therapy in patients with dyslipidemia and CAD. | 21701083 |
| Pliability | Deregulated Nutrient Sensing | Transcriptional metabolic inflexibility in skeletal muscle among individuals with increasing insulin resistance. | 21701566 |
| Dyslipidemias | Deregulated Nutrient Sensing | It was concluded that dyslipidemia is common in all diabetics. | 21702294 |
| Demographics Domain, Cerebral Infarction, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Diabetes mellitus (DM), dyslipidemia, coronary artery disease (CAD), and chronic kidney disease (CKD), as well as symptomatic cerebral infarction and WML, were more frequent in patients with Fontaine III/IV PAD than without PAD. | 21703877 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Among the clinical variables, dyslipidemia (OR 5.3; CI 95% 1.3-20.9; p=0.016), coronary artery disease (OR 4.2; CI 95% 1.3-13.3; p=0.014) and a positive stress echo response (OR 9.0; CI 95% 1.7-49.1; p=0.011) were independently associated with the occurrence of a cardiovascular event. | 21705097 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | A positive stress echo response, the presence of coronary artery disease, and dyslipidemia positively predicted the occurrence of cardiovascular events. | 21705097 |
| BDI - Functional Impairment | Deregulated Nutrient Sensing | Endocrine functional impairment with insulin resistance was found in patients after AP. | 21705952 |
| glycation, Diabetes Mellitus | Deregulated Nutrient Sensing | Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1. | 21709297 |
| diabetic | Deregulated Nutrient Sensing | Because basal OS in type 2 diabetic patients is influenced by the consumption of AGEs, we examined whether AGE consumption also affects IR and whether AGER1 and SIRT1 are involved. | 21709297 |
| Tumor necrosis, diabetic | Deregulated Nutrient Sensing | Insulin and homeostasis model assessment, leptin, tumor necrosis factor-a and nuclear factor-kB p65 acetylation, serum AGEs, and 8-isoprostanes decreased in AGE-restricted type 2 diabetic patients, whereas PMNC AGER1 and SIRT1 mRNA, and protein levels normalized and adiponectin markedly increased. | 21709297 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Food-derived pro-oxidant AGEs may contribute to IR in clinical type 2 diabetes and suppress protective mechanisms, AGER1 and SIRT1. | 21709297 |
| Dyslipidemias | Deregulated Nutrient Sensing | Undernutrition (diminished lean body mass, risk of magnesium and vitamin deficiencies) contrasted with dyslipidemia and increased cardiovascular risk. | 21709952 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Most reported having arterial hypertension, dyslipidemia, a sedentary lifestyle, and had quit smoking and drinking. | 21710067 |
| Polycystic Ovary Syndrome, Overweight | Deregulated Nutrient Sensing | The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome. | 21711376 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Vitamin D and parathyroid hormone in insulin resistance of abdominal obesity: cause or effect? | 21712836 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Mixed dyslipidemia, oxidative stress and inflammation are related to a high risk for cardiovascular events. | 21714585 |
| Dyslipidemias | Deregulated Nutrient Sensing | The greater non-HDL-C- and LDL-C-lowering efficiency of rosuvastatin monotherapy along with its more potent effect on LpPLA2 activity and hsCRP levels indicate that this regimen is a better treatment option for patients with mixed dyslipidemia. | 21714585 |
| Liver diseases, Neuropathy, Dyslipidemias, Intervertebral Disk Displacement, Heart Diseases, Diabetes Mellitus, Kidney Diseases, Hypertension, CTCAE, Hematological Disease, Arteriopathic disease | Deregulated Nutrient Sensing | We detected subjects suffering from diabetes mellitus, kidney diseases, heart diseases, disk herniation, neuropathy, blood diseases, liver diseases, artery diseases, dyslipidemia, or hypertension. | 21718253 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association between insulin resistance and lean mass loss and fat mass gain in older men without diabetes mellitus. | 21718263 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To examine the associations between insulin resistance and changes in body composition in older men without diabetes mellitus. | 21718263 |
| Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | smoking, overweight or obese, hypertension, dyslipidaemia, or hyperglycaemia) was 31.17, 27.38, 17.76, and 10.19%, respectively. | 21719451 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Recent studies have demonstrated that mammalian sirtuin 1 (SIRT1), a histone deacetylase, is an exciting target for cardiovascular disease management. | 21719763 |
| Muscle, Smooth, Vascular, Calcinosis | Deregulated Nutrient Sensing | Here, we investigated the role of SIRT1 in a calcification model of vascular smooth muscle cells (SMCs). | 21719763 |
| Calcinosis | Deregulated Nutrient Sensing | Activation of SIRT1 by resveratrol significantly reduced the senescence-associated calcification. | 21719763 |
| Calcinosis | Deregulated Nutrient Sensing | Conversely, SIRT1 knockdown by small interfering RNA accelerated the Pi-induced SMC senescence and subsequent calcification. | 21719763 |
| Arterial calcification | Deregulated Nutrient Sensing | SIRT1 plays an essential role in preventing hyperphosphatemia-induced arterial calcification via inhibition of osteoblastic transdifferentiation. | 21719763 |
| Muscle, Smooth, Vascular | Deregulated Nutrient Sensing | Sirtuin 1 retards hyperphosphatemia-induced calcification of vascular smooth muscle cells. | 21719763 |
| Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cerebrovascular accident | Deregulated Nutrient Sensing | Statin users were older age, and had higher frequencies of dyslipidemia, diabetes mellitus, atrial fibrillation, prior stroke history and large HV compared to non-users. | 21720057 |
| Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Particularly CHD patients with obesity, diabetes, and dyslipidaemia need better management and control of elevated blood pressure. | 21720270 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Liver attenuation, pericardial adipose tissue, obesity, and insulin resistance: the Multi-Ethnic Study of Atherosclerosis (MESA). | 21720430 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Insulin resistance is linked to general and abdominal obesity, but its relation to hepatic lipid content and pericardial adipose tissue is less clear. | 21720430 |
| Vascular Diseases, Cardiomyopathies, Cardiovascular Diseases, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Heart failure, Kidney Diseases, Hypertension, CTCAE, Cardiac Arrhythmia | Deregulated Nutrient Sensing | Recipients also had an increased cumulative incidence of ischemic heart disease, cardiomyopathy or heart failure, stroke, vascular diseases, and rhythm disorders and an increased incidence of related conditions that predispose toward more serious cardiovascular disease (hypertension, renal disease, dyslipidemia, and diabetes). | 21727290 |
| Fibrosis Assessment, Fatty degeneration, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance, steatosis, and fibrosis in Egyptian patients with chronic Hepatitis C virus infection. | 21727730 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance has an important role in the pathogenesis of steatosis, which represents a significant determinant of fibrosis together with high serum AST level and older age. | 21727730 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidemia was reversed in children who recovered from obesity. | 21727757 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | No difference in other risk factors, for example, hypertension, dyslipidemia and smoking, was detected. | 21728271 |
| Malabsorption Syndrome, Dyslipidemias, Primary Biliary Cholangitis, Osteoporosis | Deregulated Nutrient Sensing | Concomitant to the primary biliary cirrhosis hypothyroidism, osteoporosis, malabsorption and dyslipidemia can occur. | 21732301 |
| Dyslipidemias, Brain hemorrhage, Diabetes Mellitus, Insulin-Dependent, Rheumatoid Arthritis, Ischemic stroke, Hypertension, CTCAE | Deregulated Nutrient Sensing | HRs were similar for ischemic stroke and brain hemorrhage and were not affected by adjustment for type 1 diabetes, rheumatoid arthritis, use of medication against hypertension, or dyslipidemia. | 21733721 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low birth weight is associated with type 2 diabetes, which to some extent may be mediated via abdominal adiposity and insulin resistance. | 21733994 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease markers are associated with insulin resistance in type 1 diabetes. | 21735081 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin resistance. | 21735081 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | To explore the relationship between markers of NAFLD, namely concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALK), g-glutamyltransferase (GGT), ferritin and bilirubin and insulin resistance in type 1 diabetes. | 21735081 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Correlations and multiple logistic regressions analysis were performed to identify the relationships between NAFLD associated markers and eGDR, individual components of insulin resistance and risk of insulin resistance. | 21735081 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In a multiple logistic regression model adjusted according to age, sex, duration of diabetes and BMI, increased levels of AST, ALT and ALK resulted in an increased risk for the development of insulin resistance in our subjects (OR = 1.03, 1.02, and 1.01, respectively; all P < 0.05). | 21735081 |
| Systemic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | These findings indicate that higher levels of ALT, AST and ALK are additional markers of insulin resistance in type 1 diabetes and suggest that those subjects must be considered as potentially affected not only by a hepatic but also by a multisystemic disease through altered insulin sensitivity. | 21735081 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The control and treatment of dyslipidemia is a major public health challenge, particularly for patients with coronary heart diseases. | 21735134 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Moreover, hypertensive patients showed an altered glucose response to stress, as indicated by higher admission glucose values, poorer in-hospital glucose control, and a higher incidence of acute insulin resistance (as indicated by the HOMA index). | 21735205 |
| Prostate Cancer Outcomes Study, Hyperandrogenism, Polycystic Ovary Syndrome, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and oligo-/anovulation and is associated with risk factors for cardiovascular disorders, such as insulin resistance and central adiposity. | 21735693 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia in patients with transient ischemic attack. | 21737806 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | There is mounting evidence that atherogenic dyslipidemia (ie, low high-density lipoprotein cholesterol combined with high triglyceride concentrations) is an independent predictor of high cardiovascular risk and possibly of stroke. | 21737806 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia was defined as high-density lipoprotein cholesterol blood concentration <= 40 mg/dL and triglycerides >= 150 mg/dL. | 21737806 |
| Dyslipidemias, Tacca leontopetaloides, Cerebral Ischemia, Cerebrovascular accident | Deregulated Nutrient Sensing | Among 1471 consecutive patients with transient ischemic attack (TIA) or minor stroke, overall prevalence of atherogenic dyslipidemia was 5.8%, but varied from 4.6% to 11.1%, depending on final diagnosis (possible TIA or TIA with a cerebral ischemic lesion, respectively). | 21737806 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prevalence of atherogenic dyslipidemia was independently associated with male sex, diabetes, and body mass index, but not with ABCD2 score. | 21737806 |
| Extracranial, Dyslipidemias, Intracranial | Deregulated Nutrient Sensing | Atherogenic dyslipidemia also strongly associated with symptomatic intracranial stenosis >= 50% (adjusted odds ratio, 2.77; 95% CI, 1.38-5.55), but not with symptomatic extracranial stenosis >= 50% (adjusted odds ratio, 1.20; 95% CI, 0.64-2.26). | 21737806 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Despite appropriate secondary prevention treatment, 90-day stroke risk was greater in patients with versus without atherogenic dyslipidemia (4.8% versus 1.7%; P=0.04). | 21737806 |
| Tacca leontopetaloides, Dyslipidemias, Cerebrovascular accident, Structure of intracranial artery | Deregulated Nutrient Sensing | The atherogenic dyslipidemia phenotype in patients with TIA may be associated with intracranial artery stenosis and higher risk of early recurrent stroke. | 21737806 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Subjects with VFA and WC above these cutoff values exhibited increased insulin resistance and increased carotid intima-media thickness. | 21738344 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis. | 21739426 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | To investigate the correlation between serum visfatin and insulin resistance (IR) in non-diabetic essential hypertensive (EH) patients with and without IR, and to evaluate the effect of antihypertensive treatment on serum visfatin and IR in these patients. | 21742399 |
| Hyperthyroidism | Deregulated Nutrient Sensing | To investigate ghrelin and resistin concentrations in patients with hyperthyroidism before and after restoration to a euthyroid state and to correlate the 2 peptides with anthropometric and insulin resistance parameters. | 21742599 |
| Hyperthyroidism | Deregulated Nutrient Sensing | In hyperthyroid patients, serum resistin levels and insulin resistance parameters were higher and plasma ghrelin levels were lower than in control participants (P<.001), and all normalized after treatment. | 21742599 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. | 21742641 |
| Refractory anemias, Rheumatoid Arthritis, Inflammation | Deregulated Nutrient Sensing | To analyse the expression of SIRT1 in synovial tissues and cells of patients with rheumatoid arthritis (RA) and to study the function of SIRT1 in inflammation and apoptosis in RA. | 21742641 |
| Refractory anemias, Tumor necrosis | Deregulated Nutrient Sensing | Levels of SIRT1 expression were analysed in synovial tissues and cells from patients with RA by real-time PCR and western blotting before and after stimulation with toll-like receptor ligands, tumour necrosis factor a (TNFa) and interleukin 1b (IL-1b). | 21742641 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Peripheral blood monocytes and rheumatoid arthritis synovial fibroblasts (RASFs) were transfected with wild-type or enzymatically inactive SIRT1 expression vectors or with siRNA targeting SIRT1. | 21742641 |
| Refractory anemias | Deregulated Nutrient Sensing | Cytokine analysis of IL-6, IL-8 and TNFa were performed by ELISA to study the role of SIRT1 on proinflammatory mediators of RA. | 21742641 |
| Refractory anemias, Degenerative polyarthritis | Deregulated Nutrient Sensing | SIRT1 was found to be constitutively upregulated in synovial tissues and cells from patients with RA compared to osteoarthritis. | 21742641 |
| Dyslipidemias | Deregulated Nutrient Sensing | We conclude that dyslipidemia, which increases the risk of CVD by increasing atherogenesis, progresses over time in dialysis patients and becomes worse in CAPD patients. | 21743212 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In patients with hypertension and obesity showing insulin resistance, treatment with telmisartan significantly improved the hyperinsulin response to glucose loading. | 21744143 |
| Dyslipidemias, Hypothyroidism, Coronary heart disease, Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypothyroidism is associated with an increase in a number of coronary heart disease (CHD) risk factors including dyslipidemia, hypertension, and elevated levels of homocysteine. | 21745107 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Recently, it has been shown that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC) and liver fibrosis independent of visceral adiposity and insulin resistance. | 21745307 |
| Impaired cognition, Data types - Address | Deregulated Nutrient Sensing | While insulin resistance is associated with cognitive decline in nondemented aging, higher peripheral insulin may have AD-specific benefits or insulin signaling may be affected by systemic physiologic changes associated with AD. | 21745566 |
| Heart failure, Neoplasms | Deregulated Nutrient Sensing | The tumor suppressor p53 has been implicated in the pathogenesis of non-cancer-related conditions such as insulin resistance, cardiac failure, and early aging. | 21747166 |
| Neoplasms | Deregulated Nutrient Sensing | Our findings demonstrate that GAPDH depletion switches human tumor cells to senescent phenotype via AMPK network, in the absence of DNA damage. | 21749859 |
| Heart Diseases, One Vessel Coronary Disease, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Risk factors like dyslipidemia, hypertension, previous history of heart disease and triple vessel disease were found more in group A than in group B. | 21751588 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | This study evaluated 181 overweight men and women with mixed dyslipidemia. | 21752880 |
| Hepatocarcinogenesis | Deregulated Nutrient Sensing | Insulin resistance plays a role in hepatocarcinogenesis and is decreased by metformin treatment. | 21752887 |
| Metabolic Diseases, Overnutrition, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity is the most relevant overnutrition disease worldwide and is associated to different metabolic disorders such as insulin resistance and type-2 diabetes. | 21756320 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular disease prevention for patients with type 2 diabetes is accomplished through hypertension and dyslipidemia management. | 21775166 |
| Overweight | Deregulated Nutrient Sensing | In overweight and obese women, insulin resistance is associated with increased MTG content, cardiac remodelling and reduced diastolic function. | 21775510 |
| Obesity | Deregulated Nutrient Sensing | Apelin, which is a newly identified adipokine, is related to obesity and insulin resistance. | 21775567 |
| Obesity | Deregulated Nutrient Sensing | We treated the primary adipocytes with high glucose plus insulin because of a close relation between insulin resistance and obesity. | 21775567 |
| Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response Terminology | Deregulated Nutrient Sensing | In addition to traditional risk factors, insulin resistance was associated with an increased risk of DR in Koreans with type 2 diabetes. | 21775765 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of hypertension, impaired glucose tolerance (IGT), diabetes mellitus (DM), dyslipidemia and obesity in our SCS cases were 56%, 50%, 50%, and 19%, respectively, and 75% of cases were associated with two or more cardiovascular risk factors. | 21775997 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In terms of differential changes in risk factors between the groups, more significant improvements of hypertension, dyslipidemia and IGT/DM were observed in the OP group than in the non-OP group. | 21775997 |
| TG gene, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | In conclusion, dyslipidemia, using serum TG and TG/HDL-C, in particular, may be useful in identification of women at risk of hypertension, even in those without diabetes and central or general obesity. | 21776016 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Mediterranean diet improves dyslipidemia and biomarkers in chronic renal failure patients. | 21776461 |
| Inflammation, Cardiovascular Diseases, Cancer-related fatigue, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia, oxidative stress (OS) and inflammation increase the risk of cardiovascular disease in chronic renal failure (CRF) patients. | 21776461 |
| Cardiovascular event, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Statins are widely prescribed drugs in the United States for the management of dyslipidemia, atherosclerosis, and cardiovascular event risk reduction. | 21777752 |
| Prediabetes syndrome, muscle mass | Deregulated Nutrient Sensing | Relative muscle mass is inversely associated with insulin resistance and prediabetes. | 21778224 |
| Low muscle mass, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, the basis of type 2 diabetes, is rapidly increasing in prevalence; very low muscle mass is a risk factor for insulin resistance. | 21778224 |
| Hyperlipidemia, Hypertension, CTCAE, Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | More than 80% of patients entering cardiac rehabilitation are overweight, with a high prevalence of associated insulin resistance, diabetes, hypertension, hyperlipidemia, and a prothrombotic state. | 21778256 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. | 21778425 |
| diabetic | Deregulated Nutrient Sensing | Moreover, compared to streptozotocin-induced wild-type diabetic mice, endothelium-specific SIRT1 transgenic diabetic mice had decreased p66Shc expression at both the mRNA and the protein levels, improved endothelial function, and reduced accumulation of nitrotyrosine and 8-OHdG (markers of oxidative stress). | 21778425 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Our findings indicate that repression of p66Shc expression by SIRT1 contributes to the protection of hyperglycemia-induced endothelial dysfunction. | 21778425 |
| Dyslipidemias | Deregulated Nutrient Sensing | In particular, in postmenopausal women the increase in content of total cholesterol, triglycerides, LDL and fibrinogen, the decrease in HDL take place that leads to estrogen-dependent dyslipidemia. | 21778553 |
| Blood Glucose | Deregulated Nutrient Sensing | Muscular PDE concentrations associate with age, lower resting mitochondrial activity and insulin resistance, which is determined mainly by body mass and glycemia. | 21779337 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustment for sex, smoking, diabetes, dyslipidemia, BMI, triglycerides and DD, TT and CC genotypes, BMI was independent risk factor of HTA (OR = 3.14; P < 0.001). | 21779803 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | (2) The prevalence of with at least one cardiovascular risk factor was 78.00% in this cohort, the top there risk factors were dyslipidemia (61.06%), hypertension (44.59%) and diabetes (13.80%). | 21781604 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | CKD and hypertension were independent determinants of arteriolar narrowing after adjusting for age, gender, diabetes, dyslipidemia, and smoking history. | 21784828 |
| Dyslipidemias | Deregulated Nutrient Sensing | Furthermore, gender differences in the association between dyslipidaemia and outcome of DKD are largely unknown. | 21785041 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | He also had visual field defect, uncontrolled diabetes, and dyslipidemia. | 21785175 |
| Dental Plaque | Deregulated Nutrient Sensing | The total coronary plaque burden (TCPB) was 3.45 +- 1.02 cm(3)/patient and had a positive correlation with waist circumference (r =0.44, p < 0.05) and insulin resistance (r = 0.46, p < 0.05). | 21785228 |
| NRAS gene | Deregulated Nutrient Sensing | Several cancer-associated genes were involved, including gain of BCL2L1, ARTN, AMPK, NRAS, and CCNA1 and loss of IGF2, CDKN1C, PAX6, WT1, TRAF6, MAPK8IP1, and IMP3. | 21785329 |
| Atherosclerosis | Deregulated Nutrient Sensing | Cross-sectional and longitudinal changes of glucose effectiveness in relation to glucose tolerance: the insulin resistance atherosclerosis study. | 21788626 |
| Dyslipidemias | Deregulated Nutrient Sensing | Altered serum selenium and uric acid levels and dyslipidemia in hemodialysis patients could be associated with enhanced cardiovascular risk. | 21789541 |
| Dyslipidemias | Deregulated Nutrient Sensing | HPs showed a marked dyslipidemia, with a significant reduction in total cholesterol, low-density lipoprotein, and high-density lipoprotein cholesterol levels and a significant increase in triglyceride levels (p < 0.001). | 21789541 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | The marked dyslipidemia and hyperuricemia found in HPs and the negative correlation between the serum Se and uric acid levels in these patients could imply an enhanced cardiovascular risk. | 21789541 |
| Calcification of coronary artery, Atherosclerosis | Deregulated Nutrient Sensing | The relationship of insulin resistance and extracoronary calcification in the multi-ethnic study of atherosclerosis. | 21798541 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Results indicate that Lingzhi might have mild antidiabetic effects and potentially improve the dyslipidaemia of diabetes, as shown previously in some animal studies. | 21801467 |
| Overweight | Deregulated Nutrient Sensing | Relationship of insulin resistance to psychobehavioral characteristics of overweight and obese African American children. | 21801736 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | This study performed to determine the effects of folate supplementation on indices of glycemic control, insulin resistance and lipid profile in overweight and obese men with type 2 diabetes under metformin (at least 1500 mg daily) treatment. | 21802161 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Folic acid supplementation lowered plasma level of homocysteine, improved glycemic control and insulin resistance in patients with type 2 diabetes. | 21802161 |
| Obesity | Deregulated Nutrient Sensing | The association with obesity and insulin resistance is well established. | 21803757 |
| Chronic Periodontitis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis. | 21804283 |
| Dyslipidemias, Restless Legs Syndrome | Deregulated Nutrient Sensing | That is, patients with RLS have lower quality of sleep and dyslipidemia compared to persons without RLS. | 21804343 |
| Weight Gain, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Second-generation antipsychotics (SGAs) tend to induce weight gain, dyslipidemia and diabetes mellitus. | 21807061 |
| CX drug brand name, Dyslipidemias, Family history | Deregulated Nutrient Sensing | The presence of CAP was higher in patients with FH of premature CAD in LAD and Cx compared to patients without FH of premature CAD (70.8% vs 58.0%, p=0.013 for LAD; 42.3% vs 30.4%, p=0.021 for Cx; 34.5% vs 29.8%, p=0.348 for RCA).In multinominal logistic regression analysis age, male gender, dyslipidemia and FH of premature CAD seemed significant predictors of primarily noncalcified CAP(OR:1.17, 95% CI:1.07-1.15, p<0.001; OR:0.19, 95% CI:0.09-0.38, p<0.001; OR:2.26, 95% CI:1.21-4.24, p=0.01; OR:3.32, 95% CI:1.74-6.34, p<0.001 respectively) after adjustment for other risk factors. | 21807431 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Baseline clinical characteristics were similar with hypertension in 146 (78%), dyslipidemia in 85 (45.5%) and diabetes in 68 (36.4%). | 21808863 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To compare the long-term efficacy and safety of pitavastatin with atorvastatin in patients with type 2 diabetes and combined (mixed) dyslipidaemia. | 21812889 |
| Impaired cognition, Diabetes Mellitus | Deregulated Nutrient Sensing | AMPK g2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age. | 21813245 |
| Obesity | Deregulated Nutrient Sensing | Increased serum resistin was found in rodent models of obesity and insulin resistance, whereas contradictory results have been obtained in human studies. | 21813294 |
| Chronic liver disease, Non-alcoholic Fatty Liver Disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is associated with insulin resistance and cardiovascular disease. | 21816784 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Our objective was to examine the relationship between NAFLD and IGF-I levels and to test the hypothesis that free fatty acids-induced insulin resistance might impair insulin-induced increase of GH receptor (GHR) expression in human hepatoma cells. | 21816784 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These data show that IGF-I levels are reduced in subjects with NAFLD and suggest that hepatic insulin resistance may affect IGF-I levels by modulating GH-stimulated synthesis of hepatic IGF-I. | 21816784 |
| Microalbuminuria, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The patients with CKD were older, had had diabetes mellitus longer, and had higher incidence of hypertension, dyslipidemia and microalbuminuria than those without. | 21817822 |
| Chronic disease | Deregulated Nutrient Sensing | These data suggest that differences in lipid and lipoprotein concentrations, liver function, and insulin resistance may explain why the risks of chronic disease are lower in men who are fat and fit than those who are fat and unfit. | 21820133 |
| Gout, Dyslipidemias, Prostate carcinoma, Diabetes Mellitus, Breast Carcinoma, Malignant Neoplasms, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most common cancers were liver, colon, lung, breast, and prostate cancer; and except for breast cancer, their incidences increased independently of hypertension, dyslipidemia, and gout in patients with diabetes. | 21820134 |
| Chronic disease | Deregulated Nutrient Sensing | These data underscore the need for a better understanding of postprandial fatty acid oxidation and dietary fat delivery in the setting of adipose insulin resistance to determine how postprandial lipemia contributes to chronic disease risk. | 21820684 |
| Polycystic Ovary Syndrome, Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Diseases | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) and type 2 diabetes (T2D) are two common metabolic disorders in reproductive-aged women, and both are associated with insulin resistance. | 21820924 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Racial and geographic differences in prevalence, awareness, treatment and control of dyslipidemia: the reasons for geographic and racial differences in stroke (REGARDS) study. | 21822024 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Racial and geographic differences in dyslipidemia prevalence, awareness, treatment and control may, in part, account for the observed disparities in stroke mortality. | 21822024 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Racial, but not geographic, differences in dyslipidemia management may play a role in the excess stroke burden in the Southeast. | 21822024 |
| macroangiopathy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy. | 21822540 |
| macroangiopathy, Diabetes Mellitus, Non-Insulin-Dependent, Yin Deficiency | Deregulated Nutrient Sensing | To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficiency of yin, Qi-Yin deficiency, and Yin-Yang deficiency, according to the TCM syndromes, with a control group of 20 healthy individuals. | 21822540 |
| Yin Deficiency | Deregulated Nutrient Sensing | Insulin resistance plays an important role in the occurrence of T2DM macroangiopathy and is closely associated with the Yin-Yang deficiency according to the TCM differentiating types. | 21822540 |
| Toxic effect | Deregulated Nutrient Sensing | Corticosteroids induce insulin resistance and present a risk to islet autografts, through glucotoxicity and increased metabolic demand on a marginal islet mass. | 21822910 |
| Heart failure | Deregulated Nutrient Sensing | AMP activated protein kinase-a2 regulates expression of estrogen-related receptor-a, a metabolic transcription factor related to heart failure development. | 21825219 |
| Lipodystrophy | Deregulated Nutrient Sensing | Lipodystrophy, insulin resistance, and adiponectin concentration in HIV-infected children and adolescents. | 21827385 |
| Metabolic Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Alterations of fat distribution and insulin resistance are associated with increased risk of metabolic derangements and cardiovascular disease. | 21827385 |
| Lipodystrophy, Hypoadiponectinemia | Deregulated Nutrient Sensing | HIV-infected adult patients on antiretroviral treatment often show lipodystrophy, insulin resistance and hypoadiponectinemia, but data in children are controversial. | 21827385 |
| Lipohypertrophy, CTCAE | Deregulated Nutrient Sensing | Low adiponectin concentration is associated to central fat and mixed lipohypertrophy, and to signs of insulin resistance in HIV-infected youths. | 21827385 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia is increasing in many parts of Brazil, but it is yet unclear how much exercise is needed to attain beneficial effects on plasma lipoprotein levels. | 21830000 |
| Dyslipidemias, Sao Paulo | Deregulated Nutrient Sensing | The study analyzed eight cities of the state of Sao Paulo, the association between the continued practice of physical exercise throughout life and the occurrence of dyslipidemia in adulthood. | 21830000 |
| Dyslipidemias | Deregulated Nutrient Sensing | Women (p = 0.001) and obese individuals (p = 0.001) had a higher rate of dyslipidemia. | 21830000 |
| Dyslipidemias | Deregulated Nutrient Sensing | Physically active adults in all three stages of life were 65% less likely to report dyslipidemia (OR = 0.35 [0.15 to 0.78]). | 21830000 |
| Dyslipidemias | Deregulated Nutrient Sensing | The continued practice of physical exercise throughout life was associated with a lower incidence of dyslipidemia in adults in the State of Sao Paulo. | 21830000 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The association of bone density and calcified atherosclerosis is stronger in women without dyslipidemia: the multi-ethnic study of atherosclerosis. | 21834088 |
| SLC25A20 gene, Dyslipidemias | Deregulated Nutrient Sensing | The inverse association of BMD with CAC is stronger in women without dyslipidemia. | 21834088 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | These data argue against the hypothesis that dyslipidemia is the key factor responsible for the inverse association of BMD with atherosclerosis. | 21834088 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Recipient characteristics associated therewith were higher body mass index (P = .000), smoking habit (P = .003), ischemic cardiopathy (P = .01), and dyslipidemia (P = .05). | 21839224 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Acanthosis nigricans is a hyperkeratotic lesion of the epidermis associated with insulin resistance. | 21839533 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The Finnish Diabetes Risk Score is associated with insulin resistance but not reduced b-cell function, by classical and model-based estimates. | 21843304 |
| Nonalcoholic Steatohepatitis, Hepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease associated with insulin resistance and its metabolic consequences. | 21845516 |
| Gestational Diabetes, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Gestational diabetes mellitus (GDM), a state of glucose intolerance associated with pregnancy, is increasing in prevalence. | 21847538 |
| Inflammation, Infection, Diabetes Mellitus | Deregulated Nutrient Sensing | Likewise, chronic inflammation or infections seem to provoke insulin resistance and thereby contribute to the development of diabetes and its complications. | 21848608 |
| Gastroesophageal reflux disease | Deregulated Nutrient Sensing | Increasing insulin resistance is associated with increased severity and prevalence of gastro-oesophageal reflux disease. | 21848629 |
| Inflammation | Deregulated Nutrient Sensing | Six-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice. | 21849520 |
| Steatohepatitis, Inflammation, Meibomian gland dysfunction | Deregulated Nutrient Sensing | Increased visceral fat, as opposed to subcutaneous/gluteal, most strongly relates to key metabolic dysfunctions including insulin resistance, hepatic steatosis, and inflammation. | 21852815 |
| Prostate Cancer Outcomes Study, Hyperandrogenism, Polycystic Ovary Syndrome, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo/anovulation and is associated with risk factors for cardiovascular diseases, such as insulin resistance and central adiposity. | 21853932 |
| Hypertension, CTCAE, Retinal Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension (p < 0.05), suboptimal glycaemic control (p < 0.05) and long diabetes duration (p < 0.05) were associated with risk of retinopathy whilst lower age of diagnosis and dyslipidaemia were not significant predictive factors. | 21855159 |
| Lipodystrophy | Deregulated Nutrient Sensing | Among patients receiving HAART, those with lipodystrophy had a greater degree of insulin resistance, higher triglyceride levels, and lower levels of high-density lipoprotein cholesterol. | 21856599 |
| Arterial Stiffness, Dyslipidemias | Deregulated Nutrient Sensing | Low-dose rosuvastatin would be more effective than fluvastatin in improving arterial stiffness in high-risk Japanese patients with dyslipidemia. | 21857142 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. | 21858147 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Notably, sex-biased genes are enriched at loci associated with polygenic dyslipidemia and coronary artery disease in genome-wide association studies. | 21858147 |
| diabetic | Deregulated Nutrient Sensing | The expression of a protein deacetylase that targets Foxo4 for deacetylation, sirtuin (Sirt1), is down regulated in cultured podocytes by AGE-BSA treatment and in glomeruli of diabetic patients. | 21858169 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Together, our data provide evidence that alteration of Foxo4 acetylation and down regulation of Sirt1 expression in diabetes promote podocyte apoptosis. | 21858169 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Strategies to preserve Sirt1 expression or reduce Foxo4 acetylation could be used to prevent podocyte loss in diabetes. | 21858169 |
| Diabetic Nephropathy, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Prevalence of dyslipidemia among adult diabetic patients with overt diabetic nephropathy in Anambra state south-east Nigeria. | 21860134 |
| Diabetic Nephropathy, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia has been identified as a risk factor for the development and progression of diabetic renal disease. | 21860134 |
| Dyslipidemias, Kidney Diseases, diabetic | Deregulated Nutrient Sensing | This study was done to determine the prevalence of dyslipidemia among diabetic patients with overt nephropathy. | 21860134 |
| Diabetic Nephropathy, Dyslipidemias, Kidney Failure, Chronic, diabetic | Deregulated Nutrient Sensing | Diabetic patients with overt diabetic nephropathy have significant dyslipidemia and aggressive lipid lowering in these patients may retard their progression to end-stage renal disease. | 21860134 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Contribution of insulin deficiency and insulin resistance to the development of type 2 diabetes: nature of early stage diabetes. | 21861172 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | At the time of diagnosis of type 2 diabetes (T2D), patients already have varying degrees of beta-cell dysfunction and insulin resistance and the defects continue to deteriorate despite treatment. | 21861172 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | We examined insulin secretion impairment and insulin resistance in overweight patients with T2D who had metformin failure, with elevated HbA1c at maximal metformin dose. | 21861172 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | Metformin failure in these patients was associated with beta-cell dysfunction to a greater extent than insulin resistance. | 21861172 |
| Inflammation, Endothelial dysfunction, diabetic | Deregulated Nutrient Sensing | We assessed whether cardiovascular risk factors including more novel factors such as markers of insulin resistance, inflammation, activated coagulation and endothelial dysfunction differ more between diabetic and non-diabetic women than between diabetic and non-diabetic men, and the role of insulin resistance. | 21861177 |
| diabetic, Diabetes Mellitus | Deregulated Nutrient Sensing | Levels of waist circumference, BMI, von Willebrand factor (VWF), WBC count, insulin resistance (HOMA-IR), diastolic blood pressure, HDL-cholesterol, tissue plasminogen activator (t-PA) and factor VIII differed more between diabetic and non-diabetic women than between diabetic and non-diabetic men (test for diabetes x sex interaction p < 0.05). | 21861177 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The more adverse effect of diabetes on these risk markers in women was associated with, and thereby largely attenuated by, insulin resistance. | 21861177 |
| Dyslipidemias, Psychiatric | Deregulated Nutrient Sensing | Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients. | 21861666 |
| Dyslipidemias, Hypertension, CTCAE, Atherosclerosis | Deregulated Nutrient Sensing | Common atherosclerosis risk factors were dyslipidemia (80.2%), hypertension (71.8%) and smoking (40.7%). | 21863674 |
| Obesity | Deregulated Nutrient Sensing | Our objective was to determine whether regional fat distribution, independent of obesity, is associated with insulin resistance. | 21865361 |
| Hyperglycemia, Dyslipidemias, Cerebrovascular accident, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The Western dietary patterns also association with high risk of stroke, which was largely mediated by obesity, hypertension, hyperglycemia, and dyslipidemia. | 21865562 |
| Hepatitis C | Deregulated Nutrient Sensing | Relation of serum insulin-like growth factor-1 (IGF-1) levels with hepatitis C virus infection and insulin resistance. | 21867981 |
| Hyperlipidemia, No metabolic abnormalities, Inflammation, Obesity | Deregulated Nutrient Sensing | In particular, no single agent can correct multiple metabolic abnormalities such as insulin resistance, hyperlipidemia, inflammation, obesity, and fat distribution. | 21869685 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The rate of resolution of diabetes, hypertension, and dyslipidemias were also similar with no statistical significance. | 21870050 |
| Obesity | Deregulated Nutrient Sensing | A lower exercise tolerance in elderly people without obesity can be considered not only as a risk factor for insulin resistance, but also as its consequence. | 21870513 |
| Dyslipidemias, Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | in these patients there was noticed a higher prevalence of dyslipidemias, obesity and depression in women. | 21870719 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). | 21874260 |
| Dyslipidemias, Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | In conclusion, changes in lipid variables and some hematological parameters may increase plasma viscosity as a step during atherosclerosis pathogenesis in male youth at risk for dyslipidemia and cardiovascular diseases. | 21874826 |
| Dyslipidemias | Deregulated Nutrient Sensing | We have shown its efficacy in correction of diabetic dyslipidemia, positive influence on clinical status and long term result of coronary intervention. | 21878080 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The MIG had twice the prevalence rate of diabetes as the LIG and higher prevalence rates of hypertension, obesity, and dyslipidemia. | 21880235 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Given that both insulin sensitivity and insulin resistance were found to be significant determinants of the difference between SBP and SBP2 in a healthy general population, we suggest measuring the SBP2 in individuals with impaired insulin action in order to accurately assess their risk of developing cardiovascular disease. | 21881525 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Also, the frequency of diabetes and dyslipidemia, and the plasma high sensitive C-reactive protein levels, were higher in the poor CCC group (P = 0.003, P = 0.018, P<0.001, respectively). | 21887692 |
| Premature coronary artery atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | There was a linear increase in the mean values of HOMA IR with increase in number of components of MS [p for trend < 0.001] Among Asian Indians who are known to have high risk of premature coronary artery disease and diabetes, a significant association exists between insulin resistance with cardiovascular risk factors even among NGT subjects. | 21887902 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Air pollution may promote type 2 diabetes by increasing adipose inflammation and insulin resistance. | 21888674 |
| Retinal Pigments, Personal Experience Inventory | Deregulated Nutrient Sensing | Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium. | 21890195 |
| Retinal Cone | Deregulated Nutrient Sensing | Importantly, PU-PEI-mediated Oct4/SirT1 gene transfer rescued retinal cell loss and improved electroretinographic responses in light-injured rat retinas. | 21890195 |
| Nonalcoholic Steatohepatitis, Biliary calculi | Deregulated Nutrient Sensing | Additionally, insulin resistance - linked to the development of non-alcoholic steatohepatitis - increases the risk of developing gallstones. | 21893698 |
| Obesity | Deregulated Nutrient Sensing | Ghsr ablation improves aging-associated obesity and insulin resistance by reducing adiposity and increasing thermogenesis. | 21895961 |
| Alzheimers Disease", glucose metabolism, Cognition Disorders, Data types - Address | Deregulated Nutrient Sensing | Glucose dysmetabolism has been consistently associated with an increased risk of cognitive disorders, and brain insulin resistance could play a role in Alzheimer's disease (AD) pathogenesis. | 21897007 |
| Atherosclerosis | Deregulated Nutrient Sensing | In this analysis we utilized existing data from the Insulin Resistance and Atherosclerosis Study (IRAS). | 21898383 |
| Fetal Growth Retardation | Deregulated Nutrient Sensing | Prior to the development of whole body insulin resistance, young men with IUGR are characterized by increased in vivo adipose tissue lipolysis and blood flow with a paradoxically decreased expression of lipases compared with CON, and 10 days of physical inactivity underlined the baseline findings. | 21903886 |
| Nodular glomerulosclerosis, Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Nodular glomerulosclerosis in a non-diabetic hypertensive smoker with dyslipidemia. | 21904413 |
| Dyslipidemias, diabetic, Obesity, Hypertension, CTCAE, Disease | Deregulated Nutrient Sensing | Diabetic patients were older and had higher prevalence of obesity, hypertension, dyslipidemia, and associated CV diseases than nondiabetic individuals (P<0.001). | 21905043 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension is associated with impaired glucose tolerance and insulin resistance. | 21906391 |
| Refractory anemias | Deregulated Nutrient Sensing | In patients with RA, cumulative GC dose was associated with T2DM, which seemed mostly driven by the effects of cumulative GC dose on insulin resistance; however, the association decreased when corrected for current disease activity. | 21908880 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. | 21909130 |
| Neoplasms | Deregulated Nutrient Sensing | Importantly, the demonstration that mTORC1 is an essential mediator of AKT-induced senescence raises the possibility that targeting mTORC1 in tumours with activated PI3K/AKT signalling may exert unexpected detrimental effects due to inactivation of a senescence brake on potential cancer-initiating cells. | 21909130 |
| Parapsoriasis en Plaques, Dyslipidemias | Deregulated Nutrient Sensing | The results of this study suggest that dyslipidemia increases the risk of plaque-type pathology. | 21911734 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), b-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes. | 21911752 |
| Ischemic stroke | Deregulated Nutrient Sensing | Insulin resistance is associated with a poor response to intravenous thrombolysis in acute ischemic stroke. | 21911778 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance (IR) may not only increase stroke risk, but could also contribute to aggravate stroke prognosis. | 21911778 |
| Obesity, Bipolar Disorder | Deregulated Nutrient Sensing | Longitudinal study of depressive symptoms and progression of insulin resistance in youth at risk for adult obesity. | 21911779 |
| Diabetes Mellitus, Non-Insulin-Dependent, Bipolar Disorder | Deregulated Nutrient Sensing | Research is needed to determine whether early intervention to decrease elevated depressive symptoms in youth ameliorates later development of insulin resistance and lessens the risk of type 2 diabetes. | 21911779 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, MS gene, Obesity | Deregulated Nutrient Sensing | Obesity is often associated with increased serum alanine aminotransferase (ALT), and elevation of ALT is a marker of non-alcoholic fatty liver disease which is caused in part by insulin resistance, the essential characteristic of metabolic syndrome (MS). | 21912108 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | Our findings suggest that hypoadiponectinemia is strongly associated with the risk of MS independent of insulin resistance. | 21912966 |
| Kidney Diseases | Deregulated Nutrient Sensing | Impact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients. | 21913955 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | 25(OH)D deficiency is associated with insulin resistance in CKD. | 21913955 |
| Atrial Fibrillation, Dyslipidemias, Atrial Fibrillation by ECG Finding, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, an important risk factor for cardiovascular disease, may be associated with atrial fibrillation (AF). | 21914959 |
| Demographics Domain, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The objective of this paper is to detect the incidence of insulin resistance (IR) in Chronic Kidney disease (CKD) patients and the presence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) in patients with/without IR. | 21917122 |
| Metabolic Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Carbohydrate metabolism disorder and insulin resistance are found in patients with CKD. | 21917122 |
| Hyperleucinemia, Inflammation, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Hyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men. | 21920718 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Twenty-one adults with poorly controlled type 2 diabetes and insulin resistance who were referred to the clinic between July 1, 2007, and June 30, 2008, and whose therapy was changed from large doses of U-100 insulin to U-500 insulin. | 21923457 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and visceral adiposity are predisposing factors for fatty liver disease. | 21923735 |
| Damage | Deregulated Nutrient Sensing | Insulin resistance (IR) contributes to the pathogenesis of impaired glucose tolerance and participates to the development of subclinical organ damage. | 21925746 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. | 21926268 |
| Diastolic blood pressure, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients in the SCH group had a higher proportion of women, older age, longer duration of diabetes, higher systolic and diastolic blood pressure, and higher insulin resistance index compared with the euthyroid group. | 21931224 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is associated with altered NF-kB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS. | 21931634 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | AMPK phosphorylation increased in volunteers with NGT, but not in those with diabetes. | 21931634 |
| Steatohepatitis, Hepatitis C | Deregulated Nutrient Sensing | Hepatic steatosis (HS) is highly prevalent in chronic hepatitis C and is an important variable predicting progression of histological injury, insulin resistance, and reduced response to antiviral therapy. | 21934202 |
| Obesity | Deregulated Nutrient Sensing | A distinct clustering of cardiometabolic responses supports the etiological importance of both overall and central obesity and insulin resistance in the modification of cardiometabolic risk in obese youths. | 21936669 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The mean values for HbA1c were higher in the diabetes (6.2%) and glucose intolerance groups (5.8%) than in the normal group (5.5%). | 21937392 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic inflammation contributes to insulin resistance and type 2 diabetes mellitus (T2DM). | 21938543 |
| Insulin Resistance, Obesity | Deregulated Nutrient Sensing | Altogether these data suggest that in conditions of insulin-resistance and obesity there is an up-regulation of myeloid DCs that might contribute to pathological vascular remodeling. | 21940050 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | To study the relationship between serum leptin and insulin resistance, and to analyze the effect of acupuncture on serum leptin level in patients with type-II diabetes mellitus (DM). | 21942183 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Persons who were more educated or who had dyslipidemia or diabetes were more likely than the others to report previous counseling. | 21943790 |
| Cardiovascular Diseases, Dyslipidemias, Damage, Hypertensive (finding), Chronic Kidney Diseases | Deregulated Nutrient Sensing | With respect to those with normal renal function, hypertensive women having CKD were older, showed higher values of blood pressure, and had more frequently dyslipidemia, elevated plasma glucose, target organ damage and cardiovascular disease (P<.001). | 21944650 |
| Carcinogenesis, Obesity | Deregulated Nutrient Sensing | Obesity, deregulation of adipocytokines, and insulin resistance are interrelated and have been implicated in carcinogenesis. | 21946019 |
| melanoma | Deregulated Nutrient Sensing | In search of novel risk factors for melanoma, we explored the association of this disease with insulin resistance in a small size, case-control study. | 21946019 |
| melanoma | Deregulated Nutrient Sensing | These findings point to insulin resistance as a potentially independent risk factor for melanoma and need to be confirmed by future larger studies, ideally allowing the control of the directionality of the association. | 21946019 |
| Lipolysis | Deregulated Nutrient Sensing | Lipid removal rate is positively correlated with the capacity of adipocytes to break down triglycerides, as assessed through lipolysis, and is inversely related to insulin resistance. | 21947005 |
| Hyperlipidemia, Dyslipidemias, Hereditary | Deregulated Nutrient Sensing | In contrast, both lipid removal and storage rates are decreased in non-obese patients diagnosed with the most common hereditary form of dyslipidaemia, familial combined hyperlipidaemia. | 21947005 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Persistent dyslipidemia in Austrian patients treated with statins for primary and secondary prevention of atherosclerotic events - Results of the DYSlipidemia International Study (DYSIS). | 21947362 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | When the subjects were divided into five groups (0-4) according to the number of metabolic factors (obesity, diabetes, hypertension and dyslipidemia), PEDF levels in patients with four factors were significantly higher than those in patients without factors. | 21947986 |
| Benign prostatic hypertrophy | Deregulated Nutrient Sensing | We evaluated the correlations between BMI, fasting glucose, insulin, testosterone level, insulin resistance, and prostate size in non-diabetic benign prostatic hyperplasia (BPH) patients with normal testosterone levels. | 21949470 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The patient had a history of hypertension and insulin resistance and had no history of alcohol abuse. | 21951092 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The progression of glucose intolerance from NGT to pre-T2DM and T2DM exhibits striking sex differences regarding the lipid profile. | 21951548 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia and the risk of incident hypertension in a population of community-dwelling Brazilian elderly: the Bambui Cohort Study of Aging. | 21952856 |
| Malignant tumor of exocrine pancreas, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Our data on HbA(1c) show that individuals who develop exocrine pancreatic cancer tend to have moderate increases in HbA(1c) levels, relatively independently of obesity and insulin resistance-the classic and major risk factors for type 2 diabetes. | 21953276 |
| Hypertensive (finding), Electrocardiogram: myocardial infarction (finding), Dyslipidemias | Deregulated Nutrient Sensing | Relationship of dyslipidemia and uric acid with the risk of myocardial infarction among hypertensive patients in Trinidad. | 21955256 |
| Hypertensive (finding), Electrocardiogram: myocardial infarction (finding), Dyslipidemias, diabetic | Deregulated Nutrient Sensing | To study the relationship of dyslipidemia and serum uric acid with the risk of myocardial infarction among the hypertensive type 2 diabetic and non-diabetic patients of Trinidad. | 21955256 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Hypertensive type 2 diabetics with dyslipidemia had greater occurrence of MI (23.93%) than non-diabetic hypertensive patients (7.67%) (p=0.008). | 21955256 |
| Hypertensive (finding), Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The results suggest that there is a greater prevalence of MI in hypertensive type 2 diabetic patients with dyslipidemia than in non-diabetic hypertensive patients in Trinidad. | 21955256 |
| Inflammation, ETV3 wt Allele | Deregulated Nutrient Sensing | MetS was found to be associated with markers of insulin resistance (IR), low-grade inflammation, and insufficient fibrinolysis. | 21955584 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hepatic FGF21 correlated inversely with hepatic AMPK phosphorylation In type 2 diabetes mellitus, combined pioglitazone and exenatide therapy is associated with a reduction in plasma FGF21 levels, as well as a greater decrease in hepatic fat than that achieved with pioglitazone therapy. | 21956711 |
| ovarian neoplasm | Deregulated Nutrient Sensing | Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC. | 21957481 |
| Dyslipidemias, Diabetic Foot, Coronary heart disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | In the GADA negative group obesity, coronary heart disease, hypertension, syndrome of diabetic foot and dyslipidaemia appeared more frequently (OR = 2.8; 3.1; 6.2 and 2.4). | 21957594 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The effect of quinapril treatment on insulin resistance, leptin and high sensitive C-reactive protein in hypertensive patients. | 21957896 |
| Arthritis, HIV Infections, Inflammatory polyarthritis | Deregulated Nutrient Sensing | Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study. | 21959060 |
| Refractory anemias, Rheumatoid Arthritis | Deregulated Nutrient Sensing | In established rheumatoid arthritis (RA), insulin resistance (IR) is increased and associated with CVD. | 21959060 |
| Weight decreased | Deregulated Nutrient Sensing | Dietary weight loss and exercise effects on insulin resistance in postmenopausal women. | 21961463 |
| Weight decreased | Deregulated Nutrient Sensing | Dietary weight loss, with or without exercise, significantly improved insulin resistance. | 21961463 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | We studied 3,484 older hypertensive patients with dyslipidemia in 6 primary care practices over a 4-year timeframe. | 21961563 |
| Prostate Cancer Outcomes Study, Disorder of endocrine ovary | Deregulated Nutrient Sensing | The PCOS phenotype changed with aging, suggesting an amelioration of the phenotype and ovarian dysfunction as indicated by the increase in number of regular menstrual cycles, decrease in serum androgen levels, and decrease in insulin resistance. | 21963227 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance (IR) has been directly related to obesity, particularly central obesity, and to other cardiovascular risk factors (CVRFs). | 21963533 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | In MetS subjects with high HDL-C levels, insulin resistance was increased. | 21963728 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Heavy smoking was significantly associated with T2DM, and this association was moderated by CYP2A6 genotype and mediated by serum cotinine, abdominal obesity, insulin resistance, and insulin secretion. | 21964962 |
| Hyperglycemia | Deregulated Nutrient Sensing | Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. | 21965330 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a major risk factor for type 2 diabetes mellitus. | 21965330 |
| Hyperglycemia | Deregulated Nutrient Sensing | Liver-specific Sirt1 deficiency caused hepatic glucose overproduction, chronic hyperglycemia, and increased ROS production. | 21965330 |
| Inspiration function | Deregulated Nutrient Sensing | The objective of this work was to investigate the influence of inspiratory muscular training, with Threshold, on insulin resistance in elderly people. | 21973074 |
| Blood Glucose | Deregulated Nutrient Sensing | The experimental group had improved insulin resistance, with decreased glycemia and insulin requirements, a lower homeostatic model assessment of insulin resistance, and increased respiratory force and performance. | 21973074 |
| Inspiration function | Deregulated Nutrient Sensing | The small sample does not allow for conclusions, but we can suggest that inspiratory muscular training improves insulin sensitivity in elderly patients with insulin resistance. | 21973074 |
| Hypoglycemia | Deregulated Nutrient Sensing | Insulin resistance index was improved obviously and no event of hypoglycemia occurred. | 21977859 |
| Hyperglycemia, Hyperuricemia, Malnutrition, Dyslipidemias | Deregulated Nutrient Sensing | The occurrence of hyperglycemia, hyperuricemia, and dyslipidemia and of nutritional deficiencies, among them magnesium (19%), vitamin A (15%), vitamin C (16%), iron (9%), b-carotene (3%), and vitamin B12 (3%), was high. | 21978750 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia is considered one of the most important risk factors for coronary heart disease. | 21981839 |
| Dyslipidemias | Deregulated Nutrient Sensing | Combination therapy with a statin and a fibrate may be more effective than statin monotherapy for reducing hsCRP, especially in patients with mixed dyslipidemia. | 21981842 |
| Dyslipidemias | Deregulated Nutrient Sensing | Combination therapy with rosuvastatin and fenofibric acid may be effective for improving the inflammatory biomarker, hsCRP as well as other lipid abnormalities in patients with mixed dyslipidemia and high hsCRP. | 21981842 |
| Atrial Fibrillation by ECG Finding, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Heart failure, Anemia, Obesity, Cerebrovascular Disorders, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | The most frequent comorbidities were heart failure (59%), diabetes (48%), myocardial infarction (29%), moderate kidney failure (22%), cerebrovascular disease (19%), hypertension (71%), anemia (62%), atrial fibrillation (34%), dyslipidemia (28%) and obesity (21%). | 21982043 |
| Hyperglycemia, Electrocardiogram: myocardial infarction (finding), glucose metabolism | Deregulated Nutrient Sensing | The glucose dysmetabolism in the acute phase of non-diabetic ST-elevation myocardial infarction: from insulin resistance to hyperglycemia. | 21984048 |
| Acute myocardial infarction, Hyperglycemia, myocardial injury | Deregulated Nutrient Sensing | In the setting of acute myocardial infarction, hyperglycemia and acute insulin resistance may represent a stress response to myocardial injury mainly related to acute catecholamine release. | 21984048 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | By measuring glucose values and insulin resistance (Homeostatic Model Assessment index-HOMA), we evaluated in 356 non-diabetic patients with ST-elevation myocardial infarction (STEMI) undergone mechanical revascularization: (a) the acute glycometabolic response by evaluating insulin resistance, glucose levels, and their combination and (b) whether insulin resistance and increased glucose values (and their combination) are able to affect in-Intensive Cardiac Care Unit (ICCU) mortality and complications. | 21984048 |
| Degenerative polyarthritis, Tumor necrosis | Deregulated Nutrient Sensing | Exposing human osteoarthritic (OA) chondrocytes to tumor necrosis factor a (TNFa) generates a stable and enzymatically inactive 75-kd form of SirT1 (75SirT1) via cathepsin B-mediated cleavage. | 21987377 |
| Tumor necrosis | Deregulated Nutrient Sensing | 75-kd sirtuin 1 blocks tumor necrosis factor a-mediated apoptosis in human osteoarthritic chondrocytes. | 21987377 |
| Gestational Diabetes | Deregulated Nutrient Sensing | Resistin may not associate with gestational diabetes mellitus although insulin resistance. | 21995154 |
| Gestational Diabetes | Deregulated Nutrient Sensing | Although mean BMI in GDM was higher than in NGDM and insulin resistance in GDM was more marked than in NGDM, serum resistin levels in GDM were not found to be any different from NGDM. | 21995154 |
| Haploinsufficiency | Deregulated Nutrient Sensing | The consequences of growth hormone-releasing hormone receptor haploinsufficiency for bone quality and insulin resistance. | 21995288 |
| Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | Insulin resistance and atrial fibrillation (from the Framingham Heart Study). | 21996140 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Both diabetes and obesity are associated with insulin resistance. | 21996140 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | At least one dyslipidemia was observed among 212 (66%) including hypercholesterolemia in 121 (38%), high LDL in 135 (42%), hypertriglyceridemia in 110 (34%), and low HDL in 48 (15%) patients. | 21996228 |
| Hypertensive (finding), Dyslipidemias, Overweight, diabetic | Deregulated Nutrient Sensing | The subjects with dyslipidemia were prone to be older, to have CAD before OHT, and to be hypertensive, overweight, and obese, as well as display an higher HbA1C when diabetic. | 21996228 |
| Dyslipidemias | Deregulated Nutrient Sensing | The aim of the study was to describe the occurrence of dyslipidemias among OHT recipients after introduction of guidelines suggesting the use of statins in all individuals able to tolerate this therapy. | 21996228 |
| Dyslipidemias | Deregulated Nutrient Sensing | Despite almost universal use of statins, dyslipidemias were present in 2/3 of OHT recipients. | 21996228 |
| Ischemic stroke | Deregulated Nutrient Sensing | Fasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults. | 21998054 |
| Ischemic stroke | Deregulated Nutrient Sensing | We investigated whether fasting and post-glucose load measures of insulin resistance were related to incident ischemic stroke in nondiabetic, older adults. | 21998054 |
| Ischemic stroke | Deregulated Nutrient Sensing | In nondiabetic, older adults, insulin resistance measured by Gutt index or 2-hour glucose, but not by fasting insulin, was associated with risk of incident ischemic stroke. | 21998054 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | Increase in obesity and metabolic syndrome are associated with increases in insulin resistance (IR) and type 2 diabetes mellitus. | 21999398 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Gender, prevalence of hypertension, and dyslipidemia and alcohol intake were not different between the patients with PAD and those without PAD. | 22000526 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Among men, the prevalence ratios of overweight, consumption of meat with visible fat, and dyslipidemia were higher among men with more schooling, while tobacco use, sedentary lifestyle, and high-blood pressure were lower. | 22002149 |
| Liver Failure, Acute, Hypertrophy | Deregulated Nutrient Sensing | A novel therapy of inducing hepatocyte hypertrophy by activating Akt/mTORC1 pathway in acute liver failure. | 22004987 |
| GTF2A1L wt Allele, Hypertrophy | Deregulated Nutrient Sensing | We hypothesized, therefore, that pharmacological therapy targeting to induce hepatocyte hypertrophy by activating the Akt/mTORC1 pathway might be a novel and promising option in the early management of patients with ALF as an alternative way to impaired process of cell proliferation. | 22004987 |
| Dyslipidemias, Tacca leontopetaloides, Thrombosis of renal artery, Transient Ischemic Attack, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Compared to patients without previous TIAs (non-TIA group), patients with previous TIAs (TIA group) were significantly more likely to have hypertension (76.3% vs 64.3%; P = .016), dyslipidemia (57.0% vs 41.1%; P = .003), chronic kidney disease (28.1% v 15.1%; P = .001), intracranial major artery stenosis (51.8% vs 36.2%; P = .018), and large artery atherothrombosis (43.9% vs 28.3%; P = .002). | 22005036 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes, hypertension, dyslipidemia and previously known CAD, type of MI (STEMI vs NSTEMI) and extent of CAD did not predict cerebrovascular risk. | 22005309 |
| Hypertension, CTCAE, Kidney Failure, Obesity | Deregulated Nutrient Sensing | Higher hypertension risk, present in 42.5% of the overall group of eligible patients (164/387), is associated with high PTH and high RRI, along with greater renal insufficiency, insulin resistance, and obesity. | 22007967 |
| Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | Effects of telmisartan on insulin resistance and visceral fat distribution in Chinese hypertensive patients with obesity. | 22008920 |
| millicurie, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Our results suggest that esRAGE may be a potential protective factor for dyslipidemia, atherosclerosis, and MCI in patients with type 2 diabetes. | 22011410 |
| Hypertension, CTCAE, Cardiovascular Diseases, Hyperuricemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperuricemia is associated with several risk factors for cardiovascular diseases such as hypertension, insulin resistance, and diabetes. | 22011411 |
| Obesity, Abdominal, Hypertriglyceridemia, Dyslipidemias, Obesity, Overweight | Deregulated Nutrient Sensing | Hypertriglyceridemia (52%), low HDL (72.8%), abdominal obesity (60.3%), MS (58.1%), dyslipidemia (88.8%), overweight (74.3%) and obesity (33.8%) were also elevated. | 22011854 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Conversely, carriers of the TNF-a A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes. | 22012292 |
| Dyslipidemias | Deregulated Nutrient Sensing | Whether the anti-atherosclerotic effect of cilostazol is independent of improving pro-atherogenic dyslipidemia is worth further investigation. | 22015232 |
| Erectile dysfunction | Deregulated Nutrient Sensing | Addition of metformin to sildenafil treatment for erectile dysfunction in eugonadal nondiabetic men with insulin resistance. | 22016348 |
| Abnormal circulating valine concentration, Endothelial dysfunction | Deregulated Nutrient Sensing | Insulin resistance (IR) is a metabolic abnormality that produces endothelial dysfunction characterized by decreased synthesis and release of NO. | 22016348 |
| Biliary calculi | Deregulated Nutrient Sensing | Insulin resistance as a risk factor for gallbladder stone formation in Korean postmenopausal women. | 22016589 |
| Biliary calculi, Obesity | Deregulated Nutrient Sensing | In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group. | 22016589 |
| Obesity, Abdominal, Biliary calculi | Deregulated Nutrient Sensing | Insulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity. | 22016589 |
| Chronic Obstructive Airway Disease, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Most patients were male (52%) and had hypertension (84%) and dyslipidemia (84%), with 24% having diabetes mellitus and 20% chronic obstructive pulmonary disease. | 22017933 |
| Obesity | Deregulated Nutrient Sensing | Classically activated macrophage accumulation in adipose tissue is a known feature of obesity, where it is linked with increasing insulin resistance. | 22018099 |
| Chronic heart failure | Deregulated Nutrient Sensing | Study of insulin resistance, TNF-a, total antioxidant capacity and lipid profile in patients with chronic heart failure under exercise. | 22021702 |
| Congestive heart failure | Deregulated Nutrient Sensing | All non-diabetic CHF patients were characterized by insulin resistance. | 22021702 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | There are many pathophysiological mechanisms underlying reciprocal relationships between changes in cytokines and insulin resistance in metabolic and cardiovascular disorders. | 22024218 |
| Tumor necrosis | Deregulated Nutrient Sensing | In addition, significant decreases were found in plasma tumor necrosis factor a (P < .01), which might have contributed to the improvements observed in insulin resistance. | 22024489 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Insulin resistance, low cardiorespiratory fitness, and increased exercise blood pressure: contribution of abdominal obesity. | 22025379 |
| Systolic Pressure | Deregulated Nutrient Sensing | Individuals with an increased waist circumference (>=94 cm and >=80 cm for men and women, respectively) had higher exercise systolic blood pressure compared with individuals with low waist circumference, irrespective of their level of insulin resistance (10.6 versus 6.8, 12.2 versus 7.7, and 13.2 versus 8.7 mm Hg/metabolic equivalent, respectively, for the low, intermediate, and high tertiles; P<0.05) or fitness levels (13.1 versus 8.2, 12.0 versus 7.9, and 10.6 versus 7.1 mm Hg/metabolic equivalent, respectively, for the low, intermediate, and high tertiles; P<0.05). | 22025379 |
| Hepatitis, Obesity, Fatty Liver Disease | Deregulated Nutrient Sensing | IL-1RA serum levels associate with liver inflammation and serum ALT independently of obesity, alcohol consumption and insulin resistance, suggesting a potential use of IL-1RA as a non-invasive inflammatory marker for NASH. | 22027586 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | This association with diabetes mellitus mandates screening for glucose intolerance in all patients with NL. | 22031644 |
| Communicable Diseases | Deregulated Nutrient Sensing | Previous reports have indicated that insulin resistance (IR) is associated with chronic hepatits C virus (HCV) infection. | 22035893 |
| TG gene, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. | 22037512 |
| Dyslipidemias, Dysglycemia, Obesity | Deregulated Nutrient Sensing | Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans. | 22039493 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Dyslipidemia was associated with male gender, age, a family history of dyslipidemia, education at college or above, current smoker, overweight and obesity, intermediate and high waist circumference, hypertension and diabetes. | 22041495 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | The major type of dyslipidemia in Beijing is high LDL-C rather than high TG. | 22041495 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | A comprehensive strategy toward the prevention, screening, treatment, and control of dyslipidemia is needed to slow the epidemic of cardiovascular disease. | 22041495 |
| Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance in dialysis versus non dialysis end stage renal disease patients without diabetes. | 22043573 |
| Uremia, Kidney Failure, Chronic, Chronic kidney disease stage 5 | Deregulated Nutrient Sensing | Insulin resistance is frequently recognized in uremic patients and is a predictor of cardiovascular mortality in end stage renal disease (ESRD) patients. | 22043573 |
| Kidney Failure, Chronic, Diabetes Mellitus | Deregulated Nutrient Sensing | However sparse data are available regarding the effects of different methods of renal dialysis on insulin resistance in ESRD without diabetes. | 22043573 |
| Kidney Failure, Chronic, Diabetes Mellitus | Deregulated Nutrient Sensing | The present study was conducted to evaluate the levels of insulin resistance in dialysis versus non dialysis ESRD patients without diabetes. | 22043573 |
| Communicable Diseases, Liver carcinoma, Hepatitis | Deregulated Nutrient Sensing | Chronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma. | 22044490 |
| Hepatitis A, Hepatitis C, FAM126A gene | Deregulated Nutrient Sensing | Insulin resistance (IR) occurs early in HCV infection and may synergize with viral hepatitis in HCC development. | 22044490 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, FAM126A gene | Deregulated Nutrient Sensing | Egypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV genotype-4 (HCV-4) on prevalence of insulin resistance in chronic hepatitis C (CHC) and HCC in Egyptian patients. | 22044490 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular disease (CVD) risk factors are associated with body mass index z-score (BMISD) and/or insulin resistance (IR). | 22044843 |
| NDUFAB1 gene, Dyslipidemias, Coronary heart disease, Cerebrovascular accident, Hypertension, CTCAE | Deregulated Nutrient Sensing | Evolution of patients with STEMI after ACP is significantly better in patients with non-anterior location, males, without history of coronary disease, stroke, hypertension, dyslipidemia, ischemic time > 6 hours. | 22046807 |
| Pathology | Deregulated Nutrient Sensing | However, more robust evidence is needed on the effectiveness of Motivational Interviewing in treating chronic pathologies -such as dyslipidemia- in patients assisted by general practitioners. | 22054017 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Most patients had hypertension (38%) and dyslipidemia (26%); 51% of the patients actively used ICI, with a median of 3 attempts monthly. | 22055695 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function. | 22056616 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | They were also more likely to have diabetes mellitus, dyslipidemia, prior AMI, or percutaneous/surgical coronary revascularization. | 22057047 |
| Proteinuria, Nephrons, Dyslipidemias | Deregulated Nutrient Sensing | Laboratory data showed nephrotic level of proteinuria and dyslipidemia. | 22057172 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | These results suggested that higher GGT and lower HMW adiponectin levels are synergistically associated with metabolic syndrome and insulin resistance. | 22059425 |
| Diabetes Mellitus, Non-Insulin-Dependent, Mutation-Negative Lynch Syndrome | Deregulated Nutrient Sensing | A fraction of mutation-negative patients presented with insulin-resistance and normal insulin-secretory capacities resembling early-onset type 2 diabetes. | 22060211 |
| Fatty Liver, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Liver Dysfunction | Deregulated Nutrient Sensing | Japanese males with visceral fat type MS are more likely to have dyslipidemia, fatty liver, and liver dysfunction than those with subcutaneous fat type MS. Visceral fat type MS is one of the most significant risk factors for NAFLD in Japanese males with MS. | 22065161 |
| Cardiovascular Diseases, Mood Disorders, Dyslipidemias, Behavior Disorders, Diabetes Mellitus, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | We aimed to evaluate the hypothesis that the presence of an interaction between smoking and being overweight increases the risks of lifestyle-related diseases (hypertension, diabetes mellitus, dyslipidemia, and cardiovascular disease) in outpatients with mood disorders. | 22065307 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | There was no interaction of smoking and being overweight with dyslipidemia. | 22065307 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Aldosterone plays a role in hypertension, and hypertension is prevalent in patients with insulin resistance. | 22068870 |
| Chronic Kidney Diseases, Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | In 50 CKD patients (age 56+-11 years, BMI 25+-4kg/m(2), 46% females, 14% smokers, 86% hypertensives, 52% with dyslipidaemia) the mean vitamin D level was 53+-33nmol/L (21+-13ng/L). | 22071357 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Sex (P=0.0004), hypertension (P=0.0002), dyslipidemia (P=0.0004) and DM (P=0.0061) were associated with log(CAC+1), respectively. | 22072111 |
| Sandawe language, TG gene, Blood Glucose, Hyperglycemia, Dyslipidemias, No metabolic abnormalities | Deregulated Nutrient Sensing | Though the SAD and WC were associated with numerous metabolic abnormalities, only SAD correlated with dyslipidemia (TG and HDL-c) and hyperglycemia (glycemia). | 22072363 |
| Weight decreased | Deregulated Nutrient Sensing | A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. | 22072637 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Atorvastatin treatment do not modify APOE expression, however those individuals without LDL cholesterol goal achievement after atorvastatin treatment according to the IV Brazilian Guidelines for Dyslipidemia and Atherosclerosis Prevention had lower APOE expression than patients with desirable response after the treatment (p < 0.05). | 22074026 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. | 22074727 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The clustering of dyslipidemia, impaired glucose tolerance and hypertension increases the morbidity and mortality from cardiovascular events. | 22075538 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | [Postprandial lipemia induces endothelial dysfunction and higher insulin resistance in healthy subjects]. | 22078763 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In this study, the most important risk factors were hypertension and dyslipidemia. | 22078780 |
| Carcinoma of lung | Deregulated Nutrient Sensing | The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. | 22081070 |
| Carcinoma of lung | Deregulated Nutrient Sensing | This demonstrates that the pro-oncogenic activity of TR3 in lung cancer cells was due to inhibition of p53 and activation of mTORC1. | 22081070 |
| Carcinoma of lung, Lung Neoplasms | Deregulated Nutrient Sensing | DIM-C-pPhOH inhibited growth and induced apoptosis in lung cancer cells and lung tumors in murine orthotopic and metastatic models, and this was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling, demonstrating that inactivators of TR3 represent a novel class of mTORC1 inhibitors. | 22081070 |
| Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Cessation of life, Hypertensive disease | Deregulated Nutrient Sensing | All the risk factors like, dyslipidemia (90%), HTN (68.8%) past smoker (45%), current smoker (32.5%), diabetes (36.3%), family history of coronary artery disease (25%) and sudden death of first degree relatives (8.8%); dyslipidemia was the highest percentage. | 22081177 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | The prevalence of dyslipidaemia and the risk of cardiovascular disease are elevated in patients with type 2 diabetes. | 22081557 |
| Atherosclerosis, Dyslipidemias, Overweight, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. | 22087679 |
| selenium, Dyslipidemias | Deregulated Nutrient Sensing | In a multivariate regression model (R2 = 0.88), RFQIMT remained significantly associated with the dyslipidemia (regression coefficient +- standard error [SE]: 0.057 +- 0.023; p = 0.017), LVMI (regression coefficient +- SE: 0.01 +- 0.001; P < 0.0001) and number of damaged coronaries (regression coefficient +- SE: 0.0174 +- 0.028; P < 0.0001). | 22087814 |
| One Vessel Coronary Disease, Dyslipidemias | Deregulated Nutrient Sensing | Dividing RFQIMT data in tertiles, dyslipidaemia (31 patients with IMT >= 1.20 mm vs 16 with IMT = 0.91-1.19 vs 25 with IMT <= 0.9, p = 0.004), LVMI (153.5 +- 20.6 g/m2 in IMT >= 1.20 mm vs 131.2 +- 8.4 g/m2 in IMT = 0.91-1.19 mm vs 114.3 +- 11.1 g/m2 in IMT <= 0.9 mm, P < 0.001) and number of high stenosed coronary arteries (IMT >= 1.20 mm population more often showed three vessel diseases than IMT <= 0.90 mm one, P < 0.001) seemed to be significantly related to CCA-IMT increases. | 22087814 |
| Obesity | Deregulated Nutrient Sensing | Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. | 22090277 |
| Obesity | Deregulated Nutrient Sensing | Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. | 22090277 |
| Obesity | Deregulated Nutrient Sensing | Our objective was to determine whether BPA associates with obesity and insulin resistance. | 22090277 |
| Obesity, Abdominal, Obesity | Deregulated Nutrient Sensing | BPA was positively associated with generalized obesity, abdominal obesity, and insulin resistance in middle-aged and elderly Chinese adults. | 22090277 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | [The relationship between amount of cigarette smoked and insulin resistance in male patients with coronary artery disease]. | 22093562 |
| Atherosclerosis of renal artery, Dyslipidemias, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | In a multivariate Logistic regression model, advanced age, male gender, obesity or overweight, hypertension and dyslipidemia were independently associated with a higher risk of retinal arterial atherosclerosis. | 22093782 |
| Blood Glucose | Deregulated Nutrient Sensing | Vitamin D supplementation attenuated the increase in glycemia, and increased insulin secretion, but had no effect on insulin resistance. | 22094836 |
| Arteriopathic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance increases the occurrence of new cardiovascular events in patients with manifest arterial disease without known diabetes. | 22098712 |
| Arteriopathic disease, Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with manifest arterial disease without known diabetes, insulin resistance increases with the number of metabolic syndrome components, and elevated insulin resistance increases the risk of new cardiovascular events. | 22098712 |
| Increased insulin level, Excessive glucagon secretion, Liver Cirrhosis | Deregulated Nutrient Sensing | Patients with liver cirrhosis suffer from hyperinsulinemia, hyperglucagonemia and a certain degree of insulin resistance, and portosystemic shunts may be involved in the etiology. | 22099870 |
| Acromegaly | Deregulated Nutrient Sensing | The impact of transsphenoidal surgery on glucose homeostasis and insulin resistance in acromegaly. | 22101993 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Recent studies have shown that FABP4 is secreted from adipocytes and that FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. | 22102888 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Cerebrovascular accident | Deregulated Nutrient Sensing | Among 326 patients (184 males), the most frequent stroke risk factors overall were dyslipidaemia (187), smoking (161), hypertension (105) and obesity (92). | 22107013 |
| Dyslipidemias | Deregulated Nutrient Sensing | This analysis supports the view that LDL-P concentration is not increased by POM3 plus atorvastatin, relative to atorvastatin monotherapy, and is associated with potentially favorable shifts in LDL-P subfractions, Apo CIII and lipoprotein-associated phospholipase A(2) in mixed dyslipidemia. | 22108152 |
| Dyslipidemias | Deregulated Nutrient Sensing | This could be due to an increased incidence of dyslipidemia. | 22108412 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Ultrasonographically detected non-alcoholic fatty liver disease is an independent predictor for identifying patients with insulin resistance in non-obese, non-diabetic middle-aged Asian adults. | 22108448 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Corneal arcus was not associated with dyslipidemia, diabetes mellitus, arterial hypertension, alcohol consumption, or smoking. | 22110074 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | There was a statistically significant reduction in total cholesterolemia (-20%), LDL-C (-31%), and insulin resistance (-10%) with nutraceutical treatment. | 22113535 |
| Dyslipidemias | Deregulated Nutrient Sensing | Association of high Lp() of children of both age groups with atherogenic dyslipidemia of proband-parent requires confirmation. | 22117675 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia (59%) and hypertension (57%) were the most prevalent risk factors. | 22118125 |
| Hyperlipidemia | Deregulated Nutrient Sensing | The S mice were resistant to the inflammatory process, as shown by low immunoreactivity to CD40L, with high plasma HDL levels, and did not develop insulin resistance, even with moderate hyperlipidemia compared to WT. | 22118127 |
| Hyperlipidemia | Deregulated Nutrient Sensing | The HF mice showed severe hyperlipidemia, increased cardiac immunoreactivity to CD40L, pronounced morphological changes in the aortic wall and insulin resistance, associated with a decrease in plasma HDL levels, compared to S. This severe hyperlipidemia in the HF mice can be considered the major metabolic factor inducing oxidative stress in the cardiovascular system, increasing the lipid peroxidation of HDL and hence its removal by the liver, with consequent lowering of plasma HDL levels. | 22118127 |
| Cardiovascular system | Deregulated Nutrient Sensing | High HDL plasma levels are a protective factor against the development of cardiovascular inflammation and insulin resistance in LDLr-/- mice, preventing the development of neointimal lesions. | 22118127 |
| Communicable Diseases, Hepatitis C, deficiency aspects, Liver Cirrhosis | Deregulated Nutrient Sensing | The relationship between selenium (Se) deficiency and insulin resistance has not much been established in persistent hepatitis C virus (HCV) infection, although Se deficiency is often observed in patients with liver cirrhosis. | 22118753 |
| Fibrosis Assessment, Lymphoproliferative Disorder of the Skin | Deregulated Nutrient Sensing | We hypothesized that the decreased serum Se levels were associated with the severity of hepatic fibrosis or insulin resistance in patients with HCV-related chronic liver disease (CLD). | 22118753 |
| Fibrosis, Liver, deficiency aspects | Deregulated Nutrient Sensing | These findings suggest that Se deficiency was associated with the severity of hepatic fibrosis in patients with HCV-related CLD and that Se deficiency was likely to be one of the factors contributing to insulin resistance in those patients. | 22118753 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia among Nigerian oil workers with type 2 diabetes mellitus. | 22120488 |
| diabetic | Deregulated Nutrient Sensing | Serum total cholesterol dyslipidaemia, triglyceride dsylipidaemia and low-density lipoprotein cholesterol dyslipidaemia were found in 26.9%, 19.2% and 9.6% of the diabetic subjects respectively. | 22120488 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia in Nigerian oil workers with T2DM is common and consists mainly of hypertriglycendaemic and low HDL cholesterol. | 22120488 |
| Dyslipidemias | Deregulated Nutrient Sensing | Factors related to development of dyslipidemia were higher in total cholesterol, female gender with high CD4 count and male gender with low CD4 count (p<0.05). | 22122388 |
| Movement Disorders, Hyperprolactinemia, Dyslipidemias, Diabetes Mellitus, Psychiatric, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Psychiatric medications have clear links to obesity, diabetes, dyslipidaemia, hypertension, hyperprolactinaemia and movement disorders. | 22122654 |
| Dyslipidemias, Cataract, Diabetic Retinopathy, Abnormality of the vasculature, Retinal Vein Occlusion, Glaucoma, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia was not significantly associated with the prevalence of glaucoma (P = 0.99), retinal vein occlusions (P = 0.92), diabetic retinopathy (P = 0.49),presence of retinal vascular abnormalities such as focal or general arteriolar narrowing, age-related macular degeneration(P = 0.27), nuclear cataract (P = 0.14), cortical cataract (P = 0.93), and subcapsular cataract (P = 0.67). | 22128290 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Vitamin D plasma levels are associated with the occurrence of metabolic syndrome components and insulin resistance among Canadians and are linked to increased level of insulin resistance. | 22129928 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | All subgroups showed high rates of hypertension, dyslipidemia, diabetes, and smoking, with the highest rates observed in the northeast region. | 22137071 |
| glycation, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with diabetes mellitus are known to have increased serum levels of advanced glycation end-products (AGEs), and this is also associated with insulin resistance. | 22137116 |
| Excessive glucagon secretion, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance, reduced b-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). | 22140505 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. | 22144216 |
| Acanthosis Nigricans, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hypovitaminosis D, common in obese adolescents at risk for type 2 diabetes (older age, puberty, acanthosis nigricans) is associated with worse insulin resistance. | 22144216 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | While analyzing the interaction between DD and the individual risk factor of hypertension, smoking and dyslipidemia, patients with the risk factor and with DD had the highest risk compared to referent patients without the risk factor and with II/ID. | 22144991 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, traditional risk factors (hypertension, smoking and dyslipidemia) play an important role in the association between ACE genotypes and PAD. | 22144991 |
| Obesity | Deregulated Nutrient Sensing | Leisure time and occupational physical activity in relation to obesity and insulin resistance: a population-based study from the Skaraborg Project in Sweden. | 22146090 |
| Obesity | Deregulated Nutrient Sensing | The observed sex differences regarding the strength of the association between LTPA and insulin resistance, and the positive association between OPA and obesity and insulin resistance found solely in women, warrant further investigation. | 22146090 |
| Liver carcinoma | Deregulated Nutrient Sensing | SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis. | 22146883 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | The purpose of this study is to elucidate the clinicopathological and functional significance of SIRT1 expression in hepatocellular carcinoma (HCC). | 22146883 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1 expression in HCC was determined by immunohistochemical staining. | 22146883 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1 was overexpressed in HCC cell line SK-Hep1 to study its role in tumorigenesis and resistance to chemotherapy. | 22146883 |
| Neoplasms | Deregulated Nutrient Sensing | SIRT1 overexpression was associated with higher a-fetoprotein level, higher tumor grade, and absence of b-catenin mutation. | 22146883 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1 expression predicted poor long-term survival for patients with resected HCC. | 22146883 |
| FAM126A gene | Deregulated Nutrient Sensing | The elevated SIRT1 protein level in HCC was not attributable to the elevation of mRNA level. | 22146883 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1 is an oncogenic protein for HCC and is a predictor of worse outcome after surgical resection of HCC. | 22146883 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Several insulin receptor substrate-2 (IRS-2) polymorphisms have been studied in relation to insulin resistance and type 2 diabetes. | 22147666 |
| Malignant tumor of colon, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Cerebrovascular accident, Degenerative polyarthritis, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, stroke, colon cancer and osteoarthritis were selected as obesity-related diseases. | 22147988 |
| Increased insulin level | Deregulated Nutrient Sensing | The more pronounced risk decreases at the lower range among participants without insulin resistance support a role for adiponectin that is independent of baseline hyperinsulinemia, but this will require further investigation. | 22148099 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | With a high prevalence of dyslipidemia and pro-inflammatory factors, the population is at substantial risk for cardiovascular diseases. | 22149059 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 and the clock gene machinery in colorectal cancer. | 22149272 |
| Carcinogenesis | Deregulated Nutrient Sensing | SIRT1 and the clock genes are involved in carcinogenesis. | 22149272 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | We evaluated SIRT1 expression in 19 human colorectal cancer (CRC) specimens and clock gene expression in SIRT1-overexpressing CaCo2 and SW480 cells. | 22149272 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | In CRC, SIRT1 mean expression level was decreased. | 22149272 |
| ARCN1 gene, Impaired health | Deregulated Nutrient Sensing | These patients may constitute a specific COPD phenotype with greater leptin to adiponectin imbalance and insulin resistance, despite smaller impairment in PFTs. | 22149401 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. | 22151790 |
| Intervertebral Disc Degeneration | Deregulated Nutrient Sensing | SIRT1 treatment significantly reduced aggrecan, Sox9 and collagen type 2 mRNA expression in a dose-dependent manner in all disease classes and disc degeneration grades. | 22152608 |
| Spinal stenosis of lumbar region, Prolapsed lumbar disc | Deregulated Nutrient Sensing | Proliferation activity was decreased by SIRT1 treatment in lumbar spinal stenosis and lumbar disc herniation, Pfirrmann grade 3 and grade 4 discs. | 22152608 |
| Intervertebral Disc Degeneration | Deregulated Nutrient Sensing | SIRT1 affected both extracellular matrix metabolism and proliferation activity; the effect of SIRT1 was altered according to disease class and disc degeneration grade. | 22152608 |
| Intervertebral Disc Degeneration | Deregulated Nutrient Sensing | SIRT1 appears to play a key role in homeostasis during the human intervertebral disc degeneration process. | 22152608 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Overall 63.9% had dyslipidaemia with hypertriglyceridaemia and hypo-HDL being the most common (28% and 45%, respectively), while 2% had hypercholesterolaemia or hyper-LDL. | 22155918 |
| Fibrosis, Liver, Steatohepatitis, Hepatitis, Chronic | Deregulated Nutrient Sensing | Correlation between insulin resistance and outcome of pegylated interferon and ribavirin therapy, hepatic steatosis, hepatic fibrosis in chronic hepatitis C-1b and high viral load. | 22156479 |
| Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance (IR) has been reported to be an independent predictor of treatment outcome in chronic hepatitis C patients. | 22156479 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | HIV infection and exposure to certain antiretroviral drugs is associated with dyslipidemia and increased risk for coronary events. | 22156913 |
| Retinal Diseases, Complications of Diabetes Mellitus, Kidney Diseases | Deregulated Nutrient Sensing | Rapamycin is considered for prevention of diabetic complications, such as retinopathy and nephropathy, and acute treatment with rapamycin decreases insulin resistance. | 22157190 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | It was somehow forgotten that almost two centuries ago, Claude Bernard discovered "starvation diabetes," as shown later, characterized by glucose intolerance, decreased insulin, increased lipoproteins and ketones, gluconeogenesis and hepatic resistance to insulin. | 22157190 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, under certain conditions, chronic administration of rapamycin may cause glucose intolerance and even provoke type II diabetes. | 22157190 |
| Dyslipidemias, Chronic Kidney Insufficiency, Hypertension, CTCAE | Deregulated Nutrient Sensing | He had a clinical history of hypertension, dyslipidaemia and chronic renal impairment. | 22157483 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prescription use and frequency of lipid measurement suggested improved control resulting from a targeted approach to managing specific dyslipidemias. | 22166083 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | In studies performed in mice, rose hip powder has been shown to both prevent and reverse high-fat diet-induced obesity and glucose intolerance as well as reduce plasma levels of cholesterol. | 22166897 |
| Insulin resistance syndrome | Deregulated Nutrient Sensing | No associations between visfatin and other parameters of the insulin-resistance syndrome as well as macronutrient intake were detectable. | 22167446 |
| Dyslipidemias, Cerebrovascular accident, Heart Diseases, Acute myocardial infarction, Obesity, Kidney Failure | Deregulated Nutrient Sensing | Inferential analysis showed a significant association with history of heart disease, renal failure, dyslipidemia, smoking and obesity, as well as the causes of admission of stroke and acute myocardial infarction. | 22169369 |
| Fetal Growth Retardation, Diabetes Mellitus | Deregulated Nutrient Sensing | While the association of IUGR and adult MS, including diabetes, has been well documented, these subjects did not have typical manifestations of MS. Abnormalities in common components that could result in a combination of IUGR, severe postnatal growth, and insulin resistance have been ruled out. | 22170795 |
| Steatohepatitis, Fibrosis Assessment | Deregulated Nutrient Sensing | In genotype-1 infected patients, SVR was associated with a lower grade of liver steatosis, milder fibrosis, and an absence of insulin resistance. | 22171144 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Disorders of glucose metabolism and insulin resistance in patients with obstructive sleep apnoea syndrome. | 22171909 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) and disorders of glucose metabolism (DGM) are risk factors for cardiovascular diseases. | 22171909 |
| Overweight | Deregulated Nutrient Sensing | Among the overweight or obese children, the boys with the increased ALT level had higher BMI, waist circumference, blood pressure, triglyceride, low density lipoprotein and insulin resistance index than the boys with normal ALT level (P<0.05); the girls with the increased ALT level had higher waist circumference, blood pressure and insulin resistance index and lower high density lipoprotein than the girls with normal ALT level (P<0.05). | 22172257 |
| Metabolic Diseases, Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | ALT is correlated with overweight and obesity and metabolic disorders caused by overweight and obesity such as dyslipidemia and insulin resistance. | 22172257 |
| Inflammation, Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Apolipoprotein E gene polymorphisms are strong predictors of inflammation and dyslipidemia in rheumatoid arthritis. | 22174202 |
| Refractory anemias, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia in RA may be driven by inflammation and genetic factors. | 22174202 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and excess risk of diabetes in Mexican-Americans: the San Antonio Heart Study. | 22174423 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Mexican-Americans have more diabetes than non-Hispanic whites, but the extent to which insulin resistance and insulin secretion explain the ethnic difference is unknown. | 22174423 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance accounts for a large and significant proportion of the excess risk of diabetes in Mexican-Americans. | 22174423 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | After controlling for age, the rates of abdominal obesity, family history of diabetes, dyslipidemia and hypertension increased from 21.56% (1715/7956), 4.39% (349/7956), 26.34% (2096/7956) and 11.53% (917/7956) to 31.88% (2706/8487), 12.84% (1090/8487), 41.38%(3512/8487) and 14.61% (1240/8487) respectively (kh(2) = 5.52, 14.83, 18.38 and 20.22, P < 0.01). | 22177305 |
| Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | For diabetes, the PARP of aging, dyslipidemia and abdominal obesity were 41.55%, 29.25% and 25.10% respectively. | 22177305 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Asthma (10.8%), hypertension (10.4%) and dyslipidaemia (9.8%) were the main chronic conditions. | 22178521 |
| Hypertension, CTCAE, Prehypertension | Deregulated Nutrient Sensing | Insulin resistance, prehypertension, hypertension and blood pressure values in paediatric age. | 22179078 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effects of pinitol on glycemic control, insulin resistance and adipocytokine levels in patients with type 2 diabetes mellitus. | 22179130 |
| diabetic | Deregulated Nutrient Sensing | We evaluated the effects of pinitol on glycemic control, insulin resistance and adipocytokine levels in type 2 diabetic patients. | 22179130 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pinitol can mediate insulin action to improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus, especially in patients with insulin resistance. | 22179130 |
| Non-alcoholic Fatty Liver Disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | It has been observed that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease and insulin resistance. | 22181832 |
| Acute lymphocytic leukemia | Deregulated Nutrient Sensing | The prevalence of insulin resistance and other cardiometabolic risk factors is increased in ALL survivors, and insufficient physical activity (PA) and low cardiopulmonary fitness are common. | 22184098 |
| diabetic | Deregulated Nutrient Sensing | In addition, lymphocyte levels of HO-1, Hsp70, Trx and TrxR-1 (P<0.05 and P<0.01) in diabetic patients were higher than in normal subjects, while sirtuin-1 and sirtuin-2 protein was significantly decreased (p<0.05). | 22186191 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Polymorphism of adiponectin (45T/G) and adiponectin receptor-2 (795G/A) in an Iranian population: relation with insulin resistance and response to treatment with pioglitazone in patients with type 2 diabetes mellitus. | 22187345 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | [CoLaus: diabetes and dyslipidemia, there is always something new!]. | 22187780 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | They are associated with well known risk factors such as diabetes and dyslipidemia. | 22187780 |
| Abnormal circulating valine concentration, Williams Syndrome | Deregulated Nutrient Sensing | This case demonstrates the early clinical features of WS and suggests that metabolic abnormality, including insulin resistance, is not an essential component of WS at disease onset. | 22188495 |
| Atrial Fibrillation, Dyslipidemias | Deregulated Nutrient Sensing | We compared the efficacy and safety of atorvastatin (A-group, n = 43) and pravastatin (P-group, n = 41) as upstream therapy in patients with paroxysmal AF and dyslipidemia. | 22188709 |
| Hyperparathyroidism, Primary | Deregulated Nutrient Sensing | Primary hyperparathyroidism (pHPT) is characterized by an increased frequency of glucose tolerance abnormalities associated with insulin resistance. | 22189414 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, diabetes mellitus, and dyslipidemia were more common in the middle-aged group (p<0.05). | 22189478 |
| Hyperandrogenemia, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In women with PCOS, hyperandrogenemia appears to diminish during reproductive life whereas insulin resistance worsens. | 22192350 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors included smoking (47%), hypertension (70%), dyslipidemia (66%), and diabetes mellitus (25%). | 22192370 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Insulin resistance and arterial stiffness in healthy adolescents and young adults. | 22193511 |
| Arterial Stiffness, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased arterial stiffness is a risk factor for adverse cardiovascular events in adults with obesity-related insulin resistance (IR) or type 2 diabetes mellitus. | 22193511 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia were also paradoxically associated with better survival in our model (HR 0.74, CI 0.59-0.92; and HR 0.77, CI 0.63-0.94; respectively; both P < .05). | 22196843 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus type 2 with dyslipidemia is a common disease. | 22198821 |
| Calcification of coronary artery | Deregulated Nutrient Sensing | SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients. | 22200427 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Influence of lifestyle habits, nutritional status and insulin resistance in NAFLD. | 22201932 |
| Fatty Liver Disease, Non-alcoholic Fatty Liver Disease, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Non alcoholic fatty liver disease (NAFLD) is associated with obesity, diabetes and insulin resistance (IR). | 22201932 |
| Dyslipidemias | Deregulated Nutrient Sensing | These data suggest that an increased cadmium body burden increases the risk of dyslipidemia, mainly due to the increased risk of low HDL-C and the high ratio of triglycerides to HDL-C. | 22208951 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It has been suggested that sex steroid hormones may play a causal role in the development of insulin resistance and type II diabetes. | 22211848 |
| Presenile dementia, Inflammation, "Alzheimers Disease | Deregulated Nutrient Sensing | Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. | 22213409 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We conclude that MS is associated with an altered hemorheological profile related to inflammatory, lipidic and glucose intolerance parameters which could favor the development of thrombo-embolic and athero-thrombotic events in MS patients. | 22214720 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up. | 22215126 |
| Primary malignant neoplasm, Diabetes Mellitus, Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | Age- and sex-adjusted analysis showed that hyperinsulinemia/insulin resistance is associated with cancer mortality independently of diabetes, obesity/visceral obesity and the metabolic syndrome. | 22215126 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | In 108 adolescents, diagnoses included 40.7% with T2DM, 25.0% with prediabetes, and 34.3% with insulin resistance. | 22217471 |
| Dyslipidemias, Deep thrombophlebitis, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Univariate linear models showed that obesity (p=0.010), dyslipidemia (p=0.004), arterial hypertension (p=0.046), use of platelet anti-aggregating agents (p=0.018) and DVT (p<0.001) were associated to lower levels of FMD. | 22217989 |
| Dyslipidemias, Deep thrombophlebitis | Deregulated Nutrient Sensing | Univariate logistic regression models showed that dyslipidemia (p=0.008), use of platelet anti-aggregating agents (p=0.004) and DVT (p<0.001) were associated to a higher risk of having FMD <= 8.5%. | 22217989 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Age of risk for CAD were found in 30.0%, hypertension in 55.0%, diabetes in 10.0%, smoking in 35.0%, dyslipidemia in 67.5% and family history of CAD in 57.5%. | 22218509 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and g-GT activity were significantly higher in NASH subjects. | 22219597 |
| Subarachnoid Hemorrhage | Deregulated Nutrient Sensing | Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage. | 22230897 |
| Cerebral Vasospasm | Deregulated Nutrient Sensing | Adiponectin plays an important role against cerebral vasospasm via the AMPK/eNOS signaling pathway. | 22230897 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine the benefit of neutral protamine Hagedorn (NPH) insulin compared with insulin glargine in a patient with type 2 diabetes mellitus and severe insulin resistance. | 22232027 |
| Cardiac Hypertrophy, Acromegaly | Deregulated Nutrient Sensing | Newly diagnosed acromegalic patients without cardiac hypertrophy display a decreased sympathetic outflow in spite of insulin resistance. | 22233452 |
| Dyslipidemias, Coronary Arteriosclerosis, Hypothyroidism | Deregulated Nutrient Sensing | Hypothyroidism is a well-known cause of secondary dyslipidaemia and may therefore predispose to the development of atherosclerotic disease. | 22236619 |
| Thyroid dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | In addition, these cases demonstrate that clinical and biochemical screening for thyroid dysfunction is of paramount importance in all dyslipidaemia patients to prevent inappropriate initiation of lipid-lowering therapy. | 22236619 |
| Chronic Lymphocytic Leukemia | Deregulated Nutrient Sensing | The results showed: (1) HDAC isoenzyme levels in CLL were significantly increased in class I including HDAC1 and HDAC3, in class II including HADC6, HDAC7, HDAC9 and HDAC10, and in class III including SIRT1 and SIRT6; (2) higher expression of HDAC isoenzyme levels was found in ZAP-70+ compared to ZAP-70- patients, and CD44 expression levels were correlated with HDAC isoenzyme expression levels in the majority of HDAC classes. | 22237050 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pharmacological augmentation of glucagon-like peptide 1 receptor signalling by dipeptidyl peptidase 4 (DPP-4) inhibition reduced intestinal lipoprotein secretion in experimental studies, suggesting that DPP-4 inhibitors may ameliorate dyslipidaemia and thus reduce cardiovascular risk in patients with type 2 diabetes. | 22237690 |
| Hepatitis C, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance have been reported as negative predictors for sustained virological response (SVR) in hepatitis C virus (HCV) genotype 1 infected patients treated with pegylated interferon-a plus ribavirin. | 22239510 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | However, it is still unclear whether RHR can also be applied as a screening for other risk factors, such as hyperglycemia and dyslipidemia. | 22239980 |
| Increased insulin level | Deregulated Nutrient Sensing | This study confirms that red cell aggregability is associated with insulin resistance and hyperinsulinemia, but plasma viscosity seems to be more related to overall glucose tolerance than to either SI or insulinemia. | 22240354 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The findings indicate that both MRT and ERT lead to decreased insulin resistance in people with a risk of developing type 2 diabetes; MRT led to a greater increase in glucose uptake capacity (in muscles), whereas ERT led to greater insulin sensitivity, supporting the recommendation of both MRT and ERT as primary intervention approaches for individuals at a risk of developing type 2 diabetes. | 22240549 |
| Chronic heart failure, Endothelial dysfunction | Deregulated Nutrient Sensing | Chronic heart failure is associated with endothelial dysfunction and insulin resistance. | 22241951 |
| Diabetes Mellitus, Non-Insulin-Dependent, Heart Failure, Systolic | Deregulated Nutrient Sensing | Systolic heart failure and type 2 diabetes result in similar vascular insulin resistance and reduced muscular insulin-stimulated glucose uptake. | 22241951 |
| diabetic | Deregulated Nutrient Sensing | Visceral fat mass is always, but adipokines (adiponectin and resistin) are diversely associated with insulin resistance in Chinese type 2 diabetic and normoglycemic subjects. | 22244787 |
| Weight Gain, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Among the general population, weight gain, and baseline insulin resistance are predictors for NAFLD incidence. | 22245895 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | It has been suggested that association between hypothyroidism with dyslipidemia might be present already at the stage of normal thyroid function through altered insulin sensitivity. | 22246849 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Abdominal obesity rather than atherogenic dyslipidemia was the primary cause of chronic inflammatory status. | 22246850 |
| Dyslipidemias | Deregulated Nutrient Sensing | Protein oxidative stress and dyslipidemia in dialysis patients. | 22248198 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Hemodialysis patients had increased protein OS and associations of inflammation and dyslipidemia were also observed in these dialysis groups. | 22248198 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X | Deregulated Nutrient Sensing | The association of metabolic syndrome, insulin resistance and non-alcoholic fatty liver disease in overweight/obese children. | 22249092 |
| AURKAIP1 gene, Glucose Intolerance (disease), Autoimmune Pancreatitis | Deregulated Nutrient Sensing | Glucose intolerance is often observed in autoimmune pancreatitis (AIP), although its long-term prognosis after steroid treatment (ST) is still unclear. | 22249131 |
| Eruptive xanthoma, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes was discovered only after the appearance of cutaneous eruptive xanthomata, which appeared due to the previously undiagnosed genetic dyslipidemia. | 22251869 |
| Dyslipidemias, Kidney Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with vitD insufficiency had dyslipidemia and diabetes more frequently. | 22252845 |
| Lipodystrophy, Dyslipidemias | Deregulated Nutrient Sensing | Treated HIV-1-infected patients with lipodystrophy often develop insulin resistance and proatherogenic dyslipidaemia. | 22256965 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Primary outcomes are changes in insulin resistance and BMI after 12 months; secondary outcomes include changes in diet patterns, physical activity, waist circumference, and perceived risk of developing diabetes. | 22257365 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, dyslipidemia and overweight are related to lower testosterone levels in a cohort of men undergoing prostate biopsy. | 22258063 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Overweight, Cardiovascular system | Deregulated Nutrient Sensing | Hypertension, diabetes mellitus (DM), dyslipidemia and overweight are four clinical factors strongly related to cardiovascular illnesses. | 22258063 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Levels of testosterone were related to hypertension (P=0.007), dyslipidemia (P=0.013), overweight (P=0.036) and the number of cardiovascular risk factors (P=0.018). | 22258063 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic inflammation and decreased frequency of regulatory T cells (Tregs) in visceral adipose tissue contribute to the propagation of insulin resistance to diabetes mellitus. | 22262764 |
| Gastritis, Glucose Intolerance (disease), Chronic Obstructive Airway Disease, Depression, CTCAE, Hypertension, CTCAE | Deregulated Nutrient Sensing | She also suffered from glucose intolerance, gastritis, chronic obstructive pulmonary disease, hypertension and depression as comorbidities. | 22263389 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Statins are the standard-of-care therapy for reducing low-density lipoprotein cholesterol (LDL-C) levels; however, combination with other lipid-modifying agents may be necessary to normalize lipid profiles in patients with mixed dyslipidemia who, in addition to high LDL-C, also have high triglycerides (TG) and low levels of high-density lipoprotein cholesterol (HDL-C). | 22263674 |
| Presenile dementia, Parkinson Disease | Deregulated Nutrient Sensing | Dementia is associated with insulin resistance in patients with Parkinson's disease. | 22265943 |
| Parkinson Disease, Presenile dementia, Diabetes Mellitus | Deregulated Nutrient Sensing | The insulin resistance was present in 62% patients with Parkinson's disease with dementia, of whom 30% had also impaired glucose tolerance, 5,6% newly diagnosed Diabetes Mellitus and 26% only Insulin Resistance. | 22265943 |
| palladium, Presenile dementia | Deregulated Nutrient Sensing | Our study suggests that PD patients with dementia are two times more likely to have insulin resistance than patients with PD. | 22265943 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | The presence of ED was related to HT (OR: 1.805 [1.128-2.887]; p=0.013), DM (OR 3.585 [1.613-7.966]; p=0.001) and Dyslipidemia (OR: 1.928 [1.062-3.500]; p=0.029). | 22266257 |
| Dyslipidemias, Demographics Domain, Haiti | Deregulated Nutrient Sensing | The presence and severity of ED correlate with the presence of HT, DM, Dyslipidemia and the number of DVRF. | 22266257 |
| Feeding behaviors | Deregulated Nutrient Sensing | There was no significant relationship between eating behaviour in PWS subjects and the levels of any hormones or insulin resistance, independent of age. | 22270375 |
| Increased insulin level, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Because insulin resistance and compensatory hyperinsulinemia are observed in 50-70% of individuals with PCOS, deregulated insulin signaling in the ovary is considered an important factor in the disease. | 22275470 |
| Increased insulin level, Hyperamylasemia, Obesity | Deregulated Nutrient Sensing | Hyperamylinemia is common in patients with obesity and insulin resistance, coincides with hyperinsulinemia, and results in amyloid deposition. | 22275486 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Overall, 67.9% of the patients had hypertension, 27.5% were diabetics and 57.4% had dyslipidemia. | 22275741 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Fatty liver disease and insulin resistance may be mediators of this high ferritin-hypertension association. | 22278211 |
| Migraine Disorders | Deregulated Nutrient Sensing | Insulin resistance correlated with duration of migraine attacks. | 22278639 |
| Infection caused by Helicobacter pylori | Deregulated Nutrient Sensing | Controlling for insulin resistance, C-reactive protein and interleukin-6 did not attenuate the effect of H. pylori infection. | 22279028 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The main co-morbidities were hypertension (53.8%), dyslipidemia (47.2%), and hyperglycemia/diabetes mellitus (15.0%). | 22281230 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance. | 22283633 |
| FAM126A gene | Deregulated Nutrient Sensing | Significant correlations of serum adiponectin levels with serum triglyceride levels and insulin resistance were found in the controls, but not in the HCC patients. | 22287480 |
| Dyslipidemias, Hypertension, CTCAE, atherosclerotic, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjusting for age, gender, high sensitivity c-reactive protein, serum glucose and the presence of diabetes, hypertension, smoking, dyslipidemia, antidiabetic drugs, lipid-lowering drugs, and atherosclerotic plaques, it was seen that for every 0.1 point increase in WHtR, and for every cm increase in WC, the PWV increased 0.041 and 0.029 m/sec, and C-IMT increased 0.001 mm and 0.001 mm, respectively. | 22292502 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Although the prevalence of hypertension, dyslipidemia and diabetes mellitus were similar between Japan and USA, there was a trend towards fewer patients in Japan displaying a history of coronary revascularization. | 22293799 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Receiver operating curve (ROC) analyses showed that WtHR was a better predictor than all other AI for hypertension and dyslipidemia. | 22293890 |
| Hyperglycemia | Deregulated Nutrient Sensing | Chromium appears to improve hyperglycemia and insulin resistance in acutely ill patients and represents a potential new therapy. | 22297054 |
| Coronary Arteriosclerosis, Obesity | Deregulated Nutrient Sensing | The protein lipocalin (LCN)-2 is known to be related to insulin resistance, obesity and atherosclerotic diseases. | 22300286 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Determinants of uncontrolled dyslipidaemia among adult type 2 diabetes in Malaysia: the Malaysian Diabetes Registry 2009. | 22305940 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Numerous studies with compelling evidence had shown a clear relationship between dyslipidaemia and cardiovascular (CV) events in patients with diabetes mellitus. | 22305940 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | This was an observational study based on secondary data from the online registry database Adult Diabetes Control and Management (ADCM) looking into the determinants of uncontrolled dyslipidaemia in type 2 diabetes mellitus patients. | 22305940 |
| Dyslipidemias | Deregulated Nutrient Sensing | This study has highlighted the suboptimal management of diabetic dyslipidaemia in Malaysia. | 22305940 |
| Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance (IR), and progressive decline in pancreatic b-cell function are major features of type 2 diabetes mellitus (T2DM). | 22307870 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Most patients were male (95%), non-Hispanic white (80%), older than 50 (mean+-SD=61+-12) with comorbid hypertension (65%) and dyslipidemia (50%). | 22307880 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | The finding that improvements in obesity-associated insulin resistance following pioglitazone were associated with increased adipocyte cell surface and systemic adiponectin levels, supports the centrality of AT to the cardiometabolic derangement underlying the development of T2D (Type 2 diabetes) and CVD (cardiovascular disease). | 22309242 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | HbA1c associates with atherogenic dyslipidemia particularly with TG and TG/HDL-C ratio, but not with TC, HDL-C, or LDL-C. HbA1c is not associated with hs-CRP, and with functional fitness and aerobic endurance. | 22309488 |
| Inflammation | Deregulated Nutrient Sensing | The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning. | 22310233 |
| Inflammation | Deregulated Nutrient Sensing | Furthermore, there is evidence that obesity-related physiological states, such as insulin resistance and systemic inflammation, may exacerbate physical functioning problems. | 22310233 |
| Weight decreased, Obesity | Deregulated Nutrient Sensing | SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. | 22310473 |
| Weight decreased | Deregulated Nutrient Sensing | Subjects carrying minor alleles at SIRT1 and CLOCK loci (R group) displayed a higher resistance to weight loss and a lower weekly weight loss rate as compared with homozygotes for both major alleles (P group). | 22310473 |
| Weight decreased | Deregulated Nutrient Sensing | Variants of both SIRT1 and CLOCK have an additive effect on resistance to weight loss that could be related to the chronotype of the subject, higher plasma levels of ghrelin and less adherence to Mediterranean diet patterns. | 22310473 |
| Consortium for Molecular and Cellular Characterization of Screen-Detected Lesions | Deregulated Nutrient Sensing | Pharmacologic suppression of Akt, but not of TORC1, increases Noxa protein levels and downregulates Bfl-1 protein supporting the conclusion that the inhibition of the Akt pathway, the resulting FOXO3a activation and Noxa upregulation are critical molecular mechanisms underlying RA/IFN-a-dependent MCL cell apoptosis. | 22311672 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are potentially modifiable cardiovascular risk factors. | 22313142 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | We studied hypertensive outpatients regarding goal attainment in controlling dyslipidemia, according to individual cardiovascular risk profile, following the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. | 22313142 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The control of dyslipidemia in hypertensive patients is far from ideal and results are even worse in individuals with CVD. | 22313142 |
| Cardiac Hypertrophy, Failure (biologic function) | Deregulated Nutrient Sensing | It has been shown that AMPK activity is increased in cardiac hypertrophy and failure but it is unknown whether changes in subunit composition of AMPK contribute to the altered AMPK activity. | 22314372 |
| Cardiac Hypertrophy, Heart failure | Deregulated Nutrient Sensing | In this study, we determined the protein expression pattern of AMPK subunit isoforms during cardiac development as well as during cardiac hypertrophy and heart failure in mouse heart. | 22314372 |
| Disease | Deregulated Nutrient Sensing | We also compared the findings in failing mouse heart to that of the human failing hearts in order to determine whether the mouse heart is a good model of AMPK in human diseases. | 22314372 |
| Heart failure | Deregulated Nutrient Sensing | In summary, the protein level and the isoform distribution of AMPK in the heart change significantly during normal development as well as in heart failure. | 22314372 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension was the most important risk factor and other risk factors were smoking, diabetes mellitus, tobacco chewing, ischemic heart disease, dyslipidemia, oral contraceptive pill, alcohol consumption, atrial fibrillation and past history of stroke. | 22314448 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Despite the low prevalence of hypertension, dyslipidemia and diabetes, their tendency to cluster and the increased prevalence among overweight/obese women highlight the high level of risk of this young female population. | 22314542 |
| Hypertension, CTCAE, Demographics Domain, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | When we compared TST level and morbidity, we found significantly more patients with diabetes mellitus (DM), hypertension and dyslipidemia in group with TST below 10 nmol/l. | 22315154 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest that niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and that the mechanism may involve inhibition of DGAT2. | 22315393 |
| Glucose Intolerance (disease), Hypertriglyceridemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | For each 5-unit increase in CES-D score, odds increased by 47.6% for having hypertriglyceridemia, by 51.8% for having hypertension, and by 56.7% for having glucose intolerance. | 22315628 |
| Hyperlipidemia, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | It is one of the most significant contributors to ill health and an indirect cause of morbidity and mortality resulting from hyperlipidaemia and glucose intolerance. | 22315858 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Over 50% of participants had hypertension or dyslipidemia and were taking 3 or more medications. | 22316643 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | It is often associated with obesity, diabetes and dyslipidemia. | 22317765 |
| Cessation of life, Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | This ability of CK2-Is to sensitize glioma to TNFa-induced death via multiple mechanisms involving abrogation of NF-kB activation, reactivation of wild-type p53 function and SIRT1 inhibition warrants investigation. | 22318540 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland. | 22318870 |
| Steatohepatitis, Hypocholesterolemia | Deregulated Nutrient Sensing | How this interference results in the frequently observed, genotype-dependent clinical sequelae of hypocholesterolemia, hepatic steatosis, and insulin resistance (IR) remains incompletely understood. | 22318926 |
| Pheochromocytoma, Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Pheochromocytomas have been described to lead to hyperglycemia and diabetes, due to the suppression of insulin release and increased insulin resistance. | 22322656 |
| Leukemia, T-Cell | Deregulated Nutrient Sensing | High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. | 22322739 |
| TRPV6 gene | Deregulated Nutrient Sensing | SIRT1, a nicotinamide adenine dinucleotide(+)-dependent histone/protein deacetylase, plays a crucial role in various physiological processes, such as aging, metabolism, neurogenesis and apoptosis, owing to its ability to deacetylate numerous substrates, such as histone and NF-kB, which is implicated as an exacerbation factor in ATL. | 22322739 |
| TRPV6 gene | Deregulated Nutrient Sensing | SIRT1 expression in ATL patients was significantly higher than that in healthy controls, especially in the acute type. | 22322739 |
| TRPV6 gene | Deregulated Nutrient Sensing | Sirtinol, a SIRT1 inhibitor, induced significant growth inhibition or apoptosis in cells from ATL patients and leukemic cell lines, especially HTLV-1-related cell lines. | 22322739 |
| TRPV6 gene, leukemia | Deregulated Nutrient Sensing | These results suggest that SIRT1 is a crucial antiapoptotic molecule in ATL cells and that SIRT1 inhibitors may be useful therapeutic agents for leukemia, especially in patients with ATL. | 22322739 |
| Alzheimers Disease | Deregulated Nutrient Sensing | aChE and BuChE inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with Alzheimer disease. | 22323348 |
| Alzheimers Disease", Loading Technique | Deregulated Nutrient Sensing | Insulin resistance (IR) may play a role in most pathogenic processes that promote the development of Late Onset Alzheimer Disease (LOAD). | 22323348 |
| Dyslipidemias, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | FHT2DH was not associated with risk factors for cardiovascular disease, such as dyslipidemia (OR = 1.12, 95% CI = 0.70-1.79) and FRS (OR = 0.74, 95% CI = 0.40-1.36) when adjusted for gender, age, smoking and obesity. | 22324835 |
| Glucose Intolerance (disease), Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | These findings suggest that, in patients with CHD, elevated 1hPG increases coronary risk factors and may be a marker for early-stage glucose intolerance. | 22324971 |
| Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | In addition, documented presence of ischemic heart disease (IHD), stroke, diabetes mellitus, hypertension and dyslipidemia were determined from medical files. | 22326028 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Male sex, older age, hypertension, diabetes mellitus, smoking, and dyslipidemia all increased the likelihood of the presence of CAP in univariate analysis (P<0.001). | 22327064 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Older age, male sex, dyslipidemia, and diabetes mellitus independently increased the likelihood of the presence of CAP in multivariate analysis (P<0.005). | 22327064 |
| Hyperparathyroidism, Primary | Deregulated Nutrient Sensing | Investigation of insulin resistance in patients with normocalcemic primary hyperparathyroidism. | 22327928 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Patients with NPHPT do not exhibit insulin resistance and glucose intolerance. | 22327928 |
| Neoplasms | Deregulated Nutrient Sensing | A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. | 22331558 |
| Malignant Neoplasms, Neoplasms | Deregulated Nutrient Sensing | Although ~50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. | 22331558 |
| Breast Cancer Cell | Deregulated Nutrient Sensing | Here, we report a novel small molecule Inauhzin (INZ) that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. | 22331558 |
| Data types - Address | Deregulated Nutrient Sensing | AD may represent a brain-specific form of insulin resistance. | 22332892 |
| Polycystic Ovary Syndrome, Metabolic Syndrome X | Deregulated Nutrient Sensing | Pathophysiology of ovarian hyperthecosis remains poorly understood but the metabolic syndrome observed in most patients suggests that insulin resistance associated with high, postmenopausal LH levels, might play a role as in polycystic ovarian syndrome. | 22336524 |
| Proteinuria, Chronic Kidney Diseases | Deregulated Nutrient Sensing | With each one-unit increment of insulin resistance, the odds ratio of prevalent CKD and proteinuria were raised 1.312-fold (1.114 to 1.545) and 1.278-fold (1.098 to 1.488), respectively. | 22337909 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Markers of insulin resistance, lipid/lipoproteins, inflammatory markers, and liver fat increased with visceral adiposity in men and women with and without type 2 diabetes. | 22337910 |
| Muscle hypotonia, Mucopolysaccharidosis I | Deregulated Nutrient Sensing | We hypothesized that bed rest decreases muscle mass in older adults by blunting the EAA stimulation of MPS through reduced mTORC1 signaling and amino acid transporter expression in older adults. | 22338078 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | However, bed rest blunted the EAA-induced increase in MPS, mTORC1 signaling, and amino acid transporter protein content. | 22338078 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | We conclude that bed rest in older adults significantly attenuated the EAA-induced increase in MPS with a mechanism involving reduced mTORC1 signaling and amino acid transporter protein content. | 22338078 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The objective of this cross-sectional study was to determine effects of gender on dyslipidemia of type II diabetic patients. | 22338441 |
| Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Pattern of dyslipidemia in type II diabetic patients were estimated by computing all the four types of dyslipidemia like hypertriglyceridemia, low HDL, increased serum total cholesterol and increased serum LDL. | 22338441 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our findings demonstrate an association between changes in lipid metabolism and improvement in endothelial function in patients with diabetic dyslipidaemia treated with fenofibrate that may involve the effect of apoB-48 on endothelium-dependent vasodilator function. | 22341868 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Pitavastatin demonstrates long-term efficacy, safety and tolerability in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia. | 22345687 |
| Abnormality of mitochondrial metabolism, Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | There is growing evidence that mitochondrial dysfunction may lead to obesity and insulin resistance, which are major components of metabolic syndrome. | 22354267 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of Type 2 diabetes increased across the apolipoprotein B/apolipoprotein A-I ratio quartiles (1.0%, 1.6%, 2.9%, and 4.8% for the 1st through 4th quartiles, respectively, P < 0.001) and homeostasis model assessment-insulin resistance (HOMA2-IR) also showed an increasing tendency by quartile (P < 0.001). | 22356423 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes, unlike HNF1A-MODY, is associated with insulin resistance and a characteristic dyslipidaemia. | 22360925 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Chronic exposure to insufficient levels of magnesium (Mg) in drinking water increases the risk of magnesium deficiency and its association with hypertension, dyslipidemia and type 2 diabetes mellitus. | 22361711 |
| Demographics Domain | Deregulated Nutrient Sensing | Thus, pioglitazone decreased the sympathetic nerve traffic through the improvement of insulin resistance in DM patients with recent MI, which indicate that the sympathoinhibitory effects of pioglitazone may, at least in part, have contributed to the beneficial effects of pioglitazone. | 22361751 |
| Neoplasms | Deregulated Nutrient Sensing | AMP-activated protein kinase (AMPK) is an effector of the tumour suppressor LKB1, which regulates energy homeostasis, cell polarity, and the cell cycle. | 22363791 |
| Breast Carcinoma, Ionizing radiation | Deregulated Nutrient Sensing | Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells. | 22363791 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Ionizing radiation (IR), a widely used cancer therapy, is known to increase sestrin expression, and acutely activate AMPK. | 22363791 |
| Primary malignant neoplasm, Breast Carcinoma | Deregulated Nutrient Sensing | Our results suggest that in breast cancer cells SESN2 is associated with AMPK, it is involved in regulation of basal and IR-induced expression and activation of this enzyme, and it mediates sensitization of cancer cells to IR. | 22363791 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression. | 22364258 |
| Conn Syndrome | Deregulated Nutrient Sensing | Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients. | 22366095 |
| Conn Syndrome | Deregulated Nutrient Sensing | Primary aldosteronism (PA) patients display an increased incidence of insulin resistance. | 22366095 |
| Dyslipidemias, Blepharoptosis | Deregulated Nutrient Sensing | Dyslipidaemia, specifically atherogenic dyslipidaemia, should be considered as a possible determinant of age-related involutional blepharoptosis. | 22366541 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Compared with normal group patients, NGT group appeared decrease of pancreases first phase secretes and insulin resistance but not aggravate enough to induce type 2 diabetes. | 22368797 |
| Bicuspid aortic valve | Deregulated Nutrient Sensing | Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. | 22370592 |
| Heart Diseases | Deregulated Nutrient Sensing | Sirtuin 1 (SirT1) is a protein deacetylase of the sirtuin family, whose activation appears beneficial for cardiac diseases. | 22370592 |
| Glucose Intolerance (disease), Malignant Neoplasms, Pancreatic carcinoma | Deregulated Nutrient Sensing | Periampullary malignant neoplasms have been increasing in Japan, mainly in response to an increase in the incidences of pancreatic cancer, and glucose intolerance due to deterioration of insulin secretion is an important problem. | 22374239 |
| Hashimoto Disease, Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Carbohydrate metabolism disorders in the form of type 1 diabetes connected with an autoimmune process, as well as type 2 diabetes connected with the increase of the insulin resistance, occured in average of half of the patients with Hashimoto's thyroiditis. | 22378092 |
| Cancer-related fatigue, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Previous studies discovered dyslipidemia (DL) and decreased PON1 activity in chronic renal failure (CRF). | 22378349 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The aim of the study was to estimate changes of insulin resistance and plasma concentrations of adipokines after long-term antihypertensive treatment with telmisartan in obese hypertensive patients. | 22378488 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The effect is identified in both healthy subjects and subjects with dyslipidemia, which supports the hypothesis that n-3 PUFA can be supplemented as a primary or secondary means for preventing the development as well as the progression of atherosclerosis. | 22378734 |
| Inflammation, Heart failure | Deregulated Nutrient Sensing | Heart failure (HF) is characterized by inflammation, insulin resistance, and progressive catabolism. | 22379072 |
| Endothelium | Deregulated Nutrient Sensing | Mg is an antioxidant and calcium blocker and in space there is oxidative stress, insulin resistance, and inflammatory conditions with evidence in experimental animals of significant endothelial injuries and damage to mitochondria. | 22379366 |
| Bipolar Disorder, Diabetes Mellitus | Deregulated Nutrient Sensing | Using baseline data (2000-2004) from the Jackson Heart Study, an African American cohort from the U.S. South (N=5301), we quantified the association of subjective social status with selected cardiovascular risk factors: depressive symptoms, perceived stress, waist circumference, insulin resistance and prevalence of diabetes. | 22381684 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Independent of objective measures, subjective social status was significantly inversely associated with depressive symptoms (men and women) and insulin resistance (women). | 22381684 |
| Hypertensive disease, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The main risk factors for cardiovascular diseases were arterial hypertension (89.4%), dyslipidemia (78.3%), low high-density lipoprotein levels (84.2%) and low physical activity (64.1%). | 22382216 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertension and dyslipidemia were the common risk factors associated with cardiovascular diseases. | 22382216 |
| Inflammation, Metabolic Process, Cellular | Deregulated Nutrient Sensing | Blood triglycerides were not altered after 12 weeks of PIO 15 mg once daily in CAPD patients, but parameters of dysmetabolism were markedly improved, including insulin resistance, inflammation, and adipokine balance, suggesting that PIO could be of value for this high-risk patient group. | 22383630 |
| Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic kidney disease, insulin resistance, and incident diabetes in older adults. | 22383749 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance is a complication of advanced CKD. | 22383749 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance is less well characterized in earlier stages of CKD. | 22383749 |
| Weight decreased | Deregulated Nutrient Sensing | Intentional weight loss, primarily by improving insulin resistance, is known to decrease the need for anti-diabetic medications. | 22384240 |
| Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance is a predictor of poor response to peginterferon/ribavirin in patients infected with the chronic hepatitis C virus (HCV). | 22387529 |
| Prostate Cancer Outcomes Study, Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A large proportion of women with PCOS also exhibit insulin resistance, b-cell dysfunction, impaired glucose tolerance and/or type 2 diabetes (T2D). | 22389004 |
| Ulcerative Colitis | Deregulated Nutrient Sensing | Likewise, insulin resistance improved significantly in the IC compared with the UC group. | 22390448 |
| Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | We developed an inexpensive, culturally sensitive diabetes prevention program that resulted in weight loss, improved HbA1c, and improved insulin resistance in a high-risk Latino population. | 22390448 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Intrahepatic lipid accumulation is extremely common in obese subjects and is associated with the development of insulin resistance and diabetes. | 22394502 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These data suggest that the MGAT pathway is active and dynamically regulated in human liver and could be an important target for pharmacologic intervention for the treatment of obesity-related insulin resistance and NAFLD. | 22394502 |
| Dyslipidemias | Deregulated Nutrient Sensing | 77 men, selected on the basis of increased waist circumference (>=90 cm) and dyslipidaemia (triglycerides >=1.69 and/or high-density lipoprotein (HDL) cholesterol <1.03 mmol/litre), participated in this study. | 22396182 |
| Fatty degeneration, Skeletal muscle structure | Deregulated Nutrient Sensing | In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resistance. | 22396203 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population. | 22396741 |
| Obesity | Deregulated Nutrient Sensing | Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance. | 22397880 |
| Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | Using univariate logistic-regression analysis, we found that coronary risk factors associated with significant stenosis and high-risk plaque were dyslipidemia (P = 0.033) and current smoking (P = 0.030), respectively. | 22398672 |
| Prediabetes syndrome, Hypertension, CTCAE, Dyslipidemias, Non-Functioning Pituitary Gland Neoplasm | Deregulated Nutrient Sensing | The prevalence rates for both patients with nonfunctioning adenoma and sCS were: dyslipidemia: 161 (59%), hypertension: 147 (54%), MS: 128 (47%), prediabetes: 62 (23%), T2DM: 49 (18%), and CVD: 21 (8%). | 22398948 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Among participants free of diabetes at baseline, we found a significant positive association with both the homeostatic model assessment for insulin resistance and b-cell function per SD increase in Lp-PLA(2) activity (P values for both <0.01). | 22399516 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Lp-PLA(2) activity is positively associated with insulin resistance and predicts incident type 2 diabetes among older adults independent of multiple factors associated with diabetes pathogenesis. | 22399516 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pilot study for the evaluation of morphological and functional changes in retinal blood flow in patients with insulin resistance and/or type 2 diabetes mellitus. | 22401335 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to investigate early morphological and functional pathology in the retinal micro-circulation in patients with insulin resistance and/or type 2 diabetes mellitus (T2DM). | 22401335 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease. | 22402059 |
| Peripheral Arterial Diseases | Deregulated Nutrient Sensing | Insulin resistance and incident peripheral artery disease in the Cardiovascular Health Study. | 22402937 |
| Prediabetes syndrome, Peripheral Arterial Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Type 2 diabetes is a risk factor for peripheral artery disease (PAD), and insulin resistance is a key feature of diabetes and pre-diabetes. | 22402937 |
| Glucose Intolerance (disease), gastrointestinal | Deregulated Nutrient Sensing | The most prevalent symptoms were hearing loss(68 %), gastro-intestinal problems (59 %), exercise intolerance(54 %) and glucose intolerance (52 %). | 22403016 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Impact of family history of diabetes on b-cell function and insulin resistance among Chinese with normal glucose tolerance. | 22404096 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes. | 22408591 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | The associations between inflammation, diabetes and insulin resistance remain controversial. | 22409372 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | No association was found between IL-1b levels and all diabetes and insulin resistance markers studied. | 22409372 |
| TNF protein, human, Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | We found that subjects with diabetes, metabolic syndrome and increased insulin resistance had increased levels of IL6, TNF-a and hs-CRP, while no association was found with IL-1b. | 22409372 |
| Hyperglycemia | Deregulated Nutrient Sensing | Postoperative insulin resistance and the consequent hyperglycemia affects clinical outcome. | 22409999 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | The secular changes presage increases in the prevalence of conditions associated with childhood and adolescent obesity-such as hypertension, glucose intolerance, and dyslipidemia-that may appear as early as the second decade of life. | 22410970 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Variants of the high-mobility group A1 (HMGA1) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. | 22411136 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Haiti | Deregulated Nutrient Sensing | 13% were type 2 diabetics, 23% had HT and 40% had dyslipidemia. | 22411383 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The incidence of cardiovascular risk factors in the subjects studied is higher in DM (13%), similar to general population in terms of dyslipidemia (40%) and obesity (23%) and lowest in hypertension (23%). | 22411383 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | It is thought that adipose tissue, particularly visceral fat, which secretes systemic factors that alter immunological, metabolic and endocrine milieu and promotes insulin resistance by producing adipocytokines, is important in cancer progression. | 22411584 |
| Renal Insufficiency, Postoperative Complications, anemia acute | Deregulated Nutrient Sensing | Cardiac revascularization with extracorporeal circulation is characterized by marked postoperative complications such as insulin resistance, a pro-inflammatory state, acute anemia and renal dysfunction. | 22414875 |
| Inflammation, Breast Carcinoma, Obesity | Deregulated Nutrient Sensing | The influence of obesity, vitamin-D status, insulin resistance, inflammation, and elevated adipocytokines in women at high risk of breast cancer is unknown. | 22415479 |
| deficiency aspects, Diabetes Mellitus | Deregulated Nutrient Sensing | Androgen deficiency in adipocytes in mice resembles human type 2 diabetes, with early insulin resistance and evolving insulin deficiency. | 22415878 |
| Hyperglycemia | Deregulated Nutrient Sensing | The relationships between vitamin D concentrations, hyperglycemia, and insulin resistance remain uncertain. | 22419202 |
| Thrombocytopenia, Dyslipidemias, Osteoporosis, Allergy - Charge Type Reason | Deregulated Nutrient Sensing | Unfractionated heparin (UFH) is the standard anticoagulant in regular dialysis treatments (RDTs), despite the fact that it may induce thrombocytopenia, dyslipidemia, allergy and osteoporosis. | 22419236 |
| Dysglycemia, Sarcopenia | Deregulated Nutrient Sensing | Sarcopenia exacerbates obesity-associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. | 22421977 |
| Sarcopenia, Obesity | Deregulated Nutrient Sensing | Sarcopenia often co-exists with obesity, and may have additive effects on insulin resistance. | 22421977 |
| Increased insulin level, Impaired cognition | Deregulated Nutrient Sensing | Hyperinsulinemia, insulin resistance and cognitive decline in older cohort. | 22424621 |
| Increased insulin level, AKAP4 protein, human, Data types - Address | Deregulated Nutrient Sensing | But the roles of hyperinsulinemia (HI) and insulin resistance (IR) in the development of AD are still controversial. | 22424621 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance. | 22424624 |
| Inflammation | Deregulated Nutrient Sensing | High fat diets increase the risk for insulin resistance by promoting inflammation. | 22424821 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated IgG levels against specific bacterial antigens in obese patients with diabetes and in mice with diet-induced obesity and glucose intolerance. | 22424821 |
| Ischemia, Atrial Fibrillation by ECG Finding, Dyslipidemias, Edema, Heart failure, Ischemic stroke, Hemiplegia, Atrial Fibrillation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In the multivariate analysis, variables related to mortality in acute ischemic stroke were age, chronic renal failure, dyslipidemia, history of heart failure, atrial fibrillation (AF), presenting as hemiplegia, signs of acute ischemia and perilesional edema in the brain scan on hospital admission. | 22425144 |
| Sensorineural Hearing Loss (disorder), Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Of the three lifestyle-related diseases hypertension, dyslipidemia, and diabetes, only diabetes was significantly associated with SSNHL risk. | 22426290 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Genetic variability of the major subunit (CACNA1E) of the voltage-dependent Ca(2+) channel Ca(V)2.3 is associated to risk of type 2 diabetes, insulin resistance and impaired insulin secretion in nondiabetic subjects. | 22427875 |
| Cessation of life | Deregulated Nutrient Sensing | Insulin resistance measured as ISI or fasting insulin concentration is associated with increased risk of death among older adults, adjusting for conventional confounding characteristics. | 22432118 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Statistically significant lower SctO(2) values were observed in patients with diabetes (P=.026; confidence interval [CI], 0.006-0.090) and in patients with dyslipidemia (P=.007; CI, 0.018-0.103). | 22432554 |
| Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Of these patients, 76% had preoperative co-morbidities, including insulin resistance in 59.2%, dyslipidemia in 23.5%, hepatic steatosis in 16%, and type 2 diabetes mellitus in 3.9%. | 22433934 |
| Depressed mood | Deregulated Nutrient Sensing | A neural circuitry linking insulin resistance to depressed mood. | 22434915 |
| Depressed mood, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) confers risk for Type 2 diabetes and is associated with depressed mood. | 22434915 |
| Dyslipidemias, Coronary Arteriosclerosis, Obesity, Hypertension, CTCAE, Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | Glycemic control, dyslipidemia, hypertension, obesity, diabetic complications and atherosclerotic disease were measured annually. | 22435936 |
| Dyslipidemias, Diabetes Mellitus, diabetic, Hypertension, CTCAE, Mental deterioration | Deregulated Nutrient Sensing | The results suggest that comprehensive management of diabetes, including dyslipidemia and hypertension, might contribute to the prevention of declines in cognitive function in older diabetic patients. | 22435946 |
| Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | The most common co-morbid conditions were insulin resistance 55.1%, dyslipidemia 45.5%, arterial hypertension 23.1%, hypothyroidism 15.4% and non-alcoholic fatty liver disease 12%. | 22438219 |
| Neoplasms | Deregulated Nutrient Sensing | When Sirtuin 1 was less than 1 pg, the majority of the people had various degrees of tumors or other serious diseases. | 22443029 |
| Acquired Immunodeficiency Syndrome | Deregulated Nutrient Sensing | When Sirtuin 1 levels were less than 0.25 pg BDORT units, a high incidence of AIDS was also detected. | 22443029 |
| Venous Thromboembolism | Deregulated Nutrient Sensing | Insulin resistance and risk of venous thromboembolism: results of a population-based cohort study. | 22443091 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance has a central role in the pathophysiology of the metabolic effects of obesity. | 22443091 |
| vinyltriethoxysilane | Deregulated Nutrient Sensing | We aimed to investigate whether insulin resistance is a risk factor for VTE. | 22443091 |
| vinyltriethoxysilane | Deregulated Nutrient Sensing | Our population-based cohort study shows an increased risk of VTE in subjects with increasing insulin resistance but not independently of BMI. | 22443091 |
| Data types - Address | Deregulated Nutrient Sensing | As insulin resistance is reported to be a risk factor for sporadic AD, this PS1-mediated regulatory mechanism of brain insulin signaling may be causally associated with AD pathology. | 22443192 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | In contrast, nuclear vacuolation was present in all patients with liver disease, ranging from 0.1% to 11.7% hepatocytes, irrespective of the aetiology of liver disease and independent of insulin resistance. | 22447919 |
| Injury of liver | Deregulated Nutrient Sensing | Nuclear vacuolation in hepatocytes is a marker of senescence and likely to be a consequence of liver injury, unrelated to insulin resistance. | 22447919 |
| square decimeter | Deregulated Nutrient Sensing | In patients with DM2, pancragen significantly decreased glucose level on an empty stomach and in standard glucose tolerance test and reduced plasma concentrations of insulin and insulin resistance index. | 22448364 |
| Hypoxia | Deregulated Nutrient Sensing | In this study, we provide new evidence indicating that overexpression of SirT1 in hepatoma HepG2 cells allowed the cells to become much more resistant to irradiation under hypoxia than under normoxia. | 22448750 |
| Hypoxia | Deregulated Nutrient Sensing | When SirT1 was knocked down in both HepG2 and SK-Hep-1 cells, the radiosensitivity was increased, especially under hypoxia. | 22448750 |
| Radiation Damage | Deregulated Nutrient Sensing | SirT1 could serve as a novel target of radiation damage and thus as a potential strategy to advance the efficiency of radiotherapy in hepatoma entities. | 22448750 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | to compare the effectiveness of metformin and pioglitazone in ameliorating insulin resistance and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). | 22451180 |
| Primary malignant neoplasm, Dyslipidemias, No metabolic abnormalities, Obesity | Deregulated Nutrient Sensing | Vascular health in cancer survivors may be further compromised by metabolic abnormalities such as obesity, insulin resistance, and dyslipidemias which have also been reported following cancer therapy. | 22456863 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | The results of our study indicate that increased Hcy levels are related mostly with abdominal obesity and with insulin resistance. | 22460264 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia is a cardiometabolic risk factor for the development of type 2 diabetes mellitus. | 22462348 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. | 22464806 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Insulin resistance is one of the most common features of polycystic ovary syndrome (PCOS). | 22464806 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Some studies suggest that vitamin D deficiency may have a role in insulin resistance; thus, the aim of the current study was to determine the effect of vitamin D supplementation on insulin resistance in women with PCOS and a vitamin D deficiency. | 22464806 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | We hypothesized that vitamin D supplementation would lower the glucose level and insulin resistance in women with PCOS and a vitamin D deficiency. | 22464806 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | We were not able to demonstrate the effect of vitamin D supplementation on insulin sensitivity and insulin resistance in women with PCOS and vitamin D deficiency. | 22464806 |
| GDC AJCC Clinical Stage Terminology, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Multiple logistic analysis showed that the largest risk factor for developing ACS was given by smoking habit, diabetes, hypertension, dyslipidemia, and the TGF-b1 29 TT genotype. | 22465044 |
| Carcinogenic Chlorinated Hydrocarbon, Lesion of liver, Hepatitis C, Liver Cirrhosis | Deregulated Nutrient Sensing | The results showed that various types of chronic viral hepatitis C and stages of cirrhosis set to increase HOMA-IR versus the controls., which were the most prominent in cases of severe hepatic lesion, which indicates that insulin resistance is a frequent companion of CHC. | 22466538 |
| Kidney Calculi | Deregulated Nutrient Sensing | Associations of insulin resistance and glycemic control with the risk of kidney stones. | 22466823 |
| Kidney Calculi | Deregulated Nutrient Sensing | The associations of insulin resistance and glycemic control with the risk of kidney stones were explored. | 22466823 |
| Kidney Calculi | Deregulated Nutrient Sensing | The significant associations between glycemic control measures and the risk of kidney stones were preserved even after the adjustment for factors related to insulin resistance. | 22466823 |
| Neoplasm Metastasis, Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. | 22470132 |
| Cardiovascular Physiological Phenomena, Diabetes Mellitus, Disease, Nerve Degeneration | Deregulated Nutrient Sensing | SIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration. | 22470132 |
| Neoplasms | Deregulated Nutrient Sensing | However, accumulating evidence shows that SIRT1 is overexpressed in various types of malignant cells, and its inhibitors suppress the growth of tumor cells. | 22470132 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | The relationship between SIRT1 and metastasis remains to be clarified. | 22470132 |
| Neoplasm Metastasis, Breast Carcinoma | Deregulated Nutrient Sensing | Here, we examined the effect of SRT1720, a SIRT1 activator, on lung metastasis of breast cancer cells. | 22470132 |
| Secondary malignant neoplasm of lung, Neoplasm Metastasis, Breast Carcinoma | Deregulated Nutrient Sensing | These findings imply that SRT1720 promotes the pulmonary metastasis of breast cancer cells and SIRT1 may be an important target for suppressing metastasis to the lung. | 22470132 |
| Hypertension, CTCAE, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Previously she had been treated for hypothyroidism, hypertension, and dyslipidemia. | 22471430 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, dyslipidemia frequency showed a complex pattern of an initial decline and then an increase. | 22474244 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Even though the practice guideline has been launched since 2008, diabetes, hypertension and dyslipidemia were still poorly controlled. | 22475634 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects without dyslipidemia and intron 4 a/b genotype present a lower chance for ACS development, whereas subjects without diabetes and 894TT genotype show a higher risk for ACS (OR 1.7; 95% CI 1.2-2.3). | 22475779 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | In patients without dyslipidemia, the 894GG genotype presented a tendency to behave as a protector factor against ACS. | 22475779 |
| Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | Although a connection between AD and diabetes has been suggested, a major unknown is the mechanism(s) by which insulin resistance in the brain arises in individuals with AD. | 22476196 |
| Alzheimers Disease", Impaired cognition | Deregulated Nutrient Sensing | Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. | 22476197 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder. | 22476197 |
| Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | In the HF, these candidate biomarkers of brain insulin resistance increased commonly and progressively from normal cases to mild cognitively impaired cases to AD cases regardless of diabetes or APOE e4 status. | 22476197 |
| Impaired cognition, Data types - Address, physiopathological | Deregulated Nutrient Sensing | Brain insulin resistance thus appears to be an early and common feature of AD, a phenomenon accompanied by IGF-1 resistance and closely associated with IRS-1 dysfunction potentially triggered by Ab oligomers and yet promoting cognitive decline independent of classic AD pathology. | 22476197 |
| Sleep Apnea, Obstructive, Obesity | Deregulated Nutrient Sensing | Risk for obstructive sleep apnea in obese, nondiabetic adults varies with insulin resistance status. | 22481243 |
| Osage language | Deregulated Nutrient Sensing | Surrogate estimates of insulin resistance based on fasting insulin, triglycerides, and/or HDL-C can be used to help identify those obese adults who would benefit most from OSA screening and referral for polysomnography. | 22481243 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In this sample, 11/30 (36.67%) had high blood pressure, 5/30 (16.67%) had diabetes mellitus, 6/30 (20%) had dyslipidemia and 2/30 (6.67%) were smokers. | 22481700 |
| Dyslipidemias | Deregulated Nutrient Sensing | Frequency of dyslipidemia increased up to 65 years, except for low high-density lipoprotein cholesterol which did not vary with age. | 22483404 |
| Thrombosis, Atherosclerosis | Deregulated Nutrient Sensing | Adipose tissue may release mediators that induce a chronic inflammatory state and alterations in coagulation, which contribute to insulin resistance, atherosclerosis, and thrombosis. | 22484367 |
| Obesity | Deregulated Nutrient Sensing | These are labelled obesity, lipids, insulin resistance and blood pressure. | 22485169 |
| Obesity | Deregulated Nutrient Sensing | The exploratory factor analysis with oblique rotation suggested an overlap of the loadings identified on the insulin resistance and obesity factors. | 22485169 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The main study found that, compared with usual care, addition of a pharmacist resulted in improvements in blood pressure, dyslipidaemia, and hyperglycaemia for primary care patients with Type 2 diabetes. | 22486226 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | We aimed to characterize the association of insulin resistance, impaired insulin secretion and b-cell dysfunction in relation to HbA(1c) levels in a non-diabetic range in Japanese individuals without clinically diagnosed diabetes. | 22486679 |
| Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | [Association between serum adipocyte fatty acid binding protein level and dyslipidemia in patients with obstructive sleep apnea syndrome]. | 22490689 |
| Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | To explore the association between serum adipocyte fatty acid binding protein (A-FABP) levels and dyslipidemia in patients with obstructive sleep apnea syndromes (OSAS). | 22490689 |
| Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and elevated level of serum A-FABP are common in OSAS patients. | 22490689 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The independent risk factors of T2DM was dyslipidemia (HR = 1.459; 95%CI: 1.027 - 2.072, P < 0.05) and hypertension (HR = 1.516; 95%CI: 1.039 - 2.212, P < 0.05) based upon the COX's proportional hazard analysis. | 22490691 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia (HR = 1.545; 95%CI: 1.087 - 2.195, P < 0.05) and hypertension (HR = 1.524; 95%CI: 1.044 - 2.224, P < 0.05) were also independent risk factors of abnormal glycometabolism (T2DM and IGR). | 22490691 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | According to multivariate analysis, hypertension and dyslipidemia are independent risk factors of T2DM and abnormal glycometabolism (T2DM and IGR). | 22490691 |
| Dyslipidemias | Deregulated Nutrient Sensing | hsCRP increased in proportion with the degree of dyslipidemia. | 22490712 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | A weak positive correlation between TG and hsCRP as well as a weak negative correlation between HDL-C and hsCRP was evidenced in the whole cohort suggesting dyslipidemia might be related to enhanced inflammatory status. | 22490712 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Performance of a multi-marker diabetes risk score in the Insulin Resistance Atherosclerosis Study (IRAS), a multi-ethnic US cohort. | 22492485 |
| Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | This study compares a previously developed Diabetes Risk Score to commonly used clinical tools for type 2 diabetes risk evaluation in the Insulin Resistance Atherosclerosis Study (IRAS) cohort, a multi-ethnic US cohort. | 22492485 |
| Hypertension, CTCAE, Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance in patients with cirrhosis and portal hypertension. | 22492691 |
| Endothelial dysfunction, Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance (IR) is involved in the pathogenesis of endothelial dysfunction and is also present in patients with cirrhosis. | 22492691 |
| Obesity | Deregulated Nutrient Sensing | Rodent data show that altered hypothalamic signaling contributes to the development of obesity and insulin resistance. | 22492775 |
| Obesity | Deregulated Nutrient Sensing | Increased adipose tissue lipolytic activity is considered an important factor in the pathogenesis of skeletal muscle insulin resistance associated with obesity. | 22492868 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | T2D is primarily characterized by insulin resistance, and growing evidence has indicated the causative link between adipose tissue inflammation and the development of insulin resistance. | 22499789 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | We found CD44 deficiency in a diabetic mouse model ameliorates insulin resistance and adipose tissue inflammation and also found that anti-CD44 antibody treatment decreases blood glucose levels and adipose tissue macrophage accumulation in a high-fat, diet-fed mouse model. | 22499789 |
| Sleep-Disordered Breathing, Diabetes Mellitus | Deregulated Nutrient Sensing | SDB is independently related to the development of insulin resistance and, thereby, the risk of manifest diabetes mellitus. | 22499826 |
| Best Case Imputation Technique, Dyslipidemias, diabetic, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | The studied sample had a subset of high-risk of BC featured by postmenopausal overweight and diabetic women, who also had a personal history of hypertension and/or dyslipidemia. | 22502657 |
| GDC Disease Response Terminology, Dyslipidemias, Coronary Artery Disease, Cerebrovascular accident | Deregulated Nutrient Sensing | In comparison to no-DR, DR patients were older and more likely to have high prevalence of dyslipidemia, coronary artery disease and cerebrovascular accidents. | 22502915 |
| Ventricular hypertrophy | Deregulated Nutrient Sensing | The relationship of visfatin levels with insulin resistance and left ventricular hypertrophy in peritoneal dialysis patients. | 22503095 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Factors significantly and independently associated to CKD were older age, hypertension and dyslipidemias. | 22503754 |
| Dysglycemia | Deregulated Nutrient Sensing | High incidence of insulin resistance and dysglycemia amongst nondiabetic cardiac surgical patients. | 22503851 |
| Dysglycemia | Deregulated Nutrient Sensing | Preoperative insulin resistance, not FBG, is significantly associated with the development of perioperative dysglycemia. | 22503851 |
| Dysglycemia | Deregulated Nutrient Sensing | Insulin resistance screening may be useful to identify insulin resistance preoperatively and predict the degree of perioperative dysglycemia in cardiac surgical patients but should be performed with a more appropriate and reproducible test. | 22503851 |
| Rheumatoid Arthritis, Dyslipidemias, Necrosis | Deregulated Nutrient Sensing | Dyslipidemia and changes in lipid profiles associated with rheumatoid arthritis and initiation of anti-tumor necrosis factor therapy. | 22504829 |
| Refractory anemias, Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | To investigate the frequency of lipid testing in clinical practice and to explore the relationship between rheumatoid arthritis (RA), dyslipidemia, and other cardiovascular (CV) risk factors with RA treatment. | 22504829 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | In obesity, adipose tissue becomes a significant source of chemokines and inflammatory cytokines that are associated with chronic systemic low-grade inflammation and may lead to insulin resistance. | 22508338 |
| Inflammation, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes. | 22509446 |
| Inflammation, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Based on our recent findings on persistent organic pollutants (POPs) including the lack of an association between obesity and either insulin resistance or diabetes prevalence among subjects with very low concentrations of POPs, we hypothesized that POP concentrations may be associated with inflammation and modify the associations between inflammation and insulin resistance in non-diabetic subjects. | 22509446 |
| Inflammation | Deregulated Nutrient Sensing | In the current study, OC pesticides were associated with increased levels of CRP, a marker of inflammation, and both OC pesticides and PCBs may also modify the associations between CRP and insulin resistance. | 22509446 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In view of recent guidelines for the clinical management of dyslipidemia recommending the monitoring of non-HDL cholesterol as a secondary target after achieving the low-density lipoprotein (LDL) cholesterol goal, we aimed to assess the association of non-HDL cholesterol with incident type 2 diabetes and compare its utility as a risk predictor with traditional lipid variables in Aboriginal Canadians. | 22510237 |
| Hypertensive disease, Increased insulin level, Hypertension, CTCAE | Deregulated Nutrient Sensing | Although hyperinsulinemia, a surrogate of insulin resistance, may play a role in the pathogenesis of hypertension (HTN), the longitudinal association between fasting insulin level and HTN development is still controversial. | 22511258 |
| Adrenal Gland Neoplasms, Cardio-Renal Syndrome, Eyelid Xanthoma, Dyslipidemias, Delusions, CTCAE | Deregulated Nutrient Sensing | Additional examinations and consultations demonstrated dyslipidemia, xanthelasma, incomplete block of the right branch of His bundle, thyreocardiac syndrome, benign adrenal tumor, and delusions. | 22515675 |
| Dyslipidemias, Ulcer, Diabetes Mellitus, Retinal Diseases, Cerebrovascular Disorders, Diabetic peripheral neuropathy, Hypertension, CTCAE | Deregulated Nutrient Sensing | Multivariate analysis revealed that age, female sex, diabetes duration, lower glycated haemoglobin, treatment with oral hypoglycaemic agents or insulin, presence of retinopathy, history of cerebrovascular or peripheral arterial disease, presence of hypertension or dyslipidaemia, and history of foot ulcer were independently associated with diabetic peripheral neuropathy. | 22519862 |
| Hyperglycemia, Dyslipidemias, Anemia, Hypoalbuminemia, Kidney Failure | Deregulated Nutrient Sensing | Men had higher scores both for BI (70 -SD 34.4- vs. 50.4 -SD 36.6-, P = .005) and CME (16.5 -SD 9.1- vs. 9.1 -SD 11.6-, P = .008); 40.3% of the centenarians had anaemia, 67.5% renal failure, 13% hyperglycaemia, 22.1% hypoalbuminaemia and 10.7% dyslipidaemia, without statistically significant differences regarding sex. | 22520618 |
| Hepatitis C, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: implications for type 2 diabetes. | 22520843 |
| Hepatitis C | Deregulated Nutrient Sensing | Individuals with a definitive diagnosis of chronic hepatitis C and insulin resistance were eligible for participation. | 22520843 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | BCAA therapy did not have adverse effects on glucose tolerance or insulin sensitivity in patients with chronic hepatitis C and insulin resistance. | 22520843 |
| Cell secretion, Diabetes Mellitus | Deregulated Nutrient Sensing | A parental history for diabetes markedly affects residual insulin secretion and secretory loss rate in T2DM offspring without worsening insulin resistance. | 22521319 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The prevalence was high in participants with dyslipidemia (70.4%), hypertension (56.8%), and obesity (53%). | 22521729 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | Glucose intolerance is frequently associated with an altered plasma lipid profile and increased cardiovascular disease risk. | 22522760 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | This finding suggests that the dissociation of free cholesterol from lipoprotein particles occurs in normolipidemic glucose intolerance and may participate in atherogenic signaling. | 22522760 |
| Triglycerides to HDL Cholesterol Ratio Measurement, IFNG wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Among subjects without diabetes or IFG, a third showed a high triglycerides/HDL-cholesterol ratio, indicating insulin resistance. | 22523842 |
| Obesity, Abdominal, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that the Canarian-Venezuelan community suffers high prevalence of cardiovascular risk factors (obesity, abdominal obesity, dyslipidemia, diabetes). | 22523842 |
| Reduced Device Function, Microalbuminuria, Dyslipidemias, Diabetes Mellitus, Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | They also had more frequently diabetes, dyslipidemia, reduced renal function, microalbuminuria, left-ventricular hypertrophy and previous history of cardiovascular events. | 22525201 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of type 2 diabetes mellitus (T2DM), hypertension and dyslipidemia were recorded. | 22527598 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | Dyslipidemia was seen in 7.3 % of hyperuricemic patients as compared to 5.8 % of the normouricemic subjects. | 22527598 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | There was no significant correlation between the occurrence of T2DM and dyslipidemia and hyperuricemia. | 22527598 |
| Thrombophilia, Cardiovascular Diseases, Atherosclerosis, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. | 22527619 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis. | 22527884 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results indicated that genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin resistance in Chinese. | 22527884 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Insulin resistance and adipose-derived hormones in young men with untreated obstructive sleep apnea. | 22528956 |
| Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | Obstructive sleep apnea (OSA) increases the risk for insulin resistance (IR). | 22528956 |
| Dyslipidemias, Failure (biologic function) | Deregulated Nutrient Sensing | The failure of therapy with oral hypoglycemic drugs leads to not only poorly regulated glycemic status, but also dyslipidemia and increased body weight and body mass index (BMI). | 22533711 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Metabolic risk factors (obesity, arterial hypertension, dyslipidemia) were highly prevalent in the study patients, and these factors were more prevalent among women. | 22534719 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity, hypertension, and dyslipidemia were more prevalent among women. | 22534719 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factor control in German patients was inadequate (control rates: hypertension 36.3%, dyslipidemia 30.4%, type 2 diabetes 40.6%, obesity 28.8%) but largely comparable to other ROE countries; however, physicians tended to overestimate control rates. | 22536072 |
| Obesity | Deregulated Nutrient Sensing | Among the subjects studied, circulating chemerin levels were associated with obesity markers but not with markers of insulin resistance. | 22544171 |
| Ischemia, Hypertrophy | Deregulated Nutrient Sensing | In the heart, intrinsic activation of the AMP-dependent protein kinase (AMPK) plays a pivotal role in the stress response to ischemia and hypertrophy. | 22546364 |
| Obesity | Deregulated Nutrient Sensing | The purpose of the present study was to investigate the influence of obesity and aging on the AMPK signaling pathway in human cardiac tissue. | 22546364 |
| Refractory anemias | Deregulated Nutrient Sensing | Right atrial tissue (RA) was analyzed for the expression of the AMPK upstream kinases CAMKK and LKB1, activation of AMPK as well as phosphorylation of the AMPK downstream targets ACC, eEF2, mTOR and eNOS. | 22546364 |
| Refractory anemias, Obesity | Deregulated Nutrient Sensing | Despite the low total serum adiponectin and HMW adiponectin, AMPK activation was high in the RA of obese patients (YO, OO). | 22546364 |
| Obesity | Deregulated Nutrient Sensing | These data indicate that obesity and aging result in significant changes although many direct parameters in the AMPK signaling pathway are not changed in the same direction. | 22546364 |
| Pulmonary Emphysema | Deregulated Nutrient Sensing | SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. | 22546858 |
| ARCN1 gene | Deregulated Nutrient Sensing | Anti-aging sirtuin 1 (SIRT1), a NAD+-dependent protein/histone deacetylase, is reduced in lungs of patients with COPD. | 22546858 |
| Hypertrophy, Impaired lung function | Deregulated Nutrient Sensing | Ablation of Sirt1 in airway epithelium, but not in myeloid cells, aggravated airspace enlargement, impaired lung function, and reduced exercise tolerance. | 22546858 |
| Inflammation, Pulmonary Emphysema | Deregulated Nutrient Sensing | Thus, SIRT1 protects against emphysema through FOXO3-mediated reduction of cellular senescence, independently of inflammation. | 22546858 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Chronic low-grade inflammation is crucial for the development of insulin resistance and type 2 diabetes mellitus (T2DM), and immunocompetent cells, such as T-cells, B-cells, mast cells and macrophages, regulate the pathogenesis of T2DM. | 22547395 |
| Obesity | Deregulated Nutrient Sensing | Bariatric surgery is an additional option in the treatment of obesity and insulin resistance. | 22549255 |
| Inflammation | Deregulated Nutrient Sensing | Changes in biomarkers linked to insulin resistance and inflammation were not observed. | 22549511 |
| Liver carcinoma | Deregulated Nutrient Sensing | SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. | 22552445 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | Overexpression of SIRT1 in cancer tissue, compared with normal tissue, has been demonstrated, suggesting that SIRT1 may act as a tumor promoter. | 22552445 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The function of SIRT1 in liver cancer has not been elucidated. | 22552445 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | The results demonstrate that SIRT1 promotes tumorigenesis of hepatocellular carcinoma (HCC) through the PTEN/PI3K/AKT signaling pathway. | 22552445 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | SIRT1 may serve as a novel target for selective killing of cancer versus normal liver cells. | 22552445 |
| Carcinogenesis, Pancreatic carcinoma | Deregulated Nutrient Sensing | Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer. | 22552606 |
| Adenocarcinoma of pancreas | Deregulated Nutrient Sensing | Methylation of HIC1 promoter HIC1 and SIRT1 expression were detected in human normal pancreas (NP), CP and pancreatic adenocarcinoma tissues. | 22552606 |
| Carcinogenesis | Deregulated Nutrient Sensing | Our results indicate that hypermethylation of HIC1 promoter in CP may contribute to the aberrant expression of HIC1/SIRT1 pathway and then involve in the pancreatic carcinogenesis. | 22552606 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes. | 22552911 |
| Beta-cell dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. | 22552911 |
| Blood Glucose | Deregulated Nutrient Sensing | In conclusion, the levels of branched-chain, aromatic amino acids and alanine increased and the levels of glutamine and histidine decreased with increasing glycemia, reflecting, at least in part, insulin resistance. | 22553379 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Colorectal cancer (CRC) is associated with lifestyle factors that affect insulin/IGF signaling, of which the insulin receptor substrate 1 (IRS1) is a key transducer. | 22558377 |
| Neoplasms | Deregulated Nutrient Sensing | Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. | 22560924 |
| nervous system disorder, Cachexia, Obesity | Deregulated Nutrient Sensing | This assay will be valuable for investigating neurological and cardiac diseases and states of cachexia, insulin resistance, and obesity. | 22561185 |
| Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | Notably, suppression of RGS4-dependent glioma cell invasion was signaled through both mTOR complexes, mTORC1 and mTORC2, in a concentration-dependent manner, indicating that high doses of CCI-779 may overcome tumor-cell resistance associated with the sole inhibition of mTORC1. | 22562250 |
| Myocardial Ischemia, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | These data add evidence to support a causal link between increased BMI and IHD risk, though the mechanism may ultimately be through intermediate factors like hypertension, dyslipidemia, and type 2 diabetes. | 22563304 |
| Inflammation | Deregulated Nutrient Sensing | Relationships between sarcopenic obesity and insulin resistance, inflammation, and vitamin D status: the Korean Sarcopenic Obesity Study. | 22563924 |
| Inflammation, Sarcopenia, Obesity | Deregulated Nutrient Sensing | It has been suggested that insulin resistance, low-grade inflammation and vitamin D deficiency are associated with obesity and sarcopenia. | 22563924 |
| Inflammation | Deregulated Nutrient Sensing | Insulin resistance, inflammation and vitamin D deficiency were associated with SO in a Korean adult population. | 22563924 |
| Dyslipidemias | Deregulated Nutrient Sensing | At least one dyslipidemia was present in 50.8% of all patients and in 71.1% of high-risk patients. | 22566746 |
| Dyslipidemias | Deregulated Nutrient Sensing | Among all subjects with any dyslipidemia, 30.9% had mixed dyslipidemias and 69.4% had low HDL-C and/or elevated triglycerides, while 30.6% had isolated elevated LDL-C; corresponding values for high-risk patients were 36.8%, 58.9%, and 41.1%. | 22566746 |
| Dyslipidemias | Deregulated Nutrient Sensing | Mixed dyslipidemias in primary care patients in France. | 22566746 |
| Dyslipidemias | Deregulated Nutrient Sensing | Oral carnitine supplementation for dyslipidemia in chronic hemodialysis patients. | 22569432 |
| Dyslipidemias | Deregulated Nutrient Sensing | Carnitine deficiency is a commonly observed problem in maintenance hemodialysis (MHD) patients, which results in altered metabolism of fatty acids and subsequently development of dyslipidemia. | 22569432 |
| Hyperthyroidism, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Carvedilol might be a preferred agent to treat hyperthyroid patients who have hypertension and dyslipidemia. | 22571552 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | This is likely due to insulin resistance of protein metabolism and/or endothelial dysfunction with a reduction in nutritive flow, both of which can be improved by aerobic exercise. | 22572647 |
| Obesity | Deregulated Nutrient Sensing | Association of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults. | 22573135 |
| Obesity | Deregulated Nutrient Sensing | The aim of this study was to determine whether low levels of OCN would be associated with insulin resistance, obesity, and greater cardiovascular (CV) risk in young adults just emerging from adolescence. | 22573135 |
| Obesity | Deregulated Nutrient Sensing | However, the significant associations of OCN with SBP, obesity, and adiponectin and borderline with M(lbm), suggest a potential role for OCN in the development of insulin resistance and CV risk that becomes more apparent with aging into older adulthood. | 22573135 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was a high prevalence of diabetes, hypertension, dyslipidemia and current smoking. | 22574544 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Multivariate statistic analysis supports a relation with older age, female gender, dyslipidemia and heart disease. | 22575556 |
| Non-alcoholic Fatty Liver Disease, Liver carcinoma, Liver Cirrhosis, Obesity | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. | 22576780 |
| Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | Sleep duration is associated with dyslipidemia in patients with bipolar disorder in clinical remission. | 22578889 |
| Inflammation, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Although previous studies have suggested associations between plasma palmitoleic acid and coronary heart disease (CHD) risk factors, including blood pressure, inflammation, and insulin resistance, little is known about the relation of palmitoleic acid and CHD. | 22579341 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Overweight and dyslipidemia were significantly more frequent in women (P<0.001), while smoking and physical inactivity were significantly more frequent in men (P<0.001). | 22579490 |
| Dyslipidemias, Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | During the period, there was a moderate rise of the prevalence of overweight, dyslipidemia, and physical inactivity, whereas the prevalence of diabetes and smoking remained almost unchanged. | 22579490 |
| Arterial Stiffness, Dyslipidemias | Deregulated Nutrient Sensing | Reduced mortality in patients with sevelamer HCl may, at least in part, be explained by an improvement in dyslipidemia and arterial stiffness by sevelamer HCl. | 22581064 |
| Acute myocardial infarction, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Recent studies have demonstrated that newly diagnosed glucose intolerance is common among patients with acute myocardial infarction (AMI). | 22581733 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Although second-generation antipsychotics were associated with dyslipidemia and insulin resistance, they were not associated with vasculopathy. | 22584147 |
| Heart failure | Deregulated Nutrient Sensing | Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. | 22586279 |
| Heart failure | Deregulated Nutrient Sensing | Systemic insulin resistance in heart failure was accompanied by decreased myocardial triglyceride and overall fatty acid content but increased toxic lipid intermediates, diacylglycerol, and ceramide. | 22586279 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians. | 22586585 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Results show that although multiple SNPs showed marginal individual association with insulin resistance and type 2 diabetes, only a few can pass adjustment for multiple testing. | 22586585 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | However, a gene-family analysis considering the joint impact of all 61 SNPs reveals significant association of the nAChR gene family with both insulin resistance and type 2 diabetes (both P < 0.0001), suggesting that genetic variants in the nAChR genes jointly contribute to insulin resistance and type 2 diabetes among American Indians. | 22586585 |
| Addison Disease, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | BClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidaemia in patients with Addison's disease. | 22587831 |
| Addison Disease, Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that BclI polymorphism may influence the sensitivity to glucocorticoids in patients with Addison's disease and may contribute, along with other factors, to the increase in central adiposity, impaired glucose metabolism and dyslipidaemia. | 22587831 |
| melanoma | Deregulated Nutrient Sensing | Raf/MEK/ERK signaling can inhibit the liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway, thus rendering melanoma cells resistant to energy stress conditions. | 22588166 |
| melanoma | Deregulated Nutrient Sensing | Nine melanoma cell lines were treated with the AMPK activators 5-aminoimidazole-4-carboxamide-ribonucleoside (AICAR) and phenformin. | 22588166 |
| Schizophrenia, Dyslipidemias | Deregulated Nutrient Sensing | Antipsychotic-treated schizophrenia patients are susceptible to dyslipidemia. | 22591814 |
| Hypertensive disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Through Chi-square significant differences (P=0.00001-0.03874) between specific ethnic groups for all four PAD-related risk factors (i.e., HTN, dyslipidemia, diabetes and cigarette smoking). | 22608174 |
| Hypertensive disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | All of the associations between the prevalence of HTN, dyslipidemia, diabetes, or cigarette smoking and ethnicity were statistically significant (P=<0.0001). | 22608174 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | They were more likely to be morbidly obese (32% versus 9%), have dyslipidemia (25% versus 6%), or have hypertension (53% versus 38%; P < 0.01). | 22611040 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Insulin resistance undermines the advantages of IL28B polymorphism in the pegylated interferon alpha-2b and ribavirin treatment of chronic hepatitis C patients with genotype 1. | 22613000 |
| Communicable Diseases, Hepatitis C | Deregulated Nutrient Sensing | Recent studies have suggested that insulin resistance exerts a strong influence on chronic hepatitis C virus (HCV) infection. | 22613000 |
| Parkinson Disease | Deregulated Nutrient Sensing | Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease. | 22613205 |
| Neurodegenerative Disorders, Primary malignant neoplasm, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Disease | Deregulated Nutrient Sensing | SIRT1 gene has been connected to many cellular processes and implicated in human diseases, such as obesity, type 2 diabetes, cancer and neurodegenerative diseases. | 22613205 |
| palladium | Deregulated Nutrient Sensing | Studies in animal model have also associated SIRT1 with aggregation of alpha-synuclein, a critical protein in the PD pathogenesis. | 22613205 |
| palladium | Deregulated Nutrient Sensing | We hypothesized that the genetic variants within the regulatory regions of SIRT1 gene that repress its gene expression, rather than mutations in its coding region that abolish SIRT1 function, may contribute to PD as a risk factor. | 22613205 |
| palladium | Deregulated Nutrient Sensing | In this study, we genetically analyzed the promoter region of SIRT1 gene in sporadic PD patients and ethic-matched healthy controls. | 22613205 |
| palladium | Deregulated Nutrient Sensing | Three novel heterozygous sequence variants, g.69644133C>G, g.69644213G>A and g.69644351G>A, were identified in PD patients, but in none of controls, which may alter the transcriptional activities of SIRT1 gene promoter, resulting in reduced SIRT1 levels. | 22613205 |
| palladium | Deregulated Nutrient Sensing | Therefore, our results suggested that genetic variants within the SIRT1 gene promoter may repress SIRT1 gene expression, contributing to PD as a risk factor. | 22613205 |
| CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | 11.4% of the children had either TC or TG dyslipidemia, with 7.1% had only TC dyslipidemia, 4.9% had only TG dyslipidemia, and 0.6% of them had both TC and TG dyslipidemia. | 22613377 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence rates of TC dyslipidemia and TG dyslipidemia were different among age groups, but with no significant changes among age groups. | 22613377 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of TG dyslipidemia was significantly different, with obese children higher than those with normal or overweight children. | 22613377 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of TG dyslipidemia was higher in rural than urban areas. | 22613377 |
| Dyslipidemias, Atherosclerosis, Coronary heart disease | Deregulated Nutrient Sensing | Screening and intervention programs on dyslipidemia should be undertaken routinely in children, in order to prevent adult atherosclerosis and coronary heart disease. | 22613377 |
| Vascular Diseases, Acute myocardial infarction | Deregulated Nutrient Sensing | Relationship between endothelial nitric oxide synthase, insulin resistance and macrovascular disease in patients with acute myocardial infarction. | 22613431 |
| Vascular Diseases, Acute myocardial infarction | Deregulated Nutrient Sensing | To explore the relationship between endothelial nitric oxide synthase (eNOS) activity, insulin resistance and macrovascular disease in patients with acute myocardial infarction (AMI). | 22613431 |
| Vascular Diseases | Deregulated Nutrient Sensing | There is a close relationship between eNOS activity and the development of insulin resistance and macrovascular disease in AMI patients. | 22613431 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome related to insulin resistance. | 22616493 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The factors associated with impaired access blood flow were old age, diabetes mellitus and dyslipidemia. | 22619889 |
| HD Term Type, Dyslipidemias, physiopathological, Diabetes Mellitus | Deregulated Nutrient Sensing | This present study suggests that annual direct measurement of access blood flow as ultrasound dilution technique is an acceptable tool to screen AVF dysfunction, especially HD patients of old age, and/or with diabetes mellitus and dyslipidemia. | 22619889 |
| Dyslipidemias, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Study design, rationale, and baseline characteristics: evaluation of fenofibric acid on carotid intima-media thickness in patients with type IIb dyslipidemia with residual risk in addition to atorvastatin therapy (FIRST) trial. | 22622962 |
| Dyslipidemias | Deregulated Nutrient Sensing | These data suggest that the use of OCs may reduce the risk of dyslipidemia, mainly due to the decreased risk of low HDL-C, in Korean women. | 22625865 |
| vascular inflammations, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin and leptin are important markers of insulin resistance and vascular inflammation in metabolic and cardiovascular diseases. | 22633795 |
| Hashimoto Disease, Inflammation, Haiti | Deregulated Nutrient Sensing | The relationship between inflammation, Hashimoto's thyroiditis (HT) and insulin resistance is still controversial. | 22639339 |
| Haiti | Deregulated Nutrient Sensing | These results suggest that HT patients with high RBP4 and A-FABP levels might deserve a particular attention, being potentially more exposed to develop insulin resistance and increased cardiovascular risk. | 22639339 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | The mammalian target of rapamycin complex 1 (mTORC1) is aberrantly activated in many head and neck squamous cell carcinomas (HNSCCs). | 22644799 |
| Microalbuminuria, Hypertension, CTCAE, Retinal Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Obese patients more often had elevated HbA1c (>=7.5%), hypertension or dyslipidemia (irrespective of age), microalbuminuria (adults), or retinopathy (elderly) than nonobese patients. | 22645200 |
| Precocious pubarche | Deregulated Nutrient Sensing | IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance. | 22646060 |
| MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE, Precocious pubarche | Deregulated Nutrient Sensing | We have previously reported that severe pre- and post-natal growth restriction associated with insulin resistance and precocious pubarche in a woman without body asymmetry or other SRS features resulted from a balanced translocation affecting the regulation of her IGF2 gene expression. | 22646060 |
| MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE, Precocious pubarche | Deregulated Nutrient Sensing | We hypothesised that severe pre- and post-natal growth restriction associated with insulin resistance and precocious pubarche in the absence of SRS are also caused by downregulation of IGF2 through hypomethylation, gene mutation or structural chromosomal abnormalities. | 22646060 |
| MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE, Precocious pubarche | Deregulated Nutrient Sensing | Our case of growth restriction, premature pubarche and insulin resistance in the absence of body asymmetry or other features of SRS adds to the expanding phenotype of IGF2/H19 methylation abnormalities. | 22646060 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | There were differences among Italian macro-areas mainly for obesity, hypertension, dyslipidaemia and diabetes. | 22647342 |
| Cachexia, Generalized amyotrophy | Deregulated Nutrient Sensing | Insulin resistance of protein anabolism has been speculated to underlie the skeletal muscle wasting characteristic of cancer cachexia. | 22647419 |
| Increased insulin level, Carcinoma of lung | Deregulated Nutrient Sensing | We tested whether insulin resistance is present in cachectic lung cancer patients and if a sustained, physiological elevation of amino acids with hyperinsulinemia would compensate for it. | 22647419 |
| Non-Small Cell Lung Carcinoma, Cachexia | Deregulated Nutrient Sensing | NSCLC patients with moderate cachexia showed considerable insulin resistance of glucose and of whole-body protein anabolism. | 22647419 |
| Malignant neoplasm of gastrointestinal tract, Diabetes Mellitus | Deregulated Nutrient Sensing | For patients with gastrointestinal cancer complicated with diabetes mellitus, microbiota enteral nutrition can reduce insulin resistance, improve the immune status, and promote postoperative recovery. | 22648843 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | When compared with non-tobacco and ex-tobacco users, overall current tobacco users were younger, more likely to be male subjects and less likely to have diabetes mellitus, hypertension and dyslipidaemia. | 22652700 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Alanine aminotransferase (ALT) and g-glutamyltransferase (GGT) are associated with insulin resistance and arteriosclerotic disease. | 22653114 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | Adipokines, ghrelin and obesity-associated insulin resistance in nondiabetic patients with acute coronary syndrome. | 22653312 |
| Obesity, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | In conclusion, in ACS patients, obesity and obesity-related changes in plasma leptin and adiponectin are associated with and likely contribute to negatively modulate insulin resistance. | 22653312 |
| Cessation of life, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The risk factors underlying the cause of death are associated with hypertension, obesity and dyslipidemia. | 22655455 |
| Dyslipidemias, Chest Pain | Deregulated Nutrient Sensing | Myocardial bridging assessed by multidetector computed tomography: likely cause of chest pain in younger patients with low prevalence of dyslipidemia. | 22658689 |
| Lipemia - observation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | o-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity. | 22661243 |
| Triple-Negative Breast Cancer Finding, Neoplasm Metastasis, Breast Carcinoma | Deregulated Nutrient Sensing | Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer. | 22661383 |
| Triple-Negative Breast Cancer Finding | Deregulated Nutrient Sensing | The definite role of SIRT1 is not clear now, and few studies have documented the value of SIRT1 in triple-negative breast cancer (TNBC). | 22661383 |
| Breast Carcinoma | Deregulated Nutrient Sensing | SIRT1+ group was associated with shorter DFS and OS compared with SIRT1- group in TNBC, non-TNBC, and overall breast cancer patients, according to univariate Cox regression analysis. | 22661383 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Our study provides evidence that expression of SIRT is associated with worse prognosis in TNBC and non-TNBC and SIRT1 could be a potential therapeutic target in breast cancer. | 22661383 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Patterns and determinants of dyslipidaemia in 'Young' versus 'Not so Young' patients of coronary artery disease: a multicentric, randomised observational study in northern India. | 22664802 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG. | 22664802 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG. | 22664802 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Almost 83% of doctors were aware that Indians have a genetic predisposition to diabetes due to an inherently smaller beta cell mass associated with insulin resistance. | 22666947 |
| Non-alcoholic Fatty Liver Disease, ETV3 wt Allele | Deregulated Nutrient Sensing | The MetS is associated with NAFLD, with the WHO definition being the best to determine its presence, probably because of the inclusion of insulin resistance as a main component. | 22668875 |
| Osage language, Seizures, Hyperglycemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Individuals with SZ also had significantly more severe atherogenic profiles (obesity, dyslipidemia, hyperglycemia) than OSA patients (P <= .05). | 22669072 |
| Dyslipidemias, Chronic disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity is closely associated with chronic diseases such as hypertension, type 2 diabetes mellitus (T2DM), and dyslipidemia. | 22672914 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | BMI was strongly associated with hypertension, while WC was strongly associated with T2DM and dyslipidemia. | 22672914 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | However, whether adipokines play a role in the development of insulin resistance (IR) in non-obese ESRD patients is unknown. | 22673293 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim was to investigate new markers for type 2 diabetes (T2DM) dyslipidemia related with LDL and HDL metabolism. | 22676273 |
| Non-alcoholic Fatty Liver Disease, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance (IR) is the major driving force behind development and progression of atherosclerosis in patients with nonalcoholic fatty liver disease (NAFLD). | 22676459 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Modifiable cardiovascular risk factors also hypertension were dominated by dyslipidemia (29.8%) and diabetes (24.6%). | 22677180 |
| Atherosclerosis | Deregulated Nutrient Sensing | Chronic HCV infection was associated with severe insulin resistance and mild atherosclerosis: a population-based study in an HCV hyperendemic area. | 22678465 |
| Hepatitis C, Atherosclerosis | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) affects glucose and lipid metabolism in vitro; however, it is unclear whether HCV infection is associated with insulin resistance and atherosclerosis at the population level. | 22678465 |
| Hepatitis C, Atherosclerosis | Deregulated Nutrient Sensing | This population-based study in an HCV hyperendemic area revealed that chronic HCV infection was associated with severe insulin resistance and with mild atherosclerosis, suggesting a unique characteristic of HCV-related metabolic abnormality. | 22678465 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Pitavastatin shows greater lipid-lowering efficacy over 12 weeks than pravastatin in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia. | 22679249 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | Path analysis revealed that age, sex, perceived social support, history of angina, and dyslipidaemia had both direct effect and indirect effect through psychological distress on the physical health component of HRQoL. | 22679250 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Additionally, our study suggested that UA level be an independent risk factor to obesity, hypertension and dyslipidemia, but a protective factor to hyperglycemia. | 22682157 |
| Metabolic Diseases | Deregulated Nutrient Sensing | In line with this premise, decreased activity of PARP-1 or CD38-both NAD(+) consumers-increases NAD(+) bioavailability, resulting in SIRT1 activation and protection against metabolic disease. | 22682224 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | We show that NR supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities. | 22682224 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis, Thigh structure | Deregulated Nutrient Sensing | The association of insulin resistance and carotid atherosclerosis with thigh and calf circumference in patients with type 2 diabetes. | 22682537 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | The relationship between body composition parameters such as thigh and calf circumference and insulin resistance or atherosclerosis in type 2 diabetes is poorly understood. | 22682537 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Thigh and calf circumference were correlated with insulin resistance and carotid atherosclerosis, and thigh circumference was independently associated with insulin resistance and carotid atherosclerosis in patients with type 2 diabetes. | 22682537 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Metformin is a drug to improve glycemic control by reducing insulin resistance and is currently considered to be one of the first-choice drugs for type 2 diabetes mellitus (T2DM). | 22687486 |
| Negative Regulation of Cell Cycle, NCI CTEP SDC Retinoblastoma Sub-Category Terminology, Necrosis | Deregulated Nutrient Sensing | All these changes were followed by increase in ATP-sensing enzyme AMP-activated protein kinase (AMPK) and declines in cyclin E2 as well as phosphorylated retinoblastoma, resulting in cell-cycle arrest, senescence, and necrosis. | 22689530 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes was rare but dyslipidemia and family history were frequent in group II. | 22690091 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects. | 22690097 |
| Rheumatoid Arthritis, Necrosis | Deregulated Nutrient Sensing | Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance. | 22691241 |
| Refractory anemias, Tumor necrosis | Deregulated Nutrient Sensing | Tumor necrosis factor (TNF), a pro-inflammatory cytokine with a major pathogenetic role in RA, may promote insulin resistance by inducing Ser312 phosphorylation (p-Ser312) of insulin receptor substrate (IRS)-1 and downregulating phosphorylated (p-)AKT. | 22691241 |
| Refractory anemias | Deregulated Nutrient Sensing | Western blot analysis in seven active RA patients with high insulin resistance showed reduction in p-Ser312 IRS-1 (P = 0.043) and increase in p-AKT (P = 0.001) over the study period. | 22691241 |
| Refractory anemias, Disease remission | Deregulated Nutrient Sensing | Anti-TNF therapy improved insulin sensitivity and reversed defects in the insulin signaling cascade in RA patients with active disease and high insulin resistance. | 22691241 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Our aim was to investigate the association of serum total testosterone levels with nonalcoholic fatty liver disease (NAFLD), adjusting for the influence of VAT and insulin resistance. | 22691278 |
| Dyslipidemias, Sedentary, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Conversely, frequencies of hypertension, dyslipidemia, diabetes, obesity, smoking, sedentarism, and hormonal contraception were similar in patients with or without aPL (p >= 0.253). | 22692396 |
| Dyslipidemias | Deregulated Nutrient Sensing | It has been suggested that a reduced HDL particle size could be another feature of the atherogenic dyslipidemia found among viscerally obese subjects. | 22695528 |
| Asthma, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was the most prevalent chronic condition (5.3%), followed by dyslipidemia (4.6%), asthma (0.9%), and diabetes (0.3%). | 22698173 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | Both SATV and TAT volume (TATV) correlated significantly with severity of liver disease as determined by NAS score whereas presence of MS or insulin resistance had no correlation with histological severity. | 22700629 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | The DM group had a higher mean age prevalence of history of hypertension, dyslipidemia, ischemic heart disease, high Killip class, and diagnoses as non-ST elevation MI than the non-DM group. | 22707890 |
| atherosclerotic, Coronary heart disease | Deregulated Nutrient Sensing | Insulin resistance predicts progression of de novo atherosclerotic plaques in patients with coronary heart disease: a one-year follow-up study. | 22709409 |
| Plaque, Atherosclerotic | Deregulated Nutrient Sensing | Insulin resistance has been generally recognized as a novel risk factor based on epidemiological studies; however, few researches have focused on its effect on coronary atherosclerotic plaque progression. | 22709409 |
| Plaque, Atherosclerotic, Coronary heart disease, diabetic | Deregulated Nutrient Sensing | Insulin resistance is an independent predictor of atherosclerosis plaque progression in patients with coronary heart disease in both the diabetic and non-diabetic population. | 22709409 |
| Dyslipidemias, Granuloma Annulare | Deregulated Nutrient Sensing | Dyslipidemia in granuloma annulare: a case-control study. | 22710282 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is more common in generalized than in localized/disseminated disease, and the annular lesion morphology is associated with hypercholesterolemia and DLP. | 22710282 |
| Obesity, Abdominal, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | The most prevalent cardiovascular risk factors were dyslipidemia (34.2%), abdominal obesity (19.7%) and overweight (18.0%). | 22715112 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Overweight and obese children were 4.4 times more likely to have dyslipidemia (P < 0.001). | 22715112 |
| Anxiety, CTCAE 3.0, Dyslipidemias, Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression. | 22717171 |
| Anxiety, CTCAE 3.0, Dyslipidemias, Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | Dyslipidemia and obesity have been observed in persons with severe anxiety or depression, and in tricyclic antidepressant (TCA) users. | 22717171 |
| Inflammation, Dyslipidemias, Depression, CTCAE, Obesity, Anxiety Disorders | Deregulated Nutrient Sensing | Increased dyslipidemia and (abdominal) obesity risk in patients with more severe anxiety disorders and depression may be partly explained by chronic low-grade inflammation and smoking. | 22717171 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Vitamin D deficiency is highly prevalent and is associated with dyslipidemia and cardiovascular disease. | 22718799 |
| Hyperglycemia | Deregulated Nutrient Sensing | Does insulin resistance drive the association between hyperglycemia and cardiovascular risk? | 22720085 |
| Communicable Diseases, Fibrosis Assessment, Hepatobiliary Disorder, Hepatitis C, Chronic, Failure (biologic function) | Deregulated Nutrient Sensing | The interaction between insulin resistance, liver fibrosis and early virological response in Egyptian patients with chronic hepatitis C. Hepatitis C virus (HCV) infection may induce insulin resistance (IR) irrespective of the severity of liver disease, and there is evidence of a central role for IR in failure to achieve sustained virological response (SVR) in HCV patients. | 22720272 |
| Inflammation, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Vascular Diseases | Deregulated Nutrient Sensing | NO-deficient states are characterized by cell senescence, oxidative stress, inflammation, endothelial dysfunction, vascular disease, insulin resistance and type 2 diabetes mellitus. | 22722323 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Hemoglobin A1c showed significant association with abdominal obesity and dyslipidemia and the clustering of cardiometabolic risk factors (odds ratios, 1.58-1.90; all P < 0.05). | 22722567 |
| Hyperlipidemia, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Both waist-to-stature ratio (WSR) (area under the curve 0.75, p=0.002) and waist circumference (WC) (area under the curve 0.77, p=0.001) but not waist-to-hip ratio (WHR) (area under the curve 0.62, p=0.143) were shown to be good markers of increased cardiovascular risk, insulin resistance and dislipidemia in PCOS patients. | 22727921 |
| Atherosclerotic lesion, Atherosclerosis | Deregulated Nutrient Sensing | Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. | 22728065 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Development of concomitant fasting glucose intolerance in knock-in mice highlights aberrant B cell selection as a potential risk factor for type 1 diabetes, and suggests altered BCR signalling as a mechanism to cause biased cellular and Ig repertoire selection, ultimately contributing to B cell-mediated autoimmune predisposition. | 22728826 |
| Dyslipidemias | Deregulated Nutrient Sensing | One of its principal risk factors is dyslipidemia. | 22728834 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our data show that dyslipidemia is generally undertreated in high-risk patients, despite the fact that hospitalization brings them in contact with specialized physicians. | 22728834 |
| Thyroid dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia in thyroid dysfunction has always been attributed to changes in thyroid hormone (TH) levels. | 22730515 |
| Lipemia - observation, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | In addition, elevated postprandial lipemia is an indicator of poor lipid clearance, and it has been associated with atherosclerosis, insulin resistance, and obesity. | 22738038 |
| Hypertensive (finding), Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Male sex, advanced age, higher serum triglycerides, and homeostasis model assessment of insulin resistance levels were all significantly associated with the increased risks of pre-diabetes or diabetes in new-onset hypertensive patients when analyzed by the logistic regression analysis. | 22738422 |
| Inflammation, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Rates of diabetes, dyslipidaemia, hypertension and inflammation are high and increased with age and were associated with urbanization. | 22738663 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | One fourth had hypertension; 32.1%, dyslipidemia; and 13%, diabetes mellitus. | 22740730 |
| airway disease, Sleep Disorders | Deregulated Nutrient Sensing | Abdominal adiposity and obstructive airway disease: testing insulin resistance and sleep disordered breathing mechanisms. | 22742416 |
| Symptoms, Sleep-Disordered Breathing | Deregulated Nutrient Sensing | This study examined associations of abdominal adiposity with lung function, asthma symptoms and current doctor-diagnosed asthma and mediation by insulin resistance (IR) and sleep disordered breathing (SDB). | 22742416 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The objective of the study was to evaluate the efficacy and site of action of an insoluble dietary fiber derived from maize (HAM-RS2) in improving insulin resistance in subjects at increased risk of type 2 diabetes mellitus. | 22745235 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | HAM-RS2 improved peripheral but not hepatic insulin resistance and requires further study as an intervention in patients with or at risk for type 2 diabetes. | 22745235 |
| Virus Diseases | Deregulated Nutrient Sensing | Cytokines are known to play an important role not only in the mechanisms of insulin resistance and glucose disposal defects but also in the pathological processes occurring in the liver during viral infection. | 22745767 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This study analyzed the relationships between Lp(a) and both diabetes and insulin resistance in an adult cohort from the island of Gran Canaria, Spain. | 22748161 |
| Increased insulin level, Angina Pectoris, Variant | Deregulated Nutrient Sensing | Effect of insulin resistance associated with compensatory hyperinsulinemia on the long-term prognosis in patients with vasospastic angina. | 22748286 |
| Increased insulin level, Angina Pectoris, Variant, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance associated with compensatory hyperinsulinemia plays a significant role in the pathogenesis of cardiovascular diseases, including vasospastic angina (VSA). | 22748286 |
| Increased insulin level | Deregulated Nutrient Sensing | However, the effects of insulin resistance associated with hyperinsulinemia on the long-term prognosis in patients with VSA remain unclear. | 22748286 |
| Increased insulin level | Deregulated Nutrient Sensing | These data indicate that insulin resistance associated with compensatory hyperinsulinemia increases the risk of cardiac events in VSA patients. | 22748286 |
| Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjusting for age and sex, hypertension, dyslipidemia, and atrial fibrillation were more frequent, and diabetes mellitus was less frequent, among Miami Hispanics compared to Mexicans. | 22749627 |
| Primary malignant neoplasm, Breast Carcinoma | Deregulated Nutrient Sensing | Based on our results, the downregulation of SIRT1/2 expression may play an important role in the regulation of breast cancer cell death; thus, SIRT1/2 may be a novel molecular target for cancer therapy and these findings may provide a molecular basis for targeting SIRT1/2 in future cancer therapy. | 22751989 |
| Cardiac dysfunction, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes and insulin resistance are often associated with the co-occurrence of coronary atherosclerosis and cardiac dysfunction. | 22752026 |
| Ventricular Dysfunction, Ischemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This suggests that insulin resistance, rather than diagnosis of ischaemia or left ventricular dysfunction, affects the metabolism and perfusion features of patients with type 2 diabetes. | 22752026 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Previous studies have shown a positive relationship between insulin resistance and several common adult cancers. | 22752254 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance or dysglycaemia was defined using WHO criteria as the presence of diabetes mellitus, impaired fasting glycaemia (IFG) or impaired glucose tolerance (IGT). | 22752819 |
| Dyslipidemias, Aortic Valve Stenosis, Musculoskeletal Pain | Deregulated Nutrient Sensing | He was initially managed as a case of severe valvular aortic stenosis of rheumatic origin with associated dyslipidaemia and was referred for further evaluation and management abroad. | 22752829 |
| Atherosclerosis | Deregulated Nutrient Sensing | CDK5-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis. | 22753194 |
| Atherosclerosis | Deregulated Nutrient Sensing | Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. | 22753194 |
| Hypertensive disease, Hyperglycemia, Dyslipidemias, Liver Dysfunction | Deregulated Nutrient Sensing | In men, HBP (12.9 %), liver dysfunction (33.9 %), dyslipidemia (29.9 %), and hyperglycemia (2.7 %) were observed in the normal BMI group (18.5 < BMI <= 25 kg/m(2)). | 22760262 |
| Dyslipidemias, Liver Dysfunction, Obesity | Deregulated Nutrient Sensing | Asymptomatic abnormalities, particularly liver dysfunction and dyslipidemia, were observed in a substantial percentage of subjects without obesity. | 22760262 |
| Dyslipidemias, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Baseline clinical characteristics were similar except for higher dyslipidemia, systemic hypertension, and family history of coronary artery disease in the EES group. | 22762711 |
| Inflammation | Deregulated Nutrient Sensing | To investigate the role of low-grade inflammation and insulin resistance (HOMA2-IR) in adiposity-related increases in serum complement factor 3 (C3). | 22762725 |
| Inflammation | Deregulated Nutrient Sensing | Systemic low-grade inflammation and insulin resistance may represent two independent pathways by which body fat leads to elevated C3 levels. | 22762725 |
| Nausea and vomiting | Deregulated Nutrient Sensing | The preparation of patients with oral glucose solutions decreases the incidence of postoperative (thyroidectomy) insulin-resistance, and occurrence of nausea/vomiting during the postoperative period. | 22763301 |
| Refractory anemias, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidaemia were significantly more frequent in both DM groups than RA groups. | 22764043 |
| Dyslipidemias, Cardiovascular Diseases, Myocardial Ischemia, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidaemia is a major risk factor of cardiovascular diseases, the role of serum total cholesterol (Chol) especially LDL-Chol is well established in the pathogenesis of atherosclerosis and ischemic heart disease. | 22764575 |
| Refractory anemias, Rheumatoid Arthritis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR), a risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis (RA). | 22765047 |
| Endothelial dysfunction, Spondylitis | Deregulated Nutrient Sensing | Since insulin resistance can promote endothelial dysfunction, and anti-TNF-a treatment improves endothelial function in ankylosing spondylitis (AS) patients, in the present study we sought to assess whether an infusion of the anti-TNF-a monoclonal antibody-infliximab may improve insulin sensitivity in non-diabetic AS patients. | 22765845 |
| Obesity, Visceral | Deregulated Nutrient Sensing | ADRB3 Trp64Arg polymorphism, a missense mutation in the first transmembrane domain of the R3-adrenergic receptor is associated with visceral obesity and insulin resistance in the Pima Indian, French, and Finnish populations. | 22774474 |
| flavin-hypoxanthine dinucleotide | Deregulated Nutrient Sensing | We investigated the insulin resistance and adiponectin levels of children and adolescents with a family history of T2DM (FHD). | 22776852 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | IS patients showed a higher prevalence of dyslipidemia and hypertension and underwent MRI more frequently in 2004. | 22777532 |
| Congestive heart failure, Dyslipidemias, Atrial Fibrillation by ECG Finding, Diabetes Mellitus | Deregulated Nutrient Sensing | Atrial fibrillation, congestive heart disease and prior disability were significantly more common, while diabetes, current smoking and dyslipidemia were less frequent in the very elderly. | 22777655 |
| Dyslipidemias, Smoking, Diabetes Mellitus | Deregulated Nutrient Sensing | Smoking, elevated blood pressure, dyslipidaemia, and a family history of diabetes were not associated with this perception. | 22781026 |
| Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Chronic heart failure, Malignant Neoplasms, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most frequent comorbidities were: hypertension (60.0%), ischemic heart disease (16.0%), malignant tumor (10.9%), diabetes mellitus (10.5%), chronic heart failure (9.9%) and dyslipidemia (9.9%). | 22781564 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Individuals with obesity and abdominal adiposity are at higher risk for hypeinsulinaemia, insulin resistance, and diabetes. | 22783566 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Reduction of insulin resistance and plasma glucose level by salsalate treatment in persons with prediabetes. | 22784842 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | To evaluate the effect of salsalate as an antiinflammatory agent on insulin resistance and glycemic control in persons with prediabetes. | 22784842 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Treatment with salsalate can reduce insulin resistance and the FPG level in subjects with prediabetes. | 22784842 |
| Dyslipidemias, Congestive heart failure | Deregulated Nutrient Sensing | Statin therapy attenuates the production of monocyte pro-inflammatory cytokines, and ameliorates the cardiac function and may improve long-term prognosis in CHF patients with dyslipidemia. | 22785006 |
| Increased insulin level, Hepatobiliary Disorder, Liver carcinoma, Hepatocarcinogenesis | Deregulated Nutrient Sensing | Hyperinsulinemia and/or insulin resistance in liver disease is associated with hepatocarcinogenesis, growth of hepatocellular carcinoma, and poor prognosis. | 22790351 |
| Diabetes Mellitus, Glucose Intolerance (disease), Saint Lucia, Diabetes Mellitus, Non-Insulin-Dependent, Liver Cirrhosis | Deregulated Nutrient Sensing | Glucose intolerance in patients with liver cirrhosis (LC), known as hepatogenous diabetes, is thought to be distinct from type 2 diabetes (T2DM) in some aspects. | 22790351 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Even among subjects with NGT, there is a significant increase in CIMT with increasing levels of HbA1c, showing the value of using HbA1c for diagnosis of glucose intolerance. | 22795336 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance is associated with low T3/T4 ratio in pre diabetic euthyroid Pakistani subjects. | 22795338 |
| Increased insulin level | Deregulated Nutrient Sensing | Marked hyperinsulinemia and insulin resistance were observed in IGT subjects. | 22795338 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are associated with low T3/T4 ratio in pre-diabetic euthyroid Pakistani subjects. | 22795338 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Future prospective studies are needed to further explore these associations to determine whether phthalate exposure can alter glucose metabolism and increase the risk of insulin resistance and diabetes. | 22796563 |
| Amyotrophic Lateral Sclerosis, Neurodegenerative Disorders | Deregulated Nutrient Sensing | Sirtuins (SIRT1-7; class III histone deactylases) modulate fundamental mechanisms in age-related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). | 22796962 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | When specifically analyzing mRNA and protein expression in the gray matter (cortical layers I-VI of the precentral gyrus, ventral/dorsal horn of the spinal cord) by in situ hybridization histochemistry and immunohistochemistry, we found increased levels of SIRT1, SIRT2 and SIRT5 in ALS which were significant for SIRT1 and SIRT5 mRNA in the spinal cord. | 22796962 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Novel therapeutic approaches in ALS could therefore target SIRT1 activation or SIRT2 inhibition. | 22796962 |
| Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance, and skeletal muscle nitric oxide synthase. | 22797309 |
| diabetic | Deregulated Nutrient Sensing | Increased ferritin concentrations correlate with insulin resistance in female type 2 diabetic patients. | 22797673 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Iron overload, which produces elevated levels of ferritin, may augment insulin resistance in female but not in male type 2 diabetes. | 22797673 |
| Metabolic Syndrome X, Cerebral Atherosclerosis | Deregulated Nutrient Sensing | Moreover, metabolic syndrome and insulin resistance were independent risk factors of moderate to severe ICAD but were not risk factors of moderate to severe extracranial atherosclerotic disease. | 22798326 |
| Rheumatoid Arthritis, Dyslipidemias, Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | In conclusion, vitamin D deficiency was associated with the metabolic syndrome and dyslipidemia in rheumatoid arthritis, suggesting a potential role in cardiovascular disease risk. | 22800875 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia has been associated with hepatic fat deposition and ensuing insulin resistance. | 22801247 |
| Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Mitochondrial dysfunction is apparent only in inactive longstanding T2DM patients, which suggests that mitochondrial function and insulin resistance do not depend on each other. | 22802091 |
| diabetic, Coronary Artery Disease, Edema, Heart failure | Deregulated Nutrient Sensing | Pioglitazone ameliorates insulin resistance, but has an adverse effect of oedema that may result in subsequent heart failure, especially in diabetic patients with coronary artery disease. | 22802358 |
| Kidney Failure, Chronic, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Chronic kidney failure is associated with dyslipidemia and accelerated atherosclerosis. | 22811228 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The discovery of new adipokine, visfatin can significantly enhance our knowledge of insulin resistance and diabetes mellitus. | 22813406 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We explored the relation of visfatin concentrations to cardiovascular risk factors, adiponectin and insulin resistance criteria in patients with type 2 diabetes mellitus (T2DM). | 22813406 |
| diabetic | Deregulated Nutrient Sensing | In conclusion high circulating levels of visfatin could be in healthy relations with cardiovascular risk factors, insulin resistance status and adiponectin in diabetic patients. | 22813406 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Insulin resistance and obesity are associated in a proportion of Indian patients with NAFLD. | 22813407 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Reports of urban based studies suggest an increase in the prevalence of MS worldwide along with diabetes, hypertension and atherogenic dyslipidemia. | 22813408 |
| Tuberculosis, Pulmonary | Deregulated Nutrient Sensing | Studies have proven correlation between low vitamin D levels and pulmonary tuberculosis (PTB) and low vitamin D levels and insulin resistance. | 22813409 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and alanine amino transaminase (ALT) levels in first degree relatives of type 2 diabetes mellitus. | 22813567 |
| Atherosclerosis, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Disease | Deregulated Nutrient Sensing | Insulin resistance is established as an independent predictor of a range of disorders such as obesity, hypertension, dyslipidemia, type 2 diabetes mellitus and atherosclerotic cardiovascular diseases. | 22813567 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | In nonalcoholic fatty liver disease, there is an elevation of ALT, raising the possibility that the prospective relationship between ALT and type 2 diabetes may reflect cross-sectional associations with insulin resistance or obesity. | 22813567 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To find the significance of insulin resistance and alanine aminotransferase level in first degree relatives of type 2 diabetes mellitus. | 22813567 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Results of the study conclude that there is a high prevalence of insulin resistance in the first degree relatives of type 2 diabetes mellitus. | 22813567 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | ALT levels in the first degree relatives of type 2 diabetes mellitus had increased levels of insulin resistance, the pathogenesis suggesting increase in ALT levels as seen in insulin resistance condition. | 22813567 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama study. | 22814404 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Although several surrogate measures of insulin resistance have been proposed, their associations with cardiovascular disease (CVD) have not been evaluated sufficiently. | 22814404 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Our findings suggest that insulin resistance significantly increases the risk of incident CVD through metabolic syndrome in Japanese. | 22814404 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity (AO) is a risk factor of insulin resistance and its metabolic consequences. | 22814438 |
| Obesity | Deregulated Nutrient Sensing | Oxidative stress is associated with C-reactive protein in nondiabetic postmenopausal women, independent of obesity and insulin resistance. | 22816656 |
| Obesity | Deregulated Nutrient Sensing | We tested the hypothesis that elevated levels of oxidative stress markers are associated with increased C-reactive protein (CRP) and that this is independent of obesity and insulin resistance. | 22816656 |
| Obesity | Deregulated Nutrient Sensing | This finding was independent of obesity and insulin resistance in nondiabetic postmenopausal women. | 22816656 |
| Inflammation, Malnutrition, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. | 22817124 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In the Cox proportional hazards model, the risk of diabetes mellitus increased with increasing BMI, even after adjusting for age, sex, blood pressure, metabolic profiles, and insulin resistance. | 22821094 |
| diabetic | Deregulated Nutrient Sensing | Telmisartan at 80 mg/day increases high-molecular-weight adiponectin levels and improves insulin resistance in diabetic patients. | 22821644 |
| Hypertension, CTCAE, diabetic | Deregulated Nutrient Sensing | In diabetic patients with hypertension, high-dose telmisartan increased HMW adiponectin levels and improved insulin resistance through activation of PPAR-gamma. | 22821644 |
| Pre-Gestational Diabetes | Deregulated Nutrient Sensing | Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy. | 22825259 |
| diabetic | Deregulated Nutrient Sensing | Pregnancy exacerbates insulin resistance in diabetic patients, and these patients may require high doses of insulin. | 22825259 |
| Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Traditional risk factor for cardiovascular disease such as hyperglycemia, hypertension, smoking, obesity, and dyslipidemia were assessed. | 22826078 |
| vascular inflammations | Deregulated Nutrient Sensing | However, it remains unknown whether fasting serum levels of apoB48 are independently correlated with insulin resistance and vascular inflammation in humans. | 22827961 |
| Dyslipidemias | Deregulated Nutrient Sensing | Cigarette smoking had been confirmed as an increased risk for dyslipidemia, but none of the evidence was from long-lived population. | 22828289 |
| Dyslipidemias | Deregulated Nutrient Sensing | In summary, we found that among Chinese nonagenarians/centenarians, cigarette smoking habits were not associated with increased risk for dyslipidemia, which was different from the association of smoking habits with dyslipidemia in general population. | 22828289 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Major liver resection results in early exacerbation of insulin resistance, and may be a risk factor of developing overt diabetes in the future. | 22829443 |
| Hyperlipidemia, Steatohepatitis | Deregulated Nutrient Sensing | Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. | 22829450 |
| Hyperlipidemia, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Aging is closely associated with muscle insulin resistance, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. | 22829450 |
| Hyperlipidemia | Deregulated Nutrient Sensing | We examined the hypothesis that muscle insulin resistance in healthy aging promotes increased hepatic de novo lipogenesis (DNL) and hyperlipidemia by altering the distribution pattern of postprandial energy storage. | 22829450 |
| Hyperlipidemia, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These results strongly support the hypothesis that muscle insulin resistance in aging promotes hyperlipidemia and NAFLD by altering the pattern of postprandial carbohydrate storage away from muscle glycogen and into hepatic DNL. | 22829450 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In addition, hypertension and dyslipidaemia were the most common risk factors (58% and 40%). | 22829507 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dietary and/or physical activity induced changes in CRP may be largely independent of traditional CVD risk factors in persons with dyslipidemia. | 22831953 |
| Atherosclerosis | Deregulated Nutrient Sensing | Fish consumption, insulin sensitivity and beta-cell function in the Insulin Resistance Atherosclerosis Study (IRAS). | 22835984 |
| Atherosclerosis | Deregulated Nutrient Sensing | We examined the cross-sectional association between fish consumption and measures of insulin sensitivity and secretion in 951 non-diabetic participants in the Insulin Resistance Atherosclerosis Study (IRAS). | 22835984 |
| Alzheimers Disease | Deregulated Nutrient Sensing | SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's Disease. | 22836009 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | We assessed the prevalence of high LDL-C, low HDL-C, high TG, high non-HDL-C, and mixed dyslipidemia by using National Health and Nutrition Examination Survey (NHANES) data to estimate the proportions of U.S. adults not at guideline-recommended lipid goals. | 22836069 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Also, 21% (42.0M) of U.S. adults have mixed dyslipidemia (high LDL-C with either low HDL-C and/or high TG), with nearly 6% (11.6M) having all three lipid abnormalities. | 22836069 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia in the United States continues to be high, with the majority of U.S. adults now affected by some form of lipid abnormality. | 22836069 |
| indicine-N-oxide, Dyslipidemias | Deregulated Nutrient Sensing | Diet and dyslipidemias in a Lithuanian rural population aged 25-64: the CINDI survey. | 22836294 |
| Atherosclerosis | Deregulated Nutrient Sensing | Levels of four urinary F(2)-isoprostanes (F(2)-IsoPs) were examined in a large sample of the Insulin Resistance Atherosclerosis Study (IRAS) multiethnic cohort: 237 African Americans (AAs), 342 non-Hispanic whites (NHWs), and 275 Hispanic whites (HWs). | 22836686 |
| Steatohepatitis, Prostate Cancer Outcomes Study, Obesity, Hyperandrogenism, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance. | 22837189 |
| Prostate Cancer Outcomes Study, Non-alcoholic Fatty Liver Disease, Polycystic Ovary Syndrome, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease may be evident in women with polycystic ovary syndrome (PCOS), both conditions being associated with obesity and insulin resistance. | 22837189 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | These data suggest that HA-PCOS is associated with hepatic steatosis, independent of obesity and insulin resistance. | 22837189 |
| Chief complaint (finding), Diabetes Mellitus | Deregulated Nutrient Sensing | Subjective sleep complaints are associated with insulin resistance in individuals without diabetes: the PPP-Botnia Study. | 22837368 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The evidence with respect to insulin resistance (IR) and insulin secretion in individuals without type 2 diabetes has been scarce and elusive. | 22837368 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Crude mortality was highest in patients with MI with diabetes (11.9%) and hypertension (9.8%) and lowest in those with smoking histories (5.4%) and dyslipidemia (4.6%). | 22840346 |
| Fibrinolysis, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypofibrinolysis displayed by elevated serum plasminogen activator inhibitor 1 (PAI-1) level has been associated with cardiovascular disease (CVD) and its risk factors such as obesity and insulin resistance. | 22840426 |
| Hyperandrogenemia | Deregulated Nutrient Sensing | Severe hyperandrogenemia and insulin resistance in a 12-year-old girl. | 22840945 |
| Neoplasms | Deregulated Nutrient Sensing | This is the first phase I, dose-finding study of AZD8055, a first-in-class dual mTORC1/2 inhibitor, in Japanese patients with advanced solid tumors. | 22843211 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease. | 22843503 |
| acetate-CoA ligase activity | Deregulated Nutrient Sensing | CACS, lipids, lipoproteins, inflammatory markers, insulin resistance and PON1 activity, concentration and Q192R and L55M genotypes were measured. | 22846213 |
| Dyslipidemias, Amyloidosis | Deregulated Nutrient Sensing | Revisiting secondary amyloidosis for an inadequately investigated feature: dyslipidemia. | 22847292 |
| Dyslipidemias, Reactive systemic amyloidosis | Deregulated Nutrient Sensing | Data on frequency and nature of dyslipidemia in patients with secondary amyloidosis are not conclusive. | 22847292 |
| Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia was closely associated with GFR in a manner that patients with advanced stage kidney disease had lower serum lipid levels. | 22847292 |
| Cholelithiasis, Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GD) are both highly prevalent in the general population and associated with obesity and insulin resistance. | 22848440 |
| Steatohepatitis, Non-alcoholic Fatty Liver Disease, Dyslipidemias, Liver Cirrhosis | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease is associated with insulin resistance and dyslipidaemia and can progress to steatohepatitis and cirrhosis. | 22849970 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Low-dose rosuvastatin improves the functional and morphological markers of atherosclerosis in asymptomatic postmenopausal women with dyslipidemia. | 22850442 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Several large-scale studies have shed light on the primary preventive efficacy of statins against atherosclerotic diseases in the course of treatment of dyslipidemia. | 22850442 |
| Dyslipidemias, Coronary Artery Disease, Stiff toe | Deregulated Nutrient Sensing | The potent statin improves baPWV and carotid stiffness b, in addition to CIMT (surrogate markers of coronary artery disease), in postmenopausal women with low-risk dyslipidemia. | 22850442 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | PPARg immunostaining level was significantly lower in diabetics, hypertensive and insulin resistance patients (P<0.05). | 22853971 |
| Inflammation, Colorectal Neoplasms | Deregulated Nutrient Sensing | Dietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation. | 22854408 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The effect of insulin resistance on postprandial triglycerides in Korean type 2 diabetic patients. | 22854916 |
| Diabetes Mellitus, Insulin-Dependent, Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk for cardiovascular disease in this population and progression of nephropathy. | 22856231 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, measured with eGDR, predicts the increment in UAE in subjects with type 1 diabetes. | 22856231 |
| Microalbuminuria, diabetic | Deregulated Nutrient Sensing | Since progression to microalbuminuria is likely to occur in majority of diabetic patients, there is a need to further explore the role of risk factors such as insulin resistance. | 22856231 |
| Dyslipidemias, Restenosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Female sex (1*79, 1*25-2*56), diabetes (2*31, 1*61-3*31), and dyslipidaemia (2*07, 1*01-4*26) were independent predictors of restenosis or occlusion after the two procedures. | 22857850 |
| Vertigo, Atrial Fibrillation by ECG Finding, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Middle aged male, diabetes, hypertension, dyslipidemia, coronary artery disease, and atrial fibrillation are risk factors for subsequent stroke in vertigo patients. | 22858717 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | Young adults had lower levels of high-density lipoprotein cholesterol, less glucose intolerance, and less hypertension. | 22863157 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The liver-derived Fetuin-A (a2-Heremans Schmid glycoprotein) is a circulating glycoprotein that may be related to insulin resistance and polycystic ovary syndrome (PCOS). | 22865037 |
| Sarcopenia | Deregulated Nutrient Sensing | However, the gender effects on muscle strength, lean tissue in the arms, homeostatic assessment of insulin resistance, and body weight detected in this study suggest that additional research is needed on elderly male subjects with sarcopenia. | 22866000 |
| Lipodystrophy, Disturbance | Deregulated Nutrient Sensing | Lipodystrophy defined by Fat Mass Ratio in HIV-infected patients is associated with a high prevalence of glucose disturbances and insulin resistance. | 22866963 |
| Lipodystrophy, Disturbance | Deregulated Nutrient Sensing | FMR lipodystrophy definition seems to be a more sensitive determinant of insulin resistance and glucose disturbances than clinical definition. | 22866963 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | In vivo sitagliptin treatment elevated GLP-1 and GLP-1 receptor expressions, increased cAMP level, and subsequently activated protein kinase A, liver kinase B1, AMP-activated protein kinase-a and endothelial NO synthase in spontaneously hypertensive rat renal arteries. | 22868389 |
| Hyperglycemia | Deregulated Nutrient Sensing | Identification of possible predictors (demographic, clinical, or genetic) for insulin resistance and glycaemic control during severe/acute hyperglycaemia. | 22869200 |
| Hyperglycemia | Deregulated Nutrient Sensing | The use of loop diuretics (P < 0.05) and antibiotics (P < 0.05) may indirectly predict worsening of insulin resistance or glycaemic control in patients with severe/acute hyperglycaemia. | 22869200 |
| Hyperglycemia | Deregulated Nutrient Sensing | Clinical and genetic factors contribute to worsening of insulin resistance and glycaemic control during severe/acute hyperglycaemia in patients with T2DM. | 22869200 |
| Hyperglycemia | Deregulated Nutrient Sensing | Early identification of factors that may influence insulin resistance and glycaemic control may help to achieve optimal glycaemic control during severe/acute hyperglycaemia. | 22869200 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Most studies pay attention to the relationship between insulin resistance and coronary artery disease (CAD) in patients with abnormal glucose tolerance. | 22871300 |
| Obesity | Deregulated Nutrient Sensing | Whether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known. | 22872690 |
| Obesity | Deregulated Nutrient Sensing | Although males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex. | 22872690 |
| Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | At baseline, data were collected on diabetes and major risk factors for mortality: social network, diet, physical activity and other lifestyle factors, obesity, hypertension, dyslipidemia, and previous cardiovascular disease and cancer. | 22875228 |
| ARCN1 gene, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Underweight might be more prevalent but coronary heart disease and dyslipidemia are less prevalent in Koreans with than without COPD in population setting. | 22876057 |
| deficiency aspects | Deregulated Nutrient Sensing | The balance between insulin deficiency and insulin resistance is variable at different phases of the condition. | 22876561 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia is present in people with diabetes as well as subjects with normal glucose tolerance (NGT). | 22876749 |
| Dyslipidemias, physiopathological | Deregulated Nutrient Sensing | Dyslipidemia is associated with dysfunction of pancreatic b cells in subjects with NGT and this is particularly evident in people with elevated TC and LDL-C levels, especially males. | 22876749 |
| Choline Dehydrogenase, Mitochondrial, Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | In patients without known CHD, cardiovascular risk factors were abundant (52.1% had hypertension, 43.6% had dyslipidemia, 41.4% had a family history of CHD, 58.5% were current or former smokers, and 14.9% were diabetic). | 22877813 |
| physiopathological, Diabetes Mellitus | Deregulated Nutrient Sensing | Using multivariate logistic regression analysis, low high-density lipoprotein cholesterol (HDL-C, P < .036), newly diagnosed non-insulin-dependent diabetes or insulin-resistance (NIDD/IR, P < .019) and the use of diuretics (P = .001) were independently associated with overt LV dysfunction. | 22879076 |
| Dyslipidemias | Deregulated Nutrient Sensing | The incidence of dyslipidemia increased with aging (P < 0.01). | 22883098 |
| TG gene, Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | After adjusted for age, sex, dyslipidemia and other risk factors, high TG group (TG>=2.26 mmol/L) appeared a significant independent predictor of newly identified carotid plaque (OR=1.37, 95%CI: 1.00-1.86). | 22883168 |
| Dyslipidemias, Dental Plaque | Deregulated Nutrient Sensing | After adjusting age, sex, dyslipidemia and other risk factors, serum fasting TG>=2.26 mmol/L appeared to be an independent predictor of newly developed carotid plaque. | 22883168 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Low blood HDL-C and hypertriglyceridemia are two major types of dyslipidemia in Chinese adults. | 22883727 |
| Inflammation, Obesity, Abdominal, Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | After adjustment for BMI, social-demographic, lifestyle and dietary factors and other TFAs, erythrocyte trans-18:1 was shown to be associated with a lower risk of type 2 diabetes (OR comparing extreme [first and fourth] quartiles 0.68, 95% CI 0.48, 0.97, p(trend) = 0.02), as well as 20-50% lower odds of central obesity, dyslipidaemia, hyperglycaemia, insulin resistance and chronic inflammation. | 22886370 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Higher trans-18:1 levels were associated with a lower risk of type 2 diabetes, whereas higher trans-18:2 levels were associated with dyslipidaemia. | 22886370 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It is indicated as a method of choice in accompanied atherogenic dyslipidemia and in patients, suffering diabetes mellitus type II. | 22888543 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance and exercise tolerance in heart failure patients: linkage to coronary flow reserve and peripheral vascular function. | 22889317 |
| Heart failure, Impaired exercise tolerance | Deregulated Nutrient Sensing | Insulin resistance has been linked to exercise intolerance in heart failure patients. | 22889317 |
| Heart failure, Impaired exercise tolerance | Deregulated Nutrient Sensing | The study confirms that insulin resistance is associated with exercise intolerance in heart failure patients and suggests that this is partly through reduced CFR. | 22889317 |
| Heart failure | Deregulated Nutrient Sensing | This is the first study to our knowledge that shows an association between CFR and exercise capacity in heart failure patients and links the relationship between insulin resistance and exercise capacity to CFR. | 22889317 |
| Neoplasms | Deregulated Nutrient Sensing | Lactate dehydrogenase (LDH) is an enzyme involved in anaerobic glycolysis and regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (mTOR)-containing complex 1 (PI3K/Akt/TORC1) pathway as well as tumor hypoxia/necrosis. | 22891270 |
| Refractory Cytopenia of Childhood | Deregulated Nutrient Sensing | We evaluated pretreatment and post-treatment serum LDH in 404 poor-risk patients with RCC treated with the TORC1 inhibitor temsirolimus or interferon alfa in an international phase III randomized trial. | 22891270 |
| Refractory Cytopenia of Childhood | Deregulated Nutrient Sensing | Serum LDH is a prognostic and a predictive biomarker for the survival benefit conferred by TORC1 inhibition in poor-risk RCC. | 22891270 |
| Refractory Cytopenia of Childhood, Neoplasms | Deregulated Nutrient Sensing | Further investigation of the predictive role of LDH as a measure of benefit with PI3K/TORC1 pathway inhibition in other RCC risk groups and other tumor types is warranted. | 22891270 |
| Impaired cognition | Deregulated Nutrient Sensing | Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. | 22892813 |
| Autoimmune Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was found in 69.4% of patients, 60% of FDR and 40.9% of controls (p < 0.0001 and p = 0.003 respectively), autoimmune diseases in 36.9% of patients, 30.4% of FDR and 13.4% of controls (p < 0.0001 and p = 0.011 respectively). | 22898439 |
| Autoimmune Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia and autoimmune diseases were significantly increased not only in patients as expected but also in their FDR. | 22898439 |
| Diabetes Mellitus, Non-Insulin-Dependent, Prostate carcinoma, Structure of posterior cerebral artery | Deregulated Nutrient Sensing | Androgen deprivation therapy (ADT) for prostate cancer (PCa) may increase peripheral insulin resistance, induce type 2 diabetes, change body composition, and alter lipoprotein profile. | 22898989 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, pediatric DALT occurred in non-obese adolescents with insulin resistance, distinct from diabetes types 1 or 2. | 22905982 |
| Microalbuminuria, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital. | 22906862 |
| Dyslipidemias, Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Accumulating evidence indicates that dyslipidaemia plays an important role in the progression of kidney disease in patients with diabetes. | 22906862 |
| Microalbuminuria, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Little information exists on the prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in China. | 22906862 |
| Microalbuminuria, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The aims of this study were to investigate the prevalence and control of dyslipidaemia among diabetic patients with microalbuminuria in a Chinese hospital as well as factors affecting the disease. | 22906862 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | Fewer patients with microalbuminuria were adherent to the therapy prescribed for dyslipidaemia (28.8% vs. 43.3%, p < 0.001). | 22906862 |
| Microalbuminuria, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | In China, diabetic patients with microalbuminuria displayed typical dyslipidaemias and were not adequately controlled. | 22906862 |
| Renal Cell Carcinoma | Deregulated Nutrient Sensing | Insulin resistance and risk of renal cell cancer: a case-control study. | 22908063 |
| Refractory Cytopenia of Childhood | Deregulated Nutrient Sensing | We aimed to explore whether insulin resistance (IR) plays an independent role in the development of RCC. | 22908063 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | We assessed insulin resistance according to insulin levels, alone or controlled for diabetes mellitus (DM). | 22908063 |
| Refractory Cytopenia of Childhood, Demographics Domain | Deregulated Nutrient Sensing | Insulin levels controlled or not controlled for DM, however, were inversely associated with the risk for RCC; notably, an approximately 40% higher risk was observed in the 1st tertile when compared with the 2nd and 3rd tertile levels of insulin resistance. | 22908063 |
| Refractory Cytopenia of Childhood, Demographics Domain, Obesity | Deregulated Nutrient Sensing | Our curdata suggest that insulin resistance may be inversely associated with RCC risk, independently of obesity, DM, lifestyle and hormonal confounding variables. | 22908063 |
| Obesity, Haiti | Deregulated Nutrient Sensing | Among the adipokines analyzed, the most notable finding was a 15% lower level of monocyte chemotactic protein-1 in HT users, particularly with respect to its suggested mediator role between obesity and insulin resistance. | 22914204 |
| Hyperglycemia, Critical Illness | Deregulated Nutrient Sensing | Critically ill patients often present increased insulin resistance and stress-induced hyperglycemia. | 22917085 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular risk factors were mainly smoking (60.5%), dyslipidaemia (46.0%), diabetes (51.4%) and hypertension (56.0%). | 22917780 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | This first longitudinal study of GDF-15 in a large cohort of obese individuals indicates that GDF-15 is related to abdominal obesity and insulin resistance and independently associated with future insulin resistance and abnormal glucose control. | 22918303 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Children and young adults treated with total body or abdominal radiotherapy have an increased risk of insulin resistance and diabetes mellitus. | 22921663 |
| Reproductive dehiscence, Vascular Diseases, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | This is the first reported case of ALGS with TOF/PA/MAPCAs and catastrophic shunt dehiscence due to significant generalized vasculopathy caused by dyslipidemia and atherosclerosis. | 22923029 |
| Dyslipidemias, Comorbidity | Deregulated Nutrient Sensing | Dyslipidemia, a known comorbidity in ALGS, is one of few modifiable risk factors that should be screened for and treated, particularly before cardiac surgery. | 22923029 |
| Lichen Planus, Dyslipidemias | Deregulated Nutrient Sensing | Recently, a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients. | 22924867 |
| Sensorineural Hearing Loss (disorder), Myoclonus, Leukoencephalopathy, Myopathy, Hypertrophic Cardiomyopathy | Deregulated Nutrient Sensing | Sporadic myopathy, myoclonus, leukoencephalopathy, neurosensory deafness, hypertrophic cardiomyopathy and insulin resistance associated with the mitochondrial 8306 T>C MTTK mutation. | 22925535 |
| Autoimmune Diseases, Primary malignant neoplasm, Metabolic Diseases, Obesity | Deregulated Nutrient Sensing | Insufficient vitamin D status has been linked to autoimmune diseases, cancer and metabolic disorders, like obesity and insulin resistance. | 22925537 |
| diabetic | Deregulated Nutrient Sensing | We previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats. | 22930403 |
| Dyslipidemias, Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | It has been long suggested that abnormal clinical factors in the body, such as dyslipidemia and diabetes, can affect the presence of atherosclerosis. | 22931970 |
| Nausea, Weight decreased | Deregulated Nutrient Sensing | Exenatide demonstrated more beneficial effects on HbA(1C), weight reduction and insulin resistance during 26 weeks of treatment, but there were more hypoglycemic events and mild-to-moderate nausea compared with metformin. | 22931974 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Relationships of the Mediterranean dietary pattern with insulin resistance and diabetes incidence in the Multi-Ethnic Study of Atherosclerosis (MESA). | 22932232 |
| Metabolic Syndrome X, Cardiovascular morbidity, Prostate Cancer Outcomes Study, Diabetes Mellitus, Hyperandrogenism, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Hyperandrogenism and insulin resistance are also key features of polycystic ovary syndrome (PCOS), and women with PCOS are consequently at an increased risk of developing type 2 diabetes mellitus and/or metabolic syndrome, and may have increased cardiovascular morbidity. | 22933528 |
| Dyslipidemias | Deregulated Nutrient Sensing | A central/visceral fat distribution and excess free fatty acid (FFA) availability are associated with dyslipidemia and insulin resistance. | 22933539 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | No associations were observed between NAE and cardiovascular risk factors, such as hypertension and insulin resistance. | 22935845 |
| Glucose Intolerance (disease), Liver diseases, Malignant Neoplasms, Hyperuricemia | Deregulated Nutrient Sensing | This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. | 22937763 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | A total of 1360 (8.5%) NOD cases were identified among 16,027 patients with hypertension and dyslipidemia during the study period. | 22939164 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | These outpatients with hypertension and dyslipidemia who took fluvastatin, lovastatin, and rosuvastatin were at lower risk of NOD, whereas patients who took pravastatin were at greater risk. | 22939164 |
| Dyslipidemias | Deregulated Nutrient Sensing | Factors related to the presence of RAS were diastolic blood pressure, glomerular filtration rate and dyslipidaemia. | 22939809 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Waist circumference (WC), a surrogate indicator of abdominal fat mass, is used to measure central obesity associated with increased risk of hypertension, insulin resistance and type 2 DM, whereas body mass index (BMI) is traditionally used to measure somatic obesity. | 22941134 |
| Inflammation, Insufficiency | Deregulated Nutrient Sensing | And microinflammation and insulin resistance are closely correlated with the insufficiency and deficiency of 25(OH)D. The independent influencing factors of serum 25(OH)D are hsCRP, RI, LDL and age. | 22944160 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of overweight/obesity and dyslipidaemia observed in these children is a matter of concern considering the age group evaluated. | 22946122 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Effects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease: rationale and design of the ASsessment of clinical Usefulness in CKD patients with Atorvastatin (ASUCA) trial. | 22948416 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Since dyslipidemia has been shown to be an independent risk factor for the progression of chronic kidney disease (CKD), low-density lipoprotein cholesterol (LDL-C)-lowering therapy can be potentially associated with inhibition of CKD progression. | 22948416 |
| Metabolic Diseases, Obesity | Deregulated Nutrient Sensing | Leptin, however, strongly correlated with insulin resistance independently of fat masses, suggesting that obesity, as a metabolic disorder risk factor, affects glucose metabolism, partly through the role of leptin. | 22948754 |
| Dyslipidemias | Deregulated Nutrient Sensing | Development and evaluation of a simple and effective prediction approach for identifying those at high risk of dyslipidemia in rural adult residents. | 22952780 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is an extremely prevalent but preventable risk factor for cardiovascular disease. | 22952780 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, many dyslipidemia patients remain undetected in resource limited settings. | 22952780 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Some risk factors were significantly associated with dyslipidemia, including age, gender, educational level, smoking, high-fat diet, vegetable and fruit intake, family history, physical activity, and central obesity. | 22952780 |
| Type II Endometrial Adenocarcinoma | Deregulated Nutrient Sensing | The mammalian target of rapamycin in the nuclei (mTORC2; 47%) or cytoplasm (mTORC1; 48%) were seen in type II endometrial carcinoma, the latter also in advanced stages (P <= .046). | 22955108 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Phosphorylated AMP-activated protein kinase expression associated with prognosis for patients with gastric cancer treated with cisplatin-based adjuvant chemotherapy. | 22955258 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | NAFLD patients were older, had higher BMI, larger waist circumference, higher sum of skinfolds, more likely to have insulin resistance (HOMA > 3.0) and type-2 diabetes (all P-values <0.01). | 22958053 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in b cells and mice. | 22960655 |
| Glucose Intolerance (disease), Pancreatic carcinoma | Deregulated Nutrient Sensing | Conversely, overexpression of adrenomedullin in mice with pancreatic cancer led to glucose intolerance. | 22960655 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Iron metabolism is associated with adipocyte insulin resistance and plasma adiponectin: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study. | 22961568 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Adipocyte insulin resistance (IR) is a key feature early in the pathogenesis of type 2 diabetes mellitus (T2DM), and although scarce, data in the literature suggest a direct role for iron and iron metabolism-related factors in adipose tissue function and metabolism. | 22961568 |
| Dyslipidemias | Deregulated Nutrient Sensing | Subjects with dyslipidemias and T2DM had, respectively, 2.3 and 2.6-fold higher sd-LDL-C concentrations than normolipidemic individuals (p<0.05). | 22962227 |
| TG gene | Deregulated Nutrient Sensing | GERD symptoms were correlated with insulin resistance (r = 0.167, p = 0.011), total cholesterol (T-CHO) (r = 0.138, p = 0.034), triglyceride (TG) (r = 0.178, p = 0.006), or immunoreactive insulin (r = 0.173, p = 0.008) but not BMI (r = 0.089, p = 0.175). | 22964626 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Association of the apolipoprotein B/apolipoprotein A-I ratio and low-density lipoprotein cholesterol with insulin resistance in a Chinese population with abdominal obesity. | 22965469 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort. | 22966089 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and truncal obesity account for the twofold excess incidence of diabetes in Indian Asian and African Caribbean women, but not men. | 22966089 |
| Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Chronic disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The top four relevant chronic diseases of stroke patients were hypertension, dyslipidemia, obesity and diabetes mellitus. | 22968008 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Beyond atherogenic dyslipidemia, high-Trg/normal HDL-cholesterol category was associated with elevated CRP and diabetes risk in women. | 22968297 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Elevated insulin and insulin resistance are associated with the advanced pathological stage of prostate cancer in Korean population. | 22969256 |
| Prostate carcinoma | Deregulated Nutrient Sensing | These results suggest that elevated insulin and insulin resistance are associated with the advanced pathological stage of prostate cancer in Korean patients. | 22969256 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Adherence rates to recommended guidelines for coronary artery disease, hypertension, and dyslipidemia were high (>75%); however <50% of patients were at target for blood pressure or LDL-cholesterol levels (37.1% and 49.7% respectively), and only 59.3% of patients with diabetes were at target for hemoglobin-A1c. | 22970753 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | Despite high adherence rates for hypertension, dyslipidemia, and coronary artery disease, a significant proportion of patients failed to meet treatment targets, highlighting the complexity of caring for people with multiple chronic conditions. | 22970753 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Serum gamma-glutamyltransferase (GGT) levels, which are associated with insulin resistance, may predict the incidence of cardiovascular disease and mortality. | 22972431 |
| Pulmonary arterial hypertension, Polycyclic Hydrocarbons, Aromatic | Deregulated Nutrient Sensing | Patients with pulmonary arterial hypertension (PAH) exhibit impaired glucose metabolism and increased insulin resistance. | 22975101 |
| Gastroesophageal reflux disease, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects undergoing treatment for hypertension showed an increased risk of GERD, while those undergoing treatment for dyslipidemia and diabetes mellitus showed a decreased risk. | 22976934 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Of these risk factors, hypertension and dyslipidemia are significantly associated with increased cIMT. | 22977209 |
| Obesity, Abdominal, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Older age, male gender, metabolic factors such as obesity, abdominal obesity, dyslipidemia, hypertension or type 2 diabetes are risk factors for NAFLD. | 22978800 |
| Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | [Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation]. | 22980663 |
| Atrial Fibrillation, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | To observe the expression of mammalian sirtuin 1 (SIRT1) in right auricle tissues in patients presenting with atrial fibrillation (AF) and make clear the relationship between SIRT1 expression and oxidative stress. | 22980663 |
| SLC25A20 gene, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In conclusion, these data indicate that abnormal calcium and phosphate metabolism, insulin resistance, and declining kidney function are associated with the prevalence of high CAC, independent of the traditional risk factors in patients with CKD. | 22980963 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Conventional atherosclerotic markers and LDL particle size (LDL-PS), as determined by gel electrophoresis, were measured in 155 non-diabetic subjects (mean age of 57 years) with dyslipidemia. | 22981508 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that high PG levels may contribute to the HDL oxidation, irrespective of HDL-cholesterol levels, even in non-diabetic subjects with dyslipidemia, and that the measurement of oxHDL may be a useful marker of dysfunctional HDL. | 22981508 |
| Keloid | Deregulated Nutrient Sensing | Keloid disease can be inhibited by antagonizing excessive mTOR signaling with a novel dual TORC1/2 inhibitor. | 22982188 |
| Dyslipidemias, Brain hemorrhage, Cerebrovascular accident, Deglutition Disorders, Hypertension, CTCAE | Deregulated Nutrient Sensing | Presence of limb weakness, dysphagia, dyslipidemia, hypertension, hemorrhagic stroke, severe stroke, and poor outcome predicted the use of CAM. | 22982825 |
| Non-insulin Hypoglycemic | Deregulated Nutrient Sensing | There were also significant differences of mean on fat mass, fat mass (%), waist circumference, peripheral subcutaneous fat, trunk subcutaneous fat, which were significantly higher in insulin-resistance group compared to the non-insulin resistance group. | 22983074 |
| Hypertriglyceridemia, Dyslipidemias, Hypercholesterolemia, Familial | Deregulated Nutrient Sensing | Hyperbetalipoproteinemia, hypertriglyceridemia, dyslipidemia, impaired glucose tolerance (IGT), and WCH had a similar fashion with excess weight by increasing until the seventh decade and decreasing afterwards (p<0.05 nearly in all steps). | 22983077 |
| Sleep Apnea, CTCAE, Acromegaly | Deregulated Nutrient Sensing | Sleep Apnea is highly prevalent and may contribute to insulin resistance in patients with acromegaly. | 22983689 |
| Obesity | Deregulated Nutrient Sensing | The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents. | 22984471 |
| Obesity | Deregulated Nutrient Sensing | Upper tCys quartile was independently associated with a 5-fold increased risk of obesity (95% CI 3.5-8.0, P<0.001), and 2-fold risk of insulin resistance (95% CI: 1.6-5.0, P<0.001; adjusted for body fat%). | 22984471 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Adipose tissue insulin resistance in peripubertal girls with first-degree family history of polycystic ovary syndrome. | 22985947 |
| Prostate Cancer Outcomes Study, Lipolysis | Deregulated Nutrient Sensing | Girls at high risk of developing PCOS display increased adiposity and 17-OHP levels, but are mainly characterized by global insulin resistance and resistance to insulin-induced suppression of lipolysis that were independent of adiposity and 17-OHP levels. | 22985947 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Therefore, genetic predisposition to PCOS may be related to early insulin resistance and adipocyte dysfunction. | 22985947 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Total OSI associated significantly with DM type 2, arterial hypertension, and dyslipidemia in both genders. | 22986427 |
| Malignant tumor of colon | Deregulated Nutrient Sensing | In addition, in vitro studies were performed using colon cancer cell lines to study the serial changes of LKB1, LGR5 and PRKAA1 (AMPK) gene expression levels after irradiation. | 22986809 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | In conclusion, GSPE increase eNOS expression and NO production in an AMPK/SIRT1 dependent manner through KLF2 induction, and attenuate ouabain induced hypertension. | 22987017 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Dietary patterns are associated with insulin resistance in Chinese adults without known diabetes. | 22989490 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, dietary patterns were significantly associated with insulin resistance in Chinese adults without known diabetes. | 22989490 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | A dysfunctional adiposity phenotype, characterized by excess visceral fat and insulin resistance, may contribute to diabetes development in those with obesity. | 22990274 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Excess visceral fat and insulin resistance, but not general adiposity, were independently associated with incident prediabetes and type 2 diabetes mellitus in obese adults. | 22990274 |
| Nucleus Pulposus | Deregulated Nutrient Sensing | SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. | 22990594 |
| Autoimmune Diseases | Deregulated Nutrient Sensing | Among DA-positive youth, there was a progressive decline in beta cell function of 4% per month, independent of demographics (age, sex, race/ethnicity), genetic susceptibility to autoimmunity (HLA risk), HbA(1c) and BMI z score, or presence of insulin resistance. | 22990715 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Diabetic patients with a positive stress test showed higher prevalence of hypertension (36%) and dyslipidaemia (84%) compared with diabetic patients with a negative stress test (12% and 28%, respectively) [p < 0.001]. | 22994582 |
| Dyslipidemias | Deregulated Nutrient Sensing | Analysis 2: comparable rates of dyslipidaemia to SPANS 2004 but lower rates compared to the AHFS, 1985. | 22998088 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is one of the most modifiable risk factors in preventing heart disease. | 22998096 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Evidence demonstrates that the process of atherosclerosis, a result of dyslipidemia, begins in young adults. | 22998096 |
| Hypertension, CTCAE, Obesity, Cerebrovascular accident | Deregulated Nutrient Sensing | Chronic arterial stiffness contributes to the negative health effects of obesity and insulin resistance, which include hypertension, stroke, and increased cardiovascular and all-cause mortality. | 22998737 |
| Non-alcoholic Fatty Liver Disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | These results support a beneficial effect of the non-alcoholic fraction of red wine (mainly polyphenols) on insulin resistance, conferring greater protective effects on cardiovascular disease to red wine than other alcoholic beverages. | 22999066 |
| Electrocardiogram: myocardial infarction (finding), Endothelial dysfunction | Deregulated Nutrient Sensing | In young post-myocardial infarction male patients elevated plasminogen activator inhibitor-1 correlates with insulin resistance and endothelial dysfunction. | 23001714 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | The aim of the present study was to find out whether insulin resistance and impaired fibrinolysis, with increased plasminogen activator inhibitor (PAI-1), are present in young male post-MI patients, and their relation to additional markers of cardiovascular risk such as endothelial dysfunction (ED) and intima-media thickness (IMT). | 23001714 |
| Obesity | Deregulated Nutrient Sensing | Our results suggest that PAI-1 can be a link between obesity, insulin resistance, and MI in young patients. | 23001714 |
| Ancriviroc, Steatohepatitis | Deregulated Nutrient Sensing | However, the emergence of anti-CL in CH-C patients was independent of insulin resistance, hepatic steatosis, and iron overload. | 23001979 |
| Atherosclerosis, Aortic Aneurysm, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with ascending aortic aneurysms had 0.131-mm lower carotid IMT values than controls (p = 0.0002), independent of risk factors for atherosclerosis (age, BMI, gender, family history, smoking, dyslipidemia, race, diabetes and hypertension). | 23006774 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | BMI, male gender, positive family history, dyslipidemia, diabetes and hypertension also increased the IMT, but did not reach statistical significance. | 23006774 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | We conclude that plasma BNP levels are determined primarily by cardiac production and that insulin resistance is a significant predictor of cardiac BNP production independent of LV hypertrophy in obese individuals. | 23006812 |
| Anxiety, CTCAE 3.0, Hypertensive (finding), Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance (HOMA), Doppler Renal Resistive Index (RRI) and glomerular filtration rate (GFR) are studied along with Psychological Stress Measure (PSM), Illness Perception Questionnaire (IPQ-R), Generalized Self-Efficacy scale (GSE) and Hospital Anxiety and Depression Scale (HADS) in 119 hypertensive patients referred for stable lasting EH, and 150 normal controls. | 23007813 |
| Obesity | Deregulated Nutrient Sensing | By Odds Ratios, higher risk of EH is associated with greater perceived stress, older age, lower GFR, obesity, greater RRI and insulin resistance. | 23007813 |
| Hypertriglyceridemia, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertriglyceridemia and residual dyslipidemia in statin-treated, patients with diabetes at the highest risk for cardiovascular disease and achieving very-low low-density lipoprotein-cholesterol levels. | 23009779 |
| Dyslipidemias | Deregulated Nutrient Sensing | The only LDL-C at goal group had lower HDL-C (vs. all three at goal): 41 (12) vs. 47 (14) mg/dL (P = .0237), with atherogenic dyslipidemia [hypo-HDL-C + hyper-TG] prevalence of 35% in the all three at goal versus 56% in the only LDL-C at goal group (P < .0001). | 23009779 |
| Hypercholesterolemia, Dyslipidemias, Failure (biologic function) | Deregulated Nutrient Sensing | The presence of atherogenic dyslipidemia was associated with a failure to meet all three critical modifiable targets for hypercholesterolemia, such a nonachievement being found in a large proportion (one-third) of very-high risk T2DM patients with very-low on-statin LDL-C. Attainment of all three targets will require (1) titration/permutation of statins, (2) lifestyle (re)inforcement; and/or (3) statin-fibrate bitherapy. | 23009779 |
| Diabetes, Autoimmune | Deregulated Nutrient Sensing | Our findings indicate that psychosocial factors influence the risk of autoimmune diabetes in adults, possibly through mechanisms related to insulin resistance. | 23010555 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | People with metabolically obese, normal-weight (MONW) phenotype, characterized by insulin resistance, are vulnerable to cardiovascular disease even though they are not physically obese. | 23010880 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Individuals at risk of developing type 2 diabetes show a progressive decline in insulin secretion and increased insulin resistance over time. | 23011353 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, inability of the beta cells to compensate for the increased insulin resistance represents a key defect leading to overt type 2 diabetes. | 23011353 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | A-FABP (adipocyte fatty acid-binding protein), one of the most abundant proteins in adipocytes, plays a key role in obesity-related insulin resistance, inflammation and atherosclerosis in animals. | 23013043 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The most prevalent risk factors were being overweight (70% of patients had a BMI over 25), dyslipidaemia (70% of patients) and smoking (43% of patients). | 23013637 |
| Prostate Cancer Outcomes Study, Complication Aspects | Deregulated Nutrient Sensing | Omega-3 fatty acids had some beneficial effects on serum adiponectin levels, insulin resistance and lipid profile in PCOS patients and may contribute to the improvement of metabolic complications in these patients. | 23017309 |
| Loss | Deregulated Nutrient Sensing | Loss continues into old age (24 months) and is inversely correlated with the development of insulin resistance. | 23020201 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Gender distribution of risk factors showed that hypertension and dyslipidemia are major risk factors in group 1. | 23022901 |
| Dyslipidemias | Deregulated Nutrient Sensing | Total cholesterol, low-density lipoprotein cholesterol and triglycerides decreased to near-optimal values in dyslipidaemia patients. | 23023902 |
| Liver carcinoma, Liver neoplasms | Deregulated Nutrient Sensing | SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas. | 23024800 |
| Neoplasms | Deregulated Nutrient Sensing | The increased expression of SIRT1 has recently been identified in numerous human tumors and a possible correlation with c-Myc oncogene has been proposed. | 23024800 |
| Neoplasms | Deregulated Nutrient Sensing | However, it remains unclear whether SIRT1 functions as an oncogene or tumor suppressor. | 23024800 |
| Malignant neoplasm of liver, Liver carcinoma | Deregulated Nutrient Sensing | We sought to elucidate the role of SIRT1 in liver cancer under the influence of c-Myc and to determine the prognostic significance of SIRT1 and c-Myc expression in human hepatocellular carcinoma. | 23024800 |
| Malignant neoplasm of liver | Deregulated Nutrient Sensing | The effect of either over-expression or knock down of SIRT1 on cell proliferation and survival was evaluated in both mouse and human liver cancer cells. | 23024800 |
| Liver carcinoma | Deregulated Nutrient Sensing | The prognostic significance of the immunohistochemical detection of SIRT1 and c-Myc was evaluated in 154 hepatocellular carcinoma patients. | 23024800 |
| Liver neoplasms | Deregulated Nutrient Sensing | SIRT1 and c-Myc regulate each other via a positive feedback loop and act synergistically to promote hepatocellular proliferation in both mice and human liver tumor cells. | 23024800 |
| Liver carcinoma | Deregulated Nutrient Sensing | In human hepatocellular carcinoma, SIRT1 expression positively correlated with c-Myc, Ki67 and p53 expression, as well as high a-fetoprotein level. | 23024800 |
| Liver carcinoma | Deregulated Nutrient Sensing | Moreover, the expression of SIRT1, c-Myc and p53 were independent prognostic indicators of hepatocellular carcinoma. | 23024800 |
| Neoplastic Cell Transformation | Deregulated Nutrient Sensing | In conclusion, this study demonstrates that SIRT1 expression supports liver tumorigenesis and is closely correlated with oncogenic c-MYC expression. | 23024800 |
| Liver carcinoma | Deregulated Nutrient Sensing | In addition, both SIRT1 and c-Myc may be useful prognostic indicators of hepatocellular carcinoma and SIRT1 targeted therapy may be beneficial in the treatment of hepatocellular carcinoma. | 23024800 |
| Proteinuria, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | They also had a higher prevalence of hypertension (P = .001), dyslipidemia (P = .004) and proteinuria (P = .001). | 23026595 |
| Obesity | Deregulated Nutrient Sensing | Parathyroid hormone and insulin resistance in distinct phenotypes of severe obesity: a cross-sectional analysis in middle-aged men and premenopausal women. | 23027922 |
| Units Of Measure - Siemens | Deregulated Nutrient Sensing | MHO (n = 43) and IRO (n = 86) subjects were identified according to quartiles of insulin resistance. | 23027922 |
| Demographics Domain, Seizures, Dyslipidemias, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Co-morbid DM with SZ predicted worse overall cognitive performance and lower scores for three cognitive domains (vigilance, processing speed, and reasoning), but none of the other metabolic factors (i.e., obesity, hypertension and dyslipidemia) correlated with cognitive function in SZ. | 23031192 |
| Heart Diseases, Endothelial dysfunction | Deregulated Nutrient Sensing | Insulin resistance (IR) and endothelial dysfunction are frequently associated in cardiac disease. | 23031426 |
| Obesity | Deregulated Nutrient Sensing | Correction for variables of obesity and insulin resistance almost completely abrogated this difference in endocannabinoids. | 23032139 |
| Inflammation, Sleep Apnea, CTCAE, Obesity | Deregulated Nutrient Sensing | In multivariate regression analysis, anandamide was a stronger determinant of blood pressure than sleep apnea severity, obesity, insulin resistance, and inflammation. | 23032139 |
| Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | The glycemic response to gastric bypass is related to BMI, duration of diabetes, fasting C-peptide (influenced by insulin resistance and residual b-cell function), and weight loss. | 23033249 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Case-control study of markers of insulin resistance and endometrial cancer risk. | 23033315 |
| Primary malignant neoplasm, Malignant neoplasm of endometrium, Obesity | Deregulated Nutrient Sensing | This population-based study provides evidence for a role of insulin resistance in endometrial cancer etiology and may provide one possible pathway whereby obesity increases the risk of this common cancer. | 23033315 |
| Malignant neoplasm of endometrium, Obesity | Deregulated Nutrient Sensing | Interventions aimed at decreasing both obesity and insulin resistance may decrease endometrial cancer risk. | 23033315 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hematopoietic cell transplantation (HCT) recipients may be at an increased risk of developing hypertension, diabetes, and dyslipidemia (referred to as cardiovascular risk factors [CVRFs]); and these factors can potentially increase the risk of cardiovascular disease (CVD). | 23034279 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | History of grade II-IV acute graft versus host disease was associated with an increased risk for hypertension (relative risk [RR] = 9.1, P < .01), diabetes (RR = 5.8, P < .01), and dyslipidemia (RR = 3.2, P < .01); conditioning with total body irradiation was associated with an increased risk of diabetes (RR = 1.5, P = .01) and dyslipidemia (RR = 1.4, P < .01). | 23034279 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance and the risk of stroke and stroke subtypes in the nondiabetic elderly. | 23035021 |
| Diabetes Mellitus, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance, which plays a key role in the development of diabetes mellitus, is a putative modifiable risk factor for stroke. | 23035021 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Cox regression was used to determine associations between insulin resistance markers and stroke risk, adjusted for age, sex, and potential confounders. | 23035021 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | In conclusion, in this population-based cohort study among nondiabetic elderly, insulin resistance markers were not associated with risk of stroke or any of its subtypes. | 23035021 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Personal attributes that influence the adequate management of hypertension and dyslipidemia in patients with type 2 diabetes. | 23035799 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are often insufficiently controlled in persons with type 2 diabetes (T2D) in Germany. | 23035799 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) is a metabolic disorder that is increasing worldwide and has been associated with several negative health outcomes. | 23037180 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Global fat mass distribution seems to correlate with different levels of cardio-metabolic risk; centrally distributed fat carries a high risk of cardiovascular disease, while lower limb adiposity may have a protective effect against insulin resistance. | 23037332 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The insulin resistance observed was similar among age-, sex- and body mass index-matched individuals with and without CKD. | 23043683 |
| CLU protein, human, Dyslipidemias | Deregulated Nutrient Sensing | Furthermore, overall secondary patency rates remain within the standard limits, although preoperative CLI and dyslipidemia continue to be associated with worse outcomes. | 23044257 |
| Fetal Growth Retardation | Deregulated Nutrient Sensing | The homozygous mutation of the IGF1R is associated with severe IUGR, dysmorphic features, and insulin resistance, while both parents were asymptomatic heterozygous carriers of the same mutation. | 23045302 |
| Colorectal Carcinoma, S100A4 protein, human | Deregulated Nutrient Sensing | Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. | 23045412 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | The expression of c-MYC and SIRT1 correlated with the presence of KRAS and BRAF mutations and high expression of c-MYC and SIRT1 was strongly associated with higher grades of malignancy. | 23045412 |
| Serrated Nodule | Deregulated Nutrient Sensing | In contrast, in the majority of serrated lesions without KRAS or BRAF mutations, c-MYC and SIRT1 expression was not found increased. | 23045412 |
| Carcinoma, Intraepithelial Neoplasia | Deregulated Nutrient Sensing | In this group only a subset of mostly high grade intraepithelial neoplasia and carcinoma was characterized by elevated c-MYC and SIRT1 expression. | 23045412 |
| Serrated Nodule, Colorectal Carcinoma, Malignant Neoplasms | Deregulated Nutrient Sensing | The increasing expressions with higher grades of malignancy suggest crucial functions for c-MYC and SIRT1 in the progression of serrated lesions to colorectal cancer. | 23045412 |
| Polycystic Ovary Syndrome, Prostate Cancer Outcomes Study, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Women with polycystic ovary syndrome (PCOS) are potentially at increased risk of cardiovascular (CV) diseases due to well-established risk factors, including insulin resistance, obesity and type 2 diabetes mellitus (T2DM). | 23046078 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Postprandial glucose, fasting insulin and insulin resistance were elevated in women with PCOS. | 23046530 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Apart from their role in cardiovascular homeostasis and immunomodulation, aldosterone and cortisol are also implicated in the pathogenesis of insulin resistance and type 2 diabetes mellitus (T2DM). | 23047828 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Endocrine therapy resistance is in part mediated by insulin resistance in obese women with breast cancer. | 23053261 |
| Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, Hypertension, CTCAE | Deregulated Nutrient Sensing | A retrospective analysis of immediate outcome was performed of patients undergoing right hepatectomy and affected by two or more metabolic disorders (diabetes mellitus, hypertension, dyslipidemia, obesity/overweight) without any other known cause of liver disease from January 2001 to May 2010. | 23054903 |
| Weight decreased | Deregulated Nutrient Sensing | Lifestyle intervention improved insulin resistance, decreased ADMA, and increased ghrelin in obese subjects with IR although no significant weight loss was observed. | 23055013 |
| ARCN1 gene, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | In the univariate risk analysis, COPD, hypertension, diabetes, obesity, and dyslipidemia were risk factors for ischemic heart disease. | 23055717 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. | 23057846 |
| Endothelial dysfunction, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim of the present study was to determine whether the endothelial dysfunction associated with CAD (coronary artery disease) and T2D (Type 2 diabetes mellitus) is concomitant with elevated mtROS (mitochondrial reactive oxygen species) production in the endothelium and establish if this, in turn, regulates the activity of endothelial AMPK (AMP-activated protein kinase). | 23057846 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Levels of mitochondrial H(2)O(2) and activity of AMPK were significantly elevated in primary HSVECs (human saphenous vein endothelial cells) from patients with CAD and T2D compared with those from patients with CAD alone. | 23057846 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Incubation with the mitochondria-targeted antioxidant, MitoQ(10) significantly reduced AMPK activity in HSVECs from patients with CAD and T2D but not in cells from patients with CAD alone. | 23057846 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Elevated mtROS production in the endothelium of patients with CAD and T2D increases AMPK activation, supporting a role for the kinase in defence against oxidative stress. | 23057846 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Further investigation is required to determine whether pharmacological activators of AMPK will prove beneficial in the attenuation of endothelial dysfunction in patients with CAD and T2D. | 23057846 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To evaluate the impact on glycemic control, insulin secretion and on insulin resistance of a sitagliptin + metformin combination compared to metformin monotherapy in type 2 diabetic, naive to treatment, patients. | 23061989 |
| Depression, CTCAE | Deregulated Nutrient Sensing | In addition, patients with depression have insulin resistance during testing tolerance to insulin, and during testing tolerance to glucose. | 23062454 |
| Hyperglycemia, Critical Illness | Deregulated Nutrient Sensing | Critically ill patients often experience high levels of insulin resistance and stress-induced hyperglycemia, which may negatively impact outcomes. | 23063028 |
| Inflammation, Heart failure | Deregulated Nutrient Sensing | Although plasma palmitoleic acid has been positively associated with blood pressure, inflammation, and insulin resistance, its association with heart failure has not been investigated. | 23065037 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The elevated fetuin-A levels could have a clinical implication in the increased cardiovascular risk and insulin resistance associated with NAFLD and IGT. | 23066121 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X, Atherosclerosis | Deregulated Nutrient Sensing | The liver-secreted protein fetuin-A is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. | 23067229 |
| Apolipoproteins B | Deregulated Nutrient Sensing | The CR group also showed a significant decrease in apolipoprotein B, leptin and insulin resistance compared to those in the control group, although endothelial function was not different. | 23067229 |
| Vascular Diseases | Deregulated Nutrient Sensing | The independent role of insulin resistance (IR) and high fasting blood glucose (FBG) levels within the normal range on vascular diseases is still under debate. | 23067236 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Of the 52 patients, 61.5% had hypertension and 59.6% had dyslipidemia. | 23068107 |
| Hyperglycemia, Cardiac complication, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The improvement after surgery in hyperglycemia, hypertension, and dyslipidemia could help in controlling the occurrence of micro- and macrovascular complications and decrease the morbidity and mortality associated with T2DM. | 23068107 |
| Glucose Intolerance (disease), Gonadotropin deficiency, Cardiomyopathies, Arthropathy | Deregulated Nutrient Sensing | He had no signs of cardiomyopathy, gonadal insufficiency, arthropathy, or glucose intolerance. | 23069304 |
| Atrophic | Deregulated Nutrient Sensing | Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. | 23069842 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Insulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease. | 23069842 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Insulin resistance may play a role in Alzheimer disease etiopathogenesis. | 23069842 |
| Temporal Lobe | Deregulated Nutrient Sensing | A region-of-interest analysis, independent of the voxel-wise analyses, confirmed that higher insulin resistance was related to medial temporal lobe atrophy. | 23069842 |
| Temporal Lobe | Deregulated Nutrient Sensing | Temporal lobe atrophy that was predicted by higher insulin resistance significantly mediated worse RAVLT encoding performance. | 23069842 |
| Alzheimers Disease", Atrophic | Deregulated Nutrient Sensing | These results suggest that insulin resistance in an asymptomatic, late middle-aged cohort is associated with progressive atrophy in regions affected by early Alzheimer disease. | 23069842 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation. | 23070058 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Decreased SIRT1 protein levels were observed in EPCs from type 2 diabetic patients compared with control individuals (p < 0.01). | 23070058 |
| Hyperglycemia, Peripheral vascular complication, Diabetes Mellitus | Deregulated Nutrient Sensing | These findings unveil a link between PAF and SIRT1 pathways in EPCs that contributes to the deleterious effect of hyperglycaemia on the functional properties of EPCs, crucial in diabetes and peripheral vascular complications. | 23070058 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Haiti, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with type 2 diabetes mellitus (T2DM) frequently have other common diseases such as hypertension (HT), dyslipidemia (DL), and cardiovascular disease (CVD). | 23073638 |
| Metabolic Diseases, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Present-day SK diseases are often accompanied with marked systemic metabolic disorders (obesity, dyslipidemia, androgen deficiency). | 23074925 |
| Dyslipidemias, Chronic Kidney Diseases, Obesity | Deregulated Nutrient Sensing | We believe that early detection and pathogenetic correction of dyslipidemia, obesity and androgen deficiency in SK men may be key prophylactic factors of SK diseases which often entail development of chronic renal failure. | 23074925 |
| Dyslipidemias, Cardiovascular Abnormalities, Atherosclerosis | Deregulated Nutrient Sensing | CONCLUSIONS--The study revealed an increased risk of cardiovascular abnormalities and an increased risk of atherosclerosis: 65,61% subjects were obese, 90,6% with high blood pressure, 62,5% had dyslipidaemia. | 23077929 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin-like growth factor-1 (IGF-1) is involved in the pathogenesis of insulin resistance (IR) and T2D. | 23078161 |
| Complication Aspects, Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Lipodystrophy | Deregulated Nutrient Sensing | HIV-positive patients receiving combination antiretroviral therapy (cART) frequently experience metabolic complications such as dyslipidemia and insulin resistance, as well as lipodystrophy, increasing the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). | 23078769 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Short sleep duration is associated with hypertension and diabetes; however, its association with dyslipidemia is not well known. | 23081691 |
| Dyslipidemias, Osage language | Deregulated Nutrient Sensing | Percent sleep time of oxygen saturation as measured by pulse oximetry (SpO2) < 90% and prevalence of severe OSA were greater and sleep duration and mean SpO2 during sleep were lower in subjects with dyslipidemia than in those without. | 23081691 |
| Obesity | Deregulated Nutrient Sensing | Raised levels of circulating LPS can trigger an increase in chronic pro-inflammatory cytokines, which may mediate the development of insulin resistance and obesity. | 23082944 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Almost 80% of PCI patients were overweight (body mass index >=25 kg/m(2)), 80% had dyslipidemia, and 27.6% were current or recent smokers. | 23083784 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The association of fatty acid composition with insulin resistance and type 2 diabetes has been reported in Western populations, but there is limited evidence of this association among the Japanese, whose populace consume large amounts of fish. | 23084639 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Finally, 2 months of therapy with the antidiabetic drug metformin significantly inhibited the maturation of IL-1b in MDMs from patients with type 2 diabetes through AMP-activated protein kinase (AMPK) activation. | 23086037 |
| diabetic | Deregulated Nutrient Sensing | Therefore, we evaluated its effect on insulin sensitivity since there is a quest for studies that focus at better understanding of insulin resistance aspects in diabetic patients. | 23088514 |
| diabetic | Deregulated Nutrient Sensing | The supplementation used decreased insulin resistance in type 2 diabetic patients, suggesting a positive action in blood glucose control as adjuvant therapy in conventional treatments. | 23088514 |
| Tumor necrosis | Deregulated Nutrient Sensing | Insulin resistance, C-reactive protein, tumour necrosis factor a, and interleukin 6 decreased across omega-3 PUFA tertiles among the Health 2000 survey participants. | 23089109 |
| Arterial Stiffness, Carotid Artery Plaque | Deregulated Nutrient Sensing | Among the Fishermen study men, insulin resistance and arterial stiffness indicated by b-stiffness index tended to increase and the RR estimate for carotid artery plaque tended to decrease across tertiles of PCDD/F+PCB and MeHg. | 23089109 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Elevated PAI-1 concentrations have been implicated in the pathogenesis of such aging-related conditions as insulin resistance, obesity, and atherosclerosis. | 23089338 |
| Dyslipidemias, Obesity, Hypertensive disease, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and is associated with obesity, dyslipidemias, hypertension (HTN) and type 2 diabetes mellitus (T2DM). | 23089926 |
| Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | Women reported being more likely to eat healthy, but also were more likely to have a physician diagnosis of high blood pressure, dyslipidemia, osteoporosis and overall poor health status. | 23090310 |
| Diabetes Mellitus, Non-Insulin-Dependent, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. | 23090577 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity is the major determinant of type 2 diabetes (T2D), presumably through its effect on insulin resistance. | 23090577 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Genetic predisposition to obesity contributes to increased insulin resistance and to its compensation through increased b-cell function, and weakly increases the T2D risk. | 23090577 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Adipose tissue is an active endocrine organ that secretes various metabolically important substances including adipokines, which represent a link between insulin resistance and nonalcoholic steatohepatitis (NASH). | 23091808 |
| Impaired T cell function | Deregulated Nutrient Sensing | In conclusion, common variation in MAP4K4 is associated with insulin resistance and b-cell dysfunction, possibly via this gene's role in inflammatory signalling. | 23094072 |
| Metabolic Diseases, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The most common metabolic disorders were: obesity (68% in men with TT levels >350 ng/dL and 91% in men with TT levels <350 ng/dL) and dyslipidemia (54 and 95%, respectively). | 23094956 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Testosterone deficiency was very common in population of Polish men presenting with EDs and correlated negatively with age, obesity and dyslipidemia. | 23094956 |
| Apolipoprotein E, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | High serum apolipoprotein E determines hypertriglyceridemic dyslipidemias, coronary disease and apoA-I dysfunctionality. | 23096223 |
| Apolipoprotein E, Dyslipidemias | Deregulated Nutrient Sensing | The relevance of serum apolipoprotein E (apoE) levels to two hypertriglyceridemic dyslipidemias has not been clarified. | 23096223 |
| Dyslipidemias, Diabetes Mellitus, Lipodystrophy, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | Dyslipidemia, hypertension, diabetes mellitus and renal failure were the most frequent conditions; 17 pts (14%) had clinical lipodystrophy secondary to TAR. | 23096476 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | MS was classified according to International Diabetes Federation (2007) and the presence of dyslipidemia according to Back et al. | 23097084 |
| Inflammation, Observation Method - Coagulation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of physical activity with insulin resistance, subclinical inflammation, coagulation, and fibrinolytic biomarkers among population at high risk for type 2 diabetes. | 23101283 |
| Inflammation, Observation Method - Coagulation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | TO investigate the association of physical activity with insulin resistance and biomarkers of inflammation, coagulation, and fibrinolysis in a population at high risk for type 2 diabetes. | 23101283 |
| Inflammation | Deregulated Nutrient Sensing | Physical activity was independently associated with insulin resistance and biomarkers of inflammation, whereas only a tendency towards decreased concentrations of coagulation and fibrinolytic biomarkers with increasing physical activity was observed. | 23101283 |
| Triglycerides, ETV3 wt Allele | Deregulated Nutrient Sensing | Our results suggest that insulin resistance may be independently associated with MetS, large waist circumference, high triglycerides, and low HDL-C only among girls. | 23107107 |
| Weight decreased | Deregulated Nutrient Sensing | Insulin resistance predicts the effectiveness of different glycemic index diets on weight loss in non-obese women. | 23108147 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, hypertension, smoking, diabetes mellitus, and dyslipidemia were more prevalent among patients with significant CAD (P<0.05). | 23108183 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There were high incidence rates of hypertension (20%), diabetes mellitus (11%), dyslipidemia (38%), and smoking (34%). | 23108720 |
| Cerebrovascular | Deregulated Nutrient Sensing | Association of hematological parameters with insulin resistance, insulin sensitivity, and asymptomatic cerebrovascular damage: the J-SHIP and Toon Health Study. | 23109550 |
| With intensity | Deregulated Nutrient Sensing | Conversely, low hematocrit was a significant risk factor for periventricular hyperintensity independent of insulin resistance. | 23109550 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | Low IGF-I levels have been associated with obesity, insulin resistance, hepatic steatosis, and were shown to predict cardiovascular mortality. | 23111188 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The five most frequent conditions in men (median age 47 years) were dyslipidaemia (81.2%), hypertension (54.4%), low HDLc (41.1%), elevated triglycerides (32.3%) and elevated non-HDLc (26.8%). | 23111762 |
| CNTNAP1 protein, human, Hypertension, CTCAE, IFNG wt Allele, Dyslipidemias | Deregulated Nutrient Sensing | Manidipine seems to ameliorate the possible statin-associated increase in insulin resistance as compared with olmesartan in patients with IFG, hypertension, and mixed dyslipidemia. | 23113965 |
| Hyperinsulinism, Ischemic stroke | Deregulated Nutrient Sensing | Hyperinsulinaemia and insulin resistance are involved in the pathogenesis of ischaemic stroke. | 23115066 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Having a diagnosis of diabetes or dyslipidemia was significantly associated with greater monitoring rates. | 23117285 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this study was to determine the association of exposure to LAN in an uncontrolled home setting with melatonin secretion, obesity, dyslipidemia, and diabetes. | 23118419 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Furthermore, LAN exposure is associated with higher odds ratios (ORs) for obesity (body mass index: OR, 1.89; P = 0.02; abdominal: OR, 1.62; P = 0.04) and dyslipidemia (OR, 1.72; P = 0.02) independent of demographic and socioeconomic parameters. | 23118419 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Moreover, LAN exposure is associated with higher ORs for obesity and dyslipidemia independent of demographic and socioeconomic parameters. | 23118419 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Elevated serum level of retinol-binding protein 4 (RBP4) has been associated with obesity-related co-morbidities including insulin resistance, dyslipidemia and hypertension. | 23119072 |
| Diabetic Nephropathy, Diabetes Mellitus, Non-Insulin-Dependent, Osteoporosis | Deregulated Nutrient Sensing | The relationship between insulin resistance and osteoporosis in elderly male type 2 diabetes mellitus and diabetic nephropathy. | 23122575 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Paediatric type III dyslipidaemia: a case of vanishing hyperlipidaemia. | 23125303 |
| Hepatitis C | Deregulated Nutrient Sensing | [Insulin resistance disturbances in patients with HCV infection]. | 23131982 |
| Hepatitis C | Deregulated Nutrient Sensing | The aim of investigation was to study the impact of insulin resistance in patients with HCV infection. | 23131982 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population. | 23133645 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | 1542 samples (692 T2D patients and 850 controls) were sequenced for the 1.46 kb region upstream the translation start site of the SIRT1 gene. | 23133645 |
| Choroidal Neovascularization | Deregulated Nutrient Sensing | The purpose of this study was to evaluate the potential role of SIRT1 in the pathogenesis of choroidal neovascularization in age-related macular degeneration. | 23135526 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Neck circumference was found to be a powerful indicator of atherogenic dyslipidaemia above and beyond central obesity indicators. | 23135790 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | The proportion of donors with obesity increased from 8% to 26% and with glucose intolerance from 9% to 25%. | 23137211 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The prevalence of Dyslipidemia, overweight and obesity were 88%, 48.7% and 18.7% respectively. | 23139960 |
| Hyperglycemia, Dyslipidemias, diabetic, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, hyperglycemia, dyslipidemia and obesity are prevalent among our diabetic patients. | 23139960 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | [Serum changes of adiponectin, insulin resistance and their correlation in endometrial cancer patients]. | 23141290 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | To explore changes of serum adiponectin and insulin resistance in patients with endometrial cancer and to evaluate the clinical significance and correlation. | 23141290 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | Adiponectin reducing and insulin resistance in reproductive age patients may be the independent factors to promote endometrial cancers. | 23141290 |
| Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | In multivariate analysis, NAFLD was independently associated with being Mexican-American (including Hispanic or other ethnicity), larger waist circumference (cm), type-2 diabetes, insulin resistance and hypertension. | 23143735 |
| Microalbuminuria, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | High urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria. | 23144053 |
| Cardiac complication, hepcidin | Deregulated Nutrient Sensing | Due to recently discovered pleiotropic effects of hepcidin, this may worsen insulin resistance and contribute to the cardiovascular complications of MetS. | 23144745 |
| Obesity | Deregulated Nutrient Sensing | Serum liver fatty acid binding protein levels correlate positively with obesity and insulin resistance in Chinese young adults. | 23144966 |
| Obesity | Deregulated Nutrient Sensing | Serum FABP1 correlates positively with obesity and insulin resistance in Chinese young adults. | 23144966 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | A significant correlation was observed between resting pulse rate and TC (r = 0.102, P = 0.001), TG (r = 0.182, P = 0.001), and dyslipidemia (r = 0.037, P = 0.008). | 23145157 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | In the multivariate models, the adjusted odds ratios for hypercholesterolemia (from 1.07 to 1.15), hypertriglyceridemia (1.11 to 1.16), low HDL hypercholesterolemia (1.03 to 1.06), high LDL hypercholesterolemia (0.92 to 1.14), and dyslipidemia (1.04 to 1.07) were positively increased across quartiles of resting pulse rate (P for trend <0.05). | 23145157 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The ROC curve indicated that resting pulse rate had low sensitivity (78.95%, 74.18%, 51.54%, 44.39%, and 54.22%), specificity (55.88%, 59.46%, 57.27%, 65.02%, and 60.56%), and the area under ROC curve (0.70, 0.69, 0.54, 0.56, and 0.58) for identifying the risk of hypercholesterolemia, hypertriglyceridemia, low HDL hypercholesterolemia, high LDL hypercholesterolemia, and dyslipidemia, respectively. | 23145157 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Frequent eye examination should be undertaken in patients having underlying risk factors like diabetes, hypertension or dyslipidemia undergoing interferon therapy. | 23146860 |
| Fatty degeneration | Deregulated Nutrient Sensing | Patients with steatosis had decreased phosphorylation of the insulin kinase AKT1, mediating insulin receptor signaling, and the transcription factor FOXO1, which was therefore more active mediating insulin resistance at transcriptional level. | 23147115 |
| Liver damage, Fatty degeneration, Dyslipidemias | Deregulated Nutrient Sensing | IRS2 expression was correlated with the severity of steatosis, dyslipidemia and liver damage. | 23147115 |
| Obesity, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Physical inactivity, arterial hypertension, dyslipidemia, obesity, and diabetes mellitus increased with age. | 23150649 |
| Glucose Intolerance (disease), Obesity, Abdominal | Deregulated Nutrient Sensing | The overall prevalence of glucose intolerance was 3.7% but was higher in girls compared with boys (4.2% vs. 3.2%, P<0.001) and increased to 12.7% in girls with abdominal obesity. | 23151017 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Educational inequalities in the distribution of CVRF were larger in women than in men for alcohol consumption, obesity, hypertension and dyslipidemia (p<0.05). | 23152909 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Decreased circulating endothelial progenitor cells (EPCs), increased asymmetric dimethyl-arginine (ADMA) levels, traditional cardiovascular risk factors and insulin resistance have all been associated with increased arterial stiffness. | 23153108 |
| ERBB3 wt Allele, THM gene, Non-Small Cell Lung Carcinoma, Acute Erythroblastic Leukemia | Deregulated Nutrient Sensing | Pathway activation mapping of NSCLC revealed distinct subgroups composed of epidermal growth factor receptor (ERBB1), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ERBB3), v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4), v-akt murine thymoma viral oncogene homolog 1- mammalian target of rapamycin (AKT-mTOR), protein kinase, AMP-activated, alpha 2 catalytic subunit (AMPK), and autophagy-related signaling, along with transforming growth factor-beta-signaling protein 1 (SMAD), insulin-line growth factor receptor (IGFR), rearranged during transfection proto-oncogene (RET), and activated CDC42-associated kinase (ACK) activation. | 23154546 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | On the 75 g OGTT, 50 mg Losartan with 12.5 mg HCTZ combinations did not worsen glucose tolerance; moreover, they improved BP, insulin resistance and sensitivity in non-DM Japanese patients with essential hypertension uncontrolled with ARBs alone. | 23154622 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Information about subjects' history of dyslipidemia, treatment and control were collected by face-to-face interview; and each subject's fasting venous blood was drawn in the morning before having food, to test total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C). | 23157860 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | [The association of insulin resistance, blood pressure variability and severity of acute coronary syndrome]. | 23158858 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | ROC curve analysis in diabetes, hypertension, dyslipidemia and multivariate logistic regression analysis were also conducted. | 23158916 |
| Microalbuminuria, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Eight patients (45%) had hypertension, while dyslipidemia and microalbuminuria was present in 7 patients (39%) each. | 23158974 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). | 23159207 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Further adjustment for diabetes mellitus or insulin resistance, protection against which has been proposed to mediate the beneficial relationships of adiponectin with outcome, attenuated the association in the lower range. | 23159554 |
| Obesity | Deregulated Nutrient Sensing | Increased serum osteocalcin levels were accompanied by a decreasing trend in all anthropometric indices of obesity, systolic blood pressure, blood glucose, insulin resistance index, triglycerides, free fatty acid, and C-reactive protein levels (all P < 0.05). | 23162093 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is a chronic and complex disease that is characterized by impaired insulin resistance and dysregulated immune response. | 23163570 |
| Dyslipidemias, ETV3 wt Allele | Deregulated Nutrient Sensing | Among MetS determinants, only dyslipidaemia (increased serum triglycerides and reduced serum high-density lipoprotein) was associated with an increased risk of having a prostatic volume >60 cm(3) (hazard ratio (HR) = 3.268, P < 0.001). | 23165431 |
| Steatohepatitis, Dyslipidemias, Overweight, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To verify potential risk factors associated with hepatic steatosis, such as: alcohol consumption, overweight, dyslipidemia, hypertension, and type 2 diabetes mellitus. | 23165584 |
| Dyslipidemias | Deregulated Nutrient Sensing | Elevated levels of intact parathyroid hormone (iPTH) may play an important role in the pathogenesis of the dyslipidemia in hemodialysis (HD) patients, but the underlying mechanisms are not clearly defined. | 23168847 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest that iPTH most probably does not play a significant role in the dyslipidemia of renal failure. | 23168847 |
| Adrenal incidentaloma, Cushing Syndrome, Dyslipidemias, Saint Helena Islands, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Spinal Fractures | Deregulated Nutrient Sensing | The possible different prevalence of arterial hypertension (AH), type 2 diabetes mellitus (T2DM), dyslipidaemia (DL) and vertebral fractures (FX) between patients with bilateral and unilateral adrenal incidentalomas (BAI and UAI, respectively) with and without subclinical hypercortisolism (SH) is unknown. | 23169694 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | The combination of colesevelam with rosuvastatin 5 mg/day may be associated with favorable effects on markers of insulin resistance compared with rosuvastatin 10 mg/day in patients with hypercholesterolemia and IFG. | 23170931 |
| Inflammation, Corneal Endothelial Cell Loss | Deregulated Nutrient Sensing | The aim of our study was to determine whether plasma levels of oxLDL/b2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/b2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. | 23171597 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | In summary, oxLDL/b2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study. | 23171597 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In addition to its close association with Type 2 diabetes, which reduces life expectancy in older people, age-related insulin resistance is implicated in pathogenesis of several highly prevalent disorders for which ageing is a major risk factor. | 23173973 |
| Obesity | Deregulated Nutrient Sensing | The rapidly rising number of older people, coupled with a high prevalence of insulin resistance resulting from obesity and sedentary lifestyles, presents unprecedented public health and societal challenges. | 23173973 |
| Inflammation | Deregulated Nutrient Sensing | Vitamin D deficiency is associated with risk for a first cardiovascular event in the general population, possibly because of inflammation, insulin resistance, and neurohumoral activation. | 23174181 |
| myocardial injury | Deregulated Nutrient Sensing | Impact of insulin resistance on post-procedural myocardial injury and clinical outcomes in patients who underwent elective coronary interventions with drug-eluting stents. | 23174640 |
| myocardial injury | Deregulated Nutrient Sensing | These results indicated the impact of insulin resistance on post-procedural myocardial injury and clinical outcome after elective PCI with drug-eluting stent deployment. | 23174640 |
| macroangiopathy, Low-Density Lipoproteins, Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | CD36 may play an important role in removal of oxidized LDLs from plasma, protein glycation, the pathogenesis of insulin resistance, type 2 diabetes, and diabetic micro- and macroangiopathy. | 23175350 |
| Hyperglycemia, Dyslipidemias, Inflammation, Prediabetes syndrome | Deregulated Nutrient Sensing | Pioglitazone slowed progression of CIMT, independent of improvement in hyperglycemia, insulin resistance, dyslipidemia, and systemic inflammation in prediabetes. | 23175674 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Although impaired synthesis and/or bioavailability of nitric oxide are considered to contribute to insulin resistance and the progression of liver disease in nonalcoholic fatty liver disease, role of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, has not been examined. | 23179302 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Endothelial dysfunction (flow-mediated dilation, FMD), hsCRP and insulin resistance were determined. | 23180042 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | We also looked at how NLR and its individual components change across CKD stages and whether NLR is related to CRP, insulin resistance and endothelial dysfunction. | 23180042 |
| Weight Gain, Non-alcoholic Fatty Liver Disease, Epilepsy, Fatty Liver Disease | Deregulated Nutrient Sensing | Valproic acid (VPA), as one of the most widely prescribed antiepileptic drugs (AED) for many types of epilepsy in adults and children, is associated with weight gain, alteration of adipocytokine homeostasis, insulin resistance and Non-Alcoholic Fatty Liver Disease (NAFLD). | 23182413 |
| Non-alcoholic Fatty Liver Disease, Obesity, Visceral, Diabetes Mellitus | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4) and Glucagon-like peptide-1 (GLP-1) are considered as important new targets in modern type 2 diabetes mellitus therapy linked to insulin resistance, NAFLD and visceral obesity acting via peripheral or central mechanisms. | 23182413 |
| Depressive disorder | Deregulated Nutrient Sensing | Plasma fatty acid profile in depressive disorder resembles insulin resistance state. | 23183516 |
| Depressive disorder | Deregulated Nutrient Sensing | The aim of the study was to investigate the composition of FA in plasma cholesterol esters (CE) and phosphatidylcholine (PC) as well as indices of insulin resistance and oxidative stress in the patients with depressive disorder. | 23183516 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Esterified FA composition of depressive patients revealed changes, similar to those, usually observed in insulin resistance. | 23183516 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia contributes substantially to the residual cardiovascular risk. | 23183517 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Peripheral insulin resistance in type 1 diabetes may be related to a paradoxical postprandial glucagon increase. | 23186950 |
| Hyperlipidemia, Cardiomyopathies, Liver Dysfunction, Obesity, Hypogonadism, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Alstrom syndrome is a rare disorder typified by early childhood obesity, neurosensory deficits, cardiomyopathy, progressive renal and hepatic dysfunction, and endocrinological features such as severe insulin resistance, type 2 diabetes, hyperlipidemia, and hypogonadism. | 23188138 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Multivariate logistic regression analysis identified a medical history of dyslipidemia as an independent predictor for chronic kidney disease manifested postoperatively. | 23190329 |
| Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | Our results show that high-flux dialyzers improved dyslipidemia and endothelial dysfunction in hemodialysis patients. | 23190521 |
| Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | The APOM polymorphism as a novel risk factor for dyslipidaemia in rheumatoid arthritis: a possible shared link between disease susceptibility and dyslipidaemia. | 23190940 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | We investigated the possible association between an APOM polymorphism and dyslipidaemia in Korean RA patients. | 23190940 |
| Dyslipidemias, Disease | Deregulated Nutrient Sensing | Subgroup analyses according to disease activity showed that the association between APOM genotype and HDL cholesterol levels was still significant in all subgroups, indicating that this APOM polymorphism may increase the dyslipidaemia risk, independently of RA disease activity. | 23190940 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | These data support that the APOM C-1065A polymorphism is associated with increased risk for developing RA and dyslipidaemia in RA patients. | 23190940 |
| Refractory anemias, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | These findings suggest that a specific genetic factor for RA could be linked to dyslipidaemia and this could increase the risk of atherosclerosis in RA patients. | 23190940 |
| Sarcopenia, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance (IR), which is highly prevalent in patients receiving CHD, has been proposed to play a critical role in the development of sarcopenia. | 23194840 |
| Sarcopenia, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance represents a potential mechanism for sarcopenia commonly observed in patients receiving CHD. | 23194840 |
| ETV3 wt Allele, Dyslipidemias, Ventricular dilatation (disorder), Hypertension, CTCAE | Deregulated Nutrient Sensing | The MetS group (n = 229) had higher incidence of hypertension, dyslipidemia, and ventricular dilatation than the non-MetS group (n = 256). | 23196975 |
| Anxiety, CTCAE 3.0, Obesity, Abdominal, Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity. | 23197842 |
| Anxiety, CTCAE 3.0, Obesity, Abdominal, Depression, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Previous research indicates that patients with severe symptoms of depression or anxiety are prone toward the development of dyslipidemia and abdominal obesity. | 23197842 |
| Dyslipidemias, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Therefore, such people are at elongated and increasing risk for dyslipidemia and obesity, predisposing them to cardiovascular disease. | 23197842 |
| Hypertension, CTCAE, diabetic, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We studied 216 patients who attended our diabetic center with diagnoses of diabetes, hypertension and/or dyslipidemia. | 23198531 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The important role of raised serum gamma-glutamyl transferase (GGT) for predicting diabetes mellitus and insulin resistance is clear; however relationship between increased level of GGT and impaired glucose tolerance (IGT) is now hypothesized. | 23199536 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Ventricular hypertrophy | Deregulated Nutrient Sensing | The most common CV risk factors included left ventricular hypertrophy (72% of patients), abdominal obesity (54%), dyslipidemia (48%), family history of early CV events (33%), smoking (24%), and type 2 diabetes (21%). | 23203238 |
| urinary, Diabetes Mellitus | Deregulated Nutrient Sensing | Urinary iodine is associated with insulin resistance in subjects with diabetes mellitus type 2. | 23203253 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | C-peptide is a proinsulin cleavage product released from the pancreas in amounts equimolar to insulin, and elevated levels of C-peptide have been found in patients with insulin resistance and early type 2 diabetes mellitus. | 23204248 |
| Apolipoproteins B, nialamide | Deregulated Nutrient Sensing | Subjects with EIH presented higher waist circumference (WC) (P<0.01), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB) levels as well as insulin resistance (all P<0.05). | 23205504 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | The increased S100A9 reported for obesity and insulin resistance may be envisioned as a compensatory mechanism for inflammation. | 23207880 |
| Inflammation, Kidney Failure, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Patients with chronic kidney disease (CKD) are likely to have low levels of 25(OH)D, and recent observations have linked suboptimal vitamin D status with adverse cardiovascular outcomes, inflammation, insulin resistance, and the rate of progression of renal insufficiency. | 23209039 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Increases in dyslipidemia and abdominal obesity contributed to the increased prevalence in Korea, whereas in the United States, decreases in low high-density lipoprotein cholesterolemia and high blood pressure contributed to a decreased prevalence. | 23209102 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is an underlying cause of metabolic changes associated with cardiovascular diseases. | 23212335 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | When patients with diabetes mellitus were compared to patients without insulin resistance, significantly lower levels of GRa mRNA were observed in epicardial fat. | 23212335 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Increased toll-like receptor 2 expression in peptidoglycan-treated blood monocytes is associated with insulin resistance in patients with nondiabetic rheumatoid arthritis. | 23213270 |
| Refractory anemias | Deregulated Nutrient Sensing | The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. | 23213270 |
| Refractory anemias | Deregulated Nutrient Sensing | Accordingly, TLR-2 receptor and its related inflammatory cytokines could be potential therapeutic targets in managing insulin resistance in RA patients. | 23213270 |
| Neoplasms | Deregulated Nutrient Sensing | Novel (nua) kinase family 1 (NUAK1) is a member of the human adenosine monophosphate (AMP)-activated protein kinase family that has been identified as a key tumor cell survival factor. | 23215946 |
| Demographics Domain, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). | 23216712 |
| Cockayne Syndrome | Deregulated Nutrient Sensing | Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. | 23217256 |
| Progeria | Deregulated Nutrient Sensing | The link between conserved SIRT1 longevity pathway and progeria suggests a stem cell-based and SIRT1 pathway-dependent therapeutic strategy for progeria. | 23217256 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia and hypertension are the major risk factors contributing to cardiovascular disease (CVD). | 23217598 |
| Dyslipidemias, Complications of Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Based on these data the annual prevalences of dyslipidemia and hypertension were calculated and patients were stratified by age, gender, and diabetic complications. | 23217598 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with diabetes, the prevalence of dyslipidemia increased with age, with the highest rate recorded in adults (inclusive of both genders) between 40 and 65 years of age (p for trend <0.001). | 23217598 |
| Disorder of eye, Dyslipidemias, Kidney Diseases, diabetic | Deregulated Nutrient Sensing | The prevalence of dyslipidemia increased in diabetic patients with eye diseases and in men with nephropathies, but decreased in women with nephropathies during the study period. | 23217598 |
| Cerebrovascular Disorders, Dyslipidemias, Cerebrovascular accident, Cardiac complication, Peripheral Vascular Diseases | Deregulated Nutrient Sensing | In contrast, the prevalence of dyslipidemia decreased in patients with macrovascular complications, including CVD and cerebrovascular disease (cerebrovascular accident), but increased in those patients with PVD (p for all trends <0.05). | 23217598 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Cerebrovascular accident, Hypertension, CTCAE | Deregulated Nutrient Sensing | Although progressively increased prevalence of dyslipidemia and hypertension was observed in patients with diabetes in Taiwan, there was a decrease in the prevalence of stroke and CVD in the past 10 years. | 23217598 |
| Peripheral Vascular Diseases, Vascular Diseases, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Among those with macrovascular diseases, except PVD, there was a trend of decreased prevalence of hypertension and dyslipidemia during the study period. | 23217598 |
| Dyslipidemias, Microvascular Angina, Hypertension, CTCAE, Disorder of eye | Deregulated Nutrient Sensing | In patients with microvascular diseases, prevalence of hypertension and dyslipidemia in patients with eye diseases increased in the past 10 years. | 23217598 |
| Liver Cirrhosis, Fatty Liver Disease | Deregulated Nutrient Sensing | Increases in body mass index and fluctuations in transaminase levels, as well as the evaluation of homeostatic model assessment-insulin resistance, ferritin, and hyaluronic acid in F3 stage NASH patients may prove useful in identifying individuals at risk of progression to cirrhosis. | 23221052 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | BMI, prevalence of central obesity, homeostatic model assessment index of insulin resistance, plasma triglycerides, fibrinogen, and CRP increased progressively across categories of glucose intolerance (P < 0.0001), with the IFG+IGT group having higher values than those with isolated IFG (0.05 < P < 0.0001). | 23223343 |
| Atherosclerosis | Deregulated Nutrient Sensing | However, the direct role of SIRT1 in atherosclerosis and how SIRT1 in VSMCs might regulate atherosclerosis are unknown. | 23224247 |
| atherosclerotic | Deregulated Nutrient Sensing | SIRT1 expression was reduced in human atherosclerotic plaques and VSMCs both derived from plaques and undergoing replicative senescence. | 23224247 |
| Low-Density Lipoproteins | Deregulated Nutrient Sensing | VSMCs from mice expressing inactive truncated SIRT1 (Dex4) showed increased oxidized low-density lipoprotein-induced DNA damage and senescence. | 23224247 |
| Atherosclerosis | Deregulated Nutrient Sensing | ApoE(-/-) mice expressing SIRT1(Dex4) only in smooth muscle cells demonstrated increased DNA damage response activation and apoptosis, increased atherosclerosis, reduced relative fibrous cap thickness, and medial degeneration. | 23224247 |
| Atherosclerosis | Deregulated Nutrient Sensing | SIRT1 is reduced in human atherosclerosis and is a critical regulator of the DNA damage response and survival in VSMCs. | 23224247 |
| Medial degeneration, Atherosclerosis | Deregulated Nutrient Sensing | VSMC SIRT1 protects against DNA damage, medial degeneration, and atherosclerosis. | 23224247 |
| Atherosclerosis | Deregulated Nutrient Sensing | Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. | 23224247 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In both genders, such overestimation was predicted by dyslipidemia, a lower waist circumference, a higher level of perceived fitness, and no exercise intention; also (among men) by a higher age and a family history of diabetes, and (among women) by a lower occupational status, and a lower BMI. | 23224617 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | In addition, there were gender and aging differences in % smoking, % HT, BMI and eGFR, whereas no differences were observed in % DM, % dyslipidemia or % HU. | 23224925 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, pre-diabetes and insulin resistance screening in Native American children and youth. | 23229738 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Early identification of pre-diabetes and insulin resistance (IR) provides an important window of opportunity for diabetes prevention. | 23229738 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Glycemia, insulin resistance, insulin secretion, and risk of depressive symptoms in middle age. | 23230097 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Vitamin D deficiency has been implicated in decreased insulin secretion and increased insulin resistance, hallmarks of type 2 diabetes mellitus. | 23232064 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Use of a performance measure that credits appropriate clinical action indicates that almost 85% of diabetic veterans 50 to 75 years of age are receiving appropriate dyslipidemia management. | 23233749 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | This study demonstrates that seasonal variation in MetS prevalence is associated with mildly to moderately increased insulin resistance in middle-aged Japanese men. | 23235713 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | As the case detection rate of arterial hypertension increases daily in rural Nigeria, screening for its associated abdominal obesity and dyslipidemia is an important healthcare challenge. | 23238199 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Of great concern in rural Nigeria is that most geriatric hypertensives with abdominal obesity and dyslipidemia are not routinely diagnosed and therefore do not receive appropriate management. | 23238199 |
| Dyslipidemias | Deregulated Nutrient Sensing | Fifty-four (44.3%) out of 122 patients had at least one dyslipidemia with the most frequent being low high-density lipoprotein cholesterol (HDL-C, 38.5%). | 23238199 |
| Obesity, Abdominal, Antihypertensive Agents, Dyslipidemias | Deregulated Nutrient Sensing | This study has shown that abdominal adiposity and dyslipidemia exist among geriatric hypertensives in the study area with abdominal obesity being the most common abdominal adiposity and low HDL-C being the most frequent lipid abnormality. | 23238199 |
| Dyslipidemias, Obesity, Abdominal, Antihypertensive Agents | Deregulated Nutrient Sensing | This study therefore urges the necessity to consider abdominal obesity and dyslipidemia in geriatric hypertensives in rural Nigeria alongside the complex of other cardiovascular risk factors. | 23238199 |
| Muscle (organ) | Deregulated Nutrient Sensing | Insulin signal transduction was competent up to p-Akt activation; however, p-adenosine monophosphate-activated protein kinase (p-AMPK) was not detectable in CIM muscle. | 23239154 |
| Atrophic | Deregulated Nutrient Sensing | Electrical muscle stimulation increased p-AMPK, repositioned GLUT4, locally improved glucose metabolism, and prevented type-2 fiber atrophy. | 23239154 |
| Muscle Contraction, Failure (biologic function) | Deregulated Nutrient Sensing | Evoked muscle contraction may prevent muscle-specific AMPK failure, restore GLUT4 disposition, and diminish protein breakdown. | 23239154 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Low-density lipoprotein cholesterol (LDL-C) remains the primary target of therapy in most strategies of dyslipidaemia management focused on cardiovascular disease prevention. | 23241052 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes and dyslipidaemia increased with age and body mass index. | 23241053 |
| Presenile dementia, "Alzheimers Disease", Impaired cognition, Data types - Address | Deregulated Nutrient Sensing | Insulin resistance increases the risk of cognitive impairment and dementia, but higher insulin levels may be cognitively protective after a diagnosis of Alzheimer's disease (AD). | 23241558 |
| Inflammation, Pancreatic carcinoma | Deregulated Nutrient Sensing | Although development of pancreatic cancer is associated with states of insulin resistance and chronic inflammation, the mechanistic basis of the associations is poorly understood. | 23243202 |
| Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Plasma adiponectin was inversely associated with pancreatic cancer risk, which was consistent across the five prospective cohorts (P (heterogeneity) = .49) and independent of other markers of insulin resistance (eg, diabetes, body mass index, physical activity, plasma C-peptide). | 23243202 |
| Inflammation, SLC5A8 wt Allele | Deregulated Nutrient Sensing | The numbers of attacks and of individuals with attacks were examined in conjunction with endothelial function, oxidative stress, inflammation, and insulin resistance before and after 3 successive days of AIT. | 23249633 |
| Inflammation, SLC5A8 wt Allele, Angina Pectoris, Variant | Deregulated Nutrient Sensing | AIT in the afternoon suppressed the attacks in conjunction with improvement in endothelial function, oxidative stress, inflammation, and insulin resistance in patients with coronary spastic angina. | 23249633 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Among individuals without type 2 diabetes, similar effect modification was observed by obesity and insulin resistance. | 23250801 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The association of fetuin-A with risk of CVD differs among elderly individuals with and without insulin resistance or type 2 diabetes. | 23250801 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is one of the important modifiable risk factors for cardiovascular disease. | 23251338 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | There is recent interest surrounding the use of the triglyceride-to-HDL cholesterol ratio as a surrogate marker of insulin resistance in clinical practice, as it may identify people at high risk of developing diabetes or its complications. | 23251403 |
| Dyslipidemias, Chronic Obstructive Airway Disease, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | The patient was affected by arterial hypertension, dyslipidaemia, severe chronic obstructive pulmonary disease, and recurrent atrial fibrillation. | 23253549 |
| Coronary Artery Disease, diabetic | Deregulated Nutrient Sensing | We hypothesised, that perioperative use of N(2)-L-alanyl-L-glutamine confers cardioprotection and improves insulin resistance in diabetic patients with coronary artery disease operated under cardiopulmonary bypass. | 23253886 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Effect of bezafibrate on office, home and ambulatory blood pressure in hypertensive patients with dyslipidemia. | 23254592 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | We investigated the effects of bezafibrate on office, home and ambulatory BP in hypertensive patients with dyslipidemia. | 23254592 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, bezafibrate improved lipid metabolism and insulin sensitivity but did not affect office, home or ambulatory BP in hypertensive patients with dyslipidemia. | 23254592 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | A decreased risk was also found with high TG levels which may depend on genetic vulnerability to dyslipidemia related to APOA5. | 23254630 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Here we discuss how these p53-mTORC1 interactions might play a role in the suppression of cancer and perhaps the development of cellular senescence and organismal aging. | 23255104 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. | 23255128 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | While SIRT1 exerts beneficial effects in protecting against age-related diseases, the role of SIRT1 in cancer has been controversial. | 23255128 |
| Neoplasms | Deregulated Nutrient Sensing | SIRT1 promotes cell survival by deacetylating, and thereby negatively regulating the activity of important tumor suppressors such as p53. | 23255128 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | In contrast, it has been shown that SIRT1 deficiency leads to increased genomic instability and tumorigenesis, and that overexpression of SIRT1 attenuates cancer formation in mice, suggesting it may also act as a tumor suppressor. | 23255128 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | In order to gain insight into the role of SIRT1 in cancer, we performed a comprehensive resequencing analysis of the SIRT1 gene in 41 tumor cell lines and found an unusually excessive homozygosity, which was confirmed to be allelic loss by microsatellite analysis. | 23255128 |
| Neoplasms | Deregulated Nutrient Sensing | We conclude that allelic loss or mutations in the SIRT1 gene occur prevalently during tumorigenesis, supporting the assertion that SIRT1 may serve as a tumor suppressor. | 23255128 |
| Damage, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage. | 23255852 |
| ARCN1 gene | Deregulated Nutrient Sensing | Unexpectedly, calcineurin expression was higher, while phospho-AMPK was lower, in COPD patients with fibre shift compared to COPD patients without fibre shift. | 23258787 |
| ARCN1 gene | Deregulated Nutrient Sensing | Reduced phospho-AMPK may contribute to reduced quadriceps oxidative capacity and endurance in COPD. | 23258787 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of hypertension, Type 2 diabetes and dyslipidaemia was 45.6, 13.3 and 41.7%, respectively. | 23258806 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Haiti, Hypertensive (finding) | Deregulated Nutrient Sensing | The prevalence of cardiovascular risk factors in hypertensive women (HT) with respect to non-hypertensive women (NHT) was as follows: obesity 44.7 versus 18.9%, dyslipidaemia 48.8 versus 35.8% and Type 2 diabetes 21.8 versus 6.1%. | 23258806 |
| Hyperparathyroidism, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and secondary hyperparathyroidism were not accounted for in the analysis. | 23260275 |
| Inflammation, Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | This study identifies possible mediators of the effect of SEAD on myocardial infarction, because SEAD is associated with a lower concentration of markers of inflammation and with reduced triglycerides, insulin, insulin resistance, and systolic blood pressure. | 23261168 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Specific constellations of lipoprotein particle features, reflected as differences in mean lipoprotein particle diameters, are associated with risk of insulin resistance (IR) and cardiovascular disease (CVD). | 23263444 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | People infected with HIV have a higher risk for developing insulin resistance, diabetes, and cardiovascular disease than the general population. | 23264399 |
| Myocardium | Deregulated Nutrient Sensing | Whether this may be attributed to the insulin resistance of cardiac muscle has to be further investigated. | 23264539 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Risk reductions for cardiovascular disease with pravastatin treatment by dyslipidemia phenotype: a post hoc analysis of the MEGA Study. | 23265677 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Significant risk reductions were observed for CHD by 38% (p=0.04) and CVD by 31% (p=0.02) in type IIa dyslipidemia but not in phenotype IIb. | 23265677 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Pravastatin therapy provided significant risk reductions for CHD and CVD in patients with phenotype IIa dyslipidemia, but not in those with phenotype IIb dyslipidemia. | 23265677 |
| Obesity | Deregulated Nutrient Sensing | Predictors of insulin resistance in patients with obesity: a pilot study. | 23267236 |
| diabetic | Deregulated Nutrient Sensing | The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. | 23269546 |
| diabetic | Deregulated Nutrient Sensing | Our findings suggest that p53 codon 72 (Arg72Pro) polymorphism influences insulin resistance in type 2 diabetic patients independently of body mass. | 23269546 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Carbohydrate nutrition differs by diabetes status and is associated with dyslipidemia in Boston Puerto Rican adults without diabetes. | 23269655 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | Instead, the levels of total cholesterol (TC), TG, LDL-C, and the prevalence of dyslipidemia were significantly higher in the three Bama families as compared to the two non-Bama families (P < 0.01 for all). | 23273182 |
| Increased insulin level, Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Zinc-a2-glycoprotein is associated with insulin resistance in humans and is regulated by hyperglycemia, hyperinsulinemia, or liraglutide administration: cross-sectional and interventional studies in normal subjects, insulin-resistant subjects, and subjects with newly diagnosed diabetes. | 23275352 |
| Diabetes Mellitus, Non-Insulin-Dependent, Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Serum ZAG (determined with ELISA) was compared with various parameters related to insulin resistance in subjects with normal glucose tolerance, impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM), and in women with or without polycystic ovary syndrome (PCOS). | 23275352 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. | 23275372 |
| Infertility, Dyslipidemias | Deregulated Nutrient Sensing | Relationship between dyslipidaemia and semen quality and serum sex hormone levels: an infertility study of 167 Japanese patients. | 23278423 |
| Cortical malformations | Deregulated Nutrient Sensing | Transfection of E6 into fetal mouse brains caused a focal cortical malformation in association with enhanced mTORC1 signaling. | 23280839 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | The crude HR of developing ACS for the DM group compared to the non-DM group was 1.333 (95% confidence interval [95% CI] 1.236-1.439, P < 0.0001), whereas the adjusted HR was 1.321 (95% CI 1.224-1.425, P < 0.0001) after adjustment for age, sex, and dyslipidemia. | 23281342 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Even though previous studies have demonstrated that thyroid hormone replacement therapy (THRT) improves cardiac function and dyslipidemia in patients with SCH, it remains unclear as to whether THRT can improve renal function in CKD patients with SCH. | 23281965 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Adiponectin has antidiabetic properties, and patients with obesity, diabetes, and insulin resistance have low plasma adiponectin levels. | 23283133 |
| Kidney Failure, Chronic, Kidney Diseases | Deregulated Nutrient Sensing | However, although kidney disease is associated with insulin resistance, adiponectin is elevated in end-stage renal disease. | 23283133 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | We studied the characteristics of insulin resistance in 19 normotensive and 25 hypertensive subjects who underwent an acute protocol for determination of salt-sensitivity of blood pressure. | 23283360 |
| diabetic | Deregulated Nutrient Sensing | Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation. | 23283553 |
| diabetic | Deregulated Nutrient Sensing | Ex vivo SIRT1 activation restored EOC chemokine secretion and increased the in vitro and in vivo angiogenic activity of EOC conditioned medium derived from diabetic animals to levels similar to that derived from control animals. | 23283553 |
| physiopathological | Deregulated Nutrient Sensing | These findings suggest a pivotal role for SIRT1 in diabetes-induced EOC dysfunction and that its pharmacologic activation may provide a new strategy for the restoration of EOC-mediated repair mechanisms. | 23283553 |
| Sleep Apnea Syndromes, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Sleep apnoea syndrome and 10-year cardiovascular risk in females with type 2 diabetes: relationship with insulin secretion and insulin resistance. | 23283827 |
| Inflammation, Sleep Apnea Syndromes, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | Sleep apnoea, a frequent comorbidity of T2DM women, is associated with central fat, atherogenic dyslipidaemia, inflammation, worsening b-cell function, poorer glycaemic control and coronary artery disease risk. | 23283827 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Model 2 showed more randomly distributed residuals in patients with diabetes, atherogenic dyslipidemia, and those taking lipid-lowering agents than model 1. | 23284722 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance was diagnosed in 76% of the patients with morbid obesity (56.2% in grade II obesity and 51.4 in grade I obesity vs. 15.2% in controls). | 23285761 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The participants were married, with low education levels, family history of heart diseases, arterial hypertension, dyslipidemia, and a sedentary lifestyle. | 23288183 |
| Lipolysis | Deregulated Nutrient Sensing | Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. | 23291629 |
| Obesity | Deregulated Nutrient Sensing | TRIP-Br2-null mice are resistant to obesity and obesity-related insulin resistance. | 23291629 |
| Hyperlipidemia, Obesity | Deregulated Nutrient Sensing | These data, together with the observation that TRIP-Br2 expression is selectively elevated in visceral fat in obese humans, suggests that this transcriptional co-regulator is a new therapeutic target for counteracting the development of obesity, insulin resistance and hyperlipidemia. | 23291629 |
| Psoriasis, Obesity | Deregulated Nutrient Sensing | Psoriasis is associated with obesity accompanied by insulin resistance. | 23291856 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | CoA can effectively reduce plasma TG levels in subjects with moderate dyslipidemia and has no obvious adverse effect. | 23293333 |
| Peripheral Vascular Diseases, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Higher leucocyte levels were associated with dyslipidaemia, smoking, peripheral arterial disease, stroke severity, and lesion size. | 23295074 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | In recent years, evidence has emerged indicating that insulin resistance and diabetes mellitus type 2 are associated with inflammation of adipose tissue (AT). | 23296264 |
| Malignant neoplasm of urinary bladder, Inflammation, Obesity, Abdominal, Diabetes Mellitus | Deregulated Nutrient Sensing | We also observed a synergistic interaction between diabetes and high WHR in bladder cancer development that might be explained by increased insulin resistance and inflammation related to abdominal obesity. | 23296458 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Increasing prevalence of obesity has been associated with concomitant increases in childhood hypertension, dyslipidaemia and type 2 diabetes. | 23296459 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Due to the possible mechanism of insulin resistance which is associated with impaired insulin receptors after HSCT procedure, metformin with insulin appears to be effective in the treatment of this type of diabetes. | 23296512 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk. | 23298335 |
| Diabetes Mellitus, Chronic inflammatory disorder | Deregulated Nutrient Sensing | These results show that dietary phylloquinone intake is associated with an improvement of cytokines and other markers related to insulin resistance and diabetes, thus extending the potential protection by dietary phylloquinone on chronic inflammatory diseases. | 23298335 |
| Dyslipidemias, HIV-1 Infection Pathway, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with dyslipidemia associated with HIV-1 infection and highly active antiretroviral therapy (HAART) have elevated levels of Lp-PLA2 and CCL5/regulated on activation, normal T-cell expressed and secreted (RANTES), which may increase the risk of cardiovascular disease. | 23299761 |
| Dyslipidemias | Deregulated Nutrient Sensing | Elevated plasma Lp-PLA2 mass can be reduced by an intensive D/E program in patients with HIV/HAART-associated dyslipidemia. | 23299761 |
| Primary malignant neoplasm, Dyslipidemias, Diabetic Angiopathies, Thyroid Diseases, Chronic Obstructive Airway Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Furthermore, patients with benign thyroid disease or other cancer, living in Kao-Ping/Eastern regions, or receiving potential detection examinations might have a significantly higher risk; and male sex, hypertension, dyslipidemia, chronic obstructive pulmonary disease, vascular complications or use of statin, aspirin or non-steroidal anti-inflammatory drugs might be associated with a significantly lower risk. | 23300866 |
| Pancreatitis, Dyslipidemias, Biliary calculi | Deregulated Nutrient Sensing | Alcoholism and gallstones were associated with a large increase in the risk of acute pancreatitis (adjusted odds ratio 13.40 and 14.29, respectively, P<0.001), although dyslipidemia was associated with significant risk reduction (adjusted odds ratio 0.62, P<0.001). | 23300896 |
| Myeloid Leukemia, Chronic | Deregulated Nutrient Sensing | In healthy term infants, high dietary load with CML does not play a pathophysiological role in the induction of infant formula-associated insulin resistance. | 23301020 |
| Malignant Pleural Mesothelioma | Deregulated Nutrient Sensing | PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1. | 23301673 |
| Keloid | Deregulated Nutrient Sensing | Treatment with either KU-0063794 or KU-0068650 resulted in complete suppression of Akt, mTORC1, and mTORC2, and inhibition of keloid cell spreading, proliferation, migration, and invasive properties at a very low concentration (2.5 mmol l(-1)). | 23303455 |
| Left Ventricular Hypertrophy, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The same analysis revealed that the combination of impaired glucose level, abdominal obesity, and dyslipidemia was associated with LV hypertrophy only in women. | 23303723 |
| Diastolic dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | The combination of increased BP, fasting glucose, and dyslipidemia was independently associated with LV diastolic dysfunction only in women. | 23303723 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The magnitude of atherogenic dyslipidaemia among geriatric Nigerians with systemic hypertension in a rural hospital in Eastern Nigeria. | 23304929 |
| Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | The relevance of dyslipidaemia in the management of cardiovascular diseases, especially hypertension is an important health care challenge that is increasing worldwide. | 23304929 |
| Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | Of great concern in Nigeria is that most geriatric hypertensives with dyslipidaemia are not routinely diagnosed and therefore do not receive appropriate treatment. | 23304929 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was defined using the third report of National Cholesterol Education Panel in adult (ATP III). | 23304929 |
| Dyslipidemias | Deregulated Nutrient Sensing | Fifty-four (44.3%) out of 122 patients had at least one dyslipidaemia. | 23304929 |
| Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | This study has shown that dyslipidaemia exist among geriatric hypertensives in the study area with low HDL-C being the most frequent lipid abnormality suggesting that low HDL may be the major form of dyslipidaemia and a marker of dyslipidaemic cardiometabolic risk among them. | 23304929 |
| Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | Screening for dyslipidaemia should therefore form an important part of clinical care of geriatric hypertensives and those with dyslipidaemia should become target for lipid lowering treatment in addition to lifestyle modification. | 23304929 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | In multivariable analyses, factors independently associated with a lower risk of HAP were female gender (odds ratio [OR] 0.84), dyslipidemia (OR 0.84), and hypertension (OR 0.94). | 23305674 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Predictors of asymmetric dimethylarginine levels in patients with rheumatoid arthritis: the role of insulin resistance. | 23311682 |
| Refractory anemias, Endothelial dysfunction | Deregulated Nutrient Sensing | HOMA, a strong indicator of insulin resistance, seems to be the main predictor of elevated ADMA levels in RA patients; ADMA may reflect an important pathway linking abnormal insulin metabolism with endothelial dysfunction in RA. | 23311682 |
| Dyslipidemias | Deregulated Nutrient Sensing | Rosuvastatin + fenofibric acid may be more efficacious than rosuvastatin alone in patients with mixed dyslipidemia. | 23312049 |
| Glucose Intolerance (disease), Kidney Failure | Deregulated Nutrient Sensing | Typically, the offspring of animals that are undernourished in pregnancy exhibit a relatively narrow range of physiological phenotypes that includes higher blood pressure, glucose intolerance, renal insufficiency and increased adiposity. | 23312451 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Atorvastatin ameliorates podocyte injury in patients with type 2 diabetes complicated with dyslipidemia. | 23312613 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Although coronary heart disease in users of combined oral contraceptives (COCs) is rare, one of the principal risk factors for its occurrence is dyslipidemia. | 23312931 |
| Increased insulin level, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance, characterized by hyperinsulinemia and normal or elevated serum glucose, is an established precursor to diabetes and cardiovascular disease. | 23316320 |
| Dyslipidemias | Deregulated Nutrient Sensing | Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia. | 23316323 |
| Apolipoproteins B, Lipolysis, Dyslipidemias, Hypertriglyceridemia | Deregulated Nutrient Sensing | Inappropriate storage of fatty acids as triglycerides in adipocytes and their removal from adipocytes through lipolysis and subsequent oxidation may cause the atherogenic dyslipidemia phenotype of elevated apolipoprotein B levels and subsequent hypertriglyceridemia. | 23316323 |
| Dyslipidemias | Deregulated Nutrient Sensing | This suggests a hitherto unknown role of triglyceride turnover in adipocytes for the development and/or maintenance of atherogenic dyslipidemia. | 23316323 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study. | 23320821 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although dyslipidemia is associated with insulin resistance (IR) and type 2 diabetes (T2D), there are limited data available regarding the relationship of LPL and 25(OH)D to IR and T2D at a population level. | 23320821 |
| Leukemia, Myelocytic, Acute | Deregulated Nutrient Sensing | The mTORC1 signaling pathway is constitutively activated in almost all acute myelogenous leukemia (AML) patients. | 23321953 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | If ucOC plays a similar role in humans, then antiresorptive therapies, which reduce ucOC levels, may increase the risk of insulin resistance and diabetes. | 23322676 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | The most prevalent dyslipidemias in Mexico are low high-density lipoprotein (HDL) and high triglyceride (TG) levels. | 23323877 |
| Primary malignant neoplasm, Dyslipidemias, Hyponatremia, Diabetes Mellitus, Congestive heart failure, Hypertension, CTCAE, Liver Cirrhosis | Deregulated Nutrient Sensing | Hyponatremia remained significantly associated with mortality after adjustment for age, gender, ethnicity, diabetes, hypertension, dyslipidemia, smoking, alcohol use, renal function, plasma C-reactive protein, use of antiepileptic drugs and selective serotonin reuptake inhibitors, and history of congestive heart failure, cirrhosis, and cancer (hazard ratio of 1.75). | 23325088 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Association of insulin resistance indexes to carotid intima-media thickness. | 23326550 |
| Blood Vessel, Carotid Intima-Media Thickness, Cardiovascular Diseases | Deregulated Nutrient Sensing | Accumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima-media thickness (IMT), an indicator of vascular damage. | 23326550 |
| Sleep Apnea, Obstructive, Hypoxia, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Obstructive sleep apnea is a risk factor for dyslipidemia and atherosclerosis, which have been attributed to chronic intermittent hypoxia (CIH). | 23328524 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | To examine whether CIH induces dyslipidemia and atherosclerosis by increasing adipose Angptl4 via hypoxia-inducible factor-1 (HIF-1). | 23328524 |
| Neoplasms | Deregulated Nutrient Sensing | SIRT1 has also been shown to be involved in multiple tumors. | 23332867 |
| Interstitial tissue of prostate, Skeletal muscle structure | Deregulated Nutrient Sensing | In nonneoplastic tissue, strong cytoplasmic SIRT1 reactivity was observed in all prostate stroma, smooth muscle, and striated muscle. | 23332867 |
| Neoplasms | Deregulated Nutrient Sensing | Although the physiologic role of SIRT1 remains to be clarified in myoid tissues and neoplasms differentiating along these lines, this observation points to a potential role for this marker in diagnostic immunohistochemistry. | 23332867 |
| Neoplasms | Deregulated Nutrient Sensing | Additional studies are necessary to further characterise the role of SIRT1 in myoid tissues and neoplasms. | 23332867 |
| Weight decreased | Deregulated Nutrient Sensing | Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet. | 23333123 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | We previously demonstrated that angiopoietin-like protein 2 (Angptl2), a pro-inflammatory factor secreted by adipose tissue, promotes adipose tissue inflammation and subsequent systemic insulin resistance in obesity. | 23333801 |
| Prostate Cancer Outcomes Study, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Of 252 patients with PCOS, 41 had glucose intolerance (IGT 14.3%; T2DM 2%) when compared with 10 of the 117 control patients (IGT 8.5%; T2DM 0%; odds ratios = 2.08; P = 0.045) during the OGTT. | 23335611 |
| Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | [Prevalence of dyslipidemia and elevated cardiovascular risk in patients with rheumatoid arthritis]. | 23335702 |
| Glucose Intolerance (disease), IGHD1-7 gene, Diabetes Mellitus | Deregulated Nutrient Sensing | PNP was somewhat more frequent in DM1 patients with glucose intolerance and diabetes mellitus (66.7 vs. 33.7%, P = 0.05). | 23336676 |
| Demyelination, Diabetes Mellitus, Glucose Intolerance (disease), Thyroid dysfunction, IGHD1-7 gene | Deregulated Nutrient Sensing | In DM1 patients with no glucose intolerance, diabetes mellitus and thyroid dysfunction, the most frequent type of PNP was demyelinating (70.0%) and motor (83.3%). | 23336676 |
| Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Smoking (82%), hypertension (40%), and diabetes (30%) were the most common risk factors; ischemic heart disease (4%), obesity (2%), and dyslipidemia (3%) were rare. | 23336851 |
| Autosomal Recessive Disorder, Familial generalized lipodystrophy | Deregulated Nutrient Sensing | Berardinelli-Seip congenital lipodystrophy (BSCL) syndrome is an autosomal recessive disorder, caused by mutation in the AGPAT2 gene, which could lead to insulin resistance and variety of complications. | 23337016 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | SIRT1 is purposed to promote longevity and to suppress the initiation of some cancers. | 23339189 |
| Neoplasms | Deregulated Nutrient Sensing | Nevertheless, SIRT1 is reported to function as a tumor suppressor as well as an oncogenic protein. | 23339189 |
| Liver carcinoma, Neoplasms, FAM126A gene | Deregulated Nutrient Sensing | Our data show that compared with normal liver or surrounding tumor tissue, SIRT1 is strongly overexpressed in human hepatocellular carcinoma (HCC). | 23339189 |
| FAM126A gene | Deregulated Nutrient Sensing | In addition, human HCC cell lines (Hep3B, HepG2, HuH7, HLE, HLF, HepKK1, skHep1) were screened for the expression of the sirtuin family members and only SIRT1 was consistently overexpressed compared with normal hepatocytes. | 23339189 |
| FAM126A gene | Deregulated Nutrient Sensing | To determine its effect on HCC growth, SIRT1 activity was inhibited either with lentiviruses expressing short hairpin RNAs or with the small molecule inhibitor, cambinol. | 23339189 |
| Neoplasms | Deregulated Nutrient Sensing | In an orthotopic xenograft model, knockdown of SIRT1 resulted in 50% fewer animals developing tumors and cambinol treatment resulted in an overall lower tumor burden. | 23339189 |
| Neoplasms, FAM126A gene | Deregulated Nutrient Sensing | Taken together, our data show that inhibition of SIRT1 in HCC cells impairs their proliferation in vitro and tumor formation in vivo. | 23339189 |
| FAM126A gene | Deregulated Nutrient Sensing | These data suggest that SIRT1 expression positively influences the growth of HCC and support further studies aimed to block its activity alone or in combination as a novel treatment strategy. | 23339189 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | 20/(fasting C-peptide x fasting plasma glucose) is a simple and effective index of insulin resistance in patients with type 2 diabetes mellitus: a preliminary report. | 23339473 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We developed a simple and new insulin resistance index derived from a glucose clamp and a meal tolerance test (MTT) in Japanese patients with type 2 diabetes mellitus. | 23339473 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | 20/(F-CPR x FPG) is a simple and effective index of insulin resistance, and performs better than HOMA-IR and ISI in Japanese patients with type 2 diabetes mellitus. | 23339473 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | First Nations people with diabetes, hypertension, or dyslipidemia who were referred to the clinic. | 23341675 |
| SLC25A20 gene | Deregulated Nutrient Sensing | The objective of this study was to evaluate the relationship between insulin resistance and the presence of coronary artery calcium (CAC) to identify risk factors that may predispose young men and women to CVD. | 23341938 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Finally, after adjustment for traditional CVD risk factors, insulin resistance remained an independent predictor of CAC only in men (p = 0.03). | 23341938 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Unlike men, insulin resistance was not a predictor of CAC in women in this cohort. | 23341938 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Therefore, insulin resistance has less impact on CVD risk and CAC in young women compared with men, and insulin resistance alone does not explain the gender disparity in CVD risk that is observed at an early age. | 23341938 |
| Impaired T cell function | Deregulated Nutrient Sensing | High-fat diet is associated with obesity-mediated insulin resistance and b-cell dysfunction in Mexican Americans. | 23343677 |
| Impaired T cell function, Obesity | Deregulated Nutrient Sensing | Consumption of energy-dense, nutrient-poor foods has contributed to the rising incidence of obesity and may underlie insulin resistance and b-cell dysfunction. | 23343677 |
| Impaired T cell function | Deregulated Nutrient Sensing | These findings suggest that high-fat diets may contribute to increased adiposity and concomitant insulin resistance and b-cell dysfunction in Mexican Americans. | 23343677 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Muscle insulin resistance, one of the earliest defects associated with type 2 diabetes, involves changes in the phosphoinositide 3-kinase/Akt network. | 23344726 |
| Obesity | Deregulated Nutrient Sensing | The relative contribution of obesity vs insulin resistance to perturbations in this pathway is poorly understood. | 23344726 |
| Atherosclerosis | Deregulated Nutrient Sensing | The association of alanine aminotransferase within the normal and mildly elevated range with lipoproteins and apolipoproteins: the Insulin Resistance Atherosclerosis Study. | 23344727 |
| Atherosclerosis | Deregulated Nutrient Sensing | In this analysis we included 824 non-diabetic participants (age 40-69 years) in the Insulin Resistance Atherosclerosis Study. | 23344727 |
| Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Cardiovascular disease (CVD) prevention in diabetes requires broad-based treatment of dyslipidemia, hypertension, and hyperglycemia. | 23345072 |
| Extrahepatic, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | This finding suggests that hepatic and extrahepatic insulin resistance causes or exacerbates postprandial glucose intolerance in IFG/IGT. | 23345093 |
| Insulin resistance - type A, Lung Diseases, Interstitial, Autoimmune hypoglycemia, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Type B insulin-resistance syndrome presenting as autoimmune hypoglycemia, associated with systemic lupus erythematosus and interstitial lung disease. | 23346003 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The significance of regular screening and aggressive treatment of other risk factors (i.e., diabetes, hypertension, and dyslipidemia) should not be overlooked. | 23347246 |
| Autosomal Recessive Disorder, Rabson-Mendenhall Syndrome, RMS | Deregulated Nutrient Sensing | Rabson-Mendenhall syndrome (RMS) is an autosomal recessive disorder characterized by extreme insulin resistance and certain characteristic phenotypic features. | 23347304 |
| Hypertension, CTCAE, Coronary Artery Disease | Deregulated Nutrient Sensing | Heart rate and double product in relation to insulin resistance in patients with hypertension and coronary artery disease. | 23348533 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated values of heart rate (HR) and insulin resistance (IR) reflect enhanced sympathetic nervous system activity and may be connected to the development of coronary artery disease (CAD) and diabetes. | 23348533 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | Sirtuin 1 (SIRT1) has been implicated in telomere maintenance and the growth of hepatocellular carcinoma (HCC). | 23348706 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. | 23349498 |
| Obesity | Deregulated Nutrient Sensing | Since glucose-dependent insulinotropic polypeptide (GIP) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate OPN expression in adipose tissue and thereby induce insulin resistance. | 23349498 |
| Inflammation | Deregulated Nutrient Sensing | Together, these data suggest a role for GIP not only as an incretin hormone but also as a trigger of inflammation and insulin resistance in adipose tissue. | 23349498 |
| Obesity | Deregulated Nutrient Sensing | Because obesity also induces macrophage recruitment into adipose tissue, we elucidated here the role of Cbl-b in obesity-related insulin resistance. | 23349502 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity is an established risk factor for type 2 diabetes (T2D) and they are metabolically related through the mechanism of insulin resistance. | 23349771 |
| Overweight | Deregulated Nutrient Sensing | The effect of leptin in obese and overweight population on insulin resistance was seldom reported. | 23349940 |
| Obesity | Deregulated Nutrient Sensing | This may suggest that serum leptin concentration is an important predictor of insulin resistance and other metabolic risks irrespective of obesity levels. | 23349940 |
| Communicable Diseases, No metabolic abnormalities, Hepatitis C, Steatohepatitis | Deregulated Nutrient Sensing | Persistent hepatitis C virus (HCV) infection often evokes metabolic abnormalities including hepatic steatosis and insulin resistance. | 23351407 |
| Steatohepatitis, Lymphoproliferative Disorder of the Skin | Deregulated Nutrient Sensing | We hypothesized that the relationship between the ratio of IGF-I/IGFBP-3 and the severity of hepatic steatosis or insulin resistance would be observed in patients with HCV-related chronic liver disease (CLD). | 23351407 |
| Steatohepatitis, Zinc deficiency | Deregulated Nutrient Sensing | These findings suggest that the decline of the circulating free IGF-I level, which derives from zinc deficiency, may contribute to hepatic steatosis and insulin resistance in patients with HCV-related CLD. | 23351407 |
| Overweight | Deregulated Nutrient Sensing | Young overweight and obese women with lower circulating osteocalcin concentrations exhibit higher insulin resistance and concentrations of C-reactive protein. | 23351412 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | ApoC-I and H5C levels very early in life may affect the development of dyslipidemia and obesity in childhood. | 23351580 |
| Dyslipidemias, Demographics Domain, carotid disease, Diabetes Mellitus | Deregulated Nutrient Sensing | The patients with CAD were more likely to have diabetes mellitus (DM; P = .001), dyslipidemia (P = .013), and bilateral carotid disease (P = .033). | 23352686 |
| Cessation of life, GDC Comorbidity Terminology, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance is highly prevalent after stroke, contributing to comorbid cardiovascular conditions that are the leading cause of death in the stroke population. | 23352685 |
| Sarcopenia, muscle mass | Deregulated Nutrient Sensing | The myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e. | 23354683 |
| Charge Type Reason - Intolerance | Deregulated Nutrient Sensing | The following risk factors were found to be associated with events: male gender, coexisting diabetes/glucose intolerance and elevation of Lp(a) concentrations. | 23357140 |
| Inflammation, Metabolic Diseases | Deregulated Nutrient Sensing | Increased inflammation and oxidative stress are associated with insulin resistance (IR) and metabolic disorders. | 23361591 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Subjects with NWO had a lower appendicular skeletal muscle mass, a more atherogenic lipid profile and greater insulin resistance. | 23362933 |
| Triglycerides, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | After complex weighting, among elderly, the overall prevalence of hypertension was 66.9%, and the rates were greater in the eastern areas (67.9%) than in the western areas (62.5%) (P < 0.05), there was no significant difference between urban areas and rural areas (P > 0.05); the prevalence of diabetes was 19.6%, the rates were greater in the eastern areas (21.5%) than in the western areas (17.7%) (P < 0.05), and greater in the urban areas (25.0%) than in the rural areas (17.0%) (P < 0.05) ; the prevalence of high triglycerides, high blood cholesterol and high low-density lipoprotein were all higher in the urban areas (12.4%, 6.4% and 5.2%) than in the rural areas (10.1%, 4.2% and 2.8%) (all P values < 0.05), and also higher for women (12.9%, 6.9% and 4.7%) than for men (8.7%, 2.9% and 2.4%) (all P values < 0.05); the prevalence of hypertension in people with abnormal blood lipids (74.3%) was higher than those with normal blood lipids (65.7%) (P < 0.05); the prevalence of hypertension and dyslipidemia in people with diabetes (77.3%, 23.2%) were both greater than the prevalence in non-diabetic group (64.5%, 12.6%) (both P values < 0.05). | 23363868 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The rates of diabetes and dyslipidemia were significantly higher in the urban areas than in the rural areas. | 23363868 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | However, prospective studies investigating the relation between vitamin D inadequacy and incidence of T2D incorporating obesity and dynamic measures of insulin resistance (IR) and pancreatic b cell function are limited. | 23364011 |
| Hyperglycemia, Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Obesity and overweight, hyperglycemia and dyslipidemia were the most important abnormal metabolism that related to decreased androgen indices. | 23368725 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In the present study, we found that serum irisin levels were decreased in T2D patients and inversely associated with newly diagnosed T2D, suggesting that irisin may play a crucial role in glucose intolerance and T2D. | 23369227 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Ezetimibe reduced atherogenic lipoproteins in patients with diabetes and glucose intolerance; besides, it improved glucose metabolism in patients with insulin resistance. | 23369229 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Effects of ezetimibe on atherogenic lipoproteins and glucose metabolism in patients with diabetes and glucose intolerance. | 23369229 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Seventy-six patients with diabetes and glucose intolerance were enrolled in this study. | 23369229 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is a key element in the pathogenesis of type 2 diabetes mellitus. | 23369247 |
| Gestational Diabetes, Overweight, Obesity | Deregulated Nutrient Sensing | Although the nature of gestational diabetes mellitus (GDM) remains unclear, the condition is thought to be related primarily to insulin resistance, overweight and obesity. | 23369626 |
| Gestational Diabetes | Deregulated Nutrient Sensing | However, despite normoglycaemia, women with a history of GDM were characterized by significantly impaired insulin secretion, but no signs of increased insulin resistance. | 23369626 |
| Sedentary | Deregulated Nutrient Sensing | The occurrence of age-related diseases, therefore, reflects the synergistic interaction between our evolutionary path to sedentarism, which chronically increases a number of mTOR activating gero-promoters (e.g., food, growth factors, cytokines and insulin) and the "defective design" of central metabolic integrators such as mTOR and AMPK. | 23370395 |
| TG gene, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Our results regarding Japanese patients receiving dyslipidemia treatment for CHD prevention identified insufficient reductions in the levels of LDL-C and TG in those at high risk for CHD and suggest the need for more aggressive lipid-lowering therapy. | 23370735 |
| Liver carcinoma, Hepatic impairment, Liver Dysfunction | Deregulated Nutrient Sensing | Perioperative exercise therapy for patients with hepatocellular carcinoma with liver dysfunction may improve insulin resistance associated with hepatic impairment and suggests a benefit to the early resumption of daily exercise after hepatectomy. | 23374372 |
| Obesity | Deregulated Nutrient Sensing | Association of monocyte CCR2 expression with obesity and insulin resistance in postmenopausal women. | 23374597 |
| Obesity | Deregulated Nutrient Sensing | These results provide support for significant associations of monocyte number and markers involved in monocyte activation with obesity and insulin resistance. | 23374597 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Acanthosis nigricans is a cutaneous manifestation of insulin resistance. | 23374951 |
| Sepsis, Hyperglycemia | Deregulated Nutrient Sensing | Hyperglycemia and insulin resistance are commonplace in critical illness, especially in patients with sepsis. | 23375099 |
| Renal Insufficiency, Atherosclerosis | Deregulated Nutrient Sensing | A low high-density lipoprotein cholesterol, insulin resistance phenotype occurs in subjects with mild renal dysfunction and is associated with elevated monocytes and atherosclerosis. | 23378299 |
| Dyslipidemias, LAURIN-SANDROW SYNDROME | Deregulated Nutrient Sensing | No significant difference in the proportion of patients with dyslipidemia was apparent between the LSS and control groups. | 23380819 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease. | 23382833 |
| Atherosclerosis | Deregulated Nutrient Sensing | Sirt1 regulates transcription factors involved in inflammatory processes and blunts atherosclerosis in mice. | 23382833 |
| Atherosclerosis | Deregulated Nutrient Sensing | This study was therefore designed to investigate the role of Sirt1 in the development of atherosclerosis. | 23382833 |
| GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | HDL from healthy subjects stimulated Sirt1 expression in THP-1 monocytes to a higher degree than HDL from CAD and ACS patients (P<0.05). | 23382833 |
| GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | Monocytic Sirt1 expression is reduced in patients with stable CAD and ACS. | 23382833 |
| Carcinogenic Chlorinated Hydrocarbon, Fatty degeneration | Deregulated Nutrient Sensing | CD36 is linked to steatosis and insulin resistance in patients with G1 CHC, but does not predict response to treatment. | 23383656 |
| Demographics Domain, Cardiovascular Diseases, Communicable Diseases, Ancriviroc, Hepatitis C, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Chronic hepatitis C virus (CH-C) infection is associated with metabolic conditions such as insulin resistance and type 2 diabetes (DM) and may increase the risk of cardiovascular diseases. | 23384408 |
| Ancriviroc, Hypertension, CTCAE | Deregulated Nutrient Sensing | In multivariate analysis, in addition to known risk factors for insulin resistance, CH-C was independently associated with the presence of insulin resistance [OR (95% CI) = 2.06 (1.19-3.57)], DM [OR = 2.31 (1.18-4.54)] and hypertension [OR = 2.06 (1.30-3.24)]. | 23384408 |
| Hypertension, CTCAE, Hepatitis C, Diabetes Mellitus, Congestive heart failure | Deregulated Nutrient Sensing | Chronic hepatitis C virus infection is independently associated with presence of metabolic conditions (insulin resistance, type 2 diabetes mellitus and hypertension) and congestive heart failure. | 23384408 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes (p<0.001), dyslipidemia (p=0.03) and obesity (p<0.001) were less prevalent in this group of patients. | 23385010 |
| Abdominal aortic calcification, Diabetes Mellitus, Non-Insulin-Dependent, Stable Isotope Labeling with Amino Acids in Cell Culture | Deregulated Nutrient Sensing | Abdominal aortic calcification (AAC) is an indicator of cardiovascular risk, especially in the diseases characterized by insulin resistance such as type 2 diabetes. | 23386651 |
| TSC22D3 gene | Deregulated Nutrient Sensing | No difference in glycosphingolipid metabolism and mitochondrial function in glucocorticoid-induced insulin resistance in healthy men. | 23386653 |
| Mitochondria, Muscle | Deregulated Nutrient Sensing | In this study we measured whether GC-induced insulin resistance in humans is related to changes in muscle ceramide, GM3, and muscle mitochondrial function. | 23386653 |
| Hypertensive disease, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | In summary, these data suggest a complex relationship between inflammation and HTN with dyslipidemia. | 23388885 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Association of dyslipidemia with renal outcomes in chronic kidney disease. | 23390545 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is highly prevalent in patients with chronic kidney disease (CKD) and the relationship between dyslipidemia with renal outcomes in patients with moderate to advanced CKD remains controversial. | 23390545 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hence, our objective is to determine whether dyslipidemia is independently associated with rapid renal progression and progression to renal replacement therapy (RRT) in CKD patients. | 23390545 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Our study demonstrated that certain levels of dyslipidemia were independently associated with RRT and rapid renal progression in CKD stage 3-5. | 23390545 |
| Increased insulin level, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The pathophysiology of PCOS is not fully clarified, but is well established the fundamental role of the insulin resistance and the hyperinsulinemia. | 23390858 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The insulin resistance was improved in 80% of the PCOS patients after six months therapy with Metformin 2 x 850 mg/p.d. | 23390858 |
| Diastolic blood pressure, Dyslipidemias | Deregulated Nutrient Sensing | However, conventional risk factors such as smoking, dyslipidaemia, systolic and diastolic blood pressure and pulse pressure had no significant effect. | 23392089 |
| Myocardial Infarction | Deregulated Nutrient Sensing | Only a weak correlation was observed between the presence of subclinical myocardial necrosis and either glycemic control (r = 0.06; P = 0.044 for hemoglobin A1c versus cTnI) or insulin resistance (r = 0.04; P = 0.094 for glucose-to-insulin ratio versus cTnI). | 23393213 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Blockade of receptor activator of nuclear factor-kB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. | 23396210 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM) and is tightly coupled with excessive storage of fat and the ensuing inflammation within the liver. | 23396210 |
| Impaired T cell function | Deregulated Nutrient Sensing | There is compelling evidence that activation of the transcription factor nuclear factor-kB (NF-kB) and downstream inflammatory signaling pathways systemically and in the liver are key events in the etiology of hepatic insulin resistance and b-cell dysfunction, although the molecular mechanisms involved are incompletely understood. | 23396210 |
| Adult Non-Hodgkin Lymphoma | Deregulated Nutrient Sensing | Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma. | 23396962 |
| Adult Non-Hodgkin Lymphoma, RTEL1 gene | Deregulated Nutrient Sensing | We conducted a population-based genetic association study to examine the impact of mutations in AMPK subunit genes on risk of non-Hodgkin lymphoma (NHL). | 23396962 |
| RTEL1 gene, B-Cell Lymphomas | Deregulated Nutrient Sensing | Further, both of these subunits were differentially expressed (P < 0.05) in one or more lymphoma cell type, and higher expression of two versions of the AMPK-b subunit was significantly associated with increased 5-year survival among patients with NHL (P = 0.001 and P = 0.021). | 23396962 |
| RTEL1 gene | Deregulated Nutrient Sensing | These results provide evidence for AMPK involvement in the pathogenesis and progression of NHL. | 23396962 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dietary patterns in Greenland and their relationship with type 2 diabetes mellitus and glucose intolerance. | 23399043 |
| Glucose Intolerance (disease), IFNG wt Allele | Deregulated Nutrient Sensing | The imported meat diet seemed the best in relation to glucose intolerance, with lowest fasting plasma glucose and lowest odds for IFG and T2DM. | 23399043 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Although many post-mortem studies have found evidence of central insulin resistance in Alzheimer's disease (AD) patients, results on changes of central insulin-like growth factor-1 (IGF-1) signaling in the pathological process of AD remain controversial. | 23401344 |
| Vascular System Injuries, Thrombus, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | The aim of this study was to show that the connection between DM and other risk factors, such as dyslipidemia, inflammatory phenomena, or the development of certain vascular injuries, leads to a high frequency of thrombotic events in diabetic patients compared to the nondiabetic population. | 23401641 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Coronary Artery Disease, Heart failure, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Major co-existing diseases were hypertension (60.6%), heart failure (27.9%), diabetes (23.2%), stroke (19.4%), coronary artery disease (15.0%), myocardial infarction (6.4%), dyslipidemia (42.4%), and chronic kidney disease (26.4%). | 23403369 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Previous studies have suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and urinary albumin excretion rate (UAE) in normoalbuminuric patients with normal renal function. | 23404243 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of obesity, diabetes, hyperglycemia, dyslipidemia, and hypertension in one such population, the Micronesian island of Kosrae was described. | 23404778 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Subjects with a high BF% had a significantly higher prevalence of high blood pressure (men only), hyperglycemia, and dyslipidemia. | 23404833 |
| Hyperglycemia, Primary malignant neoplasm, Diabetes Mellitus | Deregulated Nutrient Sensing | Known associations between diabetes and cancer could logically be attributed to hyperglycemia, hypersecretion of insulin, and/or insulin resistance. | 23405181 |
| Non-alcoholic Fatty Liver Disease, Obesity, Abdominal | Deregulated Nutrient Sensing | In subgroup analysis after multiple adjustments, significant relation between serum potassium level and prevalent NAFLD was detected in women, younger subjects, those with insulin resistance and those with central obesity, respectively. | 23405890 |
| Steatohepatitis, Glucose Intolerance (disease), Hepatitis C | Deregulated Nutrient Sensing | Amino acid substitutions in the core region associate with insulin resistance in chronic hepatitis C. Hepatitis C virus (HCV) core protein can induce liver steatosis and glucose intolerance in transgenic mice. | 23406967 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Chronic | Deregulated Nutrient Sensing | We aimed to clarify the association of HCV core region heterogeneity with the development of insulin resistance (IR) among patients with chronic hepatitis C (CHC). | 23406967 |
| Sarcopenia | Deregulated Nutrient Sensing | Diagnostic criteria for sarcopenia relate differently to insulin resistance. | 23407994 |
| Sarcopenia | Deregulated Nutrient Sensing | Sarcopenia is, therefore, a possible risk factor for insulin resistance. | 23407994 |
| Malignant Head and Neck Neoplasm | Deregulated Nutrient Sensing | Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in head and neck cancers, and it has been demonstrated that inhibition of mTOR complex 1 sensitizes cell lines to platinum and taxane chemotherapy. | 23408298 |
| Increased insulin level, Diabetes Mellitus | Deregulated Nutrient Sensing | Abdominal myosteatosis is independently associated with hyperinsulinemia and insulin resistance among older men without diabetes. | 23408772 |
| Increased insulin level | Deregulated Nutrient Sensing | A previously unreported, independent association between abdominal myosteatosis and hyperinsulinemia and insulin resistance among older Caucasian men was indicated. | 23408772 |
| Neuropathy, Dyslipidemias, Hypertension, CTCAE, Ulcer | Deregulated Nutrient Sensing | RECOMMENDATIONSs: We recommend strengthening of routine screening for neuropathy, to emphasis on foot ulcer risk reduction, management of co-morbidities like hypertension and dyslipidemia, to optimize treatment of painful neuropathy. | 23409395 |
| Dyslipidemias | Deregulated Nutrient Sensing | Recent studies have suggested that dietary Ca may have beneficial effects on adiposity, insulin resistance, dyslipidaemia and blood pressure (BP). | 23411109 |
| Obesity, Abdominal, Overweight, Obesity | Deregulated Nutrient Sensing | Subjects in the HCG had lower OR for prevalent overweight, obesity, abdominal obesity, insulin resistance, HDL-cholesterol < 600 mg/l and systolic BP >120 mmHg. | 23411109 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia in chronic kidney disease in Nepalese population. | 23416824 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is a potential risk factor for CVD in CKD cases. | 23416824 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In this study our aim was to find out the dyslipidaemia in patients with different stages of CKD. | 23416824 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | CKD had a higher prevalence of dyslipidaemia compared to non-CKD controls. | 23416824 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia was also found in early stages of CKD. | 23416824 |
| Primary malignant neoplasm, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are risk factors for cancer development. | 23418314 |
| Pliability, Diabetes Mellitus, Non-Insulin-Dependent, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have been implicated in the etiology of type 2 diabetes (T2D), yet their interrelationship remains speculative. | 23418416 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Metabolic Syndrome X | Deregulated Nutrient Sensing | While nonalcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome, it is not known if NAFLD plays an independent role in the atherogenic dyslipidemia phenotype. | 23419204 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | In a large, multi-ethnic, gender balanced cohort, CT-diagnosed NAFLD was associated with the atherogenic dyslipidemia phenotype in a dose dependent fashion. | 23419204 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | These relationships persisted after adjustment for several metabolic risk factors and HOMA-IR, suggesting a possible independent pathophysiologic role between NAFLD and dyslipidemia. | 23419204 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | To explore the impact of cardiac autonomic function (CAF) and insulin resistance (IR) on incident hypertension. | 23419733 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | The risk for coronary heart disease according to insulin resistance with and without type 2 diabetes. | 23425058 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | ORs for CHD increased as insulin resistance increased in both non-diabetic and diabetics. | 23425058 |
| Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance was a greater risk for CHD than type 2 diabetes. | 23425058 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Non-diabetics can have a higher risk for CHD than diabetics when insulin resistance is elevated. | 23425058 |
| Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance, and the risk of an elevated alanine aminotransferase activity in the Korean adolescent population. | 23426824 |
| Obesity | Deregulated Nutrient Sensing | It is unclear to what extent insulin resistance (IR) modulates the association linking obesity to alanine aminotransferase (ALT) activity elevation. | 23426824 |
| Prostate carcinoma, Obesity | Deregulated Nutrient Sensing | Androgen-deprivation therapy (ADT) by either a gonadotropin-releasing hormone (GnRH) agonist or bilateral orchiectomy improves disease-related outcomes of men with prostate cancer but has a variety of adverse metabolic effects including obesity, increased abdominal girth, increased triglycerides, and insulin resistance. | 23428068 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidemia were more common, and the glomerular filtration rate (GFR) was significantly higher, in patients undergoing statin treatment. | 23430269 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In males, the risk of hypertension was significantly (95% CI 1.9, 8.7; p = 0.003) increased by 1.8-fold in the first quartile compared with the highest quartile of RBC 5-MTHF when adjusted for body mass index (BMI), age, dyslipidaemia, uric acid, creatinine, smoking, plasma tHcy and vitamin B(12). | 23430668 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The risk of hypertension was also significantly increased (95% CI 1.1, 9.2; p = 0.03) by 1.1-fold in the highest quartile compared with the lowest quartile of plasma tHcy when adjusted for BMI, age, dyslipidaemia, uric acid, creatinine, smoking, plasma and RBC 5-MTHF and vitamin B(12). | 23430668 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Risk factors, such as hypertension, dyslipidemia, obesity and smoking play an important role in the high prevalence of NCDs. | 23431831 |
| Obesity, Abdominal, Dyslipidemias, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Among anthropometrics and imaging indices of obesity, WC and WHtR have shown better association between central obesity with dyslipidemia in the patients with CHD, while CT-measured visceral adipose tissue area was the best correlate of dyslipidemia in the patients without CHD. | 23432166 |
| Hypertension, CTCAE, Cerebrovascular accident, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patient medical charts were used to obtain the risk factors for stroke, including diabetes, hypertension, dyslipidemia, age, and sex. | 23434443 |
| Dyslipidemias, diabetic, Cardiovascular Diseases | Deregulated Nutrient Sensing | This study showed obese diabetic individuals have dyslipidemia and more prone to develop cardiovascular diseases. | 23434961 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Calcium channel blocker effect on insulin resistance and inflammatory markers in essential hypertension patients. | 23435396 |
| Inflammation, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance, inflammation and oxidative stress (OS), are among the mechanisms that have been implicated in pathogenesis of essential hypertension (EH). | 23435396 |
| Obesity | Deregulated Nutrient Sensing | Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. | 23436919 |
| Obesity | Deregulated Nutrient Sensing | In men, circulating irisin levels were negatively associated with obesity and insulin resistance. | 23436919 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Patients with dyslipidaemia or hypercholesterolemia carry a substantially increased cardiovascular risk and need optimal treatment of this key risk factor. | 23437867 |
| Hypertriglyceridemia, Loss of facial adipose tissue | Deregulated Nutrient Sensing | Lipodystrophies are hypoleptinemic conditions characterized by fat loss, severe insulin resistance, hypertriglyceridemia, and ectopic fat accumulation. | 23439261 |
| Dyslipidemias | Deregulated Nutrient Sensing | The MG-modified Apo A-I level may be an indicator of diabetic dyslipidemia and insulin resistance. | 23440769 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Odds ratios (OR) between hypertension, obesity and dyslipidemia were calculated. | 23441809 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The subjects were 72 patients without diabetes and cardiovascular disease being treated for hypertension or dyslipidemia. | 23442745 |
| Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | In multivariate analyses, family history of diabetes and IGF-I were associated with hyperglycaemia, BMI and IGF-I predicted insulin resistance, and age was inversely correlated with b-cell function. | 23446424 |
| Dyslipidemias, Coronary Artery Disease, F3 wt Allele, Heart failure | Deregulated Nutrient Sensing | Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF). | 23446892 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Together with a family history of dyslipidemia, the patient was diagnosed as having familial hypercholesterolemia. | 23448768 |
| Atherosclerosis | Deregulated Nutrient Sensing | Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the insulin resistance atherosclerosis study. | 23450048 |
| Atherosclerosis | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study had a total of 1107 participants. | 23450048 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Nondiabetic individuals with pre-existing MetS risk factors were recruited for participation in the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study, a longitudinal study of the determinants of insulin resistance and MetS. | 23452164 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Multivariate logistic regression analyses indicated a decreased risk of MetS at follow-up per standard deviation increase in baseline 25(OH)D after adjustment for sociodemographics, season, baseline and change in supplement use and physical activity and insulin resistance (OR = 0*63, 95% CI 0*44-0*90). | 23452164 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients. | 23453030 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | SIRT1, class III histone deacetylase, has been described to be up-regulated in various malignancies. | 23453030 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | Therefore, we investigated SIRT1 expression to clarify its biological behavior and identify its usefulness as a biomarker for head and neck squamous cell carcinoma (HNSCC). | 23453030 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | SIRT1 expression was assessed by immunohistochemistry (IHC) conducted using samples from 437 consecutive HNSCC patients. | 23453030 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was reported by 65.5% of patients, diabetes by 17.9%, dyslipidemia by 58.6%, smoking by 14% and family history of coronary artery disease in 11%. | 23453533 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Demographic data, details on diabetes, hypertension, dyslipidemia and their treatment modalities, various risk factors and complications were updated annually. | 23454736 |
| Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | Comparison of plasma viscosity as a marker of endothelial dysfunction with nitric oxide and asymmetric dimethylarginine in subjects with dyslipidemia. | 23455843 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Plasma viscosity, ADMA and oxLDL values were significantly higher in subjects with dyslipidemia than in subjects with normolipidemia. | 23455843 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance as a predictor of cardiovascular disease in patients on peritoneal dialysis. | 23455976 |
| palladium, ciliary vesicle | Deregulated Nutrient Sensing | However, no evaluation of the impact of insulin resistance on CV disease morbidity or mortality in patients on PD has been performed. | 23455976 |
| ciliary vesicle | Deregulated Nutrient Sensing | A multivariate Cox model was used to analyze the impact of insulin resistance on CV disease mortality. | 23455976 |
| Steatohepatitis, Secondary malignant neoplasm of liver, CST9 gene | Deregulated Nutrient Sensing | Hepatic steatosis, a common condition associated with insulin resistance and excess body weight, is reported to be associated with an increased risk for perioperative mortality in patients undergoing resection of colorectal liver metastases (CLM), but its impact upon longterm survival is less well documented. | 23458109 |
| Cavia, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The aim of this work was to examine whether the CAVI value in patients with dyslipidaemia (DLP) is increased by the presence of other cardiovascular risk factors: hypertension, diabetes mellitus, and smoking. | 23459505 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Additional CVD risk factors included obesity, reduced glomerular filtration rate, and dyslipidemia. | 23460805 |
| Hypercholesterolemia, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes and hypertension were assessed by clinical diagnosis and dyslipidemia (high triglycerides, low HDL-cholesterol, and hypercholesterolemia) by lipid analyses. | 23460844 |
| Dyslipidemias, ETV3 wt Allele | Deregulated Nutrient Sensing | No significant associations were observed for the MetS components high blood pressure, dyslipidemia, or elevated fasting glucose. | 23460844 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Individuals with dyslipidemia, T2DM, or hypertension tended to have a body mass index >= 25 kg/m(2). | 23465284 |
| Each (qualifier value) | Deregulated Nutrient Sensing | Among patients with BE, increased levels of leptin and insulin resistance are associated with increased risk for EA, whereas increased levels of high-molecular-weight adiponectin is associated inversely with EA. | 23466711 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | This demonstrates that chemerin levels are associated with obesity and dyslipidemia and may play a role in the development of insulin resistance. | 23468920 |
| Metabolic Diseases, Hepatitis C, Chronic | Deregulated Nutrient Sensing | Insulin resistance, serum visfatin, and adiponectin levels are associated with metabolic disorders in chronic hepatitis C virus-infected patients. | 23470357 |
| Weight Gain | Deregulated Nutrient Sensing | A possible mechanism of antipsychotic-induced weight gain is activation of hypothalamic monophosphate-dependent kinase (AMPK) mediated by histamine 1 receptors. | 23471087 |
| Tumor necrosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), in addition to having a prognostic value in patients with cardiovascular disease, seems to interact with adiposity, insulin resistance and other cardiovascular risk factors. | 23472162 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Identification of a SIRT1 mutation in a family with type 1 diabetes. | 23473037 |
| Autoimmune Disorder, CTCAE, Diabetes Mellitus, Insulin-Dependent, Ulcerative Colitis | Deregulated Nutrient Sensing | Here we describe a family carrying a mutation in the SIRT1 gene, in which all five affected members developed an autoimmune disorder: four developed type 1 diabetes, and one developed ulcerative colitis. | 23473037 |
| Autoimmune Diseases, Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | These observations identify a role for SIRT1 in human autoimmunity and unveil a monogenic form of type 1 diabetes. | 23473037 |
| Dyslipidemias, Demographics Domain, Hypertension, CTCAE | Deregulated Nutrient Sensing | Vitamin B12 levels were significantly lower and Hcy levels were significantly higher in subjects with dyslipidemia, DM, and/or hypertension. | 23473764 |
| Breast Carcinoma | Deregulated Nutrient Sensing | CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1. | 23474493 |
| Breast Carcinoma | Deregulated Nutrient Sensing | We provide the first evidence that CBX8 plays a potential role in regulating premature senescence in human breast cancer cells through cooperation with SIRT1. | 23474493 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: interim outcomes from the GREAT2DO trial. | 23474589 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | In addition, the combination increased UA, and hsCRP was also a significant and independent determinant for MetS and insulin resistance. | 23475511 |
| Progranulins, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. | 23476101 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. | 23476101 |
| Hypoadiponectinemia | Deregulated Nutrient Sensing | A novel mechanism for vascular insulin resistance in normotensive young SHRs: hypoadiponectinemia and resultant APPL1 downregulation. | 23478100 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Vascular insulin resistance contributes to elevated peripheral vascular resistance and subsequent hypertension. | 23478100 |
| Periodontitis, Dyslipidemias | Deregulated Nutrient Sensing | The association between periodontitis and dyslipidemia based on the Fourth Korea National Health and Nutrition Examination Survey. | 23480442 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia is defined according to the definition proposed by the Korean Society of Lipidology and Atherosclerosis. | 23480442 |
| Hypercholesterolemia, Periodontitis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia except pre-hypercholesterolemia is associated with periodontitis. | 23480442 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a significant risk factor for premature cardiovascular disease. | 23480991 |
| Postmenopausal state, Primary Biliary Cholangitis, Obesity | Deregulated Nutrient Sensing | The constellation of obesity, insulin resistance, and serum adipocytokine levels is associated with the risk and prognosis of postmenopausal breast cancer (PBC). | 23481121 |
| Hypertension, CTCAE, Lack of awareness finding, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Level of unawareness and management of diabetes, hypertension, and dyslipidemia among adults in Luxembourg: findings from ORISCAV-LUX study. | 23483942 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among the diagnosed cases, 32%, 60%, and 85% were respectively unaware of their diabetes, hypertension and dyslipidemia. | 23483942 |
| Hypertension, CTCAE, Lack of awareness finding, Dyslipidemias | Deregulated Nutrient Sensing | Increasing age and BMI were the strongest protective factors against unawareness of hypertension and dyslipidemia. | 23483942 |
| Dyslipidemias, Lack of awareness finding | Deregulated Nutrient Sensing | Poor health perception reduced significantly the risk of unawareness of dyslipidemia (OR = 0.27; 95% CI 0.11, 0.68). | 23483942 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Concerning the management, diabetes was markedly better treated than hypertension and dyslipidemia. | 23483942 |
| Dyslipidemias, Lipid Metabolism Disorders | Deregulated Nutrient Sensing | Concerning dyslipidemia, only 9% of those with lipid disorder (70% of the population) were under medication vs. 61% not treated. | 23483942 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | There is a prevalence of 10*4/100,000 schoolchildren with T2DM, and 7*5/100,000 with impaired glucose intolerance among schoolchildren in Trinidad. | 23485494 |
| Left Ventricular Hypertrophy, Aortic valve calcification | Deregulated Nutrient Sensing | Insulin resistance and LVH progression in patients with calcific aortic stenosis: a substudy of the ASTRONOMER trial. | 23489530 |
| Left Ventricular Hypertrophy | Deregulated Nutrient Sensing | In this ASTRONOMER substudy, insulin resistance was a powerful independent predictor of progression to LVH in patients with AS. | 23489530 |
| Obesity, Visceral | Deregulated Nutrient Sensing | Visceral obesity and ensuing insulin resistance may thus present novel therapeutic targets in AS patients. | 23489530 |
| Unipolar Depression | Deregulated Nutrient Sensing | There was a significant negative association between major depression and insulin resistance among men. | 23489875 |
| Depression, CTCAE | Deregulated Nutrient Sensing | There was no significant interaction between race/ethnicity and major depression on insulin resistance (Wald kh(2) = 4.2927, P = 0.2315). | 23489875 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Health care professionals should be aware of risk factors for insulin resistance and develop interventions to help prevent the progression of insulin resistance to type 2 diabetes mellitus. | 23489875 |
| Non-insulin Hypoglycemic | Deregulated Nutrient Sensing | Haplotype G-C was likely associated with non-insulin resistance (adjusted P = 0.011). | 23490372 |
| Dyslipidemias | Deregulated Nutrient Sensing | The same degree of dyslipidaemia was seen when Inuit had a 10% higher BMI compared to non-Inuit. | 23495626 |
| Primary malignant neoplasm, Breast Carcinoma | Deregulated Nutrient Sensing | Homeostasis model assessment to detect insulin resistance and identify patients at high risk of breast cancer development: National Cancer Institute of Naples experience. | 23497533 |
| Carcinogenesis | Deregulated Nutrient Sensing | Therefore we focused specifically on insulin resistance to investigate clinically the potential role of insulin in breast carcinogenesis. | 23497533 |
| Breast Carcinoma | Deregulated Nutrient Sensing | 975 patients were enrolled and the association between MS, insulin resistance, and breast cancer was evaluated. | 23497533 |
| Breast Carcinoma | Deregulated Nutrient Sensing | HOMA-IR score was elevated in 49% of cases compared to 34% of controls [OR 1.86], suggesting that insulin resistance can nearly double the risk of breast cancer development. | 23497533 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Both android fat distribution and insulin resistance correlated to MS in the subgroup of postmenopausal women affected by breast cancer. | 23497533 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Our results further support the hypothesis that MS, in particular insulin resistance and abdominal fat, can be considered as risk factors for developing breast cancer after menopause. | 23497533 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance, subclinical left ventricular remodeling, and the obesity paradox: MESA (Multi-Ethnic Study of Atherosclerosis). | 23500236 |
| Obesity | Deregulated Nutrient Sensing | Recent studies have suggested that central obesity and insulin resistance may be primary mediators of obesity-related cardiac remodeling independent of body mass index (BMI). | 23500236 |
| Obesity | Deregulated Nutrient Sensing | These results support the emerging hypothesis that the cardiometabolic phenotype, defined by insulin resistance and central obesity, may play a critical role in LV remodeling independently of BMI. | 23500236 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Impairment of health-related quality of life in patients with chronic hepatitis C is associated with insulin resistance. | 23503838 |
| Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance (IR) is recognized as a distinct aspect of chronic HCV infection. | 23503838 |
| Obesity | Deregulated Nutrient Sensing | High-normal TSH values in obesity: is it insulin resistance or adipose tissue's guilt? | 23505173 |
| Obesity | Deregulated Nutrient Sensing | Our study suggests that the increase in visceral adipose tissue is the best predictor of TSH concentration in obesity, independently from the eventual concurrent presence of insulin resistance. | 23505173 |
| Sedentary lifestyle, Obesity | Deregulated Nutrient Sensing | Sedentary behavior in children is positively associated with an increased risk of both obesity and insulin resistance. | 23505193 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Taken together, increased DNA methylation of the PPARGC1A promoter is unlikely to play a major causal role for the development of insulin resistance in FDR of patients with T2D. | 23505498 |
| Myeloid Leukemia, Chronic, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | With regards to RAGE-mediated CML trapping into adipose tissue inducing dysregulation of pro-inflammatory cytokines, adipokines, and the development of obesity-related insulin resistance, and the potential involvement of sRAGE in feedback regulation of the toxic effects of AGE/RAGE-mediated signaling, this early decline might be of clinical impact in development of type 2 diabetes and its complications. | 23509221 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The links between obesity and type 2 diabetes include proinflammatory cytokines, insulin resistance, deranged fatty acid metabolism, and cellular processes. | 23510756 |
| Hyperinsulinism, Obesity | Deregulated Nutrient Sensing | Obesity also leads to hyperinsulinaemia and insulin resistance, with a progressive decrease in insulin secretory function. | 23510756 |
| Abnormality of mitochondrial metabolism, Atherosclerosis | Deregulated Nutrient Sensing | Cardiovascular risk factors such as aging, smoking, and insulin resistance may lead to atherosclerosis through various mechanisms of which their association with mitochondrial dysfunction may be one of them. | 23510829 |
| Carotid Atherosclerosis | Deregulated Nutrient Sensing | Attenuation of the association with adjustment for triglyceride/HDL ratio, a marker of insulin resistance, suggests that lactate's association with carotid atherosclerosis may be related to insulin resistance. | 23510829 |
| Cessation of life, Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | the increase in HDL-C and the reduction of insulin resistance and atherogenic LDL subfractions), support findings from the PROactive trial, where pioglitazone showed pleiotropic effects and reduced death, fatal myocardial infarction (MI) and non-fatal MI in T2DM patients with MS. | 23511244 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Previous evidence indicates that pioglitazone may improve dyslipidemia in patients with Type 2 diabetes mellitus (T2DM). | 23511244 |
| Metabolic Diseases, Dyslipidemias, ETV3 wt Allele, Obesity, Hyperuricemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Although MetS was associated with obesity, dyslipidemia, glucose control, hypertension, and hyperuricemia, limited ability of MetS to indicate metabolic disease risk is suggested. | 23512735 |
| Adrenal hyperplasia | Deregulated Nutrient Sensing | Non-classic adrenal hyperplasia (NCAH) has been associated with insulin resistance (IR). | 23513016 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes. | 23517921 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. | 23517921 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The use of PIs has also been associated with dyslipidemia and an increased risk of cardiovascular disease, but the underlying mechanisms remain elusive. | 23519392 |
| Congenital adrenal hyperplasia | Deregulated Nutrient Sensing | Quality of life in adults with congenital adrenal hyperplasia relates to glucocorticoid treatment, adiposity and insulin resistance: United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE). | 23520247 |
| Chronic active hepatitis | Deregulated Nutrient Sensing | Increased adiposity, insulin resistance and use of prednisolone or dexamethasone are associated with impaired QoL in adults with CAH. | 23520247 |
| Non-alcoholic Fatty Liver Disease, Hepatic inflammation | Deregulated Nutrient Sensing | NAFLD is associated with insulin resistance and hepatic inflammation. | 23522007 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Similarly, patients with depression exhibit insulin resistance and increased inflammatory markers. | 23522007 |
| Alzheimers Disease", Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | The current study suggests that in an elderly sample of Alzheimer's caregivers, nighttime sleep duration, nighttime sleep efficiency and daytime naps are not significantly associated with prevalent type 2 diabetes, dyslipidemia, or hypertension. | 23522093 |
| Hyperglycemia, Hypertriglyceridemia, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In the absence of obesity, the presence of fasting hyperglycemia, insulin resistance, hypertriglyceridemia, and/or hypertension defined the presence of MONW phenotype. | 23523313 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | Polymorphisms in mTORC1 genes modulate risk of esophageal squamous cell carcinoma in eastern Chinese populations. | 23524405 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | These findings suggest that functional SNPs of mTORC1 genes may individually or collectively contribute to ESCC risk. | 23524405 |
| Cerebral Ischemia | Deregulated Nutrient Sensing | The effect of insulin resistance on inflammatory response and oxidative stress in acute cerebral ischemia. | 23524624 |
| Inflammation, Acute Cerebrovascular Accidents | Deregulated Nutrient Sensing | Insulin resistance (IR) has effects on inflammation and oxidative stress which have importance in acute stroke. | 23524624 |
| Inflammation, Cerebrovascular accident | Deregulated Nutrient Sensing | Inflammation and oxidative stress are more evident in acute stoke patients with insulin resistance which may cause worse stroke severity. | 23524624 |
| Ischemic stroke | Deregulated Nutrient Sensing | Our data also suggest that IL-10 as an antiinflammatory cytokine can be much lower in insulin resistance in acute phase of ischemic stroke. | 23524624 |
| Fatty Liver | Deregulated Nutrient Sensing | When the participants were categorized by the overall degree of fatty liver, hepatic steatosis was significantly associated with the aspartate aminotransferase level (P = .028), ALT level (P = .003), and diastolic blood pressure (P = .05) but did not correlate with age, sex, Latino race, or insulin resistance. | 23525389 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | BMI was strongly associated with increased relative risk of cardiovascular disease, dyslipidemia, type 2 diabetes, and hypertension in the young and middle aged, however, the association between BMI and these metabolic conditions were much more attenuated with increasing age. | 23525474 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including cancer, unraveling new proximal causes through which AMPK activation endows its gerosuppressive effects may offer not only a better understanding of metformin function but also the likely possibility of repositioning our existing gerosuppressant drugs. | 23525940 |
| Refractory anemias, ETV3 wt Allele | Deregulated Nutrient Sensing | Despite their increased insulin resistance, South Korean women with RA did not have a significantly higher frequency of MetS compared with that in healthy subjects. | 23526131 |
| Glucose Intolerance (disease), Tacca leontopetaloides, Ischemic stroke | Deregulated Nutrient Sensing | Glucose intolerance and insulin resistance as predictors of low platelet response to clopidogrel in patients with minor ischemic stroke or TIA. | 23527528 |
| Glucose Intolerance (disease), Tacca leontopetaloides, Ischemic stroke | Deregulated Nutrient Sensing | The relation between high on-treatment platelet reactivity (HPR), and the level of glucose intolerance and insulin resistance (IR) was studied in clopidogrel-treated patients with minor ischemic stroke or TIA. | 23527528 |
| Glucose Intolerance (disease), metabolic disturbance | Deregulated Nutrient Sensing | A metabolic disturbance with glucose intolerance and/or high level of IR was a pre-requisite for HPR in the tested cohort. | 23527528 |
| Dyslipidemias, Heart failure, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia is a known risk factor for coronary disease, but its role in heart failure (HF) development is less well-defined. | 23529112 |
| Communicable Diseases | Deregulated Nutrient Sensing | The data obtained by the patient's close monitoring suggest a direct interaction between insulin resistance and an active HCV genotype 1 infection, with a leading role played by the infection, and not by insulin resistance, as demonstrated by the sharp fall of the insulin units needed per day during treatment. | 23529134 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | A1C >=5.7% identified the subgroup of PCOS patients with higher insulin resistance, inadequate compensatory insulin response, impaired glucose disposition, and increased cardiovascular risk factors. | 23529348 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | The objectives of this study were to investigate the effects of omega-3 fatty acids on obesity status, insulin resistance, and serum levels of visfatin in PCOS patients. | 23529993 |
| Heart Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Modelling for confounding interactions of concurrent dyslipidaemia, heart disease and other risk factors suggested that this marker is an independent predictor of AAA susceptibility. | 23535823 |
| Cerebral Infarction | Deregulated Nutrient Sensing | Insulin resistance and risk of cerebral infarction in a Japanese general population: the Jichi Medical School Cohort Study. | 23536233 |
| Cerebral Infarction | Deregulated Nutrient Sensing | The aim of the study was to investigate the relation between insulin resistance and risk of cerebral infarction in a Japanese general population. | 23536233 |
| Dyslipidemias, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | Association of dyslipidemia with renal cell carcinoma: a 1:2 matched case-control study. | 23536888 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | MTM members with hypertension and dyslipidemia had pre-post increases in MPR of 2.29% and 2.10%, respectively, while the control group had decreases of 2.31% and 2.61% (both P less than 0.001). | 23537457 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | MTM interventions were associated with a significant decrease in the MTM members' overall plan-paid health care costs, driven largely by decreases in inpatient utilization and mediated by increases in average days supply and in MPR increases for hypertension and dyslipidemia. | 23537457 |
| Colorectal Neoplasms, Dyslipidemias | Deregulated Nutrient Sensing | There is suggestive but sparse evidence that dyslipidemia is associated with colorectal neoplasms. | 23545715 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Insufficient nocturnal HR lowering in women with AH was not associated with significant changes of the myocardium and kidney and clear cat links with dyslipidemia, obesity, and smoking. | 23548350 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes. | 23549584 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Additionally, in a cross-sectional analysis of persons without diabetes, lower nocturnal melatonin secretion was associated with increased insulin resistance. | 23549584 |
| HD Term Type | Deregulated Nutrient Sensing | Studies in different animal models provide convincing evidence that SIRT1 protects neurons in mouse models of HD as well as in Caenorhabditis elegans, although controversial results were reported in a fly model. | 23549885 |
| HD Term Type | Deregulated Nutrient Sensing | As a result, pharmacological interventions targeting SIRT1 might become promising strategies to combat HD. | 23549885 |
| HD Term Type | Deregulated Nutrient Sensing | This review summarizes recent progress in SIRT1 research, with a focus on the specificity of this protein as a potential therapeutic target for HD, as well as existing challenges for developing SIRT1 modulators for clinical use. | 23549885 |
| Huntingtons Disease Pathway | Deregulated Nutrient Sensing | Targeting sirtuin-1 in Huntington's disease: rationale and current status. | 23549885 |
| Dyslipidemias, Electrocardiogram: left ventricle hypertrophy (finding), Kidney Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Of 7032 participants, cardiovascular risk factors were prevalent, with 15.1% current smokers, 26.1% obese, 22.8% with diabetes mellitus, 35.1% with dyslipidemia, 12.0% with left ventricular hypertrophy, and 4.9% with renal insufficiency. | 23551730 |
| Ischemia, Glucose Intolerance (disease), MELAS gene | Deregulated Nutrient Sensing | Excitability of median nerve axons at the wrist was studied in 13 patients with MELAS (6 with glucose intolerance) and 17 control subjects in response to ischemia due to inflation of a cuff around the arm for 10 min. | 23553640 |
| Juvenile arthritis, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Coincident obesity is common in JIA children and is associated with insulin resistance, dyslipidemia, and increased levels of inflammatory markers leading to early changes in cardiovascular system. | 23554546 |
| Obesity | Deregulated Nutrient Sensing | Iron and obesity status-associated insulin resistance influence circulating fibroblast-growth factor-23 concentrations. | 23555610 |
| square decimeter, Erectile dysfunction | Deregulated Nutrient Sensing | In vitro, exposure of cardiomyocytes to conditioned media derived from epicardial adipose tissue from patients with DM2 induced contractile dysfunction and insulin resistance, which was prevented by the addition of recombinant omentin. | 23555749 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Association between dyslipidemia and chronic kidney disease: a cross-sectional study in the middle-aged and elderly Chinese population. | 23557545 |
| Dyslipidemias, Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, a well-known risk factor for cardiovascular disease, is common in patients with kidney disease. | 23557545 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Thus, we assessed whether the growing prevalence of dyslipidemia could increase the risk of CKD. | 23557545 |
| Dyslipidemias, Albuminuria, Chronic Kidney Diseases | Deregulated Nutrient Sensing | As the number of dyslipidemia components increased, so did the OR of CKD: 0.87 (95%CI 0.65 - 1.15), 1.29 (95%CI, 0.83 - 2.01), and 7.87 (95%CI, 3.75 - 16.50) for albuminuria, and 0.38 (95%CI 0.21 - 0.69), 1.92 (95%CI 1.14 - 3.25), and 5.85 (95%CI 2.36 - 14.51) for reduced eGFR, respectively. | 23557545 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Our findings indicate that dyslipidemias increase the risk of CKD in the middle-aged and elderly Chinese population. | 23557545 |
| Prediabetes syndrome, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Multivariate logistic analysis was used to analyze the risk factors of CKD and prediabetes, and association of insulin resistance (IR) with CKD and prediabetes was analyzed. | 23557546 |
| Prediabetes syndrome, Chronic Kidney Diseases | Deregulated Nutrient Sensing | CKD and prediabetes have become a major public health problem in Zhuhai, Southern China; insulin resistance may be an important risk factor. | 23557546 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes-free survival was significantly prolonged when islet yield per gram of pancreas weight was more than 5154 islet equivalents (IEQ)/g, even in patients with prediabetes and high insulin resistance who had a markedly high rate of diabetes development. | 23558506 |
| Pancreatic Neoplasm, Prediabetes syndrome | Deregulated Nutrient Sensing | Partial (50%-60%) pancreatectomy for benign pancreatic tumors had a major metabolic consequence, especially in patients with prediabetes and high insulin resistance. | 23558506 |
| Dyslipidemias | Deregulated Nutrient Sensing | LMDT after AAA is associated with an increased survival compared with patients who were not using drug therapy for dyslipidemia. | 23561430 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Aggressive management of dyslipidemia should be considered in all patients undergoing AAA repair irrespective of other atherosclerotic disease status and risk factor profile. | 23561430 |
| Demographics Domain | Deregulated Nutrient Sensing | The ACS of 3 and greater, which corresponded well to the highest quartile, was significantly and negatively associated with serum OC and ucOC levels in men by logistic regression analyses after adjusting for age, BMI, serum levels of creatinine and LDL cholesterol, radial bone mineral density, smoking, duration of DM, hemoglobin A1c, and the index of insulin resistance [odds ratio (OR) 0.36, 95 % confidence interval (CI) 0.19-0.70, P < 0.005, and OR 0.28, 95 % CI 0.12-0.69, P < 0.01, per standard deviation increase in OC and ucOC, respectively]. | 23563931 |
| Dyslipidemias | Deregulated Nutrient Sensing | We did not find any difference between the group of patients with and that without dyslipidemia and low or normal levels of vitamin D(3). | 23564349 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The findings regarding dyslipidemia, bone markers, and site specificity support the hypothesis that reduced blood flow is the key factor responsible for the inverse association of BMD with atherosclerosis. | 23564349 |
| Thyroid carcinoma | Deregulated Nutrient Sensing | "Is there any association between insulin resistance and thyroid cancer? | 23564559 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | In multivariable analyses, age, hypertension, dyslipidemia, recent CD4(+) cell count <=200 cells/mm(3), and recent HIV RNA >400 copies/ml were associated with an increased risk of CVE. | 23565888 |
| Inflammation, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Vitamin D (VD) may be implicated in obesity and its complications such as insulin resistance, hypertension, and low-grade inflammation. | 23566943 |
| Infarction, Dyslipidemias | Deregulated Nutrient Sensing | This study revealed the increased prevalence of dyslipidemia to be more prevalent in 31-40 year males, suggesting that this group is at an increased risk of developing CAD leading to young infarcts. | 23569786 |
| Hyperthyroidism | Deregulated Nutrient Sensing | Circulating glucagon to ghrelin ratio as a determinant of insulin resistance in hyperthyroidism. | 23572405 |
| Coronary Occlusion, Hypertension, CTCAE, Stenosis Morphology, Dyslipidemias | Deregulated Nutrient Sensing | Within the CAD patient group, dose-response curves of L-selectin showed significant differences in the presence of hypertension, dyslipidemia, coronary occlusion and degree of stenosis, whereas CD11b expression had the strongest discriminating power after single dose stimulation. | 23573259 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance and risk of incident heart failure: Cardiovascular Health Study. | 23575256 |
| Heart failure | Deregulated Nutrient Sensing | Patients with heart failure (HF) have higher fasting insulin levels and a higher prevalence of insulin resistance as compared with matched controls. | 23575256 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjustment for covariates, we observed that hypertension, diabetes, chronic kidney disease and dyslipidemia were positively and significantly associated with aPWV. | 23575382 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | According to epidemiological studies, dyslipidaemia is the commonest risk factor of atherosclerosis in the Polish population. | 23575780 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol: a pilot study. | 23577182 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | Cortisol excess is known to cause insulin resistance, an independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their insulin resistance is secondary to the excess cortisol and therefore potentially reversible. | 23577182 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | Short-term GR antagonism is sufficient to reduce insulin resistance in some individuals with adrenal incidentalomas and mild cortisol excess. | 23577182 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The patients with CAD had a lower systolic blood pressure and heart rate, a lower incidence of diabetes, and greater incidence of dyslipidemia. | 23582626 |
| Fibrosis Assessment, Neoplasm Metastasis | Deregulated Nutrient Sensing | SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. | 23583181 |
| Fibrosis Assessment, Breast Carcinoma | Deregulated Nutrient Sensing | Reduced SIRT1 levels in HMLER breast cancer cells led to increased metastases in nude mice, and the loss of SIRT1 in kidney tubular epithelial cells exacerbated injury-induced kidney fibrosis. | 23583181 |
| Primary malignant neoplasm, Fibrosis Assessment | Deregulated Nutrient Sensing | SIRT1 reduces EMT in cancer and fibrosis by deacetylating Smad4 and repressing the effect of TGF-b signaling on MMP7, a Smad4 target gene. | 23583181 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome. | 23585246 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The VAI can replace visceral CT scanning as a marker for visceral adiposity, and it predicts insulin resistance in young women with PCOS. | 23585246 |
| Atherosclerosis | Deregulated Nutrient Sensing | Higher levels of AOPPs, AGEs, oxLDL, NOx, atherosclerosis risk markers, and insulin resistance were pointed out in IFG and T2DM groups compared with control. | 23587667 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The risk of AF recurrence in PAF patients increased in the presence of hypertension, dyslipidemia, large left atrial diameter (LAD) and low ejection fraction. | 23588029 |
| Weight decreased | Deregulated Nutrient Sensing | Insulin resistance may play a negative role in maintaining weight loss. | 23588462 |
| Refractory anemias, Rheumatoid Arthritis, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, a risk factor for cardiovascular diseases, is more prevalent in patients with rheumatoid arthritis (RA) than in the general population. | 23588940 |
| Refractory anemias, Dyslipidemias, Chronic inflammatory disorder | Deregulated Nutrient Sensing | These results provide the first evidence that genetic mechanisms linked to dyslipidemia may directly contribute to the susceptibility and prognosis of RA, a representative of chronic inflammatory diseases, explaining the high incidence of dyslipidemia in RA. | 23588940 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dietary n-3 long-chain PUFA (LC-PUFA) improve dyslipidaemia and hypertension and may affect insulin resistance and adiposity. | 23591057 |
| Obesity | Deregulated Nutrient Sensing | These associations remained after stratification for sex, traditional risk factors of CVD and insulin resistance, but were attenuated after taking a measure of obesity (body mass index) into account. | 23591414 |
| Hypertension, CTCAE, Haiti | Deregulated Nutrient Sensing | High sodium (HS) diet is associated with hypertension (HT) and insulin resistance (IR). | 23594269 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | Also, HS diet was associated with HT, insulin resistance, dyslipidaemia and hypoadiponectinaemia, even when adjusting by confounding variables. | 23594269 |
| Diabetic Nephropathy, Inflammation, Injury of kidney | Deregulated Nutrient Sensing | NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. | 23594678 |
| Diabetic Nephropathy, Inflammation, Injury of kidney | Deregulated Nutrient Sensing | Thus, NOD2 is one of the critical components of a signal transduction pathway that links renal injury to inflammation and podocyte insulin resistance in diabetic nephropathy. | 23594678 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Multivariate Logistic regression analysis showed that high blood glucose and abdominal obesity were significantly related to the prevalence of dyslipidemia, urine iodine concentration was no significant correlation with the prevalence of dyslipidemia. | 23596701 |
| Inflammation, Sleep Apnea Syndromes | Deregulated Nutrient Sensing | Sleep apnoea, sleepiness, inflammation and insulin resistance in middle-aged males and females. | 23598957 |
| Inflammation, Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | In obese males obstructive sleep apnoea (OSA) is associated with inflammation and insulin resistance; however, findings are confounded by adipose tissue, a hormone- and cytokine-secreting organ. | 23598957 |
| Inflammation, Osage language | Deregulated Nutrient Sensing | In conclusion, OSA is associated with sleepiness, inflammation and insulin resistance, even in nonobese males, and this association is stronger in males than in females. | 23598957 |
| Atherosclerosis | Deregulated Nutrient Sensing | Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. | 23599442 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relative contributions of insulin resistance and b-cell dysfunction to the development of Type 2 diabetes in Koreans. | 23600561 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Controversies still exist regarding the relative contributions of insulin resistance and b-cell dysfunction to the pathogenesis of Type 2 diabetes in different populations. | 23600561 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined the associations of baseline insulin resistance and b-cell function indices with the development of Type 2 diabetes in Koreans. | 23600561 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In individuals with low BMI, b-cell dysfunction is the predominant defect, whereas insulin resistance is the predominant pathogenetic factor in individuals with high BMI in the development of Type 2 diabetes in Koreans. | 23600561 |
| AHSG protein, human, Non-alcoholic Fatty Liver Disease, Arterial calcification | Deregulated Nutrient Sensing | Fetuin-A inhibits arterial calcification, induces insulin resistance, and is increased in NAFLD. | 23600632 |
| Arterial Stiffness, Cavia, Carotid Intima-Media Thickness, Diabetes Mellitus | Deregulated Nutrient Sensing | Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased arterial stiffness evaluated by means of carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI). | 23601500 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Erectile dysfunction, Renal Insufficiency, Hypertension, CTCAE, AIDS-Related Malignant Neoplasm | Deregulated Nutrient Sensing | The number of comorbidities increased with age and the same pattern was observed for the majority of the comorbidities, including diabetes mellitus, dyslipidemia, hypertension, cardiovascular diseases, erectile dysfunction, HCV, renal dysfunction and also for non-AIDS-related cancers (p<0.001). | 23602466 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Multivariable models were adjusted for age, smoking, cardiovascular disease, hypertension, diabetes, dyslipidaemia, body mass index and serum creatinine concentration. | 23602862 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Bone Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Vitamin D deficiency is a well-established risk factor for bone disease, but emerging data suggest that altered vitamin D homeostasis may play a role in the development of type 2 diabetes mellitus (T2DM), dyslipidemia hypertension, and other cardiovascular diseases (CVD). | 23607183 |
| Weight Gain, Diabetes Mellitus | Deregulated Nutrient Sensing | Whole grains may offer protection from diabetes by decreasing energy intake, preventing weight gain, and direct effects on insulin resistance. | 23608304 |
| Temporal Lobe, Disorder of renal parenchyma, Dyslipidemias | Deregulated Nutrient Sensing | To our knowledge, this is the first report of an unusual association between bilateral temporal lobe agenesis associated with renal parenchymal disease and dyslipidaemia. | 23612653 |
| Gastrointestinal carcinoma | Deregulated Nutrient Sensing | Parenteral nutrition and preOp preparation in prevention of post-operative insulin resistance in gastrointestinal carcinoma. | 23612677 |
| Malignant neoplasm of gastrointestinal tract | Deregulated Nutrient Sensing | The aim was to compare preventive effect of total parenteral nutrition (TPN) and oral nutrition (preOp) on the perioperative insulin resistance prevention in surgical gastrointestinal cancer patients. | 23612677 |
| millicurie, Impaired cognition, Data types - Address | Deregulated Nutrient Sensing | The present study evaluated the alterations in serum sirtuin1 (SIRT1) concentration in healthy individuals (young and old) and patients with AD and mild cognitive impairment (MCI). | 23613875 |
| Data types - Address | Deregulated Nutrient Sensing | A significant (p<0.0001) decline in SIRT1 concentration was observed in patients with AD (2.27 +- 0.46 ng/ul) and MCI (3.64 +- 0.15 ng/ul) compared to healthy elderly individuals (4.82 +- 0.4 ng/ul). | 23613875 |
| Dyslipidemias, Hyperglycemia, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Prolonged sitting is associated with increased weight and higher risks for abdominal obesity, dyslipidaemia, hyperglycaemia and hypertension among the adult population. | 23613917 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Participants with prediabetes have lower zinc levels than controls and zinc is significantly associated with beta cell function and insulin resistance. | 23613929 |
| palladium, Dyslipidemias | Deregulated Nutrient Sensing | After demographic adjustment, T2DM patients with PD showed a significantly lower HbA1c (58.0 vs. 60.3 mmol/mol; p < 0.0001), OAD/GLP-1 treatment (41.9 vs. 45.9%; p < 0.01) and frequency of dyslipidemia (62.0 vs. 64.5%; p < 0.05). | 23615668 |
| Hyperactive behavior, Neurodevelopmental Disorders | Deregulated Nutrient Sensing | Our findings demonstrate a mechanistic link between STRADA loss and mTORC1 hyperactivity in PMSE, and suggest that mTORC1 inhibition may be a potential treatment for PMSE as well as other mTOR-associated neurodevelopmental disorders. | 23616120 |
| Dyslipidemias | Deregulated Nutrient Sensing | Small, dense low-density lipoprotein (LDL) particles are highly atherogenic and strongly associated with obesity-related dyslipidemia. | 23616363 |
| Dyslipidemias | Deregulated Nutrient Sensing | Definitions of CVD risk vary and prevalence of dyslipidemia (abnormal total cholesterol, high-density lipoprotein (HDL-C), or non-HDL-C) among at-risk women may vary by age and definition of CVD risk. | 23621744 |
| acetohydroxamic acid, Dyslipidemias | Deregulated Nutrient Sensing | The AHA risk definition identified 45% more young women and 25% more older women than the USPSTF risk definition; however, both definitions of at-risk identified similar prevalence estimates of dyslipidemia among women. | 23621744 |
| Optic Disk, Dyslipidemias, Diabetes Mellitus, Retinal Vein Occlusion, Corneal diameter | Deregulated Nutrient Sensing | We found that PEX was not associated (all P>0.05) with sex, diabetes mellitus, blood pressure, psychological depression, smoking, dyslipidemia, body mass index, central corneal thickness, corneal diameter, optic nerve head measurements, choroidal thickness, retinal vessel diameters, early age-related macular degeneration, or retinal vein occlusion. | 23622877 |
| Glucose Intolerance (disease), Mitochondrial Diseases, Polyneuropathy, Alcoholic Intoxication, Chronic | Deregulated Nutrient Sensing | Previous reports have shown that this disease is associated with alcoholism, polyneuropathy, mitochondrial disease, and glucose intolerance. | 23623508 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | The comorbidities may include insulin resistance, type II diabetes mellitus, hypertension and cardiovascular disease. | 23624031 |
| metabolic disturbance | Deregulated Nutrient Sensing | Aging may also be associated with increased risk of insulin resistance and metabolic disturbances. | 23624031 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | The deterioration of insulin resistance during the reproductive life of women with PCOS appears to be mainly attributable to the increase in obesity. | 23624031 |
| metabolic disturbance | Deregulated Nutrient Sensing | Therefore, if body weight could be controlled properly, younger hyperandrogenic PCOS women might reduce their risk of insulin resistance and metabolic disturbances later in life. | 23624031 |
| Dyslipidemias, Ulcerative Colitis | Deregulated Nutrient Sensing | An intervention (IT) cohort of 213 patients referred for management of dyslipidemia by clinical pharmacists and a control cohort of 219 patients with dyslipidemia receiving usual care (UC). | 23625745 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Laboratory studies suggest that fine particulate matter (<= 2.5 um in diameter; PM(2.5)) can activate pathophysiological responses that may induce insulin resistance and type 2 diabetes. | 23632126 |
| Systolic Pressure | Deregulated Nutrient Sensing | Insulin resistance, total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, sum of two skinfolds and systolic blood pressure (SBP) z-scores were summed to compute a CVD risk score. | 23632753 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease. | 23633195 |
| Arterial Stiffness, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | We investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects. | 23633195 |
| Arterial Stiffness, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | A gender-based difference in circulating glypican-4 levels was apparent as these were increased in women with NAFLD and related to body fat distribution, insulin resistance, and arterial stiffness. | 23633195 |
| Thrombosis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is associated with tunneled-cuffed catheter-related central venous thrombosis in hemodialysis patients: a retrospective, multicenter study. | 23634689 |
| Vertical Talus, Dyslipidemias | Deregulated Nutrient Sensing | Patients with CVT had a higher prevalence of dyslipidemia (50.74 vs. 26.85%, respectively) and low protein store compared with the control group. | 23634689 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and low serum albumin levels were significantly associated with TCC-related CVT in hemodialysis patients. | 23634689 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Pioglitazone, an anti-diabetic agent that improves insulin resistance, was also reported to decrease inflammation and protect against atherosclerosis. | 23635096 |
| glycation, Diabetes Mellitus | Deregulated Nutrient Sensing | In diabetes, dietary advanced glycation end products (dAGEs) cause OS/Infl and suppress SIRT1. | 23636469 |
| Metabolic Diseases | Deregulated Nutrient Sensing | In conclusion, chronic consumption of high-AGE diets depletes defenses such as SIRT1 and PPARg, independent of calories, predisposing to OS/Infl and chronic metabolic disease. | 23636469 |
| Obesity | Deregulated Nutrient Sensing | Recently, the novel myokine irisin was described to drive adipose tissue 'browning', to increase energy expenditure, and to improve obesity and insulin resistance in high fat-fed mice. | 23637927 |
| Dyslipidemias, Disorder of the optic nerve | Deregulated Nutrient Sensing | In multivariate analysis, higher RNFL visibility score was associated with younger age (P<0.001; standardized coefficient beta: -0.44; regression coefficient B: -0.22; 95%CI: -0.24, -0.20), female gender (P<0.001; beta: 0.11; B: 1.00; 95%CI: 0.67, 1.32), higher blood concentration of low-density lipoproteins (P = 0.002; beta: 0.07; B: 0.34; 95%CI: 0.13, 0.56), absence of dyslipidemia (P = 0.001; beta: -0.07; B: -0.58; 95%CI: -0.93, -0.24), lower blood glucose concentration (P = 0.006; beta: -0.05; B: -0.14; 95%CI: -0.24, -0.04), hyperopic refractive error (P<0.001; beta: 0.15; B: 0.45; 95%CI: 0.34, 0.56), smaller optic disc size (P<0.001; beta: -0.08; B: -0.72; 95% CI: -1.04, -0.40), absence of glaucomatous optic neuropathy (P<0.001; beta: -0.06; B: -2.69; 95%CI: -4.18, -1.21) and absence of non-glaucomatous optic nerve damage (P = 0.001; beta: -0.06; B: -4.80; 95%CI: 0. | 23637954 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and diabetes are established risk factors for cardiovascular disease (CVD) morbidity and mortality. | 23638684 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Circulating adipocyte fatty acid-binding protein (FABP4) levels are considered to be a link between obesity, insulin resistance, diabetes, and cardiovascular (CV) diseases. | 23642261 |
| Dyslipidemias | Deregulated Nutrient Sensing | Despite available medications for dyslipidemia, many treated patients still have suboptimal lipid levels. | 23642513 |
| Dyslipidemias, ras GTPase-Activating Proteins | Deregulated Nutrient Sensing | In conclusion, despite widely available treatments for dyslipidemia, many patients remain at suboptimal lipid levels, indicating need for greater adherence to lifestyle and medical therapies to address these gaps in the management of dyslipidemia. | 23642513 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Multivariate logistic regression analysis showed that GA/AA was associated with an increased risk of hypertension in synergy with high insulin level and insulin resistance. | 23644116 |
| Dyslipidemias, Malignant Neoplasms, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Furthermore, both the genes harboring DMCs and the genes harboring DVCs showed significant enrichment of genes identified by genome-wide association studies on obesity and related diseases, such as hypertension, dyslipidemia, type 2 diabetes and certain types of cancers, supporting their roles in the etiology and pathogenesis of obesity. | 23644594 |
| Angina, Unstable, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Compared with the ST-elevation myocardial infarction subgroup, the unstable angina and non-ST-elevation myocardial infarction patients had higher frequencies of hypertension, diabetes, prior coronary heart disease (p<0.001) and dyslipidemia (p = 0.03). | 23644870 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cerebrovascular accident | Deregulated Nutrient Sensing | The prevalence of type 2 diabetes, hypertension and insulin resistance was higher in the group of patients with stroke. | 23645309 |
| Dyslipidemias, ETV3 wt Allele | Deregulated Nutrient Sensing | Lifestyle interventions for reducing PBF and controlling dyslipidemia could help reduce the risk of MetS in this population. | 23647841 |
| Myocardial, GDC AJCC Clinical Stage Terminology, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with ACS and without previously known diabetes, acute insulin resistance (HOMA index) is associated with a larger myocardial damage (ie, higher values of peak Tn I and lower LVEF) and a greater inflammatory activation (indicated by correlation with leukocyte count). | 23650645 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The influence of pre-natal conditions on later type 2 diabetes risk factors such as insulin resistance (IR) may be mediated by post-natal growth trajectory. | 23652936 |
| Aggressive course | Deregulated Nutrient Sensing | E2 potentiates miR-34a downregulation thus enhancing SIRT1 expression, depicting a novel eNOS/SIRT1 interplay fine-tuned by E2-activated ER signaling, and suggesting that eNOS may play an important role in aggressive PCa. | 23658738 |
| Hypercholesterolemia, Obesity, Abdominal, Hyperinsulinism, Hypertension, CTCAE | Deregulated Nutrient Sensing | Serum 25(OH)D levels were statistically lower in adolescents with weight excess, abdominal obesity, hypercholesterolaemia, higher levels of parathyroid hormone, insulin resistance, hyperinsulinaemia and hypertension (P < 0.05). | 23659537 |
| Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. | 23659870 |
| Acromegaly | Deregulated Nutrient Sensing | Insulin resistance improved when acromegaly was controlled with therapy with SSAs, PEG, or SSA+PEG. | 23660641 |
| Acromegaly | Deregulated Nutrient Sensing | Medical therapies for acromegaly reduce insulin resistance and increase insulin sensitivity; on the contrary, glucose indexes may be differently affected by SSA or PEG therapy. | 23660641 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Incidence of MI is increasing among hospital admissions in Ilorin and there is an urgent need for community interventions targeted at early detection and treatment of hypertension, diabetes mellitus, dyslipidaemia and obesity. | 23661202 |
| Irregular Menstruation, Oligomenorrhea, Hyperandrogenism | Deregulated Nutrient Sensing | Although menstrual irregularity is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with oligomenorrhoea (OM) is unclear. | 23663009 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In normal-weight women (BMI < 23 kg/m(2)), the degrees of insulin resistance and hyperandrogenaemia are the highest in PCOS and higher in severe OM compared with mild OM. | 23663009 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Asthma, Hypertension, CTCAE | Deregulated Nutrient Sensing | Overall, 19% of patients had comorbid asthma, 66% hypertension, 61% dyslipidemia, 30% cardiovascular disease, and 28% diabetes. | 23663130 |
| Acromegaly | Deregulated Nutrient Sensing | Improvement of insulin resistance following transsphenoidal surgery in patients with acromegaly: correlation with serum IGF-I levels. | 23665535 |
| Acromegaly | Deregulated Nutrient Sensing | In patients with acromegaly, serum IGF-I levels, but not GH levels, were significantly correlated with insulin resistance. | 23665535 |
| Glucose Intolerance (disease), Acromegaly | Deregulated Nutrient Sensing | The aim of this study was to determine the correlation between the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis and glucose intolerance in acromegaly during the early postoperative period. | 23665535 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Epidemiologic data suggest that non-alcoholic fatty liver disease (NAFLD) have an increased tendency to occur in patients who are associated with metabolic conditions such as obesity, type 2 diabetes mellitus, and dyslipidemia. | 23672077 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Comparison of pitavastatin with atorvastatin in increasing HDL-cholesterol and adiponectin in patients with dyslipidemia and coronary artery disease: the COMPACT-CAD study. | 23672789 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Metabolic factors linked with coagulation factors were hypertriglyceridaemia (tPA, P < 0.05; PAI-1, P < 0.05; protein C, P < 0.05) and insulin resistance (tPA, P < 0.01; PAI-1, P < 0.01; vWF, P < 0.05). | 23673438 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Vitamin D status has been implicated in insulin resistance, type 2 diabetes mellitus, and hypertension, but the range of vitamin D status values over which the association can be found is unknown. | 23674796 |
| HIV Infections | Deregulated Nutrient Sensing | We explored the relationship between vitamin D levels and insulin resistance (IR) among 1082 nondiabetic (754 HIV-infected) women enrolled in the Women's Interagency HIV study (WIHS), a large and well-established cohort of HIV infected and uninfected women in the US. | 23675750 |
| Hepatitis C | Deregulated Nutrient Sensing | Ethnicity, body mass index, smoking status, and hepatitis C status were independently associated with insulin resistance in HIV-infected and uninfected women. | 23675750 |
| Refractory anemias, Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | To investigate how cholesteryl ester transfer protein (CETP), one of the enzymes involved in the reverse cholesterol transfer, is expressed in patients with rheumatoid arthritis (RA) and its potential relationship with both dyslipidemia and the risk of cardiovascular mortality observed in these patients. | 23678159 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity and insulin resistance were also associated with a greater risk of elevated ALT. | 23678860 |
| Dyslipidemias, Serum LDL cholesterol measurement | Deregulated Nutrient Sensing | Apolipoprotein B showed the strongest tracking in both sexes, stronger than for LDL-cholesterol, which supports the importance of determining apo B levels as a marker of dyslipidaemia in children. | 23679859 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Similar trends were observed for hypertension in boys and insulin resistance for both genders. | 23680122 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pattern and predictors of dyslipidemia in patients with type 2 diabetes mellitus. | 23680249 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia is a major risk factor for macro-vascular complications in patients with type 2 diabetes mellitus (T2DM). | 23680249 |
| Dyslipidemias | Deregulated Nutrient Sensing | Present study explored pattern and predictors of dyslipidemia in Bangladeshi T2DM patients. | 23680249 |
| Dyslipidemias | Deregulated Nutrient Sensing | The characteristic features of diabetic dyslipidemia are low HDL, high triglyceride and LDL cholesterol level. | 23680249 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Poor glycemic control, prolonged duration, coexisting hypertension predicts dyslipidemia in T2DM. | 23680249 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku study. | 23680915 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Greater insulin resistance indicates decreased diurnal variation in the QT interval in patients with type 2 diabetes. | 23681273 |
| diabetic | Deregulated Nutrient Sensing | However, the relationship between QT prolongation and the degree of insulin resistance as well as circadian variation remains unclear in diabetic patients. | 23681273 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study was designed to assess the relationship between insulin resistance and the circadian variation in QT measurements in patients with type 2 diabetes. | 23681273 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Previous studies have shown that hs-CRP is associated with insulin resistance, type 2 diabetes and higher HbA1c levels. | 23682523 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Prevalence and risk factors of elevated blood pressure, overweight, and dyslipidemia in adolescent and young adults in rural Nepal. | 23682595 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Ethnic plains Madheshi were less likely to be overweight (0.3; 0.2-0.4), but had greater risk of dyslipidemia (1.4; 1.1-1.7) versus those of Hill origin. | 23682595 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Pharmacotherapy to manage hyperglycaemia, dyslipidaemia and hypertension was widely prescribed. | 23683111 |
| Dyslipidemias | Deregulated Nutrient Sensing | Amongst individuals with dyslipidaemia, median low-density lipoprotein cholesterol (LDL-C) was 1.8 mmol/l for those with T2DM and 2.8 mmol/l for those without. | 23683111 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Changes in the human gut microbiome are associated with type 2 diabetes and insulin resistance. | 23685372 |
| Dyslipidemias, Calcinosis | Deregulated Nutrient Sensing | The release of proatherogenic substances by the steatotic liver or its contribution to insulin resistance and dyslipidemia may contribute to the development of calcification and sclerosis of the aortic valve. | 23685558 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a common contributory cause of cardiovascular disease. | 23686894 |
| Glucose Intolerance (disease), Urinary tract infection, Pneumonia | Deregulated Nutrient Sensing | Glucose intolerance, urinary tract infections, and pneumonia were the major side effects observed in this study. | 23689577 |
| Steatohepatitis, Dyslipidemias | Deregulated Nutrient Sensing | However, increasing evidence now suggests that total body irradiation treatment, specifically, is linked with future risk of insulin resistance, hepatic steatosis and dyslipidaemia, possibly because total body irradiation affects adipocyte differentiation and impairs subcutaneous adipose tissue depot expansion during times of positive energy balance. | 23692373 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Previous studies have linked vitamin D deficiency to hypertension, dyslipidemia, diabetes mellitus, and cardiovascular disease. | 23694999 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Elevated plasma free fatty acids (FFAs) are one important link between excess visceral adiposity, insulin resistance, and the development of type 2 diabetes. | 23695818 |
| Hypertension, CTCAE, Endothelial dysfunction | Deregulated Nutrient Sensing | Reduced NO availability is associated with endothelial dysfunction, hypertension, insulin resistance and cardiovascular remodeling. | 23698802 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | BS/GS patients' mononuclear cell SIRT1 (western blot), FMD (B-mode scan of the right brachial artery) and heme oxygenase (HO)-1 (sandwich immunoassay), a potent antioxidant protein, were compared with the levels in untreated stage 1 essential hypertensive patients (HPs) and in healthy subjects (C). | 23698802 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Increased SIRT1 and its direct relationship with increased FMD in BS/GS patients, while strengthening the relationship among SIRT1, NO and vascular function in humans, point toward a role for reduced SIRT1 in the endothelial dysfunction of hypertension. | 23698802 |
| Overweight | Deregulated Nutrient Sensing | We evaluated 70 subjects distributed in 12 non-obese lean subjects, 23 overweight subjects, 12 obese subjects and 23 nondiabetic morbidly obese patients (11 with low insulin resistance and 12 with high insulin resistance). | 23700440 |
| Hyperglycemia, Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Obstructive sleep apnea syndrome (OSAS) may promote hyperglycemia and insulin resistance. | 23701956 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. | 23702379 |
| Adenocarcinoma, Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | We investigated SIRT1 and cortactin expression in 144 invasive non-small cell lung cancers (NSCLC) and 19 adenocarcinomas in situ (AIS) by immunohistochemistry and evaluated their clinicopathological significance in NSCLC. | 23702379 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Positive SIRT1 and cortactin expression was observed in 67% (96 of 144) and 58% (84 of 144) of patients with invasive NSCLC, respectively. | 23702379 |
| Adenocarcinoma, Neoplasm Metastasis, Neoplasms | Deregulated Nutrient Sensing | SIRT1 and cortactin expression was significantly associated with unfavorable clinicopathological factors, including high pathological T stage, lymph node metastasis, and advanced tumor invasion (AIS vs. invasive adenocarcinoma). | 23702379 |
| Neoplasm Metastasis, Neoplasms | Deregulated Nutrient Sensing | Cortactin was significantly associated with high pathological T stage and lymph node metastasis in SIRT1-positive tumors. | 23702379 |
| Neoplasms | Deregulated Nutrient Sensing | Cytoplasmic SIRT1 was significantly associated with high pathological T stage and large tumor size compared to that of nuclear SIRT1. | 23702379 |
| Neoplasm Metastasis, Neoplasms | Deregulated Nutrient Sensing | Large tumor size, high pathological T stage, lymph node metastasis, and cytoplasmic SIRT1 expression were significantly associated with shorter overall survival in a univariate analysis. | 23702379 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Our findings suggest that SIRT1 and cortactin may play a role in the progression of NSCLC and may cooperate during tumor progression in NSCLC. | 23702379 |
| Dyslipidemias, Diabetes Mellitus, Chronic disease, Asthma, Hypertension, CTCAE | Deregulated Nutrient Sensing | Chronic medical illness (mostly hypertension, dyslipidemia, asthma, and diabetes) was found in 82.4 %. | 23703373 |
| Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Hepatic steatosis and NAFLD were also independently associated with diabetes, with insulin resistance among people without diabetes, with dyslipidemia, and with obesity. | 23703888 |
| Ischemic stroke | Deregulated Nutrient Sensing | DHEAS may influence ischemic stroke risk through atherosclerotic-related mechanisms (endothelial function and smooth muscle cell proliferation) or insulin resistance. | 23704104 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Risk factors for type 2 diabetes mellitus preceded by b-cell dysfunction, insulin resistance, or both in older adults: the Cardiovascular Health Study. | 23707958 |
| Structure of beta Cell of islet, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) and pancreatic b-cell dysfunction lead to type 2 diabetes mellitus (DM). | 23707958 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | In vitro data revealed that metformin inhibited cancer cell growth, activated cAMP-inducible protein kinase (5'-AMP-activated protein kinase [AMPK]), and down-regulated p70S6K/pS6. | 23709654 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Despite the benign nature of NAFLD, efforts should be directed toward early diagnosis, intensive blood glucose and blood pressure control, and effective dyslipidemia correction. | 23716995 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The remission of the skin lesions soon after control of dyslipidemia and diabetes mellitus is not typical for the usual GGA, which has a chronic relapsing course and a poor response to treatment. | 23720988 |
| Hyperglycemia, Obesity | Deregulated Nutrient Sensing | The results suggest that even a moderate amount of dietary fiber intake may be beneficial for managing the fasting plasma glucose level concomitant with insulin resistance, body weight, and body mass index in Japanese men with mild hyperglycemia and visceral fat obesity. | 23725526 |
| No metabolic abnormalities | Deregulated Nutrient Sensing | In peritoneal dialysis, the high glucose load absorbed from dialysis fluid contributes to several metabolic abnormalities, including insulin resistance. | 23725973 |
| Fatty degeneration | Deregulated Nutrient Sensing | In animal models, OCA decreases insulin resistance and hepatic steatosis. | 23727264 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Ezetimibe/simvastatin 10/20 mg is comparable to atorvastatin 20 mg for the management of dyslipidemia, and may have more favorable effects on apolipoprotein profiles than atorvastatin 20 mg in Korean patients with type 2 diabetes mellitus. | 23728830 |
| Atrial Fibrillation, Dyslipidemias, Heart failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients who developed AF, with respect to those who did not, were older and more frequently with NSTEMI at admission (69.2 vs. 53.5%, p = 0.013), diabetes, dyslipidemia and history of heart failure. | 23729385 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Skeletal muscle structure | Deregulated Nutrient Sensing | Abdominal obesity, characterized by ectopic fat deposition in skeletal muscle and liver tissue, has been associated with insulin resistance and increased risk for type 2 diabetes mellitus. | 23731019 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance may be an independent risk factor for the development of hypertension, but change in blood pressure (BP) over time has not been adequately studied in healthy individuals fully characterized for insulin sensitivity. | 23734006 |
| AATF wt Allele, Dry Eye Syndromes, Dyslipidemias | Deregulated Nutrient Sensing | This study aimed to determine the relationship between dyslipidemia and dry eye disease (DED) in a Korean population. | 23734839 |
| AATF wt Allele, Dyslipidemias | Deregulated Nutrient Sensing | DED in a Korean population was found to be associated with high serum cholesterol levelsThe results of this study highlight the significance of eye examinations and independent lipid profile monitoring in patients with dyslipidemia because of its possible correlation with DED progression. | 23734839 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | In obese individuals with prediabetes or early untreated DM, Aloe QDM complex reduced body weight, BFM, and insulin resistance. | 23735317 |
| Decreased renal function, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance, incident cardiovascular diseases, and decreased kidney function among nondiabetic American Indians: the Strong Heart Study. | 23735722 |
| Obesity | Deregulated Nutrient Sensing | Prevalence of insulin resistance is high in the American Indian population, likely as a result of the high prevalence of obesity. | 23735722 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | Prospectively, insulin resistance is associated with the development of CVD and decreased kidney function in this population. | 23735722 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance may have an important role in the pathogenesis of CVD and chronic kidney disease. | 23735722 |
| Obesity | Deregulated Nutrient Sensing | Since obesity contributes to the development of insulin resistance, intervention focusing on modifiable factors such as physical activity and weight control may reduce the development of these diseases. | 23735722 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Total lipid management and cardiovascular disease in the dyslipidemia international study. | 23736147 |
| Abnormality, Dyslipidemias, Heart failure | Deregulated Nutrient Sensing | Overall, elevated LDL-C was the most frequent lipid anomaly observed, and preexisting heart failure was strongly and positively associated with dyslipidemia. | 23736147 |
| Inflammation, Cardiac complication, Obesity | Deregulated Nutrient Sensing | Childhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular complications later in life. | 23736361 |
| Obesity | Deregulated Nutrient Sensing | Second, the association between 25(OH)D deficiency and insulin resistance in childhood obesity was confirmed with multiple regression analysis. | 23736361 |
| Arterial Stiffness | Deregulated Nutrient Sensing | This study sought to determine the effect of Bikram yoga on arterial stiffness and insulin resistance in young and older adults. | 23738677 |
| Arterial Stiffness | Deregulated Nutrient Sensing | A relatively short-term Bikram yoga intervention improved arterial stiffness in young but not older adults and significantly reduced insulin resistance index in older but not young adults. | 23738677 |
| Data types - Address | Deregulated Nutrient Sensing | AD and MCI cybrids exhibited differences in proteins that monitor, respond to or regulate cell bioenergetic fluxes including HIF1a, PGC1a, SIRT1, AMPK, p38 MAPK and mTOR. | 23740939 |
| Increased insulin level, Glucose Intolerance (disease), Abnormality of mitochondrial metabolism, Hyperglycemia | Deregulated Nutrient Sensing | As a likely consequence of systemic mitochondrial dysfunction, Dync1h1 mutant mice develop hyperinsulinemia and hyperglycemia and progress to glucose intolerance with age. | 23742762 |
| Apolipoproteins B | Deregulated Nutrient Sensing | Plasma 25-hydroxyvitamin D was inversely associated with insulin, insulin resistance, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and the ratio of total to high-density lipoprotein cholesterol but not with fasting glucose, apolipoprotein A1, apolipoprotein B, C-reactive protein, fibrinogen, or homocysteine. | 23742939 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Notwithstanding improving rates of hypertension control in North America, management of patients with both hypertension and dyslipidemia remains problematic. | 23743804 |
| Obesity | Deregulated Nutrient Sensing | These adaptive processes might provide a valuable therapeutic target in the treatment of obesity and insulin resistance. | 23744406 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Insulin resistance and changes in body composition are side effects of androgen deprivation therapy (ADT) given to prostate cancer patients. | 23744766 |
| TG gene | Deregulated Nutrient Sensing | Seven days after surgery, significant reductions in the insulin resistance were observed, while TG and adiponectin levels remained unchanged during the meal test. | 23745620 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | In children with MetS, the prevalence of insulin resistance, high insulin, high non-HDL(high-density lipoprotein) cholesterol and high uric acid was higher than in children without MetS. | 23746346 |
| AHSG protein, human, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fetuin-A is an endogenous inhibitor of the insulin-stimulated insulin receptor tyrosine kinase recently shown that high levels of circulating fetuin-A are associated with insulin resistance in humans suggesting that fetuin-A may represent a novel mechanism involved in the pathophysiology of type 2 diabetes (T2DM). | 23748282 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Administration of beraprost significantly reduced patient-reported severity of lower limb ischemic symptoms in all patients at 12 months, including those with diabetes, hypertension, or dyslipidemia. | 23749750 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Decreases in IMT were similar in patients with diabetes, hypertension, or dyslipidemia. | 23749750 |
| Dyslipidemias, Cardiovascular Physiological Phenomena, Hyperuricemia, Diabetes Mellitus | Deregulated Nutrient Sensing | The decrease in age-adjusted CSE levels is a potential indicator of eventual cardiovascular dysfunction in medical check-up individuals, as predicted by the risk factors dyslipidemia, hyperuricemia or diabetes. | 23756406 |
| Dyslipidemias, Retinal Diseases | Deregulated Nutrient Sensing | Dyslipidemia and lipid peroxidation of Saudi type 2 diabetics with proliferative retinopathy. | 23756927 |
| Diabetic Retinopathy, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and lipid peroxidation may play a role in pathogenesis of diabetic retinopathy. | 23756927 |
| Hyperglycemia | Deregulated Nutrient Sensing | Surgical stress creates a state of insulin resistance which may contribute to the development of hyperglycemia and, subsequently, postoperative complications. | 23757474 |
| Inflammation | Deregulated Nutrient Sensing | Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study. | 23758216 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our findings suggest that increased magnesium intake was a significant protective factor for the incidence of Type 2 diabetes in the general Japanese population, especially among subjects with insulin resistance, low-grade inflammation and a drinking habit. | 23758216 |
| Apolipoproteins B, Dyslipidemias | Deregulated Nutrient Sensing | Treatment with glucomannan of children affected by primary dyslipidemia is well-tolerated and effectively lowers total and LDL cholesterol in females and non-high-density lipoprotein cholesterol, but not Apolipoprotein B in both males and females. | 23759268 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Primary dyslipidemias are major risk factors for cardiovascular disease and should be addressed early in life. | 23759268 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Because serum concentrations of soluble forms of TNF-like weak inducer of apoptosis (sTWEAK) and scavenger receptor CD163 (sCD163) have been associated with insulin resistance and type 2 diabetes mellitus (T2D), we tested the associations of sTWEAK and sCD163 with the future development of T2D in elderly subjects at high cardiovascular risk. | 23760626 |
| Insulitis | Deregulated Nutrient Sensing | In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic b -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to b -cell destruction, seems to be the triggering alteration. | 23762872 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Among 1950 women, elevated depressive symptoms were significantly associated with increased insulin levels and measures of insulin resistance. | 23763394 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The most common risk factors were hypertension and dyslipidemia in both groups. | 23764362 |
| Non-insulin Hypoglycemic, Obesity | Deregulated Nutrient Sensing | Among children with higher RBP4, the association with obesity increased significantly (from 3.1 to 8.5) in the presence of insulin resistance, when compared to higher RBP4 and non-insulin resistance. | 23764679 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Study consisted of subjects attending the gynecological clinic of Siena or Pisa, with PCOS and insulin resistance, and without contraindications for the use of COCs. | 23769016 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, low SES was linked to increased prevalence and risks of dyslipidemia (P for trend<0.05) and parameters of dyslipidemia in women. | 23769897 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | These disparities should be considered when performing risk calculations and screening for dyslipidemia, which will ultimately help prevent cardiovascular disease. | 23769897 |
| Carcinoma of anal canal, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Hypothyroidism, Rheumatoid Arthritis, Obesity, Overweight | Deregulated Nutrient Sensing | Associated pathology was diabetes mellitus type II (five cases), overweight and obesity (five cases), dyslipidemia (three cases), hypothyroidism (one case), rheumatoid arthritis (one case), external ear canal basal carcinoma (one case). | 23771077 |
| Dyslipidemias, GAD1 gene, Diabetes Mellitus | Deregulated Nutrient Sensing | GAD is often associated with diabetes and dyslipidemia, therefore it is necessary to investigate patients in this direction. | 23771077 |
| Hyperglycemia, Illness (finding) | Deregulated Nutrient Sensing | The aim of this trial was to evaluate a subcutaneous insulin algorithm, which incorporates insulin resistance due to individual features and acute illness, for correction of hyperglycaemia in general medical wards. | 23771784 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertension, dyslipidemia and cardiovascular diseases were significantly more in the patients with abdominal obesity. | 23773268 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | BMI was significantly higher in patients with CAD (27.7 +- 4.3 vs 26.8 +- 4.3 kg/m(2), p < 0.001); these patients were also older, more often male and had higher prevalence of diabetes, hypertension and dyslipidemia. | 23774273 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Recent research has emphasized the strong association between inflammation and both P-wave dispersion and dyslipidemia. | 23778479 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It is more prevalent with increasing age, in males, in those who smoke, in those with diabetes, and in those with dyslipidaemia. | 23781540 |
| mecarzole, Dyslipidemias | Deregulated Nutrient Sensing | Clinically significant HTG in MBC patients treated with CAP may be associated with pre-existing risk factors, such as dyslipidemia or diabetes-mellitus. | 23783143 |
| KANTR gene, Dyslipidemias | Deregulated Nutrient Sensing | Patients with moderately/severe spasm were more frequently females, had a history of dyslipidemia, received more often a 7F sheath and more puncture attempts than patients without spasm. | 23785005 |
| Dyslipidemias, Breast Carcinoma | Deregulated Nutrient Sensing | Dyslipidaemia can affect cell integrity in patients of breast cancer. | 23785924 |
| Diabetes Mellitus, Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | [Atherogenic dyslipidemia in patients with type 1 diabetes mellitus]. | 23790581 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Microbial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction. | 23797689 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | It is hypothesized that microbial translocation may be related to dyslipidemia, insulin resistance, and the risk of coronary heart disease in HIV-infected individuals. | 23797689 |
| Cardiac complication, Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Hence, the gastrointestinal mucosal barrier may be a potential therapeutic target to prevent dyslipidemia and future cardiovascular complications in HIV infection. | 23797689 |
| Neoplasms | Deregulated Nutrient Sensing | Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model. | 23799088 |
| polyps | Deregulated Nutrient Sensing | We crossed APC(+/min) mice with mice bearing enterocyte-specific inactivation of SIRT1 and examined polyp development in the progeny. | 23799088 |
| Neoplasms | Deregulated Nutrient Sensing | Additionally, tumors in SIRT1-deficient mice exhibited markedly increased numbers of cells undergoing apoptosis, suggesting that SIRT1 contributes to tumor growth by enabling survival of tumor cells. | 23799088 |
| Neoplasms | Deregulated Nutrient Sensing | Our results indicate that SIRT1 acts as a tumor promoter in the APC(+/min) mouse model of intestinal tumorigenesis. | 23799088 |
| Communicable Diseases, Hepatitis C, Atherosclerosis | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) infection has been linked to an increased risk of insulin resistance and carotid atherosclerosis. | 23802888 |
| Venous Thromboembolism | Deregulated Nutrient Sensing | Body mass index, a major confounder to insulin resistance association with unprovoked venous thromboembolism. | 23803721 |
| vinyltriethoxysilane | Deregulated Nutrient Sensing | The potential association between insulin resistance and VTE has been poorly evaluated. | 23803721 |
| vinyltriethoxysilane | Deregulated Nutrient Sensing | Thus, we aimed to assess the association between insulin resistance and VTE in the EDITH hospital-based case-control study. | 23803721 |
| Inflammation, Obesity, Abdominal | Deregulated Nutrient Sensing | This dysfunction was best predicted by abdominal obesity, inflammation, glucose-intolerance, and systolic dyssynchrony. | 23804526 |
| Nerve Degeneration | Deregulated Nutrient Sensing | Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. | 23804751 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Here we investigated the effects of physical activity level on aging-associated insulin resistance in myotubes derived from human skeletal muscle satellite cells. | 23805253 |
| Hypopharyngeal Carcinoma | Deregulated Nutrient Sensing | The Expression of SIRT1 and DBC1 in Laryngeal and Hypopharyngeal Carcinomas. | 23805287 |
| Neoplasms | Deregulated Nutrient Sensing | Sirtuin 1 (SIRT1) plays an important role in tumorigenesis and is increased in many human tumors. | 23805287 |
| Hypopharyngeal Squamous Cell Carcinoma | Deregulated Nutrient Sensing | It is necessary to investigate the expression of SIRT1 and DBC1 in laryngeal and hypopharyngeal squamous cell carcinomas (LSCC and HSCC) and its correlation with available clinical parameters. | 23805287 |
| Neoplasms | Deregulated Nutrient Sensing | qRT-PCR assay showed that, compared with the paired adjacent noncancerous mucosae, SIRT1 mRNA was significantly decreased in tumors. | 23805287 |
| Neoplasms | Deregulated Nutrient Sensing | The immunohistochemical results indicated that the SIRT1 protein was also downregulated in tumors compared with noncancerous mucosae. | 23805287 |
| Neoplasm Metastasis, Neoplasms | Deregulated Nutrient Sensing | Moreover, decreased SIRT1 was significantly correlated with the tumor clinical stage and lymph node metastasis. | 23805287 |
| Hypopharyngeal Squamous Cell Carcinoma, Neoplasm Metastasis | Deregulated Nutrient Sensing | SIRT1 and DBC1 might be involved in the pathophysiology of laryngeal and hypopharyngeal squamous cell carcinomas and are associated with lymph node metastasis and p53 positive staining in LSCCs and HSCCs. | 23805287 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | With the increase of BMI, the odds ratios (ORs) of high TG, high TC, low HDL-c, high LDL-c and dyslipidemia showed a rising trend (P<0.05), and with the increase of WC, the ORs of high TG, high TC, high LDL-c and dyslipidemia showed a rising trend (P<0.05). | 23805507 |
| Dyslipidemias | Deregulated Nutrient Sensing | BMI and WC were independently associated with blood lipids levels, and high BMI and WC were the risk factors for dyslipidemia. | 23805507 |
| Dyslipidemias | Deregulated Nutrient Sensing | Compared with the contrast group, the risk of dyslipidemia significantly increased with increasing average daily alcohol consumption, while ORs were 1. | 23805522 |
| Dyslipidemias | Deregulated Nutrient Sensing | Alcohol consumption may be a risk factor of dyslipidemia in middle-aged men. | 23805522 |
| Dyslipidemias, Acromegaly | Deregulated Nutrient Sensing | Smoking (P = 0.007), increased HbA1c levels (P = 0.021), dyslipidaemia (P = 0.049), acromegaly control (P = 0.057), and folate-MTHFR genotype interaction (P = 0.088) were associated with CRT at multivariate analysis. | 23807201 |
| Dyslipidemias | Deregulated Nutrient Sensing | Smoking, high HbA1c levels, dyslipidaemia and disease activity were also associated with increased CRT risk. | 23807201 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | [The detection of leptin and metabolic markers of insulin resistance in patients with myocardial infarction]. | 23808002 |
| Hyperleucinemia, Hyperglycemia, Metabolic Diseases, Myocardial Infarction | Deregulated Nutrient Sensing | The identified hyperleptinemia, its relationship with basal and post-prandial hyperglycemia and with increase of C-peptide concentration and free fatty acids made possible to consider leptin both as one of the important components in the series of carbohydrate and lipid metabolism disorders and the additional marker of development of insulin resistance under cardiac infarction. | 23808002 |
| Coronary Artery Disease, atherosclerotic | Deregulated Nutrient Sensing | Insulin resistance negatively affects long-term outcome in non-diabetic patients with coronary artery disease after therapies to reduce atherosclerotic risk factors. | 23810069 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance (IR) is a predictor of cardiovascular (CV) events even before the onset of diabetes. | 23810069 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Comorbidities included dyslipidemia in 129 patients (64.5%) and diabetes in 54 patients (27%). | 23810299 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Individually, diabetes mellitus, hypertension, and dyslipidemia have been shown to increase the risk of cardiovascular disease. | 23810406 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | While traditional management of Type 2 diabetes has focused mainly on glycemic control, robust evidence supports the integration of hypertension and dyslipidemia management to reduce the risk of cardiovascular disease. | 23810406 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Seventy-two percent reported comorbid hypertension, dyslipidemia, or both. | 23810406 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with concurrent type 2 diabetes, hypertension, and dyslipidemia were 6 times more likely to report a prior history of cardiovascular disease compared with those with type 2 diabetes alone. | 23810406 |
| Diabetic Angiopathies, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes. | 23811603 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most frequently encountered comorbidities were hypertension (66%), followed by diabetes mellitus (50%) and dyslipidemia (38%). | 23814777 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Higher BHB values were independently associated with longer fasting and hyperglycemia, whereas lower values were associated with dyslipidemia and diabetes. | 23815820 |
| Hypertensive (finding), Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | In hypertensive patients with moderate dyslipidemia, pravastatin was not superior to usual care in preventing total mortality or CHD independent of baseline eGFR level. | 23816477 |
| Glucose Intolerance (disease), Heart failure, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Adiponectin levels are inversely correlated to progressing CHD and glucose intolerance but positively correlated to increasing heart failure. | 23818456 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Atherogenic dyslipidaemia was more strongly associated with the development of Type 2 diabetes than conventional lipid measurements, and this effect was independent of other well-established risk factor for diabetes. | 23819613 |
| Hepatitis A, Chronic liver disease | Deregulated Nutrient Sensing | Insulin resistance is associated with DNA damage in peripheral blood cells in non-diabetic patients with genotype 1 chronic hepatitis C. In chronic liver diseases of different etiologies, including viral hepatitis, genotoxic effects of oxidative stress have been shown, both in clinical and in experimental conditions, suggesting that this mechanism may contribute to the evolution of the disease. | 23822095 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Essential hypertension (EH) is often accompanied by hyperinsulinemia/insulin resistance (IR) and deranged adiponectin secretion. | 23822941 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | The 2009 guidelines for the diagnosis and treatment of dyslipidemia were used to define low, moderate or high cardiovascular disease (CVD) risk and treatment initiation and targets. | 23823891 |
| Dyslipidemias | Deregulated Nutrient Sensing | There is still a high proportion of Canadians at high risk of CVD, with dyslipidemia, who are not being treated to recommended levels. | 23823891 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Among rural and urban settings, 679 patients under continuous care (236 diabetics, 218 with dyslipidaemia, and 225 with hypertension) were consecutively selected by 20 experienced general practitioners. | 23824265 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It was greater among patients with hypertension and dyslipidaemia and smaller in diabetes care. | 23824265 |
| Congenital MeSH qualifier, Bartter Disease | Deregulated Nutrient Sensing | Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR? | 23824322 |
| Rabson-Mendenhall Syndrome, RMS, Congenital Rubella Syndrome | Deregulated Nutrient Sensing | Biallelic insulin receptor (INSR) gene mutations cause congenital syndromes of severe insulin resistance (SIR) known as Donohue syndrome (DS) and Rabson-Mendenhall syndrome (RMS). | 23824322 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | As insulin resistance (IR) is an established risk factor for colorectal cancer (CRC), we explored the association between each of the IR-related gene polymorphisms of adiponectin (ADIPOQ) rs2241766, uncoupling protein 2 (UCP2) rs659366, and fatty acid-binding protein (FABP2) rs1799883 and CRC risk. | 23826253 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Thus we reasoned that dyslipidemia-associated nucleotide polymorphisms (SNPs) on the APOA1/C3/A5 gene cluster may predict breast cancer risk and tumor progression. | 23829168 |
| Inflammation | Deregulated Nutrient Sensing | Adipocyte fatty acid-binding protein (A-FABP) plays a key role in obesity-related insulin resistance and inflammation which may be involved in the pathogenesis of sarcopenic obesity (SO). | 23830287 |
| Metastatic castration-resistant prostate cancer | Deregulated Nutrient Sensing | Temsirolimus blocks mammalian target of rapamycin (mTOR)/target of rapamycin complex 1 (TORC1), a key signaling node in this pathway; its activity in men with advanced castration-resistant metastatic prostate cancer (mCRPC) is unknown. | 23830964 |
| Demographics Domain, Osage language, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The baseline factors significantly associated with an increased risk for new-onset hypertension were male gender, obesity, diabetes mellitus (DM), dyslipidemia, and OSA. | 23831239 |
| Inflammation, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Weight decreased, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim was to evaluate the ability of liraglutide to augment weight loss and improve insulin resistance, cardiovascular disease (CVD) risk factors, and inflammation in a high-risk population for type 2 diabetes (T2DM) and CVD. | 23835684 |
| Weight decreased, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | The addition of liraglutide to calorie restriction significantly augmented weight loss and improved insulin resistance, systolic blood pressure, glucose, and triglyceride concentration in this population at high risk for development of T2DM and CVD. | 23835684 |
| Inflammation | Deregulated Nutrient Sensing | Models were adjusted for demographics, traditional risk factors, inflammation, insulin resistance and health behaviors. | 23835937 |
| Deficit, Impaired cognition | Deregulated Nutrient Sensing | T2DM is associated with cognitive impairment and neural deficits, because of insulin resistance and high expression of insulin receptors in the hippocampus. | 23835985 |
| Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although insulin resistance is usually associated with the development of type 2 diabetes, it can also be a feature of patients with type 1 diabetes. | 23837272 |
| Diabetes Mellitus, Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance has been documented in type 1 diabetes and may contribute to the high risk of cardiovascular disease in this population. | 23837272 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. | 23837842 |
| Diabetes Mellitus, Non-Insulin-Dependent, Immune System Diseases | Deregulated Nutrient Sensing | The prevalence of type 2 diabetes (T2D) is increasing worldwide and creating a significant burden on health systems, highlighting the need for the development of innovative therapeutic approaches to overcome immune dysfunction, which is likely a key factor in the development of insulin resistance in T2D. | 23837842 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | Impaired mitochondrial b-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance. | 23841691 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiovascular risk factors (CVRFs) includes hypertension, dyslipidemia, diabetes, overweight and smoking. | 23844099 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Psychological insulin resistance in type 2 diabetes patients regarding oral antidiabetes treatment, subcutaneous insulin injections, or inhaled insulin. | 23844571 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | "Psychological insulin resistance" (PIR) is an obstacle to insulin treatment in type 2 diabetes, and patients' expectations regarding alternative ways of insulin delivery are poorly understood. | 23844571 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Lipid accumulation product and insulin resistance in Iranian PCOS prevalence study. | 23844634 |
| Inflammation, Dyslipidemias, Lower Urinary Tract Symptoms | Deregulated Nutrient Sensing | Dyslipidemia and chronic inflammation may play a role in the cause of lower urinary tract symptoms (LUTS) in older men. | 23847173 |
| Hyperglycemia, Pancreatic carcinoma | Deregulated Nutrient Sensing | Hyperglycemia, insulin resistance, impaired pancreatic b-cell function, and risk of pancreatic cancer. | 23847240 |
| Hyperglycemia, Structure of beta Cell of islet | Deregulated Nutrient Sensing | These associations may be secondary to consequences of peripheral insulin resistance, pancreatic b-cell dysfunction, or hyperglycemia itself. | 23847240 |
| Hyperglycemia, Structure of beta Cell of islet | Deregulated Nutrient Sensing | Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsulin to insulin ratio marks pancreatic b-cell dysfunction. | 23847240 |
| Hyperglycemia, Structure of beta Cell of islet, Pancreatic carcinoma | Deregulated Nutrient Sensing | Among participants from five large prospective cohorts, circulating markers of peripheral insulin resistance, rather than hyperglycemia or pancreatic b-cell dysfunction, were independently associated with pancreatic cancer risk. | 23847240 |
| Cardiovascular Diseases, Sleep Apnea Syndromes, Malignant Neoplasms, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity in childhood is associated with a significant number of complications, such as sleep apnea syndrome, insulin resistance and type 2 diabetes, hypertension, cardiovascular disease and some cancers. | 23848092 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia plays an important role in the provocation of cardiovascular disease. | 23848231 |
| Lipodystrophy, Werner Syndrome | Deregulated Nutrient Sensing | Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome. | 23849162 |
| Lipodystrophy, Werner Syndrome | Deregulated Nutrient Sensing | We show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase. | 23849162 |
| Increased insulin level | Deregulated Nutrient Sensing | Their oral glucose tolerance tests showed extremely high levels of insulinemia, revealing major insulin resistance. | 23849162 |
| Ovarian Hyperandrogenism | Deregulated Nutrient Sensing | Insulin-resistance linked ovarian hyperandrogenism could also contribute to decreased fertility, and the two patients became pregnant after initiation of insulin-sensitizers (metformin). | 23849162 |
| Lipodystrophy, Premature aging syndrome | Deregulated Nutrient Sensing | We show here for the first time that partial lipodystrophy with severe insulin resistance can reveal WRN-linked premature aging syndrome. | 23849162 |
| Congenital Abnormality | Deregulated Nutrient Sensing | Since excess weight, glucose abnormalities, and insulin resistance tend to cluster, the individual role insulin resistance may have in habitual shortened sleep is unclear. | 23849514 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | There appears to be an independent association between habitual shortened sleep and insulin resistance among obese, dysglycemic adults without diabetes. | 23849514 |
| Chronic heart failure | Deregulated Nutrient Sensing | Effect of High-Intensity interval training versus moderate continuous training on 24-h blood pressure profile and insulin resistance in patients with chronic heart failure. | 23857036 |
| Heparin-induced thrombocytopenia | Deregulated Nutrient Sensing | HIT was more effective in improving insulin resistance. | 23857036 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | ACh-positive patients were more likely to be older male smokers with dyslipidemia, to have a family history of ischemic heart disease, and to have a comorbidity of coronary epicardial stenosis than were ACh-negative patients. | 23858100 |
| Dyslipidemias | Deregulated Nutrient Sensing | Age and dyslipidemia (or lipid profile) were associated with both ICAD and ECAD. | 23859180 |
| Old age | Deregulated Nutrient Sensing | SIRT1 exerts a protective effect against vascular senescence. | 23859249 |
| diabetic | Deregulated Nutrient Sensing | In streptozotocin-induced diabetic mice, administration of the G. gnemon ethanolic extract increased SIRT1 and decreased endothelial senescence. | 23859249 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer. | 23860205 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Continuous rise of insulin resistance before and after the onset of puberty in children at increased risk for type 1 diabetes - a cross-sectional analysis. | 23861173 |
| Diabetes Mellitus, Insulin-Dependent, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Deregulated Nutrient Sensing | Insulin resistance has been postulated to be linked to the frequent onset of type 1 diabetes (T1D) during puberty. | 23861173 |
| Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Deregulated Nutrient Sensing | To address the question of how insulin resistance develops with age and how this is related to puberty onset, we examined insulin resistance and pubertal development over time in children at increased risk for T1D. | 23861173 |
| Autoimmune Diseases, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Deregulated Nutrient Sensing | There was a constant age-dependent rise of insulin resistance during childhood without observed associations to the onset of puberty or the presence of islet autoimmunity in children at increased risk for T1D. | 23861173 |
| Hyperglycemia | Deregulated Nutrient Sensing | Complex pathophysiological mechanisms associated with insulin resistance and hyperglycemia are involved in the deleterious effects on osteoblast function and bone formation. | 23864319 |
| Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The use of antipsychotics can lead to the development of obesity, dyslipidemia, hypertension and hyperglycemia, risk factors for diabetes mellitus type 2 and cardiovascular diseases. | 23864411 |
| Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Regarding NCDs, their prevalence of hypertension was 32.8 %, diabetes 11.4 %, dyslipidemia 16.4 %, overweight 51.1 %, obesity 25.7 % and abdominal obesity 57.8 %. | 23864429 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Liver Cirrhosis | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. | 23864802 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | D-002 (100 mg/day) improved ultrasonographic findings, indicators of insulin resistance, plasma TAS and clinical evolution on NAFLD patients. | 23864802 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Sex, dyslipidemia, smoking and exercise habits were risk factors for CHD alone. | 23865387 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The risk of CHD in dyslipidemic patients on statin treatment was comparable to the risk in patients without dyslipidemia (HR = 1.134, 95% CI 0.604-2.126). | 23865387 |
| Dyslipidemias, Hypertension, CTCAE, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | These results suggest the importance of managing dyslipidemia with a statin for primary prevention of CHD, as well as the importance of hypertension therapy. | 23865387 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a common complication in patients with diabetes and is involved in being prone to cardiovascular disease. | 23866006 |
| Cardiovascular Diseases, Dyslipidemias, Hyperuricemia, Hua , Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperuricemia (HUA) is a potential risk factor for developing insulin resistance, hypertension, dyslipidemia and cardiovascular disease. | 23866159 |
| Microvascular Angina, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia and smoking were the most common identifiable risk factors for coronary vascular disease. | 23866534 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Some previous observations suggest that insulin resistance and glucose metabolism disturbances are frequent complications of chronic kidney disease. | 23867834 |
| HD Term Type | Deregulated Nutrient Sensing | HOMA beta-cell function is strongly correlated with HOMA insulin resistance in HD patients. | 23867834 |
| Bradyarrhythmia (disorder), Dyslipidemias, Osage language | Deregulated Nutrient Sensing | A multivariable logistic regression analysis demonstrated that dyslipidemia had the strongest association with a high risk for OSA, but not bradyarrhythmias. | 23867909 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Resolution of diabetes and dyslipidemia was seen in 85 and 50 % of patients, respectively. | 23868141 |
| Acute myocardial infarction, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance is associated with significant clinical atherosclerosis in nondiabetic patients with acute myocardial infarction. | 23868937 |
| Obesity | Deregulated Nutrient Sensing | The prevalence of insulin resistance (IR) is increasing worldwide because of increasing age, obesity, and physical inactivity. | 23868937 |
| Postoperative Period | Deregulated Nutrient Sensing | Use of high-dose remifentanil as intraoperative analgesia during elective gastrectomy reduced postoperative insulin resistance, although it did not reduce postoperative muscle protein catabolism. | 23869185 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Among a number of proposed innovative approaches targeting novel pathomechanisms, probiotics appear an interesting and reasonable option acting on gut-liver axis malfunction through the modulation of diet-driven, obesogenic, and inflammatory intestinal microbiota.A combined multiple pharmacological therapy directed simultaneously towards novel and old pathomechanisms (including, e.g., insulin resistance, oxidative stress, gut-liver axis, apoptosis) along with lifestyle interventions however might be necessary both in adult and pediatric NAFLD therapy. | 23870449 |
| Asp snake | Deregulated Nutrient Sensing | We demonstrate elevated mTOR complex 1 (mTORC1) activity in ASPS independent of mTOR complex 2 (mTORC2) activation. | 23871289 |
| Hyperglycemia, Obesity, Abdominal | Deregulated Nutrient Sensing | Older people with central obesity, hyperglycemia, insulin resistance and severe antioxidant status tended to have shorter telomere length. | 23873360 |
| Failure (biologic function) | Deregulated Nutrient Sensing | In AAs, high LF was associated with a 49% lower SI (P < .001), was not associated with an increase in AIR (P = .25), and was associated with a 42% lower DI (P < .01), indicating failure of compensatory insulin secretion/clearance in response to insulin resistance. | 23873990 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The age-and gender-standardized prevalence of diabetes mellitus and glucose intolerance were 7.1% (3.6% for undiagnosed) and 8.8% in adults aged >= 25 years, respectively, and increasing with age. | 23874667 |
| Glucose Intolerance (disease), Smoking, Diabetes Mellitus | Deregulated Nutrient Sensing | Smoking had a protective effect for diabetes, drinking had a positive association with diabetes mellitus and glucose intolerance. | 23874667 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus and glucose intolerance are common in rural adults of southwest China by international standards. | 23874667 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Among adults, skipping meals is associated with excess body weight, hypertension, insulin resistance, and elevated fasting lipid concentrations. | 23877060 |
| Sleep Apnea, Obstructive, Demographics Domain, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Current evidence supports an association between Obstructive Sleep Apnea Syndrome (OSAS), insulin resistance, type 2 diabetes mellitus (DM) and cardiovascular disorders. | 23877859 |
| Increased insulin level, Inflammation, Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | The mechanisms through which diabetes is assumed to promote oncogenesis include insulin resistance and associated hyperinsulinemia, hyperglycemia, and inflammation. | 23879470 |
| Dyslipidemias | Deregulated Nutrient Sensing | The egg-eating category was inversely associated with dyslipidemia (p < 0.05) but not with the other cardiovascular risk factors. | 23880191 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study. | 23880198 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | The relative importance of insulin resistance and hyperglycemia to the development of atherosclerosis remains unclear. | 23880198 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | Our aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis. | 23880198 |
| Hyperglycemia, Atherosclerosis | Deregulated Nutrient Sensing | In middle-aged individuals, we observed similar contributions of insulin resistance and hyperglycemia to subclinical atherosclerosis. | 23880198 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Hypothyroidism | Deregulated Nutrient Sensing | The most common comorbidities found in our population were hypertension (35%), diabetes mellitus (20%), hypothyroidism (7%) and dyslipidemia (7%). | 23882973 |
| STK11 protein, human, Biomechanics | Deregulated Nutrient Sensing | Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. | 23883619 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | AMPK activity is decreased in human knee osteoarthritis (OA) chondrocytes. | 23883619 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Both LKB1 and AMPK activity were decreased in mouse knee OA and aged knee cartilage, and in bovine chondrocytes after biomechanical injury. | 23883619 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Concurrent loss of LKB1 and AMPK activity in articular chondrocytes is associated with OA, aging and biomechanical injury. | 23883619 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Conversely, pharmacologic AMPK activation attenuates catabolic responses to biomechanical injury, suggesting a potentially novel approach to inhibit OA development and progression. | 23883619 |
| Atherosclerosis | Deregulated Nutrient Sensing | Longitudinal decline of b-cell function: comparison of a direct method vs a fasting surrogate measure: the Insulin Resistance Atherosclerosis Study. | 23884776 |
| Atherosclerosis | Deregulated Nutrient Sensing | The Insulin Resistance Atherosclerosis Study is a multicenter, observational, epidemiologic study. | 23884776 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Role of insulin resistance and adipocytokines on serum alanine aminotransferase in obese patients with type 2 diabetes mellitus. | 23884827 |
| Hypertransaminasaemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim of our study was to study the association of insulin resistance expressed by HOMA and adipokines in obese type 2 diabetic patients with or without hyper-transaminasemia. | 23884827 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Forty-two metabolites from three major fuel sources (carbohydrates, lipids, and proteins) were found to significantly correlate with T2D after adjusting for multiple testing; of these, 22 were previously reported as associated with T2D or insulin resistance. | 23884885 |
| Cardiovascular Diseases, Atherosclerosis, Cerebrovascular accident, Weight Gain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In addition, both weight gain and aging can lead to similar clinical outcomes such as insulin resistance, cardiovascular disease, type 2 diabetes mellitus, atherosclerosis and stroke. | 23886751 |
| Hypertension, CTCAE, Dysglycemia, Dyslipidemias | Deregulated Nutrient Sensing | On multiple linear regression analysis, elevated serum FGF21 level in women was an independent risk factor for increased carotid IMT (P=0.039), together with age (P<0.001) and hypertension (P=0.011), in a model comprising also waist circumference, smoking history, serum creatinine, high sensitive C-reactive protein, dysglycemia, and dyslipidemia (adjusted R(2)=35.8%; P<0.001). | 23887638 |
| Dyslipidemias, Hypertension, CTCAE, Osteoporosis, Fracture | Deregulated Nutrient Sensing | Male gender was found to be an independent risk factor for dyslipidaemia, severity of hypertension, lumbar osteoporosis and fractures. | 23889360 |
| Hypertensive disease, Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | This study explores the prevalence of herbal medicine use in a cohort of patients with chronic kidney disease (CKD), dyslipidemia and hypertension (HTN) in Jordan. | 23890462 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | A total of 700 CKD, dyslipidemia and hypertension patients were interviewed. | 23890462 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The majority of patients in this group had hypertension (n = 44, 83.0%), followed by dyslipidemia (n = 32, 60.4%). | 23890462 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | This study confirmed that there is an appreciable prevalence of herbal use among patients with CKD, dyslipidemia and hypertension in Jordan. | 23890462 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance and fasting plasma glucose in first degree relatives of patients with type 1 diabetes. | 23890682 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Our results suggest that taking into account the impact of age and BMI on insulin sensitivity, it would be expected that the relatives of patients with type 1 diabetes with "high-normal" glucose levels would become gradually unable to compensate for increasing insulin resistance. | 23890682 |
| Dyslipidemias, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with chronic kidney disease (CKD) often have mixed dyslipidemia and high cardiovascular disease risk. | 23891363 |
| TG gene, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The data suggest that, after 16 weeks of therapy, FA + R has an acceptable safety profile and improved TG and HDL-C efficacy versus R. FA + R combination therapy may thus further improve lipid parameters in patients with stage 3 CKD and mixed dyslipidemia. | 23891363 |
| Endometrial Serous Adenocarcinoma | Deregulated Nutrient Sensing | Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). | 23891627 |
| Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance possible risk factor for cognitive impairment in fibromialgic patients. | 23892884 |
| Impaired cognition, Federated States of Micronesia | Deregulated Nutrient Sensing | To evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment. | 23892884 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults. | 23894289 |
| Respiration Disorders | Deregulated Nutrient Sensing | Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. | 23894440 |
| Mitochondrial Diseases | Deregulated Nutrient Sensing | We further identify the integrated nutrient-sensing signaling network as a common cellular response that mediates, and may be amenable to targeted therapies for, tissue-specific sequelae of primary mitochondrial RC disease. | 23894440 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Insulin resistance is a well-documented risk factor for the development of endometrial cancer. | 23896633 |
| Alzheimers Disease", Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging. | 23897112 |
| Glucose Intolerance (disease), Data types - Address | Deregulated Nutrient Sensing | In this prospective cohort with multiple assessments of glucose intolerance and insulin resistance, measures of glucose and insulin homeostasis are not associated with AD pathology and likely play little role in AD pathogenesis. | 23897112 |
| Ataxia Telangiectasia | Deregulated Nutrient Sensing | Inhibition of DNA damage response by silencing of ataxia telangiectasia mutated (ATM) kinase resulted in upregulation of SIRT1 expression and decreased senescence. | 23897750 |
| ARCN1 gene | Deregulated Nutrient Sensing | Treatment of BOEC from COPD patients with the SIRT1 activator resveratrol or an ATM inhibitor (KU-55933) also rescued the senescent phenotype. | 23897750 |
| Hypertensive (finding), Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high collateralization (for all comparisons, P<0.05). | 23897789 |
| Periodontal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Many clinical studies suggest that periodontal diseases are risk factors for insulin resistance and diabetic mellitus development. | 23899607 |
| Sleep Disorders, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The increased incidence of impaired glucose tolerance (IGT), are serious public health issues, and several studies link sleeping disorders with increased risk of developing type 2 diabetes, impaired glucose tolerance and insulin resistance (IR). | 23902570 |
| Hypercholesterolemia, Hypertensive (finding), Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | From the 1960s to the 2000s, blood pressure control among hypertensive individuals improved significantly and the smoking rate decreased, but the prevalence of glucose intolerance, hypercholesterolemia, and obesity increased steeply. | 23902756 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Abnormalities in the autonomic nervous system in the presence of insulin resistance may be involved in the pathophysiology of obesity-associated hypertension. | 23903294 |
| nialamide, ETV3 wt Allele | Deregulated Nutrient Sensing | Normotensive men with MetS but with EIH have greater insulin resistance as well as lower HRV parasympathetic and sympathetic indices. | 23903294 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Dominantly inherited mutations cause less severe disease, which may progress to glucose intolerance and diabetes in later life (e.g., SUR1-E1506K). | 23903354 |
| Glucose Intolerance (disease), Failure (biologic function) | Deregulated Nutrient Sensing | We conclude that the gradual development of glucose intolerance in patients with the SUR1-E1506K mutation might, as in the mouse model, result from impaired insulin secretion due a failure of insulin content to increase with age. | 23903354 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Relevant comorbidities included diabetes (12 patients), hypertension (23 patients), and dyslipidemia (20 patients). | 23903461 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Using this database, we evaluated the lifestyles of patients with dyslipidemia by identifying risk factors for CHD development based on the JAS recommendations. | 23903499 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Those who were already being treated for dyslipidemia and had a history of CHD were excluded. | 23903499 |
| Papillary thyroid carcinoma | Deregulated Nutrient Sensing | AMP-activated protein kinase signaling is upregulated in papillary thyroid cancer. | 23904275 |
| Thyroid carcinoma | Deregulated Nutrient Sensing | However, AMPK signaling pathway in human thyroid carcinomas has not been investigated so far. | 23904275 |
| Papillary thyroid carcinoma | Deregulated Nutrient Sensing | To evaluate the expression and activity of AMPK in papillary thyroid carcinomas. | 23904275 |
| Papillary thyroid carcinoma, Carcinogenesis | Deregulated Nutrient Sensing | Our results show unequivocally that AMPK pathway is highly activated in papillary thyroid carcinomas; however, more studies are necessary to understand the pathophysiological significance of AMPK activation in thyroid carcinogenesis. | 23904275 |
| Malignant neoplasm of gastrointestinal tract | Deregulated Nutrient Sensing | Peroxisome proliferator-activated receptors (PPAR) are implicated in pathogenesis of insulin resistance and cancers of the digestive system. | 23907334 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Association of clinical and therapeutic factors with incident dyslipidemia in a cohort of human immunodeficiency virus-infected and non-infected adults: 1994-2011. | 23909647 |
| Dyslipidemias | Deregulated Nutrient Sensing | Marginal structural modeling suggested a significant association between incident dyslipidemia and exposure to both protease inhibitor- [adjusted rate ratio (aRR)=1.27; CI=1.08-1.49] and non-nucleoside reverse transcriptase inhibitor- (aRR=1.78; CI=1.19-2.66) based cART regimens. | 23909647 |
| Dyslipidemias, Diabetes Mellitus, Hepatitis C, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Pre-existing hypertension, obesity, and diabetes increased the risk of dyslipidemia, whereas hepatitis C virus, lower CD4(+) T cell count, and higher HIV viral load had a protective effect. | 23909647 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Incident dyslipidemia is lower in the early stages of HIV infection, but may significantly increase with cumulative exposure to cART. | 23909647 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | Thiamine deficiency and its correlation with dyslipidaemia in diabetics with microalbuminuria. | 23914634 |
| Microalbuminuria, Dyslipidemias | Deregulated Nutrient Sensing | To measure and correlate the levels of thiamine and dyslipidaemia in microalbuminuric diabetics. | 23914634 |
| Primary malignant neoplasm, Diabetes Mellitus | Deregulated Nutrient Sensing | These results may be environmentally important, in view of the central roles played in human physiology by ATPS and AMPK, particularly in their links to diabetes, cancer and longevity. | 23915261 |
| Increased insulin level, Hyperglycemia | Deregulated Nutrient Sensing | Hyperglycemia, hyperinsulinemia, insulin resistance, and the risk of BPH/LUTS severity and progression over time in community dwelling black men: the Flint Men's Health Study. | 23915515 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Higher IAAT was positively associated with increased dyslipidemia (p = 0.001), MS (p = 0.013) and NAFLD (p = 0.005). | 23919592 |
| Cessation of life, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia is one of several known risk factors for coronary heart disease, a leading cause of death in Lithuania. | 23919842 |
| square decimeter | Deregulated Nutrient Sensing | Chromium supplementation could be beneficial in patients with DM2 treated with insulin, most likely due to lowered insulin resistance leading to improved glucose tolerance. | 23921483 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Heart failure | Deregulated Nutrient Sensing | Mortality increased 3.7-fold with ST-elevation myocardial infarction (STEMI) and 3.0-fold with heart failure (HF) but decreased by 33% with dyslipidemia. | 23921507 |
| Dyslipidemias, Obesity, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | In- and peri-hospital mortality in ACS is significantly associated with age, gender, STEMI, HF, and dyslipidemia but not obesity measures. | 23921507 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that vitamin D deficiency is a potential risk factor for obesity and development of insulin resistance leading to diabetes type 2. | 23924693 |
| Weight decreased, Morbid obesity | Deregulated Nutrient Sensing | Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity. | 23928404 |
| Weight decreased | Deregulated Nutrient Sensing | Weight loss resulted in a significant induction of SIRT1, SIRT3, and SIRT6 expression in the subcutaneous adipose tissue. | 23928404 |
| Weight decreased | Deregulated Nutrient Sensing | In the liver, a significant increase after weight loss was observed, particularly for SIRT3 and SIRT6 mRNA expression; immunohistochemically, SIRT1 and SIRT3 expression was upregulated. | 23928404 |
| Tumor necrosis | Deregulated Nutrient Sensing | Endotoxin and tumor necrosis factor-alpha suppressed SIRT1, SIRT3, and SIRT6 expression in human monocytes. | 23928404 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Improvements were also noted for the diabetes markers fasting glucose (166 versus 131 mg/dl, P<0.05), fasting insulin (26.9 versus 10.4 mU/ml, P<0.05), and insulin resistance (9.6 versus 4.2, P=0.03). | 23929927 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Overall, transaminase activities, insulin resistance index, and hepatic fibrosis markers were significantly improved. | 23933938 |
| Fibrosis Assessment, Diabetes Mellitus | Deregulated Nutrient Sensing | At baseline, subjects in group R (n = 7) were more likely to have diabetes, insulin resistance, and severe fibrosis compared to those in group NR (n = 10). | 23933938 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Lower NAFLD activity score and larger decrease of ALT and insulin resistance after treatment were observed in group R compared with group NR. | 23933938 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, ETV3 wt Allele | Deregulated Nutrient Sensing | Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. | 23935829 |
| Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Hypertriglyceridemia, Obesity | Deregulated Nutrient Sensing | Our data suggest that in Chinese men, elevated SUA is significantly associated with NAFLD, independent of insulin resistance and other metabolic disorders, such as central obesity or hypertriglyceridemia. | 23935829 |
| Dyslipidemias, Overweight, Obesity, Prehypertension | Deregulated Nutrient Sensing | Factors as overweight, obesity, dyslipidemia appeared to be major risk factors for pre-hypertension. | 23937831 |
| Neoplasms | Deregulated Nutrient Sensing | The effects of topical rapamycin, an mTOR inhibitor, on mTORC1 and mTOR complex-2 (mTORC2) activities, as well as on tumor growth and migration, were determined. | 23938603 |
| Neoplasms, Vascular Tissue | Deregulated Nutrient Sensing | Rapamycin fully inhibited mTORC1 and partially inhibited mTORC2 activities, including the phosphorylation of Akt (serine 473) and PKCa, in vascular tumor cells. | 23938603 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Difference in office blood pressure, 24-hour blood pressure, arterial stiffness, endothelial function, cholesterol level, insulin resistance, and b-type natriuretic peptide level during 12 months. | 23939263 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Phase 1 to Phase 2: there were improvement on smoking cessation (P=0.019), dyslipidemia (P<0.001), hypertension and physical activity (P<0.001). | 23939321 |
| Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Sex, age, history of cardiovascular disease and/or diabetes mellitus, use of hydrochlorothiazide, and poor therapy adherence were statistically associated with a lack of dyslipidemia control. | 23939362 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | CONCLUSIONS Higher total energy intake was strongly associated with high levels of insulin resistance and may help to explain emerging type 2 diabetes risk in childhood. | 23939542 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The AMP-activated protein kinase (AMPK) serves as an energy sensor in eukaryotic cells and occupies a central role in linking metabolism and cancer development. | 23942093 |
| Liver carcinoma | Deregulated Nutrient Sensing | Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma. | 23942093 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | However, the phosphorylation status of AMPK and its therapeutic value in human hepatocellular carcinoma (HCC) remain unclear. | 23942093 |
| Hepatitis B, FAM126A gene | Deregulated Nutrient Sensing | The phosphorylation status of AMPK (Thr172) was determined by immunoblotting and immunostaining in specimens from 273 patients with HCC (including 253 patients with hepatitis B virus -related HCC). | 23942093 |
| FAM126A gene | Deregulated Nutrient Sensing | AMPK is dysfunctional in patients with HCC, and low p-AMPK staining is correlated with aggressive clinicopathologic features and poor prognosis. | 23942093 |
| FAM126A gene | Deregulated Nutrient Sensing | Activation of AMPK by metformin not only inhibited HCC cells growth in vitro and in vivo, but also augmented cisplatin-induced growth inhibition in HCC cells. | 23942093 |
| FAM126A gene | Deregulated Nutrient Sensing | These results present novel insight into a critical role of AMPK in HCC progression. | 23942093 |
| FAM126A gene | Deregulated Nutrient Sensing | Anticancer effects of therapeutic metformin/AMPK activation unravel metformin's potential in treatment of HCC. | 23942093 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | This inverse correlation between the insulin secretion rate and incident hypertension persisted after controlling for baseline insulin resistance, glycaemia and BP (p = 0.007). | 23942764 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | A low insulin secretion rate might be a new risk factor for incident hypertension, beyond insulin resistance. | 23942764 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Macrophage infiltration into adipose tissue during obesity and their phenotypic conversion from anti-inflammatory M2 to proinflammatory M1 subtype significantly contributes to develop a link between inflammation and insulin resistance; signaling molecule(s) for these events, however, remains poorly understood. | 23943623 |
| Dyslipidemias | Deregulated Nutrient Sensing | Management of dyslipidaemia is therefore suboptimal in this important high-risk group in UK standard practice. | 23944233 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Mechanisms linking liver functions with cardiometabolic risk may involve insulin resistance (IR) and non-alcoholic fatty liver disease. | 23945039 |
| Acquired Immunodeficiency Syndrome, Dyslipidemias, No metabolic abnormalities | Deregulated Nutrient Sensing | In the current two decades, dyslipidemia and increased blood glucose as metabolic abnormalities are the most common health threats with a high incidence among HIV/AIDS patients on antiretroviral (ARV) treatment. | 23947428 |
| Hypercholesterolemia, Pancreatitis, Dyslipidemias, Hypertriglyceridemia | Deregulated Nutrient Sensing | The blood samples highlighted a milky serum and allowed to diagnose an acute pancreatitis associated with a major dyslipidemia: hypertriglyceridemia 11,800 mg/dL and hypercholesterolemia 1195 mg/dL. | 23948029 |
| Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Cerebral Atherosclerosis, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients hospitalized with atherosclerotic cerebral ischemia with >= 1 major uncontrolled risk factor for stroke (hypertension, tobacco use, dyslipidemia, diabetes) were eligible to enroll in our study. | 23948623 |
| Dyslipidemias | Deregulated Nutrient Sensing | [Cardiovascular risk factors prevalence among patients with dyslipidemia in Colombia]. | 23949503 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The types of dyslipidemia by frequency were: mixed (46.6%), isolated hypercholesterolemia (29.4%) and hypertriglyceridaemia (20.3%). | 23949503 |
| Dyslipidemias | Deregulated Nutrient Sensing | Lipid-modulating treatments for mixed dyslipidemia increase HDL-associated phospholipase A2 activity with differential effects on HDL subfractions. | 23949918 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | We hypothesize that the vegetarian in Buddhism is associated with better metabolic profiles, lower risk for the MetS and insulin resistance (IR). | 23951247 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Small, dense LDL particles predict changes in intima media thickness and insulin resistance in men with type 2 diabetes and prediabetes--a prospective cohort study. | 23951331 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Elevated circulating levels of branched chain and aromatic amino acids (BCAA/AAAs) are associated with insulin resistance and incident type 2 diabetes (T2D). | 23953891 |
| Dyslipidemias | Deregulated Nutrient Sensing | ANA, as monotherapy or co-administered with ATV, produced significant reductions in LDL-C and increases in HDL-C. ANA was generally well tolerated in Japanese patients with dyslipidemia. | 23958252 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia | Deregulated Nutrient Sensing | Type 2 diabetes mellitus is characterized by prolonged hyperinsulinemia, insulin resistance, and progressive hyperglycemia. | 23962874 |
| Inflammation, hepcidin | Deregulated Nutrient Sensing | Also relations between visfatin and hepcidin, demands for recombinant human erythropoietin (rHuEpo), inflammation, and situations characterized by insulin resistance were evaluated. | 23964827 |
| Sleep Apnea Syndromes, Glucose Intolerance (disease), Heart failure, Hypertensive (finding), Chronic Kidney Diseases | Deregulated Nutrient Sensing | Smaller ancillary studies in hypertensive patients suggest a benefit from renal denervation in a variety of conditions such as chronic kidney disease, glucose intolerance, sleep apnoea and heart failure. | 23965354 |
| Endothelial dysfunction, Angina Pectoris, Variant | Deregulated Nutrient Sensing | Coronary spastic angina is associated with insulin resistance - possible involvement of endothelial dysfunction. | 23965946 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | There is increasing evidence that insulin resistance is associated with endothelial dysfunction. | 23965946 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among the patients, 50.3% were men, 4.0% had Medicaid health insurance, 17.8% had diabetes, 20.9% had dyslipidemia and 42.4% were adherent (MPR >= 80%). | 23966057 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Nonadherent patients (MPR<80%) were younger and more likely to have Medicaid health insurance; they had lower rates of diabetes and dyslipidemia compared with adherent patients. | 23966057 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Medically Unexplained Symptoms, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | However, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained. | 23967272 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Associations of circulating NAMPT levels with cardiovascular disease (CVD) and insulin resistance have been reported. | 23968400 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Insulin resistance (IR) is believed to be the underlying mechanism of metabolic syndrome and type 2 diabetes mellitus (DM). | 23977034 |
| Data types - Address | Deregulated Nutrient Sensing | Autopsy brain hippocampal tissues were obtained from controls and patients with AD and Western blots were performed using antibodies against mTOR signaling molecules and RagC, an upstream component of mTOR complex 1 (mTORC1) signaling. | 23979023 |
| Data types - Address | Deregulated Nutrient Sensing | Our data indicate that mTORC1, but not mTORC2, was activated in the AD brains and that the level of mTOR signaling activation was correlated with cognitive severity of AD patients. | 23979023 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease. | 23979023 |
| Spondylitis | Deregulated Nutrient Sensing | Correlation between insulin resistance and serum ghrelin in non-diabetic ankylosing spondylitis patients undergoing anti-TNF-a therapy. | 23981480 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In patients with low-LDL-C levels, diabetes with atherogenic dyslipidemia might be the key residual risk. | 23982317 |
| Increased insulin level | Deregulated Nutrient Sensing | Although cross-sectional associations do not prove causality, our findings do suggest that insulin resistance and in particular, hyperinsulinemia, may negatively affect bone strength relative to load. | 23983216 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obese children were likely to insulin resistance and dyslipidemia, which are risk factors of cardiovascular diseases. | 23984682 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Overweight and obese youths had reduced insulin sensitivity and high prevalence of dyslipidemia.When BMI-SDS elevated up to 1.22 and BMI was higher than 21.67 in boys, dyslipidemia may happen. | 23984682 |
| Burn Specimen Source Codes, Traumatic injury | Deregulated Nutrient Sensing | [Influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma]. | 23985210 |
| Burn Specimen Source Codes, Traumatic injury | Deregulated Nutrient Sensing | To discuss the influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma. | 23985210 |
| Burn Specimen Source Codes, Traumatic injury | Deregulated Nutrient Sensing | Intensive insulin therapy can alleviate insulin resistance of patients with severe burn or trauma. | 23985210 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To determine the prevalence and types of persistent dyslipidemia in patients treated with different statins to reduce cardiovascular disease (CVD) risk, as well as to determine the proportion of high risk patients who did not reach the lipid target values and assess cardiologists' further treatment advice for these patients. | 23986274 |
| Hirsutism | Deregulated Nutrient Sensing | Insulin resistance was significantly predicted by BMI, cholesterol, progesterone and presence of hirsutism. | 23988170 |
| Hirsutism, Prostate Cancer Outcomes Study, Periodicity | Deregulated Nutrient Sensing | The metformin therapy significantly improved insulin resistance, imbalance of endocrine hormones, hirsutism and menstrual cyclicity in women with PCOS. | 23988170 |
| Dyslipidemias | Deregulated Nutrient Sensing | ADT-induced changes in body composition are believed to contribute to a reduction in insulin sensitivity and dyslipidemia that contribute to increased cardiovascular risk profile. | 23989028 |
| hafnium, Ischemic, Dyslipidemias | Deregulated Nutrient Sensing | Most patients with HF have ischaemic aetiology, and therefore should apply the dietary recommendations for patients with dyslipidaemia and high cardiovascular risk. | 23990230 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was defined according to the NCEP ATP III guidelines. | 23991608 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The statistically significant related factors of dyslipidemia, including age, female gender, waist circumference, obesity, diabetes mellitus, smoker, current alcohol consumption, and postmenopausal women, were increased (p < 0.05). | 23991608 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia, based primarily on the presence of hypercholesterolemia and high LDL-C, was elevated in this population. | 23991608 |
| Dyslipidemias | Deregulated Nutrient Sensing | Development of a policy to prevent dyslipidemia is urgently needed. | 23991608 |
| Diabetes Mellitus, Obesity, Visceral, Cardiovascular Diseases | Deregulated Nutrient Sensing | Visceral obesity is associated with insulin resistance, diabetes, and cardiovascular diseases. | 23992351 |
| Ventricular hypertrophy | Deregulated Nutrient Sensing | According to our results, pericardial ghrelin content is negatively influenced by left ventricular hypertrophy and insulin resistance. | 23994275 |
| Hypertensive disease, Inflammation, Refractory anemias | Deregulated Nutrient Sensing | HTN in patients with RA is not associated with generalized systemic inflammation or insulin resistance, but is associated with increasing concentrations of homocysteine and leptin. | 23996293 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Also, the achievement rates of the target LDL-C goal suggested by the dyslipidemia treatment guideline of the Korean Society of Lipidology and Atherosclerosis were not different. | 23998970 |
| Primary malignant neoplasm, Dyslipidemias, Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Gynecologists have to care dyslipidemia in endometrial cancer survivors at cancer follow-up clinic. | 23999769 |
| Cerebrovascular Disorders, Dyslipidemias, Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Our report highlights the importance of the relationship between endometrial cancer and lipid metabolism, which may aid in preventing cerebrovascular or cardiovascular diseases due to dyslipidemia and improving the quality of life in endometrial cancer survivors. | 23999769 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In recent years, the number of patients with type 2 diabetes mellitus caused by insulin resistance has continued to increase in Japan. | 24002894 |
| Coronary Arteriosclerosis, Arteriosclerosis Obliterans, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is considered to be closely related to the risk of cardiovascular diseases and atherosclerotic diseases, represented by arteriosclerosis obliterans (ASO). | 24002894 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Therefore, improvement of insulin resistance is one of the important strategies in the treatment of type 2 diabetes mellitus. | 24002894 |
| FAM126A gene | Deregulated Nutrient Sensing | The human HCC cell lines HepG2 and PLC/PRF/5 were cultured and treated with metformin or 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), an activator of adenosine monophosphate (AMP)-activated protein kinase. | 24008375 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | 'Obese NAFLD' is associated with multiple changes in TAGs, which can be attributed to obesity/insulin resistance rather than increased liver fat content per se. | 24009255 |
| Low density lipoprotein increased, Dyslipidemias | Deregulated Nutrient Sensing | LY treatment produced significant improvements in dyslipidemia, including decreases in low-density lipoprotein cholesterol and triglycerides and increases in high-density lipoprotein cholesterol and a shift to a potentially less atherogenic apolipoprotein concentration profile. | 24011069 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Simultaneous prediction of hyperglycemia and dyslipidemia in school children in Santa Catarina State, Brazil based on waist circumference measurement. | 24012695 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Logistic regression analysis revealed that increased WC was associated with simultaneous hyperglycemia and dyslipidemia after controlling for differences in sex and age (P<0.01 for all). | 24012695 |
| Primary malignant neoplasm, Leukemia, Myelocytic, Acute | Deregulated Nutrient Sensing | Cancer cells require nutrients and energy to adapt to increased biosynthetic activity, and protein synthesis inhibition downstream of mammalian target of rapamycin complex 1 (mTORC1) has shown promise as a possible therapy for acute myeloid leukemia (AML). | 24014241 |
| Leukemia, Myelocytic, Acute | Deregulated Nutrient Sensing | We show in our current study that glutamine removal inhibits mTORC1 and induces apoptosis in AML cells. | 24014241 |
| Primary, Genus Erwinia | Deregulated Nutrient Sensing | We show that l-ases from both Escherichia coli and Erwinia chrysanthemi profoundly inhibit mTORC1 and protein synthesis and that this inhibition correlates with their glutaminase activity levels and produces a strong apoptotic response in primary AML cells. | 24014241 |
| Conventional (Clear Cell) Renal Cell Carcinoma | Deregulated Nutrient Sensing | Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients. | 24018803 |
| Breast Cancer Cell, Breast Carcinoma | Deregulated Nutrient Sensing | Recently, the important role of silent mating type information regulation 2 homolog 1 (SIRT1) and deleted in breast cancer 1 (DBC1) in human cancer has been extensively studied and their role has been closely related with the control of P53 and androgen receptor (AR) functions. | 24018803 |
| Refractory anemias, Rheumatoid Arthritis, Chronic inflammatory disorder | Deregulated Nutrient Sensing | Rheumatoid arthritis (RA), a chronic inflammatory disease, is associated with insulin resistance. | 24020899 |
| Refractory anemias, Inflammation | Deregulated Nutrient Sensing | Therefore, we examined the hypothesis that pioglitazone, a thiazolidinedione peroxisome proliferator-activated receptor g agonist, would decrease inflammation and disease activity and improve insulin resistance in patients with RA. | 24020899 |
| Refractory anemias, Disease | Deregulated Nutrient Sensing | Addition of pioglitazone to RA therapy improves insulin resistance and modestly reduces RA disease activity measured by DAS28-CRP and two of its components, including patient-reported global health and CRP, but not DAS28-ESR or ESR. | 24020899 |
| Dental Plaque | Deregulated Nutrient Sensing | Insulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis. | 24022065 |
| Atherosclerosis | Deregulated Nutrient Sensing | Previous studies have reported that insulin resistance plays an important role in the progression of atherosclerosis. | 24022065 |
| Dental Plaque | Deregulated Nutrient Sensing | However, the relationship between insulin resistance and coronary plaque instability is not well established. | 24022065 |
| Dental Plaque | Deregulated Nutrient Sensing | This study suggests that insulin resistance might be associated with coronary plaque vulnerability. | 24022065 |
| Dyslipidemias | Deregulated Nutrient Sensing | From the multivariate stepwise analysis, independent risk factors for annual mortality were male gender (OR = 3.432; p = 0.043), left ventricular systolic dimension (OR = 1.871; p = 0.004) and dyslipidemia (OR = 0.252; p = 0.043). | 24022323 |
| Dyslipidemias, Cerebral Hemorrhage, Cerebrovascular accident | Deregulated Nutrient Sensing | Increasing age, higher National Institutes of Health Stroke Scale score, and history of dyslipidemia were associated with symptomatic intracerebral hemorrhage. | 24024962 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Acanthosis nigricans, an indicator of insulin resistance, was identified in nearly 27% of the student records. | 24027953 |
| Chronic Kidney Diseases, Ventricular hypertrophy | Deregulated Nutrient Sensing | Vitamin D deficiency, insulin resistance, and ventricular hypertrophy in the early stages of chronic kidney disease. | 24028070 |
| Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | Thiazolidinediones (TZDs) - rosiglitazone and pioglitazone - a class of insulin sensitizer for treating type 2 diabetes, have been reported to exhibit neuroprotective effects in preclinical studies and have good effects in the control of blood sugar for diabetic patients with insulin resistance. | 24029780 |
| ACSM3 gene, Non-insulin Hypoglycemic, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, NEUROD1 wt Allele | Deregulated Nutrient Sensing | The MHR was evaluated according to age and gender, adjusted for Hypertension (SAH), dyslipidemia and non-insulin dependent diabetes mellitus (NIDDM). | 24029962 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia, hypertension and DM did not influence the findings. | 24029962 |
| ACSM3 gene, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of SAH, dyslipidemia and diabetes mellitus did not influence the results. | 24029962 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1. | 24035280 |
| Neoplasms | Deregulated Nutrient Sensing | SIRT1 and p300/CBP, which are considered to be essential histone deacetylases and acetyltransferases, are also considered to be relative to tumorigenesis because they modulate the expression of several tumor suppressor genes. | 24035280 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Therefore, this study investigated the expression of SIRT1 and p300/CBP in gastroesophageal junction (GEJ) cancer and their correlation with E-cadherin and MLH1 in order to explore the clinicopathological significance of SIRT1 and p300/CBP expression and their possible effects involving E-cadherin and MLH1 expression. | 24035280 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | The results showed that the over-expression of SIRT1 was associated with a higher number of metastasis lymph nodes, more advanced staging, and shorter mean survival time. | 24035280 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | SIRT1 and p300/CBP were negatively and positively correlated with the expression of E-cadherin and MLH1, respectively, in the cancer cases. | 24035280 |
| Neoplasms | Deregulated Nutrient Sensing | These results indicated a possible effect of SIRT1 and p300/CBP involved in regulating the expression of E-cadherin and MLH1, thus participating in the tumor progression of GEJ cancer. | 24035280 |
| GDC AJCC Clinical Stage Terminology, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Under an additive model, the "AA" genotype was associated with an increased risk of developing ACS, adjusted for gender, hypertension, dyslipidemia, alcohol consumption, smoking, and diabetes (OR=1.56, p=0.045). | 24035903 |
| Retinal Degeneration, Inflammation, methyldopa | Deregulated Nutrient Sensing | Our findings suggest a protective role for SIRT1 signaling in Ab-dependent retinal degeneration and inflammation in AMD. | 24036938 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Metabolically healthy subjects were free from hypertension, dyslipidaemia, impaired glucose regulation and insulin resistance. | 24039900 |
| Obesity | Deregulated Nutrient Sensing | HMW adiponectin was positively correlated with HDL cholesterol and negatively correlated with triglycerides, obesity, insulin resistance and blood glucose. | 24039900 |
| Overweight | Deregulated Nutrient Sensing | A-FABP and its association with atherogenic risk profile and insulin resistance in young overweight and obese women. | 24044564 |
| Weight decreased | Deregulated Nutrient Sensing | There was a statistically significant correlation between change in waist circumference and change in insulin resistance (P<0.02), and between HbA1c and weight loss (P<0.002). | 24044780 |
| Increased insulin level | Deregulated Nutrient Sensing | Subjects with FHT2D showed a higher prevalence of hyperinsulinemia and insulin resistance (IR) than those without FHT2D (14.4 vs. 5.7%, p = 0.029, and 14.2 vs. 7.0% p = 0.050, respectively). | 24051035 |
| Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Lipocalin-2 has been recently identified as an adipokine present in the circulation, it is related to insulin resistance, obesity, atherosclerotic diseases and type 2 diabetes. | 24052155 |
| Albuminuria, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Albuminuria was significantly associated with increased Framingham Risk Score (P=.002), insulin resistance by HOMA-IR (P=.02), diastolic blood pressure (P=.01), and carotid intima-media thickness (P =.04). | 24052917 |
| Glucose Intolerance (disease), Blood Glucose | Deregulated Nutrient Sensing | In fact, in DexHmb rats, there was increased fasting glycemia and exacerbated glucose intolerance with the main effect attributed to DEX treatment (p < 0.05). | 24053521 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | In fact, the data suggest that HMB may exacerbate GC-induced glucose intolerance. | 24053521 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro. | 24054871 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | To examine the ability of dual mTORc1/c2 inhibitors in conjunction with lapatinib to function in a synergistic manner to inhibit cell proliferation and anchorage-independent growth in bladder cancer cell lines. | 24054871 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | Three bladder cancer cell lines, T24, HT1376, and UM-UC-3, were analyzed for cell proliferation after treatment with mTORc1/c2 inhibitors OSI-027 or PP242. | 24054871 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The Enhanced Fitness trial enrolled overweight/obese (body mass index >25) sedentary patients with glucose intolerance but without overt diabetes. | 24055327 |
| Dyslipidemias, Kidney Failure, Cerebrovascular accident | Deregulated Nutrient Sensing | Atherogenic dyslipidemia and renal insufficiency are suggested to be early predic.tors for stroke and should be closely monitored in Saudi HF patients. | 24060720 |
| Prediabetes syndrome, Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Twenty to thirty percent of obese youth have "prediabetes," a precursor to diabetes marked by insulin resistance, b-cell dysfunction, and impaired glucose tolerance. | 24062325 |
| diabetic | Deregulated Nutrient Sensing | Blood viscosity (BV) is higher in diabetic patients and might represent a risk factor for the development of insulin resistance and type 2 diabetes. | 24062332 |
| Weight decreased, Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | We found that despite significant weight loss, improvements in cardiovascular risk factors (dyslipidemia and obstructive sleep apnea), and quality of life in our patients, bariatric surgery does not necessarily lead to improved glycemic control of T1DM. | 24062368 |
| Fatty degeneration | Deregulated Nutrient Sensing | MedDietScore was negatively correlated to patients' serum alanine aminotransferase (p = 0.03) and insulin levels (p = 0.001), insulin resistance index (p = 0.005) and severity of steatosis (p = 0.006) and positively to serum adiponectin levels (p = 0.04). | 24064253 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Higher adherence to the Mediterranean diet is not associated with lower likelihood of having NAFLD, but it is associated with less degree of insulin resistance and less severe liver disease among patients with NAFLD. | 24064253 |
| Thrombosis, Ventricular Dysfunction, Left, Atherosclerosis, Dyslipidemias, Endothelial dysfunction, Cardiac Arrhythmia | Deregulated Nutrient Sensing | Low T has been linked to increased blood pressure, dyslipidemia, atherosclerosis, arrhythmia, thrombosis, endothelial dysfunction, as well as to impaired left ventricular function. | 24064693 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Sex differences in insulin resistance and cardiovascular disease risk. | 24064694 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | MetS had no impact on CIMT in morbid obese individuals possibly due to established insulin resistance earlier than MetS. | 24065221 |
| Obesity | Deregulated Nutrient Sensing | In obesity, elevated insulin resistance is observed, which may be associated with disturbances in mineral status in the body. | 24065235 |
| Malignant neoplasm of esophagus | Deregulated Nutrient Sensing | Fast-track surgery improves postoperative clinical recovery and reduces postoperative insulin resistance after esophagectomy for esophageal cancer. | 24068549 |
| Malignant neoplasm of esophagus | Deregulated Nutrient Sensing | This study aims to investigate the influence of fast-track surgery (FTS) on insulin resistance indicators in a prospective randomized, controlled clinical trial in esophageal cancer patients. | 24068549 |
| Malignant neoplasm of esophagus | Deregulated Nutrient Sensing | FTS promotes early recovery of gastrointestinal function and reduces stress reaction and postoperative insulin resistance after esophagectomy for esophageal cancer. | 24068549 |
| Dyslipidemias | Deregulated Nutrient Sensing | Marked insulin resistance and the associated dyslipidaemia are not clinical features of HNF1A-MODY carriers. | 24069322 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Higher levels of monocyte CD36 and plasma CD36(sCD36) are seen to cluster with insulin resistance and diabetes. | 24069322 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | Elevated expression of eukaryotic protein synthesis initiation factor 4E (eIF4E) in histologically cancer-free margins of resected head and neck squamous cell carcinomas (HNSCCs) is mediated by mammalian target of rapamycin complex 1 (mTORC1) and has been associated with increased risk of disease recurrence. | 24074921 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Preclinically, inhibition of mTORC1 with everolimus sensitizes cancer cells to cisplatin and radiation. | 24074921 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | The regimen merits further evaluation, especially among patients who are status post resection of HNSCCs that harbor mTORC1-mediated activation of eIF4E in histologically negative surgical margins. | 24074921 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polymorphisms in the CNR1 gene (encoding CB1 receptor) were previously found to be associated with dyslipidemia and cardiovascular diseases. | 24075694 |
| diabetic | Deregulated Nutrient Sensing | In diabetics, PWV did not correlate with MAP, suggesting that other structural alterations, resulting from insulin resistance, may account for diabetic arterial stiffening to a greater extent than, and independently of, blood pressure. | 24075763 |
| Asthma, Dyslipidemias | Deregulated Nutrient Sensing | The findings of this pilot study suggest a role of LDL in asthma, and advocate for larger studies to confirm the association between asthma and dyslipidemia. | 24075885 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Caucasians and African immigrants in France had lower HbA1c values than Africans in Cameroon (P<0.001); they were also more aggressively treated for hypertension and dyslipidaemia and, therefore, had significantly lower blood pressure levels and better lipid profiles. | 24076360 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum IL-18 and hsCRP correlate with insulin resistance without effect of calcitriol treatment on type 2 diabetes. | 24076594 |
| diabetic | Deregulated Nutrient Sensing | To investigate the association between insulin resistance and inflammatory markers, and assessing the effects of oral Calcitriol on inflammatory cytokines in type 2 diabetic patients. | 24076594 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | Inflammation was associated with insulin resistance in diabetic patients. | 24076594 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The influence of fenofibrate on lipid profile, endothelial dysfunction, and inflammatory markers in type 2 diabetes mellitus patients with typical and mixed dyslipidemia. | 24079286 |
| TG gene, Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Patients present with typical dyslipidemia (predominantly high levels of triglycerides [TG] and low levels of high-density lipoprotein cholesterol [HDL-C]) or mixed hypercholesterolemia (high levels of low-density lipoprotein cholesterol [LDL-C] and TG with low HDL-C). | 24079286 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We administered micronized fenofibrate (Laboratories Fourneir S.A Dijon, France) daily for 8 weeks to 40 dyslipidemic, type 2 diabetes patients with equal numbers in each arm of the typical or mixed dyslipidemia groups. | 24079286 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Lipid classes and species associated with type 2 diabetes provide support for a number of existing paradigms of dyslipidemia and suggest new avenues of investigation. | 24086336 |
| Inflammation, Dyslipidemias, Dysglycemia | Deregulated Nutrient Sensing | Altered cardiac function, dysglycemia and dyslipidemia do not seem to be significantly associated with AHR in severely obese subjects in contrast to systemic inflammation. | 24088331 |
| Pancreatic Ductal Adenocarcinoma | Deregulated Nutrient Sensing | High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. | 24088390 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. | 24088390 |
| ANOPHTHALMIA AND PULMONARY HYPOPLASIA, Pancreatic Ductal Adenocarcinoma | Deregulated Nutrient Sensing | Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expression profile and prognostic significance of Sirt1 in vivo as well as cellular effects of Sirt1 inhibition in vitro. | 24088390 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Accordingly, overexpression of Sirt1 led to increased cell viability, while small molecule inhibition led to a growth arrest in pancreatic cancer cells and impaired cell survival. | 24088390 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Sirt1 is an independent prognosticator in PDACs and plays an important role in pancreatic cancer cell growth, which can be levered out by small molecule inhibition. | 24088390 |
| Alzheimers Disease", Dyslipidemias, Data types - Address | Deregulated Nutrient Sensing | Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood. | 24088526 |
| Sarcopenia, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, sarcopenia showed an association with insulin resistance, diabetes, and MS, in the non-obese population. | 24088600 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Oral health conditions have a significant relationship with diabetes mellitus (DM) as well as dyslipidemia. | 24095848 |
| Degenerative polyarthritis, Nonerosive Arthritis, Dyslipidemias, Metabolic Syndrome X | Deregulated Nutrient Sensing | Individuals with erosive osteoarthritis (n=80) had an increased risk of metabolic syndrome (2.7; 1.0 to 7.1), notably dyslipidaemia (4.7; 2.1 to 10.6) compared with non-erosive osteoarthritis classed K&L>=3 (n=193). | 24095935 |
| Degenerative polyarthritis, Dyslipidemias | Deregulated Nutrient Sensing | Metabolic exposures, dyslipidaemia in particular, may be implicated in erosive osteoarthritis. | 24095935 |
| Increased insulin level, Portal Hypertension, Cirrhotic | Deregulated Nutrient Sensing | Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension. | 24096983 |
| Increased insulin level, Saint Lucia, Liver Dysfunction, Liver Cirrhosis | Deregulated Nutrient Sensing | Liver cirrhosis (LC) is often complicated by hyperinsulinemia due to insulin resistance (IR), which is considered to be closely related to shunt formation and impaired liver function. | 24096983 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Coronary risk factors (ie, hypertension, dyslipidemia, diabetes mellitus, family history, and smoking) were obtained from the patient medical records. | 24097215 |
| Coronary Stenosis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | According to multivariable analysis, the factors affecting coronary stenosis were age, gender, dyslipidemia, diabetes mellitus, and the ratio of visceral to subcutaneous fat. | 24097215 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | This gene could then be added to a set of genetic markers to identify individuals with an increased risk for developing T2DM and complications associated with dyslipidemia in diabetic patients. | 24098457 |
| Glucose Intolerance (disease), Pancreatitis, Obesity | Deregulated Nutrient Sensing | Obesity and type 2 diabetes--diseases linked to glucose intolerance and insulin resistance--have been positively associated with the risk of acute pancreatitis. | 24100113 |
| Obesity, Osage language | Deregulated Nutrient Sensing | Plasma glucose, HbA1c, and insulin resistance were compared according to OSA and obesity status. | 24101695 |
| Coronary Artery Disease, Angina Pectoris | Deregulated Nutrient Sensing | Differential associations of angiographic extent and severity of coronary artery disease with asymmetric dimethylarginine but not insulin resistance in non-diabetic men with stable angina: a cross-sectional study. | 24103320 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-kB/Cyclin D1 signaling. | 24107295 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | However, the function of SIRT1 in cancer remains controversial. | 24107295 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Here, the expression and role of SIRT1 in gastric cancer is delineated. | 24107295 |
| Stomach Neoplasms | Deregulated Nutrient Sensing | SIRT1 was present in all normal gastric mucosa specimens; however, it was only present in a portion of the matched gastric cancer tumor specimens. | 24107295 |
| Neoplasms | Deregulated Nutrient Sensing | In SIRT1-positive tumors, both mRNA and protein levels were downregulated as compared with the corresponding nonneoplastic tissue. | 24107295 |
| Negative Regulation of Cell Cycle, Stomach Carcinoma | Deregulated Nutrient Sensing | Ectopic expression of SIRT1 inhibited cell proliferation, diminished clonogenic potential, and induced a G1-phase cell-cycle arrest, the effects of which were not apparent when a catalytic-domain mutant form of SIRT1 was introduced, suggesting that SIRT1 functions in gastric cancer are dependent on its deacetylase activity. | 24107295 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | This work characterizes SIRT1 status and demonstrates its inhibitory function in gastric cancer development, which involves NF-kB/Cyclin D1 signaling, offering a therapeutic role for SIRT1 activators. | 24107295 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | The inhibitory functions of SIRT1, which involve NF-kB/Cyclin D1 signaling, suggest the utility of SIRT1 activators in the prevention and therapy of gastric cancer. | 24107295 |
| Primary malignant neoplasm, Liver diseases, Dyslipidemias, Coronary heart disease, Diabetes Mellitus, Heart failure, Obesity, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | Variables used in both analyses were hypertension, obesity, diabetes, dyslipidaemia, heart failure, coronary heart disease, renal failure, liver disorders and cancer. | 24107981 |
| Chronic infectious disease, Hepatitis C | Deregulated Nutrient Sensing | Chronic infection with the hepatitis C virus (HCV) is associated with a higher prevalence of insulin resistance compared to the general population. | 24114816 |
| Steatohepatitis, Fibrosis Assessment | Deregulated Nutrient Sensing | The association of insulin resistance, hepatic steatosis and liver fibrosis was also investigated. | 24114816 |
| Fatty degeneration | Deregulated Nutrient Sensing | Insulin resistance was found in 27 (61%) patients and significant steatosis in 37 (84%) patients. | 24114816 |
| Fatty degeneration | Deregulated Nutrient Sensing | Comparison between patients with HCV genotype 1 and 3 showed insulin resistance in 15 (65%) vs. 12 (57%), respectively (P = 0.81) and steatosis in 19 (83%) vs. 18 (86%), respectively (P = 0.93). | 24114816 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | Comparison between patients with and without insulin resistance showed, respectively, a higher prevalence of significant fibrosis (56% vs. 6%; P = 0.0001), and a higher mean degree of steatosis (1.3 +- 0.72 vs. 0.76 +- 0.56; P = 0.01). | 24114816 |
| Hepatitis C | Deregulated Nutrient Sensing | Prevalence of insulin resistance was not different between HCV infected patients with genotype 1 vs. 3. | 24114816 |
| Fibrosis Assessment, Fatty degeneration | Deregulated Nutrient Sensing | Nevertheless, independent of HCV genotype, there was a statistically significant relationship between insulin resistance and a higher amount of liver fibrosis and steatosis. | 24114816 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Central (truncal) adiposity is associated strongly with insulin resistance and diabetes. | 24116041 |
| Low Density Array | Deregulated Nutrient Sensing | After adjustment for conventional cardiovascular risk factors, such as age, waist circumference, smoking history, low-density and high-density lipoprotein cholesterol, triglycerides, systolic blood pressure and insulin resistance, the ORs (95%CI) of the third tertile adiponectin group were 0.42 (0.25-0.72) in men and 0.47 (0.29-0.75) in women. | 24116054 |
| Dyslipidemias, Xerostomia | Deregulated Nutrient Sensing | To evaluate the correlation between dyslipidemia in patients with oral dryness and the development of non-specific histopathological findings in their labial salivary gland biopsies. | 24118379 |
| Dyslipidemias, Xerostomia | Deregulated Nutrient Sensing | Thirty seven patients suffering from oral dryness (18 patients with dyslipidemia and 19 age-matched patients with normal lipid blood levels) underwent labial salivary gland biopsy. | 24118379 |
| Dyslipidemias, Chronic disease | Deregulated Nutrient Sensing | Multidisciplinary approaches, such as the chronic care model, have been applied to other chronic diseases and likely would be applicable to the management of dyslipidaemia. | 24118549 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our study identifies different components of a multidisciplinary approach to management of dyslipidaemia that are efficacious and these results may help guide future investment in this area. | 24118549 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | MRI-diagnosed nonalcoholic fatty liver disease is correlated to insulin resistance in adolescents. | 24119357 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | To evaluate the presence of nonalcoholic fatty liver disease (NAFLD) in eutrophic and obese adolescents with magnetic resonance imaging (MRI) and its relationship to insulin resistance and other potential biomarkers. | 24119357 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Our results suggest that sedentary postmenopausal women with an appendicular skeletal muscle mass index above 7.025 kg/m(2) may be at greater risk of insulin resistance. | 24120357 |
| Communicable Diseases, Hepatitis C, Diabetes Mellitus | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) infection is causally associated with insulin resistance and diabetes mellitus. | 24122848 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance is associated with Fibroblast Growth Factor-23 in stage 3-5 chronic kidney disease patients. | 24125760 |
| Calcification of coronary artery, SLC25A20 gene, Chronic Kidney Diseases | Deregulated Nutrient Sensing | To determine the associations between insulin resistance, fibroblast growth factor 23 (FGF-23), and coronary artery calcification (CAC) in chronic kidney disease (CKD) patients. | 24125760 |
| FGF23 protein, human, Atherosclerosis, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | FGF-23 is associated with atherosclerosis and cardiovascular disease, but its association with insulin resistance in CKD has not been explored. | 24125760 |
| SLC25A20 gene, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistant CKD patients demonstrated higher FGF-23 levels, and increased CAC, while PO4 levels remained normal, suggesting a potential link between insulin resistance and PO4 homeostasis in CKD. | 24125760 |
| Prostate carcinoma, Neoplasms | Deregulated Nutrient Sensing | SIRT1, which may act either as tumor suppressor or oncogene, reduces H2A.Z levels in cardiomyocytes, via proteasome-mediated degradation, and this mechanism might be impaired in prostate cancer cells due to sirtuin 1 downregulation. | 24127549 |
| Carcinogenesis | Deregulated Nutrient Sensing | Thus, we aimed to characterize the mechanisms underlying H2A.Z and SIRT1 deregulation in prostate carcinogenesis and how they interact. | 24127549 |
| Primary malignant neoplasm, Prostatic Intraepithelial Neoplasias | Deregulated Nutrient Sensing | We found that H2AFZ and SIRT1 were up- and downregulated, respectively, at transcript level in primary prostate cancer and high-grade prostatic intraepithelial neoplasia compared to normal prostatic tissues. | 24127549 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Induced SIRT1 overexpression in prostate cancer cell lines resulted in almost complete absence of H2A.Z. | 24127549 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. | 24127549 |
| Prostate carcinoma | Deregulated Nutrient Sensing | We concluded that sirtuin 1 and H2A.Z deregulation in prostate cancer are reciprocally related. | 24127549 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Epigenetic modifying drugs in conjunction with enzymatic modulators are able to restore the normal functions of sirtuin 1 and might constitute relevant tools for targeted therapy of prostate cancer patients. | 24127549 |
| Obesity | Deregulated Nutrient Sensing | Adipose dipeptidyl peptidase-4 and obesity: correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro. | 24130353 |
| Obesity, Visceral, Metabolic Syndrome X | Deregulated Nutrient Sensing | Our data suggest that DPP4 may be a marker for visceral obesity, insulin resistance, and the metabolic syndrome. | 24130353 |
| Non-alcoholic Fatty Liver Disease, Obesity, Visceral, Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and nonalcoholic fatty liver disease (NAFLD) independent of visceral obesity in Koreans and to examine whether the associations differ according to the presence of diabetes or insulin resistance. | 24130687 |
| Non-alcoholic Fatty Liver Disease, Obesity, Visceral, Diabetes Mellitus | Deregulated Nutrient Sensing | Low vitamin D status is closely associated with NAFLD, independent of visceral obesity in subjects with diabetes or insulin resistance. | 24130687 |
| Communicable Diseases, Inflammation | Deregulated Nutrient Sensing | Although markers of inflammation and insulin resistance are also related to the onset of surgical infection, leptin correlates more closely with the risk of infection than does any other factor. | 24132530 |
| Hypertensive (finding), Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hypertensive patients have higher prevalence of insulin resistance and are at increased risk of developing type 2 diabetes mellitus (DM). | 24132701 |
| Erectile dysfunction | Deregulated Nutrient Sensing | Activin A released from epicardial adipose tissue has been linked to contractile dysfunction and insulin resistance in cardiomyocytes. | 24134550 |
| Dyslipidemias | Deregulated Nutrient Sensing | Depressive symptomatology was significantly associated with high total cholesterol, high triglycerides, low high-density lipoprotein cholesterol (HDL-C), high low-density lipoprotein cholesterol (LDL-C), and dyslipidemia (p < 0.05). | 24136399 |
| Triglycerides, Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Bipolar Disorder | Deregulated Nutrient Sensing | Elevated depressive symptoms are associated with lipid profile characterized by high cholesterol, high triglycerides, low HDL-C, high LDL-C, and dyslipidemia; the associations are partially mediated by ischemic heart disease and stroke. | 24136399 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Genetic variations in inflammatory response and insulin resistance may affect the risk of obesity- and diabetes-related pancreatic cancer. | 24136929 |
| Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia due to diabetes is characterized by hypertriglyceridemia and reduced levels of high-density lipoprotein cholesterol (HDL-C) and elevated or normal levels of low-density lipoprotein cholesterol (LDL-C) in type 2 diabetes mellitus (T2DM). | 24138536 |
| Cardiovascular Diseases, diabetic, Cerebrovascular accident | Deregulated Nutrient Sensing | Although elevated serum C-peptide level as an indicator of insulin resistance increases the obesity-associated risk of cardiovascular disease among diabetic patients, evidence indicating that serum C-peptide level is associated with stroke in nondiabetic subjects is limited. | 24139410 |
| Autoimmune Diseases, Obesity | Deregulated Nutrient Sensing | Accordingly, TNF a has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance. | 24139907 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | After adjustment by a stepwise logistic regression method, hypertension, dyslipidemia, and CA+AA genotype were found to be significantly associated with T2D. | 24139907 |
| NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology | Deregulated Nutrient Sensing | Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome. | 24140093 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Variants of estrogen receptor a (ERa) have been associated with obesity, dyslipidemia, diabetes and blood pressure. | 24140101 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia, coronary artery calcium, and incident atherosclerotic cardiovascular disease: implications for statin therapy from the multi-ethnic study of atherosclerosis. | 24141324 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Atherosclerosis | Deregulated Nutrient Sensing | Worldwide clinical practice guidelines for dyslipidemia emphasize allocating statin therapy to those at the highest absolute atherosclerotic cardiovascular disease (CVD) risk. | 24141324 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | We examined 5534 Multi-Ethnic Study of Atherosclerosis (MESA) participants who were not on baseline medications for dyslipidemia. | 24141324 |
| SLC25A20 gene, Dyslipidemias | Deregulated Nutrient Sensing | Across the spectrum of dyslipidemia, event rates similar to secondary prevention populations were observed for patients with CAC >= 100. | 24141324 |
| Albuminuria | Deregulated Nutrient Sensing | Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. | 24141423 |
| Diabetic Neuropathies | Deregulated Nutrient Sensing | Here we investigated the protective role of Sirt1 in diabetic renal damage. | 24141423 |
| Albuminuria, diabetic | Deregulated Nutrient Sensing | We found that Sirt1 in proximal tubules (PTs) was downregulated before albuminuria occurred in streptozotocin-induced or obese (db/db) diabetic mice. | 24141423 |
| Albuminuria, Diabetes Mellitus | Deregulated Nutrient Sensing | PT-specific SIRT1 transgenic and Sirt1 knockout mice showed prevention and aggravation of the glomerular changes that occur in diabetes, respectively, and nondiabetic knockout mice exhibited albuminuria, suggesting that Sirt1 in PTs affects glomerular function. | 24141423 |
| Albuminuria | Deregulated Nutrient Sensing | Downregulation of Sirt1 and upregulation of the tight junction protein Claudin-1 by SIRT1-mediated epigenetic regulation in podocytes contributed to albuminuria. | 24141423 |
| Proteinuria, Diabetes Mellitus | Deregulated Nutrient Sensing | In human subjects with diabetes, the levels of SIRT1 and Claudin-1 were correlated with proteinuria levels. | 24141423 |
| Albuminuria, Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest that Sirt1 in PTs protects against albuminuria in diabetes by maintaining NMN concentrations around glomeruli, thus influencing podocyte function. | 24141423 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study. | 24141640 |
| Increase, Obesity | Deregulated Nutrient Sensing | We show that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin resistance, and protects against age-related obesity. | 24142699 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The risk factors include insulin resistance, obesity, dyslipidemia, and hypertension and it is known to increase the risk for CVD and type II diabetes. | 24144655 |
| Units Of Measure - Siemens | Deregulated Nutrient Sensing | Physical activity was associated with MHO defined by insulin resistance (OR 1.87, 95% CI 1.19-2.92, p = 0.006). | 24146838 |
| Dyslipidemias, Depression, CTCAE, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Differences were observed with respect to concomitant disease/other risk factors (depression, dyslipidemia, cardiovascular disease, hypertension). | 24150103 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | Relationship between thyroid nodules and non-functioning adrenal incidentalomas and their association with insulin resistance. | 24152247 |
| Adrenal incidentaloma | Deregulated Nutrient Sensing | The relationship between insulin resistance and thyroid nodules in patients with non-functional adrenal incidentalomas (AI) is not clearly understood. | 24152247 |
| Inflammation | Deregulated Nutrient Sensing | The significant mediating role of low-grade inflammation in the association between the ADII and HOMA-IR suggests that inflammation might be one of the pathways through which diet affects insulin resistance. | 24153342 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effect of atorvastatin on baroreflex sensitivity in subjects with type 2 diabetes and dyslipidaemia. | 24154932 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A total of 79 patients with type 2 diabetes with dyslipidaemia were recruited. | 24154932 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A low dose of atorvastatin increased BRS in non-obese subjects with type 2 diabetes and dyslipidaemia after 1-year treatment. | 24154932 |
| Hypertriglyceridemia, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. | 24156295 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Common and low-frequency variants in AGPAT6 do not significantly associate with type 2 diabetes susceptibility, or influence related phenotypic traits such as obesity, dyslipidemia or indices of insulin sensitivity or insulin secretion in the population studied. | 24156295 |
| Dyslipidemias, Injury of cardiac valve, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | After adjusting for conventional risk factors (age, gender, smoking, diabetes mellitus, dyslipidemia, hypertension), free triiodothyronine (FT3) was significantly and negatively correlated with log-CKMB (r = -0.244, P < 0.001) and log-cTnI (r = -0.290, P < 0.001), indicating that the lower thyroid hormone level correlates with the severer cardiac injury in STEMI patients. | 24157158 |
| square decimeter, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Mexicor promoted combined hypolipidemic effect, reduced the degree of insulin resistance, improved hepatic metabolism, and lowered cardiovascular risks in patients with CHD and DM2. | 24159791 |
| Dyslipidemias | Deregulated Nutrient Sensing | Mexicor was shown to act as a hepatoprotector reducing the frequency of cytolithic syndrome when used together with statins in combined therapy of atherogenic dyslipidemia. | 24159791 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Associations of organochlorine pesticides and polychlorinated biphenyls in visceral vs. subcutaneous adipose tissue with type 2 diabetes and insulin resistance. | 24161582 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | As OC pesticides and PCBs mainly accumulate in adipose tissue and there are physiological and clinical differences between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), we explored if there were associations of OC pesticides and PCBs in VAT or SAT with type 2 diabetes and insulin resistance. | 24161582 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Some OC pesticides or PCBs, such as dichlorodiphenyltrichloroethanes (DDTs), chlordanes, and PCBs with 5 or less chlorides showed significant associations with diabetes or insulin resistance. | 24161582 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Non-calcified plaques were positively associated with male gender, age, dyslipidaemia and diabetes mellitus. | 24162317 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | Plasma gamma-glutamyltransferase is strongly determined by acylation stimulating protein levels independent of insulin resistance in patients with acute coronary syndrome. | 24167361 |
| Fatty degeneration | Deregulated Nutrient Sensing | Mechanisms involved in enhanced hepatic lipogenesis causing steatosis are not yet identified and are usually linked to insulin resistance (IR). | 24167361 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We described, for the first time, an inverse association between serum ferritin and sTfR with osteocalcin and extend previous results on adiponectin, thus supporting that factors related to iron metabolism could contribute to the insulin resistance and the development of type 2 diabetes mellitus. | 24167545 |
| Inflammation, Haiti | Deregulated Nutrient Sensing | HT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT. | 24170558 |
| Haiti | Deregulated Nutrient Sensing | HT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters. | 24170558 |
| Inflammation, Haiti | Deregulated Nutrient Sensing | These results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT. | 24170558 |
| Kidney Failure, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | We describe the prevalence of dyslipidaemia, and potential determinants associated with lipid measures in a large cohort of paediatric ESRD patients. | 24170813 |
| palladium, HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidaemia was 85.1% in peritoneal dialysis (PD) patients, 76.1% in haemodialysis (HD) patients and 55.5% among renal allograft recipients. | 24170813 |
| Kidney Failure, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia is common among paediatric ESRD patients in Europe. | 24170813 |
| Dyslipidemias | Deregulated Nutrient Sensing | Although lipid levels generally improve after transplantation, dyslipidaemia may persist due to decreased graft function, high BMI or to the use of certain immunosuppressants. | 24170813 |
| Premature Menopause, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Considering the known risk factors in women, dyslipidemia, premature menopause, hypertension, oral contraceptives, diabetes and smoking were regarded as the most common ones. | 24171269 |
| Neoplasms | Deregulated Nutrient Sensing | The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase. | 24171924 |
| Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | Older age, female sex, overweight or obese, high wealth index and positive family history of diabetes were significantly associated with insulin resistance. | 24172217 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Participants with type-2 diabetes or insulin resistance had significantly poorer physical health only if they had associated cardiovascular disease. | 24172217 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | When lipid categories, hs-CRP, BMI, and insulin resistance levels were taken into account, testosterone lost its significance in predicting MetS (p < 0.20), suggesting that these markers possess a mediating effect. | 24172696 |
| Glucose Intolerance (disease), diabetic | Deregulated Nutrient Sensing | The patients were divided on the basis of diabetic criteria for glucose intolerance into 2 groups: the diabetic group (n = 105) and nondiabetic group (n = 400). | 24173020 |
| PANCREATIC LIPASE DEFICIENCY | Deregulated Nutrient Sensing | The unimolecular dual incretins corrected two causal mechanisms of diabesity, adiposity-induced insulin resistance and pancreatic insulin deficiency, more effectively than did selective mono-agonists. | 24174327 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Whether decreased oxidative capacity itself is a cause or consequence of insulin resistance and diabetes is unknown. | 24176820 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Increased expression of 11beta-HSD 1 in adipose tissue promotes higher body mass index (BMI), insulin resistance, hypertension, and dyslipidemia. | 24182335 |
| Thrombus, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is a clinical condition with a relatively high prevalence in the population and has been associated with an increased thrombotic risk. | 24183115 |
| Thrombosis, Dyslipidemias, vinyltriethoxysilane | Deregulated Nutrient Sensing | Our study confirmed the association between dyslipidemia and VTE and showed a risk of thrombosis nearly 4 times higher in individuals with this disease. | 24183115 |
| Breast Carcinoma | Deregulated Nutrient Sensing | We sought to evaluate the seven sirtuin family members (SIRT1-7) in a human breast cancer cohort, in relation to clinico-pathological features and outcome of the disease. | 24183459 |
| Mammary Neoplasms | Deregulated Nutrient Sensing | Immunohistochemical analysis of SIRT1-7 protein levels was undertaken in 392 oestrogen receptor (ER+ve) and 153 ER-ve breast tumour samples. | 24183459 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | However the role of SIRT1 and SOST in OA Ob remains unknown. | 24184155 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Herein, we explored the role played by SIRT1 and SOST on the abnormal mineralization and cWnt signaling in OA Ob. | 24184155 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | SIRT1 expression was significantly reduced in OA Ob compared to normal yet not modified by TGF-b1. | 24184155 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Specific inhibition of SIRT1 increased TGF-b1 and SOST expressions in OA Ob, while stimulating SIRT1 activity with b-Nicotinamide mononucleotide reduced the expression of TGF-b1 and SOST, and increased mineralization in OA Ob. | 24184155 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | These data indicate that high level of SOST is responsible, in part, for the reduced cWnt and mineralization of human OA Ob, which in turn is linked with abnormal SIRT1 levels in these pathological cells. | 24184155 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/b-catenin activity. | 24184155 |
| Pre-Eclampsia | Deregulated Nutrient Sensing | A randomized controlled clinical trial investigating the effect of calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress and insulin resistance in pregnant women at risk for pre-eclampsia. | 24187901 |
| Pre-Eclampsia | Deregulated Nutrient Sensing | Increased levels of pro-inflammatory factors, markers of oxidative stress and insulin resistance during pregnancy have been associated with the development of pre-eclampsia. | 24187901 |
| Pre-Eclampsia | Deregulated Nutrient Sensing | To our knowledge, no reports are available indicating the effects of consumed calcium supplement plus aspirin on high sensitivity C-reactive protein (hs-CRP), oxidative stress parameters and insulin resistance in pregnant women at risk for pre-eclampsia. | 24187901 |
| Pre-Eclampsia | Deregulated Nutrient Sensing | This study was designed to investigate the effects of consumed calcium supplement plus low-dose aspirin on hs-CRP, oxidative stress parameters and insulin resistance among Iranian pregnant women at risk for pre-eclampsia. | 24187901 |
| Metabolic Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is a common metabolic disorder that may result from abnormalities in the synthesis, processing and catabolism of lipoprotein particles. | 24188362 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | At baseline, 774 (33%) had diabetes, 1252 (63%) dyslipidemia, and 1601 (68%) hypertension. | 24189773 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | The prevalences of insulin resistance and MetS were calculated. | 24190050 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | WC was associated with incident insulin resistance and MetS independent of BMI in both men and women. | 24190050 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Normal-weight individuals with insulin resistance and/or MetS are not rare in the Chinese population. | 24190050 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Fat mass is associated with insulin resistance and MetS in normal-weight subjects. | 24190050 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | Therefore, we investigated the association between serum AFP and insulin resistance in patients with CHC. | 24190142 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | Whole-body insulin resistance is associated with an elevated serum AFP level in patients with CHC. | 24190142 |
| Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | Lifestyle interventions targeting insulin resistance can reduce the serum AFP level and may ameliorate the clinical course of CHC. | 24190142 |
| Periodontal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The goal of this study was to explore whether insulin resistance and beta cell function are related to periodontal pocket formation, indicative of infectious periodontal disease in non-smoking adults without manifest diabetes. | 24192072 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Further research is needed to determine how racial/ethnic differences in dyslipidemia affect racial/ethnic differences in cardiovascular disease rates. | 24192801 |
| Dyslipidemias, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | The most prevalent associated cardiovascular risk factors in the total population were smoking (24.9%), dyslipidemia (16.4%), a family history of premature cardiovascular disease (15.9%), and obesity (7.4%). | 24192846 |
| Humoral immune defect, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes results from combined insulin resistance and b-cell deficiency. | 24193809 |
| Renal Insufficiency, Dyslipidemias, Chronic Kidney Diseases, Atherosclerosis | Deregulated Nutrient Sensing | In addition, because dyslipidemia facilitates atherosclerosis and renal dysfunction, antihyperlipidemic treatment is important to prevent cardiac and renal events in CKD patients. | 24198051 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effect of a randomised controlled vitamin D trial on insulin resistance and glucose metabolism in patients with type 2 diabetes mellitus. | 24198221 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Individuals in the 5th quintile or higher of resistin (RQ5) were younger (P<0.001) and had a lower prevalence of arterial hypertension (P<0.001), abdominal obesity (P<0.001), diabetes (P<0.001) and dyslipidemia (P<0.001). | 24201007 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Low-grade inflammation in adipose tissue and liver has been implicated in obesity-associated insulin resistance and type 2 diabetes. | 24203314 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In all, 8, 20, 16, and 9 patients had diabetes mellitus, hypertension, dyslipidemia, and smoking habit, respectively. | 24203346 |
| Astrocytoma, Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. | 24203892 |
| Neoplasms | Deregulated Nutrient Sensing | Here we further evaluate the role of the mTORC1/mTORC2 pathway in order to better direct pharmacologic blockade in these common childhood tumors. | 24203892 |
| Optic Disk, Dyslipidemias, Diabetes Mellitus, Cataract, Retinal Vein Occlusion | Deregulated Nutrient Sensing | It was not significantly associated with optic nerve head measurements, refractive error, any ocular biometric parameter, nuclear cataract, early age-related macular degeneration and retinal vein occlusion, diabetes mellitus, smoking, and dyslipidemia. | 24204672 |
| Dyslipidemias | Deregulated Nutrient Sensing | First-line management of dyslipidemia among very-high cardiovascular risk outpatients in Western Greece is unsatisfactory, with the majority of treated individuals failing to attain the LDL-C and non-HDL-C targets. | 24209409 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | In obese patients with uncomplicated dyslipidemia and hypertension, plasma S1P was increased compared with that in nonobese and lean individuals. | 24212262 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Effect of laparoscopic Roux-en-Y gastric bypass on body composition and insulin resistance in Chinese patients with type 2 diabetes mellitus. | 24214201 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events. | 24215618 |
| Dyslipidemias, Cerebrovascular accident, Myocardial Ischemia, diabetic | Deregulated Nutrient Sensing | The risk factors for ischemic heart disease (IHD) or cerebrovascular accident (CVA) in elderly diabetic individuals with type IIb dyslipidemia are not fully known. | 24215618 |
| Dyslipidemias, Cerebrovascular accident, Myocardial Ischemia, diabetic | Deregulated Nutrient Sensing | Therefore, we investigated the relationship between lipid levels and IHD and CVA in diabetic individuals with type IIb dyslipidemia. | 24215618 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | High-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol/HDL-C were significantly associated with the risk of cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <65 years, and HDL-C and diastolic blood pressure was significantly associated with cardiovascular events in patients aged 65-74 years. | 24215618 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Multiple regression analysis showed that lower HDL-C was significantly associated with the risk of cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <65 years and 65-74 years. | 24215618 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Lower HDL-C was an important risk factor for cardiovascular events in diabetic individuals with type IIb dyslipidemia who were aged <75 years. | 24215618 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. | 24215793 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of a-cells are potential contributors to the b-cell compensatory response to insulin resistance in the absence of overt diabetes. | 24215793 |
| Dyslipidemias | Deregulated Nutrient Sensing | Low vitamin D levels correlate with dyslipidemia, but limited data exist on indigenous children. | 24217313 |
| Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with pre-diagnosed metabolic disorders, especially dyslipidemia and type 2 diabetes, should undergo regular controls of serum triglycerides during tamoxifen treatment. | 24221976 |
| Metabolic Diseases, Dyslipidemias | Deregulated Nutrient Sensing | However, the awareness rate of cardiometabolic diseases was low, especially for dyslipidemia. | 24222736 |
| Nonalcoholic Steatohepatitis, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver Disease | Deregulated Nutrient Sensing | Patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) often have metabolic disorders including insulin resistance and type 2 diabetes mellitus (T2DM). | 24223115 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | The proportion of patients with T2DM significantly gradually increased, HbA1c and the homeostasis model assessment of insulin resistance were significantly elevated, and 1,5-anhydroglucitol (1,5-AG) was remarkably decreased with the progression of fibrosis. | 24223115 |
| Dyslipidemias | Deregulated Nutrient Sensing | Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients. | 24223837 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Similar results were obtained in each subgroup of patients with hypertension, dyslipidemia, or diabetes mellitus. | 24225305 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | The ameliorating effect of a-GI on post-prandial hyperglycemia without stimulating insulin secretion may improve atherogenic dyslipidemia by reducing insulin resistance. | 24225338 |
| Hyperglycemia | Deregulated Nutrient Sensing | Rice and noodle consumption is associated with insulin resistance and hyperglycaemia in an Asian population. | 24229726 |
| Hyperglycemia, Inflammation | Deregulated Nutrient Sensing | These results suggest that high consumption of rice and noodles may contribute to hyperglycaemia through greater insulin resistance and that this relationship is independent of adiposity and systemic inflammation. | 24229726 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Influence of early enteral nutrition (EEN) on insulin resistance in gastric cancer patients after surgery. | 24231013 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | To evaluate the benefits of reducing insulin resistance by early enteral nutrition (EEN) in gastric cancer patients after surgery. | 24231013 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | The management of EEN can alleviate insulin resistance in gastric cancer patients with surgical treatment. | 24231013 |
| Obesity, Abdominal, Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hyperuricemia is prevalent in Chinese T2DM patients with central obesity and is significantly positively associated with women, cardiovascular risk factors such as obesity, hypertension and dyslipidemia, and low eGFR. | 24231020 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children. | 24232638 |
| Neoplasms | Deregulated Nutrient Sensing | We suggest that these tumours may arise through a mechanism involving ATP depletion, activation of AMPK, and induction of cyclin D1, and that this may be a unique pathway of tumour development that has the potential for therapeutic intervention in these rare tumours. | 24236567 |
| Obesity | Deregulated Nutrient Sensing | In animal studies, monosodium glutamate (MSG) intake at a particular age has been found to increase the risk of insulin resistance and obesity. | 24238788 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | Multiple logistic regression analysis showed that the largest risk factor for ACS development was given by smoking (11.88-fold increased risk), hypertension (4.32-fold increased risk), type II diabetes (3.44-fold increased risk), gender (2.32-fold increased risk), and dyslipidemia (1.52-fold increased risk). | 24239012 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Only one patient had diabetes and 10 (15.4%) had dyslipidemia. | 24239395 |
| Dyslipidemias, Obesity, Behavior Disorders | Deregulated Nutrient Sensing | Measures aimed at combating obesity and other lifestyle-related risk factors are also vital for effectively controlling dyslipidaemia and reducing the burden of CVD. | 24240385 |
| Dyslipidemias | Deregulated Nutrient Sensing | Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol. | 24240543 |
| TG gene, Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Atherogenic dyslipidemia characterized by abnormal changes in plasma lipid profile such as low high-density lipoprotein (HDL) and increased triglyceride (TG) levels is strongly associated with atherosclerotic diseases. | 24240543 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | SIRT1 and AMPK mediate hypoxia-induced resistance of non-small cell lung cancers to cisplatin and doxorubicin. | 24240701 |
| Metabolic Diseases, Primary malignant neoplasm | Deregulated Nutrient Sensing | Although SIRT1 contributes to aging and metabolic disorders, its role in cancer progression and therapeutic responses remains controversial. | 24240701 |
| Non-Small Cell Lung Carcinoma, Hypoxia | Deregulated Nutrient Sensing | SIRT1 was downregulated in a panel of non-small cell lung carcinoma (NSCLC) cells exposed to hypoxia for 48 hours. | 24240701 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The shortest distance in the receiver operating characteristic curves for hypertension, dyslipidemia, diabetes, or >= 2 of these risk factors suggested a BMI cutoff of 26 and a waist circumference cutoff of 90 cm for both men and women. | 24244645 |
| atherosclerotic | Deregulated Nutrient Sensing | Ambulatory blood pressure parameters in office normotensive obese and non-obese children: relationship with insulin resistance and atherosclerotic markers. | 24247272 |
| Kidney Diseases | Deregulated Nutrient Sensing | The up-regulated mTOR activity (limited to mTORC1 branch) in all glomerular and tubular epithelia from both transplant and native biopsies indicates that the activated mTOR signaling is a general phenomenon in variants of progressing renal diseases and may be used as a marker of active renal disease states. | 24247793 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Reports on the association between hypertension and insulin resistance have been inconsistent even though most studies show a definite association. | 24250303 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | It is also not certain if the association between insulin resistance and hypertension applies to all populations. | 24250303 |
| Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | To determine the prevalence of insulin resistance in hypertensive Nigerians and to examine the association of insulin resistance with hypertension and some anthropometric indices. | 24250303 |
| Antihypertensive Agents | Deregulated Nutrient Sensing | The hypertensives we studied had a higher occurrence of insulin resistance compared to the normotensives. | 24250303 |
| Hypertensive (finding), Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | This makes it necessary for persons with hypertensive to have regular screening for diabetes and other categories of glucose intolerance as the increased insulin increases their risk of developing type 2 diabetes mellitus. | 24250303 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Serum levels of cytokines and chemokines associated with cardiovascular disease in Brazilian patients treated with statins for dyslipidemia. | 24252254 |
| Inflammation, Hyperemia, Atherosclerosis | Deregulated Nutrient Sensing | Pulse wave velocity of the aorta (PWV), brachial artery flow mediated dilatation (FMD), nitroglycerin mediated dilatation (NMD), microvascular endothelial function (reactive hyperemia index [RHI]), and circulating biomarkers of inflammation, insulin resistance, and atherosclerosis risk all were quantified. | 24252844 |
| Dyslipidemias, Alcoholic Intoxication, Chronic, Diabetes Mellitus | Deregulated Nutrient Sensing | High blood pressure (22%), smoking (9*1%), alcoholism (10*8%), dyslipidemia (8*7%), and diabetes mellitus (5*4%) were the most common risk factors. | 24256161 |
| Dyslipidemias, Alcoholic Intoxication, Chronic | Deregulated Nutrient Sensing | High blood pressure (28*4%), dyslipidemia (20*8%), and alcoholism (17*0%) were the most common risk factors. | 24256161 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The High level of uric acid status in vivo appeared closely related to HOMA-IR, which could further promote the progress of pre-diabetic patients to diabetes and causing dyslipidemia. | 24257178 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition to worsening control of diabetes and dyslipidemia, severe NAFLD was confirmed. | 24259612 |
| Toxic effect | Deregulated Nutrient Sensing | A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. | 24261972 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients receiving antipsychotic had higher prevalence of obesity (16.9% vs. 11.9%), smoking (22.2% vs. 11.1%), diabetes mellitus (16% vs. 11.9%), and dyslipidemia (32.8% vs. 25.8%) (p < 0.001). | 24265143 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Treatment potential for dyslipidaemia management in patients with coronary heart disease across Europe: findings from the EUROASPIRE III survey. | 24267243 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidaemia is among the most important risk factors for coronary heart disease (CHD). | 24267243 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Although management of dyslipidaemia in CHD patients is improving, a large majority of CHD patients with dyslipidaemia is still inadequately treated and many patients on lipid-lowering therapy are not reaching the treatment goals. | 24267243 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Therefore, a considerable potential still exists throughout Europe to reduce CHD mortality and morbidity rates through better treatment of dyslipidaemia. | 24267243 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Furthermore, subjects with NAFLD had higher prevalence of diabetes, pathological waist-circumference, insulin-resistance and positive ATP-III criteria. | 24268461 |
| Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | While NAFLD had only a borderline significant association with higher end-diastolic thicknesses of left-ventricle posterior wall (edPW) and right-ventricle wall, higher values of edPW and end-diastolic thickness of interventricular septum were significantly correlated with glucose levels above 100mg/dl, hypertension, MS and insulin-resistance. | 24268461 |
| Arterial Stiffness, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | An increase in the EPA/AA ratio is associated with improved arterial stiffness in obese patients with dyslipidemia. | 24270918 |
| Arterial Stiffness, Inflammation, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These findings suggest that EPA improves the arterial stiffness in association with an increase in the EPA/AA ratio and a decrease in inflammation in obese patients with dyslipidemia. | 24270918 |
| Autonomic neuropathy, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. | 24270983 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Hematopoietic Sirt1 KO mimicked the diabetic mobilization defect, whereas hematopoietic Sirt1 overexpression in diabetes rescued defective mobilization and vascular repair. | 24270983 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Through p66Shc and Sirt1, diabetes and sympathectomy elevated the expression of various adhesion molecules, including CD62L. | 24270983 |
| Autonomic neuropathy, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, autonomic neuropathy in the BM impairs stem cell mobilization in diabetes with dysregulation of the life-span regulators p66Shc and Sirt1. | 24270983 |
| Overweight | Deregulated Nutrient Sensing | In conclusion, autonomic nervous system activity was associated with cardiorespiratory fitness, insulin resistance, and SBP in overweight and obese adolescents. | 24272169 |
| Dyslipidemias, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | Prevalence of dyslipidaemia in patients with renal cell carcinoma: a case-control study in China. | 24274674 |
| Refractory Cytopenia of Childhood, Dyslipidemias, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | To examine the prevalence of dyslipidaemia in patients with renal cell carcinoma (RCC) in a Chinese population. | 24274674 |
| Dyslipidemias | Deregulated Nutrient Sensing | The lipid profiles were defined as 'normal', 'borderline high', 'high' and 'low' according to Chinese Guidelines on Adult Dyslipidaemia. | 24274674 |
| Dyslipidemias, Hypertension, CTCAE, Dilated Cardiomyopathy Pathway, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | FMR patients had lower rates of hypertension and dyslipidemia, but higher rates of dilated cardiomyopathy, atrial fibrillation, and New York Heart Association functional class III/IV. | 24275908 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was present in 65.7% (hypertriglyceridemia, 45.3%; increased low-density lipoprotein cholesterol, 37.5%; decreased high density lipoprotein cholesterol, 19.5%) of patients. | 24277052 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent manner. | 24278101 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Our data suggest that resveratrol inhibits gastric cancer in a Sirt1-dependent manner and provide detailed evidence for the possibility of applying resveratrol in gastric cancer prevention and therapy. | 24278101 |
| Dyslipidemias, EQ-5D-5L - Anxiety or Depression | Deregulated Nutrient Sensing | High blood pressure, dyslipidemia and anxiety/depression symptoms showed a mild correlation with the total score of symptoms (multiple R2 =0.18, p < 0.001). | 24279682 |
| Dyslipidemias, Vestibular Diseases, EQ-5D-5L - Anxiety or Depression | Deregulated Nutrient Sensing | High blood pressure, dyslipidemia and anxiety/depression symptoms may have a mild influence on the report of symptoms of vestibular disease in both, patients and control subjects. | 24279682 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity, dyslipidaemia, and family history of diabetes were positively associated with both undiagnosed and diagnosed type 2 diabetes. | 24282548 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Metabolic syndrome is prevalent in adults characterized by increased visceral adiposity and insulin resistance (IR). | 24283920 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Compared to those with normal glucose tolerance, visceral fat and IR were higher and b-cell function was lower in adults with glucose intolerance and type 2 diabetes mellitus. | 24283920 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | [Impact of insulin resistance on prognosis in non-diabetic patients with acute coronary syndromes]. | 24284181 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | To evaluate the impact of insulin resistance (IR) on prognosis in non-diabetic acute coronary syndrome patients. | 24284181 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | Increased insulin resistance is linked with poor prognosis of non-diabetic patients with acute coronary syndrome. | 24284181 |
| Hyperglycemia | Deregulated Nutrient Sensing | Anesthetic-induced transient hyperglycemia and insulin resistance do not depend on the sympathoadrenal axis. | 24285105 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Crosstalk between inflammatory signaling pathways and insulin signaling pathways causes metabolic insulin resistance and endothelial dysfunction. | 24285449 |
| Dyslipidemias | Deregulated Nutrient Sensing | Cardiac transplant patients are at risk for developing cardiac allograft vasculopathy, and dyslipidemia in this patient population has been associated with increased risk. | 24285762 |
| Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Type 2 DM, IFG, mixed dyslipidemia, hypertriglyceridemia, HDL-hypocholesterolemia, and LDL-hypercholesterolemia predominated in low-risk asymptomatic, while only LDL-hypercholesterolemia prevailed also in symptomatic PHPT. | 24287796 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Type II of dyslipidemia was typical for multifocal and coronary atherosclerosis, type IV was typical for brachiocephalic arteries. | 24288749 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Variants of dyslipidemias were studied in 78 patients with atherosclerosis of various localizations. | 24288749 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Low levels of serum 25-hydroxy vitamin D [25(OH)D], as a marker of vitamin D deficiency, have been linked to a wide field of health problems, including metabolic diseases such as insulin resistance, type 1 and type 2 DM. | 24290086 |
| Overweight | Deregulated Nutrient Sensing | The prevalence of insulin resistance in normal-weight, overweight, and obese subjects were 4.7%, 25.6%, and 47.1% respectively. | 24290751 |
| Metabolic Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) is a common metabolic disorder in chronic kidney disease patients. | 24292690 |
| Dyslipidemias, Diabetes Mellitus, Hypothyroidism | Deregulated Nutrient Sensing | Patients within the area covered by HoBtPCT (England) prescribed medication for dyslipidaemia, type-2 diabetes and hypothyroidism, between 2000 and 2010 inclusively. | 24293338 |
| Dyslipidemias, Diabetes Mellitus, Hypothyroidism | Deregulated Nutrient Sensing | Using data from GP prescribing systems, a computerised tool to calculate individual adherence levels for oral pharmacotherapy for the treatment of diabetes, dyslipidaemia and hypothyroidism has been developed. | 24293338 |
| Hyperglycemia, Steroid-induced myopathy | Deregulated Nutrient Sensing | Hyperglycemia was determined without any clinical sign and metformin was started for steroid-induced insulin resistance. | 24296614 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin resistance and chronic low-grade inflammation. | 24302564 |
| Periodontitis | Deregulated Nutrient Sensing | Association between insulin resistance and periodontitis in Korean adults. | 24303984 |
| Periodontitis | Deregulated Nutrient Sensing | We investigated the association between insulin resistance and periodontitis among Korean adults. | 24303984 |
| Periodontitis | Deregulated Nutrient Sensing | Moreover, obese post-menopausal women showed an increased association between insulin resistance and periodontitis (adjusted OR, 1.92; 95% CI,1.29-2.87). | 24303984 |
| Periodontitis, Obesity | Deregulated Nutrient Sensing | Our results suggest that insulin resistance may be associated with periodontitis, especially when combined with obesity, among post-menopausal women in Korea. | 24303984 |
| Dyslipidemias | Deregulated Nutrient Sensing | Apolipoprotein A-V level may contribute to the development of obesity-associated dyslipidemia. | 24304484 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Insulin may be a potent regulator of serum apoA-V level in obesity, and apoA-V level may partly contribute to the development of obesity-associated dyslipidemia. | 24304484 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | Thus, we investigated the association between apoA-V levels and dyslipidemias in obese children with hyperinsulinemia. | 24304484 |
| Thrombus, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | OML test is a safe diagnostic procedure in patients with previous thrombotic events (and with the consequent associated risk factors such as diabetes mellitus or dyslipidemia) and in healthy subjects. | 24304733 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Overall, the <= 5- or >= 9-hour sleep duration, poor-quality sleep and high-SRBD risk are related with the high prevalence of MetS, perhaps through elevated insulin-resistance resulting from adiposity. | 24305464 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. | 24308215 |
| Williams Syndrome | Deregulated Nutrient Sensing | These data suggest that protein aggregation plays a role in the development of WS phenotypes and that the mammalian target of rapamycin complex 1 pathway is a potential therapeutic target of WS. | 24308646 |
| Diabetes Mellitus, Non-Insulin-Dependent, Erectile dysfunction | Deregulated Nutrient Sensing | The association between testosterone deficiency and insulin resistance in men with type 2 diabetes is well established and current endocrine society guidelines recommend the measurement of testosterone levels in all men with type 2 diabetes or erectile dysfunction. | 24308723 |
| Structure of beta Cell of islet | Deregulated Nutrient Sensing | Research in renal transplant recipients has suggested that pancreatic b-cell dysfunction, as opposed to insulin resistance, may be the key pathologic process. | 24309190 |
| Autonomic nervous system disorders | Deregulated Nutrient Sensing | The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance. | 24309597 |
| insensitivity | Deregulated Nutrient Sensing | Tunicamycin-induced ER stress in adipocytes can trigger autophagic response and insulin insensitivity that was partially attributed to the upregulation of IRE1-JNK pathway, whereas autophagy deficiency resulted in ER stress and impaired insulin signaling, further supporting the crucial roles of autophagy in ER stress and insulin resistance. | 24309597 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, our results demonstrated a reciprocal functional interaction among autophagy, ER stress, and insulin signaling in adipose tissue of type 2 diabetes and adipocytes, supporting an adaptive role of autophagy-dependent mechanism in response to ER stress-induced insulin resistance in type 2 diabetes. | 24309597 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is present at the muscle mitochondrial level, and is not affected by reducing circulating NEFAs in type 2 diabetes. | 24310562 |
| Sleeplessness, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The associations of insomnia with hypertension and dyslipidaemia, the main modifiable cardiovascular risk factors, are less studied. | 24313664 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | We especially lack understanding on the longitudinal effects of insomnia on dyslipidaemia. | 24313664 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular diseases are a major cause of morbidity and mortality in India, with dyslipidemia contributing significantly to the risk. | 24314364 |
| Dyslipidemias, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Using the logistic regression model, we found age, hypertension, alcohol consumption, and abdominal obesity to be associated with increased odds of dyslipidemia. | 24314364 |
| Weight decreased, Diabetes Mellitus | Deregulated Nutrient Sensing | There is an association of the A allele with an improvement of insulin resistance secondary to weight loss after liraglutide treatment in obese patients with diabetes mellitus type 2. | 24322329 |
| Breast Carcinoma, Obesity | Deregulated Nutrient Sensing | Resistin, a gene that is linked to obesity, insulin resistance, and breast cancer, was expressed more than four times higher in AA tumors. | 24324792 |
| Cessation of life, Structure of beta Cell of islet | Deregulated Nutrient Sensing | Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic b-cell dysfunction and death in vitro. | 24325467 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Association between insulin resistance and low relative appendicular skeletal muscle mass: evidence from a cohort study in community-dwelling older men and women participants. | 24325896 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | It has been hypothesized that insulin resistance plays a role in the development of the loss of skeletal muscle; however, no cohort studies on insulin resistance and low relative appendicular skeletal muscle mass (ASM) have been published to date. | 24325896 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Obese patients were younger and more likely to have hypertension, diabetes mellitus, and dyslipidemia than normal or underweight patients. | 24326936 |
| Hepatitis C | Deregulated Nutrient Sensing | Hepatitis C virus (HCV) induces insulin resistance, which improves upon viral clearance. | 24329983 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The FTO rs1421085 T>C polymorphism may modulate the magnitude of dyslipidemia in Chinese early-onset obesity. | 24331679 |
| Inflammation, Periodontitis, diabetic | Deregulated Nutrient Sensing | Chronic inflammation of periodontitis aggravates glycemic control in type 2 diabetic patients through aggravation of insulin resistance. | 24331774 |
| Tumor necrosis | Deregulated Nutrient Sensing | Increased or decreased release of various inflammatory mediators, such as high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-a, interleukin (IL)-6 and adipokines, such as adiponectin, leptin, and resistin, are presumed to be responsible for developing and progressing insulin resistance. | 24331774 |
| Glucose Intolerance (disease), Liver carcinoma, Haploinsufficiency | Deregulated Nutrient Sensing | NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. | 24332041 |
| Neoplasms, Dysplasia, Fatty degeneration, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Tumor development is preceded by increased interleukin-6 (IL-6) expression, early-onset glucose intolerance, and progressive steatosis and dysplasia in livers. | 24332041 |
| Glucose Intolerance (disease), FAM126A gene | Deregulated Nutrient Sensing | Blockading IL-6 overexpression averts glucose intolerance and partially deters HCC development. | 24332041 |
| Glucose Intolerance (disease), Neoplasms, FAM126A gene | Deregulated Nutrient Sensing | These findings suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression. | 24332041 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Zinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. | 24335710 |
| Overweight | Deregulated Nutrient Sensing | Interaction analysis showed that children who were overweight and obese who also had low concentrations of vitamin A had higher CRP and lower triglycerides (p < 0.1), children with low vitamin E had significantly lower glucose and triglycerides (p < 0.1) and higher low-density lipoprotein (LDL) concentrations (p < 0.05), and children with low zinc concentrations had higher insulin resistance compared with children with adequate weight (p < 0.05). | 24335710 |
| Inflammation, Overweight | Deregulated Nutrient Sensing | Furthermore, low concentrations of zinc, vitamins A and E in children who were overweight and obese were associated with lipids, inflammation and insulin resistance. | 24335710 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Associations between seven SULF2 tagSNPs and TG levels were assessed in 210 obese T2DM subjects with dyslipidemia. | 24339435 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These findings implicate SULF2 as potential therapeutic target in the atherogenic dyslipidemia of obesity and T2DM. | 24339435 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Similar partial correlations controlling for age, gender, hypertension, smoking, dyslipidemia and ejection fraction remained significant. | 24340842 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These data indicates a small contribution of epsilon4 polymorphism in heterozygous form to the development of dyslipidemia in obesity. | 24340925 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | [Lipid, adipokine and ghrelin concentrations in myocardial infarction patients with insulin resistance]. | 24340956 |
| Dyslipidemias, Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | Predilection role diabetes mellitus and dyslipidemia in the onset of ischemic stroke. | 24341059 |
| Dyslipidemias, atherosclerotic, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus as permanently elevated blood glucose, often accompanied by dyslipidemia, is among the leading causes of atherosclerotic alteration in blood vessels and is also increasing in the world. | 24341059 |
| Dyslipidemias, Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the existence and predilection of diabetes mellitus and dyslipidemia, in the development of ischemic stroke. | 24341059 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Cerebrovascular accident | Deregulated Nutrient Sensing | Diabetes mellitus and dyslipidemia, along with hypertension and smoking are the leading risk factors for the occurrence of stroke. | 24341059 |
| Dyslipidemias, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | A single-nucleotide polymorphism in the proximal promoter region of the apolipoprotein M gene is associated with dyslipidaemia but not increased coronary artery diseases in Chinese populations. | 24341666 |
| Dyslipidemias | Deregulated Nutrient Sensing | The results presented here suggest that the rs805297 SNP is not associated with an increased risk of developing CAD, although it does independently correlate with dyslipidaemia in Han Chinese individuals. | 24341666 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Drug-related problems in type 2 diabetes mellitus patients with dyslipidemia. | 24341672 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, few studies have been performed on T2DM patients with dyslipidemia. | 24341672 |
| Dyslipidemias | Deregulated Nutrient Sensing | The retrospective study involved 208 T2DM in-patients and out-patients with dyslipidemia, and was conducted at a tertiary hospital in Malaysia from January 2009 to December 2011. | 24341672 |
| Dyslipidemias | Deregulated Nutrient Sensing | The majority of T2DM patients with dyslipidemia (91.8%) had at least one DRP. | 24341672 |
| Renal Insufficiency, DENR protein, human, Dyslipidemias | Deregulated Nutrient Sensing | Male gender, renal impairment, polypharmacy and poor lipid control were factors that were significantly associated with DRP in diabetic dyslipidemia patients. | 24341672 |
| Dyslipidemias | Deregulated Nutrient Sensing | Early identification of DRPs and factors associated with them are essential to prevent and resolve DRPs in T2DM patients with dyslipidemia. | 24341672 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia prevalence was higher among Uygur (54.3%), and diabetes prevalence was higher among Hans (7.1%). | 24341701 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Psychological insulin resistance in geriatric patients with diabetes mellitus. | 24341962 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the extent to which geriatric patients with diabetes mellitus experience psychological insulin resistance (PIR). | 24341962 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Higher coffee and green tea consumption has been suggested to decrease risk of type 2 diabetes, but their roles in insulin resistance (IR) and insulin secretion remain unclear. | 24342074 |
| Chronic Obstructive Airway Disease, physiopathological | Deregulated Nutrient Sensing | Insulin resistance may contribute to vascular dysfunction in patients with chronic obstructive pulmonary disease. | 24343042 |
| Breast Carcinoma | Deregulated Nutrient Sensing | There was no statistically significant difference in the prognostic factors of breast cancer at the time of diagnosis between 33 patients with insulin resistance and 38 patients without insulin resistance. | 24344007 |
| Thrombosis | Deregulated Nutrient Sensing | These findings provide new insight into the mechanisms to explain the heightened risk for thrombosis in adults with insulin resistance/diabetes. | 24344794 |
| Hyperphagia, Obesity | Deregulated Nutrient Sensing | Short sleep duration induces hormonal perturbations contributing to hyperphagia, insulin resistance, and obesity. | 24347344 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Arterial hypertension and dyslipidemia are modifiable cardiovascular risk factors. | 24348044 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The objective of this study was to determine the pattern and prevalence of dyslipidemia in newly presenting Nigerians with arterial hypertension, as well as determine some of its correlates. | 24348044 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The most common dyslipidemia was low HDL-C, found in both the hypertensive (44.3%) and normotensive (20.9%) patients. | 24348044 |
| Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | The prevalence of dyslipidemia in hypertensives and controls was 64% and 39%, respectively. | 24348044 |
| Inflammation, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Chronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system. | 24348043 |
| metabolic disturbance | Deregulated Nutrient Sensing | Resistance to insulin actions is contributing to many metabolic disturbances. | 24348155 |
| Diabetic Nephropathy, Diabetic Angiopathies | Deregulated Nutrient Sensing | Deregulation of miR-29 is involved in the pathogenesis of diabetic nephropathy and insulin resistance thus may be implicated in diabetic vascular complication. | 24349318 |
| Dyslipidemias, atherosclerotic, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Atherosclerotic risk factors included hypertension (16%), diabetes mellitus (24%), and dyslipidemia (28%). | 24350411 |
| Dyslipidemias, Diabetic Angiopathies | Deregulated Nutrient Sensing | These results strengthen the rationale for studying dyslipidemia treatment to prevent diabetic microvascular disease. | 24352521 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The association between testosterone deficiency and insulin resistance in men with type 2 diabetes is well established. | 24355040 |
| Dysglycemia | Deregulated Nutrient Sensing | The D2 Ala92Ala genotype is associated with reduced placental D2 activity but is not associated with dysglycemia, increased insulin resistance, or worse gestational outcomes. | 24355051 |
| Hypercholesterolemia, Glucose Intolerance (disease), Chronic Obstructive Airway Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no significant difference in prevalence of other comorbidities (diabetes, glucose intolerance, hypercholesterolaemia, chronic renal and chronic obstructive pulmonary disease) between studied groups (p > 0.05). | 24355081 |
| Dyslipidemias | Deregulated Nutrient Sensing | Bilateral reductions in parental longevity are linked to unfavorable cardiometabolic phenotype in T2DM descendants, with worsened insulin resistance and atherogenic dyslipidemia among 1st-degree offspring. | 24355662 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence and severity of atherogenic dyslipidemia were raised in [SLF &/or SLM], by 53% (prevalence) and 13% (log[TG]/HDL-C) (p 0.0172 and p 0.0067). | 24355662 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Despite the high percentage of drug prescription, hypertension and dyslipidemia were not fully controlled. | 24356735 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | At logistic regression analyses; age, diabetes, hypertension, dyslipidemia, cardiovascular disease, obesity and lower income were found to be independent predictors for increased prevalence of MPD. | 24357639 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance confers risk for diabetes mellitus and associates with a reduced capacity of the arterial baroreflex to regulate blood pressure. | 24358272 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our observations may help to characterize the neural pathways by which insulin resistance, and possibly diabetes mellitus, relates to adverse cardiovascular outcomes. | 24358272 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Independent risk factors for SS in patients with AF were age (OR 1.049), hypertension (OR 2.086), dyslipidemia (OR 2.073), and valvular AF (OR 3.157). | 24360776 |
| Inflammation, Dyslipidemias, Abdominal aortic calcification | Deregulated Nutrient Sensing | Osteoprotegerin, inflammation and dyslipidemia are associated with abdominal aortic calcification in non-diabetic patients on peritoneal dialysis. | 24361071 |
| Dyslipidemias, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | Age, length of stay, paroxysmal atrial fibrillation (PAF) and dyslipidemia were independent factors for the AF development. | 24364091 |
| Glucose Intolerance (disease), Tuberculosis | Deregulated Nutrient Sensing | The impact of nutrition and glucose intolerance on the development of tuberculosis in Japan. | 24365558 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The proportion of males with glucose intolerance was significantly higher in TB patients than in controls (34.2% vs. 14.4%). | 24365558 |
| Glucose Intolerance (disease), Malnutrition, Tuberculosis | Deregulated Nutrient Sensing | In Japan, the development of TB is still associated with glucose intolerance and malnutrition. | 24365558 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We calculated the prevalence of atherogenic dyslipidemia by sex, according to several cutoff HDL cholesterol in women, and in the whole sample, and its association with diabetes. | 24365578 |
| Psychotic Disorders | Deregulated Nutrient Sensing | Psychosis has the hallmarks of insulin resistance by at least age 25. | 24367528 |
| Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Interplay of overweight and insulin resistance on hypertension development. | 24370898 |
| Metabolic Diseases, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity and hypertension are associated, possibly through causal pathways involving insulin resistance and metabolic derangements. | 24370898 |
| Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | We aimed to investigate in a whites sample if overweight or obese persons without insulin resistance are at risk of developing hypertension or blood pressure progression. | 24370898 |
| Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | According to this study, being overweight or obese without insulin resistance increases the risk of hypertension and blood pressure progression. | 24370898 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function. | 24372992 |
| vascular inflammations, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Aspirin exhibited no significant dose-dependent effect on markers of vascular inflammation, oxidative stress, insulin resistance and endothelial function (photoplethysmography) when used in type 2 diabetes over a 2-week period. | 24372992 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | [Prevalence and risk factors for dyslipidemia in diabetics with overweight or obesity]. | 24373394 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | To explore the prevalence and risk factors for dyslipidemia in diabetics with overweight or obesity. | 24373394 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Dyslipidemia was detected in 3160/3593 (87.9%) diabetics with overweight or obesity. | 24373394 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The prevalence of dyslipidemia is quite high in diabetics with overweight or obesity. | 24373394 |
| Cardiac complication, Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The controls of blood pressure, serum uric acid level, blood glucose and body weight may reduce the prevalence of dyslipidemia, prevent and delay the development of cardiovascular complications and reduce the mortality of diabetics with overweight or obesity. | 24373394 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Trunk and android fat deposition aggravates insulin resistance, metabolic disorders. | 24373397 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | After multiple stepwise regression analysis, the main influencing factors of lnHOMA-IR and lnHOMA-b were T/B and Grespectively.Logistic regression showed that A (OR = 3.01, 95%CI 1.86-8.17) was a risk factor for diabetes and A/G (OR = 2.71, 95%CI 1.75-6.56) a risk factor for dyslipidemia. | 24373397 |
| Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance, lipid peroxidation and oxidative stress have been identified amongst the possible hits leading to the onset and progression of this disease. | 24373555 |
| Dyslipidemias | Deregulated Nutrient Sensing | Secondary outcome was dyslipidemia [low-density lipoprotein (LDL)>= 100]. | 24374412 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Insulin resistance (IR) is an established risk factor for colorectal cancer (CRC). | 24377587 |
| United States Minor Outlying Islands, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We evaluated UMI as a screening tool for glucose intolerance. | 24377833 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | D-UMI, 2h-UMI and HbA1c levels significantly increased as glucose intolerance worsened. | 24377833 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | 2h-UMI is useful as a non-invasive screening of glucose intolerance. | 24377833 |
| Overweight | Deregulated Nutrient Sensing | Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance. | 24378016 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2g/day extended-release nicotinic acid (ERN), 4g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. | 24378016 |
| Dyslipidemias, Epidemic | Deregulated Nutrient Sensing | [Epidemic features of dyslipidemia among Uygur, Kazakh, and Han adults in Xinjiang, China in 2010]. | 24378138 |
| TG gene, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | However, diabetic patients with severe atherogenic dyslipidemia (LDL-C >=130, TG >=204, and HDL-C <=34 mg/dl) obtained more benefits in terms of HDL-C change after statin therapy. | 24380094 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Diabetic patients, except those with severe atherogenic dyslipidemia, are prone to a decrease in serum HDL-C level after statin treatment, particularly after atorvastatin treatment. | 24380094 |
| Psoriasis, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Systemic disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Recent studies suggest that psoriasis is a systemic disorder associated with cardiovascular disease (CVD) risk factors, such as obesity, hypertension and dyslipidemia. | 24385235 |
| TG gene, CD55 gene | Deregulated Nutrient Sensing | In a large cardiovascular disease-free cohort, NT-proBNP within the lower (physiological) range was inversely associated with TC, LDL-C, TG and insulin resistance with different inflection points, but at higher (pathological) levels these associations were blunted. | 24388001 |
| Pancreatic Neoplasm | Deregulated Nutrient Sensing | Finally, RalGAP suppression caused mTORC1-dependent pancreatic tumor cell invasion. | 24389102 |
| Congenital Heart Defects | Deregulated Nutrient Sensing | Predictors for a metabolically abnormal phenotype (>=3 cardiometabolic abnormalities or insulin resistance) were determined. | 24389519 |
| Inflammation | Deregulated Nutrient Sensing | Serum lipocalin-2, which correlates with inflammation and insulin resistance, may have a direct pathogenic link to disease progression. | 24390241 |
| Dyslipidemias, Lupus Erythematosus, Systemic, Atherosclerosis | Deregulated Nutrient Sensing | In the SLE group, FABP4 was associated with IR, atherogenic dyslipidaemia, as measured by NMR, and the presence of subclinical atherosclerosis. | 24390652 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Association between obesity and therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia. | 24393753 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity is associated with cardiovascular risk factors such as hypertension, dyslipidemia, and diabetes mellitus, as well as cardiovascular diseases. | 24393753 |
| Failure (biologic function), Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Obesity appears to be an independent risk factor for the failure to attain BP and dual BP and low-density lipoprotein cholesterol goals in patients with concomitant hypertension and dyslipidemia. | 24393753 |
| Dyslipidemias, Smoking, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Presence of Diabetes, Hypertension, Smoking, Dyslipidemia, Sedentary life style, and Obesity was looked for in these patients. | 24397066 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Sedentary life style (53.84%) was the most common risk factor present in these patients followed by hypertension and dyslipidemia (47.11% each), smoking (43.27%), diabetes (35.57%), and obesity (9.61%). | 24397066 |
| Dyslipidemias, Erectile dysfunction | Deregulated Nutrient Sensing | Higher HbAlc levels and atherogenic dyslipidaemia were associated with erectile dysfunction. | 24397090 |
| MS gene | Deregulated Nutrient Sensing | SIRT1 is decreased during relapses in patients with multiple sclerosis. | 24397908 |
| MS gene | Deregulated Nutrient Sensing | We investigated the expression of SIRT1 in multiple sclerosis (MS) brains and in peripheral blood mononuclear cells (PBMCs) obtained from patients with relapsing-remitting multiple sclerosis. | 24397908 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Sex, diabetes, dyslipidaemia, hypertension or obesity did not significantly influence Tang in patients, although detected in smokers. | 24399233 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | We show that irisin serum concentrations decrease with increasing CKD stage and are independently and positively predicted by renal function and insulin resistance. | 24399249 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | However, many patients on statin treatment have persistent dyslipidemia and remain at a high risk of cardiovascular disease. | 24400085 |
| Inflammation, Muscle (organ) | Deregulated Nutrient Sensing | Although the causes of muscle loss are poorly understood, dietary fat has been postulated to have a role in determining protein turnover through an influence on both inflammation and insulin resistance. | 24401817 |
| Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Several conditions such as hypertension, diabetes, and obesity can impair shear stress, but the role of insulin resistance has never been investigated. | 24402299 |
| Inflammation, Low muscle mass, Endothelial dysfunction | Deregulated Nutrient Sensing | Increasing physical activity, consuming a diet with a high proportion of energy from carbohydrates, and taking steps to prevent insulin resistance and reduce inflammation and endothelial dysfunction may help to reduce the risk of low muscle mass in older men. | 24402385 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Many studies have shown that single nucleotide polymorphisms (SNPs) in the Adiponectin gene are associated with low plasma Adiponectin levels, insulin resistance and an increased risk of type 2 diabetes mellitus. | 24404592 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Role of adiponectin in mediating the association of osteocalcin with insulin resistance and type 2 diabetes: a cross sectional study in pre- and post-menopausal women. | 24405382 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The protective action of osteocalcin against the development of insulin resistance and type 2 diabetes in women may be partially mediated through up-regulation of adiponectin secretion. | 24405382 |
| Hyperglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemia associated with progressive development of insulin resistance and frank diabetes. | 24405752 |
| Chronic heart failure | Deregulated Nutrient Sensing | Spironolactone, not furosemide, improved insulin resistance in patients with chronic heart failure. | 24405838 |
| Chronic heart failure, Congestive heart failure | Deregulated Nutrient Sensing | Insulin resistance plays an important role in the pathophysiology in chronic heart failure (CHF). | 24405838 |
| Congestive heart failure | Deregulated Nutrient Sensing | Diuretics generally have harmful effects on glucose metabolism, however, the effect of mineral corticoid receptor blockers on insulin resistance in CHF is unclear. | 24405838 |
| Congestive heart failure | Deregulated Nutrient Sensing | Spironolactone, not furosemide, improved insulin resistance in CHF patients probably by the inhibition of inflammatory cytokines and MMPs. | 24405838 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival. | 24410795 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | In the literature there is no evidence for SIRT1 signalling in vitiligo and its possible involvement in disease progression. | 24410795 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | Here, biopsies were taken from the perilesional skin of 16 patients suffering from non-segmental vitiligo and SIRT1 signalling was investigated in these cells. | 24410795 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | For the first time, a new SIRT1/Akt, also known as Protein Kinase B (PKB)/mitogen-activated protein kinase (MAPK) signalling has been revealed in vitiligo. | 24410795 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | SIRT1 regulates MAPK pathway via Akt-apoptosis signal-regulating kinase-1 and down-regulates pro-apoptotic molecules, leading to decreased oxidative stress and apoptotic cell death in perilesional vitiligo keratinocytes. | 24410795 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | We therefore propose SIRT1 activation as a novel way of protecting perilesional vitiligo keratinocytes from damage. | 24410795 |
| Alzheimers Disease", Impaired cognition, Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and type 2 diabetes are associated with cognitive decline and increased risk for Alzheimer's disease (AD). | 24411018 |
| Heart Diseases, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Male stroke patients were more likely to have a history of smoking, heart disease and dyslipidemia, while female patients were less likely to achieve daily living independence. | 24411132 |
| Ischemia, Dyslipidemias | Deregulated Nutrient Sensing | The aim of the study was to define the role of CIDEA gene in patients with dyslipidemia and symptomatic limb ischemia. | 24413203 |
| Liver carcinoma | Deregulated Nutrient Sensing | Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells. | 24416313 |
| Liver carcinoma | Deregulated Nutrient Sensing | We have recently found that SIRT1 expression is highly elevated in hepatocellular carcinoma, and the depletion of SIRT1 leads to substantial reduction in TERT mRNA and protein expression. | 24416313 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | It can be concluded that dyslipidemia and obesity were prevalent amongst this group of women. | 24418877 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Recent research has indicated a relationship between skeletal muscle mass and insulin resistance in patients with type 2 diabetes mellitus (T2DM). | 24420336 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | In this study, we investigated whether AMPK-mediated Cx43 expression and premature senescence in diabetic nephropathy are associated with mTOR activation. | 24423443 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | From in vivo and in vitro studies, we found decreased expression of Cx43 and p-AMPK but increased expression of p21 both in the glomeruli of diabetic nephropathy and in primary GMCs cultured in high glucose. | 24423443 |
| therapeutic hemodilution | Deregulated Nutrient Sensing | CEA may be affected in obese individuals by several factors, including but not limiting to hemodilution, inflammatory conditions, and insulin resistance. | 24425143 |
| Liver carcinoma, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Opposite association between diabetes, dyslipidemia, and hepatocellular carcinoma mortality in the middle-aged and elderly. | 24425422 |
| Dyslipidemias, FAM126A gene | Deregulated Nutrient Sensing | More research is needed to elucidate why having baseline dyslipidemia relates to lower future HCC mortality. | 24425422 |
| Overweight, Obesity | Deregulated Nutrient Sensing | This study of a cohort of overweight and obese subjects has shown that insulin resistance (dependent variable) is positively associated with C3 serum levels, independently of age, gender, anthropometric parameters and physical activity, suggesting that higher C3 serum levels may directly increase insulin resistance in obesity. | 24428680 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Lipid, adipokine and ghrelin levels in myocardial infarction patients with insulin resistance. | 24433403 |
| Electrocardiogram: myocardial infarction (finding), Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Insulin resistance (IR) is a risk factor for ischaemic heart disease and myocardial infarction (MI). | 24433403 |
| Hypoglycemia, Dyslipidemias, Hyperinsulinism | Deregulated Nutrient Sensing | Dyslipidaemia, along with insulinaemia and glycaemia, is one of the most significant IR risk factors in the acute and early recovery phases of MI. | 24433403 |
| Glucose Intolerance (disease), Ulcer | Deregulated Nutrient Sensing | We enrolled 25 obese subjects without glucose intolerance (group A; BMI greater than 30 kg/m2), 20 obese adults intolerant to glucose (group B) and two subgroups, groups C and D, with T2DM and with leg ulcers. | 24434128 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Oatmeal diet days may improve insulin resistance in patients with type 2 diabetes mellitus. | 24434762 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension often coexists with dyslipidemia, accentuating cardiovascular risk. | 24436326 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance participates in the pathogenesis of multiple metabolic and cardiovascular diseases. | 24436478 |
| Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Diabetes Mellitus | Deregulated Nutrient Sensing | This ratio increases when adjusted for sex, hypertension, dyslipidaemia, smoking, diabetes and atrial fibrillation (OR, 2.6; 95% CI, 1.5-4.7). | 24438335 |
| Injury of kidney | Deregulated Nutrient Sensing | Kidney injury molecule (KIM)-1 is associated with insulin resistance: results from two community-based studies of elderly individuals. | 24438875 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance has been shown to be closely associated with glomerular filtration rate and urinary albumin/creatinine ratio, even prior to the development of diabetes. | 24438875 |
| Renal tubule structure | Deregulated Nutrient Sensing | The role of insulin resistance in the development of kidney tubular damage is not previously reported. | 24438875 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients from high-income countries were older, and were more likely to have diagnosed hypertension and dyslipidemia. | 24440324 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Individuals with metabolic risk factors, particularly, insulin resistance, diabetes, and overweight/obesity, have a high prevalence of NAFLD estimated up to 70%, yet little is known about the understanding and perceptions of NAFLD in these high-risk patients. | 24440943 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The protein deacetylase SIRT1 regulates various pathways in metabolism, aging and cancer. | 24441046 |
| Malignant neoplasm of skin | Deregulated Nutrient Sensing | However, the role of SIRT1 in skin cancer remains unclear. | 24441046 |
| Ultraviolet B radiation, Malignant neoplasm of skin | Deregulated Nutrient Sensing | Here, using mice with targeted deletions of SIRT1 in their epidermis in both resistant B6 and sensitive SKH1 hairless backgrounds, we show that the role of SIRT1 in skin cancer development induced by ultraviolet B (UVB) radiation is dependent on its gene dose. | 24441046 |
| Brain Injury, Chronic, Neoplasms | Deregulated Nutrient Sensing | Keratinocyte-specific heterozygous deletion of SIRT1 promotes UVB-induced skin tumorigenesis, whereas homozygous deletion of SIRT1 suppresses skin tumor development but sensitizes the B6 mice to chronic solar injury. | 24441046 |
| Squamous cell carcinoma of skin | Deregulated Nutrient Sensing | As compared with normal human skin, downregulation of SIRT1 is in parallel with downregulation of XPC in human cutaneous squamous cell carcinoma at both the protein and mRNA levels. | 24441046 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Our results reveal the gene dosage-dependent in vivo functions of SIRT1 in skin tumorigenesis and may shed light on the role of SIRT1 in epithelial cancer induced by DNA damage. | 24441046 |
| Steatohepatitis, Dyslipidemias, Dystonia, Dopa-Responsive, due to Sepiapterin Reductase Deficiency | Deregulated Nutrient Sensing | Offspring where SRD was fed at any period of life showed: (1) increased adipose tissue weight without changes in the final body weight; (2) dyslipidemia as a result of increased very low density lipoprotein triglyceride secretion rate and decreased triglyceride clearance; (3) hepatic steatosis associated with increased activity of key enzymes involved in liver de novo lipogenesis and significant decrease of the activity of mitochondrial fatty acid oxidation enzyme. | 24445301 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes. | 24446723 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa. | 24447396 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The peroxisome proliferator-activated receptor gamma (PPARG), Pro12Ala and the insulin receptor substrate (IRS1), Gly972Arg confer opposite effects on insulin resistance and type 2 diabetes mellitus (T2DM). | 24447396 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | A total of 68% of PCOS adolescents had insulin resistance. | 24447981 |
| Dyslipidemias, Diabetes Mellitus, Abnormal renal function, Cerebrovascular Disorders, Hypertension, CTCAE | Deregulated Nutrient Sensing | In the univariate analysis, the major risk factors for kidney dysfunction in the patients with the cardio-cerebrovascular disease were age, gender, hypertension, diabetes mellitus, dyslipidemia and serum uric acid. | 24448380 |
| diabetic | Deregulated Nutrient Sensing | In addition to comparing the neuroimaging profiles of both groups, we correlated neuroimaging findings with HbA1c levels, duration of T2DM, and insulin resistance measurement (HOMA-IR) in the diabetic patients group. | 24448784 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Second-line treatments for dyslipidemia in patients at risk of cardiovascular disease. | 24452015 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The cardiovascular risk factors of ACS were hypertension(HT), diabetes mellitus(DM), smoking, dyslipidemia and obesity(BMI >= 23 kg/m(2)). | 24452116 |
| Dyslipidemias, Haiti | Deregulated Nutrient Sensing | In the elderly group, the prevalence of HT and DM were 84.6% and 29.0% higher than that in the non elderly group; the prevalence of smoking and dyslipidemia were 22.0% and 56.9% lower than that in the non-elderly group. | 24452116 |
| Hypertensive disease, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The prevalence of HTN and DM was higher, smoking and dyslipidemia were lower, being overweight and having a prior myocardial infarction was similar to that of the non-elderly group. | 24452116 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Although significant, the degree of correlation was weakened in the subjects without pancreatic cancer because some had lower insulin secretory reserve compensated by less insulin resistance, resulting in inappropriately elevated G/I ratios relative to A1C. | 24452875 |
| Dyslipidemias, Hyperglycemia, Hypertension, CTCAE, Vascular Diseases | Deregulated Nutrient Sensing | All patients received multifactorial intervention, with pharmacologic therapy targeting hyperglycemia, hypertension, dyslipidemia, along with secondary prevention of vascular disease with aspirin when necessary according to the ADA recommendation. | 24452874 |
| Heart failure, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance and incident heart failure the ARIC study (Atherosclerosis Risk in Communities). | 24455475 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus increases the risk for HF, but the association between insulin resistance and HF in individuals without diabetes is unclear. | 24455475 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The Japan Atherosclerosis Society's 2007 Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases (JAS2007GL) advocate reducing LDL cholesterol (LDL-C) to target levels in patients with dyslipidemia, but achievement rates are frequently unsatisfactory even in the presence of lipid-lowering therapy. | 24456217 |
| Inflammation, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India. | 24456991 |
| Inflammation, Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFa and IL6). | 24456991 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidemia is a significant contributor to the elevated CVD risk observed in type 2 diabetes mellitus. | 24461346 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Effect of a mixed meal on plasma lipids, insulin resistance and systemic inflammation in non-obese Indian adults with normal glucose tolerance and treatment naive type-2 diabetes. | 24461623 |
| Dyslipidemias | Deregulated Nutrient Sensing | High post meal glucose levels have been linked to postprandial dyslipidemia and generation of proinflammatory cytokines. | 24461623 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Group medical clinics may improve diabetes and hypertension control, but data about dyslipidemia are limited. | 24462012 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In 2011, the majority belonged to stages 3A (39.6%) and 3B (37.6%), had hypertension (98.2%), dyslipidemia (97.2%) and diabetes mellitus (68.7%). | 24463824 |
| Data types - Address | Deregulated Nutrient Sensing | Our study revealed that (1) the neuronal subcellular redistribution of SIRT1 parallels the decrease in its expression, suggesting stepwise loss of neuroprotection dependent on the neuronal population; (2) in contrast to SIRT1 and 3, expression of SIRT5 increases during the progression of AD; (3) which might be related to its appearance in activated microglial cells. | 24464653 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In simple regression analysis, free testosterone levels were associated with increased age (b = -0.04; P = .02), diet (b = -0.49; P = .05), diabetes (b = -0.9; P = .003), and hypertension (b = -0.55; P = .03) but not with race/ethnicity, smoking, exercise, obesity, or dyslipidemia. | 24468578 |
| Increased insulin level, Diabetes Mellitus | Deregulated Nutrient Sensing | The proband's mother had hyperinsulinemia and diabetes mellitus but did not show any common clinical features of type A insulin resistance. | 24468607 |
| Increased insulin level, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The proband's brother also had hyperinsulinemia but manifested neither glucose intolerance nor common clinical features of type A insulin resistance. | 24468607 |
| Refractory anemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We examined the effect of HCQ on insulin resistance in subjects without diabetes mellitus with stable RA. | 24470436 |
| Refractory anemias, Diabetes Mellitus | Deregulated Nutrient Sensing | HCQ use for 8 weeks in patients without diabetes mellitus with stable RA produced no significant change in insulin resistance. | 24470436 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | However, risk factors such as age, BMI, hypertension, dyslipidemia, diabetes mellitus and smoking have a strong impact on stroke occurrence and outweigh the protective role of the e3/e3 genotype. | 24471738 |
| Dyslipidemias, Osage language | Deregulated Nutrient Sensing | Despite similar body mass index (BMI) and waist circumference, men had larger VFA, more severe OSA, and more severe dyslipidemia than women. | 24471804 |
| Inflammation, physiopathological | Deregulated Nutrient Sensing | Adipose dysfunction resulting from chronic inflammation and impaired adipogenesis has increasingly been recognized as a major contributor to obesity-mediated insulin resistance, but the molecular mechanisms that maintain healthy adipocytes and limit adipose inflammation remain unclear. | 24473437 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | These data suggest that the SK1-S1P axis could be an attractive target for the development of treatments to ameliorate adipose inflammation and insulin resistance associated with obesity and type 2 diabetes. | 24473437 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance (IR) in skeletal muscle is a prerequisite for type 2 diabetes and is often associated with obesity. | 24473441 |
| Dyslipidemias, Smoking, Coronary heart disease | Deregulated Nutrient Sensing | Smoking, dyslipidemia, family history, and lipoprotein(a) and lymphotoxin-alfa mutations in men were independent variables associated with coronary disease. | 24473507 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | SIRT1/macroH2A1.1-dependent epigenetic regulation of lipid metabolism may be relevant to NAFLD development. | 24473773 |
| Acquired Immunodeficiency Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | The effects of a diet formulation with oats, soybeans, and flax on lipid profiles and uricemia in patients with AIDS and dyslipidemia. | 24474009 |
| Lipodystrophy, Hyperglycemia, Metabolic Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Although the initiation of highly active antiretroviral therapy (HAART) is accompanied by an attenuation of viral load, metabolic disorders characterized by hyperglycemia, dyslipidemia, and lipodystrophy are often observed in patients under this treatment. | 24474009 |
| Dyslipidemias, Psoriasis, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus. | 24474099 |
| Dyslipidemias, Psoriasis, Obesity | Deregulated Nutrient Sensing | To evaluate the occurrence of obesity and dyslipidemia in patients with psoriasis treated at a dermatology clinic in Manaus. | 24474099 |
| Dyslipidemias, Psoriasis, Obesity | Deregulated Nutrient Sensing | We performed a prospective descriptive study to assess the prevalence of obesity and dyslipidemia in patients with psoriasis. | 24474099 |
| Dyslipidemias | Deregulated Nutrient Sensing | Regarding the diagnosis of dyslipidemia, 29 (65.9%) females and 22 (78.6%) males showed alterations in lipid profile. | 24474099 |
| Metabolic Diseases, Dyslipidemias, Psoriasis, Obesity | Deregulated Nutrient Sensing | The occurrence of dyslipidemia and obesity in patients with psoriasis can affect life quality and expectancy, increasing the risk of systemic and metabolic diseases, which makes periodic investigation of these comorbidities in patients with psoriasis mandatory. | 24474099 |
| Cancer-related fatigue, Dyslipidemias | Deregulated Nutrient Sensing | High cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations. | 24474445 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Regardless of CKD strata, all ISIs allowed satisfactory clinical discrimination between the presence and absence of insulin resistance (glucose disposal rate under 4 mg/kg/min). | 24476695 |
| Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity | Deregulated Nutrient Sensing | Our results lead to the hypothesis that changes in biomarker levels of insulin resistance, inflammation and CVD risk before puberty might induce metabolic consequences of obesity in obese children before reaching adulthood. | 24476930 |
| Chronic disease | Deregulated Nutrient Sensing | Insulin resistance is a significant cross-point for the manifestation of several chronic diseases in children and adults. | 24477051 |
| Complication Aspects, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | New-onset diabetes after transplantation (NODAT) and dyslipidemia are important metabolic complications after liver transplantation (LT) that can adversely affect both allograft and patient survival. | 24477986 |
| Dyslipidemias, Cardiovascular Diseases, Kidney Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects were older and had higher rates of family history of cardiovascular disease in Australia, while Asian subjects had higher rates of diabetes, dyslipidemia and renal failure. | 24480180 |
| Demographics Domain, Hypertriglyceridemia, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Over half patients (87, 55%) had arterial hypertension (AH); 51 (32%) had dyslipidaemia (DLP), 38 (29%) hypertriglyceridemia and 36 (23%) diabetes mellitus (DM). | 24480317 |
| Pre-Gestational Diabetes, Pre-Eclampsia | Deregulated Nutrient Sensing | Assessment of pregestational insulin resistance as a risk factor of preeclampsia. | 24480896 |
| Pre-Gestational Diabetes, Pre-Eclampsia | Deregulated Nutrient Sensing | To assess the impact that pregestational insulin resistance (PIR) has as a risk factor for preeclampsia (PE). | 24480896 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Our previous research showed that sirtuin 1 (SIRT1) was overexpressed in pancreatic cancer patients and deregulation of SIRT1 with RNAi could enhance chemosensitivity. | 24484175 |
| Palmar-plantar erythrodysesthesia syndrome, Pancreatic carcinoma | Deregulated Nutrient Sensing | Thus, we hypothesized that SIRT1 might facilitate chemoresistance in pancreatic cancer cells through regulating the adaptive response to chemotherapy-induced stress. | 24484175 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | To further confirm the role of SIRT1 in clinical chemotherapy, SIRT1 was detected in eight pancreatic cancer tissues acquired by endoscopy ultrasonography guided fine needle aspiration biopsy before and after chemotherapy. | 24484175 |
| Palmar-plantar erythrodysesthesia syndrome | Deregulated Nutrient Sensing | Thus, our results indicated a special role for SIRT1 in the regulation of adaptive response to chemotherapy-induced stress, which is involved in chemoresistance. | 24484175 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Moreover, it indicates that blocking SIRT1 activity with targeting drugs might be a novel strategy to reverse the chemoresistance of pancreatic cancer. | 24484175 |
| Palmar-plantar erythrodysesthesia syndrome, Pancreatic carcinoma | Deregulated Nutrient Sensing | Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress. | 24484175 |
| Hypertension, CTCAE, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | Patients with HFpEF (n = 499) were older, overweight, predominantly women, and had underlying hypertension and dyslipidemia. | 24484862 |
| Fatty Liver | Deregulated Nutrient Sensing | Among polymorphisms, C677T, a thermolabile form, but not A1298C, thermostable, was associated with fatty liver and insulin resistance. | 24488901 |
| Diabetes Mellitus, Ketosis-Prone, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The KPD patients were more likely to have a strong family history of diabetes and a better beta-cell function reserve, and be accompanied with dyslipidemia (52.7%), hypertension (23.3%), fatty liver (10.1%) and hyperuricemia/gout (8. | 24490509 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Modifiable cardiovascular risk factors were dominated by dyslipidemia, diabetes and obesity/overweight. | 24492012 |
| Arterial Stiffness, Diabetes Mellitus | Deregulated Nutrient Sensing | The elevated plasma glucose level and/or insulin resistance in diabetes or impaired glucose tolerance play important roles in the pathogenesis of arterial stiffness. | 24492686 |
| Dyslipidemias, Cerebral Hemorrhage | Deregulated Nutrient Sensing | Dyslipidemia as a risk factor for primary intracerebral hemorrhage. | 24496338 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | The insulin resistance and vitamin D deficiency significantly predicted the obesity risk in PCOS women. | 24496360 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | TNF-a polymorphisms were shown to be associated with insulin resistance and diabetes development and complications. | 24497209 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Moderate changes in obesity measures tracked with a significant deterioration in measures of pro-atherogenic dyslipidaemia at both personal and population level. | 24497983 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Renal function, Diabetes Mellitus | Deregulated Nutrient Sensing | Age, diabetes, dyslipidaemia and history of myocardial infarction were identified as significant predictors for renal function deterioration based on results from multivariate Cox regression model. | 24499317 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. | 24502610 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Household income and LDL-C goal attainment in patients with diabetes and dyslipidemia in a Canadian dataset. | 24502811 |
| Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity and insulin resistance are risk factors for cardiovascular diseases. | 24502884 |
| SLC25A20 gene, Dyslipidemias, Comorbidity, Cardiovascular Diseases | Deregulated Nutrient Sensing | In univariate Cox regression analyses, age, cardiovascular disease, dyslipidemia, increased CAC score, increased comorbidity score and decreased hip BMD were associated with mortality. | 24503711 |
| Acute leukemia | Deregulated Nutrient Sensing | We first analyzed the expression of miR-34a, CDK4, MYB and SIRT1 in peripheral blood samples from acute leukemia (AL) patients and healthy controls, and conducted a correlation analysis. | 24504520 |
| Acute leukemia | Deregulated Nutrient Sensing | miRNA-34a downregulates the expression of the CDK4, MYB and SIRT1 genes in vitro; it may thus represent a novel therapeutic target for acute leukemia. | 24504520 |
| ADIPOQ protein, human | Deregulated Nutrient Sensing | [Association of resistin gene 3'UTR+62G>A polymorphism with insulin resistance, adiposity and the adiponectin-resistin index in Mexican population]. | 24506362 |
| Hyperparathyroidism, Hyperparathyroidism, Primary, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Primary hyperparathyroidism and secondary hyperparathyroidism are both associated with abnormalities in glucose metabolism, such as insufficient insulin release and glucose intolerance. | 24507041 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | [Association between dyslipidemia and different subtypes of hypertension among Zhejiang population in 2010]. | 24507231 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | To explore the association between dyslipidemia and different subtypes of hypertension among Zhejiang population. | 24507231 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia is an important factor of different subtypes of hypertension among Zhejiang population, especially triglycerides. | 24507231 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia screening should be strengthened to reduce the risk of cardiovascular diseases. | 24507231 |
| Dyslipidemias, Primary Biliary Cholangitis, Deterioration | Deregulated Nutrient Sensing | Because the majority of PBC patients exhibit a slow progression of their disease, and since the administration of UDCA plus fibrate may further delay the liver deterioration, cardiovascular risk factors, such as dyslipidemia may thus have a bigger impact on the long-term survival of PBC patients. | 24511666 |
| Obesity | Deregulated Nutrient Sensing | Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance. | 24512489 |
| Obesity | Deregulated Nutrient Sensing | Our objective was to define the function of GIP in human adipose tissue in relation to obesity and insulin resistance. | 24512489 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Nonalcoholic Fatty liver disease is associated with increased carotid intima-media thickness only in type 2 diabetic subjects with insulin resistance. | 24512497 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, atherosclerotic | Deregulated Nutrient Sensing | The objective of the study was to investigate the participation of insulin resistance in the association of NAFLD and the carotid atherosclerotic burden in a large cohort of patients with type 2 diabetes. | 24512497 |
| Non-alcoholic Fatty Liver Disease, Atherosclerosis | Deregulated Nutrient Sensing | There were significant differences in C-IMT and the frequency of carotid atherosclerosis between groups classified by insulin resistance within the same NAFLD strata. | 24512497 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | C-IMT was highest in subjects with both NAFLD and insulin resistance [0.844 +- 0.004 (mean +- SE) mm vs 0.786 +- 0.008, 0.821 +- 0.007, and 0.807 +- 0.006 mm, P for trend <.001, respectively, in insulin sensitive subjects without NAFLD, insulin resistant subjects without NAFLD, and insulin sensitive subjects with NAFLD]. | 24512497 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | However, C-IMT in subjects having only NAFLD or insulin resistance was not higher than that in those with neither NAFLD nor insulin resistance. | 24512497 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, atherosclerotic | Deregulated Nutrient Sensing | NAFLD is very common in subjects with type 2 diabetes, but NAFLD not accompanied by insulin resistance is not associated with a carotid atherosclerotic burden. | 24512497 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | However, having both NAFLD and insulin resistance seemed to be an independent predictor of increased C-IMT. | 24512497 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is linked to increased risk of insulin resistance and diabetes mellitus in patients' later life. | 24515540 |
| Inflammation, Impaired | Deregulated Nutrient Sensing | TNFa is suspected to play a role in inflammation and insulin resistance leading to higher risk of metabolic impairment. | 24517151 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The control rate was significantly lower among patients with longer course of diabetes and dyslipidemia. | 24517934 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | In approximately 50-70% of all women with PCOS (Polycystic Ovarian Syndrome) may be found lower or higher degree insulin resistance, while insensitivity to insulin cells very likely contributes hyperandrogenaemia which is responsible for the symptoms and signs of PCOS. | 24520755 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | The emergence of prediabetes is significantly correlated with insulin resistance as confirms the impact of the insulin resistance degree to the emergence of prediabetes. | 24520755 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for premature cardiovascular morbidity and mortality in renal transplant recipients (RTRs). | 24521776 |
| Ventricular Dysfunction | Deregulated Nutrient Sensing | Early subclinical ventricular dysfunction in patients with insulin resistance. | 24522082 |
| Ventricular Dysfunction, Left | Deregulated Nutrient Sensing | Insulin resistance is frequently associated with subclinical left-ventricular dysfunction. | 24522082 |
| Shock | Deregulated Nutrient Sensing | Heat shock protein inducers share metabolic pathways associated with exercise with activation of AMPK, PGC1-a, and sirtuins. | 24523032 |
| Presenile dementia, Impaired cognition | Deregulated Nutrient Sensing | In addition to insulin resistance, elevated inflammatory cytokines and oxidative stress were associated with cognitive impairment in this type of dementia. | 24523311 |
| Hepatitis C | Deregulated Nutrient Sensing | Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients. | 24523350 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In a multiple logistic regression model, male sex, diabetes, and prior CAD predicted adverse events, whereas CK-MB along with race, hypertension, smoking, dyslipidemia, family history, and obesity did not. | 24526146 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary Artery Disease, Cerebrovascular accident | Deregulated Nutrient Sensing | No significant differences in the rates of dyslipidaemia, previous myocardial infarction, previous stroke, and coronary artery disease were seen between the groups. | 24526553 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Fatty Liver Disease | Deregulated Nutrient Sensing | Non alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance (IR) and increased type 2 diabetes (T2D). | 24528352 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our study demonstrated that ALT, but not AST, was significantly correlated with of insulin resistance and inflammatory markers, all of them recognized as risk parameters of pre diabetes stage. | 24528352 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance (IR) plays a role in the development and progression of atherosclerosis. | 24529152 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia, especially an increased LDL-cholesterol, has been shown to be one of the most important risk factors in the genesis of coronary involvement. | 24529919 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Increased insulin concentration is a surrogate for insulin resistance and early assessment of fasting insulin may help in identifying those who are potentially at high risk of type 2 diabetes, hypertension, and cardiovascular disease. | 24530467 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for not only cardiovascular diseases (CVD), but also chronic kidney disease (CKD). | 24531086 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | However, very few studies have examined its efficacy and safety for patients with dyslipidemia complicated with CKD. | 24531086 |
| Cardiovascular Diseases, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Cerebrovascular accident, Coronary Artery Disease, Obesity, Cessation of life, Hypertension, CTCAE | Deregulated Nutrient Sensing | Cardiovascular disease (CVD) risk factors, such as arterial hypertension, obesity, dyslipidemia or diabetes mellitus, as well as CVDs, including myocardial infarction, coronary artery disease or stroke, are the most prevalent diseases and account for the major causes of death worldwide. | 24532105 |
| Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | The study sample was 1,016 participants in the insulin resistance atherosclerosis study, who had no previous diagnosis of diabetes. | 24532116 |
| Heat-Shock Response | Deregulated Nutrient Sensing | Muscle heat shock protein 70 predicts insulin resistance with aging. | 24532784 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Retinol-binding protein 4 in rheumatoid arthritis-related insulin resistance and b-cell function. | 24532832 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Retinol-binding protein 4 (RBP4), an adipokine related to impaired glucose tolerance, has been associated with insulin resistance (IR) and b-cell function in subjects with obesity or diabetes. | 24532832 |
| Thrombophilia, Atherosclerosis, Dyslipidemias, Hypothyroidism, Saint Helena Islands | Deregulated Nutrient Sensing | Subclinical hypothyroidism (SH) is associated with increased risk for atherosclerosis, mainly attributable to dyslipidaemia and hypercoagulability. | 24548294 |
| Dyslipidemias, Lower Urinary Tract Symptoms, Angina Pectoris, Diabetes Mellitus | Deregulated Nutrient Sensing | Predictors of ED remission were lower age, current employment, and absence of voiding LUTS, angina, diabetes, and dyslipidemia. | 24548342 |
| Cancer-related fatigue | Deregulated Nutrient Sensing | In conclusion, among abdominally obese women, WC and CRF are independently associated with measures of glucose tolerance and insulin resistance and mediate the association between MVPA and insulin resistance. | 24552378 |
| Primary malignant neoplasm, Breast Carcinoma | Deregulated Nutrient Sensing | We recently established a pre-clinical model of estrogen-dependent MCF-7 breast cancer cells that were chronically adapted to grow (> 10 months) in the presence of graded, millimolar concentrations of the anti-diabetic biguanide metformin, an AMPK agonist/mTOR inhibitor that has been evaluated in multiple in vitro and in vivo cancer studies and is now being tested in clinical trials. | 24553122 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Using a cross-sectional survey of adults living in a middle-income neighborhood of Dhaka, Bangladesh, we tested the hypothesis that the prevalence of CKD in this group would approach that of the U.S. and would be strongly associated with insulin resistance. | 24555767 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | A participant with insulin resistance had a 3.6-fold increase in odds of CKD (95% confidence interval 2.1 to 6.4). | 24555767 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | We found an alarmingly high prevalence of CKD--particularly CKD associated with insulin resistance-in middle-income, urban Bangladeshis. | 24555767 |
| Dyslipidemias, Depression, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | This study provides insight into the potential risk factors for diabetes such as the presence of obesity, dyslipidemia, and depression, specifically in patients with HbA1c levels above 9%. | 24556384 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | No correlations were found between the CCT and dyslipidemia, diabetes, or hypertension. | 24556853 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | No associations were found between the CCT and dyslipidemia, diabetes, or hypertension. | 24556853 |
| Inflammation, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, physiopathological | Deregulated Nutrient Sensing | Inflammation, insulin resistance and vascular dysfunction characterize obesity and predict development of cardiovascular disease (CVD). | 24559846 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1years. | 24560422 |
| Deficit | Deregulated Nutrient Sensing | We further set out to determine if pharmacological activation of 5'-AMP-activated protein kinase (AMPK) might counteract any of these functional deficits. | 24561866 |
| Peripheral Vascular Insufficiency | Deregulated Nutrient Sensing | Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice. | 24561866 |
| Muscle fatigability | Deregulated Nutrient Sensing | Treatment of animals with an AMPK activator, R118, increased voluntary wheel running activity, decreased muscle fatigability, and prevented the progressive decrease in treadmill exercise capacity. | 24561866 |
| Intermittent Claudication, Peripheral Vascular Insufficiency, Impaired exercise tolerance | Deregulated Nutrient Sensing | These data suggest that aged, obese mice represent a novel model for studying exercise intolerance associated with peripheral vascular insufficiency, and pharmacological activation of AMPK may be a suitable treatment for intermittent claudication associated with PAD. | 24561866 |
| Data types - Address | Deregulated Nutrient Sensing | Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. | 24567379 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)]. | 24567379 |
| Cognition Disorders | Deregulated Nutrient Sensing | Older MG(+)-fed mice, similar to old Reg controls, developed MS, increased brain amyloid-b42, deposits of AGEs, gliosis, and cognitive deficits, accompanied by suppressed SIRT1, nicotinamide phosphoribosyltransferase, AGE receptor 1, and PPARg. | 24567379 |
| Inflammation, Data types - Address | Deregulated Nutrient Sensing | The data identify a specific AGE (MG) as a modifiable risk factor for AD and MS, possibly acting via suppressed SIRT1 and other host defenses, to promote chronic oxidant stress and inflammation. | 24567379 |
| Data types - Address | Deregulated Nutrient Sensing | Because SIRT1 deficiency in humans is both preventable and reversible by AGE reduction, a therapeutic strategy that includes AGE reduction may offer a new strategy to combat the epidemics of AD and MS. | 24567379 |
| Dyslipidemias | Deregulated Nutrient Sensing | Although lifestyle and diet are considered to have a role in global BC incidence pattern, the specific influence of dyslipidemia in BC onset and progression is not yet completely understood. | 24571647 |
| Dyslipidemias, atherosclerotic, Cardiovascular Diseases | Deregulated Nutrient Sensing | Atherosclerotic changes associated with dyslipidemia and increased cardiovascular disease risk are believed to begin in childhood. | 24572253 |
| Dyslipidemias | Deregulated Nutrient Sensing | There was a declining trend in the prevalence of dyslipidemia and an increasing trend in the rates of use of lipid-lowering medication among Korean adults. | 24573366 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Risk factors for PU were hypertension, dyslipidemia, and chronic kidney disease. | 24574832 |
| Presenile dementia, Impaired cognition, diabetic | Deregulated Nutrient Sensing | Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. | 24577463 |
| Presenile dementia, Hyperglycemia, Impaired cognition | Deregulated Nutrient Sensing | Further studies should establish the role of hyperglycemia and insulin resistance, and the protective role of metformin in the risk of cognitive decline and dementia. | 24577463 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The positive trends of age-adjusted rates of hypertension and dyslipidemia were significantly steeper in females than in males. | 24579915 |
| Hypertension, CTCAE, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Smoking and heavy alcohol consumption were significantly associated with CVD, and increased BMI was significantly associated with hypertension and dyslipidemia among subjects with type 2 diabetes in this study population. | 24581089 |
| Hyperglycemia | Deregulated Nutrient Sensing | In elective surgery, postoperative hyperglycaemia and insulin resistance are independent risk factors for complications. | 24581942 |
| Dyslipidemias, Sleep Apnea, CTCAE, Hypertension, CTCAE | Deregulated Nutrient Sensing | On average, each patient had 4 co-morbidities preoperatively, with hypertension (n = 49; 86%), dyslipidemia (n = 40; 70%), and sleep apnea (n = 31; 54%) being the most common. | 24582414 |
| Dyslipidemias, Diabetes Mellitus, Sleep Apnea, CTCAE, Back Pain, Hypertension, CTCAE | Deregulated Nutrient Sensing | The resolution of hypertension, dyslipidemia, sleep apnea, lower back pain, and non-insulin-dependent diabetes was 27%, 28%, 35%, 31%, and 35%, respectively. | 24582414 |
| Non-alcoholic Fatty Liver Disease, Inflammation, Obesity, Abdominal, Fatty degeneration | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD), characterized by accumulation of hepatic triglycerides (steatosis), is associated with abdominal obesity, insulin resistance, and inflammation. | 24582567 |
| Fatty degeneration | Deregulated Nutrient Sensing | Resveratrol is a polyphenol that prevents high-energy diet-induced steatosis and insulin resistance in animals by up-regulating pathways that regulate energy metabolism. | 24582567 |
| Fatty degeneration | Deregulated Nutrient Sensing | Eight-week administration of resveratrol did not reduce insulin resistance, steatosis, or abdominal fat distribution when compared with baseline. | 24582567 |
| Dyslipidemias, Diabetes Mellitus, Cavia, Hypertension, CTCAE, atherosclerotic | Deregulated Nutrient Sensing | 2) Among the control subjects, the CAVI values in the subjects with atherosclerotic risk factors (hypertension, dyslipidemia and/or diabetes) were significantly higher than those observed in the subjects without risk factors. | 24583429 |
| Neoplasms | Deregulated Nutrient Sensing | A reduction in PI3K and mTORC1/mTORC2 pathway signaling was observed in serial hair sheath cells, skin, and tumor samples. | 24583798 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | Multivariable regression analysis revealed that DM, dyslipidemia, elevated sVEGFR-1, and reduced VEGF and PLGF in serum were independently associated with a low degree of coronary collateralization. | 24583918 |
| Hyperglycemia | Deregulated Nutrient Sensing | All severely burned patients exhibited burn-induced insulin resistance and hyperglycemia. | 24584061 |
| Inflammation, Cardiovascular Diseases, Dyslipidemias, Depressed mood, Disease | Deregulated Nutrient Sensing | We conclude that this study contributes the first evidence of a correlation between marked dyslipidemia and worsened Cu/Zn ratios in HPs, implying an increased risk of diseases associated with elevated oxidative stress, inflammation, and depressed immune function, such as cardiovascular diseases. | 24585396 |
| Deficiency of butyryl-CoA dehydrogenase, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia (SCAD: 30.8% vs. PR: 63.8% vs. non-SCAD/non-PR: 67.5%, p=0.03) and current smoking (SCAD: 7.7% vs. PR: 57.9% vs. non-SCAD/non-PR: 59.7%, p<0.01) were significantly lower in the SCAD group. | 24585938 |
| Inflammation, Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Comparison of efficacy of intensive versus mild pitavastatin therapy on lipid and inflammation biomarkers in hypertensive patients with dyslipidemia. | 24586502 |
| Inflammation, Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | This study assigned essential hypertensive patients with dyslipidemia to 6 months administration of mild (1 mg/day, n = 34) or intensive pitavastatin therapy (4 mg/day, n = 29), and various lipid and inflammation biomarkers were measured at baseline, and 3 and 6 months after the start of treatment. | 24586502 |
| Obesity | Deregulated Nutrient Sensing | Lower levels have been observed in obesity, insulin resistance, and in critical illness. | 24586568 |
| Inflammation, Dyslipidemias, HIV Infections, Atherosclerosis | Deregulated Nutrient Sensing | The increased immune activation and inflammation of chronic HIV-infection and the characteristic dyslipidemias associated with HIV infection and antiretroviral therapy (ART) contribute to an increased risk of atherosclerotic vascular disease among HIV-infected adults. | 24586854 |
| TG gene, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia is a common feature in patients with PM that is characterized by a decrease in HDL-C and an increase in TG, suggesting a high risk of atherosclerosis. | 24587064 |
| Immune dysregulation | Deregulated Nutrient Sensing | Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV. | 24587328 |
| Metabolic Syndrome X, HIV Infections | Deregulated Nutrient Sensing | MO, and specifically classical MO, may contribute to insulin resistance and metabolic syndrome during chronic HIV infection. | 24587328 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases. | 24587358 |
| Pentalogy of Cantrell | Deregulated Nutrient Sensing | This is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSI. | 24587358 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The TyG index, a simple measure reflecting insulin resistance, might be useful in identifying individuals at high risk of developing diabetes. | 24587359 |
| Triglycerides, Carotid Artery Plaque, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity, high triglycerides, and dyslipidemia were not associated with carotid artery plaque or cIMT. | 24588080 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Compared with non-ED group, WME-NS group had higher prevalence of early ED risk factors including endothelial dysfunction, insulin resistance, high level of glycosylated serum protein and abnormal NPTR. | 24589222 |
| Cardiovascular Diseases, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia is one of the primary causes for cardio vascular disease (CVD) and development of myocardial infarction (MI) which often leads to coronary artery disease (CAD). | 24592787 |
| Inflammation, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Although data suggest that the ratio of leptin/adiponectin correlates with insulin resistance and predicts cardiovascular disease (CVD), there is scanty data on the relationship between the retinol-binding protein-4 (RBP4)/adiponectin ratio with insulin resistance and inflammation. | 24593134 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | It has been attributed, among other causes, to hypertension and dyslipidemia. | 24593225 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To analyse the efficacy of low-dose rosuvastatin for treating hypo high-density lipoprotein (HDL) cholesterolaemia in patients with type 2 diabetes and dyslipidaemia. | 24595147 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Do insulin resistance conditions further impair the lipid and inflammatory profile in end-stage renal disease patients on hemodialysis? | 24601848 |
| HD Term Type | Deregulated Nutrient Sensing | Neither was the proinflammatory profile further altered in HD patients in the presence of insulin resistance conditions. | 24601848 |
| Overweight | Deregulated Nutrient Sensing | Among overweight children, an increase of 10 ng perfluorooctane sulfonic acid/mL plasma was associated with 16.2% (95% confidence interval [CI], 5.2%-28.3%) higher insulin concentration, 12.0% (95% CI, 2.4%-22.4%) higher b-cell activity, 17.6% (95% CI, 5.8%-30.8%) higher insulin resistance, and 8.6% (95% CI, 1.2%-16.5%) higher triglyceride concentrations, and an increase of 10 ng perfluorooctanoic acid/mL plasma was associated with 71.6% (95% CI, 2.4%-187.5%) higher insulin concentration, 67.5% (95% CI, 5.5%-166.0%) higher b-cell function, 73.9% (95% CI, 0.2%-202.0%) higher insulin resistance, and 76.2% (95% CI, 22.8%-153.0%) higher triglyceride concentrations. | 24606078 |
| Units Of Measure - Siemens, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese (MHO) appears relatively protected from the development of cardiometabolic complications. | 24606089 |
| Proteinuria | Deregulated Nutrient Sensing | Inhibition of AGE formation in db/db mice by pyridoxamine treatment attenuated proteinuria and podocyte injury, restored SIRT1 expression, and reduced p65 and STAT3 acetylation. | 24608443 |
| Proteinuria, Injury of kidney, diabetic | Deregulated Nutrient Sensing | Diabetic db/db mice with conditional deletion of SIRT1 in podocytes developed more proteinuria, kidney injury, and acetylation of p65 and STAT3 compared with db/db mice without SIRT1 deletion. | 24608443 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance, especially when are associated with elevate values of ALT level, are strong independent risk factors in developing NAFLD/NASH. | 24608579 |
| Obesity | Deregulated Nutrient Sensing | Fibroblast growth factor (FGF)-21 has recently been introduced as a circulating adipokine which reverses insulin resistance and obesity in rodents. | 24612017 |
| Dyslipidemias, Data types - Address, diabetic | Deregulated Nutrient Sensing | The Discriminant Ratio (DR) methodology was used in 120 type 2 diabetic patients in order: (i) to compute TRL-C from non-fasting lipids; (ii) to establish the performance of TRL-C and TRL-C/apoA-I (vs. TG-based markers) to grade TRLs and atherogenic dyslipidemia (AD); and (iii) to relate TRL-C with non-fasting TG. | 24612479 |
| Fatty Liver | Deregulated Nutrient Sensing | An increase in insulin resistance predicted a 2-fold increased prevalence of fatty liver in all ethnicities after multivariable adjustment. | 24613289 |
| Dyslipidemias, Sarcopenia | Deregulated Nutrient Sensing | Sarcopenia and sarcopenic obesity and their association with dyslipidemia in Korean elderly men: the 2008-2010 Korea National Health and Nutrition Examination Survey. | 24615361 |
| Dyslipidemias, Sarcopenia, Obesity | Deregulated Nutrient Sensing | However, it remains unclear whether SO has greater adverse effects on dyslipidemia than on sarcopenia or obesity alone. | 24615361 |
| Dyslipidemias, Sarcopenia, Obesity | Deregulated Nutrient Sensing | In Korean elderly men, SO was associated with an increased risk for dyslipidemia compared with sarcopenia or obesity alone. | 24615361 |
| Dyslipidemias, atherosclerotic, Atherosclerosis | Deregulated Nutrient Sensing | After the publication of the new guidelines of the European Society of Cardiology and the European Atherosclerosis Society for the prevention and treatment of dyslipidemias (Eur Heart J 32:1769-1818, 2011; Eur Heart J 33:1635-1701, 2012), a group of authors has recently published on behalf of the American Heart Association and the American College of Cardiology guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk (Circulation 2013). | 24615676 |
| Gestational Diabetes, Glucose Intolerance (disease), Fatty degeneration | Deregulated Nutrient Sensing | Hepatic rather than cardiac steatosis relates to glucose intolerance in women with prior gestational diabetes. | 24621572 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Dyslipidemia and outcome in patients with acute ischemic stroke. | 24625400 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. | 24625400 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively. | 24625400 |
| Dyslipidemias, Inappropriate behavior | Deregulated Nutrient Sensing | The diagnosis of dyslipidemia requires >=2 high lipid values, but inappropriate behavior in the diagnosis of dyslipidemia has only previously been analyzed using just total cholesterol (TC). | 24626597 |
| CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | To determine clinical inertia in the dyslipidemia diagnosis using both TC and high-density lipoprotein cholesterol (HDL-c) and its associated factors. | 24626597 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine, has been associated with incident diabetes mellitus and insulin resistance. | 24627569 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Patients with NAFLD showed more insulin resistance than healthy controls. | 24631112 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | However, physical activity was lower in NAFLD compared with healthy controls and was associated with higher body mass index and insulin resistance. | 24631112 |
| vascular inflammations, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance worsen markers of systemic and vascular inflammation. | 24635342 |
| Dyslipidemias, Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | In addition to dyslipidemia, immune activation, HIV-replication and an accumulation of risk factors for atherosclerosis, this adverse antibody profile may be of major importance for the increased risk of cardiovascular disease in HIV + individuals. | 24636004 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and associated risk factors in Turkish adults. | 24636181 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia is a modifiable major risk factor for coronary heart disease. | 24636181 |
| Dyslipidemias | Deregulated Nutrient Sensing | Enhanced public health preventive measures should be implemented to better diagnose and comprehensively treat dyslipidemia in Turkey. | 24636181 |
| AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A was decreased by approximately 8% (pre, 1.01 +- 0.08, vs post, 0.89 +- 0.06 g * L(-1); P < 0.05) after the intervention, and lower fetuin-A after exercise correlated with lower hepatic insulin resistance (r = -0.46, P < 0.01), increased metabolic flexibility (r = -0.70, P < 0.01) and high-molecular weight adiponectin (r = -0.57, P < 0.01). | 24637346 |
| Inflammation, AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A may contribute to exercise training-induced improvements in hepatic insulin resistance, CHO utilization, and inflammation in older obese adults. | 24637346 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | The dependence of the formation of dyslipidemia and related changes of atherosclerosis in the young age on neuroendocrine effects, accompanying the effects of combat stress and promoting accelerated aging was determined. | 24640705 |
| No metabolic abnormalities, Cardiovascular Diseases | Deregulated Nutrient Sensing | Visceral adiposity is linked to the development of insulin resistance, which is a condition that may contribute to metabolic abnormalities and cardiovascular disease. | 24643468 |
| Obesity, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | With regard to cardiovascular risk factors, 70.5% of subjects had dyslipidemia, 26.7% hypertension, 24.8% obesity, 8.4% diabetes and 25.5% were smokers. | 24646328 |
| Dyslipidemias, Antihypertensive Agents | Deregulated Nutrient Sensing | Clinical characteristics of 26 patients were: age 50+-14 (mean+-1SD) years, eGFR 41+-11 ml/min/1.73 m2, males 73%, dyslipidaemia 36%, smokers 23% and hypertensives 87%. | 24646518 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Impaired adipogenesis and insulin resistance in epicardial fat-mesenchymal cells from patients with cardiovascular disease. | 24648294 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | The thickness of epicardial adipose tissue (EAT), which is an inflammatory source for coronary artery disease (CAD), correlates with insulin resistance. | 24648294 |
| physiopathological, Cardiovascular Diseases | Deregulated Nutrient Sensing | Low adipogenesis ability and insulin resistance in EAT-MCs might shed light on the association between EAT dysfunction and cardiovascular disease. | 24648294 |
| Dyslipidemias, TOAST Classification | Deregulated Nutrient Sensing | Overall, dyslipidemia appears as the leading factor, while TOAST classification does not reach statistical significance. | 24650199 |
| Dyslipidemias, atherosclerotic, Cerebrovascular accident | Deregulated Nutrient Sensing | The presence of dyslipidemia remains the main factor influencing statin prescription, while the presence of well-defined atherosclerotic etiopathogenesis of stroke does not enhance statin prescription. | 24650199 |
| Acanthosis Nigricans, Skin lesion | Deregulated Nutrient Sensing | Acanthosis nigricans (AN) is an easily identifiable skin lesion and associated with insulin resistance. | 24650208 |
| Obesity | Deregulated Nutrient Sensing | Independent of obesity measures, greater fast-food restaurant density was associated with higher insulin resistance. | 24650840 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Reducing access to fast food and increasing public park space may be valuable to addressing insulin resistance and type 2 diabetes, but effects may vary by gender. | 24650840 |
| Diabetes, Autoimmune, Diabetes Mellitus | Deregulated Nutrient Sensing | Comparison of adults with insulin resistance (IR) in latent autoimmune diabetes versus IR in glutamic acid decarboxylase antibody-negative diabetes. | 24652431 |
| Diabetes, Autoimmune | Deregulated Nutrient Sensing | Insulin resistance in latent autoimmune diabetes in adults (LADA) patients is controversial. | 24652431 |
| diabetic | Deregulated Nutrient Sensing | The results showed that LADA patients had higher insulin resistance and high density lipoprotein cholesterol (HDLc) (P = 0.003 and 0.00017 respectively) and lower body mass index (BMI) (P = 0.007) compared to GAD-negative diabetic patients. | 24652431 |
| TG gene, Hypoalphalipoproteinemia, Familial, diabetic | Deregulated Nutrient Sensing | The HDLc was associated with decreased insulin resistance in LADA patients (P = 0.041), whereas HbA1c, triacylglycerides (TG) and waist were associated with increased insulin resistance in GAD-negative diabetic patients (P = 3.6x10-12, 1.01x10-5 and 0.004 respectively). | 24652431 |
| diabetic | Deregulated Nutrient Sensing | Insulin resistance is significantly higher in LADA than GAD-negative diabetic Malaysian subjects. | 24652431 |
| Periodontitis | Deregulated Nutrient Sensing | Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). | 24652728 |
| Non-alcoholic Fatty Liver Disease, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. | 24656140 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. | 24656140 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08-3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03-15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30-3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62-4.56); P < 0.01]. | 24656140 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Furthermore, maintained dyslipidemia was a strong predictor for CHD events. | 24657509 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Aberrant brain functional connectivity related to insulin resistance in type 2 diabetes: a resting-state fMRI study. | 24658392 |
| Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is characterized by insulin resistance, which is involved in the development of Alzheimer disease. | 24658392 |
| diabetic | Deregulated Nutrient Sensing | Type 2 diabetic patients develop aberrant functional connectivity of the PCC, which is associated with insulin resistance in selected brain regions. | 24658392 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A high prevalence of diabetes (57%), hypertension (56.6%), dyslipidemia (42%), and smoking (32.4%) was reported. | 24658552 |
| Congenital Abnormality, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | We identified novel associations between elevated CETP activity and the triad of quantitative and qualitative lipoprotein abnormalities in the atherogenic dyslipidemia in South Asians, a major contributor of increased atherosclerotic cardiovascular diseases in South Asians. | 24659026 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Omentin is a plasma adipokine that is synthesized in visceral adipose tissue; its plasma concentration changes in colorectal cancer and conditions associated with insulin resistance. | 24659266 |
| Patent ductus arteriosus - persisting type | Deregulated Nutrient Sensing | A syndrome of insulin resistance resembling Donohue syndrome with patent ductus arteriosus. | 24660547 |
| Patent ductus arteriosus - persisting type | Deregulated Nutrient Sensing | It is very rare that a syndrome of insulin resistance resembles Donohue syndrome with patent ductus arteriosus. | 24660547 |
| Patent ductus arteriosus - persisting type | Deregulated Nutrient Sensing | This child shows insulin resistance resembling Donohue syndrome with patent ductus arteriosus. | 24660547 |
| Diabetic Retinopathy, Dyslipidemias, Sex Characteristics, Polyneuropathy | Deregulated Nutrient Sensing | We report a series of novel OSAS-related sexual dimorphisms, concerning GAD65 auto-antibodies; polyneuropathy; atherogenic dyslipidemia [all increased in females]; diabetic retinopathy; North-Caucasian ethnicity; metabolic control; and TIA/stroke prevalence [all lower in females]. | 24661757 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Clustering of cardiometabolic risk factors was defined by the existence of 2 or more of high blood pressure, hyperglycemia, and dyslipidemia. | 24662439 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Logistic regression analysis was used to establish an association with and prognostic value of vitamin D for the onset of type 2 diabetes mellitus, as well as insulin resistance, body mass index (BMI), total cholesterol and triglyceride levels in the development of diabetes. | 24662713 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study showed that the patients with postmenopausal OS and hypovitaminosis D, besides a high BMI, elevated triglyceride levels and insulin resistance, had an increased risk of developing type 2 diabetes. | 24662713 |
| Psoriasis vulgaris | Deregulated Nutrient Sensing | Effect of treatment with methotrexate and coal tar on adipokine levels and indices of insulin resistance and sensitivity in patients with psoriasis vulgaris. | 24665910 |
| Psoriasis vulgaris | Deregulated Nutrient Sensing | Hence, we undertook to study adipokine levels and indices of insulin resistance and sensitivity in patients with psoriasis vulgaris, in comparison with controls and their association with disease severity and response to therapy. | 24665910 |
| Liver Dysfunction | Deregulated Nutrient Sensing | She also exhibited insulin resistance and liver dysfunction. | 24668897 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Increased BIF-IMT was associated with dyslipidemia, coronary heart disease and smoking. | 24669965 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Increased ICA-IMT was associated with dyslipidemia and stroke. | 24669965 |
| Dyslipidemias, Heart failure | Deregulated Nutrient Sensing | Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia. | 24670266 |
| Dyslipidemias, Chronic heart failure, Congestive heart failure | Deregulated Nutrient Sensing | The effects of eicosapentaenoic acid (EPA) on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear. | 24670266 |
| Dyslipidemias | Deregulated Nutrient Sensing | Only patients with dyslipidemia at baseline (entry) were treated with EPA. | 24670266 |
| Inflammation, Dyslipidemias, Congestive heart failure | Deregulated Nutrient Sensing | These data indicate that EPA treatment may improve the cardiac function and long-term prognosis of CHF patients with dyslipidemia, at least in part, due to reductions in inflammation and improvements in the endothelial function. | 24670266 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Reduced sex hormone-binding globulin (SHBG) concentration predicts insulin resistance and type 2 diabetes, but its association with cardiovascular disease (CVD) risk is unclear. | 24670886 |
| Dyslipidemias, Diabetes Mellitus, Hepatitis C, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Overall, female gender, older age, non-white race/ethnicity, and pre-existing hypertension, dyslipidaemia, obesity and hepatitis C infection were associated with higher risk of diabetes incidence. | 24673640 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | (1) Statistical difference was observed in dyslipidemia, hypertension and the history of diabetes in the two groups (P < 0.05). | 24674723 |
| Overweight | Deregulated Nutrient Sensing | [Insulin resistance in adolescents with and without overweight of a municipality of Great Florianopolis-SC]. | 24676067 |
| Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | Increased overweight prevalence among adolescents is linked to Diabetes mellitus type 2 and insulin resistance (IR). | 24676067 |
| Urolithiasis, Dyslipidemias | Deregulated Nutrient Sensing | To assess the association between dyslipidemia and urolithiasis, a propensity score-matching study was performed. | 24684546 |
| Dyslipidemias, Disease | Deregulated Nutrient Sensing | The controls, from a health-screening program, did not have a history of dyslipidemia or statin use and have any evidence of stone disease, as determined by abdominal radiography, ultrasonography examination. | 24684546 |
| Urinary Calculi, Dyslipidemias | Deregulated Nutrient Sensing | Our study implies that dyslipidemia may play a crucial part in urinary stone risk. | 24684546 |
| Dyslipidemias, Myocardial Ischemia, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAE, Comorbidity | Deregulated Nutrient Sensing | Hypertension, diabetes, ischemic heart disease, dyslipidaemia and respiratory problem were significantly associated co-morbid conditions in stroke patients (at 95% CI, p value is <0.001, <0.01, <0.001, <0.05, <0.05 respectively). | 24684800 |
| Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | From non-obese children, children under general-obesity, abdominal obesity and those with combined types of obesity, there appeared an increasing trend in the levels of blood pressure, blood glucose, and blood lipids, the prevalence dyslipidemia and hypertension (P < 0.001). | 24685027 |
| Cancer-related fatigue, Obesity, Abdominal, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | After controlling for age, sex, and puberty stage, when compared with non-obese children, those children with abdominal obesity or combined types of obesity had 1.54 and 2.51 times of risks to only one CRF, while generally obese children had similar risk of dyslipidemia. | 24685027 |
| Hypoglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Biochemical hypoglycaemia during an OGTT in the absence of diabetes or IGR was not associated with insulin resistance, but instead appeared to be associated with more favourable glycaemic risk profiles than IGR and NGT. | 24685116 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Observational data suggest that hyperglycaemia, hypertension and dyslipidaemia might be involved in the causal pathway underlying this link, but data from the ACCORD MIND investigators challenge these findings. | 24686200 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Hypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels: potential targets for an efficient preventive intervention. | 24686488 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | Therefore, in this study we compared the levels of insulin resistance (IR:OGIS), plasma insulin (PI:RIA) levels, and pro-inflammatory cytokines (IL-6 and TNF-a: ELISA), being risk factors previously found to be associated with hypertension, in T2D patients showing increased body weight (obese and overweight, BMI >= 25 kg/m2) with hypertension (group A, N = 30), or without hypertension (group B, N = 30), and in nonobese (BMI < 25 kg/m2), normotensive controls (group C, N = 15). | 24686488 |
| Non-alcoholic Fatty Liver Disease, Steatohepatitis, Weight decreased | Deregulated Nutrient Sensing | The addition of exercise to a diet regimen potentiates the benefits in NAFLD management through further improvement of hepatic steatosis, inflammatory and oxidative stress levels, and adipokine imbalance, thereby attenuating insulin resistance independent of detectable weight loss. | 24689911 |
| Glucose Intolerance (disease), Breast Carcinoma | Deregulated Nutrient Sensing | On the status and comparison of glucose intolerance in female breast cancer patients at initial diagnosis and during chemotherapy through an oral glucose tolerance test. | 24690937 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Associated profile: female (OR=0.460, P=0.091), no dyslipidemia (OR=0.393, P=0.048), no coronary heart disease (OR=0.215, P=0.001) and high diastolic blood pressure (OR=1.076, P=0.016). | 24694801 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Associated profile: male (OR=1.610, P=0.089), smoking (OR=2.055, P=0.045), dyslipidemia (OR=3.227, P<0.001) and diabetes (OR=2.795, P<0.001). | 24694801 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study reports association of CDKAL1-related SNPs with insulin resistance, a clinical marker related to type 2 diabetes in a cross-sectional cohort of Greek children and adolescents of European descent. | 24695378 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Both glucose intolerance and HbA(1c) levels increased with age. | 24698119 |
| Ventricular hypertrophy | Deregulated Nutrient Sensing | Left ventricular hypertrophy and insulin resistance in adults from an urban community in The Gambia: cross-sectional study. | 24705608 |
| Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | To determine the association between left ventricular hypertrophy and insulin resistance in Gambians. | 24705608 |
| Electrocardiogram: left ventricle hypertrophy (finding) | Deregulated Nutrient Sensing | Logistic regression analysis was used to determine the association between left ventricular hypertrophy and insulin resistance. | 24705608 |
| Antihypertensive Agents, Ventricular hypertrophy | Deregulated Nutrient Sensing | No association was found in this study between left ventricular hypertrophy and insulin resistance in Gambians and this does not support the suggestion that insulin is an independent determinant of left ventricular hypertrophy in hypertensives. | 24705608 |
| Liver Dysfunction, Liver Cirrhosis | Deregulated Nutrient Sensing | Insulin resistance as early sign of hepatic dysfunction in liver cirrhosis. | 24705764 |
| Glucose Intolerance (disease), Liver Dysfunction | Deregulated Nutrient Sensing | All patients with LC showed insulin resistance in both peripheral (skeletal and adipose) and hepatic tissues evaluated by HECGL, although significant correlation between the degree of glucose intolerance and the severity of hepatic dysfunction was not observed. | 24705764 |
| Liver parenchyma, Saint Lucia | Deregulated Nutrient Sensing | Insulin resistance in both liver and peripheral tissues is the early sign in the patients with LC. | 24705764 |
| Increased insulin level, Glucose Intolerance (disease), Saint Lucia, Hyperglycemia, Postprandial, Liver Cirrhosis | Deregulated Nutrient Sensing | Glucose intolerance characterized by postprandial hyperglycemia and hyperinsulinemia is commonly seen in patients with liver cirrhosis (LC). | 24705764 |
| Saint Lucia, Glucose Intolerance (disease), Liver function | Deregulated Nutrient Sensing | The aim of this study is to clarify the relation between glucose intolerance and disorder of liver function in patients with LC. | 24705764 |
| Electrocardiogram: myocardial infarction (finding), Myocardial Reperfusion | Deregulated Nutrient Sensing | Acute insulin resistance in ST-segment elevation myocardial infarction in non-diabetic patients is associated with incomplete myocardial reperfusion and impaired coronary microcirculatory function. | 24708817 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Insulin resistance (IR) assessed by the Homeostatic Model Assessment (HOMA) index in the acute phase of myocardial infarction in non-diabetic patients was recently established as an independent predictor of intrahospital mortality. | 24708817 |
| Obesity | Deregulated Nutrient Sensing | The aim of the present study was to examine to what extent different social network mechanisms are involved in the pathogenesis of obesity and insulin-resistance. | 24710599 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Social network phenomena appear not only to be relevant for the spread of obesity, but also for the spread of insulin resistance as the basis for type 2 diabetes. | 24710599 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was a most common risk factor present in 83% patients. | 24713427 |
| Hypertension, CTCAE, Atherosclerosis, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Hypertension and dyslipidemia were the most common risk factors and large vessel atherosclerosis was the most common stroke etiology. | 24713427 |
| Juvenile acne, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Based on clinical, histopathological and paraclinical examinations, we established the following diagnoses: ulcerated NL, type 1 DM, moderate mixed dyslipidemia, class I obesity; commissural candidiasis, juvenile acne. | 24715184 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Insulin resistance and other cardio-metabolic risk factors predict increased risk of depression and decreased response to antidepressant and mood stabilizer treatments. | 24715548 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Torc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models. | 24715588 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The [(13)c]glucose breath test is a reliable method to identify insulin resistance in Mexican adults without diabetes: comparison with other insulin resistance surrogates. | 24716853 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) precedes type 2 diabetes, but tests used to detect it in clinical settings reported poor reproducibility. | 24716853 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Obese children and adolescents have elevated nighttime blood pressure independent of insulin resistance and arterial stiffness. | 24717420 |
| Arterial Stiffness | Deregulated Nutrient Sensing | Obese children had a higher nighttime BP when compared with the control group independently of insulin resistance and arterial stiffness. | 24717420 |
| Arterial Stiffness | Deregulated Nutrient Sensing | No relationship was found between insulin resistance and arterial stiffness. | 24717420 |
| Asthma, Dyslipidemias, Depression, CTCAE | Deregulated Nutrient Sensing | The diagnosis of obesity-related conditions increased significantly with increasing BMI, with 33.5% of obese participants diagnosed with asthma, 7.9% diagnosed with dyslipidemia, and 7.2% diagnosed with depression. | 24717817 |
| Prehypertension | Deregulated Nutrient Sensing | The AGT and the GNB3 polymorphisms and insulin resistance in prehypertension. | 24722130 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Similarly, increased insulin resistance and lipidemia were more common in the hypertensive and prehypertensive populations. | 24722130 |
| Communicable Diseases, Infection, Hyperglycemia | Deregulated Nutrient Sensing | Increased risk of infection following hyperglycemia has been reported in hospitalized patients and infections may also cause insulin resistance which complicates the control of blood glucose level. | 24727515 |
| Dyslipidemias | Deregulated Nutrient Sensing | Over the course of 96 weeks, RPV-based therapy was associated with lower increases in lipid parameters and fewer dyslipidemia AEs than EFV-based treatment. | 24729492 |
| Neurodegenerative Disorders | Deregulated Nutrient Sensing | Insulin resistance and gray matter volume in neurodegenerative disease. | 24735819 |
| Neurodegenerative Disorders, palladium, Presenile dementia, Data types - Address, physiopathological | Deregulated Nutrient Sensing | This cross-sectional study suggests that insulin resistance is increased in neurodegenerative disease, and that individuals with AD appear to have more severe metabolic dysfunction than individuals with PD or PD dementia. | 24735819 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia and residual cardiovascular risk in statin-treated patients. | 24736236 |
| Dyslipidemias | Deregulated Nutrient Sensing | At least part of that risk may be attributable to atherogenic dyslipidemia characterized by low high-density lipoprotein cholesterol (<=40 mg/dL) and high triglycerides (triglycerides>=150 mg/dL). | 24736236 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | The presence of atherogenic dyslipidemia was associated with higher residual cardiovascular risk in PERFORM and SPARCL subjects with stroke or transient ischemic attack receiving statin therapy. | 24736236 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association of hematological parameters with insulin resistance in type 1 diabetes. | 24736486 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In a multiple logistic regression analysis after adjustment for age, sex, duration of diabetes and BMI, the presence of insulin resistance was independently associated with WBC count (odds ratio=1.28, P<0.01). | 24736486 |
| Inflammation | Deregulated Nutrient Sensing | The significant independent association of WBC with the presence of insulin resistance suggests a role of subclinical inflammation in its pathogenesis. | 24736486 |
| Structure of beta Cell of islet, Hyperactive behavior, Impaired | Deregulated Nutrient Sensing | Pancreatic b-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. | 24740570 |
| B-Lymphocytes | Deregulated Nutrient Sensing | Using a mouse model with b-cell-specific deletion of Tsc2 (bTsc2(-/-)) and, consequently, mTORC1 hyperactivation, we focused on the role that chronic mTORC1 hyperactivation might have on b-cell failure. | 24740570 |
| Hyperglycemia | Deregulated Nutrient Sensing | mTORC1 hyperactivation drove an early increase in b-cell mass that later declined, triggering hyperglycemia. | 24740570 |
| B-Lymphocytes, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | We provide evidence of b-cell autophagy impairment as a link between mTORC1 hyperactivation and mitochondrial dysfunction that probably contributes to b-cell failure. | 24740570 |
| Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Renalase might be associated with hypertension and insulin resistance in Type 2 diabetes. | 24742207 |
| melanoma | Deregulated Nutrient Sensing | SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells. | 24742694 |
| Neoplasms | Deregulated Nutrient Sensing | SIRT1 operates as both a tumor suppressor and oncogenic factor depending on the cell context. | 24742694 |
| melanoma | Deregulated Nutrient Sensing | Whether SIRT1 plays a role in melanoma biology remained poorly elucidated. | 24742694 |
| melanoma | Deregulated Nutrient Sensing | Here, we demonstrate that SIRT1 is a critical regulator of melanoma cell proliferation. | 24742694 |
| melanoma | Deregulated Nutrient Sensing | SIRT1 over-expression relieves the senescence-like phenotype and the proliferation arrest caused by MITF suppression, demonstrating that SIRT1 is an effector of MITF-induced proliferation in melanoma cells. | 24742694 |
| melanoma | Deregulated Nutrient Sensing | Interestingly, SIRT1 level and activity are enhanced in the PLX4032-resistant BRAF(V600E)-mutated melanoma cells compared with their sensitive counterpart. | 24742694 |
| melanoma | Deregulated Nutrient Sensing | SIRT1 inhibition decreases melanoma cell growth and rescues the sensibility to PLX4032 of PLX4032-resistant BRAF(V600E)-mutated melanoma cells. | 24742694 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, type 2 diabetes mellitus, impaired glucose tolerance, and dyslipidemia were of a similar frequency in both groups. | 24743396 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | She had a background of diabetes mellitus, hypertension and dyslipidaemia. | 24744069 |
| Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Association of dietary factors with insulin resistance and inflammatory markers in subjects with diabetes mellitus and coronary artery disease in Indian population. | 24746438 |
| Inflammation, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) and inflammation have been implicated in pathogenesis of diabetes and cardiovascular disease. | 24746438 |
| Inflammation | Deregulated Nutrient Sensing | Dietary factors have been reported to be associated to insulin resistance and inflammation. | 24746438 |
| Neurobehavioral Manifestations, Depression, CTCAE | Deregulated Nutrient Sensing | Differential association of insulin resistance with cognitive and somatic symptoms of depression. | 24754892 |
| Neurobehavioral Manifestations, Bipolar Disorder | Deregulated Nutrient Sensing | To examine the associations of depressive symptoms with insulin resistance, evaluating somatic and cognitive depressive symptoms separately. | 24754892 |
| Bipolar Disorder, Cognitive | Deregulated Nutrient Sensing | Somatic depressive symptoms seem to be more strongly associated with insulin resistance than do cognitive depressive symptoms. | 24754892 |
| Bipolar Disorder, Depressed mood, Cognitive | Deregulated Nutrient Sensing | Monitoring somatic depressive symptoms may be more appropriate than monitoring cognitive depressive symptoms among depressed individuals with high insulin resistance. | 24754892 |
| Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | [Association between serum lipoprotein lipase level and dyslipidemia in patients with obstructive sleep apnea syndrome]. | 24754980 |
| Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | To explore the association between serum lipoprotein lipase (LPL) level and dyslipidemia in patients with obstructive sleep apnea syndromes (OSAS). | 24754980 |
| Sleep Apnea, Obstructive, Dyslipidemias | Deregulated Nutrient Sensing | Thus LPL may play some roles in dyslipidemia of OSAS patients. | 24754980 |
| Inflammation, Heart failure | Deregulated Nutrient Sensing | Various adipokines are reported to be associated with the development of heart failure (HF) through insulin resistance and chronic inflammation. | 24755035 |
| Liver Dysfunction, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Subjects with the C5 variant had higher age, lower body mass index, milder dyslipidemia and liver dysfunction, and lower rates of hypertension and CAD compared with subjects without the C5 variant. | 24755128 |
| Hepatitis C | Deregulated Nutrient Sensing | The impact of pegylated interferon and ribavirin combination treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients. | 24757657 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C | Deregulated Nutrient Sensing | Lipid profile and insulin resistance (IR) are associated with hepatitis C virus (HCV) and may predict the chronic hepatitis C (CHC) treatment response. | 24757657 |
| Sialorrhea | Deregulated Nutrient Sensing | Furthermore, eradication of HCV may improve whole-body IR and insulin hypersecretion, as well as high baseline insulin resistance (HOMA-IR >2.5). | 24757657 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Patients with non-alcoholic fatty liver had higher (p < 0.001) mean values of urinary 8-iso-PGF2a and of serum soluble NOX2-derived peptide, alanine aminotransferase, Cytokeratin-18 and homeostasis model of insulin resistance and lower values of serum adiponectin as compared to those without. | 24758604 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Complement factor 3 is associated with insulin resistance and with incident type 2 diabetes over a 7-year follow-up period: the CODAM Study. | 24760264 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Immune dysregulation can affect insulin resistance (IR) and b-cell function and hence contribute to development of type 2 diabetes mellitus (T2DM). | 24760264 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The objectives of the study were to determine dyslipidaemia prevalence in first episode coronary heart disease cases and to determine the pattern of distribution of risk factors in this temporal relationship. | 24761497 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidaemia was present in 67.6% of first episode coronary heart disease cases. | 24761497 |
| Heart Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Heart disease patients with history of diabetes showed a high prevalence of dyslipidaemia (100%), the association being statistically significant (p = 0.008). | 24761497 |
| Overweight | Deregulated Nutrient Sensing | Compared with overweight children, those who were obese were more likely to have the two conditions: acanthosis nigricans (59% vs 44%; P=0.005) and insulin resistance (35% vs 19%; P=0.001). | 24762331 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Obese Chinese children and adolescents with acanthosis nigricans had a higher chance of having insulin resistance and cardiometabolic co-morbidities. | 24762331 |
| Non-alcoholic Fatty Liver Disease, Weight decreased, Hypertransaminasaemia | Deregulated Nutrient Sensing | We showed that weight reduction secondary to two hypocaloric diets was associated with improvement in hypertransaminasemia and insulin resistance in NAFLD patients. | 24763885 |
| Obesity, diabetic | Deregulated Nutrient Sensing | Although previous studies have indicated that insulin resistance may play a role in the pathogenesis of both lesions in diabetic and obese patients, we found no indication of a relationship in nondiabetic and nonobese patients with increased levels of EGF in patients with ST, suggesting an alternative pathogenesis in this patient group. | 24763889 |
| Senile sclerosis of aortic cusp | Deregulated Nutrient Sensing | Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis. | 24767168 |
| Senile sclerosis of aortic cusp | Deregulated Nutrient Sensing | However, in patients with aortic valve sclerosis (AVS), the association between insulin resistance and subclinical impairment of LV function is not fully elucidated. | 24767168 |
| Left Ventricular Hypertrophy, physiopathological, Obesity, Visceral | Deregulated Nutrient Sensing | Insulin resistance is a powerful independent predictor of subclinical LV dysfunction regardless of concomitant visceral obesity and LV hypertrophy. | 24767168 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We aimed to elucidate the risk factors for the development of NODM and those for progressive glucose intolerance in adult living-donor liver transplant (LDLT) recipients. | 24767367 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | NODM and post-transplantation glucose intolerance had no negative impact on patient and graft outcomes. | 24767367 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In stepwise logistic regression analysis adjusted for diabetes, hypertension, dyslipidemia and age, visfatin (p=0.026) and ghrelin (p=0.012) proved to be independent predictors of AIS. | 24768795 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Factors associated with therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia. | 24769787 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are the most prevalent cardiovascular risk factors, with approximately 30 million patients in the United States having these concomitant conditions. | 24769787 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | These variations in therapeutic goal attainment in patients with concomitant hypertension and dyslipidemia across different BMI groups suggest that future research is needed to determine the underlying reasons for these disparities. | 24769787 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | Association between phosphorylated AMP-activated protein kinase and acetyl-CoA carboxylase expression and outcome in patients with squamous cell carcinoma of the head and neck. | 24769813 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | AMP-activated protein kinase (AMPK) regulates glucose and lipid metabolism via the phosphorylation and subsequent inactivation of its downstream target acetyl-CoA carboxylase (ACC).Thus, we analyzed the expression of pAMPK and its downstream target phosphorylated acetyl-CoA carboxylase (pACC), as well as their impact on the survival of patients with resected SCCHN. | 24769813 |
| Behavior, Primary malignant neoplasm | Deregulated Nutrient Sensing | For example, the LKB1-AMPK-mTOR signaling pathway genes are already known to alter the cell metabolism and to play a critical role in the malignant behavior of cancer. | 24770722 |
| Obesity | Deregulated Nutrient Sensing | Dysregulation of 11b-hydroxysteroid dehydrogenase (11b-HSD) enzyme activities are implicated in the pathogenesis of obesity and insulin resistance. | 24771091 |
| Inflammation, Thrombosis | Deregulated Nutrient Sensing | Inflammation has been associated with insulin resistance, type 2 diabetes mellitus (T2DM), and atherothrombosis. | 24772446 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertension (49%) and dyslipidemia (36%) were the most common underlying cardiovascular diseases (CVDs). | 24772588 |
| Atrial Fibrillation, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | For Thai patients with AF, hypertension and dyslipidemia were the most common underlying CVDs, and rate control was the preferred treatment strategy. | 24772588 |
| Dyslipidemias | Deregulated Nutrient Sensing | Mean BMI was 26.8 +/- 4.7 kg/m2, co-morbid diseases were as follows; DM, 68 patients (57.1%) and dyslipidemia 67 patients (56.3%). | 24772590 |
| Vascular Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Patients with porcelain aorta more frequently had extracardiac vascular disease (11 [30.6%] vs 49 [11.9%]; P=.002), prior coronary revascularization (15 [41.7%] vs 98 [23.7%]; P=.017), and dyslipidemia (26 [72.2%] vs 186 [45%]; P=.02). | 24773857 |
| Dyslipidemias, Obesity, Choline Dehydrogenase, Mitochondrial, Asthma, Hypertension, CTCAE | Deregulated Nutrient Sensing | RFs, such as female gender, family history, hypertension, obesity and dyslipidemia play an important role in the development of asthma concurrent with CHD. | 24779068 |
| Inflammation | Deregulated Nutrient Sensing | Resistin is an adipocytokine that has been related to inflammation and insulin resistance. | 24780007 |
| Degenerative polyarthritis, ETV3 wt Allele | Deregulated Nutrient Sensing | The association between MetS and radiographic knee OA can be largely explained by an excessive weight but not by insulin resistance, a key pathophysiology of MetS. | 24780047 |
| Hepatitis C | Deregulated Nutrient Sensing | Taken together, this study provided information on the proteome profile of the HCV-infected Indian population, and revealed a link between HCV infection, RBP4 and insulin resistance. | 24784414 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Effects of age on insulin resistance and secretion in subjects without diabetes. | 24785884 |
| Hypertensive (finding), Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Persistent lipid abnormalities in patients with hypertension and dyslipidemia treated with statins: results of the Portuguese hypertensive subpopulation of the Dyslipidemia International Study (DYSIS). | 24785978 |
| Vascular Diseases, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Other traditional CRFs (hypertension, dyslipidaemia, smoking, age and family history of vascular disease) were not associated with CAD severity. | 24786377 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | We tested if dyslipidemia is a risk factor for coronary artery disease in the Lebanese population, and studied the role of the total cholesterol/HDL cholesterol (TC/HDL-C) ratio as a biological marker of coronary artery disease. | 24788070 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Metabolic syndrome, but not insulin resistance, is associated with an increased risk of renal function decline. | 24792685 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Association between alcohol intake, overweight, and serum lipid levels and the risk analysis associated with the development of dyslipidemia. | 24793348 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | To study the association of alcoholic intake, overweight, and dyslipidemia. | 24793348 |
| Fatty Liver, Dyslipidemias, Hyperuricemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Metabolically unhealthy individuals were defined as people with biological features of dyslipidemia, hyperuricemia, diabetes, and/or hepatitis steatosis. | 24794756 |
| Hyperglycemia, diabetic, Cerebral Small Vessel Diseases, Hypoglycemia, Brain Injuries | Deregulated Nutrient Sensing | To avoid brain injury in diabetic elderly patients, management of hypoglycemia, hyperglycemia, fluctuation of blood glucose, insulin resistance, and cerebral vessel disease is crucial. | 24796099 |
| Prediabetes syndrome, Anhidrosis | Deregulated Nutrient Sensing | Several studies have identified a link between sudomotor dysfunction, insulin resistance, and pre-diabetes. | 24798863 |
| Gastrointestinal inflammation, Ulcerative Colitis | Deregulated Nutrient Sensing | RBP-4 serum levels were also high in acute and chronic intestinal inflammation in UC and CD, which can support insulin resistance. | 24799023 |
| Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | After controlling for age, sex, BMI, waist circumference, hypertension, serum HDL, triglyceride and CRP level and insulin resistance, Hispanics of Mexican origin remained significantly more likely to have NAFLD than those of Dominican and Puerto Rican origin. | 24803810 |
| TG gene, Dyslipidemias, AURKAIP1 gene | Deregulated Nutrient Sensing | Dyslipidemia in group 3 was demonstrated by higher TG levels, lipid ratios and AIP and lower HDL-C levels compared with group 2. | 24804368 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In total, 25% of the probands had elevated homeostatic assessment of insulin resistance values, and 58.3% of these had evidence of concomitant Type 2 diabetes in their family. | 24804978 |
| Inflammation, Units Of Measure - Siemens | Deregulated Nutrient Sensing | Considering insulin resistance and inflammation, the prevalence of MHO was 38.4%. | 24811744 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Sleep duration and insulin resistance in individuals without type 2 diabetes: the PPP-Botnia study. | 24813456 |
| Sleeplessness, Sleep Apnea, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | We studied if short and long sleep durations were associated with insulin resistance (IR) and insulin secretion in individuals without diabetes, and if the associations remained after we excluded individuals who reported more frequent and severe complaints of sleep apnea and insomnia. | 24813456 |
| Mitochondrial abnormalities | Deregulated Nutrient Sensing | The mitochondrial abnormalities appear to be caused by decreased activation of the NAD(+)-SIRT1-PGC-1a axis triggered by hyperactivation of the DNA damage sensor PARP-1. | 24813611 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our results suggest that gender, behavioral factors, and dyslipidemia may affect the risk for developing rectal NETs. | 24813818 |
| Dyslipidemias | Deregulated Nutrient Sensing | The findings of this study contribute to a better understanding of the influence of gender, behavioral factors, and dyslipidemia in developing rectal NETs. | 24813818 |
| Adenocarcinoma of large intestine | Deregulated Nutrient Sensing | Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. | 24816737 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | However, the correlations between SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear. | 24816737 |
| Adenoma, Secondary malignant neoplasm of liver, Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 protein expression in a paraffin-embedded tissue microarray, including 13 benign adenomas, nine liver metastasis tissues, and 120 paired colorectal cancer and normal mucosa tissues, was measured by immunohistochemistry. | 24816737 |
| Malignant tumor of colon | Deregulated Nutrient Sensing | SIRT1 mRNA and protein expression in colon cancer cell lines with different metastatic potential and normal colon cells were detected by real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting. | 24816737 |
| Adenocarcinoma | Deregulated Nutrient Sensing | There was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissues (P < 0.01, kh(2) test). | 24816737 |
| Secondary malignant neoplasm of liver | Deregulated Nutrient Sensing | SIRT1 overexpression was more frequently observed in advanced-stage tumors and lymph node or liver metastases (P = 0.046, 0.002, and 0.004, respectively, kh(2) test). | 24816737 |
| Aggressive course | Deregulated Nutrient Sensing | SIRT1 expression was also significantly elevated in the more aggressive colon cancer cell line SW620. | 24816737 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 may play an important role in the progression of colorectal cancer. | 24816737 |
| Metabolic Diseases, Polycystic Ovary Syndrome, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Insulin resistance (IR) and metabolic disorders are common in polycystic ovary syndrome (PCOS). | 24816947 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | The association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined. | 24816996 |
| Dyslipidemias, Dysglycemia, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. | 24817067 |
| Presenile dementia, Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance (IR) is a putative risk factor for cognitive decline and dementia, and has been shown to impede neuronal glucose metabolism in animal models. | 24819305 |
| Hypertriglyceridemia, Hypocholesterolemia, Diabetes Mellitus | Deregulated Nutrient Sensing | (ii) After adjusted for age, individuals with diabetes by OGTT criteria but not by WHO HbA1c criteria had an increased chance of having abnormal weight, hypertriglyceridaemia, HDL hypocholesterolaemia and insulin resistance. | 24821380 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes. | 24824245 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Incident diabetes prevented these improvements, and this was accounted for by differences in weight, insulin resistance, and glucose levels. | 24824548 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | Phase 3, 12-week, randomized, double-blind, placebo- and ezetimibe-controlled study conducted between January and December of 2013 in patients with primary hypercholesterolemia and mixed dyslipidemia at 198 sites in 17 countries. | 24825642 |
| Dyslipidemias, Primary hypercholesterolemia | Deregulated Nutrient Sensing | In this 12-week trial conducted among patients with primary hypercholesterolemia and mixed dyslipidemia, evolocumab added to moderate- or high-intensity statin therapy resulted in additional LDL-C lowering. | 24825642 |
| Hypertension, CTCAE, Atherosclerosis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with more severe atherosclerosis were older (p<0.001), more likely to be obese (p=0.01), smokers (p=0.008) and have hypertension (p=0.001), diabetes (p<0.0001) and dyslipidaemia (p<0.0001). | 24827532 |
| physiopathological | Deregulated Nutrient Sensing | Insulin resistance and higher leptin may be early markers of metabolic dysfunction associated with SSBs. | 24828025 |
| Hypogonadism | Deregulated Nutrient Sensing | The correlations found between testosterone and four of the five components of MS, as well as with BMI and TG/HDL-chol ratio, a surrogate marker of insulin resistance, suggest considering male hypogonadism as a determinant of developmental abnormalities typical of MS. | 24828370 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Therefore, the management of dyslipidemia, together with glucose control, may be beneficial for T2DM with hyperlipidemia. | 24829924 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Ketosis onset type 2 diabetes had better islet b-cell function and more serious insulin resistance. | 24829925 |
| Ketosis | Deregulated Nutrient Sensing | This case control study was aimed at comparing the clinical characteristic, b-cell function, and insulin resistance of ketosis and nonketotic onset T2DM and providing evidence for treatment selection. | 24829925 |
| Ketosis | Deregulated Nutrient Sensing | From these data, we concluded that ketosis onset T2DM had better islet b-cell function and more serious insulin resistance than nonketotic onset T2DM. | 24829925 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) is regarded as one of the earliest features of many metabolic diseases, and major efforts are aimed at improving insulin function to confront this issue. | 24830843 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The gap between the current dyslipidemia guidelines and the physicians' treatment targets in patients with type 2 diabetes in Turkey. | 24831765 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study evaluated the management of dyslipidemia in patients with type 2 diabetes in real life. | 24831765 |
| Osage language, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidaemia has been implicated as a mechanism linking OSA with atherosclerosis, but no consistent associations with lipids exist for OSA or positive airway pressure treatment. | 24833762 |
| Cardiovascular morbidity, Dyslipidemias, Diabetes Mellitus, Malignant Neoplasms, Obesity, Hypertension, CTCAE, Disease | Deregulated Nutrient Sensing | These results suggest that exposure to Holocaust conditions in early life may be associated with a higher prevalence of obesity, dyslipidemia, diabetes, hypertension, cardiovascular morbidity, malignancy and peptic diseases in adulthood. | 24834754 |
| Erectile dysfunction | Deregulated Nutrient Sensing | Insulin resistance is an independent predictor of severe lower urinary tract symptoms and of erectile dysfunction: results from a cross-sectional study. | 24836928 |
| Lower Urinary Tract Symptoms | Deregulated Nutrient Sensing | We strongly suggest to prevent LUTS and ED by reducing insulin resistance. | 24836928 |
| Obesity | Deregulated Nutrient Sensing | [Some peculiarities in the manifestation of oxidative stress and current status of antioxidant system in adolescents of different age groups with obesity, complicated by insulin resistance and without it]. | 24837315 |
| Obesity | Deregulated Nutrient Sensing | Obesity with concomitant insulin resistance increases manifestations of oxidative stress accompanied by a compensatory increase in the activity of catabolic enzymes and reduced capacity of the defense antioxidant system in late puberty. | 24837315 |
| Primary malignant neoplasm, Dyslipidemias, Myocardial Ischemia, Diabetes Mellitus, Electrocardiogram abnormal, Chronic Obstructive Airway Disease, Heart failure, Cessation of life, Hypertension, CTCAE | Deregulated Nutrient Sensing | After adjustment for age, gender, race/ethnicity, IHD, heart failure, chronic obstructive pulmonary disease, cancer, diabetes, body mass index, smoking, dyslipidemia, hypertension, use of antihypertensive and lipid-lowering medications, and ECG abnormalities, DTNPV1 was associated with significantly increased risk of all-cause death (HR [95% CI]: 1.30 [1.10, 1.53]; P = 0.002), CVD death (HR [95% CI]: 1.36 [1.08, 1.72]; P = 0.010), and IHD death (HR [95% CI]: 1.36 [1.00, 1.85]; P = 0.047). | 24837486 |
| Chronic Kidney Diseases, Ventricular hypertrophy | Deregulated Nutrient Sensing | Effects of insulin resistance on left ventricular hypertrophy in patients with CKD stage 1-3. | 24839054 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Homeostatic model assessment of insulin resistance was calculated in participants without diabetes. | 24839195 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in addition to diabetes and dyslipidemia in a multivariate analysis. | 24845468 |
| Diabetes Mellitus, Insulin-Dependent, Insulin | Deregulated Nutrient Sensing | Individuals with type 1 diabetes may have low IGF-1, related to insulinopenia and insulin resistance. | 24845759 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Depressive symptom clusters as predictors of 6-year increases in insulin resistance: data from the Pittsburgh Healthy Heart Project. | 24846000 |
| Prediabetes syndrome, Bipolar Disorder | Deregulated Nutrient Sensing | To examine longitudinal bidirectional associations between two depressive symptom clusters-the cognitive-affective and somatic-vegetative clusters--and insulin resistance, a marker of prediabetes. | 24846000 |
| Depression, CTCAE, Fatigue, Dyssomnias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among adults aged 50 to 70 years, the somatic-vegetative symptoms of depression (e.g., fatigue, sleep disturbance, and appetite changes) may worsen insulin resistance and increase diabetes risk, partly, by increasing body mass index. | 24846000 |
| Osteoporosis, Chronic Kidney Diseases, Sarcopenia | Deregulated Nutrient Sensing | Early-stage chronic kidney disease, insulin resistance, and osteoporosis as risk factors of sarcopenia in aged population: the fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008-2009. | 24846317 |
| Osteoporosis, Kidney Diseases, Sarcopenia | Deregulated Nutrient Sensing | In this study, we found that insulin resistance, chronic kidney disease stage 3, and osteoporosis at the femur neck were closely associated with sarcopenia in elderly men. | 24846317 |
| Chronic Kidney Diseases, Osteoporosis, Muscle (organ) | Deregulated Nutrient Sensing | Insulin resistance, chronic kidney disease, and osteoporosis at the femur neck should be modified to prevent the acceleration of skeletal muscle loss in elderly men. | 24846317 |
| Endotoxemia, Sarcopenia | Deregulated Nutrient Sensing | In conclusion, insulin resistance and sarcopenia of aging are associated with increased TLR4 expression/signaling, which may be secondary to metabolic endotoxemia. | 24846769 |
| Hyperhomocysteinemia, Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Congenital heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Hyperglycemia, dyslipidemia and hyperhomocysteinemia are associated with both adult cardiovascular disease (CVD) and having a child with a congenital heart disease (CHD). | 24847701 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | However, in the absence of dyslipidaemia, raised CRP can still be considered as a strong predictor of CAD and stroke. | 24848386 |
| Steatohepatitis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Carriers of the mutation had dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. | 24848981 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Vitamin D (Vit D) deficiency may be linked to the development of obesity-associated complications such as insulin resistance and type 2 diabetes. | 24849007 |
| Inflammatory Bowel Diseases | Deregulated Nutrient Sensing | Here we examined the expression, regulation, and function of SIRT1 in IBD. | 24850427 |
| Inflammatory Bowel Diseases | Deregulated Nutrient Sensing | SIRT1 RNA and protein expression was less pronounced in whole biopsies and lamina propria mononuclear cells (LPMCs) of IBD patients in comparison with normal controls. | 24850427 |
| Inflammatory Bowel Diseases, Tumor necrosis | Deregulated Nutrient Sensing | SIRT1 expression was downregulated in control LPMC by tumor necrosis factor (TNF)-a and interleukin (IL)-21, and upregulated in IBD LPMC by neutralizing TNF-a and IL-21antibodies. | 24850427 |
| Inflammatory Bowel Diseases | Deregulated Nutrient Sensing | Consistently, SIRT1 expression was increased in mucosal samples taken from IBD patients successfully treated with Infliximab. | 24850427 |
| Inflammatory Bowel Diseases | Deregulated Nutrient Sensing | Treatment of IBD LPMC with Cay10591, a specific SIRT1 activator, reduced NF-kB activation and inhibited inflammatory cytokine synthesis, whereas Ex527, an inhibitor of SIRT1, increased interferon (IFN)-g in control LPMC. | 24850427 |
| Colitis | Deregulated Nutrient Sensing | SIRT1 was also reduced in mice with colitis induced by 2,4,6-trinitrobenzenesulphonic acid or oxazolone. | 24850427 |
| Inflammatory Bowel Diseases | Deregulated Nutrient Sensing | Data indicate that SIRT1 is downregulated in IBD patients and colitic mice and suggest that SIRT1 activation can help attenuate inflammatory signals in the gut. | 24850427 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Consequently, a greater number suffered from dyslipidaemia, diabetes and hypertension. | 24852888 |
| Apolipoproteins B, Dyslipidemias | Deregulated Nutrient Sensing | Effects of extended-release niacin/laropiprant, simvastatin, and the combination on correlations between apolipoprotein B, LDL cholesterol, and non-HDL cholesterol in patients with dyslipidemia. | 24855368 |
| Dyslipidemias | Deregulated Nutrient Sensing | Greater dissociation of apoB, LDL-C, and non-HDL-C targets occur following treatment with ERN/LRPT, SIMVA, and ERN/LRPT + SIMVA in patients with dyslipidemia. | 24855368 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | In the present study, we found that, in human colorectal cancer cells, low-dose camptothecin (CPT) simultaneously induced autophagy and premature senescence through AMPK-TSC2-mTOR pathway and ATM-Chk2-p53-p21 pathway respectively. | 24858802 |
| Carotid Atherosclerosis, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Cumulative effects of hypertension, dyslipidemia, and chronic kidney disease on carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus. | 24860832 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The presence of hypertension, dyslipidemia, and chronic kidney disease (CKD) was documented in 106 Chinese subjects with type 2 diabetes. | 24860832 |
| Dyslipidemias, Hypertension, CTCAE, Dental Plaque, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and CKD in Chinese patients with type 2 diabetes have cumulative effects on the burden of carotid plaque. | 24860832 |
| Glucose Intolerance (disease), Overweight, Obesity | Deregulated Nutrient Sensing | Eighteen patients with overweight or obesity and glucose intolerance were invited to participate in an exercise program consisting in three sessions per week for 3 months. | 24861112 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Blood pressure, dyslipidaemia and diabetes were controlled in 47.5%, 37.4% and 43.8% of the population who were treated for the respective risk factors, with more than one-fourth of the controlled patients remaining at high risk. | 24862614 |
| Large prostate, ETV3 wt Allele | Deregulated Nutrient Sensing | Our results suggest that MetS, BMI, low HDL-C level, increased serum insulin and especially insulin resistance are considered risk factors for prostate enlargement in elderly Chinese men. | 24862628 |
| Albuminuria, diabetic | Deregulated Nutrient Sensing | To investigate the associations of 25-(OH)D and b -cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients. | 24868538 |
| Albuminuria, diabetic | Deregulated Nutrient Sensing | 25-(OH)D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated with b-cell function or insulin resistance. | 24868538 |
| Prediabetes syndrome, Dyslipidemias, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Taken together, these data suggest that SLE may play an important role in improving blood glucose, insulin resistance, adiposity, and dyslipidemia in prediabetes subjects consuming their habitual diet, similar to or better than BE. | 24873894 |
| diabetic | Deregulated Nutrient Sensing | Vildagliptin compared to glimepiride on post-prandial lipemia and on insulin resistance in type 2 diabetic patients. | 24874591 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | TPA was also more strongly associated with dyslipidemia and hypertension compared to cIMT. | 24876099 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Evaluation of target-directed treatment of dyslipidemia and diabetes mellitus demonstrated suboptimal control, with only 66% and 54% of patients, respectively, achieving the recommended therapeutic targets. | 24877186 |
| Cardiovascular morbidity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance predicts early cardiovascular morbidity in men without diabetes mellitus, with effect modification by physical activity. | 24879358 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | to assess how well insulin resistance predicts cardiovascular disease (CVD) in non-diabetic men and women and to explore the influence of physical activity. | 24879358 |
| Metabolic Diseases, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | In men elevated estradiol levels and associated metabolic disorders have been implicated in the development of common diseases including cardiovascular disorders, insulin resistance and type 2 diabetes mellitus, as increased estradiol associated with decreased testosterone levels increases the risk of these diseases. | 24880967 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Do static and dynamic insulin resistance indices perform similarly in predicting pre-diabetes and type 2 diabetes? | 24882014 |
| Prediabetes syndrome, Demographics Domain | Deregulated Nutrient Sensing | We designed a study to compare the predictive power of static and dynamic insulin resistance indices for categorized pre-diabetes (PDM)/type 2 diabetes (DM). | 24882014 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Chronic disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. | 24886552 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer. | 24890145 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | However, the correlations among SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear. | 24890145 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray, including 120 paired colorectal cancer and normal mucosa tissues. | 24890145 |
| Adenocarcinoma | Deregulated Nutrient Sensing | There was significant difference in SIRT1 overexpression between adenocarcinomas and normal mucosal tissue (P < 0.01, kh(2) test). | 24890145 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 may play an important role in the progression of colorectal cancer. | 24890145 |
| Fatty Liver, Dyslipidemias | Deregulated Nutrient Sensing | Normal circulating lipids, rates of hepatic de novo lipogenesis and appropriate hepatic triglyceride content for degree of adiposity in the patients we describe suggest that even lifelong GCK activation in isolation is insufficient to produce fatty liver and metabolic dyslipidaemia. | 24890200 |
| Ascites, Toxic effect, Hyperglycemia, Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | The most common grade 3 to 4 toxicities were hypertension, glucose intolerance, ascites, ALT elevation, hyperglycemia and thrombosis/embolism. | 24890858 |
| Neoplasms | Deregulated Nutrient Sensing | AMP-activated protein kinase (AMPK) has a central role in cellular energy sensing and is activated in preclinical tumour models following anti-vascular endothelial growth factor (VEGF) therapy. | 24892446 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab. | 24892446 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The possible predictive or prognostic role of AMPK status in cancer patients treated with anti-VEGF drugs has not been investigated so far. | 24892446 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Expression of components of the AMPK pathway including phosphorylated AMPK (pAMPK), phosphorylated acetyl-Coa carboxylase (pACC) and liver kinase B1 (LKB1) was investigated by immunohistochemistry in 48 colorectal cancers treated with FOLFIRI plus bevacizumab. | 24892446 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Our findings suggest that high tissue AMPK activation is a prognostic biomarker in this cohort of metastatic colorectal cancer patients. | 24892446 |
| Dental Plaque, Data types - Address, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | These findings suggest that a reduction in plaque burden and mitochondrial dysfunction through the activation of AMPK may be one of the mechanisms by which quercetin improves cognitive functioning in the APPswe/PS1dE9 transgenic mouse model of AD. | 24893798 |
| Diabetic Retinopathy | Deregulated Nutrient Sensing | Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. | 24894401 |
| Diabetic Retinopathy | Deregulated Nutrient Sensing | The goal of this study is to investigate the role of Sirt1 in the activation of MMP-9 in diabetic retinopathy. | 24894401 |
| Mitochondrial Damage, Hyperglycemia | Deregulated Nutrient Sensing | The effect of hyperglycemia and Sirt1 activator, resveratrol, on acetylation of p65 and its binding at MMP-9 promoter-and mitochondrial damage and apoptosis-was assessed in the retinal endothelial cells. | 24894401 |
| diabetic | Deregulated Nutrient Sensing | Retina from wild-type diabetic mice presented similar decrease in Sirt1, and diabetic mice with Sod2 overexpression or MMP-9 deletion had normal retinal Sirt1. | 24894401 |
| Diabetic Retinopathy | Deregulated Nutrient Sensing | Retinal microvasculature from human donors with established diabetic retinopathy also had decreased Sirt1. | 24894401 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, in diabetes, increase in oxidative stress inhibits Sirt1 and p65 is hyperacetylated, increasing the binding of p65 at MMP-9 promoter. | 24894401 |
| Diabetic Retinopathy | Deregulated Nutrient Sensing | Prevention of Sirt1 inhibition, via modulating acetylation of p65, should protect activation of MMP-9 and inhibit the development of diabetic retinopathy. | 24894401 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. | 24895271 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well. | 24895271 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia was found in 188 (37.2%), diabetes in 101 (20%) and smoking in 36 (7.1%). | 24897474 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance, the metabolic syndrome, and type 2 diabetes. | 24898240 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Because many non-Western immigrants in the Netherlands are vitamin D deficient, obese, and at high risk of diabetes, vitamin D supplementation may contribute to prevent diabetes and insulin resistance. | 24898240 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies. | 24898282 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | We have reported that a low serum lipoprotein lipase (LPL) mass level reflects insulin resistance and may be a risk factor for atherosclerotic diseases. | 24898600 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Therefore, LPL may represent a link between low adiponectin and dyslipidemia found in metabolic syndrome and type 2 diabetes mellitus. | 24905278 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | All the aforementioned results resulted from AMPK activation, but a residual activity of metformin after AMPK blockade was still noticeable even after inhibition of AMPK by compound C. Authors believe that metformin-based therapy, a cornerstone in diabetes therapy, not only improves the prognosis of diabetics by reducing blood glucose but also by reducing oxidative stress, inflammatory cytokine production and the shift toward alternative activation of macrophages. | 24905518 |
| Beta-cell dysfunction | Deregulated Nutrient Sensing | Insulin resistance and beta-cell dysfunction are involved in the pathogenesis of T2DM. | 24906975 |
| Non-alcoholic Fatty Liver Disease, Beta-cell dysfunction | Deregulated Nutrient Sensing | Insulin resistance is associated with NAFLD but little is known about beta-cell dysfunction and NAFLD. | 24906975 |
| Non-alcoholic Fatty Liver Disease, Beta-cell dysfunction | Deregulated Nutrient Sensing | The association of NAFLD severity with beta-cell dysfunction is stronger than that with insulin resistance. | 24906975 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin requirement varies between patients with diabetes due to insulin resistance. | 24907169 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Age, sex,diabetes,hypertension, smoking, dyslipidemia and physical activity showed no correlation with lesion in right or circumflex coronary artery. | 24907949 |
| Blood Glucose | Deregulated Nutrient Sensing | Magnesium supplements modestly improved fasting glycemia without effect on insulin resistance. | 24909487 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Recent studies have determined that branched-chain (BCAAs) and aromatic (AAAs) amino acids are strongly correlated with obesity and atherogenic dyslipidemia and are strong predictors of diabetes. | 24910999 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | It has been established that insulin resistance is frequently associated with endothelial dysfunction. | 24911636 |
| Acanthosis Nigricans, Muscle Cramp, Hypertrophy | Deregulated Nutrient Sensing | Syndrome of insulin resistance with acanthosis nigricans, acral hypertrophy and muscle cramps in an adolescent - a rare diagnosis revisited. | 24912440 |
| Muscle Cramp, Hypertrophy | Deregulated Nutrient Sensing | The authors report a 14-y-old boy with insulin resistance, acanthosis nigricans, acral hypertrophy and muscle cramps. | 24912440 |
| Heart failure | Deregulated Nutrient Sensing | The AMPK-Nampt-Sirt1 axis also showed inhibition in advanced heart failure in addition to severely impaired AMPK activation. | 24913149 |
| Heart failure | Deregulated Nutrient Sensing | Downregulation of Sirt1 as aging change in advanced heart failure. | 24913149 |
| Reperfusion Injury | Deregulated Nutrient Sensing | Sirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against ischemia/reperfusion injury in murine heart. | 24913149 |
| Heart failure | Deregulated Nutrient Sensing | The role of Sirt1 in heart failure, especially in human hearts is not clear. | 24913149 |
| Heart failure | Deregulated Nutrient Sensing | The expression of Sirt1 and other (associated) downstream molecules in human cardiomyocytes from patients with advanced heart failure was examined. | 24913149 |
| Heart failure | Deregulated Nutrient Sensing | Sirt1 was down-regulated (54.92% +- 7.80% in advanced heart failure samples compared with healthy control cardiomyocytes). | 24913149 |
| Heart failure | Deregulated Nutrient Sensing | In advanced heart failure, low Sirt1 expression, like aging change may be a significant contributing factor in the downregulation of antioxidants and upregulation of proapoptotic molecules through the p53, FoxO1, and oxidative stress pathways. | 24913149 |
| Post-Traumatic Stress Disorder, Dyslipidemias | Deregulated Nutrient Sensing | Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia. | 24913341 |
| Post-Traumatic Stress Disorder, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Posttraumatic stress disorder (PTSD) has been linked to dyslipidemia, which is a major risk factor for coronary artery disease. | 24913341 |
| Post-Traumatic Stress Disorder, Dyslipidemias | Deregulated Nutrient Sensing | Although this link is thought to reflect response to heightened stress, behavioral health risks, including smoking, alcohol dependence, and poor sleep quality, may mediate the relationship between PTSD and dyslipidemia. | 24913341 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In fact, metformin may improve insulin resistance, a common finding of PCOS, and reduce insulin blood levels. | 24913417 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | In the presence of obesity and glucose intolerance states, particularly if those patients fail to modify their lifestyles, metformin may have some significant benefits. | 24913417 |
| Hyperglycemia, Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | At high altitude, increased gGT levels were associated with hyperglycemia; increased uric acid levels were associated with overweight/obesity, hemoglobin, dyslipidemia, high blood pressure and kidney disease. | 24914715 |
| Primary malignant neoplasm, Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Because endometrial cancer is associated with insulin resistance, the authors investigated whether a diabetes-therapeutic metformin dose inhibits cancer cell growth in patients with endometrial cancer. | 24917306 |
| Drowning | Deregulated Nutrient Sensing | GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. | 24917578 |
| Inflammation, Sleep Apnea, Obstructive, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and obstructive sleep apnea tend to coexist and are associated with inflammation, insulin resistance, dyslipidemia, and high blood pressure, but their causal relation to these abnormalities is unclear. | 24918371 |
| Weight decreased | Deregulated Nutrient Sensing | In secondary analyses, weight loss provided an incremental reduction in insulin resistance and serum triglyceride levels when combined with CPAP. | 24918371 |
| Burn injury | Deregulated Nutrient Sensing | Predictors of insulin resistance in pediatric burn injury survivors 24 to 36 months postburn. | 24918945 |
| Burn injury | Deregulated Nutrient Sensing | The purpose of this study was to identify factors associated with long-term insulin resistance in pediatric burn injury survivors. | 24918945 |
| Burn injury | Deregulated Nutrient Sensing | Burn size, time postburn, age, lean mass, and adiposity are significant predictors of insulin resistance in pediatric burn injury survivors. | 24918945 |
| ARCN1 gene, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The most prevalent co-morbidities among respondents with COPD were hypertension (54.5%) and dyslipidaemia (26.5%). | 24921714 |
| ARCN1 gene, Dyslipidemias, EQ-5D-5L - Anxiety or Depression, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Our analysis showed that the most prevalent co-morbidities in COPD were hypertension, dyslipidaemia, chronic renal disease and anxiety/depression. | 24921714 |
| CD55 gene, Obesity, Abdominal, Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | After adjusting for potential confounders, we found that greater consumption of soy protein (6.1 vs. 0.5 g/d) was inverse associated with the presence of elevated total cholesterol (TC), dyslipidemia, abdominal obesity and hyperuricemia in women, and with abdominal obesity in men, although no significant sex-soy interactions were observed (P: 0.145-0.985). | 24925121 |
| Dyslipidemias, Hyperuricemia | Deregulated Nutrient Sensing | Greater soy consumption was associated with a lower presence of elevated TC, dyslipidemia, hyperuricemia and less number of cardiometabolic disturbances components in women. | 24925121 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease. | 24927647 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (o-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). | 24927647 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Serum phospholipid o-3 PUFA levels were significantly decreased in patients with T2DM and NAFLD, and were negatively related with insulin resistance. | 24927647 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The models were adjusted for age, sex, waist circumference, diabetes mellitus, dyslipidemia, anti-inflammatory medication and month of blood sampling. | 24928661 |
| Cardiomyopathies, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In this study, we determined the respective effects of obesity, insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial function of the human myocardium before the onset of cardiomyopathy. | 24928681 |
| Obesity, Diabetes Mellitus, diabetic, Erectile dysfunction | Deregulated Nutrient Sensing | Worsening of intrinsic myocardial contraction in the transition from obesity to diabetes mellitus is likely related to worsening of cardiac mitochondrial function because impaired mitochondrial function and dynamics and contractile dysfunction are observed in diabetic patients but not in "metabolically healthy" obese patients at early stage in insulin resistance. | 24928681 |
| Obesity | Deregulated Nutrient Sensing | Zinc-Alpha 2-Glycoprotein (ZAG) has recently been implicated in the regulation of adipose tissue metabolism due to its negative association with obesity and insulin resistance. | 24929893 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prevalence of atherogenic dyslipidemia in primary care patients at moderate-very high risk of cardiovascular disease. | 24931442 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is an important risk factor for cardiovascular disease. | 24931442 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients had previous cardiovascular disease, diabetes mellitus, SCORE risk >= 3, severe hypertension or dyslipidemia. | 24931442 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia was defined as low HDL-C (<40 mg/dL [males], <50 mg/dL [females]) and elevated triglycerides (>= 150 mg/dL). | 24931442 |
| Dyslipidemias | Deregulated Nutrient Sensing | The overall atherogenic dyslipidemia prevalence was 27.1% (34.1% in diabetics). | 24931442 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | When LDL-C levels are controlled, atherogenic dyslipidemia is more prevalent in those patients at highest cardiovascular risk and with diabetes. | 24931442 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Alzheimer's disease (AD) is associated with insulin resistance and specific regional declines in cerebral metabolism. | 24931567 |
| Dyslipidemias, Obesity, Prehypertension | Deregulated Nutrient Sensing | There was a difference in baPWV and cfPWV by age group on prehypertension, dyslipidemia, current smoking, or obesity (P<0.001). | 24932081 |
| Dyslipidemias | Deregulated Nutrient Sensing | Rapid relief of dyslipidemia by LDL-A may provide early remission in about half of the NS patients who are resistant to conventional medication. | 24934117 |
| Hyperglycemia | Deregulated Nutrient Sensing | Asian patients experienced a higher incidence of grade >= 2 hyperglycemia (37.5 vs. 18.1%, p = 0.03), and greater increases in FPG, HgbA1c, and insulin resistance. | 24934865 |
| Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, hafnium, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | These patients were significantly older, with higher rates of hypertension, diabetes, clinical CAD, HF, chronic kidney disease, and cancer, and with lower rates of smoking and dyslipidemia than their counterparts (p < .05 for all). | 24935912 |
| Cancer-related fatigue, Inflammation, Low muscle mass, Obesity, Visceral | Deregulated Nutrient Sensing | Previous studies have shown that low cardiorespiratory fitness (CRF), visceral obesity and low muscle mass may share pathophysiological mechanisms, such as insulin resistance and chronic inflammation. | 24937121 |
| Diabetes Mellitus, Non-Insulin-Dependent, Chronic disease | Deregulated Nutrient Sensing | Type 2 diabetes is a chronic disease characterized by inadequate b-cell response to the progressive insulin resistance. | 24937531 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Women were significantly less likely to have their lipid profiles taken (OR=1.17, 95% CI 1.03-1.33), be prescribed lipid lowering medication for dyslipidemia (OR=1.54, 95% CI 1.20-1.97), and to be prescribed ASA following stroke (OR=1.56, 95% CI 1.39-1.75). | 24938405 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Twenty-one patients (39%) presented with hypertension, 17 (31%) with dyslipidemia, and 4 (7%) with diabetes. | 24938637 |
| Familial juvenile gout, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Kidney function progressively deteriorates in patients with familial juvenile hyperuricemiac nephropathy (FJHN, OMIN 162000) and chronic renal disease is commonly associated to dyslipidemia. | 24940667 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Body mass index, type 2 diabetes, hypertension, dyslipidemia, and obesity were compared. | 24943389 |
| Neoplasm Metastasis, Malignant Neoplasms, Neoplasms | Deregulated Nutrient Sensing | Novel (nua) kinase family 1 (NUAK1) is a member of the human adenosine monophosphate-activated protein kinases family, which is overexpressed in multiple human malignancies and thought to be involved in tumor invasion and metastasis ability. | 24943992 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Positive effects of football on fitness, lipid profile, and insulin resistance in Brazilian patients with type 2 diabetes. | 24944132 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We evaluated the effects of recreational football training combined with calorie-restricted diet (football + diet) vs calorie-restricted diet alone (diet) on aerobic fitness, lipid profile, and insulin resistance indicators in type 2 diabetes (T2D) patients. | 24944132 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. | 24947364 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. | 24947364 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | While the secretion score had a stronger association with T2D in leaner individuals (Pinteraction = 0.001), we saw no difference in the association of the insulin resistance score with T2D among BMI or waist strata (Pinteraction > 0.31). | 24947364 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | In observational studies, low serum 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and other risk factors for cardiovascular disease. | 24947792 |
| Inflammation, Dyslipidemias, Osteoporosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | The presence of common risk factors suggests that there is a relationship between osteoporosis and cardiovascular disease, possibly via dyslipidemia and inflammation. | 24949440 |
| Bone Density | Deregulated Nutrient Sensing | Sirtuin1 (Sirt1), a player in aging and metabolism, regulates bone mass and inhibits sost expression by deacetylating histone 3 at its promoter. | 24949665 |
| Dyslipidemias, Loss of facial adipose tissue | Deregulated Nutrient Sensing | To determine the effect of exercise on chemerin in relation to changes in fat loss, insulin action, and dyslipidemia in older adults. | 24950152 |
| Post-Traumatic Stress Disorder, Diabetes Mellitus | Deregulated Nutrient Sensing | Growing evidence has linked posttraumatic stress disorder (PTSD) to insulin resistance and type-2 diabetes, but most previous studies were cross-sectional. | 24950602 |
| Post-Traumatic Stress Disorder, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, PTSD was prospectively associated with a 40% increased risk of new-onset type-2 diabetes which was partially explained by a cluster of metabolic and behavioral risk factors known to influence insulin resistance. | 24950602 |
| Post-Traumatic Stress Disorder | Deregulated Nutrient Sensing | Shared biological or behavioral precursors which occur within families may lead to both PTSD and insulin resistance/diabetes. | 24950602 |
| Hyperglycemia, Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Antiretroviral treatment associated hyperglycemia and dyslipidemia among HIV infected patients at Burayu Health Center, Addis Ababa, Ethiopia: a cross-sectional comparative study. | 24950924 |
| Dyslipidemias, Overweight, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | A high prevalence of overweight, obesity, diabetes and dyslipidemia has been reported following liver transplantation (LT). | 24951998 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. | 24954334 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | These mixed dyslipidaemia combinations combination with the other risk factors such as arterial hypertension, high fasting glucose level increased all-cause and CVD mortality risk in men and women; while, these mixed dyslipidaemias plus smoking increased all-cause and CVD mortality risk only in men compared to never smokers without these dyslipidaemias (respectively HR = 1.89; HR = 1.92); and these dyslipidaemias plus obesity increased all-cause and CVD mortality risk in women (respectively HR = 2.25; HR = 2.39) and CVD mortality risk in men (HR = 1.72), as compared to responders without obesity and these dyslipidaemias. | 24955583 |
| Dyslipidemias | Deregulated Nutrient Sensing | Findings in our longitudinal study showed that in men and women mixed dyslipidaemias (HDL cholesterol <1.03 mmol/L plus triglycerides >=1.70 mmol/L) significantly increased the risk for all-cause and CVD mortality (respectively in men HR = 1.30; HR = 1.15, in women HR = 1.83; HR = 2.13). | 24955583 |
| Obesity | Deregulated Nutrient Sensing | The 12/15-lipoxygenase pathway (ALOX) is present in adipose tissue (AT) and leads to inflammatory cascades that are causal for the onset of insulin resistance in rodent models of obesity. | 24955608 |
| Obesity | Deregulated Nutrient Sensing | We have previously shown that early weaning in rats increases the risk of obesity and insulin resistance at adulthood, and leptin resistance can be a prime factor leading to these changes. | 24956416 |
| Obesity, Visceral, Hyperglycemia, Hyperphagia, Hyperleucinemia, Hypoadiponectinemia | Deregulated Nutrient Sensing | Resveratrol prevented the higher body weight, hyperphagia, visceral obesity, hyperleptinemia, hyperglycemia, insulin resistance, and hypoadiponectinemia at adulthood in animals that were early weaned. | 24956416 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Abstract Background: Lipoprotein particle sizes and concentrations are characteristically altered in patients with insulin resistance (IR) or type 2 diabetes mellitus (T2DM). | 24959989 |
| Acne | Deregulated Nutrient Sensing | Insulin resistance in patients with post-adolescent acne. | 24961925 |
| Acne | Deregulated Nutrient Sensing | We hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne. | 24961925 |
| Acne | Deregulated Nutrient Sensing | This study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne. | 24961925 |
| Ancriviroc, Fibrosis Assessment, Malnutrition | Deregulated Nutrient Sensing | Malnutrition in the advanced fibrosis stage of chronic hepatitis C (CH-C) impairs interferon (IFN) signaling by inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling. | 24962339 |
| Nonalcoholic Steatohepatitis, Lipolysis | Deregulated Nutrient Sensing | Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis. | 24962805 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Systemic insulin resistance (IR) is a primary feature in non-alcoholic steatohepatitis (NASH), however, there remain limited data on tissue-specific insulin sensitivity in vivo. | 24962805 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Of these, 72.3% self-reported having hypertension; 38.4%, dyslipidemia; and 37.8%, diabetes. | 24964639 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus is characterized by metabolic dysregulation in the form of hyperglycemia and insulin resistance and can have a profound impact on brain structure and vasculature. | 24967157 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Racial differences in the association of insulin resistance with stroke risk: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. | 24968932 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance is associated with increased stroke risk, but the effect has not been adequately examined separately in white and black populations. | 24968932 |
| COL4A2 wt Allele | Deregulated Nutrient Sensing | After adjustment for demographic factors and risk factors, there was a significant difference by race in the association of insulin resistance with risk of ICH (P=0.07), with a decrease in the risk of ICH in whites (HRln(IR)=0.61; 95% CI, 0.35-1.04) but a nonsignificant increase in blacks (HRln(IR)=1.20; 95% CI, 0.60-2.39). | 24968932 |
| COL4A2 wt Allele, Cerebrovascular accident | Deregulated Nutrient Sensing | These data support the growing evidence that insulin resistance may play a more important role in stroke risk among white than black individuals and suggest a potentially discordant relationship of insulin resistance on CI and ICH among whites. | 24968932 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance, increased risk of type II diabetes, and cardiovascular pathology. | 24968966 |
| vinyltriethoxysilane, Osteopenia | Deregulated Nutrient Sensing | GTx-758 reduced estrogen deficiency side effects of hot flashes, bone loss, and insulin resistance but with a higher incidence of VTEs. | 24968970 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent, Blood Glucose | Deregulated Nutrient Sensing | The proinflammatory cytokine interleukin (IL)-1b is implicated in the development of insulin resistance and b-cell dysfunction, whereas higher circulating levels of IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor of IL-1b, has been suggested to improve glycemia and b-cell function in patients with type 2 diabetes. | 24969107 |
| Peripheral Vascular Diseases, Inflammation, Albuminuria, Peripheral Neuropathy | Deregulated Nutrient Sensing | All underwent 24-hour blood pressure and HR monitoring, and were assessed for markers of inflammation, insulin resistance, albuminuria, presence of peripheral neuropathy and peripheral vascular disease. | 24969141 |
| Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | DEPTOR expression negatively correlates with mTORC1 activity and tumor progression in colorectal cancer. | 24969890 |
| Neoplasm Metastasis, Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | The aim of this study was to investigate the expression of DEPTOR and mTORC1 activity (P-S6) in a subset of CRC patients and determine their relation to tumor differentiation, invasion, nodal metastasis and disease-free survival. | 24969890 |
| Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Thus, we conclude that expression of DEPTOR negatively correlates with mTORC1 activity and tumor progression in CRC. | 24969890 |
| Inflammation, GRN wt Allele | Deregulated Nutrient Sensing | Collectively, our findings suggest that circulating PGRN is significantly associated with systemic insulin sensitivity and autophagic activity in adipose tissue and support the notion that PGRN functions as a potential link between chronic inflammation and insulin resistance. | 24971611 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is mainly defined by hyperandrogenism but is also characterized by insulin resistance (IR). | 24971613 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Chronic | Deregulated Nutrient Sensing | Insulin resistance (IR) affects sustained virological response (SVR) to peginterferon alfa plus ribavirin (PR) in patients with chronic hepatitis C (CHC). | 24974131 |
| Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent, Beta-cell dysfunction | Deregulated Nutrient Sensing | Diabetes appeared associated with classical risk factors for type 2 diabetes (i.e., age, sex, family history of diabetes and body mass index), and both beta-cell dysfunction and insulin resistance appeared relevant determinants. | 24974302 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | After adjustment for age, ethnicity, education, smoking, alcohol consumption, dyslipidaemia and BMI, increases in android fat percentage were significantly associated with total cholesterol, TG and HDL cholesterol in males, and total cholesterol, HDL cholesterol and LDL cholesterol in females. | 24974911 |
| Dyslipidemias | Deregulated Nutrient Sensing | Further research should consider sex differences and dyslipidemia. | 24975752 |
| glucose tolerance | Deregulated Nutrient Sensing | The development of glucose tolerance disorders in adults involves insulin resistance and impaired insulin secretion. | 24979613 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | These 105 patients were older and had a higher body mass index, a larger waist circumference, higher fasting blood glucose and triglyceride concentrations and lower low-density lipoprotein cholesterol concentrations than non-diabetic patients; they also had higher rates of hypertension (P=0.001) and dyslipidaemia (P=0.02). | 24980776 |
| Hyperglycemia | Deregulated Nutrient Sensing | Circulating human epidermal growth factor receptor 2 (HER2) is associated with hyperglycaemia and insulin resistance. | 24981162 |
| Hyperglycemia | Deregulated Nutrient Sensing | Bivariate and multivariate linear regression analyses on the whole study population revealed that the associations between hyperglycemia and HER2, as well as between ISI and HER2, were independent of factors known to be associated with T2DM and insulin resistance (e.g. | 24981162 |
| Hyperglycemia | Deregulated Nutrient Sensing | There is an independent association between HER2 levels and hyperglycemia and insulin resistance that is not modified by country of birth. | 24981162 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. | 24981337 |
| Dyslipidemias, Diabetes Mellitus, cardiovascular problem, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | The objective is to determine the presence of peripheral arterial disease (PAD) and the factors associated in elderly patients, analyzing variables such as sex, age, smoking, diabetes, hypertension, dyslipidemia, and cardiovascular problems. | 24984302 |
| Impaired T cell function | Deregulated Nutrient Sensing | Prediabetes is an early stage of b-cell dysfunction presenting as insulin resistance. | 24985580 |
| Refractory anemias, Rheumatoid Arthritis | Deregulated Nutrient Sensing | In prior reports, individuals with rheumatoid arthritis (RA) exhibited increased insulin resistance. | 24986846 |
| Renal glomerular disease | Deregulated Nutrient Sensing | Here, we demonstrated that mammalian target of rapamycin complex 1 (mTORC1) signaling was remarkably activated and hypoxia-inducible factor (HIF) 1a expression was largely induced in cellular crescents from patients with crescentic glomerular diseases. | 24990893 |
| Abnormal renal function | Deregulated Nutrient Sensing | Specific deletion of Tsc1 in podocytes led to mTORC1 activation in podocytes and kidney dysfunction in mice. | 24990893 |
| Renal glomerular disease | Deregulated Nutrient Sensing | Together, it is concluded that mTORC1 activation in podocytes promotes cellular crescent formation, and targeting this signaling may shed new light on the treatment of patients with crescentic glomerular diseases. | 24990893 |
| Chronic Obstructive Airway Disease, Dyslipidemias, Carcinoma of lung, Cerebrovascular accident | Deregulated Nutrient Sensing | Age, male sex, and chronic obstructive pulmonary disease were positively; but dyslipidemia, stroke and higher socioeconomic status were negatively associated with lung cancer. | 24991802 |
| Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Type 2 diabetes is often accompanied by altered cardiometabolic risk profiles, including abdominal obesity, hypertension, and dyslipidaemia. | 24992024 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Ageing and type 2 diabetes in an elderly Chinese population: the role of insulin resistance and beta cell dysfunction. | 24992623 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Individuals with NGT or prediabetes who progressed to T2D during follow-up had a significantly increased insulin resistance and a decreased beta cell function (p < 0.01). | 24992623 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | In contrast, individuals who regressed from prediabetes to NGT increased both insulin resistance and beta cell function (p < 0.01). | 24992623 |
| Microalbuminuria, Inflammation | Deregulated Nutrient Sensing | Association of urinary RBP4 with insulin resistance, inflammation, and microalbuminuria. | 24994759 |
| Microalbuminuria, Inflammation | Deregulated Nutrient Sensing | Urinary RBP4 concentrations were elevated in patients with dysregulation of glucose metabolism and were related to various cardiometabolic risk factors including insulin resistance, inflammation, and microalbuminuria. | 24994759 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Comparison of the efficacy and safety profile of morning administration of controlled-release simvastatin versus evening administration of immediate-release simvastatin in chronic kidney disease patients with dyslipidemia. | 24996489 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Morning administration of CR simvastatin is expected to increase patient compliance and therefore better control of dyslipidemia in CKD patients. | 24996489 |
| Obesity | Deregulated Nutrient Sensing | Decreased omentin-1 levels may contribute to the development of insulin resistance, T2DM and particularly to obesity in Chinese adults, however, its role in these diseases needs to be fully elucidated. | 24997770 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. | 24998955 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The high percentage of obesity, hypertension and dyslipidaemia among them are important co morbidity factors which if not controlled can cause further increase in the number of chronic complications. | 24999139 |
| Metabolic Diseases, Primary malignant neoplasm | Deregulated Nutrient Sensing | Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders. | 25000096 |
| Primary malignant neoplasm, Diabetes Mellitus, Non-Insulin-Dependent, Disease, Obesity | Deregulated Nutrient Sensing | Sirtuin 1(SIRT1), a NAD(+) dependent class III histone deacetylase is involved in a variety of human disorders such as obesity, type II diabetes, cancer and aging. | 25000096 |
| Metabolic Diseases, Primary malignant neoplasm | Deregulated Nutrient Sensing | Inhibition of SIRT1 could be useful for cancer treatment while activators can be useful for longevity and treating metabolic disorders. | 25000096 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | In this paper, we report diverse small molecule inhibitors with a potential to attenuate cancer growth designed based on high-throughput virtual screening and docking using the crystal structure of SIRT1. | 25000096 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Recent animal studies indicated that VEGF-B signaling had determinant roles in insulin resistance, lipid distribution and metabolism in type 2 diabetes. | 25001655 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This mechanism can contribute to the development of insulin resistance and diabetes associated with immunosuppressive therapy. | 25004245 |
| Refractory anemias, Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Our aim was to describe the prevalence of dyslipidaemia, serum lipid behaviour and predictors of serum lipid levels in a cohort of early rheumatoid arthritis (RA) patients. | 25005131 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidaemia in early RA patients differed from the matched controls. | 25005131 |
| Glucose Intolerance (disease), Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | In these enrolled subjects, 88% have glucose intolerance status (pre-diabetes or diabetes). | 25007953 |
| Glucose Intolerance (disease), Memory impairment | Deregulated Nutrient Sensing | High-fat diet enhanced glucose intolerance, brain soluble Ab, and memory impairment in 3xTg-AD mice. | 25008180 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Partly replacing meat protein with soy protein alters insulin resistance and blood lipids in postmenopausal women with abdominal obesity. | 25008579 |
| Hypertriglyceridemia, Dyslipidemias, Obesity, Acanthosis Nigricans, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence rates of hypertension, dyslipidemia, hypertriglyceridemia, and acanthosis nigricans in severe obese children were higher than those in moderate obesity. | 25009022 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients suffering from type 2 diabetes mellitus (T2DM) often exhibit chronic elevated lactate levels which can promote peripheral insulin resistance by disturbing skeletal muscle insulin-signaling. | 25009968 |
| glycation, Prediabetes syndrome | Deregulated Nutrient Sensing | Effect of dietary prebiotic supplementation on advanced glycation, insulin resistance and inflammatory biomarkers in adults with pre-diabetes: a study protocol for a double-blind placebo-controlled randomised crossover clinical trial. | 25011647 |
| Inflammation | Deregulated Nutrient Sensing | AGEs are thought to stimulate chronic low-grade inflammation and promote oxidative stress and have been linked to the development of insulin resistance. | 25011647 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Simple therapeutic strategies targeted at attenuating the progression of chronic low-grade inflammation and insulin resistance are urgently required to prevent or slow the development of type 2 diabetes in susceptible individuals. | 25011647 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of large subcutaneous adipocytes in obesity has been proposed to be linked with insulin resistance and type 2 diabetes through the "adipose tissue expandability" hypothesis, which holds that large adipocytes have a limited capacity for expansion, forcing lipids to be stored in nonadipose ectopic depots (skeletal muscle, liver), where they interfere with insulin signaling. | 25011943 |
| Alarmins, diabetic | Deregulated Nutrient Sensing | Accumulation of damp heat in spleen type accounts for the highest proportion in type 2 diabetic patients, and there exists serious insulin resistance. | 25016266 |
| Chronic Kidney Diseases, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Arterial location-specific calcification at the carotid artery and aortic arch for chronic kidney disease, diabetes mellitus, hypertension, and dyslipidemia. | 25017195 |
| Chronic Kidney Diseases, Dyslipidemias, Demographics Domain, Hypertension, CTCAE | Deregulated Nutrient Sensing | The multivariate analyses were adjusted for age, gender, CKD, DM, hypertension, dyslipidemia, and current smoking status. | 25017195 |
| Dyslipidemias, Calcinosis | Deregulated Nutrient Sensing | Dyslipidemia did not have any significant association with calcification in any of the three vascular beds. | 25017195 |
| Metabolic Diseases | Deregulated Nutrient Sensing | The results confirmed that insulin resistance is present in many obese children and adolescents, and that this condition is associated with alterations that represent an increased risk for developing metabolic disorders in adulthood. | 25019650 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer. | 25024613 |
| Weight Gain | Deregulated Nutrient Sensing | In adults, insulin resistance may decrease the thermogenic effect of food, contributing to weight gain. | 25026915 |
| Obesity | Deregulated Nutrient Sensing | We aimed to determine the effect of insulin resistance on energy expenditure in children with long-standing obesity. | 25026915 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | 20% of patients with hypertension, 41% with dyslipidemia and 36% with diabetes mellitus were in control at baseline. | 25027581 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Over 12 months, therapy of 61% of patients with baseline poor control was modified for hypertension, 33% for dyslipidemia, and 85% for diabetes mellitus. | 25027581 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We found low rates of potential overtreatment with 2% for hypertension, 3% for diabetes mellitus and 3-6% for dyslipidemia. | 25027581 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | DPP4 activity is an important predictor of the onset of insulin resistance, prediabetes, and type 2 diabetes in apparently healthy Chinese individuals. | 25029421 |
| Cardiac Arrest, Hyperglycemia, Hypothermia due to exposure | Deregulated Nutrient Sensing | Hyperglycemia and insulin resistance in cardiac arrest patients treated with moderate hypothermia. | 25033067 |
| Hypothermia due to exposure | Deregulated Nutrient Sensing | BG, insulin infusion rates, and insulin resistance during hypothermia, during rewarming, and 24-48 hours after hypothermia were not significantly different between the 2 groups. | 25033067 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. | 25034241 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose (FPG) levels are not clear. | 25034241 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio. | 25034241 |
| Hypertension, CTCAE, Dyslipidemias, Respiration Disorders | Deregulated Nutrient Sensing | The most frequent co-morbidities were: hypertension (30.0%), dyslipidemia (23.3%) and respiratory disease (25.2%). | 25034320 |
| Obesity, Abdominal, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Central arterial stiffness and diastolic dysfunction are associated with insulin resistance and abdominal obesity in young women but polycystic ovary syndrome does not confer additional risk. | 25035436 |
| Prostate Cancer Outcomes Study, Cardiovascular Physiological Phenomena, Obesity | Deregulated Nutrient Sensing | Insulin resistance and central obesity are associated with subclinical cardiovascular dysfunction in young women, but a diagnosis of PCOS does not appear to confer additional risk at this age. | 25035436 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | However, it is difficult to establish how much of this risk is due to PCOS per se and how much is due to obesity and insulin resistance, which are common in PCOS and themselves associated with greater vascular risk. | 25035436 |
| Arterial Stiffness, Prostate Cancer Outcomes Study, Diastolic dysfunction, Obesity | Deregulated Nutrient Sensing | This study shows that central arterial stiffness and diastolic dysfunction are not increased in young women with PCOS, whereas they are associated with both insulin resistance and central obesity. | 25035436 |
| Neoplasm Metastasis, Neoplasms | Deregulated Nutrient Sensing | In this study, we report the impact of the investigational drug PP242, a potent and selective small-molecule active-site TORC1/2 kinase inhibitor, on tumor growth and metastasis. | 25035961 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This observed dysregulation in energy-related metabolism may be the underlying factor leading to the molecular mechanisms responsible for the insulin resistance of patients with T2D. | 25036354 |
| atherosclerotic | Deregulated Nutrient Sensing | In this study, we observed an inverse correlation between SIRT1, a class III histone deacetylase, and PAI-1 expression in human atherosclerotic plaques and the aortas of old mice, suggesting that internal negative regulation exists between SIRT1 and PAI-1. | 25040736 |
| Arterial Stiffness | Deregulated Nutrient Sensing | SIRT1 overexpression reversed the increased PAI-1 expression in senescent human umbilical vein endothelial cells (HUVECs) and aortas of old mice, accompanied by decreased SA-b-gal activity in vitro and improved endothelial function and reduced arterial stiffness in vivo. | 25040736 |
| Old age | Deregulated Nutrient Sensing | Moreover, the SIRT1-mediated inhibition of PAI-1 expression exerted an antisenescence effect in HUVECs. | 25040736 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Amino acid (AA) metabolism is altered in type 2 diabetes (T2D), and fasting levels of a-hydroxybutyrate (a-HB), a biomarker for insulin resistance, have been suggested to track AA metabolism. | 25040945 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Compared to N-pre group, the pre-group had a significantly higher rate of smoking [56.4% (79/140) vs. 44.4% (92/207), P < 0.05], dyslipidemia [61.4% (86/140) vs. 50.2% (104/207), P < 0.05] and positive family history of coronary artery disease [39.3% (55/140) vs. 24.6% (51/207), P < 0.01]. | 25042917 |
| Coronary Stenosis, Dyslipidemias, Smoking, Immature, Coronary Artery Disease, Heart failure | Deregulated Nutrient Sensing | Smoking, dyslipidemia and family history of coronary artery disease are major risk factors for patients with premature ACS, these patients are more likely to have milder coronary artery stenosis and a lower incidence of heart failure compared to N-pre group. | 25042917 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Insulin resistance (IR) increases Alzheimer's disease (AD) risk. | 25043908 |
| Hyperglycemia | Deregulated Nutrient Sensing | In participants with normoglycemia but not hyperglycemia, higher insulin resistance corresponded to higher PiB uptake in frontal and temporal areas, reflecting increased amyloid deposition. | 25043908 |
| Data types - Address | Deregulated Nutrient Sensing | This is the first human study to demonstrate that insulin resistance may contribute to amyloid deposition in brain regions affected by AD. | 25043908 |
| HD Term Type, Cardiac complication, Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia accelerates the development of cardiovascular complications and contributes to mortality of hemodialysis (HD) patients. | 25044013 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | Lifestyle changes have selective efficacy in the treatment of dyslipidemia in HD patients, while atorvastatin (up to 20 mg/d) may be effective in about 60% of nonresponders to lifestyle changes. | 25044013 |
| Heat-Shock Response | Deregulated Nutrient Sensing | Recent studies suggest that diethylhexyl phthalates (DEHP) could contribute to the development of insulin resistance (IR) through oxidative stress, and that heat shock protein (HSP) could be related with the association between DEHP and IR. | 25044062 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Improvement in vitamin D status does not improve insulin resistance, blood pressure, inflammation or HbA1c, but might increase insulin secretion in patients with established type 2 diabetes. | 25044176 |
| Microalbuminuria, Arterial Stiffness, Endothelial dysfunction | Deregulated Nutrient Sensing | Microalbuminuria is a marker of generalized endothelial dysfunction resulting from arterial stiffness or insulin resistance, and brachial-ankle pulse wave velocity (baPWV) is a good measure of arterial stiffness. | 25045226 |
| Microalbuminuria | Deregulated Nutrient Sensing | Elevated baPWV was independently associated with microalbuminuria regardless of insulin resistance among rural subjects over 40 yr. | 25045226 |
| Impaired T cell function, Obesity | Deregulated Nutrient Sensing | Plasma free fatty acids do not provide the link between obesity and insulin resistance or b-cell dysfunction: results of the Reading, Imperial, Surrey, Cambridge, Kings (RISCK) study. | 25047698 |
| Impaired T cell function | Deregulated Nutrient Sensing | It is unlikely that plasma free fatty acids are the primary mediators of obesity-related insulin resistance or b-cell dysfunction. | 25047698 |
| Degenerative polyarthritis, Cartilage damage | Deregulated Nutrient Sensing | PGC-1a and FoxO3A limit oxidative stress and at least partially mediate the capacity of AMPK activity to block procatabolic responses in chondrocytes, and therefore have the potential to inhibit the progression of cartilage damage in OA. | 25047750 |
| Thrombosis, Prediabetes syndrome | Deregulated Nutrient Sensing | In pre-diabetes disorders in which pathogenesis the insulin resistance (IR) plays a leading role, the risk of thrombosis due to increased coagulation factors, decreased concentration of physiological anticoagulants and inhibition of fibrinolysis is increased. | 25051771 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patient vascular risk factors included smoking, dyslipidemia, and hypertension. | 25051964 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased serum uric acid (SUA) is associated with dyslipidemia. | 25052552 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome. | 25053727 |
| Atherosclerosis | Deregulated Nutrient Sensing | To investigate the role of increased intrahepatic fat in the association of SCH with insulin resistance, MS, and coronary atherosclerosis. | 25053728 |
| SLC25A20 gene | Deregulated Nutrient Sensing | SCH with FL is associated with increased odds of MS, insulin resistance, and CAC, independent of potential confounders. | 25053728 |
| Inflammation, Breast Carcinoma | Deregulated Nutrient Sensing | Insulin resistance and inflammation may mediate the effects of central adiposity on mortality among breast cancer patients. | 25056184 |
| Napping, Diabetes Mellitus | Deregulated Nutrient Sensing | Association of napping and night-time sleep with impaired glucose regulation, insulin resistance and glycated haemoglobin in Chinese middle-aged adults with no diabetes: a cross-sectional study. | 25056969 |
| Dyslipidemias | Deregulated Nutrient Sensing | Studies have indicated that patients may experience persistent dyslipidemia despite chronic statin treatment. | 25060204 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Patient characteristics and lipid measurements were used to determine variables contributing to dyslipidemia (abnormal low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], or total triglyceride [TG] values). | 25060204 |
| Impaired cognition | Deregulated Nutrient Sensing | The relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment. | 25060738 |
| Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. | 25060738 |
| Diabetic Nephropathy, Ischemic stroke, Metabolic Syndrome X, Diabetes Mellitus | Deregulated Nutrient Sensing | Independent risk factors for ischemic stroke were duration of diabetes mellitus, presence of diabetic nephropathy, higher hemoglobin A1c, higher systolic blood pressure, insulin resistance, and history of smoking, whereas sex, lipids, high-sensitivity C-reactive protein, and the metabolic syndrome were not associated with an increased risk. | 25061078 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients in the CAD group were significantly older (41.59 +- 3.79 versus 39.27 +- 4.97 years; P-value < 0.01), and had higher rates of diabetes mellitus (P-value = 0.04) and dyslipidemia (P-value = 0.01). | 25065277 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Our findings suggest that Japanese population with higher insulin and C-peptide levels derived from insulin resistance have an elevated risk of gastric cancer. | 25066446 |
| Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | History of dyslipidemia had in 73.3% of patients, 27.8% had cardiovascular disease and 82.7% had hypertension. | 25066820 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Prevention of this complication with active therapy for risk factors, such as hypertension and dyslipidemia is warranted. | 25066820 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Vitamin D deficiency is a common condition that is associated with diabetes and insulin resistance. | 25072652 |
| ARCN1 gene, Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus, Asthma, Hypertension, CTCAE | Deregulated Nutrient Sensing | Prevalence: dyslipidemias (34.8); arterial hypertension (17.8); Diabetes (5.3); asthma (4.6); COPD (2.2); ischaemic heart disease (1.8) and (1.5) cardio-circulatory pathologies. | 25072788 |
| Diabetes Mellitus, Bipolar Disorder | Deregulated Nutrient Sensing | Insulin resistance, diabetes mellitus, and brain structure in bipolar disorders. | 25074491 |
| Albuminuria, Dyslipidemias, Obesity, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hypertension was frequent in all CKD stages (80%-94%), whereas there was a lower prevalence of dyslipidemia, albuminuria, and obesity associated with more advanced CKD. | 25074838 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia in chronic kidney disease: randomized controlled trial of colestilan versus simvastatin in dialysis patients. | 25079861 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with the new generation of antipsychotic drugs compared to conventional therapy. | 25082252 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | To investigate the incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with antipsychotics of new generation compared to conventional therapy. | 25082252 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia in the form of hypertriglyceridemia occurs more frequently in patients on therapy with the new generation of antipsychotics compared to patients treated with conventional therapy. | 25082252 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Hypercholesterolemia as a form of dyslipidemia had not been proven as significantly frequent during the therapy with new antipsychotics in relation to classical antipsychotic treatment. | 25082252 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The clinical manifestations and the sequelae of PCOS vary throughout the lifecycle, partly depending on environmental factors which may affect the integral components of the syndrome, namely ovarian steroidogenesis, ovulation and insulin resistance. | 25083888 |
| Hyperlipidemia, Primary malignant neoplasm, Inflammation | Deregulated Nutrient Sensing | Since hyperlipidemia, inflammation, insulin resistance and obesity increase breast cancer risk, elevating GH may serve to exacerbate cancer progression. | 25085903 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | In China, even though the prevalence of dyslipidemia among adults increased yearly and dyslipidemia being an important risk factor for cardiovascular diseases among the Chinese population, however, the awareness, treatment and control of dyslipidemia are at low levels, and only limited studies on the influence factors associated with the awareness, treatment and control dyslipidemia in China have been carried out. | 25086650 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increase in age and BMI >= 24 kg/m2 were by far the strongest risk factors associated with better awareness and treatment of dyslipidemia. | 25086650 |
| Dyslipidemias | Deregulated Nutrient Sensing | A family history of dyslipidemia increased the likelihood of awareness (OR=3.620; 95% CI: 2.816, 4.653) and treatment (OR=3.298; 95% CI: 2.488, 4.371) of dyslipidemia. | 25086650 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Promotion of healthy lifestyles and establishment of a comprehensive strategy of screening, treatment and control of dyslipidemia is needed to reduce or prevent the risk of cardiovascular disease in the Jilin province. | 25086650 |
| Coronary Artery Disease, Ventricular Dysfunction, Left | Deregulated Nutrient Sensing | Epicardial adipose tissue and insulin resistance in patients with coronary artery disease with or without left ventricular dysfunction. | 25087293 |
| Systolic dysfunction | Deregulated Nutrient Sensing | Aim of this study was to evaluate the ability of insulin resistance to predict EAT thickness in patients with significant CAD and systolic dysfunction. | 25087293 |
| Eating, Ventricular Dysfunction, Left | Deregulated Nutrient Sensing | Potassium levels and all three indexes of insulin resistance were the best independent predictors of EAT in the study population as a whole and in the subset of patients with left ventricular dysfunction. | 25087293 |
| Ventricular Dysfunction | Deregulated Nutrient Sensing | Insulin resistance is an independent predictor of EAT thickness in patients affected by CAD, also in the presence of significant left ventricular dysfunction. | 25087293 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | The association between dyslipidemia (DL) and stroke recurrence is unclear, but may be influenced by different subtypes of stroke. | 25088494 |
| Obesity | Deregulated Nutrient Sensing | Intrahepatic fat was associated with insulin resistance independent of age, sex, and measures of obesity in Japanese adults. | 25091356 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In 73.1%, at least 1 cardiovascular risk factor was identified: smoking (40.5%), obesity (26.0%), dyslipidemia (24.8%), hypertension (24.3%), and diabetes mellitus (12.3%). | 25091923 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | After multivariate adjustment robust associations with coronary heart disease, myocardial infarction and dyslipidemia remained. | 25093413 |
| Prostate Cancer Outcomes Study, Obesity, Abdominal, Polycystic Ovary Syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | Insulin resistance associated with abdominal obesity plays a leading role in the etiology of hyperandrogenism and other clinical features of the polycystic ovary syndrome (PCOS). | 25093427 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Oppositely, fasting insulin (OR 1.03, P < 0.001), hyperglycemia (OR 1.25, P = 0.002) and dyslipidemia (OR 1.25, P = 0.002), but not hypertension, BMI and WC, significantly increased the risk of mildly reduced eGFR. | 25099525 |
| Diabetic Nephropathy, Dyslipidemias | Deregulated Nutrient Sensing | The SCH group had a higher prevalence of dyslipidemia (p = 0.008) and diabetic nephropathy (p = 0.014) than the euthyroid group. | 25100149 |
| Toxic effect | Deregulated Nutrient Sensing | Moreover, decreased insulin/IGF-1 signaling promotes the maintenance of protein quality control and suppresses the onset of cellular toxicity caused by aggregate-prone proteins. | 25102325 |
| Toxic effect | Deregulated Nutrient Sensing | Thus, partial genetic manipulation of the insulin/IGF-1 signaling pathway does not seem sufficient to counteract protein toxicity and extend animal survival. | 25102325 |
| Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology. | 25105135 |
| TNF protein, human, Inflammation, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The present studies have demonstrated an independent association of higher PP with higher TNF-a, a marker of insulin resistance, and neutrophil count in community-living elderly women and suggest that insulin resistance and chronic low-grade inflammation may in part be responsible for the association between high PP and incident type 2 diabetes found in elderly patients with hypertension. | 25105150 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | A high prevalence of obesity (59.9%), type 2 diabetes mellitus (25%), high blood pressure (47.2%), and dyslipidemia (44.4%) was found in the total sample, with no difference between the study groups. | 25106709 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Our results confirm the high prevalence of obesity, type 2 diabetes mellitus, high blood pressure, and dyslipidemia in patients with asymptomatic PHP. | 25106709 |
| Dyslipidemias | Deregulated Nutrient Sensing | To assess the influence of dyslipidemia on urinary lithogenic metabolites and stone recurrence in stone formers. | 25106943 |
| Tauopathies, Data types - Address | Deregulated Nutrient Sensing | These results provide confirmation and specificity that abnormal phosphorylation of IRS1 is a pathological feature of AD and other tauopathies, and provide support for an association between insulin resistance and abnormal tau as well as amyloid-b. | 25107476 |
| Vascular calcification, Atherosclerosis | Deregulated Nutrient Sensing | The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: the Multi-Ethnic Study of Atherosclerosis. | 25108074 |
| Obesity, Abdominal, Vascular calcification | Deregulated Nutrient Sensing | Insulin resistance may be related to vascular calcification as both are associated with abdominal obesity. | 25108074 |
| atherosclerotic | Deregulated Nutrient Sensing | Atherosclerotic calcification, especially in the coronary arteries, is related to insulin resistance. | 25108074 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In contrast, risk for established (baseline) diabetes mellitus was lower (OR=0.49, 95% Cl 0.26-0.93, p=0.03) in heterozygotes, after adjustment for atherogenic dyslipidemia and other confounders. | 25108206 |
| TG gene, Diabetes Mellitus, Non-Insulin-Dependent, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Obese T2D patients with high TG:HDL, associated with increased insulin resistance, had considerably increased risk of CHD and CVD. | 25108897 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We could not observe the increase rate of glucose intolerance in statin group. | 25109606 |
| Dyslipidemias, Metabolic Syndrome X, MS gene, Obesity | Deregulated Nutrient Sensing | Dyslipidaemia and central obesity are the major factors underlying the dramatic increase in metabolic syndrome (MS). | 25109606 |
| Prediabetes syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Early statin treatment can be an effective option in obese patients with MS, prediabetes and mild dyslipidaemia with further improvement of cardiovascular risk factors. | 25109606 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | The hypertriglyceridemia is associated with isolated impaired glucose tolerance in subjects without insulin resistance. | 25111858 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | The objective of this study was to determine if hypertriglyceridemia is associated with isolated impaired glucose tolerance in subjects without insulin resistance. | 25111858 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | Results of this study indicate that hypertriglyceridemia is independently associated with isolated impaired glucose tolerance in subjects without insulin resistance. | 25111858 |
| Dyslipidemias | Deregulated Nutrient Sensing | Amplification was marginally but significantly influenced by CVRFs, with smoking and dyslipidaemia decreasing amplification, but increased with increasing levels of blood glucose. | 25112663 |
| Arterial Stiffness, Hyperglycemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Notably, obesity is a modifiable determinant of arterial stiffness independent of high blood pressure, dyslipidemia and hyperglycemia in this population. | 25112799 |
| Increased insulin level, Hyperuricemia | Deregulated Nutrient Sensing | Insulin resistance itself or compensatory hyperinsulinemia may contribute to the development of hyperuricemia. | 25112919 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Higher body mass index and waist circumference, hypertension, dyslipidemia, and current smoking were each associated with higher prevalence of diabetes in both men and women. | 25112921 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study. | 25117473 |
| Sense of Inadequacy Scale | Deregulated Nutrient Sensing | Inadequacy was observed in 11, 9, 3 and 4% in relation to insulin resistance, fasting insulin, blood pressure and glycemia, respectively. | 25119752 |
| Steatohepatitis | Deregulated Nutrient Sensing | Hepatic steatosis was found in 20% of the patients and insulin resistance, in 29%. | 25119755 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is the primary risk factor for cardiovascular disease, and statins have been effective in controlling lipid levels. | 25120083 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipidemia and disturbed liver function. | 25120819 |
| Dyslipidemias | Deregulated Nutrient Sensing | Lipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia. | 25121984 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore, there is a need to identify novel early markers of glucose intolerance that reflect the underlying biology and the overall physiological, metabolic and clinical characteristics of progression towards diabetes. | 25125339 |
| Weight Gain, Bipolar Disorder | Deregulated Nutrient Sensing | Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. | 25130211 |
| Hyperinsulinism, Impaired T cell function | Deregulated Nutrient Sensing | Hyperinsulinaemia, insulin resistance and b-cell dysfunction were not related to the incidence of isolated impaired glucose tolerance in either gender. | 25131451 |
| Dyslipidemias, Osteopenia | Deregulated Nutrient Sensing | Our findings suggest that in elderly male patients with osteopenia and mild dyslipidemia, therapeutic doses of atorvastatin were associated with positive effects on BMD, probably mediated by suppressed bone resorption. | 25131773 |
| Weight Gain, Diabetes Mellitus, Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | With increasing obesity in childhood and adolescence, weight gain, and insulin resistance become also more frequent in patients with type 1 diabetes mellitus (T1DM). | 25131985 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The effect of insulin resistance on breast cancer risk in Latinas of Mexican origin. | 25136964 |
| Prediabetes syndrome, Breast Carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | We determined the effect of insulin resistance (IR) on breast cancer risk in Latinas of Mexican origin who did not have a direct family history of breast cancer and had not been previously diagnosed with prediabetes or diabetes. | 25136964 |
| Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are associated with an increase of cardiovascular risk factors, including adipocytokines. | 25137262 |
| Uremia | Deregulated Nutrient Sensing | Insulin resistance is commonly observed in uremic patients. | 25137874 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients. | 25139823 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | We investigated tumor expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in relation with patient survival and tumor relapse in a retrospective cohort of 460 breast cancer patients. | 25139823 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Immunohistochemical staining for LSD1, HDAC2 and SIRT1 was performed on tissue microarrays of tumor and corresponding normal formalin-fixed paraffin-embedded tissues from breast cancer patients. | 25139823 |
| Neoplasms | Deregulated Nutrient Sensing | Expression of LSD1 and SIRT1, but not of HDAC2, was significantly increased in tumor tissues compared to their normal counterparts (both p < 0.001). | 25139823 |
| Neoplasms | Deregulated Nutrient Sensing | When the combined expression levels were analyzed, high expression of LSD1, HDAC2 and SIRT1 showed shorter patient survival time and shorter time to tumor relapse and correlated with poor tumor differentiation and a high level of tumor cell proliferation. | 25139823 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | The disposition index emphasizes the importance of taking into account both skeletal muscle and hepatic insulin resistance to depict insulin secretion. | 25139885 |
| Hypertension, CTCAE, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. | 25142635 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Deregulated Nutrient Sensing | SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27. | 25143434 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | In addition, SIRT1 silencing suppresses non-small cell lung cancer (NSCLC) proliferation and induces senescence in a p27(Kip1)-dependent manner. | 25143434 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Furthermore, SIRT1 silencing dramatically suppresses tumor formation and proliferation in two distinct NSCLC xenograft mouse models. | 25143434 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Collectively, these data demonstrate that not only SIRT1 is an important regulator of p27(Kip1) but also SIRT inhibition induces senescence and antigrowth potential in lung cancer in vivo. | 25143434 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | SIRT1 is a key regulator of p27 protein levels and SIRT1 inhibition is a viable strategy for NSCLC therapy by means of p27 reactivation. | 25143434 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular disease (CVD) is related to insulin resistance (IR) and obesity, characterized by changes in plasma levels of inflammatory markers, such as adiponectin and C-reactive protein (CRP). | 25145771 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer. | 25146318 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Expression of SIRT1, a class III HDAC, is related to poor prognosis in some malignancies. | 25146318 |
| Malignant neoplasm of stomach | Deregulated Nutrient Sensing | We investigated the correlation between SIRT1 expression and progression and prognosis of gastric cancers comparing with molecules linked to SIRT1 in order to better predict the efficacy of HDAC inhibitors in treating this disease. | 25146318 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | We evaluated SIRT1 expression by western blot in 51 cases and SIRT1, DBC1, acetylated H4K16 (H4K16Ac), acetylated H3K9 (H3K9Ac), and p53 by immunohistochemistry (IHC) in 557 cases of gastric cancer. | 25146318 |
| Neoplasms, Venous Invasion | Deregulated Nutrient Sensing | Western blotting showed that SIRT1 high expression related with statistics to advanced tumor progression, positive lymphatic invasion, positive venous invasion, and advanced stage but not to poor prognosis. | 25146318 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | We found that SIRT1 high expression closely correlates with progression and prognosis in gastric cancer patients. | 25146318 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | And it was also indicated that SIRT1 acts as an oncogene by the results of DBC1, H4K16Ac, and H3K9Ac and might be a target molecule of HDAC inhibitor treatment for gastric cancer patients. | 25146318 |
| Hyperamylasemia, Obesity | Deregulated Nutrient Sensing | Amylin deposition is promoted by chronic hypersecretion of amylin (hyperamylinemia), which is common in humans with obesity or pre-diabetic insulin resistance. | 25149184 |
| Dyslipidemias, Toxic effect, Genus Erwinia | Deregulated Nutrient Sensing | The toxicity of very prolonged courses of PEGasparaginase or Erwinia asparaginase in relation to asparaginase activity, with a special focus on dyslipidemia. | 25150254 |
| Dyslipidemias, Genus Erwinia | Deregulated Nutrient Sensing | In patients receiving Erwinia asparaginase, triglyceride levels increased in the first weeks as well, but no grade 3/4 dyslipidemia was found. | 25150254 |
| Dyslipidemias, Toxic effect | Deregulated Nutrient Sensing | Dyslipidemia was the only toxicity related to levels of asparaginase activity. | 25150254 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Among middle-aged and older Japanese adults, sleep-related intermittent hypoxemia is associated with glucose intolerance and insulin resistance, and may contribute to the development of type 2 diabetes mellitus. | 25156748 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Sleep-related intermittent hypoxemia and glucose intolerance: a community-based study. | 25156748 |
| Lipodystrophy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In rare families, loss-of-function (LOF) mutations in PPARG are known to cosegregate with lipodystrophy and insulin resistance; in the general population, the common P12A variant is associated with a decreased risk of type 2 diabetes (T2D). | 25157153 |
| Dyslipidemias, Myocardial Ischemia, Congestive heart failure, Hypertensive disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | 86% suffered from hypertension (HTN), 40% were diabetics and ~ 1/3 had ischemic heart disease, congestive heart failure (CHF), and dyslipidemia. | 25161116 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and pathoglycemia were standardized to the WHO world standard population. | 25164228 |
| Dyslipidemias | Deregulated Nutrient Sensing | (1) The age adjusted mean average levels of blood lipid and glucose and the standardized prevalence rate of dyslipidemia and increased blood glucose as well as cardiovascular risk factors were significantly higher in the urban than in the rural residents and higher in male than in female participants (P < 0.01 or 0.05). | 25164228 |
| Weight decreased, Osage language, Dyslipidemias, Diabetes Mellitus, Hypertensive disease, Sleep Apnea, Obstructive, Hypertension, CTCAE | Deregulated Nutrient Sensing | Postoperative weight loss and partial or full resolution of: type 2 diabetes mellitus (T2DM), hypertension (HTN), dyslipidaemia and obstructive sleep apnoea (OSA). | 25164850 |
| Lipodystrophy, Dyslipidemias | Deregulated Nutrient Sensing | Mechanisms responsible for lipodystrophy, dyslipidemia and insulin resistance (IR) occurrence have not been completely understood. | 25166438 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | The increased concentration of FFAs is suggested to be the triggering event in the development of hypertriglyceridemia and insulin resistance during ARV therapy. | 25166438 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. | 25167838 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | To test hypothetical benefits of SIRT1 overexpression, we crossbred PrP-Sirt1 mice with two lines of ALS model mice: A high expression line that exhibits a severe phenotype (SOD1G93A-H) or a low expression line with a milder phenotype (SOD1G93A-L). | 25167838 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | The genetic supplementation of SIRT1 can ameliorate a mutant SOD1-linked ALS mouse model partly through the activation of the HSF1/HSP70i chaperone system. | 25167838 |
| Dyslipidemias | Deregulated Nutrient Sensing | Higher achieved BP values tended to be associated with an increased CVD risk in both the patients with and without dyslipidemia. | 25168847 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | At the time of the coronary event, CVRF were highly prevalent (60.5% hypertension, 48% dyslipidemia, and 16% diabetes mellitus). | 25170515 |
| Neoplasms | Deregulated Nutrient Sensing | We hypothesized that the elevated b-HCG and possibly other placental hormones from the germ cell tumor caused her to develop insulin resistance and inadequate b-cell insulin secretory response. | 25171445 |
| Dyslipidemias | Deregulated Nutrient Sensing | A previous study reported that the myosin regulatory light chain interacting protein (MYLIP) might serve as a novel therapeutic class for treating dyslipidemia. | 25171759 |
| Obesity | Deregulated Nutrient Sensing | Future studies should investigate whether a reduction in obesity and insulin resistance may prevent the adverse cardiovascular consequences of altered autonomic function. | 25171899 |
| Hyperlipidemia, Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | In familial combined hyperlipidemia (FCHL) the severity of the dyslipidemia is determined by an overproduction of VLDL (very low density lipoprotein) particles and by its abnormal lipid composition. | 25172037 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | To report additional ocular outcomes of intensive treatment of hyperglycemia, blood pressure, and dyslipidemia in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. | 25172198 |
| Dyslipidemias | Deregulated Nutrient Sensing | The dyslipidemia trial compared fenofibrate plus simvastatin with placebo plus simvastatin. | 25172198 |
| Dyslipidemias, Blood Glucose | Deregulated Nutrient Sensing | As previously reported, there were significant reductions in the primary outcome in the glycemia and dyslipidemia trials, but no significant effect in the blood pressure trial. | 25172198 |
| Inflammation | Deregulated Nutrient Sensing | Previous studies have suggested that this is due partly to lower levels of inflammation and insulin resistance. | 25173442 |
| Malignant tumor of colon, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia, insulin resistance, and oxidative stress indices were worsened in obese patients with colon cancer. | 25173531 |
| Dyslipidemias, Cardiovascular Diseases, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia and elevated lipoprotein(a) are risk factors for adult cardiovascular disease and stroke. | 25174567 |
| Neoplasms | Deregulated Nutrient Sensing | The tumor suppressor LKB1 gene is a master kinase and inhibits mammalian target of rapamycin (mTOR) by activating AMP-activated protein kinase (AMPK) and AMPK-related kinases. | 25179843 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Sirt1 regulates canonical TGF-b signalling to control fibroblast activation and tissue fibrosis. | 25180292 |
| Sample Size Calculation, Systemic Scleroderma | Deregulated Nutrient Sensing | As aberrant epigenetic modifications have been linked to the pathogenesis of systemic sclerosis (SSc), we aimed to investigate the role of Sirt1 in fibroblast activation. | 25180292 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | The role of Sirt1 was evaluated in bleomycin-induced skin fibrosis and in mice overexpressing a constitutively active transforming growth fac-tor-b (TGF-b) receptor I (TBRIact). | 25180292 |
| Sample Size Calculation, Fibrosis Assessment | Deregulated Nutrient Sensing | The expression of Sirt1 was decreased in patients with SSc and in experimental fibrosis in a TGF-b-dependent manner. | 25180292 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Consistently, mice with fibroblast-specific knockdown of Sirt1 were less susceptible to bleomycin- or TBRIact-induced fibrosis. | 25180292 |
| Sample Size Calculation | Deregulated Nutrient Sensing | We identified Sirt1 as a crucial regulator of TGF-b/Smad signalling in SSc. | 25180292 |
| Sample Size Calculation | Deregulated Nutrient Sensing | Although Sirt1 is downregulated, this decrease is not sufficient to counterbalance the excessive activation of TGF-b signalling in SSc. | 25180292 |
| Sample Size Calculation | Deregulated Nutrient Sensing | Sirt1 may thus be a key regulator of fibroblast activation in SSc. | 25180292 |
| Increased insulin level, Hypertriglyceridemia, Fatty degeneration, Hyperglycemia | Deregulated Nutrient Sensing | Simple steatosis, hyperinsulinemia, hyperglycemia, insulin resistance, hypertriglycemia and marked increases in hepatic CYP2E1 and 4-HNE were present in 30-wk-old untreated OLETF rats. | 25180626 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The T-455C and C-482T polymorphisms of the APOC3 gene are not associated with risk of NAFLD, pathogenic changes in lipid profiles, or insulin resistance in Han Chinese. | 25180874 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | We investigated the associations between breakfast consumption (frequency and content) and risk markers for type 2 diabetes (particularly insulin resistance and glycaemia) and cardiovascular disease in children. | 25181492 |
| Carcinoma of lung, Malignant Neoplasms | Deregulated Nutrient Sensing | Sirt1 was reported to be overexpressed in many cancers, including lung cancer. | 25184156 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Sirtinol, a specific inhibitor of Sirt1, has been shown to induce apoptosis of cancer cells by elevating endogenous level of reactive oxygen species. | 25184156 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Overall, this study demonstrates that sirtinol attenuates the proliferation and induces apoptosis of NSCLC cells, indicating the potential treatment against NSCLC cells by inhibiting Sirt1 in future applications. | 25184156 |
| Fibrosis Assessment, Fatty degeneration, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia. | 25186086 |
| Fibrosis Assessment, Fatty degeneration, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | To evaluate the prognostic value of non-invasive biomarkers of liver fibrosis (FibroTest) and steatosis (SteatoTest) in patients with type-2 diabetes and/or dyslipidaemia. | 25186086 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | FibroTest has prognostic value for predicting overall survival in patients with type-2 diabetes and/or dyslipidaemia. | 25186086 |
| Obesity | Deregulated Nutrient Sensing | Obesity modifies the association between serum 25-hydroxyvitamin D and insulin resistance in Korean general population without increased fasting glucose levels. | 25186304 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Dysregulation of AMPK signaling has been observed in Alzheimer's disease (AD), which is associated with abnormal neuronal energy metabolism. | 25186765 |
| Depression, CTCAE | Deregulated Nutrient Sensing | We found that amyloid b (Ab)-induced inhibition of long-term potentiation (LTP) and enhancement of long-term depression were corrected by the AMPK inhibitor compound C (CC). | 25186765 |
| Failure (biologic function) | Deregulated Nutrient Sensing | In addition, Ab-induced LTP failure was prevented in mice with genetic deletion of the AMPK a2-subunit, the predominant AMPK catalytic subunit in the brain. | 25186765 |
| Hyperactive behavior, Data types - Address | Deregulated Nutrient Sensing | Furthermore, we found that eukaryotic elongation factor 2 (eEF2) and its kinase eEF2K are key downstream effectors that mediate the detrimental effects of hyperactive AMPK in AD pathophysiology. | 25186765 |
| Data types - Address, SMAD1 protein, human | Deregulated Nutrient Sensing | Our findings describe a previously unrecognized role of aberrant AMPK signaling in AD-related synaptic pathophysiology and reveal a potential therapeutic target for AD. | 25186765 |
| Shock, Asthma, Heat-Shock Response, Intimal proliferation | Deregulated Nutrient Sensing | Heat shock protein 20 (HSP20), which is a member of the small heat shock protein family, is known to participate in many pathological processes, such as asthma, intimal hyperplasia, and insulin resistance. | 25187324 |
| Dyslipidemias | Deregulated Nutrient Sensing | Elevated resting heart rate is associated with dyslipidemia in middle-aged and elderly Chinese. | 25189606 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Their resting heart rate was monitored and their serum levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured to define dyslipidemia according to the 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. | 25189606 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics. | 25189993 |
| Neoplasms | Deregulated Nutrient Sensing | Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target. | 25189993 |
| Neoplasms, Primary malignant neoplasm, Toxic effect | Deregulated Nutrient Sensing | JQ-101 suppressed cancer cell growth and survival by targeting SIRT1, and also exhibited selective cytotoxicity towards a panel of human tumor cell lines, while producing no toxicity in two normal human cell types at comparable concentrations. | 25189993 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | In summary, we have identified JQ-101 as a new SIRT1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion. | 25189993 |
| Cardiomyopathies, Diabetes Mellitus | Deregulated Nutrient Sensing | Importance should be given to the examination of clinical aspects as well as the interdisciplinary follow-up for proper detection of insulin resistance and diabetes, early puberty, cardiomyopathy, among others. | 25192534 |
| diabetic | Deregulated Nutrient Sensing | The key cardiac pro-survival cellular signals including AMPK, Akt, ERK1/2, and GSK3a/b were impaired in the diabetic hearts, but the administration of desacyl ghrelin attenuated these signalling impairments. | 25192951 |
| Cardiac dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results collectively demonstrate that desacyl ghrelin protects the heart against cardiac dysfunction in type 2 diabetic mice by inhibiting excessive collagen deposition and enhancing cardiac autophagic signalling via the pro-survival cellular AMPK/ERK1/2 signalling pathways. | 25192951 |
| Dyslipidemias, Coronary Artery Disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity is a major risk factor for arterial hypertension, coronary artery disease, dyslipidemias, and type 2 diabetes. | 25194752 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence and determinants of dyslipidemia patterns among Hispanics/Latinos are not well known. | 25195188 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dominicans consistently had a lower prevalence of most types of dyslipidemia. | 25195188 |
| Dyslipidemias | Deregulated Nutrient Sensing | In multivariate analyses, the presence of any dyslipidemia was associated with increasing age, body mass index, and low physical activity. | 25195188 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Older age, female sex, diabetes, low physical activity, and alcohol use were associated with specific dyslipidemia types. | 25195188 |
| Dyslipidemias | Deregulated Nutrient Sensing | Spanish-language preference and lower educational status were associated with higher dyslipidemia prevalence. | 25195188 |
| Nonalcoholic Steatohepatitis | Deregulated Nutrient Sensing | Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. | 25195551 |
| Hepatobiliary Disorder | Deregulated Nutrient Sensing | A total of 239 patients were recruited and state-of-the-art techniques were used to measure insulin resistance (euglycemic insulin clamp with 3-(3)H-glucose), liver fat accumulation (magnetic resonance spectroscopy or (1)H-MRS), total body fat (dual energy X-ray absorptiometry), and severity of liver disease (liver biopsy). | 25195551 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Although patients with NASH had higher insulin resistance, plasma vitamin D concentrations were similar between both groups. | 25195551 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Our results suggest that plasma vitamin D levels are not associated with insulin resistance, the amount of liver fat accumulation, or the severity of NASH. | 25195551 |
| Idiopathic hirsutism | Deregulated Nutrient Sensing | A threshold of 74.5 cm for waist circumference had the optimal combined sensitivity and specificity for prediction of insulin resistance in women with idiopathic hirsutism, though this value was 90.5 cm for controls. | 25200999 |
| Dyslipidemias | Deregulated Nutrient Sensing | Specifically, the a-carotene and b-cryptoxanthin LSCRS were associated with a lower odds of HDL-C dyslipidaemia. | 25201307 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is prevalent in reproductive-aged women and confounded by metabolic morbidities, including insulin resistance and type 2 diabetes. | 25207967 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Together, these data suggest in utero androgen excess combined with mild maternal glucose intolerance alter infant and adult islet morphology, implicating deviant islet development. | 25207967 |
| Neoplasms | Deregulated Nutrient Sensing | Our study relies on a 'signal transduction' hypothesis based on the crosstalk between LKB1/AMPK and PI3K/PTEN/Akt signaling at the level of the tumor suppressor protein FoxO3A. | 25208626 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Quality of care (QoC) was calculated by measuring provider performance on four indicators (antiplatelet therapy, dyslipidemia management, control of hypertension, and diabetes) derived from the ACCF/AHA PAD guidelines. | 25209120 |
| Thyroid carcinoma | Deregulated Nutrient Sensing | Insulin resistance is another factor that increases the risk of recurrence in patients with thyroid cancer. | 25209891 |
| In-Stent Restenosis Indicator | Deregulated Nutrient Sensing | Influence of insulin resistance on in-stent restenosis in patients undergoing coronary drug-eluting stent implantation after long-term angiographic follow-up. | 25211654 |
| In-Stent Restenosis Indicator | Deregulated Nutrient Sensing | Previous studies have reported that insulin resistance is related to early in-stent restenosis (ISR) after coronary stenting. | 25211654 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Relationships of plasma lipoprotein(a) levels with insulin resistance in hypertensive patients. | 25212579 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Insulin resistance and higher fasting insulin levels are associated with lower plasma Lp(a) in hypertensive patients. | 25212579 |
| Dyslipidemias, Hypertension, CTCAE, Atrial Fibrillation by ECG Finding, Diabetes Mellitus | Deregulated Nutrient Sensing | Frequencies of hypertension and diabetes mellitus were unchanged, whereas dyslipidemia, smoking, and atrial fibrillation significantly increased. | 25213341 |
| phosphorus 32 | Deregulated Nutrient Sensing | It is our hypothesis that activation of AMP-activated protein kinase (AMPK), a master regulator of cellular metabolism, may lead to a reduction in SRSF1 and thus a decrease in the use of the LMNA 5' cryptic splice site in exon 11 through upregulation of p32, a splicing factor-associated protein and putative mitochondrial chaperone that has been shown to inhibit SRSF1 and enhance mitochondrial DNA (mtDNA) replication and oxidative phosphorylation. | 25216752 |
| Disease | Deregulated Nutrient Sensing | AMPK activation by currently available compounds such as metformin, resveratrol, and berberine may thus have wide-ranging implications for disorders associated with increased production and accumulation of progerin. | 25216752 |
| Impaired cognition, Demographics Domain | Deregulated Nutrient Sensing | These results suggest that cognitive and affective decline in DM patients was mostly related to glucose control and insulin resistance, whilst amongst late elderly subjects the impairment of 'attention' and 'orientation' were characteristic features of DM patients. | 25220803 |
| Prostate Cancer Outcomes Study, metabolic disturbance | Deregulated Nutrient Sensing | The decrease of SHBG level was also a risk factor for insulin resistance in both PCOS and metabolic disturbance. | 25223276 |
| Osteoporosis, Dyslipidemias, Behavior Disorders, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with SCS have a high prevalence of "lifestyle-related diseases," such as hypertension, diabetes mellitus, dyslipidemia, and osteoporosis. | 25223468 |
| diabetic | Deregulated Nutrient Sensing | Fresh pomegranate juice ameliorates insulin resistance, enhances b-cell function, and decreases fasting serum glucose in type 2 diabetic patients. | 25223711 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Generally, the results demonstrated decreased FSG, increased b-cell function, and decreased insulin resistance among T2D participants, 3 hours after PJ administration (P < .05). | 25223711 |
| Huntingtons Disease Pathway | Deregulated Nutrient Sensing | An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease. | 25223731 |
| HD Term Type, "Huntingtons Disease Pathway | Deregulated Nutrient Sensing | Selisistat, a selective SirT1 inhibitor is being developed as a potentially disease-modifying therapeutic for Huntington's disease (HD). | 25223731 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Cardiovascular risk and prevention may be improved in revascularized diabetic patients in Spain through further control of risk factors, particularly dyslipidemia. | 25224523 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | However, endothelial dysfunction on the one hand and type 2 diabetes mellitus, impaired glucose metabolism (IGM), and insulin resistance on the other may act synergistically (ie, interact) in the development of cardiovascular disease. | 25225211 |
| Immunoglobulin M, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We therefore investigated the interaction between endothelial dysfunction and type 2 diabetes mellitus, IGM, and insulin resistance with regard to risk of cardiovascular events. | 25225211 |
| Immunoglobulin M, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Interaction between flow-mediated dilatation and type 2 diabetes mellitus, IGM, or insulin resistance was present on an additive (relative excess risk caused by interaction>0) and on a multiplicative scale (P interaction<0.05). | 25225211 |
| Immunoglobulin M, Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Endothelial dysfunction and type 2 diabetes mellitus, IGM, or insulin resistance synergistically increase cardiovascular event risk. | 25225211 |
| Autoimmune Diseases, Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-Dependent, Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Islet autoimmunity identifies a unique pattern of impaired pancreatic beta-cell function, markedly reduced pancreatic beta cell mass and insulin resistance in clinically diagnosed type 2 diabetes. | 25226365 |
| Osteoporosis | Deregulated Nutrient Sensing | We performed a prospective monocentric study of patients with osteoporosis and measured the nuclear and cytoplasmic activities of SIRT1 in PBMCs. | 25228047 |
| Osteoporosis | Deregulated Nutrient Sensing | Sirtuin 1 activity in peripheral blood mononuclear cells of patients with osteoporosis. | 25228047 |
| PPARG wt Allele | Deregulated Nutrient Sensing | The conserved acetylation sites of Pparg1 and the catalytic domain of SIRT1 are both required for the interaction between Pparg1 and SIRT1. | 25229978 |
| Obesity | Deregulated Nutrient Sensing | Vitamin D deficiency is associated with insulin resistance in nondiabetics, which is independent of obesity. | 25230322 |
| Progranulins | Deregulated Nutrient Sensing | Progranulin (PRGN) was recently identified as one of the adipokines involved in the development of insulin resistance. | 25231693 |
| Dyslipidemias | Deregulated Nutrient Sensing | Common vascular risk factors (dyslipidemia, smoking, and sex) were similar for normal, low, and incompressible ABix. | 25231881 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic b-cell function, and inflammation. | 25233153 |
| Chronic Obstructive Airway Disease, Hypertension, CTCAE, Depression, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Other variables: gender, age, depression, asthma/chronic obstructive pulmonary disease, hypertension, dyslipidemia, insulin, pills, smoking, walking, baseline blood glucose and creatinine. | 25234387 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced b-cell mass, partially due to an increased b-cell apoptosis rate. | 25234740 |
| Inflammation, square decimeter, Obesity | Deregulated Nutrient Sensing | Chronic inflammation is linked to disorders of obesity, insulin resistance and DM2. | 25236830 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was diagnosed in 19%, dyslipidemia in 27%, and diabetes mellitus in 3%. | 25238104 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | The creation of a transverse aortic constriction (TAC) provoked more severe DD and LV fibrosis in Sirt1(endo-/-) compared with control TAC animals. | 25239805 |
| Diastolic dysfunction | Deregulated Nutrient Sensing | Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction. | 25239805 |
| Cardiomyopathies | Deregulated Nutrient Sensing | Sirtuin 1 expression declines with age; therefore we explored the role played by angiogenesis and Sirtuin 1 in the development of cardiomyopathy. | 25239805 |
| Dyslipidemias | Deregulated Nutrient Sensing | Added sugar consumption seems to trigger a hyperinflammatory state and may result in visceral adiposity, dyslipidemia, and insulin resistance. | 25240081 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Impacts of diet quality on insulin resistance, as a sign of metabolism perturbation, deserve more attention in this indigenous population with high rates of obesity and diabetes. | 25240691 |
| palladium, Overweight, Dysglycemia | Deregulated Nutrient Sensing | Overweight adolescents with PD have an atherogenic lipoprotein profile of small LDL and HDL size and increased concentrations of small LDL, moderated by insulin resistance and visceral adiposity, but independently driven by dysglycemia for LDL size. | 25240909 |
| Oxygen saturation below reference range, Slow shallow breathing | Deregulated Nutrient Sensing | Correlations between Apneea Hypopnea Index (AHI), Oxygen Desaturation Index (ODI), average and lowest oxyhaemoglobin saturation (SaO), body mass index (BMI) and insulin resistance or sensitivity were assesed. | 25241557 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | A subcutaneous adipose tissue biopsy displayed changes in gene and protein expression that could contribute to the clinical improvement of hyperglycemia and dyslipidemia. | 25242791 |
| Hypoxia | Deregulated Nutrient Sensing | Furthermore, we observed a consistent reduction of tubule-like formation and migration and we found that SIRT1 inhibition reduced the hypoxia induced accumulation of HIF-1a protein and its transcriptional activity in hMSCs. | 25243179 |
| Spinal Cord Ischemia | Deregulated Nutrient Sensing | Our findings identify SIRT1 as regulator of hypoxia-induced response in hMSCs and may contribute to the development of new therapeutic strategies to improve regenerative properties of mesenchymal stem cells in ischemic disorders through SIRT1 modulation. | 25243179 |
| Acid reflux, Quadriplegia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | This 68-year-old male with chronic incomplete tetraplegia, dyslipidemia, and well-controlled diabetes mellitus underwent Roux-en-Y gastric bypass surgery (RYGBP) for intractable biliary reflux. | 25243335 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Surrogate markers reflecting b-cell dysfunction were more closely associated with diabetes conversion than insulin resistance indices. | 25245975 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | The effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease. | 25252293 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | Particularly, the relation between 2827 A>G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet. | 25252293 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated oxidative stress contributes to the development of such obesity-related diseases as dyslipidemia, diabetes mellitus and hypertension. | 25252747 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Hyperlipidemia | Deregulated Nutrient Sensing | Low-grade inflammation, characterized by increased pro-inflammatory cytokine levels, is present in patients with obesity-linked insulin resistance, hyperglycemia and hyperlipidemia and considered to play a leading role to progression into type 2 diabetes (T2D). | 25254631 |
| Thrombosis, Dyslipidemias, Venous Thromboembolism, vinyltriethoxysilane | Deregulated Nutrient Sensing | Dyslipidemia is a well-known risk factor for the development of atherothrombosis; however, its involvement in venous thromboembolism (VTE) is still debated. | 25256037 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Activation of AMP-activated protein kinase a1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. | 25256353 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | In this study, we demonstrate that cytoplasmic mislocalization of TDP-43 was accompanied by increased activation of AMP-activated protein kinase (AMPK) in motor neurons of ALS patients. | 25256353 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | The activation of AMPK in a motor neuron cell line (NSC34) or mouse spinal cords induced the mislocalization of TDP-43, recapitulating this characteristic of ALS. | 25256353 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Our findings demonstrate that activation of AMPK-a1 plays a critical role in TDP-43 mislocalization and the development of ALS; thus, AMPK-a1 may be a potential drug target for this devastating disease. | 25256353 |
| Dyslipidemias, Sleep Apnea Syndromes, Degenerative polyarthritis, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with very high to extremely high WRHR often had type 2 diabetes mellitus; hypertension; dyslipidaemia; osteo arthritis; and sleep apnoea. | 25257816 |
| IFNG wt Allele, Glucose Intolerance (disease), Depressed mood, Demographics Domain | Deregulated Nutrient Sensing | A depressed mood for 2 or more continuous weeks was reported by 13.6% of subjects with normal glucose tolerance (NGT), 14.3% of those with impaired glucose intolerance (IFG), and 17.6% of DM patients. | 25258359 |
| Glucose Intolerance (disease), Obesity, Primary malignant neoplasm | Deregulated Nutrient Sensing | PDAC has been linked with obesity and glucose intolerance, but whether changes in circulating metabolites are associated with early cancer progression is unknown. | 25261994 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Haiti, Hypertension, CTCAE, Dental Plaque | Deregulated Nutrient Sensing | The purpose of this study was to investigate the difference of coronary artery disease (CAD) severity and extent as well as plaque characteristics between patients with either one of hypertension (HT), diabetes mellitus (DM) or dyslipidemia (DL). | 25262436 |
| Chronic liver disease | Deregulated Nutrient Sensing | Insulin resistance has been described in association with chronic liver disease for decades. | 25263463 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Contrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up. | 25264116 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is commonly proposed as a precursor to both type 2 diabetes and cardiovascular disease (CVD), yet few studies have directly compared insulin resistance with both outcomes simultaneously and determined whether associations with each outcome differ in strength or are comparable. | 25264116 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our data support insulin resistance as a predictor of diabetes in later life but, perhaps surprisingly, suggest this pathway is of negligible importance to CVD outcomes in the elderly. | 25264116 |
| Inflammation | Deregulated Nutrient Sensing | Increased permeability and uptake of proinflammatory bacterial endotoxins from gut microbiota has been suggested as a mechanism for obesity-associated chronic inflammation that causes obesity-associated insulin resistance. | 25264329 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Therefore, because ALT is correlated with dyslipidemia, insulin resistance, and central fat distribution, it might also serve as a marker of risk for adiposity-related co-morbidities beyond NAFLD. | 25266069 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Several markers of iron metabolism have been associated with insulin resistance (IR) and type 2 diabetes mellitus in cross-sectional studies. | 25267079 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance has an important role in the pathogenesis of hypertension. | 25267735 |
| Hypertensive (finding), Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | At baseline, the prevalence of abdominal obesity, dyslipidemia, and IGT was higher in subjects who became hypertensive compared to those that remained normotensive. | 25267735 |
| Endometrial Neoplasms | Deregulated Nutrient Sensing | SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. | 25270091 |
| Carcinogenesis, Neoplasms | Deregulated Nutrient Sensing | Recent studies have revealed that SIRT1 plays a dual role as a tumor suppressor and a tumor promoter in multiple stages of carcinogenesis. | 25270091 |
| Endometrial Neoplasms, Neoplasms | Deregulated Nutrient Sensing | These results demonstrated that SIRT1 may play a role as a tumor promoter in EC and can promote endometrial tumor growth by promoting lipogenesis. | 25270091 |
| Carotid Atherosclerosis | Deregulated Nutrient Sensing | Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort. | 25273948 |
| atherosclerotic | Deregulated Nutrient Sensing | SIRT1 and FOXO1 interact with each other in multiple pathways regulating aging, metabolism and resistance to oxidative stress and control different pathways involved in atherosclerotic process. | 25273948 |
| Atherosclerosis | Deregulated Nutrient Sensing | It is not known, if genetic polymorphisms (SNPs) at the SIRT1 and FOXO1 have an influence on carotid atherosclerosis. | 25273948 |
| Carotid Atherosclerosis | Deregulated Nutrient Sensing | This study demonstrated associations of genetic variations at the SIRT1 and FOXO1 loci with carotid atherosclerosis and highlighted the need for further investigation by functional studies. | 25273948 |
| Diabetic Retinopathy, Diabetes Mellitus, Non-Insulin-Dependent, GDC Disease Response Terminology | Deregulated Nutrient Sensing | This study was designed to investigate the association between the polymorphisms in three insulin resistance-related genes, uncoupling protein-1 (UCP1), peroxisome proliferator-activated receptor g (PPARg) and transcription factor 7-like 2 (TCF7L2) and the susceptibility to diabetic retinopathy (DR) in a Chinese type 2 diabetes mellitus (T2DM) cohort. | 25274455 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The occurrence of the MS process mostly began with overweight or obesity and dyslipidemia in young people. | 25280459 |
| Hypertensive disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Thirteen patients (19.1 %) had HTN; 7 (10.2 %) had dyslipidemia and 6 (8.8 %) had diabetes not requiring treatment. | 25282446 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | A comprehensive cardiovascular disease (CVD) risk factor profile was assessed including demographics, environmental and biochemical risk factors including insulin resistance and troponin-T levels. | 25283732 |
| Dyslipidemias, Coronary heart disease, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Multiple logistic regression analysis revealed that the significant predictors of vitamin D deficiency included coronary heart disease (CHD), obesity, dyslipidemia, older age, female sex, and smoking (all P<0.05), whereas tea intake, moderate physical activity, milk intake, vitamin D supplementation and sun exposure were protective (all P<0.05). | 25284157 |
| Dyslipidemias, Obesity, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Vitamin D deficiency is prevalent in the middle-aged and elderly northwestern Chinese population and is largely attributed to CHD, obesity, dyslipidemia, older age, female sex, and smoking. | 25284157 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | These patients were younger (median 56.7 vs. 62.1years, P<0.0001) and more often current smokers (52.4% vs. 43.5%, P<0.0001), had more dyslipidemia (47.7% vs. 41.1%, P=0.0003), less diabetes mellitus (14.1% vs. 17.5%, P=0.01) and had shorter symptom onset to balloon times (median 213 vs. 225 min, P=0.02). | 25288517 |
| Non-alcoholic Fatty Liver Disease, Impaired health | Deregulated Nutrient Sensing | This impairment may affect HSP70-dependent anti-inflammation, with consequent oxidative stress and insulin resistance in advanced stages of NAFLD. | 25292174 |
| Dyslipidemias, Atherosclerosis, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia is a major contributor to the development of atherosclerosis and coronary disease. | 25292185 |
| Obesity | Deregulated Nutrient Sensing | The reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity. | 25296075 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and its association with insomnia in a community based population in China. | 25297696 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | Studies of the prevalence of dyslipidemia and its association with insomnia are scarce in China. | 25297696 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | This study investigated the prevalence of dyslipidemia and its association with insomnia in a community based Chinese population. | 25297696 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | The association between self-reported insomnia and dyslipidemia was determined by multiple logistic regression models. | 25297696 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia in those with no insomnia, occasional insomnia, and frequent insomnia were 53.3%, 54.3%, and 54.5% in men and 52.0%, 54.8%, and 61.2% in women. | 25297696 |
| Sleeplessness, Dyslipidemias | Deregulated Nutrient Sensing | These observations indicate that frequent insomnia was associated with a higher prevalence of dyslipidemia in women. | 25297696 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Hypothyroidism is one of the most common causes of secondary dyslipidemias which results from reduced LDL clearance and therefore raised levels of LDL and apoB. | 25300222 |
| Hypoalphalipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | The most frequent MS group was hypoalphalipoproteinemia in females (51.3%) and mixed dyslipidemia in males (43.5%). | 25300324 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Management of dyslipidemia in high-risk patients with preexistent CAD or stroke continues to be suboptimal. | 25300975 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Our results suggest that the expression of alpha-defensins 1, 2 and 3 genes is involved in dyslipidemia in patients with hypercholesteremia. | 25300997 |
| Obesity, Abdominal, Overweight | Deregulated Nutrient Sensing | Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study. | 25301371 |
| Overweight | Deregulated Nutrient Sensing | However, these associations are unclear amongst overweight adolescents who have already developed insulin resistance. | 25301371 |
| Overweight | Deregulated Nutrient Sensing | The risk of insulin resistance amongst overweight adolescents increases significantly when they reach a waist circumference > p95 (OR = 1.9, CIs = 1.3-2.7, p = 0.013) and watch 3 or more hours/day of television (OR = 1.7, CIs = 0.98-2.8, p = 0.033). | 25301371 |
| Overweight | Deregulated Nutrient Sensing | Sedentary behaviour and a waist circumference > p90 amongst overweight adolescents were associated with insulin resistance, lipid profile alterations, and higher inflammatory states. | 25301371 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | We conclude that the android/gynoid fat ratio is closely associated with insulin resistance and LDL + VLDL-, "bad," cholesterol in normal weight boys and may provide a measurement of metabolic and cardiovascular disease risk in that population. | 25302115 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance. | 25303484 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Compared to non-obese patients without NAFLD, patients with NAFLD had severe systemic (liver/muscle), and particularly, adipose tissue (fasting/postprandial) insulin resistance (all p<0.01). | 25303488 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance is considered one of the major risk factors for the development of type 2 diabetes mellitus (T2DM). | 25303644 |
| Atherosclerosis | Deregulated Nutrient Sensing | The triglycerides-to-high-density lipoprotein-cholesterol (TG/HDL-C) ratio has been identified as a biomarker of insulin resistance and a predictor for atherosclerosis. | 25304295 |
| One Vessel Coronary Disease, Dyslipidemias, Diabetes Mellitus, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | All had chronic stable angina, 75% had dyslipidemia, 58% had hypertension, 50% had peripheral arterial disease, 42% had diabetes and 50% had multivessel disease. | 25304770 |
| Dyslipidemias, Prostate carcinoma | Deregulated Nutrient Sensing | Given that prostate cancer and dyslipidemia affect large proportions of Western society, understanding these associations has public health importance. | 25304929 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, among men with dyslipidemia, elevated cholesterol and HDL levels were associated with increased and decreased risk of recurrence, respectively. | 25304929 |
| RANGAP1 wt Allele, Frontotemporal dementia | Deregulated Nutrient Sensing | Both patients with bvFTD and those with SD have increased triglyceride and insulin levels and lower HDL cholesterol levels compared with controls, suggesting a state of peripheral insulin resistance. | 25305153 |
| Nerve Degeneration | Deregulated Nutrient Sensing | These factors have been found to affect prognosis in motor neuron disease favorably, although insulin resistance has been proposed as a mechanism promoting neurodegeneration. | 25305153 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. | 25305670 |
| Myeloid Leukemia, Chronic, Dyslipidemias | Deregulated Nutrient Sensing | Statin therapy for dyslipidemia was associated with a lower incidence of multiple lesions and a lower concentration of CML in the protein sample (P = .004 and P = .02, respectively). | 25307432 |
| Dyslipidemias, Overweight, Hypertension, CTCAE, diabetic | Deregulated Nutrient Sensing | Diabetic patients were significantly older, had a worse cardiovascular risk profile (higher prevalence of overweight, dyslipidemia, hypertension and sedentary lifestyle) and lower functional capacity. | 25307705 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | The aim of this study was to investigate the clinical prognostic value of the histone deacetylases SIRT1, HDAC1 and HDAC2 and the histone modifications H4K16Ac and H3K56Ac in colorectal cancer. | 25307864 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease. | 25310839 |
| Impaired T cell function, Metabolic Syndrome X | Deregulated Nutrient Sensing | Our findings suggest that environmental exposure to PAHs independent of cigarette smoking is associated with insulin resistance, b-cell dysfunction, and increased prevalence of metabolic syndrome. | 25310882 |
| Dyslipidemias, Liver Cirrhosis | Deregulated Nutrient Sensing | Reduced dyslipidemia in patients with cirrhosis is associated with increased insulin resistance and possibly failed lipid synthesis. | 25311381 |
| Hepatobiliary Disorder, Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Although NAFLD is associated with dyslipidemia, it is not clear whether recently identified markers of cardiovascular risk indicate liver disease progression in patients with histologically confirmed NAFLD. | 25311381 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is related to increased insulin-induced hepatic lipid synthesis in patients with NAFLD. | 25311381 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Among the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial. | 25311932 |
| Malignant neoplasm of liver, Weight decreased, Obesity | Deregulated Nutrient Sensing | The epigenetic age acceleration, which is not reversible in the short term after rapid weight loss induced by bariatric surgery, may play a role in liver-related comorbidities of obesity, such as insulin resistance and liver cancer. | 25313081 |
| Dyslipidemias, Bipolar Disorder, diabetic | Deregulated Nutrient Sensing | Waist-to-hip ratio, dyslipidemia, glycemic levels, blood pressure and depressive symptoms among diabetic and non-diabetic Chinese women: a cross-sectional study. | 25314156 |
| Dyslipidemias, Bipolar Disorder, diabetic | Deregulated Nutrient Sensing | To explore the relationship between depressive symptoms and waist-to-hip ratio, dyslipidemia, glycemic levels or blood pressure among diabetic and non-diabetic Chinese women. | 25314156 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Cerebrovascular accident, Hypertension, CTCAE | Deregulated Nutrient Sensing | Data on demographic information, lifestyle, history of diabetes mellitus, stroke, coronary heart disease, hypertension, and dyslipidemia were collected. | 25316225 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Copious evidence from epidemiological and laboratory studies has revealed that sleep status is associated with glucose intolerance, insulin resistance, thus increasing the risk of developing type 2 diabetes. | 25316226 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A single mechanism can explain network-wide insulin resistance in adipocytes from obese patients with type 2 diabetes. | 25320095 |
| Lipodystrophy, Dyslipidemias | Deregulated Nutrient Sensing | Older age, increased duration of treatment and dyslipidaemia were found to be associated in patients with lipodystrophy than those without. | 25320591 |
| Impaired T cell function | Deregulated Nutrient Sensing | Oxidative stress has been hypothesised to contribute to the development of insulin resistance and b-cell dysfunction, the two key events in the clinical development of T2DM. | 25322842 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Little is known about the impact of insulin resistance on bipolar disorder. | 25323142 |
| Diabetes Mellitus, Bipolar Disorder | Deregulated Nutrient Sensing | To examine the relationships between insulin resistance, type 2 diabetes and clinical course and treatment outcomes in bipolar disorder. | 25323142 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We diagnosed type 2 diabetes and determined insulin resistance. | 25323142 |
| Diabetes Mellitus, Non-Insulin-Dependent, Bipolar Disorder | Deregulated Nutrient Sensing | Patients with bipolar disorder and type 2 diabetes or insulin resistance had three times higher odds of a chronic course of bipolar disorder compared with euglycaemic patients (50% and 48.7% respectively v. 27.3%, odds ratio (OR) = 3.07, P = 0.007), three times higher odds of rapid cycling (38.5% and 39.5% respectively v. 18.2%, OR = 3.13, P = 0.012) and were more likely to be refractory to lithium treatment (36.8% and 36.7% respectively v. 3.2%, OR = 8.40, P<0.0001). | 25323142 |
| GDC Comorbidity Terminology, Bipolar Disorder | Deregulated Nutrient Sensing | Comorbid insulin resistance may be an important factor in resistance to treatment in bipolar disorder. | 25323142 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | He had a medical history of well-controlled diabetes, hypertension and dyslipidaemia. | 25323280 |
| Endometrial Carcinoma, Dyslipidemias | Deregulated Nutrient Sensing | We previously reported an association between dyslipidemia and endometrial cancers. | 25324478 |
| Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | A common etiologic event has been proposed between dyslipidemia and osteoporosis. | 25324478 |
| Dyslipidemias, Malignant neoplasm of endometrium, Osteoporosis | Deregulated Nutrient Sensing | However, the pattern of interrelationships among dyslipidemia, osteoporosis and endometrial cancer is not well understood. | 25324478 |
| Cardiovascular system | Deregulated Nutrient Sensing | Paradoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans. | 25326285 |
| Chronic disease | Deregulated Nutrient Sensing | Insulin resistance is linked to many human chronic diseases. | 25326285 |
| glucose metabolism | Deregulated Nutrient Sensing | We formulated a novel hypothesis that insulin resistance can be beneficial in obese humans, insofar as it does not cause glucose dysmetabolism. | 25326285 |
| glucose metabolism | Deregulated Nutrient Sensing | Insulin resistance in obese individuals may begin as an adaptive mechanism and can be beneficial if it is not associated with glucose dysmetabolism. | 25326285 |
| Glucose Intolerance (disease), cardiac symptom | Deregulated Nutrient Sensing | Left axis deviation in electrocardiogram with normal QRS duration in ambulatory adults without cardiac symptoms: a possible marker of glucose intolerance. | 25327226 |
| Dyslipidemias, Atherosclerosis, Disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, a disorder in the levels of cholesterol or lipoproteins in the plasma, is a feature of atherosclerosis, leading to cardiovascular disease. | 25328922 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Morbidly obese patients are at risk of developing insulin resistance and cardiovascular disease. | 25329451 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Further studies are needed to determine whether the use of metformin will prevent the progression of insulin resistance to type 2 diabetes mellitus in obese women. | 25333776 |
| Dyslipidemias, Endothelial dysfunction, Pathology, Atherosclerosis | Deregulated Nutrient Sensing | Endothelial dysfunction is an early event in the progression of atherosclerosis, and it appears in pathologies such as dyslipidemias. | 25333861 |
| Malignant Head and Neck Neoplasm, diabetic | Deregulated Nutrient Sensing | Effect of L-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery. | 25335675 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Previous studies have found that L-arginine induced beneficial effects over insulin resistance both in type 2 diabetes mellitus patients and healthy individuals. | 25335675 |
| Malignant Head and Neck Neoplasm, Diabetes Mellitus | Deregulated Nutrient Sensing | Short-term enteral L-arginine therapy addeded to usual enteral nutrition of patients affected by head and neck cancer and surgery without diabetes mellitus type 2 is able to improve insulin resistance and adiponectin levels. | 25335675 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans. | 25337775 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | In this study, we examined the association between chronic kidney disease (CKD) and insulin resistance. | 25337775 |
| Uremia, Substance | Deregulated Nutrient Sensing | In the adipose tissue of nephrectomized rats, asymmetric dimethylarginine (ADMA; an uremic substance linking uremia and insulin resistance) increased, the expression of the ADMA-degrading enzymes DDAH1 and DDAH2 decreased, and the oxidative stress increased. | 25337775 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Thus, activation of mineralocorticoid receptor and resultant ADMA accumulation in adipose tissue has, in part, a relevant role in the development of insulin resistance in CKD. | 25337775 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum ferritin, diabetes, diabetes control, and insulin resistance. | 25338070 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The aim of our study was to show the influence of testosterone replacement therapy on obesity, HbA1c level, hypertension and dyslipidemia in patients with diabetes mellitus and androgen deficiency. | 25338765 |
| Sarcoma | Deregulated Nutrient Sensing | SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. | 25341037 |
| synovial sarcoma | Deregulated Nutrient Sensing | We show that SIRT1 is overexpressed in synovial sarcoma biopsies and cell lines in comparison with normal mesenchymal cells. | 25341037 |
| Dyslipidemias, Diabetes Mellitus, Obesity, vascular inflammations, Hypertension, CTCAE | Deregulated Nutrient Sensing | Some epidemiological studies have begun to show a possible correlation between systemic and vascular inflammation and the presence of essential hypertension, especially if it is associated with metabolic risk factors (obesity, dyslipidemia, diabetes mellitus). | 25341276 |
| Obesity | Deregulated Nutrient Sensing | The biological mechanisms linking obesity to insulin resistance have not been fully elucidated. | 25341798 |
| Obesity | Deregulated Nutrient Sensing | We sought to test the hypothesis that the balance of T-cell phenotypes would be similarly related to insulin resistance in human obesity. | 25341798 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | These findings point to the adaptive immune system as a potential mediator between obesity and insulin resistance or inflammation. | 25341798 |
| Alzheimers Disease", square decimeter, Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | Insulin resistance causes diminished glucose uptake in similar regions of the brain in Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2). | 25342129 |
| square decimeter, Data types - Address, Frontotemporal dementia | Deregulated Nutrient Sensing | Mean exosomal levels of extracted P-serine 312-IRS-1 and P-pan-tyrosine-IRS-1 by ELISA and the ratio of P-serine 312-IRS-1 to P-pan-tyrosine-IRS-1 (insulin resistance factor, R) for AD and DM2 and P-serine 312-IRS-1 and R for FTD were significantly different from those for case control subjects. | 25342129 |
| square decimeter, Data types - Address, Frontotemporal dementia | Deregulated Nutrient Sensing | Insulin resistance reflected in R values from this blood test is higher for patients with AD, DM2, and FTD than case control subjects; higher for patients with AD than patients with DM2 or FTD; and accurately predicts development of AD up to 10 yr prior to clinical onset. | 25342129 |
| Hypertension, CTCAE, Ischemic, Dyslipidemias | Deregulated Nutrient Sensing | Gender, age, hypertension, dyslipidaemia, family history, ischaemic ECG and positive troponin remained important factors. | 25344576 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Abnormalities of lipoprotein concentrations in obstructive sleep apnea are related to insulin resistance. | 25348129 |
| Dyslipidemias, Osage language | Deregulated Nutrient Sensing | Insulin resistance is also common in OSA, but its contribution to dyslipidemia of OSA is unclear. | 25348129 |
| Osage language | Deregulated Nutrient Sensing | The study's aim was to define the relationships among abnormalities of lipoprotein metabolism, clinical measures of OSA, and insulin resistance. | 25348129 |
| Sleep Apnea, Obstructive, Hypoxia, Osage language | Deregulated Nutrient Sensing | Pro-atherogenic lipoprotein abnormalities in obstructive sleep apnea (OSA) are related to insulin resistance, but not to OSA severity or degree of hypoxia. | 25348129 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance may represent the link between OSA-related dyslipidemia and increased cardiovascular disease risk. | 25348129 |
| Cardiovascular Diseases, Osage language, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Prevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia in these individuals. | 25348129 |
| Allergic asthma | Deregulated Nutrient Sensing | Insulin resistance is a risk for allergic asthma in obese children and adolescents. | 25348132 |
| Hypothermia due to exposure | Deregulated Nutrient Sensing | These results demonstrate increased resistance to insulin during mild induced hypothermia. | 25349023 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The increase in overweight and obese children and adolescents may be linked to increased rates of dyslipidaemia. | 25351644 |
| Dyslipidemias | Deregulated Nutrient Sensing | Low HDL-chol levels were the most prevalent dyslipidaemia in boys (6.4%) and high TChol in girls (9.1%). | 25351644 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients. | 25358448 |
| Steatohepatitis, Fatty degeneration | Deregulated Nutrient Sensing | SIRT1 was significantly lower in severe liver steatosis obese group compared to the mild steatosis group, both had lower SIRT1 plasma values compared to control lean patients (P = 0.0001). | 25358448 |
| Steatohepatitis | Deregulated Nutrient Sensing | SIRT1 showed an inverse correlation with liver steatosis and HbA1c in univariate analysis (r = -0.386; P = 0.001; r = -0.300; P = 0.01, respectively). | 25358448 |
| Steatohepatitis | Deregulated Nutrient Sensing | Multiple linear regression analysis showed that liver steatosis was the independent correlate of SIRT1 even after adjustment for potentially relevant variables (b = -0.442; P = 0.003). | 25358448 |
| Fatty Liver | Deregulated Nutrient Sensing | Serum SIRT1 might be a novel clinical/biochemical parameter associated with fat liver infiltration. | 25358448 |
| Inflammation, Dyslipidemias, Hyperglycemia | Deregulated Nutrient Sensing | Inflammation, hyper-glycaemia, dyslipidemia and oxidative stress have been associated with early stages of NCDs development whereas cohort surveys have demonstrated health benefits of dietary polyphenols from various dietary sources to reverse such progress. | 25358490 |
| Prediabetes syndrome, Coronary heart disease | Deregulated Nutrient Sensing | Modulation of coronary heart disease risk by insulin resistance in subjects with normal glucose tolerance or prediabetes. | 25358836 |
| Prediabetes syndrome, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | This study was based on the hypothesis that: (1) coronary heart disease (CHD) risk is accentuated in the insulin-resistant subset of persons with normal glucose tolerance (NGT) or prediabetes (PreDM); (2) the prevalence of insulin resistance, and associated abnormalities, is greater in subjects with PreDM; and (3) insulin resistance is the major contributor to increased CHD risk in these individuals. | 25358836 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Translational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer. | 25361980 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | DPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes. | 25368904 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The results indicate that teneligliptin acts not only to improve the blood glucose control, but also to improve the insulin resistance and serum lipid profile in Japanese type 2 diabetes patients. | 25368904 |
| Deterioration, diabetic | Deregulated Nutrient Sensing | The inverse association between lumbar spine TBS and insulin resistance may make it an indicator for determining skeletal deterioration in diabetic patients who have high BMD. | 25368976 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Prevalence of hypothyroidism in patients with dyslipidemia: Tehran Thyroid Study (TTS). | 25369072 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | In subjects with dyslipidemia and nondyslipidemia, the prevalence of subclinical was 7% and 4.1%, respectively, and for clinical hypothyroidism 3% and 1.2%, respectively. | 25369072 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | After adjusting for age and sex, hypothyroidism was not related to elevated serum lipid profiles in patient with dyslipidemia. | 25369072 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | In conclusion, there is significant difference in the prevalence of subclinical and clinical hypothyroidism between nondyslipidemic and dyslipidemic subjects; after adjustment for age and sex the presence of dyslipidemia did not predict the presence of hypothyroidism. | 25369072 |
| Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Atherosclerosis is a chronic and systemic disease and its developmental process involves the synergism of multiple risk factors such as hypertension, dyslipidemia, diabetes, obesity and smoking. | 25369320 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Disease activity score (DAS28), clinical and immunological parameters as well as traditional CV risk factors (diabetes, hypertension, dyslipidaemia and obesity) were registered from clinical records and all data were integrated using Principal Component Analysis (PCA). | 25369551 |
| Obesity | Deregulated Nutrient Sensing | The insulin resistance state did not mediate this association, while central obesity was a negative confounder. | 25370350 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Skeletal muscle is the key site of peripheral insulin resistance in type 2 diabetes. | 25370850 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Microarray analysis was performed using skeletal muscle cell cultures established from type 2 diabetic patients with a family history of type 2 diabetes and clinical evidence of marked insulin resistance and nondiabetic control subjects with no family history of diabetes. | 25370850 |
| FAM126A gene | Deregulated Nutrient Sensing | There are minor studies of the expression kinetics of mTORC1 and mTORC2 in HCC. | 25371154 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | 3) The shortest distances in the receiver operating characteristic curves for hypertension, dyslipidemia, diabetes, or >= 2 of these risk factors suggested that the WHR cutoffs were 0.92 or 0.91 for men and 0.86 or 0.85 for women. | 25376677 |
| Dyslipidemias, Peripheral Arterial Diseases, Obesity | Deregulated Nutrient Sensing | In multivariate analysis, peripheral artery disease was significantly associated with age (odds ratio (OR): 1.03; p = 0.004), dyslipidaemia (OR: 1.88; p = 0.003), smoking (OR: 1.78; p = 0.003), obesity (OR: 1.98; p = 0.034) and underweight (OR: 1.49; p = 0.023). | 25376847 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | A lesser degree of concordance was found for dyslipidemia (defined as drug use alone in SHS and FIRE, and ICD-10 code E78 in MEDSTAT), and for obesity (defined as BMI >= 30 kg/m(2) derived from self-reported height and weight in SHS, from measured height and weight or diagnosis of obesity in FIRE, and ICD-10 code E66 as secondary diagnosis in MEDSTAT). | 25377723 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | MEDSTAT performed well for clearly defined diagnoses (diabetes, hypertension), but underrepresented systematically more symptomatic conditions (dyslipidemia, obesity). | 25377723 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. | 25378371 |
| Diabetes Mellitus, Insulin-Dependent, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Deregulated Nutrient Sensing | To determine whether arterial elasticity differs between obese adolescents with clinical insulin resistance (IR), type 1 diabetes (T1D) and healthy non-obese controls. | 25381349 |
| Sepsis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Sepsis and type 2 diabetes exhibit insulin resistance as a common phenotype. | 25382802 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In type 2 diabetes we and others have recently provided evidence that alterations of the proinflammatory wingless-related integration site (wnt)-5a/anti-inflammatory secreted frizzled-related protein (sFRP)-5 system are involved in the pathogenesis of insulin resistance. | 25382802 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum aryl hydrocarbon receptor ligand activity is associated with insulin resistance and resulting type 2 diabetes. | 25385058 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals. | 25387258 |
| Prediabetes syndrome, Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between insulin resistance and b-cell dysfunction in subphenotypes of prediabetes and type 2 diabetes. | 25387263 |
| Proteinuria, IGA Glomerulonephritis, Dyslipidemias, Renal glomerular disease, Arteriolosclerosis, Simultaneous, Hyperuricemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | The characteristics of IgAN in advanced-age were lower renal function, high levels of proteinuria, severe interstitial change, and arteriolosclerosis caused by glomerulopathy and concomitant diseases, such as hypertension, dyslipidemia, and hyperuricemia. | 25388352 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, diabetes, dyslipidaemia, and major cardiovascular events (MACE) were more frequent in this group (P < 0.0001), but not tobacco (P < 0.0001). | 25389080 |
| Psoriasis, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Frequencies of comorbidities were not statically different but patients with 'early' onset psoriasis have a tendency (P < 0.5) to have higher frequencies of obesity, diabetes, dyslipidaemia, hypertension and MACE. | 25389080 |
| Parkinson Disease, Inflammation, Muscular Atrophy | Deregulated Nutrient Sensing | In rodent models of systemic inflammation, Parkinson's disease, or aging-related muscular atrophy, S-nitrosylation of SIRT1 correlated with increased acetylation of p53 and p65 and activation of p53 and NF-kB target genes, suggesting that S-nitrosylation of SIRT1 may represent a proinflammatory switch common to many diseases and aging. | 25389371 |
| Slow shallow breathing | Deregulated Nutrient Sensing | Compared with baseline data, the postoperative anthropometric characteristics, blood measurements, and sleep recording data, such as weight, apnea hypopnea index (AHI), and insulin resistance index, differed significantly (p < 0.001). | 25392079 |
| Inflammation, Hypertrophy | Deregulated Nutrient Sensing | In summary, we show that adipocyte hypertrophy is linked to increased inflammation in AT in obese children, thereby providing evidence that obesity-associated AT dysfunction develops in early childhood and is related to insulin resistance. | 25392242 |
| Prediabetes syndrome, Glaucoma, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes may affect vascular autoregulation of the retina and optic nerve and may be associated with an increased risk of glaucoma,but the association of prediabetes, insulin resistance, markers of glucose metabolismwith glaucoma has not beenevaluated in general population samples. | 25393836 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, diabetes mellitus, family history of coronary disease and dyslipidemia represented independent risk factors for acute myocardial infarction. | 25393858 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | It was found that more than one-third of the patients had obesity and diabetes, while 10% suffered from dyslipidemia. | 25394461 |
| Dyslipidemias, Overweight, Hyperuricemia, Prehypertension | Deregulated Nutrient Sensing | The average age, proportion of male sex, overweight, impaired fasting glucose (IFG), dyslipidaemia and hyperuricaemia were significantly higher in the prehypertension group than in the optimal BP group (all p <0.05). | 25394820 |
| Dyslipidemias, Overweight, Prehypertension | Deregulated Nutrient Sensing | Compared with low-range prehypertension, the proportions of overweight, dyslipidaemia and IFG were higher in the high-range prehypertension group (all p<0.05). | 25394820 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Ectopic hepatic lipid accumulation is closely related to the development of insulin resistance, which is regarded as one of the most significant risk factors of non-alcoholic fatty liver disease (NAFLD). | 25399407 |
| Atrial Fibrillation, Dyslipidemias, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | Among PC patients, IS (n = 190) associated with younger age, prior atrial fibrillation (AF) in 25% and dyslipidemia in ~40%. | 25402973 |
| Atrial Fibrillation, Dyslipidemias | Deregulated Nutrient Sensing | Despite being of typical age for multiple cardiovascular conditions the PC-ICH patients less often have a previous history of AF or dyslipidemia than IS patients do. | 25402973 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | To determine the clinical significance of silent mating type information regulation 2 homolog 1 (SIRT1) expression in Hepatocellular Carcinoma (HCC) and its association with P53 and Yes-associated protein 2 (YAP2) expression. | 25404446 |
| FAM126A gene | Deregulated Nutrient Sensing | Tissue microarray technique and immunohistochemistry were conducted to detect the expression of SIRT1, P53 and YAP2 proteins in 300 self-paired HCC samples. | 25404446 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | By tissue microarray technique and immunohistochemistry on 300 self-paired HCC samples, it was found that SIRT1, P53 and YAP2 were significantly overexpressed in HCC tumor tissues compared with adjacent non-tumor tissues. | 25404446 |
| Neoplasms | Deregulated Nutrient Sensing | Multivariate analysis showed nuclear SIRT1 and P53 overexpression as independent tumor promoters while cytoplasmic SIRT1 overexpression as an independent tumor suppressor. | 25404446 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1 was overexpressed in HCC and the expression was positively related to P53 and YAP2 expression. | 25404446 |
| Neoplasms, FAM126A gene | Deregulated Nutrient Sensing | As the nuclear SIRT1 functions as a tumor promoter and cytoplasmic SIRT1 functions as a tumor suppressor, the role of SIRT1 in HCC should be reconsidered. | 25404446 |
| Gestational Diabetes | Deregulated Nutrient Sensing | High calorie intake is associated with worsening insulin resistance and b-cell function in Hispanic women after gestational diabetes mellitus. | 25404660 |
| Dyslipidemias, Feeding behaviors | Deregulated Nutrient Sensing | Comorbidities were prevalent, particularly dyslipidemia and problematic eating behaviors. | 25404751 |
| Dyslipidemias, Obesity, Visceral, Somatotropin deficiency | Deregulated Nutrient Sensing | Although GHDA was associated with the development of visceral obesity and dyslipidemia, these adverse cardiovascular risk factors did not determine a higher prevalence of the MS in Bulgarian GHD patients compared to control subjects. | 25412168 |
| Liver damage, Fatty Liver Disease | Deregulated Nutrient Sensing | Orally administered anti-CD3 antibodies are biologically active in the gut through induction of regulatory T cells, exert an immune-modulatory effect, and alleviate insulin resistance and liver damage in patients with NASH. | 25412903 |
| Obesity | Deregulated Nutrient Sensing | Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance. | 25413012 |
| Overweight | Deregulated Nutrient Sensing | Circulating betatrophin levels were increased significantly in obese children and adolescents with insulin resistance (365.77 +- 30.86 pg/mL) compared with overweight or obese subjects without insulin resistance (274.25 +- 26.52 pg/mL; p < 0.05). | 25413012 |
| Fatty degeneration, Zinc deficiency | Deregulated Nutrient Sensing | Exacerbation of insulin resistance and hepatic steatosis deriving from zinc deficiency in patients with HCV-related chronic liver disease. | 25413880 |
| deficiency aspects | Deregulated Nutrient Sensing | Therefore, Zn deficiency resulted in insulin resistance through iron overload. | 25413880 |
| Steatohepatitis | Deregulated Nutrient Sensing | These data suggest that, in patients with CLD-C, Zn deficiency promotes insulin resistance by exacerbating iron overload in the liver and induces hepatic steatosis by facilitating lipid peroxidation. | 25413880 |
| ARCN1 gene, Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | The effects of Non-invasive Ventilation (NIV) on Insulin Resistance (IR) in stable Chronic Obstructive Pulmonary Disease (COPD) patients have not been fully explored. | 25415619 |
| Weight Gain, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidemia are common problems in this area and we should note to screen cardiometabolic risk factors in addition of obesity, especially in children with rapid weight gain. | 25415816 |
| Gestational Diabetes | Deregulated Nutrient Sensing | Plasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes. | 25419905 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion. | 25420343 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In the presence of insulin-resistance conditions, such as type 2 diabetes mellitus, this mechanism is altered and the glycation of cytoplasmic as well as mitochondrial proteins may plausibly appear. | 25420343 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer. | 25420528 |
| Breast Carcinoma, Malignant Neoplasms | Deregulated Nutrient Sensing | SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined. | 25420528 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The purpose of this study was to assess the possible prognostic value of SIRT1, N1IC, and Snail expression in breast cancer patients. | 25420528 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Immunohistochemistry was performed to examine the expression of SIRT1, N1IC, and Snail, and the combined expression of SIRT1 and N1IC, using tissue microarrays containing breast cancer tissue and matched adjacent normal breast tissue from 150 breast cancer patients. | 25420528 |
| Breast Carcinoma | Deregulated Nutrient Sensing | SIRT1, N1IC, and Snail were all found to be highly expressed and an inverse correlation between SIRT1 and N1IC in breast cancer tissue. | 25420528 |
| Breast Carcinoma | Deregulated Nutrient Sensing | These results suggest that low expression of SIRT1 or the combined low expression of SIRT1 and high expression of N1IC could be used as indicators of poor prognosis, and may represent novel therapeutic targets in breast cancer. | 25420528 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients carrying the E2 allele displayed protective lipid profile, while those carrying E4 appeared to be at higher risk of dyslipidemia. | 25420659 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study. | 25423564 |
| Atherosclerosis | Deregulated Nutrient Sensing | A multiethnic cohort from the Insulin Resistance Atherosclerosis Study. | 25423564 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This pattern was associated with conversion to T2D, remaining significant when accounting for b-cell function, emphasizing a link between this metabolic profile and insulin resistance. | 25423564 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These results demonstrate a consistent metabolic signature associated with insulin resistance and conversion to T2D, providing potential insight into underlying mechanisms of disease pathogenesis. | 25423564 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Obesity, Hyperandrogenism | Deregulated Nutrient Sensing | Polycystic Ovary Syndrome (PCOS) is tightly associated with insulin resistance and obesity and characterized by hyperandrogenism, chronic oligo-anovulation and polycystic ovarian morphology when fully expressed. | 25424668 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Circulating fibroblast growth factor 21 (FGF21) levels are often elevated in obesity, dyslipidaemia, insulin resistance and type 2 diabetes. | 25425220 |
| Lipolysis | Deregulated Nutrient Sensing | These FA patterns are supposed to be connected with the progression and/or impaired biochemical measures of MS (lipolysis, oxidative stress, dysglycidemia, and insulin resistance). | 25428743 |
| Sleep Apnea, CTCAE, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Sleep apnea (OR, 3.8; P <= .03) and arterial hypertension (OR, 4.1; P <= .05) were associated with stenosis severity, whereas diabetes, smoking, dyslipidemia, BMI, age, and sex were not. | 25429400 |
| Abnormal renal function | Deregulated Nutrient Sensing | Kidney dysfunction induces insulin resistance, but it is unknown if b cell function is affected. | 25429626 |
| Nonalcoholic Steatohepatitis, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic steatohepatitis (NASH) is associated with dyslipidemia and cardiovascular disease (CVD). | 25429853 |
| Dyslipidemias, Fatty Liver Disease | Deregulated Nutrient Sensing | To determine the relationship between resolution of NASH and dyslipidemia. | 25429853 |
| Dyslipidemias, Adenoma of large intestine | Deregulated Nutrient Sensing | Previous studies on the association between dyslipidemia and the presence of colorectal adenoma showed conflicting results, and were limited due to small sample sizes, inconsistent definitions of dyslipidemia, or a lack of data on full lipid profiles. | 25436347 |
| Dyslipidemias, Adenoma of large intestine | Deregulated Nutrient Sensing | The aim of this study was to determine the association between colorectal adenomas and dyslipidemia according to the definition by the National Cholesterol Education Program- Adult Treatment Panel III. | 25436347 |
| Adenoma, Dyslipidemias, Adenoma of large intestine | Deregulated Nutrient Sensing | Serum dyslipidemia profiles were compared between the adenoma group and the control group, and multivariate analysis was performed to identify independent predictors of the presence of colorectal adenomas. | 25436347 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity is a major risk factor for insulin resistance and type-2 diabetes. | 25437865 |
| Obesity | Deregulated Nutrient Sensing | A chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis. | 25437865 |
| Obesity | Deregulated Nutrient Sensing | Results from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induced-insulin resistance. | 25437865 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Taken together, these results confirm the previously established notion of chronic low grade inflammation in obesity and further suggests a role for the LT pathway in obesity-associated development of insulin resistance in humans. | 25437865 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | As risk factors, hypertension, diabetes mellitus, and dyslipidemia were much more common in patients with NSTEMI than STEMI. | 25438907 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | High FFL levels were associated with abdominal obesity, insulin resistance, and a lower live birth rate after IVF-ICSI. | 25439803 |
| Obesity | Deregulated Nutrient Sensing | Further investigations are warranted to define the precise roles of leptin, obesity, and insulin resistance on IVF-ICSI outcomes. | 25439803 |
| Cockayne Syndrome | Deregulated Nutrient Sensing | A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. | 25440059 |
| hepcidin, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated hsCRP and hepcidin levels, and increased gene expression of TNF-a, IL-6, NF-kB, and TLR-2/4 in patients with diabetes, obesity, or both exacerbate and perpetuate the insulin resistance and inflammatory state. | 25441587 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Comorbidities included hypertension (91%), dyslipidemia (87%), coronary artery disease (42%), and diabetes mellitus (38%). | 25441679 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Acanthosis nigricans in children is often a cutaneous marker of insulin resistance. | 25442473 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Spanish Interdisciplinary Committee for Cardiovascular Disease Prevention and the Spanish Society of Cardiology position statement on dyslipidemia management. | 25443815 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The Spanish Interdisciplinary Committee for Cardiovascular Disease Prevention and the Spanish Society of Cardiology reviewed this guideline and compared it with current European guidelines on cardiovascular prevention and dyslipidemia management. | 25443815 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | [Spanish Interdisciplinary Committee for Cardiovascular Disease Prevention and the Spanish Society of Cardiology position statement on dyslipidemia management. | 25444651 |
| Structure of beta Cell of islet | Deregulated Nutrient Sensing | To identify any changes in intermediate points after a 2-hour oral glucose tolerance test (OGTT), pancreatic b-cell dysfunction, and insulin resistance in cystic fibrosis-related diabetes. | 25444978 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Screening attenders had higher rates of newly diagnosed hypertension, diabetes mellitus, and dyslipidemia, lower inpatient days of stay and cost, and lower outpatient cost compared to non-attenders. | 25445334 |
| Calcification of coronary artery, Diabetes Mellitus | Deregulated Nutrient Sensing | Relationship of glycated hemoglobin A1c, coronary artery calcification and insulin resistance in males without diabetes. | 25446621 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Stratification by HbA1c showed a significant association between CAC and insulin resistance only in the first (OR 1.67) and fourth (OR 1.33) HbA1c quartile. | 25446621 |
| SLC25A20 gene | Deregulated Nutrient Sensing | After adjustment for CV risk factors, insulin resistance remained an independent predictor of CAC only in the first HbA1c quartile. | 25446621 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Our study demonstrated that not only glucose status represented by HbA1c but also insulin resistance might be associated with CAC in non-diabetic Korean men. | 25446621 |
| SLC25A20 gene | Deregulated Nutrient Sensing | The magnitude of association of CAC with insulin resistance was greater in the lowest HbA1c quartile group. | 25446621 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Persistent lipid abnormalities in statin-treated patients: Portuguese diabetic subpopulation of the Dyslipidaemia International Study (DYSIS). | 25449144 |
| Cystic Fibrosis | Deregulated Nutrient Sensing | The anti-inflammatory and immunomodulating effect of macrolides did not seem to affect the b cell function or insulin resistance in patients with cystic fibrosis. | 25450813 |
| AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A is a circulating glycoprotein capable of inhibiting insulin signaling both in vivo and in vitro and is positively associated with insulin resistance. | 25450818 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Osteoprotegerin (OPG) acts as a regulatory molecule with increased levels in the early stages of diabetes and atherosclerosis, and is also associated with insulin resistance. | 25450818 |
| Increased insulin level, Skeletal muscle structure | Deregulated Nutrient Sensing | In the present study, we hypothesized that hyperinsulinemia as an early predictor of insulin resistance may be associated with the loss of appendicular skeletal muscle mass (ASM). | 25453394 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia as an early marker of insulin resistance was associated with the loss of ASM in a cohort study of community-dwelling older men and women subjects without other chronic health conditions. | 25453394 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for cardiovascular disease that has become an increasing public health problem. | 25453396 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is especially relevant in vulnerable populations such as postmenopausal women. | 25453396 |
| Depressive disorder | Deregulated Nutrient Sensing | Association between insulin resistance and cognition in patients with depressive disorders: exploratory analyses into age-specific effects. | 25455511 |
| Angina, Unstable, Dyslipidemias | Deregulated Nutrient Sensing | Seventy patients with unstable angina pectoris and untreated dyslipidemia were randomized to either 20 mg/day or 5 mg/day of atorvastatin therapy. | 25456755 |
| Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | 54.1% of patients had dyslipidemia, 47.5% hypertension, 17.7% diabetes, and 10.8% history of ischemic heart disease. | 25459384 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Regarding drugs, despite 55% of hypertensive patients were taking>=2 antihypertensive agents, only 59.9% achieved blood pressure targets; 65.7% of patients with dyslipidemia were taking statins, but only 35.6% attained LDL-cholesterol goals. | 25459384 |
| Fatty degeneration, Diabetes Mellitus, Hepatobiliary Disorder, Obesity, Liver Cirrhosis | Deregulated Nutrient Sensing | Many patients with alcohol-associated cirrhosis also have diabetes, obesity, or insulin resistance-mediated steatosis, but little is known about how these disorders affect the severity of liver disease. | 25459558 |
| Dyslipidemias | Deregulated Nutrient Sensing | Non-HDL cholesterol (non-HDL-C) has recently been recommended as a first target for dyslipidemia management. | 25463086 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We have previously reported the combined effect of SNPs perturbing insulin signaling (ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; TRIB3 Q84R, rs2295490) on insulin resistance (IR), type 2 diabetes (T2D) and cardiovascular events. | 25463099 |
| Mortality, Premature | Deregulated Nutrient Sensing | Leprechaunism, a rare genetic disease resulting from mutations in two alleles of the insulin receptor gene, is characterized by severe insulin resistance, retarded growth and, usually, premature death. | 25465274 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The participants in this study were young; slightly overweight; had normal glucose tolerance; and had lipid values indicating dyslipidemia or close dyslipidemia. | 25466664 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Elevated plasma asymmetric dimethylarginine (ADMA) levels have been observed in patients with insulin resistance and diabetes, and have been reported to predict adverse cardiovascular events in type 2 diabetic patients. | 25467091 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE, Kidney Failure | Deregulated Nutrient Sensing | Regarding risk factors, 86% of patients had hypertension, 66% exposure to smoke, 47% diabetes, 65% dyslipidemia, 24% coronary artery disease, 16% renal failure and 60% had family history of cardiovascular disease. | 25467094 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The value of different insulin resistance indices in assessment of non-alcoholic fatty liver disease in overweight/obese children. | 25470627 |
| Alzheimers Disease", Mild cognitive disorder | Deregulated Nutrient Sensing | Amnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters. | 25471189 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Medical histories of hypertension and dyslipidemia were more frequent in the low %VC group than in the normal %VC group in both sexes. | 25477291 |
| Non-insulin Hypoglycemic, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In total, 70*5% of patients suffered from arterial hypertension, 45*2% were obese, 27*2% had non-insulin dependent diabetes, and 24*4% dyslipidaemia. | 25483380 |
| Atherosclerosis | Deregulated Nutrient Sensing | ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis. | 25484082 |
| Atherosclerosis | Deregulated Nutrient Sensing | In line with the above observations, genetic ablation of Arg2 in apoe(-/-) mice reduced RPS6KB1, enhanced PRKAA signaling and endothelial autophagy in aortas, which was associated with reduced atherosclerosis lesion formation. | 25484082 |
| Inflammation, Blood Vessel, Hypoxemia, Pre-Eclampsia | Deregulated Nutrient Sensing | Faulty placentation manifests in the mother as preeclampsia with vascular damage, enhanced systemic inflammation, and insulin resistance; in the placenta as oxygen and nutrient transfer restriction and oxidative stress; and in the fetus as growth restriction and progressive hypoxemia. | 25485869 |
| Albuminuria | Deregulated Nutrient Sensing | Elevated Lp(a) levels have a robust association with mild GFR impairment in type 2 diabetics independent of race, insulin resistance, and albuminuria. | 25490096 |
| Pancreatic hyperplasia | Deregulated Nutrient Sensing | In contrast, PGKmutBP3 mice developed insulin resistance with age in association with pancreatic b-cell hyperplasia, impaired expression of uncoupling protein-1 in BAT, and increased adiposity. | 25490144 |
| Renal Insufficiency, Hyperlipidemia, Glucose Intolerance (disease), Hypothyroidism | Deregulated Nutrient Sensing | Hypothyroidism caused impaired renal function, glucose intolerance, hyperlipidemia, and reduction in serum phosphate. | 25491211 |
| Thyroid Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and serum mineral profiles in patients with thyroid disorders. | 25491211 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Dyslipidemias may account for the excess of cardiovascular mortality in end-stage renal disease (ESRD). | 25495659 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Vitamin D and vitamin K supplementation should be considered prebariatric surgery in patients with diabetes or severe insulin resistance. | 25496224 |
| Dyslipidemias | Deregulated Nutrient Sensing | High prevalence of dyslipidemia and associated risk factors among rural Chinese adults. | 25496459 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a key independent modifiable risk factor for Cardiovascular Disease, which is a leading contributor to morbidity and mortality in most developed and developing countries. | 25496459 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of lipid abnormality (including borderline dyslipidemia and dyslipidemia) was 47.8%, 13.8%, 25.7% and 30.7% for TC, HDL-C, LDL-C and TG, respectively. | 25496459 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | We also examined various risk factors for dyslipidemia, many of which are modifiable risk factors for Cardiovascular Disease (CVD), to provide a comprehensive view that will help in designing strategies to slow the rapid spread and promote effective measures to treat dyslipidemia. | 25496459 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | To evaluate the effects of XZK on lipids in subjects with dyslipidemia but no coronary heart disease. | 25499939 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The SNP rs662 in the paraoxonase 1 gene (PON1 Q192R) has been associated with obesity, dyslipidemia and cardiovascular risk. | 25500007 |
| Dyslipidemias | Deregulated Nutrient Sensing | Polymorphisms were identified in genes selected for their role in the development of atherogenic dyslipidemia, defined as triglycerides 1.7mmol/L and high-density lipoprotein cholesterol (HDLc) <1.02 in women or 1.28mmol/L in men. | 25500319 |
| Dyslipidemias | Deregulated Nutrient Sensing | 468 patients were included, 148 of them had a diagnosis of atherogenic dyslipidemia. | 25500319 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. | 25500546 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Previous studies show that SIRT1 is overexpressed in some cancers and plays an essential role in tumorigenesis. | 25500546 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | However, the association between SIRT1 and colorectal cancer (CRC) is still unclear. | 25500546 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | We found that many CRC specimens had strong SIRT1 expression, which had an obvious correlation with poor prognosis of CRC patients. | 25500546 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Meanwhile, SIRT1 expression had a co-localization with CD133, a current universal marker to characterize colorectal cancer stem cells (CSCs). | 25500546 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Moreover, SIRT1 deficiency decreased percentage of CD133(+) cells, attenuated the abilities of colony and sphere formation, and inhibited tumorigenicity in vivo in CRC cells. | 25500546 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Further study demonstrated that the expressions of several stemness-associated genes, including Oct4, Nanog, Cripto, Tert and Lin28, were reduced by SIRT1 knockdown in CRC cells. | 25500546 |
| Colorectal Carcinoma, Neoplasms | Deregulated Nutrient Sensing | SIRT1 is a potential independent prognostic factor of CRC patients after tumor resection with curative intent, and will contribute to providing a promising new approach to target at CSCs in CRC treatment. | 25500546 |
| Inflammation | Deregulated Nutrient Sensing | These results suggest that the effect of losartan on insulin resistance is associated with the reduction of oxidative stress and inflammation in patients with type 2 DKD as well as the activation of insulin signal pathway in insulin-resistance 3T3-L1 adipocytes through modulation of PI3K pathway. | 25502581 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Almost all DFS patients had at least one vascular risk factor, with a high rate of arterial hypertension and dyslipidemia. | 25502582 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | In the cancer group, the expression level of SIRT1 was down-regulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001). | 25503141 |
| Nucleus Pulposus | Deregulated Nutrient Sensing | SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells. | 25503852 |
| Rheumatoid Arthritis, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance in rheumatoid arthritis: disease-related indicators and associations with the presence and progression of subclinical atherosclerosis. | 25504899 |
| Refractory anemias, Inflammation, Rheumatoid Arthritis, Atherosclerosis | Deregulated Nutrient Sensing | Systemic inflammation and insulin resistance (IR) are linked, yet the determinants of IR and its impact on atherosclerosis in rheumatoid arthritis (RA) are incompletely understood. | 25504899 |
| Obesity, Abdominal, Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Metabolic disturbances were found in the majority of the examinees with abdominal obesity and NAFLD; they were concurrent and increased in their rate and degree with the progression of NAFLD, obesity, and insulin resistance. | 25509888 |
| Dyslipidemias, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, metabolic disturbance | Deregulated Nutrient Sensing | The investigation has revealed that NAFLD is associated with cardiometabolic disorders (dyslipidemia, carbohydrate metabolic disturbances, and insulin resistance) increasing in their rate and degree with the progression of NAFLD and the lower adiponectin level reducing as NAFLD worsens. | 25509888 |
| Increased insulin level, Hypothyroidism | Deregulated Nutrient Sensing | The patients with hypothyroidism were found to have statistically significantly enhanced insulin resistance (IR) and compensatory hyperinsulinemia in the presence of android fat distribution. | 25509889 |
| Dyslipidemias | Deregulated Nutrient Sensing | The found atherogenic dyslipidemia manifested itself as an increase in the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and atherogenic index and as a reduction in high-density lipoprotein cholesterol. | 25509889 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Hypothyroidism is accompanied by the development of atherogenic dyslipidemia. | 25509889 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Metformin, an insulin-sensitizer, may correct several physiologic abnormalities owing to insulin resistance in patients with type 2 diabetes mellitus (DM). | 25510597 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Although the proportions of male gender, hypertension, and dyslipidemia were higher in AAA patients, such differences were not statistically significant. | 25510745 |
| Essential Hypertension, Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance is an important risk factor for cognitive impairment in elderly patients with primary hypertension. | 25510751 |
| Presenile dementia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance plays a role in the development of dementia and hypertension. | 25510751 |
| Hypertensive (finding), Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance plays an important role in the development of cognitive impairment in primary elderly hypertensive patients. | 25510751 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Upon confirmatory findings, this might help identify patient subgroups who may best benefit from the use of interventions targeting insulin resistance in well depicted breast cancer scenarios. | 25510909 |
| Hepatobiliary Disorder, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Data on demographic information, lifestyle, history of diabetes mellitus, hypertension, dyslipidemia and liver disease were collected. | 25513998 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Obese PCOS patients presented significantly more insulin resistance than nonobese PCOS patients. | 25514100 |
| Data types - Address | Deregulated Nutrient Sensing | WM improvement was inversely associated with insulin resistance (r=-0.418, p<0.01), but not with AD biomarkers. | 25516316 |
| Weight Gain | Deregulated Nutrient Sensing | The instant coffee mix that contains non-dairy creamer and/or sugar still takes up a significant portion of coffee consumption in Korea, which may result in weight gain and insulin resistance, and potential benefits of coffee may be offset. | 25516328 |
| parathyroid hormone secretion | Deregulated Nutrient Sensing | Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males. | 25517289 |
| parathyroid hormone secretion | Deregulated Nutrient Sensing | However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance. | 25517289 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Fatty liver disease, glucose tolerance and insulin resistance in obese adolescents. | 25522002 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Adult studies suggest that intra-hepatic fat predicts 2-h blood glucose levels and type 2 diabetes, and may have a role in the development of insulin resistance. | 25522002 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Enhanced tryptophan degradation, induced by the proinflammatory cytokine interferon-g, has been related to cardiovascular disease progression and insulin resistance. | 25524770 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Diet-induced obesity can induce low-level inflammation and insulin resistance. | 25526310 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Interleukin-1b (IL-1b) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. | 25526310 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our studies identify a regulatory mechanism controlling diet-induced insulin resistance by highlighting a critical role for Pellino3 in regulating IL-1b expression with implications for diseases like type 2 diabetes. | 25526310 |
| Pancreatitis, Dyslipidemias | Deregulated Nutrient Sensing | The incidence of chronic pancreatitis (CP) is increasing, and dyslipidemia severely affects the health of middle-aged and elderly people. | 25526493 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Serum sirtuin 1 levels in patients with polycystic ovary syndrome. | 25526506 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Objective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS). | 25526506 |
| Inflammation, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The sirtuin 1 level, which is associated with inflammation, the immune system and insulin metabolism, was higher in the PCOS patients than in the healthy controls. | 25526506 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Plasma calprotectin is a potential biomarker of cardiovascular disease (CVD), insulin resistance (IR), and obesity. | 25527236 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | AGEs have been associated with insulin resistance, oxidative stress, and chronic inflammation in patients with diabetes. | 25527756 |
| Cessation of life, Liver carcinoma | Deregulated Nutrient Sensing | SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway. | 25528629 |
| Cessation of life, FAM126A gene | Deregulated Nutrient Sensing | Furthermore, the human HCC cells death triggered by inhibition of SCD1 was partly involved in autophagy-induced apoptosis via AMPK signaling. | 25528629 |
| FAM126A gene | Deregulated Nutrient Sensing | Our findings reveal a novel role for SCD1 in the regulation of autophagy via AMPK signaling and provide mechanistic input for the clinical exploration that the combination of SCD1 inhibition with autophagy induction may be attractive for the management of HCC. | 25528629 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Insulin resistance and depressive symptoms in older men: the health in men study. | 25532417 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is a state of reduced responsiveness of target tissues to normal circulating levels of insulin and predisposes to diabetes in the presence of beta cell dysfunction. | 25532417 |
| Diabetes Mellitus, Bipolar Disorder | Deregulated Nutrient Sensing | We conducted this cross-sectional and prospective study in a community representative sample of 3,140 older men free of diabetes to determine if insulin resistance was associated with prevalent and incident depressive symptoms. | 25532417 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Men with insulin resistance had increased odds of depression cross-sectionally (odds ratio [OR]: 1.61; 95% confidence interval [CI]: 1.08-2.40), although this was not significant after adjustment for possible confounding (OR: 1.32; 95% CI: 0.85-2.03). | 25532417 |
| Bipolar Disorder | Deregulated Nutrient Sensing | In the longitudinal analysis, men with insulin resistance were more likely to develop clinically significant depressive symptoms (adjusted risk ratio [RR]: 2.33; 95% CI: 1.17-4.62), and this risk was greatest for men in the highest quartile of insulin resistance compared with those in the lowest quartile (adjusted RR: 2.54; 95% CI: 1.04-6.18). | 25532417 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Older men with clinically significant depressive symptoms were more likely to have higher markers of insulin resistance. | 25532417 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Additionally, the odds of depression increased with increasing levels of insulin resistance, and insulin resistance increased the risk of developing depression over 5 years later. | 25532417 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Because depression is now a leading cause of disability worldwide, addressing the rising challenge of insulin resistance may prove important in improving the future health of our communities. | 25532417 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This drug is widely used in the treatment of type 2 diabetes, where it is often referred to as an 'insulin sensitizer' because it not only lowers blood glucose, but also reduces the hyperinsulinemia associated with insulin resistance. | 25534180 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Effects of diet on adenosine monophosphate-activated protein kinase activity and disease progression in an amyotrophic lateral sclerosis model. | 25534414 |
| Heat-Shock Response, Heat-Shock Proteins 70 | Deregulated Nutrient Sensing | Activity of AMPK and phospho-AMPK, acetyl coenzyme-A carboxylase (ACC), phospho-ACC and heat shock protein-70 (Hsp70) were also measured using Western blot. | 25534414 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Inhibition of AMPK may provide a therapeutic strategy for ALS. | 25534414 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fasting insulin concentrations are increasingly being used as a surrogate for insulin resistance and risk for type 2 diabetes (T2DM), although associations with adult outcomes are unclear. | 25535261 |
| Leukemia, Myelocytic, Acute | Deregulated Nutrient Sensing | Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches. | 25537507 |
| Leukemia, Myelocytic, Acute | Deregulated Nutrient Sensing | Mounting evidence has shed light on the relevance of proteolytic systems (autophagy and ubiquitin-proteasome system, UPS), as well as the AMPK pathway, in AML biology and treatment, but their exact role is still controversial. | 25537507 |
| Dyslipidemias, Shock, Cardiogenic | Deregulated Nutrient Sensing | On multivariate analysis, dyslipidemia [0.74 (0.58-0.94), p = 0.02], vitamin K antagonists [0.55 (0.44-0.69), p < 0.001], ACEi/ARB + BB + MRA [0.56 (0.32-0.96), p = 0.04], and ACEi/ARB + BB [0.57 (0.45-0.72), p < 0.001] were associated with improved survival, conversely to cardiogenic shock [3.37 (1.90-5.98), p < 0.001], denutrition [1.61 (1.24-2.09), p < 0.001], and age over 90 [1.35 (1.09-1.67), p = 0.01]. | 25537794 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | We also observed the same pattern using insulin resistance data for categorizing abdominal obesity phenotypes. | 25540856 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) without insulin resistance: Is it different? | 25543522 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of insulin resistance [IR]. | 25543522 |
| Degenerative polyarthritis, Dyslipidemias, Heart failure, Sleep Apnea Syndromes | Deregulated Nutrient Sensing | Patient-reported treatments for comorbidities were frequent: high blood pressure, 59.1%; dyslipidaemia, 59.9%; myocardial infarction/angina pectoris, 9.7%; revascularization, 7.8%; heart failure, 7.4%; sleep apnoea, 8.3%; and osteoarthritis, 10.7%. | 25544682 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Effective management of care and medication regimens for complex patients remains an unresolved challenge, but these results suggest that medication refill adherence might be improved by minimizing the number of prescribers involved in a patient's care, at least for hypertension and dyslipidemia. | 25549627 |
| Microalbuminuria | Deregulated Nutrient Sensing | The IL-33 levels showed a serial decline with increasing severity of insulin resistance and microalbuminuria. | 25550844 |
| Cancer-related fatigue | Deregulated Nutrient Sensing | Higher 25(OH)D and CRF are crucial for reducing insulin resistance regardless of abdominal fat. | 25551248 |
| Cancer-related fatigue | Deregulated Nutrient Sensing | In addition, higher 25(OH)D concentration may strengthen the effect of CRF on reducing insulin resistance in middle-aged and elderly Japanese men with high CRF. | 25551248 |
| Dyslipidemias, Kidney Failure, Malignant Neoplasms, Diabetes Mellitus | Deregulated Nutrient Sensing | Statistically significant risk factors associated with an increased risk of malignancy after HTX were older age (P<0.0001), male recipients (P=0.0008), dyslipidemia (P=0.0263), diabetes mellitus (P=0.0003), renal insufficiency (P=0.0247), and >1 treated rejection episode (TRE) in the first year after HTX (P=0.0091). | 25552900 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Of these patients, 70.1% had hypertension, 47.1% had dyslipidemia, and 36.2% had diabetes mellitus. | 25553938 |
| Hepatitis B, Chronic, Non-alcoholic Fatty Liver Disease, Fatty degeneration, Hepatitis C, Chronic | Deregulated Nutrient Sensing | Prevalence of steatosis and insulin resistance in patients with chronic hepatitis B compared with chronic hepatitis C and non-alcoholic fatty liver disease. | 25553983 |
| Injury of liver, Fatty degeneration, Complete atrioventricular block, Non-alcoholic Fatty Liver Disease, Carcinogenic Chlorinated Hydrocarbon | Deregulated Nutrient Sensing | To investigate the prevalence and determinants of steatosis and insulin resistance (IR) in CHB and its consequences on liver injury compared with CHC and NAFLD. | 25553983 |
| Adult disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | We analyzed hormone levels of dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-I (IGF-I), which are hypothesized to be two pathways linking early growth with adult diseases (such as type 2 diabetes and cardiovascular disease) via their effects on enhanced insulin resistance. | 25555552 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | More than 50% had a history of diabetes, dyslipidaemia or hypertension. | 25556407 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21(WAF1) (/) (CIP1) ) and SIRT1 genes. | 25557355 |
| Prostate carcinoma, doxorubicin, Neoplasms | Deregulated Nutrient Sensing | Furthermore, enhancement of TLX activity, by either ectopic expression or ligand stimulation, could potently prevent doxorubicin-induced senescence in prostate cancer cells and also allow prostatic epithelial cells to escape oncogene-induced senescence induced either by activated oncogene H-Ras(G12V) or knockdown of tumour suppressor PTEN, via a mechanism of direct but differential transcriptional regulation of two senescence-associated genes, repression of CDKN1A and transactivation of SIRT1. | 25557355 |
| Obesity | Deregulated Nutrient Sensing | Cannabis use in relation to obesity and insulin resistance in the Inuit population. | 25557382 |
| Obesity | Deregulated Nutrient Sensing | To ascertain the relationship between cannabis use, obesity, and insulin resistance. | 25557382 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) genes were associated with CRC risk. | 25557790 |
| Hypertension, CTCAE, Dental Plaque, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A comparison of risk factors in specific subgroups showed that the association of lower HRV with carotid plaque was more prominent in patients with cardiovascular risk factors including male gender, hypertension, dyslipidemia and diabetes mellitus. | 25558036 |
| Hypertension, CTCAE, Comorbidity, Dyslipidemias | Deregulated Nutrient Sensing | Half of the population presented simultaneous hypertension, dyslipidemia, and DM comorbidities. | 25563032 |
| Disease | Deregulated Nutrient Sensing | A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. | 25567200 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | Finally, principal component analysis distinguished type 2 diabetic patients with and without atherogenic dyslipidemia (AD) on a second cohort of 307 subjects characterized using the Liposcale test (area under the curve = 0.88) and showed concordant relationships between variables explaining AD. | 25568061 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of fructosamine to indices of dyslipidemia in older adults with type 2 diabetes. | 25572758 |
| Dyslipidemias, Blood Glucose | Deregulated Nutrient Sensing | Fructosamine was significantly correlated with measures of dyslipidemia and glycemia both at baseline and over time, and may represent a relatively sensitive and low cost index of short to medium term change in both glycemia and certain lipid profiles. | 25572758 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In 66 patients, 47% were men, 26% had diabetes, 68% had hypertension and 76% had dyslipidemia. | 25574858 |
| Hypercholesterolemia | Deregulated Nutrient Sensing | Ezetimibe ameliorates atherogenic lipids profiles, insulin resistance and hepatocyte growth factor in obese patients with hypercholesterolemia. | 25575766 |
| Alzheimers Disease", Hypermetabolism, Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to Alzheimer disease. | 25576061 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Regarding risk factors for stroke, 260 subjects (81.0%) had hypertension, 249 subjects (77.6%) had dyslipidemia, 102 subjects (31.8%) had diabetes mellitus, 47 subjects (14.6%) had atrial fibrillation, and 98 subjects (30.5%) had chronic kidney disease. | 25576351 |
| Sepsis | Deregulated Nutrient Sensing | The increase in HMW/total adiponectin ratio with improvement of the clinical condition suggests that HMW adiponectin may have a greater role in the inflammatory process and insulin resistance seen in sepsis. | 25580089 |
| Klinefelter Syndrome, Cushing Syndrome, Secondary osteoporosis, Endocrine System Diseases, Glucose Intolerance (disease), Osteopenia | Deregulated Nutrient Sensing | It is associated with many endocrinopathies including hypogonadotropic hypogonadism, hypercortisolism, and glucose intolerance that may lead to bone loss with secondary osteoporosis. | 25580607 |
| Obesity | Deregulated Nutrient Sensing | We previously identified IKK-e and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. | 25581158 |
| Hypercholesterolemia, Hypertriglyceridemia, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia among overweight and obese children was 50.4% and its pattern was: hypertriglyceridemia 31.9%, low HDL-C 29.7%, high non-HDL-C 15.8%, hypercholesterolemia 11.9%, and elevated LDL-C 10.7%. | 25581987 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Changes in diastolic function are already present before the onset of diabetes, being mainly associated with the state of insulin resistance. | 25582424 |
| Vascular Diseases, Metabolic Syndrome X, Migraine Disorders, Cerebrovascular accident, Coronary heart disease | Deregulated Nutrient Sensing | Migraine patients present increased risks of vascular diseases such as high blood pressure, insulin resistance, metabolic syndrome, stroke and coronary heart disease. | 25585507 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia exhibit an important clinical relationship because an increase in blood lipids yields an increase in blood pressure (BP). | 25587205 |
| Hypertension, CTCAE, Dyslipidemias, Haiti | Deregulated Nutrient Sensing | These findings indicate that polymorphisms of lipid metabolism genes modify systolic BP and lipid levels and may be important in the development of essential hypertension and dyslipidemia in Mexican HT patients. | 25587205 |
| RETINOSCHISIS 1, X-LINKED, JUVENILE, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Study included 47 overweight and obese men and women with disordered glucoregulation and dyslipidaemia, aged between 45-74, divided into RS and Fibre group. | 25588971 |
| Impaired cognition, Nerve Degeneration | Deregulated Nutrient Sensing | SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1b. | 25589773 |
| Dyslipidemias, Overweight, Cardiovascular Diseases | Deregulated Nutrient Sensing | Overweight is one of the major public health problems in Brazil; it is associated with dyslipidemia, which is an important risk factor for cardiovascular diseases. | 25590927 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The results indicate an association between dyslipidemia and overweight in the population of the city of Sao Paulo. | 25590927 |
| Dyslipidemias | Deregulated Nutrient Sensing | The most prevalent dyslipidemia in this population was low HDL-cholesterol. | 25590927 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Risk factors such as hypertension (85.3%) and dyslipidemia (75.9%) were the most prevalent, with 35% of diabetics. | 25590931 |
| Dyslipidemias, Chronic disease, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Our data confirm the inverse relationship existing between pulmonary function and cardiovascular risk factors, obesity, dyslipidemias and hypertension, all of which are conditions related to chronic diseases. | 25592046 |
| Hyperglycemia | Deregulated Nutrient Sensing | DPP4 activity is an important predictor of the onset of insulin resistance and hyperglycemia in apparently healthy Chinese. | 25592717 |
| Hypertensive (finding), Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Compared with men, women were older, had lower body mass index, more likely to be hypertensive, less likely to smoke or drink alcohol, and have diabetes or dyslipidemia (p < 0.0001). | 25592794 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis. | 25592834 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | We report that abnormal localization of HuR was associated with enhanced AMP-activated protein kinase (AMPK) activity in the motor neurons of ALS patients. | 25592834 |
| Amyotrophic Lateral Sclerosis | Deregulated Nutrient Sensing | This suggests that aberrant activation of AMPK in motor neurons disrupts the normal distribution of HuR, which might imbalance RNA metabolism and contribute to ALS pathogenesis. | 25592834 |
| Metabolic Syndrome X, Diabetes Mellitus, Non-Insulin-Dependent, Prostate Cancer Outcomes Study, ETV3 wt Allele, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is associated with an increased risk of insulin resistance (IR), metabolic syndrome (MetS), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). | 25595199 |
| Obesity | Deregulated Nutrient Sensing | Nicotinamide-N-methyltransferase (NNMT) was recently shown to be upregulated in mouse models of insulin resistance and obesity. | 25596852 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We have explored the hypothesis that white adipose tissue (WAT) NNMT expression and plasma 1-methylnicotinamide (MNA) concentration are increased in human insulin resistance and type 2 diabetes. | 25596852 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We demonstrate that WAT NNMT expression is regulated in human insulin resistance and type 2 diabetes and that plasma MNA correlates with increased tissue NNMT expression and the degree of insulin resistance, making it a potential biomarker for loss of insulin sensitivity. | 25596852 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, dyslipidemia and smoking were seen in 11 (44%), 10 (40%) and 4 (16%) patients respectively. | 25604361 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance of protein metabolism occurs in obesity and type 2 diabetes (T2D). | 25604923 |
| Complication Aspects, Cushing Syndrome, Dyslipidemias, Obesity, Saint Helena Islands, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Subclinical hypercortisolism (SH) has been associated with metabolic complications such as type 2 diabetes mellitus, obesity and dyslipidemia. | 25608646 |
| Dyslipidemias, Immunoglobulin M, Saint Helena Islands, Adrenal incidentaloma, Hypertension, CTCAE | Deregulated Nutrient Sensing | In 338 patients with adrenal incidentaloma, the presence of SH, hypertension, dyslipidemia and IGM was evaluated. | 25608646 |
| Dyslipidemias | Deregulated Nutrient Sensing | The IGM+SH+ patients had a higher prevalence of dyslipidemia (57.9%) than IGM-SH+ ones (29.1%, P < 0.01). | 25608646 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The IGM+SH- patients showed an increased prevalence of hypertension (76.6 vs 54.8%, P < 0.01) and dyslipidemia (58.4 vs 23.8%, P < 0.0001) as compared with IGM-SH- patients. | 25608646 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The clinical evolution was favorable under antiretroviral treatment until 2003 when dyslipidemia and arterial hypertension appeared. | 25611282 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Coronary Artery Disease, Peripheral Vascular Diseases | Deregulated Nutrient Sensing | They had a lower prevalence of dyslipidemia, diabetes mellitus, coronary artery disease, prior myocardial infarction, and peripheral vascular disease (P < 0.001 for all). | 25611362 |
| Cessation of life, Cyclophosphamide/Vincristine/Dacarbazine Regimen, arginine | Deregulated Nutrient Sensing | We investigated non-GFR-related associations between eGFR and two types of nontraditional risk factors for CVD and death: L-arginine/dimethylarginine metabolism and insulin resistance. | 25612475 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Compared with patients without diabetes, patients with diabetes were more likely to have mixed dyslipidemia. | 25612824 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Although international guidelines highly recommend intensive lipid modulation in patients with coronary artery disease, persistent dyslipidemia is still prevalent among these patients in China, even with statin treatment. | 25612824 |
| Triglycerides | Deregulated Nutrient Sensing | Cardiometabolic abnormality was defined as the presence of at least two of the following: high blood pressure, high triglycerides, reduced high density lipoprotein cholesterol, high insulin resistance values, and elevated C-reactive protein and glucose. | 25618563 |
| Steatohepatitis | Deregulated Nutrient Sensing | Our results showed that BPA-treated rabbits showed insulin resistance, prominent adipose accumulation and hepatic steatosis. | 25619500 |
| Increased insulin level, Cardiovascular Diseases | Deregulated Nutrient Sensing | Our results show that smokers have a high risk to developing an insulin resistance and hyperinsulinemia, compared with a matched group of non-smokers, and may help to explain the high risk of cardiovascular diseases in smokers. | 25620470 |
| Renal Insufficiency, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Statin myalgia was associated with impaired muscle function, increased abdominal adiposity, whole body and leg insulin resistance, and evidence of mitochondrial dysfunction and apoptosis. | 25620655 |
| Smoking Behaviors | Deregulated Nutrient Sensing | After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance. | 25622280 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). | 25623782 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The risk factors considered were diabetes mellitus, impaired glucose tolerance, impaired fasting glucose, body mass index, dyslipidemia, and arterial hypertension. | 25624725 |
| Hypertensive (finding), Dyslipidemias, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertensive patients were older and had a higher prevalence of major risk factors, including smoking, obesity, dyslipidemia, and family history of cardiovascular disease, as well as comorbidities, than did normotensive subjects (P < 0.001 for all comparisons). | 25626397 |
| Dyslipidemias, ETV3 wt Allele | Deregulated Nutrient Sensing | The prevalence of MetS increased with higher QTSH within the euthyroid range, mostly by an increase in the dyslipidemia. | 25627048 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | While both pharmacological and genetic suppression of autophagy or inhibition of AMPK phosphorylation sensitized the NSCLC cells to radiation alone, inhibition of the cytostatic autophagy induced by the combination treatment reversed sensitization. | 25629933 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Taken together, these studies have identified a unique cytostatic function of autophagy that appears to be mediated by VDR, TP53, and possibly AMPK in the promotion of an enhanced response to radiation by 1,25-D3 and EB 1089 in NSCLC. | 25629933 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | This ratio was maintained after adjusting for age, sex, hypertension, dyslipidaemia, cardioembolic focus, smoking, diabetes, other cardiovascular diseases, C-reactive protein, and leukocyte count (OR 2.6, 95% CI 1.3 to 5.3). | 25630457 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Interesting epidemiological evidence suggests associations between Ps and dyslipidemia (DL), a well-established risk factor for cardiovascular disease. | 25634083 |
| Arterial Stiffness, Hyperglycemia, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The non-hemodynamic cluster of risk markers and predictors of arterial stiffness in a middle-aged population includes abdominal obesity, hyperglycemia, and dyslipidemia, but not smoking and low-density lipoprotein cholesterol. | 25634451 |
| Peripheral Vascular Diseases, Carotid Stenosis, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Coronary artery disease/peripheral vascular disease (CAD/PVD) (p=0.03), dyslipidemia (p=0.02), CKD (p=0.01), and contralateral internal carotid artery stenosis (p=0.02) were non-modifiable risk factors for mRS increase. | 25635402 |
| TG gene | Deregulated Nutrient Sensing | To explore the association of lipid ratios and triglyceride (TG) with insulin resistance (IR) in a Chinese population. | 25635876 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | In men, lower T levels, but not E2, are linked with an increased risk of developing MetS, independent of SHBG, BMI or insulin resistance. | 25636052 |
| Polycystic Ovary Syndrome, Hyperandrogenism | Deregulated Nutrient Sensing | Insulin resistance and hyperandrogenism have no substantive association with birth weight in adolescents with polycystic ovary syndrome. | 25637475 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | The birth weights of adolescents with PCOS as well as those with hyperinsulinemic or insulin resistance were similar to those of the control group. | 25637475 |
| Prostate Cancer Outcomes Study, Hyperandrogenism | Deregulated Nutrient Sensing | Low birth weight may influence the appearance of hyperandrogenism and insulin resistance in a portion of adolescents with PCOS, but only 9% of the adolescents with PCOS in this study were SGA. | 25637475 |
| diabetic | Deregulated Nutrient Sensing | Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients. | 25641023 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | There is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes. | 25644349 |
| millicurie, Data types - Address | Deregulated Nutrient Sensing | Both AD and MCI subjects showed increased, insulin receptor substrate 1, a candidate biomarker of brain insulin resistance, and GSK-3b, a kinase targeting tau phosphorylation. | 25645581 |
| Data types - Address | Deregulated Nutrient Sensing | The results hint at a link between Ab and the PI3K/Akt/mTOR axis and provide further insights into the relationship between AD pathology and insulin resistance. | 25645581 |
| Inflammation, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Previous studies reported beneficial effects of cocoa or chocolate on insulin resistance, oxidative stress, and inflammation, which are important risk factors of type 2 diabetes mellitus (DM). | 25646334 |
| Atherosclerosis | Deregulated Nutrient Sensing | Visceral fat contributes to insulin resistance and atherosclerosis. | 25648643 |
| Blood Glucose | Deregulated Nutrient Sensing | The effect of this treatment on glycemia, insulin secretion and insulin resistance was investigated. | 25649338 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population. | 25649924 |
| Increased insulin level, Prediabetes syndrome | Deregulated Nutrient Sensing | Moreover, the risks for prevalent prediabetes, insulin resistance, and hyperinsulinemia were also decreased from the lowest to the top quartile. | 25649924 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | According to the present study, one session of aerobic exercise for middle-aged men with T2D leads to increased IGF-1 and IGFBP-3, and to decreased fasting glucose and insulin resistance. | 25650732 |
| Obesity | Deregulated Nutrient Sensing | In addition, it has been reported that black soybean (BS) seed coat may ameliorate obesity and insulin resistance. | 25651043 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview. | 25655678 |
| Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Among diabetics, higher NLR tertile values were related to ageing (P<0.001), dyslipidaemia (P<0.001), renal failure (P<0.001), body mass index (P<0.001), previous percutaneous coronary revascularization (P=0.004) and cerebrovascular events (P=0.003), acute presentation (P<0.001), treatment at admission with beta-blockers/statins/ASA (all P<0.001), diuretics (P=0.01) or clopidogrel (P=0.04), platelet count (P=0.03), white blood cell count, creatinine, glycaemia and C-reactive protein (P<0.001), and inversely related to haemoglobin, triglyceride levels (P<0.001) and smoking (P=0.03). | 25656745 |
| Sepsis | Deregulated Nutrient Sensing | Sirt1 restrains lung inflammasome activation in a murine model of sepsis. | 25659903 |
| Inflammatory | Deregulated Nutrient Sensing | Our results demonstrated that Sirt1 deficiency led to severe lung inflammatory injury. | 25659903 |
| lung induction | Deregulated Nutrient Sensing | Aggravated inflammasome activation in Sirt1(-/-) mice was associated with the increased production of lung proinflammatory mediators, including ICAM-1 and high-mobility group box 1, and further disruption of tight junctions and adherens junctions, as demonstrated by dramatic reduction of lung claudin-1 and vascular endothelial-cadherin expression, which was associated with the upregulation of matrix metallopeptidase 9 expression. | 25659903 |
| Sepsis, Pneumonitis | Deregulated Nutrient Sensing | In summary, our results suggest that Sirt1 suppresses acute lung inflammation during sepsis by controlling inflammasome activation pathway. | 25659903 |
| Cataract | Deregulated Nutrient Sensing | Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract. | 25660075 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Today, the frequency of dyslipidemia, hypertension and diabetes mellitus has increased, while smoking has decreased. | 25660087 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension prevalence was 62.3%, for diabetes mellitus it was 48.8%, for smoking it was 18.8% and for dyslipidemia it was 48.8%. | 25660087 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Decade | Deregulated Nutrient Sensing | We observed an increase in prevalence for diabetes mellitus and dyslipidemia in each cohort according to birth decade, while there was a reduction in prevalence for hypertension in the same decades. | 25660087 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Studies were conducted in 28 patients with type 2 diabetes mellitus complicated with dyslipidemia. | 25660177 |
| Dyslipidemias | Deregulated Nutrient Sensing | A double-blind, randomized, placebo-controlled parallel-group trial (the DALI study group) on 217 patients with T2DM and dyslipidemia was performed. | 25662039 |
| Coronary heart disease | Deregulated Nutrient Sensing | Given the many syndromes associated with insulin resistance, including T2DM and coronary heart disease, an elevated TG/HDL-C ratio supports more aggressive efforts to enhance insulin sensitivity. | 25667373 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Recent studies suggest the potential involvement of environmental chemicals in insulin resistance (IR) that plays a core role in the development of metabolic diseases. | 25669219 |
| Obesity | Deregulated Nutrient Sensing | Visfatin/Nampt and SIRT1: Roles in Postterm Delivery in Pregnancies Associated With Obesity. | 25670718 |
| Obesity | Deregulated Nutrient Sensing | Thus, higher visfatin/Nampt may prevent a labor-associated decrease in SIRT1 leading to postterm delivery in obesity. | 25670718 |
| Atherosclerosis | Deregulated Nutrient Sensing | Comparison between insulin resistance indices and carotid and femoral atherosclerosis: a cross-sectional population study. | 25673308 |
| Atherosclerosis | Deregulated Nutrient Sensing | The aim of this study was to investigate the association between commonly used insulin resistance (IR) indices and the presence and extent of carotid and femoral atherosclerosis in a general population setting. | 25673308 |
| Migraine Disorders, Dyslipidemias | Deregulated Nutrient Sensing | In the opposite direction, a positive association between migraine headaches (definite, probable and overall) and dyslipidemia (overall migraine OR, 1.25; 95% CI, 1.13-1.38) was observed only for women, but not for men. | 25673421 |
| Peripheral T-Cell Lymphoma | Deregulated Nutrient Sensing | Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-kB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options. | 25674239 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Approximately 6% were women, 21% were highly disabled from a military service-connected condition, 46% had hypertension, 38% dyslipidemia, and 18% diabetes. | 25674731 |
| deficiency aspects | Deregulated Nutrient Sensing | Because of the severity of the insulin resistance combined with features of insulin deficiency, type B insulin resistance was suspected. | 25675382 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The major modifiable risk factors are smoking, hypertension, dyslipidaemia, diabetes, and obesity. | 25675643 |
| Kidney Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | Two major causes of diabetes are insulin resistance and insulin insufficiency. | 25676679 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance is considered a pathophysiological mechanism of nonalcoholic fatty liver disease (NAFLD). | 25677815 |
| Increase in blood pressure, Dyslipidemias, Retinal Diseases, Aortic Stiffness | Deregulated Nutrient Sensing | Other independent correlates of progression in aortic stiffness were increases in systolic blood pressure and heart rate between the two cf-PWV measurements, older age, female sex, and presence of dyslipidemia and retinopathy. | 25678104 |
| Acute leukemia, Dyslipidemias, leukemia | Deregulated Nutrient Sensing | These findings may help in outlining the prevalence and types of dyslipidemia in leukemia patients that may emerge as diagnostic/prognostic factors for the management of acute leukemia. | 25680744 |
| leukemia | Deregulated Nutrient Sensing | In addition to comparing the absolute values of plasma lipids in leukemia and control groups we also compared and observed significant differences in prevalence of various isolated- and mixed-dyslipidemias in these groups. | 25680744 |
| Fibrosis Assessment, Obesity, Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance, obesity, and the presence of either of 2 minor alleles in the PNPLA3 gene were significantly associated with increased risk of NASH and fibrosis. | 25681381 |
| TG gene, Increased insulin level | Deregulated Nutrient Sensing | Despite similar fasting glucose and HbA1c concentrations, patients with elevated TG concentrations displayed markers of increased risk of T2DM (insulin resistance and compensatory hyperinsulinemia), more adverse lipid/lipoprotein profiles, and increased prevalence of abnormal hs-CRP values. | 25682039 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Odds of overweight/obesity, abdominal obesity and insulin resistance were greater among higher SES. | 25691273 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Compared with the lowest SES stratum, children in the highest SES had higher odds of overweight/obesity (OR=3.25, 95% CI 1.89 to 5.57), abdominal obesity (OR=2.74, 95% CI 1.41 to 5.31) and insulin resistance (OR=2.60, 95% CI 1.81 to 3.71). | 25691273 |
| Hypertriglyceridemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In Colombian children, SES is directly associated with obesity and insulin resistance, but inversely associated with dyslipidaemia (hypertriglyceridaemia and low HDL cholesterol). | 25691273 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | To analyse the treatment and control of dyslipidaemia in patients at high and very high cardiovascular risk being treated for the primary prevention of cardiovascular disease (CVD) in Europe. | 25692692 |
| Cholangiocarcinoma, Liver carcinoma | Deregulated Nutrient Sensing | Differential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver. | 25696003 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | Gene expression and deacetylase activity of the class III histone deacetylase SIRT1 are up-regulated in cancer cells due to oncogene overexpression or loss of function of tumor suppressor genes. | 25696003 |
| Neoplasms, Malignant Neoplasms | Deregulated Nutrient Sensing | SIRT1 may play a critical role in tumor initiation, progression, and drug resistance by blocking senescence and apoptosis, and promoting cell growth and angiogenesis, but pleiotropic effects (synchronous or metachronous anti-proliferation and anti-apoptotic mechanisms) have been suggested in some cancers. | 25696003 |
| FBN2 wt Allele, FAM126A gene | Deregulated Nutrient Sensing | Western blot analysis (WBA) was carried out for expression of SIRT1 in three CCA cell lines, one HCC cell line, and one cell line of Papova-immortalized normal hepatocytes. | 25696003 |
| FBN2 wt Allele, FAM126A gene | Deregulated Nutrient Sensing | An expression of SIRT1 was found in 11 of 16 (68.75%) HCC and in 5 of 14 (35.71%) CCA. | 25696003 |
| FAM126A gene | Deregulated Nutrient Sensing | WBA showed expression of SIRT1 in all cell lines studied, although a stronger signal was seen in the HCC cell line. | 25696003 |
| FBN2 wt Allele, FAM126A gene | Deregulated Nutrient Sensing | Sirtuin 1 is a phylogenetically-conserved family of deacetylases and our data seem to indicate that (1) pleiotropic effects may be present in hepatic epithelial malignancies, and (2) there is no specificity of SIRT1 for either HCC or CCA. | 25696003 |
| Dyslipidemias, Hypomagnesemia, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hypomagnesemia and atherogenic dyslipidemia in chronic kidney disease: surrogate markers for increased cardiovascular risk. | 25697595 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | We also observed a significant correlation between the lowered serum magnesium concentrations and atherogenic dyslipidemia, suggesting a link to increased cardiovascular risk in CKD patients. | 25697595 |
| Dyslipidemias, Hypomagnesemia, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Our results suggest a strong association of hypomagnesemia and atherogenic dyslipidemia in patients with CKD. | 25697595 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways. | 25701120 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The mammalian target of rapamycin complex 1 (mTORC1) is a downstream of the PI3K/Akt pathway which affects cancer development. | 25701120 |
| Breast Carcinoma | Deregulated Nutrient Sensing | This study aims to investigate the expression of mTORC1 in breast cancer (BC) and correlate it with key clinicopathological and molecular features of BC especially to proteins related to oestrogen receptor (ER) and HER2 pathways in different BC classes. | 25701120 |
| Neoplasms | Deregulated Nutrient Sensing | RPPA indicated that p-mTORC1 expression was mainly related to ER expression and with better outcome in the Akt positive tumours. | 25701120 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Taken together, we concluded that DDAH2/ADMA is involved in the accelerated senescence of EPCs in diabetes, which is associated with the activation of SIRT1. | 25701782 |
| Tobacco, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The other associated risk factors were sedentariness in 275 cases (44.4%), overweight/obesity in 134 cases (21.6%), dyslipidemia in 121 cases (19.5%), diabetes mellitus in 90 cases (14.5%), and tobacco addiction in 25 cases (4%). | 25702238 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Acute ischemic stroke patients with dyslipidemia and AAPs >=4-mm-thick on transesophageal echocardiography (TEE) were enrolled and randomly allocated to either the group treated with 5 mg/day rosuvastatin or the control group. | 25702618 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Human liver PPARa gene expression negatively correlates with NASH severity, visceral adiposity and insulin resistance and positively with adiponectin. | 25703085 |
| Hyperlipidemia, Dyslipidemias, Ischemic | Deregulated Nutrient Sensing | Additional predictors were low body mass index, male gender, ischaemic HF, low total cholesterol, no history of hyperlipidaemia or dyslipidaemia and presence of atrial fibrillation/flutter. | 25703424 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | Adiponectin mediates antiproliferative and apoptotic responses in endometrial carcinoma by the AdipoRs/AMPK pathway. | 25703675 |
| Hypertension, CTCAE, Premature coronary artery atherosclerosis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among the 428 patients, 184 (43%) cases had hypertension, 133 (31%) cases were smokers, 103 (24%) cases had dyslipidemia and diabetes mellitus and 08 (2%) cases had history of premature coronary artery disease. | 25703749 |
| Blood Vessel | Deregulated Nutrient Sensing | Since pigment epithelium-derived factor (PEDF), one of the adipocytokines, inhibits the AGEs-induced insulin resistance and vascular damage, it is conceivable that besides AGEs, PEDF might also regulate soluble DPP-4 levels. | 25705004 |
| Encounter due to puberty, Obesity | Deregulated Nutrient Sensing | The data showed changes in DEHP metabolites in urine related with obesity, puberty, and presence of insulin resistance. | 25706863 |
| Lipodystrophy, Metabolic Syndrome X | Deregulated Nutrient Sensing | This cohort study shows how the synergy between HIV, antiretroviral (ARV) exposure, and westernization of life style in a cohort of HIV-infected patients of sub-Saharan origin leads to a progressive increase in the risk of lipodystrophy, as well as metabolic syndrome and insulin resistance, all associated with increased cardiovascular risk. | 25707418 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Android Adiposity and Lack of Moderate and Vigorous Physical Activity Are Associated With Insulin Resistance and Diabetes in Aging Adults. | 25711528 |
| Albuminuria | Deregulated Nutrient Sensing | After adjustment for age, gender, race, smoking, blood pressure, insulin resistance, and body mass index, individuals with less liver fat (higher liver CT attenuation) had a lower probability of having albuminuria at Exam 1 (OR per 10 unit increase in attenuation 0.77, 95 % CI 0.61-0.97, P = 0.02). | 25712234 |
| Inflammation, Primary malignant neoplasm, Hypoxia | Deregulated Nutrient Sensing | Excess visceral adipose tissue may promote cancer development and progression via an obesity-related metabolic derangements, including adipocytokine-related inflammation, insulin resistance, and hypoxia. | 25712800 |
| Dyslipidemias | Deregulated Nutrient Sensing | Non-traumatic maneuver of left IMA harvest, well-controlled dyslipidemia and avoidance of using composite grafts can be helpful in maintaining the architecture of the grafts. | 25714207 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The usefulness of a cholesterol absorption inhibitor in Japanese type 2 diabetes patients with dyslipidemia. | 25714444 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We studied the clinical efficacy of ezetimibe in Japanese patients with type 2 diabetes mellitus complicated by dyslipidemia, in whom increased cholesterol absorption had been reported. | 25714444 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Ninety-six patients with type 2 diabetes complicated by dyslipidemia received ezetimibe at 10 mg/day for 12 weeks. | 25714444 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | It is suggested that ezetimibe improves the lipid profile in Japanese type 2 diabetes patients with dyslipidemia through the substantial reduction of cholesterol absorption. | 25714444 |
| Obesity | Deregulated Nutrient Sensing | Oxidative stress has been implicated in the pathogenesis of many conditions, including insulin resistance and obesity. | 25714911 |
| Obesity | Deregulated Nutrient Sensing | Central obesity was independently associated with oxidative stress even in a population homogeneous for adiposity and cardiometabolic risk, whereas no relationship was observed between oxidative stress and insulin resistance. | 25714911 |
| Ischemic | Deregulated Nutrient Sensing | The loss of effectiveness of ischaemic preconditioning in protecting old hearts from ischaemia/reperfusion damage is thought to be due to low sirtuin 1 levels in old hearts. | 25715432 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | In addition, even in non-overweight/non-obese men, DT was found to be related to dyslipidemia and hyperglycemia, though with marginal significance (P < 0.05). | 25716056 |
| APP gene, Dyslipidemias | Deregulated Nutrient Sensing | The aim of the study was to define the role of CIDE-A gene in patients with dyslipidemia and asymptomatic AAA. | 25720106 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | No relationship was found between osteocalcin and insulin resistance and lipid metabolism in type 2 diabetes. | 25721846 |
| Fatty Liver, Inflammation, Metabolic Diseases, Obesity | Deregulated Nutrient Sensing | Obesity is a major risk factor for many chronic metabolic diseases such as inflammation, insulin resistance (IR) and fatty liver injury. | 25723054 |
| FTO protein, human | Deregulated Nutrient Sensing | These changes contribute to the development of insulin resistance and obesity-associated diseases. | 25724478 |
| Glucose Intolerance (disease), Autonomic nervous system disorders | Deregulated Nutrient Sensing | Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey. | 25724570 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | We aimed to determine the prevalence of, risk factors for and impact of CAND in glucose intolerance and diabetes. | 25724570 |
| Obesity | Deregulated Nutrient Sensing | Obesity in children is now an increasing health risk worldwide in which the insulin-resistance can be present. | 25726199 |
| Arthropathy, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Disease | Deregulated Nutrient Sensing | All patients has diseases associated with obesity, the most frequent of which were arterial hypertension (n = 16), arthropathy (n = 11), dyslipidemia (n = 9) and diabetes (n = 7). | 25726230 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Current recommendations on treatment of dyslipidemia should be applied with caution in the HIV infected population. | 25727038 |
| Tumor necrosis, Obesity | Deregulated Nutrient Sensing | Tumor necrosis factor-a (TNF-a) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. | 25729992 |
| Hypercholesterolemia, Dyslipidemias, Chronic disease | Deregulated Nutrient Sensing | Similar to its existing use in the diagnosis of monogenic dyslipidemias such as familial hypercholesterolemia, clinical inquiry regarding family history was identified as an important determinant of eligibility for APOE genotyping performed in the context of chronic disease risk management. | 25731628 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Impaired insulin resistance might precede the clinical detection of this cancer by several years. | 25734801 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Inflammation but not obesity or insulin resistance is associated with increased plasma fibroblast growth factor 23 concentration in the elderly. | 25736796 |
| Obesity | Deregulated Nutrient Sensing | Both forms of FGF23, iPTH and 25-OH-D3 levels were not related to the occurrence of obesity and insulin resistance. | 25736796 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | In conclusion, our study shows that increased levels of both circulating Fibroblast growth factor 23 forms in elderly subjects are associated with inflammation but not obesity or insulin resistance per se. | 25736796 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Adjusted for other risk factors, being male, older age, higher relative socio-economic disadvantage, being born in Asia, lower educational attainment, medical history of hypertension and dyslipidemia, family history of T2DM, overweight/obese, smoking, long sleeping hours, and psychological distress were significantly associated with higher odds of developing T2DM. | 25737033 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | However, the roles of AMPK in the pathogenesis of Alzheimer's disease (AD) are unclear. | 25737046 |
| Data types - Address | Deregulated Nutrient Sensing | Taken together, our data showed that AMPK activation inhibits p-tau396 expression in a GSK3b- and PP2A-dependent manner, and suggest that differential regulation of tau phosphorylation in young SAMP8 mice by AMPK plays a compensatory role against accelerated senescence in this AD animal model. | 25737046 |
| Obesity | Deregulated Nutrient Sensing | MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity. | 25738459 |
| Obesity | Deregulated Nutrient Sensing | When adjusted for age, gender and pubertal development, higher degree of obesity was a strong predictor of MS. Multivariate analysis showed that taller subjects and those with higher degree of insulin resistance were at significantly higher risk of MS, independent of the degree of obesity. | 25741939 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These data demonstrate that the STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis. | 25747354 |
| Asthma, Metabolic Syndrome X, MS gene, Obesity | Deregulated Nutrient Sensing | Obesity increases both the risk of asthma and asthma severity and is a well-known risk factor for insulin resistance and the metabolic syndrome (MS) in children and adolescents. | 25748066 |
| Obesity | Deregulated Nutrient Sensing | Asthma and MS synergistically decrease lung function, as do obesity and insulin resistance. | 25748066 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | The 420 patients in the study had one or more NCDs such as hypertension, type 2 diabetes mellitus, and dyslipidemia. | 25751416 |
| Dyslipidemias, ciliary vesicle, Diabetes Mellitus | Deregulated Nutrient Sensing | We recorded diabetes mellitus in 136 patients (20.8%), history of CV disease in 213 (32.6%) and dyslipidaemia in 327 (50.1%). | 25753805 |
| Dyslipidemias | Deregulated Nutrient Sensing | Therefore, the determinants for achieving the LDL-C target needed to be clarified for better healthcare of the patients with dyslipidemia. | 25756522 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | There is a growing awareness that lifestyle behavior modifications may reduce weight and the atherogenic dyslipidemia associated with obesity and type 2 diabetes mellitus (T2DM). | 25757855 |
| hypothalamic-pituitary-adrenal axis, Depression, CTCAE | Deregulated Nutrient Sensing | Relationship between hypothalamic-pituitary-adrenal axis dysregulation and insulin resistance in elderly patients with depression. | 25757913 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Furthermore, insulin resistance and the prevalence of type 2 diabetes are known to increase with aging. | 25757913 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, an indicator of atherogenic dyslipidemia, is a predictor of cardiovascular (CV) outcomes in the general population and has been correlated with atherosclerotic events. | 25761189 |
| Obesity | Deregulated Nutrient Sensing | The common variants in the fat mass and obesity-associated (FTO) gene have been associated with obesity and insulin resistance. | 25761503 |
| Dyslipidemias, Demographics Domain, Myocardial Ischemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Markers of CVD risk in 65 LTRs with no known history of diabetes mellitus (DM), dyslipidemia, or ischemic heart disease were compared to age-, sex-, and body mass index (BMI)-matched controls with no chronic medical disease. | 25762084 |
| Dyslipidemias | Deregulated Nutrient Sensing | Results highlight that inherited susceptibilities to dyslipidemia may explain at least in part the heterogeneity in the cholesterol-lowering effects of the MedDiet. | 25766081 |
| Cardiotoxicity | Deregulated Nutrient Sensing | SIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways. | 25766524 |
| Heart failure | Deregulated Nutrient Sensing | We analyzed SIRT1 expression in doxorubicin-induced neonatal rat cardiomyocyte injury model and adult mouse heart failure model. | 25766524 |
| Heart failure | Deregulated Nutrient Sensing | SIRT1 agonist resveratrol was used to treat the doxorubicin-induced heart failure mouse model. | 25766524 |
| Cardiac function | Deregulated Nutrient Sensing | The SIRT1 agonist resveratrol was able to prevent doxorubicin-induced heart function loss. | 25766524 |
| Heart Injuries, Cardiomyopathies | Deregulated Nutrient Sensing | These results support the role of SIRT1 as an important regulator of cardiomyocyte apoptosis during doxorubicin-induced heart injury, which may represent a potential therapeutic target for doxorubicin-induced cardiomyopathy. | 25766524 |
| Obesity | Deregulated Nutrient Sensing | BP was sensitively dependent on insulin resistance and lipid accumulation in all subjects; however, sodium intake may be an independent risk factor of obesity without increasing BP in girls. | 25768006 |
| Coronary Arteriosclerosis | Deregulated Nutrient Sensing | Lower AMP-activated protein kinase level is associated with the vulnerability of coronary atherosclerotic plaques by attenuating the expression of monocyte autophagy. | 25768243 |
| atherosclerotic | Deregulated Nutrient Sensing | However, research on the relationship between AMP-activated protein kinase (AMPK) and vulnerable atherosclerotic plaques is still insufficient. | 25768243 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | The level of phosphorylated AMPK was significantly decreased in patients with acute coronary syndrome compared with those in the SAP and control groups (P<0.01). | 25768243 |
| Rupture, Dental Plaque | Deregulated Nutrient Sensing | Therefore, our work is novel in showing that AMPK of PBMs may decrease plaque vulnerability and subsequent plaque rupture through activation of autophagy. | 25768243 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Dysautonomia, Familial, Hyperlipoproteinemia Type III, Hyperlipoproteinemias | Deregulated Nutrient Sensing | Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). | 25768710 |
| Steatohepatitis, Halotestin, HIV-Associated Lipodystrophy Syndrome | Deregulated Nutrient Sensing | HIV-infected patients frequently develop HIV and highly active antiretroviral treatment-associated lipodystrophy syndrome (HALS), characterized by accumulation of intra-abdominal fat, insulin resistance, and hepatic steatosis. | 25769096 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with dyslipidemia displayed greater amounts of lipid and calcium than those with normal lipid levels. | 25769575 |
| Dyslipidemias | Deregulated Nutrient Sensing | In patients with dyslipidemia, calcium intake was lower than those in patients without dyslipidemia, although their intake of lipids was also lower than those without dyslipidemia. | 25769575 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Symmetric dimethylarginine (SDMA) serum levels in rheumatoid arthritis: correlations with insulin resistance and disease activity scores. | 25772817 |
| Refractory anemias, Atherosclerosis | Deregulated Nutrient Sensing | The molecular explanation of lower serum SDMA is unclear, but the established relationships with indices of disease activity and insulin resistance, may underline the pathogenetic role of the L-arginine/NO pathway dysregulation in the development of atherosclerosis in RA. | 25772817 |
| Hypoadiponectinemia, Obesity | Deregulated Nutrient Sensing | Insulin resistance and central obesity have been implicated in the pathogenesis of hypoadiponectinemia in obesity. | 25774471 |
| Dyslipidemias | Deregulated Nutrient Sensing | Traditionally, the high prevalence of dyslipidemia in elderly people is considered a "natural condition." | 25780934 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Notably, subclinical hypothyroidism (SCH) is one of the most important risk factors for dyslipidemia. | 25780934 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Lower levels of fasting GLP-1 and impaired glucagon suppression in adult offspring exposed to maternal diabetes during pregnancy are diabetogenic traits that may contribute to glucose intolerance in these persons, but further investigations are needed. | 25781355 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Emerging on the grounds of obesity, IR confers risks for dyslipidemia and hypertension at a relatively early age. | 25781532 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of hypertension, dyslipidemia and diabetes was higher with increased WHtR for both ethnic groups after adjusted by age. | 25782420 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | NAFLD is closely associated with insulin resistance (IR), and although the role of IR in NAFLD has been an area of intense investigation, there are limited data on pancreatic b-cell function. | 25784075 |
| Hepatobiliary Disorder, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Medical records were reviewed for the presence of diabetes, body mass index, diabetes treatment, and comorbidities at the time of biopsy (eg, underlying liver disease, hypertension, dyslipidemia). | 25786083 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Diabetic patients had a higher average body mass index (33 vs. 30 m/kg, P=0.0039), prevalence of hypertension (78% vs. 33%, P<0.0001), and dyslipidemia (52% vs. 20%, P<0.0001). | 25786083 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | The AA genotype might be associated with the development of dyslipidemia in ACS patients. | 25788758 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Dyslipidemia is one of the most important risk factors for coronary artery disease (CAD), and low-densitylipoprotein cholesterol (LDL-C) is used to measure dyslipidemia. | 25790545 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | The increase in overweight and obese children may be linked to increased rates of dyslipidaemia. | 25793380 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | The most common dyslipidaemia was high TG in combination (26.2%) and in isolation (10.6%). | 25793380 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | A high TG level was the most frequent dyslipidaemia. | 25793380 |
| Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | Magnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance. | 25793876 |
| physiopathological | Deregulated Nutrient Sensing | Both in vitro and in vivo experiments were designed to test the role of AMP-activated protein kinase (AMPK) in LPS-induced BBB dysfunction. | 25794165 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The same genetic variant (major allele of rs2431332) was also significantly associated with higher plasma insulin (P = 0.019), increased HOMA insulin resistance (P = 0.019), and an increased risk of incident diabetes (P = 0.001) in the pooled analysis of the discovery cohort together with the two replication cohorts (n = 20,698 and n = 7,995). | 25795213 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | [Erythrocyte aggregation in patients with arterial hypertension and dyslipidemia treated with pravastatin]. | 25796944 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The study demonstrated increased erythrocyte aggregation in patients with arterial hypertension and dyslipidemia, abnormal blood lipid spectrum and lipid composition of erythrocyte membranes, activation of lipid peroxidation. | 25796944 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Correlated analysis and pathological study on insulin resistance and cardiovascular endocrine hormone in elderly hypertension patients. | 25796973 |
| Hypertensive (finding), Hypertension, CTCAE | Deregulated Nutrient Sensing | This study has shown that there is a significant correlation and pathological effect between insulin resistance and cardiovascular endocrine hormone in hypertensive patients, and which plays an important role in genesis and development of hypertension in elderly people. | 25796973 |
| Pancreatic Ductal Adenocarcinoma | Deregulated Nutrient Sensing | SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation. | 25798752 |
| Neoplasms | Deregulated Nutrient Sensing | Having adjusted for age, adjuvant therapy and tumor stage, we evidenced that patients with higher PER2 and lower SIRT1 expression levels showed lower mortality (p = 0.028). | 25798752 |
| Carcinogenesis, Primary malignant neoplasm | Deregulated Nutrient Sensing | In conclusion, a severe deregulation of expression of SIRT1 and circadian genes was evidenced in the cancer specimens of PC patients, and starvation influenced gene expression in PC cell lines, suggesting that the altered interplay between SIRT1 and the core circadian proteins could represent a crucial player in the process of pancreatic carcinogenesis. | 25798752 |
| Inflammation, Cushing Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome. | 25799396 |
| Dyslipidemias, Left ventricular ejection fraction, Diabetes Mellitus | Deregulated Nutrient Sensing | There were more patients with diabetes mellitus (38.8%), dyslipidemia (86.1%) and patients with low left ventricular ejection fraction (50%). | 25802449 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hence age, diabetes mellitus, dyslipidemia, left ventricular ejection fraction <40%, number of damaged coronaries might be considered as predictors of CK-MB elevation after successful PCI. | 25802449 |
| Insulin Resistance, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Gut microbiota influence metabolic pathways related to the pathogenesis of obesity, insulin-resistance and diabetes. | 25805893 |
| Inflammation, CER tumor staging notation | Deregulated Nutrient Sensing | The underlying factor could be accumulation of certain lipid moieties, such as ceramides (CER) and diacylgycerol (DAG) within muscle tissue, which are known to promote insulin resistance (IR), induce inflammation and oxidative injury, ultimately altering muscle function. | 25809802 |
| Glucose Intolerance (disease), Obesity, Abdominal | Deregulated Nutrient Sensing | An association was found between accumulation of specific ceramide species in muscle tissue and abdominal obesity, glucose intolerance and shortening of leukocyte telomeres, although not with muscle oxidative injury or dysfunction. | 25809802 |
| Islets of Langerhans hyperplasia | Deregulated Nutrient Sensing | Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. | 25811804 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Fibroblast growth factor (FGF) 21 is an endocrine factor that normalizes glucose homeostasis and reduces insulin resistance in diabetes. | 25811804 |
| physiopathological | Deregulated Nutrient Sensing | These findings provide evidence that FGF21 is an obligatory metabolic regulator in pancreatic islets and shed new light onto the role of endogenous FGF21 in the pathogenesis of insulin resistance and islet dysfunction. | 25811804 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Associations of fibroblast growth factor-23 with markers of inflammation, insulin resistance and obesity in adults. | 25811862 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Prior studies have shown that FGF23 concentrations are associated with markers of inflammation and insulin resistance but they have been limited by a focus on persons with chronic kidney disease (CKD) and lack of race and sex diversity. | 25811862 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Insulin resistance (IR) is linked with the occurrence of pathological features observed in Alzheimer's disease (AD), including neurofibrillary tangles and amyloid plaques. | 25812851 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Association of genetic variants with dyslipidemia and chronic kidney disease in a longitudinal population-based genetic epidemiological study. | 25813695 |
| Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | The effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in the high-fat-fed ovariectomized rats. | 25814468 |
| Steatohepatitis, Dyslipidemias | Deregulated Nutrient Sensing | Atorvastatin treatment prevented dyslipidemia, reversed hepatic steatosis, optimized composition of bone, and improved bone mechanical properties. | 25814468 |
| Dyslipidemias, Osteoporotic Fractures | Deregulated Nutrient Sensing | The current study provided further evidence that atorvastatin might be useful for the treatment of osteoporotic patients with dyslipidemia. | 25814468 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidemia, obesity and other cardiovascular risk factors in the adult population in Senegal. | 25815102 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In Senegal, the epidemiology of dyslipidemia and obesity are still poorly understood due to the lack of comprehensive studies on their impact on the general population. | 25815102 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The main factors significantly associated with dyslipidemia were obesity, urban dwelling, physical inactivity and a family history of dyslipidemia. | 25815102 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The prevalence of dyslipidemia, obesity and other risk factors in the population was high needing immediate care for those affected and implementation of prevention strategies. | 25815102 |
| Stomach Carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Positive expression of Nampt, Sirt1, p53, P-gp and Topo-IIa was observed to be higher in gastric cancer with diabetes patients compared with gastric cancer patients (P=0.01, 0.003, 0.0025, 0.016 and 0.336, respectively) with reduced survival time. | 25815791 |
| Tacca leontopetaloides, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | History of stroke, high blood pressure, and dyslipidemia were significantly more frequent in patients with TIA. | 25817627 |
| Hepatitis C | Deregulated Nutrient Sensing | TNFa has been shown to play a role in hepatitis C virus (HCV)-induced insulin resistance (IR). | 25818002 |
| Brain Diseases, NGFR protein, human | Deregulated Nutrient Sensing | mRNA levels of Ngfr, Vglut1, Mapk3, Tnf-a, and Sirt1, known targets of the down-regulated miRNAs and abnormal in various human brain disorders, were significantly increased in the HMOX-1-transfected astrocytes. | 25820186 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. | 25822499 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Smoking and its cessation showed dose- and time-dependent relationship with glycemic control and insulin resistance in patients with type 2 diabetes mellitus. | 25822499 |
| Coronary Stenosis, Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes mellitus (DM), dyslipidemia and a history of revascularization was higher in the patients with coronary artery stenosis. | 25822806 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Accumulating evidences demonstrate that abnormalities in whole blood viscosity (WBV) have been implicated in insulin resistance which may lead to non-alcoholic fatty liver disease (NAFLD). | 25823525 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | With the increase of WBV level, participants have larger waist circumference (WC), more severe insulin resistance and the prevalence of NAFLD increased significantly with elevated WBV quartiles. | 25823525 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In multivariable analysis, c was notably positively associated with diabetes mellitus, obesity, hypertension and dyslipidemia and negatively with current smoking. | 25828346 |
| ARCN1 gene, Primary malignant neoplasm, Neoplasms, Pancreatitis, Chronic, Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Obesity | Deregulated Nutrient Sensing | Information on the type, intensity and duration of statin use after cancer diagnosis was extracted from Medicare Part D. We treated statin as a time-dependent variable in a Cox regression model to determine the association with overall survival adjusting for follow-up, age, sex, race, neighborhood income, stage, grade, tumor size, pancreatectomy, chemotherapy, radiation, obesity, dyslipidemia, diabetes, chronic pancreatitis and chronic obstructive pulmonary disease (COPD). | 25830309 |
| melanoma | Deregulated Nutrient Sensing | The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility has yet to be confirmed. | 25832654 |
| Prostate carcinoma | Deregulated Nutrient Sensing | In prostate cancer, low adiponectin levels are not associated with insulin resistance. | 25833038 |
| Malignant neoplasm of prostate | Deregulated Nutrient Sensing | In spite of what would have been expected from the relevant literature, our data suggest that the hypoadiponectinaemia in prostatic cancer does not appear to be associated with insulin resistance. | 25833038 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of hypertension, dyslipidemia and diabetes mellitus were all significantly increased from the CHART-1 to the CHART-2 Study. | 25833177 |
| Hyperglycemia, Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Multiple regression analysis revealed that hypertension, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with obesity. | 25833358 |
| Proteinuria, Hyperglycemia, Dyslipidemias, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | Obesity, blood pressure, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with proteinuria. | 25833358 |
| Hyperglycemia, Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, hyperglycemia and hyperuricemia were independently associated with obesity. | 25833358 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. | 25833778 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Anthocyanin, a natural antioxidant, has been reported to reduce oxidative stress and to attenuate insulin resistance and diabetes in animal models; however, the translation of these observations to humans has not been fully tested. | 25833778 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These findings demonstrate that anthocyanin supplementation exerts beneficial metabolic effects in subjects with type 2 diabetes by improving dyslipidemia, enhancing antioxidant capacity, and preventing insulin resistance. | 25833778 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study was designed to investigate the effects of purified anthocyanins on dyslipidemia, oxidative status, and insulin sensitivity in patients with type 2 diabetes. | 25833778 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The dyslipidemia associated with excess weight is a risk for cardiovascular disease. | 25834504 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In this hospital-based study, the obese children with longer GT repeats in the HO-1 gene promoter and insulin resistance were susceptible to NAFLD. | 25835554 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The apolipoprotein B (APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. | 25837208 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Different postprandial lipid metabolism and insulin resistance between non-diabetic patients with and without coronary artery disease. | 25840497 |
| Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | In patients with abdominal obesity and hypertension were more prevalent family history of hypertension, smoking, dyslipidemia, mainly due to triglycerides, as well as higher levels of fasting glucose. | 25842663 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo. | 25843411 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Up-regulated in pancreatic cancer, SIRT1 is involved in tumorigenesis and drug resistance. | 25843411 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | However the mechanism through which SIRT1 regulates drug sensitivity in cancer cells is mainly unknown. | 25843411 |
| Cessation of life, Pancreatic carcinoma | Deregulated Nutrient Sensing | We hypothesise that inhibiting SIRT1 activity may increase sensitivity of pancreatic cancer cells to gemcitabine treatment through the regulation of apototic cell death, cell cycle, epithelial-mesenschymal-transition (EMT) and senescence. | 25843411 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Growing evidence has shown that ferritin concentrations are associated with obesity and insulin resistance, and with nonalcoholic fatty liver disease. | 25843660 |
| Kidney Diseases | Deregulated Nutrient Sensing | Insulin Resistance Increases the Risk of Contrast-Induced Nephropathy in Patients Undergoing Elective Coronary Intervention. | 25843952 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients were divided into diabetes mellitus (DM = 242), nondiabetic IR (IR = 120), and nondiabetic insulin sensitivity (IS = 357) groups according to medical history and homeostasis model assessment insulin resistance index. | 25843952 |
| Premature coronary artery atherosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | He had cardiac risk factors, including a strong family history of pre-mature coronary artery disease and dyslipidemia. | 25845133 |
| Weight decreased, Dyslipidemias | Deregulated Nutrient Sensing | Univariate and multivariate analysis showed that BMI <50 kg/m(2) (p = 0.006) and dyslipidaemia (p = 0.05) were predictive factors of successful weight loss. | 25845353 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance is associated with impaired cardiac sympathetic innervation in patients with heart failure. | 25845954 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance (IR) represents, at the same time, cause and consequence of heart failure (HF) and affects prognosis in HF patients, but pathophysiological mechanisms remain unclear. | 25845954 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, despite arsenic's association with diabetes in adults and potential role in insulin resistance, our findings do not support the hypothesis that arsenic exposure at levels common in the US contributes to insulin resistance in adolescents. | 25845984 |
| melanoma | Deregulated Nutrient Sensing | In melanoma cells, oncogenic BRAF constitutively activates the extracellular signal-regulated kinase (ERK) pathway and phosphorylates liver kinase B1, an upstream activator of 5' adenosine monophosphate-activated protein kinase (AMPK), resulting in the inactivation of liver kinase B1 and AMPK. | 25846811 |
| Leukemia, Myelocytic, Acute | Deregulated Nutrient Sensing | Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells. | 25846811 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Recently, AMPK has received attention as an attractive molecular target for cancer therapy. | 25846811 |
| Hematologic Neoplasms | Deregulated Nutrient Sensing | Several studies have revealed that the activation of AMPK by chemical stimulators, such as metformin, induces apoptosis in a variety of hematologic malignant cells. | 25846811 |
| Hematologic Neoplasms | Deregulated Nutrient Sensing | From another perspective, these results suggest that the function of AMPK is impaired in hematologic tumor cells. | 25846811 |
| Adult T-Cell Lymphoma/Leukemia | Deregulated Nutrient Sensing | In this study, we analyzed whether ERK is involved in the suppression of AMPK activity using established and primary human leukemia cells. | 25846811 |
| Prediabetes syndrome, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The weighted prevalence of hypertension and dyslipidemia gradually increased in adults with normal glucose regulation, prediabetes, newly-diagnosed diabetes and previously-diagnosed diabetes. | 25848699 |
| Degenerative polyarthritis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is known to be an underlying cause for the development of OA. | 25849372 |
| Obesity, Abdominal, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity, abdominal obesity, dyslipidemia, low education level, and a family history of diabetes were associated with glucose metabolism disorders. | 25850521 |
| Demographics Domain, Dyslipidemias, Sleep disturbances, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Multivariate logistic regression models evaluated the association between sleep disturbances with diabetes mellitus (DM) and the combined outcomes of DM and hypertension as well as DM and dyslipidemia. | 25856540 |
| Sleep Apnea, CTCAE | Deregulated Nutrient Sensing | In fully adjusted models, sleep apnea risk was associated with the combined outcome of DM-hypertension (OR 1.95; 95% CI 1.42-2.69), but not with diabetes-dyslipidemia. | 25856540 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension was the single most important risk factor (71.1%) followed by smoking (46.9%) and dyslipidaemia (45.8%). | 25856914 |
| Hypertensive (finding), Dyslipidemias, diabetic, Coronary heart disease | Deregulated Nutrient Sensing | 83.8% of patients were hypertensive, 36.6% diabetic, 44.5% had dyslipidemia, 15.3% were smokers, 65.7% were overweight/obese, 29.3% had a family history of coronary heart disease. | 25859865 |
| Alzheimers Disease", Inflammation, Data types - Address, Dyslipidemias | Deregulated Nutrient Sensing | Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. | 25862742 |
| AURKAIP1 gene, Mood Disorders | Deregulated Nutrient Sensing | Comorbid mood disorders and TUD further increase AIP but not insulin resistance. | 25863911 |
| Mood Disorders | Deregulated Nutrient Sensing | The results show that mood disorders, TUD and BMI together with elevated levels of uric acid and MDA independently contribute to increased atherogenic potential, while BMI and uric acid are risk factors for insulin resistance. | 25863911 |
| Mood Disorders | Deregulated Nutrient Sensing | The findings show that mood disorders and TUD are closely related to an increased atherogenic potential but not to insulin resistance or the MetS. | 25863911 |
| Mood Disorders | Deregulated Nutrient Sensing | Mood disorders and TUD increase triglyceride levels, lower HDL cholesterol and are strongly associated with the atherogenic, but not insulin resistance, component of the MetS. | 25863911 |
| Overweight, Obesity | Deregulated Nutrient Sensing | The study of the incidence of overweight and obesity as well as body composition and insulin resistance in children from rural communities is scarce. | 25864988 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Impaired mitochondrial function is important in obesity and the development of insulin resistance and diabetes. | 25865306 |
| niobium | Deregulated Nutrient Sensing | Simultaneous to P2, a 24 h hyperinsulinemic-euglycemic clamp (HEC) was performed to determine patients' insulin sensitivity (IS) or insulin resistance (IR), as well as the impact of high doses of insulin on NB. | 25867209 |
| Glucose Intolerance (disease), Liver Cirrhosis | Deregulated Nutrient Sensing | Impaired gastrointestinal-mediated glucose disposal and reduced incretin effect may contribute to the glucose intolerance seen in patients with cirrhosis. | 25867498 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Effects of zinc supplementation on markers of insulin resistance and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. | 25868059 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Expression of the central obesity and Type 2 Diabetes mellitus genes is associated with insulin resistance in young obese children. | 25868061 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Insulin resistance may develop in early stage of childhood obesity and in very young children may be associated with higher expression of the central obesity and Type 2 Diabetes genes. | 25868061 |
| Cholelithiasis | Deregulated Nutrient Sensing | Visceral adiposity is a strong determinant of insulin resistance, which decreases cholecystokinin response sensitivity, and increases cholesterol saturation in the gallbladder bile; thus, it potentially relates to gallstone disease development. | 25869941 |
| Hyperglycemia | Deregulated Nutrient Sensing | Because of associated insulin resistance (IR) the ICU is in dilemma in which stage to start the nutrition to patients and what is the amount of Insulin Unit to control the hyperglycemia. | 25870478 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Tobacco smoking was the most frequent risk factor (54%), followed by dyslipidemia (48.6%) and hypertension (38.6%). | 25874992 |
| Secretory Component Deficiency, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Regarding insulin dynamics, among the NAFLD subjects with both IFG and an HbA1c level of 5.7-6.4%, 25.2% (31/123) had elevated IR alone, 25.2% (31/123) had insulin secretory deficiency alone and 27.6% (34/123) had both elevated insulin resistance and insulin secretory deficiency. | 25876566 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | In the clinical setting, dyslipidemia can be diagnosed based on the detection of elevated lipid concentrations at the beginning of HD. | 25876568 |
| Weight Gain, HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | Evaluating the degree of dyslipidemia at the beginning of a HD session may therefore underestimate the levels of serum lipids in HD patients with a large amount of weight gain, thus resulting in the use of insufficient lipid-lowering therapy. | 25876568 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial. | 25876706 |
| Liver damage | Deregulated Nutrient Sensing | Oral administration of anti-CD3 antibodies induced regulatory T cells (Tregs) alleviating the insulin resistance and liver damage in animal models. | 25876706 |
| Obesity | Deregulated Nutrient Sensing | Most patients suffering from T2DM and from obesity exhibit insulin resistance in the muscles, liver, and fat, resulting in a reduced response of these tissues to insulin. | 25879401 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is a complex disease that is caused by an impairment in the secretion of b-cell insulin and by a peripheral resistance to insulin. | 25879401 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | At the population level, dyslipidaemia is one of the most easily modifiable risk factors of CHD. | 25879518 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | The absence of apparent b-cell deficit in case subjects with GC-induced diabetes suggests that GC-induced diabetes is mainly caused by insulin resistance and/or b-cell dysfunction, but not necessarily a deficit of b-cell mass. | 25883114 |
| Dyslipidemias, Albuminuria, Hypertension, CTCAE | Deregulated Nutrient Sensing | Very high rates of albuminuria, high rates of smoking, dyslipidaemia, hypertension and elevated BMI were recorded. | 25884441 |
| TG gene | Deregulated Nutrient Sensing | The Triglycerides (TG) to High-Density Lipoprotein Cholesterol (HDL-C) ratio is an indirect measure of insulin resistance and an independent predictor of cardiovascular risk. | 25885289 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Compared with nonobese patients without NAFLD, patients with NAFLD had severe systemic (liver/muscle) and, particularly, adipose tissue (fasting/postprandial) insulin resistance (all P < .01). | 25885947 |
| Overweight | Deregulated Nutrient Sensing | However, a well-assembled nutraceutical would be a useful tool to better improve the metabolic parameters associated to overweight and insulin resistance. | 25886384 |
| Hyperlipidemia | Deregulated Nutrient Sensing | Clinical and laboratory data associated to hyperlipidaemia and insulin resistance have been obtained at the baseline, at the end of the first treatment period, after the washout, and again after the second treatment period. | 25886384 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. | 25887236 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) plays a vital role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM). | 25887236 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells. | 25889431 |
| Demographics Domain, Dyslipidemias, Haiti, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | For the highest quartile of the mean carotid IMT (>= 0.863 mm), a male sex, older age, hypertension (HT), dyslipidemia (DL) and type 2 diabetes mellitus (DM) were identified as independent predictors. | 25891209 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These results suggest that the inhibition of SGLT2 and DPP4 improves glucose intolerance and that combined treatment with canagliflozin and teneligliptin is a novel therapeutic option for glycemic control in T2DM. | 25892328 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes was associated with ageing, dyslipidaemia, family history of diabetes, lower physical activity on occupation, intake of lower dietary fibre, and non-literacy in the sampled population. | 25895201 |
| Diabetes Mellitus, diabetic | Deregulated Nutrient Sensing | * Type 2 diabetes mellitus is associated with impaired cognition * Default- mode network plays a central role in maintaining normal cognition * Network connectivity within the default mode was disrupted in type 2 diabetes patients * Decreased network connectivity was correlated with cognitive performance and insulin resistance level * Disrupted default-mode network might explain the impaired cognition in diabetic population. | 25903712 |
| ARCN1 gene | Deregulated Nutrient Sensing | Although the circadian molecular clock regulates inflammatory responses, there is no information available regarding the impact of COPD on lung molecular clock function and its regulation by sirtuin 1 (SIRT1). | 25905433 |
| ARCN1 gene | Deregulated Nutrient Sensing | We hypothesize that the molecular clock in the lungs is disrupted, leading to increased inflammatory responses in smokers and patients with COPD and its regulation by SIRT1. | 25905433 |
| ARCN1 gene | Deregulated Nutrient Sensing | In conclusion, disruption of the molecular clock due to SIRT1 reduction contributes to abnormal inflammatory response in smokers and patients with COPD. | 25905433 |
| Inflammation, Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. | 25905433 |
| Hyperleucinemia | Deregulated Nutrient Sensing | Hyperleptinaemia, insulin resistance and survival in peritoneal dialysis patients. | 25907108 |
| palladium | Deregulated Nutrient Sensing | The aim of this study was to clarify the relationship between insulin resistance (IR) and glucose and lipid metabolism in peritoneal dialysis (PD) patients. | 25907108 |
| Familial generalized lipodystrophy, Muscle hypertrophy | Deregulated Nutrient Sensing | Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare disease characterized by near absence of adipose tissue resulting in apparent muscle hypertrophy from birth or early infancy associated with severe insulin resistance. | 25910311 |
| Apolipoproteins B | Deregulated Nutrient Sensing | Discordance between apolipoprotein B and low-density lipoprotein particle number is associated with insulin resistance in clinical practice. | 25911082 |
| Discordance, Inflammation | Deregulated Nutrient Sensing | Discordance (LDL-PNMR > apoB) was associated with insulin resistance, smaller LDL particle size, increased systemic inflammation, and low circulating levels of "traditional" lipids, whereas discordance (apoB > LDL-PNMR) was associated with larger LDL particle size, and elevated levels of lipoprotein(a) and lipoprotein-associated phospholipase A2 (Lp-PLA2). | 25911082 |
| Dental Plaque | Deregulated Nutrient Sensing | The role of insulin resistance and metabolic risk factors on culprit coronary plaque. | 25912124 |
| Dental Plaque | Deregulated Nutrient Sensing | We investigated the role of insulin resistance (IR) on culprit coronary plaque. | 25912124 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Protein levels of SIRT1 and SIRT2 were determined in non-small cell lung cancer (NSCLC) cell lines and primary tumors from 105 patients. | 25915617 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Changes in proliferation were assessed after SIRT1 and SIRT2 downregulation in lung cancer cell lines using siRNA-mediated technology or tenovin-1, a SIRT1 and SIRT2 inhibitor. | 25915617 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | High SIRT1 and SIRT2 protein levels were found in NSCLC cell lines compared with non-tumor lung epithelial cells. | 25915617 |
| Primary Neoplasm | Deregulated Nutrient Sensing | The expression of SIRT1 and SIRT2 proteins was also significantly higher in lung primary tumors than in normal tissue (P<0.001 for both sirtuins). | 25915617 |
| Adenocarcinoma, Squamous cell carcinoma | Deregulated Nutrient Sensing | Stronger nuclear SIRT1 staining was observed in adenocarcinomas than in squamous cell carcinomas (P=0.033). | 25915617 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Interestingly, in NSCLC patients, high SIRT1 and SIRT2 expression levels were associated with shorter recurrence-free survival (P=0.04 and P=0.007, respectively). | 25915617 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | In vitro studies showed that SIRT1 and/or SIRT2 downregulation significantly decreased proliferation of NSCLC. | 25915617 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Our results support the hypothesis that SIRT1 and SIRT2 have a protumorigenic role in lung cancer, promoting cell proliferation. | 25915617 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. | 25915617 |
| Hyperglycemia, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | The presence of abdominal obesity, hyperglycaemia, dyslipidaemia and elevated blood pressure was clinically evaluated in 1994-96. | 25918184 |
| Hyperglycemia, Metabolic Diseases, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Significant associations were also found with several cardiometabolic disorders (hyperglycaemia, central obesity and dyslipidaemia) and specific cognitive domains. | 25918184 |
| T-Cell Lymphoma, Neoplasms | Deregulated Nutrient Sensing | The mTORC1 inhibitor everolimus has antitumor activity in vitro and produces tumor responses in patients with relapsed T-cell lymphoma. | 25921059 |
| Simultaneous | Deregulated Nutrient Sensing | Compared to baseline, metformin significantly improved metabolic parameters and insulin sensitivity, increased SIRT1 gene/protein expression and SIRT1 promoter chromatin accessibility, elevated mTOR gene expression with concomitant reduction in p70S6K phosphorylation in subjects' PBMCs, and modified the plasma N-glycan profile. | 25921843 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | Association between atherogenic dyslipidemia and recurrent stroke risk in patients with different subtypes of ischemic stroke. | 25924059 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | The association between atherogenic dyslipidemia and stroke recurrence remains unclear, and may be influenced by different subtypes of ischemic stroke. | 25924059 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | We aimed to investigate whether atherogenic dyslipidemia contributed to stroke recurrence in ischemic stroke patients and in those with certain subtypes of ischemic stroke. | 25924059 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia was defined as high-density lipoprotein cholesterol <40 mg/dl and triglycerides >=200 mg/dl. | 25924059 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | The association between atherogenic dyslipidemia and stroke recurrence was analyzed by using multivariable Cox regression model. | 25924059 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | In the 510 ischemic stroke patients, 64 patients (12*5%) had atherogenic dyslipidemia, and 66 patients (12*9%) experienced stroke recurrence events within 24 months. | 25924059 |
| Atherosclerosis of renal artery, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Kaplan-Meier analysis revealed that stroke recurrence rate was significantly higher in patients with atherogenic dyslipidemia than those without in all the stroke patients (20*3% vs. 11*9%; P = 0*048), and more evident in those of large-artery atherosclerosis subtype (31*0% vs. 14*1%; P = 0*014), but not in the other subtypes. | 25924059 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is associated with higher risk of stroke recurrence in ischemic stroke patients. | 25924059 |
| Dyslipidemias, Toxic effect | Deregulated Nutrient Sensing | A better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM. | 25924608 |
| Inflammation, Angina Pectoris, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | Inflammation and dyslipidaemia may play an important role in the development of atherosclerotic complications, for example myocardial infarction and angina pectoris. | 25924966 |
| Autoimmune thyroiditis, Adrenal incidentaloma | Deregulated Nutrient Sensing | The association of autoimmune thyroiditis and non-functional adrenal incidentalomas with insulin resistance. | 25926113 |
| Dyslipidemias, Non-Functioning Adrenal Cortex Adenoma, Obesity | Deregulated Nutrient Sensing | Patients with incidental nonfunctioning adrenal adenoma are associated with increased risk of obesity, impaired glucose tolerance and dyslipidemia. | 25926113 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The association did not persist after additionally adjusting for traditional atherogenic risk factors including visceral fat, smoking, hypertension, dyslipidemia, and diabetes. | 25935114 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperglycaemia and dyslipidaemia in diabetes mellitus induce increased lipid peroxidation and peroxyl radical formation is an important mechanism in genesis of micro-angiopathy. | 25935946 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Skeletal myocytes are metabolically active and susceptible to insulin resistance and are thus implicated in type 2 diabetes (T2D). | 25937284 |
| Mitochondrial Biogenesis | Deregulated Nutrient Sensing | Finally, activation of AMPK by A-769662 increased PGC-1a expression via SIRT-1 and reversed impairments in mitochondrial biogenesis, oxidative phosphorylation, and intracellular ATP in human knee OA chondrocytes. | 25940958 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | TFAM-mediated activation of the AMPK/SIRT-1/PGC-1a pathway reverses these effects, suggesting translational potential of pharmacologic AMPK activators to limit OA progression. | 25940958 |
| Increased insulin level, Hypertensive (finding) | Deregulated Nutrient Sensing | Higher Waist Circumference, Fasting Hyperinsulinemia And Insulin Resistance Characterize Hypertensive Patients With Impaired Glucose Metabolism. | 25944063 |
| Increased insulin level, Hypertensive (finding) | Deregulated Nutrient Sensing | The present study, performed in a selected population of hypertensive subjects, shows that derangement of glucose metabolism is associated to central fat accumulation, hyperinsulinemia and insulin resistance. | 25944063 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin Resistance and Risk of Cardiovascular Disease in Postmenopausal Women: A Cohort Study From the Women's Health Initiative. | 25944628 |
| Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is associated with diabetes mellitus, but it is uncertain whether it improves cardiovascular disease (CVD) risk prediction beyond traditional cardiovascular risk factors. | 25944628 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Measures of insulin resistance were no longer associated with CVD risk after adjustment for high-density lipoprotein-cholesterol and did not provide independent prognostic information in postmenopausal women without diabetes mellitus. | 25944628 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings may aid in predicting a patient's risk of developing dyslipidemia. | 25944971 |
| Amyotrophic Lateral Sclerosis, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance in patients with amyotrophic lateral sclerosis (ALS) has been inconsistently reported. | 25947580 |
| Refractory anemias, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These results show that circulating RA concentrations were lower in subjects with NAFLD and were associated with hepatic lipid metabolism and insulin resistance. | 25948673 |
| Gestational Diabetes, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Prevalence of glucose intolerance at 6 weeks postpartum in Indian women with gestational diabetes mellitus. | 25952037 |
| Gestational Diabetes, Glucose Intolerance (disease), Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Women with a history of gestational diabetes mellitus (GDM) have an increased risk for future glucose intolerance, and should be followed up with subsequent screening for the development of diabetes or pre-diabetes at 6-12 weeks postpartum. | 25952037 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Metabolically obese but normal weight (MONW) is associated with higher risk of type 2 diabetes, dyslipidemia, and hypertension. | 25952300 |
| Heart Diseases, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | General practitioners considered most frequently the presence of underlying heart disease (C: 35.0%, G: 5.0%, MG: 45.0%; P<0.05) as well as usual cardiovascular risk factors (overweight, dyslipidaemia; P<0.05). | 25956749 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Carotid atherosclerosis in patients with ESKD has decreased over the past 9 years, which may be a consequence of improvements in dyslipidemia management. | 25957119 |
| Osage language | Deregulated Nutrient Sensing | In contrast, neither insulin resistance nor sleep measurements related to OSA were found to be modified by fetuin-A concentrations. | 25960379 |
| ETV3 wt Allele, Osage language | Deregulated Nutrient Sensing | In conclusion, abnormalities of lipoprotein metabolism, but not MetS or insulin resistance per se, may represent a mechanism by which fetuin-A contributes to increased CVD risk in patients with OSA. | 25960379 |
| Alzheimers Disease", Obesity | Deregulated Nutrient Sensing | Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. | 25963004 |
| Fatty degeneration, Diabetes Mellitus, Non-Insulin-Dependent, Skeletal muscle structure | Deregulated Nutrient Sensing | It has recently been reported that myosteatosis, the infiltration of fat in skeletal muscle, is associated with insulin resistance and type 2 diabetes mellitus. | 25963482 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc. | 25965392 |
| Tumor necrosis, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We examined changes in adiponectin (APN) and tumor necrosis factor-a (TNF-a) in type 2 diabetes mellitus (T2DM) complicated by NAFLD and their relationships with insulin resistance (IR). | 25966055 |
| Glucose Intolerance (disease), Rhabdomyositis | Deregulated Nutrient Sensing | MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. | 25968578 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Physical inactivity in older adults is a risk factor for developing glucose intolerance and impaired skeletal muscle function. | 25968578 |
| Glucose Intolerance (disease), Myositis | Deregulated Nutrient Sensing | We hypothesize that a physical inactivity stimulus, capable of inducing glucose intolerance, would increase skeletal muscle inflammation and ceramide biosynthesis signaling and that this response would be regulated by the TLR/MyD88 pathway. | 25968578 |
| Obesity | Deregulated Nutrient Sensing | Association between Obesity Indices and Insulin Resistance among Healthy Korean Adolescents: The JS High School Study. | 25970186 |
| Obesity | Deregulated Nutrient Sensing | To investigate whether indices of obesity are associated with insulin resistance in Korean adolescents. | 25970186 |
| Obesity | Deregulated Nutrient Sensing | Logistic regression models were used to estimate odds ratio for insulin resistance according to seven obesity indices. | 25970186 |
| Obesity | Deregulated Nutrient Sensing | Our findings suggest that obesity indices are positively associated with insulin resistance in apparently healthy adolescents. | 25970186 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Liver fat accumulation, as reflected by the FLI, and dyslipidemia, as reflected by triglycerides, may partly explain the association between estimated D5D, D6D, and SCD activity and T2D risk. | 25971719 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Insulin resistance using HOMA model in obstructive sleep apnea: a cross sectional study. | 25971819 |
| Osage language | Deregulated Nutrient Sensing | Current evidences show inconclusive association between OSA and insulin resistance (IR). | 25971819 |
| Acute Lung Injury | Deregulated Nutrient Sensing | Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1. | 25972997 |
| Acute Lung Injury | Deregulated Nutrient Sensing | miR-320 may mediate the ALI after CPB in which alveolar epithelial cells are injured via down-regulating SIRT1. | 25972997 |
| Cancer-related fatigue, Dyslipidemias | Deregulated Nutrient Sensing | Our investigation reveals a differential trajectory of lipids and lipoproteins with aging according to CRF in healthy men and suggests that promoting increased CRF levels may help delay the development of dyslipidemia. | 25975472 |
| RECIL MR, Dyslipidemias, Coronary Artery Disease, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | Patients with increasing grade of MR were elder (P<0.001), more likely to be female (P=0.003), have atrial fibrillation (P<0.001), higher peak C-reactive protein values (P=0.001), multivessel coronary artery disease (P<0.001), and less likely to have dyslipidemia (P=0.029). | 25975877 |
| Hepatitis B, Fever, CTCAE, Headache, Dyslipidemias | Deregulated Nutrient Sensing | A 61-year-old man with chronic hepatitis B and dyslipidemia visited the emergency department with a fever and severe headache. | 25977161 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | to study the association of two miRNAs; 9 and 370, with biochemical parameters of type 2 diabetic (T2D), dyslipidemia and coronary artery disease (CAD). | 25978320 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lack of regular physical activity at prescribed intensity levels is a modifiable risk factor for insulin resistance and the development of diabetes. | 25979318 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The primary objective of the Aerobic Plus Resistance Training and Insulin Resistance in African American Men (ARTIIS) study is to determine the effectiveness of an exercise training intervention aimed at reducing diabetes risk factors in African American men at risk for developing diabetes. | 25979318 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Drugs for hyperglycaemia, hypertension, and dyslipidaemia were prescribed by protocol. | 25979364 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Also in this setting, dyslipidemia (P = .068) showed a tendency of association with hypertension. | 25979413 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The adverse effects of hyperglycemia may be potentiated when it is accompanied with hypertension and dyslipidemia. | 25982678 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | The predominant underlying mechanism of MetS is insulin resistance (IR). | 25984973 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidaemia is the main risk factor for coronary heart disease (CHD). | 25985729 |
| Colorectal Neoplasms, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes and dyslipidemia have been linked to an increased risk of colorectal neoplasm (CRN). | 25986527 |
| Dyslipidemias, Obesity, Abdominal, Congenital Heart Defects | Deregulated Nutrient Sensing | Women with NWO had cardiometabolic abnormalities including abdominal obesity, dyslipidaemia and increased blood pressure. | 25987469 |
| Arterial Stiffness, Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Dental Plaque | Deregulated Nutrient Sensing | Advanced fibrosis indicated by NFS was positively associated with CIMT, presence of carotid plaque and arterial stiffness in the NAFLD patients, independent of conventional cardiometabolic risk factors and insulin resistance. | 25988358 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Lifestyle changes and statins are the cornerstones in management of dyslipidaemia in patients with HIV infection. | 25989829 |
| Sarcopenia, Obesity | Deregulated Nutrient Sensing | In males, obesity (OR=3.7; 95% CI 1.2, 10.8), insulin resistance (OR=3.0; 95% CI 1.1, 8.2), physical inactivity (OR=2.9; 95% CI 1.1, 7.7) and sarcopenia (OR=21.2; 95% CI 4.2, 107.5) significantly increased the risk of MetS. | 25990645 |
| Sarcopenia | Deregulated Nutrient Sensing | In both sexes, sarcopenia and insulin resistance were important risk factors of MetS. | 25990645 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Over time, there was a significant increase in physical inactivity, alcohol consumption, diabetes, dyslipidemia, and excessive weight. | 25993592 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension was present in 29.7% of patients, followed by diabetes (14.9%), current tobacco use (7.6%), and dyslipidemia (6.5%). | 25994444 |
| Dyslipidemias | Deregulated Nutrient Sensing | There is growing evidence that glucose fluctuation, as a residual risk apart from dyslipidemia, is an important factor contributing to the development of CAD. | 25999102 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis B, Chronic | Deregulated Nutrient Sensing | First, elevated AGE levels were observed in CHC patients than patients with chronic hepatitis B, especially in those with insulin resistance. | 26002589 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Several studies have reported that insulin resistance was a major risk factor for the onset of type 2 diabetes mellitus in individuals without diabetes or obesity. | 26005064 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | We aimed to clarify the association between insulin resistance and glycemic control in Japanese subjects without diabetes or obesity. | 26005064 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease. | 26006114 |
| Overgrowth, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Despite not differing in dietary pattern or prevalence of intestinal overgrowth, fasting ethanol levels being positively associated with measures of insulin resistance were significantly higher in children with NAFLD than in controls. | 26006114 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, hypertension and dyslipidemia were the most frequent common co-morbidities. | 26006196 |
| Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Furthermore, linagliptin alleviated Ab-induced mitochondrial dysfunction and intracellular ROS generation, which may be due to the activation of 5' AMP-activated protein kinase (AMPK)-Sirt1 signaling. | 26010513 |
| Data types - Address, diabetic | Deregulated Nutrient Sensing | This upregulation of Sirt1 expression was also observed in diabetic patients with AD coadministration of linagliptin. | 26010513 |
| Inflammation, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Evidence shows a high incidence of insulin resistance, inflammation and dyslipidemia in adult obesity. | 26011530 |
| Inflammation, Overweight | Deregulated Nutrient Sensing | The overweight subjects only exhibited significant insulin resistance and low-grade inflammation. | 26011530 |
| Meningioma | Deregulated Nutrient Sensing | Merlin expression, encoded by the NF2 gene, is lost in a majority of meningiomas, and merlin is a negative regulator of mTORC1. | 26015296 |
| Microalbuminuria, Dyslipidemias, Retinal Diseases, Diabetic Ketoacidosis, Hypertension, CTCAE | Deregulated Nutrient Sensing | An inverse association between PA and HbA(1c), diabetic ketoacidosis, BMI, dyslipidemia (all P < 0.0001), and hypertension (P = 0.0150), as well as between PA and retinopathy or microalbuminuria (both P < 0.0001), was present. | 26015557 |
| Dyslipidemias, Ischemic stroke, Atherosclerosis | Deregulated Nutrient Sensing | The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. | 26016451 |
| Dyslipidemias | Deregulated Nutrient Sensing | A low testosterone level in men is associated with increased adiposity, insulin resistance, and dyslipidemia. | 26022684 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results indicate that, although not associated with T2DM, the G allele of rs3480 appears to be associated with increased HbA1c, while the T allele of rs1746661 appears to be associated with higher systolic blood pressure and dyslipidemia in women with T2DM. | 26024756 |
| APP gene, Dyslipidemias, Smoking | Deregulated Nutrient Sensing | Smoking, dyslipidemia, and rs1800469 together contributed to the risk of AAA, which demonstrated a potential and complex gene-environment interaction among the three variants that might affect AAA risk (CVC 6/10; p = .001). | 26027897 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular events correlated with CAD severity (HR 2.27, 95% CI 1.13-4.54), age (HR 1.04, 1.01-1.06), previous cardiovascular disease (HR 1.75, 1.05-4.42), dyslipidemia (HR 2.25, 1.11-4.53), lipoprotein (a) (HR 1.01, 1.00-1.02), troponin I (HR 3.89, 1.07-14.18), fibrinogen levels (HR 1.38, 0.98-1.94) and antiplatelet therapy (HR 2.14, 1.04-4.4). | 26029907 |
| Having administered, Hypogonadism, Dyslipidemias | Deregulated Nutrient Sensing | The Effect of Testosterone and Fenofibrate, Administered Alone or in Combination, on Cardiometabolic Risk Factors in Men with Late-Onset Hypogonadism and Atherogenic Dyslipidemia. | 26031507 |
| Hypogonadism, Dyslipidemias | Deregulated Nutrient Sensing | Our study shows that fenofibrate produces a stronger effect on cardiometabolic risk factors in men with late-onset hypogonadism and atherogenic dyslipidemia than oral testosterone undecanoate. | 26031507 |
| Acute Coronary Syndrome, Heart failure | Deregulated Nutrient Sensing | Admission Glycaemia and Acute Insulin Resistance in Heart Failure Complicating Acute Coronary Syndrome. | 26031570 |
| Acute heart failure, F8 wt Allele | Deregulated Nutrient Sensing | Few data are so far available on the relation between increased glucose values and insulin resistance and mortality at short-term in patients with acute heart failure (AHF). | 26031570 |
| Cessation of life | Deregulated Nutrient Sensing | Admission glycaemia was an independent predictor of in-ICCU mortality, together with admission LVEF and eGFR, while acute insulin resistance (as indicated by HOMA-index) was not associated with early death. | 26031570 |
| Communicable Diseases | Deregulated Nutrient Sensing | Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection. | 26031763 |
| herpesvirus 1, human | Deregulated Nutrient Sensing | We previously showed that the sensors AMP-dependent kinase (AMPK) and Sirtuin 1 (Sirt1), involved in survival pathways and neuroprotection, were affected during the course of HSV-1 infection. | 26031763 |
| Communicable Diseases, Liver damage | Deregulated Nutrient Sensing | These results suggest that activators of the AMPK/Sirt1 axis could be potentially useful in reducing the risk of HSV-1 productive infection in neurons and the cellular damage associated with reactivation episodes. | 26031763 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We assessed 106 T2DM patients, median age 62 years, 46% women, 19% smokers, 54% with hypertension, and 41% with dyslipidemia and 99 non-diabetic subjects matched by age, sex, and cardiovascular risk factors. | 26033395 |
| Acromegaly | Deregulated Nutrient Sensing | VAT and SAT masses were lower than predicted in active acromegaly, but increased after surgery in male and female subjects along with lowering of GH, IGF-I, and insulin resistance. | 26037515 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD) has been proposed as the hepatic manifestation of the metabolic syndrom (Ms), with insulin resistance (IR) as the common pathophysiological mechanism. | 26040357 |
| Asthma | Deregulated Nutrient Sensing | Increases in peripheral SIRT1: a new biological characteristic of asthma. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | However, no data are available regarding SIRT1 expression in patients with asthma. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | Here, we studied SIRT1 levels in the serum of patients with asthma and analysed the distribution of SIRT1 in both the serum and the lungs in an asthmatic mouse model to determine its clinical significance. | 26040995 |
| eosinophil, Asthma | Deregulated Nutrient Sensing | Serum SIRT1 levels, total immunoglobulin E (IgE) levels and peripheral blood eosinophil percentages as well as pulmonary function were quantified in 97 patients with asthma and 118 healthy volunteers. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | BALB/c mice were sensitized and challenged using ovalbumin (OVA) to produce the asthmatic model, and SIRT1 levels in both the serum and the lung tissues were subsequently measured. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | The serum SIRT1 levels were significantly elevated in the patients with asthma compared with the controls. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | These data indicate that lung SIRT1 expression decreased while serum SIRT1 increased in the setting of asthma. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | Serum SIRT1 levels correlate positively with both IgE levels and negatively with pulmonary function, suggesting that increased peripheral SIRT1 levels represent a new biological characteristic of asthma. | 26040995 |
| Asthma | Deregulated Nutrient Sensing | Increased serum SIRT1 may be an auxiliary index for the diagnosis of asthma and elevating lung SIRT1 levels may be a new strategy for asthma therapy. | 26040995 |
| Diabetic Nephropathy, Diabetes Mellitus | Deregulated Nutrient Sensing | Glycosphingolipids (GSLs) play a role in insulin resistance and diabetes, but their role in diabetic nephropathy (DN) has received limited attention. | 26041445 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia remains a significant risk factor for cardiovascular disease and additional lipid-modifying treatments are warranted to further decrease the cardiovascular disease burden. | 26047975 |
| Increased insulin level, Sensorineural Hearing Loss (disorder), Cone-Rod Dystrophy 2, Diabetes Mellitus, Autosomal Recessive Disorder, Liver Dysfunction, Obesity | Deregulated Nutrient Sensing | Alstrom syndrome (AS) is an autosomal recessive disorder, characterized by cone-rod dystrophy, sensorineural hearing loss, obesity, hyperinsulinemia with insulin resistance, type 2 diabetes mellitus and progressive pulmonary, hepatic and renal dysfunction. | 26048691 |
| Depression, CTCAE, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Putative role for insulin resistance in depression risk in polycystic ovary syndrome. | 26054555 |
| Prostate Cancer Outcomes Study, Depression, CTCAE, Obesity | Deregulated Nutrient Sensing | Our data suggest a complex interplay among insulin resistance, obesity, and depression in PCOS, warranting additional investigation. | 26054555 |
| Neoplasms | Deregulated Nutrient Sensing | Several members of the SIRT family (SIRT1-7), which are a highly conserved family of NAD(+)-dependent enzymes, play an important role in tumor formation. | 26054687 |
| Inflammation, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results provide further support of "kynurenine hypothesis of insulin resistance and its progression to T2D" that suggested that overproduction of diabetogenic KP metabolites, induced by chronic stress or chronic low-grade inflammation, is one of the mechanisms promoting development of T2D from pre-diabetes. | 26055228 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Serum retinol-binding protein 4 (RBP4) is the sole specific transport protein for retinol in the blood, but it is also an adipokine with retinol-independent, proinflammatory activity associated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. | 26055327 |
| Dyslipidemias | Deregulated Nutrient Sensing | In general, the cut-off values of the anthropometric predictors of dyslipidemia increased with age, except for waist-to-height ratio. | 26057185 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although green and yellow vegetables have beneficial effects against type 2 diabetes, the relationship of their nutritive content with insulin resistance is poorly understood. | 26059371 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia was 15%, increased with age (p = < 0.01) did and not differ significantly according to sex. | 26060959 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The prevalence of dyslipidemia in the central-west of Brazil was increased with age and was associated with bean consumption, excess weight (overweight and obesity) and self-rated health as poor. | 26060959 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Glucose fluctuation has been recognized as a residual risk apart from dyslipidemia for the development of coronary artery disease (CAD). | 26062762 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Daily Physical Activity Assessed by a Triaxial Accelerometer Is Beneficially Associated with Waist Circumference, Serum Triglycerides, and Insulin Resistance in Japanese Patients with Prediabetes or Untreated Early Type 2 Diabetes. | 26064983 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Objectively measured daily physical activity is beneficially associated with waist circumference, serum triglycerides, and insulin resistance in individuals with prediabetes or untreated early T2D. | 26064983 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Compared to low-risk patients, patients who underwent ICAwere older, and had a higher frequency of hypertension, diabetes mellitus and dyslipidemia. | 26065214 |
| ARCN1 gene, Inflammation | Deregulated Nutrient Sensing | Lung function, leukocyte telomere length, lymphocyte gene expression of anti-aging (sirtuin 1, total klotho, and soluble klotho [Sklotho]), senescence (p16/21), and DNA repair (Ku70/80 and TERF2) proteins, and markers of systemic inflammation and oxidative stress were determined in 160 patients with COPD, 82 smoking subjects, and 38 never-smoking control subjects. | 26066545 |
| Dyslipidemias | Deregulated Nutrient Sensing | Previous studies suggested that dyslipidemia was potentially associated with anti-diabetic medications of sulfonylureas (SUs). | 26066789 |
| Triglycerides, Dyslipidemias, Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of undiagnosed diabetes, high triglycerides, high low-density lipoprotein (LDL), low high-density lipoprotein (HDL), and atherogenic dyslipidemia (AD) was 4.7%, 31.8%, 31.3%, 25.9%, and 14.6%, respectively. | 26068010 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The association between white rice consumption and diabetes and dyslipidemia markers varied across regions of China, suggesting a role of other dietary and health-related exposures, beyond rice. | 26068010 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obese elderly women with and without type 2 diabetes have a similar degree of insulin resistance of protein anabolism, despite worse glucose metabolism in type 2 diabetes. | 26068615 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Low-grade inflammation, as measured by hs-CRP level, may have an important role in the development of diabetes among African Americans with a lesser degree of insulin resistance. | 26068864 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of hypertension, dyslipidemia and diabetes was 33.5, 17.5, 5% respectively. | 26068976 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance. | 26073386 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Chinese patients with obesity and type II diabetes have significantly lower plasma CTRP-3 concentrations than healthy subjects do, and plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance. | 26073386 |
| Xanthoma, Arteriosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Giant xanthomas associated with severe mixed dyslipidemia and arteriosclerotic vascular disease: A case report. | 26073402 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of undiagnosed diabetes was 2.6% (29 individuals); glucose intolerance was detected in 1.3% (14 individuals). | 26074216 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | There is a low prevalence of undiagnosed diabetes and glucose intolerance in the rural population of River Nile State. | 26074216 |
| Rectum, Fibromyalgia, Dyslipidemias, Depression, CTCAE, Ichthyosis Bullosa of Siemens | Deregulated Nutrient Sensing | The most common associated diseases observed in patients with IBS were: depression (27.19%), dyslipidemia (25.43%), hemorrhoidal disease (22.80%) and fibromyalgia (21%). | 26076563 |
| Rectum, Fibromyalgia, Dyslipidemias | Deregulated Nutrient Sensing | Other diseases with a high incidence: dyslipidemia, hemorrhoidal disease and fibromyalgia. | 26076563 |
| Atherosclerosis, Dyslipidemias, Cerebrovascular accident, Heart Diseases, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Risk factors of stroke such as hypertension, diabetes mellitus, dyslipidemia, atherosclerosis, stroke history, and heart disease were recorded. | 26077180 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance. | 26077345 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, correlations with FBG and insulin resistance were diminished in T2D subjects. | 26077345 |
| Hyperparathyroidism, Primary, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Previous studies demonstrated insulin resistance and increased prevalence of impaired glucose tolerance and type 2 diabetes mellitus in patients with primary hyperparathyroidism (PHPT). | 26077384 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | All patients received a personalized dietary guideline with nutritional recommendations for dyslipidemia and hypertension and were followed for 90 days. | 26077768 |
| Steatohepatitis, Psoriasis | Deregulated Nutrient Sensing | To investigate spleen status in psoriasis and its relationship with hepatic steatosis, Psoriasis Area and Severity Index, and insulin resistance. | 26078565 |
| Psoriasis | Deregulated Nutrient Sensing | The following relevant data were collected: age, sex, weight, height, body mass index, waist circumference, blood pressure, insulin resistance status, age at psoriasis onset, and severity of psoriasis. | 26078565 |
| Dyslipidemias | Deregulated Nutrient Sensing | Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation. | 26083362 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | In multivariable logistic regression analysis female sex, BMI, WC, WHR and WHtR, HTN and dyslipidaemia remain significantly more common among high risk participants (p < 0.05 and p < 0.001). | 26084331 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Ingestion of probiotics can modify gut microbiota and alter insulin resistance and diabetes development in rodents. | 26084343 |
| Dyslipidemias, IFNG wt Allele, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Age, male gender, obesity, urban residency, high family income and presence of dyslipidaemia were found to be significant risk factors for diabetes and IFG. | 26085648 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Eighty percent of participants (n = 83) fell into the mEOSS-2 group and had obesity-related chronic disorders, such as diabetes, hypertension, and/or dyslipidemia. | 26086402 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes was defined by calculated measures of glycemic control and insulin resistance. | 26087382 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Within a population of 146,064 patients with dyslipidemia in the PINNACLE Registry and a subgroup of 36,188 patients with diabetes mellitus (DM), we examined the proportion of patients and patient characteristics associated with having LDL-C, non-HDL-C, and both LDL-C and non-HDL-C levels at National Cholesterol Education Program goals. | 26089010 |
| Steatohepatitis, Fat-free mass, muscle mass | Deregulated Nutrient Sensing | Fat-free mass and muscle mass significantly increased, whereas hepatic steatosis grade, mean insulin and ferritin levels, and the homeostasis model assessment-estimated insulin resistance index were significantly decreased in the exercise group. | 26090879 |
| Cessation of life, Adult T-Cell Lymphoma/Leukemia | Deregulated Nutrient Sensing | Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells. | 26091232 |
| TRPV6 gene | Deregulated Nutrient Sensing | We previously reported that ATL patients had significantly higher SIRT1 protein levels than healthy controls. | 26091232 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Discriminatory value of alanine aminotransferase for diabetes prediction: the Insulin Resistance Atherosclerosis Study. | 26094705 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The crude average of the maximum IMT increased significantly with rising quartiles of HbA1c, GA, FPG, and 2-hour PG levels in subjects with and without glucose intolerance (GI), while no clear association was observed for 1,5-AG. | 26099223 |
| Dyslipidemias, Diverticular Bleeding, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In univariate analysis, hypertension, dyslipidemia, chronic kidney disease, and NSAIDs use, low-dose aspirin, non-aspirin antiplatelets, increasing BMI, and increasing VAT area were associated with diverticular bleeding. | 26099321 |
| Diabetes, Autoimmune, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Vitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults. | 26101151 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity | Deregulated Nutrient Sensing | Among cardiovascular risk factors, dyslipidemia, obesity, smoking, and a family history of CVD did not affect self-perceived health. | 26103790 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis. | 26105582 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The aim of the current study is to investigate the effect of fenofibrate alone and in combination with pioglitazone on serum sirtuin 1 and fetuin A of obese patients with Type 2 Diabetes Mellitus (T2DM). | 26105582 |
| Obesity | Deregulated Nutrient Sensing | Fenofibrate, alone and in combination with pioglitazone, significantly decreased triacylglycerol, hs-CRP, IL-6, fetuin A and increased sirtuin 1 levels (P<0.001) which suggests that it can be used to delay the complications of obesity and T2DM. | 26105582 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients had multiple risk factors at inclusion on renal transplantation waiting list as high blood pressure (94.7%), dyslipidemia (81.1%), smoking (45.3%), diabetes (23.6%), past history of cardiovascular disease (21.3%) and obesity (12.7%). | 26107641 |
| Neuropathology, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | The present results suggest that AD-like neuropathology extends to the pancreas in the 3xTg-AD mouse, leading to glucose intolerance and contributing to a pathologic self-amplifying loop between AD and T2D. | 26108977 |
| ARCN1 gene, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In training population the variables gender (men/women OR: 1.7, 95%CI: 1.237-2.5, P < 0.05), dyslipidemia (OR: 1.8, 95%CI: 1.2-2.5, P < 0.01) and smoking habit (OR: 1.5, 95%CI: 1.2-1.9, P < 0.001) were significantly associated with CAD in COPD patients, whereas in control population also age and diabetes were correlated. | 26111914 |
| Progeria | Deregulated Nutrient Sensing | AMPK-activating compounds including metformin and resveratrol may thus embody a novel treatment paradigm linking the pathophysiology of HGPS with that of HIV-1 latency. | 26115946 |
| Dyslipidemias, Dysglycemia, Prediabetes syndrome | Deregulated Nutrient Sensing | Dietary habits and leisure-time physical activity in relation to adiposity, dyslipidemia, and incident dysglycemia in the pathobiology of prediabetes in a biracial cohort study. | 26116207 |
| diabetic | Deregulated Nutrient Sensing | High MPV quartiles were linearly associated with fasting glucose and glycated hemoglobin but not with diabetic duration or insulin resistance. | 26120789 |
| Prediabetes syndrome, Obesity | Deregulated Nutrient Sensing | We report on the systemic levels of RBP4 and TTR and their associations with insulin resistance, obesity, prediabetes, and T2DM in Asian Indians. | 26121433 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Circulatory levels of RBP4 and TTR showed a significant associations with glucose intolerance, obesity, T2DM and RBP4 additionally, with insulin resistance. | 26121433 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin resistance. | 26122877 |
| Parkinson Disease, Vertigo | Deregulated Nutrient Sensing | Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease. | 26130063 |
| Cessation of life | Deregulated Nutrient Sensing | Our in vitro study suggests that SIRT1 function is inhibited by oxidative stress, which thereby promotes 6-hydroxydopamine-induced cell death. | 26130063 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common comorbidities were hypertension (70.8%), dyslipidemia (36.7%) and diabetes (34%). | 26131698 |
| ARCN1 gene, Primary malignant neoplasm, Dyslipidemias, Chronic Obstructive Airway Disease, Colorectal Carcinoma, Liver Cirrhosis | Deregulated Nutrient Sensing | Based on multivariate analysis among patients with CRC, age >=70 years, men, chronic obstructive pulmonary disease (COPD), cirrhosis, and dyslipidemia were independent predictors of an SPM.In conclusion, patients with CRC were at increased risk for a second cancer. | 26131831 |
| ARCN1 gene, Dyslipidemias, Liver Cirrhosis | Deregulated Nutrient Sensing | Age, men, COPD, cirrhosis, and dyslipidemia were independent risk factors for SPMs. | 26131831 |
| Overweight, Cardiovascular Diseases | Deregulated Nutrient Sensing | Infants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. | 26132470 |
| Pulmonary Embolism, Dyslipidemias | Deregulated Nutrient Sensing | The annual prevalence of ORCs ranged from 0.5% for pulmonary embolism (PE) to 41.8% for dyslipidemia. | 26134917 |
| Hypertensive disease, Dyslipidemias, Degenerative polyarthritis | Deregulated Nutrient Sensing | Hypertensive diseases (HTND), dyslipidemia, and osteoarthritis were the three most expensive ORCs at the population level; each responsible for >=$18 million annually among 100,000 individuals. | 26134917 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The mix meal test suggested that APL patients with diabetes had a significant amount of functional pancreatic beta cells, and their diabetes was apparently associated with insulin resistance. | 26139569 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia patterns are differentially associated with dietary factors. | 26140958 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, a strong predictor of cardiovascular diseases, is prevalent among Korean adults, but little is known about the associations between overall lipid profiles and dietary factors. | 26140958 |
| TG gene, CD55 gene, Dyslipidemias | Deregulated Nutrient Sensing | To identify dyslipidemia patterns, factor analysis was used based on total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), triglycerides (TG), and high-density lipoprotein cholesterol (HDLC). | 26140958 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Two dyslipidemia patterns, (1) TC & LDLC and (2) TG & HDLC, were identified. | 26140958 |
| Dyslipidemias | Deregulated Nutrient Sensing | Two dyslipidemia patterns were associated with dietary factors in Korean adults. | 26140958 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | * Insulin resistance was found to be the only significant laboratory predictor of MUO when adjusted for gender, puberty, and the degree of abdominal obesity. | 26141171 |
| Atherosclerosis of renal artery | Deregulated Nutrient Sensing | Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction. | 26141671 |
| Metabolic Diseases | Deregulated Nutrient Sensing | This implies that subjects with an increasing degree of insulin resistance are more likely to not engage in muscular strengthening activity, an exercise modality that has been shown to reduce the risk of several cardiometabolic diseases and improve glycaemic status. | 26141966 |
| Dyslipidemias, Diabetes Mellitus, Congestive heart failure, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Confounding factors affecting ICVA risk were recorded: age, diabetes, hypertension, peripheral vascular disease, dyslipidemia, and congestive cardiac failure. | 26142261 |
| Hyperglycemia, Pyoderma, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | These were localization of the pyogenic process in the larynx, abdominal obesity, fasting hyperglycemia in excess of 8.3 mmol/l, and dyslipidemia accompanied by the reduction in the amount of high density lipoproteins to below 40 mg/100 ml and the increase of low density lipoproteins to above 155 mg/100 ml. | 26145741 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The I148M variant, although increasing the risk of NAFLD, was associated with reduced levels of central adiposity, BMI, serum triglycerides and insulin resistance, suggesting differential roles in fat storage and distribution according to cell types and metabolic status. | 26148225 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Secondary diagnoses: Diabetes Mellitus 64%, high blood pressure 77%, dyslipidemia 52%. | 26150030 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Explaining psychological insulin resistance in adults with non-insulin-treated type 2 diabetes: The roles of diabetes distress and current medication concerns. | 26150327 |
| Anxiety, CTCAE 3.0, Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Psychological insulin resistance may reflect broader distress about diabetes and concerns about its treatment but not general beliefs about medicines, depression or anxiety. | 26150327 |
| Proteinuria, Hypertension, CTCAE, Complications of Diabetes Mellitus, Dyslipidemias | Deregulated Nutrient Sensing | It is also essential to detect early, monitor and manage proteinuria, hypertension and dyslipidemia with good glycemic control to prevent diabetes complications. | 26152133 |
| Fatty Liver | Deregulated Nutrient Sensing | Aging is accompanied by pathophysiological changes including insulin resistance and fatty liver. | 26152236 |
| Congenital Abnormality | Deregulated Nutrient Sensing | On the basis of the well-known key roles of 5'-adenosine monophosphate-activated protein kinase (AMPK) in sensing and regulating the intracellular energy status, we hypothesized that mice with a genetic deletion of AMPK would develop locomotor abnormalities that bear similarity with those detected in the very early disease stage of mice carrying the ALS-associated mutated gene hSOD1(G93A). | 26152932 |
| Amyotrophic Lateral Sclerosis, Molecular Abnormality | Deregulated Nutrient Sensing | Taken together, these data support the concept that altered AMPK function and associated bioenergetic abnormalities could constitute an important component in the early pathogenesis of ALS. | 26152932 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | A Trial of Pitavastatin Versus Rosuvastatin for Dyslipidemia in Chronic Kidney Disease. | 26156625 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Epidemiologic data suggest that low serum 25-hydroxyvitamin D [25(OH)D] increases insulin resistance and the risk of type 2 diabetes. | 26156733 |
| Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | Normal-weight, overweight, and obese adults were considered "healthy" if they had <2 of the following risk factors: low HDL cholesterol, hypertension, high blood glucose, high triacylglycerol, and insulin resistance. | 26156738 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Copeptin, Insulin Resistance, and Risk of Incident Diabetes in Older Men. | 26158609 |
| Friedreich Ataxia | Deregulated Nutrient Sensing | TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. | 26158631 |
| Friedreich Ataxia | Deregulated Nutrient Sensing | We found that genetic reduction in TOR Complex 1 (TORC1) signalling improves the impaired motor performance phenotype of FRDA model flies. | 26158631 |
| Friedreich Ataxia | Deregulated Nutrient Sensing | These results point to the TORC1 pathway as a new potential therapeutic target for FRDA and as a guide to finding new promising molecules for disease treatment. | 26158631 |
| Amyotrophic Lateral Sclerosis, Dyslipidemias | Deregulated Nutrient Sensing | The aim of this study was to examine the prevalence of dyslipidaemia among a cohort of patients with ALS and how the lipid profile of patients with ALS influenced the prognosis. | 26161993 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Interactions with diabetes and insulin resistance may explain divergent findings on how estrogen influences brain volume among older women. | 26163429 |
| Hyperglycemia, Obesity | Deregulated Nutrient Sensing | The mechanism by which maternal obesity leads to these outcomes is not well understood, but maternal hyperglycaemia and insulin resistance are both implicated. | 26165398 |
| Nonalcoholic Steatohepatitis, Non-alcoholic Fatty Liver Disease, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are strongly associated with obesity, insulin resistance, and type 2 diabetes. | 26166101 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is one of the most important independent modifiable risk factors for cardiovascular diseases. | 26168792 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Presence of dyslipidemia was significantly associated with increasing age, smoking status, hypertension, diabetes, and body mass index. | 26168792 |
| Dyslipidemias | Deregulated Nutrient Sensing | High prevalence of dyslipidemia with relative low awareness in Shenzhen was found. | 26168792 |
| Dyslipidemias, Restenosis | Deregulated Nutrient Sensing | In-stent restenosis was associated with younger patient age and with dyslipidemia, long lesion, and stent length. | 26169015 |
| Muscle hypertrophy | Deregulated Nutrient Sensing | Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling. | 26169934 |
| Mucopolysaccharidosis I | Deregulated Nutrient Sensing | Critically, whereas MPS remained unchanged in the UT leg (e.g., ~1.35 +- 0.08%/d), the T leg exhibited increased MPS at 0-3 wk (1.6 +- 0.01%/d), but not at 3-6 wk (1.29 +- 0.11%/d); this was reflected by dampened acute mechanistic target of rapamycin complex 1 signaling responses to RET, beyond 3 wk. | 26169934 |
| Muscle (organ) | Deregulated Nutrient Sensing | Young and lean men from rural India with low birth weight were not observed to have ectopic fat storage in the liver or muscle, and the amount of liver and muscle fat was unrelated to insulin resistance. | 26172248 |
| Choroidal Neovascularization | Deregulated Nutrient Sensing | SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. | 26174951 |
| Primary malignant neoplasm, CC-223 | Deregulated Nutrient Sensing | This phase 1 study investigated the mTORC1/mTORC2 inhibitor CC-223 in patients with advanced cancer. | 26177599 |
| CC-223 | Deregulated Nutrient Sensing | Phosphorylation of mTORC1/mTORC2 pathway biomarkers in blood cells was inhibited by CC-223 >=30 mg/d with an exposure-response relationship. | 26177599 |
| Neoplasms | Deregulated Nutrient Sensing | Preliminary antitumor activity, including tumor regression, and evidence of mTORC1/mTORC2 pathway inhibition were observed. | 26177599 |
| Dyslipidemias, ETV3 wt Allele, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Compared with the controls, the MetS patients showed significantly lower levels of mean strain, mean peak systolic SR and mean peak early diastolic SR (P<0.001 for all), with no difference in the mean peak late diastolic SR. Central obesity, hypertension, dyslipidemia and LV diastolic abnormality were independent risk factors for impaired LA function. | 26178155 |
| Renal Insufficiency, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Hypothyroidism was confirmed to be associated with both dyslipidemia and renal dysfunction. | 26179571 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Low vitamin D status has been associated with an increased risk of developing type 2 diabetes and insulin resistance (IR), although this has been recently questioned. | 26180247 |
| Amyloidosis, Dyslipidemias, Glomerulonephritis | Deregulated Nutrient Sensing | Unknown aspect of the old disease: does dyslipidemia in systemic AA amyloidosis differ from the dyslipidemia in primary glomerulonephritis? | 26181645 |
| Dyslipidemias, Amyloidosis | Deregulated Nutrient Sensing | To investigate the nature of dyslipidemia and its diversity in patients with systemic AA amyloidosis. | 26181645 |
| Dyslipidemias, Amyloidosis | Deregulated Nutrient Sensing | Although the frequency of dyslipidemia was similar in the groups (86.0 vs. 93.4%), patients with systemic amyloidosis had both lower values of LDL-C (4.56 +- 2.05 vs. 5.49 +- 2.23 mmol/L, p = 0.028) and HDL-C (1.19 +- 0.36 vs. 1.35 +- 0.39 mmol/L, p = 0.035). | 26181645 |
| Proteinuria, Dyslipidemias, Amyloidosis | Deregulated Nutrient Sensing | Although dyslipidemia is closely associated with serum total protein, albumin and proteinuria in patients with PG, there is no clear such association in patients with systemic amyloidosis. | 26181645 |
| Dyslipidemias, Amyloidosis, Nephrotic Syndrome | Deregulated Nutrient Sensing | Correlation between serum lipid and hemoglobin levels in this group and other findings point out that probably complex mechanisms take place in dyslipidemia of nephrotic syndrome caused by systemic AA amyloidosis. | 26181645 |
| Glucose Intolerance (disease), Cardiovascular Diseases | Deregulated Nutrient Sensing | HIV-infected patients should be monitored for glucose intolerance, but statins should not be withheld if clinically indicated for cardiovascular disease risk reduction. | 26181706 |
| Acromegaly, physiopathological | Deregulated Nutrient Sensing | In acromegaly visfatin could be considered a useful index of disease activity and metabolic alterations, such as insulin resistance and adipose dysfunction, regardless of the type of treatment. | 26188992 |
| Food Insecurity | Deregulated Nutrient Sensing | Gender differences in the association between food insecurity and insulin resistance among U.S. adults: National Health and Nutrition Examination Survey, 2005-2010. | 26189664 |
| Overweight | Deregulated Nutrient Sensing | Insulin resistance was higher in both normal-weight (P = .001) and overweight or obese (P < .001) women with lower food security, but no linear trend was found in men. | 26189664 |
| Food Insecurity | Deregulated Nutrient Sensing | In women, the association between food insecurity and insulin resistance was no longer significant after adjustment. | 26189664 |
| Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | Food insecurity is associated with insulin resistance in adults without diabetes, and this effect varies by gender in normal-weight and overweight or obese populations. | 26189664 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Improving food security status may help reduce insulin resistance, an underlying risk factor for diabetes and cardiovascular disease. | 26189664 |
| Neurodegeneration due to 3-hydroxyisobutyryl coenzyme A hydrolase deficiency, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. | 26190559 |
| Liver damage, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. | 26190559 |
| Hyperinsulinism, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. | 26190559 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Estimated GFRcr-cys, but not eGFR based on creatinine, was predicted by insulin resistance and hypertension and positively correlated with CVD. | 26194503 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Control of preventable risk factors such as smoking, unhealthy diet, obesity and dyslipidemia should be reinforced at an early age in Bangladesh. | 26197888 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance in heart failure: differences between patients with reduced and preserved left ventricular ejection fraction. | 26198713 |
| Heart failure | Deregulated Nutrient Sensing | Insulin resistance (IR) is a characteristic feature of heart failure (HF) pathophysiology that affects symptoms and mortality. | 26198713 |
| Suicidal behavior, Bipolar Disorder | Deregulated Nutrient Sensing | Insulin resistance and disturbances in glucose and lipid metabolism may be more common in middle-aged depressive patients with suicidal behaviour. | 26199013 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Lower adiponectin levels were related to gender, abdominal obesity, physical activity and insulin resistance and were less influenced by the polymorphisms studied. | 26199115 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | While heavier weight is known to increase the incidence of dyslipidemia, limited data are available on the relationship between weight gain and its development. | 26199305 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that dyslipidemia could be prevented by avoiding weight gain in adulthood. | 26199305 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | To characterize the association between REM-related SDB, glucose intolerance, and insulin resistance in a community-based sample. | 26200994 |
| Glucose Intolerance (disease), Blood Glucose | Deregulated Nutrient Sensing | AHIREM is associated with insulin resistance but not with fasting glycemia or glucose intolerance. | 26200994 |
| Structure of posterior cerebral artery | Deregulated Nutrient Sensing | When stratified by metformin use, IGF-1R remained significantly elevated (P = 0.01) in men with PCa detected whereas p-AMPK (P = 0.05) was elevated only in those without PCa. | 26201966 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Gene polymorphisms related to insulin resistance and gene-environment interaction in colorectal cancer risk. | 26203767 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Insulin resistance (IR) is an established risk factor for colorectal cancer (CRC) and both IR and CRC physiologically overlap. | 26203767 |
| Cardiovascular Diseases, Carotid Intima-Media Thickness, Uterine Fibroids | Deregulated Nutrient Sensing | The aim of this study was to investigate the cardiovascular disease risk of patients with uterine leiomyoma using carotid intima-media thickness (CIMT), insulin resistance and lipid profile. | 26208583 |
| Uterine Fibroids | Deregulated Nutrient Sensing | Uterine leiomyoma was associated with lipid profile, insulin resistance and CIMT in reproductive-aged women. | 26208583 |
| Lung diseases | Deregulated Nutrient Sensing | Moreover, we observed that BET inhibition functionally reversed the pro-inflammatory effect of SIRT1 inhibition in a cellular lung disease model. | 26212199 |
| Muscle, Smooth, Vascular | Deregulated Nutrient Sensing | To date, the impact of endogenous glycogen depletion in vascular smooth muscle and the resultant alterations in cellular energy state (e.g., AMP-activated protein kinase, AMPK) on the contractile response to G protein-coupled receptor agonists (e.g., serotonin, 5-HT) has not yet been studied. | 26212549 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Together, the present findings from clinically-relevant human saphenous vein suggest that the loss of endogenous glycogen in vascular smooth muscle and the resultant accentuation of AMPK phosphorylation by GPCR agonists may constitute a yet another mechanism of metabolic vasodilation of coronary vessels in ischemic heart disease. | 26212549 |
| SLC25A20 gene, Dyslipidemias | Deregulated Nutrient Sensing | High CAC scores were associated with male gender, aging, dyslipidemia, and fasting glucose. | 26213250 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease. | 26214150 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Hence early diagnosis and monitoring of dyslipidemia and treatment of the high risk group with anti hyperlipidemic drugs will help to prevent the incidence of cerebral ischemic stroke thereby reducing morbidity and mortality. | 26215001 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Twenty-one patients (63.6%) had hypertension, 17 (51.5%) dyslipidemia, and 7 (21.2%) had type 2 diabetes or impaired glucose tolerance. | 26215278 |
| Hepatitis C | Deregulated Nutrient Sensing | n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial. | 26216648 |
| Hepatobiliary Disorder, Hepatitis C | Deregulated Nutrient Sensing | Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. | 26216648 |
| Hepatitis C | Deregulated Nutrient Sensing | n-3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients. | 26216648 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A number of peroxisome proliferator-activated receptor (PPAR) a/g dual agonists have been tested for their abilities to attenuate insulin resistance and type 2 diabetes. | 26219845 |
| Dyslipidemias, Diabetes Mellitus, Overweight, Hypertension, CTCAE, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Dyslipidemia often affects overweight and obese adolescents and can be present along with hypertension, insulin resistance, type 2 diabetes, and polycystic ovarian syndrome. | 26219905 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Dyslipidemia in Overweight and Obese School-Aged Children. | 26219905 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | This article is the third of six discussing the comorbidities of childhood obesity and will focus on the individual parts of the lipid profile and the impact of dyslipidemia on the heart and other body systems. | 26219905 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. | 26219912 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Aspirin increased the senescence of CRC cells, increased the protein levels of SIRT1, phospho-AMPK (T172), and phospho-acetyl CoA carboxylase (S79), and reduced the cellular level of ATP. | 26219912 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Small-interfering RNA-mediated downregulation or pharmacological inhibition of SIRT1 or AMPK significantly attenuated the aspirin-induced cellular senescence in CRC cells. | 26219912 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | During the progression of aspirin-induced cellular senescence in CRC cells, SIRT1 showed increased deacetylase activity at a relatively early time point but was characterized by decreased activity with increased cytoplasmic localization at a later time point. | 26219912 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | The role of methotrexate and low-dose prednisolone on adiponectine levels and insulin resistance in patients with rheumatoid arthritis naive to disease-modifying antirheumatic drugs. | 26222244 |
| Refractory anemias, Rheumatoid Arthritis | Deregulated Nutrient Sensing | Insulin resistance (IR) plays an important role in the development of cardiovascular events in rheumatoid arthritis (RA) patients. | 26222244 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Mild Caloric Restriction Decreases Insulin Requirements in Patients With Type 2 Diabetes and Severe Insulin Resistance. | 26222846 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes (T2D) affects ~10% of the US population, a subset of whom have severe insulin resistance (SIR) (>200 units/d). | 26222846 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Cardiovascular risk factors were common: hypertension 31.3% (n = 90), diabetes mellitus 10.5% (n = 29), smoking 21.8% (n = 61), obesity 27.6% (n = 69), dyslipidaemia 22.4% (n = 65), family history 8.5% (n = 24), antiretroviral therapy 12.2% (n = 36). | 26222883 |
| Adenoma | Deregulated Nutrient Sensing | Nonlinear dose responses were observed for AMPK and mechanistic target of rapamycin (mTOR) signaling in mouse adenoma cells, culminating in autophagy and senescence. | 26223300 |
| Kidney Diseases, Lipid Metabolism Disorders | Deregulated Nutrient Sensing | Differences in median total all-cause health care costs observed for diabetes/insulin resistance management (US$14,547 median all-cause health care costs during time periods identified as diabetes/insulin resistance medical events versus US$11,237 without diabetes/insulin resistance events; P=.0021), lipid disorders (US$12,825 versus US$10,033; P=.0004), and renal disorders (US$1389 versus US$0; P<.0001). | 26224690 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Arterial hypertension, insulin resistance, and dyslipidemia is more strongly correlated to waist circumference in boys. | 26226893 |
| Inflammation, Malnutrition | Deregulated Nutrient Sensing | The results of this study suggest that plasma TNF-a is associated with inflammation and insulin resistance in both Japanese elderly men and women, and a prominent association of TNF-a with malnutrition status was observed in elderly women. | 26226964 |
| Dyslipidemias | Deregulated Nutrient Sensing | New Fixed-Dose Combinations of Fenofibrate/Simvastatin Therapy Significantly Improve the Lipid Profile of High-Risk Patients with Mixed Dyslipidemia Versus Monotherapies. | 26227087 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | FDC fenofibrate/simvastatin are effective and well-tolerated therapies to improve the TG and HDLC profile in high-risk patients with mixed dyslipidemia. | 26227087 |
| Dyslipidemias | Deregulated Nutrient Sensing | Residual dyslipidemia according to low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B among statin-treated US adults: National Health and Nutrition Examination Survey 2009-2010. | 26228670 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Despite being on treatment, many persons with dyslipidemia still have suboptimal lipid levels and still experience cardiovascular disease (CVD) events. | 26228670 |
| Dyslipidemias | Deregulated Nutrient Sensing | Despite statin treatment, many persons continue to have residual dyslipidemia with LDL-C, non-HDL-C, and/or apoB levels not being at recommended levels. | 26228670 |
| Dyslipidemias, Diabetic Foot, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | Detections of cardiovascular disease risk factors (dyslipidemia and hypertension) were the indicators with the highest improvement, while non-pharmaceutical treatment and diabetic foot exams showed minor changes. | 26230991 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | This relationship is independent of diabetes, hypertension, dyslipidemia, and body mass index. | 26231617 |
| Dyslipidemias, Have Dizziness, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Serum and urine levels of UCH-L1 were assessed in 125 patients with dizziness, hypertension, type 2 diabetes mellitus, or dyslipidemia. | 26232084 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | After adjustment for obesity, there was no difference in hypertension, dyslipidemia, diagnosed diabetes, or smoking between veteran and non-veteran men. | 26232905 |
| Glucose Intolerance (disease), Malnutrition | Deregulated Nutrient Sensing | We report a case of pancreatolithiasis in which glucose intolerance and malnutrition were significantly improved after starting oral litholysis therapy (OLT) with use of trimethadione. | 26233654 |
| Glucose Intolerance (disease), Malnutrition | Deregulated Nutrient Sensing | In addition, both glucose intolerance and insulin secretion were significantly ameliorated, followed by improvement of malnutrition. | 26233654 |
| Heart failure | Deregulated Nutrient Sensing | Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure. | 26233702 |
| Chemical injury | Deregulated Nutrient Sensing | Sirtuin-1 (SIRT1) is a longevity factor in mammals initiating the cell survival mechanisms, and preventing ischemic injury in heart. | 26233702 |
| Pentalogy of Cantrell | Deregulated Nutrient Sensing | With SIRT1 expression levels, TAS, TOS, OSI, and high density lipoprotein levels in cHF and dHF were determined correlated. | 26233702 |
| Hemorrhage, Dyslipidemias | Deregulated Nutrient Sensing | Gender, dyslipidaemia, prior percutaneous coronary intervention, prior use of acenocoumarol and concomitant coronary artery bypass grafting were found to be predictors for bleeding events. | 26233944 |
| Obesity | Deregulated Nutrient Sensing | Adiponectin is an adipokine which is known to decrease in individuals associated with obesity and insulin resistance. | 26234224 |
| Prediabetes syndrome, Chronic disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with a known state of insulin resistance, including prediabetes and overt diabetes, and individuals with chronic diseases were excluded. | 26234224 |
| Increased insulin level, Hypertensive (finding) | Deregulated Nutrient Sensing | Carotid artery stiffness is related to hyperinsulinemia and insulin-resistance in middle-aged, non-diabetic hypertensive patients. | 26234565 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The study population comprised 2,354 individuals with dyslipidemia (hypertriglyceridemia, hypo-HDL-cholesterolemia or hyper-LDL-cholesterolemia) and 3,106 control individuals. | 26238946 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Additionally, the impact of insulin resistance on metabolic profile can differ by gender and racial group, suggesting that gender-race specific prediction algorithms for diabetes may be warranted. | 26241327 |
| Overweight | Deregulated Nutrient Sensing | Interaction with pBMI was observed in the associations with insulin resistance markers: in offspring of overweight mothers (>=25.0 kg/m2), a 10 nmol/L increase in maternal 25OHD was associated with a 0.007(99%CI:-0.01,-0.001) nmol/L decrease in C-peptide and a 0.02(99%CI:-0.03,-0.004) decrease in HOMA2-IR. | 26244505 |
| Overweight | Deregulated Nutrient Sensing | Thus, intrauterine exposure to both low 25OHD and maternal overweight may be associated with increased insulin resistance in offspring, while exposure to low 25OHD in utero may be associated with increased offspring %BF with no interactive effects from pBMI. | 26244505 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The trial will provide much needed clinical evidence on the impact of vitamin D supplementation on insulin resistance and secretion and its underlying mechanisms, which are relevant for the prevention and management of type 2 diabetes. | 26246241 |
| Heart Diseases, Dyslipidemias, diabetic, Cerebrovascular accident | Deregulated Nutrient Sensing | Analysis also showed that 60.4% were diabetic, 8.9% had a stroke history, 74.3% had dyslipidemia, 69.8% were obese and 30.9% had a history of heart disease. | 26246311 |
| Pancreatic Neoplasm, Neoplasms | Deregulated Nutrient Sensing | Surgically reversible blood glucose dysregulation diagnosed concomitantly with a (peri-) pancreatic tumor appears secondary to compromised liver function due to tumor compression of the common bile duct and the subsequent increase in insulin resistance. | 26248027 |
| Dyslipidemias, Diabetes Mellitus, Hormone abnormality, ovarian neoplasm, Psychiatric, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with comorbidities, such as hypertension, diabetes, hormonal disorders, dyslipidemia and psychiatric conditions, presented a lower chance of having a familial predisposition for ovarian cancer (OR: 0.22; 95% CI: 0.06-0.88; p=0.03). | 26248245 |
| Malignant neoplasm of liver, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance among participants without diabetes at baseline was associated with hepatocellular cancer mortality (HR 4.70; 95% CI 1.55-14.26). | 26250516 |
| Hepatocellular, Prostate carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, and/or insulin resistance among those without diabetes, is a risk factor for gastric, hepatocellular, and prostate cancer in these American Indian communities, although relatively small sample size suggests cautious interpretation. | 26250516 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Our results indicate that metformin intake activates AMPK and consequently suppresses FADS, which leads to reduced levels of the three acyl-alkyl PCs and LDL-C. Our findings suggest potential beneficial effects of metformin in the prevention of cardiovascular disease. | 26251408 |
| Steatohepatitis, Fatty degeneration, Dyslipidemias | Deregulated Nutrient Sensing | Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). | 26252778 |
| Steatohepatitis, Muscle (organ), Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk. | 26252778 |
| Inflammation, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Apoptotic markers and DNA damage are related to late phase of stroke: Involvement of dyslipidemia and inflammation. | 26253215 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | However, little is known about these events and markers in the late stroke (>6 months) and if dyslipidemia could contribute to disease's pathophysiology in a later phase. | 26253215 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Moreover, we observed that stroke patients with dyslipidemia had significantly higher TNF-a, CASP 8 and CASP 3 levels than stroke without dyslipidemia and control groups. | 26253215 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Furthermore, it is plausible to propose that dyslipidemia may contribute to worsen proinflammatory state in a later phase of stroke and an increased risk to new neurovascular events. | 26253215 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | The relatively common TRIB3 Q84R polymorphism (rs2295490) has been associated with abnormal insulin signaling, endothelial dysfunction, insulin resistance, and pro-atherogenic phenotypes. | 26253791 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of major comorbidities in patients undergoing EVAR, including obesity, diabetes, and dyslipidemia, all increased significantly over time. | 26254455 |
| Inflammation, hepcidin | Deregulated Nutrient Sensing | By comparing quartiles of hepcidin levels, systolic blood pressure values in men were significantly higher in the upper quartile of hepcidin vs. the rest of quartiles independently of BMI, chronic inflammation, insulin resistance and other iron markers (ANCOVA, p <0.05). | 26254700 |
| Inflammation | Deregulated Nutrient Sensing | Fatty liver (FL) and abdominal visceral fat (AVF) are strongly associated with systemic inflammation, however, it has not been defined if each one is independently involved, and if the insulin resistance is associated. | 26256894 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | To investigate if FL, AVF and insulin resistance are independently or additively associated with the high-sensitivity C-reactive protein (hs-CRP) in subjects without coronary artery disease we included 491 men and 553 women. | 26256894 |
| Inflammation, Dyslipidemias, Osteoporosis | Deregulated Nutrient Sensing | Inflammation, insulin resistance, dyslipidemia, and glucagon-like peptide-1 (GLP-1) are risk factors for osteoporosis. | 26259132 |
| Inflammation | Deregulated Nutrient Sensing | The mechanisms may be partly explained by the effect of DPP4 on inflammation and insulin resistance. | 26259132 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Experimental studies suggest that a higher intra-cellular ratio of Ca:Mg, which may be induced by a diet high in Ca and low in Mg, may lead to hypertension and insulin resistance. | 26259506 |
| TG gene, Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Even with treatment for hyperglycemia and dyslipidemia, overall levels of fasting blood sugar (FBG, P<0.001), GHbA1c (P<0.001), and triglycerides (TG, P<0.05) in patients with diabetes were still higher than those without diabetes respectively. | 26261612 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Association of NCOA2 gene polymorphisms with obesity and dyslipidemia in the Chinese Han population. | 26261634 |
| Obesity | Deregulated Nutrient Sensing | Insulin resistance and obesity were associated with both definitions. | 26268091 |
| Diastolic dysfunction, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | In multivariable analysis, the presence of diastolic dysfunction on echocardiogram was significantly associated with an abnormal calcium score (OR 13.82, 95% CI 5.57 to 37.37; p < 0.001) after adjusting for Framingham Risk Score or clinical risk factors (age, gender, diabetes mellitus, dyslipidemia, and obesity; OR 19.06,95% CI 4.66 to 107.97; p < 0.001). | 26269148 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X | Deregulated Nutrient Sensing | The liver as central metabolic organ is not only affected by the metabolic syndrome as non-alcoholic fatty liver disease (NAFLD), but may contribute to insulin resistance and metabolic alterations. | 26269425 |
| Total Peripheral Resistance | Deregulated Nutrient Sensing | These results suggest a greater level of peripheral insulin-resistance is associated with decreased cognitive control and working memory. | 26272269 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients. | 26275347 |
| Data types - Address | Deregulated Nutrient Sensing | Sirtuin 1 (Sirt1) serum levels are lower in AD patients and Presenilin 1 (Psen1) is expressed by blood cells. | 26275347 |
| Data types - Address | Deregulated Nutrient Sensing | In conclusion, this study shows that peripheral levels of the potential AD biomarker proteins Bdnf, Sirt1, and Psen1 are not regulated by different promoter methylation. | 26275347 |
| Impaired cognition | Deregulated Nutrient Sensing | Insulin resistance occurring during midlife may increase the risk of cognitive decline later in life. | 26276262 |
| Dyslipidemias, Angina Pectoris | Deregulated Nutrient Sensing | Obese undergoing TX had more dyslipidemia (46% vs. 31%), angina (23% vs. 14%), MI (18% vs. 5%), increased total cholesterol (185 +- 56 vs. 172 +- 48), and triglycerides (237 +- 190 vs. 149 +- 100). | 26277344 |
| Diabetes Mellitus, Non-Insulin-Dependent, physiopathological | Deregulated Nutrient Sensing | Type 2 diabetes is a progressive disease characterized by insulin resistance and insulin secretory dysfunction. | 26278286 |
| B-Lymphocytes, Toxic effect | Deregulated Nutrient Sensing | Environmental factors causing insulin resistance and glucotoxicity may therefore be involved in progressive b-cell failure. | 26278286 |
| Fatty Liver Disease, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Non-alcohol fatty liver disease (NAFLD) is a strong risk factor for insulin resistance and type 2 diabetes. | 26278350 |
| Neoplasm Metastasis, Breast Carcinoma | Deregulated Nutrient Sensing | Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. | 26280894 |
| Neoplasm Metastasis, Breast Carcinoma | Deregulated Nutrient Sensing | We aimed to construct a biomarker-based model that predicts lymph node metastasis in luminal A breast cancer, using expression of silent mating type information regulation 2 homolog 1 (SIRT1) and apoptosis-related factors, which are known to be closely related. | 26280894 |
| Ductal Carcinoma | Deregulated Nutrient Sensing | We selected tissue samples of 278 cases of luminal A invasive ductal carcinoma, constructed tissue microarrays, and performed immunohistochemical staining for SIRT1 and four apoptosis-related proteins. | 26280894 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | Independent factors predictive of lymph node metastasis were pT stage (OR 1.829, p = 0.027), lymphovascular invasion (OR 4.128, p < 0.001), and decreased expression of caspase-3 (OR 0.535, p = 0.034) and of SIRT1 (OR 0.526, p = 0.053). | 26280894 |
| Neoplasm Metastasis, B-Cell Lymphomas | Deregulated Nutrient Sensing | A combination nuclear grade, lymphovascular invasion, increased B-cell lymphoma 2 (Bcl-2) expression, and reduced expression of caspase-3 and of SIRT1 yielded the strongest predictive performance for lymph node metastasis with an area under the curve (AUC) of 0.696. | 26280894 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Our data support a role of SIRT1 protein as tumor suppressor in luminal A breast cancer, in association with apoptosis-related proteins. | 26280894 |
| Demographics Domain | Deregulated Nutrient Sensing | The risk of DM significantly increased with increasing baseline GGT after adjusting for confounders such as BMI, alcohol drinking, 2 hr PG and insulin resistance (2.02[1.35-3.02]; P = 0.001). | 26281475 |
| Hyperglycemia | Deregulated Nutrient Sensing | Isolated hyperglycemia is associated with higher serum concentrations of TGF-b, while a broader phenotype of insulin resistance is associated with higher serum PIIINP. | 26282733 |
| Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | Patients with obesity, dyslipidemia (P < 0.05, respectively), diabetes or hyperuricemia (P < 0.01, respectively) had significantly higher expression of NLRP3. | 26282945 |
| Congenital Abnormality | Deregulated Nutrient Sensing | Elevated cortisol levels and dysregulated insulin-like growth factor binding protein-1 (IGFBP-1; a marker of hepatic insulin sensitivity) are both related to insulin resistance and glucose abnormalities. | 26283275 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | The DF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional b-Cell Mass in Mice. | 26283735 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population. | 26284905 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of hyper LDL-C, hyper TG, and hypo HDL-C were 29.3, 24.2, and 10.2%, respectively, and the overall prevalence of dyslipidemia was 56.5%. | 26292631 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia in Japanese patients with RA is higher than that in the non-RA population. | 26292631 |
| Refractory anemias, Dyslipidemias, Disease | Deregulated Nutrient Sensing | Low-dose atorvastatin was effective for treatment of dyslipidemia in RA patients but had no apparent effect on RA disease activity. | 26292631 |
| Immunoglobulin M, Hyperglycemia | Deregulated Nutrient Sensing | The observed associations of several markers of iron metabolism with hyperglycemia and insulin resistance suggest that iron stores as well as iron-related metabolic pathways contribute to the pathogenesis of IGM and T2DM. | 26294793 |
| Dyslipidemias | Deregulated Nutrient Sensing | PA patients had a higher risk of postoperative new-onset or progressive dyslipidemia. | 26296835 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Compared with the non-hyperuricemia group (n = 170), the hyperuricemia group (n = 254) had a higher prevalence of hypertension (P = 0.013), diabetes mellitus (P = 0.01), dyslipidemia (P = 0.038), atrial fibrillation (P = 0.001), and use of diuretics (P < 0.001). | 26297226 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We explored the prevalence of and risk factors for type 2 diabetes in the adult population of Shanghai (China) with and without dyslipidemia. | 26297334 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The incidences of hypertension, diabetes mellitus, and dyslipidemia were 51.2, 19.4, and 22.2%, respectively. | 26298315 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Thrombospondin 1 (THBS1 or TSP-1) is an adipose-derived matricellular protein, which has recently been highlighted as a potential mediator of insulin resistance and adipose inflammation in obesity. | 26298466 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. | 26298564 |
| Arthritis | Deregulated Nutrient Sensing | However, deletion of SIRT1 aggravated inflammatory arthritis in mice and increased production of pro-inflammatory cytokines in murine macrophages. | 26298564 |
| Refractory anemias | Deregulated Nutrient Sensing | In the current study, we investigated the regulation, expression, and function of SIRT1 in RA, in particular its role in adhesion and proliferation of human RA synovial fibroblasts (RASF). | 26298564 |
| Refractory anemias | Deregulated Nutrient Sensing | We found that expression of SIRT1 was increased in vivo in synovial tissues of RA smokers and in vitro by stimulation of RASF with TNFa, but decreased upon treatment with cigarette smoke extract. | 26298564 |
| Refractory anemias | Deregulated Nutrient Sensing | Synovial tissues of RA smokers showed higher leukocytic infiltration that positively correlated with enhanced levels of SIRT1. | 26298564 |
| Refractory anemias | Deregulated Nutrient Sensing | In conclusion, SIRT1 modulates the proliferative and potentially also adhesive properties of RASF and can therefore promote progression of RA. | 26298564 |
| Refractory anemias | Deregulated Nutrient Sensing | Upregulation of SIRT1 in RA smokers correlates with increased leukocytic infiltration. | 26298564 |
| Inflammation | Deregulated Nutrient Sensing | SIRT1 modulates expression of genes regulating cell adhesion and inflammation. | 26298564 |
| Abnormality of the endocrine system, Thyroid Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of any endocrine abnormality was 58% (dyslipidaemia 43%, glucose intolerance/T2DM 13%, thyroid disorders 15%). | 26300027 |
| Degenerative polyarthritis, Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Association Between Physical Therapy and Risk of Coronary Artery Disease and Dyslipidemia Among Osteoarthritis Patients: A Nationwide Database Study. | 26301384 |
| Degenerative polyarthritis, Dyslipidemias | Deregulated Nutrient Sensing | After adjusting for other potential confounders, the Cox proportional hazards regression analysis showed that patients with OA who received a high PT dosage had a low risk of CAD and dyslipidemia. | 26301384 |
| Degenerative polyarthritis, Dyslipidemias | Deregulated Nutrient Sensing | Patients with OA who received PT had a lower risk of OA-related comorbidities such as dyslipidemia or CAD. | 26301384 |
| Metabolic Syndrome X, Cardiovascular Diseases | Deregulated Nutrient Sensing | Metabolic syndrome is associated with impaired vascular endothelial function, insulin resistance, and increased risk for cardiovascular disease but the underlying mechanisms are not fully elucidated. | 26302093 |
| Blocking | Deregulated Nutrient Sensing | Insulin resistance also did not change following MR blockade (1.04 +- 0.26 vs. 1.38 +- 0.50; P = 0.6). | 26302093 |
| Obesity | Deregulated Nutrient Sensing | Increasing evidence suggests that overnutrition during the early postnatal period, a critical window of development, increases the risk of adult-onset obesity and insulin resistance. | 26302954 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | They had increased visceral fat mass, adult-onset insulin resistance and glucose intolerance as well as elevated serum levels of free fatty acids and triglycerides. | 26302954 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of mixed dyslipidemia and severe hypertriglyceridemia in the Russian population (PROMETHEUS) was undertaken to address this gap. | 26303403 |
| Glucose Intolerance (disease), Hypertension, CTCAE | Deregulated Nutrient Sensing | In a univariate analysis, hypertension, previous IS, glucose intolerance, pulse pressure above median, and presence of moderate to extensive cSVD were associated with the NR phenotype. | 26303791 |
| Arterial Stiffness, Cardiovascular Diseases | Deregulated Nutrient Sensing | Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases. | 26308091 |
| Liver carcinoma, Neoplasm Metastasis | Deregulated Nutrient Sensing | Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A. | 26308575 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | Aberrant mTORC1 signaling is common in hepatocellular carcinoma (HCC), but the underlying mechanism remains elusive. | 26308575 |
| Neoplasm Metastasis, Hyperactive behavior, Malignant Neoplasms, FAM126A gene | Deregulated Nutrient Sensing | We found that Rab1A is frequently overexpressed in HCC, which enhances hyperactive AA-mTORC1 signaling, promoting malignant growth and metastasis of HCC in vitro and in vivo. | 26308575 |
| Malignant neoplasm of liver | Deregulated Nutrient Sensing | Our findings further suggest that Rab1A is a valuable biomarker for prognosis and personalized mTORC1-targeted therapy in liver cancer. | 26308575 |
| FAM126A gene | Deregulated Nutrient Sensing | Because liver is a physiological hub for nutrient sensing and metabolic homeostasis, we investigated the possible role of Rab1A in HCC. | 26308575 |
| Hepatitis C | Deregulated Nutrient Sensing | Clearance of Hepatitis C Virus Improves Insulin Resistance During and After Peginterferon and Ribavirin Therapy. | 26308911 |
| Communicable Diseases, Hepatitis C, Chronic | Deregulated Nutrient Sensing | Patients with chronic hepatitis C virus (HCV) infection are at a greater risk of developing insulin resistance (IR). | 26308911 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | To detect the levels of plasma High-Mobility Group Box-1(HMGB1) in Chinese subject with obesity and type 2 diabetes mellitus (T2DM), and to investigate the correlations between plasma HMGB1 concentration and parameters of body fat, insulin resistance (IR) metabolism and inflammation. | 26317615 |
| Hyperglycemia, Inflammation, Hyperlipidemia, Atherosclerosis | Deregulated Nutrient Sensing | Hyperglycemia, insulin resistance, dislipidemia, oxidative stress and inflammation are well-documented risk factors for subclinical atherosclerosis. | 26318108 |
| Hyperlipidemia, Inflammation | Deregulated Nutrient Sensing | The ORs for insulin resistance, dislipidemia, oxidative stress and inflammation were higher with increasing DPP4 quartiles (P < 0.001 for trend). | 26318108 |
| Vascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Association between CETP gene polymorphism, insulin resistance and risk of diabetes mellitus in patients with vascular disease. | 26318399 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Genetic inhibition of Cholesteryl Ester Transfer Protein (CETP) might be associated with insulin resistance and incident type 2 diabetes mellitus (T2DM). | 26318399 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | This study investigated the relation between a genetic variant in the CETP gene and measures of insulin resistance and incident T2DM in patients with manifest cardiovascular disease (CVD). | 26318399 |
| Vascular Diseases | Deregulated Nutrient Sensing | Presence of CETP SNP rs3764261 is not associated with insulin resistance and incident T2DM in patients with clinically manifest vascular disease. | 26318399 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | BACKGROUND Many renal transplant recipients develop complications such as obesity, posttransplantation diabetes mellitus, and dyslipidemia. | 26319527 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidaemia and low-density lipoprotein cholesterol (LDL-C) target levels were defined according to the Swiss Group for Lipids and Atherosclerosis. | 26321470 |
| Dyslipidemias | Deregulated Nutrient Sensing | In Switzerland, the increase over time in dyslipidaemia prevalence was not paralleled by a similar increase in LLM. | 26321470 |
| Hypothyroidism | Deregulated Nutrient Sensing | A significantly higher TG/HDL-C ratio and lower mean insulin sensitivity ratio observed in men with hypothyroidism, indicated higher insulin resistance in men. | 26323464 |
| FAM126A gene | Deregulated Nutrient Sensing | A novel mutation in SIRT1-AS leading to a decreased risk of HCC. | 26324025 |
| FAM126A gene | Deregulated Nutrient Sensing | SIRT1-AS overexpression promoted the prolife-ration of the human HCC cell lines by upregulating the SIRT1 protein level. | 26324025 |
| FAM126A gene | Deregulated Nutrient Sensing | A single-nucleotide mutation (622U>C) in the SIRT1-AS sequence was found when we used gene sequencing as an assistant approach for HCC diagnosis. | 26324025 |
| FAM126A gene | Deregulated Nutrient Sensing | Moreover, the mean level of SIRT1-AS was much higher in the HCC patients compared to non-hepatopathy volunteers (P<0.01), whereas the opposite effect was observed for the mutant ratio. | 26324025 |
| FAM126A gene | Deregulated Nutrient Sensing | Taken together, we identified a novel mutation in SIRT1-AS leading to a decreased risk of HCC. | 26324025 |
| FAM126A gene | Deregulated Nutrient Sensing | The results of the present study suggest that the 622C mutant of SIRT1 antisense transcript suppresses HCC cell line proliferation, decreases the risk of HCC and is a potential target for gene therapy. | 26324025 |
| Diastolic dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | Effects of Statins on Left Ventricular Diastolic Function in Patients with Dyslipidemia and Diastolic Dysfunction (Stat-LVDF Study). | 26328497 |
| Atherosclerosis, Hua | Deregulated Nutrient Sensing | The long-term effective control of serum uric acid by allopurinol may improve insulin resistance, decrease the serum levels of hs-CRP, reduce the carotid IMT, and may delay the development of atherosclerosis in patients with T2DM and asymptomatic HUA. | 26328636 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our findings suggest that an increased Hb level is a predictor of elevated serum ALT in adolescent girls with dyslipidaemia. | 26328752 |
| Periodontitis, Diabetes Mellitus | Deregulated Nutrient Sensing | Association of periodontitis with insulin resistance, b-cell function, and impaired fasting glucose before onset of diabetes. | 26329671 |
| Periodontitis | Deregulated Nutrient Sensing | Periodontitis and insulin resistance (IR) show bidirectional relationship. | 26329671 |
| Glucose Intolerance (disease), Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | This study investigated the clinicopathologic factors associated with the development of glucose intolerance or overt diabetes mellitus (DM) after distal pancreatectomy, and the correlation between resected pancreas volume and endocrine function impairment. | 26330237 |
| Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Dyslipidemia in HIV Infected Children Receiving Highly Active Antiretroviral Therapy. | 26334860 |
| Lipodystrophy, Dyslipidemias, HIV Infections | Deregulated Nutrient Sensing | Among the children on highly active antiretroviral therapy (HAART), 38.3 % had dyslipidemia and 80.2 % had lipodystrophy, while 25 % antiretroviral therapy (ART) naive HIV infected children had dyslipidemia. | 26334860 |
| Lipodystrophy, Dyslipidemias | Deregulated Nutrient Sensing | No clinically significant risk factors could be identified that increased the risk of dyslipidemia or lipodystrophy in children on highly active antiretroviral therapy (HAART). | 26334860 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The Mitochondrial tRNALeu(UUR) A3302G Mutation may be Associated With Insulin Resistance in Woman With Polycystic Ovary Syndrome. | 26335180 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study. | 26337056 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a well-established risk factor for cardiovascular disease. | 26337056 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Low folate status and homocysteine metabolism gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) may have a synergistic effect increased the incidence of dyslipidemia in Chinese hypertensive population. | 26337056 |
| Hyperglycemia | Deregulated Nutrient Sensing | The results demonstrated that hyperglycemia enhanced HNSCC cell malignancy over time through suppression of cell differentiation, promotion of cell motility, increased resistance to cisplatin, and up-regulation of the nutrient-sensing Akt/AMPK-mTORC1 pathway. | 26337468 |
| Dyslipidemias, Stenosis, Myocardial Ischemia | Deregulated Nutrient Sensing | In patients without organic stenosis, ACh-positive patients (n = 640) were older, had dyslipidemia, and were more likely to have a family history of ischemic heart disease than nonspasm patients (n = 762). | 26337988 |
| Vascular Diseases | Deregulated Nutrient Sensing | GM1 may be an attractive target for the detection, prevention, and therapy of insulin resistance and related vascular diseases, particularly in older people. | 26338710 |
| Dyslipidemias, USF1 wt Allele | Deregulated Nutrient Sensing | Our findings indicate that, in well characterized FCHL individuals, variants in LDLR and LPL provide a small contribution to this dyslipidemia, thus limiting the need for such genetic testing. | 26342331 |
| Nasal Polyps | Deregulated Nutrient Sensing | Thus we hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1-induced EMT. | 26342525 |
| Nasal Polyps | Deregulated Nutrient Sensing | We sought to determine the role of SIRT1 in patients with nasal polyposis. | 26342525 |
| Craniosynostosis | Deregulated Nutrient Sensing | Immunohistochemistry, immunoblotting, and immunoprecipitation were done to evaluate SIRT1, EMT, and hypoxic markers in human nasal epithelial cells or sinonasal tissues from the mice and the patients with CRS with or without NPs. | 26342525 |
| polyps | Deregulated Nutrient Sensing | In addition, resveratrol (a SIRT1 activator) treatment suppressed nasal polypogenesis in WT mice; however, sirtinol (a SIRT1 inhibitor) administration increased the polyp burden in SIRT1 transgenic mice. | 26342525 |
| polyps, Craniosynostosis | Deregulated Nutrient Sensing | In sinonasal specimens from patients with CRS, SIRT1 was downregulated in the mucosa from patients with polyps compared with levels seen in patients without polyps. | 26342525 |
| Exophytic Polypoid Lesion | Deregulated Nutrient Sensing | The intranasal transfection of a small hairpin SIRT1 lentiviral vector induced more nasal polypoid lesions in SIRT1 transgenic mice. | 26342525 |
| Craniosynostosis | Deregulated Nutrient Sensing | Finally, mucosal extracts from patients with CRS without NPs increased SIRT1 expression in nasal epithelial cells, whereas those from patients with CRS with NPs did not. | 26342525 |
| No metabolic abnormalities, Hyperhomocysteinemia, Tyrosine Transaminase Deficiency Disease | Deregulated Nutrient Sensing | However, multiple studies have implicated metabolic abnormalities such as insulin resistance, hormonal deficiencies, and hyperhomocysteinemia. | 26343025 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased serum soluble corin in dyslipidemia: A cross-sectional study. | 26344336 |
| Dyslipidemias | Deregulated Nutrient Sensing | As a physiological activator of natriuretic peptides, corin might also be associated with dyslipidemia. | 26344336 |
| Dyslipidemias | Deregulated Nutrient Sensing | Serum soluble corin was significantly increased in participants with dyslipidemia in both men (P<0.001) and women (P<0.001). | 26344336 |
| Dyslipidemias | Deregulated Nutrient Sensing | After controlling for the confounding factors, OR of dyslipidemia positively increased with increasing levels of serum soluble corin in men (P for trend=0.011) and women (P for trend=0.043). | 26344336 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our findings suggested that serum soluble corin may be a marker or risk factor for dyslipidemia. | 26344336 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Effect of Nasal CPAP on SIRT1 and Endothelial Function in Obstructive Sleep Apnea Syndrome. | 26345325 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | SIRT1 regulates endothelial nitric oxide (NO) synthase, restores NO availability, and is involved in different aspects of cardiovascular disease. | 26345325 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | We also investigated whether or not OSAS patients who received nasal continuous positive airway pressure (CPAP) treatment showed improvements in the levels of SIRT1. | 26345325 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | In the patients with OSAS, the level of SIRT1 in the blood, its activity, and that of NO x was lower than those of normal subjects before nasal CPAP treatment. | 26345325 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Successful treatment for OSAS with nasal CPAP can restore blood levels of the SIRT1 protein and its activity and serum levels of NO x . | 26345325 |
| physiopathological | Deregulated Nutrient Sensing | In regression analysis that adjusted for body mass index, lower plasma PCSK9 strengthened the association of apoB to WAT dysfunction and insulin resistance. | 26350813 |
| Fibrosis Assessment, Dyslipidemias, Hepatomegaly, Wolman Disease | Deregulated Nutrient Sensing | LAL deficiency (LAL D) presents and progresses as a continuum with dyslipidemia, hepatomegaly, and liver fibrosis. | 26350820 |
| Dyslipidemias, Liver Cirrhosis | Deregulated Nutrient Sensing | To improve the understanding of the genetic basis of LAL D, an underappreciated cause of dyslipidemia and cirrhosis, we studied DNA samples from patients with various phenotypes of dyslipidemia. | 26350820 |
| Dyslipidemias, Liver Cirrhosis | Deregulated Nutrient Sensing | We conducted a phase 3 trial of enzyme-replacement therapy in children and adults with lysosomal acid lipase deficiency, an underappreciated cause of cirrhosis and severe dyslipidemia. | 26352813 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The group with the Cross of Andreas developed more glucose intolerance and diabetes than the group without the sign. | 26353100 |
| Increased insulin level | Deregulated Nutrient Sensing | The FII algorithm may be a useful tool for reducing postprandial hyperinsulinemia in T2DM, thereby potentially improving insulin resistance and b-cell function. | 26354547 |
| Blood Glucose, Atherosclerosis | Deregulated Nutrient Sensing | Diurnal salivary cortisol, glycemia and insulin resistance: The multi-ethnic study of atherosclerosis. | 26356041 |
| C5orf38 gene | Deregulated Nutrient Sensing | Compared with 96 controls, patients with LAAS, CEI, and LAC subtypes showed higher levels of white blood cells, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), metalloproteinase 9 (MMP-9), glucose, and iron (p < 0.05); and lower high-density lipoprotein cholesterol (HDL-C) (p < 0.0001); platelets, insulin, insulin resistance, and homocysteine were higher in LAC (p < 0.0001); ferritin was higher in LAAS (p < 0.0001); and total cholesterol (TC) was lower in LAAS and CEI (p < 0.01). | 26359121 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | While the insulin level and insulin resistance rate were higher in reproductive aged PCOS than in healthy women, the difference of these risk factors decreased overtime. | 26360602 |
| Acromegaly, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | The growth hormone (GH) excess displayed in acromegaly induces insulin resistance up to diabetes mellitus (DM). | 26361517 |
| Aneurysm, Dyslipidemias, atherosclerotic, Hypertension, CTCAE | Deregulated Nutrient Sensing | Late aneurysm formation is thought to occur secondary to atherosclerotic degeneration of the SVG with background hypertension and dyslipidaemia accelerating the process. | 26361745 |
| Coronary Stenosis, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We confirmed that severe coronary stenosis was independently associated with both the relative difference in SBP between arms and baPWV, in addition to age, gender, hypertension, dyslipidemia, diabetes mellitus and ankle-brachial index by a logistic regression analysis. | 26362246 |
| Glucose Intolerance (disease), ETV3 wt Allele | Deregulated Nutrient Sensing | Prior to dose adjustment for plasma volume, p value was <0.001 for T1(myo,c) between MetS and non-MetS groups and was 0.13 between subjects with and without glucose intolerance; after adjustment for PV, p value was 0.63 and 0.99. | 26362875 |
| Presenile dementia, Dyslipidemias, Heart failure | Deregulated Nutrient Sensing | Heart failure (HF) is associated with an increased risk of dementia, and studies show that dyslipidemia may be involved in the pathogenesis of dementia. | 26363909 |
| Polycystic Ovary Syndrome, Diabetes Mellitus, Non-Insulin-Dependent, diabetic | Deregulated Nutrient Sensing | Surprisingly low infertility rate in married type 2 diabetic women: A rather curious paradox to the current opinion of insulin resistance as the joint pathogenesis of poly cystic ovary syndrome and type 2 diabetes mellitus. | 26364227 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Sharing the same pathophysiologic principle which is insulin resistance, type 2 diabetes mellitus (T2DM) and poly cystic ovary syndrome (PCOS) are usually considered closely related and easily interchangeable medical entities. | 26364227 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | we would suggest that, despite the well-established fact of insulin resistance as the common pathophysiologic process for T2DM and PCOS, they are definitely separate medical entities. | 26364227 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | As a matter of fact T2DM and PCOS are the two opposite aspect of the insulin resistance coin. | 26364227 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Frequently reported baseline medical conditions were hypertension (45.8%/46.7%) and dyslipidemia (36.4%/60.0%). | 26365276 |
| Dyslipidemias | Deregulated Nutrient Sensing | The rates of CAD risk factors in young adults are high and the most important risk factors are dyslipidaemia, smoking, and overweight/obesity. | 26365941 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | This study aimed to clarify the expression and role of SIRT1 in endometrial carcinoma. | 26367491 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | Because a high-calorie diet was a well-known risk factor for endometrial carcinoma, we first hypothesized that SIRT1 might be downregulated in normal endometrial glandular cells of obese women. | 26367491 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | In contrast, regardless of BMI, the immunohistochemical expression of SIRT1 was significantly higher in endometrial carcinoma (108 cases) than in normal endometria (60 cases) (P<0.05), and its overexpression was associated with a shorter survival (P<0.05). | 26367491 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | Our experiments in vivo revealed that SIRT1 accelerated the proliferation of endometrial carcinoma cell lines (HHUA, HEC151, and HEC1B). | 26367491 |
| Neoplasms | Deregulated Nutrient Sensing | In addition, SIRT1 overexpression in HHUA cells accelerated tumor growth and cisplatin resistance in nude mice, and EX527 significantly suppressed the growth of tumors of HHUA and HEC1B cells. | 26367491 |
| Aggressive behavior, Endometrial Carcinoma, Malignant Neoplasms | Deregulated Nutrient Sensing | In conclusion, SIRT1 is involved in the acquisition of the aggressive behavior associated with endometrial carcinoma, and the SIRT1 inhibitor, EX527, may be a useful agent for the treatment of this malignancy. | 26367491 |
| Endometrial Carcinoma | Deregulated Nutrient Sensing | Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target. | 26367491 |
| Carcinoma of lung | Deregulated Nutrient Sensing | RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors. | 26370156 |
| Carcinoma of lung | Deregulated Nutrient Sensing | The mTORC1/2 inhibitors were significantly more active against RICTOR-amplified lung cancer cells as compared with other agents targeting the PI3K-AKT-mTOR pathway. | 26370156 |
| Neoplasms | Deregulated Nutrient Sensing | The index patient has been treated with mTORC1/2 inhibitors that led to tumor stabilization for more than 18 months. | 26370156 |
| Carcinoma of lung | Deregulated Nutrient Sensing | RICTOR amplification may define a novel and unique molecular subset of patients with lung cancer who may benefit from treatment with mTORC1/2 inhibitors. | 26370156 |
| Eosinophilic disorder | Deregulated Nutrient Sensing | Corticosteroid therapy may be a potent therapeutic strategy for insulin antibody-induced severe insulin resistance with eosinophilia. | 26370863 |
| Dyslipidemias | Deregulated Nutrient Sensing | These patients were significantly older (73 +- 9 vs 65 +- 16 years; P = 0.010), had more often dyslipidemia (79% vs 42%; P = 0.038), more severe AS (peak velocity: 3.9 +- 0.6 vs 3.5 +- 0.6 m/s; P = 0.002), larger indexed left atrial area (10.2 +- 2.5 vs 8.7 +- 1.9 cm(2)/m(2); P = 0.006), and a higher increase in annualized BNP (+90 +- 155 vs +7 +- 49 pg/mL/y; P = 0.010). | 26371385 |
| Degenerative disorder | Deregulated Nutrient Sensing | SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human IVD NP cells, suggesting that rhSIRT1 may be a potent treatment agent for human degenerative IVD disease. | 26373839 |
| Acne | Deregulated Nutrient Sensing | Association between isolated female acne and insulin resistance: a prospective study. | 26373866 |
| Increased insulin level, Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Nowadays hyperinsulinemia and insulin resistance are well-known characteristics of PCOS. | 26373866 |
| Dyslipidemias | Deregulated Nutrient Sensing | Study patients had persistent dyslipidemia despite receiving high-dose statin treatment. | 26374297 |
| Stomach Carcinoma, Atrial Fibrillation by ECG Finding, Dyslipidemias, Ischemic stroke, Hypertension, CTCAE | Deregulated Nutrient Sensing | Independent risk factors of ischemic stroke in gastric cancer patients included age, hypertension, atrial fibrillation, dyslipidemia, and having received major surgery for gastric cancer. | 26376378 |
| Glucose Intolerance (disease), Dyslipidemias | Deregulated Nutrient Sensing | Logistic regression analysis revealed increase of the odds ratios of the WC for glucose intolerance (p<0.001), high blood pressure (p<0.001) and dyslipidemia (p<0.01) in men. | 26376586 |
| Glucose Intolerance (disease), Dyslipidemias | Deregulated Nutrient Sensing | In women, the odds ratios of the WC for glucose intolerance (p<0.01) and dyslipidemia (p<0.001) were significantly increased, and odds ratio of the VAT thickness for high blood pressure (p<0.01) was significantly increased. | 26376586 |
| Dyslipidemias | Deregulated Nutrient Sensing | In contrast, the odds ratio of the VAT thickness was significantly increased only for dyslipidemia (p<0.01) in men. | 26376586 |
| Neoplasms | Deregulated Nutrient Sensing | Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. | 26378060 |
| Neoplasms | Deregulated Nutrient Sensing | We found that both PR and IF inhibit tumor growth and mTORC1 phosphorylation in tumor xenografts. | 26378060 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | Our work represents the first finding that PR may reduce mTORC1 activity in tumors and multiple somatic tissues, and suggest that PR may represent a highly translatable option for the treatment not only of cancer, but also other age-related diseases. | 26378060 |
| Obesity | Deregulated Nutrient Sensing | Whereas insulin resistance and obesity coexist, some obese individuals remain insulin sensitive. | 26378474 |
| Dyslipidemias | Deregulated Nutrient Sensing | This suggests that national strategies in public health be developed to improve the treatments to low-income rural minorities with dyslipidemia. | 26378561 |
| Dyslipidemias | Deregulated Nutrient Sensing | Obese children have increased cardiometabolic risk, including dyslipidemia, insulin resistance and elevated blood pressure. | 26378769 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Higher selenium level has been hypothesized to have the potential to reduce the risk of cardiovascular diseases including dyslipidemia. | 26380972 |
| Dyslipidemias | Deregulated Nutrient Sensing | Our results suggest long-term selenium exposure level may be associated with the risk of dyslipidemia in elderly population. | 26380972 |
| Neurogenic Inflammation | Deregulated Nutrient Sensing | Local angiotensin II (AII) and sirtuin 1 (SIRT1) play a major role in the modulation of neuroinflammation, oxidative stress and aging-related dopaminergic vulnerability to damage. | 26384348 |
| Nerve Degeneration | Deregulated Nutrient Sensing | Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration. | 26384348 |
| Sleep-Disordered Breathing, Diabetes Mellitus | Deregulated Nutrient Sensing | Easily collected symptoms of SDB are strongly associated with insulin resistance and the incidence of type 2 diabetes in older adults. | 26384390 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The VRFs most frequently recognized by patients as their own were stress, hypertension, dyslipidemia, cigarette smoking, and cardiac disease. | 26387042 |
| Prostate Cancer Outcomes Study, Obesity | Deregulated Nutrient Sensing | This may be because obesity and insulin resistance are integral parts of PCOS and are the mechanisms through which PCOS exerts metabolic effects. | 26387977 |
| Adipose tissue loss, Steatohepatitis, Hypertriglyceridemia, Acquired generalized lipodystrophy, LEPTIN DEFICIENCY OR DYSFUNCTION | Deregulated Nutrient Sensing | Acquired generalized lipodystrophy (AGL) is associated with leptin deficiency as a result of adipose tissue loss and hypertriglyceridemia, insulin resistance, and hepatic steatosis. | 26390101 |
| Autoimmune Diseases, Hypertriglyceridemia | Deregulated Nutrient Sensing | Metreleptin therapy is of considerable clinical benefit to reduce insulin resistance and hypertriglyceridemia and did not appear to alter the clinical course of autoimmune disease nor clinical efficacy of immunosuppressive treatments. | 26390101 |
| Obesity | Deregulated Nutrient Sensing | Obesity leads to insulin resistance which subsequently leads to low urinary pH. | 26393903 |
| Nonalcoholic Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and lipotoxicity are pathognomonic in non-alcoholic steatohepatitis (NASH). | 26394161 |
| physiopathological, Toxic effect, Fatty Liver Disease | Deregulated Nutrient Sensing | Liraglutide reduces metabolic dysfunction, insulin resistance and lipotoxicity in the key metabolic organs in the pathogenesis of NASH. | 26394161 |
| Dyslipidemias | Deregulated Nutrient Sensing | In addition, for males, dyslipidemia and prior Ml were moderately strong risk factors. | 26394490 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Adipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance. | 26395744 |
| Obesity | Deregulated Nutrient Sensing | Recent reports indicate that inter/intramuscular adipose tissue (IMAT), composed by adipocytes underneath the deep fascia of the muscles, is positively correlated with aging, obesity and insulin resistance in humans. | 26395744 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | The combination of metabolic control, visceral obesity, and insulin resistance may reasonably predict the degree of liver steatosis in T2DM. | 26398456 |
| Dyslipidemias, Retinal Diseases, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Multivariate models showed that in men, HbA1c>=7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors. | 26399764 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | The effect of two different high-flux dialysis membranes on insulin resistance in non-diabetic end-stage renal disease patients. | 26399977 |
| Electronic Source Report Form | Deregulated Nutrient Sensing | Compared to the PS membrane, PPP high-flux membrane decreased insulin resistance by increasing insulin sensitivity among non-diabetic ESRF patients. | 26399977 |
| Data types - Address | Deregulated Nutrient Sensing | A therapeutic strategy that enhances brain insulin/Igf1 signaling activity to a more robust ApoE2-like phenotype favoring both energy production and amyloid homeostasis holds promise for AD prevention and early intervention. | 26402005 |
| Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin-like growth factor (IGF)-1, through insulin/IGF-1 signaling pathway, is involved in the pathogenesis of type 2 diabetes mellitus (T2DM) and Alzheimer's disease. | 26402757 |
| Inflammation, Glucose Intolerance (disease), Obesity, Hyperlipidemia | Deregulated Nutrient Sensing | Epidemiological evidence indicates an inverse association between nut consumption and obesity, inflammation, hyperlipidaemia and glucose intolerance. | 26404365 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common comorbidities were hypertension (61.3%), diabetes (9.1%), and dyslipidemia (6.9%), and 10.7% were smokers. | 26407512 |
| Dyslipidemias | Deregulated Nutrient Sensing | Specific measures against smoking and sedentary lifestyle, avoidance of advanced stages of immunosuppression, and appropriate treatment of dyslipidemia and dysglicemia are urgently needed to cope with the disease in Brazil. | 26409740 |
| Chronic Obstructive Airway Disease, Hypertension, CTCAE, Kidney Failure, Dyslipidemias | Deregulated Nutrient Sensing | Women were older and had a greater incidence of hypertension, smoking, chronic obstructive pulmonary disease, dyslipidemia, and renal insufficiency. | 26409846 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertension was present in 60.5%, diabetes in 22.5% of patients, 46.5% had dyslipidemia, 18.6% were current smokers, and 45.7% had a family history of cardiovascular disease. | 26412411 |
| Restenosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus is an independent risk factor for restenosis, so reducing insulin resistance is being studied as a new treatment approach. | 26413014 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | Patients were assigned to four groups, AMI without dyslipidemia or DM, with dyslipidemia, with DM and with both dyslipidemia and DM. | 26415345 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | The plasma MDA level was significantly higher (p < 0.001) in patients with both dyslipidemia and DM or with only DM in comparison to patients without dyslipidemia and DM. | 26415345 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus. | 26415345 |
| Dyslipidemias | Deregulated Nutrient Sensing | The increase in AMI incidence in males in the coastal area was associated with an increasing prevalence of dyslipidemia. | 26416407 |
| Dyslipidemias | Deregulated Nutrient Sensing | There were no longer any regional differences observed in AMI incidence, which was considered to be associated with increased dyslipidemia especially in the coastal area. | 26416407 |
| Obesity | Deregulated Nutrient Sensing | Vitamin D and related genetic variants are associated with obesity and insulin resistance. | 26416604 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Mendelian randomization analyses indicate causal roles in PCOS aetiology for higher BMI (P=2.5 x 10(-9)), higher insulin resistance (P=6 x 10(-4)) and lower serum sex hormone binding globulin concentrations (P=5 x 10(-4)). | 26416764 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To explore the effect of full-mouth disinfection (FMD) on glycemic control and insulin resistance in type 2 diabetes mellitus (DM). | 26417619 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Within the limitations of the present study it can be concluded that FMD contributes to significant reduction in insulin resistance, thereby improving the glycemic control in type 2 diabetes mellitus patients. | 26417619 |
| Hypertension, CTCAE, Dyslipidemias, Haiti | Deregulated Nutrient Sensing | According to the current medication and past history, 605 subjects had hypertension (HT), 316 had dyslipidemia (DL), and 182 had type 2 DM. | 26420191 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts. | 26420861 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is a precursor of type 2 diabetes (T2D), and improved risk prediction and understanding of the pathogenesis are needed. | 26420861 |
| Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Comparison between indexes of insulin resistance for risk prediction of cardiovascular diseases or development of diabetes. | 26421364 |
| Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | The predictive effect of various insulin resistance indexes for risk of cardiovascular diseases (CVD) or type 2 diabetes (T2DM) is still unclear. | 26421364 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The Role of Haemoglobin A1c in Screening Obese Children and Adolescents for Glucose Intolerance and Type 2 Diabetes. | 26421782 |
| Dyslipidemias, Osage language | Deregulated Nutrient Sensing | We demonstrated that patients with OSA had a higher percentage of dyslipidemia than subjects without OSA. | 26424733 |
| Dementia, Vascular, Diabetes Mellitus, Non-Insulin-Dependent, physiopathological | Deregulated Nutrient Sensing | Type 2 diabetes mellitus and vascular dementia have common pathological mechanisms for insulin resistance and endothelium dysfunction. | 26427105 |
| Damage | Deregulated Nutrient Sensing | Gender differences in the progression of target organ damage in patients with increased insulin resistance: the LOD-DIABETES study. | 26427534 |
| Dyslipidemias, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Metabolic Dyslipidemia and Risk of Coronary Heart Disease in 28,318 Adults With Diabetes Mellitus and Low-Density Lipoprotein Cholesterol <100 mg/dl. | 26428026 |
| Dyslipidemias, Diabetes Mellitus, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The risk of future coronary heart disease (CHD) in subjects with diabetes and "metabolic dyslipidemia" (high triglyceride [TGs] and low high-density cholesterol levels) remains a matter of concern. | 26428026 |
| Dyslipidemias, Diabetes Mellitus, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Even in subjects with an LDL-C <100 mg/dl, presence of metabolic dyslipidemia in adults with diabetes is associated with an increased risk of CHD. | 26428026 |
| Choline Dehydrogenase, Mitochondrial, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, effective CHD prevention strategies are needed for adults with diabetes and metabolic dyslipidemia. | 26428026 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Associations of pancreatic b-cell function and insulin resistance with microalbuminuria in type 2 diabetes. | 26428073 |
| Microalbuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We investigate the relationships of pancreatic b-cell function and insulin resistance with microalbuminuria in a cross-sectional study of patients with type 2 diabetes. | 26428073 |
| Microalbuminuria | Deregulated Nutrient Sensing | The study suggests insulin resistance is associated with an increased prevalence of microalbuminuria, while improved pancreatic b-cell function is linked to decreased rates of microalbuminuria for those patients. | 26428073 |
| Tumor necrosis | Deregulated Nutrient Sensing | Fasting blood sugar (FBS), insulin, insulin resistance, tumor necrosis factor alpha (TNF-a), and interleukin 6 (IL-6) were measured at baseline and at the end of the study. | 26430826 |
| FBXO8 gene | Deregulated Nutrient Sensing | Means of FBS, insulin, insulin resistance, and IL-6 were significantly different between groups after intervention (p < 0.05), whereas TNF-a was not significantly modified (p > 0.05). | 26430826 |
| Inflammation, Chronic Kidney Diseases, Metabolic Syndrome X | Deregulated Nutrient Sensing | Chronic Kidney Disease in Non-Diabetic Older Adults: Associated Roles of the Metabolic Syndrome, Inflammation, and Insulin Resistance. | 26431218 |
| Partial Wave Spectroscopic Microscopy, Osage language, Dyslipidemias, Diabetes Mellitus, Sleep Apnea, Obstructive, Hypertension, CTCAE | Deregulated Nutrient Sensing | All PWS patients had obstructive sleep apnea (OSA), 62% had dyslipidemia, 43% had hypertension, and 29% had diabetes mellitus. | 26431633 |
| Steatohepatitis, Obesity, Abdominal | Deregulated Nutrient Sensing | Android fat distribution (abdominal obesity) is associated with insulin resistance, hepatic steatosis, and greater secretion of large very low-density lipoprotein (VLDL) particles in men. | 26432801 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The following factors were analyzed: sex, age, surgical access (laparotomy vs. laparoscopy), preoperative BMI, waist circumference (WC), type 2 diabetes mellitus (T2DM), high blood pressure, and dyslipidemia. | 26433591 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Data were adjusted for gender, age, JAK2 mutational status, smoking, dyslipidemia, or hypercholesterolemia requiring drug therapy, antiplatelet therapy, treatment with acetylsalicylic acid, high-sensitive C-reactive protein levels, and absolute monocyte count. | 26437571 |
| Rabson-Mendenhall Syndrome | Deregulated Nutrient Sensing | All these features were compatible with Rabson-Mendenhall syndrome, a rare disorder of severe insulin resistance linked to mutations of insulin receptor. | 26438710 |
| Liver diseases | Deregulated Nutrient Sensing | Previous studies revealed that the common sequence variant I148M in patatin-like phospholipase domain-containing protein 3 (PNPLA3) is associated with liver fat content and liver diseases, but not with insulin resistance. | 26439088 |
| Diabetic care | Deregulated Nutrient Sensing | The AUCs of plasma insulin levels or insulin resistance index (IRI): (AUCs of insulin) x (AUCs of glucose) as the insulin resistance marker were greater in diabetic CAD group than non-diabetic CAD group (insulin, P = 0.0373; IRI, P = 0.0228). | 26439243 |
| TG gene | Deregulated Nutrient Sensing | The AUCs of serum TG or RLP-C levels showed a correlation with the AUCs of plasma insulin (AUC-TG, r = 0.5437, P < 0.0001; AUC-RLP-C, r = 0.6847, P < 0.0001), and they correlated well with the insulin resistance index (AUC-TG, r = 0.7724, P < 0.0001; AUC-RLP-C, r = 0.7645, P < 0.0001). | 26439243 |
| Postprandial hyperlactemia | Deregulated Nutrient Sensing | We found that the insulin resistance showed a close relationship with postprandial hyperlipidemia in CAD patients. | 26439243 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Animal data suggest a role of carnosine supplementation in the prevention and treatment of obesity, insulin resistance, type 2 diabetes and cardiovascular disease but only limited human data exists. | 26439389 |
| Obesity | Deregulated Nutrient Sensing | Increased branched-chain amino acid (BCAA), aromatic amino acid (AAA) and orosomucoid were associated with liver fat accumulation already in its early stage, independent of sex, obesity or insulin resistance (p<0.05 for all). | 26439744 |
| Prostate carcinoma | Deregulated Nutrient Sensing | MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence. | 26439987 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer's Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model. | 26444766 |
| Hypoxia | Deregulated Nutrient Sensing | Furthermore, we found that chronic hypoxia activated AMPK and further inhibited the mTOR signaling pathway, while inhibition of AMPK attenuated autophagy induction through the enhancement of mTOR phosphorylation. | 26444766 |
| Overweight | Deregulated Nutrient Sensing | The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance is Largely Attributable to Central Adiposity in Overweight and Obese Adults. | 26446485 |
| Overweight | Deregulated Nutrient Sensing | Central adiposity drives the association between plasma 25(OH)D and insulin resistance in overweight and obese adults. | 26446485 |
| Degenerative polyarthritis, Osteoporosis, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Most frequent medical problems were depression/anxiety (37%), osteoporosis/osteopenia (26%), hypertension (21%), dyslipidemia (21%), and osteoarthritis (21%). | 26446538 |
| Inflammation, Metabolic Syndrome X | Deregulated Nutrient Sensing | We are first to observe a selective increase in monocyte p38 mitogen-activated protein kinase activity in metabolic syndrome and suggest it as a pivotal molecular target for ameliorating insulin resistance and inflammation. | 26449239 |
| Inflammation, Diabetes Mellitus | Deregulated Nutrient Sensing | Adipose tissue inflammation contributes to the development of complications, such as insulin resistance and type 2 diabetes mellitus. | 26449750 |
| Hypertension, CTCAE, Disorder of circulatory system, Diabetes Mellitus | Deregulated Nutrient Sensing | Recent evidence indicates that resistin may actively participate in the pathophysiology of insulin resistance, diabetes mellitus, hypertension and other circulatory disorders. | 26450098 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors. | 26451383 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | In patients with dyslipidemia, elevated triglyceride (TG) levels, or TG-rich lipoproteins, and cardiovascular risk may remain despite statin therapy. | 26453247 |
| Dyslipidemias, Alcohol abuse, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Patient data, including demographic measures, diagnoses of obesity, diabetes mellitus, dyslipidemia, alcohol abuse, and nicotine dependence were examined. | 26455587 |
| Dyslipidemias, Blood Glucose | Deregulated Nutrient Sensing | Appropriate management of glycemia, blood pressure and dyslipidemia in this population is a major public health concern. | 26455830 |
| Cirrhotic | Deregulated Nutrient Sensing | Moreover, insulin resistance was observed in 82.5% of the cirrhotic patients. | 26457026 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | 26457026 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The MTTP 297 H polymorphism interacted with age, insulin resistance and BMI to decrease serum apoB containing lipoproteins (LDL-C and non-HDL-C) but increase the risk of NAFLD formation. | 26458397 |
| Hypertension, CTCAE, Myopathy, Fatigue | Deregulated Nutrient Sensing | Mifepristone treatment provided rapid improvement in glycemic control, insulin resistance, and hypertension as well as significant diminishment of her myopathy and fatigue. | 26459648 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The prevalence of dyslipidemia, overweight and obesity were 70 %, 33 % and 8 %, respectively. | 26466584 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, Haiti, Hypertension, CTCAE | Deregulated Nutrient Sensing | Many osteoporotics have comorbid diabetes mellitus (DM), hypertension (HT), and dyslipidemia (DL). | 26466937 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In case of insulin resistance, which is typical for type 2 diabetes mellitus (T2DM), proteolysis is increased and protein synthesis is decreased; therefore, we can observe changes in the levels of amino acids in diabetics vs. non-diabetics. | 26467133 |
| B-Lymphocytes, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Type-2 Diabetes (T2D) is characterized principally by insulin resistance in target tissues followed by decreased insulin production due to b-cell failure. | 26469782 |
| Cessation of life, Dyslipidemias, Demographics Domain, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Compared with non-obese DM patients (62% of AMI patients), obese DM patients had: higher incidence of dyslipidemia (31 vs. 24%, P < 0.01); lower incidence of chronic kidney disease (26 vs. 33%) (P < 0.01); higher left ventricular ejection fraction after AMI (53 +- 11 vs. 50 +- 12%, P < 0.001); and lower 2-year cardiac and all-cause death occurrence (0.7 vs. 3.6% and 1.9 vs. 5.2%, both P < 0.01) and cumulative incidence in Kaplan-Meier analysis (P < 0.005, respectively). | 26471283 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Physical activity practices have beneficial health effects on obesity and related disorders such as hypertension and dyslipidemia. | 26474157 |
| Demographics Domain, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Presence of diabetes mellitus (DM), arterial hypertension (AH), dyslipidemia, body mass index > 25 kg/m(2), and daily glucose load > 100 g were associated with NAFLD occurrence. | 26475841 |
| Dysmorphic facies, Dyslipidemias, Anemia, Vitamin B 12 Deficiency | Deregulated Nutrient Sensing | The disorders included dysmorphic anomalies, weight and height deviations, raised thyroid hormone levels, dyslipidaemia, anaemia and vitamin D and B12 deficiency. | 26479250 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia plays a significant role in the progression of cardiovascular disease. | 26481445 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Eradication of HCV has led to improvements in insulin resistance but to date has not been shown to induce remission of diabetes. | 26482468 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | There was a significant increase in the prevalence of glucose intolerance by aging in permanent workers. | 26482960 |
| Microvascular Angina | Deregulated Nutrient Sensing | In Cox proportional hazard models both higher SHBG (Hazard Ratio (HR) 1.012 (95% CI 1.002-1.022), P=0.02) and lower calculated free testosterone (cFT) (HR 0.995 (95% CI 0.993-0.998), P=0.001) were risk factors for all cause mortality independently of age, BMI, presence of macro- and microvascular disease, duration of T2DM, hemoglobin, renal function, insulin use, C-reactive protein and homeostatic model of insulin resistance. | 26483395 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Patients with diabetes mellitus and cardiovascular disease may not achieve adequate low-density lipoprotein cholesterol (LDL-C) lowering on statin monotherapy, attributed partly to atherogenic dyslipidemia. | 26486166 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | In diabetic patients with dyslipidemia, switching from statins to combination ES10/20 therapy generally improved lipoprotein subclass profile and Lp-PLA2 activity more than did statin dose-doubling and was comparable with R10, consistent with its lipid effects. | 26486166 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Insulin resistance plays a crucial role in the etiology of polycystic ovary syndrome (PCOS). | 26486309 |
| Obesity, Abdominal, Prostate Cancer Outcomes Study, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, metabolic disturbance | Deregulated Nutrient Sensing | PCOS is associated with metabolic disturbances such as abdominal obesity, dyslipidemia and type 2 diabetes. | 26486309 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes and insulin resistance have been associated with shortened telomere length. | 26486356 |
| Obesity | Deregulated Nutrient Sensing | Maternal obesity and having telomere shortening were associated with insulin resistance in adult offspring. | 26486356 |
| Dyslipidemias, ETV3 wt Allele | Deregulated Nutrient Sensing | Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia. | 26486974 |
| Dyslipidemias, Dry Eye Syndromes, Degenerative polyarthritis, Rheumatoid Arthritis, Thyroid Diseases, Kidney Failure | Deregulated Nutrient Sensing | With regard to systemic comorbidities, dyslipidemia (AOR: 1.63), degenerative arthritis (AOR: 1.56), rheumatoid arthritis (AOR: 1.44), thyroid disease (AOR: 1.79), and renal failure (AOR: 2.56) were associated with a significantly higher prevalence of dry eye syndrome. | 26488632 |
| Glucose Intolerance (disease), Dyslipidemias, Neoplasms, Cardiovascular Diseases | Deregulated Nutrient Sensing | Complications were comparable between patients with functioning and non-functioning tumors, including the frequencies of glucose intolerance, cardiovascular disease, and dyslipidemia. | 26490049 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Women of Mexican descent are disproportionally affected by obesity, systemic inflammation, and insulin resistance (IR). | 26491126 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Insulin resistance is a characteristic of PCOS patients and is more pronounced in obese patients. | 26491824 |
| Increased insulin level, Acne, Disorder of male reproductive system, Hirsutism, Hyperandrogenism | Deregulated Nutrient Sensing | Insulin resistance and consequent hyperinsulinemia are related to many aspects of the syndrome such as hyperandrogenism, reproductive disorders, acne and hirsutism. | 26491824 |
| Hyperglycemia, Postprandial | Deregulated Nutrient Sensing | Low-dose prednisolone causes insulin resistance that typically manifests as postprandial hyperglycaemia. | 26493042 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Prednisolone-induced insulin resistance is not associated with postprandial vascular dysfunction in patients with rheumatoid arthritis. | 26493042 |
| Cognition, Data types - Address | Deregulated Nutrient Sensing | Cognitive and affective functions, insulin resistance, vascular endothelial function and white matter changes between AD-MetS and AD controls were compared. | 26493280 |
| Dyslipidemias, Myocardial Ischemia, Hepatobiliary Disorder, Heart failure, Cerebrovascular Disorders, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | TB patients with heart failure, ischemic heart disease, cerebral vascular disease, hypertension, dyslipidemia, chronic kidney disease, and liver disease were more likely to associate with DM (ORs=1.27, 1.23, 1.30, 2.32, 3.26, 1.6, and 1.68, respectively) compared to those without the variables. | 26494183 |
| Inflammation | Deregulated Nutrient Sensing | Resistin is an adipocytokine associated with inflammation and insulin resistance. | 26494484 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | Metformin (MF) acts as a tumour-suppressor in renal cell carcinoma (RCC) by inhibiting the AKT/mTOR pathway via AMPK activation. | 26496641 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | It is unclear whether the individual role of hepatic and muscle insulin resistance in the onset of dyslipidaemia is observed in nonalcoholic fatty liver disease (NAFLD) patients and whether this association is mediated through traditional risk factors. | 26496770 |
| diabetic | Deregulated Nutrient Sensing | C18:3n6 and/or D6D (C18:3n6/C18:2n6) were positively associated with insulin resistance and diabetic parameters. | 26497880 |
| Osteoporosis | Deregulated Nutrient Sensing | Denosumab Inhibition of RANKL and Insulin Resistance in Postmenopausal Women with Osteoporosis. | 26498169 |
| glucose metabolism | Deregulated Nutrient Sensing | The aim of our study was to investigate glucometabolic parameters, insulin resistance, and lipid profile in non-diabetic women receiving denosumab. | 26498169 |
| Osteoporotic Fractures | Deregulated Nutrient Sensing | In osteoporotic otherwise healthy postmenopausal women, denosumab was not associated with relevant modification of insulin resistance and lipid profile. | 26498169 |
| Gout, Diabetes Mellitus, Chronic heart failure, Alcohol abuse, Malignant Neoplasms, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | A diagnosis of gout was identified during 2013-2014, with information of diabetes mellitus and insulin resistance, hypertension, chronic heart failure, chronic kidney disease, alcohol abuse, and malignancies. | 26500085 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hypertension, obesity and no exercise, dyslipidemia and high HbA1c in women, and excessive cigarette/alcohol consumption, increased weight, dyslipidemia and high HbA1c in men were crucial. | 26503421 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | They also had a higher prevalence of hypertension (34% versus 25%; p < 0.001), dyslipidemia (79% versus 74%; p < 0.001), and obesity (29% versus 16%; p < 0.001) and a higher Framingham risk score (8% versus 6%; p < 0.001). | 26504260 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cohort of 99 400 patients with diabetes, hypertension, or dyslipidemia in 2007 without a history of cardiovascular disease. | 26505061 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance has been associated with cardiovascular disease in peritoneal dialysis patients. | 26507143 |
| Obesity | Deregulated Nutrient Sensing | The aim of this study was to test whether insulin resistance is associated with obesity parameters, peritoneal transport rate, and glucose absorption. | 26507143 |
| PTPRF gene | Deregulated Nutrient Sensing | A total of 18 patients (35.3%) who had insulin resistance presented with higher LAR and rel.FM (7.3 [12.3, interquartile range] versus 0.7 [1.4, interquartile range], P<0.001, and 39.4 +- 10.1% versus 27.2 +- 11.5%, P=0.002, respectively), lower IGFBP-1 (8.2 +- 7.2 versus 21.0 +- 16.3 ng/ml, P=0.002), but similar glucose absorption and small-solute transport compared with patients without insulin resistance. | 26507143 |
| PTPRF gene, Obesity | Deregulated Nutrient Sensing | Insulin resistance in nondiabetic peritoneal dialysis patients is associated with obesity and LAR independent of glucose absorption and small-solute transport status. | 26507143 |
| Obesity | Deregulated Nutrient Sensing | Fast transport status was not associated with higher likelihood of obesity or insulin resistance. | 26507143 |
| TG gene | Deregulated Nutrient Sensing | TG and UG are therefore novel potential modulators of insulin resistance and may contribute to predict its time-related changes in humans. | 26508327 |
| Metabolic acidosis, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In chronic kidney disease (CKD), dietary acid may promote metabolic acidosis and insulin resistance, which in turn may contribute to adverse clinical health outcomes. | 26508542 |
| Glucose Intolerance (disease), Fibrosis Assessment | Deregulated Nutrient Sensing | Glucose intolerance in cystic fibrosis as a determinant of pulmonary function and clinical status. | 26508676 |
| Hypothyroidism, Hypertension, CTCAE, Kidney Diseases, Obesity | Deregulated Nutrient Sensing | Untreated or sub-clinical hypothyroidism is associated with insulin resistance, obesity, adverse effects on cardiovascular system, hypertension and in turn risk of nephropathy. | 26511212 |
| Dyslipidemias, Albuminuria, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Despite high frequencies of albuminuria (74.8%) and dyslipidaemia (93.0%) among CKD patients, only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. | 26511783 |
| Dyslipidemias, Demographics Domain, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of dyslipidemia was 51.2 % in patients versus 12.1 % in controls (p < 0.001), type 2 diabetes mellitus (DM) was 7.3 versus 17 % (p = 0.292), hypertension was 44 versus 22 % (p = 0.060), and MS was 17 versus 14.6 % (p = 0.957). | 26511949 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | In patients, an association was found between the presence of hypovitaminosis D and the prevalence of dyslipidemia, hypertension and MS and between zIGF-I and the prevalence of hypertension. | 26511949 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension. | 26511949 |
| Dyslipidemias, Hypertension, CTCAE, Somatotropin deficiency | Deregulated Nutrient Sensing | The presence of hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension in GHD patients, suggesting the involvement of both factors in the CV risk in these patients. | 26511949 |
| Dyslipidemias, Endothelial dysfunction, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia, proinflammatory cytokines, endothelial dysfunction signs, and RhoA/Rho-kinase (ROCK) activation are considered risk factors of cardiovascular diseases. | 26512756 |
| Dyslipidemias | Deregulated Nutrient Sensing | The overall prevalence of dyslipidemia in patients was 77.5%. | 26514630 |
| Dyslipidemias, Meibomian gland dysfunction | Deregulated Nutrient Sensing | Dyslipidemia and its association with meibomian gland dysfunction. | 26515235 |
| Dual-affinity B7-H3/CD3-targeted Protein MGD009, Dyslipidemias, Meibomian gland dysfunction | Deregulated Nutrient Sensing | The primary purpose of this study was to determine if there is an association between dyslipidemia and meibomian gland dysfunction (MGD). | 26515235 |
| Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Eye care providers may have a role in discovering undiagnosed dyslipidemia, an important risk factor for cardiovascular illness. | 26515235 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence and Risk Factors Associated with Dyslipidemia in Chongqing, China. | 26516874 |
| Dyslipidemias | Deregulated Nutrient Sensing | The increasing prevalence of dyslipidemia has become a worldwide public health problem, and the prevalence varies widely according to socioeconomic, cultural and ethnic characteristics. | 26516874 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias, Hyperlipidemia | Deregulated Nutrient Sensing | Among the 2009 patients with dyslipidemia, 44.2% had isolated hypertriglyceridemia, 14.7% had isolated hypercholesterolemia, 13.2% had mixed hyperlipidemia, and 28.0% had isolated low high-density lipoprotein cholesterol. | 26516874 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Multivariable logistic regression analysis revealed that dyslipidemia was associated with age, education level, physical activity, obesity and central obesity for both men and women. | 26516874 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | In conclusion, the results indicated dyslipidemia, particularly hypertriglyceridemia and low high-density lipoprotein cholesterol, are very common in Chongqing. | 26516874 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hazard ratios (HR) for insulin resistance, LDL-c, age, sex, and the presence of hypertension were determined in a multivariate analysis. | 26517432 |
| Impaired | Deregulated Nutrient Sensing | Activation of AMP-activated protein kinase (AMPK) suppressed mammalian target of rapamycin (mTOR) pathway, resulting in impaired cancer cell proliferation. | 26520441 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | p-AMPK and p-ACC were frequently inactivated in both cohorts of gastric cancer samples, while p-mTOR, p-S6, and p-4EBP1 were frequently activated in the small cohort of gastric cancer. | 26520441 |
| Endotoxemia | Deregulated Nutrient Sensing | Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia. | 26522327 |
| Sepsis | Deregulated Nutrient Sensing | SIRT1 directly interacted with HMGB1 via its N-terminal lysine residues (28-30), and thereby inhibited HMGB1 release to improve survival in an experimental model of sepsis. | 26522327 |
| Tumor necrosis | Deregulated Nutrient Sensing | By contrast, inflammatory stimuli such as lipopolysaccharide (LPS) and tumor necrosis factor-a promoted HMGB1 release by provoking its dissociation from SIRT1 dependent on acetylation, thereby increasing the association between HMGB1 and chromosome region maintenance 1, leading to HMGB1 translocation. | 26522327 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background. | 26523671 |
| Prostatic Diseases | Deregulated Nutrient Sensing | Complex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease. | 26526283 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Insulin resistance and levels of adipokines in patients with untreated early rheumatoid arthritis. | 26526677 |
| Urinary Incontinence | Deregulated Nutrient Sensing | To investigate the association between insulin resistance (IR) and urinary incontinence in Korean adult women by analyzing the data from the Korea National Health and Nutrition Examination Survey IV (KNHANES) 2007-2009. | 26529410 |
| Hyperinsulinism, Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Insulin resistance (IR) and hyperinsulinaemia are both related to an increased cardiovascular risk, but whether IR predicts coronary heart disease (CHD) independently of other risk factors in patients with type 2 diabetes (T2D) is a topic of considerable controversy. | 26531321 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | We confirmed an increased risk in subjects with dyslipidemia (high density lipoprotein <59 mg/dL: 17.8% of controls, 43.2% of patients, P = 0.0002; low density lipoprotein >130 mg/dL: 26.7% controls, 54.1% patients, P = 0.0002), arterial hypertension (60% controls, 75.7% patients, P = 0.023), and high body mass index (28.9% controls, 70.3% patients, P < 0.0001, and excluded involvement of the selected polymorphisms in RVO. | 26535647 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The average age was 64 years (60-71), mean BMI of 49.6 kg/m2 (38-66), mean follow-up of 5.9 years; 91% of patients were hypertensive, 56% diabetics and 39% had dyslipidemia. | 26537266 |
| Gastro-esophageal reflux disease with esophagitis, Dyslipidemias, Diabetes Mellitus, Sleep Apnea, CTCAE, Hypertension, CTCAE | Deregulated Nutrient Sensing | Comorbidities observed were hypertension (19%), type 2 diabetes mellitus (6.6%), dyslipidemia (7.5%), sleep apnea (16.6%), reflux esophagitis (10%) and orthopedic diseases (7.5%). | 26537277 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Remission of diabetes and dyslipidemia occurred in all patients. | 26537277 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Of the total 1,975 diabetic patients, only 377 (19.1%) were receiving drugs for dyslipidemia. | 26539005 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The percentage of the adolescents and young adults with diabetes mellitus, hypertension, and dyslipidemia were diminished gradually at 6 months postoperatively (P < .001). | 26539837 |
| Eating Disorders, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Re-establishing menstruation is an important goal in the treatment of eating disorders, to avoid dyslipidaemia and the risk of future cardiovascular disease. | 26540134 |
| Dyslipidemias, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects in the 3(rd) tertile of Hcy levels had an accelerated rate of eGFR decline and an increased risk of incident CKD, as compared with those in the 1st tertile, after adjusting for age, gender, baseline diabetes, SBP, BMI, smoking, dyslipidemia, eGFR, folate and vitamin B12 levels. | 26553372 |
| Obesity | Deregulated Nutrient Sensing | Adiponectin level was inversely correlated with age (r = -0.015), parameters of both obesity (R = 0.437;p < 0.001) and insulin resistance (R = 0.374; p < 0.01). | 26554109 |
| Psoriasis | Deregulated Nutrient Sensing | A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis. | 26556603 |
| Inflammatory disorder | Deregulated Nutrient Sensing | Activation of Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, is an unexplored therapeutic approach for treatment of inflammatory diseases. | 26556603 |
| Psoriasis | Deregulated Nutrient Sensing | We randomized 40 patients with moderate-to-severe psoriasis (4:1) to three escalating doses of SRT2104, a selective activator of SIRT1, or placebo. | 26556603 |
| Psoriasis | Deregulated Nutrient Sensing | Given the interesting signals of clinical activity, impact on gene expression and the generally favorable safety profile seen in this study, further investigation of SIRT1 activators for the treatment of psoriasis is warranted. | 26556603 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Excessive cholesterol intake could cause dyslipidemia, which is a major risk factor of coronary artery disease (CAD). | 26556629 |
| Hyperglycemia, Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resistance and systemic inflammation. | 26567860 |
| Non-alcoholic Fatty Liver Disease, physiopathological | Deregulated Nutrient Sensing | Serum leptin seems to have an association with NAFLD both in male and female prediabetic subjects and this association in turn, is mediated by insulin secretory dysfunction and insulin resistance among these subjects. | 26569494 |
| Hyperuricemia | Deregulated Nutrient Sensing | Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. | 26571421 |
| Diabetes Mellitus, Non-Insulin-Dependent, Hyperuricemia | Deregulated Nutrient Sensing | Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. | 26571421 |
| Hyperuricemia | Deregulated Nutrient Sensing | Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance. | 26571421 |
| Inflammation, Hyperuricemia | Deregulated Nutrient Sensing | Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia. | 26571421 |
| Papillary thyroid carcinoma, Percutaneous transhepatic cholangiography | Deregulated Nutrient Sensing | Several reports have shown that insulin resistance is associated with papillary thyroid carcinoma (PTC). | 26573560 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These findings suggest that insulin resistance has a synergistic effect on the obesity-hypertension association in young adults, indicating that the role of adiposity in the development of hypertension is modified by insulin resistance. | 26573703 |
| Hypertensive (finding), Prediabetes syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Hypertensive systolic blood pressure values (p = 0.012), prediabetes (p < 0.001), fatty liver (p < 0.001), and dyslipidemia (p = 0.025) were more prevalent in 15-18-year-old boys than girls. | 26575698 |
| Obesity | Deregulated Nutrient Sensing | The mouse model of monosodium glutamate (MSG)-induced obesity was exploited as a model of obesity combined with insulin resistance. | 26577083 |
| Congenital Abnormality | Deregulated Nutrient Sensing | Suboptimal vitamin B12 (B12) status has been associated with an increased risk of congenital anomalies, preterm birth, and childhood insulin resistance. | 26579949 |
| Muscular Atrophy, Muscle fiber atrophy, Diabetes Mellitus | Deregulated Nutrient Sensing | Muscle fibre atrophy and immunoreactivity for AGEs, Atrogin-1 (a muscle atrophy marker) and phosphorylated AMP-activated protein kinase (AMPK) expressions were markedly increased in human skeletal muscles from patients with diabetes as compared with control subjects. | 26586640 |
| Skeletal muscle atrophy, diabetic | Deregulated Nutrient Sensing | Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. | 26586640 |
| Endurance, Muscular Atrophy, muscle mass, diabetic | Deregulated Nutrient Sensing | Moreover, in diabetic mice we found increased blood AGEs, less muscle mass, lower muscular endurance, atrophic muscle size and poor regenerative capacity, and increased levels of muscle AGE and receptor for AGE (RAGE), Atrogin-1 and phosphorylated AMPK, which could be significantly ameliorated by Ala-Cl. | 26586640 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Fasting insulin and insulin resistance index were greater in women with PCOS. | 26586671 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and associated factors among the hypertensive population from rural Northeast China. | 26589291 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | However, we lack the latest data about the prevalence and epidemiological features of dyslipidemia among hypertensive residents in rural China. | 26589291 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia was dramatically high and dyslipidemia screening was in-need in all diagnosed hypertensive individuals. | 26589291 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of hypertension or dyslipidemia did not impact on survival in patients with diabetes (P > 0.1 for both). | 26589875 |
| Dyslipidemias, Diabetes Mellitus, Heart Diseases, Cerebrovascular accident, Hypertension, CTCAE | Deregulated Nutrient Sensing | A total of 93% were diagnosed with hypertension; 61%, diabetes; and 72%, dyslipidemia; 90% were overweight/obese; 33% had a history of heart disease; and 10% had a stroke. | 26593384 |
| Ulcerative Colitis | Deregulated Nutrient Sensing | Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis. | 26595549 |
| Ulcerative Colitis | Deregulated Nutrient Sensing | Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation is an unexplored therapeutic approach for the treatment of ulcerative colitis (UC). | 26595549 |
| Ulcerative Colitis | Deregulated Nutrient Sensing | Patients with mild to moderately active UC were blindly randomized to 50 mg or 500 mg daily of SRT2104, a selective activator of SIRT1, for 8 weeks. | 26595549 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, patients who were not married, had dyslipidaemia, higher levels of total cholesterol and higher PHQ-9 scores had lower HRQoL. | 26596372 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The binding of AP-1, a heterodimer of c-Jun and c-Fos, is regulated by posttranslational modifications, and in diabetes, deacetylating enzyme, Sirt1, is inhibited. | 26599598 |
| Diabetic Retinopathy, diabetic | Deregulated Nutrient Sensing | In vitro results were validated in the retina from diabetic mice overexpressing Sirt1, and in the retinal microvessels from human donors with diabetic retinopathy. | 26599598 |
| Mitochondrial Damage, Diabetic Retinopathy, Diabetes Mellitus | Deregulated Nutrient Sensing | Thus, in diabetes, due to Sirt1 inhibition, AP-1 is hyperacetylated, which increases its binding at MMP-9 promoter, and hence, activation of Sirt1 could inhibit the development of diabetic retinopathy by impeding MMP-9-mediated mitochondrial damage. | 26599598 |
| Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity as a mediator of the influence of physical activity on insulin resistance in Spanish adults. | 26601643 |
| Depression, CTCAE, Unipolar Depression | Deregulated Nutrient Sensing | Previous studies suggest that insulin-sensitizing agents could play a significant role in the treatment of major depression, particularly depression in patients with documented insulin resistance or those who are resistant to standard psychopharmacological approaches. | 26602230 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Improvement in depression was associated with improvement in glucose metabolism but only in patients with insulin resistance. | 26602230 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Type of dyslipidemia and achievement of the LDL-cholesterol goal in chronic kidney disease patients at the University Hospital. | 26604773 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | This study was conducted to evaluate the types of dyslipidemia affecting patients with CKD stages 3 and 4 and to determine whether these patients achieved LDL-C goal. | 26604773 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | We performed a retrospective chart review of patients with CKD stage 3 or 4 and dyslipidemia who were followed-up at Siriraj Hospital between October 2011 and September 2012. | 26604773 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In total, 150 patients with CKD stage 3 or 4 and dyslipidemia were recruited. | 26604773 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Thus, a developmental plan for the management of dyslipidemia in patients with CKD should be implemented to increase their achievement of the LDL-C goal. | 26604773 |
| Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | Although dyslipidemia is related to the pathogenesis of renal insufficiency, which routinely available lipid measure is more applicable in estimation of kidney function is still uncertain. | 26607500 |
| Lipolysis | Deregulated Nutrient Sensing | However, in the entire cohort fat cell size correlated positively with the ratio of M1/M2 macrophages, TNF-a secretion, lipolysis and insulin resistance. | 26607638 |
| Steatohepatitis, Fatty Liver Disease | Deregulated Nutrient Sensing | Glucagon-like peptide-1 (GLP-1) analogues reduce hepatic steatosis, concentrations of liver enzymes, and insulin resistance in murine models of fatty liver disease. | 26608256 |
| Diabetic Nephropathy, Inflammation | Deregulated Nutrient Sensing | This study was carried out to evaluate the effects of omega-3 fatty acid administration on markers of insulin resistance, lipid concentrations, biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN). | 26611718 |
| Sleeplessness, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Insomnia symptoms were generally not associated with dyslipidemia, but receipt of sleeping pills in the setting of insomnia was associated with elevated LDL-C. Further research is needed to confirm a possible link between sleeping pill use and dyslipidemia and to delineate if an association with atherosclerosis exists with specific types of sleeping pills or with all sedative medications more broadly. | 26612387 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | In addition, the -1031T>C TNFA polymorphism was associated with dyslipidemia in ACS in a Western Mexican population. | 26618233 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Positive association of plasma sCD36 with insulin resistance has been reported, and it has been proposed that sCD36 might represent a marker of macrophage activation and inflammation leading to atherosclerosis. | 26620683 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Immunohistochemical expression of phosphorylated adenosine monophosphate-activated protein (p-AMPK), mitogen-activated protein kinase (p-MAPK), phospho (p)-p70S6K, cyclin E, phosphatase and tensin homolog were analyzed in primary breast cancer samples. | 26623720 |
| Neoplasms | Deregulated Nutrient Sensing | On the other hand, low levels of miR-34a or miR-143 may relieve MDM4 and SIRT1 or MDM2 respectively, which will sequester p53 indicating an indirect mode of p53 suppression in oral tumors. | 26625772 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Intensive management of dyslipidemia in older patients with stable coronary heart disease may have beneficial effects on renal function and SUA. | 26625880 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | High osteoprotegerin (OPG) has been reported in association with insulin resistance and type 2 diabetes. | 26626139 |
| Degenerative polyarthritis, Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Associations with osteoarthritis, cancer, diabetes, dyslipidemia and abnormal sleep duration persisted after adjustment for mental health. | 26627637 |
| Neoplasms | Deregulated Nutrient Sensing | Tumor and non-tumoral tissue samples were collected from all patients, and mRNA expression levels of SIRT1-7 (Sirt1.1, Sirt1.2, Sirt2, Sirt3, Sirt4, Sirt5, Sirt6, and Sirt7) were examined by real-time PCR. | 26631040 |
| Neoplasms | Deregulated Nutrient Sensing | The results showed that expressions of SIRT1.1, SIRT1.2, SIRT4, SIRT5, SIRT6, and SIRT7 mRNAs were unchanged in tumor tissues of BCC patients compared with non-tumoral tissue samples. | 26631040 |
| Prediabetes syndrome, Dyslipidemias | Deregulated Nutrient Sensing | prediabetes and borderline dyslipidemia) was significantly higher in subjects with upper-normal WC on comparison with those with low WC. | 26631437 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We found better control of some risk factors (improved dyslipidemia, heart rate, and blood glucose in patients with diabetes) but worse blood pressure control. | 26631917 |
| ARCN1 gene, Stomach Carcinoma, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia was an independent protective factor for both TB (adjusted HR 2.13, 95% CI 1.73-2.62, P < 0.001) and mortality (adjusted HR 1.11, 95% CI 1.08-1.15, P < 0.001) in gastric cancer patients.Old age, male sex, diabetes mellitus, and COPD were independent risk factors for TB in gastric cancer. | 26632751 |
| Dyslipidemias | Deregulated Nutrient Sensing | Increased Visceral Adipose Tissue Is an Independent Predictor for Future Development of Atherogenic Dyslipidemia. | 26636177 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is frequently observed in persons with a greater amount of visceral adipose tissue (VAT). | 26636177 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, it is still uncertain whether VAT is independently associated with the future development of atherogenic dyslipidemia. | 26636177 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia was defined as one or more abnormalities in high-density lipoprotein (HDL) cholesterol, triglycerides, or non-HDL cholesterol levels. | 26636177 |
| Dyslipidemias | Deregulated Nutrient Sensing | Baseline and change in VAT were independent predictors for future development of atherogenic dyslipidemia. | 26636177 |
| Dyslipidemias | Deregulated Nutrient Sensing | However, BMI, waist circumference, and SAT were not associated with future development of atherogenic dyslipidemia. | 26636177 |
| Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Carotid Artery Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Age, hypertension, dyslipidemia and diabetes are common cardiovascular risk factors (CVRFs) that contribute to the development of atherosclerosis in cardiovascular system including carotid artery disease. | 26636669 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Individual CVRF analysis shows that hypertension was more related to the degree of severity than dyslipidemia and diabetes with corresponding abnormal cIMT rates being 79.39%, 72.98% and 32.37%, respectively. | 26636669 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The percentage of abnormal cIMT in hypertensive patient group with dyslipidemia is significantly higher than the other groups (P< 0.05). | 26636669 |
| Dyslipidemias, Cataract, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The patient's medical history included type II diabetes mellitus, hypertension, chronic kidney disease, dyslipidemia, cataract surgery, and total hip arthroplasty. | 26637513 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Sarcopenia, Obesity | Deregulated Nutrient Sensing | Sarcopenia is associated with significant liver fibrosis independently of obesity and insulin resistance in nonalcoholic fatty liver disease: Nationwide surveys (KNHANES 2008-2011). | 26638128 |
| Fibrosis Assessment, Non-alcoholic Fatty Liver Disease, Sarcopenia, Obesity | Deregulated Nutrient Sensing | Sarcopenia is associated with significant liver fibrosis in subjects with NAFLD, and the association is independent of obesity and insulin resistance. | 26638128 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | These findings suggest that insulin resistance amplifies the association between childhood adiposity and adult MetS and underscore the importance of preventing both adiposity and insulin resistance in early life. | 26640243 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Relationship of Hemoglobin A1c with b Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients. | 26640807 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor. | 26640891 |
| Dyslipidemias, atherosclerotic | Deregulated Nutrient Sensing | An increasing number of epidemiological studies have identified a close relationship between dyslipidemia and atherosclerotic stroke. | 26642713 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | There are few studies available regarding risk factors for specific subtypes of ischemic stroke, and in particular, there is little evidence about the role of dyslipidemia. | 26642713 |
| Obesity, Abdominal, Units Of Measure - Siemens | Deregulated Nutrient Sensing | Lower abdominal obesity (waist circumference) and lower insulin resistance predicted prevalent MHO in male and female adolescents for both definitions (p < 0.01). | 26643813 |
| Reduced Device Function, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Reduced renal function in patients with chronic kidney disease is linked to insulin resistance; and impairments in glucose homeostasis, as measured by HbA1c levels, are related to cardiovascular events. | 26644065 |
| Dyslipidemias, Albuminuria, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Effects of pitavastatin add-on therapy on chronic kidney disease with albuminuria and dyslipidemia. | 26645467 |
| Cardiac complication, Dyslipidemias, Kidney Diseases, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In non-dialysis chronic kidney disease (CKD) patients with dyslipidemia, statin therapy is recommended to prevent cardiovascular complications. | 26645467 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia has been also shown to be an independent risk factor for the progression of CKD. | 26645467 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | This study was a randomized, open-label, and parallel-group trial consisted of a 12-months treatment period in non-dialysis CKD patients with alubuminuria and dyslipidemia. | 26645467 |
| Dyslipidemias, Albuminuria, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Although statin add-on therapy did not show additive renal protective effects, the diet therapy as well as the diet-plus-statin therapy could contribute to the reduction in plasma pentosidine in CKD patients with albuminuria and dyslipidemia. | 26645467 |
| Thoracic Injuries, Traumatic injury | Deregulated Nutrient Sensing | Trauma significantly increased insulin resistance biomarkers, and the NMR spectral profile of the aged flies with trauma-induced thoracic injury resembled that of insulin-resistant chico mutant flies. | 26648055 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Individuals with insulin resistance, but without diabetes, exhibit an increased islet size because of an elevated number of both b and a cells. | 26649619 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Understanding the mechanism(s) that underlies the adaptive response of the islet cells to insulin resistance is a potential approach to design tools to enhance functional b-cell mass for diabetes therapy. | 26649619 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance. | 26650926 |
| Overweight, Obesity | Deregulated Nutrient Sensing | These results suggest that a direct association between mild insulin resistance and brain glucose hypometabolism independent of overweight or obesity can exist in young adults in their 20s. | 26650926 |
| B-Lymphocytes, Hyperglycemia, Postprandial, Hypoinsulinaemia (disorder), GDC Disease Response Terminology | Deregulated Nutrient Sensing | In this cohort of newly diagnosed T2DM subjects, DR is associated with reduced b-cell responsiveness, resulting from b-cell failure rather than insulin resistance, leading to fasting and postprandial hyperglycemia and hypoinsulinemia. | 26652932 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Insulin resistance and glucose intolerance have been associated with increased plasma levels of branched-chain amino acids (BCAA). | 26653072 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Discriminative Ability of Plasma Branched-Chain Amino Acid Levels for Glucose Intolerance in Families At Risk for Type 2 Diabetes. | 26653072 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We determined the discriminative ability of fasting BCAA levels for glucose intolerance in nondiabetic relatives of patients with T2DM of two different ethnicities. | 26653072 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | BCAA levels may serve as biomarkers for early development of glucose intolerance in these families. | 26653072 |
| Endotoxemia, Diabetes Mellitus | Deregulated Nutrient Sensing | The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial. | 26655398 |
| Chronic heart failure | Deregulated Nutrient Sensing | Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure. | 26656612 |
| Carcinogenesis | Deregulated Nutrient Sensing | Adiponectin, a 244-amino acid peptide hormone, is associated with insulin resistance and carcinogenesis. | 26656720 |
| Cessation of life, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is a major risk factor to cardiovascular disease (CVD)--the leading cause of death worldwide. | 26656980 |
| TG gene, Low-Density Lipoproteins, Dyslipidemias | Deregulated Nutrient Sensing | Statin users (n=16,036) had a lower rate of low-density lipoprotein dyslipidaemia compared to non-medication users (3% vs 17%), whereas the prevalence of high-density lipoprotein (HDL) (20% vs 12%) and triglycerides (TG) (12% vs 7%) dyslipidaemia were higher in statin users. | 26656980 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Statin users had a greater prevalence of HDL, TG and combined HDL-TG dyslipidaemia compared to non-medication users (OR 1.44, 95% CI 1.36 to 153), (OR 1.18, 95% CI 1.10 to 1.27) and (OR 1.30, 95% CI 1.22 to 1.38), respectively, (all p values<0.0001). | 26656980 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Among the CVD risk factors, obesity has the greatest effect on the prevalence of all types of dyslipidaemia. | 26656980 |
| Overweight | Deregulated Nutrient Sensing | In fact, in overweight or obese participants, greater ASB consumption was significantly associated with improved indexes of insulin resistance and 2-h postload glucose. | 26661840 |
| Prostate Cancer Outcomes Study, Dyslipidemias | Deregulated Nutrient Sensing | This mutation results in arginine to glutamine substitution at the protein level, while phenotypically this condition presents with a loss of body fat, insulin resistance, dyslipidaemia, and other features mimicking PCOS. | 26662654 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Our case highlights the importance of assessment of adipose tissue distribution, as well as a significance of assessment of glucose tolerance and insulin resistance in the differential diagnosis of PCOS. | 26662654 |
| Neoplasms | Deregulated Nutrient Sensing | Sirtuin-1 (SIRT1), one member of the mammalian sirtuin family, has been suggested to play an essential role in the development and progression of many tumors. | 26662958 |
| Malignant neoplasm of esophagus | Deregulated Nutrient Sensing | However, the relationship between expression of SIRT1 and prognosis of esophageal cancer is still unknown. | 26662958 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | This study aimed to investigate SIRT1 expression and its possible prognostic value in esophageal squamous cell carcinoma (ESCC). | 26662958 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | Western blotting and real-time quantitative reverse transcription PCR (RT-PCR) were carried out to explore the expression of SIRT1 in four human ESCC cell lines, one human normal epithelial cell line, and clinical ESCC tissues. | 26662958 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | Univariate and multivariate Cox regression analyses were performed to evaluate the correlation of SIRT1 expression with clinical features and prognosis of ESCC patients. | 26662958 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | Basal expression levels of SIRT1 protein in ESCC tumor tissues and cell lines were higher than those in the control groups. | 26662958 |
| TNM Staging System, Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | IHC analysis showed that expression levels of SIRT1 protein significantly correlated with TNM stage and lymph node status of ESCC patients. | 26662958 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | High SIRT1 expression in ESCC could serve as an independent predictive biomarker for diagnosis and prognosis in ESCC patients. | 26662958 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma. | 26662958 |
| Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Risk factors for cardiovascular disease included: hypertension, diabetes mellitus (DM), smoking, and dyslipidemia. | 26663649 |
| Dyslipidemias | Deregulated Nutrient Sensing | There was no significant difference of variables between subjects with DM, smoking or dyslipidemia and without cardiovascular risk factors. | 26663649 |
| Vascular Diseases, Obesity | Deregulated Nutrient Sensing | We have found that carotid EMT is associated with cIMT, obesity and insulin resistance and the assessment of carotid EMT may provide additional information concerning early vascular disease. | 26667397 |
| Chronic Kidney Diseases, Dyslipidemias, Dental Plaque, Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Given that multiple interactions were found between CKD stage and age, phosphate, smoking, dyslipidemia, body mass index, systolic BP (SBP), carotid intima-media thickness, plaque at baseline, uric acid, cholesterol, 25-hydroxy vitamin D (25OH vitamin D), and antiplatelet and phosphate binders use, the analysis was stratified by CKD stages. | 26668022 |
| Dyslipidemias, Carotid Intima-Media Thickness, Atherosclerosis | Deregulated Nutrient Sensing | In dialysis, an interaction between body mass index and 25OH vitamin D was found, and age, dyslipidemia, carotid intima-media thickness, low cholesterol, ferritin, and uric acid were positively associated with atheromatosis progression. | 26668022 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally and prevents, or reverses, high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. | 26670557 |
| Steatohepatitis, Non-alcoholic Fatty Liver Disease, Fatty degeneration, Dyslipidemias | Deregulated Nutrient Sensing | Hepatic Steatosis and Insulin Resistance, But Not Steatohepatitis, Promote Atherogenic Dyslipidemia in NAFLD. | 26672634 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Patients with NAFLD had severe insulin resistance, especially at the level of the adipose tissue, when compared with patients without NAFLD. | 26672634 |
| Nonalcoholic Steatohepatitis, Hepatobiliary Disorder, Obesity | Deregulated Nutrient Sensing | We speculate that this lipoprotein profile is driven mostly by liver fat content and insulin resistance and appears not to be worsened by obesity or the severity of liver disease (nonalcoholic steatohepatitis). | 26672634 |
| Steatohepatitis, Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | The objective of the study was to determine the contribution of the severity of steatohepatitis to atherogenic dyslipidemia in patients with NAFLD. | 26672634 |
| Hypertensive disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Older age, higher BMI, diabetes mellitus, and dyslipidemia were associated with having HTN. | 26676023 |
| Dyslipidemias | Deregulated Nutrient Sensing | In fully adjusted models with the 10 covariates, a significantly increased number of infarcted coronary arteries was identified in the highest quartile and quintile of TMAO compared to the lowest quartile (OR 11.9; 95 % CI 3.88-36.7, p <= 0.001) and quintile (OR 14.1; 95 % CI 3.88-51.2; p <= 0.001), respectively, independent of dyslipidemia. | 26676906 |
| Hypertension, CTCAE, Obesity, Chronic active hepatitis | Deregulated Nutrient Sensing | CAH has also been associated with obesity, insulin resistance, and hypertension. | 26677089 |
| ARCN1 gene, Skeletal muscle weakness | Deregulated Nutrient Sensing | Insulin resistance is associated with skeletal muscle weakness in COPD. | 26678022 |
| ARCN1 gene, Skeletal muscle weakness | Deregulated Nutrient Sensing | We tested the hypothesis that insulin resistance contributes to skeletal muscle weakness in people with stable COPD. | 26678022 |
| Quadriceps weakness | Deregulated Nutrient Sensing | On multivariate analysis, with age, sex, weight, BODE index and step count per day included in the model, a one-unit increase in insulin resistance was associated with a 5.9 (2.0-9.8)-kg decrease in QMVC (P = 0.004) and a 4.2 (1.3-14.3)-fold increased risk of quadriceps weakness (P = 0.02). | 26678022 |
| ARCN1 gene, Skeletal muscle weakness | Deregulated Nutrient Sensing | Insulin resistance is associated with skeletal muscle weakness in COPD, independent of potential confounders. | 26678022 |
| Steatohepatitis | Deregulated Nutrient Sensing | Adiposity and insulin resistance explained most of the association of mild hepatic steatosis and partially explained the association of moderate-severe hepatic steatosis with FSH. | 26678239 |
| Dyslipidemias, Retinal Diseases, Kidney Diseases, Obesity | Deregulated Nutrient Sensing | Comorbidities were present more frequently in canagliflozin initiators: nephropathy (10.6% vs. 7.0%), retinopathy (10.4% vs. 7.5%), dyslipidemia (82.4% vs. 72.2%), and obesity (24.9% vs. 15.6%), respectively (P less than 0.001 for all comparisons). | 26679969 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Regression analysis indicated that baseline insulin and glucagon-like peptide-1 use, as well as comorbid dyslipidemia and obesity, were significantly associated with the initiation of canagliflozin versus DPP-4 agents. | 26679969 |
| TG gene, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is the risk factor of cardiovascular disease, but the relationship between the plasma triglyceride (TG) levels and total/cardiovascular mortality has not yet been analyzed in Slavs. | 26680668 |
| physiopathological, "Huntingtons Disease Pathway | Deregulated Nutrient Sensing | AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease. | 26681807 |
| Neurodegenerative Disorders, Vascular System Injuries | Deregulated Nutrient Sensing | Several studies suggested that AMPK activation may improve energy metabolism and protein clearance in the brains of patients with vascular injury or neurodegenerative disease. | 26681807 |
| HD Term Type, "Huntingtons Disease Pathway | Deregulated Nutrient Sensing | However, in Huntington's disease (HD), AMPK may be activated in the striatum of HD mice at a late, post-symptomatic phase of the disease, and high-dose regiments of the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide may worsen neuropathological and behavioural phenotypes. | 26681807 |
| Inflammation, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Among patients with CKD, inflammation, prothrombotic state, oxidative stress, glycated hemoglobin, insulin resistance and alkaline phosphatase are associated with an increased risk of PAD, independent of traditional risk factors. | 26682964 |
| TG gene, Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | It is known to induce central hypothyroidism as well as dyslipidemia including elevation of triglycerides (TG) and low-density lipoprotein cholesterol along with slight lowering of high-density lipoprotein cholesterol (HDL-C). | 26687705 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Several experimental studies showed that magnesium intake improved insulin resistance and glucose uptake in diabetes patients. | 26689794 |
| muscle mass | Deregulated Nutrient Sensing | The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. | 26690705 |
| muscle cell differentiation | Deregulated Nutrient Sensing | We found that expression of a member of the AMPK-related kinase family, the SNF1-AMPK-related kinase (SNARK, also known as NUAK2), increased with muscle cell differentiation. | 26690705 |
| Stanford Cancer Institute, Sarcopenia | Deregulated Nutrient Sensing | After further adjustments for interleukin-6 and insulin resistance, central FM, waist circumference and sarcopenia were no longer significantly associated with SCI. | 26692280 |
| Electrocardiogram: myocardial infarction (finding), Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Comparing pre-CPPT and post-CPPT, we did not find differences regarding age, gender, hypertension, dyslipidemia, diabetes, smoking, previous myocardial infarction, or Killip classification. | 26693879 |
| Skeletal muscle structure, Obesity | Deregulated Nutrient Sensing | Obesity is associated with insulin resistance but not skeletal muscle dysfunction or all-cause mortality. | 26698153 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. | 26698666 |
| Impaired cognition | Deregulated Nutrient Sensing | Clinical studies suggest a link between peripheral insulin resistance and cognitive dysfunction. | 26698666 |
| Alzheimers Disease", Cognition Disorders, Data types - Address | Deregulated Nutrient Sensing | Interestingly, post-mortem analyses of Alzheimer disease (AD) subjects demonstrated insulin resistance in the brain proposing a role for cognitive deficits observed in AD. | 26698666 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | High fat intake and impaired insulin signaling are often associated with obesity, diabetes and insulin resistance. | 26700141 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | However, PFOA, PFNA, and PFUA showed a potential protective effect against glucose intolerance and the risk of diabetes. | 26700417 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Female sex (p < 0.001), advanced age (p = 0.029), lower educational level (p = 0.005), and cardiovascular factors (hypertension, dyslipidemia, diabetes, lack of systemic exercise) also appeared to negatively affect QoL. | 26700441 |
| Fracture, Dyslipidemias, Increased vertebral height | Deregulated Nutrient Sensing | More rapid vertebral height loss was predicted by dyslipidemia (b=0.36, p=.05), previous non-vertebral pathologic fracture related to MM (b=0.51, p=.01), and Durie-Salmon Stage III (b=0.66, p=.06). | 26704858 |
| Amyotrophic Lateral Sclerosis, physiopathological, Diabetes Mellitus | Deregulated Nutrient Sensing | She may have developed diabetes due to SOD1 dysfunction by the I113T SOD1 mutation, and severe insulin resistance induced by ALS. | 26707039 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Statins Are Underutilized in Patients with Nonalcoholic Fatty Liver Disease and Dyslipidemia. | 26707137 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Clinical practice guidelines recommend statins to treat dyslipidemia in patients with NAFLD; however, the extent to which such patients receive statins has not been studied. | 26707137 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | We conducted a structured medical record review to assess for appropriate statin use in patients in a Veterans Administration facility with dyslipidemia and NAFLD as well as a parallel cohort without NAFLD. | 26707137 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Of 255 patients with NAFLD and dyslipidemia, 152 (59.6 %) patients received appropriate statin care. | 26707137 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Statins are underused in patients with NAFLD and dyslipidemia. | 26707137 |
| Obesity | Deregulated Nutrient Sensing | Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults. | 26709969 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Identifying biomarkers will lead to a better understanding of the underlying mechanisms associated with obesity and the pathways leading to insulin resistance (IR) and diabetes. | 26709969 |
| Breast Carcinoma, Obesity | Deregulated Nutrient Sensing | Obesity, insulin resistance, and elevated levels of circulating proinflammatory mediators are associated with poorer prognosis in early-stage breast cancer. | 26712688 |
| Inflammation, Demographics Domain, Degenerative polyarthritis, Obesity, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity is a state of chronic inflammation that is associated with insulin resistance and type 2 diabetes mellitus (DM), as well as an increased risk of osteoarthritis (OA). | 26713606 |
| Degenerative polyarthritis, Demographics Domain | Deregulated Nutrient Sensing | While insulin plays a protective, antiinflammatory role in the synovium, insulin resistance in patients with type 2 DM may impair this protective effect and promote the progression of OA. | 26713606 |
| Cataract | Deregulated Nutrient Sensing | SIRT1 or SIRT1 activators could potentially be used to prevent ocular aging and cataract in the future. | 26716364 |
| Coronary Artery Disease, Restenosis | Deregulated Nutrient Sensing | The obesity-related hormones leptin and adiponectin are independently and oppositely associated with insulin resistance, which is an important risk factor for coronary artery disease (CAD) and restenosis after coronary intervention. | 26717211 |
| ARCN1 gene, Cardiovascular Diseases, Dyslipidemias, Behavior Disorders, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | It is important to screen patients at risk for COPD among those with lifestyle-related diseases such as hypertension, diabetes mellitus, and dyslipidemia, since these diseases promote the development of cardiovascular diseases closely associated with increased COPD mortality. | 26718143 |
| Neoplasms | Deregulated Nutrient Sensing | Adenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that maintains energy homeostasis in both normal and cancerous cells, and has emerged as a tumor suppressor. | 26718214 |
| Breast Carcinoma | Deregulated Nutrient Sensing | LKB1/AMPK inhibits TGF-b1 production and the TGF-b signaling pathway in breast cancer cells. | 26718214 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Taken together, our study demonstrates that AMPK exerts multiple actions on TGF-b signaling and supports that AMPK can serve as a therapeutic drug target for breast cancer. | 26718214 |
| Myeloid Leukemia, Chronic | Deregulated Nutrient Sensing | Here, we report that Sirtinol, a known SIRT1 inhibitor, induces premature senescence and growth arrest in K562 CML cells. | 26718407 |
| Acne | Deregulated Nutrient Sensing | Postadolescent male patients with acne more commonly have insulin resistance. | 26720707 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes is usually accompanied by dyslipidaemia, and among these triglyceride levels are related to the insulin resistance in type 2 diabetes. | 26721018 |
| Hyperglycemia | Deregulated Nutrient Sensing | Recent evidence suggests that Gal-3 may also be an important modulator of cardiometabolic traits such as adiposity, insulin resistance, and hyperglycemia. | 26722123 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | These findings implied that there was a certain degree of insulin resistance and abnormal glucose metabolism in the patients with liver cirrhosis. | 26722544 |
| Hypertension, CTCAE, Dyslipidemias, Prediabetes syndrome | Deregulated Nutrient Sensing | VAT was associated with increased risk of hypertension (OR = 1*97, P < 0*0001), prediabetes (OR = 1*53, P = 0*0007) and dyslipidaemia (OR = 2*40, P < 0*0001). | 26725580 |
| Hypertension, CTCAE, Dyslipidemias, Prediabetes syndrome | Deregulated Nutrient Sensing | Higher VAT was associated with increased risk of hypertension, dyslipidaemia and prediabetes. | 26725580 |
| Obesity | Deregulated Nutrient Sensing | Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity. | 26727116 |
| TG gene | Deregulated Nutrient Sensing | Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated. | 26727147 |
| TG gene | Deregulated Nutrient Sensing | These results suggest that changes in TG and SUA are synergistic factors associated with changes in insulin resistance after a 12-week walking exercise program in community-dwelling older women. | 26727147 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Subjects with lower BNP quartiles had significantly elevated prevalence of dyslipidemia, including hypertriglyceridemia, hyper-LDL-emia and hypercholesterolemia. | 26728801 |
| Dyslipidemias | Deregulated Nutrient Sensing | The elderly people with higher BNP levels have significantly reduced risks for nonfasting dyslipidemia. | 26728801 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Psychological Insulin Resistance in Patients with Type 2 Diabetes. | 26731825 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To identify risk factors associated with psychological insulin resistance (PIR) in Indian type 2 diabetes (T2DM) population. | 26731825 |
| Nonalcoholic Steatohepatitis, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | These results may evidence that non-alcoholic steatohepatitis is associated with metabolic risk factors such as diabetes mellitus, dyslipidemia, and obesity. | 26732004 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with diabetes mellitus and dyslipidemia had higher BMI values. | 26734799 |
| Impaired cognition, Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Some differences in comorbidities were noted, with diabetes mellitus, dyslipidaemia, chronic renal failure and atrial fibrillation being more frequent in the RICA registry while cognitive and functional impairment predominated in the EAHFE registry. | 26739849 |
| Overweight | Deregulated Nutrient Sensing | Relative Contribution of Intramyocellular Lipid to Whole-Body Fat Oxidation Is Reduced With Age but Subsarcolemmal Lipid Accumulation and Insulin Resistance Are Only Associated With Overweight Individuals. | 26740597 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease | Deregulated Nutrient Sensing | Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease. | 26743526 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum Levels of Osteocalcin and Insulin Resistance in Patients with Impaired Glucose Tolerance or New-Onset Diabetes Mellitus After Liver Transplantation. | 26743527 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | An altered prenatal environment during maternal obesity predisposes offspring to insulin resistance, obesity, and their consequent comorbidities, type 2 diabetes and cardiovascular disease. | 26744506 |
| Weight Gain, Endotoxemia | Deregulated Nutrient Sensing | The gut microbiota plays an important role in human metabolism; previous studies suggest that the imbalance can cause a metabolic endotoxemia that may be linked to weight gain and insulin resistance. | 26745497 |
| Dyslipidemias, Blood Glucose | Deregulated Nutrient Sensing | This feature is attributable to a greater discrimination of patients with high blood pressure, glycemia, and dyslipidemia. | 26747228 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The risk factors for CAS were identified to be advanced age, history of smoking, diabetes mellitus, dyslipidaemia and presence of a carotid bruit. | 26750678 |
| Arthritis, Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Patients with late onset arthritis (LOA) were more likely to have DM (OR 4.0, P=0.009), hypertension (OR 2.5, P=0.004), dyslipidemia (OR 2.3, P=0.011), and obesity (OR 1.7, P=0.012). | 26750761 |
| Weight decreased | Deregulated Nutrient Sensing | HDL-sphingomyelin reduction after weight loss by an energy-restricted diet is associated with the improvement of lipid profile, blood pressure, and decrease of insulin resistance in overweight/obese patients. | 26751808 |
| Back Pain | Deregulated Nutrient Sensing | Our results indicated that SIRT1 exerted anti-inflammatory effects againstIL-1b-mediated degeneration of NP cells through the TLR2/SIRT1/NF-kB pathway, suggesting that it could be used as a potential candidate for treating IVDD-mediated back pain. | 26752489 |
| Primary malignant neoplasm, Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Childhood cancer survivors treated with haematopoietic stem cell transplantation (HSCT) and total body irradiation are at an increased risk of developing diabetes early in life due to insulin resistance and b-cell dysfunction, but the optimal screening method is unknown. | 26757409 |
| Dyslipidemias, Diabetes Mellitus, Sleep Apnea, Obstructive, Comorbidity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Comorbidity improvement and resolution were 98 % for obstructive sleep apnea, 79 % for diabetes mellitus, 87 % for dyslipidemia, and 85 % for hypertension. | 26757919 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is a known risk factor for developing cardiovascular disease. | 26758706 |
| Cessation of life, Dyslipidemias | Deregulated Nutrient Sensing | In addition to traditional predictors of in-hospital death, statin-treated dyslipidemia was a favorable predictor of in-hospital mortality for STEMI and NSTEMI patients, whereas hemodialysis was the strongest predictor for NSTEMI patients. | 26758733 |
| Increased insulin level, Thyroid carcinoma | Deregulated Nutrient Sensing | Studies to investigate the specific effects of hyperinsulinemia and insulin resistance on thyroid cancer risk may provide additional information. | 26760177 |
| ACSM3 gene, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of sedentary lifestyle was 44%, history family 50%, smoking 23%, overweight/obesity 68%, dyslipidemia (high cholesterol levels) 43%, SAH 40%, and diabetes 11%. | 26761368 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | When compared to the 2002 study, the prevalence of active smoking and sedentary behavior decreased, whereas the prevalence of hypertension, dyslipidemia and obesity increased. | 26761368 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hypertension, obesity and dyslipidemia are still prevalent and require major prevention programs. | 26761368 |
| Demographics Domain, Cardiovascular Diseases, Dyslipidemias, Haiti, Diabetes Mellitus, Hyperuricemia, Hua , Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | To clarify the association between toothbrushing and risk factors for cardiovascular disease--namely, hypertension (HT), diabetes mellitus (DM), dyslipidaemia (DL), hyperuricaemia (HUA) and chronic kidney disease (CKD). | 26769787 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM). | 26770991 |
| Dyslipidemias, Glaucoma, CTCAE | Deregulated Nutrient Sensing | We aimed to investigate the links between oxidative stress (OS), HDL-related antioxidant enzyme activities and dyslipidemia in distinct subtypes of glaucoma. | 26773174 |
| Diabetes Mellitus, Non-Insulin-Dependent, metabolic disturbance | Deregulated Nutrient Sensing | Skeletal muscle insulin resistance and oxidative stress are characteristic metabolic disturbances in people with type 2 diabetes. | 26774673 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Findings implicate AA supplementation as a potentially inexpensive, convenient, and effective adjunct therapy in the treatment of insulin resistance in people with type 2 diabetes. | 26774673 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Patients with PLL had poor metabolic control and marked insulin resistance compared to subjects with type 2 diabetes. | 26776282 |
| Lipodystrophy, Flinders medical centre-7 marker, Diabetes Mellitus | Deregulated Nutrient Sensing | Our data suggests that PLL is a relatively common form of lipodystrophy in diabetes clinics, which is associated with poor metabolic control and marked insulin resistance. | 26776282 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance is common in individuals with chronic kidney disease (CKD) and may be partly explained by modifiable risk factors. | 26776598 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | We here explore the potential role of vitamin E as a modifiable risk factor for insulin resistance among individuals with CKD. | 26776598 |
| Obesity | Deregulated Nutrient Sensing | Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. | 26777475 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | These patients were older (69.5y vs. 64.2y; p<0.001), more frequently male, with more risk factors (hypertension, dyslipidemia), and more comorbidities. | 26778745 |
| Non-alcoholic Fatty Liver Disease, Fatty degeneration | Deregulated Nutrient Sensing | Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. | 26780287 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Recent data in mice have identified de novo ceramide synthesis as the key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in liver fat due to IR ('Metabolic NAFLD' but not that due to the I148M gene variant in PNPLA3 ('PNPLA3 NAFLD'). | 26780287 |
| Triglycerides, Dyslipidemias | Deregulated Nutrient Sensing | Hypertriacylglycerolaemia is a hallmark of diabetic dyslipidaemia with increased concentrations of triacylglycerol (TG)-rich VLDL1 particles. | 26781548 |
| Hyperleucinemia, Hyperinsulinism | Deregulated Nutrient Sensing | Hyperinsulinaemia and insulin resistance (but not hyperleptinaemia) are associated with augmented pressure response from chemoreceptors. | 26781642 |
| Dyslipidemias, Psoriasis | Deregulated Nutrient Sensing | To our knowledge this study for the first time unveils that high level of intracellular cholesterol plays a crucial role in IL-17A signaling in keratinocytes and may explain the strong association between psoriasis and dyslipidemia. | 26781963 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Accumulating evidence has linked elevated parathyroid hormone (PTH) with insulin resistance, beta cell dysfunction and dysglycaemia, however, its role in the development of diabetes is largely unclear, particularly among non-whites. | 26782010 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Relative risks ranged from 1.07 (0.84-1.36) for having dyslipidemia to 4.65 (1.77-12.17) for having hypertension. | 26782636 |
| Psoriasis, Dyslipidemias, Anemia, Asthma, Hypertension, CTCAE, Eczema | Deregulated Nutrient Sensing | The age-standardised prevalence of hypertension, dyslipidaemia, asthma, psoriasis, eczema and anaemia was significantly higher in the MS cohort compared to that in the general Australian population. | 26784322 |
| Dyslipidemias | Deregulated Nutrient Sensing | The level of disability (Multiple Sclerosis Severity Score) in those who reported overweight/obesity (b: 0.76 (95% CI 0.04-1.48), p = 0.037), or dyslipidaemia (b: 1.05 (95% CI 0.07-2.02), p = 0.036) was significantly higher compared to those who did not report these comorbidities, even after adjustment for potential confounders. | 26784322 |
| Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, diabetes, smoking, previous coronary artery disease and stroke were similar between the groups. | 26786608 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Type 2 diabetes is the most common form of diabetes some investigations show the association of lipoprotein-associated phospholipase A2 mass and activity with the incidence of cardiovascular disease (CVD) in populations with high prevalences of insulin resistance and diabetes. | 26786990 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease. | 26788516 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Statins are prescribed to treat dyslipidemia (abnormal amount of lipids such as cholesterol and/or fat in the blood) and reduce cardiovascular disease (CVD) risk. | 26788719 |
| Weight Gain | Deregulated Nutrient Sensing | EMPOWIR (Enhance the Metabolic Profile of Women With Insulin Resistance; NCT00618072) was a double-blind, placebo-controlled, 12-month trial of women with >20-pound weight gain, normal glucose tolerance test, and increased area-under-the-curve insulin. | 26789348 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, serum irisin was inversely related to pre-diabetes/type 2 diabetes (T2D) independent of other risk factor for T2D and insulin resistance [OR (95 % CI); 0.66 (0.49-0.90), P = 0.009]. | 26790404 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Participants presented a high prevalence of diabetes (18.5%), dyslipidemia (17.6%), gout/hyperuricemia (10.7%), overweight/obesity (68.8%), self-medication (37.5%), and alcohol consumption (33.3%). | 26791352 |
| Glucose Intolerance (disease), ETV3 wt Allele | Deregulated Nutrient Sensing | Among the components of MetS, over waist circumference and glucose intolerance were significantly associated with increased incidence of the composite endpoint (HR 1.23, P=0.038, and HR 1.29, P<0.001, respectively) in males but not in females. | 26794282 |
| Inflammation, Dyslipidemias, Overweight | Deregulated Nutrient Sensing | This study is a preliminary clinical study to verify that GO could be beneficial for amelioration of obesity-related dyslipidemia, inflammation, and oxidative stress without side effect in the overweight or obese subjects. | 26796927 |
| Decompensation, Diabetes Mellitus | Deregulated Nutrient Sensing | In compensated HCV-related cirrhotic patients, diabetes and marked insulin resistance are independently associated with poorer overall survival and increased risk of hepatic decompensation. | 26797261 |
| Renal Insufficiency, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Impaired renal function causes dyslipidemia that contributes to elevated cardiovascular risk in patients with chronic kidney disease (CKD). | 26799206 |
| Dyslipidemias, Diabetes Mellitus, Retinal Diseases, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Twenty-one (91.3%) patients had the following systemic diseases: hypertension, diabetes mellitus without retinopathy, dyslipidemia, or chronic renal failure requiring dialysis. | 26800210 |
| Multiple Myeloma, Waldenstrom Macroglobulinemia, Adult Non-Hodgkin Lymphoma | Deregulated Nutrient Sensing | TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenstrom's macroglobulinemia. | 26800393 |
| Endothelial dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Endothelial dysfunction is linked to insulin resistance, inflammatory activation, and increased cardiovascular risk in diabetes mellitus; however, the mechanisms remain incompletely understood. | 26800561 |
| Endothelial dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Our findings demonstrate that noncanonical Wnt5a signaling and JNK activity contribute to vascular insulin resistance and endothelial dysfunction and may represent a novel therapeutic opportunity to protect the vasculature in patients with diabetes mellitus. | 26800561 |
| Prediabetes syndrome, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance: The linchpin between prediabetes and cardiovascular disease. | 26802220 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | It has been suggested that insulin resistance may contribute to the increased risk of EC in PCOS. | 26802879 |
| Dyslipidemias, Diabetes Mellitus, Heart failure, Chronic lung disease, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Compared with cases performed from 2005 to 2006, CS-AMI patients receiving PCI from 2011 to 2013 were more likely to have diabetes, hypertension, dyslipidemia, previous PCI, dialysis, but less likely to have chronic lung disease, peripheral vascular disease, or heart failure within 2 weeks (p < 0.01). | 26803418 |
| Inflammation, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia and low-grade inflammation are integral in the pathogenesis of atherosclerosis. | 26803431 |
| Dyslipidemias | Deregulated Nutrient Sensing | These results suggest that checking for the presence or absence of resistance factors, including elevated HbA1c levels and dyslipidemia, may contribute to the appropriate usage of SITA. | 26804641 |
| Glucose Intolerance (disease), Pancreatic Fistula | Deregulated Nutrient Sensing | Postoperatively, the patient had no complications such as pancreatic fistula or aggravation of glucose intolerance. | 26805362 |
| Dyslipidemias, ETV3 wt Allele, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | Dyslipidemia is an important factor in MetS and is related to atrial fibrillation (AF). | 26805814 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Correlation between non-alcoholic fatty liver disease (NAFLD) and dyslipidemia in type 2 diabetes. | 26810159 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia in patients with NAFLD is atherogenic in nature and it is characterized by increased levels of serum triglycerides and decreased levels of HDL cholesterol. | 26810159 |
| Weight decreased | Deregulated Nutrient Sensing | Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women. | 26811166 |
| Weight decreased | Deregulated Nutrient Sensing | The distribution of energy from carbohydrate and fat has been observed to promote differential plasma lipid responses in previous weight loss studies, and insulin resistance status may interact with diet composition and affect weight loss and lipid responses. | 26811166 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Since dyslipidaemia is one of the most important risk factors for coronary heart disease (CHD), lowering of LDL-cholesterol (LDL-C) causes significant reduction in morbidity and mortality, particularly in patients with established CHD. | 26812002 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Too many CHD patients with dyslipidaemia are still inadequately treated and most of these patients on statin therapy are not achieving the treatment targets. | 26812002 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | However, PSE was unrelated to prediabetes, insulin resistance, or visceral fat. | 26812049 |
| Fatty degeneration | Deregulated Nutrient Sensing | Prevalence of steatosis was higher among those who had larger waist circumference, insulin resistance, higher HDL cholesterol and a history of antiretroviral therapy. | 26812065 |
| Hepatobiliary Disorder, Fatty degeneration, Hepatitis C | Deregulated Nutrient Sensing | We observed a high burden of liver disease in this relatively young cohort that was primarily driven by chronic HCV infection, metabolic factors (insulin resistance and steatosis) and heavy alcohol use. | 26812065 |
| Prostate Cancer Outcomes Study, Thyroid stimulating hormone measurement | Deregulated Nutrient Sensing | However, we did not find a direct dependency of TSH indicators of insulin resistance neither across the group of women with PCOS, nor with the subgroups. | 26817257 |
| Atherosclerosis | Deregulated Nutrient Sensing | Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been repeatedly reported as an independent positive predictor of cardiovascular mortality. | 26817832 |
| Dyslipidemias, Diabetes Mellitus, Chronic Obstructive Airway Disease, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The prevalence of comorbidities increased in parallel with BMI and included arterial hypertension, diabetes mellitus, dyslipidaemia (all P < 0.001), chronic obstructive pulmonary disease (P = 0.041) and chronic kidney disease (P = 0.056). | 26817848 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Adult participants with dyslipidemia (p < 0.01), prediabetes/diabetes (p = 0.04), and hypertension (p = 0.02) were significantly more likely to obtain lipid monitoring. | 26818535 |
| Cheilitis, Dyslipidemias, Photosensitivity of skin, Xerosis | Deregulated Nutrient Sensing | Several side effects of acitretin have been reported such as teratogenicity, cheilitis, xerosis, dyslipidemia, and photosensitivity. | 26820109 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | During follow-up, he developed hyperglycemia and dyslipidemia, which were controlled by increasing leptin dose and starting oral antidiabetic drugs. | 26821845 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypothyroidism, Lung Diseases, Obstructive | Deregulated Nutrient Sensing | Drugs for cardiovascular diseases, dyslipidemia, diabetes mellitus, hypothyroidism and obstructive pulmonary disease were more frequently purchased than in the sex- and age-adjusted population, with rate ratios ranging from 1.6 to 7.8. | 26821964 |
| Dyslipidemias, Demographics Domain | Deregulated Nutrient Sensing | There was no significant difference between both groups regarding age, presence of DM, and dyslipidemia. | 26828751 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes. | 26829444 |
| Diabetes Mellitus, Non-Insulin-Dependent, Choroidal and Ciliary Body Melanoma pT1d TNM Finding v8 | Deregulated Nutrient Sensing | Insulin resistance reflects the inadequate insulin-mediated use of metabolites and predicts type 2 diabetes (T2D) but is also frequently seen in long-standing type 1 diabetes (T1D) and represents a major cardiovascular risk factor. | 26829444 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We hypothesized that plasma metabolome profiles allow the identification of unique and common early biomarkers of insulin resistance in both diabetes types. | 26829444 |
| Acquired Immunodeficiency Syndrome, HIV Infections, Atherosclerosis | Deregulated Nutrient Sensing | Comparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study). | 26830260 |
| HIV, Coronary Artery Disease | Deregulated Nutrient Sensing | The relation between insulin resistance (IR) and coronary artery disease in patients with human immunodeficiency virus (HIV) infection remains incompletely defined. | 26830260 |
| Thrombolysis, function, Cerebrovascular accident | Deregulated Nutrient Sensing | Higher Insulin Resistance Level is Associated with Worse Clinical Response in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis. | 26830777 |
| Atherosclerosis, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance is linked to atherosclerotic cardiovascular diseases and stroke. | 26830777 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Among 823 obese patients, 353 (42.9%) met the dyslipidemia criteria: 21.7% had hypertriglyceridemia, 19.7% had low levels of HDL-C, 18.6% had hypercholesterolemia, and 13.7% had high levels of LDL-C. | 26831558 |
| Dyslipidemias | Deregulated Nutrient Sensing | Older age and/or high body mass index (BMI) were related to increased prevalence of dyslipidemia. | 26831558 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with both dyslipidemia and grade 2-3 hepatosteatosis had higher levels of ALT, AST and TSH and lower levels of fT4. | 26831558 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia is high in obese children, and hypertriglyceridemia is in the foreground. | 26831558 |
| Dyslipidemias, Liver Dysfunction | Deregulated Nutrient Sensing | Higher levels of IR and more apparent abnormal liver function test results are observed in the context of dyslipidemia and hepatosteatosis coexistence. | 26831558 |
| Steatohepatitis, Dyslipidemias | Deregulated Nutrient Sensing | Metabolic and hormonal alterations related with thyroid functions may also be associated with dyslipidemia and hepatosteatosis in obese patients. | 26831558 |
| Malignant Head and Neck Neoplasm | Deregulated Nutrient Sensing | Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. | 26832959 |
| Demographics Domain, Obesity | Deregulated Nutrient Sensing | Further, we found that elevated serum GGT and ALT levels were significantly positively correlated with the prevalence of DM, independent of central obesity, serum lipid and insulin resistance (IR) in both genders. | 26838740 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | To the contrary, respondents with hypercholesterolemia less often knew that dyslipidemia is a CVD risk factor than patients with normal cholesterol levels (24.1% vs 41.1%, p = 0.0108). | 26839239 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans. | 26840628 |
| Endothelial dysfunction, Obesity | Deregulated Nutrient Sensing | The presence of insulin resistance (IR) is determinant for endothelial dysfunction associated with obesity. | 26840628 |
| Endothelial dysfunction, Obesity | Deregulated Nutrient Sensing | Insulin resistance (IR) is determinant for endothelial dysfunction in human obesity. | 26840628 |
| Arteriosclerosis, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | They had arteriosclerosis risk factors, such as current smoking (16.2%), hypertension (61.5%), diabetes mellitus (38.3%) and dyslipidemia (38.8%). | 26841805 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood. | 26843485 |
| Fatty Liver, Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Here we demonstrate that p38d is elevated in livers of obese patients with NAFLD and that mice lacking p38g/d in myeloid cells are resistant to diet-induced fatty liver, hepatic triglyceride accumulation and glucose intolerance. | 26843485 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our findings verified the close correlation of BCAAs and AAAs with insulin resistance and future development of diabetes in Chinese populations and highlighted the predictive value of these markers for future development of diabetes. | 26846565 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Impact of obstructive sleep apnoea on insulin resistance in nonobese and obese children. | 26846822 |
| Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | Obstructive sleep apnoea (OSA) has been inconsistently associated with insulin resistance and adverse metabolic states. | 26846822 |
| Slow shallow breathing, Obesity, Osage language | Deregulated Nutrient Sensing | In children with mild OSA, the presence of obesity increased the odds for insulin resistance, while higher apnoea/hypopnoea index values emerged among obese children who were more insulin-resistant.The exclusive presence of interactions between OSA and obesity in the degree of insulin resistance is coupled with synergistic contributions by sleep fragmentation to insulin resistance in the context of obesity. | 26846822 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A significant correlation was found between PWV and age (r = 0.67, p < 0.001), Framingham risk score (r = 0.61, p < 0.001), waist to hip ratio (r = 0.45, p < 0.001), systolic blood pressure (r = 0.37, p = 0.01), diabetes (r = 0.32, p = 0.001) and dyslipidemia (r = 0.32, p = 0.001). | 26852242 |
| Dyslipidemias, Coronary Arteriosclerosis, Breast Carcinoma | Deregulated Nutrient Sensing | Patients with breast cancer, obese patients, and those with dyslipidaemia and ischaemic heart disease were more likely to have increased HbA1c. | 26853192 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Insulin resistance (IR) is a main pathophysiologic feature in polycystic ovary syndrome (PCOS) patients which is triggered by elevated oxidative stress in these patients. | 26854246 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | This study showed that selenium supplementation in PCOS patients may worsen insulin resistance in them. | 26854246 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Thorough physical and laboratory examination were performed at baseline (also the cross-sectional survey) to identify the risk factors such as hypertension, dyslipidemia, diabetes, as well as newly defined risk factors like elevated homocysteine, high sensitivity C-reactive protein, and urine micro-albumin. | 26854473 |
| Dyslipidemias, Hypertension, CTCAE, Chest Pain, diabetic | Deregulated Nutrient Sensing | Diabetic patients were older (P = .10), had a higher frequency of hypertension (P < .01) and dyslipidemia (P = .03), and had a trend to a longer time from the onset of chest pain to hospital arrival (P = .08). | 26856212 |
| Obesity | Deregulated Nutrient Sensing | Leptin-induced phospho-STAT3 and phospho-AMPK levels were similar to those in B cells from individuals with obesity. | 26857091 |
| Hyperlipidemia, Hypertension, CTCAE, Comorbidity | Deregulated Nutrient Sensing | Nearly all patients (99.2%) suffered from at least one comorbidity, with hypertension (95.8%) and hyperlipidemia/dyslipidemia (78.3%) being the most prevalent. | 26857244 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Similar values were obtained in patients with and without metabolic comorbidities, such as diabetes, obesity and dyslipidemia (sensitivity 85%, specificity 88% and sensitivity 76%, specificity 94%, respectively). | 26857451 |
| Dyslipidemias, Calcification of the aorta | Deregulated Nutrient Sensing | Cardiovascular risk factors (blood pressure, dyslipidemia, cigarette smoking) and radiological data (maximum aneurism diameter, intra-luminal thrombus, aortic wall calcification) increased these changes. | 26858185 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose Complexity Estimates Insulin Resistance in Either Nondiabetic Individuals or in Type 1 Diabetes. | 26859105 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | In long-standing type 1 diabetes, the inverse correlation between glucose entropy and insulin resistance is preserved, as lower glucose entropy is associated with higher BMI. | 26859105 |
| Aneurysm, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Age, sex, smoking, dyslipidemias, or controlled arterial hypertension had no influence on aneurysm progression rate. | 26859744 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | Clinicians should be aware of this rare manifestation, because newly diagnosed acanthosis nigricans should prompt examination for insulin resistance. | 26860419 |
| Ovarian Carcinoma | Deregulated Nutrient Sensing | Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma. | 26862948 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | In contrast, SIRT1 may be oncogenic because its overexpression has been detected in many cancers. | 26862948 |
| OVCAR-3, Ovarian Carcinoma | Deregulated Nutrient Sensing | The aim of the present study was to clarify the expression and the role of SIRT1 in ovarian carcinoma (OvCa). | 26862948 |
| Mucinous, Adenocarcinoma, Clear Cell, Endometrioid tumor, Serous Cystadenocarcinoma | Deregulated Nutrient Sensing | The expression of SIRT1 was higher in endometrioid, mucinous, and clear-cell carcinomas than in the inclusion cysts of normal ovaries, but not in serous carcinoma (P=0.038). | 26862948 |
| Neoplasm Metastasis, OVCAR-3 | Deregulated Nutrient Sensing | The expression of SIRT1 on OvCa did not correlate with age, stage, location of metastasis, or capsular penetration. | 26862948 |
| Neoplasms | Deregulated Nutrient Sensing | However, elevated SIRT1 expression was a significant predictor of shorter survival in univariate (P=0.038) and multivariate (P=0.037) survival analyses, regardless of the tumor stage. | 26862948 |
| OVCAR-3 | Deregulated Nutrient Sensing | Results of the present study suggest a positive role for SIRT1 in the development of OvCa and its potential as a novel therapeutic target. | 26862948 |
| Refractory anemias, ETV3 wt Allele | Deregulated Nutrient Sensing | The serum RA level is inversely associated with the development of MetS independently of adiposity and insulin resistance. | 26863424 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | A key component of MetS is the development of insulin resistance (IR). | 26863426 |
| Dyslipidemias, Chronic disease | Deregulated Nutrient Sensing | Low levels of food security are associated with dyslipidemia and chronic disease in adults, particularly in women. | 26866948 |
| Dyslipidemias, Chronic disease | Deregulated Nutrient Sensing | There is a gap in knowledge about the relationship between food security among youth and dyslipidemia and chronic disease. | 26866948 |
| Dyslipidemias | Deregulated Nutrient Sensing | In this nationally representative sample, low-income adolescents living in households with marginal food security had increased odds of having a pattern consistent with atherogenic dyslipidemia, which represents a cardiometabolic burden above their risk from adiposity alone. | 26866948 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is a hallmark of type 2 diabetes (T2DM), it is often accompanied by defective beta-cell function (BF) and is involved in the pathophysiology of cardiovascular disease (CVD). | 26868433 |
| Dyslipidemias, Retinal Diseases, Depression, CTCAE | Deregulated Nutrient Sensing | DM 1 patients had a mean QoL score of 0.7369, with retinopathy, depression, dyslipidemia and a serious hypoglycemic crisis significantly reducing QoL. | 26873164 |
| Primary malignant neoplasm, Neuropathy, Dyslipidemias, Depression, CTCAE, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with DM type 2 had a mean QoL score of 0.6582, with hypertension, neuropathy, depression, cancer and dyslipidemia significantly reducing QoL. | 26873164 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Multivariate determinants of higher anterior circulation IMR in DM were dyslipidaemia, hypertension, worsening glycaemic control, and higher body mass index; metformin had a protective effect. | 26874336 |
| Inflammation, Cytomegalovirus, Blood Vessel, Impaired cognition | Deregulated Nutrient Sensing | To address the role of CMV, we investigated univariate and multivariate associations between markers of systemic and endothelial inflammation, vascular damage, insulin resistance (IR), neurocognitive decline, and antibodies reactive with CMV. | 26876416 |
| Abnormal renal function, Communicable Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Concurrently, recipients with a low cTAC (< 5.89 ng/mL) were less likely to become obese (21.3% vs 30.2%, P < 0.05) or to develop dyslipidemia (27.5% vs 44.8%, P <0.05), chronic kidney dysfunction (14.6% vs 22.7%, P < 0.05), and moderate to severe infection (24.7% vs 33.1%, P < 0.05) after LT than recipients in the high mean cTAC group. | 26877618 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Resistin is an adipocyte- and monocyte-derived cytokine that represents a link between obesity, insulin resistance, and type 2 diabetes. | 26882819 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The effect of hypolipidemic treatment on monocyte cytokine release in different age groups of patients with type 2 diabetes and atherogenic dyslipidemia. | 26884290 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study retrospectively analysed the results of 65 patients with type 2 diabetes and atherogenic dyslipidaemia, complying with lifestyle intervention, and receiving metformin. | 26884290 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Furthermore, we found that high body mass index (p < 0.01) and fat mass (p < 0.01) and low adiponectin (p < 0.05) levels have roles in the development of insulin resistance in the prediabetic group. | 26884292 |
| Obesity | Deregulated Nutrient Sensing | We suggested that in the prediabetic period not only obesity but also decreased adiponectin levels play some role in the pathogenesis of insulin resistance. | 26884292 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hypertension and dyslipidemia correlated with lipid oxidation in children with CKD. | 26885251 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The most prevalent risk factors were dyslipidemia (70.9%), and central obesity (39.8%), followed by excess weight (29.6%), and high blood pressure (12.8%). | 26886094 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Excess weight, central obesity, and dyslipidemia were common risk factors in the clustering patterns that showed higher-than-expected prevalence. | 26886094 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Clustering of risk factors (>= two factors) among the adolescents showed considerable prevalence, and there was a non-casual coexistence of excess weight, central obesity, and dyslipidemia (mainly low HDL-cholesterol). | 26886094 |
| Cerebrovascular Disorders, Electrocardiogram: myocardial infarction (finding), Cerebrovascular accident | Deregulated Nutrient Sensing | The identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients with cerebrovascular disease. | 26886418 |
| Electrocardiogram: myocardial infarction (finding), Diabetes Mellitus, Cerebrovascular accident, Tacca leontopetaloides, Ischemic stroke | Deregulated Nutrient Sensing | In this trial involving patients without diabetes who had insulin resistance along with a recent history of ischemic stroke or TIA, the risk of stroke or myocardial infarction was lower among patients who received pioglitazone than among those who received placebo. | 26886418 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Doppler and conventional US were performed in 49 healthy volunteers, without risk factors for nonalcoholic fatty liver disease (NAFLD), and in 49 patients with NAFLD and at least one risk factor: obesity, dyslipidemia and/or diabetes mellitus. | 26887796 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We investigated the association of electrocardiographic (ECG) abnormalities with markers of insulin resistance and pancreatic beta-cell dysfunction in a cross-sectional study of type 2 diabetes patients. | 26889668 |
| diabetic, Ventricular hypertrophy | Deregulated Nutrient Sensing | In type 2 diabetic patients, both oral glucose tolerance testing-derived and HOMA-derived measures of insulin resistance were associated with pathologic Q-waves and left ventricular hypertrophy on ECGs. | 26889668 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Two patients had diabetes and 10 had dyslipidemia. | 26891003 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Visceral Fat Accumulation, Insulin Resistance, and Elevated Depressive Symptoms in Middle-Aged Japanese Men. | 26891344 |
| Bipolar Disorder | Deregulated Nutrient Sensing | To investigate visceral fat accumulation and markers of insulin resistance in relation to elevated depressive symptoms (EDS). | 26891344 |
| Cancer-related fatigue, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is one ofthe CRF associated with numbers of cardiovascular diseases. | 26891515 |
| Aggressive course | Deregulated Nutrient Sensing | We found that BCOb present increased fasting blood glucose, insulin, resistin and monocyte chemoattractant protein 1, insulin resistance and more aggressive tumours. | 26892376 |
| glucose metabolism, Breast Carcinoma | Deregulated Nutrient Sensing | Altogether, our results suggest that glucose dysmetabolism, insulin resistance and changes in adipokine secretion, in particular resistin, may be involved in the development and progression of breast cancer in overweight/obese pre- and postmenopausal women. | 26892376 |
| Myocardial Reperfusion, Chest Pain | Deregulated Nutrient Sensing | Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects. | 26892461 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We hypothesized that insulin resistance could play a role in this population even without diagnosed diabetes. | 26892461 |
| Myocardial Reperfusion, Endothelial dysfunction, Chest Pain | Deregulated Nutrient Sensing | Insulin resistance measured by HOMA-IR is associated with endothelial dysfunction and confers independent prognostic information in non-diabetic patients with chest pain without myocardial perfusion defects. | 26892461 |
| Heart failure, diabetic | Deregulated Nutrient Sensing | The impact of an inverse correlation between plasma B-type natriuretic peptide levels and insulin resistance on the diabetic condition in patients with heart failure. | 26892514 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | HF and diabetes tend to worsen with each other; however, the appearance of an association between them was likely blunted due to the considerable effect of NP in counteracting insulin resistance, even during the metabolically harmful condition of HF. | 26892514 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This study advances understanding from cross-sectional studies and investigation of incident insulin resistance, demonstrating higher level of HGF is associated with incident diabetes and may reflect a unique type of impaired metabolism. | 26892517 |
| Inflammation | Deregulated Nutrient Sensing | In this study, we aim to determine the interactive impact on VLDL profiles from insulin resistance, impairment in liver synthetic function and inflammation. | 26892520 |
| Dyslipidemias | Deregulated Nutrient Sensing | Living in a less affluent neighborhood contributes to higher mortality among dyslipidemia patients. | 26895648 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and T2D are associated with insulin resistance and endogenous hyperinsulinemia and are more common in Black women. | 26896340 |
| Increased insulin level, Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | We hypothesize that insulin resistance and endogenous hyperinsulinemia in Black women with breast cancer contribute to their greater breast cancer mortality and are associated with increased insulin receptor signalling in tumours. | 26896340 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | It may provide the basis for targeting systemic insulin resistance and/or tumour insulin receptor signalling to reduce racial disparities in breast cancer mortality. | 26896340 |
| Inflammation, Fibrosis Assessment | Deregulated Nutrient Sensing | Regarding the stage of fibrosis, patients with advanced fibrosis were older and had more insulin resistance and more inflammation compared with patients that had mild fibrosis. | 26896689 |
| palladium | Deregulated Nutrient Sensing | Decreased insulin resistance and suspected enhanced glucose stimulated insulin secretion decreasing PP2 seem to contribute improved glucose homeostasis after PD. | 26899541 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Calcar Sirt1 expression was significantly reduced, while sclerostin was markedly increased in OP compared to OA patients. | 26902093 |
| Fracture, Osteoporotic Fractures | Deregulated Nutrient Sensing | Reduced femoral neck Sirt1 may play a role in osteoporotic hip fractures in part via influencing local sclerostin expression. | 26902093 |
| Osteoporosis | Deregulated Nutrient Sensing | The therapeutic potential of Sirt1 activation in osteoporosis warrants further investigation. | 26902093 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea. | 26904688 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These findings, from the first human study to investigate an association of PPI or H1RA/H2RA use with NAFLD, suggest that H2RA use may be associated with a lower prevalence of NAFLD, primarily among men with insulin resistance. | 26905606 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or >=two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. | 26907312 |
| Dyslipidemias, Dysglycemia, Obesity | Deregulated Nutrient Sensing | Metabolic dysregulation underlies key metabolic risk factors--obesity, dyslipidemia, and dysglycemia. | 26908103 |
| Cardiovascular Diseases, Dyslipidemias, Dysglycemia, Diabetes Mellitus, Obesity | Deregulated Nutrient Sensing | Cross-sectional samples with or without obesity, dysglycemia, and dyslipidemia, excluding prevalent cardiovascular disease and diabetes or dyslipidemia treatment. | 26908103 |
| Dyslipidemias, Dysglycemia, Obesity | Deregulated Nutrient Sensing | Cross-sectional associations with obesity, dyslipidemia, and dysglycemia were tested in discovery, with external replication of 37 metabolites. | 26908103 |
| Dyslipidemias, Dysglycemia, Obesity | Deregulated Nutrient Sensing | Cross-sectional metabolite associations were identified with obesity (n = 26), dyslipidemia (n = 21), and dysglycemia (n = 11) in discovery. | 26908103 |
| Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Previous research has suggested that activation of the renin-angiotensin-aldosterone system may promote insulin resistance and b-cell dysfunction, but the association with incident diabetes in African Americans is unknown. | 26908112 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We examined the association of aldosterone and renin with insulin resistance, b-cell function, and incident diabetes in a large African American cohort. | 26908112 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Activation of the renin-angiotensin-aldosterone system may play a significant role in the development of insulin resistance and diabetes in African Americans. | 26908112 |
| Glucose Intolerance (disease), Hypoxia | Deregulated Nutrient Sensing | Glucose intolerance associated with hypoxia in people living at high altitudes in the Tibetan highland. | 26908520 |
| Glucose Intolerance (disease), Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | To clarify the association between glucose intolerance and high altitudes (2900-4800 m) in a hypoxic environment in Tibetan highlanders and to verify the hypothesis that high altitude dwelling increases vulnerability to diabetes mellitus (DM) accelerated by lifestyle change or ageing. | 26908520 |
| Glucose Intolerance (disease), Polycythemia, Hypoxemia | Deregulated Nutrient Sensing | After adjusting for lifestyle change, hypoxaemia and polycythaemia were closely associated with glucose intolerance. | 26908520 |
| Glucose Intolerance (disease), Hypoxemia | Deregulated Nutrient Sensing | Socioeconomic factors, hypoxaemia and the effects of altitudes >3500 m play a major role in the high prevalence of glucose intolerance in highlanders. | 26908520 |
| Glucose Intolerance (disease), Polycythemia | Deregulated Nutrient Sensing | Tibetan highlanders may be vulnerable to glucose intolerance, with polycythaemia as a sign of poor hypoxic adaptation, accelerated by lifestyle change and ageing. | 26908520 |
| Weight Gain, Metabolic Diseases | Deregulated Nutrient Sensing | Western dietary pattern predisposes to weight gain, insulin resistance and cardiometabolic diseases. | 26910624 |
| Prediabetes syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Some obese children do not show cardiometabolic complications such as prediabetes, dyslipidemia or insulin resistance. | 26910741 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Our results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway. | 26912037 |
| Units Of Measure - Siemens, Obesity | Deregulated Nutrient Sensing | Participants were classified as MHO or of metabolically unhealthy obesity based on insulin resistance (IR) or cardiometabolic risk (CR) factors (blood pressure, lipids, and glucose). | 26913634 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Significant differences were found between the groups in regard to glycosylated hemoglobin, low density lipoprotein, systolic blood pressure, dyslipidemia, chronic renal failure, and disease duration. | 26914484 |
| Obesity | Deregulated Nutrient Sensing | Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear. | 26916476 |
| Obesity | Deregulated Nutrient Sensing | The sphingolipid metabolism gene pathway was upregulated in muscle in insulin resistance independent of obesity. | 26916476 |
| Hepatitis A, Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, hepatotoxin, Obesity, Arthritis, Psoriatic | Deregulated Nutrient Sensing | Among these, 393 patients with relevant laboratory data were analysed for liver enzymes and their relation to the known risk factors for liver disease (obesity, diabetes mellitus, alcohol consumption, hepatotoxic medications, dyslipidemia, psoriatic arthritis and infectious hepatitis). | 26916498 |
| Carotid Intima-Media Thickness, Dyslipidemias, Endothelial dysfunction, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia, carotid intima-media thickness and endothelial dysfunction in children with chronic kidney disease. | 26921213 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Information on the association of these parameters with dyslipidemia in pre-dialysis pediatric CKD is limited. | 26921213 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | On multivariate analysis, hypertension (OR 3.68, P = 0.044) and male gender (OR 10.21, P = 0.004) were associated with dyslipidemia; cIMT was significantly associated with LDL cholesterol (b = 28.36, P = 0.033). | 26921213 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia was prevalent and cIMT significantly elevated in pre-dialysis pediatric CKD, indicating increased cardiovascular risk. | 26921213 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Elevated LDL cholesterol predicted increased cIMT, strengthening the association between dyslipidemia and atherosclerosis in early CKD. | 26921213 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | For males and females, dyslipidemia and hypertension were not associated with psychological distress after adjusting for other factors. | 26921653 |
| Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is common in type 2 diabetes (T2DM) and predicts cardiovascular disease, but information on the association of its components with atherosclerosis is scarce. | 26921744 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We assessed 96 T2DM patients (median age 63 years, 44% women, 19% smokers, 54% hypertension, 38% dyslipidemia) and 90 non-diabetic controls matched for age, sex, and cardiovascular risk factors. | 26921744 |
| Hyperglycemia, Dyslipidemias, Malignant Neoplasms | Deregulated Nutrient Sensing | Lifestyle-related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. | 26923095 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear. | 26923398 |
| Obesity, Dyslipidemias, ETV3 wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Baseline characteristics associated with an increased risk of incident MCI were MetS (hazard ratio [HR], 1.46; 95% CI, 1.02-2.09), central obesity (HR, 1.41; 95% CI, 1.01-1.98), diabetes mellitus (HR, 2.84; 95% CI, 1.92-4.19), dyslipidemia (HR, 1.48; 95% CI, 1.01-2.15), and 3 or more component cardiovascular risk factors (HR, 1.58; 95% CI, 1.13-2.33). | 26926205 |
| physiopathological, diabetic | Deregulated Nutrient Sensing | Under diabetic conditions, inadequate autophagy promotes cellular dysfunction and insulin resistance in non-vascular tissue. | 26926601 |
| ACSM3 gene, Dyslipidemias, Cerebrovascular accident, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | The major risk factors for stroke are obesity, diabetes mellitus, systemic arterial hypertension (SAH) and dyslipidemia. | 26927647 |
| Dyslipidemias, Tobacco Dependence | Deregulated Nutrient Sensing | Brief report of virtual clinician research tools for tobacco dependence or dyslipidemia. | 26929166 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | We found significantly higher levels in patients with insulin resistance compared to those without (6.4 +- 3.7 vs. 4.1 +- 2.4 ng/ml, r = 0.025) and only a tendency toward higher levels in prediabetes compared to normoglycemic patients (5.9 +- 3.6 vs. 5.3 +- 3.4 ng/ml). | 26934129 |
| Burn injury | Deregulated Nutrient Sensing | We sought to characterize metabolic alterations and insulin resistance after burn injury and determine their magnitude and persistence at discharge. | 26934145 |
| Hyperglycemia | Deregulated Nutrient Sensing | As hyperglycemia and insulin resistance are associated with poor outcomes, studies should focus on how long these profound alterations persist. | 26934145 |
| Burn Specimen Source Codes, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Our findings demonstrated that two-thirds of burn patients had some degree of glucose intolerance. | 26934145 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | However, we cannot exclude the possibility that a higher PWV in pSS patients is caused, not by pSS itself, but by the use of steroids, hypertension and dyslipidemia. | 26935363 |
| Electrocardiogram: myocardial infarction (finding) | Deregulated Nutrient Sensing | Functionally relevant mutations in the dyslipidemia-related genes and enzymes involved in the reverse cholesterol transport system are associated with CAD and contribute to increased susceptibility of myocardial infarction (MI). | 26936456 |
| Fibromyalgia, Impaired | Deregulated Nutrient Sensing | Torque and muscle activation impairment along with insulin resistance are associated with falls in women with fibromyalgia. | 26937773 |
| Intervertebral Disc Degeneration | Deregulated Nutrient Sensing | SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway. | 26940203 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Nitrates users had more frequently diabetes, dyslipidemia, and higher body mass index but were less frequently treated with statins. | 26940569 |
| Osage language | Deregulated Nutrient Sensing | Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA ( P < .001). | 26941371 |
| Sleep Apnea, Obstructive, Dyslipidemias, Osage language | Deregulated Nutrient Sensing | Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. | 26941371 |
| melanoma | Deregulated Nutrient Sensing | We have found that pharmacologic stimulation of the Kv11.3 channel with a small molecule activator, NS1643 induced autophagy via activation of an AMPK-dependent signaling pathway in melanoma cell line. | 26942884 |
| Behavior, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Chronic kidney disease (CKD) is associated with aging, diabetes, hypertension, dyslipidemia, obesity, and unhealthy lifestyle behaviors and has become a public health burden worldwide. | 26943182 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Association Between Insulin Resistance and Luminal B Subtype Breast Cancer in Postmenopausal Women. | 26945364 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Currently, there is limited information on the clinical characteristics of breast cancer patients with insulin resistance. | 26945364 |
| Breast Carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Hence, the purpose of this study was to investigate the association between insulin resistance and clinicopathological factors in newly diagnosed breast cancer patients without diabetes. | 26945364 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Age, menopausal status, body mass index, tumor size, histologic grade, Ki-67 expression, and breast cancer subtype significantly differed according to the presence of insulin resistance. | 26945364 |
| Obesity | Deregulated Nutrient Sensing | Multivariate analysis revealed that postmenopausal status and obesity were significantly associated with insulin resistance. | 26945364 |
| Neoplasms, Obesity | Deregulated Nutrient Sensing | In postmenopausal women, older age, obesity, larger tumor size, advanced stage, and high proliferative luminal B subtype were significantly associated with insulin resistance. | 26945364 |
| Obesity | Deregulated Nutrient Sensing | In contrast, in premenopausal patients, only obesity was related to insulin resistance. | 26945364 |
| Neoplasms, Obesity | Deregulated Nutrient Sensing | Multivariate analysis indicated that insulin resistance was independently correlated with obesity, larger tumor size, and the luminal B/human epidermal growth factor receptor-2-negative subtype in postmenopausal but not premenopausal patients. | 26945364 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Insulin resistance was significantly associated with larger tumors and proliferative luminal B subtype breast cancer in postmenopausal women only. | 26945364 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | These findings suggest that insulin resistance could mechanistically induce tumor progression and might be a good prognostic factor, and that it could represent a therapeutic target in postmenopausal patients with breast cancer. | 26945364 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | This study suggested that obesity may be causally associated with PAD after controlling for the potential intermediate factors like hypertension, dyslipidemia and hyperglycemia. | 26945778 |
| Delirium | Deregulated Nutrient Sensing | Altogether, these results suggest that delirium rats induced by scopolamine may be correlated with an increased cerebral concentration of 5-HT and dopamine neurotransmitters system; the selective 5-HT(1A) antagoniszts can reverse the delirium symptoms at some extent through tendering PI3K/Akt/mammalian target of rapamycin complex 1 (mTOR) activation-induced NLRP3 activity and then reducing IL-1b release. | 26946964 |
| Renal Insufficiency, Hypertension, CTCAE, Metabolic Syndrome X | Deregulated Nutrient Sensing | Increased serum uric acid levels are associated with the presence of cardiovascular risk factors such as hypertension, renal dysfunction, insulin resistance, and metabolic syndrome. | 26947600 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia prevalence were as follows: increased TC 7.8%, increased LDL 6.1%, increased TG 0-9years 22.1%, increased TG 10-16years 11.7%, and decreased HDL 8.0%. | 26948098 |
| Acromegaly | Deregulated Nutrient Sensing | Low insulin resistance after surgery predicts poor GH suppression one year after complete resection for acromegaly: a retrospective study. | 26949262 |
| Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | To the best of our knowledge, this study is the first to compare dual inhibition of PI3K/mammalian target of rapamycin (mTOR) by apitolisib (GDC-0980) against single inhibition of mTORC1 by everolimus in metastatic renal cell carcinoma (mRCC). | 26951309 |
| Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. | 26952538 |
| osteoclast activating factor | Deregulated Nutrient Sensing | The expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF. | 26952538 |
| osteoclast activating factor | Deregulated Nutrient Sensing | So far, information is lacking about the relationship between SIRT1 regulating micro RNAs (miRs), SIRT1 protein and the occurrence of POAF. | 26952538 |
| osteoclast activating factor | Deregulated Nutrient Sensing | Altered expression of the SIRT1 protein regulating miR-199a in human atrial tissue was found to be related to the occurrence of POAF, indicating its usefulness as a biomarker for cardiac surgery management. | 26952538 |
| vascular inflammations, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. | 26954484 |
| vascular inflammations, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study tested the hypothesis that AGE may improve endothelial function, oxidative stress, vascular inflammation and insulin resistance in high risk cardiovascular subjects with type 2 diabetes. | 26954484 |
| vascular inflammations, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In this group of type 2 diabetic patients at high cardiovascular risk, 4 weeks treatment with AGE did not significantly improve endothelial function, vascular inflammation, oxidative stress or insulin resistance. | 26954484 |
| Neuropathy, Dyslipidemias, Diabetes Mellitus, Kidney Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | The factors associated with developing these complications were increasing age, duration of diabetes, hypertension and dyslipidaemia for nephropathy and neuropathy. | 26958014 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | However, elderly Chinese with diabetes would have lower cognition function, and the dyslipidemia might be reversely associated with the cognitive function. | 26959108 |
| diabetic | Deregulated Nutrient Sensing | Insulin Resistance is Associated With Total Bile Acid Level in Type 2 Diabetic and Nondiabetic Population: A Cross-Sectional Study. | 26962776 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The increase in the bile acid level in insulin-resistant population regardless of status of diabetes and glucose level indicated the important role of insulin resistance in the regulation of bile acid metabolism in human. | 26962776 |
| Hepatitis C, Chronic | Deregulated Nutrient Sensing | GC Gene Polymorphism and Unbound Serum Retinol-Binding Protein 4 Are Related to the Risk of Insulin Resistance in Patients With Chronic Hepatitis C: A Prospective Cross-Sectional Study. | 26962819 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C, Chronic liver disease | Deregulated Nutrient Sensing | Insulin resistance (IR) is found in chronic hepatitis C (CHC) more frequently than in other chronic liver diseases.Prospective cross-sectional study to evaluate a wide multitest panel to identify factors related with IR in CHC and their possible interactions.In 76 patients with CHC we performed a series of routine laboratory analysis as well as specifically designed serum biochemical tests [retinol, retinol-binding protein 4 (RBP4), 25-OH vitamin D, Vitamin E, lipopolysaccharide-binding protein (LBP), interleukin-6 (IL-6), and cystatin C]. | 26962819 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with G(120-0) >= 2.50 mmol/L or G30 >= 9.75 mmol/L demonstrated lower degrees of insulin secretion, higher degrees of insulin resistance, and ~6-fold higher risk of developing future diabetes compared to their lower counterparts after adjustment for possible confounding factors. | 26962830 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Body Mass Index Is Better than Other Anthropometric Indices for Identifying Dyslipidemia in Chinese Children with Obesity. | 26963377 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | BMI had better practical utility in identifying dyslipidemia among school-aged children with obesity compared with other anthropometric measures. | 26963377 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | A cross-sectional study was conducted on 288 patients with dyslipidemia, diabetes, or coronary artery disease on statin therapy. | 26964726 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Treatment with PDE5i in humans and murine models of diabetes improves VAT, targeting SIRT1 through a modulation of miR-22-3p expression. | 26964730 |
| Dyslipidemias, Data types - Address, Diabetes Mellitus, Cerebrovascular Disorders, Hypertension, CTCAE | Deregulated Nutrient Sensing | Compared to patients with AD, Dmix patients were older and more likely to present diabetes, hypertension, dyslipidaemia, and history of cerebrovascular disease (P<.05). | 26971058 |
| Glucose Intolerance (disease), Fatty Liver Disease | Deregulated Nutrient Sensing | Fatty liver disease is associated with glucose intolerance and hepatic insulin resistance. | 26971094 |
| Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease, Fatty Liver Disease | Deregulated Nutrient Sensing | However, there are distinct etiologies for alcoholic versus non-alcoholic fatty liver disease (NAFLD), and it is unknown whether alcohol consumption influences the onset of glucose intolerance in fatty liver disease patients. | 26971094 |
| Hypertrichosis, Autosomal recessive inheritance | Deregulated Nutrient Sensing | Donohue syndrome (DS) is a rare and lethal autosomal recessive disease caused by mutations in the insulin receptor (INSR) gene, manifesting marked insulin resistance, severe growth retardation, hypertrichosis, and characteristic dysmorphic features. | 26974131 |
| Neoplasm Metastasis, Colorectal Carcinoma | Deregulated Nutrient Sensing | SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. | 26975631 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | In this study, we explored potential effects of silent mating type information regulation 2 homolog 1 (SIRT1) on CRC metastasis. | 26975631 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Our data showed that ectopic expression of SIRT1 markedly increased the migration and invasion of CRC cells. | 26975631 |
| Aggressive course | Deregulated Nutrient Sensing | In contrast, silencing SIRT1 repressed this behavior in aggressive CRC cells. | 26975631 |
| Neoplasms | Deregulated Nutrient Sensing | Tumor xenograft experiments revealed that knockdown of SIRT1 impaired CRC metastasis in vivo. | 26975631 |
| methionine, Colorectal Carcinoma | Deregulated Nutrient Sensing | Silencing SIRT1 in CRC cells induced mesenchymal-epithelial transition (MET), which is the reverse process of epithelial-mesenchymal transition (EMT) and characterized by a gain of epithelial and loss of mesenchymal markers. | 26975631 |
| Neoplasm Metastasis, Colorectal Carcinoma | Deregulated Nutrient Sensing | Moreover, SIRT1 expression correlated positively with Fra-1 expression, metastasis and overall survival in patients with CRC. | 26975631 |
| Neoplasm Metastasis, Colorectal Carcinoma | Deregulated Nutrient Sensing | Taken together, our data provide a novel mechanistic role of SIRT1 in CRC metastasis, suggesting that SIRT1 may serve as a potential therapeutic target for metastatic CRC. | 26975631 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hyperuricemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Increasing age (OR = 1.012; 95% CI:1.010, 1.014), male sex (OR = 1.411; 95% CI:1.318, 1.510), obesity (OR = 1.424; 95% CI:1.345, 1.507), cardiovascular disease (OR = 1.343; 95% CI:1.125, 1.603), diabetes (OR = 1.955; 95% CI:1.751, 2.182), hypertension (OR = 1.481; 95% CI:1.391, 1.577) and hyperuricemia (OR = 2.223; 95% CI:2.060, 2.399) were independent risk factors of dyslipidemia. | 26978581 |
| Dyslipidemias, CDISC SDTM Lesion Complexity Terminology | Deregulated Nutrient Sensing | Influence of pharmacotherapy complexity on compliance with the therapeutic objectives for HIV+ patients on antiretroviral treatment concomitant with therapy for dyslipidemia. | 26980167 |
| Dyslipidemias, CDISC SDTM Lesion Complexity Terminology | Deregulated Nutrient Sensing | Pharmacotherapeutical complexity represents a key factor in terms of achieving health objectives in HIV+ patients on treatment for dyslipidemia. | 26980167 |
| Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Several compounds in the choline oxidation pathway are associated with insulin resistance and prevalent diabetes; however, prospective data are scarce.We explored the relationships between systemic and urinary choline-related metabolites and incident type 2 diabetes in an observational prospective study among Norwegian patients. | 26980210 |
| Dyslipidemias, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | The magnitude of the healthcare problem of type-2-diabetes increases according to its association with several risk factors for cardiovascular diseases such as obesity and dyslipidemia. | 26982659 |
| Dyslipidemias, Smoking, Diabetes Mellitus, Coronary Artery Disease, Hypertension, CTCAE | Deregulated Nutrient Sensing | Smoking, diabetes mellitus, hypertension, and dyslipidemia are labelled as conventional risk factors for coronary artery disease. | 26982666 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension (65%), smoking (57.8%) and dyslipidemia (45.5%) were the most common risk factors. | 26982666 |
| Metabolic Diseases | Deregulated Nutrient Sensing | This study reports an independent inverse relationship between daily chocolate consumption and levels of insulin, HOMA-IR and liver enzymes in adults, suggesting that chocolate consumption may improve liver enzymes and protect against insulin resistance, a well-established risk factor for cardiometabolic disorders. | 26983749 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Further observational prospective research and well-designed randomised-controlled studies are needed to confirm this cross-sectional relationship and to comprehend the role and mechanisms that different types of chocolate may play in insulin resistance and cardiometabolic disorders. | 26983749 |
| Dyslipidemias | Deregulated Nutrient Sensing | Anti-Retroviral Therapy Increases the Prevalence of Dyslipidemia in South African HIV-Infected Patients. | 26986065 |
| Dyslipidemias | Deregulated Nutrient Sensing | Data on the prevalence of dyslipidaemia and associated risk factors in HIV-infected patients from sub-Saharan Africa is sparse. | 26986065 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Severe dyslipidaemia, (LDLC> 4.9 mmol/L or TG >5.0 mmol/L) was present in <5% of participants. | 26986065 |
| Neoplasms | Deregulated Nutrient Sensing | Several members of the sirtuin family (SIRT1-7), which are a highly conserved family of NAD+-dependent enzymes, play an important role in tumor formation. | 26986234 |
| Lipodystrophy, Complication Aspects | Deregulated Nutrient Sensing | Insulin resistance and metabolic complications are less common than with other lipodystrophy subtypes. | 26987365 |
| Complication Aspects | Deregulated Nutrient Sensing | She presented no severe metabolic complications, neither signs of insulin resistance. | 26987365 |
| acetate-CoA ligase activity, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The area under the receiver-operating characteristic curve for prediction of positive CACS increased from 0.665 when considering only risk factors (dyslipidemia, current smoking, hypertension, diabetes, and age) to 0.719 when adding femoral and carotid plaques (p < 0.001). | 26988945 |
| Metabolic Diseases, Dental Plaque, Data types - Address | Deregulated Nutrient Sensing | The neuritic plaque pathology of AD was associated with metabolic disorders such as insulin resistance and abnormal lipid metabolism, whereas the risk factors for tau pathology remain unclear. | 26989005 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Increased stages of fibrosis were primarily associated with higher levels of HOMA2-insulin resistance (IR), procollagen type I propeptide (P1NP), lower osteocalcin, albumin-corrected calcium, parathyroid hormone, vitamin D, male sex, and higher age. | 26989059 |
| Dyslipidemias, Albuminuria | Deregulated Nutrient Sensing | Individuals with higher HbA1c levels were more likely to have albuminuria (OR 3.14, 95% CI 1.26-7.82) and dyslipidaemia (OR 2.37, 95% CI 1.29-4.34) and visited the clinic more often (OR 2.52, 95% CI 1.26-4.99). | 26989697 |
| Cholesterol to HDL-Cholesterol Ratio Measurement | Deregulated Nutrient Sensing | Polyphenols from olive oil and thyme modified the lipoprotein subclasses profile and decreased the total LDL particle/total HDL particle (HDL-P), small HDL/large HDL, and HDL-cholesterol/HDL-P ratios, and decreased the lipoprotein insulin resistance index (LP-IR) (p < 0.05). | 26992050 |
| Pancreatitis | Deregulated Nutrient Sensing | Insulin Resistance as a Novel Risk Factor for Post-ERCP Pancreatitis: A Pilot Study. | 26995780 |
| Pancreatitis | Deregulated Nutrient Sensing | The relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known. | 26995780 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Obese PCOS patients have a higher risk of elevated insulin resistance and b-cell function than do those with BMI <30. | 26995881 |
| Hypoxia | Deregulated Nutrient Sensing | Furthermore, leptin counteracted the downmodulation of SIRT1 induced by hypoxia, and persistent high levels of SIRT1 were directly involved in HIF-1a stabilization. | 26996298 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Leptin signaling axis, including the new proposed intermediate SIRT1, could represent a new diagnostic and therapeutic target in prostate cancer. | 26996298 |
| Obesity, Abdominal, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | We observed that abdominal obesity, family history of diabetes mellitus, and medical history of hypertension and dyslipidemia are independent risk factors for early-onset T2DM. | 26996471 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians. | 26999517 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Previous studies have explored the association of silent mating-type information regulator 2 homolog 1 (SIRT1) gene expression with prognosis in breast cancer. | 26999517 |
| Breast Carcinoma | Deregulated Nutrient Sensing | However, no studies exist, so far, on the role of SIRT1 gene polymorphism in breast cancer risk or prognosis. | 26999517 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Breast cancer patients exhibited elevated serum SIRT1 levels which varied among different tumor grades. | 26999517 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Our findings reveal that rs3758391 and rs12778366 polymorphisms of SIRT1 gene are associated with breast cancer risk and prognosis in the Egyptian population. | 26999517 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | We hypothesized that culinary herbs and spices may decrease insulin resistance (IR) and improve WM in prediabetes. | 27001275 |
| Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | Interestingly, PDK4 regulated AMPK phosphorylation which in turn affected cell viability in CK2 inhibitor treated glioma cells. | 27001465 |
| Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | Taken together, CK2 inhibition in glioma cells drives the PDK4-AMPK axis to affect metabolic profile that has a strong bearing on their survival. | 27001465 |
| Diabetes Mellitus, Non-Insulin-Dependent, Prehypertension | Deregulated Nutrient Sensing | Metabolic markers associated with insulin resistance predict type 2 diabetes in Koreans with normal blood pressure or prehypertension. | 27001495 |
| Increased insulin level, Hypertensive (finding) | Deregulated Nutrient Sensing | The premise of this analysis is that insulin resistance/compensatory hyperinsulinemia is a major predictor of T2DM, and the greater the prevalence of insulin resistance within any population, normotensive or hypertensive, the more likely T2DM will develop. | 27001495 |
| Prehypertension | Deregulated Nutrient Sensing | The hypothesis to be tested is that surrogate estimates of insulin resistance will predict incident T2DM to a significant degree in persons with normal blood pressure or prehypertension. | 27001495 |
| Increased insulin level, Blood Glucose, Dyslipidemias, Prehypertension | Deregulated Nutrient Sensing | Metabolic variables associated with insulin resistance (glycemia, insulinemia, and dyslipidemia) predict the development of T2DM in patients with either normal blood pressure or prehypertension. | 27001495 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies. | 27002938 |
| Neoplasms | Deregulated Nutrient Sensing | OSI-027 inhibits mTORC1/2 in patients with advanced tumour s in a dose-dependent manner but doses above the tolerable levels in S1 and S3 are required for a sustained biological effect in tumour biopsies. | 27002938 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidaemia in Poland continues to be high--over 60% of adults have hypercholesterolaemia, and control remains poor. | 27004543 |
| Dyslipidemias, Myocardial Ischemia, Hepatitis C, Hypertensive (finding), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Twenty six (27%) patients had family history of ischemic heart disease, 51 (53.12%) were smokers, 12 (12.5%) were hypertensive, 4 (4.16%) had type 2 diabetes, 23 (23.9%) had dyslipidemia, and 31 (32.3%) were infected with hepatitis C virus. | 27005326 |
| Hypertension, CTCAE, Heart failure, Dyslipidemias | Deregulated Nutrient Sensing | The patients invited to participate had heart failure and/or hypertension and/or dyslipidemia. | 27007065 |
| Cessation of life, Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Dyslipidemia is the most common factor leading to ischemic heart disease, which is one of the leading causes of death. | 27007528 |
| Chagas Disease, Dyslipidemias | Deregulated Nutrient Sensing | The potential influence of atherogenic dyslipidemia on the severity of chronic Chagas heart disease. | 27008492 |
| Dyslipidemias, Hypertension, CTCAE, Coronary heart disease | Deregulated Nutrient Sensing | Dyslipidemia, arterial hypertension and coronary heart disease were present in the majority of the patients in both groups. | 27015235 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and coronary artery disease had no effect. | 27015580 |
| Glucose Intolerance (disease), Diabetes, Autoimmune | Deregulated Nutrient Sensing | In 2013, she was diagnosed with glucose intolerance and subsequently with latent autoimmune diabetes of adulthood. | 27017730 |
| Hyperprolactinemia, DIAPH2 gene, Prostate Cancer Outcomes Study, Ovarian Failure, Premature, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | There were no significant differences in the prevalence of polycystic ovary syndrome (PCOS), hyperprolactinemia, or premature ovarian failure (POF) between the non-obese women with and without insulin resistance. | 27018331 |
| Inflammation | Deregulated Nutrient Sensing | Serum androgens and inflammation might not contribute to insulin resistance in these women. | 27018331 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. | 27020448 |
| Psoriasis, Chronic inflammatory disorder, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Psoriasis is a chronic inflammatory disease that has been associated with an increased incidence of insulin resistance and diabetes mellitus (DM). | 27023086 |
| Psoriasis | Deregulated Nutrient Sensing | This study confirms a beneficial effect of anti-TNF-a agents on insulin resistance and insulin sensitivity in psoriasis patients with type 2 DM. | 27023086 |
| Ventricular Fibrillation | Deregulated Nutrient Sensing | Women with lower circulating TSH had higher risk of having a VF, independently of age, menopausal age, and insulin resistance. | 27023333 |
| Dilated Cardiomyopathy Pathway, Diabetes Mellitus | Deregulated Nutrient Sensing | Efficacy of CD34+ Stem Cell Therapy in Nonischemic Dilated Cardiomyopathy Is Absent in Patients With Diabetes but Preserved in Patients With Insulin Resistance. | 27025690 |
| Doctor of Chiropractic, Dilated Cardiomyopathy Pathway, Diabetes Mellitus | Deregulated Nutrient Sensing | We evaluated the association of diabetes and insulin resistance with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM). | 27025690 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Twelve patients had diabetes mellitus (DM group), 17 had insulin resistance (IR group), and 16 displayed normal glucose metabolism (no-IR group). | 27025690 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: a randomised controlled clinical trial. | 27028002 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Improvement of insulin resistance and inflammation is a basic strategy in the management of type 2 diabetes. | 27028002 |
| Inflammation | Deregulated Nutrient Sensing | There is limited evidence that prebiotics improve insulin resistance and inflammation. | 27028002 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | However, the ameliorating effect of resistant dextrin, as a prebiotic, on insulin resistance and inflammation in patients with type 2 diabetes has not been investigated so far. | 27028002 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Therefore, the present study aimed to examine the effects of resistant dextrin on insulin resistance and inflammation in type 2 diabetic patients. | 27028002 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In conclusion, resistant dextrin supplementation can modulate inflammation and improve insulin resistance in women with type 2 diabetes. | 27028002 |
| Obesity | Deregulated Nutrient Sensing | None of the patients had obesity and/or insulin resistance. | 27030332 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a known risk factor for cardiovascular disease and is a leading cause of mortality in developed and developing countries. | 27033172 |
| Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | In multivariate logistic regression model, increase of age (for females), abdominal obesity, overweight and obesity, hypertension, and diabetes were associated with an increased odd of dyslipidemia. | 27033172 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemia in middle-aged urban population in Iran is high, and with increasing age there is an increased risk of dyslipidemia. | 27033172 |
| Dyslipidemias, Cardiovascular Diseases, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | DM was also associated with and family history of dyslipidemia in women, cardiovascular disease in men, and with hypertension, dyslipidemia and family history of diabetes in both sexes. | 27035920 |
| Weight decreased, Feeding behaviors, Obesity | Deregulated Nutrient Sensing | Can early weight loss, eating behaviors and socioeconomic factors predict successful weight loss at 12- and 24-months in adolescents with obesity and insulin resistance participating in a randomised controlled trial? | 27036113 |
| Weight decreased, Obesity | Deregulated Nutrient Sensing | This study aimed to identify predictors of weight loss at 12- and 24-months in adolescents with obesity and clinical features of insulin resistance. | 27036113 |
| Proteinuria, Toxic effect, Dyslipidemias, Hypertension, CTCAE, Fatigue | Deregulated Nutrient Sensing | Most frequent toxicities included fatigue, hypertension, dyslipidemia, and proteinuria. | 27036973 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Besides hyperglycaemia and insulin resistance, several factors are associated with a higher cardiovascular risk in type 2 diabetes mellitus (T2DM), many of them being closely related to each other owing to common origins or pathways. | 27037039 |
| AHSG protein, human, Arterial calcification | Deregulated Nutrient Sensing | Fetuin-A is a hepatic secretory protein that both promotes insulin resistance and inhibits arterial calcification. | 27038419 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | For the major risk factors of diabetes, hypertension, and dyslipidemia, management for most patients is on the basis of well developed and extensive evidence-based diagnostic and therapeutic guidelines. | 27040095 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Homeostasis model assessment of b-cell function along with homeostasis model assessment of insulin resistance showed increasing trends as onset age increased in recent-onset diabetes (P for trend < 0.001 in both). | 27042276 |
| diabetic | Deregulated Nutrient Sensing | Elderly-onset diabetic patients had higher insulin resistance and relatively preserved b-cell function compared with middle-age-onset patients. | 27042276 |
| Impaired T cell function, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance, b-cell dysfunction, and ectopic fat deposition have been implicated in the pathogenesis of coronary artery disease (CAD) and type 2 diabetes, which is common in CAD patients. | 27045985 |
| diabetic | Deregulated Nutrient Sensing | We firstly found that the levels of AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor coactivator 1a (PGC1a), silent mating-type information regulation 2 homolog 3 (Sirt3) and manganese superoxide dismutase (MnSOD) were all decreased in the skeletal muscle of diabetic patients. | 27049825 |
| diabetic | Deregulated Nutrient Sensing | Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1a-SIRT3 signaling pathway. | 27049825 |
| diabetic | Deregulated Nutrient Sensing | The findings of our study suggest that the expression of AMPK, PGC1a, Sirt3 and MnSOD are decreased in the skeletal muscle of diabetic patients. | 27049825 |
| Neoplasms | Deregulated Nutrient Sensing | Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor. | 27050276 |
| Osteosarcoma | Deregulated Nutrient Sensing | Cisplatin (CP) activated the IGF-1R/AKT/mTORC1 pathway and stabilized p53 in osteosarcoma (OS) cells. | 27050276 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Together, the results demonstrate 1) p53 expression determines the effect of IGF-1R inhibition on cancer cell CP response, and 2) crosstalk between the IGF-1R/AKT/mTORC1 pathway and p53 and p27 can reduce cancer cell responsiveness to chemotherapy and may ultimately limit the effectiveness of IGF-1R pathway inhibitors in the clinic. | 27050276 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. | 27051864 |
| Inflammation | Deregulated Nutrient Sensing | Our study may provide a novel mechanism for the development of sterile inflammation in adipose tissue and a potential therapeutic target for insulin resistance. | 27051864 |
| diabetic | Deregulated Nutrient Sensing | In conclusion, the findings of the present study indicated that the addition of exogenous 3DG directly contributed to the induction of insulin resistance by impairing insulin signaling in the HepG2 cells, which suggested that 3DG may be involved in worsening of the diabetic condition. | 27052187 |
| Dyslipidemias, Fatty degeneration | Deregulated Nutrient Sensing | Apolipoprotein-B 100 (ApoB-100) is a dyslipidemia marker and steatosis predictor. | 27054361 |
| Dyslipidemias | Deregulated Nutrient Sensing | It is well known that reduced glomerular filtration rate (GFR) leads to an increased risk of dyslipidemia, insulin resistance, and cardiovascular mortality. | 27056725 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are both closely associated with type 2 diabetes mellitus (T2DM). | 27060004 |
| Obesity | Deregulated Nutrient Sensing | It is, however, not clear whether the role of obesity in the development of T2DM is dependent on insulin resistance. | 27060004 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Diabetic patients were more frequently affected by hypertension (p<0.001) and dyslipidemia (p<0.001) and more frequently dialyzed (p=0.010). | 27060269 |
| Dyslipidemias | Deregulated Nutrient Sensing | Besides, in CAE group the proportion of dyslipidemia was higher than normal subject. | 27061992 |
| Chronic Lymphocytic Leukemia, Diabetes Mellitus, Insulin resistance syndrome | Deregulated Nutrient Sensing | We report the case of a patient with diabetes presenting a severe insulin-resistance syndrome due to the production of insulin autoantibodies by a lymphocytic lymphoma. | 27062110 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Observed differences in serum BDNF levels, genetic variants, and DNA methylation patterns across different glucose metabolic state suggest that BDNF may be involved in the pathophysiological process of insulin resistance and type 2 diabetes. | 27062899 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A common PTEN variation is associated with peripheral insulin resistance and subsequent risk of developing T2D. | 27068875 |
| Glucose Intolerance (disease), Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Impaired fasting glucose (IFG) and impaired glucose intolerance (IGT) are predictors of cardiovascular disease (CVD). | 27069111 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | VO2peak and ghrelin levels increased after 8 weeks aerobic exercise; however, plasma leptin and insulin resistance were not affected by this protocol in male patients with colorectal cancer. | 27072232 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Prognostic and clinical value of Sirt1 expression in gastric cancer: A systematic meta-analysis. | 27072976 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Many studies have reported that the expression of silent information regulator 1 (Sirt1) is associated with the clinical features and prognosis of patients with gastric cancer, but the exact function remains controversial. | 27072976 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | We conducted this study to illustrate the clinical and prognostic value of Sirt1 in gastric cancer. | 27072976 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | It was suggested that the high expression of Sirt1 implies a poor prognosis of gastric cancer patients in a relatively short period (3 years), but not in a long time (>=5 years). | 27072976 |
| Neoplasms | Deregulated Nutrient Sensing | The expression of Sirt1 is also linked with patients' age, T stage, N stage and tumor differentiation. | 27072976 |
| Inflammation, diabetic | Deregulated Nutrient Sensing | Insulin Resistance in Relation to Lipids and Inflammation in Type-2 Diabetic Patients and Non-Diabetic People. | 27073920 |
| Inflammation, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | To translate our experimental findings to clinical practice, we investigated in Chinese type-2 diabetic patients and in Flemish non-diabetic people the independent and joint associations of insulin resistance with markers of dyslipidaemia and inflammation, while looking for consistency between ethnicities and across the spectrum of insulin resistance. | 27073920 |
| Negative Regulation of Cell Cycle | Deregulated Nutrient Sensing | High doses of leptin induced cell cycle arrest and senescence in CPCs by activating the p53/p21 pathway and inhibiting the Sirt1 pathway. | 27077804 |
| Degenerative polyarthritis, Degenerative disorder of cartilage | Deregulated Nutrient Sensing | Activating the leptin pathway induced higher Ob-Rb expression and was significantly correlated with cartilage degeneration (lower levels of Coll-2) and tissue senescence (higher levels of p53/p21 and lower levels of Sirt1) in OA patients, suggesting that leptin-induced CPCs senescence contributes to the development of OA. | 27077804 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The Relationship between Dyslipidemia and Acute Axonal Function in Type 2 Diabetes Mellitus In Vivo. | 27078166 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | In addition, affected individuals have non-neuronal symptoms such as diabetes mellitus or glucose intolerance. | 27079523 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Higher exposure to certain phthalates is associated with a diabetes and insulin resistance, with sex differences seen. | 27079661 |
| Alzheimers Disease", Population at Risk | Deregulated Nutrient Sensing | Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults. | 27079723 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. | 27080156 |
| Tacca leontopetaloides, Ischemic stroke | Deregulated Nutrient Sensing | We sought to develop an instrument to screen for insulin resistance in nondiabetic patients with recent ischemic stroke or transient ischemic attack (TIA). | 27080156 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Our 2 scoring systems performed well in identifying stroke patients with insulin resistance, but they are probably not sufficiently accurate for high-stake clinical decisions. | 27080156 |
| physiopathological | Deregulated Nutrient Sensing | Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women. | 27080554 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Particularly, expressions of SIRT1 and SIRT4 were found to be significantly down-regulated in breast cancer tissues and SKBR3 breast cancer cells. | 27080717 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | In conclusion, Sirtuin family of genes shows differential expressions in breast cancer tissues and cells and SIRT1 and SIRT4 seem to play key tumor suppressor roles in breast cancer development. | 27080717 |
| Metastatic hepatocellular carcinoma | Deregulated Nutrient Sensing | SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1a-mediated mitochondrial biogenesis. | 27081083 |
| Neoplasms, Malignant Neoplasms | Deregulated Nutrient Sensing | SIRT1 is a multifaceted NAD+-dependent protein deacetylase known to act as a tumor promoter or suppressor in different cancers. | 27081083 |
| Neoplasm Metastasis, FAM126A gene | Deregulated Nutrient Sensing | Here, we describe a novel mechanism of SIRT1-induced hepatocellular carcinoma (HCC) metastasis. | 27081083 |
| Neoplasm Metastasis, Neoplasms, Vascular Invasion Assessment, FAM126A gene, TNM Staging System | Deregulated Nutrient Sensing | SIRT1 overexpression was frequently detected in human HCC specimens and was associated with microvascular invasion (P = 0.0039), advanced tumor node metastasis (TNM) stages (P = 0.0016), HCC recurrence (P = 0.021) and poor outcomes (P = 0.039). | 27081083 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | Lentivirus-mediated knockdown of SIRT1 in MHCC97H cells reduced invasion and metastasis in vitro and in vivo. | 27081083 |
| FAM126A gene | Deregulated Nutrient Sensing | Elevated SIRT1 expression strongly correlated with the upregulation of PGC-1a in HCC specimens, and ectopic expression of SIRT1 increased PGC-1a levels. | 27081083 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | In cell assays and an orthotopic transplantation model, PGC-1a overexpression reversed the inhibitory effects of SIRT1 depletion on invasion and metastasis by enhancing mitochondrial biogenesis. | 27081083 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | These findings reveal the involvement of SIRT1 in HCC metastasis and provide a rationale for exploring therapeutic targets against the SIRT1/PGC-1a axis. | 27081083 |
| Dyslipoproteinemias, Dyslipidemias | Deregulated Nutrient Sensing | However, the exact associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption remain unknown. | 27082578 |
| Squamous cell carcinoma of esophagus, Dyslipidemias | Deregulated Nutrient Sensing | The findings of this study investigating factors that could predict the outcome of NAC(R)T suggest that the prevalence of dyslipidemia influences the outcome of NAC(R)T for ESCC. | 27082598 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In clinical evaluation, plasma sSortilin was detected at significantly higher levels in cardiovascular risk patients with hypertension, dyslipidemia, and/or diabetes without CAD (non-CAD, 18.7 +- 3.3 ng/mL) than in patients with CAD under aspirin therapy (17.1 +- 3.6 ng/mL; p < 0.01) or in healthy controls (16.8 +- 2.9 ng/mL; p < 0.01). | 27085161 |
| Kidney Failure, Chronic, Dyslipidemias, Hypertension, CTCAE, Congestive heart failure | Deregulated Nutrient Sensing | After adjusting for age, gender, race/ethnicity, presence of dyslipidemia, CHF, and hypertension, CAS performed in ESRD patients was associated with higher rates of in-hospital mortality (OR 3.7, 95% CI 1.0-13.9; P = .04) and moderate to severe disability (OR 1.7, 95% CI 1.0-3.3; P = .05). | 27085817 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Familial dyslipidemia, a frequent genetic cause of premature cardiovascular disease, is still underdiagnosed and undertreated. | 27089599 |
| Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | (cardiovascular diseases), Allium sativum L. (dyslipidemia), Cuminum cyminum L. (hypertension), Macrotyloma uniflorum Verdc. | 27090346 |
| Hyperglycemia, Critical Illness | Deregulated Nutrient Sensing | Effect of vitamin D on stress-induced hyperglycaemia and insulin resistance in critically ill patients. | 27091752 |
| diabetic | Deregulated Nutrient Sensing | Effects of vitamin D supplementation on the glycaemic indices and insulin resistance in diabetic and non-diabetic patients were studied. | 27091752 |
| Hyperglycemia, Critical Illness | Deregulated Nutrient Sensing | In this study, effects of vitamin D supplementation on stress-induced hyperglycaemia and insulin resistance were evaluated in non-diabetic surgical critically ill patients. | 27091752 |
| Sleep Apnea Syndromes | Deregulated Nutrient Sensing | Several studies have reported the association between sleep apnea syndrome and insulin resistance. | 27095251 |
| Sleep Apnea Syndromes, Overweight | Deregulated Nutrient Sensing | Being overweight is known risk factor both for sleep apnea syndrome and insulin resistance. | 27095251 |
| Prediabetes syndrome, diabetic | Deregulated Nutrient Sensing | Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study. | 27095446 |
| diabetic | Deregulated Nutrient Sensing | Additionally, the postprandial response was evaluated according to basal insulin resistance subgroups in patients non-diabetic and diabetic without pharmacological treatment (N = 642). | 27095446 |
| TG gene | Deregulated Nutrient Sensing | Patients with liver insulin resistance (liver-IR) showed higher postprandial response of TG compared with those patients with muscle-IR or without any insulin-resistance respectively (p < 0.001). | 27095446 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent, Insulin Resistance | Deregulated Nutrient Sensing | The postprandial response increases progressively according to non-diabetic, prediabetic and type 2 diabetic state and it is higher in patients with liver insulin-resistance. | 27095446 |
| Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia (48.9% vs. 26.9%), sport lack (46.6% vs. 31.6%), diabetes mellitus (21.3% vs. 16.5%), and atrial fibrillation (18.7% vs. 9.8%) were more prevalent in the urban group, while smoking (26.5% vs. 28.8%), previous stroke (10.1% vs. 16.9%), and transient ischemic attack (20.9% vs. 24.6%) were less prevalent. | 27096105 |
| Retention (Psychology), Chronic Kidney Diseases | Deregulated Nutrient Sensing | The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance. | 27100399 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Whether prebiotics can reduce intestinal generation of these microbial metabolites and improve insulin resistance in CKD patients not yet on dialysis remains unknown. | 27100399 |
| Axos, Retention (Psychology), Chronic Kidney Diseases | Deregulated Nutrient Sensing | In conclusion, we could not demonstrate an influence of prebiotic AXOS on microbiota derived uremic retention solutes and insulin resistance in patients with CKD not yet on dialysis. | 27100399 |
| Obesity | Deregulated Nutrient Sensing | Obesity and Insulin Resistance Screening Tools in American Adolescents: National Health and Nutrition Examination Survey (NHANES) 1999 to 2010. | 27103108 |
| Obesity | Deregulated Nutrient Sensing | To identify which feasible obesity and insulin resistance (IR) screening tools are most strongly associated in adolescents by using a nationally representative sample. | 27103108 |
| Asthma, Obesity | Deregulated Nutrient Sensing | Insulin resistance modifies the association between obesity and current asthma in adults. | 27103388 |
| Asthma, Obesity | Deregulated Nutrient Sensing | The relationship between obesity and current asthma was stronger with increasing insulin resistance tertiles (OR 2.05, 95% CI 2.76-3.00; p-value for interaction 0.03). | 27103388 |
| Asthma | Deregulated Nutrient Sensing | Targeting insulin resistance may represent a novel therapeutic strategy for obese patients with asthma. | 27103388 |
| diabetic | Deregulated Nutrient Sensing | In the intergroup comparison, insulin resistance (p = 0.044) and hemoglobin (p = 0.001) were worse in the group that used LHRH analogs, which was mainly diabetic patients (p = 0.007). | 27103427 |
| Bone Demineralization, Pathologic, Anemia, diabetic | Deregulated Nutrient Sensing | This study showed that LHRH analogs had worse effects relative to insulin resistance, mainly in diabetic patients, and induced more anemia and bone demineralization compared to surgical castration. | 27103427 |
| Dyslipidemias, Congestive heart failure | Deregulated Nutrient Sensing | Compared with patients without SVA, patients with new onset SVA were older (69 +- 12 yrs vs 59 +- 13 yrs, P=.003), had congestive heart failure (47% vs 24%, P=.015) and dyslipidemia (41% vs 15%, P=.002). | 27103771 |
| Dyslipidemias | Deregulated Nutrient Sensing | This suggests that rare mutations in OSBPL genes may contribute to dyslipidemias. | 27105157 |
| Carotid Stenosis, Dyslipidemias | Deregulated Nutrient Sensing | All demographic data were similar between the two groups except for dyslipidemia, which was greater in the BZ group (72% vs 47%, P = .03) and the subocclusive feature of carotid stenosis (14% in the TI group vs 33% in the BZ group, P .04). | 27109793 |
| Rabson-Mendenhall Syndrome | Deregulated Nutrient Sensing | Rabson-Mendenhall syndrome is a rare genetic disorder resulting from mutations in the insulin receptor and is associated with high degrees of insulin resistance. | 27112737 |
| Uterine Polyp, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The incidence of diabetes, hypertension, and dyslipidemia was higher among women with endometrial polyps (P < 0.0001). | 27116465 |
| Uterine Polyp, Hyperglycemia, Dyslipidemias, ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | In postmenopausal women, obesity, dyslipidemia, hyperglycemia, and the presence of MetS were predictive factors for endometrial polyps. | 27116465 |
| Lipolysis, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is secreted from adipocytes in association with catecholamine-induced lipolysis, and elevated serum FABP4 level is associated with obesity, insulin resistance and atherosclerosis. | 27124282 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | While laboratory studies show that air pollutants can potentiate insulin resistance, the epidemiologic evidence regarding the association of air pollution with diabetes incidence is conflicting. | 27124624 |
| Angioimmunoblastic Lymphadenopathy, Malignant Neoplasms | Deregulated Nutrient Sensing | Rrecently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma, but has not yet been explored in Angioimmunoblastic T-cell lymphoma (AITL). | 27124741 |
| Drug Eruptions, Hyperglycemia, Hypertensive (finding), Obesity | Deregulated Nutrient Sensing | We have diagnosed 81 cases of drug-induced hypertension, and 43 patients with hypertensive crises; 72 cases of iatrogenic hyperglycemia; 36 cases of drug-induced hyperuricemia; 50 cases of drug-induced dyslipidemias; and 17 cases of iatrogenic obesity. | 27125072 |
| Calculi | Deregulated Nutrient Sensing | Calculated insulin resistance correlates with stone-forming urinary metabolic changes and greater stone burden in high-risk stone patients. | 27125629 |
| Increased insulin level, Pathogenesis, Hypercalciuria | Deregulated Nutrient Sensing | Proposed mechanisms of lithogenesis include insulin resistance causing low urine pH and hyperinsulinemia leading to hypercalciuria. | 27125629 |
| Pathogenic organism | Deregulated Nutrient Sensing | Herein, we sought to determine whether insulin resistance was associated with differences in stone burden and lithogenic changes on 24-hour urine samples. | 27125629 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | In univariate analysis, dyslipidemia, age, coronary artery disease, antiplatelet agents, number of catheters used, urgent settings, and interventional procedures were significantly different. | 27127790 |
| Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Weight decreased, Hypertension, CTCAE | Deregulated Nutrient Sensing | After adjusting for age, BMI, sex, diabetes, hypertension, and dyslipidemia, patients that developed organ cancer achieved less weight loss (-1.5 % TWL, 95 % CI = [-2.9 %, -0.1 %], p = 0.034). | 27129801 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Prediction of insulin resistance in type 2 diabetes mellitus using routinely available clinical parameters. | 27131406 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Effect of metformin by employing 2-hour postload insulin for measuring insulin resistance in Taiwanese women with polycystic ovary syndrome. | 27131512 |
| Obesity | Deregulated Nutrient Sensing | Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications. | 27133129 |
| Obesity | Deregulated Nutrient Sensing | Chronic Activation of g2 AMPK Induces Obesity and Reduces b Cell Function. | 27133129 |
| Obesity | Deregulated Nutrient Sensing | Here, we observe that mice with chronic AMPK activation, resulting from mutation of the AMPK g2 subunit, exhibit ghrelin signaling-dependent hyperphagia, obesity, and impaired pancreatic islet insulin secretion. | 27133129 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk. | 27134062 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | The precise associations between stroke and carotid plaques and dyslipidemia are unclear. | 27134771 |
| Hypomagnesemia, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypomagnesemia is a frequent finding in kidney transplant patients and plays a causal role in insulin resistance and diabetes. | 27136250 |
| Obesity, Abdominal, Diabetes Mellitus | Deregulated Nutrient Sensing | We conclude that low fitness, adiposopathy, as well as adiposity (and in particular abdominal obesity) are independent contributors to insulin resistance in men without diabetes. | 27139423 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | We included hypertension, dyslipidemia, diabetes, overweight/obesity, smoking, and family history of cardiovascular disease in the count of traditional risk factors (CRFs). | 27139787 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Low birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear. | 27141948 |
| Scleroderma , Infection caused by Helicobacter pylori | Deregulated Nutrient Sensing | Type B insulin resistance syndrome with Scleroderma successfully treated with multiple immune suppressants after eradication of Helicobacter pylori infection: a case report. | 27142369 |
| Autoimmune Diseases | Deregulated Nutrient Sensing | Type B insulin resistance is a rare autoimmune disease characterized by the presence of autoantibodies against the insulin receptor. | 27142369 |
| Autoimmune Diseases | Deregulated Nutrient Sensing | The present case suggests H pylori infection-related pathological mechanism may contribute to type B insulin resistance syndrome and autoimmune disorders. | 27142369 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | They help patients achieve disease-state goals for diabetes, hypertension, and dyslipidemia through a variety of clinical interventions and by promoting medication adherence. | 27143351 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Inhibition of CTRP5 action may result in the alleviation of insulin resistance associated with obesity and diabetes. | 27143553 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Glucose intolerance (insulin resistance) is the main feature of type 2 diabetes. | 27143868 |
| Breast Carcinoma, Neoplasms | Deregulated Nutrient Sensing | mir-101-3p is a key regulator of tumor metabolism in triple negative breast cancer targeting AMPK. | 27145268 |
| Breast Carcinoma, Malignant Neoplasms | Deregulated Nutrient Sensing | Recently, AMPK dysfunction has been highlighted in cancers, including breast cancer. | 27145268 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The aim of this study is to investigate the biological roles of mir-101-3p and AMPK in breast cancer. | 27145268 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Our research demonstrated that AMPK was up-regulated in breast cancer tissues and cell lines, especially in triple negative breast cancer (TNBC). | 27145268 |
| Breast Carcinoma | Deregulated Nutrient Sensing | High-expression of AMPK correlated with poor outcome in both total breast cancer and TNBC patients. | 27145268 |
| Neoplasms | Deregulated Nutrient Sensing | Our study provides evidence that mir-101-3p- AMPK axis could be a promising therapeutic target in TNBC targeting tumor metabolism. | 27145268 |
| Neoplasm Metastasis, Colorectal Carcinoma | Deregulated Nutrient Sensing | Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. | 27145368 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Further dual-luciferase reporter gene assays revealed that SIRT1 was the direct target of miR-199b in CRC. | 27145368 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | The expression of miR-199b was inversely correlated with SIRT1 in CRC specimens. | 27145368 |
| Neoplasm Metastasis | Deregulated Nutrient Sensing | Furthermore, through Human Tumor Metastasis PCR Array we discovered KISS1 was one of the downstream targets of SIRT1. | 27145368 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Thus, we concluded that miR-199b regulates SIRT1/CREB/KISS1 signaling pathway and might serve as a prognosis marker or a novel therapeutic target for patients with CRC. | 27145368 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | Hypertension and dyslipidaemia were the most common cardiovascular comorbidities, present in 2920 (51.0%) and 2664 patients (46.6%) respectively. | 27146460 |
| Apolipoproteins, Postmenopausal state, Obesity, Abdominal | Deregulated Nutrient Sensing | Postmenopausal hypertension, abdominal obesity, apolipoprotein and insulin resistance. | 27149156 |
| diabetic | Deregulated Nutrient Sensing | Impact of Physical Activity on Glycemic Control and Insulin Resistance: A Study of Community-dwelling Diabetic Patients in Eastern China. | 27150854 |
| Dyslipidemias, Atrial Fibrillation by ECG Finding, Cerebrovascular accident | Deregulated Nutrient Sensing | The post-intervention group had higher rates of dyslipidemia and minor stroke [defined as National Institutes of Health Stroke Scale (NIHSS) <= 3]; less frequent atrial fibrillation; higher numbers of current smokers, heavy drinkers, referrals, and multi-model head imaging cases; and lower NIHSS scores and blood sugar level (all P < 0.05). | 27152854 |
| HD Term Type | Deregulated Nutrient Sensing | Linear and stepwise multivariable adjustment analyses revealed that insulin resistance and the o-6/o-3 PUFA ratio were the independent deleterious determinants of ASM normalized to height in HD patients. | 27157471 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | As a low-pigment skin type is prevalent in men and women with type 1 diabetes, it is possible that skin pigmentation may be associated with insulin resistance. | 27161346 |
| Dyslipidemias, Diabetes Mellitus, Atrial Fibrillation by ECG Finding, Cardiovascular Diseases | Deregulated Nutrient Sensing | Secondary variables: gender, atrial fibrillation, diabetes mellitus, dyslipidemia, cardiovascular disease, age and the physician having attended a cardiovascular training course (ESCARVAL). | 27163781 |
| Congenital Generalized Lipodystrophy Type 1, No metabolic abnormalities | Deregulated Nutrient Sensing | Our data indicate that patients with congenital generalized lipodystrophy type 4 should be meticulously evaluated for cardiac, neuromuscular, gastrointestinal and skeletal diseases, as well as metabolic abnormalities associated with insulin resistance. | 27167729 |
| Inflammation, Non-alcoholic Fatty Liver Disease, Prediabetes syndrome | Deregulated Nutrient Sensing | Subclinical inflammation in relation to insulin resistance in prediabetic subjects with nonalcoholic fatty liver disease. | 27169860 |
| Inflammation, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | However, very limited data are available regarding the association of subclinical inflammation and insulin resistance with NAFLD in a prediabetic state. | 27169860 |
| Inflammation, Non-alcoholic Fatty Liver Disease, Prediabetes syndrome | Deregulated Nutrient Sensing | Subclinical chronic inflammation and insulin resistance seem to be independent mediators of the association between NAFLD and prediabetes. | 27169860 |
| Dyslipidemias, Prediabetes syndrome | Deregulated Nutrient Sensing | The data also indicate that the inflammatory condition and insulin resistance are associated with each other and these, in turn, are affected by adiposity and dyslipidemia in prediabetic subjects. | 27169860 |
| Cortical malformations, Epilepsy | Deregulated Nutrient Sensing | GATOR1 complex gene mutations leading to mTORC1 pathway upregulation is an important cause of focal epilepsy with cortical malformations and represents a potential target for novel therapeutic approaches. | 27173016 |
| Pancreatitis | Deregulated Nutrient Sensing | Increased insulin resistance and reduced insulin clearance may be important components of hyperinsulinemic compensation in patients after acute pancreatitis. | 27173509 |
| Inflammation | Deregulated Nutrient Sensing | Our data suggest that both low and high birth weights are associated with greater visceral adiposity and biomarkers implicated in insulin resistance and inflammation in adolescents. | 27174144 |
| Chronic Kidney Insufficiency, Dyslipidemias, Coronary heart disease, Peripheral Vascular Diseases, Tobacco, Cardiovascular system | Deregulated Nutrient Sensing | The patients of group 2 had significantly more risk factors and cardiovascular comorbidities (coronary disease, tobacco addiction, dyslipidemia, peripheral arterial disease, chronic renal insufficiency). | 27174351 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Oral administration of nicotinamide riboside, a natural NAD(+) precursor, completely corrected these NAFLD phenotypes induced by NAD(+) deficiency alone or HFD, whereas adenovirus-mediated SIRT1 overexpression only partially rescued these phenotypes. | 27174364 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Independent predictors of low-density lipoprotein cholesterol < 70 mg/dL were diabetes mellitus, wholegrain bread, shorter history of dyslipidemia, and, especially, high-intensity cholesterol-lowering therapies. | 27178117 |
| Fanconi Anemia | Deregulated Nutrient Sensing | Endocrinopathies, Bone Health, and Insulin Resistance in Patients with Fanconi Anemia after Hematopoietic Cell Transplantation. | 27180116 |
| Diabetes Mellitus, Non-Insulin-Dependent, Disease | Deregulated Nutrient Sensing | Obesity-associated insulin resistance in type 2 diabetes is a disorder in the balance between pro-inflammatory and anti-inflammatory signals. | 27182056 |
| Inflammation, Overweight | Deregulated Nutrient Sensing | Resting Heart Rate Variability, Inflammation, and Insulin Resistance in Overweight and Obese Adolescents. | 27182718 |
| Inflammation, Autonomic nervous system disorders | Deregulated Nutrient Sensing | Chronic low-grade inflammation, insulin resistance, and autonomic dysfunction are present at an early age in obese youths; early detection of inflammation may facilitate meaningful lifestyle changes in this high-risk group. | 27182718 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin Resistance and Diabetes Mellitus in Contemporary Cardiac Rehabilitation. | 27182762 |
| Diabetes Mellitus, Non-Insulin-Dependent, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The goal of this study was to determine the prevalence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) in contemporary cardiac rehabilitation (CR) and to compare clinical responses in CR between these subsets of patients with coronary heart disease (CHD). | 27182762 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prior studies conducted in Greece consistently indicate that dyslipidemia is suboptimally managed, while the burden of cardiovascular disease (CVD) and related risk factors is rising. | 27183455 |
| Chronicity, Dyslipidemias | Deregulated Nutrient Sensing | Independent risk factors for chronicity were older age [OR: 1.06, p=0.011], dyslipidemia [OR: 4.26, p=0.04] and severe DILI [OR: 14.22, p=0.005]. | 27184533 |
| Dyslipidemias | Deregulated Nutrient Sensing | One year is the best cut-off point to define chronic DILI or prolonged recovery, with risk factors being older age, dyslipidemia and severity of the acute episode. | 27184533 |
| Chronicity, Dyslipidemias | Deregulated Nutrient Sensing | Risk factors for DILI chronicity are older age, dyslipidemia and severity of the acute episode. | 27184533 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Circulating serum FGF19 concentrations were decreased (P < 0.01) similarly in obese patients regardless of their degree of insulin resistance, while FGF21 levels were increased in obesity (P < 0.01), being further increased in obesity-associated T2D (P < 0.01). | 27188262 |
| Steatohepatitis | Deregulated Nutrient Sensing | Increased hepatic steatosis was significantly associated with the presence of T2DM, and insulin resistance induced by hepatic fat may be an important mechanistic connection. | 27189281 |
| Obesity | Deregulated Nutrient Sensing | Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population. | 27189377 |
| Obesity | Deregulated Nutrient Sensing | Confirmatory associations were also observed between leptin and obesity, blood lipids and insulin resistance for the first time in an African population. | 27189377 |
| Obesity | Deregulated Nutrient Sensing | Gender was significant covariate interacting with insulin sensitivity/insulin resistance and obesity indexes associations in this population. | 27189377 |
| Inflammation, Dyslipidemias, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes, dyslipidaemia, inflammation and mineral-bone disorders play a role in the appearance of PAD in CKD. | 27190385 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Add-on treatment with intermediate-acting insulin versus sliding-scale insulin for patients with type 2 diabetes or insulin resistance during cyclic glucocorticoid-containing antineoplastic chemotherapy: a randomized crossover study. | 27191794 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Diagnosis of hypertension at follow-up among subjects normotensive at baseline was independently associated with obesity at baseline (relative risk (RR) = 1.40 [1.12-1.75] for BMI between 27 and 30 kg/m2 and 1.72 [1.33-2.25] for BMI >=30 kg/m2 as compared with BMI <27 kg/m2) and HbA1C (RR =1.12 [1.05-1.19] per %), suggesting a prominent role of insulin resistance in our population. | 27195533 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | These findings suggest a CD34+/VEGFR2+ EPC mobilization defect in IGT and T2DM that could play a role in the cardiovascular diseases and capillary rarefaction associated with insulin resistance. | 27197857 |
| Inflammation | Deregulated Nutrient Sensing | Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population. | 27199507 |
| Inflammation | Deregulated Nutrient Sensing | The findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population. | 27199507 |
| Benign Paroxysmal Positional Vertigo | Deregulated Nutrient Sensing | In this study, we report that the miR-34a and Sirtuin 1 (SIRT1) genes correlated with the treatment effects of CRP in BPPV subjects. | 27203679 |
| Benign Paroxysmal Positional Vertigo | Deregulated Nutrient Sensing | We found that miR-34a expression was largely inhibited and SIRT1 expression was significantly reversed after BPPV maneuver treatment. | 27203679 |
| Benign Paroxysmal Positional Vertigo | Deregulated Nutrient Sensing | We conclude that BPPV treatment might involve some epigenetic regulations through the mediation of miR-34a, SIRT1 functions and repression of redox status. | 27203679 |
| Dyslipidemias, Transaminases | Deregulated Nutrient Sensing | Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. | 27203747 |
| Liver damage, Overweight, Dyslipidemias | Deregulated Nutrient Sensing | The increase in overweight and obese children may be linked to increased rates of liver damage and dyslipidaemia. | 27203747 |
| Dyslipidemias | Deregulated Nutrient Sensing | This study aimed to explore the associations of liver biomarkers with overweight/obesity and dyslipidaemia in Mexican children. | 27203747 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Children with high ALT (defined as >=P75) showed higher prevalence of dyslipidaemia than their counterparts, with high prevalence of high TChol (P = 0.053), non-HDL-chol, TG, and low HDL-chol. | 27203747 |
| Dyslipidemias, Myocardial Ischemia, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Additionally they were more likely to have history of ischemic heart disease, diabetes, dyslipidemia, and less likely to have chronic kidney disease (p < 0.001 for all comparisons). | 27206336 |
| Glucose Intolerance (disease), Polyneuropathy | Deregulated Nutrient Sensing | Although the reduction of IENFD becomes evident as polyneuropathy becomes severe, the effects of glucose intolerance should also be considered in patients with moderate to severe reductions. | 27206908 |
| Dyslipidemias, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Dyslipidemia is a pivotal risk factor for coronary heart disease (CHD). | 27206944 |
| Dyslipidemias | Deregulated Nutrient Sensing | The purpose of this study was to identify the profile of dyslipidemia in a Brazilian population, according to high low-density lipoprotein (LDL-C) levels. | 27206944 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We recently discovered the presence of multiple Toll-like receptor 4 (TLR4) signaling intermediates in leukocytes from patients with type 2 diabetes or acute insulin resistance associated with cardiopulmonary bypass surgery. | 27207509 |
| Overweight, Cardiovascular Diseases | Deregulated Nutrient Sensing | Risk of insulin resistance, impaired glycemic control, and cardiovascular disease is excessive in overweight and obese populations. | 27207552 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes (T2D) is a heterogeneous disorder with contributions from peripheral insulin resistance and b-cell dysfunction. | 27207554 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A protective effect could possibly be masked by a smoking-induced aggravation of insulin resistance, akin to the diabetogenic effect seen in individuals with type 2 diabetes. | 27208379 |
| Dyslipidemias | Deregulated Nutrient Sensing | Therefore, glucose fluctuations may be an important target for secondary prevention after coronary stenting, which is independent of dyslipidemia control. | 27208906 |
| Hepatobiliary Disorder, Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD), a main liver disease around the world, is closely associated with insulin resistance, type 2 diabetes mellitus (T2DM) and other metabolic diseases. | 27211699 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Aspartame intake is associated with greater glucose intolerance in individuals with obesity. | 27216413 |
| Pulmonary Hypertension | Deregulated Nutrient Sensing | Protective Roles of Endothelial AMP-Activated Protein Kinase Against Hypoxia-Induced Pulmonary Hypertension in Mice. | 27217398 |
| Pulmonary arterial hypertension, Polycyclic Hydrocarbons, Aromatic | Deregulated Nutrient Sensing | However, the role of endothelial AMPK in the pathogenesis of pulmonary arterial hypertension (PAH) remains to be elucidated. | 27217398 |
| Hypoxia, Pulmonary Hypertension | Deregulated Nutrient Sensing | Immunostaining showed that endothelial AMPK is downregulated in the pulmonary arteries of patients with PAH and hypoxia mouse model of pulmonary hypertension (PH). | 27217398 |
| Hypoxia | Deregulated Nutrient Sensing | To elucidate the role of endothelial AMPK in PH, we used endothelial-specific AMPK-knockout mice (eAMPK(-/-)), which were exposed to hypoxia. | 27217398 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes. | 27221093 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Hepatocyte-derived fibrinogen-related protein 1 (HFREP1) is a hepatokine that mediates NAFLD development; however, the role of HFREP1 in the development of insulin resistance and diabetes remains obscure. | 27221093 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These findings highlight the crucial role of HFREP1 in insulin resistance and diabetes, and provide a potential strategy and biomarker for developing therapeutic approaches to combat these diseases. | 27221093 |
| Heart failure | Deregulated Nutrient Sensing | Statin treatment is associated with a negative correlation between NT-proBNP and insulin resistance in patients without history of heart failure. | 27221204 |
| Inflammation, muscle mass | Deregulated Nutrient Sensing | Our results suggested that major contributing factors to PEW were reduced muscle mass, unintentional low dietary energy intake, lower amount of exercise, insulin resistance, and chronic inflammation. | 27222412 |
| Dyslipidemias | Deregulated Nutrient Sensing | RJ supplementation may offer an alternative method of controlling the menopause - associated dyslipidemia. | 27227757 |
| Sleep Apnea, Obstructive, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Obstructive sleep apnea combined dyslipidemia render additive effect on increasing atherosclerotic cardiovascular diseases prevalence. | 27228976 |
| Osage language, Sleep Apnea, Obstructive, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Current study was designed to investigate the effects of obstructive sleep apnea (OSA) combined dyslipidemia on the prevalence of atherosclerotic cardiovascular diseases (ASCVD). | 27228976 |
| Dyslipidemias, Osage language | Deregulated Nutrient Sensing | This was a cross-sectional study and subjects with documented dyslipidemia and without previous diagnosis of OSA were enrolled. | 27228976 |
| Osage language, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Logistic regression analysis revealed that in unadjusted model, compared to dyslipidemia plus no-OSA group (reference group), OSA enhanced ASCVD risk in subjects with dyslipidemia, regardless of OSA severity. | 27228976 |
| Dyslipidemias, Osage language | Deregulated Nutrient Sensing | OSA combined dyslipidemia conferred additive adverse effects on cardiovascular system, with severe-OSA most prominent. | 27228976 |
| Vascular System Injuries | Deregulated Nutrient Sensing | The association between PWV and the loss of dipping and insulin resistance levels, independently of the BMI, reinforces the contribution of these comorbidities to vascular injury in early life. | 27232909 |
| Dilated Cardiomyopathy Pathway | Deregulated Nutrient Sensing | De novo RRAGC mutation activates mTORC1 signaling in syndromic fetal dilated cardiomyopathy. | 27234373 |
| Heart failure, Syndrome | Deregulated Nutrient Sensing | These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes. | 27234373 |
| Carotid Atherosclerosis | Deregulated Nutrient Sensing | The triglyceride/HDL cholesterol ratio, as a surrogate marker of insulin resistance, may be associated to presence of subclinical carotid atherosclerosis in postmenopausal women. | 27236636 |
| Dental Plaque | Deregulated Nutrient Sensing | In postmenopausal women in primary prevention, insulin resistance, estimated from the triglyceride/HDL-C ratio, was independently associated to a greater probability of carotid plaque. | 27236636 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | However, gender (OR = 1.475, p < 0.001), aging (OR = 1.283, p < 0.001), dyslipidemia (OR = 1.544, 95%CI: 1.315, 1.814, p < 0.001) and hyperglycemia (OR = 1.247, 95%CI: 1.068, 1.455, p = 0.005) was associated with increased risk of mild reduced eGFR. | 27240390 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Predictors of non-response were high BMI, insulin resistance, significant fibrosis and inadequate compliance. | 27241647 |
| Dyslipidemias, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Elevated serum FABP4 level is associated with obesity, insulin resistance, dyslipidemia, and atherosclerosis. | 27241838 |
| Dyslipidemias | Deregulated Nutrient Sensing | Circulating FABP4 is independently associated with the PCSK9 level, suggesting that elevation of FABP4 level as an adipokine leads to dyslipidemia through increased PCSK9 level and subsequent degradation of the LDL receptor. | 27241838 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The mean GA/HbA1c ratio was 2.81+-0.38, and it significantly increased with the presence of glucose intolerance (all, P<0.05). | 27242118 |
| Autoimmune Thyroid Disease Pathway | Deregulated Nutrient Sensing | Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease. | 27245255 |
| Autoimmune Diseases | Deregulated Nutrient Sensing | Sirtuin1 (SIRT1) is a Class 3 nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) that is thought to be implicated in the protection against autoimmune diseases. | 27245255 |
| Autoimmune Thyroid Disease Pathway, Vitamin D measurement | Deregulated Nutrient Sensing | However, an association between SIRT1 and autoimmune thyroid disease (AITD) has not been reported. | 27245255 |
| HD Term Type | Deregulated Nutrient Sensing | We also measured the levels of SIRT1 mRNA in CD4(+) T cells from 18 control subjects, 16 patients with GD in remission and 14 patients with mild HD using a real-time PCR method. | 27245255 |
| Neoplasms | Deregulated Nutrient Sensing | Our results propose that HSP60 silencing disrupts the integrity of the respiratory complex I and triggers the excessive ROS production, which promotes tumor progression in the following aspects: (1) ROS activates the AMPK pathway that promotes acquisition of the Warburg phenotype in HSP60-KN cells; (2) ROS generated by HSP60 knockdown or by rotenone inhibition drives cells to undergo EMT; and (3) the high level of ROS may also fragment the Fe-S clusters that up regulates ADHFe1 expression and the 2-hydroxygluterate (2-HG) production leading to changes in DNA methylation. | 27246978 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis. | 27247228 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | The results suggest that miR-34a has a crucial role in the pathogenesis of OA through direct regulation of the SIRT1/p53 signaling pathway and serves as a potential therapeutic target of OA. | 27247228 |
| Cataract, Arthritis, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, arthritis, and dyslipidemia were associated with cataract surgery at least in one of these LRAs. | 27247507 |
| Presenile dementia, Demographics Domain | Deregulated Nutrient Sensing | Insulin resistance is considered to play an important role in the associations between DM and dementia. | 27250528 |
| Damage | Deregulated Nutrient Sensing | Evolution of target organ damage and haemodynamic parameters over 4 years in patients with increased insulin resistance: the LOD-DIABETES prospective observational study. | 27251684 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | However, the effect of dyslipidemia on acute ischemic stroke is unclear. | 27256172 |
| Dyslipidemias, Progressive neurologic deterioration, Ischemic stroke, Endoglin, human | Deregulated Nutrient Sensing | We hypothesized that dyslipidemia could contribute to early neurological deterioration (END) after ischemic stroke. | 27256172 |
| Proteinuria, Gout, Dyslipidemias, Congestive heart failure, Acute Kidney Injury, CTCAE, Coronary Artery Disease | Deregulated Nutrient Sensing | Data regarding various predictors such as age, sex, race, proteinuria, medication use, contrast exposure, acute kidney injury episodes, coronary artery disease, congestive heart failure, dyslipidemia, gout etc. | 27257659 |
| Dyslipidemias, Coronary Artery Disease | Deregulated Nutrient Sensing | Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India. | 27257688 |
| Dyslipidemias, Obesity, Coronary heart disease | Deregulated Nutrient Sensing | While the prevalence of chronic ischemic coronary disease, dyslipidemia, smokers and obesity, was lower. | 27257851 |
| Weight decreased | Deregulated Nutrient Sensing | The specific type of BS is a determinant of monocyte count variation independent of the amount of weight loss or the degree of insulin resistance improvement. | 27260650 |
| Normokalemic Periodic Paralysis, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | We aimed to investigate the effects of potassium supplementation and alkali supplementation in non-acidotic, normokalemic humans with combined glucose intolerance. | 27260862 |
| Glucose Intolerance (disease), Ovarian failure | Deregulated Nutrient Sensing | Glucose intolerance and compensatory pancreatic b-cell mass caused by GC were not modified by ovarian failure in the VCD+DEX group. | 27264932 |
| Lipodystrophy, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | HIV patients on highly-active antiretroviral therapy (HAART) have shown elevated incidence of dyslipidemia, lipodystrophy, and markers of cardiovascular disease. | 27270208 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Mild subclinical hypothyroidism (SCH) affects a large number of people and is known to be a risk factor for dyslipidemia. | 27270263 |
| TG gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine the effects of volanesorsen (ISIS 304801), a second-generation 2'-O-methoxyethyl chimeric antisense inhibitor of apolipoprotein (apo)C-III, on triglyceride (TG) levels and insulin resistance in patients with type 2 diabetes. | 27271183 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes. | 27271183 |
| Alteration, Hyperglycemia | Deregulated Nutrient Sensing | This coupled with the evidence of a strong inverse association with glycaemic indices and insulin resistance postulates the role of mineral alterations in the pathophysiology of hyperglycaemia and insulin resistance. | 27272715 |
| Glucose Intolerance (disease), Pancreatic carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Long-standing diabetes or glucose intolerance is recognized as a crucial event in the process of pancreatic cancer. | 27276680 |
| Hyperglycemia, diabetic | Deregulated Nutrient Sensing | Effects of Long-Term Alpha-mangostin Supplementation on Hyperglycemia and Insulin Resistance in Type 2 Diabetic Rats Induced by High Fat Diet and Low Dose Streptozotocin. | 27276829 |
| Dyslipidemias, Diabetes Mellitus, Retinal Diseases, Peripheral Vascular Diseases, Peripheral Neuropathy | Deregulated Nutrient Sensing | The associated risk factors were the presence of diabetes (OR 1.67 [1.49-1.88] p < 0.001), history of foot ulceration (OR 81 [18.20-360.48] p < 0.001), peripheral arterial disease (OR 31.29 [9.02-108.56] p < 0.001), peripheral neuropathy (OR 31.29 [9.02-108.56] p < 0.001), foot deformity (OR 23.62 [5.82-95.93] p < 0.001), retinopathy (OR 6.08 [2.64-14.02] p < 0.001), dyslipidemia (OR 4.6 [1.05-20.05] p= 0.049) and indigenous background (OR 3.39 [1.38-8.33] p= 0.01). | 27277135 |
| Abnormal renal function, Disorder of macula due to diabetes mellitus, Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | It is evident that diabetic maculopathy has association with dyslipidaemia, abnormal renal function due to nephropathy. | 27277354 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Immunohistochemical expressions of FOXM1, FOXO3a, SIRT1 and SIRT6 were evaluated in tissue microarray blocks containing 688 consecutive breast cancer samples. | 27277416 |
| Triple-Negative Breast Cancer Finding | Deregulated Nutrient Sensing | High expression of FOXM1 was significantly correlated with high SIRT1 and SIRT6 expression, higher histologic grade and triple-negative breast cancer (TNBC). | 27277416 |
| Hepatitis B | Deregulated Nutrient Sensing | Insulin resistance increases loss of antibody to hepatitis B surface antigen in nondiabetic healthy adults. | 27279074 |
| Impaired T cell function | Deregulated Nutrient Sensing | Standard laboratory tests were conducted for insulin resistance and b-cell dysfunction. | 27281097 |
| Aneurysm | Deregulated Nutrient Sensing | In the aorta of smooth muscle cell-specific sirtuin-1-deficient mice, spontaneous aneurysm formation and senescence are observed. | 27283746 |
| Cessation of life, Dyslipidemias, Carcinoma of lung | Deregulated Nutrient Sensing | Long-term statin use in patients with lung cancer and dyslipidemia reduces the risk of death. | 27283991 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose Intolerance after a Recent History of Gestational Diabetes Based on the 2013 WHO Criteria. | 27285104 |
| Gestational Diabetes, Glucose Intolerance (disease), Beta-Cell Function Measurement | Deregulated Nutrient Sensing | Glucose intolerance is very frequent in early postpartum in women with GDM based on the 2013 WHO criteria in a two-step screening strategy and these women have an impaired beta-cell function. | 27285104 |
| Refractory Cytopenia of Childhood, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | Allosteric inhibitors of the mammalian target of rapamycin complex 1 (mTORC1) are approved for advanced renal cell carcinoma (RCC). | 27286790 |
| Obesity | Deregulated Nutrient Sensing | This finding was independent of obesity and insulin resistance. | 27304050 |
| FAI - Free androgen index measurement | Deregulated Nutrient Sensing | Insulin resistance (IR) and free androgen index (FAI) were calculated and compared with age- and sex-matched controls. | 27304785 |
| diabetic, Diabetes Mellitus | Deregulated Nutrient Sensing | Furthermore, diabetic keratinocytes displayed insulin resistance and increased expression of pro-inflammatory cytokines demonstrating the persistent effect of diabetes mellitus on human skin cells. | 27306297 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | The most frequent risk factors were MS and its variables: increased waist circumference, dyslipidemia and HBP. | 27310544 |
| amyloid-beta binding, Dyslipidemias | Deregulated Nutrient Sensing | Although many preclinical studies have suggested the possible linkage between dyslipidemia and cerebral amyloid deposition, the association between serum lipid measures and cerebral amyloid-beta (Ab) deposition in human brain is still poorly known. | 27311886 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Medication and remission results for hypertension and dyslipidemia did not differ significantly between groups. | 27312346 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The purpose of this study is to examine the relations among plasma periostin, glucose and lipid metabolism, insulin resistance and inflammation in Chinese patients with obesity (OB), and type 2 diabetes mellitus (T2DM). | 27313402 |
| TG gene, Inflammation | Deregulated Nutrient Sensing | Plasma periostin levels were strongly associated with plasma TG, chronic inflammation, and insulin resistance. | 27313402 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Effects of prednisolone on energy and fat metabolism in patients with rheumatoid arthritis: tissue-specific insulin resistance with commonly used prednisolone doses. | 27321736 |
| Lipolysis | Deregulated Nutrient Sensing | Attenuated postprandial suppression of fat oxidation, but not lipolysis, suggests that prednisolone causes greater insulin resistance in skeletal muscle than in adipocytes. | 27321736 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia and low levels of high density lipoprotein cholesterol (HDL-C) can increase the risk of atherosclerosis development in people with type 2 diabetes mellitus (T2DM). | 27322526 |
| Coronary heart disease | Deregulated Nutrient Sensing | Ranolazine improves insulin resistance in non-diabetic patients with coronary heart disease. | 27323337 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | The aim of this pilot study was to evaluate if ranolazine (R) could improve insulin resistance (IR) in obese/overweight non-diabetic patients with coronary heart disease (CHD). | 27323337 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Current researcn in type 2 diabetes mellitus focuses on the role of Peroxisome- Proliferator Activated Receptors (PPARs) in the pathogenesis of the Insulin Resistance Syndrome (IRS), which are pre-diabetic lesion and the hallmark of fully developed type 2 diabetes mellitus. | 27323578 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Similarly, the MetS (or its individual components), insulin resistance and increased serum uric acid levels were also independently associated with LSM>7.0 kPa. | 27324703 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Legume consumption and its association with fasting glucose, insulin resistance and type 2 diabetes in the Indian Migration Study. | 27329792 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Although legumes are essential in traditional Indian diets, as well as in prudent and Mediterranean diets in the West, we did not find an association between legumes and markers of glycaemic control, insulin resistance or diabetes, except for subgroups based on BMI and macronutrient intake. | 27329792 |
| Dyslipidemias, Calcinosis | Deregulated Nutrient Sensing | Dyslipidemia, moderate-severe calcification, and first-year AV-Vel progression >=0.22 m/s/year were independent predictors of cardiac events. | 27334030 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Multiple logistic regression analyses showed that dyslipidaemia, BMI and 2-h postprandial plasma glucose were independent risk factors for non-alcoholic fatty liver disease, while heart rate and female gender were protective factors. | 27334577 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Vitamin D3-Supplemented Yogurt Drink Improves Insulin Resistance and Lipid Profiles in Women with Gestational Diabetes Mellitus: A Randomized Double Blinded Clinical Trial. | 27336154 |
| Gestational Diabetes | Deregulated Nutrient Sensing | Daily consumption of VDY drink improves insulin resistance and lipid profiles in women with GDM. | 27336154 |
| Prostate Cancer Outcomes Study, Hyperandrogenism | Deregulated Nutrient Sensing | PCOS patients above the 75th percentile for UFC and/or 17OHS after high-dose dexamethasone (n = 15) had a significantly smaller total adrenal volume (6.9 +- 1.9 cm(3) vs 9.2 +- 1.8 cm(3), P = .003) when compared with the remaining PCOS patients (n = 22), but they did not have worse insulin resistance or hyperandrogenism. | 27336356 |
| Old age | Deregulated Nutrient Sensing | Depletion of SIRT1 by knockdown or SIRT1 inhibitor EX527 abrogated the antisenescence effect of a7nAChR against Ang II. | 27339462 |
| Vascular Diseases | Deregulated Nutrient Sensing | Our results demonstrate that activation of a7nAChR alleviates Ang II-induced VSMC senescence through promoting NAD(+)-SIRT1 pathway, suggesting that a7nAChR may be a potential therapeutic target for the treatment of Ang II-associated vascular aging disorders. | 27339462 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Relationships between insulin resistance and frailty with body composition and testosterone in men undergoing androgen deprivation therapy for prostate cancer. | 27340081 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | ADT is associated with increased insulin resistance and frailty within 12months of commencement, independently of confounding effects of cancer or radiotherapy. | 27340081 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Influence of Insulin Resistance and TNF-a on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis. | 27340510 |
| Refractory anemias, Rheumatoid Arthritis | Deregulated Nutrient Sensing | The aim of this study was to evaluate the involvement of TNF-a and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA). | 27340510 |
| Refractory anemias | Deregulated Nutrient Sensing | Similarly, features of insulin resistance were absent in RA patients (p = non-significant). | 27344073 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The M2BP levels in subjects with hypertension, dyslipidemia, or abnormal glucose metabolism were higher than those in subjects without such risk factors. | 27344370 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial. | 27347563 |
| Blood Glucose | Deregulated Nutrient Sensing | The high FOXC2 expressions in visceral adipose tissues are manifested as reduction of blood glucose and blood lipid levels, thereby reducing insulin resistance. | 27349002 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | We recruited patients with ACS and dyslipidemia who had undergone coronary angiography. | 27349705 |
| fibrillin | Deregulated Nutrient Sensing | Moreover, TH treatment increased intracutaneous fibrillin-rich microfibril and collagen III deposition and decreased mammalian target of rapamycin (mTORC1/2) expression ex vivo. | 27349864 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is frequently associated with insulin resistance (IR) and abnormalities in glucose metabolism. | 27351871 |
| Increased insulin level, Hypoglycemia, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Prevalent postprandial hyperinsulinemia along with insulin resistance in NAFLD may lead to hypoglycemia. | 27351871 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Teneligliptin, a chemotype prolyl-thiazolidine-based novel dipeptidyl peptidase (DPP)-4 inhibitor, was preliminarily shown to reduce insulin resistance in patients with type 2 diabetes mellitus (T2DM). | 27352309 |
| Hyperglycemia, Breast Carcinoma | Deregulated Nutrient Sensing | Consumption of Fresh Yellow Onion Ameliorates Hyperglycemia and Insulin Resistance in Breast Cancer Patients During Doxorubicin-Based Chemotherapy: A Randomized Controlled Clinical Trial. | 27352956 |
| Hyperglycemia | Deregulated Nutrient Sensing | The present study demonstrated the effectiveness of onion to ameliorate hyperglycemia and insulin resistance in BC during doxorubicin-based chemotherapy. | 27352956 |
| hepatitis B virus | Deregulated Nutrient Sensing | Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via DNp63-miR-181a-Sirt1 pathway. | 27354409 |
| Hypermetabolism, Burn Specimen Source Codes, Inflammation, Hyperglycemia | Deregulated Nutrient Sensing | Inflammation and hypermetabolism post burn predisposes to hyperglycemia and insulin resistance. | 27355659 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The occurrence of ChP DNA in the aortic tissue is related to classic CAD risk factors such as diabetes and dyslipidemia. | 27358129 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Gender, smoking, dyslipidemia (DL), and diabetes mellitus (DM), in addition to FMD-AUC120, were identified as significant independent variables that predicted the presence of CAD by a multivariate logistic regression. | 27359079 |
| Dyslipidemias, Diabetes Mellitus, Heart Diseases, Hepatobiliary Disorder, Kidney Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | There were no obvious differences in age, gender ratio, body mass index, hypertension, dyslipidemia, diabetes, kidney disease, liver disease, heart disease, or drinking or smoking habits between carriers and non-carriers. | 27365075 |
| Endothelial dysfunction, Atherosclerosis | Deregulated Nutrient Sensing | Angiopoietin-like protein 2 (ANGPTL2), a proinflammatory mediator, has been reported to accelerate the development of insulin resistance, endothelial dysfunction, and atherosclerosis in mice. | 27365403 |
| Inflammation | Deregulated Nutrient Sensing | Chronic low-grade inflammation and insulin resistance are intimately related entities that are common to most, if not all, chronic diseases of affluence. | 27366752 |
| Mood Disorders, Dyslipidemias, Metabolic Syndrome X, Obesity | Deregulated Nutrient Sensing | Affective disorders are associated with increased frequencies of CVD risk-factors such as obesity, dyslipidemia, and metabolic syndrome. | 27367307 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | However, the role of Sirt1 in the OA chondrocytes still remains unknown. | 27367673 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | The expression of Sirt1 was ubiquitously observed in osteoarthritic chondrocytes; in contrast, Runx2 expressed in the osteophyte region in patients with OA and OA model mice. | 27367673 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | OA chondrocytes, which were pretreated with Sirt1 inhibitor, inhibited the IL-1b-induced expression of Runx2 compared to the control. | 27367673 |
| Degenerative polyarthritis, Inflammation | Deregulated Nutrient Sensing | Since Sirt1 activity is known to be affected by several stresses, including inflammation and oxidative stress, as well as aging, SIRT may be involved in the development of OA. | 27367673 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis. | 27367673 |
| Overweight | Deregulated Nutrient Sensing | Among overweight middle-aged men with glucose-intolerance, ILS increased endogenous testosterone slightly but without significant improvements in mood. | 27371769 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The investigated risk factors were hypertension, hyperglycaemia, and dyslipidaemia. | 27372206 |
| Dyslipidemias | Deregulated Nutrient Sensing | Of those with a recorded assessment, elevated BGL (39%, 479/1,244), smoking (63%, 649/1,033), overweight/obesity (51%, 381/743) and dyslipidaemia (73%, 458/625) were common. | 27372907 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | The difference suggest that postprandial lipid induced glucose intolerance (LGIT) may serve as a further valuable marker for early diabetes prediction. | 27373781 |
| Diffuse Large B-Cell Lymphoma | Deregulated Nutrient Sensing | The PI3K-mTORC pathway is upregulated in diffuse large B-cell lymphoma (DLBCL) and can be targeted with the mTOR complex 1 (mTORC1) inhibitor everolimus. | 27374464 |
| Diffuse Large B-Cell Lymphoma | Deregulated Nutrient Sensing | The mTORC1 inhibitor everolimus given for 14 days in combination with R-CHOP-21 for patients with DLBCL is safe. | 27374464 |
| Renal Insufficiency, Inflammation, Thyroid dysfunction | Deregulated Nutrient Sensing | Our results are as follows: (1) 25-(OH)D was significantly lower than expected (19.48+-9.51 and 18.01+-9.01 (ng/mL+SD) in males and females, respectively); (2) seasonal variation of 25-(OH)D was observed in both sexes (females < males), with values peaking in August; (3) a decline of 25-(OH)D was evident with advancing age, with lower levels in females compared to males up to menopause and no apparent difference between the genders thereafter; (4) levels of 25-(OH)D were lower in renal function impairment, diabetes/insulin resistance and inflammation, while no correlation was detectable in thyroid dysfunction; (5) normalization of PTH levels was observed at ~20 ng/mL 25-(OH)D. At the same cut-off level, a significant decrease of all measured bone turnover indices (b-ALP, osteocalcin and CTX) was evident. | 27376424 |
| Abnormal mitochondria in muscle tissue | Deregulated Nutrient Sensing | Both inherited and acquired insulin resistance have been associated with abnormal muscle mitochondrial function. | 27376543 |
| Dyslipidemias, Neurologic Symptoms | Deregulated Nutrient Sensing | Sensitivity analysis in patients with dyslipidemia (n = 1,998) also showed the same trend between pre-stroke statin treatment and mild neurological symptoms (multivariable-adjusted OR 1.26; 95% CI 0.99-1.62; p = 0.06). | 27376661 |
| Dyslipidemias | Deregulated Nutrient Sensing | Age and BMI were positively correlated with increase in the risk of dyslipidemia. | 27377682 |
| Dyslipidemias | Deregulated Nutrient Sensing | Age and BMI are positively correlated with increasing dyslipidemia in my population. | 27377682 |
| Obesity | Deregulated Nutrient Sensing | Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity. | 27378396 |
| Obesity | Deregulated Nutrient Sensing | SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. | 27378396 |
| Obesity | Deregulated Nutrient Sensing | SIRT1 was significantly lower (P = 0.002) and EFT was higher (P < 0.0001) in patients with obesity compared with lean controls. | 27378396 |
| Obesity | Deregulated Nutrient Sensing | SIRT1 showed a negative correlation with EFT and HR in the obesity group (r = -0.350, P = 0.005; r = -0.303, P = 0.008, respectively). | 27378396 |
| Coronary Artery Disease, Obesity | Deregulated Nutrient Sensing | Serum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity. | 27378396 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We used a questionnaire survey for the presence of cerebrovascular risk factors (CVRFs) such as arterial hypertension, smoking and dyslipidemia, among others, as well as instrumental (Doppler examination) and neurological magnetic resonance imaging (MRI) procedures. | 27381108 |
| Non-alcoholic Fatty Liver Disease, diabetic | Deregulated Nutrient Sensing | Our data suggests that SUA is specifically associated with NAFLD in male type 2 diabetic subjects, independent of insulin resistance and other metabolic factors. | 27382573 |
| Dyslipidemias, Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | Regarding the ASCVD risk factors, 17.0% of the study subjects smoked, 5.2% abused alcohol, 2.0% had a family history of ASCVD, 23.3% had diabetes and 96.0% had dyslipidemia. | 27383508 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is a metabolic disease characterized by insulin resistance, and is associated with the effects of genetic and environmental factors. | 27383530 |
| Ulcer, Systemic Scleroderma | Deregulated Nutrient Sensing | Insulin resistance is associated with digital ulcer in patients with systemic sclerosis. | 27383539 |
| Ulcer, Sample Size Calculation, Systemic Scleroderma | Deregulated Nutrient Sensing | To investigate the relationship between insulin resistance and digital ulcers (DUs) in patients with systemic sclerosis (SSc). | 27383539 |
| Sample Size Calculation | Deregulated Nutrient Sensing | Insulin resistance was independently associated with the presence of DUs in patients with SSc and may be a potential biomarker for SSc micro-vasculopathy. | 27383539 |
| Dyslipidemias, Depression, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Eighteen (36%) of the patients were current smokers, 10 (20%) had depression, 7 (14%) had dyslipidemia, and 7 (14%) had diabetes mellitus. | 27383930 |
| ARCN1 gene, Dyslipidemias, Depression, CTCAE | Deregulated Nutrient Sensing | Current smoking, depression, and dyslipidemia were more prevalent among the patients with mild-to-moderate COPD than among those with severe-to-very severe COPD (p < 0.001, p = 0.008, and p = 0.02, respectively). | 27383930 |
| ARCN1 gene, Dyslipidemias, Depression, CTCAE | Deregulated Nutrient Sensing | Certain risk factors for CVD, themselves classified as diseases (including smoking, dyslipidemia, and depression), appear to be more prevalent in patients with mild-to-moderate COPD. | 27383930 |
| Hypertension, CTCAE, Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Hypertension and dyslipidaemia were significantly associated with CHD outcome in males and ABSI (a body shape index) in females. | 27386836 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Acylcarnitines were suggested as early biomarkers even prior to insulin resistance in animal studies, but their roles in predicting type 2 diabetes were unknown. | 27388475 |
| Dyslipidemias, Hepatomegaly | Deregulated Nutrient Sensing | Alterations in glucose homeostasis, dyslipidemia, hepatomegaly and obese phenotype were evident from the very beginning in males with an increased hepatic inflammatory activity. | 27391242 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients' hypertension stage, cardiovascular disease history, diabetes family history, dyslipidemia, and hospital level were associated with higher odds of glucose tests prescription. | 27392259 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Effects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease: assessment of clinical usefulness in CKD patients with atorvastatin (ASUCA) trial. | 27392909 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for the progression of chronic kidney disease (CKD). | 27392909 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of hyperlipidemia (from 13.3%; 95% confidence interval [CI], 11.6%-15.0% to 24.5%; 95% CI, 22.4%-26.6%; P < 0.001) and dyslipidemia (from 18.8%; 95% CI, 16.9%-20.7% to 28.9%; 95% CI, 26.7%-31.3%; P < 0.001) also increased from 2004 to 2014. | 27397598 |
| Diabetes Mellitus, Non-Insulin-Dependent, Myocardial Ischemia | Deregulated Nutrient Sensing | Insulin resistance measured by eGDR could be a useful risk marker in patients with type 2 diabetes and ischemic heart disease. | 27401741 |
| Xanthoma, Dyslipidemias, Sitosterolemia | Deregulated Nutrient Sensing | Infants presenting with multiple xanthomas should be investigated for sitosterolemia, if there is no family history of dyslipidemia. | 27401767 |
| Pancreatitis, Acute, Hyperglycemia | Deregulated Nutrient Sensing | Interleukin-6 is associated with chronic hyperglycemia and insulin resistance in patients after acute pancreatitis. | 27401909 |
| Pancreatitis, Acute, Hyperglycemia | Deregulated Nutrient Sensing | Interleukin-6 appears to be implicated in the development of chronic hyperglycemia and insulin resistance in patients after acute pancreatitis. | 27401909 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Age, cardiovascular risk factors (smoking, systemic arterial hypertension, dyslipidemia and diabetes) and alcohol drinking habit were investigated. | 27402474 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | At baseline, 3 patients had dyslipidemia, 4 had diabetes, and 5 patients had hypertension, which did not change at follow-up. | 27405478 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | We further revealed a novel mechanism in which ICT1 promoted CRC growth via the intracellular AMPK, SAPK/JNK, and PARP signaling pathways. | 27411551 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Anemia, Renal Insufficiency, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients with HFpEF were more likely to be older, female, and have comorbid hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, anemia, and renal dysfunction. | 27413034 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients with mixed dyslipidaemia exhibit low numbers of circulating CD34(+) and CD34(+)/KDR(+) cells as well as CFU-ECs in culture, a defect restored by 3-month treatment with either high-rosuvastatin dose or a combination of low-rosuvastatin dose with o-3 PUFAs. | 27415612 |
| Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus (DM) is a heterogeneous disease characterised by an absolute or relative deficiency of insulin and insulin resistance. | 27416617 |
| Cryoglobulinemia, Lupus Erythematosus | Deregulated Nutrient Sensing | A systemic lupus erythematosus patient presenting as type B insulin resistance complicated with cryoglobulinemia. | 27416845 |
| Cryoglobulinemia, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | We reported a 63-year-old male patient with SLE presenting as type B insulin resistance (TBIR) complicated with cryoglobulinemia. | 27416845 |
| Infertility, Anxiety, CTCAE 3.0 | Deregulated Nutrient Sensing | No statistically significant correlation between BDI or state anxiety and the level of the analyzed hormones, insulin resistance, or infertility treatment, was found. | 27418215 |
| Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Prevalence of dyslipidemia and hypertension were almost 50% higher and prevalence of obesity was two times higher (all p values<0.05). | 27423091 |
| Inflammation, Atherosclerosis, Sleep disturbances, Endothelial dysfunction, Hypertension, CTCAE | Deregulated Nutrient Sensing | Numerous biological pathways linking sleep disturbances to atherosclerosis have been identified, such as insulin resistance, inflammation, hypertension, and endothelial dysfunction. | 27423537 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased iron is associated with type 2 diabetes, dyslipidemia, and high blood pressure. | 27426616 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It has been proposed that the energy-sensing enzyme AMP-activated protein kinase (AMPK) is a key agent in the pathophysiology of type 2 diabetes mellitus (T2DM). | 27427333 |
| Dyslipidemias, Dysglycemia | Deregulated Nutrient Sensing | Dyslipidemia and dysglycemia are etiologically associated, but the direction, chronology, and mechanisms of the association are not fully understood. | 27430991 |
| Dyslipidemias, Dysglycemia | Deregulated Nutrient Sensing | These findings suggest that early lifestyle intervention could ameliorate progressive dyslipidemia and dysglycemia. | 27430991 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The cumulative incidence of de novo diabetes, hypertension, and dyslipidemia were 16.9%, 31.2%, and 6.5%, respectively. | 27434676 |
| Cardiac Arrest, Dyslipidemias | Deregulated Nutrient Sensing | Compared with no-PHAS patients, patients in the PHAS group were predominantly women, and presented more frequently with dyslipidemia and cardiac arrest. | 27436141 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Participants in the top quartile of DASH diet score were 30% less likely to have NAFLD (OR: 0.0.70; 95% CI: 0.61, 0.80); however, more adjustment for dyslipidemia and body mass index changed the association to non-significant (OR: 0.92; 95% CI: 0.73, 1.12). | 27436528 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Reduction Levels and the Effects of High-Molecular-Weight Adiponectin via AMPK/eNOS in Chinese Type 2 Diabetes. | 27437915 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Aim: This study was to investigate the change of high-molecula-weight (HMW) adiponectin (APN) isoform, the association between type 2 diabetes mellitus (T2DM) and HMW APN isoform, the variation of Disulfide-bond A oxidoreductase-like protein (DsbA-L), the effect of HMW APN isoform on AMP-dependent protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS) in Chinese T2DM. | 27437915 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Younger age, obesity, smoking, and uncontrolled dyslipidemia were associated with poor glycemic control. | 27437997 |
| Dyslipidemias | Deregulated Nutrient Sensing | By the other hand, dyslipidemia were more common among monoinfected patients. | 27438424 |
| Proteinuria, Dyslipidemias, Hepatitis C | Deregulated Nutrient Sensing | Although coinfected patients had higher prevalence of tenofovir-based regimen, there was a strong association between hepatitis C virus individuals to pathological proteinuria and dyslipidemia. | 27438424 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We aimed to replicate the associations between an S100A9 variant and insulin resistance and T2D and to initiate an investigation of potential interactions with the habitual diet in several independent populations. | 27440084 |
| Hyperglycemia | Deregulated Nutrient Sensing | This hormonal state may be detrimental for surgical patients due to the presence of insulin resistance and hyperglycemia. | 27442397 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Women were more likely than men to have diabetes mellitus, hypertension, and dyslipidemia, but current smoking was higher in men than in women. | 27442655 |
| Myocardial Ischemia | Deregulated Nutrient Sensing | Insulin resistance (IR), constitutes an important cardiovascular risk factor and can cause ischemic heart disease. | 27448539 |
| Arterial Stiffness, Coronary Artery Disease | Deregulated Nutrient Sensing | Insulin resistance is associated with subclinical myocardial and vascular alterations in patients without significant coronary artery disease, measured as a reduction of Global Longitudinal Strain, and increased arterial stiffness. | 27448539 |
| Dyslipidemias, Impaired cognition | Deregulated Nutrient Sensing | Treatment of dyslipidemia may be an effective strategy to reduce cognitive decline in older HIV(+) individuals. | 27448678 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | In HD patients, lower plasma adropin concentration is associated with dyslipidemia. | 27449397 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study. | 27450534 |
| Coronary Arteriosclerosis, Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate whether atherogenic dyslipidemia, a dyslipidemic profile combining elevated triglycerides and low high-density lipoprotein (HDL) cholesterol, is predictive of risk of silent myocardial ischemia (SMI) or angiographic coronary artery disease (CAD) in asymptomatic patients with type 2 diabetes. | 27450534 |
| Dyslipidemias | Deregulated Nutrient Sensing | Overall, 60 (5.5 %) patients had atherogenic dyslipidemia (triglycerides >=2.26 mmol/L and HDL cholesterol <=0.88 mmol/L). | 27450534 |
| Dyslipidemias, Retinal Diseases, Peripheral arterial occlusive disease | Deregulated Nutrient Sensing | In multivariate analyses taking into account the parameters associated in univariate analyses with SMI and then CAD, atherogenic dyslipidemia was associated with SMI (odds ratio 1.8[1.0-3.3]), as were male gender (OR 2.1[1.5-2.9]), BMI (OR 0.97[0.94-0.997]), retinopathy (OR 1.4[1.1-1.9]), peripheral occlusive arterial disease (POAD: OR 2.5[1.6-3.8]) and mean blood pressure (OR 1.01[1.00-1.03]); atherogenic dyslipidemia was associated with CAD (OR 4.0[1.7-9.2]), as were male gender (OR 3.0[1.6-5.6]), BMI (OR 0.94[0.90-0.995]), retinopathy (OR 1.7[1.0-2.9], POAD (OR 4.0[2.1-7.4]) and mean blood pressure (OR 1.03[1.01-1.05]). | 27450534 |
| Dyslipidemias | Deregulated Nutrient Sensing | In the subgroup of 584 patients with LDL cholesterol <2.6 mmol/L, atherogenic dyslipidemia was also associated with CAD (OR 3.6[1.5-9.0]). | 27450534 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Atherogenic dyslipidemia was associated with an increased risk of SMI and silent CAD in patients with type 2 diabetes and LDL cholesterol levels <3.35 mmol/L. | 27450534 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Specific management of atherogenic dyslipidemia might help reducing the high residual burden of cardiovascular disease. | 27450534 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Overall, 58.8% of the patients had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1% had a smoking history (current or past), 25.8% had a family history of coronary artery disease (CAD) and 24.1% had a prior history of CAD. | 27451914 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In addition, the estimated indices of baseline insulin resistance increased in group A. Fasting insulin level, body mass index, systolic blood pressure at baseline and the shortening of telomere length were independent risk factors of NAFLD in type 2 diabetes mellitus patients. | 27451965 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus patients who developed NAFLD had more serious insulin resistance compared with those who did not develop NAFLD a long time ago. | 27451965 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | INTRODUCTION Lowering exposure to dyslipidemias is one of the biggest challenges in cardiovascular disease prevention. | 27452484 |
| Kidney Failure, Chronic | Deregulated Nutrient Sensing | Adropin and irisin levels in relation to nutrition, body composition, and insulin resistance in patients with end-stage renal disease on chronic hemodialysis and peritoneal dialysis. | 27452672 |
| Kidney Failure, Chronic, Cachexia | Deregulated Nutrient Sensing | Adropin and irisin should be further investigated as possible markers of cachexia and insulin resistance in patients with ESRD. | 27452672 |
| Atherosclerosis | Deregulated Nutrient Sensing | Excess adipose tissue has been implicated in the pathogenesis of insulin resistance and atherosclerosis and is a key risk factor for blood pressure (BP) elevation. | 27455039 |
| ACACA wt Allele | Deregulated Nutrient Sensing | This was associated with an increase in AMPK and ACC, phosphorylation, and increased fatty acid oxidation, which was prevented by AMPK or Sirt inhibition or silencing. | 27456392 |
| Diabetes Mellitus, Insulin-Dependent, Inflammation, IGHD1-7 gene | Deregulated Nutrient Sensing | Patients with type 1 diabetes (DM1) have distinct gut microbiota in comparison to non-diabetic individuals, and it has been linked to changes in intestinal permeability, inflammation and insulin resistance. | 27456494 |
| Pathology | Deregulated Nutrient Sensing | Furthermore, c-Jun N-terminal kinase activation, which plays a pivotal role in insulin resistance and AD pathologies, is significantly inhibited. | 27457264 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Body circumferences have been proposed as potential anthropometric measures for the assessment of cardiometabolic risk as they are independently associated with insulin resistance and diabetes. | 27457430 |
| Dyslipidemias | Deregulated Nutrient Sensing | The association of BCAAs with lipids or with the risk of metabolic dyslipidemia was analyzed. | 27457614 |
| Dyslipidemias | Deregulated Nutrient Sensing | Elevated serum BCAAs level are positively associated with incident metabolic dyslipidemia. | 27457614 |
| Non-alcoholic Fatty Liver Disease, physiopathological | Deregulated Nutrient Sensing | PFF was independently associated with increased total adiposity but did not correlate with AT dysfunction, insulin resistance and secretion or NAFLD. | 27458255 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance and b-cell function are different between the young and elderly diabetes individuals, which are not well elaborated in the nondiabetic persons. | 27459384 |
| Increased insulin level, Gout, Diastolic dysfunction, Hyperleucinemia, Electrocardiogram: left ventricle hypertrophy (finding), Hypoadiponectinemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The study demonstrated compensatory hyperinsulinemia and insulin resistance, hypoadiponectinemia, hyperleptinemia, left ventricular hypertrophy, diastolic dysfunction, and intact ventricular contractility in patients with type 2 diabetes, gout, and their combination. | 27459761 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Although these had improved slightly from 2009 to 2012, diabetes co-morbidities (hypertension and dyslipidaemia) and complications had also increased. | 27459893 |
| Cerebrovascular Disorders, Diabetes Mellitus | Deregulated Nutrient Sensing | Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. | 27465265 |
| Electrocardiogram: myocardial infarction (finding), Cerebrovascular accident, Diabetes Mellitus, Tacca leontopetaloides, Ischemic stroke, BRCA1 wt Allele | Deregulated Nutrient Sensing | The Insulin Resistance Intervention after Stroke (IRIS) trial recently found that pioglitazone reduced risk for stroke and myocardial infarction in patients with insulin resistance but without diabetes who had had a recent ischemic stroke or transient ischemic attack (TIA). | 27465265 |
| Tacca leontopetaloides, Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | Among patients with insulin resistance but without diabetes who had had a recent ischemic stroke or TIA, pioglitazone decreased the risk of diabetes while also reducing the risk of subsequent ischemic events. | 27465265 |
| Increased insulin level, Damage | Deregulated Nutrient Sensing | Herein, we tried to search the role of hyperinsulinism and insulin resistance as a new predictor of primary AVF failure (pAVFF) that may be a cause of intimal damage. | 27466042 |
| Increased insulin level | Deregulated Nutrient Sensing | Insulin resistance or hyperinsulinism may be a significant cause of pAVFF, which emphasizes the role of endothelium in fistula dysfunction. | 27466042 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Taurine metabolism disturbance is closely linked to obesity, insulin resistance, and diabetes. | 27466884 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Association of obesity with hypertension and dyslipidemia in type 2 diabetes mellitus subjects. | 27477531 |
| Hypertriglyceridemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Dyslipidemia, except for hypertriglyceridemia, was correlated to neither abdominal nor general obesity. | 27477531 |
| Dysglycemia | Deregulated Nutrient Sensing | Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise. | 27477619 |
| Adrenoleukodystrophy | Deregulated Nutrient Sensing | Although the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated. | 27477770 |
| ciliary vesicle | Deregulated Nutrient Sensing | High-intensity interval training (HIIT) has been shown to reduce insulin resistance and other CV disease risk factors to a greater degree than moderate-intensity continuous training (MICT). | 27480182 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common comorbidities were hypertension (54 %), dyslipidemia (33 %), a history of smoking (30 %), and diabetes (26 %). | 27480417 |
| Data types - Address | Deregulated Nutrient Sensing | In conclusion, altered markers including AMPK, ER stress and AD related makers under obese condition could be easily obtained from PBMCs. | 27481183 |
| Dyslipidemias | Deregulated Nutrient Sensing | The Association of Vitamin D Status with Dyslipidaemia and Biomarkers of Endothelial Cell Activation in Older Australians. | 27483306 |
| Dyslipidemias | Deregulated Nutrient Sensing | Higher vitamin D status may protect the endothelium through reduced dyslipidaemia and increased HGF. | 27483306 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Blood examinations revealed an inflammatory reaction, worsened glucose intolerance, and an increased level of serum IgG4 (137 mg/dL). | 27484098 |
| Senile Plaques, Data types - Address | Deregulated Nutrient Sensing | Overall, our results support the hypothesis that the miR-132/212 network, including Sirt1 and likely other target genes, contributes to abnormal Ab metabolism and senile plaque deposition in AD. | 27484949 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | BACKGROUND Human fetuin A (AHSG) has been associated with the development of obesity, insulin resistance, type 2 diabetes mellitus, and atherosclerosis. | 27487851 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Brachial artery flow-mediated dilatation and carotid intima-media thickness in young ED patients with insulin resistance. | 27488226 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Western blot analysis showed that diabetes induces accumulated lipid peroxidation products and escalated AMP-activated protein kinase-LKB1 pathway. | 27488451 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | ALDH2 deficiency potentiates oxidative stress and AMPK phosphorylation induced by diabetes via post-translational regulation of LKB1. | 27488451 |
| Presenile dementia | Deregulated Nutrient Sensing | Insulin resistance (IR) is associated with poor cerebrovascular health and increased risk for dementia. | 27488909 |
| IGHD1-7 gene | Deregulated Nutrient Sensing | Significant insulin resistance was found in DM1 that might be responsible for FGF21 elevation. | 27489983 |
| Mitochondrial Diseases | Deregulated Nutrient Sensing | Conclusions FGF21 elevation may be associated with certain types of mitochondrial disease, and it is influenced by insulin resistance. | 27489983 |
| Obesity | Deregulated Nutrient Sensing | The major adverse consequences of obesity are associated with the development of insulin resistance (IR) and adiposopathy. | 27490249 |
| Certified Midwife | Deregulated Nutrient Sensing | The effects of CM were related to the reduction in p53 acetylation which would be dependent on the enhancement of Sirtuin 1 expression. | 27490266 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Soy isoflavone administration for 12 weeks in women with PCOS significantly improved markers of insulin resistance, hormonal status, triglycerides, and biomarkers of oxidative stress. | 27490918 |
| Inflammation | Deregulated Nutrient Sensing | Biomarkers of subclinical inflammation and increases in glycaemia, insulin resistance and beta-cell function in non-diabetic individuals: the Whitehall II study. | 27491375 |
| Inflammation | Deregulated Nutrient Sensing | Subclinical inflammation is associated with development of increased glycaemia, insulin resistance and beta-cell function in non-diabetic individuals. | 27491375 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | A high serum angiopoietin-like 2 (ANGPTL2) concentration is an independent risk factor for developing diabetes and is associated with insulin resistance and atherosclerosis. | 27491833 |
| Dyslipidemias, Family history | Deregulated Nutrient Sensing | The percentage of patients with possible or probable FH in various countries was examined in the Dyslipidemia International Study (DYSIS). | 27494444 |
| SLC25A20 gene, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (b = 0.64 and 0.63, respectively) in males and diabetes (b = 1.08) followed by smoking (b = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. | 27494449 |
| SLC25A20 gene, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | However, in patients aged >70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females. | 27494449 |
| Hypertensive disease, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Therefore, we reviewed published studies on CVD modifiable risk factors e.g., Type 2 Diabetes Mellitus (T2DM), hypertension (HTN), dyslipidemia and smoking as well as studies on CVDs and conducted a meta-analysis of risk factors and disease prevalence. | 27494706 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | Median (IQR) prevalence of T2DM, HTN, dyslipidemia and smoking were 5.9% (1.97%-8.25%); 15.1% (10.52%-17.60%); 34.35% (10.66%-48.50%) and 40.56% (0.80%-55.95%), respectively. | 27494706 |
| Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of T2DM and dyslipidemia were significantly higher in urban compared to rural populations (13.5 vs 6%, p<0.001; 41.5 vs 30%, p = 0.007, respectively). | 27494706 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | There were 74 eligible studies (outcome: T2DM = 32, HTN = 24, dyslipidaemia = 8 and smoking = 25; CVDs = 10). | 27494706 |
| Dyslipidemias, GDC Comorbidity Terminology, Cerebrovascular accident | Deregulated Nutrient Sensing | Comorbid conditions included dyslipidemia, stroke, and 12 other chronic conditions. | 27495110 |
| Disability, Dyslipidemias, Chronic lung disease, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia, chronic lung disease, stroke, memory-related diseases, and arthritis/rheumatism were associated with BADL disability. | 27495110 |
| Progranulins | Deregulated Nutrient Sensing | Progranulin, an adipokine with proinflammatory and insulin resistance-inducing characteristics, has not been investigated in LD so far. | 27497155 |
| Cognition Disorders, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Cholesteryl Ester Transfer Protein Intimately Involved in Dyslipidemia-Related Susceptibility to Cognitive Deficits in Type 2 Diabetic Patients. | 27497473 |
| Dyslipidemias | Deregulated Nutrient Sensing | Cholesteryl ester transfer protein (CETP) is involved in diabetic dyslipidemia. | 27497473 |
| Cognition Disorders, diabetic | Deregulated Nutrient Sensing | We aim to test the hypothesis that CETP might be of importance in mediating dyslipidemia-related susceptibility to cognitive deficits in diabetic patients. | 27497473 |
| Dyslipidemias, millicurie, diabetic | Deregulated Nutrient Sensing | Dyslipidemia is more common among diabetic patients with MCI; they had a significant increase of serum CETP concentrations, which was negatively correlated with MoCA (r = -0.638; p < 0.001). | 27497473 |
| Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | CETP was intimately involved in dyslipidemia-related susceptibility to cognitive decline, especially memory function in type 2 diabetic patients. | 27497473 |
| Obesity | Deregulated Nutrient Sensing | Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. | 27498874 |
| Obesity | Deregulated Nutrient Sensing | Strikingly, restoring 4E-BP1 expression in male mice protects them against HFD-induced obesity and insulin resistance. | 27498874 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Results Hypertension, dyslipidaemia and type 2 diabetes mellitus were prevalent (>=55% of 40 patients). | 27503947 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Significant differences in EAT thickness were found between patients stratified by NO value, FMD, age, smoking status, dyslipidaemia, type 2 diabetes mellitus and FS. | 27503947 |
| Increased insulin level | Deregulated Nutrient Sensing | Hyperinsulinemia is an adaptive mechanism that enables the maintenance of normoglycemia in the presence of insulin resistance. | 27504013 |
| Increased insulin level | Deregulated Nutrient Sensing | Therefore, glucose maintenance during insulin resistance may depend not only on hyperinsulinemia but also on the ability to suppress glucagon early after glucose intake. | 27504013 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | There were diverse dyslipidemia phenotypes in patients with NAFLD. | 27506745 |
| Hyperlipidemia, Hypertriglyceridemia, Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Combined hyperlipidemia, MetS dyslipidemia, and hypertriglyceridemia were strongly and independently associated with increased risk of NAFLD. | 27506745 |
| Thrombus, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | On multivariate regression analysis, aPL, age, hypertension, dyslipidaemia and baseline C-reactive protein level were independently associated with arterial thrombotic events (all P values < 0.05). | 27510601 |
| Primary malignant neoplasm, Cardiovascular Diseases, ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | The high prevalence of obesity and metS and the observed underlying condition of insulin resistance expose this population to an increased risk of cardiovascular disease and cancer despite the healthy nutritional habits. | 27511705 |
| Inflammation, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | A vegetarian diet may prevent elevation of blood pressures and lower the risk for hypertension through lower degrees of obesity, inflammation, and insulin resistance. | 27512965 |
| Inflammation, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | Vegetarian diets may protect against hypertension beyond lower abdominal obesity, inflammation, and insulin resistance. | 27512965 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Overall, 72.8 and 64.8% of patients had hypertension and dyslipidaemia, respectively; 47.0% had both conditions. | 27512970 |
| Hypertension, CTCAE, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Traditional cardiovascular risk factors, such as hypertension and dyslipidemia, predispose individuals to cardiovascular disease, particularly patients with diabetes. | 27513651 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Variables independently associated (p < 0.05) with sedentariness were age, sex, BMI, central obesity, Mediterranean diet adherence, smoking habit, HDL-cholesterol, triglycerides and dyslipidemia. | 27532610 |
| Gain | Deregulated Nutrient Sensing | The influence of insulin and insulin resistance (IR) on children's weight and fat gain is unclear. | 27534840 |
| Neoplasms | Deregulated Nutrient Sensing | We demonstrated that metformin attenuates ERK signaling by activating AMPK pathway leading to suppression of Snail and Slug resulting in upregulation of crucial tumor suppressor gene E-cadherin. | 27534967 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | To our knowledge this is the first report representing an inverse relationship of AMPK and ERK signaling axis in promoting mesenchymal to epithelial transition (MET) via re-expression of E-cadherin upon metformin treatment thus rationalizing lower incidence of cancer in metformin-administered patients. | 27534967 |
| Hypoglycemia, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Blood Glucose | Deregulated Nutrient Sensing | In patients with type 2 diabetes mellitus (T2DM) inadequately controlled by metformin monotherapy, the addition of alogliptin contributed to clinically significant increases in pulmonary function through regulating glycemia and improving the imbalance of the oxidative-related substances in the serum, without increasing the incidence of hypoglycemia, dyslipidemia, dysarteriotony, and any notable increase in body weight. | 27537577 |
| Cardioembolic stroke, Dyslipidemias, Atrial Fibrillation by ECG Finding, Periventricular white matter hyperdensities | Deregulated Nutrient Sensing | Age, male gender, blood glucose level, arterial fibrillation, dyslipidemia, smoking, NIHSS score, cardioembolic stroke type, and periventricular hyperintensities, but not FT4 or TSH, were significantly associated with poor functional outcome. | 27538607 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Increased resting energy expenditure and insulin resistance in male patients with moderate-to severe obstructive sleep apnoea. | 27539109 |
| Hyalinosis, Systemic | Deregulated Nutrient Sensing | Cellular studies revealed concomitant activation of sirt1 and foxo3a in hAMSC after HFS treatment, which was associated with upregulation of p21 and downregulation of bax and p53. | 27539404 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our aim was to investigate the association between the macrophage-activation marker soluble CD163 (sCD163), adiponectin, C-reactive protein (CRP) and changes in glycaemia, insulin resistance and insulin secretion in individuals at high risk of type 2 diabetes mellitus. | 27541014 |
| Hyperglycemia, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The brain's default mode network (DMN), having a high rate of basal energy metabolism, is vulnerable to altered glucose metabolism in type 2 diabetes mellitus (T2DM) due to insulin resistance and chronic hyperglycemia. | 27543086 |
| Dyslipidemias, Hypertriglyceridemia, Leukopenia | Deregulated Nutrient Sensing | The treatment-related grade 3 AE included hypertriglyceridemia (4/16 patients, 25%), increased alanine aminotransferase, increased aspartate aminotransferase, dyslipidaemia, leukopenia and neutropenia (1/16 patients, 6%), and one of 16 patients experienced grade 4 hypertriglyceridemia. | 27543197 |
| Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Severe/morbid obesity was associated with higher triglycerides, hs-CRP, insulin and insulin resistance, diastolic blood pressure and higher odds of hypertension than grade I obesity both in women and men (all, P<0.05). | 27543708 |
| Diabetes Mellitus, Beta-cell dysfunction | Deregulated Nutrient Sensing | Diabetes was associated with known risk factors (i.e., age, sex, family history for diabetes and increased BMI) and both beta-cell dysfunction and insulin resistance were present. | 27546476 |
| Carcinoma, Pancreatic Ductal | Deregulated Nutrient Sensing | Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma. | 27552832 |
| Aggressive behavior | Deregulated Nutrient Sensing | Insulin resistance is associated with the aggressiveness of PDAC. | 27552832 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Additionally, indexes of insulin resistance and insulin secretion showed the same gene-energy interaction as type 2 diabetes. | 27553771 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | BDNF Val/Met and Met/Met variants (rs6265) decreases the risk for glucose intolerance and type 2 diabetes. | 27553771 |
| Lipid Metabolism Disorders | Deregulated Nutrient Sensing | Serum betatrophin concentrations were higher in T2DM and IGT, and were closely related to glucolipid disorder, insulin resistance, but not related to the first-phase of glucose-stimulated insulin secretion. | 27554132 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Preoperative carbohydrate loading, an important element of the ERAS protocol, has been shown to reduce insulin resistance, but its effects on clinical endpoints in gastric cancer surgery remain controversial. | 27554250 |
| Hypertension, CTCAE, Comorbidity, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Common comorbidities included hypertension (76%), dyslipidemia (52%), and obesity (49%). | 27556897 |
| Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. | 27559927 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is characterized by a relative insulin deficiency or insulin resistance. | 27560635 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Efficient treatment and prevention of insulin resistance is essential to prevent future CHD events. | 27561896 |
| Hypertension, CTCAE, Comorbidity, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common comorbidity was hypertension followed by dyslipidemia and diabetes mellitus. | 27563668 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | NSTEMI and unspecified MI patients had significantly higher prevalence of comorbidities than STEMI patients, except for hypertension and dyslipidemia. | 27564212 |
| Dyslipidemias, PDR gene | Deregulated Nutrient Sensing | Dyslipidemia increased the HR of developing NPDR but not PDR or DME. | 27564383 |
| Diabetic Retinopathy, Hypertension, CTCAE, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Adjustments were made for age, sex, body mass index, hypertension, dyslipidemia, stroke, glycated hemoglobin, current drinking, use of anti-hypertensive agent, use of insulin, use of oral anti-hyperglycemic agent, and diabetic retinopathy. | 27564779 |
| Atherosclerosis, Sarcopenia, Obesity | Deregulated Nutrient Sensing | In addition, elevated PRAL scores were associated with high ASCVD risk independent of obesity, exercise, and insulin resistance, but not sarcopenia. | 27565571 |
| Obesity | Deregulated Nutrient Sensing | Diet-induced acid load was associated with increased risk of CVD, independent of obesity and insulin resistance. | 27565571 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between dyslipidaemia and glycaemic status in patients with Type 2 diabetes mellitus. | 27568669 |
| Dyslipidemias | Deregulated Nutrient Sensing | Hence, this study aimed to determine the relationship between dyslipidaemia and glycaemic status in patients with type 2 DM (T2DM) patients in Hospital Putrajaya, a tertiary endocrine centre in Malaysia. | 27568669 |
| Dyslipidemias | Deregulated Nutrient Sensing | This was a cross sectional, retrospective study of 214 T2DM patients with dyslipidaemia who had visited the endocrine clinic between January 2009 and December 2012. | 27568669 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | This significant association between glycaemic status and dyslipidaemia emphasises the additional possible use of HbA1c as a biomarker for dyslipidaemia as well as a potential indirect predictor of cardiovascular disease (CVD) risk in T2DM patients. | 27568669 |
| Inflammation, Cardiovascular Diseases, Dyslipidemias, Decreased renal function, Hypophosphatemia | Deregulated Nutrient Sensing | In addition to decreased renal function, dyslipidemia, inflammation, and continuing hypophosphatemia were also accompanied by decreased BMD as in cardiovascular disease in KTrs. | 27569941 |
| Prostate Cancer Outcomes Study, Cardiovascular Diseases | Deregulated Nutrient Sensing | PCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age. | 27571188 |
| Prostate Cancer Outcomes Study, Dyslipidemias | Deregulated Nutrient Sensing | Independently of the phenotype, young PCOS patients showed high IR and dyslipidemia. | 27571188 |
| Obesity | Deregulated Nutrient Sensing | As adolescents with obesity and insulin resistance may be refractory to lifestyle intervention therapy alone, additional off-label metformin therapy is often used. | 27571249 |
| Obesity | Deregulated Nutrient Sensing | Therefore, metformin may be useful as an additional therapy in combination with lifestyle intervention in adolescents with obesity and insulin resistance. | 27571249 |
| Malignant neoplasm of liver, Chronic liver disease, Lymphoproliferative Disorder of the Skin | Deregulated Nutrient Sensing | Insulin resistance likely increases the risk of chronic liver disease (CLD) and liver cancer, but long-term prospective studies with measured fasting glucose and insulin are lacking. | 27574287 |
| Malignant neoplasm of liver, Lymphoproliferative Disorder of the Skin, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, elevated fasting glucose and insulin and insulin resistance were independently associated with risk of liver cancer and CLD mortality, suggesting a potentially important etiologic role for insulin and glucose dysregulation even in the absence of diagnosed diabetes. | 27574287 |
| Dyslipidemias, Hypopituitarism, Obesity | Deregulated Nutrient Sensing | In both sexes, the risks of central obesity and dyslipidemia were higher in the hypopituitary group than in the control group. | 27577046 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | When limited to patients with dyslipidemia, nonadherence was related to age (HR = 1.21, 95% CI = 1.07-1.38) and obesity (HR = 1.23, 95% CI = 1.02-1.49). | 27578113 |
| Hypertension, CTCAE, Coronary Artery Disease, Dyslipidemias | Deregulated Nutrient Sensing | Adverse events were seen more frequently in patients with history of hypertension, dyslipidemia and previous coronary artery disease. | 27587928 |
| Dyslipidemias | Deregulated Nutrient Sensing | As a marker of dyslipidemia, the level of non-high-density lipoprotein cholesterol (non-HDL-C) was calculated by subtracting HDL-cholesterol from total cholesterol. | 27589412 |
| Dyslipidemias | Deregulated Nutrient Sensing | An elevated non-HDL-C level was associated with increasing age, increasing BMI, and male gender, and use of inducers enhanced the risk of dyslipidemia. | 27589412 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | While CBZ and VPA are first-line AEDs, medication should be selected by considering risk factors for dyslipidemia, such as age gender, and obesity. | 27589412 |
| Inflammation | Deregulated Nutrient Sensing | These associations persisted in within-pair analysis for monozygotic twins for insulin resistance (P<0.01), inflammation (P=0.03), and blood pressure (P=0.04) suggesting independence from genetic confounding. | 27591698 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Failure (biologic function) | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2D) is a chronic metabolic disease regarded as insulin resistance and progressive failure of b cells. | 27592478 |
| Dyslipidemias | Deregulated Nutrient Sensing | This article reports prevalence of dyslipidemia in the North Indian state of Punjab as part of a large household Non Communicable Disease (NCD) Risk Factor Survey. | 27595388 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Presence of more than 2 morbidities, diabetes and hypertension were significantly associated with all types of dyslipidemia. | 27595388 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Compared to the other groups, heavy smokers had significantly higher prevalence of dyslipidemia (83%), obesity (34%), and elevated glycemic biomarkers. | 27595637 |
| Periodontitis | Deregulated Nutrient Sensing | Severe Periodontitis Is Associated with Insulin Resistance in Non-abdominal Obese Adults. | 27598510 |
| Periodontitis | Deregulated Nutrient Sensing | We hypothesized that insulin resistance, even with normal body weight (body mass index or waist circumference), can aggravate periodontitis severity. | 27598510 |
| Periodontitis, Diabetes Mellitus | Deregulated Nutrient Sensing | We investigated the associations between diabetes, insulin resistance, and severe periodontitis. | 27598510 |
| Periodontitis, Obesity, Abdominal | Deregulated Nutrient Sensing | Subjects with severe periodontitis had significantly higher prevalence of abdominal obesity, serum triglycerides, and insulin resistance (P values of .012, <.001, and .003, respectively). | 27598510 |
| Periodontitis | Deregulated Nutrient Sensing | The prevalence of severe periodontitis increased significantly with increasing insulin resistance (P for trend = .04) in nondiabetic individuals. | 27598510 |
| Periodontitis | Deregulated Nutrient Sensing | Non-abdominally obese subjects with insulin resistance were more likely to have severe periodontitis. | 27598510 |
| Obesity, Abdominal, Periodontal Diseases | Deregulated Nutrient Sensing | Insulin resistance can be considered an independent risk factor of periodontal disease in normal weight population defined by abdominal obesity. | 27598510 |
| millicurie, Data types - Address | Deregulated Nutrient Sensing | These results imply that in AD and MCI insulin resistance with increased plasma insulin and decreased FPIR may be associated with the development of AD and MCI, accompanied with milder influence of low adiponectin levels and atherogenic lipid profile. | 27599805 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Although dyslipidemia is common in CKD patients, we found that significant changes in apolipoproteins were not strictly associated with changes in plasma lipid levels. | 27600335 |
| Dyslipidemias, Hyperuricemia, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Obesity has detrimental effects on various clinical parameters and conditions, resulting in increased risk of hypertension, dyslipidemia, type 2 diabetes mellitus, hyperuricemia, and chronic kidney disease. | 27600639 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic (H) vs non-Hispanic White (NHW) populations. | 27603898 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | sTfR levels could be spuriously elevated in subjects with insulin resistance and without association with the MetS or its components. | 27605239 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is present long before the onset of type 2 diabetes and results not only from inherited and lifestyle factors but also likely from environmental conditions. | 27605624 |
| Chronic kidney disease stage 5, Dyslipidemias, Chronic Kidney Diseases, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is one of the cardiovascular risk factors responsible for cardiovascular disease and rapid progression of chronic kidney disease (CKD) to end stage renal disease. | 27605724 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Early detection and management of dyslipidaemia will reduce cardiovascular burden and retard progression of CKD. | 27605724 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | To determine the prevalence and pattern of dyslipidaemia in pre-dialysis CKD patients in a tertiary hospital in southern Nigeria. | 27605724 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The overall prevalence of dyslipidaemia in the CKD patients was 60% which was significantly higher than 39% in the control (p=0.002). | 27605724 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia was commoner in female CKD patients (p=0.02) and those who were >= 45years (p=0.94). | 27605724 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is common in pre-dialysis CKD especially in female and older patients. | 27605724 |
| Refractory anemias, Carotid Atherosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | A multivariable analysis, adjusted for standard cardiovascular risk factors, was performed to evaluate the influence of PCSK9 on RA related dyslipidaemia and subclinical carotid atherosclerosis. | 27606890 |
| Lichen Planus, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Epicardial fat tissue thickness is increased in patients with lichen planus and is linked to inflammation and dyslipidemia. | 27609552 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Exon 3 methylation positively correlated with TG concentration (r=0.359, P=0.003) and with a lipoprotein profile associated with atherogenic dyslipidaemia. | 27613158 |
| Hyperhomocysteinemia, Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus, P mitrale (finding), Cerebrovascular accident, Hyperuricemia, Obesity | Deregulated Nutrient Sensing | Empty nest elderly showed no more risk for comorbidities such as general obesity, abdominal obesity, hyperuricemia, hyperhomocysteinemia, diabetes, dyslipidemia, left atrial enlargement (LAE), and stroke. | 27618905 |
| Dyslipidemias | Deregulated Nutrient Sensing | We investigated to achieve accurate and up-to-date information on the prevalence of dyslipidemia and its associations with other lipid-related diseases in rural North China. | 27619340 |
| Dyslipidemias | Deregulated Nutrient Sensing | The odds ratios between dyslipidemia types and lipid-related diseases were further analyzed by logistic regression. | 27619340 |
| Demographics Domain, Atherosclerosis, Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Hyperuricemia | Deregulated Nutrient Sensing | For subjects with dyslipidemia, the risk for non-alcoholic fatty liver disease (NAFLD) was highest with a 3.3-fold over that of non-dyslipidmia (OR = 3.30, P < 0.001); followed by hyperuricemia and diabetes mellitus (DM), while with 2-fold increase (OR = 1.99, P < 0.001; OR = 1.92, P < 0.001); with only 1.5-fold risk for atherosclerosis (AS) (OR = 1.47, P < 0.001). | 27619340 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In addition to appropriate glycemic control, multi-factorial intervention for a wide range of risk factors, such as hypertension and dyslipidemia, is crucial for management of diabetes. | 27619983 |
| Arterial Stiffness, Hypertension, CTCAE | Deregulated Nutrient Sensing | Pharmacological activation of SIRT1 may be an effective therapeutic strategy for arterial stiffness and hypertension. | 27620389 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia and diabetes were also independent factors for SUA and CUA, respectively. | 27621185 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Although the etiology of these complications is unclear, we propose that glucose intolerance may be a predisposing factor. | 27624504 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Circulating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans. | 27624997 |
| Mice, Inbred NOD, Cognitive | Deregulated Nutrient Sensing | These data indicate that insulin resistance in non diabetic obese children is associated with both cognitive fatigue and reduced motivation/anhedonia and with alterations in tryptophan metabolism. | 27627133 |
| Fatigue | Deregulated Nutrient Sensing | Further investigations are needed to determine whether inflammation-induced alterations in tryptophan metabolism is directly or indirectly implicated in insulin resistance and related fatigue. | 27627133 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia in obese SCH women is not severe, but if untreated for many years, it may lead to atherosclerosis. | 27629733 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes, hypertension, and dyslipidemia were significantly higher in the very high risk group than in the low risk group. | 27629948 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The prevalence of diabetes and dyslipidemia were significantly higher in evacuees than in non-evacuees in only the low risk group. | 27629948 |
| Adipose tissue | Deregulated Nutrient Sensing | Endotrophin levels correlated with adipose tissue mass, insulin resistance and fatty liver index. | 27631136 |
| Coronary Stenosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. | 27633375 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is one of the most important contributing factors to cardiovascular disease. | 27633375 |
| Coronary Stenosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This study aimed to investigate the association between coronary artery stenosis (CAS) and triglyceride glucose index (TyG index), a simple insulin resistance marker, in asymptomatic subjects with type 2 diabetes. | 27633375 |
| Dyslipidemias | Deregulated Nutrient Sensing | For dyslipidemia, vitamin D deficiency has been associated with higher low density lipoprotein-cholesterol (LDL-C) in a number of studies, but with inconsistent results in clinical trials. | 27633775 |
| Hyperglycemia, Hypoglycemia | Deregulated Nutrient Sensing | Type B insulin resistance syndrome is a rare disease that occurs due to the development of autoantibodies to the insulin receptor and can result in either severe insulin resistance and hyperglycemia or, conversely, hypoglycemia. | 27636019 |
| Weight decreased, Diabetic Ketoacidosis | Deregulated Nutrient Sensing | A 39-year-old Nigerian woman presented with significant weight loss, severe diabetic ketoacidosis, and severe insulin resistance requiring massive doses of exogenous insulin. | 27636019 |
| Lupus Erythematosus | Deregulated Nutrient Sensing | She was diagnosed with systemic lupus erythematosus and type B insulin resistance syndrome. | 27636019 |
| Diabetic Ketoacidosis, Diabetes Mellitus | Deregulated Nutrient Sensing | We report a case of severe type B insulin resistance syndrome complicated by severe diabetic ketoacidosis soon after the initial diagnosis of diabetes, despite large doses of exogenous insulin therapy. | 27636019 |
| Malignant neoplasm of endometrium, Neoplasms | Deregulated Nutrient Sensing | Our study shows a marked loss of AMP-activated protein kinase (AMPK) phosphorylation and nuclear human Forkhead box O1 (FOXO1) protein in estrogen-dependent endometrial cancer (EC) tumors compared to normal control endometrium. | 27636742 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Metformin inhibits estrogen-dependent endometrial cancer cell growth by activating the AMPK-FOXO1 signal pathway. | 27636742 |
| Neoplasms | Deregulated Nutrient Sensing | A xenograft mouse model further revealed that metformin suppressed HEC-1B tumor growth, accompanied by downregulated ki-67 and upregulated AMPK phosphorylation and nuclear FOXO1 protein. | 27636742 |
| Rheumatoid Factor | Deregulated Nutrient Sensing | Improvement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study. | 27638812 |
| Refractory anemias | Deregulated Nutrient Sensing | To determine the change in established biomarkers of cardiovascular (CV) risk, namely, total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDL-C), N-terminal pro-brain natriuretic peptide (NT-proBNP) and insulin resistance (IR) in patients with early RA treated with two different treat-to-target strategies. | 27638812 |
| SLC25A20 gene | Deregulated Nutrient Sensing | Waist circumference and insulin resistance were greatest in PE women with CAC. | 27639028 |
| Dyslipidemias, Myocardial Infarction, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidaemia is the key risk factor for arthrosclerosis, leading to myocardial infarctions and strokes. | 27641514 |
| Neuralgia | Deregulated Nutrient Sensing | As compared to healthy volunteers, neuropathic pain patients exhibited an increased expression of miR-124a (2.5 +- 0.7, p < 0.05) and miR-155 (1.3 +- 0.3; p < 0.05) as well as a reduced expression of SIRT1 (0.5 +- 0.2; p < 0.01). | 27646435 |
| Inflammation, Neuralgia | Deregulated Nutrient Sensing | Our findings suggest that in neuropathic pain, enhanced targeting of SIRT1 by miR-124a and miR-155 induces a bias of CD4(+) T cell differentiation towards Tregs, thereby limiting pain-evoking inflammation. | 27646435 |
| Muscle, Smooth, Vascular | Deregulated Nutrient Sensing | SIRT1 in vascular smooth muscle cells was remarkably downregulated in the suprarenal aortas of aged mice, in which AAAs induced by angiotensin II infusion were significantly elevated. | 27650558 |
| vascular inflammations | Deregulated Nutrient Sensing | Mechanistically, the reduction of SIRT1 was shown to increase vascular cell senescence and upregulate p21 expression, as well as enhance vascular inflammation. | 27650558 |
| Inflammation, Glucocorticoid deficiency with achalasia, Muscle, Smooth, Vascular | Deregulated Nutrient Sensing | These findings provide evidence that SIRT1 reduction links vascular senescence and inflammation to AAAs and that SIRT1 in vascular smooth muscle cells provides a therapeutic target for the prevention of AAA formation. | 27650558 |
| Inflammation, Aortic Aneurysm, Abdominal | Deregulated Nutrient Sensing | Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm. | 27650558 |
| Psoriasis | Deregulated Nutrient Sensing | The role of irisin in the relationship between psoriasis and insulin resistance. | 27652568 |
| Psoriasis | Deregulated Nutrient Sensing | We aimed to elucidate the pathogenesis of insulin resistance in psoriasis patients by evaluating serum irisin levels and metabolic parameters associated with insulin resistance in patients with plaque-type psoriasis vulgaris. | 27652568 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Insulin-Like Growth Factor 1/Mammalian Target of Rapamycin and AMP-Activated Protein Kinase Signaling Involved in the Effects of Metformin in the Human Endometrial Cancer. | 27654259 |
| Ketosis, Hyperglycemic Hyperosmolar Nonketotic Coma, Diabetes Mellitus | Deregulated Nutrient Sensing | Type 2 and ketosis prone diabetes in the non-ketotic phase were comparable in terms of lipid profile, blood pressure, waist-to-hip ratio, BMI and fat mass, insulin secretion and insulin resistance indices. | 27657549 |
| Tuberculosis, Noncommunicable Diseases, Dyslipidemias, HIV, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | They may present some Non-communicable diseases (NCD), such as hypertension, diabetes mellitus, dyslipidemia and/or obesity and, predominantly present a great chance of being a carrier of the Human Immunodeficiency Virus, associated or not with tuberculosis. | 27659611 |
| Dyslipidemias | Deregulated Nutrient Sensing | A Common Gene Variant in Glucokinase Regulatory Protein Interacts With Glucose Metabolism on Diabetic Dyslipidemia: the Combined CODAM and Hoorn Studies. | 27660121 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 Diabetes (T2D) develops, when b-cell insulin response fails to compensate for insulin resistance. | 27664841 |
| Units Of Measure - Siemens | Deregulated Nutrient Sensing | MHO and MONW individuals were identified using fasting glucose, insulin resistance, blood pressure, triglycerides, C-reactive protein, and high-density lipoprotein-cholesterol. | 27665232 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Decreased blood concentration of Glu-OC may be a selective early symptom of insulin resistance in obesity, whereas the decreased level of Gla-OC seems to be associated with the appearance of early markers of low grade inflammation accompanying obesity. | 27667744 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | These findings suggest that glucose intolerance in PA may be caused by hypokalemia-induced insulin resistance and hypokalemia-independent impairment of early-phase insulin secretion. | 27669369 |
| Diastolic hypertension | Deregulated Nutrient Sensing | In addition, BMI increases between 13-17 years and 17-21 years were associated with increases in systolic and diastolic blood pressure, and insulin resistance, but more strongly for the later period. | 27677621 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | It is well known that dyslipidemia is a subclinical manifestation of atherosclerosis. | 27678442 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. | 27680666 |
| Dyslipidemias, Blood Glucose | Deregulated Nutrient Sensing | Our findings in mice and humans suggested that decreased cav-1 expression may activate the effect of aldosterone/MR signaling on several pathways of glycemia, dyslipidemia, and resistin. | 27680666 |
| Tortuosity, Dyslipidemias, Calcinosis | Deregulated Nutrient Sensing | Calcification, age, PBR, dyslipidemia and tortuosity are other independent risk factors for PSR. | 27681252 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | 60% of the patients presented hypertension, 57% dyslipidemia, 21% type 2 diabetes mellitus, 45% smoking, and 34.7% a previous MI. | 27681955 |
| Inflammation | Deregulated Nutrient Sensing | Findings from animal studies have proposed underlying mechanisms including increased activation of the renin-angiotensin system, increased blood pressure, insulin resistance and chronic low-grade inflammation. | 27687738 |
| Liver Dysfunction, Diabetes Mellitus | Deregulated Nutrient Sensing | Incidence of insulin resistance and diabetes in patients with portosystemic shunts without liver dysfunction. | 27688688 |
| SCHISTOSOMIASIS CHRONIC HEPATIC, Diabetes Mellitus | Deregulated Nutrient Sensing | Objective To investigate the incidence of insulin resistance (IR) and diabetes in patients with chronic hepatic schistosomiasis japonica (HSJ) and portosystemic shunts (PSS). | 27688688 |
| Peripheral Vascular Diseases, Alopecia, Alopecia, CTCAE, square decimeter | Deregulated Nutrient Sensing | This hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2. | 27692164 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Here, we investigated how acetyl-CoA carboxylase (ACC), a downstream target of AMPK, rewires cancer metabolism in response to cetuximab treatment. | 27693630 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | We found that introduction of experimental ACC mutants lacking the AMPK phosphorylation sites (ACC1_S79A and ACC2_S212A) into head and neck squamous cell carcinoma (HNSCC) cells protected HNSCC cells from cetuximab-induced growth inhibition. | 27693630 |
| ACACA wt Allele | Deregulated Nutrient Sensing | HNSCC cells with acquired cetuximab resistance contained not only high levels of T172-phosphorylated AMPK and S79-phosphorylated ACC1 but also an increased level of total ACC. | 27693630 |
| ACACA wt Allele, Primary malignant neoplasm | Deregulated Nutrient Sensing | Our data suggest a novel paradigm in which cetuximab-mediated activation of AMPK and subsequent phosphorylation and inhibition of ACC is followed by a compensatory increase in total ACC, which rewires cancer metabolism from glycolysis-dependent to lipogenesis-dependent. | 27693630 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Dyslipidemia is often detected in patients with chronic kidney disease (CKD). | 27695128 |
| Sleeplessness, Sleep Apnea, Obstructive, Hypertension, CTCAE | Deregulated Nutrient Sensing | An apnea- and hypoxia-independent effect of sleep fragmentation on sympathetic discharge during wakefulness could contribute to intersubject variability, age-related increases in muscle sympathetic nerve activity, associations between sleep deprivation and insulin resistance or insomnia and future cardiovascular events, and residual adrenergic risk with persistence of hypertension should therapy eliminate obstructive apneas but not arousals. | 27698070 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | In addition, JAMRISC was useful not only as a MetS risk score test, but also as a screening tool for diagnosing insulin resistance. | 27699688 |
| Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt Allele | Deregulated Nutrient Sensing | JAMRISC questionnaire is a useful instrument for the detection of early risk of not only MetS and type 2 diabetes but also insulin resistance. | 27699688 |
| Obesity | Deregulated Nutrient Sensing | lower insulin resistance, lower C-reactive protein, lower degree of obesity and visceral fat rating (p < .05), despite the higher fat percentage (p < .05). | 27700189 |
| Dyslipidemias, Alcoholic Intoxication, Chronic | Deregulated Nutrient Sensing | smokers 59, 7%, alcoholism 19.5%, DM 10.9%, AHT: 53.6%, dyslipidemia 30.5%. | 27702437 |
| TG gene, diabetic | Deregulated Nutrient Sensing | This observational retrospective study investigated whether diabetic dyslipidemia-that is, high triglyceride (TG) and/or low HDL cholesterol (HDL-C) levels-contributes to this high residual risk for DKD. | 27703024 |
| cardiac muscle tissue growth | Deregulated Nutrient Sensing | Here, we show that simultaneous inhibition of mTOR signaling to both S6K1 and 4E-BP1 is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin. | 27705797 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus. | 27709225 |
| Hyperglycemia | Deregulated Nutrient Sensing | Furthermore, we investigated the effects of the a-glucosidase inhibitor acarbose and the PPARg agonist rosiglitazone, targeting hyperglycaemia or insulin resistance, versus placebo, in 28 and 18 T2DM subjects, respectively. | 27709225 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | In conclusion, resistin, antagonising insulin action in part through PPARg activation, may favour insulin resistance and enhance oxidative stress, endothelial dysfunction and platelet activation. | 27709225 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | The available literature suggests that circulating visfatin/Nicotinamide Phosphoribosyltransferase (NAMPT) level variability in humans is related to obesity, insulin resistance, inflammation, and lipid profile. | 27712122 |
| Hyperlipidemia, Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | One thousand adults with one or more qualifying changes in statin therapy and one or more previous diagnoses of hyperlipidemia, hypercholesterolemia, or mixed dyslipidemia were identified from the Henry Ford Health System administrative database. | 27712714 |
| Dyslipidemias | Deregulated Nutrient Sensing | We aimed to elucidate their associations with current dyslipidemias, and identify their levels at increased risk to dyslipidemia. | 27713142 |
| Dyslipidemias | Deregulated Nutrient Sensing | The substantial discordances with current dyslipidemias might provide novel view in lipid management and further cardiovascular benefit. | 27713142 |
| Prediabetes syndrome, Blood Glucose | Deregulated Nutrient Sensing | These findings support that consumption of IEB in prediabetic subjects produces a response that is dependent on BMI, with a clear improvement of insulin resistance and postprandial and nocturnal glycemia in non-obese subjects and a marked anti-inflammatory response in obese subjects. | 27713964 |
| Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction. | 27714551 |
| Hypoperfusion | Deregulated Nutrient Sensing | Correlation analyses revealed that in patients, hypoperfusion in PCC and precuneus regions were related to higher insulin resistance level and deficits in clock-drawing performance, while the occipital hypoperfusion was associated with worse visual-memory performance, regardless of PVEs correction. | 27714551 |
| Presenile dementia, Iris hypoperfusion | Deregulated Nutrient Sensing | The cerebral hypoperfusion pattern in T2DM resembles the pattern observed in the early stage of dementia, and increased insulin resistance might be an important risk factor as well as treatment target for such CBF dysregulation. | 27714551 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women. | 27716220 |
| Dyslipidemias, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Our data indicate that the rs662799 polymorphism is associated with dyslipidemia and the severity of CHD in Chinese women. | 27716220 |
| MVK gene, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population. | 27716295 |
| Sarcopenia | Deregulated Nutrient Sensing | The non-obese sarcopenia subgroup showed health problems related to insulin resistance and metabolic-related factors compared with the nonsarcopenic group. | 27717662 |
| TG gene | Deregulated Nutrient Sensing | Significant reduction in fasting plasma glucose (FPG), insulin, insulin resistance (by HOMA-IR) and TG concentrations and an increase in HDL.C was seen over the 12 wk of study in each group (p < 0.001). | 27720403 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR), a risk factor for cardiovascular disease and all-cause mortality, is prevalent among maintenance hemodialysis patients. | 27721230 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Compounds in cocoa and chocolate have established cardiovascular benefits, including beneficial effects on insulin resistance, a risk factor for type 2 diabetes mellitus. | 27725277 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Homeostatic model assessment for insulin resistance was associated with increased E/E' (P<0.001), and greater relative wall thickness and septal thickness (both P<0.05); lower stroke volume (P<0.0001); and lower peak lateral and septal E' velocities (both P<0.01). | 27729362 |
| Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | Glucose intolerance and insulin resistance are associated with unfavorable cardiac structure and function, particularly worsened measures of diastolic function, even before the development of diabetes mellitus. | 27729362 |
| Glucose Intolerance (disease), Cerebrovascular accident | Deregulated Nutrient Sensing | Glucose intolerance was associated with increased left ventricular posterior wall and interventricular septal and relative wall thicknesses (all P<0.05), reduced ejection fraction (P<0.01), reduced stroke and end-diastolic volumes (both P<0.001), decreased peak E' velocity (lateral and septal P<0.001), and increased E/E' ratio (lateral and septal P<0.01). | 27729362 |
| Colon Carcinoma | Deregulated Nutrient Sensing | We aimed to determine mTOR activity-related proteins in clinically followed, conventionally treated colon carcinomas and to analyse the correlation between clinical data and mTORC1 and mTORC2 activity. | 27729429 |
| Neoplasms | Deregulated Nutrient Sensing | The presented staining panel could be appropriate and highly recommended for the accurate specification of mTORC1 and C2 activity of tumour tissues. | 27729429 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increased urinary excretion of Cr was reported in subjects with diabetes compared with non-diabetic controls and those with non-diabetic insulin resistance. | 27731332 |
| Dyslipidemias, Cerebral Atherosclerosis, diabetic | Deregulated Nutrient Sensing | Dyslipidemia occurring in diabetic patients, play a critical role in acceleration of macrovascular atherosclerosis and contribute to the excess risk of CVD. | 27731552 |
| Prediabetes syndrome, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | These prediabetic individuals, because of their dyslipidemia, are at higher risk for developing cardiovascular disease. | 27731552 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | To determine the associations of SHBG, T, and DHT with insulin resistance and incident diabetes in older adult men. | 27732332 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Among older men, higher levels of DHT were inversely associated with insulin resistance and risk of diabetes over the ensuing 10 years, whereas levels of T were not. | 27732332 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increased consumption of high-fat diets is associated with the development of insulin resistance and type 2 diabetes. | 27733250 |
| Weight decreased, diabetic | Deregulated Nutrient Sensing | Inclusion of WWCrB in the daily dietary pattern of diabetic patients resulted in improvement of glucose tolerance and insulin resistance, significant reduction in HbA1c, weight loss and lower SBP. | 27734127 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). | 27736893 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | CAD patients were older and more likely to have diabetes, hypertension, dyslipidemia and chronic kidney disease. | 27737597 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging. | 27737951 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Whether individuals with insulin resistance (IR) but without criteria for diabetes exhibit reduced mitochondrial oxidative capacity is unclear; addressing this question could guide research for new therapeutics. | 27737951 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by activation of AMPK/mTOR inhibition. | 27745917 |
| Neoplasms | Deregulated Nutrient Sensing | Tumor samples were evaluated for changes in AMPK, PI3K/AKT pathway, proliferation, and apoptosis by immunohistochemistry. | 27745917 |
| Degenerative polyarthritis, Hyperlipidemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Other common comorbidities were hypertension (37.6%), osteoarthritis (31.4%), and hyperlipidaemia/dyslipidaemia (30.3%). | 27749234 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice. | 27752896 |
| Cartilage destruction, Degenerative polyarthritis | Deregulated Nutrient Sensing | The results showed clear knee joint cartilage destruction and degeneration in the SIRT1-/- osteoarthritis group. | 27752896 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Compared with the SIRT1+/+ osteoarthritis group and SIRT1-/- control group, SIRT1 protein expression was not obviously changed in the SIRT1-/- osteoarthritis group (P>0.05), while the expression levels of the SREBP2, VEGF and HMGCR proteins were significantly increased (P<0.05) and the levels of AKT and type II collagen proteins were significantly decreased (P<0.05). | 27752896 |
| Degenerative polyarthritis, Degenerative disorder of cartilage | Deregulated Nutrient Sensing | SIRT1 gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT signalling pathway, suggesting that SIRT1 gene may play a protective role against osteoarthritis. | 27752896 |
| Dyslipidemias, Chronic Lymphocytic Leukemia | Deregulated Nutrient Sensing | The Association of Dyslipidemia With Chronic Lymphocytic Leukemia: A Population-Based Study. | 27754925 |
| Dyslipidemias, Chronic Lymphocytic Leukemia | Deregulated Nutrient Sensing | We demonstrate a higher prevalence of dyslipidemia preceding a diagnosis of CLL compared with control subjects, supporting preclinical data. | 27754925 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A retrospective cross-sectional cohort analysis of 51,879 elderly Medicare fee-for-service beneficiaries with diabetes and 129,762 beneficiaries with dyslipidemia living in 10 east coast states. | 27755393 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | These lipoprotein subfraction parameters had stronger associations with insulin resistance compared to conventional lipid profiles in the IFG and T2D groups. | 27756036 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is initiated in an early stage of impaired glucose metabolism, when early intervention might be required. | 27756036 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Statin therapy is associated with a slightly increased risk of developing diabetes mellitus and insulin resistance in patients without diabetes. | 27756478 |
| Inflammation, Steatohepatitis | Deregulated Nutrient Sensing | MES + HS treatment (when all three groups were combined), significantly improved visceral adiposity, glycemic control, insulin resistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to baseline. | 27759092 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes and dyslipidaemia were the major comorbidities reported in patients with uncontrolled and resistant hypertension. | 27759337 |
| Hypertension, CTCAE, Myocardial Ischemia, Dyslipidemias, Comorbidity | Deregulated Nutrient Sensing | Hypertension (80.8%) was the most common comorbidity, and dyslipidemia (59.0%) and ischemic heart disease (21.3%) were also prevalent. | 27759630 |
| Tumor necrosis, Rheumatoid Arthritis | Deregulated Nutrient Sensing | 1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes. | 27763638 |
| Diabetes Mellitus, Non-Insulin-Dependent, Necrosis with inflammation | Deregulated Nutrient Sensing | In a prospective study of patients with type 2 diabetes, we found diets high in protein (either animal or plant) significantly reduced liver fat independently of body weight, and reduced markers of insulin resistance and hepatic necroinflammation. | 27765690 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity, and insulin resistance. | 27765765 |
| Hypertension, CTCAE, Demographics Domain, Dyslipidemias | Deregulated Nutrient Sensing | Significant association was found between CAD and risk factors like hypertension, DM, dyslipidemia, smoking, tobacco consumption, WHR and BMI. | 27766800 |
| Lecithin Acyltransferase Deficiency, Dyslipidemias | Deregulated Nutrient Sensing | The diagnosis of familial LCAT deficiency was confirmed by clinical examination, characteristic dyslipidemia, undetectable LCAT levels in plasma and positive family history. | 27766813 |
| ARCN1 gene, Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | Sirtuin-1 (SIRT1) and SIRT6, NAD+-dependent Class III protein deacetylases, are putative anti-aging enzymes, down-regulated in patients with chronic obstructive pulmonary disease (COPD), which is characterized by the accelerated ageing of the lung and associated with increased oxidative stress. | 27767101 |
| ARCN1 gene, Simultaneous | Deregulated Nutrient Sensing | Here, we show that oxidative stress (hydrogen peroxide) selectively elevates microRNA-34a (miR-34a) but not the related miR-34b/c, with concomitant reduction of SIRT1/-6 in bronchial epithelial cells (BEAS2B), which was also observed in peripheral lung samples from patients with COPD. | 27767101 |
| ARCN1 gene | Deregulated Nutrient Sensing | Importantly, miR-34a antagomirs increased SIRT1/-6 mRNA levels, whilst decreasing markers of cellular senescence in airway epithelial cells from COPD patients, suggesting that this process is reversible. | 27767101 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. | 27768686 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Diagnostic investigation of BIRC6 and SIRT1 protein expression level as potential prognostic biomarkers in patients with non-small cell lung cancer. | 27768839 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Therefore, the present study was designed to evaluate the prognostic and diagnostic value of SIRT1/BIRC6 expression in non-small cell lung cancer (NSCLC). | 27768839 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | The data on the prognostic impact of SIRT1/BIRC6 in NSCLC were collected from September 11, 2006 to July 10, 2014. | 27768839 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | MRNA level of SIRT1 was upregulated in NSCLC tissues as compared to normal tissues (3.18 +- 0.77 vs. 1.27 +- 0.62; P = .001). | 27768839 |
| Non-Small Cell Lung Carcinoma, Neoplasms | Deregulated Nutrient Sensing | SIRT1 and BIRC6 may be linked to tumor progression and could be useful for the treatment of NSCLC. | 27768839 |
| Hyperglycemia, Impaired T cell function, Diabetes Mellitus | Deregulated Nutrient Sensing | Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, b-cell dysfunction and long-term complications of diabetes. | 27769710 |
| GDC Comorbidity Terminology, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hypertension was the most common comorbid condition with 60.8 % of patients followed by obesity and dyslipidaemia. | 27770227 |
| Metabolic acidosis, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Correction of metabolic acidosis improves insulin resistance in chronic kidney disease. | 27770799 |
| Chronic Kidney Diseases, diabetic | Deregulated Nutrient Sensing | However, it is unknown whether these interventions reduce insulin resistance (IR) in diabetic patients with CKD. | 27770799 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | Although dyslipidemia increases the risk for ischemic stroke, previous studies reported conflicting data regarding the association between lipid levels and stroke severity and outcome. | 27771869 |
| Inflammation, Breast Carcinoma | Deregulated Nutrient Sensing | Insulin Resistance and Inflammation in Black Women with and without Breast Cancer: Cause for Concern. | 27773978 |
| Inflammation, Breast Carcinoma, Overweight | Deregulated Nutrient Sensing | We compared insulin resistance, inflammation, and lipids in overweight and obese Black women with a history of breast cancer (n=19), age similar controls (n=25), and older controls (n=32). | 27773978 |
| Inflammation, Breast Carcinoma | Deregulated Nutrient Sensing | These biomarkers of insulin resistance and inflammation may be associated with increased risk of breast cancer recurrence and require ongoing evaluation, especially given the relatively abnormal findings compared with the controls in this underserved group. | 27773978 |
| Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | BRP4 was also found to participate in the occurrence of insulin resistance, which may indicate its role as a potential biomarker which identifies cases of insulin resistance of CHD patients and is worth further study. | 27775783 |
| Progranulins, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). | 27776152 |
| Hypertriglyceridemia | Deregulated Nutrient Sensing | In addition, the MUO group exhibited increased risks of hypertriglyceridemia (OR: 2.57, P = 0.001), insulin resistance (OR: 2.37, P = 0.001) and elevated C-reactive protein level (OR: 2.09, P = 0.003). | 27776717 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Also in morbidly obese the higher leptin level and leptin-to-adiponectin ratio and simultaneously lower concentration of leptin receptor are associated with leptin resistance, additionally in possible future risk of insulin resistance and diabetes type 2. | 27779476 |
| Skeletal muscle structure, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Increases in the amount of inducible nitric oxide synthase (iNOS) protein and abnormal production of nitric oxide (NO) in skeletal muscle have been suggested to be associated with peripheral insulin resistance in patients with type 2 diabetes mellitus (T2DM). | 27782779 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Traditional risk factors for CO such as gender, dyslipidemia, hypertension and diabetes were associated with both measures. | 27783768 |
| Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease. | 27784320 |
| ARCN1 gene | Deregulated Nutrient Sensing | Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients. | 27784320 |
| ARCN1 gene | Deregulated Nutrient Sensing | The expression of CD31, CD34, Sirt1 mRNAs, and miR-126-3p decreased and that of miR-34a increased in moderate COPD compared with that in control smokers. | 27784320 |
| ARCN1 gene | Deregulated Nutrient Sensing | Sirt1 expression in blood cells from patients with COPD could be a biomarker for disease stability in patients with moderate COPD. | 27784320 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Refractory MG patients have higher prevalence and poor control (HbA1C >8%) of diabetes mellitus and dyslipidemia probably due to increased steroid usage. | 27790079 |
| Intervertebral Disc Degeneration | Deregulated Nutrient Sensing | The present study is a continuation and complement of our former in vivo study of Sirt1 and its role in puncture-induced rodent disc degeneration model. | 27792110 |
| Intervertebral disc structure | Deregulated Nutrient Sensing | Sirt1 protein expression level decreased in the discs of high Pfirrmann grade and the score of histological morphology of human intervertebral disc is consistent with the Pfirrmann grade. | 27792110 |
| Intervertebral Disc Degeneration | Deregulated Nutrient Sensing | Sirt1 is a protective mediator in IVD degeneration and the expression of Sirt1 decreases in degenerative disc. | 27792110 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Asthma | Deregulated Nutrient Sensing | The highest concordance was achieved for diabetes and three combined cardiovascular disorders, while it was substantial for dyslipidemia and hyperuricemia, and low for asthma. | 27792735 |
| Papillary thyroid carcinoma | Deregulated Nutrient Sensing | Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma. | 27793057 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Epigenetic modification and dysregulation affecting the HIC1/SIRT1 axis is potentially important for the development of malignancies. | 27793057 |
| Thyroid Neoplasm | Deregulated Nutrient Sensing | Compared to normal thyroid tissue, thyroid tumors had lower expression of HIC1 and higher SIRT1 expression. | 27793057 |
| Negative Regulation of Cell Cycle | Deregulated Nutrient Sensing | Restoration of HIC1 expression through an overexpression plasmid or 5-aza-dC treatment reduced SIRT1 expression and cell proliferation, and led to senescence, cell cycle arrest, and apoptosis. | 27793057 |
| Papillary thyroid carcinoma | Deregulated Nutrient Sensing | Aberrant expression of HIC1/SIRT1 and hypermethylation of the HIC1 promoter may be critical for the development and progression of papillary thyroid cancer. | 27793057 |
| Increased insulin level, Metabolic Diseases | Deregulated Nutrient Sensing | Hyperinsulinemia is a hallmark of insulin resistance-associated metabolic disorders. | 27796268 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Cardiovascular Diseases | Deregulated Nutrient Sensing | Postprandial hyperinsulinemia, hyperglycemia, and insulin resistance increase the risk of type 2 diabetes (T2D) and cardiovascular disease mortality. | 27798656 |
| Obesity | Deregulated Nutrient Sensing | Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women. | 27801986 |
| Obesity | Deregulated Nutrient Sensing | The prevalence of obesity has markedly increased and is closely related to insulin resistance. | 27801986 |
| Complication Aspects, Prostate Cancer Outcomes Study, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | In addition, associations of several metabolic complications like insulin resistance, obesity, dyslipidemia and psychological co-morbidities are well known in PCOS. | 27802175 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | One patient had diabetes, three had hypertension, 11 (55%) had dyslipidaemia and 16 (80%) were smokers. | 27805237 |
| Multimorbidity, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, diabetes and dyslipidaemia constituted the most prevalent multimorbidity pattern. | 27809772 |
| Depression, CTCAE | Deregulated Nutrient Sensing | The association between insulin resistance and depression in the Korean general population. | 27810270 |
| Depression, CTCAE | Deregulated Nutrient Sensing | Previous studies showed that the insulin resistance (IR) could be related to depression. | 27810270 |
| Obesity | Deregulated Nutrient Sensing | Recent studies have reported that zinc has been implicated in altered lipid markers, insulin resistance and some obesity markers. | 27814737 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are important cardiovascular risk factors. | 27819152 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | In this retrospective, multicenter study, we collected case report forms (CRFs) of hypertensive patients with concomitant dyslipidemia who were prescribed an ARB/statin regimen between 1 April 2014 and 31 March 2015 from 51 outpatient clinics. | 27819152 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | We identified a strong correlation between medication adherence and BP or LDL-C target achievement in Korean patients with concomitant hypertension and dyslipidemia. | 27819152 |
| Abnormal circulating valine concentration, Hyperinsulinism | Deregulated Nutrient Sensing | Hyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children. | 27824069 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Insulin resistance and intestinal barrier function should be intensively controlled to prevent progression from NAFL to NASH. | 27826704 |
| Infarction | Deregulated Nutrient Sensing | Insulin Resistance Is a Risk Factor for Silent Lacunar Infarction. | 27827330 |
| Infarction, SHC2 gene | Deregulated Nutrient Sensing | This study aims to investigate the association between insulin resistance (IR) and silent lacunar infarction (SLI) in healthy adults. | 27827330 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Associations of daily sleep duration and dietary macronutrient consumption with obesity and dyslipidemia in Koreans: A cross-sectional study. | 27828860 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Daily sleep duration is known to be associated with obesity and dyslipidemia.This study was performed to examine the interactions between daily sleep duration and the risks of obesity and dyslipidemia according to dietary macronutrient consumption in 14,680 Korean adults using the 5th Korean National Health and Nutrition Examination Survey.Sleep duration was inversely associated with body mass index (P < 0.001), waist circumference (P < 0.001), total cholesterol (P < 0.001), and low-density lipoprotein -cholesterol (P = 0.001). | 27828860 |
| Obesity | Deregulated Nutrient Sensing | High fat and low carbohydrate consumption were confirmed to be associated with the risk of obesity in the shortest sleep duration group (<=5 hours a day).These findings indicate that sleep duration was negatively associated with obesity and dyslipidemia-related indices in Korean adults. | 27828860 |
| Hyperglycemia, Dyslipidemias, Overweight, Hypertension, CTCAE | Deregulated Nutrient Sensing | CFA of MS showed that overweight, hyperglycemia, dyslipidemia, and hypertension clustered together under a single latent factor of MS. | 27831641 |
| Tuberous Sclerosis | Deregulated Nutrient Sensing | Inhibitors of mammalian target of rapamycin complex 1, such as sirolimus, effectively target skin lesions in tuberous sclerosis complex (TSC). | 27837201 |
| Inflammation, Dental Plaque, Atherosclerosis | Deregulated Nutrient Sensing | The architectural transcription factor high-mobility-group AT-hook 1 (HMGA1) has been involved in atherosclerosis, plaque formation, inflammation, and in the pathogenesis of insulin resistance and T2DM. | 27839822 |
| Dyslipidemias | Deregulated Nutrient Sensing | In addition to clinical and economical consequences, dyslipidemia may have a significant impact on patients' QOL. | 27842211 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | The increasing frequency of cardiovascular disease (CVD) rests on the presence of major cardiovascular risk factors including dyslipidemia. | 27853034 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | This dyslipidemia is also a target for the prevention and treatment of many cardiovascular diseases. | 27853034 |
| Dyslipidemias, Diabetic Neuropathies, Cerebrovascular accident, Coronary Artery Disease, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Adjustment was made for age, body mass index, waist, duration of type 2 diabetes, current smoking, current drinking, hypertension, dyslipidemia, coronary artery disease, stroke, glycated hemoglobin and diabetic neuropathy. | 27853168 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Selenium exposure can induce liver insulin resistance and increased liver triglyceride concentrations in animals, which may link to an increased risk of nonalcoholic fatty liver disease (NAFLD). | 27853246 |
| Lipolysis | Deregulated Nutrient Sensing | Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance. | 27858284 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | CNR1 is upregulated in states of type 2 diabetes and insulin resistance. | 27858284 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Peripheral CNR1 could be an interesting drug target in type 2 diabetes and dyslipidemia. | 27858284 |
| Primary malignant neoplasm, Atherosclerosis, Heart valve disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Cathepsin S (CS) was shown to play a key role in cancer progression, atherosclerosis, heart valve disease, insulin resistance and diabetes mellitus. | 27858577 |
| Dyslipidemias, Congestive heart failure | Deregulated Nutrient Sensing | Patients with HbA1c >=6.5% were older (70 [63-79] vs 66 [56-75], P < .001) and had a higher incidence of dyslipidemia (83.5% vs 57.0%, P < .001) and congestive heart failure (39.5% vs 27.8%, P = .01). | 27861432 |
| Bone Diseases, Dyslipidemias, Chronic Kidney Diseases, Atherosclerosis | Deregulated Nutrient Sensing | Atherosclerosis is often a complication of chronic kidney disease (CKD) because of dyslipidemia and CKD-mineral and bone disorder. | 27861640 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis, Diabetes Mellitus | Deregulated Nutrient Sensing | To investigate, in the Carotid Atherosclerosis: Metformin for Insulin Resistance (CAMERA) trial (NCT00723307), whether the influence of metformin on the glucagon-like peptide (GLP)-1 axis in individuals with and without type 2 diabetes (T2DM) is sustained and related to changes in glycaemia or weight, and to investigate basal and post-meal GLP-1 levels in patients with T2DM in the cross-sectional Diabetes Research on Patient Stratification (DIRECT) study. | 27862873 |
| Steatohepatitis, Hypertriglyceridemia, Diabetes Mellitus, Lipodystrophy, Lipolysis | Deregulated Nutrient Sensing | The homozygous null LIPE mutation could result in marked inhibition of lipolysis from some adipose tissue depots and thus may induce an extremely rare phenotype of MSL and partial lipodystrophy in adulthood associated with complications of insulin resistance, such as diabetes, hypertriglyceridemia and hepatic steatosis. | 27862896 |
| Small cell carcinoma of lung | Deregulated Nutrient Sensing | Taken together, our results suggest that SCLC patients with RICTOR amplification may constitute a clinically important subgroup because of their potential response to mTORC1/2 inhibitors. | 27863413 |
| Osteoarthritis, Knee | Deregulated Nutrient Sensing | The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity. | 27863529 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | The expression of SIRT1 in articular cartilage is negatively associated with severity of knee OA, indicating that SIRT1 may act as a monitoring indicator for determining development and progression of knee OA. | 27863529 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | We previously reported the association between toothbrushing practices and diabetes mellitus (DM) and dyslipidemia (DL) in a cross-sectional study. | 27863909 |
| Retinal Vein Occlusion, Dyslipidemias | Deregulated Nutrient Sensing | Retinal oximetry during treatment of retinal vein occlusion by ranibizumab in patients with high blood pressure and dyslipidemia. | 27865689 |
| Hypertensive disease, Dyslipidemias, Edema | Deregulated Nutrient Sensing | We retrospectively reviewed the medical records of six patients with visual acuity (VA) reduced by macular edema (ME) secondary to RVO with HBP and dyslipidemia, who underwent intravitreal anti-VEGF injection between October 2014 and February 2015 in the department of ophthalmology of Francois-Quesnay Hospital at Mantes-la-Jolie (France). | 27865689 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | In this study, retinal venous oxygen saturation in patients with RVO, HBP and dyslipidemia was partially normalized during intravitreal ranibizumab treatment. | 27865689 |
| Blood Glucose | Deregulated Nutrient Sensing | A significant reduction in blood glucose, insulin resistance, lipid profile, and anthropometric parameters was observed. | 27865810 |
| Dental Plaque | Deregulated Nutrient Sensing | Insulin resistance and circulating concentrations of TNF-a, IL-6, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A and urinary microalbumin decreased after empagliflozin treatment, and this significantly correlated with plaque size. | 27866224 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Improvements in inflammation and insulin resistance seem to be mechanisms involved in the mitigation of atherosclerosis by empagliflozin. | 27866224 |
| Primary gout | Deregulated Nutrient Sensing | Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout. | 27878622 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | The aim of the present study was to examine the association between peripheral differential leukocyte counts and dyslipidemia in a Chinese hypertensive population. | 27879312 |
| Dyslipidemias | Deregulated Nutrient Sensing | In summary, these findings indicate that elevated differential leukocyte counts are directly associated with serum lipid levels and increased odds of dyslipidemia. | 27879312 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension (42%) and dyslipidaemia (37%) were the most commonly reported comorbidities; 7% reported on diabetes and 23% of men ( vs. 17% of women) were smokers. | 27879413 |
| Obesity, Abdominal, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Abdominal obesity (measured as waist circumference) was the most common cardiovascular risk factor (61.7%) followed by age (40.5%), dyslipidaemia (36.3%) and diabetes (34.3%). | 27884949 |
| Non-alcoholic Fatty Liver Disease, Overweight | Deregulated Nutrient Sensing | Circulating periostin in relation to insulin resistance and nonalcoholic fatty liver disease among overweight and obese subjects. | 27885258 |
| Non-alcoholic Fatty Liver Disease, Overweight | Deregulated Nutrient Sensing | Elevated circulating periostin level was associated with an increased risk of having NAFLD and insulin resistance among overweight and obese individuals. | 27885258 |
| Obesity | Deregulated Nutrient Sensing | Creatine kinase (CK), the central regulatory enzyme of energy metabolism, is particularly high in type II skeletal muscle fibers, which are associated with insulin resistance and obesity. | 27894867 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We further found that the risk of CAD is greatly potentiated by several concomitant risk factors (smoking, diabetes, hypertension, dyslipidemia, and a family history of CAD). | 27895197 |
| Uremia, Inflammation, Skeletal muscle structure, Cachexia | Deregulated Nutrient Sensing | Inflammation in skeletal muscle is implicated in the pathogenesis of insulin resistance and cachexia but why uremia up-regulates pro-inflammatory cytokines is unknown. | 27897392 |
| Obesity | Deregulated Nutrient Sensing | Lipoprotein lipase (LPL) activity is considered the rate-limiting step of very-low-density-lipoprotein triglycerides (VLDL-TG) tissue storage, and has been suggested to relate to the development of obesity as well as insulin resistance and type 2 diabetes. | 27898284 |
| AHSG protein, human, Atherosclerosis | Deregulated Nutrient Sensing | Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. | 27899247 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Multivariate analysis demonstrated that in patients with T2DM the odds of PAD increased with long diabetes duration, smoking, presence of arterial hypertension and dyslipidemia, as well as with lower fetuin-A levels. | 27899247 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. | 27899364 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Short Adult Stature Predicts Impaired b-Cell Function, Insulin Resistance, Glycemia, and Type 2 Diabetes in Finnish Men. | 27906553 |
| Primary malignant neoplasm, Hypertension, CTCAE, Non-Cancer Related Death, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, fasting glucose and dyslipidemia showed differential impacts on cancer and non-cancer death, and were significantly predictive for non-cancer death. | 27906989 |
| Alzheimers Disease", Impaired cognition, Data types - Address, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are associated with neuropathology and cognitive decline in Alzheimer's disease (AD). | 27911319 |
| Increased insulin level | Deregulated Nutrient Sensing | A 29-year-old woman developed an autoantibody to the insulin receptor (type B insulin resistance), causing extreme insulin resistance and hyperinsulinemia. | 27911591 |
| Obesity, Abdominal, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | Treatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but improves dyslipidemia in type 2 diabetic patients with abdominal obesity: a randomized, double-blind, placebo-controlled trial. | 27913872 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Interaction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men: the Third National Health and Nutrition Examination Survey. | 27914732 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | We examined interaction of sex steroid hormones and obesity with regard to insulin resistance (IR) and type 2 diabetes (T2D) by using nationally representative data from the US. | 27914732 |
| Disease, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The independent variables were age, number of diseases and medications, diagnosis of hypertension, dyslipidemia and diabetes, and tabagism. | 27915426 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | On the other hand, dyslipidemia is recognized as a prominent risk factor for cardiovascular disease. | 27919279 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. | 27919453 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Numerous studies suggest that rapamycin treatment promotes insulin resistance, implying that rapamycin could have negative effects on patients with, or at risk for, type 2 diabetes (T2D). | 27922820 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women. | 27925359 |
| Best Case Imputation Technique | Deregulated Nutrient Sensing | A structured AEI may improve insulin, HOMA-IR index and body composition in non-obese BC survivors without insulin resistance. | 27925359 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance. | 27926472 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients of CAS with CAD showed higher prevalence of diabetes, hypertension, dyslipidemia, smoking and family history of CAD. | 27931555 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Previous studies have shown an inconsistent relation between habitual beverage consumption and insulin resistance and prediabetes. | 27934644 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Regular SSB intake, but not diet soda intake, is associated with a greater increase in insulin resistance and a higher risk of developing prediabetes in a group of middle-aged adults. | 27934644 |
| Cancer-related fatigue, Obesity, Abdominal | Deregulated Nutrient Sensing | Abdominal obesity and low cardiorespiratory fitness (CRF) are associated with insulin resistance in older adults. | 27936206 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, hypertension, dyslipidemia, smoking as well as elevated homocysteine and HsCRP found as risk factors of PAD. | 27938397 |
| Inflammation | Deregulated Nutrient Sensing | Disturbed sleep has been associated with increased insulin resistance and elevated inflammation. | 27938923 |
| Depression, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The regression models showed that in women, higher sleep onset latency (SOL) was associated with higher insulin resistance after controlling for age, smoking, obesity, diabetes, depression, and inflammatory cytokines. | 27938923 |
| Cerebrovascular Disorders, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen | Deregulated Nutrient Sensing | Antiepileptic drugs (AEDs) may increase development of dyslipidemia and cerebrovascular disease (CVD). | 27939141 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | CVD risk profile showed obesity of 18 patients (12%), current smoker of 30 patients (20%), hypertension of 75 patients (50%), diabetes mellitus of 32 patients (21%), dyslipidemia of 15 patients (10%), and atrial fibrillation of 63 patients (42%). | 27939141 |
| Primary malignant neoplasm, Dyslipidemias, Breast Carcinoma | Deregulated Nutrient Sensing | Although dyslipidemia has been documented to be associated with several types of cancer including breast cancer, it remains uncertainty the prognostic value of serum lipid in breast cancer. | 27939967 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The arginine vasopressin (AVP) system has been postulated to play a role in glucose homeostasis, insulin resistance, and diabetes mellitus in human and animal studies. | 27940301 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Decreased circulating BMP-9 levels in patients with Type 2 diabetes is a signature of insulin resistance. | 27940998 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | However, no report has demonstrated the relationship of circulating BMP-9 levels with insulin resistance (IR) or Type 2 diabetes mellitus (T2DM) in humans. | 27940998 |
| Dysphonia, Dyslipidemias, Gait abnormality, Horner Syndrome, Cerebellar Ataxia | Deregulated Nutrient Sensing | Regarding the risk factors, dyslipidemia and smoking predominated in the studied group and the most common signs and symptoms were gait abnormalities, the ataxia of the limbs, dysphonia, and Horner syndrome. | 27974932 |
| Inflammation | Deregulated Nutrient Sensing | Inflammation might link microbial exposures to insulin resistance. | 27978598 |
| Proteobacteria | Deregulated Nutrient Sensing | Proteobacteria levels were associated with insulin resistance (p < 0.05). | 27978598 |
| Inflammation, Proteobacteria, Actinobacteria phylum | Deregulated Nutrient Sensing | Inflammation explained 30-98% of the observed associations between levels of Actinobacteria, Proteobacteria or Firmicutes and insulin resistance (p-values < 0.05). | 27978598 |
| Periodontitis, Prediabetes syndrome, SMYD1 gene | Deregulated Nutrient Sensing | This study suggests associations between pre-diabetes and insulin resistance with BOP and periodontitis. | 27978601 |
| Cholelithiasis, Gaucher Disease | Deregulated Nutrient Sensing | Patients with Gaucher disease type 1 (GD1) show an altered lipid profile and a certain degree of insulin resistance, which might contribute to cholelithiasis (CL) and could possibly be associated with ABCG5/ABCG8 gene variants. | 27981300 |
| CD55 gene, Pathogenesis | Deregulated Nutrient Sensing | Total serum cholesterol (TC) and LDL-C were higher in patients with CL than in those without; no obvious influence of insulin-resistance to lithogenesis was found. | 27981300 |
| Toxic effect | Deregulated Nutrient Sensing | IHTG accumulation is strongly associated with adipose tissue insulin resistance (IR), supporting the current theory of lipotoxicity as a driver of IHTG accumulation. | 27981615 |
| Dyslipidemias, Weight decreased, Hypertension, CTCAE | Deregulated Nutrient Sensing | Univariate analysis found that older age, male gender, having hypertension, dyslipidemia, and insulin-treated type 2 diabetes were all factors associated with sustained weight loss. | 27989521 |
| Units Of Measure - Siemens, Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Hypertension, CTCAE | Deregulated Nutrient Sensing | While some obese children are metabolically healthy (MHO), some have additional health problems, such as hypertension, dyslipidemia, insulin resistance, and hepatosteatosis, which increase mortality and morbidity related to cardiovascular diseases (CVD) during adulthood. | 27992361 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Patients without dyslipidemia, insulin resistance, hepatosteatosis, or hypertension were considered as MHO. | 27992361 |
| GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | Data regarding alterations of insulin resistance (IR) and ACS after prolonged follow-up are limited. | 27992961 |
| Inflammation, HDL Phospholipid Measurement, ETV3 wt Allele | Deregulated Nutrient Sensing | Low HDL-P is independently associated with incident MetS after adjustment for traditional risk factors, lipid parameters, adiposity, inflammation, and markers of insulin resistance. | 27993539 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | Higher than expected cardiovascular mortality in hemodialysis patients, has been attributed to dyslipidemia as well as inflammation. | 27994294 |
| Bone Diseases, Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | In high-flux membrane hemodialysis patients, we observed a significant relationship of b2M with dyslipidemia and mineral bone disorders, but there was no correlation with inflammation. | 27994294 |
| Autophagic Cell Death | Deregulated Nutrient Sensing | Cell viability, SIRT1 enzyme activity, cell cycle regulation, apoptosis, and autophagic cell death were measured. | 27994519 |
| Hypertensive disease, Primary malignant neoplasm | Deregulated Nutrient Sensing | The aberrant glucose metabolism is one of the hallmarks of cancer cells, and as a branch of glucose metabolism, hexosamine biosynthesis pathway (HBP) has been reported to play a critical role in the insulin resistance and progression of cancer. | 27996048 |
| Cardiovascular Diseases, Prostate Cancer Outcomes Study, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Adolescents with polycystic ovary syndrome (PCOS) have atherogenic dyslipidemia and increased cardiovascular disease (CVD) risk, and this is exacerbated in obesity. | 27997268 |
| Mitochondria | Deregulated Nutrient Sensing | Repressed SIRT1/PGC-1a pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration. | 27998274 |
| methyldopa | Deregulated Nutrient Sensing | Furthermore, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), a regulator of mitochondrial biogenesis and function was repressed, and lower expression levels of NAD-dependent deacetylase sirtuin1 (SIRT1) were found in AMD RPE-iPSC-RPE and AMD Skin-iPSC-RPE as compared to normal RPE-iPSC-RPE. | 27998274 |
| methyldopa, Neurodegenerative Disorders | Deregulated Nutrient Sensing | Our studies suggest SIRT1/PGC-1a as underlying pathways contributing to AMD pathophysiology, and open new avenues for development of targeted drugs for treatment of this devastating neurodegenerative disease of the visual system. | 27998274 |
| Obesity | Deregulated Nutrient Sensing | Association of TCF7L2 and GCG Gene Variants with Insulin Secretion, Insulin Resistance, and Obesity in New-onset Diabetes. | 27998387 |
| Aggressive course, Obesity | Deregulated Nutrient Sensing | Obesity and age, key risk factors for aggressive prostate cancer, are associated with insulin resistance. | 27998647 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Epilepsy | Deregulated Nutrient Sensing | People with epilepsy had less hypertension (43.3% vs. 50.4%), less diabetes (15.8% vs. 19.2%), more dyslipidemia (40.2% vs. 34.6%) and lower cardiovascular risk than the general population (P < 0.01). | 28000339 |
| Dyslipidemias, Epilepsy | Deregulated Nutrient Sensing | People with epilepsy had more dyslipidemia, related to EIAEDs, and lower cardiovascular risk but still took more statins than the general population. | 28000339 |
| Cardiovascular Diseases, Diabetic Nephropathy, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Study participants with type 2 diabetes mellitus (T2DM) only should have at least one other risk factor defined as hypertension, dyslipidaemia, smoking, or diabetic nephropathy, and/or they had a history of cardiovascular disease. | 28002198 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | She also had high blood pressure, dyslipidemia, secondary diabetes mellitus. | 28002537 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Mean age was slightly higher (69+-6 vs 64+-12, p>0.2), and male gender tended to be less frequent (63 vs 79%) with DM than with nonDM; all subjects showed dyslipidemia, and almost all had arterial hypertension. | 28002752 |
| Malignant tumor of colon, Adenoma, Fatty Liver | Deregulated Nutrient Sensing | In multivariate analyses adjusting for age, sex, body mass index, smoking habits, alcohol intake, regular exercise, aspirin and analgesics use, family history of colon cancer, education level, fatty liver, high-sensitivity C reactive protein, homeostasis model assessment of insulin resistance, total cholesterol, and triglyceride, an increase in ALT was positively associated with the prevalence of low-risk and high-risk adenoma (P for trend = 0.029 and 0.027, respectively). | 28002874 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest dyslipidemia might play a role in lower urinary tract symptoms progression. | 28004415 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for cardiovascular disease, with elevated low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) recognized as risk factors for acute coronary events. | 28010729 |
| Inflammation, Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Low-grade chronic inflammation emerges as a potent driver of insulin resistance and glucose dysregulation in obesity and associated non-alcoholic fatty liver disease (NAFLD). | 28011892 |
| Weight Gain | Deregulated Nutrient Sensing | In contrast, adipose-specific, but not hepatocyte-specific deletion of Ifnar1 deteriorated metabolic dysregulation induced by a high-fat diet, indicated by increased weight gain, insulin resistance and an impaired glucose tolerance. | 28011892 |
| Data types - Address | Deregulated Nutrient Sensing | Consistently with sirtuin 1 role in controlling acetylation status, we observed a substantial reduction of the acetylation on histone 3 lysine 9, associated with gene transcription in the AD twin. | 28017215 |
| Adenocarcinoma of lung (disorder) | Deregulated Nutrient Sensing | Expression of mTORC1/2-related proteins in primary and brain metastatic lung adenocarcinoma. | 28025080 |
| Sex Characteristics | Deregulated Nutrient Sensing | Sexual dimorphism in interleukin 17A and adipocytokines and their association with insulin resistance among obese adolescents in Yogyakarta, Indonesia. | 28027637 |
| Obesity | Deregulated Nutrient Sensing | Pro-inflammatory cytokines interleukin 17A (IL-17), leptin, and adiponectin have been associated with obesity and insulin resistance. | 28027637 |
| Dyslipidemias | Deregulated Nutrient Sensing | Compared with group G and controls, group M subjects were older and had increased adiposity indices, dyslipidemia, insulin resistance and elevated transaminase levels (all p < 0.05). | 28027788 |
| Dyslipidemias, Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | It has been demonstrated that diabetic dyslipidaemia is the chief bridge between diabetes and incremental risk of cardiovascular disease in patients with diabetes. | 28027866 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The present study indicated that the changes of lipid profile in patients with T2D are characterised by abnormal distributions of lipoprotein subfractions apart from clinically atherogenic dyslipidaemia. | 28027866 |
| Glucose Intolerance (disease), Pancreatic carcinoma, diabetic | Deregulated Nutrient Sensing | We conclude that GIP and PP plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. | 28027898 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition. | 28028034 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The transcriptional regulator peroxisome proliferator-activated receptor g coactivator 1a (PGC1a) coordinates the exercise-stimulated skeletal muscle fiber-type switch from glycolytic fast-twitch (type IIb) to oxidative slow-twitch (type I) and intermediate (type IIa) fibers, an effect reversed in insulin resistance and diabetes. | 28028076 |
| Endometrial Hyperplasia, Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Prospective evaluation of abnormal glucose metabolism and insulin resistance in patients with atypical endometrial hyperplasia and endometrial cancer. | 28028620 |
| Metabolic Diseases, Non-alcoholic Fatty Liver Disease, Sarcopenia, Obesity | Deregulated Nutrient Sensing | Sarcopenia recognises insulin resistance and obesity as risk factors, and is frequently associated with cardiometabolic disorders, including non-alcoholic fatty liver disease (NAFLD). | 28028821 |
| Periodontitis, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Central adiposity, dyslipidaemia and hypertension were not associated with periodontitis. | 28028834 |
| Atherosclerosis | Deregulated Nutrient Sensing | Sirtuin 1 (Sirt1) plays an important role in vascular biology, and influences aspects of age-dependent atherosclerosis. | 28029409 |
| Apolipoproteins B | Deregulated Nutrient Sensing | Laboratory data analyzed were triglycerides, total cholesterol, HDL, VLDL, LDL, apolipoprotein A1, apolipoprotein B, lipoprotein (a), non-esterified fatty acids (NEFA), glucose, insulin, oxidative stress, C-reactive protein, and Sirt1. | 28029409 |
| Overweight | Deregulated Nutrient Sensing | Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial. | 28029409 |
| Amyotrophic Lateral Sclerosis, Dyslipidemias | Deregulated Nutrient Sensing | The percentage of individuals who had never smoked was greater for the ALS cohort (55.8%, P <= 0.001), and the prevalence of dyslipidemia was lower (38.7%) compared with the general population (74.4%, P < 0.001). | 28029705 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The majority of the patients were male with a medical history of hypertension, dyslipidaemia and previous coronary interventions. | 28031245 |
| Damage | Deregulated Nutrient Sensing | Younger male patients with insulin resistance or organ damage have a higher risk of presenting with FLI-NAFLD at baseline, developing FLI-NAFLD within 3 years, and a lower probability of regression. | 28032449 |
| deficiency aspects | Deregulated Nutrient Sensing | MetS+/DM+ patients have the lowest levels of MEEi, consistent with the alterations of energy supply associated with the combination of insulin resistance with insulin deficiency. | 28032631 |
| Prostate Cancer Outcomes Study, Irregular Menstruation, Hirsutism, Endocrine System Diseases, Hyperandrogenism, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. | 28034591 |
| Alzheimers Disease", Toxic effect | Deregulated Nutrient Sensing | mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-b Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons. | 28035937 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Mammalian target of rapamycin complex 1 (mTORC1), a nutrient sensor and central controller of cell growth and proliferation, is altered in various models of Alzheimer's disease (AD). | 28035937 |
| Data types - Address | Deregulated Nutrient Sensing | In two rodent AD models, mTORC1 and C2 activities were also decreased. | 28035937 |
| Data types - Address | Deregulated Nutrient Sensing | In a neuronal culture model of AD characterized by accumulation of cellular amyloid-b (Ab)42, mTORC1 activity was reduced. | 28035937 |
| Data types - Address | Deregulated Nutrient Sensing | We conclude that striking a new balance by restoring mTORC2 abundance and/or inhibition of mTORC1 has therapeutic potential in AD. | 28035937 |
| Data types - Address | Deregulated Nutrient Sensing | Even less studied or understood in AD is mammalian target of rapamycin complex 2 (mTORC2) that influences cellular metabolism, in part through the regulations of Akt/PKB and SGK. | 28035937 |
| Inflammation, Precocious atherosclerosis, Dyslipidemias, Sample Size Calculation, Obesity | Deregulated Nutrient Sensing | Our findings confirm the presence of premature atherosclerosis in SSc patients assessed by significant impairment of FMD, flow change and ccIMT, and it is associated with traditional cardiovascular risk factors such as age, dyslipidemia and obesity (BMI) as well as with the use of steroids and markers of inflammation such as CRP and ESR. | 28036158 |
| Dyslipidemias | Deregulated Nutrient Sensing | Presence of CAD significantly correlated with dyslipidemia (p=0.047), history of smoking (p=0.025), and family history of CAD (p=0.002). | 28038720 |
| Dyslipidemias, Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus | Deregulated Nutrient Sensing | In the last two decades, studies have suggested that low testosterone levels are associated with increased prevalence of risk factors for cardiovascular disease (CVD), including dyslipidemia and diabetes. | 28038719 |
| Glucose Intolerance (disease), Hypertriglyceridemia | Deregulated Nutrient Sensing | Compared with a random sample of matched population controls, HCT survivors had an increased prevalence of hypertriglyceridemia and low HDL, but not of glucose intolerance, elevated blood pressure, or CVRF cluster. | 28040534 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Sirtuin 1 (SIRT1) appears to play a protective role against endothelial dysfunction and oxidative stress. | 28043667 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | SIRT1 levels correlated marginally with a history of hypertension (r=0.2, p=0.084) and inversely with baseline urea (r=0.25, p=0.056). | 28043667 |
| square decimeter, Diabetes Mellitus | Deregulated Nutrient Sensing | When performing additional adjustment, low SIRT1 levels were independently associated with diabetes mellitus 2(DM2) and subjects with SIRT1 <2.95ng/mL were more prone to present DM2 (82% sensitivity and 62% specificity). | 28043667 |
| Atrial Fibrillation, Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | The index of low SIRT1 and high MMP2 respectively correlated with patients history of MI (r=0.3, p=0.01) and marginally with presence or history of atrial fibrillation (AF) (r=0.213, p=0.076). | 28043667 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | The combined index of low SIRT1 and high MMP2 exhibited a significant correlation with history of MI and EF, promoting a potential prognostic tool for MI incidence in patients regardless their coronary artery disease status. | 28043667 |
| Electrocardiogram: myocardial infarction (finding), Coronary Artery Disease | Deregulated Nutrient Sensing | A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease. | 28043667 |
| Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | Associations among Insulin Resistance, Triacylglycerol/High Density Lipoprotein (TAG/HDL ratio) and Thyroid hormone levels-A study on Type 2 diabetes mellitus in obese and overweight subjects. | 28043815 |
| Comorbidity | Deregulated Nutrient Sensing | In addition to insulin resistance, results of our study were focussed on thyroid comorbidity. | 28043815 |
| Overweight | Deregulated Nutrient Sensing | In overweight diabetic patients, the ROC curve analyses demonstrated that the best marker for insulin resistance was Triacylglycerol/High density lipoprotein (TAG/HDL), with the area under the ROC curve being 0.902. | 28043815 |
| Diabetes Mellitus, Non-Insulin-Dependent, Overweight | Deregulated Nutrient Sensing | In overweight type 2 diabetics, TAG/HDL ratio could be used as a reliable marker for insulin resistance with thyroid co-morbidity and T3, T4 were better objective markers in obese type 2 diabetics. | 28043815 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Disruption of mechanistic target of rapamycin complex 1 (mTORC1) promotes chondrocyte autophagy and survival, and decreases the severity of experimental OA. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | However, the role of cartilage mTORC1 activation in OA initiation is unknown. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | In this study, we elucidated the specific role of mTORC1 activation in OA initiation, and identify the underlying mechanisms. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Expression of mTORC1 in articular cartilage of OA patients and OA mice was assessed by immunostaining. | 28043938 |
| Tuberous Sclerosis | Deregulated Nutrient Sensing | Cartilage-specific tuberous sclerosis complex 1 (Tsc1, mTORC1 upstream inhibitor) knockout (TSC1CKO) and inducible Tsc1 KO (TSC1CKOER) mice were generated. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | The functional effects of mTORC1 in OA initiation and development on its downstream targets were examined by immunostaining, western blotting and qPCR. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Articular chondrocyte mTORC1 was activated in early-stage OA and in aged mice. | 28043938 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | mTORC1 activation stimulates articular chondrocyte proliferation and differentiation to initiate OA, in part by downregulating FGFR3 and PPR. | 28043938 |
| Communicable Diseases, Helicobacter pylori, Metabolic Syndrome X, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Some studies have suggested that Helicobacter pylori (H. Pylori) infection was associated with insulin resistance and metabolic syndrome, which may increase the risk of chronic kidney disease (CKD). | 28044235 |
| Dyslipidemias | Deregulated Nutrient Sensing | Major risk factors were smoking (19.6%), dyslipidemia (48.8%), and CVD (41%). | 28045952 |
| Postoperative cognitive dysfunction | Deregulated Nutrient Sensing | Insulin resistance plays a potential role in postoperative cognitive dysfunction in patients following cardiac valve surgery. | 28048971 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Severe insulin resistance (IR) promotes the development of Alzheimer disease. | 28048971 |
| Carotid Atherosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | High baPWV was a stronger predictor of early carotid atherosclerosis than high BP, dyslipidemia, or IFG in a Japanese general male population. | 28049936 |
| Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | Insulin resistance represents one of the mechanisms underlying the link between type 2 diabetes (T2D) and Alzheimer's disease (AD), and we explored its in vivo neurobiology related to cognition based on a pathway-based genetic association analyses. | 28050343 |
| Impaired cognition | Deregulated Nutrient Sensing | Eighty-seven mild cognitive impairment (MCIs) subjects and 135 matched controls (HCs) were employed at baseline, and they underwent functional MRI scans, clinical evaluations and exon sequencings of 20 genes related to brain insulin resistance. | 28050343 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. | 28052003 |
| Pancreatic carcinoma | Deregulated Nutrient Sensing | These results indicate that miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1. | 28052003 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | The mechanisms underlying RORa reduction is due to the reduced activation of AMP-activated protein kinase (AMPK), as a selective AMPK activator AICAR increased RORa activation and level in human gastric cancer cells. | 28052040 |
| Stomach Carcinoma, Neoplasms | Deregulated Nutrient Sensing | Taken together, RORa reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMPK. | 28052040 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Therefore, both RORa and AMPK are potential targets for the intervention and therapy in gastric carcinoma. | 28052040 |
| Dyslipidemias | Deregulated Nutrient Sensing | Therefore, non-HDL-C may be a more suitable target of dyslipidemia treatment than LDL-C in patients after AMI. | 28056802 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The efficacy and safety of co-administration of fimasartan and rosuvastatin to patients with hypertension and dyslipidemia. | 28057081 |
| Hypertension, CTCAE, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Hypertension and dyslipidemia are major risk factors of cardiovascular disease (CVD) events. | 28057081 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association between thyroid hormone parameters and dyslipidemia among type 2 diabetes mellitus patients: Comparative cross-sectional study. | 28057507 |
| Dyslipidemias | Deregulated Nutrient Sensing | The aim of the current study was to assess the association between thyroid hormone parameters and dyslipidemia in T2DM and non-diabetic study participants. | 28057507 |
| Dyslipidemias, Lung diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | The type (dyslipidemia, hypertension, pulmonary disease) and the number of comorbidities influenced the choice towards ABA (p = 0.01). | 28058538 |
| Refractory anemias, Dyslipidemias, Lung diseases | Deregulated Nutrient Sensing | Multinomial logistic regression demonstrated that a second-line treatment, higher age, dyslipidemia, pulmonary disease, other comorbidities, and extra-articular RA manifestations were associated with ABA compared to TNFi. | 28058538 |
| Overweight | Deregulated Nutrient Sensing | Triglyceride to HDL-C Ratio is Associated with Insulin Resistance in Overweight and Obese Children. | 28059134 |
| TG gene, Overweight | Deregulated Nutrient Sensing | The purpose of this study was to investigate the usefulness of triglyceride to hdl-c ratio (TG:HDL-C) as an insulin resistance (IR) marker for overweight and obese children. | 28059134 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients. | 28061480 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Towards this, we used patient tissues representing different stages of gastric cancer including gastric pre-cancerous lesions, early gastric cancer, and advanced gastric cancer, and probed SIRT1, STAT3 and phosphorylated STAT3 (pSTAT3) levels using immunohistochemistry. | 28061480 |
| Gastric mucosa, Stomach Neoplasms, Stomach Carcinoma | Deregulated Nutrient Sensing | Our results revealed upregulated expression of SIRT1 in all stages of gastric cancer compared with noncancerous gastric mucosa, suggesting that high SIRT1 levels are likely involved in establishing gastric neoplasticity. | 28061480 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Moreover, co-ordinated high expression of SIRT1 and STAT3 predicted poor overall survival for advanced gastric cancer patients. | 28061480 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | We postulate that SIRT1 and STAT3 are potential early diagnostic and prognostic markers of gastric cancer. | 28061480 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Hypertensive disease, Prediabetes syndrome | Deregulated Nutrient Sensing | Individuals with IFG (prediabetes) and diabetes were merged each for positive cases of dyslipidaemia, high blood pressure (HBP) or obesity. | 28061844 |
| Diabetic Retinopathy, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Macular edema due to diabetes mellitus | Deregulated Nutrient Sensing | To investigate the effects of dyslipidemia and statin therapy on progression of diabetic retinopathy and diabetic macular edema in patients with type 2 diabetes. | 28061854 |
| Malignant neoplasm of endometrium | Deregulated Nutrient Sensing | Women receiving multiple types of medications over a long time had the highest risk, implying that the extent of insulin resistance, rather than the effect of any specific medication, drives endometrial cancer risk. | 28062022 |
| Steatohepatitis, Fibrosis Assessment | Deregulated Nutrient Sensing | The associations of breath 13CO2 levels with hepatic steatosis, fibrosis and insulin resistance was evaluated using laboratory data, elastography results and liver histology findings. | 28062946 |
| Steatohepatitis, Fibrosis Assessment | Deregulated Nutrient Sensing | The 13CO2 excretion of e-NASH patients was significantly correlated with the degree of hepatic steatosis, fibrosis and insulin resistance (P = 0.005, P < 0.001, P = 0.019, respectively). | 28062946 |
| Hyperglycemia, Pancreatitis, Lipolysis | Deregulated Nutrient Sensing | Overall, patients with chronic hyperglycemia after acute pancreatitis appear to have a lipid profile indicative of an up-regulation of lipolysis, which is not significantly affected by either general or adipose tissue-specific insulin resistance. | 28065464 |
| Pancreatitis, Dyslipidemias | Deregulated Nutrient Sensing | The importance of dyslipidemia is well recognized in the context of both risk factor for acute pancreatitis and prognostic factor for its in-hospital outcomes. | 28065464 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Most people with hypertension received specific drug treatment but only half of them reached target values; dyslipidemia treatment showed similar data. | 28065677 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | To find the risk of dyslipidaemia in diabetic patients of different age groups. | 28065951 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer. | 28070138 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Dyslipidaemia plays a key role in the pathogenesis of type 2 diabetes. | 28070639 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Objectives: Omentin-1, an adipocytokine that increases the insulin sensitivity, has been determined to be reduced in patients with insulin resistance, impaired glucose tolerance, and Type-2 diabetes mellitus. | 28073124 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | Testosterone Plasma Concentration is Associated with Insulin Resistance in Male Hypertensive Patients. | 28073130 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Background: Low testosterone levels are a common finding among men with Type 2 Diabetes Mellitus (T2DM) and are inversely related to insulin resistance. | 28073130 |
| Rheumatoid Arthritis, Dyslipidemias | Deregulated Nutrient Sensing | Management of dyslipidaemia in high-risk patients with recent-onset rheumatoid arthritis: targets still not met despite specific recommendations. | 28079508 |
| Refractory anemias, Dyslipidemias | Deregulated Nutrient Sensing | Specific recommendations for RA published in 2006 decreased LDLc target but did not improve management of dyslipidaemia in daily life which remained suboptimal particularly in patients at highest risk. | 28079508 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Both MS and insulin resistance were independent risk factors of incident CKD and rapid decline of eGFR in healthy Korean population. | 28081778 |
| Connective Tissue Diseases | Deregulated Nutrient Sensing | Successful treatment of type B insulin resistance with mixed connective tissue disease by pulse glucocorticoids and cyclophosphamide. | 28084020 |
| Lipodystrophy | Deregulated Nutrient Sensing | Glucagon-like peptide-1 analogues - an efficient therapeutic option for the severe insulin resistance of lipodystrophic syndromes: two case reports. | 28086952 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These complications are generally difficult to treat, particularly diabetes, due to severe insulin resistance. | 28086952 |
| Metabolic Diseases, Dyslipidemias, Diabetes Mellitus, Lipodystrophy, Fatty Liver Disease | Deregulated Nutrient Sensing | Lipodystrophic syndromes are uncommon medical conditions which are normally associated with metabolic disorders, such as diabetes mellitus, dyslipidemia, and fatty liver disease. | 28086952 |
| Dyslipidemias, Cerebrovascular accident, Chronic lung disease, Peripheral Vascular Diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Increasing age was associated with more comorbidities (dyslipidemia, hypertension, prior coronary artery bypass graft surgery, prior stroke, peripheral arterial disease, and chronic lung disease) and more lesion calcification. | 28089997 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To determine whether sclerostin is associated with fasting glucose, insulin levels, insulin resistance or increased risk of incident type 2 diabetes. | 28090669 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. | 28091434 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Risk of hypertension, dyslipidemia, and overweight/obesity in initially underweight Soldiers was 40%, 31%, and 79% lower, respectively, versus normal-weight Soldiers. | 28095509 |
| Lewy Bodies, Dopaminergic Neurons | Deregulated Nutrient Sensing | Here we show that a-synuclein binds phosphoinositide-3 kinase enhancer L (PIKE-L) in a phosphorylation-dependent manner and sequesters it in Lewy bodies, leading to dopaminergic cell death via AMP-activated protein kinase (AMPK) hyperactivation. | 28096359 |
| Dopaminergic Neurons | Deregulated Nutrient Sensing | a-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. | 28096359 |
| Synucleinopathies, neuron death | Deregulated Nutrient Sensing | Hence, our findings demonstrate that a-synuclein neutralizes PIKE-L's neuroprotective actions in synucleinopathies, triggering dopaminergic neuronal death by hyperactivating AMPK. | 28096359 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Insulin resistance in predialytic, nondiabetic, chronic kidney disease patients: A hospital-based study in Eastern Uttar Pradesh, India. | 28098101 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The objective of this study was to examine the degree and determinants of insulin resistance (IR) in predialytic, nondiabetic, CKD patients. | 28098101 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Seventeen patients had dyslipidemia when diabetes was discovered. | 28099349 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Of 13 patients who had received either oral hypoglycemic drugs or insulin, 2 patients achieved well-controlled hemoglobin A1c without hypoglycemic drugs, and 10 patients had hemoglobin A1c 5.0% to 7.7% with the continued use of hypoglycemic drugs.We demonstrated that almost all patients who developed quetiapine-associated diabetes had dyslipidemia and increased BMI. | 28099349 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Exposure to bisphenols and phthalates and association with oxidant stress, insulin resistance, and endothelial dysfunction in children. | 28099427 |
| Albuminuria | Deregulated Nutrient Sensing | Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children. | 28099427 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The ASA group was older, had higher frequency of dyslipidemia and hypertension, and lower renal function than the non-ASA group. | 28100879 |
| Alzheimers Disease", Atrophic | Deregulated Nutrient Sensing | Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease. | 28105773 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Brain insulin resistance (IR), which depends on insulin-receptor-substrate-1 (IRS-1) phosphorylation, is characteristic of Alzheimer's disease (AD). | 28105773 |
| Dyslipidemias, Snoring, Obesity | Deregulated Nutrient Sensing | Self-Reported Snoring Is Associated with Dyslipidemia, High Total Cholesterol, and High Low-Density Lipoprotein Cholesterol in Obesity: A Cross-Sectional Study from a Rural Area of China. | 28106727 |
| CD55 gene, Dyslipidemias, Snoring | Deregulated Nutrient Sensing | Studies to explore the relationship between self-reported snoring and dyslipidemia, especially high total cholesterol (TC) and high low-density lipoprotein cholesterol (LDL-C), in the general population are still lacking. | 28106727 |
| Dyslipidemias, Snoring | Deregulated Nutrient Sensing | After adjustment for all confounding factors, self-reported snoring (OR = 1.207; p = 0.003), moderate (OR = 1.229; p = 0.015), strong (OR = 1.222; p = 0.033), and very strong (OR = 1.467; p = 0.012) snoring intensity, but not low (OR = 1.110; p = 0.224) snoring intensity, were significantly associated with dyslipidemia among adults with BMI (body mass index) >= 25 kg/m2. | 28106727 |
| Dyslipidemias, Snoring | Deregulated Nutrient Sensing | In conclusion, adults with BMI >= 25 kg/m2 and who experience snoring, especially moderate, strong, and very strong intensity levels of snoring, should be on the alert regarding the possibility of dyslipidemia, especially high LDL-C and high TC. | 28106727 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Cognitive function and insulin resistance in elderly patients with type 2 diabetes. | 28107806 |
| Impaired cognition, Diabetes Mellitus | Deregulated Nutrient Sensing | To explore the relationship between cognitive impairment and insulin resistance (IR) in elderly patients with type-2 diabetes mellitus. | 28107806 |
| Prediabetes syndrome, Cerebrovascular accident | Deregulated Nutrient Sensing | Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke. | 28108466 |
| Ischemic stroke | Deregulated Nutrient Sensing | This study aimed to estimate the association between post-glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke. | 28108466 |
| Ischemic stroke | Deregulated Nutrient Sensing | In this large-scale registry, post-glucose load measures of insulin resistance with the ISI(composite) and the ISI0,120 were associated with 12-month poor outcomes of nondiabetic patients with ischemic stroke. | 28108466 |
| Obesity | Deregulated Nutrient Sensing | We identified an association between SIRT1 variation and pediatric obesity in Korean children with a gender difference. | 28118644 |
| Tumor necrosis | Deregulated Nutrient Sensing | Loss of LKB1 was associated with reduced AMPK activation in PDXs and increased tumor necrosis following bevacizumab administration, highlighting impaired control of the metabolic stress caused by this antiangiogenic drug.Conclusions: Our data hint at a possible predictive impact of LKB1 expression in patients with aNSCLC treated with chemotherapy plus bevacizumab. | 28119362 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Management Status of Cardiovascular Disease Risk Factors for Dyslipidemia among Korean Adults. | 28120563 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia, hypertension, and diabetes are well-established risk factors for cardiovascular disease (CVD). | 28120563 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The age-standardized prevalence was highest for dyslipidemia (39.6%), followed by hypertension (32.8%) and diabetes (9.8%). | 28120563 |
| Dyslipidemias | Deregulated Nutrient Sensing | The lowest patient awareness was found for dyslipidemia (27.9%). | 28120563 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The treatment rate was 66.5% for diabetes and 57.3% for hypertension, but only 15.7% for dyslipidemia. | 28120563 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The control rate among those undergoing treatment was highest for hypertension (64.2%), followed by dyslipidemia (59.2%) and diabetes (22.1%). | 28120563 |
| Dyslipidemias | Deregulated Nutrient Sensing | The higher the risk levels of CVD were, the lower the control rate of dyslipidemia. | 28120563 |
| Dyslipidemias | Deregulated Nutrient Sensing | Higher CVD-risk categories showed lower control rates of dyslipidemia. | 28120563 |
| PGLS gene | Deregulated Nutrient Sensing | Total mTOR, p-S6K and p-S6, and mTORC1-associated molecules p-Raptor and p-AMPK were all significantly overexpressed in PGLs rather than in PCCs, and in the head and neck rather than in abdominal locations. | 28122379 |
| Paraganglioma | Deregulated Nutrient Sensing | The mTORC1 Complex Is Significantly Overactivated in SDHX-Mutated Paragangliomas. | 28122379 |
| Neoplasms | Deregulated Nutrient Sensing | Within cluster 1, molecules active in the mTORC1 complex were significantly overexpressed in SDHX- as compared to VHL-mutated tumors. | 28122379 |
| Dyslipidemias, Coronary heart disease, Cerebrovascular accident | Deregulated Nutrient Sensing | Triglyceride and HDL-C Dyslipidemia and Risks of Coronary Heart Disease and Ischemic Stroke by Glycemic Dysregulation Status: The Strong Heart Study. | 28122840 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Sex, diabetes, dyslipidemia, and prior MI were similar for all tertiles. | 28125604 |
| Demographics Domain, Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | In prior myocardial infarction (PMI) patients, diabetes mellitus (DM), dyslipidemia, and hypertension increase the risk of secondary cardiovascular events. | 28125968 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes patients with PMI had significantly lower EPA/AA and DHA/AA than diabetes patients without PMI (EPA/AA: P <0.01; DHA/AA: P =0.003), with no such differences in dyslipidemia and hypertension patients. | 28125968 |
| Hyperandrogenemia, Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | Studies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS). | 28125989 |
| Aortic valve calcification | Deregulated Nutrient Sensing | Insulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification. | 28127113 |
| Cardiovascular calcification, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results. | 28127113 |
| SLC25A20 gene, Aortic valve calcification | Deregulated Nutrient Sensing | The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0). | 28127113 |
| Dyslipidemias, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | Obesity-related diseases were defined as type 2 diabetes, hypertension, dyslipidemia and non-alcoholic fatty liver disease (NAFLD). | 28128316 |
| Dyslipidemias, Diabetes Mellitus, Non-alcoholic Fatty Liver Disease, Obesity, Prediabetes syndrome, Overweight | Deregulated Nutrient Sensing | The age-standardized prevalence of obesity, overweight, diabetes, pre-diabetes, dyslipidemia and NAFLD increased from 2007 to 2013 from 15.82% to 19.41%, 35.85% to 41.80%, 6.37% to 9.23%, 16.77% to 23.49%., 53.46% to 65.50%, and 23.48% to 44.31% in males, respectively, and from 13.18% to 18.77%, 31.11% to 37.54%, 4.41% to 8.48%, 8.10% to 16.49%, 41.96% to 54.70%, and 17.56% to 43.06% in females, respectively. | 28128316 |
| Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Thyroid Diseases, Chronic Obstructive Airway Disease, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | In models adjusted for age, gender, race, hypertension, diabetes, obesity, dyslipidemia, previous cardiovascular disease, smoking, cancer, chronic obstructive airway disease, thyroid disease, and serum creatinine, higher RHR was associated with increased risk of both cardiovascular mortality and noncardiovascular mortality with a relatively similar magnitude of risk (HR 1.19, 95% CI 1.12 to 1.26 and HR 1.23, 95% CI 1.17 to 1.29, respectively). | 28132682 |
| Non-alcoholic Fatty Liver Disease, Liver Stiffness | Deregulated Nutrient Sensing | A "healthy diet-optimal sleep" lifestyle pattern is inversely associated with liver stiffness and insulin resistance in patients with nonalcoholic fatty liver disease. | 28133993 |
| Non-alcoholic Fatty Liver Disease, Liver Stiffness | Deregulated Nutrient Sensing | A "healthy diet-optimal sleep" lifestyle pattern was beneficially associated with insulin resistance and liver stiffness in NAFLD patients independent of body weight status and energy intake. | 28133993 |
| Glucose Intolerance (disease), Haploinsufficiency, FAM126A gene | Deregulated Nutrient Sensing | We have previously described that haploinsufficiency of nuclear receptor coactivator 5 (NCOA5) is a genetic defect linking glucose intolerance to HCC. | 28137631 |
| Data types - Address | Deregulated Nutrient Sensing | We find that selenomethionine promotes the initiation of autophagy via the AMPK-mTOR pathway and enhances autophagic flux, thereby facilitating tau clearance in vivo and in vitro We have now identified an additional, novel mechanism by which selenomethionine improves the cognitive function of AD mice. | 28137967 |
| Obesity | Deregulated Nutrient Sensing | FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study. | 28139438 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We assessed the association of FSH levels with diabetes and measures of insulin resistance among 588 postmenopausal Finnish women. | 28141661 |
| Autoimmune Diseases, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia was associated with a 44% increased risk of thyroid autoimmunity (OR: 1.44, p = 0.01) and a percentage increase in HbA1c was associated with 46% increased risk of thyroid autoimmunity (OR:1.46, p < 0.0001). | 28143459 |
| Autoimmune Diseases, Thyroid dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | Thyroid autoimmunity in T2DM subjects was significantly associated with female gender, thyroid dysfunction, dyslipidaemia and poor glycemic control. | 28143459 |
| Impaired T cell function | Deregulated Nutrient Sensing | Peripheral insulin resistance rather than beta cell dysfunction accounts for geographical differences in impaired fasting blood glucose among sub-Saharan African individuals: findings from the RODAM study. | 28144712 |
| Impaired T cell function | Deregulated Nutrient Sensing | Our findings suggest that insulin resistance, rather than beta cell dysfunction, is more important in accounting for the geographical differences in IFBG among sub-Saharan African individuals. | 28144712 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Relationship between insulin resistance, hs-CRP, and body fat and serum osteoprotegerin/RANKL in prediabetic patients. | 28146138 |
| Inflammation | Deregulated Nutrient Sensing | Growing evidence suggest that there is link between inflammation, insulin resistance and OPG, soluble RANKL (sRANKL). | 28146138 |
| Impaired cognition, Diabetes Mellitus | Deregulated Nutrient Sensing | People with insulin resistance and type 2 diabetes mellitus (T2DM) are at increased risks of cognitive impairment. | 28146431 |
| Presenile dementia, "Alzheimers Disease", Glucose Intolerance (disease), Atherosclerosis | Deregulated Nutrient Sensing | Midlife cholesterol predicted dementia with vascular features, but midlife vascular risk factors and glucose intolerance were not related to pure Alzheimer disease without concomitant atherosclerotic cardiovascular disease. | 28151011 |
| Cerebrovascular accident, Coronary heart disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study. | 28154164 |
| Cardiovascular Diseases, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Studies exploring the association between insulin resistance (IR) and cardiovascular disease in blacks have not been conclusive, especially for coronary heart disease (CHD). | 28154164 |
| AHSG protein, human | Deregulated Nutrient Sensing | Fetuin-A as an Alternative Marker for Insulin Resistance and Cardiovascular Risk in Prepubertal Children. | 28154244 |
| AHSG protein, human, Cardiovascular Diseases | Deregulated Nutrient Sensing | Fetuin-A plays a role in insulin resistance and cardiovascular disease. | 28154244 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Ninety-two per cent of participants had concomitant hypertension (57.5%), dyslipidaemia (26.7%) and eye disease (7.2%). | 28155315 |
| Nerve Degeneration | Deregulated Nutrient Sensing | However, while the roles of AMPK as a metabolic mediator are generally well understood, its performance in neuroprotection and neurodegeneration are not yet well defined. | 28159472 |
| Hyperglycemia | Deregulated Nutrient Sensing | Given hyperglycemia is accompanied by an accelerated rate of advanced glycosylation end product (AGE) formation, which is associated with the pathogenesis of diabetic neuronal impairment and, inflammatory response, clarification of the role of AMPK signaling in these processes is needed. | 28159472 |
| Neurologic Deficits, Prediabetes syndrome | Deregulated Nutrient Sensing | Therefore, we tested the hypothesis that metformin, an AMPK activator, protects against diabetic AGE induced neuronal impairment in human neural stem cells (hNSCs). | 28159472 |
| Nerve Degeneration, diabetic | Deregulated Nutrient Sensing | These findings extend our understanding of the central role of AMPK in AGE induced inflammatory responses, which increase the risk of neurodegeneration in diabetic patients. | 28159472 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | The development of new-onset CV risk factors after LT, such as dyslipidemia and obesity, independently affected late CV morbidity and mortality. | 28160394 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Preexisting CV risk factors, immunosuppressive drugs, but also the early new onset of obesity and dyslipidemia after LT play an important role on late CV complications. | 28160394 |
| Inflammation | Deregulated Nutrient Sensing | Decreased visfatin/Nampt, SIRT1 and SIRT3 in syncytiotrophoblast in PE suggests a lack of placental reserve in metabolic energy efficiency, increased inflammation, and lower resistance to environmental stressors. | 28161061 |
| Obesity | Deregulated Nutrient Sensing | Hyperandrogenic states and obesity in women are associated with insulin-resistance. | 28161330 |
| Hyperlipidemia, Demographics Domain, Presenile dementia, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | The pathophysiology of insulin resistance-induced hypertension and hyperlipidemia might entail differences in dementia risk in cases with hypertension and hyperlipidemia without prior diabetes mellitus (DM). | 28162091 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | Several studies have reported that the overexpression of Sirtuin1 (SIRT1) was associated with poor prognosis in various human cancers. | 28164517 |
| Adenocarcinoma of lung (disorder) | Deregulated Nutrient Sensing | However, little is known regarding the prognostic value of SIRT1 in lung adenocarcinoma. | 28164517 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity among pregnant women is common, and their offspring are predisposed to obesity, insulin resistance, and diabetes. | 28165405 |
| Cardiovascular Diseases, Osage language, Sleep Disorders, Obesity, Sleep Apnea, Obstructive, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obstructive sleep apnoea (OSA) is among the most common sleep disorders and an inter-relationship between OSA, insulin resistance, obesity, type 2 diabetes (T2DM) and cardiovascular diseases has been established. | 28166768 |
| Obesity | Deregulated Nutrient Sensing | Vitamin D status is not related to insulin resistance in different phenotypes of moderate obesity. | 28177726 |
| Obesity | Deregulated Nutrient Sensing | Low plasma 25-hydroxy-vitamin D (25OHD) and high levels of parathyroid hormone (PTH) are associated with obesity and could play a role in the occurrence of complications such as insulin resistance. | 28177726 |
| Obesity | Deregulated Nutrient Sensing | Our results confirm the absence of link between vitamin D status and insulin resistance in moderate obesity. | 28177726 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We excluded participants taking medication for hypertension, dyslipidemia, or diabetes. | 28178938 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | In this study, we demonstrate that the knockdown (KD) of BRG1 promotes cellular senescence by influencing the SIRT1/p53/p21 signal axis in colorectal cancer (CRC). | 28182012 |
| Primary malignant neoplasm, Colorectal Carcinoma | Deregulated Nutrient Sensing | The BRG1/SIRT1/p53 signal axis is a novel mechanism of cell senescence in CRC and is a new potential target for cancer therapy. | 28182012 |
| Metabolic Diseases, Obesity | Deregulated Nutrient Sensing | Insulin resistance (IR) is a hallmark of obesity and metabolic disease. | 28183786 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Adiponectin and leptin are associated with insulin resistance and cardiovascular disease. | 28185529 |
| Barrett Esophagus, Increased insulin level, Adenocarcinoma Of Esophagus | Deregulated Nutrient Sensing | Insulin-resistance and hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion Barrett's Esophagus (BE). | 28185837 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | A direct link between development of insulin resistance and the presence of chronic inflammation, in case of obesity exists, with cytokines playing an important role in glucose metabolism. | 28186649 |
| Gout, Dyslipidemias, Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | CCAAs often herald an ischaemic stroke and may be seen on the PIs of patients with gout, especially those with increased age, dyslipidaemia or diabetes. | 28186844 |
| Pulmonary Emphysema | Deregulated Nutrient Sensing | AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. | 28186975 |
| Pulmonary Emphysema | Deregulated Nutrient Sensing | However, there are no studies regarding the role of AMPK in reducing inflammatory responses and cellular senescence during the development of emphysema. | 28186975 |
| Lung Injury | Deregulated Nutrient Sensing | Therefore, we hypothesize that AMPK reduces inflammatroy responses, senescence, and lung injury. | 28186975 |
| Pulmonary Emphysema | Deregulated Nutrient Sensing | Elastase injection was performed to induce mouse emphysema, and these mice were treated with a specific AMPK activator metformin as well as Compound C. AICAR reduced, whereas Compound C increased CSE-induced increase in IL-8 and IL-6 release and expression of genes involved in cellular senescence. | 28186975 |
| Hyperglycemia, Coronary Arteriosclerosis | Deregulated Nutrient Sensing | This finding suggests that beyond insulin resistance that is present in MS, hyperglycemia may also play a role in the development of atherosclerotic disease. | 28187174 |
| HDL Phospholipid Measurement | Deregulated Nutrient Sensing | BMI, waist circumference, abdominal visceral adiposity and insulin resistance were associated with more total and small LDL-P, fewer large HDL-P, and a reduction in HDL size (P < 0.05). | 28187765 |
| Inflammation, Blood Vessel, Antihypertensive Agents | Deregulated Nutrient Sensing | We investigated whether Southern Italy resistant hypertensives presented an association between the presence of I and/or D alleles and early vascular damage, inflammation, and insulin resistance. | 28190172 |
| Blood Vessel, Antihypertensive Agents | Deregulated Nutrient Sensing | Vascular damage may develop and progress independently from other risk factors in resistant hypertensives, likely through the interplay between ACE gene, RAS activity, and insulin resistance. | 28190172 |
| Psoriatic Juvenile Idiopathic Arthritis, Dyslipidemias, PROS1 gene | Deregulated Nutrient Sensing | Of psoriatic patients, 10.8% had PsA, and after adjusting for age and sex, PsA patients had a significantly higher risk of dyslipidemia than PsV patients (adjusted HR, 1.185; 95% CI, 1.049-1.338). | 28191654 |
| Progeria | Deregulated Nutrient Sensing | Metformin treatment partially restored normal nuclear phenotypes, delayed senescence, activated the phosphorylation of AMP-activated protein kinase and decreased reactive oxygen species formation in HGPS dermal fibroblasts. | 28192606 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | These changes put individuals at risk for insulin resistance, type II diabetes, and cardiovascular disease. | 28193782 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | During these time periods, there were also significant increases in obesity (29.8 vs. 36.6%), diabetes (8.3 vs. 11.9%), and insulin resistance (34.7 vs. 42.1%); P value <0.005 for all of them. | 28195177 |
| melanoma | Deregulated Nutrient Sensing | Insulin resistance has been associated with increased melanoma risk. | 28196548 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. | 28196738 |
| Dyslipidemias | Deregulated Nutrient Sensing | These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions. | 28196738 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Diabetes Mellitus, Bundle-Branch Block, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Upgrade patients were more often implanted for secondary prevention, suffered more often from atrial fibrillation, chronic kidney disease, diabetes mellitus, and dyslipidemia, and had more often a non-LBBB (left bundle branch block) wide QRS complex, and lower left ventricular ejection fraction. | 28202628 |
| Abnormality of mitochondrial metabolism, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin Resistance in Youth Without Diabetes Is Not Related to Muscle Mitochondrial Dysfunction. | 28204552 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity, insulin resistance (IR), and diabetes are increasing in youth, especially in girls. | 28204552 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Cross-sectional study of youth in the Exploring Perinatal Outcomes among Children, Resistance to InSulin in Type 1 And Type 2 diabetes, and Androgens and Insulin Resistance Study cohorts. | 28204552 |
| Lymphoma | Deregulated Nutrient Sensing | Efficacy of the oral mTORC1 inhibitor everolimus in relapsed or refractory indolent lymphoma. | 28211162 |
| Lymphoma | Deregulated Nutrient Sensing | We investigated in a phase II open label clinical trial the efficacy and safety of single agent everolimus, an inhibitor of mTORC1, in patients with relapsed/refractory indolent lymphomas. | 28211162 |
| Hypertension, CTCAE, Demographics Domain, Dyslipidemias | Deregulated Nutrient Sensing | Further analysis demonstrated that the association between parity and hypertension, DM, and LQTc was mediated by lifestyle and dyslipidemia. | 28211485 |
| Obesity | Deregulated Nutrient Sensing | CV risk increased in all obesity phenotypes based on insulin resistance except the insulin resistance-normal weight group. | 28213199 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Fisetin inhibits IL-1b-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice. | 28213268 |
| Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes. | 28214690 |
| Dyslipidemias, Hypothyroidism, Hyperthyroidism, Coronary heart disease, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dystonia Disorders | Deregulated Nutrient Sensing | Adult-onset dystonia patients and the Italian population shared similar burden of arterial hypertension, type 2 diabetes, coronary heart disease, dyslipidemia, and hypothyroidism, while hyperthyroidism was more frequent in the dystonia population. | 28215037 |
| Prediabetes syndrome, diabetic | Deregulated Nutrient Sensing | Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance. | 28216543 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Evidence has shown that endoplasmic reticulum (ER) stress was involved in the progression to type 2 diabetes mellitus (T2DM) and development of insulin resistance. | 28216543 |
| Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | Prevalence of insulin resistance is increased in patients with obstructive sleep apnea (OSA). | 28219664 |
| Cardiovascular Diseases, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Osage language | Deregulated Nutrient Sensing | Because insulin resistance is an independent predictor of cardiovascular disease (CVD), this study was initiated to see if pioglitazone administration would improve insulin sensitivity and thereby decrease risk of CVD in overweight/obese, nondiabetic, insulin-resistant patients with untreated OSA. | 28219664 |
| Osage language | Deregulated Nutrient Sensing | In conclusion, enhanced insulin sensitivity can significantly decrease multiple cardiometabolic risk factors in patients with untreated OSA, consistent with the view that coexisting insulin resistance plays an important role in the association between OSA and increased risk of CVD. | 28219664 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Additionally, we quantified the effect of insulin resistance in the association between serum magnesium levels and diabetes risk. | 28224192 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | We found that 29.1% of the effect of serum magnesium levels on diabetes was mediated through insulin resistance, whereas for prediabetes 13.4% was mediated through insulin resistance. | 28224192 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Both findings support a potential causal role of magnesium in the development of diabetes, where the hypothesised pathway is partly mediated through insulin resistance. | 28224192 |
| Obesity, Abdominal, ETV3 wt Allele | Deregulated Nutrient Sensing | Insulin resistance indices and abdominal obesity (trunk fat mass/percent) increased across the ferritin concentration quartiles after adjustment for confounders in males and females (P <= 0.011 for trend), and the risk of MetS increased across the ferritin quartiles in males (P < 0.001 for trend) and females (P = 0.001 for trend). | 28225503 |
| Obesity, Abdominal, ETV3 wt Allele | Deregulated Nutrient Sensing | The highest serum ferritin quartile exhibited a 1.62-fold increased risk of MetS (95% CI, 1.28-2.12) in males and a 1.36-fold increased risk of MetS (95% CI, 1.09-1.69) in females compared with the lowest quartile after adjustment for confounders.Our results suggest that ferritin is associated with insulin resistance and abdominal obesity. | 28225503 |
| Hypertension, CTCAE, Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. | 28225861 |
| Impaired cognition | Deregulated Nutrient Sensing | Cognitive impairment is correlated with insulin resistance degree: the "PA-NICO-study". | 28229380 |
| Presenile dementia, Demographics Domain, Diabetes Mellitus | Deregulated Nutrient Sensing | Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. | 28229380 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Older age, African-American race, fee-for-service plan, comorbid hypertension, obesity, and dyslipidemia were associated with higher risk for onset of type 2 diabetes. | 28230458 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Six weeks of dapagliflozin treatment resulted in improvements in diabetes control, including blood glucose and insulin resistance, and reduced office and 24-h ambulatory blood pressure values. | 28231831 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Mechanism study reveals that BCAT1 activates the mTOR, but not AMPK or SIRT1, signaling to promote mitochondrial biogenesis and function, and subsequently facilitates growth and colony formation of breast cancer cells. | 28235484 |
| Neoplasms | Deregulated Nutrient Sensing | In addition, expression of several HDACs (HDAC1, HDAC2, HDAC5, HDAC11, and Sirt1) was significantly increased in G3 tumors. | 28235630 |
| Prediabetes syndrome, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke: The ACROSS-China Study (Abnormal Glucose Regulation in Patients With Acute Stroke Across China). | 28235959 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance was common in patients with stroke. | 28235959 |
| Ischemic stroke | Deregulated Nutrient Sensing | This study investigated the association between insulin resistance and outcomes in nondiabetic patients with first-ever acute ischemic stroke. | 28235959 |
| Cessation of life, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance was associated with an increased risk of death, stroke recurrence, and poor outcome but not dependence in nondiabetic patients with acute ischemic stroke. | 28235959 |
| Nucleolar Fibrillar Material | Deregulated Nutrient Sensing | Mechanistically, miR-181b is upregulated in OS and fibrosa, and it targets TIMP3, SIRT1, and GATA6, correlated with increased gelatinase/MMP activity. | 28236165 |
| Hand | Deregulated Nutrient Sensing | Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND. | 28236278 |
| Dyslipidemias | Deregulated Nutrient Sensing | Patients treated with EIAEDs, especially PHT, had higher prevalence of dyslipidemia. | 28239528 |
| Psoriasis, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with severe psoriasis smoked more heavily, were more likely to have diabetes or insulin resistance and had higher homocysteine and lower high density lipoprotein cholesterol (HDL-C) levels than patients with mild psoriasis (P < 0.05). | 28240341 |
| Insulin Resistance, Psoriasis, Diabetes Mellitus | Deregulated Nutrient Sensing | Psoriasis severity was associated with diabetes, insulin-resistance, smoking habit and higher cardiovascular risk. | 28240341 |
| Arthralgia, Dyslipidemias, Splenomegaly, Fatigue | Deregulated Nutrient Sensing | FM-pSS patients significantly showed more constitutional, fatigue and arthralgia symptoms, splenomegaly, genital, skin and ear involvement and dyslipidaemia (p<0.05), as well as higher ESSPRI and SSDAI scores (p<0.01). | 28240585 |
| Arthralgia, Adverse Event Associated with Constitutional Symptoms, Dyslipidemias, Fatigue | Deregulated Nutrient Sensing | The presence of fatigue, arthralgia, constitutional symptoms and dyslipidaemia were more likely to coexist in pSS-FM patients. | 28240585 |
| Hyperglycemia, Endothelial dysfunction | Deregulated Nutrient Sensing | Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth). | 28242270 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. | 28242270 |
| Polycystic Kidney, Autosomal Dominant | Deregulated Nutrient Sensing | Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis. | 28244683 |
| Hyperthyroidism, Dysglycemia, Hypothyroidism | Deregulated Nutrient Sensing | While hyperthyroidism and hypothyroidism cause dysglycemia, the relationship between thyroid hormone levels within the normal range and insulin resistance (IR) is unclear. | 28246105 |
| Cerebrovascular accident, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus. | 28246237 |
| Electrocardiogram: myocardial infarction (finding), Atherosclerosis, Cerebrovascular accident | Deregulated Nutrient Sensing | Insulin resistance is highly prevalent among patients with atherosclerosis and is associated with an increased risk for myocardial infarction (MI) and stroke. | 28246237 |
| Cerebrovascular accident, Ischemic stroke, Diabetes Mellitus | Deregulated Nutrient Sensing | The IRIS trial (Insulin Resistance Intervention after Stroke) demonstrated that pioglitazone decreased the composite risk for fatal or nonfatal stroke and MI in patients with insulin resistance without diabetes mellitus, after a recent ischemic stroke or transient ischemic attack. | 28246237 |
| Cerebrovascular, Acute Coronary Syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | Among patients with insulin resistance without diabetes mellitus, pioglitazone reduced the risk for acute coronary syndromes after a recent cerebrovascular event. | 28246237 |
| Atherosclerosis | Deregulated Nutrient Sensing | Increased serum semaphorin 3E may in part exacerbate insulin resistance and carotid atherosclerosis. | 28249916 |
| Dyslipidemias, Sao Paulo | Deregulated Nutrient Sensing | Considering the high prevalence of low HDL-c in the population of Sao Paulo, GI and GL may contribute to the nutritional therapy of this dyslipidemia. | 28251342 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Comparison of two surrogate estimates of insulin resistance to predict cardiovascular disease in apparently healthy individuals. | 28254109 |
| Congenital Abnormality, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is associated with a cluster of abnormalities that increase cardiovascular disease (CVD). | 28254109 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Kernel Density Estimation as a Measure of Environmental Exposure Related to Insulin Resistance in Breast Cancer Survivors. | 28258052 |
| Dental Plaque | Deregulated Nutrient Sensing | Beyond AdipoR1/AdipoR2 expression, a graded decrease in PPAR-a protein levels was observed in relation to carotid plaque instability (P<0.001), whereas AMPK phosphorylation was increased (P<0.05). | 28258256 |
| FAM126A gene | Deregulated Nutrient Sensing | Mechanistic study showed that BCLB expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC cells through the adenosine monophosphate-activated protein kinase AMPK-mTOR signaling cascade. | 28259820 |
| Liver carcinoma | Deregulated Nutrient Sensing | BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade. | 28259820 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is characterized by islet b-cell dysfunction and insulin resistance, which leads to an inability to maintain blood glucose homeostasis. | 28260062 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is a risk factor for nonalcoholic fatty liver disease (NAFLD). | 28262209 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | The associations of dyslipidemia indexes with NAFLD occurrence were assessed by univariate analysis, and multivariate analysis was performed to identify independent dyslipidemia factors predictive of NAFLD. | 28262209 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | A significant positive association was found between dyslipidemia characteristics and NAFLD in adult males. | 28262209 |
| Autoimmune Diseases, Hyperglycemia | Deregulated Nutrient Sensing | Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. | 28262212 |
| Pliability | Deregulated Nutrient Sensing | However, it is unknown whether metabolic inflexibility causes insulin resistance. | 28262678 |
| Pliability | Deregulated Nutrient Sensing | The early stages of insulin resistance are accompanied by modest declines in the RQs during sleep and during a clamp, with no changes in fasting RQ or signs of metabolic inflexibility. | 28262678 |
| Pliability | Deregulated Nutrient Sensing | Our data therefore suggest that metabolic inflexibility does not cause insulin resistance. | 28262678 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Increased ectopic adipose tissue infiltration in skeletal muscle is associated with insulin resistance and diabetes mellitus. | 28264917 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Our novel findings show that decreased muscle attenuation is associated with newly developed hypertension among men of African ancestry, independent of general and central adiposity and insulin resistance. | 28264917 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | All groups which developed diabetes showed absolute and/or relative increase in visceral fat and impaired b-cell compensation for insulin resistance. | 28266592 |
| B-Lymphocytes, Gain, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | These data suggest that visceral fat gain may induce b-cell failure in compensation for insulin resistance, resulting in diabetes regardless of obesity level. | 28266592 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Psychogenic, Mental disorders | Deregulated Nutrient Sensing | In the multivariate analysis the global score strongly correlated with TT < 12 nmol/L (odds ratio [OR] = 3.17; p < 0.05), psychiatric disorders (OR = 2.73), dyslipidemia (OR = 2.07) and diabetes mellitus (OR = 1.64); the somatic sub-component was related to obesity (OR = 8.62), dyslipidemia (OR = 2.2) and TT < 12 nmol/L (OR = 2.09); the psychogenic sub-component correlated with psychiatric disorders (OR = 3.73), stress (OR = 2.42), dyslipidemia (OR = 1.78) and TT < 12 nmol/L (OR = 1.77); and the sexual sub-component was associated with high blood pressure (OR = 2.94). | 28277894 |
| Obesity | Deregulated Nutrient Sensing | Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine linking obesity to skeletal muscle insulin resistance. | 28278265 |
| Dyslipidemias, Obesity, Visceral | Deregulated Nutrient Sensing | VFA was the strongest predictor of plasma LECT2 that is a potential biomarker linking visceral obesity to dyslipidemia. | 28278265 |
| Obesity | Deregulated Nutrient Sensing | Two members of the lipocalin family, lipocalin-2 (LCN-2) and retinol binding protein -4 (RBP-4), play an important role in obesity and insulin resistance. | 28279688 |
| Glucose Intolerance (disease), Obesity | Deregulated Nutrient Sensing | Glucose intolerance and elevated brain glucose utilization already occur in young, pre-obese rats, suggesting that they precede obesity onset in Zucker fatty rats. | 28281382 |
| Lupus Erythematosus, Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance in systemic lupus erythematosus patients: contributing factors and relationship with subclinical atherosclerosis. | 28281456 |
| Lupus Erythematosus, Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. | 28281456 |
| Cerebral artery stenosis, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Hypertension, CTCAE, Dental Plaque | Deregulated Nutrient Sensing | Multiple logistic regression analysis adjusted for age, gender, diabetes mellitus, dyslipidemia, hypertension, and hyperuricemia showed that a 0.1 increase in VS ratio was related to the presence of ischemic changes [odds ratio (OR): 1.05, 95% CI: 1.01-1.10, p = 0.009], cerebral artery stenosis or occlusion (OR: 1.14, 95% CI: 1.03-1.25, p = 0.007), and cervical plaque (OR: 1.09, 95% CI: 1.05-1.13, p < 0.001). | 28285092 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Chronic kidney disease (CKD) results in significant dyslipidemia and profound changes in lipid and lipoprotein metabolism. | 28286957 |
| Cardiac complication, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The associated dyslipidemia, in turn, contributes to progression of CKD and its cardiovascular complications. | 28286957 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | No associations with morphological LAA features could be found for patients with diabetes, hypertension, or dyslipidemia. | 28288200 |
| Hyperhomocysteinemia, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Previous studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. | 28288621 |
| Obesity | Deregulated Nutrient Sensing | This finding provides evidence that sDPP4 and GLP-1 may play an important role in the pathogenesis of obesity, suggesting that sDPP4 may be valuable as an early marker for the augmented risk of obesity and insulin resistance. | 28288852 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Strong graded associations between screen time, adiposity and insulin resistance suggest that reducing screen time could facilitate early T2D prevention. | 28288985 |
| Obesity | Deregulated Nutrient Sensing | In addition, this positive association was more apparent when insulin resistance was accompanied by obesity. | 28291026 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidaemia as a risk factor in the occurrence of stroke in Nigeria: prevalence and patterns. | 28292035 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Hypertension, diabetes mellitus, dyslipidaemia and smoking are some of the common modifiable risk factors in the occurrence of stroke. | 28292035 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidaemia is the most frequent risk factor (85.9%), followed by hypertension (66.0%) and diabetes mellitus (15.1%). | 28292035 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Dyslipidaemia was significantly higher in the ischaemic stroke compared to haemorrhagic. | 28292035 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidaemia, particularly low HDL-C, was the most frequent risk factor in our patients with stroke. | 28292035 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Hence, prevention of dyslipidaemia as well as other risk factors is key to reducing the burden of stroke in our country. | 28292035 |
| Inflammation, Primary malignant neoplasm, Neoplasms, Obesity | Deregulated Nutrient Sensing | Obesity is associated with tumor promoting pathways related to insulin resistance and chronic low-grade inflammation which have been linked to various disease states, including cancer. | 28293912 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The present study aimed to investigate the association of plasma soluble Ob-R levels with insulin resistance and pancreatic b-cell function in patients with type 2 diabetes. | 28294581 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Plasma soluble Ob-R levels are independently associated with pancreatic b-cell function, but not with insulin resistance, in patients with type 2 diabetes. | 28294581 |
| Cerebrovascular Disorders, Peripheral Vascular Diseases, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The high risk for MD in mild to moderate CKD patients remains significant after adjustment for personal habits (alcohol drinking and smoking, model 1; OR: 1.371; 95% CI: 1.265-1.486; P < 0.001), comorbidities (dyslipidemia, cerebrovascular disease, and peripheral vascular disease, model 2; OR: 1.369; 95% CI: 1.264-1.484; P < 0.001) and all these factors (model 3; OR: 1.320, 95% CI: 1.218-1.431, P < 0.001). | 28296786 |
| Inflammation, Obesity, Abdominal, Miller Dieker syndrome | Deregulated Nutrient Sensing | Furthermore, the association between MDS and fasting glucose was fully mediated by adiposity, especially by WC in men aged <45 y and in premenopausal women.Conclusion: Our results suggest that reducing abdominal obesity may play an important role in the pathway through which Med-diet consumption reduces insulin resistance and inflammation. | 28298537 |
| Atherosclerosis | Deregulated Nutrient Sensing | Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and play significant roles in the development of insulin resistance and atherosclerosis. | 28303004 |
| Atherosclerosis | Deregulated Nutrient Sensing | Both FABP4 and FABP5 are secreted from cells, and their circulating levels are associated with insulin resistance and atherosclerosis. | 28303004 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Secreted frizzled-related protein-5 (Sfrp5) is a novel adipokine, and it has been found to link insulin resistance with diabetes. | 28303637 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease. | 28304291 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum Magnesium Concentrations in the Canadian Population and Associations with Diabetes, Glycemic Regulation, and Insulin Resistance. | 28304338 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This study reports current SMCs of Canadians and their associations with demographic factors, diabetes, and measures of glycemic control and insulin resistance using results from the Canadian Health Measures Survey cycle 3 (2012-2013). | 28304338 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A substantial proportion of Canadians are hypomagnesaemic in relation to a population-based reference interval, and SMC was negatively associated with diabetes and indices of glycemic control and insulin resistance. | 28304338 |
| Prostate carcinoma | Deregulated Nutrient Sensing | The combination of standard dose abiraterone acetate and BEZ235, a pan-class I PI3K and mTORC1/2 inhibitor, was poorly tolerated in men with progressive mCRPC.Although the clinical development of BEZ235 has been discontinued in prostate cancer, agents that more selectively target PI3K-AKT-mTOR signaling may have a more favorable therapeutic index and should continue to be explored. | 28314838 |
| Congenital bilateral aplasia of vas deferens, Dyslipidemias, Diabetes Mellitus, Overweight, Aortic valve disorder | Deregulated Nutrient Sensing | Calcific aortic valve disease (CAVD) affects 2-6% of the population over 65 years, and age, gender, smoking, overweight, dyslipidemia, diabetes contribute to the development of this disease. | 28314924 |
| Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address, Diabetes Mellitus | Deregulated Nutrient Sensing | AD is associated with type 2 diabetes mellitus (T2DM) and insulin resistance, and is therefore sometimes called "type 3 diabetes mellitus". | 28316001 |
| Metabolic Diseases, Refractory anemias, Dyslipidemias, Rheumatoid Arthritis, Chronic inflammatory disorder | Deregulated Nutrient Sensing | Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. | 28316139 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidaemia may affect systemic microvasculature from childhood on. | 28317946 |
| Sarcopenia | Deregulated Nutrient Sensing | White blood cell counts, insulin resistance, vitamin D levels and sarcopenia in Korean elderly men. | 28318372 |
| Inflammation, Sarcopenia | Deregulated Nutrient Sensing | Whether low-grade inflammation, insulin resistance and vitamin D are independently associated with sarcopenia remains unclear. | 28318372 |
| Increased insulin level, Impaired cognition, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes, hyperinsulinemia, and insulin resistance are associated with cognitive impairment. | 28319003 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Our results show that measures of peripheral insulin resistance are unrelated to cognitive performance among individuals with adequately controlled type 2 diabetes. | 28319003 |
| Hypertensive (finding), Dyslipidemias, Retinal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Forty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia). | 28320161 |
| Prostate Cancer Outcomes Study, Cardiovascular Diseases | Deregulated Nutrient Sensing | The increased plasma PAF-AH and apoB-PAF-AH activities in patients with H allele of R92H are related to the R92 - H variation, changes in plasma lipoprotein levels, insulin resistance, aging, and gaining weight and thus may be involved in the pathogenesis of PCOS and the increased risks of future cardiovascular diseases. | 28320416 |
| Inflammation, myocardial injury, Hyperglycemia, Dyslipidemias, physiopathological, Renal Insufficiency | Deregulated Nutrient Sensing | We recruited 533 questionnaire-identified apparently healthy individuals, in which laboratory biomarkers were used to detect asymptomatic myocardial injury and dysfunction, ongoing inflammation, hyperglycemia, dyslipidemia, and renal dysfunction. | 28322756 |
| Increased insulin level | Deregulated Nutrient Sensing | 2-[4-(5-Chlorobenzothiazothiazol-2-yl)phenoxy]-2-methyl-propionic acid (MHY908) has been shown to prevent insulin resistance-induced hyperinsulinemia in aged rats. | 28323024 |
| Nephritis | Deregulated Nutrient Sensing | However, the mechanism underlying MHY908-mediated amelioration of renal inflammation with insulin resistance during aging remains unknown. | 28323024 |
| Fracture | Deregulated Nutrient Sensing | The contribution of insulin resistance vs adiposity to bone mineral density (BMD), bone turnover, and fractures in humans remains unclear. | 28324004 |
| Atrial Fibrillation by ECG Finding, Dyslipidemias, Coronary Arteriosclerosis, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hypertension (58.40%), chronic kidney disease (51.36%), dyslipidaemia (44.62%), ischaemic heart disease (25.75%), and atrial fibrillation (25.32%) were the most represented comorbidities. | 28324597 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | The present case suggests that these differences in epitopes may be related to various pathogenic mechanisms including glucose intolerance. | 28326749 |
| Arthritis, Deafness, Impaired cognition | Deregulated Nutrient Sensing | There were some weak associations between SIRT1 SNPs and arthritis, heart attack, deafness, and cognitive impairment. | 28329314 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is an important independent modifiable risk factor for cardiovascular disease. | 28330492 |
| Overweight and obesity, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Overweight or obesity (OR = 2.156; 95% CI: 1.863, 2.533), hypertension (OR = 1.643; 95% CI: 1.425, 1.893), or diabetes mellitus (OR = 2.173; 95% CI: 1.661, 2.844) increased the prevalence of dyslipidemia, also these participants were more likely to be aware of their condition, however, this did not increase the likelihood of treatment and control. | 28330492 |
| Dyslipidemias | Deregulated Nutrient Sensing | Living in urban areas and higher education level also increased the awareness of dyslipidemia. | 28330492 |
| Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | Personal history of coronary heart disease was the strongest influence factors associated with better awareness, treatment and control of dyslipidemia. | 28330492 |
| Overweight and obesity, Dyslipidemias | Deregulated Nutrient Sensing | Overweight or obesity (OR = 0.404; 95% CI: 0.235, 0.695) and lack of exercise (OR = 0.423; 95% CI: 0.215, 0.830) were associated with poor control of dyslipidemia. | 28330492 |
| Liver carcinoma, CC-223 | Deregulated Nutrient Sensing | CC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo. | 28334043 |
| CC-223, FAM126A gene | Deregulated Nutrient Sensing | CC-223 concurrently blocked mTORC1 and mTORC2 activation, and its cytotoxicity against HCC cells was much more potent than the traditional mTORC1 inhibitors (RAD001 and rapamycin). | 28334043 |
| CC-223 | Deregulated Nutrient Sensing | mTORC1/2 activation was also blocked in xenografts with CC-223 administration. | 28334043 |
| CC-223, FAM126A gene | Deregulated Nutrient Sensing | Together, CC-223 simultaneously blocks mTORC1/2 and efficiently inhibits human HCC cells. | 28334043 |
| Multiple System Atrophy | Deregulated Nutrient Sensing | Insulin resistance and exendin-4 treatment for multiple system atrophy. | 28334990 |
| Atrophic, Multiple System Atrophy | Deregulated Nutrient Sensing | We here tested the hypothesis that multiple system atrophy is associated with brain insulin resistance and showed increased expression of the key downstream messenger insulin receptor substrate-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in the putamen of patients with multiple system atrophy. | 28334990 |
| Atrophic | Deregulated Nutrient Sensing | Increasing evidence also suggests impaired insulin/IGF-1 signalling in multiple system atrophy, as corroborated by increased insulin and IGF-1 plasma concentrations in multiple system atrophy patients and reduced IGF-1 brain levels in a transgenic mouse model of multiple system atrophy. | 28334990 |
| Hypertensive disease, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | In cause-specific hazard models, HTN (adjusted hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.66 to 1.76), diabetes (HR: 1.49; 95% CI: 1.44 to 1.54), and dyslipidemia (HR: 1.17; 95% CI: 1.14 to 1.21) were all significantly associated with increased risk of developing severe AS (all p < 0.001). | 28335833 |
| Chronic Obstructive Airway Disease | Deregulated Nutrient Sensing | LncRNA-mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease. | 28339038 |
| ARCN1 gene | Deregulated Nutrient Sensing | The primary aim of the present study was to explore the mechanisms of AECII senescence regulated by lncRNA-mediated sirtuin 1 (SIRT1) and forkhead box O 3a (FoxO3a) signaling pathways in patients with COPD. | 28339038 |
| ARCN1 gene | Deregulated Nutrient Sensing | Furthermore, the expression levels of senescence-associated lncRNA1 (SAL-RNA1), SIRT1 and FoxO3a were reduced, but SAL-RNA2, SAL-RNA3, p53 and p21 were upregulated in the lung tissues of patients with COPD compared with control. | 28339038 |
| ARCN1 gene | Deregulated Nutrient Sensing | The results of the present study indicated that lncRNA-mediated SIRT1/p53 and FoxO3a signaling pathways may regulate AECII senescence in the pathogenesis of COPD, which may provide a novel experimental basis for the treatment of COPD. | 28339038 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Insulin resistance is associated with carotid intima-media thickness in non-diabetic subjects. | 28340367 |
| Carotid Intima-Media Thickness | Deregulated Nutrient Sensing | Epidemiological studies have analyzed the association between carotid intima-media thickness (CIMT) and insulin resistance, glucose levels or glycated hemoglobin with mixed results. | 28340367 |
| Dyslipidemias, Depression, CTCAE, ETV3 wt Allele, Diabetes Mellitus | Deregulated Nutrient Sensing | Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. | 28341138 |
| Post-Traumatic Stress Disorder, Hypercholesterolemia, Pulmonary Emphysema, Angina Pectoris | Deregulated Nutrient Sensing | PTSD was strongly associated with increased odds for hypercholesterolemia, insulin resistance, angina, heart attack, and emphysema with the greatest odds observed for heart attack (OR= 3.94) and emphysema (OR= 4.06). | 28342139 |
| ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | 25-OHD was inversely correlated with glycemic control and cardiovascular risk components of MetS except HDL-C, insulin resistance, and obesity. | 28346853 |
| ARCN1 gene, Thrombosis, Dyslipidemias, Chronic Obstructive Airway Disease, Obesity | Deregulated Nutrient Sensing | Plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of fibrinolysis, is associated with thrombosis, obesity, insulin resistance, dyslipidemia, and premature aging, which all are coexisting conditions of chronic obstructive pulmonary disease (COPD). | 28356730 |
| Obesity | Deregulated Nutrient Sensing | D status and it is well-known that central obesity, with the inflammatory alterations thereto correlated that determine insulin resistance, can be considered the "primum movens" for the development of MetS. | 28361806 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Overweight and dyslipidemia were significantly associated with low number of steps (<10,000). | 28362075 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | On the other hand, teachers who do not overcome show a greater chance of overweight and dyslipidemia. | 28362075 |
| Fatty degeneration, Abnormality of mitochondrial metabolism | Deregulated Nutrient Sensing | Insulin resistance and hepatic steatosis were associated with increased ATF3 expression and decreased fatty acid oxidation via mitochondrial dysfunction and were attenuated by in vivo ATF3 silencing. | 28365312 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Different inverse association of large high-density lipoprotein subclasses with exacerbation of insulin resistance and incidence of type 2 diabetes: The Nagahama study. | 28365559 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The aim of this study was to clarify the difference in prognostic significance of HDL subclasses for exacerbation of insulin resistance and incidence of type 2 diabetes in the general population. | 28365559 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | HDL may have an antidiabetic function; the prognostic value of HDL2-C for diabetes and insulin resistance might be better than that of HDL3-C. | 28365559 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | Interrelationship between insulin resistance and portal haemodynamic abnormality in cirrhosis. | 28367084 |
| Liver Cirrhosis | Deregulated Nutrient Sensing | The study prospectively examined the interrelationship between insulin resistance (IR) and portal haemodynamic abnormality in cirrhosis. | 28367084 |
| Hyperglycemia, Dyslipidemias, Psoriasis | Deregulated Nutrient Sensing | Psoriasis patients had a higher prevalence of overweight/obesity, hyperglycemia and dyslipidemia when compared with controls. | 28371532 |
| Atherosclerosis | Deregulated Nutrient Sensing | Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. | 28372564 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | The higher FT3/FT4 ratio is associated with increased risk of metabolic syndrome parameters and insulin resistance. | 28374508 |
| Dyslipidemias, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | Statin utilization improves oncologic and survival outcomes in patients with dyslipidemia and surgically treated renal cell carcinoma. | 28376607 |
| Refractory Cytopenia of Childhood, Dyslipidemias, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | We evaluated the role of statins in patients who underwent surgery for renal cell carcinoma (RCC) and who had dyslipidemia, as use of statins has been suggested to improve outcomes in RCC. | 28376607 |
| Refractory Cytopenia of Childhood, Dyslipidemias | Deregulated Nutrient Sensing | Two-center retrospective study of patients with dyslipidemia who underwent surgery for RCC from 7/1995 to 6/2005. | 28376607 |
| Refractory Cytopenia of Childhood, Dyslipidemias | Deregulated Nutrient Sensing | In RCC patients with dyslipidemia, statin use was associated with improved survival outcomes, and was an independent predictor of PFS. | 28376607 |
| Increased insulin level | Deregulated Nutrient Sensing | With the exception of His, which had no association with insulin resistance, Phe, Tyr, Met and Ala were significantly associated with hyperinsulinemia and insulin resistance (P<0.05). | 28378845 |
| Increased insulin level, Dyslipidemias, Hyperglycemia | Deregulated Nutrient Sensing | As a result, PFAAs may serve as metabolite predictors of hyperglycemia, hyperinsulinemia and dyslipidemia in healthy participants. | 28378845 |
| Dyslipidemias, Myocardium, Aortic valve disorder | Deregulated Nutrient Sensing | Myocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible. | 28380047 |
| One Vessel Coronary Disease, Dyslipidemias, Atherosclerosis of artery | Deregulated Nutrient Sensing | Conversely to findings from studies in other Arab and Asian countries, where small vessel disease is the most frequent subtype, our study showed a predominance of large artery atherosclerosis (53.5%) which, in comparison with other subtypes, was found to be associated with dyslipidemia (OR= 3.82, 95% CI= [1.76-8.28]; p=0.001). | 28380323 |
| Impaired cognition | Deregulated Nutrient Sensing | Prevention and treatment of insulin resistance might help reduce cognitive decline later in life. | 28381479 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | In men, obesity was negatively associated with HRQOL through diabetes mellitus, hypertension, and dyslipidemia and positively associated with HRQOL through SRH. | 28382521 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension or type-2 diabetes patients were selected as the CDMP group, while dyslipidemia patients were the control group. | 28383439 |
| Dyslipidemias, Hypothyroidism | Deregulated Nutrient Sensing | Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C). | 28384120 |
| Cerebrovascular Disorders, Dyslipidemias, Hypothyroidism, Atherosclerosis | Deregulated Nutrient Sensing | It is important to determine serum lipid levels, especially serum sdLDL-C levels at an early stage of subclinical hypothyroidism, since they represent atherogenic LDL particles and are better indicators for dyslipidaemia in subclinical hypothyroidism and the development of atherosclerosis with potential complications such as cardiovascular and cerebrovascular diseases. | 28384120 |
| diabetic | Deregulated Nutrient Sensing | Relationship between sleep parameters, insulin resistance and age-adjusted insulin like growth factor-1 score in non diabetic older patients. | 28384333 |
| Sleep Apnea, Obstructive, Osage language | Deregulated Nutrient Sensing | Sleepiness, short or long sleep duration and obstructive sleep apnea (OSA) are associated with insulin resistance (IR). | 28384333 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Subjects with diabetes mellitus, hypertension, and/or dyslipidemia were classified as "metabolically unhealthy." | 28385358 |
| SLC25A20 gene, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Compared to individuals without luminal narrowing or CAC, individuals without luminal narrowing but CAC>0 were older, more likely to be male and had higher rates of diabetes, hypertension, and dyslipidemia. | 28385391 |
| Fibrosis Assessment | Deregulated Nutrient Sensing | Sirtuins (SIRTs), particularly SIRT1, SIRT3, and SIRT6, are well-known mediators of aging; however, limited data exist on the contribution of sirtuins to lung fibrosis. | 28385812 |
| Dyslipidemias | Deregulated Nutrient Sensing | Relationship of serum novel adipokine chemerin levels with body composition, insulin resistance, dyslipidemia and diabesity in Saudi women. | 28387898 |
| ARCN1 gene, Dyslipidemias, Coronary Arteriosclerosis, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Compared to the control group, patients with COPD had a higher risk of dyslipidaemia (OR 3.24, 95% CI; 2.21-4.75), diabetes type 2 (OR 1.52, 95% CI; 1.01-2,28), and ischaemic heart disease (OR 2.34, 95% CI; 1.22-4.49). | 28390852 |
| Dyslipidemias | Deregulated Nutrient Sensing | In the case of dyslipidaemia, an increased risk was obtained when adjusted for age, gender, and consumption of tobacco (OR 5.04, 95% CI; 2.36-10.74). | 28390852 |
| ARCN1 gene, Dyslipidemias, Coronary Arteriosclerosis, Hypertension, CTCAE, Cardiac Arrhythmia | Deregulated Nutrient Sensing | Patients with COPD resident in the Canary Islands have a high prevalence of hypertension, dyslipidaemia, ischaemic heart disease, and cardiac arrhythmia. | 28390852 |
| ARCN1 gene, Dyslipidemias | Deregulated Nutrient Sensing | Compared to general population, patients with COPD have a significant increase in the risk of dyslipidaemia. | 28390852 |
| Obesity | Deregulated Nutrient Sensing | One child developed a deleterious metabolic phenotype with obesity and insulin resistance (homeostatic model assessment = 3.08) associated with higher mean hepatic transaminases (149 vs 98, 88, and 61 IU/L) and increased mean cIMT values (raising from 0.47 to 0.5 mm vs 0.43 and 0.43 mm). | 28391883 |
| Hypertensive disease, Dyslipidemias | Deregulated Nutrient Sensing | DM, HTN and dyslipidemia co-existed in 1.8% of the population. | 28395951 |
| Hypertensive disease, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and dyslipidemia are the most common comorbidities among persons with DM and HTN alone and comorbid DM and HTN. | 28395951 |
| Hypertensive disease, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Factors strongly associated with comorbid DM and HTN include elderly age group, dyslipidemia, obesity and family history of DM. | 28395951 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | The study reported high burden of comorbid diabetes and hypertension among the elderly, strongly associated with obesity and dyslipidemia. | 28395951 |
| Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Hypertension, CTCAE, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Hyperuricemia (defined as >7 mg/dL in men and >=6 mg/dL in women) was associated with increased cumulative incidence of hypertension (14.9% versus 6.1%; P<0.001), dyslipidemia (23.1% versus 15.5%; P<0.001), chronic kidney disease (19.0% versus 10.7%; P<0.001), and overweight/obesity (8.9% versus 3.0%; P<0.001), while diabetes mellitus (1.7% versus 0.9%; P=0.087) showed a trend but did not reach statistical significance. | 28396536 |
| Dyslipidemias, VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | Deregulated Nutrient Sensing | Dyslipidemia was significantly associated with vitiligo (67%) compared with the control group (48%) (OR: 0.44; 95% CI: 0.21-0.92; p=0.03). | 28397947 |
| VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding), Dyslipidemias, Diabetes Mellitus, Hypothyroidism, Chronic disease, Injury of kidney, Obesity | Deregulated Nutrient Sensing | Conclusion: There is an increased risk of chronic diseases among vitiligo patients including diabetes, dyslipidemia, hypothyroidism, renal injuries, and obesity. | 28397947 |
| Periodontitis, Inflammatory disorder, Chronic disease, Cardiovascular Diseases | Deregulated Nutrient Sensing | Periodontitis is an inflammatory disease affecting the tooth supporting tissues (periodontium) and associated with chronic diseases such as cardiovascular disease and insulin resistance. | 28401926 |
| Incontinence, Dyslipidemias, Diabetes Mellitus, Erectile dysfunction, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most common SDg prior to surgery were hypertension, lower urinary tract symptoms, dyslipidemia, diabetes mellitus and erectile dysfunction, but none did show a greater trend towards post-surgical incontinence. | 28403593 |
| Gestational Diabetes, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Gestational diabetes is a strong risk factor for postpartum progression to glucose intolerance. | 28404514 |
| Glucose Intolerance (disease), Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | The American Diabetes Association(ADA) criteria applied for definition of postpartum glucose intolerance (pre-diabetes or diabetes) . | 28404514 |
| Dyslipidemias | Deregulated Nutrient Sensing | This overlapped therapeutic lifestyle change method may serve as a cost-effective adjunct and ensure the continuity of high-quality health services for patients with dyslipidaemia. | 28404531 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). | 28405675 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | There is an increasing prevalence of hypertension and dyslipidemia due to globalization and adoption of westernized dietary habits in India. | 28405988 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Nutritional strategies for reducing salt intake, saturated fat and balancing energy nutrients should be urgently applied in Indian hypertensive and dyslipidemia patients. | 28405988 |
| Hyperglycemia, Prediabetes syndrome | Deregulated Nutrient Sensing | The levels of kallistatin are higher in individuals with prediabetes, but are similar in subjects with and without insulin resistance, which indicates that the main factor for its increased levels may be hyperglycemia and not insulin sensitivity state. | 28406338 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Fasting triglycerides as a predictor of incident diabetes, insulin resistance and b-cell function in a Canadian First Nation. | 28406758 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The purpose of this study was to test for an association between fasting serum triglycerides and incident diabetes, changes in insulin resistance and changes in b-cell function in a Manitoba First Nation cohort. | 28406758 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Fasting triglycerides may be useful as a clinical predictor of insulin resistance and diabetes development among First Nations populations. | 28406758 |
| Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | The Effects of Omega-3 Fatty Acids and Vitamin E Co-Supplementation on Indices of Insulin Resistance and Hormonal Parameters in Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. | 28407657 |
| Prostate Cancer Outcomes Study, Polycystic Ovary Syndrome | Deregulated Nutrient Sensing | This study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in women with polycystic ovary syndrome (PCOS). | 28407657 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PCOS women significantly improved indices of insulin resistance, total and free testosterone. | 28407657 |
| Dyslipidemias | Deregulated Nutrient Sensing | Among those who were CCAA positive, there was a significant increased prevalence of dyslipidemia with age. | 28407989 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The results of this study might suggest that prescribers and patients with diabetes may be reluctant to initiate statin therapy for primary prevention without a concurrent diagnosis of dyslipidemia. | 28408169 |
| Communicable Diseases, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | BACKGROUND Chronic hepatitis C virus (HCV) infection is associated with increased insulin resistance and risk of type 2 diabetes. | 28413215 |
| Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | In the presence of cardiovascular disease, these age-associated alterations are accelerated, contributing in the appearance or the progression of cardiovascular disease, such as high blood pressure, dyslipidemia, smoking and diabetes. | 28413991 |
| HIV-1 Infection Pathway, Dyslipidemias | Deregulated Nutrient Sensing | Pitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial. | 28416195 |
| Left-Sided Heart Failure, Cerebrovascular accident, Osage language | Deregulated Nutrient Sensing | The new SLEEP Inventory (Sex, Left heart failure, ESS, Enlarged neck, weight [in Pounds], Insulin resistance/diabetes, and National Institutes of Health Stroke Scale) performed modestly better than other instruments in identifying patients with OSA, showing reasonable discrimination in the development (c-statistic .732) and validation (c-statistic .731) study populations, and having the highest negative predictive value of all in struments. | 28416405 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In T2D, NAFLD was associated with several markers of insulin resistance. | 28417532 |
| Increased insulin level, Hypoinsulinaemia (disorder) | Deregulated Nutrient Sensing | Furthermore, Jinlida alleviated insulin resistance with hyperinsulinemia and promoted insulin secretion with hypoinsulinemia. | 28418191 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The non-negligible prevalence of MS among HIV-infected patients under cART requires a careful and periodic monitoring of its components, with particular attention to dyslipidemia and hypertension. | 28420298 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Insulin resistance was observed in 146 (47.1%) children; the frequencies of dyslipidemia and hypertension were 31% and 19.4%, respectively. | 28421785 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Vitamin D deficiency could contribute to the morbidities associated with childhood obesity, such as insulin resistance or diabetes mellitus, increased cardiovascular/cardiometabolic risks, atherogenic dyslipidemia, and hypertension. | 28421785 |
| Dyslipidemias | Deregulated Nutrient Sensing | The mean atherogenic dyslipidemia ratio was higher in the deficient group (p = 0.049). | 28421785 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | HOMA of insulin resistance (IR) scores and disposition index 30 minutes after glucose load (DI30) were increased in early-onset diabetes participants. | 28422176 |
| Failure, Diabetes Mellitus | Deregulated Nutrient Sensing | In conclusion, patients diagnosed with diabetes at a younger age are characterized by a similar cardiovascular risk profile with increased insulin resistance and more severe beta cell failure than patients diagnosed at a later age. | 28422176 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum resistin positively correlates with serum lipids, but not with insulin resistance, in first-degree relatives of type-2 diabetes patients: an observational study in China. | 28422857 |
| Kidney Diseases, diabetic | Deregulated Nutrient Sensing | Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice. | 28424160 |
| SIRT1 gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3a than nondiabetic kidneys. | 28424160 |
| Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Our results demonstrate that hnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes. | 28424160 |
| deficiency aspects | Deregulated Nutrient Sensing | GNE deficiency may affect levels of UDP-GlcNAc, a key metabolite in the nutrient-sensing hexosamine biosynthetic pathway, but this modest effect did not fully account for the change in N-linked glycan structure. | 28424265 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of hypertension(62.5 vs 16.9%) and dyslipidemia(49.5 vs 9.7%) were more prevalent in patients with type 2 diabetes compared to non-diabetic cases. | 28425463 |
| Hypertension, CTCAE, Dyslipidemias, diabetic | Deregulated Nutrient Sensing | We also confirmed that the prevalence of hypertension and dyslipidemia are 3.7-fold and 5.1-fold higher, respectively, in diabetic patients than in non-diabetic adults. | 28425463 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The control group patients were referred by an endocrinologist to be tested for NAFLD; most of these patients had diabetes, hypertension, or dyslipidemia. | 28426815 |
| Obesity, Visceral, Prehypertension, Dyslipidemias, Diabetes Mellitus, Hyperuricemia, Renal Insufficiency | Deregulated Nutrient Sensing | Prevalences of prehypertension, hyperuricemia, visceral obesity and dyslipidaemia are apparent in very elderly women, while diabetes mellitus, renal dysfunction are common in very elderly men. | 28428538 |
| Acute Coronary Syndrome | Deregulated Nutrient Sensing | Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis. | 28430816 |
| GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104). | 28430816 |
| Acute Coronary Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Low-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial. | 28430910 |
| Dyslipidemias, GDC AJCC Clinical Stage Terminology | Deregulated Nutrient Sensing | Although intensive lowering with standard pitavastatin plus ezetimibe showed no more cardiovascular benefit than standard pitavastatin monotherapy in ACS patients with dyslipidaemia, statin plus ezetimibe may be more effective than statin monotherapy in patients with higher cholesterol absorption; further confirmation is needed. | 28430910 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | The same result was also obtained after adjustment for cardiovascular risk factors including age, dyslipidemia, diabetes mellitus and hypertension (p < 0.05). | 28431391 |
| Hyperglycemia, Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | From 1999 to 2010, dyslipidemia declined and abdominal obesity and hyperglycemia increased among individuals with prior MI. | 28431619 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Homozygous familial hypercholesterolaemia (HoFH) is a rare form of inherited dyslipidemia resistant to conventional cholesterol-lowering medications so that lipoprotein apheresis (LA) is usually required. | 28432645 |
| Inflammation | Deregulated Nutrient Sensing | While BM-MNC telomere attrition was not related with alterations in TERT, TRF1/2 and Sirt1 expression, IFNy levels were associated with p21Cip1/p16lnk4A upregulation, suggesting a link between inflammation and cellular senescence. | 28434530 |
| Dyslipidemias | Deregulated Nutrient Sensing | Omega-3 Fatty Acid Supplementation is Associated With Oxidative Stress and Dyslipidemia, but Does not Contribute to Better Lipid and Oxidative Status on Hemodialysis Patients. | 28434760 |
| HD Term Type, Dyslipidemias | Deregulated Nutrient Sensing | Although the n-3 PUFA supplementation was associated with lower concentrations of isoprostane and advanced oxidation protein product and higher HDL levels, it was not sufficient for the improvement of highly prevalent risk factors, such as OS and dyslipidemia in HD patients. | 28434760 |
| Glucose Intolerance (disease), Prediabetes syndrome, Diego blood group system | Deregulated Nutrient Sensing | Our results suggest that reduction of DI promptly reflects the alteration of early glucose intolerance in Japanese population presenting with prediabetes. | 28436739 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Branched chain amino acids (BCAA) may be involved in the pathogenesis of insulin resistance and are associated with type 2 diabetes mellitus (T2DM) development. | 28437198 |
| Dyslipidemias, "cytidylyl-3-5-guanosine | Deregulated Nutrient Sensing | This CPG is a practical tool that endocrinologists, other health care professionals, health-related organizations, and regulatory bodies can use to reduce the risks and consequences of dyslipidemia. | 28437620 |
| Hypercholesterolemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Special consideration is given to individuals with diabetes, familial hypercholesterolemia, women, and youth with dyslipidemia. | 28437620 |
| Inflammation | Deregulated Nutrient Sensing | 25(OH)D Levels in Relation to Gender, Overweight, Insulin Resistance, and Inflammation in a Cross-Sectional Cohort of Northern Italian Workers: Evidence in Support of Preventive Health Care Programs. | 28443804 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Over three-quarters of the entire group had dyslipidemia and 18.3% had hypertension, but only 3.0% had diabetes. | 28444007 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Additionally, high rates of hypertension and dyslipidemia were found, but a low rate of diabetes mellitus. | 28444007 |
| Albuminuria, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Additionally, the SIRT1 gene collaborates with the p300 gene and participates in promoting albuminuria in type 2 diabetes mellitus patients. | 28444663 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Diagnostic accuracy of serum alanine aminotransferase as biomarker for nonalcoholic fatty liver disease and insulin resistance in healthy subjects, using 3T MR spectroscopy. | 28445310 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer. | 28446188 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The clopidogrel group had a greater proportion of males and a higher rate of comorbidities, such as diabetes mellitus and dyslipidemia, than the control group. | 28451807 |
| Cardiovascular morbidity, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is reported in 27 - 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity. | 28454530 |
| Dyslipidemias | Deregulated Nutrient Sensing | The overall prevalence of dyslipidemia was 6.4% in the population-based cohort and 28.0% in the cohort with overweight/obesity. | 28454530 |
| Dyslipidemias | Deregulated Nutrient Sensing | The odds ratio for exhibiting dyslipidemia in the cohort with overweight/obesity compared with the population-based cohort was 6.2 (95% CI: 4.9 - 8.1, P < 2*10-16). | 28454530 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Children and adolescents with obesity have increased concentrations of circulating lipids and exhibit an increased prevalence of dyslipidemia. | 28454530 |
| Hemorrhage, Lung Injury | Deregulated Nutrient Sensing | Impaired AMPK Activity Drives Age-Associated Acute Lung Injury after Hemorrhage. | 28459384 |
| Thrombosis, Dyslipidemias, Malignant Neoplasms | Deregulated Nutrient Sensing | Dyslipidemia, prolonged immobilization, deep vein thrombosis, post-operative state, malignancy and post-partum period were the commonly reported risk factors. | 28460762 |
| Dyslipidemias | Deregulated Nutrient Sensing | Prevalence of dyslipidemia was high in this cohort of patients studied although the exact association of it in APE could not be determined. | 28460762 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Family history of CAD was in 50%, diabetes 44%, hypertension 49%, history of dyslipidemia 11%, smoking/tobacco use 39%, and sedentary habits in 20%. | 28460769 |
| Dyslipidemias, Myocardial Ischemia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Higher proportions of dyslipidemia (85.7%), hypertension (72.8%), and ischemic heart disease (IHD) (73.2%) were associated with urban residency (P<0.01). | 28461753 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | No association was found with obesity and dyslipidemia. | 28462541 |
| Inflammation, Dyslipidemias, Dental Plaque, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Ameliorating dyslipidemia in type 2 diabetic patients by femoropopliteal artery plaque resection under acute inflammation response. | 28462578 |
| Virus Diseases, HIV | Deregulated Nutrient Sensing | Insulin Resistance(IR) is increasing in Africans as well as among the Human Immunodeficiency Virus(HIV) infected population for several reasons which include the viral infection itself and the use of Highly active antiretroviral therapy (HAART). | 28462827 |
| Obesity | Deregulated Nutrient Sensing | Arterial stiffening, insulin resistance and acanthosis nigricans in a community sample of adolescents with obesity. | 28465605 |
| Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE, Overweight, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Obesity and overweight, diabetes, hypertension, and dyslipidemia are major risk factors for CKD. | 28467510 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Our findings warrant further research into the consequences of the metabolic effects of light for the diagnosis and prevention of hyperglycemia and dyslipidemia. | 28470119 |
| Lipolysis | Deregulated Nutrient Sensing | A greater proportion of ERa/ERb protein in the nuclear fraction of SAT at baseline (placebo day) was associated with greater reduction in SAT insulin resistance (i.e., better suppression of lipolysis, EC50) in response to E2 (r = -0.431, p<0.05). | 28472101 |
| Helminthiasis | Deregulated Nutrient Sensing | Emerging evidence suggests that helminth infections are associated with lower insulin resistance (IR). | 28472383 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Serum RBP4 and CKD: Association with insulin resistance and lipids. | 28473187 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Serum RBP4 is new adipokine and it has been related to insulin resistance and diabetes risk in animal and clinical studies. | 28473187 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia among parents was associated with 1.98 higher odds of dyslipidemia among youth (95% CI, 1.37-2.87). | 28476328 |
| Dyslipidemias | Deregulated Nutrient Sensing | Long-term treatment with anacetrapib 100 mg substantially reduced LDL-C, increased HDL-C and was well tolerated in Japanese patients with dyslipidemia (ClinicalTrials.gov number NCT01760460). | 28478132 |
| Dyslipidemias, Coronary Artery Disease, Diabetes Mellitus | Deregulated Nutrient Sensing | Coronary artery disease (P = 0.049), dyslipidemia (P < 0.001), diabetes (P = 0.047), and history of multiple prior infrainguinal procedures (P = 0.029) were associated with increased complications following groin wound reconstruction. | 28478163 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The most frequent comorbidities were hypertension (70%), dyslipidemia (51%), diabetes (24%) and obesity (23%). | 28478208 |
| Diastolic blood pressure | Deregulated Nutrient Sensing | BMI was significantly associated with systolic and diastolic blood pressure and insulin resistance. | 28478437 |
| Postmenopausal state | Deregulated Nutrient Sensing | Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk. | 28478612 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | TLR3 is implicated in insulin resistance and type 2 diabetes mellitus (T2DM). | 28479387 |
| Federated States of Micronesia | Deregulated Nutrient Sensing | When compared to FM, SAT and VAT had the strongest association with insulin resistance in adults. | 28481336 |
| Proteinuria, Hyperglycemia, Dyslipidemias, Hyalinosis, Systemic, Hypertransaminasaemia, Hypertension, CTCAE, Fatigue | Deregulated Nutrient Sensing | Common side effects were hypertension, HFS, fatigue, transaminitis, hyperglycemia, dyslipidemia, and proteinuria which were quite manageable. | 28485355 |
| Migraine Disorders, Dyslipidemias | Deregulated Nutrient Sensing | Introduction Recent studies have explored the relationship between dyslipidemia and migraine in a cardiovascular context. | 28486852 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia and history of stroke were also significantly associated with an elevated risk for CA of cardiac origin. | 28487155 |
| Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Whereas CA of cardiac origin is predicted by history of cardiovascular disease, dyslipidemia and diabetes mellitus, the main risk factors for CA of non-cardiac origin are obesity and hypertension. | 28487155 |
| Inflammation | Deregulated Nutrient Sensing | Our data suggest that as dietary GL increases within the moderate range, there is no detectable change in markers of inflammation or insulin resistance, despite which there is a negative effect on body composition. | 28492492 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias | Deregulated Nutrient Sensing | Male patients comprised 66%, 30% were diabetics, 46% had dyslipidemia, 28% previously sustained a myocardial infarction, and 9.4% underwent prior cardiovascular surgery. | 28492786 |
| Carotid Stenosis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is a well-known risk factor for carotid stenosis progression, but triglycerides have attracted little attention. | 28495179 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Multivariable regression analysis showed that BMI was associated positively with insulin resistance and inversely with insulin sensitivity in type 2 diabetes mellitus group (all P<0.05). | 28496312 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Higher BMI was associated with increased insulin resistance and decreased insulin sensitivity in elderly Asian population with type 2 diabetes mellitus. | 28496312 |
| Endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance is associated with endothelial dysfunction and ensuing cardiovascular diseases in type 2 diabetes mellitus (T2DM) patients. | 28497367 |
| Atherosclerosis, diabetic | Deregulated Nutrient Sensing | Factors which enhance insulin resistance increase the risk for onset and progression of coronary atherosclerosis irrespective of a diabetic background. | 28497367 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Western blot analysis and confocal microscopy results indicated that overexpression of miR-138 or interference of Sirt1 expression could inhibit lung cancer cell autophagy activity possibly through AMPK-mTOR signaling pathway. | 28498463 |
| Neoplasm Metastasis, Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. | 28498463 |
| Carcinoma of lung | Deregulated Nutrient Sensing | The protein expression of the potential target gene Sirt1 in lung cancer cells were determined by western blot analysis. | 28498463 |
| Carcinoma of lung | Deregulated Nutrient Sensing | It may inhibit the proliferation, invasion and migration of lung cancer through downregulation of Sirt1 expression and activation of cell autophagy. | 28498463 |
| SLC25A20 gene, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Among patients with CAC, age, diabetes, hypertension and dyslipidemia were associated with an increasing CAC score in males and females, with diabetes being the strongest dichotomous risk factor (p<0.001 for both). | 28499962 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | To a lesser extent, hypertension and dyslipidemia were also associated in the high CAC quantiles and the low CAC quantiles respectively. | 28499962 |
| Prostate Cancer Outcomes Study, Dyslipidemias | Deregulated Nutrient Sensing | This supports prior findings that adiposity is a key driver of dyslipidaemia in PCOS and highlights the need for weight management through lifestyle interventions. | 28500248 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa Population Study and the Framingham Offspring Study. | 28502490 |
| Cerebrovascular, Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Effects of statin therapy on cerebrovascular and renal outcomes in patients with predialysis advanced chronic kidney disease and dyslipidemia. | 28502499 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Statins may reduce the all-cause mortality and reduced the risk of dialysis in patients with predialysis advanced CKD and dyslipidemia. | 28502499 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A total of 1022 Finnish adults diagnosed with CAD, diabetes, hypertension, or severe hereditary dyslipidemia completed an electronic questionnaire survey during a visit in 1 of the 84 community pharmacies participating in the study. | 28502506 |
| Dyslipidemias | Deregulated Nutrient Sensing | Thirty-four percent of the survey respondents were diagnosed with CAD or severe hereditary dyslipidemia and 82% were current or former statin users. | 28502506 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Relationship between noninvasive scores of nonalcoholic fatty liver disease and nuclear magnetic resonance lipoprotein abnormalities: A focus on atherogenic dyslipidemia. | 28502513 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hypertension was more prevalent among black patients, diabetes and obesity were more prevalent among female and black patients, dyslipidaemia was more prevalent among male and white patients, and comorbidities were more prevalent among older patients (all P < 0.001). | 28503912 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. | 28505362 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | Managing the challenging homozygous familial hypercholesterolemia patient: Academic insights and practical approaches for a severe dyslipidemia, a National Lipid Association Masters Summit. | 28506384 |
| Hypercholesterolemia, Dyslipidemias | Deregulated Nutrient Sensing | The following article represents material presented and discussed at a symposium hosted by the National Lipid Association hosted entitled "Managing the Challenging Homozygous Familial Hypercholesterolemia Patient-Academic Insights and Practical Approaches for a Severe Dyslipidemia" on November 7, 2015 in Orlando, FL. | 28506384 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The major types of dyslipidemia in Chinese population are hypertriglyceridemia and low HDL-C. | 28506386 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | In nonstatin users, the major types of dyslipidemia were hypertriglyceridemia combined with low HDL-C, isolated low HDL-C, and isolated hypertriglyceridemia, accounting for 21.60%, 19.70%, and 14.99%, respectively. | 28506386 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Thirty (60%) were current or ex-smokers, 4 (8%) had diabetes, 8 (16%) had hypertension and 26 (52%) had dyslipidaemia. | 28506456 |
| ARCN1 gene | Deregulated Nutrient Sensing | The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. | 28506610 |
| ARCN1 gene | Deregulated Nutrient Sensing | Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD. | 28506610 |
| ARCN1 gene | Deregulated Nutrient Sensing | s120S was decreased in the patients with COPD, potentially as reflected by the reduced SIRT1 within cells as a result of oxidative stress, and might be a potential biomarker for certain disease characteristics of COPD. | 28506610 |
| vascular inflammations, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice. | 28507343 |
| Non-alcoholic Fatty Liver Disease, Vascular System Injuries | Deregulated Nutrient Sensing | We aimed to determine whether TRAIL protects against insulin resistance, NAFLD and vascular injury. | 28507343 |
| vascular inflammations, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | These findings suggest that TRAIL protects against insulin resistance, NAFLD and vascular inflammation. | 28507343 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity. | 28508444 |
| Obesity | Deregulated Nutrient Sensing | The adipose tissue IL-18R/IL-18 expression is enhanced in obesity which associates with proinflammatory gene signature and insulin resistance in these individuals. | 28508444 |
| Hypertension, CTCAE, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Hypertension was reported for 60 patients (82%); dyslipidemia, for 56 (77%); obesity, for 37 (51%); and smoking, for 10 (14%). | 28508856 |
| Dyslipidemias, Dental Plaque, Disease of capillaries | Deregulated Nutrient Sensing | A multivariate regression analysis showed that the carotid plaque score, but not carotid IMT, was significantly associated with dyslipidemia (P = 0.03) and microangiopathy (P = 0.01). | 28508856 |
| Impaired cognition, Presenile dementia, Dyslipidemias, Diabetes Mellitus, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. | 28509343 |
| Colorectal Neoplasms, Obesity | Deregulated Nutrient Sensing | Obesity and insulin resistance are risk factors for colorectal neoplasms (CRN), but data regarding metabolic status, obesity, and CRN are lacking. | 28510711 |
| Inflammation, Heart failure, Anemia, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Furthermore, anemia, insulin resistance, inflammation, and poor glycemic control are independent risk factors for the development of heart failure among patients with chronic kidney disease. | 28515118 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Is bisphenol A exposure associated with the development of glucose intolerance and increased insulin resistance in Thais? | 28516806 |
| Dyslipidemias | Deregulated Nutrient Sensing | Multivariate logistic regression showed a history of dyslipidemia (odds ratio [OR] = 6.83, P = .008), and an SIR lower than the median (OR = 4.73, P = .014) were independently associated with presence of CMI(s) in ipsilateral hemisphere to an MCA-M1 stenosis. | 28522230 |
| Dyslipidemias | Deregulated Nutrient Sensing | Except for a history of dyslipidemia, the hemodynamic significance of the arterial stenosis may contribute to the presence of ipsilateral CMI(s) in these patients, which warrants further investigation in prospective, longitudinal studies. | 28522230 |
| Communicable Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | HCV infection was found to be associated with insulin resistance, a step towards type 2 diabetes mellitus (T2DM). | 28523926 |
| Metabolic Diseases, Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity in children is associated with early onset metabolic disorders such as dyslipidemia, high blood pressure and type 2 diabetes. | 28526006 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidaemia is a major contributor to the increased risk of cardiovascular disease (CVD) associated with type 2 diabetes (T2D). | 28526014 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | There is a need for increased implementation of guideline recommendations such as American College of Cardiology/American Heart Association for the management of dyslipidaemia in patients with T2D. | 28526014 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Deficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia. | 28526388 |
| Dyslipidemias | Deregulated Nutrient Sensing | Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. | 28526388 |
| Dyslipidemias | Deregulated Nutrient Sensing | Risk for incident dyslipidemia was determined for those without baseline dyslipidemia. | 28526388 |
| Dyslipidemias | Deregulated Nutrient Sensing | Those with deficient compared with optimal 25(OH)D had modestly increased risk for incident dyslipidemia in demographic-adjusted models (relative risk [RR], 1.19; 95% CI, 1.02-1.39), which was attenuated in fully adjusted models (RR, 1.12; 95% CI, 0.95-1.32). | 28526388 |
| Dyslipidemias, Borderline Personality Disorder, Diabetes Mellitus, Bronchopulmonary Dysplasia, Hypertension, CTCAE | Deregulated Nutrient Sensing | Previous studies suggested that patients with borderline personality disorder (BPD) had a higher prevalence of stroke-related risk factors, such as hypertension, dyslipidemia, and diabetes mellitus. | 28528281 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Medical record data for diabetes and dyslipidemia were obtained. | 28529225 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Obesity and a lipid rich diet may have contributed to the dyslipidemia observed in CP patients. | 28531465 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diabetes mellitus, hypertension and dyslipidemia were more common in TVD patients. | 28531788 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Hereafter, a new approach for treating insulin resistance and diabetes may be developed by new therapeutic potentials such as neutralization of Ab by anti-Ab antibodies. | 28534431 |
| Prostate Cancer Outcomes Study, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Cardiovascular Diseases | Deregulated Nutrient Sensing | We also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS. | 28535403 |
| Alzheimers Disease", Diabetes Mellitus, Non-Insulin-Dependent, Data types - Address | Deregulated Nutrient Sensing | Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. | 28538088 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The modifiable risk factors, other than current smoking habit (5.3%), were common: hypertension (83.8%), dyslipidaemia (85.9%) and diabetes mellitus (57.4%). | 28540395 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A majority of patients with hypertension (96.3%), dyslipidaemia (93.8%) and diabetes mellitus (78.5%) received medications for their conditions. | 28540395 |
| Rectal Carcinoma | Deregulated Nutrient Sensing | Rectal cancer surgery induced profound insulin resistance, affecting glucose and fatty acid metabolism. | 28541810 |
| IFNG wt Allele | Deregulated Nutrient Sensing | Our data suggest that IFG occurred in 30% of b TM children, perhaps due to insulin resistance secondary to iron overload. | 28544032 |
| Intellectual Disability, Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Type 2 diabetes and glucose intolerance in a population with intellectual disabilities: the STOP diabetes cross-sectional screening study. | 28544066 |
| diabetic | Deregulated Nutrient Sensing | Moreover, kallistatin administration attenuated STZ-induced aortic senescence, oxidative stress, and miR-34a and miR-21 synthesis, and increased SIRT1, eNOS, and catalase levels in diabetic mice. | 28544111 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Our results suggest that the components related to the metabolism of glucose and to high blood pressure appear early on and act as biomarkers for predicting MS, while the components related to obesity and dyslipidaemia, although essential for the development of MS, appear later. | 28545089 |
| Metabolic Diseases, Diabetes Mellitus, Non-Insulin-Dependent, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Particulate air pollution induced changes in cord plasma insulin levels during early life and might be a risk factor in the development of metabolic disease, such as glucose intolerance or type 2 diabetes, later in life. | 28545656 |
| Prostate Cancer Outcomes Study, Obesity, Abdominal, Dyslipidemias, Hyperandrogenism | Deregulated Nutrient Sensing | Our findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long-term health of women with PCOS. | 28546543 |
| Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Overconsumption of dietary sugars, fructose in particular, is linked to cardiovascular risk factors such as type 2 diabetes, obesity, dyslipidemia and nonalcoholic fatty liver disease. | 28548281 |
| Muscle damage, Inflammation, Overweight | Deregulated Nutrient Sensing | Muscle damage derived from overweight displayed by oxidative and endoplasmic reticulum (ER) stress induces inflammation and insulin resistance and forces the muscle to increase requirements from autophagy mechanisms. | 28549989 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Apomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer's Disease. | 28550243 |
| Data types - Address | Deregulated Nutrient Sensing | Thus, brain insulin resistance is considered an important therapeutic target in AD, and APO may provide improved neuronal insulin resistance. | 28550243 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Alzheimer's disease (AD) may have heterogeneous pathophysiological underpinnings, with risk factors including apolipoprotein rmvarep4 (APOE4) genotype and insulin resistance. | 28550261 |
| Inflammation, Intestines | Deregulated Nutrient Sensing | Mice with intestinal deletion of SIRT1 (SIRT1 iKO) had abnormal activation of Paneth cells starting at the age of 5-8 months, with increased activation of NF-kB, stress pathways, and spontaneous inflammation at 22-24 months of age, compared with control mice. | 28552621 |
| Colitis | Deregulated Nutrient Sensing | Moreover, SIRT1 iKO mice with defective gut microbiota developed more severe colitis than control mice. | 28552621 |
| Ulcerative Colitis | Deregulated Nutrient Sensing | Intestinal tissues from patients with ulcerative colitis expressed significantly lower levels of SIRT1 mRNA than controls. | 28552621 |
| Inflammation, Colitis | Deregulated Nutrient Sensing | Intestinal tissues from SIRT1 iKO mice given antibiotics, however, did not have signs of inflammation at 22-24 months of age, and did not develop more severe colitis than control mice at 4-6 months. | 28552621 |
| Gastrointestinal inflammation, Colitis | Deregulated Nutrient Sensing | In analyses of intestinal tissues, colitis induction, and gut microbiota in mice with intestinal epithelial disruption of SIRT1, we found this protein to prevent intestinal inflammation by regulating the gut microbiota. | 28552621 |
| CDISC Integrated Basic Data Structure Dataset | Deregulated Nutrient Sensing | Agents designed to activate SIRT1 might be developed as treatments for IBDs. | 28552621 |
| Osteolysis | Deregulated Nutrient Sensing | Various pathways in multiple cell types contribute to the pathogenesis of osteolysis, but the role of Sirtuin 1 (SIRT1), which can regulate inflammatory responses through its deacetylation, has never been investigated. | 28553103 |
| Failure, Osteolysis | Deregulated Nutrient Sensing | We hypothesized that the downregulation of SIRT1 in macrophages induced by metal nanoparticles was one of the reasons for osteolysis in THA failure. | 28553103 |
| Osteolysis | Deregulated Nutrient Sensing | Pharmacological activation of SIRT1 dramatically reduced the particle-induced expression of inflammatory cytokines in vitro and osteolysis in vivo. | 28553103 |
| Obesity | Deregulated Nutrient Sensing | Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people. | 28553648 |
| Nonalcoholic Steatohepatitis, Carotid Intima-Media Thickness, Atherosclerosis, Fibrosis Assessment, Diabetes Mellitus, Dental Plaque, Fatty Liver Disease | Deregulated Nutrient Sensing | We collected anthropometric, clinical, and biochemical data, as well as information on carotid atherosclerosis (artery intima-media thickness and plaque), liver histology (nonalcoholic steatohepatitis [NASH] and fibrosis), insulin resistance, and diabetes. | 28554682 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Our study suggests that OHT is associated with insulin resistance syndrome and onset of sustained arterial hypertension in normotensive, newly diagnosed diabetics. | 28554697 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Polyunsaturated fatty acids (PUFA) correlate with risk of dyslipidemia and cardiovascular diseases. | 28555039 |
| Sarcopenia | Deregulated Nutrient Sensing | We tested the hypothesis that lifelong inhibition of the classical NFkB pathway would protect against aging-related sarcopenia and insulin resistance. | 28556540 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | High calf circumference is significantly associated with elevated prevalence of NAFLD and increasing insulin resistance. | 28558676 |
| Obesity | Deregulated Nutrient Sensing | It appears that orally administered H2 as a blend of hydrogen-generating minerals might be a beneficial agent in the management of body composition and insulin resistance in obesity. | 28560519 |
| Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident | Deregulated Nutrient Sensing | High blood pressure, low socioeconomic status, dyslipidemia, diabetes, and family history of stroke were observed to be statistically significant risk factors for IS. | 28562233 |
| Hypoglycemia | Deregulated Nutrient Sensing | She subsequently developed signs of insulin resistance and severe hypoglycemia, which was found to be due to insulin-receptor autoantibodies. | 28562254 |
| Metabolic Diseases, Increased insulin level, Hypoglycemia, Diabetes Mellitus | Deregulated Nutrient Sensing | This condition, known as type B insulin resistance, is a rare, heterogeneous metabolic disease that may feature hypoglycemia in the setting of extreme insulin resistance and hyperinsulinemia and, in this case, masqueraded as type 1 diabetes mellitus. | 28562254 |
| Diabetes Mellitus, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. | 28565926 |
| Hypertension, CTCAE, Demographics Domain, Dyslipidemias | Deregulated Nutrient Sensing | Chi-square test was performed to compare gender, smoker rate, prevalence of DM, hypertension and dyslipidemia and edentulous rate. | 28567552 |
| helium, Dyslipidemias | Deregulated Nutrient Sensing | More patients with HE had dyslipidemia than those with HU (58% vs. 38%). | 28569557 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | Acute BP elevations are associated with hyperglycemia, dyslipidemia, and higher potassium and creatinine levels and lower renal function. | 28569557 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Importantly, it suggests that NASH may be one of the early complications of T2DM due to its pathophysiological correlation with insulin resistance. | 28570615 |
| Dyslipidemias, Psoriasis, Metabolic Syndrome X | Deregulated Nutrient Sensing | Psoriasis is associated with dyslipidemia and metabolic syndrome, and has been linked to an increased cardiovascular risk. | 28573499 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. | 28575103 |
| Inflammation | Deregulated Nutrient Sensing | Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. | 28575103 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance. | 28575103 |
| Cessation of life, Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Dyslipidemia is one of the major risk factors for atherosclerosis and the main cause of death in the developing and developed countries. | 28576562 |
| Parkinson Disease | Deregulated Nutrient Sensing | SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease. | 28578695 |
| Parkinson Disease, Neurodegenerative Disorders | Deregulated Nutrient Sensing | SIRT1, the best studied mammalian SIRT is involved in many physiological and pathological processes and changes in SIRT1 have been implicated in neurodegenerative disorders, with SIRT1 having a suggested protective role in Parkinson's disease. | 28578695 |
| Cessation of life | Deregulated Nutrient Sensing | Over-expression of SIRT1 protected SH-SY5Y cells from toxin induced cell death and the protection conferred by SIRT1 was partially independent of its deacetylase activity, which was associated with the repression of NF-kB and cPARP expression. | 28578695 |
| Parkinson Disease, Lewy Bodies, "Alzheimers Disease", Presenile dementia | Deregulated Nutrient Sensing | In post-mortem brain tissue obtained from patients with Parkinson's disease, Parkinson's disease with dementia, dementia with Lewy bodies and Alzheimer's disease, the activity of SIRT1 was observed to be down-regulated. | 28578695 |
| Neurodegenerative Disorders | Deregulated Nutrient Sensing | These findings suggests a negative effect of oxidative stress in neurodegenerative disorders and possibly explain the reduced activity of SIRT1 in neurodegenerative disorders. | 28578695 |
| Canada, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The insulin resistance (IR) itself is bidirectionally associated with increased risk of type 2 diabetes mellitus (T2DM) and CAN is a predisposing factor. | 28581270 |
| Dyslipidemias, Premature coronary artery atherosclerosis | Deregulated Nutrient Sensing | In this group, prevalence of dyslipidemia, smoking and family history of premature coronary artery disease (CAD) was higher, while the other classical risk factors were lower when compared to the old patients. | 28585049 |
| Adrenal Gland Neoplasms | Deregulated Nutrient Sensing | There was no significant correlation between fasting glucose, insulin resistance indices, and adrenal tumour size or degree of cortisol secretion. | 28585681 |
| Degenerative polyarthritis | Deregulated Nutrient Sensing | Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. | 28586000 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Nocturnal but not Diurnal Hypertension Is Associated to Insulin Resistance Markers in Subjects With Normal or Mildly Elevated Office Blood Pressure. | 28586418 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | There were no significant differences among the levels of insulin resistance markers between individuals with or without diurnal hypertension. | 28586418 |
| Hypertensive (finding), Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Nocturnal but not diurnal hypertension was related to higher levels of 3 insulin resistance markers in normotensive and untreated mildly hypertensive adults; this relationship seems partially independent of obesity. | 28586418 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | These ethnic groups showed increased prevalence of dyslipidemia, obesity, and much greater abnormalities asunique risk. | 28586605 |
| Dyslipidemias, Hypertension, CTCAE, Sarcopenia, Diabetes Mellitus | Deregulated Nutrient Sensing | High-risk drinking is also closely related to diabetes, hypertension, and dyslipidemia, which are modifiable risk factors for sarcopenia. | 28590346 |
| palladium, Communicable Diseases, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | HbA1c, dyslipidemia, hypertension, PD and duration of the procedure were predictive of infection complications (p < 0.05). | 28590832 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | A low insulinogenic index (IGI) level, but not insulin resistance, was a significant determinant of developing diabetes in subjects who had baseline KDS < 5. | 28591043 |
| Dyslipidemias | Deregulated Nutrient Sensing | The sample consisted of 60,202 individuals who reported a medical diagnosis of dyslipidemia. | 28591319 |
| Cessation of life, Dyslipidemias, Coronary heart disease | Deregulated Nutrient Sensing | The importance of dyslipidemia awareness in the present Brazilian epidemiological context must be emphasized to guide actions to control and prevent coronary heart disease, the leading cause of death in Brazil and worldwide. | 28591319 |
| Tuberous Sclerosis | Deregulated Nutrient Sensing | Here we showed that BRSK2, a serine/threonine-protein kinase of AMPK family, was induced by nutrient deprivation in PDAC cells and suppressed mTORC1 activity via phosphorylation of tuberous sclerosis complex 2 (TSC2). | 28591720 |
| ARCN1 gene, Chronic Obstructive Airway Disease, Sleep Apnea Syndromes | Deregulated Nutrient Sensing | In multivariate analysis, SteatoTest and FibroTest were significantly associated with sex, body mass index (BMI), untreated sleep apnoea and insulin resistance, and, in addition, COPD Global Initiative for Chronic Obstructive Lung Disease stage for SteatoTest. | 28596431 |
| Ischemic stroke | Deregulated Nutrient Sensing | IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance. | 28596451 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | TAK-228 (formerly MLN0128), an investigational dual TORC1/2 inhibitor plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies. | 28601972 |
| Malignant Neoplasms | Deregulated Nutrient Sensing | This phase I trial evaluated the safety, pharmacokinetic profile, and antitumor activity of investigational oral TORC1/2 inhibitor TAK-228 plus paclitaxel, with/without trastuzumab, in patients with advanced solid malignancies. | 28601972 |
| Glucose Intolerance (disease), Data types - Address | Deregulated Nutrient Sensing | Our findings suggest that elevated GA/HbA1c ratio-but not HbA1c, GA, or 1,5-AG level-is significantly associated with the risk of AD in subjects both with and without glucose intolerance. | 28605542 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Impaired nutrient sensing and dysregulated glucose homeostasis are common in diabetes. | 28606928 |
| Prediabetes syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Blood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia. | 28609607 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Prediabetes often occurs together with dyslipidaemia, which is paradoxically treated with statins predisposing to type 2 diabetes mellitus. | 28609607 |
| Prediabetes syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Blood cell gene expression profiles differ significantly between prediabetic subjects with and without dyslipidaemia. | 28609607 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria. | 28610915 |
| Dyslipidemias | Deregulated Nutrient Sensing | Homocysteine level is worsened by increasing insulin resistance, dyslipidaemia and poor glucose control. | 28610915 |
| Pancreatitis, Dyslipidemias, Cardiomyopathies, Atherosclerosis | Deregulated Nutrient Sensing | Other organs are also affected with pathological changes, such as pancreatitis, cardiomyopathies, dyslipidemias and atherosclerosis. | 28614536 |
| Obesity | Deregulated Nutrient Sensing | The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country. | 28617856 |
| Obesity | Deregulated Nutrient Sensing | VDR BsmI polymorphism was significantly associated with vitamin D deficiency and insulin resistance, but not with obesity in this population. | 28617856 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a major modifiable risk factor for cardiovascular disease. | 28620070 |
| Hypertension, CTCAE, Ischemic stroke, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension (67%), dyslipidemia (45%), and ischaemic stroke (32%) were the most common co-morbid conditions in the hospital cohort of patients. | 28622547 |
| Dyslipidemias, Hypertension, CTCAE, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension, diabetes, dyslipidaemia, and obesity, but not smoking were strong predictors of PAD. | 28623035 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prevalence and treatment of atherogenic dyslipidemia in the primary prevention of cardiovascular disease in Europe: EURIKA, a cross-sectional observational study. | 28623902 |
| Dyslipidemias | Deregulated Nutrient Sensing | Atherogenic dyslipidemia is associated with poor cardiovascular outcomes, yet markers of this condition are often ignored in clinical practice. | 28623902 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | A considerable proportion of patients with at least one major cardiovascular risk factor in the primary cardiovascular disease prevention setting have markers of atherogenic dyslipidemia. | 28623902 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | The final sample included 49 sedentary men and women, who were non-smokers, with dyslipidaemia, overweight, and type1 obesity. | 28625710 |
| Lupus Erythematosus, Systemic | Deregulated Nutrient Sensing | High mTORC1 activation was noted in CD19+ B cells of patients with SLE and correlated with plasmablast differentiation and disease activity. | 28626065 |
| Diabetes Mellitus, Insulin-Dependent | Deregulated Nutrient Sensing | The aim of our study was to develop novel, accurate machine learning-based methods of insulin resistance estimation in children with type 1 diabetes. | 28626972 |
| Dyslipidemias, Units Of Measure - Siemens | Deregulated Nutrient Sensing | The MAO and MADO groups showed higher blood pressure, atherogenic dyslipidemia, insulin resistance and inflammatory profile than that of MHO subjects. | 28630460 |
| Dyslipidemias | Deregulated Nutrient Sensing | Some simple anthropometric measurements such as body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), may link to increased risk of dyslipidemia. | 28632766 |
| Hypercholesterolemia, CD55 gene, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The overall prevalence of high TC, high LDL-C, low HDL-C, hypercholesterolemia, hypertriglyceridemia and dyslipidemia were 15.68%, 27.98%, 20.12%, 44.01%, 21.98% and 49.06% respectively. | 28632766 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | Multiple logistic regressions showed only BMI (per quartile increment) increased risks for prevalent high LDL-C, low HDL-C, hypercholesterolemia, hypertriglyceridemia, and dyslipidemia. | 28632766 |
| Hypercholesterolemia, Dyslipidemias, Metabolic Syndrome X | Deregulated Nutrient Sensing | Regardless of sex, age and prevalent metabolic syndrome, increasing BMI was persistently independent risk factor for having low HDL-C, hypercholesterolemia and dyslipidemia, however was not associated with high TC. | 28632766 |
| Dyslipidemias | Deregulated Nutrient Sensing | In non-obese Chinese population aged more than 40 years, increasing BMI may better identify the prevalent dyslipidemia than other anthropometric measurements. | 28632766 |
| HD Term Type | Deregulated Nutrient Sensing | Recent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD. | 28632780 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Lipoprotein(a)-activated immunity, insulin resistance and new-onset diabetes. | 28633585 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We aimed to determine in nondiabetic people the relationship of serum [Lp](a) with insulin resistance and new-onset diabetes (NOD). | 28633585 |
| Inflammation, Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is attributed to a "multi-hits hypothesis" involving insulin resistance, oxidative stress and inflammation. | 28637594 |
| Inflammation | Deregulated Nutrient Sensing | The underlying mechanisms may be partly attributed to the interactions between insulin resistance, oxidative stress, inflammation, and DPP4. | 28637594 |
| Glucose Intolerance (disease), Sarcopenia | Deregulated Nutrient Sensing | Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid. | 28638045 |
| Glucose Intolerance (disease), Sarcopenia | Deregulated Nutrient Sensing | In these ways, muscle mitochondrial activation with ALA is suggested to be useful for the treatment of sarcopenia and glucose intolerance. | 28638045 |
| Cardiac complication, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Whether regulating apoC-III metabolism may be an important new therapeutic approach to managing dyslipidemia and microvascular complications in T2D remains to be proven in future mechanistic and clinical studies. | 28641786 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Multiple regression analysis indicated that cIABPDsys was associated with the Gensini score, independently of age, gender, smoking, diabetes, hypertension and dyslipidemia (B = 0.031, p < 0.001). | 28645074 |
| Calcification of coronary artery | Deregulated Nutrient Sensing | Relationship between simple markers of insulin resistance and coronary artery calcification. | 28652190 |
| Coronary Arteriosclerosis, Congenital Abnormality | Deregulated Nutrient Sensing | Insulin resistance in apparently healthy persons is associated with a cluster of metabolic abnormalities that promote coronary atherosclerosis. | 28652190 |
| TG gene, SLC25A20 gene, Prediabetes syndrome | Deregulated Nutrient Sensing | We hypothesized that combining 2 simple markers of insulin resistance, prediabetes (PreDM) and triglyceride (TG) concentration >=150 mg/dL, would identify apparently healthy persons with adverse cardiometabolic risk profiles and increased coronary artery calcium (CAC) compared with those with neither or only 1 abnormality. | 28652190 |
| TG gene | Deregulated Nutrient Sensing | The presence of 2 markers of insulin resistance, PreDM and TG concentration >=150 mg/dL, is associated with increased cardiometabolic risk and detectable CAC within a population of apparently healthy individuals. | 28652190 |
| Impaired T cell function, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes mellitus (T2DM) is caused by insulin resistance and b cell dysfunction. | 28654680 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Association of matrix g-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study. | 28654853 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | There is at present the dearth of information on the possible contribution of insulin resistance to scores obtained from mortality risk estimation in patients with type 2 diabetes mellitus (T2DM). | 28656934 |
| Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Even if PSS are present, control of blood ammonia levels by BRTO alone may be difficult in patients with glucose intolerance. | 28657848 |
| Obesity | Deregulated Nutrient Sensing | Pre-sarcopenia is associated with renal hyperfiltration independent of obesity or insulin resistance: Nationwide Surveys (KNHANES 2008-2011). | 28658107 |
| Obesity | Deregulated Nutrient Sensing | Multiple logistic regression analyses also demonstrated this independent association between pre-sarcopenia and renal hyperfiltration, following adjustment for confounding factors such as insulin resistance and obesity (OR = 1.84, 95% CI = 1.57-2.15, P < .001).In the general population of healthy individuals, pre-sarcopenia might be associated with renal hyperfiltration independent of obesity or insulin resistance. | 28658107 |
| Hyperglycemia, Impaired | Deregulated Nutrient Sensing | It is characterized by hyperglycemia, insulin resistance (IR), and relative impairment in insulin secretion. | 28658166 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of the distinct CVRFs was 35% for systemic hypertension, 17.5% for dyslipidemia, 17.5% for smoking, and 10% for type 2 diabetes mellitus. | 28662815 |
| Memory impairment | Deregulated Nutrient Sensing | We have previously shown that Ludwigia octovalvis extract (LOE) can significantly extend lifespan and improve age-related memory deficits in Drosophila melanogaster through activating AMP-activated protein kinase (AMPK). | 28666833 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Since AMPK has become a critical target for treating diabetes, we herein investigate the anti-hyperglycemic potential of LOE. | 28666833 |
| Hypertension, CTCAE, Atherosclerosis, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The adjusted odds ratios (aOR) for coronary atherosclerosis, hypertension, dyslipidaemia and diabetes were 7.97, 2.09, 2.48 and 1.51, respectively. | 28667203 |
| palladium, Dyslipidemias | Deregulated Nutrient Sensing | The association of dyslipidemia with mortality has not been fully evaluated in patients on peritoneal dialysis (PD). | 28669685 |
| Spinal Cord Injuries | Deregulated Nutrient Sensing | Cutaneous microvascular perfusion responses to insulin iontophoresis are differentially affected by insulin resistance after spinal cord injury. | 28671307 |
| Spinal Cord Injuries | Deregulated Nutrient Sensing | What impact does insulin resistance have on cutaneous perfusion responses to insulin iontophoresis in vascular beds with markedly reduced or functionally ablated sympathetic nervous system vasomotor function resulting from spinal cord injury? | 28671307 |
| Spinal Cord Injuries | Deregulated Nutrient Sensing | Persons with spinal cord injury have sublesional microvascular endothelial dysfunction, as indicated by a blunted cutaneous perfusion response to acetylcholine iontophoresis, and the presence of insulin resistance has a further confounding effect on endothelium-mediated changes to cutaneous perfusion in the lower extremities. | 28671307 |
| Stanford Cancer Institute | Deregulated Nutrient Sensing | The effects of insulin resistance (IR) on sublesional cutaneous perfusion responses to insulin provocation have yet to be described in persons with SCI. | 28671307 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Associations of lipid parameters with insulin resistance and diabetes: A population-based study. | 28673690 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The present study aims to investigate associations of routine lipid profiles with insulin resistance and diabetes, respectively. | 28673690 |
| TG gene, Diabetes Mellitus | Deregulated Nutrient Sensing | Participants with insulin resistance or diabetes presented with significantly higher triglycerides (TG), Non-high-density lipoprotein cholesterol (Non-HDL-C), Non-HDL-C/HDL-C, TG/HDL-C and lower HDL-C when compared with control subjects (all P < 0.0001). | 28673690 |
| TG gene, Diabetes Mellitus | Deregulated Nutrient Sensing | In logistic regression analysis, subjects were more likely to have prevalent insulin resistance and diabetes with the elevated quartiles of TG, Non-HDL-C, Non-HDL-C/HDL-C and TG/HDL-C (all P < 0.05). | 28673690 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | TG/HDL-C ratio, compare with other lipid parameters, have shown the strongest correlation with increased odds of insulin resistance and diabetes. | 28673690 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our study suggests a discordant association of lipid parameters with blood glucose level and TG/HDL-C is a better marker for evaluating insulin resistance and diabetes in Chinese population when compared with other routine lipid measures. | 28673690 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | A dramatic gap exists between the clinical practice and guidelines for the dyslipidemia control in patients with diabetes. | 28673690 |
| Dyslipidemias | Deregulated Nutrient Sensing | Interventions in youth that address poor glycemic control and dyslipidemia may prevent or delay debilitating neuropathic complications. | 28674076 |
| diabetic | Deregulated Nutrient Sensing | Our data showed that Plasma CTRP1 was higher and negative correlation with insulin resistance in diabetic subjects (r = -0.283, p = 0.018). | 28674284 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Putting insulin resistance into context by dietary reversal of type 2 diabetes. | 28675193 |
| Structure of beta Cell of islet, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | It has long been assumed that type 2 diabetes is caused by the combined effects of insulin resistance and loss of pancreatic islet beta cells. | 28675193 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS. | 28675895 |
| Cessation of life, Liver carcinoma | Deregulated Nutrient Sensing | Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells. | 28676953 |
| FAM126A gene | Deregulated Nutrient Sensing | Interestingly, gallotannin attenuated the expression of SIRT1 and mTOR and activated phosphorylation of AMPK in two HCC cells. | 28676953 |
| FAM126A gene | Deregulated Nutrient Sensing | Furthermore, AMPK activator AICAR significantly enhanced SA-b-gal activity and antiproliferation induced by gallotannin, while AMPK inhibitor compound C did not in two HCC cells. | 28676953 |
| Cessation of life, FAM126A gene | Deregulated Nutrient Sensing | Overall, these findings highlight evidence that regulation of SIRT1/AMPK is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in HCC cells. | 28676953 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients. | 28677090 |
| Diabetes Mellitus, Non-Insulin-Dependent, Chronic Kidney Diseases | Deregulated Nutrient Sensing | The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD. | 28677090 |
| Injury of liver, hepcidin, Hyperferritinaemia | Deregulated Nutrient Sensing | While hyperferritinaemia is associated with markers of liver injury and insulin resistance, serum hepcidin and hepatic iron are the strongest predictors of ferritin levels. | 28679028 |
| Carcinoma of lung | Deregulated Nutrient Sensing | Immunoblot analysis of the human normal appearing adjacent and lung cancer paired tissue lysates revealed cancer-specific MRS overexpression, which was related to mTORC1 activity. | 28679377 |
| Osteoporosis, Dyslipidemias, Diabetes Mellitus, Hypothyroidism, Malignant Neoplasms, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most frequently associated diseases were: hypertension, 29.8%; dyslipidemia, 27.1%; osteoporosis, 19.1%; diabetes, 12.4%; hypothyroidism, 6.2%; solid malignancies 4.4%. | 28681250 |
| Primary malignant neoplasm, Breast Carcinoma | Deregulated Nutrient Sensing | Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis. | 28682735 |
| Fatty Liver, Inflammation, Obesity | Deregulated Nutrient Sensing | The inflammatory kinases IKKe and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. | 28683283 |
| Obesity | Deregulated Nutrient Sensing | Positive Association of Obesity and Insulin Resistance With Bone Mineral Density in Tunisian Postmenopausal Women. | 28687244 |
| Obesity | Deregulated Nutrient Sensing | The association of bone mineral density (BMD) with obesity and insulin resistance remains unclear. | 28687244 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin's microvascular action is impaired with insulin resistance and type 2 diabetes. | 28687542 |
| Obesity, Bipolar Disorder | Deregulated Nutrient Sensing | The Relation of Light-to-Moderate Alcohol Consumption to Glucose Metabolism and Insulin Resistance in Nondiabetic Adults: the Moderating Effects of Depressive Symptom Severity, Adiposity, and Sex. | 28688095 |
| Bipolar Disorder | Deregulated Nutrient Sensing | We examined the relation of alcohol consumption to glucose metabolism and insulin resistance (IR) as a function of depressive symptoms, adiposity, and sex. | 28688095 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | HCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes. | 28688190 |
| Dyslipidemias | Deregulated Nutrient Sensing | Risk factors associated with atherogenic dyslipidemia in the presence of optimal statin therapy. | 28689987 |
| Dyslipidemias, Data types - Address | Deregulated Nutrient Sensing | Based on the Chinese guideline for the management of dyslipidemia, 13,551 patients reached LDL-C goals, and 7719 patients of them had AD. | 28689987 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | There was no difference in age at onset, sex, BMI and incidence of diabetes mellitus, hypertension or dyslipidemia. | 28691207 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Patients with MetS were older and 49% had insulin resistance. | 28692538 |
| Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Adenoma, Hypertension, CTCAE | Deregulated Nutrient Sensing | Advanced adenoma and cancer were significantly more frequent in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus (P = 0.019). | 28694666 |
| Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Adenoma, Hypertension, CTCAE | Deregulated Nutrient Sensing | Advanced adenoma and cancer were more common in patients with at least two of the following conditions: hypertension, dyslipidemia, and diabetes mellitus. | 28694666 |
| Primary malignant neoplasm, Tuberous Sclerosis | Deregulated Nutrient Sensing | Increased mTORC1 signaling from TSC1/TSC2 inactivation is found in cancer and causes tuberous sclerosis complex (TSC). | 28695825 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | A Tsc2/mTORC1 expression signature identified in Tsc2-deficient fibroblasts was also increased in bladder cancers with TSC1/TSC2 mutations in the TCGA database. | 28695825 |
| Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Degenerative polyarthritis, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Obesity has become a major public health concern over the past several decades and has been shown to be associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, osteoarthritis (OA), and certain types of cancer. | 28695973 |
| Periodontitis | Deregulated Nutrient Sensing | Involvement of insulin resistance in normoglycaemic obese patients with periodontitis: A cross-sectional study. | 28696512 |
| Periodontitis, Obesity | Deregulated Nutrient Sensing | We explored the association between obesity and periodontitis with the aim of determining the possible role of insulin resistance (IR) in this relationship. | 28696512 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The impact of parental history of type 2 diabetes on hyperinsulinemia and insulin resistance in subjects from central Mexico. | 28697997 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent, Pathology | Deregulated Nutrient Sensing | Hyperinsulinemia and insulin resistance are both associated with the development of Type 2 Diabetes and other pathologies; however, the influence of parental history of Type 2 diabetes (PH-T2D) has yet to be investigated. | 28697997 |
| Increased insulin level | Deregulated Nutrient Sensing | Logistic regression was used to determine the association (odds ratio) between PH-T2D and hyperinsulinemia or insulin resistance. | 28697997 |
| Increased insulin level | Deregulated Nutrient Sensing | Subjects having one or both parents were associated with an increase risk of developing hyperinsulinemia (odds ratio=1.53, 95%CI: 1.12-2.09, and odds ratio=1.92, 95%CI: 1.21-3.06, respectively) and insulin resistance (odds ratio=1.47, 95%CI: 1.08-2.00 and odds ratio=1.77, 95%CI: 1.09-2.87, respectively), when adjusting for age, sex, BMI, fasting plasma glucose, and triglycerides. | 28697997 |
| Increased insulin level | Deregulated Nutrient Sensing | The presences of PH-T2D significantly increased the risk of developing hyperinsulinemia and insulin resistance. | 28697997 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Association of divalent cations and insulin resistance with thyroid hormones in patients with type 2 diabetes mellitus. | 28701285 |
| Dyslipidemias, Comorbidity, Diabetes Mellitus | Deregulated Nutrient Sensing | Correlation among Glycemic control, Insulin resistance, Thyroid hormones, divalent cations and dyslipidemia depict differential characteristics in obese and non-obese type2 diabetes with Thyroid comorbidity. | 28701285 |
| Obesity, Hostility | Deregulated Nutrient Sensing | Because obesity promotes insulin resistance and obese individuals tend to report higher levels of pessimism and cynical hostility, an interaction with body mass index (BMI) was explored. | 28703425 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | ETV-treated patients were older (median age: 60 vs 55, P<.01), had similar smoking and hypertension rates, but diabetes and dyslipidemia were more prevalent (19% vs 9%, P=.01; 14% vs 6%, P=.05, respectively). | 28707319 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Coronary Arteriosclerosis, Angina Pectoris | Deregulated Nutrient Sensing | Oxidative stresses and dyslipidemia are an important risk factor in the development of coronary atherosclerotic complications like angina pectoris and myocardial infarction. | 28707864 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | The hypermethylated in cancer 1/sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin-induced damage-repair system. | 28708932 |
| Acoma race, Aneurysm, Dyslipidemias | Deregulated Nutrient Sensing | Univariate analyses showed that the rate of IPR was significantly higher in the treatment of aneurysms with a small dome size, aneurysms in the anterior communicating artery (AcomA) (6.6%), and patients with a medical history of dyslipidemia. | 28710085 |
| TG gene, Obesity, CD55 gene, Hypertension, CTCAE, Overweight | Deregulated Nutrient Sensing | These findings suggest that the mediators, insulin/insulin resistance, TG, TC, and FG, could be targeted for preventing hypertension among populations who were overweight or obesity. | 28710353 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. | 28714974 |
| Coronary Artery Disease | Deregulated Nutrient Sensing | Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes. | 28714974 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, dyslipidaemia, and cardiovascular risk in HIV-infected adults in Poland. | 28715065 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Increasing plasma glucose levels and insulin resistance can alter the distribution pattern of fluorine-18-labeled fluorodeoxyglucose (18F-FDG) in the brain and relatively reduce 18F-FDG uptake in Alzheimer's disease (AD)-related hypometabolic regions, leading to the appearance of an AD-like pattern. | 28715453 |
| Heart Diseases, Hypertension, CTCAE, Dyslipidemias, Tacca leontopetaloides | Deregulated Nutrient Sensing | There was also a significant increase in prevalence of hypertension (67.4% to 77.3%), structural heart disease (9.8% to 10.5%), and previous TIA (10.9% to 13.7%) and a significant decrease in prevalence of dyslipidemia (71.8% to 49.4%). | 28716216 |
| Arteriosclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Data were collected from the Dyslipidemia Registry of the Spanish Arteriosclerosis Society. | 28717233 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Comorbidities were also identified, such as diabetes, hypertension and dyslipidemia. | 28724036 |
| Noncommunicable Diseases, Prediabetes syndrome | Deregulated Nutrient Sensing | The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials. | 28724644 |
| Noncommunicable Diseases, Prediabetes syndrome | Deregulated Nutrient Sensing | Magnesium supplementation resulted in a mean reduction of 4.18 mm Hg in SBP and 2.27 mm Hg in DBP.Conclusion: The pooled results suggest that magnesium supplementation significantly lowers BP in individuals with insulin resistance, prediabetes, or other noncommunicable chronic diseases. | 28724644 |
| Dyslipidemias, Hypertension, CTCAE, Chronic Kidney Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | There was higher proportion of people with hypertension, diabetes mellitus, dyslipidaemia, and chronic kidney disease among people treated with VKA. | 28725983 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | As the second objective, to clarify the factors leading to this inverse association, the contribution of conventional risk factors, such as age, gender, hypertension, smoking, diabetes, obesity and dyslipidemia, to VHD and CAD were examined by multivariate analysis. | 28727835 |
| Hypertensive disease, Dyslipidemias, Overweight, Diabetes Mellitus | Deregulated Nutrient Sensing | Results Among 200 patients (mean age 61.7 +- 9.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP. | 28728485 |
| Arterial Stiffness, Overweight | Deregulated Nutrient Sensing | Relationship between neck circumference, insulin resistance and arterial stiffness in overweight and obese subjects. | 28728486 |
| Pre-Gestational Diabetes | Deregulated Nutrient Sensing | Fasting plasma glucose (FBG), insulin, insulin resistance, glycated haemoglobin and Human Placenta Lactogen(HPL)were significantly (p<0.0001) increased in the pregestational diabetic women whereas progesterone and estradiol were significantly decreased. | 28732072 |
| Gestational Diabetes | Deregulated Nutrient Sensing | In the second trimester however, there was no significant difference (p>0.05) in estradiol, insulin, insulin resistance and HPL between the pregnant women who developed gestational diabetes and those who did not. | 28732072 |
| deficiency aspects, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type II diabetes (T2D) is preceded by prolonged insulin resistance and relative insulin deficiency incompletely captured by glucose metabolism parameters, high-density lipoprotein (HDL) cholesterol and triglycerides. | 28733174 |
| Fatty degeneration, Obesity | Deregulated Nutrient Sensing | BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. | 28733781 |
| Weight Gain | Deregulated Nutrient Sensing | Benzyl isothiocyante and S-carvone blocked high-fat diet-induced weight gain, fat accumulation in the liver, and insulin resistance. | 28733781 |
| Polycystic Ovary Syndrome, Obesity | Deregulated Nutrient Sensing | Bioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: Relationships with obesity and insulin resistance. | 28734987 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | In PCOS, total and free 25(OH)D were related to markers of insulin resistance and lipids. | 28734987 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | DBP was not associated with insulin resistance or BMI in PCOS. | 28734987 |
| Increased insulin level, Infertility, Prostate Cancer Outcomes Study, Dyslipidemias, Subfertility, Obesity | Deregulated Nutrient Sensing | In several cases, PCOS women show infertility or subfertility and other metabolic alteration, such as insulin resistance (InsR), dyslipidaemia, hyperinsulinemia and obesity. | 28735644 |
| Obesity, Dysbiosis | Deregulated Nutrient Sensing | DBZ is a putative PPARg agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis. | 28736228 |
| Weight Gain, Steatohepatitis, Inflammation | Deregulated Nutrient Sensing | DBZ protects against HFD-induced body weight gain, insulin resistance, hepatic steatosis and inflammation in mice. | 28736228 |
| Pain Distress Question, Inflammation, Diabetic Ketoacidosis, Nephrolithiasis | Deregulated Nutrient Sensing | Nephrolithiasis can increase insulin resistance due to increased pain and inflammation, so these patients should be monitored closely for recurrence of DKA. | 28737266 |
| Migraine Disorders, Prediabetes syndrome, Demographics Domain | Deregulated Nutrient Sensing | Insulin resistance seems to exist in individuals with both migraine and prediabetes, and there is a possible negative association between DM and migraine. | 28738109 |
| melanoma | Deregulated Nutrient Sensing | Specially, miR-23a-ATG12 axis attenuated melanoma invasion and migration through autophagy-mediated AMPK-RhoA pathway. | 28740547 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Insulin resistance is associated with higher breast cancer (BC) penetrance in BRCA mutation carriers. | 28741383 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Circulating CTRP9 levels are increased in patients with newly diagnosed type 2 diabetes and correlated with insulin resistance. | 28743061 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We conclude that CTRP9 was strongly associated with insulin resistance, suggesting that CTRP9 might be important in the development of type 2 diabetes. | 28743061 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis. | 28743062 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | GZB and PI-9 could be effective modulators for inflammation and insulin resistance in atherosclerosis. | 28743062 |
| Dyslipidemias, Myocardial Ischemia | Deregulated Nutrient Sensing | Dyslipidemia and the use of statins was associated with culture establishment for IHD patients (p = 0.049 and p = 0.006, respectively). | 28743269 |
| Perimenopausal state, Cardiovascular Diseases, Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE | Deregulated Nutrient Sensing | An educational intervention can be an effective method of reducing the parameters associated with an increased likelihood of cardiovascular disease in women at perimenopausal age with hypertension, diabetes mellitus and/or dyslipidaemia. | 28743399 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Patients (n = 792) with NCCDs (obesity, systemic arterial hypertension, type 2 diabetes mellitus or dyslipidaemia) attended clinics of the public health service of the city of Uberlandia, Minas Gerais State, Brazil. | 28743872 |
| Weight Gain, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Factors associated with weight gain, hypertension and dyslipidaemias were analyzed. | 28750616 |
| Weight Gain, Dyslipidemias | Deregulated Nutrient Sensing | Weight gain, overweight/obese, older age, progression to post/peri-menopausal status at study entry, having received corticosteroid premedication before adjuvant chemotherapy and having received taxane-containing adjuvant chemotherapy were associated with increased risk of dyslipidaemias. | 28750616 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Further, a significant proportion of patients were detected to have hypertension and dyslipidaemias. | 28750616 |
| Hepatitis C | Deregulated Nutrient Sensing | Lack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance. | 28753979 |
| Hepatitis C | Deregulated Nutrient Sensing | The role of hepatitis C virus (HCV) in insulin resistance (IR) is not fully understood. | 28753979 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Dyslipidemia was significantly higher in ischemic stroke (OR = 2.65, 95% CI: 1.21-5.8). | 28756758 |
| Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | The conducted examinations indicated the contribution of adipocytokines-the biologically-active mediators of systemic metabolism, such as leptin and adiponectin in the pathomechanism of disorders being the basis for obesity which leads to development of insulin resistance, which, in turn, results in the occurrence of type 2 diabetes. | 28758947 |
| Steatohepatitis, Obesity | Deregulated Nutrient Sensing | Our current data suggested that children with liver steatosis was highly associated with obesity, and insulin resistance. | 28759573 |
| Sarcopenia, Cardiovascular Diseases | Deregulated Nutrient Sensing | Sarcopenia, or loss of muscle mass, occurs with aging and results in frailty, disability, cardiovascular disease, and insulin resistance. | 28760192 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia tends to contribute to increased serum fructosamine concentrations in study population, suggesting that elevated serum fructosamine may herald an increased risk of cardiovascular disease among community-dwelling adults, especially in males. | 28761149 |
| Inflammation, Dyslipidemias | Deregulated Nutrient Sensing | The LOX index is closely associated with smoking heaviness as well as dyslipidemia and an inflammation marker. | 28761986 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension (71%) and dyslipidaemia (62%) were common comorbidities. | 28764700 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | Visceral adipose tissue is more strongly associated with insulin resistance than subcutaneous adipose tissue in Chinese subjects with pre-diabetes. | 28776439 |
| Prediabetes syndrome | Deregulated Nutrient Sensing | VAT was more strongly associated with insulin resistance than SAT in Chinese subjects with pre-diabetes. | 28776439 |
| Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | Insulin resistance (IR), type 2 diabetes and the risk for development of cardiovascular disease was recently associated as an extended phenotype of the disease. | 28778179 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia was observed in 55.5% of the patients. | 28778179 |
| Rheumatoid Arthritis, Cholelithiasis, Dyslipidemias, Comorbidity | Deregulated Nutrient Sensing | High Prevalence of Gallstone Disease in Rheumatoid Arthritis: A New Comorbidity Related to Dyslipidemia? | 28778575 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | However, the effect of mTORC1 activation in epithelial cells on pterygium development has not yet been reported. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | Additionally, the roles of mTORC1 in aberrant apoptosis and cell proliferation during the initiation of pterygium, and the underlying mechanisms, are not known. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | The results revealed that mTOR signalling, especially mTORC1 signaling, is highly activated, and aberrant apoptosis and cell proliferation were observed in pterygium. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | mTORC1 activation inhibits apoptosis in pterygium by regulating Beclin 1-dependent autophagy via targeting Bcl-2. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | mTORC1 also negatively regulates fibroblast growth factor receptor 3 (FGFR3) through inhibition of p73, thereby stimulating cell proliferation in pterygium. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | These data demonstrate that mTORC1 signalling is highly activated in pterygium and provide new insights into the pathogenesis and progression of pterygium. | 28779179 |
| Pterygium Of Conjunctiva And Cornea | Deregulated Nutrient Sensing | Hence, mTORC1 may be a novel therapeutic target for the treatment of pterygium. | 28779179 |
| ARCN1 gene, Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | At multiple regression analysis the presence of dyslipidemia, COPD and AH were associated with the presence of endothelial dysfunction. | 28779547 |
| Dyslipidemias | Deregulated Nutrient Sensing | Urbanization, mainly rurality, but not altitude is associated with dyslipidemia profiles. | 28780399 |
| Low-Density Lipoproteins, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The outcomes of interest were 6 dyslipidemia traits: hypertriglyceridemia, high low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol (HDL-c), nonisolated low HDL-c, isolated low HDL-c, and high non-HDL-c. | 28780399 |
| Dyslipidemias | Deregulated Nutrient Sensing | The most common dyslipidemia pattern was high non-HDL-c with a prevalence of 88.0% (95% CI: 84.9%-90.7%) in the rural area and 96.0% (95% CI: 94.5%-97.1%) in the semi-urban area. | 28780399 |
| Dyslipidemias | Deregulated Nutrient Sensing | Urbanization but not altitude was associated to several dyslipidemia traits, with the exception of high non-HDL-c in high altitude settings. | 28780399 |
| Infarction, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The PSR group also had more diabetes, dyslipidemia, smoking, infarcts from small-vessel disease, and "other definite" causes and worse onset NIHSS scores. | 28783808 |
| Cataract, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Considering his glucose intolerance and cataracts as complications of corticosteroid treatment, administration of pirfenidone was initiated with the patient's consent. | 28784103 |
| RETINOSCHISIS 1, X-LINKED, JUVENILE, Reed-Sternberg Cells | Deregulated Nutrient Sensing | Aberrant distributions of SIRT1, SIRT4, and SIRT6 were detected in Hodgkin neoplastic Reed-Sternberg (RS) cells compared with reactive elements. | 28786706 |
| RETINOSCHISIS 1, X-LINKED, JUVENILE, Carcinogenesis | Deregulated Nutrient Sensing | Expression levels of SIRT1, 4, and 6 were abnormally distributed in RS cells, suggesting a putative role of aberrant acetylation in classical HL carcinogenesis. | 28786706 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The association of anthropometric indicators with hypertension and dyslipidemia showed heterogeneous results. | 28789915 |
| Squamous cell carcinoma of esophagus | Deregulated Nutrient Sensing | Furthermore, MACC1 knockdown inactivated AMPK-ULK1 signaling pathway, and metformin could rescue MACC1-induced autophagy in ESCC cells. | 28791376 |
| Squamous cell carcinoma of esophagus, Neoplasm Metastasis | Deregulated Nutrient Sensing | Collectively, this study found that upregulation of MACC1 in ESCC was associated with lymph node metastasis of patients, and MACC1 regulated ESCC cell proliferation, apoptosis, migration and invasion mainly through AMPK-ULK1 induced autophagy. | 28791376 |
| Peripheral Vascular Diseases, Blood coagulation, Dyslipidemias | Deregulated Nutrient Sensing | Endovascular treatment with stenting in patients with atherosclerotic peripheral arterial disease is effective, but the risk of primary patency loss was affected by the presence of dyslipidemia, age, and blood coagulation parameters. | 28791851 |
| Chronic cholecystitis, Cerebral Infarction, Presenile dementia, Dyslipidemias, Epilepsy | Deregulated Nutrient Sensing | She was hospitalized with an old cerebral infarction complicated with symptomatic epilepsy, dementia, dyslipidemia, and chronic cholecystitis. | 28794360 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Dyslipidemia and hypertension were the most prevalent dyad among both men and women. | 28796598 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Dyslipidemia, hypertension, and diabetes were the most prevalent triad among both men and women. | 28796598 |
| Obesity | Deregulated Nutrient Sensing | Obesity was the only factor independently associated with insulin resistance (adjusted odds ratio: 2.28; 95% confidence interval: 1.10-4.72). | 28797289 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance is present in nearly half of HIV-infected patients in Cameroon despite a low prevalence rate of diabetes, and is associated with obesity. | 28797289 |
| Cholelithiasis | Deregulated Nutrient Sensing | The association between BMI and gallstone disease was explained by insulin resistance. | 28799434 |
| Inflammation, Cholelithiasis, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Biomarkers of insulin resistance, systemic inflammation and genetic obesity or type 2 diabetes risk alleles seem to be associated with gallstone disease. | 28799434 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon. | 28801428 |
| HIV Infections | Deregulated Nutrient Sensing | The relationship between cardiovascular risk and insulin resistance in black African patients with HIV infection seems to depend on the cardiovascular risk equation used. | 28801428 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The rates of obesity, dyslipidemia, and diabetes showed partial statistical difference between the two groups. | 28803419 |
| Inflammation, Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD) affects 20%-30% of adults with risk factors like obesity and insulin resistance putatively acting through chronic low-grade inflammation. | 28804947 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | When ATM gene is mutated, this event appears to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). | 28806901 |
| Chronic Kidney Insufficiency, Dyslipidemias | Deregulated Nutrient Sensing | Compared with nonoctogenarians, we observed higher prevalence of dyslipidemia (P = 0.02), and chronic renal insufficiency (P = 0.02) during follow-up. | 28807220 |
| Malignant neoplasm of skin, Dyslipidemias, Kidney Failure | Deregulated Nutrient Sensing | For those surviving into their 80s, cardiac function is preserved but dyslipidemia, renal insufficiency, and skin cancers are common. | 28807220 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Many investigators have examined the functions of AMP-activated protein kinase (AMPK) in cancer biology and its anti-neoplastic features in cancer models. | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | AMPK expression patterns are significantly associated with poor prognosis in breast cancer patients. | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | The goal of this research is to assess the association of the immunohistochemical expression of AMPK in human mammary tumours with the clinical data of breast cancer patients. | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | 449 cases of previously diagnosed breast cancer, and 27 tissue samples of fibroadenomas and normal breast were utilized for detection of AMPK expression using tissue microarrays and immunohistochemistry. | 28807345 |
| Primary malignant neoplasm | Deregulated Nutrient Sensing | Brownish nuclear and cytoplasmic staining were present in epithelial cells and stromal cells in 333 (74.16%) and 348 (77.5%) cancer cases respectively indicating AMPK expression. | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Significant statistical association has been found between advanced stages of breast cancer and increased intensity of AMPK immunostaining only in epithelial cells (p-value=0.0001). | 28807345 |
| Noninfiltrating Intraductal Carcinoma | Deregulated Nutrient Sensing | Low AMPK immunostaining scores were more dominant in DCIS, ductal and mixed type's ductal and mucinous histotypes, while high intense staining was more common in the lobular type. | 28807345 |
| Mammary Neoplasms, P-Value | Deregulated Nutrient Sensing | Furthermore, breast tumour cases with lymph node metastases showed significant AMPK expression in both epithelial and stromal cells (p-value=0.0001 and p-value=0.026). | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Low scores of AMPK immunostaining were common in breast cancer cases with positive vascular invasion (p-value=0.007) and disease recurrence (p-value=0.008). | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | In conclusion, our results showed decreased AMPK expression in breast cancer in comparison with the control group. | 28807345 |
| Vascular Invasion Assessment | Deregulated Nutrient Sensing | AMPK expression was significantly correlated with some clinicopathological factors like advanced stage, lymph node involvement, vascular invasion and disease recurrence which give indications for poor clinical outcomes. | 28807345 |
| Breast Carcinoma | Deregulated Nutrient Sensing | Immunohistochemical staining of AMPK protein is a valuable method which could predict cases of breast cancer with poor prognosis. | 28807345 |
| Hypertension, CTCAE, Hyperuricemia | Deregulated Nutrient Sensing | Temporal Relationship Between Hyperuricemia and Insulin Resistance and Its Impact on Future Risk of Hypertension. | 28808071 |
| Hypertension, CTCAE, Hyperuricemia | Deregulated Nutrient Sensing | Although hyperuricemia and insulin resistance significantly correlated, their temporal sequence and how the sequence influence on future risk of hypertension are largely unknown. | 28808071 |
| Hypertensive (finding) | Deregulated Nutrient Sensing | The path coefficients from baseline uric acid to follow-up insulin resistance indices in the hypertensive group were significantly greater than that in the normotensive group (P<0.001 for the difference of b1 values in the 2 groups). | 28808071 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | These findings provide evidence that higher uric acid levels probably precede insulin resistance, and peripheral insulin resistance likely plays a more important role in the development of hypertension than hepatic insulin resistance does. | 28808071 |
| Tuberculosis, Pulmonary, Tuberculosis | Deregulated Nutrient Sensing | The association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study. | 28810840 |
| Tuberculosis | Deregulated Nutrient Sensing | The existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. | 28810840 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | The mechanisms by which each respective isoform contributes to obesity and insulin resistance may reveal novel treatment strategies for diabetes. | 28811295 |
| Cardiovascular Diseases | Deregulated Nutrient Sensing | Because preterm birth (PT) increases the risk for cardiovascular diseases during neonatal period as well as at adulthood, we hypothesized that SIRT1 deficiency could control the biogenesis of microparticles as part of a senescence-associated secretory phenotype (SASP) of PT-ECFC and investigated the related molecular mechanisms. | 28811647 |
| Obesity | Deregulated Nutrient Sensing | Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey. | 28812029 |
| Obesity | Deregulated Nutrient Sensing | This study aims to expand the evaluation of normal weight obesity (NWO) and its association with insulin resistance using an NHANES (1999-2006) sample of US adults. | 28812029 |
| Dyslipidemias, Coronary Artery Disease, Electrocardiogram: left ventricle hypertrophy (finding), Hypertension, CTCAE, Overweight, Cardiac Arrhythmia | Deregulated Nutrient Sensing | Of the 137 elderly, the study found the following: women (75.9%); overweight (48.2%); obese (30.6%); increase in the index waist/hip (88.3%); dyslipidaemia (94.2%) and hypertension (91.2%); coronary artery disease (35.0%); and 27.7% with cardiac arrhythmia or left ventricular hypertrophy. | 28817241 |
| Hyperglycemia | Deregulated Nutrient Sensing | Hyperglycemia and elevated insulin-resistance were associated with low TBS independently of bone turnover and pentosidine levels. | 28821456 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | In addition, the risks for insulin resistance increased with OSAS severity without fully adjustment. | 28821856 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | An OSAS x smoking interaction was found in insulin resistance after adjusting for potential confounding factors (p = 0.025). | 28821856 |
| Sleep Apnea, Obstructive | Deregulated Nutrient Sensing | Cessation of cigarette smoking may experience minor benefit for insulin resistance and lipid metabolism in patients with OSAS. | 28821856 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Arterial hypertension is a disease that often coexists with dyslipidemia. | 28822022 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Higher levels of eryptosis have not been described in patients with hypertension, dyslipidemia, or both combined. | 28822022 |
| Hypertensive (finding), Dyslipidemias | Deregulated Nutrient Sensing | Mean [Ca2+]i in hypertensive patients was 100 and 200% higher, in patients without and with dyslipidemia, respectively, compared to normotensive patients. | 28822022 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We identified 168 women (20%) with hypertension, 64 (7.6%) with diabetes mellitus, and 98 (11.7%) with dyslipidaemia. | 28826038 |
| Triglycerides | Deregulated Nutrient Sensing | However, after adjusting for different indicators of adiposity, insulin resistance remained independently associated and the association with hypertriacylglycerolaemia was lost after adjusting for central adiposity. | 28829285 |
| Damage | Deregulated Nutrient Sensing | Good results will be achieved by applying liraglutide in intervention with different phases of DN and DM patients, which cannot only regulate the gastrointestinal hormone levels and lower the blood sugar levels of patients, but can also reduce the insulin resistance and delay the process of renal damage. | 28829486 |
| Dyslipidemias | Deregulated Nutrient Sensing | Lpa, dyslipidaemia and smoking were significantly higher (p=0.006, p<=0.0001 and p=0.001, respectively) in CAC+ patients. | 28830786 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In individuals with type 2 diabetes, Bmal1, Per1, Per2, Rev-erba, and Ampk increased (P < 0.05) after lunch on the YesB day. | 28830875 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | In contrast, in individuals with type 2 diabetes, Per1, Per2, and Sirt1 only slightly, but significantly, decreased and Rora increased (P < 0.05) after breakfast. | 28830875 |
| Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Adiposity seems to be primarily responsible for an increase in inflammatory markers, leading through this mechanism to insulin resistance and increasing diabetes risk. | 28834086 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia ( P < .001), chronic kidney disease ( P = .004), and transient transfection, nuclear factor k-Light-Chain-Enhancer of activated B (NF-kB) cultured endothelial cells ( P = .007) and was positively associated with height ( P = .008). | 28835113 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | Increasing evidence suggested that VLDL-C was known as a significant risk factor for atherosclerosis and had been recommended as a treatment target by current dyslipidemia guidelines. | 28836572 |
| Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Fractional esterification rate of cholesterol in high-density lipoprotein (FERHDL) has been found to be closely correlated with atherosclerotic dyslipidemia, especially lipoprotein distributions, and is a potentially useful predictor for coronary heart disease (CHD). | 28836980 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | It can lead to dyslipidemia and be the risk factor of cardiovascular disease due to low estrogen level. | 28838227 |
| hepcidin | Deregulated Nutrient Sensing | It has been shown that hepcidin and YKL-40 levels change in persons with insulin resistance in different circumstances. | 28841871 |
| Hyperglycemia | Deregulated Nutrient Sensing | The Role of Hyperglycemia, Insulin Resistance, and Blood Pressure in Diabetes-Associated Differences in Cognitive Performance-The Maastricht Study. | 28842522 |
| Dyslipidemias, Breast Carcinoma, Diabetes Mellitus | Deregulated Nutrient Sensing | Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. | 28842914 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | By receiver operating characteristic analysis, EAT-AIG thickness had a high C statistic (area under the curve = 0.81, P < .001) after adjustment for conventional risk factors (smoking, diabetes mellitus, and dyslipidemia). | 28843368 |
| Proximal tubulopathy, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Increased uNGAL and uNCR may indicate early tubular damage, associated with dyslipidemia and worse diabetes control, especially in females with T2DM. | 28845433 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The risk of type 2 diabetes is increasing in teenage girls, and is associated with their greater insulin resistance (IR). | 28851041 |
| Dyslipidemias, Hypertension, CTCAE, Sarcopenia, Diabetes Mellitus | Deregulated Nutrient Sensing | Furthermore, diabetes and hypertension, but not dyslipidemia, were found to be significantly associated with sarcopenia. | 28851881 |
| Alzheimers Disease", Data types - Address | Deregulated Nutrient Sensing | Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer's disease (AD) pathological features. | 28852028 |
| Hyperglycemia, ETV3 wt Allele, Obesity | Deregulated Nutrient Sensing | Those who were uaHB had a higher risk of central obesity, hyperglycemia, insulin resistance, and MetS than those who were aHB (odds ratio = 2.33, 1.64, 2.15, 1.85, respectively, all p < 0.05). | 28852048 |
| Bone necrosis | Deregulated Nutrient Sensing | SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis. | 28856724 |
| Osteonecrosis of Jaw | Deregulated Nutrient Sensing | In summary, we identified the SIRT1/HERC4 locus on chromosome 10 to be associated with iv BP-induced ONJ and two promoter SNPs that might be the potential genetic markers for this association. | 28856724 |
| Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS. | 28860506 |
| Chronic liver disease, Glucose Intolerance (disease) | Deregulated Nutrient Sensing | Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. | 28860506 |
| Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease, Hepatitis C, Chronic | Deregulated Nutrient Sensing | However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. | 28860506 |
| Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In conclusion, obvious differences in the characteristics of glucose intolerance between patients with NAFLD and those with C-CH were clarified. | 28860506 |
| Fibrosis, Liver, Glucose Intolerance (disease), Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | In patients with NAFLD, glucose intolerance gradually progressed in accordance with the progression of hepatic fibrosis. | 28860506 |
| Glucose Intolerance (disease), Hypoalbuminemia | Deregulated Nutrient Sensing | In those with C-CH, glucose intolerance suddenly developed upon the appearance of hypoalbuminaemia. | 28860506 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | SIRT1 rs10823108 and FOXO1 rs17446614 responsible for genetic susceptibility to diabetic nephropathy. | 28860538 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | SIRT1 and FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN). | 28860538 |
| Hepatitis C | Deregulated Nutrient Sensing | Interferon-g-inducible protein-10 in chronic hepatitis C: Correlations with insulin resistance, histological features & sustained virological response. | 28862188 |
| Dyslipidemias, Cardiovascular system | Deregulated Nutrient Sensing | The effectiveness of statins in the treatment of dyslipidaemia and reduction of cardiovascular risk is well established. | 28863328 |
| Anxiety, CTCAE 3.0, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension (p < 0.001), diabetes (p < 0.05), dyslipidemia (p < 0.05), type-D personality (p = 0.001) and anxiety (p < 0.001) were more prevalent among patients. | 28865501 |
| Anxiety, CTCAE 3.0, Acute Coronary Syndrome, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Type-D personality, high anxiety, hypertension and dyslipidemia seem to cluster among female acute coronary syndrome patients. | 28865501 |
| Atrial Fibrillation by ECG Finding | Deregulated Nutrient Sensing | The association between insulin resistance and atrial fibrillation: A cross-sectional analysis from SPRINT (Systolic Blood Pressure Intervention Trial). | 28866864 |
| Amyotrophic Lateral Sclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia has been described in ALS patients and may be protective but peripheral lipoprotein subclasses have never been studied. | 28870551 |
| Amyotrophic Lateral Sclerosis, Dyslipidemias | Deregulated Nutrient Sensing | Our preliminary work confirmed the association between ALS and dyslipidemia. | 28870551 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | A higher regional prevalence of hypertension, dyslipidaemia and lack of exercise may be responsible. | 28871014 |
| Dyslipidemias, Hypertension, CTCAE, Benign Paroxysmal Positional Vertigo, Cardiovascular system | Deregulated Nutrient Sensing | The presence of hypertension, dyslipidaemia and pre-existing cardiovascular comorbidities were significantly related to recurrent BPPV episodes (OR range between 1.84 and 2.31). | 28872163 |
| Atrioventricular Block, Hypertrophic Cardiomyopathy, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Complex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes. | 28874324 |
| Cardiomyopathies, Dyslipidemias, Diabetes Mellitus, Lipodystrophy, No metabolic abnormalities | Deregulated Nutrient Sensing | Some mutations, associated with lipodystrophy but not cardiomyopathy, have been linked to metabolic abnormalities such as diabetes and severe dyslipidemia. | 28874324 |
| Atrioventricular Block, Hypertrophic Cardiomyopathy, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Herein we describe a new phenotype associated with a mutation in exon 11 of the LMNA gene: hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes. | 28874324 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We thus investigated whether afamin concentrations are associated with prediabetes, type 2 diabetes, and insulin resistance (IR). | 28877915 |
| Dyslipidemias, Chronic disease, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Younger age, African American race, and chronic disease such as hypertension and dyslipidemia correlated with obesity. | 28880738 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | The prevalence of dyslipidemias, hyperglycemia, and insulin resistance were evaluated, together with the correlations of these variables with the increase of Z-BMI. | 28881179 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | Overweight and obesity give origin to a high prevalence of dyslipidemia and insulin resistance. | 28881179 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Metabolically healthy subjects were defined as those without hypertension, dyslipidemia and diabetes. | 28882469 |
| Primary malignant neoplasm, Cardiovascular Diseases, Dyslipidemias, Heart Diseases, Have, Hypertension, CTCAE | Deregulated Nutrient Sensing | HAS patients were found to have many of the risk factors associated with cardiovascular disease (male sex, ageing, antecedent of cardiac disease, arterial hypertension, dyslipidaemia, smoking habit) and cancer. | 28882641 |
| Dyslipidemias, Atherosclerosis | Deregulated Nutrient Sensing | In the subgroup analysis, the reduction in hard ASCVD events for NHCS participants was significantly greater in patients without a previous history of dyslipidemia or who did not have outpatient care. | 28886857 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | In conclusion, insulin resistance was positively associated CKD with in Korean adults with or without T2DM. | 28890482 |
| Obesity | Deregulated Nutrient Sensing | Further adjustment of mediators, such as central obesity or insulin resistance, attenuated the association to 1.91-2.17. | 28892211 |
| Hyperandrogenemia, Inflammation, Hyperlipidemia, Cardiovascular Diseases, Atherosclerosis | Deregulated Nutrient Sensing | Chronic inflammation, insulin resistance, hyperandrogenemia, hyperlipidemia and increased oxidative stress are known to have a role in the formation of atherosclerosis and cardiovascular disease. | 28892255 |
| Dyslipidemias | Deregulated Nutrient Sensing | Previous national survey suggested that dyslipidemia is an increasing burden in China and more severe in urban population. | 28895638 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is an increasing epidemic in China, characterized by a rising trend of LDL cholesterol. | 28895638 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | The gender and age differences in serum levels of lipid profile as well as prevalence of dyslipidemia suggested that the middle-age men and postmenopausal women should be the prioritized target for better control of dyslipidemia and early prevention of cardiovascular disease. | 28895638 |
| Inflammation, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. | 28895641 |
| Inflammation, square decimeter, Dyslipidemias, Non-alcoholic Fatty Liver Disease, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Considering the high prevalence of non-alcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. | 28895641 |
| Inflammation, Dyslipidemias, Diabetes Mellitus, Fatty Liver Disease | Deregulated Nutrient Sensing | Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease. | 28895641 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Recent reports indicate that fasting glucose levels in non-diabetic patients correlate appropriately with the development of certain elements in metabolic syndrome, which suggest a cause-effect relationship with insulin resistance. | 28895791 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | We explored whether growth differentiation factor 15 (GDF15) affects the histological severity of non-alcoholic fatty liver disease (NAFLD) independent of insulin resistance. | 28898507 |
| Hyperglycemia, Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | A high prevalence of hypertension (51%), dyslipidemia (52%), elevated liver enzyme levels (51%), and hyperglycemia (24%) was found. | 28898874 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | This association was independent of hyperglycemia and dyslipidemia (p = 0.03). | 28898874 |
| Dyslipidemias | Deregulated Nutrient Sensing | Q1 also had higher frequency (+31%) and severity (+20%) of atherogenic dyslipidemia. | 28899393 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Hypertension and the triglyceride and glucose index both have been associated with insulin resistance; however, the longitudinal association remains unclear. | 28903774 |
| Pain Distress Question, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Nevertheless, as compared to other populations, Mexican centenarians report having good self-perception of health (78.9%), polypharmacy (17.8%), low rate of pain (11.4%), diabetes (4.8%), and dyslipidemia (1.8%). | 28904969 |
| Monogenic diabetes, diabetic | Deregulated Nutrient Sensing | Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. | 28913361 |
| Myotonic Dystrophy | Deregulated Nutrient Sensing | Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle. | 28915272 |
| Demographics Domain | Deregulated Nutrient Sensing | We have analysed the insulin pathway in skeletal muscle biopsies and in myotube cultures from DM patients to assess whether downstream metabolism might be dysregulated and to better characterize the mechanism inducing insulin resistance. | 28915272 |
| Sepsis, vascular inflammations, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Previous work revealed a strong role for miR-181b-5p in vascular inflammation in obesity, insulin resistance, sepsis, and cardiovascular disease. | 28916639 |
| Impaired lung function | Deregulated Nutrient Sensing | Young adults with preclinical insulin resistance have a higher risk of impaired lung function. | 28916790 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | RESULTS The comparison between the potential donors in Group A vs. Group B revealed an increase over time in donor age (54.6+-17.2 vs. 58.8+-16.3, p<0.001), a reduction in the percentage of standard donors (52.3% vs. 39.8%, p<0.001), a broader utilization of organs from expanded criteria donors, and a greater number of comorbidities, particularly cardiovascular disease and dyslipidemia. | 28919594 |
| Hypertension, CTCAE, Diabetes Mellitus, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Among survivors only, preexisting cardiovascular factors (hypertension, dyslipidemia, and diabetes) and preexisting cardiovascular disease were ascertained. | 28922087 |
| Prostate carcinoma | Deregulated Nutrient Sensing | Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK). | 28923415 |
| Prostate carcinoma | Deregulated Nutrient Sensing | As DIM is a mitochondrial ATP-synthase inhibitor, we hypothesized that DIM and ring-DIMs induce autophagy via alteration of intracellular AMP/ATP ratios and activation of AMP-activated protein kinase (AMPK) signaling in prostate cancer cells. | 28923415 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Dietary sugars are linked to the development of non-alcoholic fatty liver disease (NAFLD) and dyslipidaemia, but it is unknown if NAFLD itself influences the effects of sugars on plasma lipoproteins. | 28923880 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients with both hypertension and dyslipidemia have 4x higher annual progression rate compared with subjects without these risk factors (0.398 m/s/y versus 0.102 m/s/y). | 28923899 |
| Obesity, Bipolar Disorder | Deregulated Nutrient Sensing | We estimated the association between obesity, insulin resistance, and depressive symptoms by carrying out univariate and multivariate regression analyses. | 28925048 |
| Bipolar Disorder | Deregulated Nutrient Sensing | Our results suggest that depressive symptoms are associated with insulin resistance in older Mexican-American adults. | 28925048 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Individual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study. | 28928169 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The surgery group had higher remission rates and lower incidence rates of hypertension and dyslipidemia than did nonsurgery group 1 (P<0.05 for all comparisons). | 28930514 |
| Rheumatoid Arthritis | Deregulated Nutrient Sensing | Insulin Resistance in Early Rheumatoid Arthritis Is Associated with Low Appendicular Lean Mass. | 28932748 |
| Refractory anemias, Rheumatoid Arthritis | Deregulated Nutrient Sensing | In established rheumatoid arthritis (RA), the presence of insulin resistance (IR) is well proven but, in the early stage of the disease, data are inconclusive. | 28932748 |
| Refractory Cytopenia of Childhood | Deregulated Nutrient Sensing | SIRT1, SIRT3, and SIRT6 expression was significantly lower in RCC than in normal tissues (P = 0.001, P = 0.006, and P = 0.033, respectively), whereas the expression of other SIRT proteins did not differ significantly between the 2 tissues. | 28935184 |
| Refractory Cytopenia of Childhood, Neoplasms | Deregulated Nutrient Sensing | Our results provide preliminary evidence suggesting that SIRT1, SIRT3, and SIRT6 function as tumor suppressors in RCC. | 28935184 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Gut bacterial translocation to the blood may play an important role in the development of insulin resistance in type 2 diabetes. | 28935921 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Obesity, Cardiovascular Diseases | Deregulated Nutrient Sensing | Obesity is associated with hypoadiponectemia, dyslipidemia, and increased risk of cardiovascular disease (CVD). | 28938424 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Findings were confirmed in Hypertension Insulin-Resistance Study premenopausal women. | 28938457 |
| Obesity | Deregulated Nutrient Sensing | Does Cardiorespiratory Fitness Attenuate the Adverse Effects of Severe/Morbid Obesity on Cardiometabolic Risk and Insulin Resistance in Children? | 28939688 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Prostate, Cessation of life | Deregulated Nutrient Sensing | anti-diabetes, anti-dyslipidaemia, and antihypertension) in relation to all-cause, cardiovascular disease (CVD), and prostate cancer-specific death were studied using multivariate Cox proportional hazard and Fine and Gray competing regression models. | 28940667 |
| Hyperglycemia, Hypertension, CTCAE, Prostate carcinoma, Dyslipidemias | Deregulated Nutrient Sensing | We did not find evidence for a better or worse response to GnRH agonists in men with prostate cancer who were also on drugs for hypertension, dyslipidaemia, or hyperglycaemia. | 28940667 |
| Steatohepatitis | Deregulated Nutrient Sensing | Taken together, these findings suggest that BSE promotes degradation of lipid droplets and subsequent activation of fat oxidation by activating AMPK in the liver, thus protecting against development of hepatic steatosis in alcohol-fed mice. | 28941686 |
| LIPC gene | Deregulated Nutrient Sensing | Saponarin, a major flavonoid in BSE and an activator of AMPK, increased the activity of microsomal triglyceride transfer protein, which suggests that the reduction in hepatic triglyceride levels was mediated by this component of BSE. | 28941686 |
| Malignant tumor of colon | Deregulated Nutrient Sensing | Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA. | 28943452 |
| Malignant tumor of colon, Neoplasm Metastasis | Deregulated Nutrient Sensing | Moreover, HNF1A-AS1 functioned as an oncogene in metastasis of colon cancer in part through serving as a competing endogenous RNA to modulate miRNA-34a expression, subsequently with repression of miR-34a/SIRT1/p53 feedback loop and activation of canonical Wnt signaling pathway. | 28943452 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | The Serum Level of KL-6 Is Associated with the Risk of Insulin Resistance and New-onset Diabetes Mellitus: The Tanno-Sobetsu Study. | 28943558 |
| Chronic Obstructive Airway Disease, Pneumonitis, Diabetes Mellitus | Deregulated Nutrient Sensing | The involvement of pulmonary inflammation in insulin resistance remains unclear, but smoking is known to be a risk factor for diabetes as well as chronic obstructive pulmonary disease. | 28943558 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Conclusion A modest elevation of the serum KL-6 level is therefore considered to be associated with the risk for insulin resistance development and new-onset diabetes mellitus in a general population. | 28943558 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance (IR) is known to be an important factor, which can lead to the onset of type 2 diabetes. | 28944847 |
| Dyslipidemias, Hypocholesterolemia | Deregulated Nutrient Sensing | As genetics improved the predictive power of dyslipidemia development, only 24 patients need to be genotyped to prevent the development of one case of HDL hypocholesterolemia. | 28945215 |
| muscle mass | Deregulated Nutrient Sensing | After therapy, homeostasis model assessment of insulin resistance, fasting insulin level, and insulin AUC decreased despite an increase in IHL and abdominal and thigh adipose tissues and a decrease in muscle mass. | 28945897 |
| Increased insulin level, Acromegaly | Deregulated Nutrient Sensing | Patients with acromegaly were characterized by insulin resistance and hyperinsulinemia but lower IHL compared with age-, BMI-, and sex-matched healthy controls. | 28945897 |
| Acromegaly, muscle mass | Deregulated Nutrient Sensing | Biochemical control of acromegaly improved insulin resistance but led to a less favorable anthropometric phenotype with increased IHL and abdominal adiposity and decreased muscle mass. | 28945897 |
| Inflammation, Insulin Resistance | Deregulated Nutrient Sensing | Both insulin-resistance and chronic low-grade inflammation are involved in this relationship. | 28946871 |
| Dyslipidemias, Congestive heart failure, malignant disease, Chronic Obstructive Airway Disease, Peripheral Vascular Diseases, Asthma, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Other risk factors of 30-day readmission included female gender, emergency and urgent procedures, certain patient comorbidities (dyslipidemia, congestive heart failure, history of transient ischemic attack, previous cardiac surgery, chronic obstructive pulmonary disease, asthma, chronic kidney disease, peripheral vascular disease, and history of malignant disease), and hemorrhage/shock/bleeding occurring during the index admission as well as nonhome discharge. | 28947230 |
| Metabolic Diseases, Noncommunicable Diseases, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of noncommunicable diseases, including those such as type 2 diabetes, obesity, dyslipidemia, and hypertension, so-called cardiometabolic diseases, is high and is increasing worldwide. | 28947415 |
| Metabolic Diseases, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | We conducted qualitative semistructured interviews in March to May 2016 with 11 senior physicians from a public university hospital in France with expertise in management of cardiometabolic diseases (type 1 and type 2 diabetes, obesity, hypertension, and dyslipidemia). | 28947415 |
| Glucose Intolerance (disease), Injury of liver | Deregulated Nutrient Sensing | This study revealed a novel role of the OST48 and AGE axis in hepatic injury through ER stress, changes in fuel utilisation and glucose intolerance. | 28947796 |
| Glucose Intolerance (disease), Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Serum uric acid (SUA) levels are associated with glucose intolerance and type 2 diabetes. | 28948573 |
| Dyslipidemias, Gastroesophageal reflux disease, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Comorbidity | Deregulated Nutrient Sensing | Among patients with obesity (BMI >=30 kg/m2), those coded for obesity were younger, more often female, and had a greater comorbidity burden than those not coded; hypertension, dyslipidemia, type 2 diabetes mellitus, and gastroesophageal reflux disease were the most common comorbidities. | 28949834 |
| Diabetic Retinopathy, Dyslipidemias, GDC Disease Response Terminology | Deregulated Nutrient Sensing | Results from observational studies examining dyslipidemia as a risk factor for diabetic retinopathy (DR) have been inconsistent. | 28951389 |
| Prediabetes syndrome, Diabetes Mellitus | Deregulated Nutrient Sensing | The incidence of diabetes mellitus is rising worldwide, and prediabetic screening for insulin resistance (IR) has become ever more essential. | 28953643 |
| Adenoma, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | F and E levels were similar among patients with unilateral or bilateral adenoma, or considering the presence of hypertension, dyslipidemia, diabetes, or cardiovascular events. | 28956262 |
| Function (attribute) | Deregulated Nutrient Sensing | Fermented Rice Germ Extract Alleviates Morphological and Functional Damage to Murine Gastrocnemius Muscle by Inactivation of AMP-Activated Protein Kinase. | 28956710 |
| Hernia of abdominal cavity, Gout, Dyslipidemias, Substance abuse problem, Diabetes Mellitus, Hepatobiliary Disorder | Deregulated Nutrient Sensing | Diabetes, gout, dyslipidemia, abdominal hernia, liver disease, alcohol and tobacco use, and substance abuse were higher for men (P < 0.0001). | 28958273 |
| Units Of Measure - Siemens, Obesity | Deregulated Nutrient Sensing | Metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) are differentiated by the presence of cardiometabolic risk factors (CMRFs) and insulin resistance (IR). | 28960038 |
| diabetic | Deregulated Nutrient Sensing | Many studies showed insulin resistance amelioration in HCV-patients achieving Sustained Virologic Response (SVR) but results on glycemic control in diabetic patients are unclear. | 28960353 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | Activating events along the PI3K/mTOR pathway are common in head and neck squamous cell carcinomas (HNSCC), and preclinical studies suggest additive or synergistic effects when combining mTORC1 inhibitors with carboplatin and paclitaxel chemotherapy. | 28961834 |
| PARK7 gene | Deregulated Nutrient Sensing | Because aging is associated with deregulated nutrient sensing, these results help explain why DJ-1 is associated with age-dependent disease. | 28962651 |
| Data types - Address | Deregulated Nutrient Sensing | These results will help us to better understand the protective role of SIRT1 in AD, and they support the potential use of SIRT1 as a biomarker and drug target for the prevention, diagnosis, and treatment of AD as well as other relevant age-related diseases. | 28962864 |
| Squamous cell carcinoma of the head and neck | Deregulated Nutrient Sensing | Prognostic relevance of insulin resistance on disease-free survival in head and neck squamous cell carcinomas: Preliminary results. | 28963801 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | This may indicate that abnormalities in postprandial VLDL-TG metabolism are a consequence of obesity/insulin resistance more than a result of type 2 diabetes per se. | 28964326 |
| Liver carcinoma | Deregulated Nutrient Sensing | Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts. | 28964787 |
| Liver carcinoma, FAM126A gene | Deregulated Nutrient Sensing | We showed here that persistent exposure to a low concentration of metformin led to AMPK activation in a mouse xenograft model of human hepatocellular carcinoma (HCC), resulting in senescence. | 28964787 |
| FAM126A gene | Deregulated Nutrient Sensing | Taken together, these findings suggest that a low dose of metformin could potentially be used as a TIS-inducing therapeutic drug for HCC, and that this occurs by inducing senescence of HCC cells via the AMPK-SIRT1 pathway. | 28964787 |
| Hypertension, CTCAE, ras GTPase-Activating Proteins, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Preventive treatment gaps affected 14% of patients with hypertension, 36% of patients with dyslipidaemia and 32% of patients with diabetes. | 28965093 |
| Dyslipidemias | Deregulated Nutrient Sensing | For patients with dyslipidaemia, the presence of a treatment gap was associated with a higher risk of an adverse event. | 28965093 |
| SLC25A20 gene, Dyslipidemias | Deregulated Nutrient Sensing | Previous studies reporting that statin increases coronary artery calcium (CAC) were conducted exclusively on patients with statin as a prevention, regardless of the presence or absence of dyslipidemia. | 28966320 |
| Inflammation | Deregulated Nutrient Sensing | About 900 DMRs were found and their associated genes were significantly enriched in 32 pathways, the top ones of which were associated with insulin resistance and inflammation. | 28967791 |
| Primary malignant neoplasm, Neoplasms | Deregulated Nutrient Sensing | Taken together, our data demonstrate that deregulation of the PI3K-AKT/ mTORC1/ p70S6K pathways, an event frequently observed in cancer, exert profound effects on genome stability via MRE11 with potential implications for tumour initiation and therapy. | 28967905 |
| Dyslipidemias, Gastroesophageal reflux disease, Acid reflux, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Remission rates of co-morbidities were 83.5% for dyslipidemia (P < 0.001), 65.8% for hypertension (P < 0.001), 62.1% for type 2 diabetes mellitus (T2DM) (P < 0.001), and 60.7% for gastroesophageal reflux (GERD) (P < 0.001). | 28971291 |
| Cardiac complication, Dyslipidemias, Endothelial dysfunction | Deregulated Nutrient Sensing | Research of early predictors of cardiovascular complications: dyslipidemia, insulin resistance, inflammatory marker- C-reactive protein, marker of vascular aging-telomerase activity and marker of endothelial dysfunction (ED) - CDECs and VEGF-A that have been analyzed are on the front burner. | 28972487 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Insulin resistance is a major predictor of the development of metabolic disorders. | 28973648 |
| Obesity | Deregulated Nutrient Sensing | Importantly, we found that SIRT2 expression in PBMCs of human subjects was negatively correlated with obesity and insulin resistance. | 28973648 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | These results suggest a novel function for hepatic SIRT2 in the regulation of insulin sensitivity and raise the possibility that SIRT2 activators may offer novel opportunities for preventing or treating insulin resistance and type 2 diabetes. | 28973648 |
| Electrocardiogram: myocardial infarction (finding), Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | To determine whether, among patients with an ischemic stroke or transient ischemic attack and insulin resistance, those at higher risk for future stroke or myocardial infarction (MI) derive more benefit from the insulin-sensitizing drug pioglitazone hydrochloride compared with patients at lower risk. | 28975241 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | A secondary analysis was conducted of the Insulin Resistance Intervention After Stroke trial, a double-blind, placebo-controlled trial of pioglitazone for secondary prevention. | 28975241 |
| Ischemic stroke | Deregulated Nutrient Sensing | Eligible participants had a qualifying ischemic stroke or transient ischemic attack within 180 days of entry and insulin resistance without type 1 or type 2 diabetes. | 28975241 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Only 23.6% of patients reported to do regular exercise,73.4% had history of hypertension, 47.4% had dyslipidemia and 33.9% had diabetes mellitus. | 28980279 |
| Hypertension, CTCAE, Ischemic stroke, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The risk of AF-associated MI was higher in patients free of hypertension, diabetes, ischemic stroke, and dyslipidemia at baseline. | 28983076 |
| Inflammation, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | This propensity to inflammation may be a driver of the higher risk of cardiovascular disease, insulin resistance and diabetes observed in this population. | 28987777 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The presence of diabetes mellitus, hypertension, and dyslipidemia was defined using the criteria of previous studies. | 28991084 |
| Obesity, Atherosclerosis | Deregulated Nutrient Sensing | Recent studies have shown that A-FABP is secreted by adipocytes and that the A-FABP concentration is associated with obesity, insulin resistance, and atherosclerosis. | 29017449 |
| Malignant tumor of colon | Deregulated Nutrient Sensing | Aerobic exercise reduces insulin concentrations and insulin resistance among patients with stage I-III colon cancer. | 29018055 |
| Malignant tumor of colon | Deregulated Nutrient Sensing | Prescribing 150 min/week of aerobic exercise may be sufficient for reducing insulin concentrations and insulin resistance, which may partially mediate the relationship between physical activity and colon cancer prognosis. | 29018055 |
| Dyslipidemias, Diabetes Mellitus, Heart Diseases, Tuberculosis, Pulmonary, Cerebrovascular accident, Hypertension, CTCAE | Deregulated Nutrient Sensing | Agreement was excellent for hypertension and diabetes, fair to good for stroke and heart disease, and poor for pulmonary tuberculosis and dyslipidemia. | 29020761 |
| Erectile dysfunction, Gout | Deregulated Nutrient Sensing | Insulin resistance is an independent predictor of erectile dysfunction in patients with gout. | 29020765 |
| Diabetic Nephropathy | Deregulated Nutrient Sensing | Extracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic Nephropathy. | 29020797 |
| Sedentary lifestyle, Obesity | Deregulated Nutrient Sensing | Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. | 29020958 |
| Heart failure, Cardiomyopathies | Deregulated Nutrient Sensing | We found that Akt-mTORC1 (mammalian target of rapamycin complex 1) signaling was increased, and treatment with 2.24 mg/kg*d rapamycin or 40% caloric restriction for 9 weeks partially rescued cardiomyopathy or heart failure and restored autophagic flux in knockin mice. | 29021349 |
| Drug abuse, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Using joinpoint regression, prevalence of hypertension increased annually by 1.4%, diabetes by 2%, dyslipidemia by 7%, smoking by 5%, and drug abuse by 7%. | 29021359 |
| Postmenopausal state | Deregulated Nutrient Sensing | Genetic variants and traits related to insulin-like growth factor-I and insulin resistance and their interaction with lifestyles on postmenopausal colorectal cancer risk. | 29023587 |
| melanoma | Deregulated Nutrient Sensing | Melanoma antigen A6 (MAGEA6)/TRIM28 complex is a cancer-specific ubiquitin ligase, which degradates tumor suppressor protein AMP-activated protein kinase (AMPK). | 29024810 |
| Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | MAGEA6 knockdown by targeted-shRNA in glioma cells restored AMPKa1 expression, causing mTORC1 in-activation and cell death/apoptosis. | 29024810 |
| methyldopa, Age related macular degeneration, Dyslipidemias, Unspecified visual loss | Deregulated Nutrient Sensing | Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. | 29025108 |
| Hypercholesterolemia, Glucose Intolerance (disease), Hypertriglyceridemia, Obesity | Deregulated Nutrient Sensing | Among Shors, the following factors increased AH risk: female sex, age, hypercholesterolemia, hyperbetacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), glucose intolerance, and the DD ACE, CT MTHFR, and AA ADRB1 genotypes; among the non-indigenous population, the main factors were age, hypercholesterolemia, hyperbetacholesterinemia, hypoalfacholesterinemia, hypertriglyceridemia, obesity (including transabdominal obesity), and ID ACE genotype. | 29027816 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Dietary advanced glycated end-products and medicines influence the expression of SIRT1 and DDOST in peripheral mononuclear cells from long-term type 1 diabetes patients. | 29027826 |
| Diabetic Nephropathy, Retinal Diseases | Deregulated Nutrient Sensing | Higher expressions of AGER, DDOST and SIRT1 were observed in Group A. Stratifying by complications, AGER and DDOST expressions were higher in those without retinopathy and without diabetic kidney disease, respectively, compared to patients with these complications. | 29027826 |
| Glycation End Products, Advanced | Deregulated Nutrient Sensing | Expression of SIRT1 was higher in patients consuming >=12,872 KU daily of advanced glycation end-products. | 29027826 |
| Refractory Cytopenia of Childhood, Primary malignant neoplasm, Dyslipidemias, Renal Cell Carcinoma Pathway | Deregulated Nutrient Sensing | Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). | 29029037 |
| Skeletal muscle structure | Deregulated Nutrient Sensing | Reduced skeletal muscle density in older adults is associated with insulin resistance, decreased physical function, and an increased all-cause mortality risk. | 29030163 |
| Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Patients with acute ischemic stroke and dyslipidemia randomly received statins within 24 hours after admission in the early group or on the seventh day in the delayed group, in a 1:1 ratio. | 29030478 |
| Disability, Dyslipidemias, Ischemic stroke | Deregulated Nutrient Sensing | Our randomized trial involving patients with acute ischemic stroke and dyslipidemia did not show any superiority of early statin therapy within 24 hours of admission compared with delayed statin therapy 7 days after admission to alleviate the degree of disability at 90 days after onset. | 29030478 |
| Steatohepatitis, Inflammation | Deregulated Nutrient Sensing | The outcome variables of interest were indicators of hepatic steatosis, liver enzymes, insulin resistance, inflammation and oxidative stress. | 29035092 |
| Arterial Stiffness, Dyslipidemias, Hypertension, CTCAE, Cardiovascular Diseases | Deregulated Nutrient Sensing | The influence of dyslipidemia might be via moderate arterial stiffness, which results in hypertension and cardiovascular disease. | 29035100 |
| ETV3 wt Allele | Deregulated Nutrient Sensing | Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. | 29037214 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | HP genetic variation may have utility as a biomarker of insulin resistance and diabetes risk in Arab-Americans, however, future prospective studies are needed. | 29039222 |
| Increased insulin level, Dyslipidemias | Deregulated Nutrient Sensing | He had hyperinsulinemia, dyslipidemia and grade 2 hepatosteatosis. | 29040067 |
| Prostate Cancer Outcomes Study, Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | PCOS is associated with insulin resistance and increased prevalence of prediabetes and Type 2 diabetes (T2D) which is closely linked to obesity and possibly age, ethnicity and PCOS phenotype. | 29040530 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The rates of hypertension and dyslipidemia were comparable between the two groups. | 29041913 |
| Refractory anemias, Inflammation, Rheumatoid Arthritis | Deregulated Nutrient Sensing | The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. | 29041949 |
| Obesity | Deregulated Nutrient Sensing | Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1. | 29042127 |
| Hypertension, CTCAE, Endothelial dysfunction | Deregulated Nutrient Sensing | Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension. | 29043342 |
| Dyslipidemias | Deregulated Nutrient Sensing | The patient was a chronic smoker and had dyslipidemia. | 29044080 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Despite this, PCOS subjects experienced steeper increases in cardiovascular risk factors associated with insulin resistance, including triglycerides and HOMA-IR. | 29044581 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Diagnosis of hypertension, dyslipidemia or diabetes mellitus was inclusion criterion. | 29045483 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | Autophagy induction enhances tetrandrine-induced apoptosis via the AMPK/mTOR pathway in human bladder cancer cells. | 29048631 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | Moreover, AICAR, a common AMPK activator, further increased the expression the LC3-II, while AMPK inhibitor compound C partially reversed the LC3-II protein levels in bladder cancer T24 cells. | 29048631 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | Finally, AICAR significantly reinforced the growth inhibition and apoptosis induction of tetrandrine in T24 and 5637 cells, while compound C had an opposite effect, suggesting that AMPK-mediated autophagy enhanced the cytotoxic and pro-apoptosis effect of tetrandrine in human bladder cancer cells. | 29048631 |
| Malignant neoplasm of urinary bladder, Primary malignant neoplasm | Deregulated Nutrient Sensing | Taken together, the present study showed that tetrandrine induced autophagy in human bladder cancer cells by regulating the AMPK/mTOR signaling pathway, which contributed to the apoptosis induction by tetrandrine, indicating that tetrandrine may be a potential anticancer candidate for the treatment of bladder cancer, and autophagy may be a possible mechanism for cancer therapy. | 29048631 |
| Atherosclerosis | Deregulated Nutrient Sensing | One of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP). | 29048932 |
| Squamous cell carcinoma, Neoplasms | Deregulated Nutrient Sensing | SIRT1 acts as a potential tumor suppressor in oral squamous cell carcinoma. | 29050728 |
| Neoplasms, SERPINB3 wt Allele | Deregulated Nutrient Sensing | SIRT1, has been considered a prominent tumor-suppressing/promoting gene in various solid tumors, although the precise role of SIRT1 in OSCC progression remains unknown. | 29050728 |
| SERPINB3 wt Allele | Deregulated Nutrient Sensing | SIRT1 levels in OSCC were determined, SIRT1 overexpression was achieved on transfecting OSCC cells with a SIRT1-containing plasmid, followed by evaluation of proliferative ability and invasiveness of these cells. | 29050728 |
| SERPINB3 wt Allele | Deregulated Nutrient Sensing | SIRT1 levels were significantly lower in patients with OSCC than in controls (p < 0.05). | 29050728 |
| SERPINB3 wt Allele | Deregulated Nutrient Sensing | Moreover, SIRT1 levels in patients with OSCC were significantly associated with the lymphovascular permeation but not with the sex, age, stage and location. | 29050728 |
| SERPINB3 wt Allele | Deregulated Nutrient Sensing | Furthermore, SIRT1 overexpression inhibited proliferation and invasion in OSCC cells. | 29050728 |
| Neoplasms, SERPINB3 wt Allele | Deregulated Nutrient Sensing | The present results suggest that SIRT1 is a potential tumor suppressor in OSCC. | 29050728 |
| Non-alcoholic Fatty Liver Disease, Osteopenia | Deregulated Nutrient Sensing | Analyses using a nationally representative cohort have revealed that high fatty liver index (FLI) is associated with low bone mineral density (BMD) regardless of insulin resistance in men, thereby supporting the deteriorated bone metabolism in nonalcoholic fatty liver disease (NAFLD). | 29051986 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | NAFLD is associated with low bone density regardless of insulin resistance in men. | 29051986 |
| Alzheimers Disease | Deregulated Nutrient Sensing | Insulin signalling deficiencies and insulin resistance have been directly linked to the progression of neurodegenerative disorders like Alzheimer's disease. | 29053786 |
| Tauopathies | Deregulated Nutrient Sensing | These results suggest that insulin retention in hyperphosphorylated tau-bearing neurons is a causative factor for the insulin resistance observed in tauopathies, and describe a novel neuropathological concept with important therapeutic implications. | 29053786 |
| Dyslipidemias, Cardiovascular event, Hypertension, CTCAE, Metabolic Syndrome X | Deregulated Nutrient Sensing | Univariate logistic regression analysis demonstrated that tobacco consumption (p < .05), serum total 25-hydroxyvitamin D (p < .01), serum endocan levels (p < .01), peak systolic velocity (p < .01), hypertension (p < .001), dyslipidaemia (p < .001), metabolic syndrome (p = .026) and a history of a cardiovascular event (p < .001) significantly increase the risk of severe ED. | 29057489 |
| Cardiovascular Diseases, Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Diabetes Mellitus, Malignant Neoplasms, Hypertension, CTCAE, Italy | Deregulated Nutrient Sensing | The proportion of patients in Italy and the USA diagnosed with >=1 NCD is estimated to increase from 64% and 71% in 2015 to 89% and 89% by 2035, respectively, driven by moderate cardiovascular disease (CVD) (hypertension and dyslipidaemia), diabetes and malignancies in both countries. | 29059202 |
| Hyperglycemia, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Importantly, a novel link between a risk factor profile comprising indices of obesity, hyperglycemia, dyslipidemia and diastolic BP and localized alterations in CT emerged. | 29062686 |
| Dyslipidemias | Deregulated Nutrient Sensing | The percentage of females with dyslipidaemia was higher than males (21.2% vs. 14.6%). | 29063802 |
| Dyslipidemias | Deregulated Nutrient Sensing | Higher adherence to Mediterranean diet was inversely associated with dyslipidaemia (OR: 0.56, 95% Cl: 0.36, 0.86). | 29063802 |
| Fatty Liver Disease | Deregulated Nutrient Sensing | Adherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease: Effect on Insulin Resistance. | 29063908 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Among NAFLD patients, good adherence to Med-Diet was associated with lower insulin resistance. | 29063908 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Dyslipidemias | Deregulated Nutrient Sensing | We included 584 consecutive outpatients presenting with one or more cardiovascular risk factor such as type 2 diabetes mellitus (T2DM), arterial hypertension, overweight/obesity, and dyslipidemia. | 29063908 |
| ARCN1 gene, ETV3 wt Allele | Deregulated Nutrient Sensing | Finally, a negative association emerged between smoking and vitamin D. We have estimated, for the first time, the COPD prevalence in MetS and suggest a potential role of smoking in inducing insulin resistance. | 29065130 |
| ARCN1 gene | Deregulated Nutrient Sensing | Moreover, a direct effect of smoking on vitamin D levels is proposed as a novel mechanism, which may account for both insulin resistance and COPD development. | 29065130 |
| Diabetes Mellitus, Atherosclerosis | Deregulated Nutrient Sensing | Adipose tissue, an endocrine organ of the body, is involved in some obesity-related disease states such as insulin resistance, diabetes mellitus, and atherosclerosis. | 29065866 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Inflammatory disorder | Deregulated Nutrient Sensing | Type 2 Diabetes Mellitus (T2DM), which often accompanies dyslipidemia, is considered an inflammatory disease. | 29066482 |
| Dyslipidemias | Deregulated Nutrient Sensing | Association of vitamin D receptor gene polymorphisms with diabetic dyslipidemia in the elderly male population in North China. | 29066872 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The prevalence of dyslipidemia is rising alarmingly in elderly Han Chinese male patients with type 2 diabetes mellitus (T2DM). | 29066872 |
| Dyslipidemias | Deregulated Nutrient Sensing | The genetic factors that contribute to the development of diabetic dyslipidemia remain incompletely identified. | 29066872 |
| Dyslipidemias | Deregulated Nutrient Sensing | These findings suggest that CC genotype of VDR-FokI is a risk factor for T2DM patients with dyslipidemia in elderly males in North China. | 29066872 |
| Hyperinsulinism, Dyslipidemias | Deregulated Nutrient Sensing | Visceral accumulation of body fat is particularly disadvantageous when it is correlated with insulin resistance, secondary hyperinsulinaemia, dysglicaemia, and atherogenic dyslipidemia. | 29068599 |
| Arthralgia, Noncommunicable Diseases, Dyslipidemias, Diabetes Mellitus, Hepatobiliary Disorder, Thyroid dysfunction, Morbid obesity, Lung diseases, Hypertension, CTCAE | Deregulated Nutrient Sensing | Incidences of non-communicable diseases (diabetes, hypertension, dyslipidemia, liver disease, lung disease, thyroid dysfunction, and joint pain) were increased in women with morbid obesity. | 29069258 |
| AHSG protein, human, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic Syndrome X | Deregulated Nutrient Sensing | Fetuin-A is a physiological inhibitor of insulin receptor tyrosine kinase and thus associated with insulin resistance, metabolic syndrome, and an increased risk for type 2 diabetes mellitus (T2DM). | 29071522 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Insulin resistance can lead to the pathogenesis of type 2 diabetes and exercise can increase insulin sensitivity. | 29072034 |
| Parkinson Disease | Deregulated Nutrient Sensing | Amnestic dementia impairment in Parkinson's disease: The role of body composition, ageing and insulin resistance. | 29072169 |
| Presenile dementia | Deregulated Nutrient Sensing | To investigate body mass distribution, insulin resistance, and other parameters in patients without dementia, and those with dementia classified as compromised delayed memory. | 29072169 |
| palladium, Impaired cognition | Deregulated Nutrient Sensing | The results of this study indicate an apparent decrease in insulin resistance associated with cognitive impairment in PD. | 29072169 |
| Fatty Liver, Increased insulin level, Obesity | Deregulated Nutrient Sensing | When placed on a 12-week high-fat diet (HFD), Casp2-/- mice resisted the development of obesity, fatty liver, hyperinsulinemia and insulin resistance. | 29072701 |
| Non-alcoholic Fatty Liver Disease, Metabolic Syndrome X, Nephrolithiasis | Deregulated Nutrient Sensing | Non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation or precursor of metabolic syndrome, may increase nephrolithiasis, a renal manifestation of insulin resistance, but the prospective association between NAFLD and incident nephrolithiasis has not been evaluated. | 29073130 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Degree of ketonaemia and its association with insulin resistance after dapagliflozin treatment in type 2 diabetes. | 29074329 |
| Hypokalemia, Hyperglycemia, Paralysed | Deregulated Nutrient Sensing | This transient paralysis is possibly caused by the effects of glucocorticoids on Na-K channels and insulin resistance resulting in hyperglycemia and subsequent hypokalemia. | 29074369 |
| Postmenopausal state | Deregulated Nutrient Sensing | Genetic variants in the insulin-like growth factor-I (IGF-I)/insulin resistance axis may interact with lifestyle factors, influencing postmenopausal breast cancer risk, but these interrelated pathways are not fully understood. | 29074537 |
| Metabolic Syndrome X | Deregulated Nutrient Sensing | Both C-reactive protein serum concentration and insulin resistance increased in the metabolic syndrome patients. | 29077157 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Multivariate logistic regression analyses showed that being overweight was predictive of dyslipidemia (OR 1.76; 95%CI 1.51-2.05, p<0.001) and dyslipidemia awareness (OR 2.58; 95%CI 1.19-5.58; p = 0.017). | 29077762 |
| Vascular Diseases, Hyperglycemia, Dyslipidemias, Obesity, Hypertension, CTCAE | Deregulated Nutrient Sensing | Determinants (age, sex, hypertension, dyslipidemia, hyperglycemia, obesity, and smoking) of macrovascular diseases affect large-artery endothelial function. | 29077770 |
| Dyslipidemias | Deregulated Nutrient Sensing | Of 734 patients, 31 (4.2%) received statins for dyslipidemia (statin group) and 703 (95.8%) did not (non-statin group). | 29081488 |
| Hypertension, CTCAE | Deregulated Nutrient Sensing | Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. | 29082259 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Muscular fitness, measured by handgrip strength, is associated with insulin resistance and glucose metabolism in adolescents, which indicates that increasing muscular fitness may have beneficial effects for early prevention of insulin resistance and type 2 diabetes. | 29082590 |
| Thyroid carcinoma, Thyrotoxicosis | Deregulated Nutrient Sensing | This study shows for the first time that subclinical thyrotoxicosis in patients with thyroid cancer is associated with insulin resistance, as measured by hyperinsulinemic-euglycemic clamp technique. | 29083246 |
| Cerebrovascular accident | Deregulated Nutrient Sensing | Pioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke). | 29084736 |
| Electrocardiogram: myocardial infarction (finding), Cerebrovascular accident | Deregulated Nutrient Sensing | The IRIS trial (Insulin Resistance Intervention after Stroke) demonstrated that pioglitazone reduced the risk for a composite outcome of stroke or myocardial infarction among nondiabetic patients with insulin resistance and a recent stroke or transient ischemic attack. | 29084736 |
| Ischemic stroke | Deregulated Nutrient Sensing | Pioglitazone was effective for secondary prevention of ischemic stroke in nondiabetic patients with insulin resistance. | 29084736 |
| Dyslipidemias, Hyperglycemia, Obesity, Abdominal, Hypertension, CTCAE | Deregulated Nutrient Sensing | The management of cardiometabolic risk factors, such as abdominal obesity, dyslipidemia, hypertension, and hyperglycemia, is essential for the health of postmenopausal women. | 29094434 |
| Dyslipidemias | Deregulated Nutrient Sensing | The main demographic, clinical and vascular risk parameters were comparable between the two groups except for duration of the disease, prevalence of dyslipidemia and use of lipid-lowering drugs (significantly higher in the inducers group) and number of previous antiepileptic drugs (significantly higher in the non-inducers group). | 29096133 |
| Dyslipidemias, Cyclophosphamide/Vincristine/Dacarbazine Regimen, Atherosclerosis, Cardiovascular Diseases | Deregulated Nutrient Sensing | Dyslipidemia is a well-known risk factor for atherosclerosis and subsequent cardiovascular disease (CVD). | 29096835 |
| Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Prospective crossover study for a standardized comparison of the dextrane sulfate whole blood and plasma apheresis system in patients with cardiovascular disease and severe dyslipidemia. | 29096869 |
| Inflammation, Atherosclerosis | Deregulated Nutrient Sensing | Inflammation plays a key role in the development of insulin resistance and atherosclerosis. | 29098425 |
" | Dyslipidemias, Hypertension, CTCAE, Arteriopathic disease | Deregulated Nutrient Sensing | History of coronary
artery disease, dyslipidemia, and hypertension were higher in the older group. | 29099157 | "
| Dyslipidemias, Diabetes Mellitus, Cerebrovascular accident, Tacca leontopetaloides, Obesity, Overweight | Deregulated Nutrient Sensing | In private settings, patients had a higher educational level, a major frequency of dyslipidemia, a previous stroke and TIA, less overweight and obesity, a sedentary lifestyle, and diabetes; stroke severity, the rate of systemic complications, the length of stay, and in-hospital mortality were also lower; a major frequency of thrombolysis was observed when compared with public hospitals. | 29103861 |
| Diabetes Mellitus, Non-Insulin-Dependent, Atherosclerosis | Deregulated Nutrient Sensing | Neighborhood price of healthier food relative to unhealthy food and its association with type 2 diabetes and insulin resistance: The multi-ethnic study of atherosclerosis. | 29106915 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | This study examined the association between the price of healthier food relative to unhealthy food and type 2 diabetes prevalence, incidence and insulin resistance (IR). | 29106915 |
| Obesity | Deregulated Nutrient Sensing | To investigate the associations between irisin and leptin levels in obesity and insulin resistance in a cross sectional study. | 29108900 |
| Gestational Diabetes, Pregnancy Complications, Obesity | Deregulated Nutrient Sensing | Obesity is common in young women, increasing insulin resistance (IR) and worsening pregnancy complications, including gestational diabetes (GDM). | 29110650 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | We hypothesised that lower HRV is differentially associated with measures of insulin resistance and insulin secretion in recent-onset type 1 and type 2 diabetes. | 29113812 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Insulin resistance may contribute to the development of early cardiovagal suppression rather than sympathetic predominance in both diabetes types, while in type 1 diabetes a lower glucagon-stimulated insulin secretion is linked to a possibly compensatory higher parasympathetic tone. | 29113812 |
| Canada | Deregulated Nutrient Sensing | Whether interventions aimed at reducing insulin resistance could also reduce the risk of CAN remains to be established. | 29113812 |
| Acanthosis Nigricans, Obesity | Deregulated Nutrient Sensing | Laparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans. | 29115953 |
| Acanthosis Nigricans | Deregulated Nutrient Sensing | This study is aimed to observe the effect of laparoscopic sleeve gastrectomy (LSG) on body composition and insulin resistance in Chinese obese patients with acanthosis nigricans. | 29115953 |
| Loss of facial adipose tissue | Deregulated Nutrient Sensing | Patients with AN got noticeable improvement in skin condition and their AN score was significantly decreased (3.52 +- 0.79 vs. 1.48 +- 0.73, P < 0.001).Alleviated insulin resistance and more trunk fat loss than limbs' were observed in both groups (P value < 0.01). | 29115953 |
| Glucose Intolerance (disease), Unclassified Hepatocellular Adenoma | Deregulated Nutrient Sensing | Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. | 29116626 |
| Sarcopenia | Deregulated Nutrient Sensing | Sarcopenia and insulin resistance are common co-morbidities in the elderly and are known to be associated with vitamin D deficiency. | 29120677 |
| Sarcopenia, Obesity | Deregulated Nutrient Sensing | There was also a significant association between sarcopenia and insulin resistance, independent of vitamin D and obesity status (p < 0.0001). | 29120677 |
| Sarcopenia | Deregulated Nutrient Sensing | In the subgroup analysis, insulin resistance was found to be determined by sarcopenic rather than vitamin D status. | 29120677 |
| Sarcopenia, Obesity | Deregulated Nutrient Sensing | Sarcopenia was associated with both insulin resistance and 25-hydroxyvitamin D concentration in postmenopausal Korean women, regardless of obesity status. | 29120677 |
| Sarcopenia | Deregulated Nutrient Sensing | Sarcopenia is therefore of greater clinical importance due to its close relationship with insulin resistance. | 29120677 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Dyslipidaemia in a Black African diabetic population: burden, pattern and predictors. | 29121994 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | This study sought to assess the burden, pattern and predictors of dyslipidaemia in 425 adult diabetic patients in Uganda. | 29121994 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus | Deregulated Nutrient Sensing | Collectively, the predictors of dyslipidaemia were: female gender, study site (private hospitals), type of diabetes (type 2 diabetes mellitus), statin therapy, increased body mass index and diastolic blood pressure. | 29121994 |
| Dyslipidemias, diabetic | Deregulated Nutrient Sensing | Proactive screening of dyslipidaemia and its optimal management using lipid lowering therapy should be emphasised among adult diabetic patients in Uganda. | 29121994 |
| Dyslipidemias | Deregulated Nutrient Sensing | The association between AVNFH and dyslipidaemia remains controversial. | 29126401 |
| Femoral Neck Fractures, Dyslipidemias | Deregulated Nutrient Sensing | Our purpose herein was to evaluate the association between dyslipidaemia and AVNFH following low-energy femoral neck fractures treated with cancellous screws in elderly patients in our tertiary care centre. | 29126401 |
| Hypertension, CTCAE, Dyslipidemias, Cardiovascular Diseases | Deregulated Nutrient Sensing | Cardiovascular diseases are mainly related to hypertension and dyslipidemia and increase with aging because of the larger time span for these risk factors to damage arterial blood vessels. | 29128438 |
| Weight Gain | Deregulated Nutrient Sensing | Further studies to investigate the effect of sleep curtailment on weight gain through stress and insulin resistance are necessary. | 29129611 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | At least three cardiovascular risk factors were found in 46% of patients, with the most common dyslipidaemia (77.4%) and abdominal obesity (74.8%). | 29131289 |
| Dyslipidemias, Overweight, Obesity | Deregulated Nutrient Sensing | No significant difference was found in overweight, obesity, or dyslipidemia. | 29132553 |
| Infarction, Demographics Domain | Deregulated Nutrient Sensing | However, few studies have focused on the prognostic value of glycosylated hemoglobin (HbA1c) and Homeostatic Model Assessment 2 for Insulin Resistance (HOMA2-IR) in patients with DM, non-ST-segment elevation infarction (NSTEMI), and single concomitant chronic total occlusion (CTO) following primary percutaneous coronary intervention (PCI). | 29137017 |
| Dyslipidemias | Deregulated Nutrient Sensing | With the increase of serum 25(OH) D3 levels, the incidence of dyslipidemia decreased. | 29137635 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Patients with SMI had higher rates of diabetes, hypertension, and dyslipidemia. | 29138173 |
| Dyslipidemias, Cardiovascular Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | The proportion of visits by HIV-infected versus HIV-uninfected adults with aspirin/antiplatelet therapy when patients met guideline-recommended criteria for primary prevention or had cardiovascular disease was 5.1% versus 13.8% (P=0.03); the proportion of visits with statin therapy when patients had diabetes mellitus, cardiovascular disease, or dyslipidemia was 23.6% versus 35.8% (P<0.01). | 29138182 |
| ARCN1 gene | Deregulated Nutrient Sensing | SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients. | 29138552 |
| ARCN1 gene, Inflammation | Deregulated Nutrient Sensing | Longevity gene, SIRT1, is reported to be involved in the pathogenesis of COPD by regulating the signaling pathways of oxidative stress, inflammation, and aging. | 29138552 |
| ARCN1 gene | Deregulated Nutrient Sensing | We hypothesize that SIRT1 and related genes are also associated with the benefits of PA in COPD patients. | 29138552 |
| Obesity, Abdominal, Dyslipidemias | Deregulated Nutrient Sensing | We performed an 18-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. | 29142011 |
| Somatotropin deficiency | Deregulated Nutrient Sensing | Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. | 29143180 |
| Hypercholesterolemia, Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The first is to estimate the prevalence of dyslipidaemia (hypercholesterolaemia, hypertriglyceridaemia, high low-density lipoprotein (LDL) level and low high-density lipoprotein (HDL) level), as well as the mean levels of total cholesterol, triglyceride, LDL and HDL, in the urban and rural Yangon Region, Myanmar. | 29146640 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | Knockdown of SIRT1 Suppresses Bladder Cancer Cell Proliferation and Migration and Induces Cell Cycle Arrest and Antioxidant Response through FOXO3a-Mediated Pathways. | 29147649 |
| Metabolic Diseases, Neoplasms | Deregulated Nutrient Sensing | SIRT1 is a key member of Sirtuins, playing important roles in aging and energy metabolism, which has been reported to be involved in various metabolic diseases and tumors. | 29147649 |
| Dyslipidemias, Prediabetes syndrome, Hypertension, CTCAE, Osage language | Deregulated Nutrient Sensing | Thirty-two percent of mild OSA patients had MS, 43.5% of mild OSA patients had hypertension, 14% showed dyslipidemia, and 56% had prediabetes. | 29148894 |
| Pancreatitis | Deregulated Nutrient Sensing | Although the IFALD improved, he had signs of insulin resistance and struggled with numerous episodes of pancreatitis. | 29148930 |
| Obesity | Deregulated Nutrient Sensing | Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance. | 29150224 |
| Obesity | Deregulated Nutrient Sensing | SIRT1 and SIRT2 expression and AMPK levels decrease in children with obesity and IR. | 29150224 |
| Lipolysis, Adipocyte hypertrophy, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. | 29153750 |
| Adipocyte hypertrophy, Diabetes Mellitus | Deregulated Nutrient Sensing | Also, 24% of probands had a family history of diabetes, which was associated with higher body mass index (BMI) scores, and more insulin resistance (HOMAIR) and adipose hypertrophy. | 29153750 |
| Steatohepatitis, FETUB gene, Diabetes Mellitus | Deregulated Nutrient Sensing | Fetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis. | 29153939 |
| Weight decreased | Deregulated Nutrient Sensing | Role of rs1501299 variant in the adiponectin gene on total adiponectin levels, insulin resistance and weight loss after a Mediterranean hypocaloric diet. | 29154912 |
| Sleep-Disordered Breathing, Dyslipidemias, Hypertension, CTCAE, GDC Comorbidity Terminology | Deregulated Nutrient Sensing | Dyslipidemia, sleep-disordered breathing (SDB) and hypertension are comorbid factors evidenced in adults, but poorly studied in old people. | 29157582 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The prevalence of high-risk dyslipidemia decreased from 61.3 to 44.4%, and hypertension from 57.9 to 27.4%. | 29157582 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Effects of hepato-preferential basal insulin peglispro on nuclear magnetic resonance biomarkers lipoprotein insulin resistance index and GlycA in patients with diabetes. | 29160108 |
| Increased insulin level, Metabolic Diseases | Deregulated Nutrient Sensing | We conclude that in obese, older and sedentary men, acute exercise modifies skeletal muscle mitochondrial respiration and H2O2 emission responses to hyperinsulinemia in a respiratory state-specific manner, which may have implications for metabolic diseases involving insulin resistance. | 29161316 |
| Hypertensive disease | Deregulated Nutrient Sensing | Furthermore, rs13175330 G allele carriers in the HTN w/o therapy group had significantly increased levels of insulin, insulin resistance, and oxidized low-density lipoprotein (LDL) and significantly decreased LDL-cholesterol levels and LDL particle sizes compared to the AA carriers. | 29162152 |
| Hypertensive disease | Deregulated Nutrient Sensing | Additionally, the PAM rs13175330 G allele might be associated with insulin resistance and LDL atherogenicity in patients with HTN. | 29162152 |
| Cerebral Small Vessel Diseases, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia predicts higher risk of coronary events and stroke and might be associated with cerebral small vessel disease (SVD). | 29162363 |
| Inflammation, Obesity | Deregulated Nutrient Sensing | Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. | 29166392 |
| Glucose Intolerance (disease), Ralstonia pickettii, Obesity | Deregulated Nutrient Sensing | Intestinal Ralstonia pickettii augments glucose intolerance in obesity. | 29166392 |
| Dyslipidemias, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Statin users had a high prevalence of obesity and diabetes, as well as dyslipidemia. | 29167018 |
| Colorectal Carcinoma | Deregulated Nutrient Sensing | Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production. | 29167573 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most transferable processes concerned health maintenance (32.1%) and cardiovascular risk factors (hypertension (28.7%), dyslipidaemia (25.3%) and diabetes (24.3%)). | 29170284 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling. | 29174979 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Ubiquitin-specific peptidase 22 (USP22) is upregulated in NSCLC and promotes tumorigenesis via a Sirt1-JAK-STAT3 pathway. | 29174979 |
| Non-Small Cell Lung Carcinoma | Deregulated Nutrient Sensing | Taken together, these findings suggest that miR-30e-5p suppresses NSCLC tumorigenesis by downregulatingUSP22-mediated Sirt1/JAK/STAT3 signaling. | 29174979 |
| Malignant neoplasm of urinary bladder | Deregulated Nutrient Sensing | TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARg-SIRT1 feedback loop in human bladder cancer cells. | 29175458 |
| Hepatotoxicity, Dyslipidemias | Deregulated Nutrient Sensing | Although clinical investigation of LY2584702 has been terminated because of hepatotoxicity risk, we suggest that a selective inhibitor of p70 S6 serine/threonine protein kinase-1 with a larger margin of safety and without the possibility of being metabolized to 4-APP may be useful in the treatment of dyslipidemia. | 29178617 |
| Inflammation, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Obesity-induced inflammation engenders insulin resistance and type 2 diabetes mellitus (T2DM) but the inflammatory effectors linking obesity to insulin resistance are incompletely understood. | 29180649 |
| Obesity | Deregulated Nutrient Sensing | Hepatic PTPR-g overexpression that mimics levels found in obesity is sufficient to cause severe hepatic and systemic insulin resistance. | 29180649 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | Individuals who were overweight/obesity, with dyslipidemia, or diabetes were at a higher risk of hypertension; these people also more likely to be aware of their condition. | 29180804 |
| Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | Moreover, dyslipidemia (OR = 0.600; 95% CI: 0.375, 0.960) were associated with poor hypertension control. | 29180804 |
| Hyperglycemia, Dental Plaque | Deregulated Nutrient Sensing | Fasting plasma glucose, 2 h postprandial glucose and Homeostasis model assessment of insulin resistance, triglycerides, plaque were significantly higher in the hyperglycemia group than non-hyperglycemia. | 29183105 |
| Dysglycemia | Deregulated Nutrient Sensing | In adolescents with dysglycemia, there was marked insulin resistance (insulin sensitivity index: adolescents, median [interquartile range] 1.8 [1.1-2.4] x 10-4; adults, 5.0 [2.3-9.9]; P = 0.01). | 29183909 |
| hearing impairment, Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | Dyslipidemia as a Potential Moderator of the Association between Hearing Loss and Depressive Symptoms. | 29188892 |
| hearing impairment, Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | We investigated dyslipidemia as a potential moderator of the association between hearing/hearing loss and depressive symptoms. | 29188892 |
| hearing impairment, Dyslipidemias, Bipolar Disorder | Deregulated Nutrient Sensing | The findings provide some support for moderation of the association between hearing/hearing loss and depressive symptoms by dyslipidemia, with important lipid-specific and hearing measure-specific differences. | 29188892 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | The most common comorbidities were hypertension (82.0%) and dyslipidaemia (76.6%). | 29188902 |
| Inflammation, Bipolar Disorder | Deregulated Nutrient Sensing | The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women. | 29190710 |
| Inflammation, Depression, CTCAE | Deregulated Nutrient Sensing | Depression has been shown to be associated with elevated leptin levels, low-grade inflammation and insulin resistance. | 29190710 |
| Hypertension, CTCAE, Albuminuria, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | So we determined the adequacy of control of the modifiable risk factors: glycaemic control, hypertension, dyslipidemia, obesity and albuminuria in the study patients from rural and peri-urban dwelling. | 29191193 |
| Albuminuria, Cardiovascular morbidity, Dyslipidemias, Obesity, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is associated with substantial cardiovascular morbidity and mortality arising from the high prevalence of cardiovascular risk factors such as hypertension, dyslipidaemia, obesity, poor glycaemic control and albuminuria. | 29191193 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Patients with older age, hypertension and dyslipidemia as well as those who smoked were at higher risk of developing LEAD. | 29191431 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Empagliflozin decreases remnant-like particle cholesterol in type 2 diabetes patients with insulin resistance. | 29193767 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | EMPA decreases RLP-C levels, which is closely associated with amelioration of insulin sensitivity in diabetes patients who have insulin resistance. | 29193767 |
| Carotid Atherosclerosis, Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Besides traditional risk factors, such as dyslipidemia, smoking, obesity, and carotid atherosclerosis, novel factors are under investigation such as genetic polymorphisms. | 29196930 |
| Electrocardiogram: myocardial infarction (finding), Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Malaysian/Bruneian patients had lower rates of myocardial infarction (54.55% versus 59.76%, p=0.033) and higher rates of diabetes (43.24% versus 28.99%, p<0.001) and dyslipidaemia (90.42% versus 74.66%, p<0.001) compared with the RoW. | 29197883 |
| Dyslipidemias, Malignant Neoplasms, Obesity | Deregulated Nutrient Sensing | Obesity, which is commonly accompanied by dyslipidemia, is associated with an increased risk of certain cancers. | 29197994 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Omentin-1 might play a role on insulin resistance, dyslipidemia and obesity. | 29198435 |
| Dyslipidemias, Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases | Deregulated Nutrient Sensing | The morbidity of cardiovascular disease in patients with type 2 diabetes mellitus (DM) deteriorates in combination with dyslipidemia. | 29199201 |
| Hyperglycemia, Dyslipidemias | Deregulated Nutrient Sensing | The current study investigated whether the dipeptidyl peptidase-4 inhibitor sitagliptin ameliorates dyslipidemia and hyperglycemia. | 29199201 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction. | 29200598 |
| Refractory anemias, Inflammation | Deregulated Nutrient Sensing | The group of patients with RA patients presented inflammation, low levels of vitamin D, elevated insulin resistance, and reduced flow-mediated vasodilation, statistically significant compared to the control group (p < 0.00001). | 29200598 |
| Refractory anemias, Endothelial dysfunction | Deregulated Nutrient Sensing | In early RA patients with moderate and high disease activity, low serum levels of vitamin D were associated with disease activity, increased insulin resistance, and endothelial dysfunction. | 29200598 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Androgen receptor CAG repeat polymorphism is not associated with insulin resistance and diabetes among South Asian males. | 29202793 |
| Prostate Cancer Outcomes Study, Glucose Intolerance (disease), Diabetes Mellitus | Deregulated Nutrient Sensing | These data suggest that routine screening for diabetes in prevention strategies does not need to be emphasized for PCOS patients at late reproductive ages if they have not been affected by glucose intolerance up to that point. | 29202960 |
| Atherosclerosis, Coronary heart disease | Deregulated Nutrient Sensing | Effect of pioglitazone on insulin resistance, progression of atherosclerosis and clinical course of coronary heart disease. | 29203734 |
| Atherosclerosis, Coronary heart disease, Choline Dehydrogenase, Mitochondrial | Deregulated Nutrient Sensing | Our aim was to study the effect of pioglitazone on insulin resistance, the clinical course of atherosclerosis and coronary heart disease (CHD). | 29203734 |
| Atherosclerosis, Coronary heart disease | Deregulated Nutrient Sensing | Long-term treatment with pioglitazone at low doses against the background of standard therapy contributes to functional and clinical condition of patients, promotes the prevention of atherosclerosis and reduction of insulin resistance, thereby improving the clinical manifestations of coronary heart disease. | 29203734 |
| Adult Glioblastoma | Deregulated Nutrient Sensing | FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain. | 29207098 |
| Glioblastoma Multiforme Pathway | Deregulated Nutrient Sensing | Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. | 29207163 |
| Dyslipidemias, Hypertension, CTCAE, Diabetes Mellitus | Deregulated Nutrient Sensing | These cutoff levels for NC were associated with a significantly increased risk for diabetes, dyslipidemia, and hypertension. | 29209671 |
| Dyslipidemias, Dysglycemia, Obesity | Deregulated Nutrient Sensing | Those attending a screening visit with any 3 or more risk factors of central obesity, dyslipidemia (high triglycerides or low high density lipoprotein cholesterol) elevated blood pressure and dysglycemia were randomized to either nurse-led health and lifestyle modification (intervention) or standard care (control). | 29212477 |
| Obesity | Deregulated Nutrient Sensing | WHtR showed stronger associations with measures of insulin resistance and truncal obesity than WHR. | 29214673 |
| Transient Ischemic Attack | Deregulated Nutrient Sensing | Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response. | 29215310 |
| Stomach Carcinoma | Deregulated Nutrient Sensing | Gastric cancer surgery led to decreased ghrelin and leptin and increased PYY and GIP, which might have a role in improving insulin resistance and glucose homeostasis. | 29216250 |
| Dyslipidemias | Deregulated Nutrient Sensing | The combination of GLP-1RAs and statins may be a reasonable therapeutic option in T2DM with dyslipidemia. | 29217412 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Preventing dyslipidaemia and diabetes in South Asians may therefore help reduce their excess risk of CVD. | 29217719 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The problem of dyslipidemia is high in patients with diabetes mellitus. | 29217920 |
| Dyslipidemias, Demographics Domain, Atherosclerosis, Coronary heart disease | Deregulated Nutrient Sensing | Thus, DM patients are more prone to dyslipidemia which is an important risk factor for atherosclerosis and coronary heart disease. | 29217920 |
| Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although white blood cell and C-reactive protein are associated with adiposity and insulin resistance, these inflammatory markers also independently predict type 2 diabetes and/or hypertension. | 29221802 |
| Adrenal Cortex Hormones | Deregulated Nutrient Sensing | In U937 cells, treatment with quercetin activated AMPK and induced expression of nuclear factor erythroid 2-related factor 2, and consequently reversed CSE-induced corticosteroid insensitivity. | 29227717 |
| Hyperglycemia, Dyslipidemias, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Hyperglycaemia co-morbidity with dyslipidaemia (5.0%), obesity (3.1%) and hypertension (1.8%) were observed. | 29228975 |
| Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | Dyslipidemia in Children With Arterial Ischemic Stroke: Prevalence and Risk Factors. | 29229232 |
| Dyslipidemias, Ischemic stroke, Cerebrovascular accident | Deregulated Nutrient Sensing | We performed a cross-sectional analysis of lipid and Lp(a) concentrations in children with arterial ischemic stroke in the International Pediatric Stroke Study to compare the prevalence of dyslipidemia and high- or low-ranking lipid values in our dataset with reported population values. | 29229232 |
| Hypertriglyceridemia, Dyslipidemias, Cerebrovascular accident | Deregulated Nutrient Sensing | We analyzed sex, body mass index, race, ethnicity, family history, and stroke risk factors for associations with dyslipidemia, high non-high-density lipoprotein cholesterol, and hypertriglyceridemia. | 29229232 |
| Dyslipidemias, Overweight | Deregulated Nutrient Sensing | Dyslipidemia was more likely associated with an underweight, overweight, or obese body mass index compared with a healthy weight. | 29229232 |
| Hypertriglyceridemia, Ischemic stroke, Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia and hypertriglyceridemia may be more prevalent in children with arterial ischemic stroke compared with stroke-free children. | 29229232 |
| Hypertension, CTCAE, Overweight, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Morbidly obese patients had a higher rate of hypertension, dyslipidemia, and diabetes mellitus compared with normal or overweight patients. | 29232296 |
| Lipodystrophy, hormone-sensitive lipase activity | Deregulated Nutrient Sensing | Mechanistic study revealed that deficiency of HSL in adipose tissue caused inflammatory macrophage infiltrates, progressive lipodystrophy, abnormal adipokine secretion and systemic insulin resistance. | 29232702 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | They often had associated comorbidities (coinfection HCV/HVB 40.5%, smoking 45.8%; hypertension 33.4%, dyslipidemia 28.8%, diabetes 14.8%). | 29233572 |
| Diabetes Mellitus | Deregulated Nutrient Sensing | Our data suggest that age and apparent 11b-HSD2 activity modulate the association of copeptin with insulin resistance at the population level but not MeTS or diabetes. | 29235050 |
| Increased insulin level, insulinoma, Neoplasms | Deregulated Nutrient Sensing | We also show that in response to chronic hyperinsulinemia, patients with insulinoma develop protective mechanisms responsible for a marked insulin resistance, which is reversible after complete resection of the tumour. | 29241949 |
| Acute Coronary Syndrome, Dyslipidemias | Deregulated Nutrient Sensing | Compared with younger patients, octogenarians smoked and had dyslipidemia less often, and presented more frequently with acute coronary syndrome. | 29243834 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia may influence strongly before puberty and in late adolescence when plasma levels are naturally highest. | 29245288 |
| TG gene, Dyslipidemias | Deregulated Nutrient Sensing | Isolated high TG (normal LDL + normal HDL+ high TG) was most common type of combined dyslipidemia for female elderly (22.2%), female nonelderly (23.2%) and male elderly (24.1%) patients. | 29246160 |
| Dyslipidemias | Deregulated Nutrient Sensing | Dyslipidemia is more prevalent in the non-elderly than in the elderly for males. | 29246160 |
| Primary malignant neoplasm, Dyslipidemias, Diabetes Mellitus, Heart Diseases, Cerebrovascular accident, Chronic lung disease, Arthritis, Hypertension, CTCAE | Deregulated Nutrient Sensing | Self-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. | 29247088 |
| Deficit, Cessation of life, Kidney Failure, Congestive heart failure | Deregulated Nutrient Sensing | Multivariable analyses identified base deficit, intubation, congestive heart failure, dyslipidemia/statin use, and renal failure as predictors of operative death. | 29249502 |
| myocardial injury | Deregulated Nutrient Sensing | Perioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of AMPK. | 29250545 |
| Dyslipidemias, Ulcer | Deregulated Nutrient Sensing | Dyslipidemia (p=0.04), ESD procedure time (p=0.003) and artificial ulcer size (p<0.001) were identified as risk factors for delayed healing, with location in the lower third of the stomach [Odds ratio (OR) 6.76; p=0.016] and artificial ulcer size (OR, 1.18; p=0.024) retained as independent risk factors. | 29253050 |
| Dyslipidemias | Deregulated Nutrient Sensing | Pioglitazone attenuates cardiometabolic risk factors in non-diabetic patients with dyslipidemia. | 29256535 |
| Dyslipidemias | Deregulated Nutrient Sensing | To determine the effect of pioglitazone on cardiometabolic risk factors in non-diabetic patients with dyslipidaemia. | 29256535 |
| Dyslipidemias | Deregulated Nutrient Sensing | This prospective, randomised clinical trial was conducted at Sheikh Zayed Medical College and Hospital, Rahim Yar Khan, Pakistan, from August to October 2016, and comprised non-diabetic patients with dyslipidaemia. | 29256535 |
| Inflammation, Diabetes Mellitus, Non-Insulin-Dependent, ETV3 wt Allele, Atherosclerosis | Deregulated Nutrient Sensing | Yet, the clinical criteria for MetS are insensitive to the early-stage insulin resistance, inflammation, cholesterol and clotting factor abnormalities that characterize the progression toward type 2 diabetes and atherosclerosis. | 29258604 |
| Increased insulin level, Dyslipidemias, Inflammation | Deregulated Nutrient Sensing | After correcting for confounders, low water T2 values were independently and additively associated with fasting hyperinsulinemia, dyslipidemia and subclinical inflammation. | 29258604 |
| Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | We detected high-order interactions between dyslipidemia, GRS, smoking status, age and diabetes. | 29258680 |
| Hyperlipidemia, Dyslipidemias | Deregulated Nutrient Sensing | Evaluation of dyslipidaemia and the impact of hypolipidemic therapy on prognosis in high and very high risk patients through the Hyperlipidaemia Therapy in tERtiary Cardiological cEnTer (TERCET) Registry. | 29258913 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | GlycA was higher among older, women, smokers, alcohol abstemious, obese and in those with diabetes, hypertension or dyslipidemia. | 29262791 |
| Hypertension, CTCAE, Cardiovascular Diseases, Hand | Deregulated Nutrient Sensing | As adults age with HIV, they are more likely to develop comorbidities such as cardiovascular disease, hypertension, and insulin resistance that may further contribute to poorer cognitive functioning and HAND. | 29266286 |
| Hypertension, CTCAE, Dyslipidemias, Gout | Deregulated Nutrient Sensing | Co-morbidities were common, particularly hypertension (49.7%), dyslipidaemia (40.1%) and gout (15.9%). | 29268719 |
| Increased insulin level, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia and hepatic overproduction of glucose and lipids. | 29269047 |
| Prostate Cancer Outcomes Study | Deregulated Nutrient Sensing | Vitamin D deficiency may contribute to the development of insulin resistance, visceral fat and low level of adiponectin which are common feature in PCOS women. | 29271278 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Recently, we demonstrated that plasma aldosterone contributed to insulin resistance in chronic kidney disease. | 29271574 |
| Cardiovascular system | Deregulated Nutrient Sensing | In conclusion, in hemodialysis patients, aldosterone levels and insulin resistance are closely interrelated and the constellation of the two is related to severe cardiovascular tissue damages. | 29271574 |
| Dyslipidemias, Bergamot | Deregulated Nutrient Sensing | Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial. | 29273027 |
| Dyslipidemias, Bergamot, Obesity | Deregulated Nutrient Sensing | Recent experiments suggest that Citrus bergamia extracts could benefit people with dyslipidemia and obesity but this needs to be further validated. | 29273027 |
| Dyslipidemias | Deregulated Nutrient Sensing | 12-week supplementation of CitriCholess could benefit lipid metabolism and weight management in old adults with dyslipidemia. | 29273027 |
| TG gene, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas. | 29273469 |
| Obesity, Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Predominantly male (80%, mean age 65.5years), cardiovascular risk factors were common (hypertension 65%, dyslipidemia 65%, obesity 25%, diabetes mellitus 28.5%, and smokers 67%). | 29276176 |
| Tumor necrosis | Deregulated Nutrient Sensing | Together, these findings suggest that BMI is associated with blood DNA methylation at a large number of CpGs across the genome, several of which are located in or near genes involved in ATP-binding cassette transportation, tumour necrosis factor signalling, insulin resistance and lipid metabolism. | 29278407 |
| Weight Gain, Hyperbilirubinemia, Dyslipidemias | Deregulated Nutrient Sensing | Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia. | 29279144 |
| Thyroid dysfunction, Dyslipidemias, Retinal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Thyroid dysfunction was more prevalent in females, with presence of dyslipidemia, retinopathy, poor glycemic state (HbA1c >=7) and longer duration of diabetes as significant contributing factors associated. | 29279270 |
| Communicable Diseases | Deregulated Nutrient Sensing | Sirtuin 1-Chromatin-Binding Dynamics Points to a Common Mechanism Regulating Inflammatory Targets in SIV Infection and in the Aging Brain. | 29280055 |
| Obesity | Deregulated Nutrient Sensing | However, in humans, the role of resistin in obesity and insulin resistance has not yet been demonstrated. | 29280648 |
| Obesity | Deregulated Nutrient Sensing | Our results do not support a relationship among resistin levels, obesity and insulin resistance in humans. | 29280648 |
| Hypertension, CTCAE, Dyslipidemias, Prehypertension | Deregulated Nutrient Sensing | Dependent variables: hypertension, pre-hypertension, overweight/obesity, impaired glucose, insulin resistance and dyslipidemia. | 29280649 |
| Hypertriglyceridemia, Dyslipidemias | Deregulated Nutrient Sensing | The lowest rate of dyslipidemia (hypertriglyceridemia or low high-density lipoprotein cholesterol) was observed in acute bipolar mania. | 29280686 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most common self-reported NCD was hypertension (17.%), followed by diabetes (16.3%) and dyslipidaemia (15.6%). | 29284464 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | The most prevalent risk factors were hypertension (78.8%), dyslipidemia (36.3%), and diabetes (31.9%). | 29284569 |
| Impaired cognition | Deregulated Nutrient Sensing | The findings in this present study highlight that hispidulin offers neuroprotection against sevoflurane-induced cognitive dysfunction, which is mediated by autophagy induction through activating AMPK signaling. | 29287193 |
| Pain Distress Question, Dyslipidemias, Hypertension, CTCAE | Deregulated Nutrient Sensing | The most common comorbidities were dyslipidaemia (40.3%), hypertension (40.1%) and generalised pain (38.1%). | 29287992 |
| Prediabetes syndrome, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Although increase in insulin resistance and decrease in beta-cell function both contributed to the progression to type 2 diabetes from prediabetes, longitudinal change in insulin resistance was the predominant factor in Koreans. | 29289263 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | About 70% of patients reported comorbid hypertension or dyslipidemia. | 29289467 |
| Metabolic Diseases | Deregulated Nutrient Sensing | Postoperative insulin resistance represents a major component of postoperative metabolic disorder. | 29306619 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | Vitamin D receptor activation by paricalcitol and insulin resistance in CKD. | 29307660 |
| Chronic Kidney Diseases | Deregulated Nutrient Sensing | The nature of the link (causal vs non-causal) between low 1,25-OH vitamin D and insulin resistance (IR) in patients with chronic kidney disease (CKD) remains elusive. | 29307660 |
| Endothelial dysfunction | Deregulated Nutrient Sensing | They had higher insulin resistance and endothelial dysfunction. | 29313572 |
| Dyslipidemias, Coronary Artery Disease, Obesity, Diabetes Mellitus | Deregulated Nutrient Sensing | Male patients were younger (69+-11years vs. 75+-12years in females; p<0.001) but had higher obesity (8.0% vs 6.5%), dyslipidemia (33.2% vs 28.1%), smoking (12.9% vs 9.2%), coronary artery disease (29.4% vs 19.5%), or diabetes rates (35.8% vs 28.1%; each p<0.001). | 29329771 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pattern Of Dyslipidaemia And Its Association With Hypovitaminosis D In Type 2 Diabetes Mellitus. | 29330987 |
| Dyslipidemias | Deregulated Nutrient Sensing | The purpose of our study was to determine the pattern of dyslipidaemia and its association with low vitamin D levels in South Asian diabetics. | 29330987 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | We found that dyslipidaemia is highly prevalent in patients with type 2 diabetes mellitus in Pakistan. | 29330987 |
| Hyperglycemia, Dyslipidemias, Complications of Diabetes Mellitus | Deregulated Nutrient Sensing | In order to decrease the development of diabetic complications aggressive management of hyperglycaemia and dyslipidaemia is required. | 29330987 |
| Weight decreased | Deregulated Nutrient Sensing | Our data show that the rs10767664 variant of the BDNF gene modifies insulin resistance and insulin levels after weight loss with a hypocaloric diet enriched with MUFAs. | 29339649 |
| Dyslipidemias, Diabetes Mellitus, Hypertension, CTCAE, Obesity | Deregulated Nutrient Sensing | Age, gender, living area, employment status, obesity, hypertension, and dyslipidemia are the contributing factors to diabetes mellitus. | 29348378 |
| Non-alcoholic Fatty Liver Disease, Obesity | Deregulated Nutrient Sensing | One of the adipokines is resistin, the role of which in insulin resistance, obesity, and non-alcoholic fatty liver disease (NAFLD) needs to be determined. | 29363914 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Resistin probably plays a role in the pathogenesis of hepatic insulin resistance and aggravates pathologic changes in the liver of patients with NAFLD. | 29363914 |
| Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Resistin expression was more intense in patients with type 2 diabetes mellitus and dyslipidaemia and less intense in the control group. | 29363914 |
| Obesity | Deregulated Nutrient Sensing | Predictors of Insulin Resistance in Children versus Adolescents with Obesity. | 29375912 |
| Metabolic Diseases | Deregulated Nutrient Sensing | This study indicates that cadmium burden alters glycemic control in adolescents and suggests that oxidative stress plays a key role in cadmium-induced insulin resistance, increasing the risk of developing metabolic disorders. | 29379585 |
| Steatohepatitis, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Hypertension, CTCAE | Deregulated Nutrient Sensing | LSG improved dyslipidemia in 67.8% of patients, a significant remission of hepatic steatosis 47% and 37.7% systemic arterial hypertension; type 2 diabetes remission was complete. | 29412386 |
| Carcinogenic Chlorinated Hydrocarbon, Hepatitis C | Deregulated Nutrient Sensing | This study aims to estimate the prevalence of insulin resistance (IR) among chronic hepatitis C (CHC) patients and their related laboratory and demographic data. | 29412389 |
| Dyslipidemias, Kidney Diseases | Deregulated Nutrient Sensing | The association between the increase in pulse pressure and renal function in chronic kidney disease patients with dyslipidemia. | 29441846 |
| Dyslipidemias, Chronic Kidney Diseases | Deregulated Nutrient Sensing | Therefore, we examined the association of increased PP on renal function in patients with CKD and dyslipidemia. | 29441846 |
| Dyslipidemias, Hypertension, CTCAE, Musculoskeletal Diseases, Diabetes Mellitus | Deregulated Nutrient Sensing | Hypertension (48.6%), dyslipidaemia (33.1%), musculoskeletal disorders (21.0%) and diabetes mellitus (16.1%) were the most frequent comorbidities. | 29441984 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes. | 29445750 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes. | 29445750 |
| Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Monocyte surface CD163 expression levels were more significantly associated with insulin resistance than sCD163 in patients with type 2 diabetes, suggesting a novel pathophysiological role of CD163. | 29445750 |
| Hypertension, CTCAE, Heart failure, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Risk factors were 60 (75.9%), smoking, 47 (59.5%) hypertension, 25 (31.6%) diabetes, 22 (27.8%) dyslipidaemia and 16 (20.3%) heart failure. | 29453473 |
| Dyslipidemias, Obesity | Deregulated Nutrient Sensing | Further, by multiple logistic regression analysis we found that only dyslipidemia (p = 0,001), obesity (p = 0,007), testosterone < 300 ng/dl (p < 0,0001) and ED (p < 0,0001) were independent predictors of future events. | 29473384 |
| Narcolepsy, Glucose Intolerance (disease), Headache, Traumatic injury, Peripheral Neuropathy | Deregulated Nutrient Sensing | At the end of the prolonged observation period of 9.9 years (SD 7.27 years), there was increased association of narcolepsy with peripheral neuropathy (11.21, 1.16-108.11), non-migrainous headache (6.00, 1.73-20.83), glucose intolerance (2.39, 1.05-5.45), and automobile-related trauma (2.43, 1.08-5.45). | 29482805 |
| Vascular Diseases, Dyslipidemias, Decline in functional status, ETV3 wt Allele | Deregulated Nutrient Sensing | Risk factors including MetS, old age, sex, wide pulse pressure, increased hemoglobin A1c, dyslipidemia and decline renal function were associated with micro- and macrovascular disease. | 29661347 |
| Hypertension, CTCAE, Dyslipidemias | Deregulated Nutrient Sensing | Hypertension, dyslipidemia, and smoking, in this order of magnitude, were the most prevalent risk factors. | 29701366 |
| ARCN1 gene, Dyslipidemias, Renal Insufficiency, Hypertension, CTCAE, Diabetes Mellitus, Non-Insulin-Dependent, Aortic valve disorder | Deregulated Nutrient Sensing | The preoperative comorbidities were hypertension (83.9%), aortic valve disease (54.8%), dyslipidaemia (48.4%), renal impairment (9.7%), type 2 diabetes mellitus (9.7%) and COPD (3.2%). | 29701390 |
| Peripheral Vascular Diseases, CAV1 gene, Dyslipidemias | Deregulated Nutrient Sensing | Although not reaching statistical significance, CAV patients also had more dyslipidemia (60% vs. 50%), history of smoking (52% vs. 44%) and peripheral vascular disease (45% vs. 29%). | 29701389 |
| ARCN1 gene, Dyslipidemias, Renal Insufficiency, Hypertension, CTCAE, Aortic valve disorder | Deregulated Nutrient Sensing | The preoperative comorbidities were hypertension (64.5%), dyslipidaemia (45.2%), aortic valve disease (35.4%), renal impairment (9.7%) and COPD (3.2%). | 29701394 |
| Dyslipidemias | Deregulated Nutrient Sensing | They also had low incidence of coronary risk factors (especially dyslipidemia, p=0.04). | 29716697 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias, Diabetes Mellitus, Non-Insulin-Dependent, Obesity | Deregulated Nutrient Sensing | Metabolic risk factors associated with non-alcoholic fatty liver disease (NAFLD) include Type 2 diabetes mellitus (T2DM), obesity and dyslipidaemia. | 29778128 |
| Hypertension, CTCAE, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Cardio-vascular risk factors (%): hypertension (60), Mellitus diabetes (47), dyslipidemia (29) and smoking (26). | 29878290 |
| Non-alcoholic Fatty Liver Disease, Dyslipidemias | Deregulated Nutrient Sensing | Studies suggest that the main pathophysiologic and pathogenetic processes of formation of NAFLD (insulin resistance and dyslipidemia) significantly more pronounced in younger patients. | 29889391 |
| Demographics Domain, Diabetes Mellitus, Non-Insulin-Dependent | Deregulated Nutrient Sensing | Pioglitazone is an extremely useful agent in the treatment of type 2 diabetes mellitus (DM) through its actions on alleviating insulin resistance. | 29900709 |
| Non-alcoholic Fatty Liver Disease, Prediabetes syndrome | Deregulated Nutrient Sensing | Elevated levels of serum uric acid and insulin resistance are associated with nonalcoholic fatty liver disease among prediabetic subjects. | 30234279 |
| Non-alcoholic Fatty Liver Disease | Deregulated Nutrient Sensing | Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of insulin resistance and serum uric acid (SUA) levels seemed to be elevated during this disorder. | 30234279 |
| Non-alcoholic Fatty Liver Disease, Prediabetes syndrome | Deregulated Nutrient Sensing | Increased levels of serum uric acid are significantly associated with NAFLD and this association seemed to be mediated by insulin resistance among prediabetic subjects. | 30234279 |
| Obesity, Abdominal, Cardiovascular Diseases, Hyperglycemia, Dyslipidemias, Diabetes Mellitus | Deregulated Nutrient Sensing | Length of service can determine cases numbers of cardiovascular disorders, diabetes mellitus manifestations, more frequent combination of hyperglycemia and/or hyper-, dyslipidemia with abdominal obesity. | 30351723 |
| Diastolic dysfunction, Dyslipidemias | Deregulated Nutrient Sensing | There was no significant association between diastolic dysfunction and dyslipidaemia, BMI, tobacco smoking, alcohol consumption, HbA1c and gender. | 30353895 |
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